title: PEDF in diabetic retinopathy: a protective effect of oxidative stress.
abstract: Diabetic retinopathy (DR) is a major cause of blindness in working age adults, and oxidative stress plays a vital role in the pathogenesis of DR. Pigment-epithelium-derived factor (PEDF), a multifunctional protein, has shown to inhibit the development of DR by accumulating evidence. This paper highlights the current understanding of probable mechanism about how PEDF blocks the deterioration of DR through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in DR. Gene therapy of PEDF is becoming more and more acceptable and will widely be applied to the actual treatment in the near future.
authors.affiliation: Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zhu
authors.forename: Hai-dong
authors.initials: HD
authors.lastname: Zou
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism*; D018384:Oxidative Stress; D015843:Serpins / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D000975:Antioxidants; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor