title: Epigenetic interplay of histone modifications and DNA methylation mediated by HDA6.
abstract: One of the most fundamental questions in the control of gene expression is how epigenetic patterns of DNA methylation and histone modifications are established. Our recent studies demonstrate that histone deacetylase HDA6 integrates DNA methylation and histone modifications in gene silencing by interacting with DNA methyltransferase MET1 and histone demethylase FLD, suggesting that regulatory crosstalk between histone modifications and DNA methylation could be mediated by the interaction of various epigenetic modification proteins.
authors.affiliation: Institute of Plant Biology, National Taiwan University, Taipei, Taiwan.
authors.forename: Xuncheng
authors.initials: X
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Luo
authors.forename: Keqiang
authors.initials: K
authors.lastname: Wu
mesh_terms: D019175:DNA Methylation / Q000235:genetics*; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000378:metabolism*; D056466:Histone Demethylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000235:genetics*
chemical_list: D006657:Histones; D056466:Histone Demethylases; D006655:Histone Deacetylases