title: Correlation between serum H2S and pulmonary function in children with             bronchial asthma.
abstract: Endogenous hydrogen sulfide (H2S) has generated recent research interest because of its potential function as an inflammatory mediator. Despite its apparent functions in vascular smooth muscle, an important player in airway remodeling in asthma, little research has been done to assess the role of H2S in the pathogenesis of asthma. To determine whether serum H2S concentration is correlated with pulmonary function in children with asthma, we measured serum H2S concentration and pulmonary function indices (FVC, FEV1, PEF, FEF25-75, MEF50 and MEF25) in 64 children with asthma and 60 healthy children. Pearson's correlation was used to determine the relationship between serum H2S concentration and lung function parameters. Compared to healthy children, both serum H2S concentration and all lung function parameters were significantly decreased in children with asthma (P<0.05). Furthermore, serum H2S concentration was positively correlated with lung function indices (P<0.05). Thus, decreasing levels of H2S in the serum may be used to indicate decreasing lung function. Further investigation into the causality behind these findings is required.
authors.affiliation: Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing, Jiangsu 210008, PR China. tmsweet2012@126.com
authors.forename: Man
authors.initials: M
authors.lastname: Tian
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Lu
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Yan-He
authors.initials: YH
authors.lastname: Jiang
authors.forename: De-Yu
authors.initials: DY
authors.lastname: Zhao
mesh_terms: D001249:Asthma / Q000097:blood / Q000473:pathology*; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D018836:Inflammation Mediators / Q000097:blood; D008168:Lung / Q000737:chemistry* / Q000503:physiopathology*; D008297:Male; D010366:Peak Expiratory Flow Rate; D012129:Respiratory Function Tests
chemical_list: D018836:Inflammation Mediators; D006862:Hydrogen Sulfide