title: Flecainide suppresses defibrillator-induced storming in catecholaminergic polymorphic ventricular tachycardia.
abstract: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition associated with ventricular tachycardia (VT) triggered by exercise or sympathetic stress. Incessant VT may develop due to defibrillator-induced storming-a condition where implantable cardioverter-defibrillator discharges result in a hyperadrenergic state, provoking further VT and defibrillator discharge. We describe the case of a 14-year-old boy with CPVT caused by a calsequestrin-2 mutation, who presented with defibrillator-induced storming refractory to β-blockers, calcium-channel blockers, amiodarone, and dronedarone. Flecainide and β-blocker use suppressed incessant VT and defibrillator-induced storming.
authors.affiliation: The Queen's Medical Center, John A. Burns School of Medicine, Department of Internal Medicine, Division of Cardiology John A. Burns School of Medicine, Department of Internal Medicine, Honolulu, Hawaii 96813, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hong
authors.forename: Kahealani K
authors.initials: KK
authors.lastname: Rivera
authors.forename: Arksarapuk
authors.initials: A
authors.lastname: Jittirat
authors.forename: Joon J
authors.initials: JJ
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D017147:Defibrillators, Implantable / Q000009:adverse effects*; D005424:Flecainide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide