title: Clinical effects of topical pimecrolimus in a patient with Fox-Fordyce disease.
abstract: Fox-Fordyce disease (FFD) is characterized by a pruritic eruption of skin-coloured or yellowish papules in areas rich in apocrine glands. The histology comprises dilatation of follicular infundibula with hyperkeratosis, acanthosis, and spongiosis of the infundibular epithelium with perifollicular infiltration of lymphocytes and foamy histiocytes. We treated a 12-year-old girl with FFD with topical pimecrolimus for 12 weeks, this resulted in a complete clearance of lesions. After the therapy, the patient was followed for an additional 19 months without signs of relapse. The effects of pimecrolimus in FFD might imply that an inflammatory process inducing secondary reactive hyperkeratosis could be involved in the pathogenesis of FFD.
authors.affiliation: Institute of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Milcic
authors.forename: Milos
authors.initials: M
authors.lastname: Nikolic
mesh_terms: D002648:Child; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D005588:Fox-Fordyce Disease / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus