title: The relationship of carotid three-dimensional ultrasound vessel wall volume with age and sex: comparison to carotid intima-media thickness.
abstract: The relationship of three-dimensional ultrasound (3DUS)-derived carotid vessel wall volume (VWV) was evaluated with respect to age and sex. B-mode and 3DUS images were acquired for 316 subjects from diverse groups including obese primary prevention, diabetic nephropathy, renal transplant and rheumatoid arthritis populations. The relationship for intima-media thickness (IMT) and VWV with age and sex were determined using Pearson-product-moment correlations. Mean IMT (r = 0.18, p = 0.001) and VWV (r = 0.24, p < 0.01) correlated modestly with age. There were modest correlations in males (IMT, r = 0.19, p = 0.003; VWV, r = 0.34, p < 0.001) and in females for IMT and age (r = 0.30, p = 0.007) but not between 3DUS VWV and age in females (r = 0.10, p = 0.4). Significant associations between plaque and VWV (r = 0.36, p = 0.001) but not IMT suggest different correlations in females that may be attributed to plaque.
authors.affiliation: Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Buchanan
authors.forename: Tamas
authors.initials: T
authors.lastname: Lindenmaier
authors.forename: Shayna
authors.initials: S
authors.lastname: McKay
authors.forename: Yves
authors.initials: Y
authors.lastname: Bureau
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Hackam
authors.forename: Aaron
authors.initials: A
authors.lastname: Fenster
authors.forename: Grace
authors.initials: G
authors.lastname: Parraga
mesh_terms: D017677:Age Distribution; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D009929:Organ Size; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D014463:Ultrasonography / Q000706:statistics & numerical data*