title: [Misdiagnosis of 3 cases lymphoma due to misjudgement of immunohistochemistry].
abstract: OBJECTIVE
  To recognize the importance of analyzing the result of immunohistochemical staining correctly.
  
  
  METHODS
  Review of the three misdiagnosed cases lymphoma and exploring the causes of misdiagnosis through reviewing their clinics, histopathology and immunohistochemistry.
  
  
  RESULTS
  Case 1 of lymphocyte rich classical Hodgkin's lymphoma (LRCHL) was misdiagnosed as follicular lymphoma (FL) initially, the RS cells were overlooked morphologically and wrongly determined BCL-2 and CD20-positive cells as tumor cells immunohistochemically; also once misdiagnosed as nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) because the CD20-negative RS misjudged cells as the positives. Case 2 of AML tumor cells expressed TdT, CD7 and CD43 unspecifically, which misdiagnosed as T-cell lymphoblastic lymphoma (T-LBL). Case 3 of type B1 thymoma was misdiagnosed as T-LBL, because CK wasn't expressed satisfactorily resulting in neglecting neoplastic epithelial cells, and lymphocytes in the background were TdT and CD99-positive.
  
  
  CONCLUSIONS
  The diagnosis of lymphoma should be based on morphology, immunohistochemistry, clinics, and genetics. Moreover, the correct judgment of immunohistochemical staining is essential to make right diagnosis.
authors.affiliation: Department of Pathology, Bengbu Medical College Affiliated the First Hospital, Anhui, China.
authors.forename: Cong-you
authors.initials: CY
authors.lastname: Gu
authors.forename: Xiang-dong
authors.initials: XD
authors.lastname: Qu
authors.forename: Yue-hui
authors.initials: YH
authors.lastname: Lin
authors.forename: Jiao-sheng
authors.initials: JS
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Zi-fen
authors.initials: ZF
authors.lastname: Gao
mesh_terms: D000328:Adult; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged