title: Significant peri-operative reduction in plasma osteopontin levels after coronary artery by-pass grafting.
abstract: OBJECTIVE
  Osteopontin (OPN) is a multifunctional protein associated with vascular injury and has been linked to atherosclerosis and inflammation. We sought to investigate whether OPN changes in relation to coronary artery by-pass grafting (CABG) surgery.
  
  
  METHODS
  We studied 50 consecutive patients (63 ± 10 years old, 6 women and 44 men) undergoing elective CABG. Plasma OPN levels were determined by an enzyme-linked immunosorbent assay at baseline and in 24 and 72 h, post-operatively. Cardiac enzymes - creatine kinase, the MB isoenzyme of creatine kinase, troponin-I- and C-reactive protein (CRP) were also determined at all three time points.
  
  
  RESULTS
  OPN levels 72 h post-op decreased significantly compared to pre-op and 24h post-op levels (p<0.001) whereas there was no difference between the pre-op and first post-op values (p=0.57). The relative change in OPN levels between pre-op and 72 h post-op correlated negatively with absolute troponin-I levels at 72 h post-op (-0.51, p=0.005). OPN levels 72 h post-op correlated significantly with CRP at baseline (r=0.73, p=0.002).
  
  
  CONCLUSIONS
  OPN plasma concentrations decreased after CABG surgery in the early post-operative period. The significance of this observation needs further investigation.
authors.affiliation: 2nd Division of Interventional Cardiology, Onassis Cardiac Surgery Center, Athens, Greece. esbarouni@yahoo.gr
authors.forename: Eftihia
authors.initials: E
authors.lastname: Sbarouni
authors.forename: Panagiota
authors.initials: P
authors.lastname: Georgiadou
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mihas
authors.forename: Antigoni
authors.initials: A
authors.lastname: Chaidaroglou
authors.forename: Demitris
authors.initials: D
authors.lastname: Degiannis
authors.forename: Vassilis
authors.initials: V
authors.lastname: Voudris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D011184:Postoperative Period; D019210:Troponin I / Q000097:blood
chemical_list: C506895:SPP1 protein, human; D019210:Troponin I; D053495:Osteopontin; D002097:C-Reactive Protein; D052279:Creatine Kinase, MB Form