title: Right ventricular dysfunction and dilatation in patients with mitral regurgitation: analysis using ECG-gated multidetector row computed tomography.
abstract: BACKGROUND
  This study prospectively compared the accuracy of a sixty-four slice multidetector row CT (64-MDCT) in cardiac magnetic resonance imaging (MRI) for the assessment of right ventricular (RV) dysfunction and dilatation in patients with mitral regurgitation.
  
  
  METHODS
  Eighty-four patients underwent ECG-gated 64-MDCT for the assessment of RV dysfunction and dilatation; 54 of these patients had known mitral regurgitation. End-diastolic and end-systolic volumes, stroke volume, and ejection fraction were measured using the 64-MDCT, and these results were retrospectively compared to the results of MRI (reference standard). Agreement between the 64-MDCT and MRI results was investigated using linear regression and Bland-Altman analyses. Receiver operating characteristic analyses calculated the sensitivity and specificity of RV dilatation on 64-MDCT scans for the prediction of mitral regurgitation severity and dysfunction, respectively.
  
  
  RESULTS
  No significant differences in RV function parameters were calculated between 64-MDCT and MRI (r=0.87 to 0.94; all p<0.001). Good intertechnique agreement was obtained using linear regression and Bland-Altman analyses. ROC analyses revealed that RV enlargement (>33 mm) on 64-MDCT scans predicted the RV dysfunction of mitral regurgitation with a sensitivity of 92.9% and a specificity of 82.9%.
  
  
  CONCLUSIONS
  ECG-gated 64-MDCT accurately and reliably assessed RV function in patients with and without mitral regurgitation. Moreover, the presence of RV dilatation on the 64-MDCT scan assisted in the prediction of RV dysfunction and mitral regurgitation severity.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China.
authors.forename: Ying-kun
authors.initials: YK
authors.lastname: Guo
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Heng
authors.initials: H
authors.lastname: Shao
authors.forename: Wen
authors.initials: W
authors.lastname: Deng
authors.forename: Gang
authors.initials: G
authors.lastname: Ning
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology; D061330:Multidetector Computed Tomography / Q000379:methods*; D011446:Prospective Studies; D012189:Retrospective Studies; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult