title: Graft loss due to recurrent disease in pediatric kidney transplant recipients on a rapid prednisone discontinuation protocol.
abstract: Recurrent disease is the fourth most common cause of graft loss (GL) in pediatric KTx recipients. We studied the incidence of recurrent disease and GL due to recurrent disease in pediatric KTx recipients on a RDP protocol. Between 2002 and 2010, we performed 74 KTxs in patients aged 5-18 yr using an RDP protocol, 25 (34%) were at risk of recurrence of primary disease. Outcomes were compared to 69 historical controls (18 [26%] at risk of recurrence), KTx between 1996 and 2000. Follow-up period was 39 ± 25 months in RDP and 124 ± 38 months in controls. The incidence of recurrent disease at three yr post-KTx was 16% in RDP and 28% in controls (p = NS). Mean time to recurrent disease was 22 ± 26 months in RDP and 46 ± 48 months in controls (p = 0.54). Nine (12%) grafts were lost in the RDP group (1-recurrence) and 32 (46%) in the control group (4-recurrence). Time to GL was 85 months in the RDP recipient and 46 ± 21 months in controls. An RDP protocol in pediatric KTx recipients may not be associated with increased risk of graft loss due to recurrent disease.
authors.affiliation: Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55454, USA. chave001@umn.edu
authors.forename: Blanche M
authors.initials: BM
authors.lastname: Chavers
authors.forename: Michelle N
authors.initials: MN
authors.lastname: Rheault
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Gillingham
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Matas
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology*; D012008:Recurrence; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000628:therapy*; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D011241:Prednisone