title: In-hospital death in acute coronary syndrome was related to admission glucose in men but not in women.
abstract: BACKGROUND
  Admission hyperglycaemia is associated with mortality in patients with acute coronary syndrome (ACS), but controversy exists whether hyperglycaemia uniformly affects both genders. We evaluated coronary risk factors, gender, hyperglycaemia and their effect on hospital mortality.
  
  
  METHODS
  959 ACS patients (363 women and 596 men) were grouped based on glycaemia ≥ or < 200 mg/dL and gender: men with glucose < 200 mg/dL (menG-); women with glucose < 200 mg/dL (womenG-); men with glucose ≥ 200 mg/dL (menG+); and women with glucose ≥ 200 mg/dL (womenG+). A logistic regression analysis compared the relation between gender and glycaemia groups and death, adjusted for coronary risk factors and laboratory data. RESULTS GROUP: menG- had lower mortality than menG + (OR = 0.172, IC95% 0.062-0.478), and womenG + (OR = 0.275, IC95% 0.090-0.841); womenG- mortality was lower than menG + (OR = 0.230, IC95% 0.074-0.717). No difference was found between menG + vs womenG + (p = 0.461), or womenG- vs womenG + (p = 0.110). Age (OR = 1.067, IC95% 1.031-1.104), EF (OR = 0.942, IC95% 0.915-0.968), and serum creatinine (OR = 1.329, IC95% 1.128-1.566) were other independent factors related to in-hospital death.
  
  
  CONCLUSIONS
  Death was greater in hyperglycemic men compared to lower blood glucose men and women groups, but there was no differences between women groups in respect to glycaemia after adjustment for coronary risk factors.
authors.affiliation: Heart Institute-InCor, University of São Paulo Medical School, Avenue Enéas de Carvalho de Aguiar 44, 05403-000 São Paulo, Brazil. julio.takada@incor.usp.br
authors.forename: Julio Yoshio
authors.initials: JY
authors.lastname: Takada
authors.forename: Rogério Bicudo
authors.initials: RB
authors.lastname: Ramos
authors.forename: Larissa Cardoso
authors.initials: LC
authors.lastname: Roza
authors.forename: Solange Desiree
authors.initials: SD
authors.lastname: Avakian
authors.forename: José Antonio Franchini
authors.initials: JA
authors.lastname: Ramires
authors.forename: Antonio de Pádua
authors.initials: Ade P
authors.lastname: Mansur
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality*; D000367:Age Factors; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001938:Brazil; D003955:Diagnostic Tests, Routine; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose