title: Patient-specific phosphorus mobilization clearance during nocturnal and short daily hemodialysis.
abstract: The kinetics of plasma phosphorus during different hemodialysis (HD) modalities are incompletely understood. We recently demonstrated that a pseudo one-compartment kinetic model including phosphorus mobilization from various body compartments into extracellular fluids can describe intradialytic and postdialytic rebound kinetics of plasma phosphorus during conventional and short 2-hour HD treatments. In this model, individual patient differences in phosphorus kinetics were characterized by a single parameter, the phosphorus mobilization clearance (K(M)). In this report we determined K(M) in patients treated by in-center nocturnal HD (ICNHD) and short daily HD (SDHD) with low dialyzer phosphate clearance. In the ICNHD study, eight patients underwent 8-hour HD treatments where intradialytic and postdialytic plasma samples were collected; K(M) values were determined by nonlinear regression of plasma concentration as a function of time. In the SDHD study, five patients were studied during 28 treatments for approximately 3 hours. Here, K(M) was calculated using only predialytic and postdialytic plasma phosphorus concentrations. Dialyzer phosphate clearances were 134 ± 20 (mean ± SD) and 95 ± 16 mL/min during ICNHD and SDHD, respectively. K(M) values for the respective therapies were 124 ± 83 and 103 ± 33 mL/min, comparable to those determined previously during conventional and short HD treatments of 98 ± 44  mL/min. When results from ICNHD, SDHD, and previous HD modalities were combined, K(M) was directly correlated with postdialytic body weight (r = 0.38, P = 0.025) and inversely correlated with predialytic phosphorus concentration (r = -0.47, P = 0.005). These findings suggest that phosphorus kinetics during various HD modalities can be described by a pseudo one-compartment model.
authors.affiliation: Medical Products R&D (Renal), Baxter Healthcare Corporation, McGaw Park, Illinois 60085, USA.
authors.forename: Baris U
authors.initials: BU
authors.lastname: Agar
authors.forename: Laura
authors.initials: L
authors.lastname: Troidle
authors.forename: Frederic O
authors.initials: FO
authors.lastname: Finkelstein
authors.forename: Orly F
authors.initials: OF
authors.lastname: Kohn
authors.forename: Alp
authors.initials: A
authors.lastname: Akonur
authors.forename: John K
authors.initials: JK
authors.lastname: Leypoldt
mesh_terms: D005260:Female; D006437:Hemodialysis, Home / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D010758:Phosphorus / Q000097:blood*; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D010710:Phosphates; D010758:Phosphorus