title: Myocardial damage in dogs affected by heartworm disease (Dirofilaria immitis): immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs.
abstract: It has recently been reported that dogs affected by canine heartworm disease (Dirofilaria immitis) can show an increase in plasma levels of myoglobin and cardiac troponin I, two markers of muscle/myocardial injury. In order to determine if this increase is due to myocardial damage, the right ventricle of 24 naturally infected dogs was examined by routine histology and immunohistochemistry with anti-myoglobin and anti-cardiac troponin I antibodies. Microscopic lesions included necrosis and myocyte vacuolization, and were associated with loss of staining for one or both proteins. Results confirm that increased levels of myoglobin and cardiac troponin I are indicative of myocardial damage in dogs affected by heartworm disease.
authors.affiliation: Internal Medicine, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, 35413 Arucas, Las Palmas, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carretón
authors.forename: G
authors.initials: G
authors.lastname: Grandi
authors.forename: R
authors.initials: R
authors.lastname: Morchón
authors.forename: F
authors.initials: F
authors.lastname: Simón
authors.forename: B
authors.initials: B
authors.lastname: Passeri
authors.forename: A M
authors.initials: AM
authors.lastname: Cantoni
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.forename: J A
authors.initials: JA
authors.lastname: Montoya-Alonso
mesh_terms: D000818:Animals; D015415:Biomarkers; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000378:metabolism* / Q000469:parasitology / Q000473:pathology; D004283:Dog Diseases / Q000378:metabolism / Q000469:parasitology*; D004285:Dogs; D006331:Heart Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009211:Myoglobin / Q000097:blood* / Q000378:metabolism; D019210:Troponin I / Q000097:blood* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D019210:Troponin I