title: Cancer cell metabolism: there is no ROS for the weary.
abstract: Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and cancer cell death, suggesting that PFKFB4 could be therapeutically targeted.
authors.affiliation: Abramson Cancer Center, Abramson Family Cancer Research Institute, Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19072, USA. dangvchi@upenn.edu
authors.forename: Chi V
authors.initials: CV
authors.lastname: Dang
mesh_terms: D006801:Humans; D008297:Male; D055432:Metabolomics; D025481:Phosphofructokinase-2 / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: C506672:PFKFB4 protein, human; D025481:Phosphofructokinase-2