title: Phytol-derived novel isoprenoid immunostimulants.
abstract: This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice.
authors.affiliation: Department of Biology, Indiana State University Terre Haute, IN, USA.
authors.forename: Roshni Roy
authors.initials: RR
authors.lastname: Chowdhury
authors.forename: Swapan K
authors.initials: SK
authors.lastname: Ghosh