title: Targeting nanoparticles to dendritic cells for immunotherapy.
abstract: Dendritic cells (DCs) are key players in the initiation of adaptive immune responses and are currently exploited in immunotherapy for treatment of cancer and infectious diseases. Development of targeted nanodelivery systems carrying vaccine components, including antigens and adjuvants, to DCs in vivo represents a promising strategy to enhance immune responses. Delivering particulate vaccines specifically to DCs and preventing nonspecific uptake by other endocytotic cells are challenging. Size represents a critical parameter determining whether particulate vaccines can penetrate lymph nodes and reach resident DCs. Specific delivery is further enhanced by actively targeting DC-specific receptors. This chapter discusses the rationale for the use of particle-based vaccines and provides an overview of antigen-delivery vehicles currently under investigation. In addition, we discuss how vaccine delivery systems may be developed, focusing on liposomes, PLGA polymers, and gold nanoparticles, to obtain safe and efficacious vaccines.
authors.affiliation: Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Cruz
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Tacken
authors.forename: Felix
authors.initials: F
authors.lastname: Rueda
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Domingo
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Carl G
authors.initials: CG
authors.lastname: Figdor
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D055910:Antibodies, Immobilized / Q000737:chemistry; D000941:Antigens / Q000737:chemistry / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006046:Gold / Q000737:chemistry; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry; D007167:Immunotherapy / Q000379:methods*; D019344:Lactic Acid; D008081:Liposomes / Q000737:chemistry; D008969:Molecular Sequence Data; D053769:Nanocapsules / Q000737:chemistry*; D058726:Nanoconjugates / Q000737:chemistry; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014614:Vaccines, Synthetic / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D055910:Antibodies, Immobilized; D000941:Antigens; D007141:Immunoglobulin Fc Fragments; D008081:Liposomes; D053769:Nanocapsules; D058726:Nanoconjugates; D014614:Vaccines, Synthetic; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D006046:Gold