title: A technique for visualization and mapping of local cartilage thickness changes in MR images of osteoarthritic knee.
abstract: OBJECTIVE
  The aim of this paper is to describe a technique for the visualization and mapping of focal, local cartilage thickness changes over time in magnetic resonance images of osteoarthritic knee.
  
  
  METHODS
  Magnetic resonance imaging was performed in 25 fresh frozen pig knee joints and 15 knees of patients with borderline to mild osteoarthritis (51.2±6.3 years). Cartilage and corresponding bone structures were extracted by semi-automatic segmentation. Each point in the bone surface which was part of the bone-cartilage interface was assigned a cartilage thickness value. Cartilage thicknesses were computed for each point in the bone-cartilage interfaces and transferred to the bone surfaces. Moreover, we developed a three dimensional registration method for the identification of anatomically corresponding points of the bone surface to quantify local cartilage thickness changes. One of the main advantages of our method compared to other studies in the field of registration is a global optimization algorithm that does not require any initialization.
  
  
  CONCLUSIONS
  The registration accuracy was 0.93±0.05 mm (less than a voxel of magnetic resonance data). Local cartilage thickness changes were seen as having follow-up clinical study for detecting local changes in cartilage thickness. Experiment results suggest that our method was sufficiently accurate and effective for monitoring knee joint diseases.
authors.affiliation: Department of Radiology, Weihai Municipal Hospital, Weihai City, Shandong Province, 164200, China. gequanxu@yahoo.com.cn
authors.forename: Quanxu
authors.initials: Q
authors.lastname: Ge
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Cheng
authors.forename: Kesen
authors.initials: K
authors.lastname: Bi
authors.forename: Changyong
authors.initials: C
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000465:Algorithms; D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size; D020370:Osteoarthritis, Knee / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine