title: Preparation, chemical and electrical characterizations of lipid nanoparticles loaded with dihydroxybenzophenone.
abstract: Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHBLNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.
authors.affiliation: Dep. Química Orgánica, Facultad de Ciencias, Universidad de Málaga, E-29071 Málaga, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hierrezuelo
authors.forename: Juana
authors.initials: J
authors.lastname: Benavente
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: López-Romero
authors.forename: Maria del Valle
authors.initials: Mdel V
authors.lastname: Martínez de Yuso
authors.forename: Enrique
authors.initials: E
authors.lastname: Rodríguez-Castellón
mesh_terms: D001577:Benzophenones / Q000737:chemistry*; D002214:Capsules; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D055590:Electromagnetic Phenomena; D008055:Lipids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D056951:Photoelectron Spectroscopy
chemical_list: D001577:Benzophenones; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; C121479:2,4-dihydroxybenzophenone