title: TNF related apoptosis-inducing ligand and its receptors in ocular tumors.
abstract: Most of the ocular tumors have poor prognosis, and they remain a difficult problem in the area of ophthalmology. With the rapid development of molecular biology and immunologic techniques and the deep research on ocular tumor related genes, it becomes possible to diagnose and treat malignant tumors from the molecular level. The tumor necrosis factor related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) super family, is a promising candidate, either alone or in combination with established cancer therapies, since it can initiate apoptosis through the activation of their death receptors. The ability of TRAIL to selectively induce apoptosis of transformed, virus-infected or tumor cells but not normal cells promotes the development of TRAIL-based cancer therapy. Here, we will review TRAIL and its receptors' structure, function, mechanism of action and application in ocular tumors therapy.
authors.affiliation: Department of Oncology, the First hospital Affiliated to School of Medicine of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Ning
authors.forename: Lei
authors.initials: L
authors.lastname: Hou
authors.forename: Min
authors.initials: M
authors.lastname: Meng
authors.forename: Bo-Rong
authors.initials: BR
authors.lastname: Pan
authors.forename: Xin-Han
authors.initials: XH
authors.lastname: Zhao