title: Percutaneously placed central venous catheter-related sepsis in Canadian neonatal intensive care units.
abstract: OBJECTIVE
  To estimate daily risk, variability between centers, and impact on outcomes of catheter-related sepsis (CRS) among preterm neonates.
  
  
  METHODS
  Retrospective evaluation of data from centers in the Canadian Neonatal Network for neonates born at <29 weeks or <1000 g who had a percutaneously placed central venous catheter (PCVC) in place for ≥ 48 hours.
  
  
  RESULTS
  Of 2966 infants with a PCVC, 582 (19.6%) developed CRS (overall rate 11/1000 catheter days). The daily risk of CRS varied between 1% and 2% in the first 28 days, and rates of CRS varied between centers (0 to 37 infections/1000 catheter days). Birth weight and gestational age were lower, and Score for Neonatal Acute Physiology and day of life of insertion were higher among those with CRS. Average length of stay was 6.2 days longer for those with CRS. There was no difference in mortality or major morbidities between infants who had CRS and those without CRS.
  
  
  CONCLUSIONS
  No threshold length of catheter usage days within the first 28 days was identified at or after which the risk of CRS increased. Marked variability between centers was present. Patients with CRS had an increased length of stay, but no increased risk for mortality or major morbidities.
authors.affiliation: Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, Canada.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wong
authors.forename: Kimberly
authors.initials: K
authors.lastname: Dow
authors.forename: Prakesh S
authors.initials: PS
authors.lastname: Shah
authors.forename: Wayne
authors.initials: W
authors.lastname: Andrews
authors.forename: Shoo
authors.initials: S
authors.lastname: Lee
mesh_terms: D002170:Canada; D062905:Central Venous Catheters / Q000009:adverse effects*; D003428:Cross Infection / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D007363:Intensive Care Units, Neonatal; D007902:Length of Stay; D008297:Male; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology