title: Restoring cell polarity: an HSC fountain of youth.
abstract: Until recently, aging was viewed as a fixed and irreversible process. However, in this issue of Cell Stem Cell, Florian et al. (2012) reveal a link between increased activity of the RhoGTPase Cdc42, hematopoietic stem cell polarity, and aging that can be regulated by pharmacological inhibition of Cdc42.
authors.affiliation: Department of Hematology/Oncology, University Hospital Bonn, 53127 Bonn, Germany.
authors.forename: Carmen
authors.initials: C
authors.lastname: Carrillo-García
authors.forename: Viktor
authors.initials: V
authors.lastname: Janzen