title: Total synthesis of (±)-sorocenol B employing nanoparticle catalysis.
abstract: The total synthesis of (±)-sorocenol B has been accomplished featuring key steps including silver nanoparticle (AgNP)-catalyzed Diels-Alder cycloaddition and late-stage Pd(II)-catalyzed oxidative cyclization. The synthetic natural product exhibited low micromolar cytotoxic activity against a number of human cancer cell lines.
authors.affiliation: Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
authors.forename: Huan
authors.initials: H
authors.lastname: Cong
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; C587799:sorocenol B; D012834:Silver