title: Development of Guillain-Barré syndrome in a patient with multiple sclerosis during treatment with glatiramer acetate.
abstract: Some observations suggest that in some patients with multiple sclerosis demyelination may affect the central and peripheral nervous systems at the same time. The influence of immunomodulatory therapy on peripheral nervous system damage in these patients is still unknown. We present a 43-year-old male patient with multiple sclerosis diagnosed at the age of 35 in whom flaccid tetraparesis with dysaesthesia preceded by paraesthesias of four limbs occurred one year after starting glatiramer acetate. The course of peripheral nervous system disease and results of cerebrospinal fluid examination and electromyography confirmed Guillain-Barré syndrome. Interfering in the immunological system, glatiramer acetate may have contributed to the development of the symptoms of Guillain-Barré syndrome in our patient. The final improvement of the patient's condition may have resulted not only from the applied treatment and the natural course of the disease, but may have also been associated with the discontinuation of glatiramer acetate.
authors.affiliation: Oddział Neurologii SPSK nr 7, Śląski Uniwersytet Medyczny, ul. Ziołowa 45-47, 40-635 Katowice.
authors.forename: Ewa
authors.initials: E
authors.lastname: Motta
authors.forename: Anna
authors.initials: A
authors.lastname: Gołba
authors.forename: Maciej
authors.initials: M
authors.lastname: Huć
authors.forename: Zofia
authors.initials: Z
authors.lastname: Kazibutowska
mesh_terms: D000328:Adult; D000068717:Glatiramer Acetate; D020275:Guillain-Barre Syndrome / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy*; D010455:Peptides / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate