title: Acute generalized exanthematous pustulosis induced by the essential oil of Pistacia lentiscus.
abstract: Acute generalized exanthematous pustulosis (AGEP) is an uncommon pustular eruption characterized by small nonfollicular pustules on an erythematous background, sometimes associated with fever and neutrophilia. Over 90% of cases are drug-induced; however, it can be caused in rare cases by other agents. We report two cases of AGEP secondary to ingestion of Pistacia lentiscus essential oil, the first two such cases to our knowledge. The cutaneous morphology, disease course and histological findings were consistent with a definite diagnosis of AGEP, based on the criteria of the EuroSCAR study group. These two cases highlight the need to consider herbal extracts as a potential rare cause of AGEP and to ensure the safety of herbal medicines.
authors.affiliation: Department of Dermatology, La Rabta Hospital Tunis, Tunis, Tunisia. inesrania@myway.com
authors.forename: I
authors.initials: I
authors.lastname: Zaraa
authors.forename: S
authors.initials: S
authors.lastname: Ben Taazayet
authors.forename: S
authors.initials: S
authors.lastname: Trojjet
authors.forename: D
authors.initials: D
authors.lastname: El Euch
authors.forename: I
authors.initials: I
authors.lastname: Chelly
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: M
authors.initials: M
authors.lastname: Mokni
authors.forename: A
authors.initials: A
authors.lastname: Ben Osman
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced*; D000975:Antioxidants / Q000009:adverse effects; D005260:Female; D006801:Humans; D009822:Oils, Volatile / Q000009:adverse effects*; D027927:Pistacia / Q000009:adverse effects*; D010936:Plant Extracts / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D009822:Oils, Volatile; D010936:Plant Extracts