title: Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis.
abstract: Hepatocellular adenomas (HCA) have been recently identified as a heterogeneous group, differing based on genotypic as well as morphological characteristics. HCA are most frequently found in women on oral contraception. A type of HCA, inflammatory HCA, is also known as telangiectatic HCA and was previously referred to as telangiectatic focal nodular hyperplasia. We present the first case of HCA arising from the liver with primary sclerosing cholangitis (PSC). This case is a 30-year-old man with a past medical history of PSC, ulcerative colitis and diabetes mellitus. A routine ultrasonography for PSC detected the gradually enlarged intrahepatic mass. Liver biopsy could reveal the diagnosis of telangiectatic/ inflammatory HCA by morphological and immunohistochemical analyses. Partial hepatectomy was performed and the resected liver was pathologically diagnosed as the telangiectatic/inflammatory HCA arising in PSC. This is the first case report of such an association and here we review the current developments and published work of this rare tumor and the association with an activated inflammatory related tumorogenic pathway and PSC.
authors.affiliation: Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa             Internal Medicine             Surgery             Radiology, Fukui Kosei Hospital, Fukui, Japan.
authors.forename: Hsu
authors.initials: H
authors.lastname: Maylee
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Saya
authors.initials: S
authors.lastname: Igarashi
authors.forename: Gen
authors.initials: G
authors.lastname: Tohda
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Xiang Shan
authors.initials: XS
authors.lastname: Ren
authors.forename: Takeshi
authors.initials: T
authors.lastname: Osawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Norio
authors.initials: N
authors.lastname: Takahashi
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma