title: Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children.
abstract: Previous studies conducted in adult obese patients have shown that glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms influence cortisol-driven obesity and metabolic parameters. We investigated the impact of these polymorphisms in prepubertal obese children that were thoroughly examined for hypothalamic-pituitary-adrenal axis activity and for metabolic and obesity parameters. Obese children carrier of the allele G of the BclI polymorphism within glucocorticoid receptor gene tend to present a higher percentage of fat mass as well as a decreased cortisol suppression after low-dose dexamethasone as found in adult studies. Additionally, these allele G carriers show a strong correlation between truncal fat mass distribution and cortisol response to a standardized lunch, whereas this correlation is weak in allele C carriers. No differences were found for obesity or metabolic parameters between genotypes at the corticosteroid-binding globulin locus. However, allele 90 carriers present increased 24-h free urinary cortisol. Overall, this study provides new data showing the influence of glucocorticoid receptor and corticosteroid-binding globulin genes in obesity and/or cortisol action in prepubertal obese children.
authors.affiliation: Université Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286 Bordeaux, France. Pascal.Barat@chu-bordeaux.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Barat
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Corcuff
authors.forename: Maïté
authors.initials: M
authors.lastname: Tauber
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moisan
mesh_terms: D050154:Adiposity / Q000235:genetics*; D050218:Body Fat Distribution; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D006579:Heterozygote; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000652:urine; D012150:Polymorphism, Restriction Fragment Length; D011627:Puberty; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D014156:Transcortin / Q000235:genetics*
chemical_list: D011965:Receptors, Glucocorticoid; C534935:SERPINA6 protein, human; D014156:Transcortin; D006854:Hydrocortisone