title: Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons.
abstract: We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, Strasbourg, France. g.lamanna@ibmc-cnrs.unistra.fr
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lamanna
authors.forename: Julie
authors.initials: J
authors.lastname: Russier
authors.forename: Hélène
authors.initials: H
authors.lastname: Dumortier
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects* / Q000276:immunology; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry; D004357:Drug Synergism; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D051379:Mice
chemical_list: D000893:Anti-Inflammatory Agents; D050091:Dendrimers; D007052:Ibuprofen