title: RNA-DNA sequence differences spell genetic code ambiguities.
abstract: A recent paper in Science by Li et al. 2011(1) reports widespread sequence differences in the human transcriptome between RNAs and their encoding genes termed RNA-DNA differences (RDDs). The findings could add a new layer of complexity to gene expression but the study has been criticized.
authors.affiliation: Department of Cellular and Molecular Medicine, The Novo Nordisk Center for Protein Research, University of Copenhagen, Copenhagen, Denmark. bentin@sund.ku.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Bentin
authors.forename: Michael L
authors.initials: ML
authors.lastname: Nielsen
mesh_terms: D004247:DNA / Q000235:genetics*; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D004247:DNA