title: Quinoline-3-carboxamide derivatives as potential cholesteryl ester transfer protein inhibitors.
abstract: A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.
authors.affiliation: Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Li
authors.forename: Xu-Qiong
authors.initials: XQ
authors.lastname: Xiong
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Shi
authors.forename: Zhi-Heng
authors.initials: ZH
authors.lastname: Yang
authors.forename: Chao
authors.initials: C
authors.lastname: Yu
authors.forename: Pei-Wei
authors.initials: PW
authors.lastname: Fan
authors.forename: Mao-Sheng
authors.initials: MS
authors.lastname: Cheng
authors.forename: Jing-Kang
authors.initials: JK
authors.lastname: Shen
mesh_terms: D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis*; D012996:Solutions
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D011804:Quinolines; D012996:Solutions; C541322:quinoline-3-carboxamide