title: Carotid intima media thickness, brachial flow mediated dilation and previous history of gestational diabetes mellitus.
abstract: OBJECTIVE
  Gestational diabetes mellitus (GDM) is a common pregnancy condition with long-term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (CIMT) in women with previous GDM (pGDM).
  
  
  METHODS
  Women with and without pGDM with an average of 4 years following the indexed pregnancy, participated in this study. Serum levels of IL-6, hs-CRP, adiponectin, homocystein and other biomedical parameters were measured. The existence of early atherogenesis process was evaluated by measuring CIMT and FMD.
  
  
  RESULTS
  HOMA-IR and insulin were significantly higher in women with pGDM. Women with pGDM had slightly higher CIMT and significantly lower percent of brachial FMD. FMD and CIMT, adjusted for age and blood pressure, showed the same pattern. FMD showed no correlation with biochemical or inflammatory markers.
  
  
  CONCLUSIONS
  Follow-up of this group of women, who are at increased risk of cardiovascular disease, with FMD should be considered.
authors.affiliation: Endocrinology and Metabolism Research Center Radiology Department, Tehran University of Medical Sciences, Tehran, Iran. fakhrzad@tums.ac.ir
authors.forename: Hossein
authors.initials: H
authors.lastname: Fakhrzadeh
authors.forename: Sudabeh
authors.initials: S
authors.lastname: Alatab
authors.forename: Farshad
authors.initials: F
authors.lastname: Sharifi
authors.forename: Mojde
authors.initials: M
authors.lastname: Mirarefein
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Badamchizadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghaderpanahi
authors.forename: Amir Pejman
authors.initials: AP
authors.lastname: Hashemi Taheri
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology*; D001916:Brachial Artery / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000503:physiopathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D014664:Vasodilation