title: Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides.
abstract: Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.
authors.affiliation: Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Wenxian
authors.initials: W
authors.lastname: Xie
authors.forename: Xiu
authors.initials: X
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Zou
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000812:Anhydrides / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry; D003538:Cystamine / Q000737:chemistry; D004123:Dimethylamines / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005688:Galactosamine / Q000031:analogs & derivatives* / Q000737:chemistry; D005977:Glutarates / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry; D008280:Magnetics; D056951:Photoelectron Spectroscopy; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000480:Alkynes; D000812:Anhydrides; D001386:Azides; D002234:Carbodiimides; D004123:Dimethylamines; D004220:Disulfides; D005977:Glutarates; D006020:Glycopeptides; C569266:N-ethyl-N'-(3-(dimethylamino)-propyl)carbodiimide; D011437:Propylamines; D012821:Silanes; C079643:glutaric anhydride; D005688:Galactosamine; D012822:Silicon Dioxide; C477625:amino-propyl-triethoxysilane; D003538:Cystamine; D052203:Ferrosoferric Oxide