title: The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty four months.
abstract: We examined the association between prenatal and postnatal exposure to PCBs and development at age 24 months as measured by the Bayley Scales of Infant Development II. 44 (85%) of 52 children had information available. When prenatal and postnatal exposure were modeled together, we found no association between total PCB exposure and the mental development index (MDI) or the physical development index (PDI). In examining PCB 153, we found no association between PCB 153 and MDI, while higher levels of postnatal exposure was associated with a decrease in PDI after adjustment [β for highest tertile=-24.9; 95% CI (-44.3, -5.5)]. Higher levels of prenatal PCB 153 exposure were associated with a statistically significant increased odds of screening positive for a motor delay. In sum, when prenatal and postnatal exposures were considered together, breast milk exposure to PCB 153 appears to be associated with decrements in motor development; however, we cannot rule out that the finding was due to chance.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH 43210, United States. courtney.lynch@osumc.edu
authors.forename: Courtney D
authors.initials: CD
authors.lastname: Lynch
authors.forename: Leila W
authors.initials: LW
authors.lastname: Jackson
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Kostyniak
authors.forename: Bridget M
authors.initials: BM
authors.lastname: McGuinness
authors.forename: Germaine M
authors.initials: GM
authors.lastname: Buck Louis
mesh_terms: D000328:Adult; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D008895:Milk, Human / Q000737:chemistry; D009048:Motor Skills / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D004785:Environmental Pollutants; D008055:Lipids; D011078:Polychlorinated Biphenyls