title: Spatial analysis of eco-environmental risk factors of cutaneous leishmaniasis in Southern Iran.
abstract: BACKGROUND
  Despite the advances in the diagnosis and treatment of leishmaniasis, it is still considered as a severe public health problem particularly in developing countries and a great economic burden on the health resources. The present study was designed and conducted to determine the eco-environmental characteristics of the leishmaniasis disease by spatial analysis.
  
  
  METHODS
  In an ecological study, data were collected on eco-environmental factors of Fars province in Iran and on cutaneous leishmaniasis (CL) cases from 2002 to 2009. geographic weighted regression (GWR) was used to analyse the data and compare them with ordinary least square (OLS) regression model results. Moran's Index was applied for analysis of spatial autocorrelation in residual of OLS. P value less than 0.05 was considered as significant and adjusted R(2) was used for model preferences.
  
  
  RESULTS
  There was a significant spatial autocorrelation in the residuals of OLS model (Z=2.45, P=0.014). GWR showed that rainy days, minimum temperature, wind velocity, maximum relative humidity and population density were the most important eco-environmental risk factors and explained 0.388 of the associated factors of CL.
  
  
  CONCLUSIONS
  Spatial analysis can be a good tool for detection and prediction of CL disease. In autocorrelated and non-stationary data, GWR model yields a better fitness than OLS regression model. Also, population density can be used as a surrogate variable of acquired immunity and increase the adjusted R(2).
authors.affiliation: Department of Epidemiology, Health Faculty, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ali-Akbarpour
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Mohammadbeigi
authors.forename: Seyed Hamid Reza
authors.initials: SH
authors.lastname: Tabatabaee
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Hatam