title: Quantitative consensus of bioaccumulation models for integrated testing strategies.
abstract: A quantitative consensus model based on bioconcentration factor (BCF) predictions obtained from five quantitative structure-activity relationship models was developed for bioaccumulation assessment as an integrated testing approach for waiving. Three categories were considered: non-bioaccumulative, bioaccumulative and very bioaccumulative. Five in silico BCF models were selected and included into a quantitative consensus model by means of the continuous formulation of Bayes' theorem. The discrete likelihoods commonly used in the qualitative Bayesian model were substituted by probability density functions to reduce the loss of information that occurred when continuous BCF values were distributed across the three bioaccumulation categories. Results showed that the continuous Bayesian model yielded the best classification predictions compared not only to the discrete Bayesian model, but also to the individual BCF models. The proposed quantitative consensus model proved to be a suitable approach for integrated testing strategies for continuous endpoints of environmental interest.
authors.affiliation: Departament d'Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalunya, Spain. alberto.fernandez@urv.cat
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández
authors.forename: Anna
authors.initials: A
authors.lastname: Lombardo
authors.forename: Robert
authors.initials: R
authors.lastname: Rallo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Roncaglioni
authors.forename: Francesc
authors.initials: F
authors.lastname: Giralt
authors.forename: Emilio
authors.initials: E
authors.lastname: Benfenati
mesh_terms: D001499:Bayes Theorem; D003198:Computer Simulation; D032921:Consensus; D004777:Environment; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000378:metabolism*; D008956:Models, Chemical; D011336:Probability; D021281:Quantitative Structure-Activity Relationship
chemical_list: D004785:Environmental Pollutants