title: Racial difference in aldose reductase C-106T genetic polymorphism and association with essential hypertension.
abstract: OBJECTIVE
  To investigate the distribution of aldose reductase (AR) C-106T genetic polymorphism in Chinese Han population and its association with the risk for essential hypertension (EH).
  
  
  METHODS
  The AR C-106T polymorphism was genotyped in 148 Chinese EH patients and 137 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype distribution between groups was contrasted by Χ(2)- test and the degree of genetic association was evaluated by 95% confidence interval (CI).
  
  
  RESULTS
  Frequency of the variant AR C-106T allele was 13.9% (95% CI: 11.2%-16.6%) in the controls, which was significantly lower than that in the Japanese (18.4% in 712 individuals, P=0.0063), the Australians (37.9% in 240 individuals, P<0.0001) and the Brazilians (34.7% in 62 individuals, P<0.0001). The frequency of AR C-106T allele was 11.7% (95% CI: 7.9%-15.5%) in the EH patients. No significant difference in the allele frequency was observed between the EH patients and the controls (P=0.147).
  
  
  CONCLUSIONS
  There is obvious racial difference in the distribution of AR C-106T polymorphism. The polymorphism is not associated with the risk for EH.
authors.affiliation: Institute of Clinical Pharmacology, Central South University, Changsha, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Li
authors.forename: Huanlian
authors.initials: H
authors.lastname: Cheng
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
authors.forename: Kai
authors.initials: K
authors.lastname: Hu
authors.forename: Junjie
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Deng
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Ouyang
mesh_terms: D000328:Adult; D000449:Aldehyde Reductase / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D000449:Aldehyde Reductase