title: Leishmanicidal compounds from the fruits of Piper longum.
abstract: One new alkaloid amide, piperlongumide (1) [N-isobutyl-19-(3',4'-methylenedioxyphenyl)-2E,4E nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of Leishmania donovani were isolated from the n-hexane fraction of the fruits of Piper longum. The structure of 1 was elucidated by spectroscopic evidences.
authors.affiliation: Amity Institute of Biotechnology, Amity University, Noida, India. sabarighosal@gmail.com
authors.forename: Sabari
authors.initials: S
authors.lastname: Ghosal
authors.forename: Anindita
authors.initials: A
authors.lastname: Deb
authors.forename: Priyanka
authors.initials: P
authors.lastname: Mishra
authors.forename: Ram
authors.initials: R
authors.lastname: Vishwakarma
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D052117:Benzodioxoles / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007893:Leishmania donovani / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D052117:Benzodioxoles; D005231:Fatty Acids, Unsaturated; C575798:N-isobutyl-19-(3',4'-methylenedioxyphenyl)-2,4-nonadecadienamide