title: Successful outcome of ganciclovir-resistant cytomegalovirus infection in organ transplant recipients after conversion to mTOR inhibitors.
abstract: Ganciclovir-resistant (GanR) cytomegalovirus (CMV) infection after organ transplantation is emerging as a significant therapeutic challenge. We report two cases of GanR CMV infection successfully managed by switching immunosuppression from calcineurin inhibitors to an mTOR inhibitor-based regimen. This salvage therapy should be considered when other options are not available.
authors.affiliation: Department of Infectious Disease, Institut d'Investigació Biomèdica de Bellvitge-Hospital Universitari de Bellvitge, University of Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Sabé
authors.forename: J
authors.initials: J
authors.lastname: González-Costello
authors.forename: I
authors.initials: I
authors.lastname: Rama
authors.forename: J
authors.initials: J
authors.lastname: Niubó
authors.forename: M
authors.initials: M
authors.lastname: Bodro
authors.forename: J
authors.initials: J
authors.lastname: Roca
authors.forename: J M
authors.initials: JM
authors.lastname: Cruzado
authors.forename: N
authors.initials: N
authors.lastname: Manito
authors.forename: J
authors.initials: J
authors.lastname: Carratalà
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D065095:Calcineurin Inhibitors; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D024882:Drug Resistance, Viral; D015774:Ganciclovir / Q000494:pharmacology*; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D015774:Ganciclovir