title: Inflammatory response to orthopedic biomaterials after total hip replacement.
abstract: BACKGROUND
  The aim of the present study was to investigate early inflammatory response in the first 3 days after the implantation of hip prostheses, and to compare the early inflammation responses associated with the use of different combinations of bearing materials.
  
  
  METHODS
  34 patients were enrolled, all of whom underwent unilateral total hip replacement and had identical hip prostheses, except for the bearing materials. These consisted of polyethylene on alumina (n = 8), polyethylene on CoCr (n = 11), or alumina on alumina (n = 15). Blood samples were collected preoperatively in the morning of the day of surgery, and at 6 h, 1 day, 2 days, and 3 days postoperatively. CK, CRP, and IL-6 in peripheral blood were measured. Pain score was obtained at 2 days after surgery.
  
  
  RESULTS
  There were no significant differences in the pre- and postoperative background variables among the groups. Pain scores of different groups were not significantly different either (P > 0.05). There were also no significant differences in the levels of CK, CRP, and IL-6 when patients with the three combinations of bearing materials were compared.
  
  
  CONCLUSIONS
  We concluded that varying the bearing materials used in the hip prosthesis did not influence the early inflammatory response after prosthesis implantation.
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Bai
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: Yongyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kunzheng
authors.initials: K
authors.lastname: Wang
mesh_terms: D000537:Aluminum Oxide; D000704:Analysis of Variance; D019540:Area Under Curve; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D002097:C-Reactive Protein / Q000378:metabolism; D016009:Chi-Square Distribution; D002857:Chromium; D003035:Cobalt; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery*; D005549:Foreign-Body Reaction / Q000097:blood*; D006622:Hip Prosthesis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D020959:Polyethylene; D011446:Prospective Studies; D011474:Prosthesis Design
chemical_list: D015850:Interleukin-6; D002857:Chromium; D003035:Cobalt; D020959:Polyethylene; D002097:C-Reactive Protein; D000537:Aluminum Oxide