title: Interhemispheric effective and functional cortical connectivity signatures of spina bifida are consistent with callosal anomaly.
abstract: The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the θ and α bands.
authors.affiliation: Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Sheida
authors.initials: S
authors.lastname: Malekpour
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Li
authors.forename: Bing Leung Patrick
authors.initials: BL
authors.lastname: Cheung
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Castillo
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Papanicolaou
authors.forename: Larry A
authors.initials: LA
authors.lastname: Kramer
authors.forename: Jack M
authors.initials: JM
authors.lastname: Fletcher
authors.forename: Barry D
authors.initials: BD
authors.lastname: Van Veen
mesh_terms: D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology; D007223:Infant; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology*; D016135:Spinal Dysraphism / Q000473:pathology* / Q000503:physiopathology