title: Grounded: transcriptional pausing in naive mESCs.
abstract: Growing mouse pluripotent stem cells in defined media with signaling inhibitors establishes a naive ground state different from that of cells grown in serum. Recently in Cell, Marks et al. (2012) reported differences in the transcriptional and epigenomic landscapes of naive and serum-exposed mouse stem cells that improve our understanding of the pluripotent ground state.
authors.affiliation: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Guenther
authors.forename: Richard A
authors.initials: RA
authors.lastname: Young