title: Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
abstract: Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China. w_lsheng@163.com
authors.forename: Lisheng
authors.initials: L
authors.lastname: Wang
authors.forename: Yejun
authors.initials: Y
authors.lastname: You
authors.forename: Songqing
authors.initials: S
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Liu
authors.forename: Buming
authors.initials: B
authors.lastname: Liu
authors.forename: Jinni
authors.initials: J
authors.lastname: Wang
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Mingsheng
authors.initials: M
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Liang
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011807:Quinolizines; D003078:Colchicine; D000093842:Matrines