title: Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries.
abstract: OBJECTIVE
  This study evaluated the antibacterial activity of the SiF solution with the addition of antibacterial agents on a Streptococcus mutans biofilm.
  
  
  METHODS
  Various antibacterial SiF solutions were prepared by adding chlorhexidine, cetylpyridinium chloride, isopropyl methylphenol, or epigallocatechin gallate. Hydroxyapatite pellets treated with several SiF solutions were immersed in BHI inoculated with S. mutans standardized suspension. The number of S. mutans cells adhered to each pellet was evaluated.
  
  
  RESULTS
  SiF with the addition of CPC was the most effective for reducing the adherence of bacteria and inhibiting the formation ofbiofilm, showing the same level as AgF, In contrast, the addition of other antibacterial agents to SiF reduced the original antibacterial activity of SiF solution.
authors.affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Shibata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Suge
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kimura
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuo
mesh_terms: D000134:Acid Etching, Dental; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D058491:Bacterial Load / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D002327:Cariostatic Agents / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D002594:Cetylpyridinium / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D003804:Dentin / Q000187:drug effects*; D017886:Durapatite / Q000737:chemistry; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010636:Phenols / Q000494:pharmacology; D010756:Phosphoric Acids / Q000737:chemistry; D012824:Silicic Acid / Q000494:pharmacology*; D018030:Silver Compounds / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects; D017155:Wettability
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D010636:Phenols; D010756:Phosphoric Acids; D018030:Silver Compounds; D012824:Silicic Acid; C004832:hexafluorosilicate; C105022:silver fluoride; D002392:Catechin; D017886:Durapatite; C045651:epigallocatechin gallate; D002594:Cetylpyridinium; C030242:phosphoric acid; D005459:Fluorides; D002710:Chlorhexidine