title: The placental component in early-onset and late-onset preeclampsia in relation to fetal growth restriction.
abstract: OBJECTIVE
  To identify pathological placental differences between early-onset and late-onset preeclampsia, in relation to fetal growth restriction (FGR).
  
  
  METHODS
  Placentas from patients with preeclampsia were analyzed for lesions of maternal vascular supply consistent with maternal underperfusion and lesions of fetal vascular supply consistent with fetal thrombo-occlusive disease. Findings were compared between patients who gave birth before 34 weeks (early-onset preeclampsia) and after 34 weeks (late-onset preeclampsia).
  
  
  RESULTS
  Compared with the late-onset group (n = 93), the early-onset group (n = 37) had higher rates of FGR (62.2% vs 25.8%, P < 0.001) and lesions of maternal vascular supply (95% vs 60%, P < 0.001). Within the early-onset group, cases with FGR (n = 23) had more lesions of fetal vascular supply (47.8% vs 7%, P = 0.01), with similar high rates of lesions of maternal vascular supply (91% vs 100%) compared with those without FGR. Within the late-onset preeclampsia group, cases with FGR (n = 24) had higher rates of maternal vascular supply lesions (88% vs 51%, P = 0.003) than those without FGR, but similar rates of fetal vascular supply lesions (25% vs 16%, P = 0.32).
  
  
  CONCLUSIONS
  The placental fetal vascular supply lesions in combination with maternal vascular lesions are more dominant in early-onset preeclampsia with FGR as compared with early-onset preeclampsia without FGR.
authors.affiliation: Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. michalkovo@gmail.com
authors.forename: Michal
authors.initials: M
authors.lastname: Kovo
authors.forename: Letizia
authors.initials: L
authors.lastname: Schreiber
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
authors.forename: Eran
authors.initials: E
authors.lastname: Gold
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Jacob
authors.initials: J
authors.lastname: Bar
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology* / Q000503:physiopathology; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D010920:Placenta / Q000473:pathology* / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000473:pathology* / Q000503:physiopathology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D013997:Time Factors