title: Use of Flow Focusing® technology to produce tobramycin-loaded PLGA microparticles for pulmonary drug delivery.
abstract: In the present work, a promising formulation of an inhaled powder based on tobramycin-loaded microparticles has been reported. Biodegradable microparticles with controlled diameters in the range of 1-5 μm and narrow size distribution were synthesized by Flow Focusing® technology. Particles production was planned and optimized with the aid of a well-established mathematic model. Close agreements between theoretical an experimental sizes were obtained. To deliver a high payload of tobramycin to the lungs, the influence of surfactant concentration, polymer-drug ratio and initial drug concentration were investigated. For chosen formulations, drug delivery profiles were also studied. In some cases, it was found a controlled drug delivery for more than ten days, which could represent an important advance in the treatment of chronic lung infections. Other particles factors affecting deposit of an aerosol in the lung were also studied, such as surface charge and density.
authors.affiliation: Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, Seville, Spain. luciamartin@us.es
authors.forename: Lucia
authors.initials: L
authors.lastname: Martín-Banderas
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Holgado
authors.forename: Josefa
authors.initials: J
authors.lastname: Álvarez-Fuentes
authors.forename: Mercedes
authors.initials: M
authors.lastname: Fernández-Arévalo
mesh_terms: D000280:Administration, Inhalation; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D008168:Lung / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014031:Tobramycin / Q000008:administration & dosage
chemical_list: D004364:Pharmaceutical Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014031:Tobramycin