title: A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in East Asia.
abstract: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a clinically and radiologically distinct pontine-predominant perivascular neuroinflammation showing T lymphocyte infiltration. It is assumed to have an autoimmune or other inflammatory mediated pathogenesis. We report the first known case of CLIPPERS in East Asia, characterized by multiple punctate enhancement of the brainstem extending to the bilateral posterior limb of the internal capsule and caudal to the spinal cord conus. The patient had elevated IgE levels and a history of allergies, suggesting that lesions may arise from neuroinflammation in response to T lymphocyte infiltration into perivascular spaces.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan. rietohge@me.com
authors.forename: Rie
authors.initials: R
authors.lastname: Tohge
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagao
authors.forename: Akira
authors.initials: A
authors.lastname: Yagishita
authors.forename: Shiro
authors.initials: S
authors.lastname: Matsubara
mesh_terms: D002908:Chronic Disease; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D005202:Asia, Eastern; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D011149:Pons / Q000473:pathology*; D013256:Steroids / Q000627:therapeutic use*; D013577:Syndrome; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D013256:Steroids