title: Inflammation & apoptosis in spinal cord injury.
abstract: Spinal cord injury (SCI) consists of a two-steps process involving a primary mechanical injury followed by an inflammatory process and apoptosis. Secondary insult is characterized by further destruction of neuronal and glial cells, and leads to expansion of the damage, so that the paralysis can extend to higher segments. With the identification of mechanisms that either promote or prevent neuronal inflammation and apoptosis come new approaches for preventing and treating neurodegenerative disorders. From a clinical perspective, this article discusses novel targets for the development of therapeutic agents that have the potential to protect the spinal cord from irreversible damage and promote functional recovery.
authors.affiliation: Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yin
authors.forename: Sheng-Jie
authors.initials: SJ
authors.lastname: Xu
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Wu
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology*; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants