title: Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.
abstract: The aim of the study was to determine the effect of tetramethylpyrazine phosphate tablets (TPT), a Chinese medicine used for cardiovascular disease, on immunity activity and oxidative injury in rats. Heart failure (HF) was induced by isoproterenol (ISO). After the animal model was established, the rats were administered the TPT by gavage (once a day). The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. TPT could decrease the levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Furthermore, it also could raise the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but reduce malonyldialdehyde (MDA) level. The results indicated that TPT improved cardiac function and myocardial fibrosis from myocardial injury, and this cardioprotection might be attributed to a reduction of oxidative stress and regulation of inflammation mediators.
authors.affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu-Weiqi Road, Jinan 250021, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Guo
authors.forename: Aihong
authors.initials: A
authors.lastname: Wang
authors.forename: Yongle
authors.initials: Y
authors.lastname: Sun
authors.forename: Chongen
authors.initials: C
authors.lastname: Xu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006333:Heart Failure / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis / Q000276:immunology; D007545:Isoproterenol; D008315:Malondialdehyde / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D010755:Organophosphates / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D011719:Pyrazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013607:Tablets; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D015850:Interleukin-6; D010755:Organophosphates; D011719:Pyrazines; D013607:Tablets; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D007545:Isoproterenol; C017953:tetramethylpyrazine