title: Increased lung cancer mortality among chrysotile asbestos textile workers is more strongly associated with exposure to long thin fibres.
abstract: BACKGROUND
  Animal data and physical models suggest that the carcinogenicity of asbestos fibres is related to their size and shape.
  
  
  OBJECTIVE
  To investigate the influence of fibre length and diameter on lung cancer risk in workers at asbestos textile mills in North Carolina and South Carolina, USA.
  
  
  METHODS
  Men and women (n=6136) who worked ≥30 days in production and were employed between 1940 and 1973 were enumerated and followed for vital status through 2003. A matrix of fibre size-specific exposure estimates was constructed using determinations of fibre numbers and dimensions through analysis of 160 historical dust samples by transmission electron microscopy. Associations of lung cancer mortality with metrics of fibre exposure were estimated by Poisson regression with adjustment for age, sex, race and calendar year.
  
  
  RESULTS
  Exposure to fibres throughout the range of length and diameter was significantly associated with increased risk of lung cancer. Models for fibres >5 μm long and <0.25 μm in diameter provided the best fit to the data, while fibres 5-10 μm long and <0.25 μm in diameter were associated most strongly with lung cancer mortality (log rate about 4% per IQR, p<0.001). When indicators of mean fibre length and diameter were modelled simultaneously, lung cancer risk increased as fibre length increased and diameter decreased.
  
  
  CONCLUSIONS
  The findings support the hypothesis that the occurrence of lung cancer is associated most strongly with exposure to long thin asbestos fibres. The relationship of cancer risk and fibre dimensions should be examined in cohorts exposed to other types of fibres.
authors.affiliation: Department of Epidemiology, College of Public Health, 984395 University of Nebraska Medical Center, Omaha, NE 68198, USA. dana.loomis@unmc.edu
authors.forename: Dana
authors.initials: D
authors.lastname: Loomis
authors.forename: John M
authors.initials: JM
authors.lastname: Dement
authors.forename: Leslie
authors.initials: L
authors.lastname: Elliott
authors.forename: David
authors.initials: D
authors.lastname: Richardson
authors.forename: Eileen D
authors.initials: ED
authors.lastname: Kuempel
authors.forename: Leslie
authors.initials: L
authors.lastname: Stayner
mesh_terms: D017632:Asbestos, Serpentine / Q000009:adverse effects* / Q000032:analysis; D002274:Carcinogens, Environmental / Q000009:adverse effects / Q000032:analysis; D004391:Dust / Q000032:analysis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000401:mortality; D008297:Male; D009657:North Carolina / Q000453:epidemiology; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D009790:Occupations; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D016012:Poisson Distribution; D012307:Risk Factors; D013022:South Carolina / Q000453:epidemiology; D013783:Textile Industry; D013784:Textiles; D014937:Work
chemical_list: D017632:Asbestos, Serpentine; D002274:Carcinogens, Environmental; D004391:Dust; D052638:Particulate Matter