title: Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis.
abstract: OBJECTIVE
  Recurrent respiratory papillomatosis (RRP) is a rare, benign, wart-like disease for which no curative treatment exists. The goal of treatment is total surgical removal of the epithelial lesions to keep the airway open and the voice sufficient. Therefore, it is essential to visualize all papillomatous lesions. The present study aims to evaluate the sensitivity of additional use of narrow band imaging (NBI) in detecting RRP during microlaryngoscopy.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Between January 2011 and July 2011, patients with RRP underwent systematic inspection during microlaryngoscopy using conventional white light (WL) immediately followed by inspection with NBI. Consensus was achieved about the number of lesions and number of RRP suspect lesions. All lesions were subsequently excised and sent for histopathological examination.
  
  
  RESULTS
  Eighty-six excisional biopsies were taken in 24 microlaryngoscopies performed in 14 RRP patients. Eleven out of the 13 additional biopsies taken, induced by the second inspection with NBI, proved to be papillomata after histopathological examination. The sensitivity increased from 80% with WL up to 97% with WL + NBI (P < .01), whereas the specificity remained poor (32% and 28%, respectively).
  
  
  CONCLUSIONS
  NBI is an additional diagnostic tool in increasing the sensitivity of visualizing papillomata during microlaryngoscopy.
authors.affiliation: Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, the Netherlands. r.e.a.tjonpiangi@umcg.nl
authors.forename: Robin E A
authors.initials: RE
authors.lastname: Tjon Pian Gi
authors.forename: Gyorgy B
authors.initials: GB
authors.lastname: Halmos
authors.forename: Bettien M
authors.initials: BM
authors.lastname: van Hemel
authors.forename: Edwin R
authors.initials: ER
authors.lastname: van den Heuvel
authors.forename: Bernard F A M
authors.initials: BF
authors.lastname: van der Laan
authors.forename: Boudewijn E C
authors.initials: BE
authors.lastname: Plaat
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging / Q000379:methods*; D004825:Epiglottis / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007828:Laryngoscopy / Q000379:methods*; D007830:Larynx / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000473:pathology* / Q000601:surgery; D012680:Sensitivity and Specificity; D014132:Trachea / Q000473:pathology / Q000601:surgery; D014827:Vocal Cords / Q000473:pathology / Q000601:surgery; D055815:Young Adult