title: Misuse of medicines in the European Union: a systematic review of the literature.
abstract: BACKGROUND
  Although awareness of the misuse of medicines is increasing, data on the extent of the problem in the European Union (EU) are lacking.
  
  
  METHODS
  In order to assess the magnitude and severity of the problem, a systematic review of the literature on the misuse of analgesics, opioid substitution medicines and sedatives/hypnotics (with the exception of benzodiazepines) was conducted using the PubMed and Web of Science databases. Relevant literature was identified between 2001 and 2011.
  
  
  RESULTS
  The main groups of misused medicines include opioid analgesics, methadone, buprenorphine and Z-drugs. Regional trends in medicine misuse indicate heterogeneity across the EU with respect to misused medicine types and research activities. Prevalence, high-risk populations and factors contributing to medicine misuse are discussed.
  
  
  CONCLUSIONS
  The implications of these findings for prevention, treatment, and policy in the EU are considered.
authors.affiliation: Institut für Therapieforschung, Munich, Germany. casati@ift.de
authors.forename: Alicia
authors.initials: A
authors.lastname: Casati
authors.forename: Roumen
authors.initials: R
authors.lastname: Sedefov
authors.forename: Tim
authors.initials: T
authors.lastname: Pfeiffer-Gerschel
mesh_terms: D000701:Analgesics, Opioid; D005062:European Union / Q000706:statistics & numerical data; D006801:Humans; D006993:Hypnotics and Sedatives; D058850:Opiate Substitution Treatment; D009293:Opioid-Related Disorders / Q000453:epidemiology; D063487:Prescription Drug Misuse; D055553:Prescription Drugs; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology*
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D055553:Prescription Drugs