title: Silent cerebrovascular damage and its early correlates in essential hypertensive patients.
abstract: This study tested the association between cognitive functions, cerebrovascular damage, and cerebrovascular reactivity in 71 essential young hypertensives (age matched) and 22 normotensives (age matched). They underwent ambulatory blood pressure monitoring, neurocognitive tests, cerebral magnetic resonance, and transcranial Doppler. Twenty-three percent of patients showed more than 10 white matter lesions and 8% showed none. No control subjects showed more than 10 white matter lesions and 90% of normal controls showed no lesions. Patients with more than 10 white matter alterations had longer hypertensive story and showed significant lower nocturnal blood pressure fall. Pulsatility index was correlated with the number of white matter lesions.
authors.affiliation: Hypertension Unit, AOU S. Giovanni Battista, University of Turin, Turin, Italy. cristina.paglieri@libero.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Paglieri
authors.forename: Franco
authors.initials: F
authors.lastname: Rabbia
authors.forename: Mauro
authors.initials: M
authors.lastname: Bergui
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Genesia
authors.forename: Antonella
authors.initials: A
authors.lastname: Canadè
authors.forename: Elena
authors.initials: E
authors.lastname: Berra
authors.forename: Chiara
authors.initials: C
authors.lastname: Fulcheri
authors.forename: Michele
authors.initials: M
authors.lastname: Covella
authors.forename: Cristina
authors.initials: C
authors.lastname: Di Stefano
authors.forename: Paolo
authors.initials: P
authors.lastname: Cerrato
authors.forename: Franco
authors.initials: F
authors.lastname: Veglio
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D002561:Cerebrovascular Disorders / Q000150:complications*; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests