title: Association of the resistin gene promoter region polymorphism with Kawasaki disease in Chinese children.
abstract: OBJECTIVE
  The -420 C > G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children.
  
  
  METHODS
  We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method.
  
  
  RESULTS
  There was no significant difference in RETN (-420 C > G) genotypes between KD and control groups. However, the frequency of the G allele was higher in iKD patients than in cKD children due to a significantly increased frequency of the GG genotypes. Serum levels of resistin were significantly higher in KD patients than in controls regardless of the presence of coronary artery lesions (CALs).
  
  
  CONCLUSIONS
  The present findings suggest that while resistin may play a role in the pathogenesis of KD, there is no apparent association between CAL and the RETN (-420 C > G) gene polymorphism in KD children. However, the diagnosis of iKD is challenging but can be supported by the presence of the G allele and the GG genotypes.
authors.affiliation: Department of Cardiovascular Medicine, Children's Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders and Key Laboratory of Pediatrics in Chongqing, China.
authors.forename: Ruixi
authors.initials: R
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: He
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Qijian
authors.initials: Q
authors.lastname: Yi
mesh_terms: D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002681:China; D004452:Echocardiography / Q000379:methods; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D007223:Infant; D007249:Inflammation; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000208:ethnology* / Q000235:genetics*; D010455:Peptides / Q000737:chemistry; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D052243:Resistin / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics*
chemical_list: D010455:Peptides; C499624:RETN protein, human; D052243:Resistin