title: Comparison of pathways associated with hepatitis B- and C-infected hepatocellular carcinoma using pathway-based class discrimination method.
abstract: Molecular signatures causing hepatocellular carcinoma (HCC) from chronic infection of hepatitis B virus (HBV) or hepatitis C virus (HCV) are not clearly known. Using microarray datasets composed of HCV-positive HCC or HBV-positive HCC, pathways that could discriminate tumor tissue from adjacent non-tumor liver tissue were selected by implementing nearest shrunken centroid algorithm. Cancer-related signaling pathways and lipid metabolism-related pathways were predominantly enriched in HCV-positive HCC, whereas functionally diverse pathways including immune-related pathways, cell cycle pathways, and RNA metabolism pathways were mainly enriched in HBV-positive HCC. In addition to differentially involved pathways, signaling pathways such as TGF-β, MAPK, and p53 pathways were commonly significant in both HCCs, suggesting the presence of common hepatocarcinogenesis process. The pathway clustering also verified segregation of pathways into the functional subgroups in both HCCs. This study indicates the functional distinction and similarity on the pathways implicated in the development of HCV- and/or HBV-positive HCC.
authors.affiliation: Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Kwang Hoon
authors.initials: KH
authors.lastname: Song
authors.forename: Imhoi
authors.initials: I
authors.lastname: Koo
authors.forename: Kee-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
authors.forename: Bu-Yeo
authors.initials: BY
authors.lastname: Kim
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000821:virology; D002453:Cell Cycle; D004247:DNA / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D016174:Hepacivirus / Q000302:isolation & purification / Q000472:pathogenicity; D006509:Hepatitis B / Q000235:genetics* / Q000473:pathology; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000472:pathogenicity; D006526:Hepatitis C / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D046228:Microarray Analysis; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D017422:Sequence Analysis, DNA; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta; D004247:DNA; D020928:Mitogen-Activated Protein Kinases