title: Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population.
abstract: BACKGROUND
  Sex differences in hypertension are not well known. The present study was undertaken to detect the association of nine lipid-related gene polymorphisms and blood pressure variation beween men and women in the Bai Ku Yao population.
  
  
  METHODS
  Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low-density lipoprotein receptor (LDL-R) AvaII, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 682 normotensives and 670 hypertensives.
  
  
  RESULTS
  The genotypic frequencies of LDL-R and SCARB1 in normotensives and ABCA-1, ACAT-1, LDL-R, LIPC, and MTHFR in hypertensives were different between males and females (P < 0.05-0.001). The genotypic frequencies of ABCA-1, ACAT-1, LDL-R, LIPC, MTHFR, PPARD, and SCARB1 in males and ABCA-1, LDL-R, LIPC, LIPG, and MTHFR in females were different between normotensives and hypertensives (P < 0.05-0.001). Systolic blood pressure (SBP) levels in male hypertensives were different among the LIPC, LIPG, PCSK9, and SCARB1 genotypes (P < 0.05-0.01); and diastolic blood pressure (DBP) levels were different among the ABCA-1, LDL-R, LIPC, LIPG, MTHFR, PCSK9, and PPARD genotypes (P < 0.05-0.001). SBP levels in female hypertensives were different among the LIPC, MTHFR, PCSK9, and PPARD genotypes (P < 0.05-0.01); and DBP levels were different among ABCA-1, ACAT-1, MTHFR, PCSK9, PPARD, and SCARB1 genotypes (P <0.05-0.001). The correlations between these polymorphisms and blood pressure levels were also observed.
  
  
  CONCLUSIONS
  Sex differences in blood pressure levels in this population may partly attribute to the differences in some lipid-related gene polymorphisms.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, People's Republic of China. yinruixing@yahoo.com.cn
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Wu
authors.forename: Wan-Ying
authors.initials: WY
authors.lastname: Liu
authors.forename: Dong-Feng
authors.initials: DF
authors.lastname: Wu
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Cao
authors.forename: Lin
authors.initials: L
authors.lastname: Miao
authors.forename: Lynn Htet
authors.initials: LH
authors.lastname: Htet Aung
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Xing-Jiang
authors.initials: XJ
authors.lastname: Long
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Shang-Ling
authors.initials: SL
authors.lastname: Pan
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008049:Lipase / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D047494:PPAR delta / Q000235:genetics; D011110:Polymorphism, Genetic; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics; D051122:Scavenger Receptors, Class B / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics; D012737:Sex Factors; D002785:Sterol O-Acyltransferase / Q000235:genetics
chemical_list: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; C504173:LIPC protein, human; D047494:PPAR delta; D011973:Receptors, LDL; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D002785:Sterol O-Acyltransferase; C493492:sterol O-acyltransferase 1; C410382:LIPG protein, human; D008049:Lipase; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases