title: Parameters of blood count and tumor markers in patients with borderline ovarian tumors: a retrospective analysis and relation to staging.
abstract: The aim of this paper was to evaluate the parameters of blood count and tumor markers in borderline ovarian tumors. We evaluated 21 patients who had confirmed histopathologic diagnosis of borderline ovarian tumor. We recorded age, parity, tumor type, stage of cancer, serum levels of tumor markers (CA-125, CA-15.3, CA-19.9, CEA, AFP), and the parameters of blood count, fasting glucose, disease-free survival and overall. The patients were divided into two groups, stage IA (n = 13) and stage IB-IIIC (n = 8). The unpaired t-test and Fisher's exact test were used, with P values of less than 0.05 being considered to indicate statistical significance. Levels of red blood cells, hematocrit, and hemoglobin were significantly higher in stage IA when compared with stage IB-IIIC (P < 0.05). The levels of tumor marker CEA had a tendency to be higher in the group stage IB-IIIC (0.08). Abnormal levels of CEA and CA-19.9 were found more frequently in stages IB-IIIC. Therefore, parameters of blood count, CEA, and CA-19.9 should be targeted for further research in identifying prognostic factors in borderline tumors.
authors.affiliation: Discipline of Gynecology and Obstetrics, Oncological Research Institute (IPON), Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil.
authors.forename: Rosekeila Simões
authors.initials: RS
authors.lastname: Nomelini
authors.forename: Taísa Morete
authors.initials: TM
authors.lastname: da Silva
authors.forename: Beatriz Martins
authors.initials: BM
authors.lastname: Tavares Murta
authors.forename: Eddie Fernando Candido
authors.initials: EF
authors.lastname: Murta