title: Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues.
abstract: Acridin-1(2H)-one analogue of 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridine-2yl) methylene] acridin-1(2H)-one, 5 was prepared by using 7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one, 3 and picolinaldehyde, 4 in the presence of KOH at room temperature. These compounds were characterized by analytical and spectral analyses. The purpose of the present study was to assess the efficacy of larvicidal and repellent activity of synthesized 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues such as compounds 3 and 5 against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae). The compound exhibited high larvicidal effects at 50mg/L against both the mosquitoes with LC(50) values of 25.02 mg/L (r(2)=0.998) and 26.40 mg/L (r(2)=0.988) against C. quinquefasciatus and C. gelidus, respectively. The 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues that are reported for the first time to our best of knowledge can be better explored for the control of mosquito population. This is an ideal ecofriendly approach for the control of Japanese encephalitis vectors, C. quinquefasciatus and C. gelidus.
authors.affiliation: Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Subashini
authors.forename: A
authors.initials: A
authors.lastname: Bharathi
authors.forename: Selvaraj Mohana
authors.initials: SM
authors.lastname: Roopan
authors.forename: G
authors.initials: G
authors.lastname: Rajakumar
authors.forename: A
authors.initials: A
authors.lastname: Abdul Rahuman
authors.forename: Pavan Kumar
authors.initials: PK
authors.lastname: Gullanki
mesh_terms: D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003465:Culex / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000166:Acridines; D007306:Insecticides