title: Thrombocytosis following splenectomy: with or without additional organ resection.
abstract: OBJECTIVE
  Splenectomy is one of the main causes of reactive thrombocytosis. In most cases, thrombocytosis found incidentally is harmless and resolves spontaneously; however, extreme thrombocytosis may result in thrombotic events such as acute myocardial infarction, mesenteric vein thrombosis and pulmonary embolism. Thus, there are no clear indications for determining which patients with reactive thrombocytosis require treatment. In this study, we evaluated reactive thrombocytosis that developed after splenectomy with or without additional organ resection.
  
  
  METHODS
  We retrospectively studied 70 patients who underwent splenectomy. These patients were divided into 2 groups: the only splenectomy group (group A) and the splenectomy with additional organ resection group (group B).
  
  
  RESULTS
  Both the platelet count at 1 week and 1 month after the operation (p<0.01 and p<0.001, respectively) and the incidence rate of thrombocytosis at 1 week and 1 month (p<0.4089 and p<0.0007, respectively) were significantly higher in group A than in group B. All patients in both groups recovered from thrombocytosis without any platelet reduction therapy and there was no postoperative thrombosis.
  
  
  CONCLUSIONS
  Splenectomy often results in reactive thrombocytosis; however, platelet reduction therapy is not required for treating postsplenectomy reactive thrombocytosis.
authors.affiliation: Department of Surgery, Social Insurance Yokohama Central Hospital, Yokohama, Japan. ooida.takatsugu@yokochu.jp
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Oida
authors.forename: Hisao
authors.initials: H
authors.lastname: Kano
authors.forename: Kenji
authors.initials: K
authors.lastname: Mimatsu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawasaki
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kuboi
authors.forename: Nobutada
authors.initials: N
authors.lastname: Fukino
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Kida
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects*; D013922:Thrombocytosis / Q000209:etiology* / Q000628:therapy
chemical_list: D015850:Interleukin-6