title: Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population.
abstract: BACKGROUND
  Recent studies have suggested that common genetic polymorphisms alter the processing of microRNA (miRNA) and may be associated with the development and progression of cancer.
  
  
  METHODS
  The association of miRNA polymorphisms with HCC survival was analyzed in 159 HCC patients and 201 controls by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  The risk of HCC was significantly lower for the miR-499A>G, AG+GG in HCC patients (AOR=0.603, 95% CI=0.370-0.984) and hepatitis B virus (HBV)-related HCC patients (AOR=0.561, 95% CI 0.331-0.950). In addition, the risk of HCC was significantly lower for the miR-149C>T, CT and CT+CC in HCC patients (CT; AOR=0.542, 95% CI=0.332-0.886, CT+CC; AOR=0.536, 95% CI=0.335-0.858) and HBV-related HCC patients (CT: AOR=0.510, 95% CI 0.305-0.854, CT+CC: AOR=0.496, 95% CI 0.302-0.813). The miR-149C>T polymorphism was also associated with survival rate of HCC patients in OKUDA II stage.
  
  
  CONCLUSIONS
  miR-149C>T and miR-499A>G were associated with HBV-related HCC. Further studies on larger populations will need to be conducted to confirm these results.
authors.affiliation: Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Kim
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Min
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Chang-Il
authors.initials: CI
authors.lastname: Kwon
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Ko
authors.forename: Pil Won
authors.initials: PW
authors.lastname: Park
authors.forename: Sung Pyo
authors.initials: SP
authors.lastname: Hong
authors.forename: Kyu Seong
authors.initials: KS
authors.lastname: Rim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kwon
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000821:virology; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology / Q000235:genetics / Q000401:mortality / Q000821:virology; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D015996:Survival Rate
chemical_list: C542542:MIRN146 microRNA, human; C551557:MIRN149 microRNA, human; C542543:MIRN196 microRNA, human; C548683:MIRN499 microRNA, human; D035683:MicroRNAs; D004247:DNA