title: [Rehabilitation medicine, laboratory medicine, and hypertension--my 38-year academic career in Tohoku University and Hirosaki University].
abstract: Hypertension is a major contributor to the risks for cardiovascular diseases. The cause of approximately 90% of hypertension cases is unknown, despite decades of research and debate. Many factors including renal mechanisms and the renin-angiotensin system are involved in the regulatory mechanisms of blood pressure. Genetic and environmental factors interact to affect multiple factors related to hypertensive mechanisms. Recent data suggested that genetic risk factors have been useful in clinical practice. The evidence that treatment of hypertension reduces cardiovascular diseases come from the results of large-scale therapeutic trials. Significant progress has been made during the last several decades in the treatment of hypertension through the use of inhibitors of the renin-angiotensin system, with either angiotensin converting enzyme inhibitors or angiotensin receptor type 1 blockers. In this review, I summarize my personal career related to hypertension research.
authors.affiliation: Endowed Foundation Reimeikyo Hirosaki Stroke and Rehabilitation Center, Hirosaki 036-8104, Japan. m_yasujima@reimeikyou.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Yasujima
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000209:etiology; D053579:Gitelman Syndrome; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D007564:Japan; D013677:Medical Laboratory Science / Q000639:trends*; D011955:Receptors, Drug; D012084:Renin-Angiotensin System / Q000502:physiology; D012306:Risk; D049992:Sodium Chloride Symporters; D014495:Universities
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D011955:Receptors, Drug; D049992:Sodium Chloride Symporters; C064415:thiazide receptor