title: Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group.
abstract: An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Yang
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006900:Hydroxylation; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D001565:Benzoates; D004952:Esters; D016877:Oxidants; D012428:Ruthenium; C051230:4-ethylbenzoic acid; D014269:Trifluoroacetic Acid