title: Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones.
abstract: A highly efficient multi-component anion relay cascade reaction based on 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile has been developed, which provides strategically novel and atom-economic access to biologically important biscyanoethylated furo[3,2-c]pyridinones. In this one-pot transformation, up to five bonds (one C-N, one C-O and three C-C bonds) were constructed.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Lin
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.forename: Fushun
authors.initials: F
authors.lastname: Liang
authors.forename: Baozhong
authors.initials: B
authors.lastname: Zhao
authors.forename: Yanling
authors.initials: Y
authors.lastname: Liu
authors.forename: Pengjun
authors.initials: P
authors.lastname: Liu
mesh_terms: D000107:Acetylation; D000181:Acrylonitrile / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000577:Amides; D000838:Anions; D003486:Cyanides; D003521:Cyclopropanes; D011728:Pyridones; C017679:2-hydroxypyridine; D000181:Acrylonitrile; C538819:cyclopropanecarboxamide