title: Redox-sensitive polymeric nanoparticles for drug delivery.
abstract: Bioresponsive polymeric nanoparticles have been extensively pursued for the development of tumor-targeted drug delivery. A novel redox-sensitive biodegradable polymer with "trimethyl-locked" benzoquinone was synthesized for the preparation of paclitaxel-incorporated nanoparticles. The synthesized redox-sensitive nanoparticles released paclitaxel in response to chemically triggered reduction.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
authors.forename: Hanjoung
authors.initials: H
authors.lastname: Cho
authors.forename: Jungeun
authors.initials: J
authors.lastname: Bae
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Garripelli
authors.forename: Joel M
authors.initials: JM
authors.lastname: Anderson
authors.forename: Ho-Wook
authors.initials: HW
authors.lastname: Jun
authors.forename: Seongbong
authors.initials: S
authors.lastname: Jo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D016227:Benzoquinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D017239:Paclitaxel / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D011108:Polymers; D011092:Polyethylene Glycols; D017239:Paclitaxel