title: Antidepressant use in pregnancy and persistent pulmonary hypertension of the newborn (PPHN): a systematic review.
abstract: BACKGROUND
  An association between PPHN and antidepressant use in pregnancy has been reported.
  
  
  OBJECTIVE
  We sought to examine this relationship.
  
  
  METHODS
  A review of the literature was performed, to evaluate this association.
  
  
  RESULTS
  Six published studies fulfilled our criteria for inclusion, with only three studies large enough to have the power to detect an association. There appears to be a small but significantly, increased risk of late pregnancy SSRI exposure associated with PPHN in one case-control study; OR 5.1 (95% CI, 1.9-13.3) and two large cohort studies; RR 2.56; (95% CI, 1.17-4.85) and OR 2.1 (95% CI, 1.5-3.0) The other three studies did not find an association.
  
  
  CONCLUSIONS
  the absolute risk cannot be determined, but it is very small, probably less than 1%. If a pregnant woman requires pharmacological treatment, this information does not support discontinuation or lowering the dose of the antidepressant.
authors.affiliation: The Motherisk Program, Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Canada.
authors.forename: Geert W
authors.initials: GW
authors.lastname: 't Jong
authors.forename: Thomas
authors.initials: T
authors.lastname: Einarson
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Adrienne
authors.initials: A
authors.lastname: Einarson
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000139:chemically induced*; D011247:Pregnancy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors