title: One new antitumour cassane-type diterpene from Caesalpinia crista.
abstract: 1α-acetoxy-5α, 7β-dihydroxycassa-11,13(15)-diene-16,12-lactone, a new cassane-type diterpene was isolated from Caesalpinia crista. The structure of this compound was elucidated by analysis of NMR spectra, and the relative configuration was established by NOE experiment. The new compound was evaluated for antitumour activity against T47D, DU145 and showed significant inhibitory activities.
authors.affiliation: Key Laboratory of Plant Resources Conservation and Utilization of Hunan Province, Jishou University, Jishou 416000, China. tianqijian68@163.com
authors.forename: Qi-Jian
authors.initials: QJ
authors.lastname: Tian
authors.forename: Yang-Hui
authors.initials: YH
authors.lastname: Ou
authors.forename: Xing-Bing
authors.initials: XB
authors.lastname: He
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Jiang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes