title: Investigation of antioxidant and anti-inflammatory activity of leaves of Dalbergia paniculata (Roxb).
abstract: OBJECTIVE
  To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculata (D. paniculata) in Carrageenan induced inflammation in rats.
  
  
  METHODS
  In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DPPH radical scavenging activity. Three doses 200 mg/kg, 400 mg/kg and 800 mg/kg of D. paniculata were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h.
  
  
  RESULTS
  The methanolic leaf extract of D. paniculata produced dose dependent inhibition of Superoxide radical, Hydroxyl radical and DPPH radicals. In Carrageenan induced inflammation model, all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema (47.83%) at 3h compared to control group.
  
  
  CONCLUSIONS
  In the present study we found that methanolic leaf extract of D. paniculata showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.
authors.affiliation: Pharmacognosy and Phytochemistry, A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India.
authors.forename: Rao B
authors.initials: RB
authors.lastname: Ganga
authors.forename: Kiran P
authors.initials: KP
authors.lastname: Madhu
authors.forename: Raju A D
authors.initials: RA
authors.lastname: Vijaya
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D035782:Dalbergia; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D017665:Hydroxyl Radical; D002351:Carrageenan