title: Isoniazid-induced recurrent pancreatitis.
abstract: BACKGROUND
  Drug induced pancreatitis are rare but potentially serious. Thus, drug withdrawal is warranted.
  
  
  METHODS
  A 79-year-old woman who was treated with antituberculosis therapy for 5 weeks was admitted to our unit for pancreatitis. Usual etiologies of pancreatitis were eliminated. Because of vomiting, antituberculosis therapy was withdrawn and symptoms disappeared. Eight days later, the same treatment was reintroduced and the patient presented recurrent pancreatitis; thus, treatment was withheld again followed by disappearance of clinical and biological abnormalities. Two days later, a treatment without isoniazid was reintroduced and no recurrence of symptoms was observed.
  
  
  CONCLUSIONS
  We have experienced a case of isoniazid induced pancreatitis. This is a rare cause of pancreatitis but potentially fatal thus recognition of drug induced pancreatitis and definitive withdrawal of the drug is required.
authors.affiliation: Department of Infectious Diseases, University of Paris 13. Bobigny, France. mattionis@yahoo.fr
authors.forename: Sarah
authors.initials: S
authors.lastname: Mattioni
authors.forename: Michele
authors.initials: M
authors.lastname: Zamy
authors.forename: Frederic
authors.initials: F
authors.lastname: Mechai
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Raynaud
authors.forename: Amelie
authors.initials: A
authors.lastname: Chabrol
authors.forename: Vanessa
authors.initials: V
authors.lastname: Aflalo
authors.forename: Michel
authors.initials: M
authors.lastname: Biour
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouchaud
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D055502:Secondary Prevention; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy; D028761:Withholding Treatment
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid