title: Comparison of phase-contrast MR imaging and endovascular sonography for intracranial blood flow velocity measurements.
abstract: OBJECTIVE
  Local hemodynamic information may help to stratify rupture risk of cerebral aneurysms. Patient-specific modeling of cerebral hemodynamics requires accurate data on BFV in perianeurysmal arteries as boundary conditions for CFD. The aim was to compare the BFV measured with PC-MR imaging with that obtained by using intra-arterial Doppler sonography and to determine interpatient variation in intracranial BFV.
  
  
  METHODS
  In 10 patients with unruptured intracranial aneurysms, BFV was measured in the cavernous ICA with PC-MR imaging in conscious patients before treatment, and measured by using an intra-arterial Doppler sonography wire when the patient was anesthetized with either propofol (6 patients) or sevoflurane (4 patients).
  
  
  RESULTS
  Both techniques identified a pulsatile blood flow pattern in cerebral arteries. PSV differed >50 cm/s between patients. A mean velocity of 41.3 cm/s (95% CI, 39.3-43.3) was measured with PC-MR imaging. With intra-arterial Doppler sonography, a mean velocity of 29.3 cm/s (95% CI, 25.8-32.8) was measured with the patient under propofol-based intravenous anesthesia. In patients under sevoflurane-based inhaled anesthesia, a mean velocity of 44.9 cm/s (95% CI, 40.6-49.3) was measured.
  
  
  CONCLUSIONS
  We showed large differences in BFV between patients, emphasizing the importance of using patient-specific hemodynamic boundary conditions in CFD. PC-MR imaging measurements of BFV in conscious patients were comparable with those obtained with the intra-arterial Doppler sonography when the patient was anesthetized with a sevoflurane-based inhaled anesthetic.
authors.affiliation: Department of Radiology, Academic Medical Center, University of Amsterdam, the Netherlands. j.j.schneiders@amc.uva.nl
authors.forename: J J
authors.initials: JJ
authors.lastname: Schneiders
authors.forename: S P
authors.initials: SP
authors.lastname: Ferns
authors.forename: P
authors.initials: P
authors.lastname: van Ooij
authors.forename: M
authors.initials: M
authors.lastname: Siebes
authors.forename: A J
authors.initials: AJ
authors.lastname: Nederveen
authors.forename: R
authors.initials: R
authors.lastname: van den Berg
authors.forename: J
authors.initials: J
authors.lastname: van Lieshout
authors.forename: G
authors.initials: G
authors.lastname: Jansen
authors.forename: E
authors.initials: E
authors.lastname: vanBavel
authors.forename: C B
authors.initials: CB
authors.lastname: Majoie
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods*