title: [Effect of transfer of fragment of chromosome 13, containing gene i16st on parameters of mouse temperature homeostasis].
abstract: Mechanisms of maintenance of temperature homeostasis in warm and under effect of cold were studied in mice of AKR strain and of its coherent strain AKR.CBA-D13Mit76 with the changed gene i16st encoding the gp 130 receptor, via which IL-6 performs its action. Under thermoneutral conditions and under action of cold, there were recorded temperature parameters, total oxygen consumption, carbon dioxide release, respiratory coefficient, and electrical muscle activity. Animals of the studied strains demonstrated different reactions to equal cold effect. At cooling, all mice of the AKR strain entered the state of hypothermia by decreasing metabolism. Mice of the AKR.CBA-D13Mit76 line showed 2 different types of reaction: 39 % of the animals of this strain reacted like mice of the AKR strain, but the majority (61 %) resisted actively to the cold action, which was manifested as a marked increase of metabolism. Taking into account the gene penetrance, this can indicate effect of the gene i16st on choice of the active ("regulated") or passive ("dependent") way of the organism reacting to temperature actions.
authors.forename: I P
authors.initials: IP
authors.lastname: Voronova
authors.forename: G M
authors.initials: GM
authors.lastname: Khramova
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: T V
authors.initials: TV
authors.lastname: Kozyreva
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D050822:Cytokine Receptor gp130 / Q000235:genetics*; D018014:Gene Transfer Techniques; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D010101:Oxygen Consumption / Q000235:genetics; D019683:Penetrance; D022722:Thermogenesis / Q000235:genetics*
chemical_list: C494200:Il6st protein, mouse; D050822:Cytokine Receptor gp130