title: Effects of anodized implants coated with Escherichia coli-derived rhBMP-2 in beagle dogs.
abstract: This study evaluated the effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) coated onto anodized implants to stimulate bone formation, osseointegration and vertical bone growth in a vertical bone defect model. Six young adult beagle dogs were used. After a 2-month bone healing period, anodized titanium implants (8mm in length) were placed 5.5mm into the mandibular alveolar ridge. Eighteen implants coated with ErhBMP-2 (BMP group) and another 18 uncoated implants (control group) were installed using a randomized split-mouth design. The implant stability quotient (ISQ) values were measured. Specimens were fabricated for histometric analysis to evaluate osseointegration and bone formation. The ISQ values at 8 weeks after implant placement were significantly higher in the BMP group than in the control group (p<0.05). Histological observations showed that the changes in bucco-lingual alveolar bone levels were higher in the BMP group than in the control group (p<0.05). The ErhBMP-2 coated anodized implants can stimulate bone formation and increase implant stability significantly on completely healed alveolar ridges in dogs. Further studies evaluating the effects of ErhBMP-2 on osseointegration in the bone-implant interface are warranted.
authors.affiliation: Department of Prosthodontics, College of Dentistry, Pusan National University, YangSan, Republic of Korea.
authors.forename: Jung-Bo
authors.initials: JB
authors.lastname: Huh
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Hyo-Eon
authors.initials: HE
authors.lastname: Kim
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Choi
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Jeong
authors.forename: Jeong-Yol
authors.initials: JY
authors.lastname: Lee
authors.forename: Sang-Wan
authors.initials: SW
authors.lastname: Shin
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage*; D015921:Dental Implants; D004285:Dogs; D004926:Escherichia coli / Q000235:genetics*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D015921:Dental Implants; D011994:Recombinant Proteins