title: Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma.
abstract: BACKGROUND
  The purpose of this study was to determine whether lysosome-associated protein transmembrane-4 beta (LAPTM4B) overexpression is associated with the prognosis in patients with colorectal cancer.
  
  
  METHODS
  LAPTM4B expression was evaluated in colorectal cancer patients by Western blot analysis and immunohistochemistry. Univariate and multivariate analyses were performed to determine the association between LAPTM4B expression and prognosis.
  
  
  RESULTS
  Among the 136 patients with colorectal cancer, 51 patients had low LAPTM4B expression, and 85 patients had high LAPTM4B expression. The sensitivity and specificity of LAPTM4B overexpression were 62.5% and 100%, respectively. The 5-year overall survival (OS) rates for patients with high and low LAPTM4B expression were 37.38% and 98.04%, respectively (hazard ratio = 22.774; 95% confidence interval [CI], 5.287-98.091; P < .0001). The 5-year disease-free survival rate was 21.15% for patients in the high-expression group and 91.82% for patients in the low-expression group (hazard ratio = 11.674; 95% CI, 3.562-38.263; P < .0001).
  
  
  CONCLUSIONS
  LAPTM4B overexpression is an independent factor in colorectal cancer prognosis, and it may be an important potential biomarker.
authors.affiliation: Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Kang
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Haiyu
authors.initials: H
authors.lastname: Zhang
authors.forename: Bairong
authors.initials: B
authors.lastname: Xia
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Xue
authors.forename: Yuenan
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D015513:Oncogene Proteins / Q000378:metabolism*; D011379:Prognosis; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins