title: The implications of positive peritoneal lavage cytology in potentially resectable pancreatic cancer.
abstract: BACKGROUND
  The clinical implications of peritoneal lavage cytology (CY) status in patients with potentially resectable pancreatic cancer have not been established.
  
  
  METHODS
  We retrospectively reviewed clinical data from 254 consecutive patients who underwent macroscopically curative resection for pancreatic cancer from February 2003 to December 2010 in our institution. Correlations between CY status and survival and clinicopathological findings were investigated.
  
  
  RESULTS
  Of the 254 patients, 20 were CY+ (7.9 %). There were no significant differences between CY+ and CY- patients in background data (age, sex, the level of preoperative tumor marker, and adjuvant chemotherapy). Patients with positive serosal invasion were more likely to be CY+ than those with negative serosal invasion (P < 0.001) by univariate analysis. The median overall survival of CY+ patients and CY- patients was 23.8 months (95 % CI = 17.6-29.8) and 26.5 months (95 % CI = 20.7-32.3), respectively (P = 0.302). The median recurrence-free survival of CY+ and CY- patients was 8.1 months (95 % CI = 0.0-17.9) and 13.5 months (95 % CI = 11.5-15.5), respectively (P = 0.089).
  
  
  CONCLUSIONS
  CY+ status without other distant metastasis does not necessarily preclude resection in patients with pancreatic cancer.
authors.affiliation: Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yoshioka
authors.forename: Akio
authors.initials: A
authors.lastname: Saiura
authors.forename: Rintaro
authors.initials: R
authors.lastname: Koga
authors.forename: Junichi
authors.initials: J
authors.lastname: Arita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takemura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ono
authors.forename: Junji
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome