title: Pancreatic cancer: surgical management and outcomes after 6 years of follow-up.
abstract: OBJECTIVE
  To describe the management and outcomes of a population-based cohort of patients with pancreatic cancer in Victoria, Australia.
  
  
  METHODS
  Retrospective study based on questionnaires completed from medical histories of patients diagnosed with pancreatic cancer during 2002-2003 in Victoria who were identified from the Victorian Cancer Registry and followed up for 6 years.
  
  
  METHODS
  Proportion of patients receiving each form of treatment, 30-day mortality, median survival, and 5-year and 6-year survival.
  
  
  RESULTS
  Of 1044 patients with pancreatic cancer identified, 927 were eligible for the study, and questionnaires were completed for 830 (response rate, 89.5%); 67 patients with ampulla of Vater and neuroendocrine tumours were excluded. Of the 763 remaining patients (median age, 72 years), notification of death was available for 747 (97.9%). Most patients (n = 548) had tumours in the head and neck of the pancreas. Resection was performed in a total of 87 patients (11.4%). Patients managed with Whipple resection (n = 75) had a 30-day mortality rate of 5.3% and median survival of 16.3 months. A relatively large number of surgeons (n = 31) each performed a modest number of Whipple resections during the study period. Jaundice was palliated with biliary stents (n = 240) and bypass surgery (n = 99). Survival was shortest in those treated with best supportive care (median, 2.3 months for those with head and neck of pancreas tumours, and 3.4 months for body and tail of pancreas tumours). Of the 20 patients who survived to 5 years, 10 did not have histological confirmation of carcinoma and were presumably false-positive diagnoses, and three of the 10 patients who did have positive histological results had experienced recurrent disease by 6-year follow-up.
  
  
  CONCLUSIONS
  Most outcomes in Victoria compared favourably with other studies. Prognosis for patients with carcinoma of the pancreas is grim, with few long-term survivors. Six-year survival appears to be a better proxy for cure than 5-year survival.
authors.affiliation: Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, VIC, Australia. tony.speer@mh.org.au
authors.forename: Antony G
authors.initials: AG
authors.lastname: Speer
authors.forename: Vicky J
authors.initials: VJ
authors.lastname: Thursfield
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Torn-Broers
authors.forename: Michael
authors.initials: M
authors.lastname: Jefford
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001662:Biliary Tract Surgical Procedures / Q000295:instrumentation / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D012042:Registries; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D015996:Survival Rate; D016896:Treatment Outcome