title: Size dependence of molecular self-assembling in stacked aggregates. 1. NMR investigation of ciprofloxacin self-association.
abstract: One of the most important purposes in molecular technologies is the preparation of supramolecular structures by self-assembling processes. The aromatic molecules self-associate mainly in π-π stacked structures with an aggregate size distribution determined by the association equilibrium constants. A general expression for the equilibrium constants K(n,m) which govern the self-association of two aggregates with n and m monomers respectively has been obtained. The model predicts also the concentrations of free monomers, the concentrations of n-mers, and the total concentration of aggregates. (1)H NMR experiments have been used to illustrate the applicability of the proposed model in a particular case: π-stacking self-association of ciprofloxacin in solution.
authors.affiliation: Department of Molecular and Biomolecular Physics, National Institute of Isotopic and Molecular Technology, 400293 Cluj-Napoca, Romania. ioan.turcu@itim-cj.ro
authors.forename: Ioan
authors.initials: I
authors.lastname: Turcu
authors.forename: Mircea
authors.initials: M
authors.lastname: Bogdan
mesh_terms: D002939:Ciprofloxacin / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010316:Particle Size; D013816:Thermodynamics
chemical_list: D046911:Macromolecular Substances; D002939:Ciprofloxacin