title: [Pharmaceutical and formulation aspects of Petroselinum crispum extract].
abstract: Parsley (Petroselinum crispum L.) is a very popular spice and vegetable in Europe, it is widely spread and easy to grow. It's herb and fruits are known to be diuretic, smooth muscle relaxant and hepatoprotective. The most important identified active ingredients are flavonoids, cumarins and vitamin C. Apigenin and its glycosides are the main flavonoids in parsley, it can be found relatively large amounts in the leaves. The bioactive flavonoid apigenin has antiinflammatory, antioxidant and anticancer activities. The objectives of this study were the preparation and detemination of the apigenin content of the parsley extract and the formulation using inert pellets by layering the apigenin in fluid-bed process.
authors.affiliation: Semmelweis Egyetem Gyógyszerészeti Intézet, 1092 Budapest, Hogyes Endre u. 7.
authors.forename: Zsófia Edit
authors.initials: ZE
authors.lastname: Pápay
authors.forename: Annamária
authors.initials: A
authors.lastname: Kósa
authors.forename: Imre
authors.initials: I
authors.lastname: Boldizsár
authors.forename: Akos
authors.initials: A
authors.lastname: Ruszkai
authors.forename: Emese
authors.initials: E
authors.lastname: Balogh
authors.forename: Imre
authors.initials: I
authors.lastname: Klebovich
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D047310:Apigenin / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D001205:Ascorbic Acid / Q000302:isolation & purification; D002626:Chemistry, Pharmaceutical; D003374:Coumarins / Q000302:isolation & purification; D004343:Drug Implants; D006801:Humans; D028528:Petroselinum; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D003374:Coumarins; D004343:Drug Implants; D010936:Plant Extracts; D047310:Apigenin; D001205:Ascorbic Acid