title: [Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
abstract: Mutant gene wallhaarig (wa) was acting as a modifier of the mutant gene waved alopecia (wal), substantially increasing hair loss rate in mice, as was previously shown in our laboratory. The current paper is devoted to a study of mutant gene angora- Y(Fgf5(go-Y)), which had extended anagen stage of the first and second generations hair growth cycles in triple heterozygotes (Fgf5(go-Y)/Fgf5(go-Y) we/we wal/wal). First generation guard hair in triple homozygotes had their anagen stage 4 days longer than the same stage in double homozygotes (+/+ we/we wal/wal). Hair loss started at a catagen stage in double homozygotes, while it started in triple homozygotes at the end of the same stage or even in a telogen. Such mutant gene interaction in hair follicle morphogenesis led to a partial recovery of a body hair coat in triple homozygotes.
authors.forename: A P
authors.initials: AP
authors.lastname: Nesterova
authors.forename: I I
authors.initials: II
authors.lastname: Nizamutdinov
authors.forename: B V
authors.initials: BV
authors.lastname: Koniukhov
mesh_terms: D000505:Alopecia / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D051521:Fibroblast Growth Factor 5 / Q000235:genetics*; D006197:Hair / Q000254:growth & development*; D018859:Hair Follicle / Q000502:physiology; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation
chemical_list: C496450:Fgf5 protein, mouse; D051521:Fibroblast Growth Factor 5