title: Success treatment of post-irradiation morphoea with acitretin and narrowband UVB.
abstract: Post-irradiation morphoea is a rare but under-recognised complication of radiotherapy treatment for breast cancer. Management of this condition is difficult, and many cases are recalcitrant to therapy. A 43-year-old woman with breast cancer received radiotherapy following a mastectomy and partial axillary lymph node dissection, shortly after which she developed a hot, tender, erythematous and indurated plaque at the mastectomy site. Subsequently the skin became retracted, depressed and hyperpigmented. The clinical features, along with histological findings, were consistent with post-irradiation morphoea. Treatment with narrowband ultraviolet B and acitretin 10 mg daily was commenced 5 years following radiotherapy. After 2 months of therapy the patient reported significant improvement in tenderness and range of left arm movement. Objectively the plaque was less indurated and softer to palpation. We propose that this treatment regimen is an option in the management of post-irradiation morphoea.
authors.affiliation: Department of Dermatology, Flinders Medical Centre, Adelaide, South Australia, Australia. kmnewland@live.com.au
authors.forename: Kate
authors.initials: K
authors.lastname: Newland
authors.forename: Gillian
authors.initials: G
authors.lastname: Marshman
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D012594:Scleroderma, Localized / Q000209:etiology / Q000628:therapy*; D014467:Ultraviolet Therapy
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin