title: Sister Mary Joseph's nodule associated with rare endometrial squamous cell carcinoma.
abstract: BACKGROUND
  Umbilical metastasis (Sister Mary Joseph's nodule) is a rare physical sign seen only in 1-3 % of patients with an intra-abdominal and/or pelvic malignancy. Here, we present a case of Sister Mary Joseph's (SMJN) nodule originating from a primary squamous cell carcinoma of the endometrium, a rare histological subtype.
  
  
  METHODS
  SMJN was detected in a 30-year-old woman after a preoperative CT scan for a suspected umbilical hernia. Subsequent laparotomy and histopathological examination confirmed endometrial squamous cell carcinoma metastasizing to the umbilical region.
  
  
  CONCLUSIONS
  The SMJN may be the first presenting sign of an intra-abdominal and/or pelvic malignancy and may co-exist with an umbilical hernia. Therefore, malignancy should be considered one of the differentials of an umbilical mass.
authors.affiliation: Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89-1 Enyacho, Izumo, Shimane, 6938501, Japan.
authors.forename: Mohammed Tanjimur
authors.initials: MT
authors.lastname: Rahman
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakayama
authors.forename: Munmun
authors.initials: M
authors.lastname: Rahman
authors.forename: Naomi
authors.initials: N
authors.lastname: Nakayama
authors.forename: Masako
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Katagiri
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katagiri
authors.forename: Tomoka
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Kouji
authors.initials: K
authors.lastname: Iida
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D058288:Sister Mary Joseph's Nodule / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D014472:Umbilicus / Q000000981:diagnostic imaging / Q000473:pathology*