title: [Liver detoxifying function disorders in children with chronic hepatic disease and their correction].
abstract: In the present study liver detoxifying function state in children with chronic hepatitis and pigmentary hepatosis was examined. An endogenous intoxication level increase, peroxide processes and biotransformation system activation were established against the background of endotoxicosis substrate accumulation in blood. The dynamics of clinical symptoms and liver detoxifying function indicators was estimated against the background of the complex treatment with Reamberin. In our study we have noticed detoxication mechanisms improvement, and that fact has been confirmed by a decrease of endogenous intoxication level and significant middle-mass molecules decreasing in blood plasma as well as intoxication index and glutathione enzymes activity in blood.
authors.forename: S V
authors.initials: SV
authors.lastname: Romanova
authors.forename: T A
authors.initials: TA
authors.lastname: Vidmanova
authors.forename: E A
authors.initials: EA
authors.lastname: Zhukova
authors.forename: L V
authors.initials: LV
authors.lastname: Korkotashvili
authors.forename: A B
authors.initials: AB
authors.lastname: Iazykova
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D050217:Metabolic Detoxication, Phase II; D013386:Succinates / Q000008:administration & dosage*
chemical_list: C549374:Reamberin; D013386:Succinates; D008315:Malondialdehyde; D008536:Meglumine; D005980:Glutathione Reductase; D005982:Glutathione Transferase