title: Phaeophytin analogues from Ligularia knorringiana.
abstract: A new phaeophytin, ligulariaphytin A, together with five known phaeophytins, were isolated from the aerial parts of Ligularia knorringiana. The structure of ligulariaphytin A was elucidated as 13¹-hydroxy-13¹,13²-peroxyphaeophorbide A ethyl ester, and the five known compounds were identified as 13²-hydroxyphaeophorbide A ethyl ester, 17³-ethoxyphaeophorbide A, phaeophytin B, phaeophytin A, and phaeophorbide B ethyl ester, respectively, based on spectroscopic analysis and by comparison of their spectral data with those reported previously in the literature. All compounds were evaluated for their in vitro cytotoxic activities against cultured Hela cell, and were found to show only very weak cytotoxicity.
authors.affiliation: Key Laboratory of Xin Jiang Phytomedicine Resources, School of Pharmacy, Shihezi University, Shihezi 832002, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Lina
authors.initials: L
authors.lastname: Li
authors.forename: Qiusheng
authors.initials: Q
authors.lastname: Zheng
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kuroda
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010674:Pheophytins / Q000138:chemical synthesis* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010674:Pheophytins; D010936:Plant Extracts; C574342:ligulariaphytin A