title: [Symbiotic relations of human and microorganisms].
abstract: Symbiosis has been considered as a biological basis of infectious process. Particular attention was paid to the change of paradigm in symbiology and the appearance of a novel term--associative symbiosis. Principal structural-and-functional elements of associative symbiosis were estimated, and 3 vectors of infectious process such as i) host--normaflora, ii) host--associants, iii) associants--indigious microflora (microsymbiocenosis) were isolated. Functions of microsymbionts that determine colonization resistance of the host, and the formation of dysbioses and pathobiocenoses were reviewed. Phenomenon of microbial recognition for "self-nonself" has been revealed on the basis of opportunistic (increase/decrease) interactions on growth persistent (including biofilm formation) peculiarities of a pair "dominant-associant" under conditions of microsymbiocenosis in human. Material was presented to characterize the role of intercellular interactions of symbionts at the level of prokaryotes, pro-eukaryotes under conditions of infectious pathology.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
authors.forename: N B
authors.initials: NB
authors.lastname: Perunova
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity*; D058448:Biota; D006790:Host-Parasite Interactions / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007239:Infections / Q000235:genetics / Q000382:microbiology*; D059013:Microbial Consortia / Q000502:physiology; D056265:Microbial Interactions / Q000502:physiology; D013559:Symbiosis