title: Multiple myeloma and bisphosphonate-related osteonecrosis of the mandible associated with dental implants.
abstract: Multiple myeloma (MM) is a malignant plasma cell disorder and more than 30% of patients with this pathology develop osteolytic lesions in the jaw. Either pamidronate or zoledronic acid is recommended in patients with MM who have one or more lytic lesions. However, bisphosphonate-related osteonecrosis of the jaws (BRONJ) has been described as a complication associated with their use. Otherwise, the use of endosseous implants in oral rehabilitation is a well-established procedure, with good long-term success although systemic factors may affect the bone healing around dental implants. We report the first case reported of MM adjacent to a mandibular dental implant in a patient who developed BRONJ in the same area after intravenous zoledronate treatment. We discuss possible pathogeny of this particular and interesting phenomena.
authors.affiliation: Oral and Maxillofacial Surgery, Dental School, University of Oviedo, Catedrático José Serrano Street, 33009 Oviedo, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Junquera
authors.forename: Lorena
authors.initials: L
authors.lastname: Gallego
authors.forename: Alejandro
authors.initials: A
authors.lastname: Pelaz