title: Synthesis of N-substituted acridinediones and polyhydroquinoline derivatives in refluxing water.
abstract: Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in reﬂuxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing  good to excellent yields.
authors.affiliation: School of Materials and Chemical Engineering, Anhui University of Architecture, Hefei 230601, China. xiajj@aiai.edu.cn
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xia
authors.forename: Ke-Hua
authors.initials: KH
authors.lastname: Zhang
mesh_terms: D000085:Acetates / Q000737:chemistry; D000090:Acetoacetates / Q000737:chemistry; D000166:Acridines / Q000138:chemical synthesis*; D000447:Aldehydes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
chemical_list: D000085:Acetates; D000090:Acetoacetates; D000166:Acridines; D000447:Aldehydes; D000814:Aniline Compounds; D003512:Cyclohexanones; D011804:Quinolines; D014867:Water; C024840:ethyl acetoacetate; C018824:ammonium acetate; C021313:methylaniline