title: Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer.
abstract: We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p=0.04), with low histological grade (p=0.04), with positive hormone receptor status (p=0.01), and in patients without recurrence (p=0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival.
authors.affiliation: Pamukkale University, Medical Faculty, Department of Medical Oncology, Denizli, Turkey. arzu_yaren@yahoo.com
authors.forename: Arzu
authors.initials: A
authors.lastname: Yaren
authors.forename: Sebahat
authors.initials: S
authors.lastname: Turgut
authors.forename: Ceylan
authors.initials: C
authors.lastname: Ayada
authors.forename: Raziye
authors.initials: R
authors.lastname: Akcilar
authors.forename: Serkan
authors.initials: S
authors.lastname: Degirmencioglu
authors.forename: Gamze
authors.initials: G
authors.lastname: Gokoz Dogu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: D007334:Insulin-Like Growth Factor I