title: [Development of mupirocin resistance during eradication treatment of methicillin resistant Staphylococcus aureus carriage].
abstract: We report a case of a 55 year-old male who was transferred to a Danish hospital from Central America. A routine screening revealed a methicillin resistant Staphylococcus aureus (MRSA) isolate sensitive to mupirocin (minimal inhibitory concentration (MIC) 0.094 mg/L) and eradication treatment was initiated. Three weeks later the patient developed MRSA bacteraemia with the same strain, though now resistant to mupirocin (MIC 8 mg/l). The incidence of mupirocin resistance is low in Denmark compared to other countries with a heavier burden of MRSA, but there is reason to be concerned due to the increasing reliance on this drug for treatment of MRSA carriage.
authors.affiliation: Klinisk Mikrobiologisk Afdeling, Aalborg Sygehus, Mølleparkvej 10, 9000 Aalborg, Denmark. kfk@rn.dk
authors.forename: Karina Frahm
authors.initials: KF
authors.lastname: Kirk
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008875:Middle Aged; D016712:Mupirocin / Q000302:isolation & purification / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D014195:Travel
chemical_list: D000900:Anti-Bacterial Agents; D016712:Mupirocin