title: Linking brain connectivity across different time scales with electroencephalogram, functional magnetic resonance imaging, and diffusion tensor imaging.
abstract: Structural and functional connectivity are intrinsic properties of the human brain and represent the amount of cognitive capacities of individual subjects. These connections are modulated due to development, learning, and disease. Momentary adaptations in functional connectivity alter the structural connections, which in turn affect the functional connectivity. Thus, structural and functional connectivity interact on a broad timescale. In this study, we aimed to explore distinct measures of connectivity assessed by functional magnetic resonance imaging and diffusion tensor imaging and their association to the dominant electroencephalogram oscillatory property at rest: the individual alpha frequency (IAF). We found that in 21 healthy young subjects, small intraindividual temporal IAF fluctuations were correlated to increased blood oxygenation level-dependent signal in brain areas associated to working memory functions and to the modulation of attention. These areas colocalized with functionally connected networks supporting the respective functions. Furthermore, subjects with higher IAF show increased fractional anisotropy values in fascicles connecting the above-mentioned areas and networks. Hence, due to a multimodal approach a consistent functionally and structurally connected network related to IAF was observed.
authors.affiliation: Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, University of Bern, Bern, Switzerland. jann@puk.unibe.ch
authors.forename: Kay
authors.initials: K
authors.lastname: Jann
authors.forename: Andrea
authors.initials: A
authors.lastname: Federspiel
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Giezendanner
authors.forename: Jennifer
authors.initials: J
authors.lastname: Andreotti
authors.forename: Mara
authors.initials: M
authors.lastname: Kottlow
authors.forename: Thomas
authors.initials: T
authors.lastname: Dierks
authors.forename: Thomas
authors.initials: T
authors.lastname: Koenig
mesh_terms: D000328:Adult; D001288:Attention; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen