title: Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma.
abstract: Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.
authors.affiliation: Department of Chemotherapy, Shandong University, Jinan, Shandong, People's Republic of China.
authors.forename: Ji-Sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Ying
authors.forename: Xiu-Wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Tao
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D018899:CpG Islands / Q000235:genetics; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism; D000077277:Esophageal Squamous Cell Carcinoma; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D006801:Humans; D011401:Promoter Regions, Genetic
chemical_list: D014408:Biomarkers, Tumor; D004248:DNA (Cytosine-5-)-Methyltransferases