title: Comparative performance of macrocyclic lactones against large strongyles in horses.
abstract: Several formulations of macrocyclic lactones (abamectin, ivermectin, moxidectin), including ivermectin combined with pyrantel (tetrahydropyrimidine) and ivermectin combined with praziquantel (pyrazinoisoquinolin derivative), were tested regarding their efficacy to control gastrointestinal nematodes of horses on a stud farm in southern Brazil. In addition, we tested a pharmaceutically produced generic paste containing ivermectin 4%. Similar formulations of avermectins had different efficacies measured by reduction of EPG. Levels of efficacy of the tested drugs varied against Strongylus edentatus, S. equinus and S. vulgaris. The generic paste (ivermectin 4%) was less effective than the conventional drugs.
authors.affiliation: Depto. de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Prédio 44, 97105-900, Santa Maria, RS, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Toscan
authors.forename: A S
authors.initials: AS
authors.lastname: Cezar
authors.forename: R C F
authors.initials: RC
authors.lastname: Pereira
authors.forename: G B
authors.initials: GB
authors.lastname: Silva
authors.forename: L A
authors.initials: LA
authors.lastname: Sangioni
authors.forename: L S S
authors.initials: LS
authors.lastname: Oliveira
authors.forename: F S F
authors.initials: FS
authors.lastname: Vogel
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D006734:Horse Diseases / Q000188:drug therapy / Q000469:parasitology*; D006736:Horses; D010270:Parasite Egg Count; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000871:Anthelmintics