title: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
abstract: The role of metazoan coactivator SAYP in nuclear receptor-driven gene activation in the ecdysone cascade of Drosophila is considered. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex. The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription. DHR3 and SAYP interact during development and have multiple common targets across the genome.
authors.forename: N E
authors.initials: NE
authors.lastname: Vorob'eva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Nikolenko
authors.forename: A N
authors.initials: AN
authors.lastname: Krasnov
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Kuz'mina
authors.forename: V V
authors.initials: VV
authors.lastname: Panov
authors.forename: E N
authors.initials: EN
authors.lastname: Nabirochkina
authors.forename: S G
authors.initials: SG
authors.lastname: Georgieva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Shidlovskiĭ
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics; D002875:Chromosomes / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D004440:Ecdysone / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D055785:Gene Knockdown Techniques; D053263:Gene Regulatory Networks; D008675:Metamorphosis, Biological / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; C106186:Hr3 protein, Drosophila; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C499490:e(y)3 protein, Drosophila; D004440:Ecdysone