title: The impact of genomics on pediatric research and medicine.
abstract: In this review, we discuss some of the most recent developments in genomics research and their relevance to the field of pediatrics. In particular, we examine 3 major approaches that are being used to identify genetic correlates of disease: genome-wide association studies, copy number variation studies, and next-generation sequencing. In the past few years, these approaches have yielded major insights into the causes and pathophysiology of a wide range of diseases but are also constrained by certain limitations. This review provides an overview of the genomic landscape in complex pediatric disorders and sets the stage for translating new discoveries into clinical practice, the future of genomic medicine.
authors.affiliation: Center for Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Research Center, Suite 1216E, Philadelphia, PA 19104, USA. connollyj1@chop.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Connolly
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
mesh_terms: D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D008511:Medicine / Q000379:methods / Q000639:trends; D010372:Pediatrics / Q000379:methods* / Q000639:trends