title: Immunological aspects in viral hepatitis B and C infection.
abstract: Worldwide, viral hepatitis chronic infections are a serious health problem and a very interesting topic for both clinicians and researchers. Viral hepatitis has a variety of clinical forms: mild, inactive or severe and with a slow evolution, whose architectural structure of the hepatic tissue evolves towards cirrhosis or hepatocellular carcinoma. Sometimes, the virally induced hepatic injury evolves spectacularly and rapidly leads to exitus. The factors that generate this evolution pattern depend on the immune response of the host and equally on the viral survival and immune surveillance avoidance strategies. This paper aims to resume new discoveries in the field of immunology of the B and C viral hepatitis infection, from the perspective of the complex interactions between virus and host.
authors.affiliation: Immunology Department, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor" Cluj-Napoca, Romania. irena.manea@gmail.com
authors.forename: Irena
authors.initials: I
authors.lastname: Manea
authors.forename: Cristian Nicolae
authors.initials: CN
authors.lastname: Manea
authors.forename: Nicolae
authors.initials: N
authors.lastname: Miron
authors.forename: Victor
authors.initials: V
authors.lastname: Cristea
mesh_terms: D015415:Biomarkers; D015815:Cell Adhesion Molecules / Q000032:analysis; D018450:Disease Progression; D006509:Hepatitis B / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000032:analysis
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D020782:Matrix Metalloproteinases