title: [Prohibited substances in cosmetics: prospect of the toxicity of acrylamide].
abstract: Prohibited substances in cosmetics refer to substances which must not be among the raw material ingredients of cosmetic products. These substances are absorbed mostly through skin, as well as via lung and gastrointestinal tract. Polyacrylamide is ubiquitously used in industry and its decomposition residue acrylamide (ACR) easily finds its way into cosmetic products. ACR can either be oxidized to epoxide glycidamide or conjugated with glutathione, hemoglobin or DNA; ultimately it is excreted in urine. ACR causes neurotoxicity, reproductive toxicity and tumors in rodents. Occupational exposure to ACR causes neurotoxicity in humans; however, epidemiological evidence have not unambiguously answered the question of whether ACR exposure can increase cancer risk for humans.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410008, China.
authors.forename: Minxue
authors.initials: M
authors.lastname: Shen
authors.forename: Zhenqiu
authors.initials: Z
authors.lastname: Sun
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Shi
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Hu
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D020106:Acrylamide / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D000180:Acrylic Resins / Q000737:chemistry; D002681:China; D003358:Cosmetics / Q000737:chemistry*; D006801:Humans; D000099166:Polyacrylamides
chemical_list: D020106:Acrylamide; D000180:Acrylic Resins; D003358:Cosmetics; D000099166:Polyacrylamides