title: A comparative analysis of serologic parameters and oxidative stress in osteoarthritis and rheumatoid arthritis: reply to Mishra and colleagues.
abstract: In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and cholesterol levels is opposite. The metabolic pathway that underlies the production of cholesterol is the mevalonate pathway; it is also essential for the biosynthesis of isoprenoids involved in the control of several cell functions. This divergence of cholesterol levels, associated with these two inflammatory disorders, is probably due to a different etiology, pathogenesis, and progression.
authors.forename: M
authors.initials: M
authors.lastname: Girardelli
authors.forename: A M
authors.initials: AM
authors.lastname: Bianco
authors.forename: A
authors.initials: A
authors.lastname: Marcuzzi
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D010003:Osteoarthritis / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D018836:Inflammation Mediators; D008055:Lipids