title: Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England.
abstract: The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A population-based study of serotypes causing invasive pneumococcal disease (IPD) post-PCV7 in North East England was conducted using data from a regional enhanced IPD surveillance system. Overall, there was a 20% reduction [95% confidence interval (CI) 5-32] from 12·1 cases/100 000 population in 2006/2007 to 9·7 in 2009/2010. There was a fall in IPD caused by PCV7 serotypes in all age groups, with reductions of 90% (95% CI 61-99) in children aged <5 years, 50% (95% CI 4-75) in persons aged 5-64 years and 66% (95% CI 40-82) in adults aged ⩾65 years. There was a non-significant increase in IPD caused by non-PCV7 serotypes in children aged <5 years of 88% (95% CI -10 to 312) and adults aged ⩾65 years of 12% (95% CI -19 to 50), which was largely caused by serotypes 7F, 19A and 22F. Replacement disease appears to have reduced the benefits of PCV7 in North East England.
authors.affiliation: Health Protection Agency North East, North East Regional Epidemiology Unit, Gallowgate, Newcastle upon Tyne, UK.
authors.forename: K E
authors.initials: KE
authors.lastname: Chapman
authors.affiliation: Health Protection Agency North East, North East Health Protection Unit, Gallowgate, Newcastle upon Tyne, UK.
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.affiliation: Health Protection Agency North East, North East Regional Epidemiology Unit, Gallowgate, Newcastle upon Tyne, UK.
authors.forename: R
authors.initials: R
authors.lastname: Gorton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004739:England; D062665:Epidemiological Monitoring; D006760:Hospitalization; D006801:Humans; D017589:Immunization Programs / Q000706:statistics & numerical data; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate