title: Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats.
abstract: Exercise training normalizes sympathetic outflow in hypertension and chronic heart failure. The aim of this study was to determine whether the exercise training inhibits sympathetic nerve activity (SNA) via reduction of oxidative stress through blocked angiotensin II type 1 receptor (AT(1)R) in rostral ventrolateral medulla (RVLM). We divided stroke-prone spontaneously hypertensive rats (SHRSP) into SHRSP with exercised training (SHRSP-EX) and control (SHRSP-C). SNA and oxidative stress in the RVLM were significantly lower in SHRSP-EX than in SHRSP-C. These results suggest that exercise training inhibits SNA via reduction of oxidative stress through blocked AT(1)R in the RVLM of hypertension.
authors.affiliation: Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. tkishi@cardiol.med.kyushu-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Kishi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Masato
authors.initials: M
authors.lastname: Katsuki
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Ogawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shinohara
authors.forename: Kengo
authors.initials: K
authors.lastname: Isegawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure; D003497:Cyclic N-Oxides / Q000008:administration & dosage; D006339:Heart Rate; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000503:physiopathology; D009638:Norepinephrine / Q000652:urine; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D013113:Spin Labels; D013564:Sympathetic Nervous System / Q000503:physiopathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D003497:Cyclic N-Oxides; D044140:Receptor, Angiotensin, Type 1; D013113:Spin Labels; D017392:Thiobarbituric Acid Reactive Substances; D000804:Angiotensin II; C001803:tempol; D009638:Norepinephrine