title: Malignancy in solitary solid cold thyroid nodule.
abstract: Solitary thyroid nodule is a common endocrine problem. The main concern of solitary thyroid nodule lies in excluding the malignancy & to operate on as few patients as possible. Other than history & clinical examination, hormone assessment, USG of thyroid gland, radionuclide scan & FNAC were used to differentiate malignant nodules from benign ones. In this study 127 cases with solitary thyroid nodule of all age group & both sexes were included from Endocrine & Thyroid clinic of BSMMU. They were clinically & biochemically euthyroid & had cold nodule on radionuclide scan. USG & FNAC were done & subsequently they underwent surgical procedure. On the basis of postoperative histopathological report the specimens were divided into benign & malignant groups. All the nodules were cold among which 104 were solid & 23 were mixed in consistency. Of the 104 solid cold nodules histopathology revealed 36(34.6%) malignant & 68(65.4%) benign cases. From the 23 mixed cold solitary nodule 5(21.7%) appeared malignant & 18(78.3%) were benign. So malignancy was higher in solid cold group than the mixed cold one but this was not statistically significant (p=0.673). FNAC was done & it revealed that 83(65.5%) cases were benign, 10(7.8%) cases were suspicious & 34(26.7%) were malignant. Finally histopathology showed 41(32.3%) cases were positive & 86(67.7%) cases were negative for malignancy.
authors.affiliation: Head Endocrine Wing (White Unit) Department of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. dr.md.fariduddin@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Fariduddin
authors.forename: A H
authors.initials: AH
authors.lastname: Amin
authors.forename: M U
authors.initials: MU
authors.lastname: Ahmed
authors.forename: S S
authors.initials: SS
authors.lastname: Karim
authors.forename: F
authors.initials: F
authors.lastname: Moslem
authors.forename: M
authors.initials: M
authors.lastname: Kamal
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D006042:Goiter / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D055815:Young Adult