title: Inhibition of miRNA-221 suppresses the airway inflammation in asthma.
abstract: This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy in the OVA-induced murine asthma model. miRNA-221 was differentially expressed in asthmatics and control subjects, and miRNA-221 blockade resulted in a reduction of airway inflammation in the OVA-induced murine asthma model. We conclude that miRNA-221 participates in the pathogenesis of asthma and that inhibition of miRNA-221 suppresses airway inflammation in asthmatics.
authors.affiliation: Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Hou-bing
authors.initials: HB
authors.lastname: Qin
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
authors.forename: Juan-juan
authors.initials: JJ
authors.lastname: Mei
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Juan-juan
authors.initials: JJ
authors.lastname: Liu
authors.forename: De-yu
authors.initials: DY
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D010047:Ovalbumin; D011897:Random Allocation; D012130:Respiratory Hypersensitivity / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D010047:Ovalbumin; C525709:MIR221, human