title: Endothelin receptor antagonist bosentan improves the dermal sclerosis in a patient with systemic sclerosis.
abstract: We report a case of systemic sclerosis with interstitial pneumonia and severe pulmonary hypertension treated with bosentan, an endothelin receptor antagonist. Within a short period of administration of the bosentan the skin sclerosis improved.
authors.affiliation: Department of Dermatology, Fukushima Medical University, Fukushima, Japan. anishibu@kanazawa-med.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishibu
authors.forename: Erika
authors.initials: E
authors.lastname: Sakai
authors.forename: Noritaka
authors.initials: N
authors.lastname: Oyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000077300:Bosentan; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D013449:Sulfonamides; D000077300:Bosentan; D008775:Methylprednisolone