title: Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients.
abstract: OBJECTIVE
  To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA(1c)).
  
  
  METHODS
  Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA(1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA(1c) level, the patients were divided into three groups, group A (HbA(1c) <7%, n=31), group B (7%≤HbA(1c)≤10%, n=48), and group C (HbA(1c) >10%, n=49). The correlation of HbA(1c) with lipid ratios & individual lipid indexes were analyzed.
  
  
  RESULTS
  With the increased level of HbA(1c), LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA(1c), without any significant differences between three groups. There was no significant correlation between HbA(1c) and TG or HDL-C. With the increased level of HbA(1c), TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid.
  
  
  CONCLUSIONS
  LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.
authors.affiliation: Department of Endocrine and Metabolism, Sichuan University Westchina Hospital, Chengdu, Sichuan, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yan
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides