title: Levetiracetam-associated loss of libido and anhedonia.
abstract: The relationship between the older antiepileptic drugs (AEDs) and sexual dysfunction has long been known and it is likely to be related to sexual hormonal changes. Instead, rare reports on sexual disorders related to new AEDs suggest the possibility of complex and poorly understood mechanisms, mainly involving central nervous system neurotransmitters such as glutamate, serotonin, and dopamine. Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake.
authors.affiliation: IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy. salbro77@tiscali.it
authors.forename: Rocco S
authors.initials: RS
authors.lastname: Calabrò
authors.forename: Domenico
authors.initials: D
authors.lastname: Italiano
authors.forename: David
authors.initials: D
authors.lastname: Militi
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000328:Adult; D059445:Anhedonia / Q000187:drug effects*; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000150:complications / Q000188:drug therapy; D017029:Epilepsy, Complex Partial / Q000150:complications / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D000077213:Lamotrigine; D000077287:Levetiracetam; D007989:Libido / Q000187:drug effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014227:Triazines / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D014227:Triazines; D000077287:Levetiracetam; D014635:Valproic Acid; D000077213:Lamotrigine; D010889:Piracetam