title: Elevation of sE-Selectin Levels 2-24 Months following Gestational Diabetes Is Associated with Early Cardiometabolic Risk in Nondiabetic Women.
abstract: Objective. We hypothesised that the endothelial dysfunction is associated with early glucose dysregulation and/or atherosclerosis risk factors in nondiabetic women with a previous history of gestational diabetes (pGDM). Material/Methods. Anthropometric parameters, glucose regulation (OGTT), insulin resistance (HOMA), lipids, biomarkers of endothelial dysfunction, and inflammation were evaluated in 85 women with pGDM and in 40 controls 2-24 months postpartum. Results. The pGDM group consisted of 67% normoglycemic women (pGDM-N) and 33% with prediabetic state (pGDM-P). The BMI, waist circumference, fasting and 2 h glucose (OGTT), soluble adhesion molecules, tissue plasminogen activator antigen, high sensitivity C-reactive protein, total-, LDL-cholesterol, and triglycerides/HDL-cholesterol ratio were higher in the pGDM women compared with the controls. After adjustment for BMI and fasting glucose, only higher triglycerides, higher TG/HDL and lower HDL-cholesterol were associated with pGDM. The pGDM-P differed from pGDM-N for only higher triglycerides and TG/HDL. The plasma level of sE-selectin was not independently associated with glucose concentration in pGDM group. sE-selectin level correlated with triglycerides, TG/HDL, plasminogen activator inhibitor-1 antigen, and sICAM-1. Conclusions. sE-selectin level correlated with components of metabolic syndrome, but only the atherogenic lipid profile was independently associated with a previous history of GDM in nondiabetic women 2-24 months postpartum.
authors.affiliation: Department of Gastroenterology, Angiology and Internal Diseases, Nicolaus Copernicus University, Dr J. Biziel University Hospital, Bydgoszcz, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Sokup
authors.forename: Barbara
authors.initials: B
authors.lastname: Ruszkowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Góralczyk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Góralczyk
authors.forename: Marek
authors.initials: M
authors.lastname: Szymański
authors.forename: Marek
authors.initials: M
authors.lastname: Grabiec
authors.forename: Danuta
authors.initials: D
authors.lastname: Rość