title: Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development.
abstract: Toll-like receptor (TLR) activation may be an important event in tumor cell immune evasion. TLR2 and TLR4 gene polymorphisms have been related to increased susceptibility to cancer development in various organs. 261 patients and 480 health individuals were investigated for genotype and allelic frequencies of a 22-bp nucleotide deletion (-196 to -174del) in the promoter of TLR2 gene as well as two polymorphisms causing amino acid substitutions (Asp299Gly and Thr399Ile) in TLR4 gene. As far as (-196 to -174del) in TLR2 gene is concerned ins/del and del/del genotypes and del allele were significantly more frequent in breast cancer patients compared to healthy controls. Considering Asp299Gly replacement of TLR4 gene, Gly carriers (Asp/Gly & Gly/Gly genotype) and Gly allele were overrepresented among the breast cancer cases. The -174 to -196del of TLR2 gene and Asp299Gly of TLR4 gene polymorphisms may confer an increased susceptibility to breast cancer development.
authors.affiliation: First Propaedeutic Surgical Dept, School of Medicine, Hippocratio General Hospital, Athens, Greece.
authors.forename: George E
authors.initials: GE
authors.lastname: Theodoropoulos
authors.forename: Vasilios
authors.initials: V
authors.lastname: Saridakis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Karantanos
authors.forename: Nikolaos V
authors.initials: NV
authors.lastname: Michalopoulos
authors.forename: Flora
authors.initials: F
authors.lastname: Zagouri
authors.forename: Panagiota
authors.initials: P
authors.lastname: Kontogianni
authors.forename: Maria
authors.initials: M
authors.lastname: Lymperi
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
authors.forename: George C
authors.initials: GC
authors.lastname: Zografos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054458:Amplified Fragment Length Polymorphism Analysis; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017384:Sequence Deletion; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4