title: Two cases of primary ciliary dyskinesia with different responses to macrolide treatment.
abstract: We herein report two cases of primary ciliary dyskinesia (PCD) with different responses to macrolides. Case 1: a 17-year-old Japanese man with Pseudomonas aeruginosa infection and combined defect of both inner and outer dynein arms in the cilia was unsuccessfully treated with long-term macrolides (clarithromycin, erythromycin, and azithromycin). Case 2: a 70-year-old Japanese man with deficiency of only the inner dynein arm was successfully treated with clarithromycin. Though the reasons for the different responses to macrolides are unclear, differences of ultrastructural abnormalities of the cilia might be one of the predictive factors in PCD just as in Pseudomonas aeruginosa infection.
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. t-kido@med.uoeh-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kido
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yatera
authors.forename: Kei
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Shuya
authors.initials: S
authors.lastname: Nagata
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Choujin
authors.forename: Chiyo
authors.initials: C
authors.lastname: Yamaga
authors.forename: Kanako
authors.initials: K
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Hisaoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D000293:Adolescent; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use; D006801:Humans; D007619:Kartagener Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D018942:Macrolides / Q000627:therapeutic use*; D008297:Male; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D017291:Clarithromycin