title: Click-click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures.
abstract: The use of a peptidic template and orthogonal oxime ligation and CuAAC reaction allows a stepwise approach for the design of antiparallel tetrameric DNA structure. As a proof of concept template assisted synthesis of i-motif DNA was achieved. As anticipated, a dramatic improvement in the stability of such a tetrameric structure was observed. More interestingly the formation of the i-motif was still observed at neutral pH, which could be attributed to the spatial proximity of the basic centers.
authors.affiliation: Département de Chimie Moléculaire UMR CNRS 5250, Université Joseph Fourier BP 53, 38041 Grenoble cedex 9, France.
authors.forename: Romaric
authors.initials: R
authors.lastname: Bonnet
authors.forename: Pierre
authors.initials: P
authors.lastname: Murat
authors.forename: Nicolas
authors.initials: N
authors.lastname: Spinelli
authors.forename: Eric
authors.initials: E
authors.lastname: Defrancq
mesh_terms: D057930:Click Chemistry; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008026:Ligation; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D010091:Oximes; D010455:Peptides; D003300:Copper; D004247:DNA