title: Physiologically based structure of mean residence time.
abstract: A mean residence time (MRT) is an important pharmacokinetic parameter. To the author's knowledge, however, a physiologically based structure of MRT (thereafter MRT structure) has not been published so far. Primarily this is because MRT structures cannot be identified by traditional pharmacokinetic methods used for the determination of MRT. Therefore, tools from the theory of linear dynamic systems were used for the structural identification of MRT in this study. The MRT structure identified is physiologically meaningful. Accordingly, it seems that the MRT structure identified may contribute to already established knowledge about MRT.
authors.affiliation: The Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia. maria.durisova@savba.sk
authors.forename: Mária
authors.initials: M
authors.lastname: Durišová
mesh_terms: D001776:Blood Circulation Time / Q000379:methods*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000097:blood; D010599:Pharmacokinetics; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations