title: Curcumin inhibits inflammatory response and bone loss during experimental periodontitis in rats.
abstract: OBJECTIVE
  Curcumin, an active ingredient of turmeric, is proved to be a potential candidate of controlling inflammation and bone resorption, but few reports are on the periodontitis. The purpose of this study was to evaluate whether the intra-gastric administration of curcumin could inhibit the inﬂammation and alveolar bone resorption in rats following ligature-induced experimental periodontitis.
  
  
  METHODS
  Male Wistar rats were randomly divided into three groups: no ligature placement and administration of vehicle, ligature placement and administration of vehicle, ligature placement and administration of curcumin. After the animals were sacrificed, their mandibles were collected for morphological, histological and immunohistochemical analysis; their gingival tissues were collected for cytokine measurements.
  
  
  RESULTS
  Bone resorption was significantly higher in the experimental periodontitis animals treated with vehicle compared with the curcumin-treated group or the control group. Furthermore, receptor activator of nuclear factor-κB ligand (RANKL), receptor activator of nuclear factor-κB (RANK), osteoprotegerin (OPG), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expression levels were higher in the experimental periodontitis animals treated with vehicle compared with the curcumin treated group or the control group. CONCLUSIONS. Curcumin may decrease alveolar bone loss in the experimental periodontitis rats via suppressing the expression of RANKL/RANK/OPG and its anti-inflammatory properties.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, PR China.
authors.forename: Te
authors.initials: T
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Xiaoju
authors.initials: X
authors.lastname: Sun
authors.forename: Yaling
authors.initials: Y
authors.lastname: Song
authors.forename: Changning
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000378:metabolism / Q000517:prevention & control*; D010518:Periodontitis / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018836:Inflammation Mediators; D003474:Curcumin