title: Intervention of TLR4 signal pathway cytokines in severe liver injury with obstructive jaundice in rats.
abstract: Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice.
authors.affiliation: Hunan Normal University, College of Physical Education, Changsha, China.
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: W M
authors.initials: WM
authors.lastname: Cai
authors.forename: C J
authors.initials: CJ
authors.lastname: Qin
authors.forename: L C
authors.initials: LC
authors.lastname: Miao
authors.forename: L T
authors.initials: LT
authors.lastname: Yun
authors.forename: Y
authors.initials: Y
authors.lastname: Hua
authors.forename: L
authors.initials: L
authors.lastname: Weilin
mesh_terms: D000818:Animals; D029972:Bupleurum / Q000737:chemistry*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000503:physiopathology / Q000628:therapy; D041781:Jaundice, Obstructive / Q000503:physiopathology / Q000628:therapy*; D008107:Liver Diseases / Q000503:physiopathology / Q000628:therapy; D008297:Male; D010805:Physical Conditioning, Animal / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D016207:Cytokines; D010936:Plant Extracts; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4