title: Rubesanolides C-E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity.
abstract: Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique γ-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Lutai
authors.initials: L
authors.lastname: Pan
authors.forename: Qiji
authors.initials: Q
authors.lastname: Li
authors.forename: Jianxin
authors.initials: J
authors.lastname: Pu
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Banas
authors.forename: Hongjie
authors.initials: H
authors.lastname: Zhang
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D018360:Crystallography, X-Ray; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry; D013290:Streptococcal Infections / Q000188:drug therapy; D013295:Streptococcus mutans / Q000187:drug effects / Q000502:physiology
chemical_list: D045784:Abietanes; D000900:Anti-Bacterial Agents