title: Porphyrin dyads linked by a rotatable 3,3'-biphenyl scaffold: a new binding motif for small ditopic molecules.
abstract: Synthetic access to a set of metallo- and free base bis-porphyrins has been provided by a stepwise approach involving sequential peptide and Suzuki couplings. Linking these porphyrins through a 3,3'-biphenyl bridge enables cooperative binding to ditopic ligands such as the bipyridyls. Association constants and binding stoichiometry has been determined by spectroscopic/spectrophotometric means and the differences in the binding affinities of a small series of diaza ligands is discussed in the context of structural fit and microscopic association constants.
authors.affiliation: School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Amy R
authors.initials: AR
authors.lastname: Mulholland
authors.forename: Pall
authors.initials: P
authors.lastname: Thordarson
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Mensforth
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Langford
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D019281:Dimerization; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry; D012399:Rotation; D015032:Zinc / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D008665:Metalloporphyrins; D011725:Pyridines; D015032:Zinc; C010574:biphenyl; C034306:4,4'-bipyridyl