title: Protein translocation as a tool: The current rapamycin story.
abstract: In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science.
authors.affiliation: Cell Biology and Biophysics Unit, EMBL Heidelberg, 69117 Heidelberg, Germany.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Putyrski
authors.forename: Carsten
authors.initials: C
authors.lastname: Schultz
mesh_terms: D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D055503:Protein Multimerization / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D020123:Sirolimus / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D007166:Immunosuppressive Agents; D011506:Proteins; D020123:Sirolimus