title: Stereoselective synthesis of pentacyclic steroids functionalized at C-11.
abstract: We set out to describe an efficient and versatile method for preparing pentacyclic steroids diversely substituted at C-11 from cholic acid, via a stereoselective epoxidation and the epoxide opening as the key steps. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported.
authors.affiliation: Institut des Sciences Moléculaires de Marseille UMR 7313 CNRS and Université d'Aix Marseille, Faculté des Sciences et Techniques de Saint Jérôme, Avenue Escadrille Normandie Niémen, 13397 Marseille, Cedex 20, France. malika.ibrahim@univ-cezanne.fr
authors.forename: Malika
authors.initials: M
authors.lastname: Ibrahim-Ouali
authors.forename: Eugénie
authors.initials: E
authors.lastname: Romero
authors.forename: Khalil
authors.initials: K
authors.lastname: Hamze
mesh_terms: D000588:Amines / Q000737:chemistry; D019826:Cholic Acid / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
chemical_list: D000588:Amines; D004852:Epoxy Compounds; D007783:Lactones; D013256:Steroids; D013438:Sulfhydryl Compounds; D013450:Sulfones; D019826:Cholic Acid