title: [The dinitrosyl-iron complexes with cysteine block the development of experimental endometriosis in rats].
abstract: It has been shown that the administration of 0,5 ml of 5 mM aqueous solution of dinitrosyl-iron complexes (DNIC) with cysteine alleviated the development of experimental endometriosis in rats induced by surgical way: the size of endometriomes decreased 1.85 times when the DNIC was added every day during 10 days. The effect was suggested to be due to cytotoxic action of NO molecules and nitrosonium ions (NO+) released from rapidly decomposed DNIC in animal organism on endometriome tissues.
authors.forename: E N
authors.initials: EN
authors.lastname: Burgova
authors.forename: N A
authors.initials: NA
authors.lastname: Tkachev
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000818:Animals; D003545:Cysteine / Q000008:administration & dosage* / Q000627:therapeutic use; D003560:Cysts / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D004578:Electron Spin Resonance Spectroscopy; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D007274:Injections, Intraperitoneal; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D009589:Nitrogen Oxides / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009589:Nitrogen Oxides; C504137:nitrosonium ion; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D003545:Cysteine