title: Late onset necrotizing enterocolitis in infants following use of a xanthan gum-containing thickening agent.
abstract: Adverse event reports submitted to the US Food and Drug Administration suggested a possible association between necrotizing enterocolitis and ingestion of a commercial feed thickener by premature infants. Review in 2011 of 22 cases with exposure revealed a distinct illness pattern.
authors.affiliation: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Riverdale, MD 20770, USA. Jennifer.Beal@fda.hhs.gov
authors.forename: Jennifer
authors.initials: J
authors.lastname: Beal
authors.forename: Benson
authors.initials: B
authors.lastname: Silverman
authors.forename: Jodeanne
authors.initials: J
authors.lastname: Bellant
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Young
authors.forename: Karl
authors.initials: K
authors.lastname: Klontz
mesh_terms: D003680:Deglutition Disorders / Q000628:therapy; D020345:Enterocolitis, Necrotizing / Q000139:chemically induced* / Q000175:diagnosis / Q000382:microbiology; D005503:Food Additives / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000628:therapy; D008895:Milk, Human; D011135:Polysaccharides, Bacterial / Q000009:adverse effects*
chemical_list: D005503:Food Additives; D011135:Polysaccharides, Bacterial; C002563:xanthan gum