title: Sole abnormalities of chromosome 7 in myeloid malignancies: spectrum, histopathologic correlates, and prognostic implications.
abstract: Among 6,565 consecutive abnormal cytogenetic reports at our institution, 3,192 (49%) constituted sole abnormalities, of which 230 (7%) involved chromosome 7: monosomy 7 (n = 98), 7q- (n = 51), der(1;7)(q10;p10) (n = 44), balanced translocations (n = 15), ring 7 (n = 13), and 7p- (n = 9). The most frequent histopathologic correlates were myelodysplastic syndromes (MDS; 28%), acute myeloid leukemia (AML; 17%), secondary or therapy-related MDS/AML (13%), primary myelofibrosis (PMF; 7%), and chronic myelomonocytic leukemia (6%). Monosomy 7 was the most frequent in each one of these disease categories except PMF where 7q- was more frequent. In primary MDS, patients with der(1;7)(q10;p10) (n = 13), compared to those with monosomy 7 (n = 30) or 7q- (n = 15), were less likely (P = 0.04) to display excess blasts or multilineage dysplasia but overall and leukemia-free survival adjusted for these variables revealed no significant difference between the three groups (P = 0.57 and 0.81, respectively). The current study does not prognostically distinguish monosomy 7 from 7q- or der(1;7), in MDS.
authors.affiliation: Mayo Medical School, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Fareeda Taher Nazer
authors.initials: FT
authors.lastname: Hussain
authors.forename: Edward P
authors.initials: EP
authors.lastname: Nguyen
authors.forename: Sania
authors.initials: S
authors.lastname: Raza
authors.forename: Ryan
authors.initials: R
authors.lastname: Knudson
authors.forename: Animesh
authors.initials: A
authors.lastname: Pardanani
authors.forename: Curtis A
authors.initials: CA
authors.lastname: Hanson
authors.forename: Daniel
authors.initials: D
authors.lastname: Van Dyke
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000139:chemically induced / Q000235:genetics*; D055728:Primary Myelofibrosis / Q000235:genetics; D012303:Ring Chromosomes; D016019:Survival Analysis; D014178:Translocation, Genetic; D014481:United States; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents