title: Synchronous bilateral infiltrating syringomatous adenoma of the breast.
abstract: Infiltrating syringomatous breast adenoma is an uncommon mammary neoplasm composed of angulated glandular structures with a variable amount of epidermoid differentiation which proliferate in a background of dense collagenous stroma. The patient presented with bilateral hardness and oedema of the nipples. Ultrasound and mammography revealed microcalcifications in retromammilary regions of both nipples. Histological examination of the resected specimens showed angulated glands and solid cords, lined by an inner layer of epithelial cells and an outer layer of myoepithelial cells, immersed in desmoplastic stroma. Within the solid cords reminiscent of squamous cells, occasionally aggregated in keratinizing cysts were found. To the best of our knowledge this is the first described case of bilateral infiltrating syringomatous breast adenoma with synchronous presentation. Infiltrating syringomatous adenoma is a rare lesion. A finding of infiltrating syringomatous adenoma in one breast should prompt careful examination of the opposite breast with adequate follow-up.
authors.affiliation: Department of Pathology, Cytology and Forensic Medicine, Split University Hospital Centre, Split,  Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Mrklić
authors.forename: J
authors.initials: J
authors.lastname: Bezić
authors.forename: Z
authors.initials: Z
authors.lastname: Pogorelić
authors.forename: N
authors.initials: N
authors.lastname: Ilić
authors.forename: T
authors.initials: T
authors.lastname: Tadić
authors.forename: V
authors.initials: V
authors.lastname: Buljević
authors.forename: S
authors.initials: S
authors.lastname: Tomić
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009558:Nipples / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D018252:Syringoma / Q000473:pathology*; D016896:Treatment Outcome