title: Functional neuroimaging in Parkinson's disease.
abstract: The use of functional imaging in neurodegenerative diseases has increased in recent years, with applications in research into the underlying pathophysiology, aiding in diagnosis, or evaluating new treatments. In Parkinson's disease (PD), these imaging methods have expanded our understanding of the disease beyond dopaminergic deficits. Moreover, functional imaging methods have described alterations in functional networks relating not only to the motor symptoms, but also to many nonmotor features of PD, such as cognitive dysfunction. From a clinical viewpoint, functional imaging methods can assist in monitoring disease progression, such as in the context of clinical trials, and holds the potential to aid in early diagnosis of PD and differentiation from other parkinsonian disorders.
authors.affiliation: The Feinstein Institute for Medical Research, Manhasset, New York, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Niethammer
authors.forename: Andrew
authors.initials: A
authors.lastname: Feigin
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects; D001928:Brain Diseases, Metabolic / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology; D018450:Disease Progression; D004298:Dopamine / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D019788:Fluorodeoxyglucose F18; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D016631:Lewy Bodies / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D018377:Neurotransmitter Agents / Q000502:physiology; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000503:physiopathology; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000978:Antiparkinson Agents; D018377:Neurotransmitter Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007980:Levodopa; D004298:Dopamine