title: Proposed role of primary protein carbonylation in cell signaling.
abstract: Reactive oxygen species (ROS) mediate various cell signaling processes, but the mechanism for how ROS promote cell signaling is poorly understood. Protein carbonylation occurs because of the direct metal-catalyzed oxidation of amino acid side chains (primary protein carbonylation) or  the addition of reactive aldehydes to amino acid side chains (secondary protein carbonylation). We hypothesize that primary protein carbonylation plays a role in the mechanism of ROS signaling. Specifically, we propose that (i) primary protein carbonylation mediates cell signaling and (ii)  primary protein carbonylation is reversible.
authors.affiliation: Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA.
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Wong
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Bansal
authors.forename: Lucia
authors.initials: L
authors.lastname: Marcocci
authors.forename: Yuichiro J
authors.initials: YJ
authors.lastname: Suzuki
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D002384:Catalysis; D019332:Endothelin-1 / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology; D008954:Models, Biological; D010084:Oxidation-Reduction; D050050:Protein Carbonylation; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000596:Amino Acids; D019332:Endothelin-1; D006834:Hydrazines; D008670:Metals; D017382:Reactive Oxygen Species; C446799:dinitrophenylhydrazine