title: Age-related aneuploidy through cohesion exhaustion.
abstract: The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.
authors.affiliation: Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fiedlerstrasse 42, 01326 Dresden, Germany. rolf.jessberger@tu-dresden.de
authors.forename: Rolf
authors.initials: R
authors.lastname: Jessberger
mesh_terms: D000367:Age Factors; D000375:Aging; D000782:Aneuploidy; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism / Q000502:physiology; D020090:Chromosome Segregation; D006801:Humans; D008540:Meiosis; D009865:Oocytes / Q000502:physiology; D009866:Oogenesis / Q000235:genetics; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins