title: Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate.
abstract: Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers. With the recent introduction of monepantel (Zolvix®) and of derquantel plus abamectin (Startect®) in New Zealand, two new anthelmintic classes will be available to control gastrointestinal nematodes. While monepantel covers a broad spectrum of nematodes, the efficacy of derquantel is mid-spectrum and limited to a smaller number of species and stages. The combination of derquantel and abamectin allows to enlarge the spectrum and to cover most parasitic nematodes in sheep. However, the question remained open, if the efficacy of the new anthelmintics can be maintained in the presence of severe anthelmintic resistance. The present study investigated the efficacy against adult stages of a multi-resistant Haemonchus contortus isolate. While monepantel resulted in 100 % elimination, derquantel in combination with abamectin resulted in efficacies <95 % (faecal egg counts and worm counts).
authors.affiliation: Novartis Centre de Recherche Santé Animale, 1566 St. Aubin, Switzerland. heinz.sager@novartis.com
authors.forename: Heinz
authors.initials: H
authors.lastname: Sager
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bapst
authors.forename: Günther A
authors.initials: GA
authors.lastname: Strehlau
authors.forename: Ronald
authors.initials: R
authors.lastname: Kaminsky
mesh_terms: D000607:Aminoacetonitrile / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D006188:Haemonchiasis / Q000188:drug therapy*; D006189:Haemonchus / Q000187:drug effects*; D007211:Indoles / Q000008:administration & dosage* / Q000494:pharmacology; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010082:Oxepins / Q000008:administration & dosage* / Q000494:pharmacology; D010270:Parasite Egg Count; D012756:Sheep; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D007211:Indoles; D010082:Oxepins; C575297:derquantel; D000607:Aminoacetonitrile; C048324:abamectin; D007559:Ivermectin; C533978:monepantel