title: Malignant glomus tumour of larynx: first case report and literature review.
abstract: OBJECTIVE
  We describe the first reported case of a malignant glomus tumour of the larynx.
  
  
  METHODS
  Case report and review of the world literature concerning malignant glomus tumours.
  
  
  RESULTS
  A 37-year-old man presented with progressive hoarseness and dyspnoea. A smooth, right-sided laryngeal mass was found on flexible nasolaryngoscopy. Initial biopsy of this lesion was reported as a true 'glomus tumour', which is a benign lesion. Wide local excision was performed. The final histology of this specimen showed it to be a 'malignant glomus tumour'. Immunohistochemistry was positive for smooth muscle actin, collagen type IV, vimentin and cluster of differentiation 34 glycoprotein. Total laryngectomy was then performed as a definitive curative procedure.
  
  
  CONCLUSIONS
  Glomus tumour is rarely found in visceral locations. This tumour and its malignant counterpart are rare differential diagnoses of laryngeal masses.
authors.affiliation: Department of ENT, Head and Neck Surgery, Federal Post Graduate Medical Institute, Shaikh Zayed Hospital, Lahore, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Aslam
authors.forename: Z-U-S
authors.initials: ZU
authors.lastname: Qazi
authors.forename: A H
authors.initials: AH
authors.lastname: Ahmad
authors.forename: R U
authors.initials: RU
authors.lastname: Khan
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D001706:Biopsy; D005918:Glomus Tumor / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D007828:Laryngoscopy; D008297:Male; D008938:Mitosis; D009361:Neoplasm Invasiveness; D014139:Tracheostomy; D014746:Vimentin / Q000378:metabolism
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014746:Vimentin