title: A pulsatile control algorithm of continuous-flow pump for heart recovery.
abstract: The intra-aorta pump is a novel continuous flow (CF) left ventricular (LV) device. According to literatures, the pulsatile flow LV device can provide superior LV unloading and circulatory support compared with CF LV assist devices at the same level of ventricular assist device flow. Therefore, a pulsatile control algorithm for the intra-aorta pump is designed. It can regulate the pump to generate pulsatile arterial pressure (AP) and blood flow. A mathematic model of the cardiovascular-pump system is used to verify the feasibility of the control strategy in the presence of LV failure. The surplus hemodynamic energy (SHE), pulsatile ratio (PR), and pulsatile attenuation index (PAI) are used to evaluate the pulsatility of AP and blood flow. The SHE is 8,012.0 ergs/cm(3) by using the pulsatile control strategy (PCS) compared with 5,630.0 ergs/cm(3) by failing heart without support. The PR is 0.302 in the PCS vs. 0.315 in failing heart without support. Meanwhile, the PAI is 85.9% in the PCS compared with 69.7% in failing heart without support. The results demonstrate that the presented control strategy can maintain the pulsatility of AP and blood flow. Moreover, the pulsatile controller provides notably LV unloading. To test the response of the controller to the change of blood demand of patients, another simulation is conducted. In this simulation, the peripheral resistance is reduced to mimic the status of a slight physical active; the Emax is increased to simulate the ventricular contractility recovery. The simulation results demonstrate that the proposed control strategy can automatically regulate the pump in response to the change of the parameters of the circulatory system. To test the dynamic character of the intra-aorta pump, an in vitro experiment is conducted on an in vitro experiment rig. The experimental results demonstrate that the intra-aorta pump can achieve the pulsatile pump speed calculated by the pulsatile controller. The PCS is feasible for the intra-aorta pump. As a key feature, the proposed control strategy provides adequate perfusion in response to the change of blood demands of patients, while restoring the pulsatility of AP and blood flow.
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Gu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Youjun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D001021:Aortic Valve / Q000473:pathology; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D002309:Cardiology / Q000379:methods*; D004867:Equipment Design; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000628:therapy; D006352:Heart Ventricles / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D011673:Pulsatile Flow; D018487:Ventricular Dysfunction, Left / Q000628:therapy