title: Urea activation of α-nitrodiazoesters: an organocatalytic approach to N-H insertion reactions.
abstract: The combination of a urea catalyst and an α-nitro-α-diazo ester gives rise to a reactive species able to undergo insertion into the N-H bonds of anilines. This new strategy to achieve N-H insertion reactivity is in contrast to typical metal-catalyzed conditions for the generation of carbenoids from α-diazocarbonyl compounds. This report includes the extension of the insertion reaction to a three-component coupling for the construction of α-amino-α-aryl esters in high yield.
authors.affiliation: The Ohio State University, Department of Chemistry, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
authors.forename: Sonia S
authors.initials: SS
authors.lastname: So
authors.forename: Anita E
authors.initials: AE
authors.lastname: Mattson