title: CACG: a database for comparative analysis of conjoined genes.
abstract: A conjoined gene is defined as one formed at the time of transcription by combining at least part of one exon from each of two or more distinct genes that lie on the same chromosome, in the same or opposite orientation, which translate independently into different proteins. We comparatively studied the extent of conjoined genes in thirteen genomes by analyzing the public databases of expressed sequence tags and mRNA sequences using a set of computational tools designed to identify conjoined genes on the same DNA strand or opposite DNA strands of the same genomic locus. The CACG database, available at http://cgc.kribb.re.kr/map/, includes a number of conjoined genes (7131-human, 2-chimpanzee, 5-orangutan, 57-chicken, 4-rhesus monkey, 651-cow, 27-dog, 2512-mouse, 263-rat, 1482-zebrafish, 5-horse, 29-sheep, and 8-medaka) and is very effective and easy to use to analyze the evolutionary process of conjoined genes when comparing different species.
authors.affiliation: Genome Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.
authors.forename: Dae-Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Dong-Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Min-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Seong-Hyeuk
authors.initials: SH
authors.lastname: Nam
authors.forename: Sang-Haeng
authors.initials: SH
authors.lastname: Choi
authors.forename: Ryong Nam
authors.initials: RN
authors.lastname: Kim
authors.forename: Aram
authors.initials: A
authors.lastname: Kang
authors.forename: Aeri
authors.initials: A
authors.lastname: Kim
authors.forename: Hong-Seog
authors.initials: HS
authors.lastname: Park
mesh_terms: D000818:Animals; D002417:Cattle; D002645:Chickens; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D004285:Dogs; D005091:Exons / Q000235:genetics; D020224:Expressed Sequence Tags; D016678:Genome; D023281:Genomics; D006736:Horses; D006801:Humans; D008253:Macaca mulatta; D051379:Mice; D009990:Oryzias; D002679:Pan troglodytes; D010802:Phylogeny; D057079:Pongo; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D012756:Sheep; D015027:Zebrafish
chemical_list: D012333:RNA, Messenger