title: Pressurized-liquid extraction for determination of illicit drugs in hair by LC-MS-MS.
abstract: An LC-MS-MS-based procedure for determination in hair of 14 different drugs of abuse belonging to the classes cocaine, amphetamine-like compounds, opiates, and hallucinogens has been developed. A pressurized-liquid extraction procedure was used and proved useful for quantitative recovery of all the analytes tested. This procedure, in conjunction with a simple decontamination step, performed to avoid false-positive samples, enabled the detection of all the analytes with LOQ ranging from 1.8 to 16 pg mg(-1) and accuracy varying from 85 to 111 %. The procedure was validated in accordance with the SOFT/AAFS guidelines and seems to be suitable for routine determination of the drugs tested in hair.
authors.affiliation: Department of Food Science, University of Teramo, Teramo, Italy.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sergi
authors.forename: Sabino
authors.initials: S
authors.lastname: Napoletano
authors.forename: Camilla
authors.initials: C
authors.lastname: Montesano
authors.forename: Roberto
authors.initials: R
authors.lastname: Iofrida
authors.forename: Roberta
authors.initials: R
authors.lastname: Curini
authors.forename: Dario
authors.initials: D
authors.lastname: Compagnone
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006197:Hair / Q000737:chemistry*; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis* / Q000302:isolation & purification*; D057230:Limit of Detection; D015813:Substance Abuse Detection / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D013287:Illicit Drugs