title: E23K polymorphism of the KCNJ11 gene in Korean children with type 1 diabetes.
abstract: BACKGROUND
  This study was undertaken to evaluate the association of the E23K polymorphism of KCNJ11 and type 1 diabetes in a Korean population.
  
  
  METHODS
  Clinical variables from 70 Korean children with type 1 diabetes were analyzed. Patients' DNA was screened for the E23 locus in the KCNJ11 gene. Each genotype frequency and clinical characteristics according to the genotypes were compared between the patient and control groups.
  
  
  RESULTS
  The genotype frequencies of the KCNJ11 E23 polymorphic locus in the patient group were 30.0% for EE, 44.3% for EK, and 25.7% for KK. We detected no differences in genotype frequencies between the patient and control groups. Additionally, in the patient group, no difference was detected in the clinical phenotypes among the three genotypes.
  
  
  CONCLUSIONS
  Although a rather small sample size constituted a limitation of this study, the association of the E23K polymorphism with type 1 diabetes was not statistically significant in the Korean population evaluated.
authors.affiliation: Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Ko
authors.forename: Seung
authors.initials: S
authors.lastname: Yang
authors.forename: Se Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Hyo Sung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jin Soon
authors.initials: JS
authors.lastname: Hwang
authors.forename: Il Tae
authors.initials: IT
authors.lastname: Hwang
mesh_terms: D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics*; D012189:Retrospective Studies; D000099161:Kcnj11 Channel
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000099161:Kcnj11 Channel