title: Reaction product analysis of aconitine in dilute ethanol using ESI-Q-ToF-MS.
abstract: The study was done to identify the reaction products of aconitine in dilute ethanol using electrospray ionization-triple quad time-of-flight mass spectrometry (ESI-Q-TOF-MS). Five hydrolysates were detected, their pseudo-molecules are 632, 604, 586, 570, 500, they are 8-ethyoxyl-14-benzoylaconitine, benzoylaconine, pyraconitine, 8-acetyl-14-ethyoxylaconitine, aconine, respectively. Among them, 8-ethyoxyl-14-benzoylaconitine and 8-acetyl-14-ethyoxylaconitine were identified firstly as reaction products of aconitine in dilute ethanol, and can thus be used as indicators in quality control of medicinal Aconitum preparations used in Traditional Chinese Medicine.
authors.affiliation: Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Tan
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Qiao
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives / Q000032:analysis*; D000276:Adjuvants, Immunologic / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol; D007202:Indicators and Reagents; D008516:Medicine, Chinese Traditional / Q000592:standards; D011786:Quality Control; D012015:Reference Standards; D012996:Solutions; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D012996:Solutions; D012997:Solvents; D000431:Ethanol; D000157:Aconitine