title: Effect of intravitreal bevacizumab injection before vitrectomy on proliferative diabetic retinopathy.
abstract: OBJECTIVE
  To evaluate the effect of intravitreal bevacizumab (IVB) injection 1 week before pars plana vitrectomy (PPV) in proliferative diabetic retinopathy (PDR) patients.
  
  
  METHODS
  A retrospective research was done on 46 PDR patients who were divided into PPV group (n=28) and IVB group (n=18, PPV with preoperative IVB). Bevacizumab was injected 1 week before PPV. Main outcome measures were visual acuity, incidence of iatrogenic retinal breaks, intraoperative and postoperative bleeding.
  
  
  RESULTS
  At 1 month after surgery, visual acuity in PPV (82.1%) and IVB group (88.9%) improved significantly (P<0.01) and the difference between the two groups was not significant (P>0.05). Iatrogenic retinal breaks were reported in 18 cases (64.3%) in PPV group and 4 cases (22.2%) in IVB group (P<0.05). Intraoperative bleeding was encountered in all cases in PPV group and 7 cases (39%) in IVB group (P<0.01). Postoperative bleeding was reported in 9 cases (32.1%) in PPV group and none in IVB group (P<0.01).
  
  
  CONCLUSIONS
  IVB injection before PPV is helpful in reducing iatrogenic retinal breaks, intraoperative and postoperative bleeding in PDR patients.
authors.affiliation: Department of Ophthalmology, Hospital of Dali University, Dali 671000, Yunnan Province, China.
authors.forename: Cai-Rui
authors.initials: CR
authors.lastname: Li
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Hong