title: Prognostic value of the periodontal risk assessment in patients with aggressive periodontitis.
abstract: OBJECTIVE
  Aim of the study was to evaluate the predictive value of the modified periodontal risk assessment (PRA) in patients with aggressive periodontitis (AgP) for the first time.
  
  
  METHODS
  A total of 86 Patients with AgP were re-examined 5-17 years after active periodontal treatment. Risk profile according to the modified PRA was assigned and regularity of maintenance monitored. Tooth loss, bone loss and recurrence of periodontitis were analysed in association with gender, diagnosis, compliance and risk profile using uni- and multivariate parametric regression and Cox proportional hazards models.
  
  
  RESULTS
  A total of 14 patients showed a localized AgP, 60 a high-risk-profile and 19 were compliant with the proposed maintenance-interval. Of 2202 teeth 98 were lost. Multivariate analysis could not assign a statistically significant impact to risk-profile. By excluding Interleukin-1 composite genotype from the modified PRA a significant influence (p = 0.003, HR 2.74) was detected. The impact of compliance was shown to be nearly significant (p = 0.059, HR 2.0). In patients with generalized AgP a tendency for increased tooth loss was found.
  
  
  CONCLUSIONS
  The prognostic value of the modified PRA could not be confirmed in patients with AgP. However, exclusion of Interleukin-1 composite genotype led to a model with significant influence on tooth loss.
authors.affiliation: Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, Germany. amelie.meyer-baeumer@med.uniheidelberg.de
authors.forename: Amelie
authors.initials: A
authors.lastname: Meyer-Bäumer
authors.forename: Maria
authors.initials: M
authors.lastname: Pritsch
authors.forename: Raluca
authors.initials: R
authors.lastname: Cosgarea
authors.forename: Nihad
authors.initials: N
authors.lastname: El Sayed
authors.forename: Ti-Sun
authors.initials: TS
authors.lastname: Kim
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
authors.forename: Bernadette
authors.initials: B
authors.lastname: Pretzl
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000150:complications / Q000628:therapy*; D016301:Alveolar Bone Loss / Q000209:etiology*; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005884:Gingival Hemorrhage / Q000209:etiology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D008297:Male; D010349:Patient Compliance; D010514:Periodontal Pocket / Q000209:etiology; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D012907:Smoking; D016388:Tooth Loss / Q000209:etiology*; D055815:Young Adult
chemical_list: D007375:Interleukin-1