title: Haematological alterations in Rattus norvegicus (Wistar) experimentally infected with Echinostoma paraensei (Trematoda: Echinostomatidae).
abstract: Laboratory rats (Rattus norvegicus) were infected with Echinostoma paraensei (Trematoda: Echinostomatidae). The rodents received 150 metacercariae each and blood samples were collected weekly until the fifth week of infection. The blood samples were analyzed for determination of haematocrit, total red blood cells with their dimensions, haemoglobin and haematimetric index (mean corpuscular volume, MCV; mean corpuscular haemoglobin, MCH; and mean corpuscular haemoglobin concentration, MCHC) and platelets. Red blood cells, haematocrit and haemoglobin in the first week had significantly lower levels than those of uninfected (control) rats, suggesting the development of normocytic and normocromic anaemia with anisocytic alteration. The number of eosinophils did not increase significantly among the groups. We concluded that E. paraensei produces haematological alterations in R. norvegicus, causing regenerative anaemia. This system can therefore be a useful model to study the direct and indirect effects of gastrointestinal infections.
authors.affiliation: Curso de Pós-Graduação em Ciências Veterinárias, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil. juberlan@ioc.fiocruz.br
authors.forename: J S
authors.initials: JS
authors.lastname: Garcia
authors.forename: J
authors.initials: J
authors.lastname: Pinheiro
authors.forename: C S
authors.initials: CS
authors.lastname: Hooper
authors.forename: R O
authors.initials: RO
authors.lastname: Simões
authors.forename: J S
authors.initials: JS
authors.lastname: Ferraz
authors.forename: A
authors.initials: A
authors.lastname: Maldonado
mesh_terms: D000208:Acute Disease; D000740:Anemia / Q000097:blood / Q000209:etiology*; D000818:Animals; D004449:Echinostoma / Q000502:physiology*; D004451:Echinostomiasis / Q000097:blood* / Q000150:complications / Q000469:parasitology; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007411:Intestinal Diseases, Parasitic / Q000097:blood* / Q000150:complications / Q000469:parasitology; D007421:Intestine, Small / Q000469:parasitology; D007958:Leukocyte Count; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006454:Hemoglobins