title: Interest and attitudes of patients, cancer physicians, medical students and cancer researchers towards a spectrum of genetic tests relevant to breast cancer patients.
abstract: The perspectives of patients and healthcare professionals towards breast cancer genetic tests that are becoming increasingly available is unexplored in Asians. We surveyed the interest and attitudes of 200 breast cancer patients, 67 cancer physicians, 485 medical students and cancer researchers towards three genetic tests, BRCA1/2 mutation, CYP2D6 genotype and Oncotype DX testing, using hypothetical scenarios. Approximately 60% of patients expressed initial interest in each genetic test, although the majority reversed their decisions once test limitations were conveyed, with <15% maintaining interest in each test. Cancer physicians were most likely to recommend BRCA1/2 mutation testing (73%) and least likely to recommend CYP2D6 genotyping (12%), while patients were more likely to choose Oncotype DX testing (28%) over CYP2D6 (21%) and BRCA1/2 testing (15%). Cost concerns, low educational level and lack of prior awareness of genetic testing were the main barriers against breast cancer genetic testing among Asian patients.
authors.affiliation: Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Natalie
authors.initials: N
authors.lastname: Ngoi
authors.forename: Soo-Chin
authors.initials: SC
authors.lastname: Lee
authors.forename: Mikael
authors.initials: M
authors.lastname: Hartman
authors.forename: Lay-Wai
authors.initials: LW
authors.lastname: Khin
authors.forename: Andrea
authors.initials: A
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001291:Attitude of Health Personnel; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D015331:Cohort Studies; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000523:psychology*; D005820:Genetic Testing; D019538:Health Care Surveys; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010342:Patient Acceptance of Health Care / Q000523:psychology* / Q000706:statistics & numerical data; D010820:Physicians / Q000523:psychology; D012108:Research Personnel / Q000523:psychology; D012846:Singapore; D013337:Students, Medical / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D005819:Genetic Markers; D019389:Cytochrome P-450 CYP2D6