title: Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba.
abstract: A new flavanone derivative, malaysianone A (1), four prenylated flavanones, 6-prenyl-3'-methoxyeriodictyol (2), nymphaeol B (3), nymphaeol C (4) and 6-farnesyl-3',4',5,7-tetrahydroxyflavanone (5), and two coumarins, 5,7-dihydroxycoumarin (6) and scopoletin (7), were isolated from the dichloromethane extract of the inflorescences of Macaranga triloba. The structures of these compounds were elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D), UV, IR and mass spectrometry. The cytotoxic activity of the compounds was tested against several cell lines, with 5 inhibiting very strongly the growth of HeLa and HL-60 cells (IC(50): 1.3 μg/ml and 3.3 μg/ml, respectively). Compound 5 also showed strong antiplasmodial activity (IC(50): 0.06 μM).
authors.affiliation: Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.
authors.forename: Ishak
authors.initials: I
authors.lastname: Zakaria
authors.forename: Norizan
authors.initials: N
authors.lastname: Ahmat
authors.forename: Faridahanim M
authors.initials: FM
authors.lastname: Jaafar
authors.forename: Aty
authors.initials: A
authors.lastname: Widyawaruyanti
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D044950:Flavanones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D056626:Inflorescence; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C575155:6-farnesyl-3',4',5,7-tetrahydroxyflavanone; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D044950:Flavanones; D010936:Plant Extracts