title: Association between blood glucose levels and high-sensitivity cardiac troponin T in an overt cardiovascular disease-free community-based study.
abstract: OBJECTIVE
  To investigate the relationship between blood glucose levels and high-sensitivity cardiac troponin T (hs-cTnT) in an overt cardiovascular disease-free community-based study.
  
  
  METHODS
  Cardiac troponin T levels were measured using a highly sensitive assay in 1365 individuals, aged 45 years or older, without overt cardiovascular disease in a community-based, cross-sectional study, in Beijing, China. All participants underwent anthropometric measurements, biochemical analysis and an oral glucose tolerance test.
  
  
  RESULTS
  Both the prevalence of detectable hs-cTnT (≥3.0 pg/mL) and elevated hs-cTnT (≥13.3 pg/mL) were significantly higher in patients with diabetes mellitus (DM) than in patients with normal glucose tolerance (NGT), and those with impaired glucose regulation (IGR). After adjustment for multiple factors, the prevalence of detectable hs-cTnT (adjusted OR=1.22) and elevated hs-cTnT (adjusted OR=1.29) in the DM group were still significantly higher than in the NGT group. hs-cTnT was related to multiple risk factors for cardiovascular events, and fasting blood glucose level was an independent predictor of hs-cTnT.
  
  
  CONCLUSIONS
  hs-cTnT showed a varied distribution in a community-based population with different blood glucose levels. Both the prevalence of detectable hs-cTnT and elevated hs-cTnT were increased significantly in the diabetic population. hs-cTnT was related to multiple risk factors for cardiovascular events, and fasting blood glucose level was an independent predictor of hs-cTnT.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Fuxing Road 28, Beijing 100853, China. zhengjin622@sohu.com
authors.forename: Jin
authors.initials: J
authors.lastname: Zheng
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012907:Smoking / Q000097:blood* / Q000453:epidemiology; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020107:Troponin T