title: Effect of nimbidin on gastric Acid secretion.
abstract: Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 - receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.
authors.affiliation: C. D. R. S. Pharmacological Unit, Dept. of Pharmacology Medical College, Trivandrum - 695 011, India.
authors.forename: N R
authors.initials: NR
authors.lastname: Pillai
authors.forename: G
authors.initials: G
authors.lastname: Santhakumari