title: Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.
abstract: Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectroscopic (for both) and single-crystal X-ray diffraction (for 1) analysis. All compounds isolated were evaluated for their potential as immunosuppressive agents and the data suggested that Gelsemium alkaloids of different structural types possibly have potential as immunosuppressive agents.
authors.affiliation: CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan Province, PR China. xyk@xtbg.ac.cn
authors.forename: You-Kai
authors.initials: YK
authors.lastname: Xu
authors.forename: Shang-Gao
authors.initials: SG
authors.lastname: Liao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Na
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Hu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
mesh_terms: D000818:Animals; D031450:Gelsemium / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: C576442:11-methoxygelselegine; C576443:21-(2-oxopropyl)-koumine; D007166:Immunosuppressive Agents; D026121:Indole Alkaloids; D010936:Plant Extracts; C515085:koumine