title: Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca2+ influx in rat glioma C6 cells.
abstract: Maitotoxin (MTX) is a ladder-shaped polyether produced by the epiphytic dinoflagellate Gambierdiscus toxicus. It is known to elicit potent toxicity against mammals and induce influx of Ca(2+) into cells. An artificial ladder-shaped polyether possessing a 6/7/6/6/7/6/6 heptacyclic ring system, which was designed for elucidating interactions with transmembrane proteins, was found to be the most potent inhibitor against MTX-induced Ca(2+) influx that has ever been reported.
authors.affiliation: Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan. oishi@chem.kyushu-univ.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Oishi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Konoki
authors.forename: Rie
authors.initials: R
authors.lastname: Tamate
authors.forename: Kohei
authors.initials: K
authors.lastname: Torikai
authors.forename: Futoshi
authors.initials: F
authors.lastname: Hasegawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsumori
authors.forename: Michio
authors.initials: M
authors.lastname: Murata
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D005910:Glioma / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D017136:Ion Transport / Q000187:drug effects; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D008565:Membrane Proteins / Q000378:metabolism; D035964:Oxocins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats; D014407:Tumor Cells, Cultured; D000095702:Polyether Toxins
chemical_list: D002118:Calcium; D004988:Ethers, Cyclic; D008387:Marine Toxins; D008565:Membrane Proteins; D035964:Oxocins; C020394:maitotoxin; D000095702:Polyether Toxins