title: Neo-clerodane diterpenes from Salvia herbacea.
abstract: Chemical investigation of the aerial parts of Salvia herbacea led to the isolation of eight new neo-clerodane diterpenes (1-8), named tehuanins A-H, and three known compounds. The structures of these compounds were determined by analysis of their spectroscopic data. Three of the new diterpenes possess a 1,8-epoxy group (1-3). This unusual structural feature was confirmed by X-ray diffraction of 1. The structure of the previously isolated 1α,10α-epoxysalviarin was revised. The absolute configuration of 6 was established by X-ray diffraction analysis of its bromo derivative 6a. Cytotoxic and anti-inflammatory activities of these diterpenes were examined. None of the compounds were considered to be cytotoxic; however, compound 7 exhibited anti-inflammatory activity comparable to that of indomethacin.
authors.affiliation: Instituto de Química,  Universidad Nacional Autónoma de México , Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D. F., México.
authors.forename: Elihú
authors.initials: E
authors.lastname: Bautista
authors.forename: Emma
authors.initials: E
authors.lastname: Maldonado
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ortega
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology; D007213:Indomethacin / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008800:Mexico; D051379:Mice; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; D016859:Lipoxygenase Inhibitors; D007213:Indomethacin