title: Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis.
abstract: We describe a patient with severe atopic dermatitis and keratoconjunctivitis, who was prescribed both systemic and topical ciclosporin and who developed ocular surface squamous neoplasia (OSSN). To provide additional information on the incidence of the association between topical ciclosporin use and OSSN, we counted the total prescriptions for topical ciclosporin issued in our hospital between 2003 and 2006 (804 patients) and, for the same period, we reviewed the records of patients with OSSN for a history of treatment with ciclosporin or a history of atopy. No other case of OSSN in a patient with a history of topical ciclosporin use was identified, which makes it difficult to implicate topical ciclosporin as the causative factor.
authors.affiliation: Moorfields Eye Hospital, City Road, London, UK. tomhflynn@gmail.com
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Flynn
authors.forename: Bita
authors.initials: B
authors.lastname: Manzouri
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Tuft
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology*; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007637:Keratoconjunctivitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D008875:Middle Aged; D010784:Photomicrography