title: [The influence of vascular remodeling and endothelial vasomotor function on the efficacy of indapamide retard in patients with hypertensive disease].
abstract: The influence of vascular remodeling and endothelial vasomotor function on the efficacy of indapamide retard was studied in 92 patients (49 men and 43 women) with stage I-II hypertensive disease and grade I-II arterial hypertension by observation of dynamics of the results of 24 hour AP monitoring and heart rhythm variability (HRV), cardio- and vasoprotective efects. The patients were divided into comparable groups. Group 1 was comprised of 40 patients without structural changes of the humeral artery (HA), group 2 included 52 patients undergoing HA remodeling. It was shown that antihypertensive efect of indapamide was virtually identical in both groups. Dynamics of left ventricular and HA structural/functional characteristics in group 2 was more pronounced than in group 1. Conversely, changes of spectral and time-dependent characteristics of HRV in group I were more significant than in group 2; they included suppression of reciprocal hyperactivity of the sympathetic nervous system. In the absence of structural vascular changes, the anti-hypertensive, cardio- and vasoprotective effects of indapamide retard were realized via neurohumoral blockade whereas direct vascular action of the drug prevailed in case of vascular remodeling and endothelial dysfunction
authors.forename: B G
authors.initials: BG
authors.lastname: Iskenderov
authors.forename: O N
authors.initials: ON
authors.lastname: Sisina
authors.forename: S V
authors.initials: SV
authors.lastname: Saushkina
authors.forename: L V
authors.initials: LV
authors.lastname: Kazantseva
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology*; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D007190:Indapamide