title: Synthesis of 1,5-benzodiazepine and its derivatives by condensation reaction using H-MCM-22 as catalyst.
abstract: A simple and versatile method for the synthesis of 1,5-benzodiazepines is via condensation of o-phenylenediamines (OPDA) and ketones in the presence of catalytic amount of H-MCM-22 using acetonitrile as solvent at room temperature. In all the cases, the reactions are highly selective and are completed within 1-3 h. The method is applicable to both cyclic and acyclic ketones without significant differences. The reaction proceeds efficiently under ambient conditions with good-to-excellent yields.
authors.affiliation: SOS in Chemistry, Jiwaji University, Gwalior, India.
authors.forename: Sheikh Abdul
authors.initials: SA
authors.lastname: Majid
authors.forename: Waheed Ahmad
authors.initials: WA
authors.lastname: Khanday
authors.forename: Radha
authors.initials: R
authors.lastname: Tomar
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D010655:Phenylenediamines / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D017641:Zeolites / Q000737:chemistry
chemical_list: D007659:Ketones; D010655:Phenylenediamines; D001569:Benzodiazepines; D017641:Zeolites