title: New metabolites from the marine-derived fungus Aspergillus fumigatus.
abstract: A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4 631 associated with the soft coral Sinularia sp. Their structures were determined by HR-MS and 1D and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation. afiyat@piboc.dvo.ru
authors.forename: Shamil Sh
authors.initials: SSh
authors.lastname: Afiyatullov
authors.forename: Olesya I
authors.initials: OI
authors.lastname: Zhuravleva
authors.forename: Alexandr S
authors.initials: AS
authors.lastname: Antonov
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Michail V
authors.initials: MV
authors.lastname: Pivkin
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Menchinskaya
authors.forename: Dmitry L
authors.initials: DL
authors.lastname: Aminin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000970:Antineoplastic Agents / Q000302:isolation & purification; D001232:Aspergillus fumigatus / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011799:Quinazolines; D014315:Triterpenes; C572484:fumiquinazoline K