title: High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia.
abstract: OBJECTIVE
  The frequency of adult-type hypolactasia (lactase non-persistence) varies widely among different ethnic groups. The cultural historical hypothesis assumes a link between the occurrence of hypolactasia and the distribution of dairy farming. The nomadic Nenets have been reindeer herders for generations and have therefore not consumed any dairy products. The hypotheses here was that the prevalence of lactase non-persistence (-13910 C/C genotype) among Nenets people having four Nenets grandparents is high, while the prevalence among Nenets originating from ethnically mixed families is lower.
  
  
  METHODS
  The material was collected in four typical Nenets settlements in the Nenets Autonomous Okrug in Russia. One-third of the adult Nenets population were invited to answer a questionnaire and to donate buccal samples for genotyping by a doctor from the team of medical professionals who make rounds in this area. The total number of available participants was 177.
  
  
  METHODS
  Genotyping was performed with the AbiPrism system. We used the method of concordance of grandparents' national origin to ascribe ethnicity.
  
  
  RESULTS
  The prevalence of adult-type hypolactasia (-13910 C/C) among Nenets who had four Nenets grandparents was found to be 90%. The figures among others reporting three, two and one grandparent of Nenets origin were 72, 60 and 28%, respectively.
  
  
  CONCLUSIONS
  The findings are in accord with the cultural historical hypothesis.
authors.affiliation: Department of Family Medicine, Northern State Medical University, Arkhangelsk, Russia. YuliaKaterina@rambler.ru
authors.forename: Yulia
authors.initials: Y
authors.lastname: Khabarova
authors.forename: Valentina
authors.initials: V
authors.lastname: Grigoryeva
authors.forename: Sari
authors.initials: S
authors.lastname: Tuomisto
authors.forename: Pekka J
authors.initials: PJ
authors.lastname: Karhunen
authors.forename: Kari
authors.initials: K
authors.lastname: Mattila
authors.forename: Mauri
authors.initials: M
authors.lastname: Isokoski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D007787:Lactose Intolerance / Q000208:ethnology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D044382:Population Groups; D015995:Prevalence; D012426:Russia / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult