title: Effect of probiotics on the treatment of children with atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic dermatitis.
  
  
  OBJECTIVE
  In this double-blind, randomized, placebo-controlled study, a combination of Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, and Lactobacillus salivarius strains were evaluated in the treatment of atopic dermatitis in pediatric patients.
  
  
  METHODS
  Forty pediatric patients (23 males and 17 females) aged 1~13 years were enrolled. One eligible individual who was approached declined to participate. The probiotic group was administered a probiotic complex containing B. bifidum, L. acidophilus, L. casei, and L. salivarius for 8 weeks. The placebo group, on the other hand, was administered skim milk powder and dextrose. All of the parameters including serum cytokines, eosinophil cationic protein), SCORing Atopic Dermatitis (SCORAD) index, and total serum immunoglobulin E (IgE) were measured in both the probiotic group and the placebo group at the end of 8 weeks.
  
  
  RESULTS
  Probiotic intervention in pediatric atopic dermatitis patients effectively reduced the SCORAD index and serum cytokines interleukin (IL)-5, IL-6, interferon (IFN)-γ, and total serum IgE levels, but did not reduce levels of serum cytokines IL-2, IL-4, IL-10, ECP, or tumor necrosis factor-α (TNF-α) compared to the placebo group.
  
  
  CONCLUSIONS
  Our study found probiotics to be effective in reducing atopic dermatitis patients' SCORAD index, serum IL-5, IL-6, IFN-γ, and total serum IgE levels but not effective in reducing serum IL-2, IL-4, IL-10, ECP, or TNF-α levels.
authors.affiliation: Department of Dermatology, Harran University Faculty of Medicine, Sanliurfa, Turkey. yavuzyesilova@gmail.com
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yeşilova
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Çalka
authors.forename: Necmettin
authors.initials: N
authors.lastname: Akdeniz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Berktaş