title: Downregulation of hepatoma-derived growth factor suppresses the malignant             phenotype of U87 human glioma cells.
abstract: Hepatoma-derived growth factor (HDGF) has been shown to correlate with increased malignancy of different types of tumors and could be an independent prognostic index for human cancers. We previously found that HDGF is overexpressed in glioma tissues and that its expression level may correlate with the clinical pathological grade. In the present study, we investigated the effects of HDGF downregulation on the biological behaviors of U87 glioma cells. Our results showed that HDGF knockdown significantly inhibited the malignant phenotype of U87 cells, including the colony formation, migration and invasion in vitro, as well as tumorigenesis in vivo. Our data also suggest that hepatocyte growth factor/scatter factor (HGF/SF) may contribute to the HDGF-associated aggressive behavior of glioma cells.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing, PR China. aixiazh@gmail.com
authors.forename: Aixia
authors.initials: A
authors.lastname: Zhang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Long
authors.forename: Ze
authors.initials: Z
authors.lastname: Guo
authors.forename: Zhenying
authors.initials: Z
authors.lastname: Guo
authors.forename: Brian B
authors.initials: BB
authors.lastname: Cao
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D015536:Down-Regulation; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010641:Phenotype; D034622:RNA Interference; D047368:Tumor Burden
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C051610:hepatoma-derived growth factor