title: An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds.
abstract: In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.
authors.affiliation: Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001.
authors.forename: Y S
authors.initials: YS
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Venkatesh
authors.forename: U S
authors.initials: US
authors.lastname: Misra
authors.forename: B
authors.initials: B
authors.lastname: Suresh
authors.forename: M A
authors.initials: MA
authors.lastname: Azam
authors.forename: M
authors.initials: M
authors.lastname: Sethuraman