title: A-to-I RNA editing: effects on proteins key to neural excitability.
abstract: RNA editing by adenosine deamination is a process used to diversify the proteome. The expression of ADARs, the editing enzymes, is ubiquitous among true metazoans, and so adenosine deamination is thought to be universal. By changing codons at the level of mRNA, protein function can be altered, perhaps in response to physiological demand. Although the number of editing sites identified in recent years has been rising exponentially, their effects on protein function, in general, are less well understood. This review assesses the state of the field and highlights particular cases where the biophysical alterations and functional effects caused by RNA editing have been studied in detail.
authors.affiliation: Institute of Neurobiology and Department of Biochemistry, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00901, USA.
authors.forename: Joshua J C
authors.initials: JJ
authors.lastname: Rosenthal
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeburg
mesh_terms: D000241:Adenosine / Q000235:genetics / Q000378:metabolism; D000818:Animals; D055592:Biophysical Phenomena / Q000235:genetics; D006801:Humans; D007473:Ion Channels; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D017393:RNA Editing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D007473:Ion Channels; D011506:Proteins; D012333:RNA, Messenger; D000241:Adenosine