title: Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
abstract: Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Gizem
authors.initials: G
authors.lastname: Rizki
authors.forename: Colette Lafontaine
authors.initials: CL
authors.lastname: Picard
authors.forename: Charles
authors.initials: C
authors.lastname: Pereyra
authors.forename: Siu Sylvia
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D017238:Genes, Helminth; D051863:Host Cell Factor C1 / Q000235:genetics / Q000378:metabolism*; D008136:Longevity / Q000235:genetics / Q000502:physiology; D009154:Mutation; D018384:Oxidative Stress; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D051863:Host Cell Factor C1; D014157:Transcription Factors; C497691:hcf-1 protein, C elegans; C073702:skn-1 protein, C elegans