title: Interactome: Smart hematophagous triatomine salivary gland molecules counteract human hemostasis during meal acquisition.
abstract: Human populations are constantly plagued by hematophagous insects' bites, in particular the triatomine insects that are vectors of the Trypanosoma cruzi agent in Chagas disease. The pharmacologically-active molecules present in the salivary glands of hematophagous insects are injected into the human skin to initiate acquisition of blood meals. Sets of vasodilators, anti-platelet aggregators, anti-coagulants, immunogenic polypeptides, anesthetics, odorants, antibiotics, and detoxifying molecules have been disclosed with the aid of proteomics and recombinant cDNA techniques. These molecules can provide insights about the insect-pathogen-host interactions essential for understanding the physiopathology of the insect bite. The data and information presented in this review aim for the development of new drugs to prevent insect bites and the insect-transmitted endemic of Chagas disease.
authors.affiliation: Chagas Disease Multidisciplinary Research Laboratory, Faculty of Medicine of the University of Brasilia, 70.910.900, Brasília Federal District, Brazil. cnunes@unb.br
authors.forename: Carla Nunes
authors.initials: CN
authors.lastname: de Araújo
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Bussacos
authors.forename: Alessandro O
authors.initials: AO
authors.lastname: Sousa
authors.forename: Mariana M
authors.initials: MM
authors.lastname: Hecht
authors.forename: Antonio R L
authors.initials: AR
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D001081:Apyrase / Q000494:pharmacology; D014355:Chagas Disease / Q000635:transmission; D006487:Hemostasis / Q000187:drug effects*; D054884:Host-Pathogen Interactions; D006801:Humans; D007299:Insect Bites and Stings / Q000503:physiopathology*; D012469:Salivary Glands / Q000737:chemistry; D012471:Salivary Proteins and Peptides / Q000737:chemistry / Q000494:pharmacology*; D014224:Triatoma / Q000235:genetics; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D012471:Salivary Proteins and Peptides; D014665:Vasodilator Agents; D001081:Apyrase