title: BRCT domains: A little more than kin, and less than kind.
abstract: BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.
authors.affiliation: Department of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA.
authors.forename: Dietlind L
authors.initials: DL
authors.lastname: Gerloff
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Woods
authors.forename: April A
authors.initials: AA
authors.lastname: Farago
authors.forename: Alvaro N A
authors.initials: AN
authors.lastname: Monteiro
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D019313:BRCA1 Protein / Q000737:chemistry*; D003198:Computer Simulation; D004249:DNA Damage; D015894:Genome, Human; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D010766:Phosphorylation; D010802:Phylogeny; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D015398:Signal Transduction; D055672:Static Electricity
chemical_list: D019313:BRCA1 Protein; D008024:Ligands; D011506:Proteins