title: Palladium catalyzed carbonylative Heck reaction affording monoprotected 1,3-ketoaldehydes.
abstract: The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl methyl ketones. The presented strategy can also be adapted for the facile and efficient incorporation of (13)C-labeled carbon monoxide.
authors.affiliation: Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University , Langelandsgade 140, 8000 Aarhus C, Denmark.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gøgsig
authors.forename: Dennis U
authors.initials: DU
authors.lastname: Nielsen
authors.forename: Anders T
authors.initials: AT
authors.lastname: Lindhardt
authors.forename: Troels
authors.initials: T
authors.lastname: Skrydstrup
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002247:Carbon Isotopes / Q000737:chemistry; D002248:Carbon Monoxide / Q000032:analysis / Q000737:chemistry; D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D002247:Carbon Isotopes; D006847:Hydrocarbons, Iodinated; D007659:Ketones; D010165:Palladium; D002248:Carbon Monoxide