title: Formation of β-cyclodextrin inclusion enhances the stability and aqueous solubility of natural borneol.
abstract: The aims of this study were to optimize the preparation conditions of natural borneol/β-cyclodextrin (NB/β-CD) inclusion complex by ultrasound method, and to investigate its improvement of stability and solubility. The complex was characterized by different various spectroscopic techniques including Fourier transform infrared spectroscopy, X-ray diffractometry, and differential scanning calorimetry. The results demonstrate that NB could be efficiently loaded into β-CD to form an inclusion complex by ultrasound method at a molar ratio of 1: 1and mass ratio of 1: 6. The complex exhibited different physicochemical characteristics from that of free NB. Typically, formation of β-CD inclusion significantly enhanced the stability and aqueous solubility of NB.
  
  
  CONCLUSIONS
  Natural borneol (NB) has the potential to be widely used in the fields of medical and functional food, due to its specificity. However, the disadvantages of unstability in the preparation and storage process due to its easy sublimation and the low water solubility limit its application. This research provides an effective way to improve the solubility and stability of NB by preparing NB/β-CD inclusion complex. Furthermore, theoretical basis is also provided for the application development of NB.
authors.affiliation: College of Light Industry and Food Sciences, South China Univ of Technology, Guangzhou 510640, China. jysu@scut.edu.cn
authors.forename: Jianyu
authors.initials: J
authors.lastname: Su
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D001892:Camphanes / Q000008:administration & dosage / Q000737:chemistry*; D055598:Chemical Phenomena; D056831:Coordination Complexes / Q000737:chemistry / Q000528:radiation effects; D005503:Food Additives / Q000737:chemistry*; D061353:Food Storage; D005524:Food Technology; D019648:Foods, Specialized / Q000032:analysis; D057927:Hydrophobic and Hydrophilic Interactions; D008519:Medicine, Traditional; D012995:Solubility; D013016:Sound; D017550:Spectroscopy, Fourier Transform Infrared; D000074706:Sublimation, Chemical; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001892:Camphanes; D056831:Coordination Complexes; D005503:Food Additives; D047392:beta-Cyclodextrins; C031215:betadex; C022871:isoborneol