title: [Clinicopathological study of calcifying cystic odontogenic tumors].
abstract: Calcifying cystic odontogenic tumors are benign tumors, characterized by the presence of ghost cells and calcified materials. We evaluated clinical characteristics of calcifying cystic odontogenic tumors in 21 cases at the Maxillofacial Surgery, Tokyo Medical and Dental University Hospital, between January 1979 and December 2006. Of the 21 lesions that were studied, 12 were observed in male patients, and 9 in female patients. The median age was 13.0 years (range, 4-69 years). Of the 21 lesions, 11 were located in the maxilla (intraosseous), 9 in the mandible (intraosseous), and 1 in the lower gingiva (extraosseous). Radiographically, 18 lesions appeared as unilocular radiolucencies, and 2 lesions as multilocular radiolucencies. Impacted teeth were observed in 15 cases. In 20 cases, the lesions were treated by enucleation. The follow-up duration ranged from 2 years, 5 months to 28 years, 8 months, and in 1 case, the lesion recurred and showed a malignant transformation 2 years 10 months after the treatment. Histopathologically, the lining epithelium consisted of cuboidal or columnar odontogenic cells. Ghost cells were frequently calcified, and the tissue was hardened. In 14 cases, the tumor was associated with odontoma.
authors.affiliation: Section of Maxillofacial Surgery, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Murashima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Michi
authors.forename: Kazuto
authors.initials: K
authors.lastname: Kurohara
authors.forename: Shin
authors.initials: S
authors.lastname: Iijima
authors.forename: Miho
authors.initials: M
authors.lastname: Suzuki
authors.forename: Aya
authors.initials: A
authors.lastname: Kawamata
authors.forename: Norihiko
authors.initials: N
authors.lastname: Okada
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamashiro
mesh_terms: D000293:Adolescent; D000328:Adult; D002114:Calcinosis / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008441:Maxillary Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000473:pathology*