title: Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives.
abstract: Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Ple A Moro 5, 00185 Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Secci
authors.forename: Bruna
authors.initials: B
authors.lastname: Bizzarri
authors.forename: Adriana
authors.initials: A
authors.lastname: Bolasco
authors.forename: Simone
authors.initials: S
authors.lastname: Carradori
authors.forename: Melissa
authors.initials: M
authors.lastname: D'Ascenzio
authors.forename: Daniela
authors.initials: D
authors.lastname: Rivanera
authors.forename: Emanuela
authors.initials: E
authors.lastname: Mari
authors.forename: Lucia
authors.initials: L
authors.lastname: Polletta
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zicari
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D056945:Hep G2 Cells; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006834:Hydrazines