title: RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing.
abstract: The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.
authors.affiliation: Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular, y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina.
authors.forename: Manuel
authors.initials: M
authors.lastname: de la Mata
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Muñoz
authors.forename: Mariano
authors.initials: M
authors.lastname: Alló
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Fededa
authors.forename: Ignacio E
authors.initials: IE
authors.lastname: Schor
authors.forename: Alberto R
authors.initials: AR
authors.lastname: Kornblihtt