title: Acridine: a versatile heterocyclic nucleus.
abstract: Acridine is a heterocyclic nucleus. It plays an important role in various medicines. A number of therapeutic agents are based on acridine nucleus such as quinacrine (antimalarial), acriflavine and proflavine (antiseptics), ethacridine (abortifacient), amsacrine and nitracine (anticancer), and tacrine. Acridine is obtained from high boiling fraction of coal tar. It is also obtained in nature from plant and marine sources. Acridine undergoes a number of reactions such as nucleophilic addition, electrophilic substitution, oxidation, reduction, reductive alkylation and photoalkylation. The present review article summarizes the synthesis, reaction, literature review and pharmaceutical importance of acridine.
authors.affiliation: Lord Shiva College of Pharmacy, Sirsa-125055, Haryana, India. rjangra_pchem@yahoo.com
authors.forename: Ramesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Mandeep
authors.initials: M
authors.lastname: Kaur
authors.forename: Meena
authors.initials: M
authors.lastname: Kumari
mesh_terms: D000019:Abortifacient Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000166:Acridines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000962:Antimalarials / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans
chemical_list: D000019:Abortifacient Agents; D000166:Acridines; D000891:Anti-Infective Agents, Local; D000962:Antimalarials; D000970:Antineoplastic Agents