title: Predictors of the short-term effect of isoleucine-proline-proline/valine-proline-proline lactotripeptides from casein on office and ambulatory blood pressure in subjects with pharmacologically untreated high-normal blood pressure or first-degree hypertension.
abstract: Our aim was to evaluate the predictors of Isoleucine-Proline-Proline/Valine-Proline-Proline (IPP-VPP) lactotripeptides (LTPs) antihypertensive effect in the context of a short-term large double-blind randomized clinical trial involving 164 pharmacologically untreated subjects in primary prevention for cardiovascular disease. When compared with the baseline, office systolic blood pressure (SBP) (-3.42 mm Hg, P < .001) and diastolic blood pressure (DBP) (-2.35 mm Hg, P < .001) significantly decreased, in the LTP-treated patients only. No significant change in predictors during the study of ambulatory blood pressure measurement (ABPM) parameters was observed. A short-term supplementation with LTPs significantly improves the office SBP and DBP, especially in male subjects. The main predictor of LTP antihypertensive effect was the baseline BP.
authors.affiliation: Hypertension Research Center, Department of Internal Medicine, Aging and Kidney Disease, University of Bologna, Bologna, Italy. afgcicero@cardionet.it
authors.forename: A F G
authors.initials: AF
authors.lastname: Cicero
authors.forename: M
authors.initials: M
authors.lastname: Rosticci
authors.forename: A
authors.initials: A
authors.lastname: Ferroni
authors.forename: S
authors.initials: S
authors.lastname: Bacchelli
authors.forename: M
authors.initials: M
authors.lastname: Veronesi
authors.forename: E
authors.initials: E
authors.lastname: Strocchi
authors.forename: C
authors.initials: C
authors.lastname: Borghi
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002364:Caseins / Q000737:chemistry; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009819:Office Visits; D009842:Oligopeptides / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002364:Caseins; D009842:Oligopeptides; C489032:isoleucyl-prolyl-proline; C489031:valyl-prolyl-proline