title: Impact of catechol-o-methyltransferase polymorphisms on risperidone treatment for schizophrenia and its potential clinical significance.
abstract: OBJECTIVE
  The main aim was to study the effects of COMT polymorphisms on response of risperidone treatment for schizophrenia and investigate the correlation between memory function of schizophrenia patients and COMT polymorphisms.
  
  
  METHODS
  Subjects were 83 schizophrenic patients who were antipsychotic drug free at the initiation of this study. Peripheral blood samples were obtained to identify COMT polymorphisms by using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Clinical Global Impressions (CGI), Positive and Negative Syndrome Scale (PANSS) and Wechsler Memory Scale (WMS) test were used to assess the effect of risperidone treatment.
  
  
  RESULTS
  The Val/Met carriers showed a significant increase in change of P300 during treatment (P=0.032). Association of Val/Met carriers performed better than other genotypes (P=0.028). The mean plasma concentration of prolactin of Val/Val carriers was significantly lower (P=0.017).
  
  
  CONCLUSIONS
  The COMT polymorphisms may be a potential biomarker for clinical risperidone treatment in schizophrenia.
authors.affiliation: Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang, China. gaoshugui@sina.com
authors.forename: Shugui
authors.initials: S
authors.lastname: Gao
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Hu
authors.forename: Jia
authors.initials: J
authors.lastname: Cheng
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zhou
authors.forename: Yongming
authors.initials: Y
authors.lastname: Xu
authors.forename: Shuguang
authors.initials: S
authors.lastname: Xie
authors.forename: Shiyan
authors.initials: S
authors.lastname: Liu
authors.forename: Zaizhong
authors.initials: Z
authors.lastname: Li
authors.forename: Junming
authors.initials: J
authors.lastname: Guo
authors.forename: Jianyi
authors.initials: J
authors.lastname: Dong
authors.forename: Minfang
authors.initials: M
authors.lastname: Huang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011388:Prolactin / Q000097:blood; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D011388:Prolactin; D002394:Catechol O-Methyltransferase; D018967:Risperidone