title: Decreased survival among lung cancer patients with co-morbid tuberculosis and diabetes.
abstract: BACKGROUND
  Comorbid conditions influence the survival of cancer patients. This study evaluated the influence of comorbidity on survival among lung cancer patients.
  
  
  METHODS
  The authors evaluated the medical records of 1111 lung cancer patients of a medical center in Taiwan. Days of survival were calculated for each patient and mortality hazard ratios were estimated for associations with demographic status, comorbidity and cancer stage at diagnosis.
  
  
  RESULTS
  On average, the survival time was slightly longer among women than among men (838±689 vs. 749±654 days, p = 0.050). Survival days increased with age (from 580±526 [≤ 50 years] to 803±693 [≥ 71 years] days, p = 0.020) and decreased with stage (from 1224±656 [stage I] to 489±536 [stage IV] days, p < 0.001). Younger patients were more likely to be diagnosed with lung cancer at a late stage. Compared with lung cancer patients without tuberculosis, those with tuberculosis had a significantly shorter average survival duration (584 vs. 791 days, p = 0.002) and a higher mortality hazard ratio (1.30, 95% CI: 1.03 - 1.65). A similar trend was observed in lung cancer patients with diabetes.
  
  
  CONCLUSIONS
  Lung cancer patients with comorbid tuberculosis or diabetes are at an elevated risk of mortality. These patients deserve greater attention while undergoing cancer treatment.
authors.affiliation: Department of Health Services Administration, China Medical University, Taichung 40402, Taiwan.
authors.forename: Shwn-Huey
authors.initials: SH
authors.lastname: Shieh
authors.forename: Janice C
authors.initials: JC
authors.lastname: Probst
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.forename: Wen-Chen
authors.initials: WC
authors.lastname: Tsai
authors.forename: Ya-Shin
authors.initials: YS
authors.lastname: Li
authors.forename: Chih-Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging