title: Translational control in cellular and  developmental processes.
abstract: Growing evidence indicates that translational control of specific mRNAs contributes importantly to genetic regulation across the breadth of cellular and developmental processes. Synthesis of protein from a specific mRNA can be controlled by RNA-binding proteins at the level of translational initiation and elongation, and translational control is also sometimes coupled to mRNA localization mechanisms. Recent discoveries from invertebrate and vertebrate systems have uncovered novel modes of translational regulation, have provided new insights into how specific regulators target the general translational machinery and have identified several new links between translational control and human disease.
authors.affiliation: Department of Biology, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0T5, Canada.
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
authors.forename: Paul
authors.initials: P
authors.lastname: Lasko
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena / Q000235:genetics*; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D012333:RNA, Messenger; D016601:RNA-Binding Proteins