title: Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations.
abstract: Respiratory syncytial virus (RSV) infection in children can be associated with acute encephalopathy. However, the roles of cytokines in the cerebrospinal fluid (CSF) of such patients remain unevaluated. In this study, a profile of 17 cytokines was determined for eight RSV-infected children with neurological complications. In one patient with high levels of 13 cytokines, a cytokine storm was considered to have occurred. Interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1β levels were also high in other patients. These data suggest that chemokines in CSF play roles in neurological complications in RSV-infected children.
authors.affiliation: Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. hisashi@tokyo-med.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kashiwagi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ioi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Morichi
authors.forename: Shingo
authors.initials: S
authors.lastname: Oana
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
authors.forename: Jun
authors.initials: J
authors.lastname: Sawai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kato
mesh_terms: D020805:Central Nervous System Viral Diseases / Q000134:cerebrospinal fluid* / Q000821:virology; D018925:Chemokines / Q000096:biosynthesis* / Q000134:cerebrospinal fluid* / Q000235:genetics; D002675:Child, Preschool; D005260:Female; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D018357:Respiratory Syncytial Virus Infections / Q000134:cerebrospinal fluid* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D018925:Chemokines; D012367:RNA, Viral