title: Use of autologous platelet rich fibrin in urethracutaneous fistula repair: preliminary report.
abstract: Urethrocutaneous fistula (UCF) is one of the most common complications occurring after hypospadias repair. Despite the surgical advancement in hypospadias, multiple failed fistula closures are commonly referred to paediatric urologists. Although several techniques have been described to interpose a waterproof layer between urethral and skin closures, occurrence of urethrocutaneous fistula cannot be eliminated completely. In addition to several local tissue grafts, autologous and homologous fibrin sealants are used to prevent UCF. Platelet rich fibrin (PRF) is known as an autologous source of growth factors obtained from the sera of the patient. PRF supports collagen synthesis and tissue repair and accelerates wound healing. We aimed to present our initial experience about the use of autologous PRF in a 3-year-old boy with a UCF after hypospadias repair.
authors.affiliation: Department of Pediatric Surgery, School of Medicine, Kırıkkale University, 71100 Kırıkkale, Turkey. soyer.tutku@gmail.com
authors.forename: Tutku
authors.initials: T
authors.lastname: Soyer
authors.forename: Murat
authors.initials: M
authors.lastname: Çakmak
authors.forename: Mustafa K
authors.initials: MK
authors.lastname: Aslan
authors.forename: Mine F
authors.initials: MF
authors.lastname: Şenyücel
authors.forename: Üçler
authors.initials: Ü
authors.lastname: Kisa
mesh_terms: D002675:Child, Preschool; D017577:Cutaneous Fistula / Q000150:complications / Q000628:therapy*; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D014014:Tissue Adhesives / Q000494:pharmacology; D014522:Urethral Diseases / Q000150:complications / Q000628:therapy*; D014548:Urinary Fistula / Q000150:complications / Q000628:therapy*; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives