title: Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents.
abstract: Multiple myeloma (MM) comprises 1% of all malignancies and 13% of hematological malignancies in the Caucasian population. Yearly incidence is 4/100,000 in the US and is higher in blacks and males [1]. The pathogenesis of the disease is relatively unknown; several chromosomal abnormalities have been related to the development of the disease,but none is characteristic of MM. Cyclin-D1 is a protein encoded by the CCND1 (bcl-1) gene on chromosome 11q13, and is an important regulator of G1 to S phase progression.
authors.affiliation: Department of Hematopathology, "Evangelismos" General Hospital, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Tasidou
authors.forename: Maria
authors.initials: M
authors.lastname: Roussou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Terpos
authors.forename: Efstathios
authors.initials: E
authors.lastname: Kastritis
authors.forename: Maria
authors.initials: M
authors.lastname: Gkotzamanidou
authors.forename: Maria
authors.initials: M
authors.lastname: Gavriatopoulou
authors.forename: Magdalini
authors.initials: M
authors.lastname: Migkou
authors.forename: Evangelos
authors.initials: E
authors.lastname: Eleutherakis-Papaiakovou
authors.forename: Nikitas
authors.initials: N
authors.lastname: Nikitas
authors.forename: Dimitra
authors.initials: D
authors.lastname: Anagnostou
authors.forename: Meletios A
authors.initials: MA
authors.lastname: Dimopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D015331:Cohort Studies; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D016019:Survival Analysis; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D015415:Biomarkers; C530104:CCND1 protein, human; D012333:RNA, Messenger; D019938:Cyclin D1