title: A new diterpene from the leaves of Andrographis paniculata Nees.
abstract: Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3, 14-deoxyandrographolide 4, 14-deoxy-12-hydroxyandrographolide 5, 14-deoxy-11,12-dihydroandrographolide 6, neoandrographolide 7, and two acids, cinnamic acid 8, and ferulic acid 9. The chemical structures were established by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-ESI MS analyses. The methanolic extract of the leaves exhibited moderate antibacterial and antifungal activities at a dose of 200 microg/mL in comparison with the reference standards.
authors.affiliation: Department of Biochemistry, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India. parvataneni_radhika@yahoo.com
authors.forename: Parvataneni
authors.initials: P
authors.lastname: Radhika
authors.forename: Yejella Rajendra
authors.initials: YR
authors.lastname: Prasad
authors.forename: Kattupalli
authors.initials: K
authors.lastname: Sowjanya
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: C572482:21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide; D004224:Diterpenes