title: Chromatin signatures of active enhancers.
abstract: Gene-distal cis-regulatory sequences, such as enhancers, are key contributors of tissue-specific gene expression. In particular, enhancers can be located up to hundreds of kilobases from the promoters that they control, making their identification challenging. Thanks to the recent technological advances to map histone modifications and chromatin-associated factors genome-wide, several studies have begun to characterize chromatin signatures of active enhancers. Here, we discuss some of these results and how they provide new insights into the tissue-specific organization of enhancer repertoires.
authors.affiliation: Inserm, UMR_S 928, TAGC, Marseille, France. spicuglia@tagc.univ-mrs.fr
authors.forename: Salvatore
authors.initials: S
authors.lastname: Spicuglia
authors.forename: Laurent
authors.initials: L
authors.lastname: Vanhille
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D023281:Genomics; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D012319:RNA Polymerase II