title: Skin prick testing in atopic eczema: atopic to what and at what age?
abstract: BACKGROUND
  Atopic eczema is a common and distressing disease. This study aimed to review the age-dependent pattern of atopic sensitization to food and aeroallergens in patients with eczema by skin prick testing.
  
  
  METHODS
  The results of skin prick test (SPT), serum IgE, bronchial challenge test, and family history of atopy in eczema patients seen at a pediatric dermatology clinic were reviewed.
  
  
  RESULTS
  SPT results were available in 816 eczema patients. In these patients, 90% had atopic sensitization to at least one aeroallergen, 69% to at least one food allergen, and 94% to at least one allergen by SPT. Together with a family history of atopy in parents or siblings and a personal history of airway atopies, 97% and 99.8% of the patients were atopic, respectively. Bronchial hyper-reactivity (BHR) was demonstrated in 44% of 339 patients. Aeroallergen was more prevalent than food allergen sensitization among children older than 10 years. The mites (D. pteronysissnus, D. farinae and Blomia Tropicalis) were the most prevalent allergens regardless of age and BHR, but D. pteronysissnus and D. farinae sensitization were more prevalent among BHR-positive patients. Beef is the least sensitized food protein in all ages.
  
  
  CONCLUSIONS
  The majority of patients with eczema are atopic to aeroallergens. The mites (D. pteronysissnus, D. farinae and Blomia Tropicalis) are the most prevalent allergens regardless of age and BHR.
authors.affiliation: Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. ehon@hotmail.com
authors.forename: Kam Lun
authors.initials: KL
authors.lastname: Hon
authors.forename: Shuxin Susan
authors.initials: SS
authors.lastname: Wang
authors.forename: Wing Lam
authors.initials: WL
authors.lastname: Wong
authors.forename: Wing Kwan
authors.initials: WK
authors.lastname: Poon
authors.forename: Ka Yi
authors.initials: KY
authors.lastname: Mak
authors.forename: Ting Fan
authors.initials: TF
authors.lastname: Leung
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D002648:Child; D003876:Dermatitis, Atopic / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D008297:Male; D012882:Skin Tests
chemical_list: D000485:Allergens