title: Angiogenic stimuli and endoglin absence induces brain arteriovenous malformations: are local endoglin deletion and angiogenesis the 'second hit' that is necessary for arteriovenous malformations formation in HHT-1?
authors.affiliation: Renal and Cardiovascular Physiopathology Unit, Reina Sofía Institute for Renal Research, Department of Physiology and Pharmacology, University of Salamanca, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. jmlnovoa@usal.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Lopez-Novoa
mesh_terms: D030201:Activin Receptors, Type I / Q000235:genetics*; D030301:Activin Receptors, Type II; D000818:Animals; D000071063:Endoglin; D017353:Gene Deletion; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D054220:Malformations of Cortical Development / Q000235:genetics*
chemical_list: D000071063:Endoglin; C502004:Eng protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; C498931:Acvrl1 protein, mouse