title: Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study.
abstract: The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders.
authors.affiliation: Australian Neuro-muscular Research Institute and Centre for Neuromuscular and Neurological disorders, University of Western Australia, Queen Elizabeth II Medical Centre, Perth, WA, Australia.
authors.forename: Arada
authors.initials: A
authors.lastname: Rojana-Udomsart
authors.forename: Christine
authors.initials: C
authors.lastname: Bundell
authors.forename: Ian
authors.initials: I
authors.lastname: James
authors.forename: Alison
authors.initials: A
authors.lastname: Castley
authors.forename: Patricia
authors.initials: P
authors.lastname: Martinez
authors.forename: Frank
authors.initials: F
authors.lastname: Christiansen
authors.forename: Peter
authors.initials: P
authors.lastname: Hollingsworth
authors.forename: Frank
authors.initials: F
authors.lastname: Mastaglia
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D016133:Polymerase Chain Reaction
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D059811:HLA-DRB1 Chains