title: Gamma glutamyltransferase levels and its association with high sensitive C-reactive protein in patients with acute coronary syndromes.
abstract: BACKGROUND
  Elevated Gamma-glutamyltransferase (GGT) level is independently correlated with conditions associatedwith increased atherosclerosis, such as obesity, elevated serum cholesterol, high blood pressure and myocardial infarction. It is also demonstrated that serum gamma-glutamyltransferase activity is an independent risk factor for myocardial infarction and cardiac death in patients with coronary artery disease. Although the relationship between gamma-glutamyltransferase and coronary artery disease has been reported, not many studies have shown the relationship between changes ofgamma-glutamyltransferase in acute coronary syndromes and a well established coronary risk factor high sensitive C-reactive protein. (hs-CRP).
  
  
  OBJECTIVE
  In this study, how gamma-glutamyltransferase levels changed in acute coronary syndromes and its relationship with high sensitive C-reactive protein if any were studied.  PATIENTS #ENTITYSTARTX00026;
  
  
  METHODS
  This trial was carried out at Kosuyolu Cardiovascular Training and Research Hospital and Van Yuksek Ihtisas Hospital, Turkey. 219 patients (177 males and 42 females) presenting with acute coronary syndrome, and 51 control subjects between September 2007 and September 2008 were included in the study. Serum gamma-glutamyltransferase, high sensitive C-reactive protein, serum lipoprotein levels and troponin I were determined.
  
  
  RESULTS
  Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients compared to control. There was also correlation between gamma-glutamyltransferase and high sensitive C-reactive protein levels.
  
  
  CONCLUSIONS
  Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients. In subgroup analyses, the higher difference with Non-ST elevation myocardial infarction and ST elevation myocardial infarction groups than unstable angina oectoris group proposes a relationship between gamma-glutamyltransferase and severity of acute coronary syndromes.
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.
authors.forename: Mehmet Yunus
authors.initials: MY
authors.lastname: Emiroglu
authors.forename: Ozlem Batukan
authors.initials: OB
authors.lastname: Esen
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bulut
authors.forename: Hekim
authors.initials: H
authors.lastname: Karapinar
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakoyun
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kargin
authors.forename: Soe Moe
authors.initials: SM
authors.lastname: Aung
authors.forename: Elnur
authors.initials: E
authors.lastname: Alızade
authors.forename: Selcuk
authors.initials: S
authors.lastname: Pala
authors.forename: Ali Metin
authors.initials: AM
authors.lastname: Esen