title: Aortic stiffness, left ventricle hypertrophy, and homogeneity of ventricle repolarization in adult dialyzed patients.
abstract: OBJECTIVE
  Study was designed to assess relationship between aortic compliance and homogeneity of heart electrical activity in dialysis patients.
  
  
  METHODS
  Study group was consisted of 120 dialyzed patients; 57 (age 50,7 ± 7,1) were on continuous ambulatory peritoneal dialysis (CAPD) and 73 (age 51,6 ± 7,6) were hemodialyzed (HD). Three-dimensional vectorocardiographic (VCG) monitoring was done to assess: QRS-T(angle), T(el) and T(az). Echocardiography was performed to assess: Ao(max), Ao(min), ASI (aortic siffness index).
  
  
  RESULTS
  ASI in HD as well as in CAPD patients was significantly higher compared to controls [resp., 5,51 (±1,32), 5,83 (±1,41), 3,07 (±1,09)]. Cut-off value of ASI was 5,67. In HD patients strong correlations between ASI and QRS-T(angle), T(el) and T(az) were determined (resp., r = 0,429, P < 0,001; r = 0,432, P ≤ 0,001 and r = 0,387, P = 0,001). In CAPD group were significant association between ASI and QRS-T(angle), T(el) and T(az) (resp., r = 0,452, P < 0,001; r = 0,417, P < 0,001 and r = 0,390, P = 0,001). ASI was independently and markedly associated with: QRS-T(angle), T(elev), T(az), ADMA, cTnT, CRP, Total-chol, LDL-chol in HD and CAPD patients.
  
  
  CONCLUSIONS
  ASI and VCG indices are higher in HD and CAPD patients. Correlation between ASI and VCG parameters may reflect unfavourable influence of poor aortic compliance on the electrical activity of the heart in dialyzed patients. Hypertrophy aggravates repolarization disturbances in hemodialyzed patients.
authors.affiliation: Department of Cardiology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland. zapolia@wp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zapolski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jaroszyński
authors.forename: Anna
authors.initials: A
authors.lastname: Drelich-Zbroja
authors.forename: Anna
authors.initials: A
authors.lastname: Wysocka
authors.forename: Jacek
authors.initials: J
authors.lastname: Furmaga
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wysokiński
authors.forename: Andrzej
authors.initials: A
authors.lastname: Książek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szczerbo-Trojanowska
authors.forename: Sławomir
authors.initials: S
authors.lastname: Rudzki
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001795:Blood Pressure Determination / Q000379:methods; D016022:Case-Control Studies; D055724:Electrophysiological Phenomena; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests; D006339:Heart Rate; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D006435:Renal Dialysis / Q000379:methods; D015203:Reproducibility of Results; D013997:Time Factors; D020107:Troponin T / Q000097:blood; D059289:Vascular Stiffness; D014672:Vectorcardiography / Q000379:methods*
chemical_list: D020107:Troponin T