title: Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population.
abstract: OBJECTIVE
  To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper.
  
  
  METHODS
  We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  The literature search yielded 448 studies, in which 10 case-control studies including 1694 cases and 1456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers.
  
  
  CONCLUSIONS
  In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population.
authors.affiliation: Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University School of Medicine, Shaanxi, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yu
authors.forename: En-qi
authors.initials: EQ
authors.lastname: Liu
authors.forename: Si-hai
authors.initials: SH
authors.lastname: Zhao
authors.forename: Ya-feng
authors.initials: YF
authors.lastname: Li
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Wang
authors.forename: Yu-long
authors.initials: YL
authors.lastname: Chen
authors.forename: Ke-na
authors.initials: KN
authors.lastname: Wei
authors.forename: Bing-qiao
authors.initials: BQ
authors.lastname: Huang
authors.forename: Jian-lin
authors.initials: JL
authors.lastname: Fan
authors.forename: Peng-hui
authors.initials: PH
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D053480:Cholesterol Ester Transfer Proteins