title: [Intima-media thickness in obese adolescents and their relation with metabolic syndrome].
abstract: BACKGROUND
  Obese adolescents have higher cardiovascular risk (CVR). Intima-media thickness (IMT) detects early arterial vascular compromise.
  
  
  OBJECTIVE
  To evaluate whether obese adolescents have higher vascular compromise measured by IMT than nonobese adolescents, and if this is greater in those with metabolic syndrome (MS).
  
  
  METHODS
  The study group (SG), obese children (BMI/age > p95), with and without MS and control group (CG), non-obese (BMI/age p10-85) and non nutritional or endocrine disease. We measured serum lipids, oral glucose tolerance test with insulin and carotid artery ultrasound. To evaluate the differences between test groups we used parametric and nonparametric statistics.
  
  
  RESULTS
  We evaluated 45 obese adolescents (20 women), 19 with MS, age 13 (9-16) years and 18 controls (14 women), aged 13 (11-16) years. IMT of carotid bulb and internal carotid artery (ICA) were significantly higher in SG than CG (0.54 vs. 0.34, 0.34 vs. 0.25, p < 0.05). There was no difference between obese groups. IMT of ICA and bulb correlated positively with BMIz (r = 0.3 and 0.6, p < 0.05) and with waist circumference (CC) (r = 0.3 and 0.55, p < 0, 05). IMT of ICA was positively correlated with fasting insulin, HOMA and systolic blood pressure. In multivariate analysis only BMI and CC were associated independently to IMT.
  
  
  CONCLUSIONS
  Obesity is an early risk factor for cardiovascular damage measured by IMT and IMT of ICA demonstrated a higher correlation with cardiovascular risk factors.
authors.affiliation: Departamento de Pediatría y Cirugía Infantil Norte, Universidad de Chile, Hospital Roberto del Rio, Santiago, Chile. torrejon_clau@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Torrejón
authors.forename: M
authors.initials: M
authors.lastname: Hevia
authors.forename: E
authors.initials: E
authors.lastname: Ureta
authors.forename: X
authors.initials: X
authors.lastname: Valenzuela
authors.forename: P
authors.initials: P
authors.lastname: Balboa
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002339:Carotid Arteries / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D009765:Obesity / Q000000981:diagnostic imaging / Q000473:pathology*; D012306:Risk; D012737:Sex Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D014652:Vascular Diseases / Q000473:pathology; D055105:Waist Circumference
chemical_list: D007328:Insulin; D008055:Lipids