title: Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target.
abstract: Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.
authors.affiliation: Nephrology Division, Department of Medicine, University of Wisconsin, H4/564 CSC, 600 Highland Avenue, Madison, WI, 53792, USA. axd@medicine.wisc.edu.
authors.forename: Aparna
authors.initials: A
authors.lastname: Vidyasagar
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Wilson
authors.forename: Arjang
authors.initials: A
authors.lastname: Djamali