title: Some pharmacological actions of 'nimbidin'- a bitter principle of azadirachta indica-a juss (neem).
abstract: Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihistaminic (H1-receptor), anti 5 HT and antinicotinic activities. But in-vivo tests did not show any anticholinergic or anti-histaminic activity. Nimbidin possessed moderate diuretic activity and was found to be devoid of local anaesthetic and antiandrogenic effects in rodents.
authors.affiliation: C.D.R.S. Pharmacological Unit, Department of Pharmacology, Medical College Trivandrum - 695011 India.
authors.forename: N R
authors.initials: NR
authors.lastname: Pillai
authors.forename: G
authors.initials: G
authors.lastname: Santhakumari
authors.forename: J
authors.initials: J
authors.lastname: Laping