title: NuRD and pluripotency: a complex balancing act.
abstract: Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.
authors.affiliation: Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. hug4@niehs.nih.gov
authors.forename: Guang
authors.initials: G
authors.lastname: Hu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Wade
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D053595:Embryonic Stem Cells / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex