title: King of hearts: a splicing factor rules cardiac proteins.
abstract: Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).
authors.affiliation: Department of Cardiovascular Physiology, Ruhr University Bochum, Germany. wolfgang.linke@rub.de
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Linke
authors.forename: Sandra
authors.initials: S
authors.lastname: Bücker
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D064211:Connectin; D006801:Humans; D009124:Muscle Proteins / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D064211:Connectin; D009124:Muscle Proteins; C573837:RBM20 protein, rat; D016601:RNA-Binding Proteins; C577285:TTN protein, human; C543725:ribonucleic acid binding motif protein 20, human; D011494:Protein Kinases