title: Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ.
abstract: The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly expressed in the syncytiotrophoblast and extravillous cytotrophoblast cells. It has a key role in trophoblast invasion, as shown by studies in vitro, but its precise role during placentation remains to be elucidated, and fetomaternal outcomes of FPLD3 pregnancies also need to be assessed. This report is of a novel missense heterozygous mutation of PPARγ identified during pregnancy in a young diabetic woman who, at 3weeks of amenorrhoea, prematurely delivered a baby who died 24 h later. Histopathological analysis revealed important vascular placental abnormalities. The presence of the PPARγ mutation in placental tissues in the absence of fetal malformations and maternal hypertension suggests that FPLP3 pregnancies may be at high-risk, especially if the fetus has inherited the mutation. It also supports a physiological role for PPARγ during placentation.
authors.affiliation: Service d'endocrinologie, diabétologie et reproduction, Inserm U1065, hôpital l'Archet, CHU de Nice, BP 3079, 06202 Nice cedex 3, France.
authors.forename: A L
authors.initials: AL
authors.lastname: Castell
authors.forename: S
authors.initials: S
authors.lastname: Hiéronimus
authors.forename: O
authors.initials: O
authors.lastname: Lascols
authors.forename: T
authors.initials: T
authors.lastname: Fournier
authors.forename: P
authors.initials: P
authors.lastname: Fénichel
mesh_terms: D017809:Fatal Outcome; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000235:genetics*; D052496:Lipodystrophy, Familial Partial / Q000235:genetics* / Q000378:metabolism; D020125:Mutation, Missense; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism; D010920:Placenta / Q000002:abnormalities* / Q000098:blood supply / Q000378:metabolism; D010929:Placentation / Q000235:genetics; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult
chemical_list: D047495:PPAR gamma