title: Genetic regulation of thymocyte progenitor aging.
abstract: The number of T cell progenitors is significantly reduced in the involuted thymus, and the growth and developmental potential of the few cells that are present is severely attenuated. This review provides an overview of how aging affects T cell precursors before and following entry into the thymus and discusses the age-related genetic changes that may occur in them. Finally, interventions that rejuvenate thymopoiesis in the elderly by targeting T cell progenitors are discussed.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.
authors.forename: Beata
authors.initials: B
authors.lastname: Berent-Maoz
authors.forename: Encarnacion
authors.initials: E
authors.lastname: Montecino-Rodriguez
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dorshkind
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D005786:Gene Expression Regulation; D006801:Humans; D038041:Lymphopoiesis; D054504:Precursor Cells, T-Lymphoid / Q000166:cytology / Q000276:immunology*; D060168:Thymocytes / Q000166:cytology / Q000276:immunology*