title: Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias.
abstract: OBJECTIVE
  To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.
  
  
  METHODS
  A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy (FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications. Upper endoscopy using high definition white light, 2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination. Two patients used as controls had normal endoscopy and histological results. Prospectively, videos were watched blind from histological results by three trained FICE technique endoscopists.
  
  
  RESULTS
  The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined. Videos did not identify irregular vascular patterns using high definition white light endoscopy, while acid acetic-FICE combined visualised one in 86% of cases.
  
  
  CONCLUSIONS
  Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.
authors.affiliation: Gastroenterology and Endoscopy Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbone Paris Cité, 75014 Paris, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Camus
authors.forename: Romain
authors.initials: R
authors.lastname: Coriat
authors.forename: Sarah
authors.initials: S
authors.lastname: Leblanc
authors.forename: Catherine
authors.initials: C
authors.lastname: Brezault
authors.forename: Benoit
authors.initials: B
authors.lastname: Terris
authors.forename: Elise
authors.initials: E
authors.lastname: Pommaret
authors.forename: Marianne
authors.initials: M
authors.lastname: Gaudric
authors.forename: Ariane
authors.initials: A
authors.lastname: Chryssostalis
authors.forename: Frederic
authors.initials: F
authors.lastname: Prat
authors.forename: Stanislas
authors.initials: S
authors.lastname: Chaussade
mesh_terms: D019342:Acetic Acid; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000473:pathology; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D019342:Acetic Acid