title: Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree study).
abstract: Previous angiographic studies have suggested that the future risk for major adverse cardiovascular events (MACEs) is related to coronary stenosis severity. The aim of this study was to use the grayscale and virtual histology (VH)-intravascular ultrasound (IVUS) data from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) study to identify underlying lesion morphologic characteristics that might explain these findings. In PROSPECT, patients presenting with acute coronary syndromes in whom percutaneous coronary intervention was successful underwent 3-vessel grayscale and VH-IVUS and were followed for a median of 3.4 years for the incidence of MACEs. Overall, 3,115 nonculprit lesions detected by IVUS were divided into quartiles according to baseline angiographic diameter stenosis. From the first to fourth quartiles, there were increases in the prevalence of lesions with IVUS minimum luminal areas ≤ 4 mm(2), IVUS plaque burden ≥ 70%, and VH-IVUS thin-cap fibroatheroma (13.4%, 22.0%, 24.2%, and 30.3%, respectively, p <0.001), along with an increased frequency of plaque ruptures and greater necrotic core volumes. The incidence of lesions with plaque burden ≥ 70%, minimum luminal area ≤ 4 mm(2), and VH thin-cap fibroatheroma was highest in the fourth quartile (0%, 0.4%, 0.4%, and 2.8% in the first through fourth quartiles, respectively, p <0.001). Three-year MACE rates were also highest in the fourth quartile (0.3%, 0.7%, 1.3%, and 5.1%, respectively, p <0.001). In conclusion, increasing angiographic diameter stenosis was associated with an increased frequency of grayscale and VH-IVUS lesion morphologic features that have been associated with adverse events and that may, in part, explain why future MACEs were related to baseline lesion severity.
authors.affiliation: Columbia University Medical Center, New York, New York, USA.
authors.forename: Kyeong Ho
authors.initials: KH
authors.lastname: Yun
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Naim
authors.initials: N
authors.lastname: Farhat
authors.forename: Steven P
authors.initials: SP
authors.lastname: Marso
authors.forename: Nevio
authors.initials: N
authors.lastname: Taglieri
authors.forename: Stefan
authors.initials: S
authors.lastname: Verheye
authors.forename: Michael C
authors.initials: MC
authors.lastname: Foster
authors.forename: M Pauliina
authors.initials: MP
authors.lastname: Margolis
authors.forename: Barry
authors.initials: B
authors.lastname: Templin
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Dressler
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D023921:Coronary Stenosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D018084:Ultrasonography, Interventional