title: [Quantitative relationship of renal blood flow with size and density of glomeruli in rat postnatal ontogenesis].
abstract: The aim of the study was to find the quantitative relationship of postnatal changes in the glomeruli anatomic structure with the blood flow in kidneys. Kidney development was studied in 4-, 12-, 30-, and 65-day-old Wistar rats. Diameters of glomerulus (Dgl, microm), afferent and efferent arterioles (Daf and Def), and the glomeruli density (Ngl, mm(-3)) were measured posthumously. Volumes of one ((see text of symbol))V gl, microm3) and all glomeruli (see text for symbol)(sigma(see text for symbol)Vgl, mm3/cm3) and the glomeruli arterioles lumen (Saf and Sef, microm2) were calculated. The renal specific blood flow (SBF per unit of kidney weight, KW) was measured by the laser-Doppler flowmeter (in perfusion units, p.u.) under sodium barbamyl narcosis. We have found that, during postnatal growth, glomeruli morphological parameters vary according to the equations: Dgl = 7.1 (see text for symbol) KW0.41, (see text for symbol)V gl = 187 (see text for symbol) KW1.23, Ngl = 5309 (see text for symbol) KW-0.63 (KW, mg and for one kidney), Saf = 1.1 (see text for symbol)V gl 0.35, and Sef = 6.3 (see text for symbol) V gl 0.14. The renal SBF in 4-, 12-, and 65-day-old rats increases according to SBF = 6.7 (see text for symbol) (sigma( see text for symbol)V gl)0.98. The renal SBF calculated per unit of glomeruli volume varies a little with age.
authors.forename: U V
authors.initials: UV
authors.lastname: Shyyrapaĭ
authors.forename: V M
authors.initials: VM
authors.lastname: Belichenko
authors.forename: K A
authors.initials: KA
authors.lastname: Shoshenko
authors.forename: R I
authors.initials: RI
authors.lastname: Aĭzman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D007668:Kidney / Q000098:blood supply* / Q000254:growth & development*; D007678:Kidney Glomerulus / Q000033:anatomy & histology / Q000254:growth & development*; D017078:Laser-Doppler Flowmetry; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation