title: Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.
abstract: BACKGROUND
  High fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized.
  
  
  OBJECTIVE
  This study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1β (Ire1β) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice.
  
  
  RESULTS
  We used Ire1β-deficient mice to assess the contribution of intestinal lipid absorption to atherosclerosis. Here, we show that Ire1b(-/-)/Apoe(-/-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more lipids, exhibit hyperlipidemia, and have higher levels of atherosclerotic plaques compared with Apoe(-/-) mice when fed chow and western diets.
  
  
  CONCLUSIONS
  These studies indicate that Ire1β regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis.
authors.affiliation: Department of Cell Biology, Box 5, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA. jahangir.iqbal@downstate.edu
authors.forename: Jahangir
authors.initials: J
authors.lastname: Iqbal
authors.forename: Joyce
authors.initials: J
authors.lastname: Queiroz
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xian-Cheng
authors.initials: XC
authors.lastname: Jiang
authors.forename: David
authors.initials: D
authors.lastname: Ron
authors.forename: M Mahmood
authors.initials: MM
authors.lastname: Hussain
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004041:Dietary Fats / Q000378:metabolism; D006949:Hyperlipidemias / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D007408:Intestinal Absorption / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency* / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; D004041:Dietary Fats; D008565:Membrane Proteins; C486556:Ern2 protein, mouse; D017346:Protein Serine-Threonine Kinases