title: TFIIH: when transcription met DNA repair.
abstract: The transcription initiation factor TFIIH is a remarkable protein complex that has a fundamental role in the transcription of protein-coding genes as well as during the DNA nucleotide excision repair pathway. The detailed understanding of how TFIIH functions to coordinate these two processes is also providing an explanation for the phenotypes observed in patients who bear mutations in some of the TFIIH subunits. In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UdS, BP 163, 67404 Illkirch Cedex, C. U., Strasbourg, France. compe@igbmc.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Compe
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Egly
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000235:genetics*; D004194:Disease; D006801:Humans; D008957:Models, Genetic; D051758:Transcription Factor TFIIH / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D051758:Transcription Factor TFIIH