title: Portal vein thrombosis in a patient with Turner's syndrome: a case report.
abstract: This work aimed at reporting a case of Turner's syndrome with portal vein thrombosis and elevated levels of factor VIII and von Willebrand factor. A 14-year-old Libyan girl was admitted for evaluation of infantilism and pallor; meanwhile, she was found to be of short stature, with webbing of the neck. Chromosomal studies showed monosomy pattern Turner's syndrome (45XO). Abdominal ultrasound displayed a hugely enlarged spleen. Computed tomography (CT) imaging of the abdomen revealed portal vein thrombosis and dilated venous collaterals in porta hepatis. Thrombophilia screening demonstrated elevated levels of factor VIII (207 IU dl(-1)) and von Willebrand factor (450 IU dl(-1)). It was concluded that this was a case report on the unusual finding of portal vein thrombosis in a patient with Turner's syndrome in whom high levels of factor VIII and von Willebrand factor were found. Detailed molecular epidemiological study is recommended to clarify this finding and its underlying factors.
authors.affiliation: Pediatric Department, Zagazig University, Egypt. soadshedeed@gmail.com
authors.forename: Soad A
authors.initials: SA
authors.lastname: Shedeed
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D014424:Turner Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D014463:Ultrasonography; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014841:von Willebrand Factor; D005169:Factor VIII