title: Vitamin E: supplement versus diet in neurodegenerative diseases.
abstract: Contradicting outcomes have been observed in numerous studies investigating the benefits of vitamin E supplements in the context of neurodegenerative diseases. By reviewing epidemiological studies and clinical trials, it is found that dietary intake of vitamin E exhibits beneficial effects on neurodegeneration, whereas α-tocopherol supplements failed in most interventional trials. Potential reasons for why α-tocopherol supplements exhibit disappointing effects, especially compared with dietary intake, are put forward and implications for future studies are discussed.
authors.affiliation: Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P.R. China. shen@sdut.edu.cn
authors.forename: Liang
authors.initials: L
authors.lastname: Shen
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Ji
mesh_terms: D002986:Clinical Trials as Topic; D019587:Dietary Supplements / Q000032:analysis; D006801:Humans; D019636:Neurodegenerative Diseases / Q000178:diet therapy* / Q000188:drug therapy* / Q000517:prevention & control; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D014810:Vitamin E