title: Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.
abstract: The etiology of Parkinson's disease (PD) is attributed to both environmental and genetic factors. The development of PD reportedly involves mitochondrial impairment, oxidative stress, α-synuclein aggregation, dysfunctional protein degradation, glutamate toxicity, calcium overloading, inflammation and loss of neurotrophic factors. Based on a link between mitochondrial dysfunction and pesticide exposure, many laboratories, including ours, have recently developed parkinsonian models by utilization of rotenone, a well-known mitochondrial complex I inhibitor. Rotenone models for PD appear to mimic most clinical features of idiopathic PD and recapitulate the slow and progressive loss of dopaminergic (DA) neurons and the Lewy body formation in the nigral-striatal system. Notably, potential human parkinsonian pathogenetic and pathophysiological mechanisms have been revealed through these models. In this review, we summarized various rotenone-based models for PD and discussed the implied etiology of and treatment for PD.
authors.affiliation: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430022, China.
authors.forename: Nian
authors.initials: N
authors.lastname: Xiong
authors.forename: Xi
authors.initials: X
authors.lastname: Long
authors.forename: Jing
authors.initials: J
authors.lastname: Xiong
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.forename: Chunnuan
authors.initials: C
authors.lastname: Chen
authors.forename: Jinsha
authors.initials: J
authors.lastname: Huang
authors.forename: Devina
authors.initials: D
authors.lastname: Ghoorah
authors.forename: Xiangquan
authors.initials: X
authors.lastname: Kong
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Lin
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000187:drug effects / Q000473:pathology; D006801:Humans; D016631:Lewy Bodies / Q000187:drug effects / Q000473:pathology; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000209:etiology / Q000473:pathology*; D059748:Proteolysis / Q000187:drug effects; D012402:Rotenone / Q000633:toxicity*; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein; D012402:Rotenone