title: Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke.
abstract: BACKGROUND
  The alpha2-adrenergic receptor (α2-AR) mediates physiological responses to endogenous catecholamine, and genetic variants of α2-AR may predispose to clinical vascular diseases. We evaluated whether common genetic variants of each three subtype of alpha2-adrenergic receptor (ADRA2A, ADRA2B, and ADRA2C) were associated with ischemic stroke.
  
  
  METHODS
  A total of 616 patients with ischemic stroke and 512 controls were genotyped for the ADRA2A 1780G>A, ADRA2B 301-303 I/D, and ADRA2C 322-325 I/D polymorphisms. Logistic regression analyses, adjusting for multiple comparisons, were used to determine the association between the minor allele of each of three ADRA2 genes and the risk of ischemic stroke and pathophysiological subtypes.
  
  
  RESULTS
  The ADRA2B 301-303 D allele was more prevalent in the stroke group, compared to controls (DD vs. II, OR: 1.78, 95% CI: 1.18-2.69; recessive, OR: 1.55, 95% CI: 1.06-2.26). A subgroup analysis revealed that this association was found only in the small vessel diseases (SVD) type (DD vs. II, OR: 1.92, 95% CI: 1.11-3.33). The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype.
  
  
  CONCLUSIONS
  The ADRA2B 301-303 D allele confers an increased risk of overall ischemic stroke and SVD subtype.
authors.affiliation: Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea. ohsh72@chamc.co.kr
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Oh
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Min
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Mi-Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: Ok-Joon
authors.initials: OJ
authors.lastname: Kim
authors.forename: Byoung-Soo
authors.initials: BS
authors.lastname: Shin
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.forename: Nam-Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000483:Alleles; D002545:Brain Ischemia / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*
chemical_list: D018341:Receptors, Adrenergic, alpha-2