title: Enhanced intrinsic radiosensitivity after treatment with stereotactic radiosurgery for an acoustic neuroma.
abstract: Enhanced radiosensitivity is an uncommon phenomenon attributable to deficient DNA repair after radiotherapy which can be assessed with the γ-H2AX assay. Reports of radiosensitivity after stereotactic radiosurgery (SRS) are uncommon. We describe a case where the clinical, radiological and laboratory findings suggest enhanced radiosensitivity after SRS for an acoustic neuroma.
authors.affiliation: Department of Radiation Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. adams_gerard@hotmail.com
authors.forename: Gerard
authors.initials: G
authors.lastname: Adams
authors.forename: Olga A
authors.initials: OA
authors.lastname: Martin
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Roos
authors.forename: Pavel N
authors.initials: PN
authors.lastname: Lobachevsky
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Potter
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Zacest
authors.forename: Eva
authors.initials: E
authors.lastname: Bezak
authors.forename: William M
authors.initials: WM
authors.lastname: Bonner
authors.forename: Roger F
authors.initials: RF
authors.lastname: Martin
authors.forename: Trevor
authors.initials: T
authors.lastname: Leong
mesh_terms: D000368:Aged; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006657:Histones / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009464:Neuroma, Acoustic / Q000378:metabolism / Q000532:radiotherapy* / Q000601:surgery*; D011836:Radiation Tolerance; D016634:Radiosurgery
chemical_list: C468783:H2AX protein, human; D006657:Histones