title: Do early MRI signals predict lesion size in a neonatal stroke rat model?
abstract: In this study, we compared lesion size by using VADC and VT2 at 0, 2, 5, 24, and 48 hours and histologic lesions at 48 hours in a P7 rat stroke model. The best correlation between VHISTO and VADC was at H0, and between VHISTO and VT2, at H2-H5. Early MR imaging signals allowed excluding "no-lesion" and "no-reflow" animals to help standardize this neonatal stroke model and predict lesion size.
authors.affiliation: CNRS 7102, Equipe HICD, Université Pierre et Marie Curie Paris-Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Fau
authors.forename: C
authors.initials: C
authors.lastname: Po
authors.forename: C
authors.initials: C
authors.lastname: Goyenvalle
authors.forename: P
authors.initials: P
authors.lastname: Meric
authors.forename: C
authors.initials: C
authors.lastname: Charriaut-Marlangue
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002545:Brain Ischemia / Q000175:diagnosis* / Q000473:pathology; D017536:Carotid Artery, Common / Q000473:pathology; D004195:Disease Models, Animal; D017352:Echo-Planar Imaging / Q000379:methods; D005544:Forecasting; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020768:Middle Cerebral Artery / Q000473:pathology; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion / Q000379:methods; D020521:Stroke / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors