title: Oxidative stress as a cofactor in spinocerebellar ataxia type 2.
abstract: Spinocerebellar ataxia type 2 (SCA2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. Currently, Cuba has the highest reported global rate for this disease. The aim of this review article is to summarize and discuss the current knowledge about evidence of oxidative stress during SCA2. Recent reports have suggested that ataxin 2 and other related factors contribute to the redox imbalance in this disease. It is important to recognize and clarify the molecular mechanisms associated with the redox imbalance to consider ataxias innovative approaches to counteract oxidative stress-induced tissue damage, through alternative therapeutic or nutritional intervention in SCA2 and related diseases.
authors.affiliation: Biopharmaceutical and Chemical Group (LABIOFAM), Research and Development Department, Avenida Independencia Km 16 1/2, Boyeros, Havana, Cuba.
authors.forename: Mariela
authors.initials: M
authors.lastname: Guevara-García
authors.forename: Lizette
authors.initials: L
authors.lastname: Gil-del Valle
authors.forename: Luis
authors.initials: L
authors.lastname: Velásquez-Pérez
authors.forename: Julio César
authors.initials: JC
authors.lastname: García-Rodríguez
mesh_terms: D000328:Adult; D000067528:Ataxins; D003462:Cuba / Q000453:epidemiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018384:Oxidative Stress; D020754:Spinocerebellar Ataxias / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*
chemical_list: D000067528:Ataxins; D009419:Nerve Tissue Proteins