title: Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system.
abstract: This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects.
authors.affiliation: Sapienza University of Rome, Department of Chemistry and Technologies of Drug, Piazzale Aldo Moro, 5, 00185, Rome, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Fraschetti
authors.forename: Matthias C
authors.initials: MC
authors.lastname: Letzel
authors.forename: Antonello
authors.initials: A
authors.lastname: Filippi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Speranza
authors.forename: Jochen
authors.initials: J
authors.lastname: Mattay