title: Pertubation with lidocaine--a non-hormonal, long-term treatment of dysmenorrhea due to endometriosis.
abstract: The major symptoms of endometriosis are dysmenorrhea and infertility. Pertubations with lidocaine have been shown to reduce dysmenorrhea and have an enhancing effect on fertility. Different concentrations of lidocaine were evaluated in a randomized, double-blind study of pre-ovulatory pertubations with lidocaine solutions in women with dysmenorrhea. The patients had laparoscopically diagnosed endometriosis and normal fallopian tubes. Ninety pertubations were carried out without complications on 26 patients during up to six cycles. The effect was evaluated by means of questionnaires where a clinically significant reduction of dysmenorrhea was reported. Pertubation with lidocaine can be a non-hormonal treatment option for dysmenorrhea.
authors.affiliation: Department of Obstetrics and Gynaecology, SE 751 85 Uppsala, Sweden. Greta.Edelstam@akademiska.se
authors.forename: Greta
authors.initials: G
authors.lastname: Edelstam
authors.forename: Anette
authors.initials: A
authors.lastname: Sjösten
authors.forename: Barbara
authors.initials: B
authors.lastname: Jablonowska
authors.forename: Svante
authors.initials: S
authors.lastname: Kjellberg
authors.forename: Jack
authors.initials: J
authors.lastname: Spira
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000209:etiology; D004715:Endometriosis / Q000150:complications; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D014591:Uterine Diseases / Q000150:complications
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine