title: Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models.
abstract: Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.
authors.affiliation: Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Natalie O
authors.initials: NO
authors.lastname: Karpinich
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Hoopes
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Kechele
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Lenhart
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Caron