title: Medical conditions and risk of adult myeloid leukemia.
abstract: OBJECTIVE
  Although a few previous studies have reported positive associations between adult myeloid leukemia and a history of certain medical conditions, the etiology of most cases remains largely unknown. Our purpose was to examine associations between certain medical conditions and adult myeloid leukemia.
  
  
  METHODS
  Using logistic regression, we evaluated associations between 16 self-reported medical conditions and myeloid leukemia in a case-control study of 670 cases [including 420 acute myeloid leukemia (AML) and 186 chronic myelogenous leukemia (CML)] and 701 population-based controls.
  
  
  RESULTS
  We observed significant positive associations between AML and ulcerative colitis (odds ratio (OR) = 3.8; 95 % confidence interval (CI), 1.1-13) and between CML and peptic ulcer (OR = 2.0; 95% CI, 1.1-3.8). A personal cancer history increased both AML (OR = 2.6; 95% CI, 1.7-3.9) and CML (OR = 3.5; 95% CI, 2.0-5.8) risk even after excluding individuals who reported prior radiation and/or chemotherapy treatment.
  
  
  CONCLUSIONS
  Certain inflammatory medical conditions and a personal history of cancer, independent from therapy, are associated with an increased risk of myeloid leukemia.
authors.affiliation: Brown School, Washington University in St. Louis, MO 63130, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Johnson
authors.forename: Cindy M
authors.initials: CM
authors.lastname: Blair
authors.forename: James M
authors.initials: JM
authors.lastname: Fink
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Roesler
authors.forename: Betsy A
authors.initials: BA
authors.lastname: Hirsch
authors.forename: Phuong L
authors.initials: PL
authors.lastname: Nguyen
authors.forename: Julie A
authors.initials: JA
authors.lastname: Ross
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications; D005260:Female; D006304:Health Status; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D007951:Leukemia, Myeloid / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010437:Peptic Ulcer / Q000150:complications; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult