title: Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers.
abstract: OBJECTIVE
  The purpose of this study was to compare the biliary enhancement dynamics of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid (Gd-EOB-DTPA) and mangafodipir trisodium (Mn-DPDP) for contrast-enhanced MR cholangiography (MRC) in healthy subjects.
  
  
  METHODS
  15 healthy volunteers underwent MRI at 1.5 T with volumetric interpolated breath-hold examination sequence. Each volunteer was scanned once for each contrast agent. The signal-to-noise ratio (SNR) of the liver parenchyma and common hepatic duct (CHD) and the contrast-to-noise ratio (CNR) of CHD to liver parenchyma were evaluated and compared before and at several time points (5, 15, 30, 45, 60, 90, and 120 min) after injection of each agent.
  
  
  RESULTS
  SNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP in liver parenchyma after 5 min and in CHD after 15 min (p<0.05). CNR of CHD to liver parenchyma using Gd-EOB-DTPA showed an initial decrease at 5 min post-injection followed by a steep increase to a peak at 15 min post-injection. CNR using Mn-DPDP showed a steady increase to a peak at 15 min post-injection without an initial decrease. At 15 min, the value of CNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP (p<0.05).
  
  
  CONCLUSIONS
  For both contrast agents, CNR reached a peak at 15 min after contrast injection. At this time point, CNR of Gd-EOB-DTPA was significantly higher than that of Mn-DPDP. Therefore, Gd-EOB-DTPA may provide better contrast-enhanced MRC than Mn-DPDP at 15 min after contrast administration.
authors.affiliation: Department of Radiology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: K
authors.initials: K
authors.lastname: Bae
authors.forename: J B
authors.initials: JB
authors.lastname: Na
authors.forename: D S
authors.initials: DS
authors.lastname: Choi
authors.forename: J M
authors.initials: JM
authors.lastname: Cho
authors.forename: H C
authors.initials: HC
authors.lastname: Choi
authors.forename: K-N
authors.initials: KN
authors.lastname: Jeon
authors.forename: M J
authors.initials: MJ
authors.lastname: Park
authors.forename: H Y
authors.initials: HY
authors.lastname: Choi
authors.forename: J E
authors.initials: JE
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Chung
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000033:anatomy & histology*; D002758:Cholangiography / Q000379:methods*; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008297:Male; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; D019786:Gadolinium DTPA; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid