title: An exception within the group of autoimmune blistering diseases: dermatitis herpetiformis, the gluten-sensitive dermopathy.
abstract: Dermatitis herpetiformis (DH) is characterized by chronic, itching papules, seropapules, small vesicles and, exceptionally, large blisters. The distribution of these polymorphic symptoms around the elbow, knee, buttock, and back is suggestive of the diagnosis. DH is further confirmed by the accumulation of granulocytes at the papillary dermis, resulting in a subepidermal split formation and by the presence of a unique, granular IgA precipitate in the uppermost dermis. Prognosis is predominantly determined by other autoimmune pathologies, malabsorption, or very rarely by lymphomas. Some of these diseases can be prevented by an early-onset, strict gluten-free diet, which is therefore the suggested treatment option.
authors.affiliation: Department of Dermatology, Venereology and Dermato-Oncology, Semmelweis University, Mária utca 41, Budapest 1085, Hungary. skarpati@t-online.hu
authors.forename: Sarolta
authors.initials: S
authors.lastname: Kárpáti
mesh_terms: D001259:Ataxia / Q000175:diagnosis; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D002446:Celiac Disease / Q000175:diagnosis / Q000473:pathology; D003874:Dermatitis Herpetiformis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D055050:Diet, Gluten-Free; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000473:pathology; D011110:Polymorphism, Genetic; D012867:Skin / Q000276:immunology* / Q000473:pathology; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D006683:HLA-DQ Antigens; C498712:TGM3 protein, human; D011503:Transglutaminases