title: Application of resequencing microarrays in microbial detection and characterization.
abstract: Microarrays are powerful, highly parallel assays that are transforming microbiological diagnostics and research. The adaptation of microarray-based resequencing technology for microbial detection and characterization resulted in the development of a number assays that have unique advantages over other existing technologies. This technological platform seems to be especially useful for sensitive and high-resolution multiplexed diagnostics for clinical syndromes with similar symptoms, screening environmental samples for biothreat agents, as well as genotyping and whole-genome analysis of single pathogens.
authors.affiliation: Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, SW, Washington, DC 20375, USA. tomasz.leski@nrl.navy.mil
authors.forename: Tomasz A
authors.initials: TA
authors.lastname: Leski
authors.forename: Baochuan
authors.initials: B
authors.lastname: Lin
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Malanoski
authors.forename: David A
authors.initials: DA
authors.lastname: Stenger
mesh_terms: D001419:Bacteria / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D015374:Biosensing Techniques / Q000379:methods; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*; D008828:Microbiological Techniques / Q000379:methods*; D025202:Molecular Diagnostic Techniques / Q000379:methods; D017422:Sequence Analysis, DNA / Q000379:methods*