title: [Molecular aspects of allergy to plant products. Part II. Pathogenesis-related proteins (PRs), apple allergenicity governed by Mal d 1 gene].
abstract: Of the plant allergens listed in the Official Allergen Database of the International Union of Immunological Societies, approximately 25% belong to the group of pathogenesis-related proteins (PRs). They have been classified into 17 PR families based on similarities in their amino acid sequence, enzymatic activities, or other functional properties. Plant-derived allergens have been identified with sequence similarities to PR families 2, 3, 4, 5, 8, 10, and 14. The main birch allergen in northern Europe is a class 10 (PR-10) protein from the European white birch (Betula pendula) termed Bet v 1. Pollen of other Fagales species contains PR-10 homologues that share epitopes with Bet v 1, as do several fruits, nuts and vegetables. Among the plant food fruits of the Rosaceae family are the most frequently responsible for allergenic reactions. It is documented, that approximately 2% of European population is allergic to apples. The article presents molecular characterization of PR-10 proteins with regard to their structure and function as well as apple Mal d 1 gene-determined allergenicity.
authors.affiliation: Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Ogrodnictwa i Architektury Krajobrazu, Katedra Genetyki Hodowli i Biotechnologii Roślin. kamilabokszczanin@o2.pl
authors.forename: Kamila Ł
authors.initials: KŁ
authors.lastname: Bokszczanin
authors.forename: Andrzej A
authors.initials: AA
authors.lastname: Przybyła
mesh_terms: D000485:Allergens / Q000235:genetics*; D000595:Amino Acid Sequence; D052179:Antigens, Plant / Q000235:genetics* / Q000276:immunology; D005638:Fruit / Q000235:genetics / Q000276:immunology; D027845:Malus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D010940:Plant Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D013045:Species Specificity; D014675:Vegetables / Q000235:genetics / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; C095551:MALD1 protein, Malus domestica; D010940:Plant Proteins; C053376:pathogenesis-related proteins, plant