title: [Protective effect of salvianolic acid B on isolated heart ischemia/reperfusion injury in rats].
abstract: OBJECTIVE
  To study the protective effect and mechanism of salvianolic acid B on isolated heart ischemia/reperfusion injury in rats.
  
  
  METHODS
  Forty-eight SD rats were divided into 6 groups randomly(n = 8): the control group, the positive administration group (verapamil 150 microg x L(-1)), and high, middle and low-dose salvianolic acid B groups (10, 5, 2.5 mg x L(-1)). The myocardial ischemia/reperfusion injury model was established using the Langendorff method, re-perusing isolated working hearts for 30 min after ischemia for 25 min. A water-bag catheter was inserted in rat left atrium for recording the effect of salvianolic acid B on hemodynamics indexes-AST, LDH, SOD and MDA.
  
  
  RESULTS
  Various group with different doses showed that salvianolic acid B decreased AST, release of LDH and formation of MDA and increased SOD activity.
  
  
  CONCLUSIONS
  Salvianolic acid B showed a protective effect on myocardial ischemia/reperfusion injury. Its mechanism may be related with improvement of cardiac contractility, cleaning of oxygen free radicals and reduction of lipid peroxidation.
authors.affiliation: The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Guibo
authors.initials: G
authors.lastname: Sun
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Ren
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Nie
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D053630:Depsides
chemical_list: D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D007770:L-Lactate Dehydrogenase; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C076944:salvianolic acid B; D053630:Depsides