title: Poor quality of life is associated with increased mortality in maintenance hemodialysis patients: a prospective cohort study.
abstract: Despite all developments in hemodialysis (HD), the mortality rate is still apparently higher than that in the general population, and worse health-related quality of life (HRQOL) is associated with increased mortality. We prospectively investigated the mortality status of HD patients during a five-year period and the association between mortality, HRQOL, laboratory parameters and clinical and sociodemographic characteristics at baseline. At the end of the five years, 293 patients out of 420 patients were still on HD treatment and 127 patients died. Those who died had a higher mean age, lower mean values of serum creatinine and albumin, higher prevalence of diabetes mellitus, received more HD twice weekly for less than 4 h in almost all HD sessions and had lower HRQOL than the survivors. We conclude that age, comorbidity, HD sessions lasting less than 4 h, malnutrition [hypoalbuminemia, low body mass index (BMI)] and lower physical component scores of SF-36 survey (PCS) were associated with higher risk of death in the HD population.
authors.affiliation: Department of Nephrology, Konya Research and Training Hospital, Konya, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Guney
authors.forename: Huseyin
authors.initials: H
authors.lastname: Atalay
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Solak
authors.forename: Lutfullah
authors.initials: L
authors.lastname: Altintepe
authors.forename: H Zeki
authors.initials: HZ
authors.lastname: Tonbul
authors.forename: Suleyman
authors.initials: S
authors.lastname: Turk
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000419:Albuminuria / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016009:Chi-Square Distribution; D015897:Comorbidity; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000401:mortality; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000401:mortality; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000097:blood / Q000401:mortality* / Q000523:psychology / Q000628:therapy*; D008297:Male; D044342:Malnutrition / Q000401:mortality; D008875:Middle Aged; D015995:Prevalence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011788:Quality of Life; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D003404:Creatinine