title: Development of a micro-dosing system for fine powder using a vibrating capillary. Part 2. The implementation of a process analytical technology tool in a closed-loop dosing system.
abstract: In an earlier study, a micro-dosing system for fine powder using a vibrating capillary which can precisely dose various lactose powders, was introduced. In scaling up to a multi-track dosing system, it was suggested that additional track cut-offs can improve the dosing performance by reducing the overruns. A non-contact in-line control unit within a closed-loop system is required to achieve this goal. Due to its very fast response time (a few milliseconds) a capacitive sensor was integrated together with multi track cut-offs into a closed-loop dosing system. With this improvement a standard dosing deviation as low as 0.1mg was achieved. The results suggest its application in precise filling of fine pharmaceutical powders.
authors.affiliation: Harro Hoefliger Verpackungsmaschinen GmbH, Helmholtzstraße 4, 71573 Allmersbach im Tal, Germany. xiaolong.chen@hoefliger.de
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Chen
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Seyfang
authors.forename: Hartwig
authors.initials: H
authors.lastname: Steckel
mesh_terms: D004339:Drug Compounding / Q000379:methods; D004867:Equipment Design; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D011208:Powders; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors
chemical_list: D005079:Excipients; D011208:Powders; D007785:Lactose