title: Chemical structure of phenothiazines and their biological activity.
abstract: Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural compounds. Apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade, phenothiazine derivatives also exert diverse biological activities, which account for their cancer chemopreventive-effect, as: calmodulin- and protein kinase C inhibitory-actions, anti-proliferative effect, inhibition of P-glycoprotein transport function and reversion of multidrug resistance. According to literature data on relations between chemical structure of phenothiazines and their biological effects, the main directions for further chemical modifications have been established. They are provided and discussed in this review paper.
authors.affiliation: Department of Basic Medical Sciences, Wrocław Medical University, Kochanowskiego 14, PL 51-601 Wrocław, Poland. agataj@basmed.am.wroc.pl
authors.forename: Agata
authors.initials: A
authors.lastname: Jaszczyszyn
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Gąsiorowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Świątek
authors.forename: Wiesław
authors.initials: W
authors.lastname: Malinka
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Cieślik-Boczula
authors.forename: Joanna
authors.initials: J
authors.lastname: Petrus
authors.forename: Bogusława
authors.initials: B
authors.lastname: Czarnik-Matusewicz
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry* / Q000494:pharmacology*; D018890:Chemoprevention; D018432:Drug Resistance, Multiple; D010640:Phenothiazines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D010640:Phenothiazines