title: Polymorphisms and haplotypes in candidate genes related to angiogenesis and endothelial dysfunction in preeclampsia.
abstract: Valenzuela and colleagues have recently reviewed some polymorphisms in important candidate genes involved in different pathogenic mechanisms related to preeclampsia (PE) and concluded that various studies in different populations have identified maternal polymorphisms associated with PE. However, we would like to contribute to some studies regarding candidate genes related to angiogenesis and endothelial dysfunction in PE performed in the Brazilian population. Specifically, genotypes and haplotypes formed by polymorphisms of VEGF, eNOS and MMP-9, along with an example of the interaction among these genes in the prediction of PE. Our suggestions may provide additional information with clinical relevance to PE susceptibility.
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil.
authors.forename: Marcelo Rizzatti
authors.initials: MR
authors.lastname: Luizon
authors.forename: Ana Carolina Taveiros
authors.initials: AC
authors.lastname: Palei
authors.forename: Valeria Cristina
authors.initials: VC
authors.lastname: Sandrim
mesh_terms: D005260:Female; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D005819:Genetic Markers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D052250:Nitric Oxide Synthase Type III; D020780:Matrix Metalloproteinase 9