title: Two new aryltetralin lignans from the roots of Dolomiaea souliei.
abstract: Two new aryltetralin-type lignans, dolomiaeasin A (1) and dolomiaeasin B (2), were isolated from the roots of Dolomiaea souliei. Their structures were elucidated by means of various spectroscopic analyses. The cytotoxicities of 1 and 2 were tested by the MTT method, and both compounds showed no significant cytotoxic activities against the A549 and A2780 human cancer cell lines. This is the first time that aryltetralin-type lignans were isolated from the genus Dolomiaea.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Chunnian
authors.initials: C
authors.lastname: He
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Chen
authors.forename: Peigen
authors.initials: P
authors.lastname: Xiao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts; C574346:dolomiaeasin A; C574347:dolomiaeasin B