title: Microwave assisted synthesis of Py-Im polyamides.
abstract: Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5'-WGWWCW-3' (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Puckett
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Green
authors.forename: Peter B
authors.initials: PB
authors.lastname: Dervan
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles