title: The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.
abstract: Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer.
authors.affiliation: Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance, Seattle, WA, USA. rgmart@u.washington.edu
authors.forename: Renato G
authors.initials: RG
authors.lastname: Martins
authors.forename: Thomas A
authors.initials: TA
authors.lastname: D'Amico
authors.forename: Billy W
authors.initials: BW
authors.lastname: Loo
authors.forename: Mary
authors.initials: M
authors.lastname: Pinder-Schenck
authors.forename: Hossein
authors.initials: H
authors.lastname: Borghaei
authors.forename: Jamie E
authors.initials: JE
authors.lastname: Chaft
authors.forename: Apar Kishor P
authors.initials: AK
authors.lastname: Ganti
authors.forename: Feng-Ming Spring
authors.initials: FM
authors.lastname: Kong
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kris
authors.forename: Inga T
authors.initials: IT
authors.lastname: Lennes
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Wood
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods; D002986:Clinical Trials as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008482:Mediastinum / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome