title: Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography.
abstract: Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of subsurface FMT are demonstrated in phantom. In the in vivo study, the red fluorescent protein activities not only on the surface but in the interior tumor are tracked three-dimensionally during the antitumor treatment.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Jinping
authors.initials: J
authors.lastname: Song
authors.forename: Zhongquan
authors.initials: Z
authors.lastname: Dai
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Jianwen
authors.initials: J
authors.lastname: Luo
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
mesh_terms: D000465:Algorithms; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D016903:Drug Monitoring / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014054:Tomography / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin