title: The emerging role of CXC chemokines and their receptors in cancer.
abstract: Chemokines and their receptors have a multifaceted role in tumor biology and are implicated in nearly all aspects of cancer growth, survival and dissemination. Modulation of the interaction between chemokines and their cell surface receptor is, therefore, a promising area for the development of new cancer medicines. In this review, we look at the compelling evidence that is emerging to support targeting CXC chemokines, also known as family α chemokines, as novel therapeutic strategies in the treatment of cancer.
authors.affiliation: Institute of Cancer Therapeutics, Tumbling Hill Street, Bradford, BD7 1DP, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Vinader
authors.forename: Kamyar
authors.initials: K
authors.lastname: Afarinkia
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D019743:Chemokines, CXC / Q000235:genetics / Q000276:immunology*; D055808:Drug Discovery / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D054387:Receptors, CXCR / Q000235:genetics / Q000276:immunology*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D019743:Chemokines, CXC; D054387:Receptors, CXCR; D054852:Small Molecule Libraries