title: A clinical approach to early-onset inheritable dementia.
abstract: Early-onset dementia, presenting before age 65 years, is increasingly recognized. It is often difficult to diagnose, since non-Alzheimer's etiologies and unusual dementias are common. These conditions are more commonly genetic, and important potentially inherited causes of early-onset dementia include early-onset Alzheimer's disease, frontotemporal dementia, Kufs' disease, and Niemann-Pick disease type C. For each of these diseases, this review provides information on common clinical presentations, etiology, pathophysiology, and current and experimental treatments. A discussion of the diagnosis and workup for early-onset dementia is included with an emphasis on conditions that may have other involved family members.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Rogers
authors.forename: Carol F
authors.initials: CF
authors.lastname: Lippa
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D004198:Disease Susceptibility; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D009472:Neuronal Ceroid-Lipofuscinoses / Q000175:diagnosis / Q000453:epidemiology; D052556:Niemann-Pick Disease, Type C / Q000175:diagnosis / Q000453:epidemiology