title: Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients.
abstract: The complex of serum amyloid A(SAA) and low-density lipoprotein (LDL), SAA-LDL, is considered a new and unique marker of oxidatively-modified LDL particles, which is associated with atherosclerotic conditions. This study investigated the influence of atorvastatin treatment on circulating SAA-LDL levels among asymptomatic hypercholesterolemic patients. A total of 26 patients (mean age 63 years) received 10 mg/daily atorvastatin during a 12-week treatment period. The levels of LDL cholesterol and SAA-LDL, but not high-sensitivity C-reactive protein and SAA, were significantly reduced after the treatment. Stepwise adjusted regression analyses revealed that changes of SAA-LDL were significantly and positively correlated with those of SAA, while absolute changes were small, which warrants further investigation. The results suggest that atorvastatin may beneficially reduce SAA-LDL, and SAA-LDL may be a sensitive measure for monitoring the efficacy and antioxidant functions of atorvastatin.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi 320-0498, Japan. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamada
authors.forename: Michiaki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gugliucci
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D000069059:Atorvastatin; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011758:Pyrroles / Q000627:therapeutic use*; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D006538:Heptanoic Acids; D008077:Lipoproteins, LDL; D011758:Pyrroles; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein; D000069059:Atorvastatin