title: [Inhomogeneous hippocampal activation along the rostrocaudal axis in mice after exploration of novel environment].
abstract: Levels of the c-Fos protein expression in neurons were used as an index of neural activation in the hippocampus of C57BL/6 mice after their exploration of novel environments. C-Fos expression was measured at 8 levels along the rostrocaudal axis of the hippocampus. In Experiment 1, C57BL/6 mice were trained in a modified 8-arm radial maze to find the entry to a home cage through a target arm (1 day, 6 trials). Animals of control group were trained to enter the home cage through an isolated arm. In mice trained in 8-arm maze, functional rostrocaudal inhomogeneity of hippocampus was found. C-Fos expression was increased, mainly, in the caudal parts of CA1, CA3 and dentate gyrus as compared to the control group. In Experiment 2, C57BL/6 mice were tested (1 day, 6 trials) in a novel open-field arena. In this case, c-Fos activity was increased in CA1 (to a greater extent in the caudal than in rostral parts) and CA3 and dentate gyrus (equally in rostrocaudal direction). Significant positive correlations between the exploration activity and density of c-Fos positive cells were found in both experiments. The findings suggest that exploration in novel environment differentially affects the hippocampal subfields along the hippocampal rostrocaudal axis.
authors.forename: P A
authors.initials: PA
authors.lastname: Kuptsov
authors.forename: M G
authors.initials: MG
authors.lastname: Pleskacheva
authors.forename: K V
authors.initials: KV
authors.lastname: Anokhin
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000378:metabolism / Q000502:physiology; D056654:CA3 Region, Hippocampal / Q000378:metabolism / Q000502:physiology; D018891:Dentate Gyrus / Q000378:metabolism / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D013028:Space Perception / Q000502:physiology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos