title: CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?
abstract: CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.
authors.affiliation: Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics / Q000378:metabolism; D020964:Embryo Loss / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D059565:G2 Phase Cell Cycle Checkpoints; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints; D008297:Male; D038901:X-Linked Intellectual Disability / Q000201:enzymology / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism
chemical_list: C493957:Cdkn1a protein, mouse; C524851:Cul4B protein, mouse; D044842:Cullin Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21