title: mGlu3 receptor and astrocytes: partners in neuroprotection.
abstract: Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes. Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions. This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.
authors.affiliation: Instituto de Investigaciones Biomédicas (INBIOMED), School of Medicine, University of Buenos Aires, Paraguay 2155 Piso 10, CABA 1121 Buenos Aires, Argentina. ddurand@fmed.uba.ar
authors.forename: Daniela
authors.initials: D
authors.lastname: Durand
authors.forename: Lila
authors.initials: L
authors.lastname: Carniglia
authors.forename: Carla
authors.initials: C
authors.lastname: Caruso
authors.forename: Mercedes
authors.initials: M
authors.lastname: Lasaga
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008024:Ligands; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D008959:Models, Neurological; D058990:Molecular Targeted Therapy / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D018690:Excitatory Amino Acid Agonists; D008024:Ligands; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3