title: Comparison of optic nerve head topography and retinal nerve fiber layer in eyes with narrow angles versus eyes from a normal open angle cohort - a pilot study.
abstract: OBJECTIVE
  To compare the optic nerve head (ONH) and retinal nerve fiber layer (RNFL) in eyes with narrow angles and normal intraocular pressure (IOP) to normal control eyes.
  
  
  METHODS
  A total of 70 eyes of 52 subjects with narrow angles and 40 eyes of 34 normal subjects were enrolled. Narrow angle eyes were defined as the following: (i) the pigmented trabecular meshwork was not visible for ≥ 180° on gonioscopy, (ii) untreated IOP ≤ 21 mmHg, (iii) no peripheral anterior synechiae (PAS) was observed, and (iv) optic discs were without glaucomatous changes, defined as neuroretinal rim thinning, focal notching, disc hemorrhages, or focal RNFL defects. ONH and peripapillary RNFL imaging were obtained with Heidelberg Retina Tomograph (HRT II) and Fourier-domain optical coherence tomography (RTVue OCT).
  
  
  RESULTS
  No significant difference was found in mean age between the two groups (p = 0.06), but the narrow angle group had significantly more women (p = 0.04). The narrow angle group had significantly higher IOP and smaller mean angle width (both p < 0.001). Vertical cup-to-disc ratio (VCDR) was significantly larger in the narrow angle group (p = 0.02). In visual field (VF) results, the mean deviation (MD) was significantly lower and pattern standard deviation (PSD) was significantly higher in the narrow angle group (both p < 0.001). After adjusting for disc area, the RNFL thickness of the inferior-temporal region was significantly thinner in the narrow angle group (135 ± 21.7 µm) compared with normal group (149 ± 22.1 µm, p < 0.01). This finding remained significant after Bonferroni correction for multiple comparisons. Smaller angle width was a significant predictor of RNFL thinning in the inferior-temporal region (p < 0.001).
  
  
  CONCLUSIONS
  These data suggest that eyes with narrow angles may develop glaucomatous optic nerve damage in the absence of IOP elevation during office hours.
authors.affiliation: Department of Ophthalmology, San Francisco School of Medicine, University of California, San Francisco ,  CA ,  USA.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Guofu
authors.initials: G
authors.lastname: Huang
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kasuga
authors.forename: Travis
authors.initials: T
authors.lastname: Porco
authors.forename: Por T
authors.initials: PT
authors.lastname: Hung
authors.forename: Roland
authors.initials: R
authors.lastname: Lee
authors.forename: Shan C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005583:Fourier Analysis; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000601:surgery; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000601:surgery; D053685:Laser Therapy; D053844:Lasers, Solid-State; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010865:Pilot Projects; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests