title: Formation of ultrafine deferasirox particles via rapid expansion of supercritical solution (RESS process) using Taguchi approach.
abstract: The poor water solubility of many drugs is a challenge in pharmaceutical research. Recently, there have been great interests in finding environmentally friendly methods producing fine particles of pharmaceutical products for applications in pharmaceutical engineering. A promising method to improve the bioavailability of pharmaceutical agents is the rapid expansion of supercritical solutions. Deferasirox (DFS), a tridentate chelator, requires two molecules for iron (III) coordination. The bioavailability (the percentage of the drug absorbed compared to its initial dosage) is limited by this insolubility. The effect of four different RESS parameters including, extraction temperature (308-318K), extraction pressure (140-200 bar), effective nozzle diameter (500-1200 μm), with and without cosolvents were investigated on the size and morphology of the precipitated particles of deferasirox based on Taguchi design. The results show great reduction in the size of the precipitated particles of deferasirox (50 nm-5 μm) via RESS process compared with the original particles of deferasirox (5-500 μm).
authors.affiliation: School of Chemical and Petroleum Engineering, Shiraz University, Shiraz, Iran. Asghari.iman@gmail.com
authors.forename: Iman
authors.initials: I
authors.lastname: Asghari
authors.forename: Feridun
authors.initials: F
authors.lastname: Esmaeilzadeh
mesh_terms: D001565:Benzoates / Q000008:administration & dosage* / Q000737:chemistry; D000077588:Deferasirox; D004339:Drug Compounding / Q000379:methods; D007502:Iron Chelating Agents / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles; D010316:Particle Size; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D014230:Triazoles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D012997:Solvents; D014230:Triazoles; D000077588:Deferasirox