title: Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis.
abstract: Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.
authors.affiliation: Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, Colombia.
authors.forename: Eduard
authors.initials: E
authors.lastname: Baquero
authors.forename: Wiston
authors.initials: W
authors.lastname: Quiñones
authors.forename: Wellman
authors.initials: W
authors.lastname: Ribon
authors.forename: Maria Leonor
authors.initials: ML
authors.lastname: Caldas
authors.forename: Ladys
authors.initials: L
authors.lastname: Sarmiento
authors.forename: Fernando
authors.initials: F
authors.lastname: Echeverri