title: Existence of a nitric oxide synthase/nitric oxide system in fish testis and its role in modulation of androgenesis.
abstract: Fish testis is equipped with different isoforms of nitric oxide synthase (NOSs) and is capable of producing nitric oxide (NO). Cellular sources of NO in the catfish testis are germ cells, Leydig cells, and macrophages. Production of testicular NO is under endocrine inhibitory control. Expression of NOSs exhibits seasonality and that depends on the reproductive status of fish. Leydig cells are highly sensitive to chemical as well as biological NO. NO inhibits testosterone production by the testis in vivo as well as by the isolated Leydig cells in vitro.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, 221 005, India. lalbhu@yahoo.co.in
authors.forename: B
authors.initials: B
authors.lastname: Lal
authors.forename: N
authors.initials: N
authors.lastname: Dubey
mesh_terms: D000726:Androgen Antagonists / Q000378:metabolism*; D000818:Animals; D002397:Catfishes / Q000378:metabolism / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D007985:Leydig Cells / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology; D012621:Seasons; D013737:Testis / Q000201:enzymology*
chemical_list: D000726:Androgen Antagonists; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase