title: Parametric imaging of myocardial viability using ¹⁵O-labelled water and PET/CT: comparison with late gadolinium-enhanced CMR.
abstract: OBJECTIVE
  The perfusable tissue index (PTI) is a marker of myocardial viability. Recent technological advances have made it possible to generate parametric PTI images from a single [(15)O]H(2)O PET/CT scan. The purpose of this study was to validate these parametric PTI images.
  
  
  METHODS
  The study population comprised 46 patients with documented or suspected coronary artery disease who were studied with [(15)O]H(2)O PET and late gadolinium-enhanced (LGE) cardiac magnetic resonance imaging (CMR).
  
  
  RESULTS
  Of the 736 myocardial segments included, 364 showed some degree of LGE. PTI and perfusable tissue fraction (PTF) diminished with increasing LGE. The areas under the curve of the PTI and PTF, used to predict (near) transmural LGE on CMR, were 0.86 and 0.87, respectively. Optimal sensitivity and specificity were 91 % and 73 % for PTI and 69 % and 87 % for PTF, respectively.
  
  
  CONCLUSIONS
  PTI and PTF assessed with a single [(15)O]H(2)O scan can be utilized as markers of myocardial viability in patients with coronary artery disease.
authors.affiliation: Department of Cardiology, VU University Medical Center, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands. s.dehaan@vumc.nl
authors.forename: Stefan
authors.initials: S
authors.lastname: de Haan
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Harms
authors.forename: Mark
authors.initials: M
authors.lastname: Lubberink
authors.forename: Cornelis P
authors.initials: CP
authors.lastname: Allaart
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Danad
authors.forename: Weena J Y
authors.initials: WJ
authors.lastname: Chen
authors.forename: Michaela
authors.initials: M
authors.lastname: Diamant
authors.forename: Albert C
authors.initials: AC
authors.lastname: van Rossum
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Paul
authors.initials: P
authors.lastname: Knaapen
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005682:Gadolinium; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007553:Isotope Labeling; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014022:Tissue Survival; D014057:Tomography, X-Ray Computed; D014867:Water
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water; D005682:Gadolinium