title: Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice.
abstract: Curcuminoids are poorly water-soluble compounds with promising antimalarial activity. To overcome some of the drawbacks of curcuminoids, we explored the potential of liposomes for the intravenous delivery of curcuminoids in a model of mouse malaria. The curcuminoids-loaded liposomes were formulated from phosphatidylcholine (soy PC) by the thin-film hydration method. Antimalarial activity of curcuminoids-loaded liposomes alone and in combination with α/β arteether when administered intravenously, was evaluated in Plasmodium berghei infected mice. Animals treated with curcuminoids-loaded liposomes showed lower parasitemia and higher survival when compared to control group (no treatment). Importantly, the combination therapy of curcuminoids-loaded liposomes (40 mg/kg body wt) along with α/β arteether (30 mg/kg body wt) was able to not only cure infected mice but also prevented recrudescence. These data suggest that curcuminoids-loaded liposomes may show promise as a formulation for anti-malarial therapy.
authors.affiliation: Department of Biochemistry, Davangere University, Davangere, Karnataka, India.
authors.forename: N P
authors.initials: NP
authors.lastname: Aditya
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Chimote
authors.forename: Karthigayan
authors.initials: K
authors.lastname: Gunalan
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
authors.forename: Swati
authors.initials: S
authors.lastname: Patankar
authors.forename: Basavaraj
authors.initials: B
authors.lastname: Madhusudhan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins / Q000008:administration & dosage*; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000031:analogs & derivatives; D036381:Diarylheptanoids; D004195:Disease Models, Animal; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008081:Liposomes; D008288:Malaria / Q000188:drug therapy* / Q000517:prevention & control; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018517:Plant Roots / Q000737:chemistry; D010962:Plasmodium berghei / Q000187:drug effects*; D059808:Polyphenols / Q000008:administration & dosage
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D036381:Diarylheptanoids; D008081:Liposomes; D010936:Plant Extracts; D059808:Polyphenols; C034786:bisdemethoxycurcumin; D003474:Curcumin; C050229:demethoxycurcumin; C055141:artemotil