title: [Synaptic vesicle recycling and Alzheimer's disease].
abstract: Loss of synapses correlates well with cognitive decline in Alzheimer's disease (AD). However, the molecular mechanisms underlying the synaptic dysfunction and loss are not well understood. Synaptic vesicle (SV) recycling is a key process for synaptic transmission. A body of evidences suggested that malfunction or loss of the machinery for SV recycling occurred in AD, which could result in disruption of neuronal circuitry. In this article, we summarized the recent progress in the research of synaptic proteins for SV recycling and the pathological changes of some proteins in AD.
authors.affiliation: Research Library of Cell Regulation of Cell Regulation, Shanghai Jiaotong University Medical School, Shanghai 200025, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Xia
authors.forename: Ya-Er
authors.initials: YE
authors.lastname: Hu
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D013569:Synapses / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism / Q000502:physiology*; D016708:Synaptophysin / Q000502:physiology; D050857:Synaptotagmins / Q000502:physiology
chemical_list: D015220:Calcium Channels; D016708:Synaptophysin; D050857:Synaptotagmins