title: An overview of esophageal squamous cell carcinoma proteomics.
abstract: Esophageal squamous cell carcinoma (ESCC) still remains the leading cancer-caused mortality in northern China, in particular in areas nearby Taihang Mountain. Late-stage diagnosis of ESCC increases the mortality and morbidity of ESCC. Therefore, it is imperative to identify biomarkers for early diagnosis, monitoring of tumor progression and identifying potential therapeutic targets of ESCC. Proteomics provides a functional translation of the genome and represents a richer source for the functional description of diseases and biomarkers implicated in cancer. In this review, we discuss the dysregulated proteins associated with ESCC identified by proteomic approaches and aim to enhance our understanding of molecular mechanisms implicated in ESCC development and progression from a proteomics perspective and discuss the potential biomarkers of ESCC as well.
authors.affiliation: Key Laboratory of Cellular and Molecular Immunology, Institute of Immunology, Medical School of Henan University, Kaifeng, Henan, P. R. China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Qi
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Chao
authors.forename: Jen-Fu
authors.initials: JF
authors.lastname: Chiu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D013785:Thailand / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020543:Proteome