title: Flow-injection chemiluminescence and electrogenerated chemiluminescence determination of escitalopram oxalate in tablet form.
abstract: Rapid, simple and highly sensitive flow-injection (FI) chemiluminescence (CL) and flow-injection electrogenerated chemiluminescence (ECL) methods were developed for the determination of escitalopram oxalate (ESC), a selective serotonin reuptake inhibitor used as an antidepressant drug. The CL method was based on the CL reaction of ESC with acidic cerium(IV) and tris(2,2'-bipyridyl)ruthenium(II) (Ru(bipy)(3)(2)+). Various experimental parameters affecting CL intensity were carefully studied and optimised. The method enabled the determination of 0.001-50 µg/mL of ESC in bulk form with a correlation coefficient r = 0.9999. The limit of detection (LOD) was 0.01 ng/mL (S/N = 3). The ECL method was based on the ECL reaction of Ru(bipy)(3)(2)+ with the drug in an acidic medium, permitting the determination of ESC in the range of 0.00001-70 µg/mL with r = 0.9999 and LOD of 1 x 10(-4) ng/mL. The proposed methods were applied to the determination of ESC in commercial tablets. The results were compared statistically with those obtained from a published method using t- and F-tests.
authors.affiliation: Department of Chemistry, College of Science, King Saud University, PO Box 22452, Riyadh 11495, Saudi Arabia. nalarfaj@hotmail.com
authors.forename: Nawal A
authors.initials: NA
authors.lastname: Alarfaj
authors.forename: Fatma A
authors.initials: FA
authors.lastname: Aly
authors.forename: Abeer A
authors.initials: AA
authors.lastname: Al-Qahtany
mesh_terms: D015283:Citalopram / Q000032:analysis*; D017022:Flow Injection Analysis / Q000379:methods*; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D010070:Oxalates / Q000032:analysis*; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis*; D013607:Tablets / Q000032:analysis
chemical_list: D015283:Citalopram; D010070:Oxalates; D017367:Selective Serotonin Reuptake Inhibitors; D013607:Tablets