title: Activity of telavancin compared to other agents against coagulase-negative staphylococci with different resistotypes by time kill.
abstract: Among 10 coagulase-negative staphylococci, telavancin, quinupristin/dalfopristin, and tigecycline were the most potent antimicrobials. Telavancin exhibited bactericidal effect to 9 strains out of 10 tested at 4× MIC after 24 h of exposure similar to those of vancomycin and daptomycin. By contrast, linezolid was mainly bacteriostatic and teicoplanin was bactericidal to 7 strains tested at 4× MIC after 24 h.
authors.affiliation: Hershey Medical Center, Hershey, PA 17033, USA
authors.forename: Gengrong
authors.initials: G
authors.lastname: Lin
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Pankuch
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: Klaudia
authors.initials: K
authors.lastname: Kosowska-Shick
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003030:Coagulase / Q000378:metabolism; D006801:Humans; D000077427:Lipoglycopeptides; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects*; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003030:Coagulase; D000077427:Lipoglycopeptides; C487637:telavancin