title: Synthesis of amino-substituted indoles using the Bartoli reaction.
abstract: We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli reaction is to our knowledge unprecedented. Our work thus represents a novel entry into substituted aminoindoles which are relevant building blocks for both the fine chemical and pharmaceutical industry.
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Wylie
authors.forename: Paolo
authors.initials: P
authors.lastname: Innocenti
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Whelligan
authors.forename: Swen
authors.initials: S
authors.lastname: Hoelder
mesh_terms: D000588:Amines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000588:Amines; D007211:Indoles