title: Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121).
abstract: Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD(-) and CAD(+) subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF(+) and LF(-) subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD(+) subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population.
authors.affiliation: Laboratory of Molecular Immunology, AU-KBC Research Centre, Anna University, Chennai, India. cvaravindhan@yahoo.co.uk
authors.forename: Vivekanandhan
authors.initials: V
authors.lastname: Aravindhan
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.forename: Jayagopi
authors.initials: J
authors.lastname: Surendar
authors.forename: Maradana Muralidhara
authors.initials: MM
authors.lastname: Rao
authors.forename: Rajamanickam
authors.initials: R
authors.lastname: Anuradha
authors.forename: Mohan
authors.initials: M
authors.lastname: Deepa
authors.forename: Subash
authors.initials: S
authors.lastname: Babu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000469:parasitology*; D004605:Elephantiasis, Filarial / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology / Q000469:parasitology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein