title: Confocal scanning laser ophthalmoscope in the retromode imaging modality in exudative age-related macular degeneration.
abstract: OBJECTIVE
  To evaluate the ability of confocal scanning laser ophthalmoscope (cSLO) in the retromode imaging modality in detecting retinal changes secondary to exudative age-related macular degeneration (AMD).
  
  
  METHODS
  Seventeen eyes of 13 consecutive patients affected by CNV secondary to AMD were evaluated with optical coherence tomography (OCT) to detect neuroretinal detachment (NRD), pigment epithelial detachment (PED), cystoid macular edema (CME), and epiretinal membranes (ERM). All eyes were examined with a cSLO equipped with infrared retromode (RM) imaging modality. Infrared and fundus autofluorescence images were also obtained (IR and FAF). The intermethod agreement between OCT and cSLO was evaluated considering single cSLO imaging modality separately (IR, FAF, and RM), and all imaging modalities together.
  
  
  RESULTS
  Eight eyes (47 %) had NRD at OCT; intermethod agreement was poor for any single cSLO imaging modality considered separately (k: 0.14, 0.01, and 0.29 for cSLO IR, FAF, and RM, respectively). Four eyes had PED at OCT (24 %); intermethod agreement was mild for cSLO RM, poor for IR and FAF (k: 0.51, 0.16, and 0.00, respectively). CME was present in eight eyes (47 %); intermethod agreement was excellent for cSLO RM, poor for IR and FAF (k: 0.88, 0.38, and 0.26, respectively). ERM was present in three eyes (18 %); intermethod agreement was mild for cSLO IR, poor for FAF, and excellent for RM (k: 0.59, 0.00, and 0.76, respectively).
  
  
  CONCLUSIONS
  cSLO RM imaging is a useful and reproducible technique in detecting retinal features associated with CNV, particularly CME.
authors.affiliation: Department of Ophthalmology, University of Padova, via Giustiniani 2, 35128 Padova, Italy. elisabetta.pilotto@unipd.it
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pilotto
authors.forename: Patrik
authors.initials: P
authors.lastname: Sportiello
authors.forename: Ernesto
authors.initials: E
authors.lastname: Alemany-Rubio
authors.forename: Stela
authors.initials: S
authors.lastname: Vujosevic
authors.forename: Sara
authors.initials: S
authors.lastname: Segalina
authors.forename: Iva
authors.initials: I
authors.lastname: Fregona
authors.forename: Edoardo
authors.initials: E
authors.lastname: Midena
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents; D019773:Epiretinal Membrane / Q000175:diagnosis; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008269:Macular Edema / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000175:diagnosis; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D057135:Wet Macular Degeneration / Q000175:diagnosis*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green