title: Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found.
abstract: Asialoglycoprotein receptor (ASGPR) has attracted the attention of liver immunologists for many years. This liver-specific lectin was found to be a major B and T cell autoantigenic target in patients with autoimmune liver diseases, and in particular in autoimmune hepatitis (AIH). This review discusses the biological significance of ASGPR and its relevance to the pathogenesis of autoimmune and virus-triggered liver diseases. We also discuss emerging data on the diagnostic and clinical relevance of anti-ASGPR antibodies in light of recent reports based on commercially available anti-ASGPR enzyme-linked immunosorbent assays. Finally, we critically revisit the data reporting on disease-specific cellular immune responses against ASGPR and their relevance in relation to the pathogenesis of AIH.
authors.affiliation: Department of Medicine, University Hospital of Larissa, University of Thessaly Medical School, Viopolis 41110, Larissa, Greece. eirigopoulou@med.uth.gr
authors.forename: Eirini I
authors.initials: EI
authors.lastname: Rigopoulou
authors.forename: Dirk
authors.initials: D
authors.lastname: Roggenbuck
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Smyk
authors.forename: Christos
authors.initials: C
authors.lastname: Liaskos
authors.forename: Maria G
authors.initials: MG
authors.lastname: Mytilinaiou
authors.forename: Eugen
authors.initials: E
authors.lastname: Feist
authors.forename: Karsten
authors.initials: K
authors.lastname: Conrad
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Bogdanos
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000276:immunology* / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology* / Q000378:metabolism; D015551:Autoimmunity; D019693:Hepatitis, Autoimmune / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D011485:Protein Binding / Q000276:immunology
chemical_list: D037263:Asialoglycoprotein Receptor; D001323:Autoantibodies; D001324:Autoantigens