title: Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis.
abstract: OBJECTIVE
  The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver.
  
  
  METHODS
  Patients with chronic viral hepatitis (n=101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled.
  
  
  RESULTS
  Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (-3.13+0.017×MMP2-0.019×haptoglobin and -0.270+0.007×HA-0.018×haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p=0.03), MMP2 (0.72/0.63, p=0.04), HA (0.79/0.76, p=0.94), Apo-A1 (0.56/0.48, p=0.73), and predictive logit-model (0.81/0.78, p=0.68) showed higher diagnostic value in the HV sample.
  
  
  CONCLUSIONS
  While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea.
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Suk
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Jong Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Kwang Hyub
authors.initials: KH
authors.lastname: Han
authors.forename: Ho Taik
authors.initials: HT
authors.lastname: Sung
authors.forename: So Hyung
authors.initials: SH
authors.lastname: Hong
authors.forename: Dae Yong
authors.initials: DY
authors.lastname: Kim
authors.forename: Jai Hoon
authors.initials: JH
authors.lastname: Yoon
authors.forename: Yeon Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Gwang Ho
authors.initials: GH
authors.lastname: Baik
authors.forename: Jin Bong
authors.initials: JB
authors.lastname: Kim
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D044963:Biopsy, Fine-Needle; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D016174:Hepacivirus / Q000472:pathogenicity; D006503:Hepatic Veins / Q000737:chemistry*; D006515:Hepatitis B virus / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000473:pathology / Q000821:virology*; D019698:Hepatitis C, Chronic / Q000473:pathology / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000821:virology; D016015:Logistic Models; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; C485359:HP protein, human; D006242:Haptoglobins; D010446:Peptide Fragments; D011347:Procollagen; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C041876:procollagen Type III-N-terminal peptide; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2