title: Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with N₂O₂ diazadioxa macrocycles.
abstract: A new series of diazadioxa oxovanadium(IV) macrocyclic complexes of type [VO(mac)]SO(4) have been synthesized via the condensation reaction of a 3-(phenyl/substituted phenyl)-4-amino-5-hydrazino-1,2,4-triazole (H(2)L) with salicylaldehyde/2-hydroxyacetophenone and 1,4-dibromobutane in the presence of oxovanadium(IV) sulfate in ethanol. All the newly synthesized compounds were characterized on the basis of elemental analyses, conductance measurements, magnetic properties, spectral (UV-Vis, IR, EPR) and XRD studies. The particle size of the complexes has been calculated from XRD spectra using Debye-Scherrer formula and these are found to be in 31-32 nm range. The efficacy of two macrocyclic complexes was also studied in streptozotocin-induced diabetic rats over a period of 30 days. The administration of these complexes in diabetic rats reversed the diabetic effect due to their insulin-mimetic effects.
authors.affiliation: Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273009, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Sharma
authors.forename: S K
authors.initials: SK
authors.lastname: Sengupta
authors.forename: O P
authors.initials: OP
authors.lastname: Pandey
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D004146:Dioxanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005951:Glucose Tolerance Test; D006454:Hemoglobins / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D009585:Nitrogen Dioxide / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D014508:Urea / Q000097:blood; D014638:Vanadates / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D056831:Coordination Complexes; D004146:Dioxanes; D006454:Hemoglobins; D007328:Insulin; D047028:Macrocyclic Compounds; C075743:oxovanadium IV; D014638:Vanadates; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D009585:Nitrogen Dioxide