title: Feasibility of a novel radiofrequency signal analysis for in-vivo plaque characterization in humans: comparison of plaque components between patients with and without acute coronary syndrome.
abstract: BACKGROUND
  The iMAP™ is a novel intravascular ultrasound (IVUS)-based technology to classify coronary plaque into 4 components. The aim of this study was to evaluate the feasibility of iMAP™ technology by comparing plaque characteristics in patients with and without acute coronary syndrome (ACS and non-ACS).
  
  
  METHODS
  A total of 93 culprit lesions from 87 patients were analyzed using the iMAP™. Each plaque was classified into 4 components with a newly introduced parameter, confidence level (CL).
  
  
  RESULTS
  iMAP™ analysis of the minimal lumen cross-sectional area (MLA) revealed that ACS lesions had significantly larger lipidic and necrotic areas than non-ACS lesions. Multivariate analysis revealed that the lipidic area at the MLA was an iMAP™ factor independently associated with ACS lesions (odds ratio -1.5, p=0.04). Based on receiver operating characteristic analysis with 4 different CL ranges, the lipidic area at the MLA with 25%-100% CL had the largest area under the curve (0.756), suggesting that 25%-100% is the best CL range for identifying ACS culprit lesions.
  
  
  CONCLUSIONS
  The feasibility of the novel iMAP™ IVUS system was shown in discriminating culprit lesions in patients with and without ACS. Analyzing with a CL of 25%-100% may be the best option for discriminating lesions.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
authors.forename: Amane
authors.initials: A
authors.lastname: Kozuki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shinke
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Otake
authors.forename: Junya
authors.initials: J
authors.lastname: Shite
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawamori
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nagoshi
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Hariki
authors.forename: Takumi
authors.initials: T
authors.lastname: Inoue
authors.forename: Ryo
authors.initials: R
authors.lastname: Nishio
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D054058:Acute Coronary Syndrome / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional / Q000379:methods*