title: [Research progress of sarcolipin-a new regulatory protein of sarcoplasmic reticulum Ca2+ ATPase].
abstract: Sarcolipin (SLN) is a 3 kD membrane protein found in sarcoplasmic reticulum (SR). It has 31 amino acid residues; SLN and phopholamban (PLB) are belong to the same protein family, so they have similar physiological functions. SLN inhibits sarcoplasmic reticulum Ca(2+) ATPase (SERCA) activity and reduces its affinity of Ca(2+), resulting in dysfunction of myocardial contraction and heart failure. However, much remains to be elucidated. SLN independently or in conjunction with PLB affects SERCA activity, imbalancing intracellular calcium homeostasis, and reducing myocardial contractivity; these effects promote the development of heart failure.
authors.affiliation: Department of Pathology, College of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Baoping
authors.initials: B
authors.lastname: Yuan
authors.forename: Rong
authors.initials: R
authors.lastname: Lu
authors.forename: Yanpin
authors.initials: Y
authors.lastname: Gu
authors.forename: Yueling
authors.initials: Y
authors.lastname: Liao
authors.forename: Hongchang
authors.initials: H
authors.lastname: Wei
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D011510:Proteolipids / Q000378:metabolism / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000099211:Phospholamban
chemical_list: D002135:Calcium-Binding Proteins; D009124:Muscle Proteins; D011510:Proteolipids; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban; C077258:sarcolipin