title: Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population.
abstract: This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case-control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018-2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383-0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010-2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.
authors.affiliation: Key Lab of Genome Research of Anhui Province, Anhui Medical University, Hefei, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ruan
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: He
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Du
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Xian-Bo
authors.initials: XB
authors.lastname: Zuo
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Fang
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Cao
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics; D016022:Case-Control Studies; D018797:Cell Cycle Proteins / Q000235:genetics*; D002681:China; D004247:DNA / Q000097:blood; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013091:Spermatogenesis / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; C578814:TEX15 protein, human; D004247:DNA