title: Study of perioperative liver function by dynamic monitoring of ICG-clearance.
abstract: OBJECTIVE
  To investigate the impact of liver resection on the perioperative hepatic function by evaluation of ICG-clearance.
  
  
  METHODS
  Twenty-five patients underwent major hepatic resection (Group A) and 36 underwent minor hepatic resection (Group B). Thirteen patients who received no liver surgery, acted as control group (Group C). ICG-clearance measured by a non-invasive technique was expressed in terms of plasma disappearance rate (PDR-ICG-%/min) and retention rate of ICG 15 min (ICG-R15-%) after administration ICG (0.5mg/kg) before anesthesia induction (T0), immediately after the surgery (T1) and 24h after (T2).
  
  
  RESULTS
  There was statistically significant differences between the three groups: ICG-PDR (p<0.004) and ICG-R15 (p<0.040). These differences were observed between groups A and C at T1, between A and B, or A and C, at T2 for ICG-PDR and between groups A and B at T2 for ICG-R15. There were no differences between groups for hemoglobin, platelets, PT, creatinine, albumin, total protein, bilirubin and ALP.
  
  
  CONCLUSIONS
  ICG clearance is a safe non-invasive dynamic tool to quantify the liver function in patients following hepatic surgery. It also can be used to evaluate the liver surgery impact on hepatic function which can help to diagnose early hepatic dysfunction and guide the therapeutic decision making process.
authors.affiliation: Department of Surgery, Surgery 3, Coimbra, Portugal. jglrt@hotmail.com
authors.forename: José Guilherme
authors.initials: JG
authors.lastname: Tralhao
authors.forename: Emir
authors.initials: E
authors.lastname: Hoti
authors.forename: Barbara
authors.initials: B
authors.lastname: Oliveiros
authors.forename: Maria Filomena
authors.initials: MF
authors.lastname: Botelho
authors.forename: Fransisco Castro
authors.initials: FC
authors.lastname: Sousa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D007208:Indocyanine Green; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009017:Morbidity; D059035:Perioperative Period
chemical_list: D007208:Indocyanine Green