title: Review of the molecular profile and modern prognostic markers for gastric lymphoma: how do they affect clinical practice?
abstract: Primary gastric lymphoma is a rare cancer of the stomach with an indeterminate prognosis. Recently, a series of molecular prognostic markers has been introduced to better describe this clinical entity. This review describes the clinical importance of several oncogenes, apoptotic genes and chromosomal mutations in the initiation and progress of primary non-Hodgkin gastric lymphoma and their effect on patient survival. We also outline the prognostic clinical importance of certain cellular adhesion molecules, such as ICAM and PECAM-1, in patients with gastric lymphoma, and we analyze the correlation of these molecules with apoptosis, angiogenesis, tumour growth and metastatic potential. We also focus on the host-immune response and the impact of Helicobacter pylori infection on gastric lymphoma development and progression. Finally, we explore the therapeutic methods currently available for gastric lymphoma, comparing the traditional invasive approach with more recent conservative options, and we stress the importance of the application of novel molecular markers in clinical practice.
authors.affiliation: 1st Department of Propaedeutic Surgery, Hippokration Hospital of Athens, Athens Medical School, Vasilissis, Sofia Avenue 114, 11527, Athens, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Alevizos
authors.forename: Ilias P
authors.initials: IP
authors.lastname: Gomatos
authors.forename: Spyridon
authors.initials: S
authors.lastname: Smparounis
authors.forename: Manousos M
authors.initials: MM
authors.lastname: Konstadoulakis
authors.forename: Georgios
authors.initials: G
authors.lastname: Zografos
mesh_terms: D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008967:Molecular Biology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human; D025521:Tumor Suppressor Proteins; D019010:Vascular Cell Adhesion Molecule-1