title: Phosphatases in SMAD regulation.
abstract: SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.
authors.affiliation: MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH Dundee, Scotland, UK.
authors.forename: David L
authors.initials: DL
authors.lastname: Bruce
authors.forename: Gopal P
authors.initials: GP
authors.lastname: Sapkota
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D004330:Drosophila; D006801:Humans; D008954:Models, Biological; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism; D000071636:Protein Phosphatase 2C; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D010770:Phosphotransferases; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C; D010744:Phosphoric Monoester Hydrolases