title: Ultrasonographic description of brain cortex and cingulate sulcus development in Mexican neonates and infants with congenital hypothyroidism.
abstract: BACKGROUND
  Ultrasonography of cortical and cingulum maturity patterns, were studied in newborns and infants with congenital hypothyroidism (CH).
  
  
  METHODS
  Transversal study of 29 newborns and infants with CH, detected by neonatal screening and confirmed with thyroid function test, thyroid ultrasonography, and thyroid scintigraphy. During the first 2 months of life, transfontanelar brain ultrasonography was performed. Brain cortex maturity was assessed by normality referents provided by Slagle and Timor methods.
  
  
  RESULTS
  Cortical immaturity signs were observed in 69% of infants (20 patients with Slage's method brain cortex development delay (Pearson's p=0.05). Logistic nominal analysis for normality prediction demonstrated a correlation between brain cortex development and age, bone age, treatment duration, and type of CH. The most sensitive detecting technique was sagittal sight by Slagle's method.
  
  
  CONCLUSIONS
  Brain cortex delayed development is frequent in children with CH. Bone age, postnatal age at treatment start, and time since treatment start, correlates with neurological development, but not athyreosis or sublingual nodule.
authors.affiliation: Follow-up Neurodevelopment Laboratory, Instituto Nacional de Pediatría and Universidad Autónoma Metropolitana Xochimilco, México City, México. galvara@prodigy.net.mx
authors.forename: Gerardo A
authors.initials: GA
authors.lastname: Alvarado-Ruiz
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez-Pérez
authors.forename: Eugenio
authors.initials: E
authors.lastname: Morales
authors.forename: Mario
authors.initials: M
authors.lastname: Mandujano
authors.forename: Rosa Ivone
authors.initials: RI
authors.lastname: Martínez-Vázquez
authors.forename: María de la Luz
authors.initials: Mde L
authors.lastname: Ruiz-Reyes
authors.forename: Raúl
authors.initials: R
authors.lastname: Calzada-León
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002657:Child Development; D003409:Congenital Hypothyroidism / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008800:Mexico; D011446:Prospective Studies; D014463:Ultrasonography