title: Intraoperative sonographic localization of a fractured Supprelin implant in a pediatric patient: a case report.
abstract: The subdermal implant is an effective delivery system for the gonadotropin-releasing hormone analog histrelin in the treatment of central precocious puberty. In younger patients, implantation and replacement of the implant is performed under general anesthesia. This obviates the need for frequent intramuscular injections and has been shown to be preferable to patients and families. However, the implantation procedures have been complicated by fracture during surgical withdrawal. This paper discusses one such case and the intraoperative technique that led to effective withdrawal of the fractured implant.
authors.affiliation: Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Brett J
authors.initials: BJ
authors.lastname: Monroe
authors.forename: Sara C
authors.initials: SC
authors.lastname: Fallon
authors.forename: Mary L
authors.initials: ML
authors.lastname: Brandt
mesh_terms: D000279:Administration, Cutaneous; D002648:Child; D004343:Drug Implants / Q000009:adverse effects*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000188:drug therapy*
chemical_list: D004343:Drug Implants; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin