title: Analysis of attitudes toward the source of progenitor cells in tissue-engineered products for use in burns compared with other disease states.
abstract: The first trials using progenitor cells to improve burn wound healing are beginning. However, there remains a paucity of data on patients' opinions of the source of stem cells. In this study, 279 patients attending plastic surgery/burns outpatient and medical outpatient clinics were questioned to assess willingness to accept a tissue-engineered skin product derived from a variety of sources. Levels of acceptance for the use of progenitor cells derived from these sources for treatment across a range of disease states (burns, Parkinson's disease, diabetes, and for cosmetic use) were also assessed. Overall, 80% of those questioned would accept a tissue-engineered product. Autologous cells were the preferred choice of cells (acute burns 94%, diabetes 95%, Parkinson's 93.9%). Allogeneic cells were still widely accepted (acute burns 67%, diabetes 66.7%, Parkinson's 69.2%). There was no difference observed between plastic surgical patients and medical patients in acceptance of cell therapy for burns, Parkinson's disease, or diabetes. There is good potential acceptance for the use of both autologous and allogeneic cells for the treatment of acute burns and burns' scarring as well as in diabetes and Parkinson's disease. Disease state does not appear to influence overall acceptability and choice of cells.
authors.affiliation: Department of Plastic Surgery, University College Cork, Cork, Ireland. j.clover@ucc.ie
authors.forename: Anthony J P
authors.initials: AJ
authors.lastname: Clover
authors.forename: Billy Lane
authors.initials: BL
authors.lastname: O'Neill
authors.forename: Arun H S
authors.initials: AH
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001294:Attitude to Health; D002056:Burns / Q000453:epidemiology / Q000523:psychology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000523:psychology / Q000601:surgery*; D010342:Patient Acceptance of Health Care / Q000523:psychology / Q000706:statistics & numerical data*; D016038:Skin Transplantation / Q000379:methods; D013234:Stem Cells; D013518:Surgery, Plastic / Q000941:ethics* / Q000523:psychology / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D023822:Tissue Engineering / Q000941:ethics* / Q000706:statistics & numerical data; D014182:Transplantation, Autologous / Q000941:ethics / Q000523:psychology; D014945:Wound Healing; D055815:Young Adult