title: Predictive value of confocal scanning laser for the onset of visual field loss in glaucoma suspects.
abstract: OBJECTIVE
  To perform a longitudinal multivariate analysis of the ability of Moorfields Regression Analysis (MRA) to predict the onset of glaucoma in a population of patients with suspected glaucoma due to appearance of the optic nerve head.
  
  
  METHODS
  Prospective longitudinal evaluation of a diagnostic test.
  
  
  METHODS
  Single, randomly selected eye of prospectively recruited patients with suspected glaucoma based on the optic nerve head appearance on stereophotographs and normal baseline visual field results.
  
  
  METHODS
  The MRA was evaluated at baseline (Heidelberg Retina Tomograph; Heidelberg Engineering, Dossenheim, Germany), and visual field tests were repeated every 6 months. A longitudinal multivariate proportional hazard ratio (HR) analysis was performed, and likelihood ratios and positive and negative predictive values were compared.
  
  
  METHODS
  Onset of visual field losses.
  
  
  RESULTS
  The study included 230 eyes that were followed up during a mean period of 62±14 months, ranging from 4 to 7 years. The predicted HR (for onset of visual field losses) of the MRA temporal-inferior sector outside normal limits was 3.65 (95% confidence interval [CI], 2.32-5.75; P < 0.0001). An MRA temporal-superior sector outside normal limits had an HR of 3.43 (95% CI, 2.21-5.32; P < 0.0001).
  
  
  CONCLUSIONS
  The temporal-inferior and temporal-superior positions of the MRA are highly predictive for the onset of visual field loss in glaucoma suspects.
authors.affiliation: Miguel Servet University Hospital (Instituto Aragonés de Ciencias de la Salud), Zaragoza, Spain. jlarrosa@unizar.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Larrosa
authors.forename: Vicente
authors.initials: V
authors.lastname: Polo
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.forename: Laura
authors.initials: L
authors.lastname: Gil
authors.forename: Isabel
authors.initials: I
authors.lastname: Fuertes
authors.forename: Luis E
authors.initials: LE
authors.lastname: Pablo
mesh_terms: D005189:False Positive Reactions; D005500:Follow-Up Studies; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D016013:Likelihood Functions; D018613:Microscopy, Confocal; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis*; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests; D014794:Visual Fields