title: How nascent phagosomes mature to become phagolysosomes.
abstract: Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its membrane and contents that culminates in the formation of phagolysosomes. Maturation entails orderly sequential fusion of the phagosomal vacuole with specialized endocytic and secretory compartments. Concomitantly, the phagosomal membrane undergoes both inward and outward vesiculation and tubulation followed by fission, thereby recycling components and maintaining its overall size. Here, we summarize what is known about the molecular machinery that governs this complex metamorphosis of phagosome maturation.
authors.affiliation: Program in Cell Biology, Hospital for Sick Children and Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Fairn
authors.forename: Sergio
authors.initials: S
authors.lastname: Grinstein
mesh_terms: D000818:Animals; D002118:Calcium / Q000276:immunology / Q000378:metabolism; D008247:Lysosomes / Q000276:immunology* / Q000378:metabolism; D010588:Phagosomes / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D020691:rab GTP-Binding Proteins / Q000276:immunology
chemical_list: D020691:rab GTP-Binding Proteins; D002118:Calcium