title: Association of -592 region of IL-10 polymorphisms with asthma in south-eastern Iranian patients.
abstract: BACKGROUND
  Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene.
  
  
  METHODS
  This study was carried out on 100 asthmatic patients and 100 healthy controls. PCR-RFLP was applied to examine the polymorphisms in the -592 region of the IL-10 gene.
  
  
  RESULTS
  Our results showed a significant difference between patients and controls in terms of genotypes and alleles of the -592 region of the IL-10 gene.
  
  
  CONCLUSIONS
  According to our results, it can be concluded that the IL-10 promoter polymorphisms may play a crucial role in the pathogenesis of asthma.
authors.affiliation: Physiology and Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Hakimizadeh
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Behzad Nasiri
authors.initials: BN
authors.lastname: Ahmadabadi
authors.forename: Hamid
authors.initials: H
authors.lastname: Hakimi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Rezaeian
authors.forename: Vajihe Akbarpour
authors.initials: VA
authors.lastname: Salehabadi
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefidaredor
authors.forename: Hamid
authors.initials: H
authors.lastname: Abousaidi
authors.forename: Derek
authors.initials: D
authors.lastname: Kennedy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D054458:Amplified Fragment Length Polymorphism Analysis; D001249:Asthma / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D016753:Interleukin-10; D007073:Immunoglobulin E