title: A ceramide-centric view of insulin resistance.
abstract: The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of physiological processes and as a critical modulator of cellular stress. In this review, we discuss from a historical perspective the most important discoveries produced over the last decade supporting a role for ceramide and its metabolites in the pathogenesis of insulin resistance and other obesity-associated metabolic diseases. Moreover, we describe how a ceramide-centric view of insulin resistance might be reconciled in the context of other prominent models of nutrient-induced insulin resistance.
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27704, USA. jose.chavez@dm.duke.edu
authors.forename: Jose A
authors.initials: JA
authors.lastname: Chavez
authors.forename: Scott A
authors.initials: SA
authors.lastname: Summers
mesh_terms: D000818:Animals; D002518:Ceramides / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008659:Metabolic Diseases / Q000378:metabolism; D051379:Mice; D009765:Obesity / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D002518:Ceramides; D007328:Insulin; D013107:Sphingolipids