title: Body mass index and nonresponse to antiviral treatment in korean patients with genotype 2 and 3 chronic hepatitis C.
abstract: Pegylated-interferon plus ribavirin is the standard treatment for chronic hepatitis C. Sustained virological response (SVR) rates of up to 80% are reported in genotype 2 and 3 chronic hepatitis C cases. Obesity, a modifiable risk factor, may have a deleterious effect on antiviral treatment. We performed this study to examine the efficacy and safety of pegylated-interferon and ribavirin therapy in Korean patients with genotype 2 and 3 chronic hepatitis C and to investigate the risk factors for nonresponse to antiviral treatment. A total of 121 patients were treated with peginterferon alpha-2a 180 mcg/week plus ribavirin 800 mg/day for 24 weeks. The end-of-treatment virologic response (ETVR), the SVR, the end-of-treatment biochemical response (ETBR), the sustained biochemical response (SBR), and the adverse events were analyzed. The ETVR and SVR were 94.1% and 89.1%, respectively. The ETBR was 80.2% and the SBR was 96%. Multivariate analysis showed that a body mass index of 25 and over was the only independent factor that affected the SVR (odds ratio=10.5, 95% confidence interval: 2.006-54.948, p=0.005). Twenty patients (16.5%) dropped out at the end of treatment, and 7 (5.8%) patients discontinued treatment because of treatment-related adverse events. Our study showed that combination therapy with pegylated-interferon and ribavirin as an initial treatment for genotype 2 and 3 chronic hepatitis C is very effective and safe, and that body mass index is an independent risk factor for nonresponse to antiviral treatment in patients with genotype 2 and 3 chronic hepatitis C.
authors.affiliation: Department of Internal Medicine, Chonnam University Medical School, Gwangju, Korea.
authors.forename: Yeon Joo
authors.initials: YJ
authors.lastname: Kim
authors.forename: Sung Bum
authors.initials: SB
authors.lastname: Cho
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Hyoung Ju
authors.initials: HJ
authors.lastname: Hong
authors.forename: Du Hyeon
authors.initials: du H
authors.lastname: Lee
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Cho
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Kim
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Rew