title: Evaluation of analgesic, anticonvulsant locomotor activities of alcoholic extract achyranthes bidentata blume in mice.
abstract: The alcoholic extract of Achyranthes bidentata (AAB) has been studied for analgesic, anticonvulsant and CNS depressant activities in animal models. Analgesic activity was studied using acetic acid-induced writing test for assessing peripheral analgesic effect and tail immersion test for central analgesic effect. Anticonvulsant activity was performed by maximal electroshock induced convulsions; while the locomotor activity was evaluated using actophotometer. AAB (250-500 mg/kg) significantly reduced the number of wriths induced by acetic acid and elevated pain threshold in hot water test. The extract (500mg/kg) exhibited anticonvulsant activity significantly (P<0.001) against tonic seizures induced by MES. The results of locomotor activity showed the significant (P<0.01) CNS depressant effect at the three doses (250,375 and mg/kg) employed. The results suggest that AAB exhibited analgesic, anticonvulsant and CNS depressant activity in a dose dependent pattern.
authors.affiliation: Adhiparashthi college of pharmacy, Melmaruvathur-603 319, India.
authors.forename: T
authors.initials: T
authors.lastname: Vetrichelvan
authors.forename: M
authors.initials: M
authors.lastname: Jegadeesan