title: Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes.
abstract: Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism in the skin and its subsequent distribution and clearance into systemic circulation from underlying tissues, play an essential role in this research area and are reviewed in this work.
authors.affiliation: Griffith University, School of Biomolecular and Physical Sciences and Queensland Micro- and Nanotechnology Centre, Brisbane, QLD, Australia. Y.Anissimov@Griffith.edu.au
authors.forename: Yuri G
authors.initials: YG
authors.lastname: Anissimov
authors.forename: Owen G
authors.initials: OG
authors.lastname: Jepps
authors.forename: Yuri
authors.initials: Y
authors.lastname: Dancik
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001692:Biological Transport; D016503:Drug Delivery Systems; D004781:Environmental Exposure; D006801:Humans; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations