title: Endovascular treatment of thoracoabdominal aortic aneurysms.
abstract: BACKGROUND
  Development in endograft design has extended endovascular treatment to include thoracoabdominal aortic aneurysms (TAAA). We report our experience using fenestrated and branched endografts in the management of TAAA.
  
  
  METHODS
  We analyzed a cohort of consecutive patients treated electively for TAAA using endovascular techniques between 2006 and 2011. All data were collected prospectively. The relationships between preoperative risk factors and clinical outcome were examined using univariate and multivariate statistical techniques. We also compared the outcomes between 33 previously published early cases (EC) with the last 56 later cases (LC).
  
  
  RESULTS
  Eighty-nine patients (83 men) were treated. Median age was 69 years. All patients were deemed unfit for open surgery. The 30-day and in-hospital mortality rates were 8.9% and 10%, respectively. Multivariate analysis showed in-hospital mortality was associated with preoperative chronic renal failure and advanced age. Higher postoperative mean arterial blood pressure was a protective factor. Technical success rate was 96.6% (94% and 98% in the EC and LC groups, respectively; P = .14). The spinal cord ischemia (SCI) rate was 7.8% (15% and 3% in the EC and LC groups, respectively; P = .063) and was associated with chronic obstructive pulmonary disease and procedure duration. Six patients (6.7%) required temporary filtration, but none required permanent renal support (associated with left ventricular ejection fraction <40% and procedure duration). Median procedure duration decreased from 232 to 203 minutes (P = .01) in the EC and LC groups, respectively. Actuarial survival was 86.8% ± 3.7% at 1 year and 74.7% ± 6% at 2 years.
  
  
  CONCLUSIONS
  Although we have treated a cohort at high operative risk, our midterm results compare favorably with the published series of conventional surgery. Accurate hemodynamic control represented by high-normal perioperative blood pressure seems to protect against severe postoperative complications.
authors.affiliation: Vascular Surgery, Hôpital Cardiologique, CHRU de Lille, Lille, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Guillou
authors.forename: Aurelia
authors.initials: A
authors.lastname: Bianchini
authors.forename: Jonathan
authors.initials: J
authors.lastname: Sobocinski
authors.forename: Blandine
authors.initials: B
authors.lastname: Maurel
authors.forename: Piervito
authors.initials: P
authors.lastname: D'elia
authors.forename: Mark
authors.initials: M
authors.lastname: Tyrrell
authors.forename: Richard
authors.initials: R
authors.lastname: Azzaoui
authors.forename: Stéphan
authors.initials: S
authors.lastname: Haulon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011474:Prosthesis Design; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome