title: Bordetella holmesii meningitis in an asplenic patient with systemic lupus erythematosus.
abstract: Bordetella holmesii is a slow-growing, Gram-negative, non-oxidizing bacillus with colonies that produce a brown soluble pigment and was originally described by Weyant et al. (1995) as CDC nonoxidizer group 2 (NO-2). It has recently been shown that B. holmesii may be isolated from nasopharyngeal specimens of up to 20% of patients with pertussis-like symptoms. However, invasive B. holmesii has rarely been reported and in the vast majority of cases the patients were immune deficient, mostly as a result of splenectomy or functional asplenia. Clinical presentations have included endocarditis, pneumonia, cellulitis, suppurative arthritis, pyelonephritis and septicaemia but no previous reports have documented meningitis secondary to this organism. Here we report what we believe to be the first clinical description of an adult with B. holmesii meningitis and bacteraemia with a brief review of published cases.
authors.affiliation: Hadassah-Hebrew University Medical Center, Mount-Scopus Campus, Jerusalem 91240, Israel.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Livovsky
authors.affiliation: Hadassah-Hebrew University Medical Center, Mount-Scopus Campus, Jerusalem 91240, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Leibowitz
authors.affiliation: Hadassah-Hebrew University Medical Center, Ein-Karem Campus, Jerusalem 91240, Israel.
authors.forename: Carlos
authors.initials: C
authors.lastname: Hidalgo-Grass
authors.affiliation: Hadassah-Hebrew University Medical Center, Ein-Karem Campus, Jerusalem 91240, Israel.
authors.forename: Violeta
authors.initials: V
authors.lastname: Temper
authors.affiliation: Hadassah-Hebrew University Medical Center, Mount-Scopus Campus, Jerusalem 91240, Israel.
authors.forename: Shaden
authors.initials: S
authors.lastname: Salameh
authors.affiliation: Hadassah-Hebrew University Medical Center, Mount-Scopus Campus, Jerusalem 91240, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Korem
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology; D001884:Bordetella / Q000302:isolation & purification*; D001885:Bordetella Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D013154:Spleen / Q000002:abnormalities*