title: Mycophenolate mofetil-related pancolitis in a kidney transplant recipient.
abstract: Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient.  Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The patient's symptoms improved after we discontinued the mycophenolate mofetil. A repeat colonoscopy 2 months after we discontinued the mycophenolate mofetil showed reparative changes. Mycophenolate mofetil is an important drug in organ transplant immune-suppression regimens; however, with its widespread use, additional adverse effects continue to be recognized.
authors.affiliation: Department of Nephrology, Fattouma Bourguiba Hospital, Monastir, Tunisia. mouuna121@yahoo.fr
authors.forename: Mouna
authors.initials: M
authors.lastname: Hamouda
authors.forename: Houda
authors.initials: H
authors.lastname: Mahmoudi
authors.forename: Habib
authors.initials: H
authors.lastname: Skhiri
authors.forename: Mezri
authors.initials: M
authors.lastname: Elmay
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced* / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced / Q000473:pathology; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009173:Mycophenolic Acid