title: 5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in the guinea pigs eyes with spectacle lens-induced myopia.
abstract: OBJECTIVE
  To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM).
  
  
  METHODS
  Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye).
  
  
  RESULTS
  LIM eyes formed significant myopia with longer axial length. 5-HT level in retina, choroids and sclera from LIM eyes was significantly higher than that in control group. 5-HT2A mRNA expression was also significantly up-regulated.
  
  
  CONCLUSIONS
  Refraction lens could induce myopia in guinea pig and 5-HT may play an important role in the formation of myopia by binding with 5-HT2A receptor.
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Ji-Wen
authors.initials: JW
authors.lastname: Yang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Tian