title: Increased inflammatory response and imbalance in blood and urinary oxidant-antioxidant status in South Indian women with gestational hypertension and preeclampsia.
abstract: OBJECTIVE
  The objective of this study is to assess the association of blood and urinary oxidative stress parameters and inflammatory markers in women with gestational hypertension and preeclampsia.
  
  
  METHODS
  Malondialdehyde, protein bound sialic acid and C-reactive protein were estimated in serum and urine of pregnant women diagnosed with preeclampsia (n=30) and gestational hypertension (n=30) and the results were compared with 30 normal pregnant women.
  
  
  RESULTS
  Whole blood glutathione level was reduced, and malondialdehyde and C-reactive protein levels were significantly higher and correlated with each other in preeclampsia (p<0.05). Urinary malondialdehyde significantly correlated with urinary protein bound sialic acid in preeclampsia (r=0.412; p=0.02). Receiver operating curve analysis of serum protein bound sialic acid and serum malondialdehyde showed reasonable cutoff values for the differential diagnosis of preeclampsia.
  
  
  CONCLUSIONS
  Oxidative stress and inflammatory response are greater in women with preeclampsia in comparison to pregnant women with gestational hypertension and there is an association between oxidative stress and inflammatory response.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605 006, India.
authors.forename: M Sathish
authors.initials: MS
authors.lastname: Babu
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: S
authors.initials: S
authors.lastname: Habeebullah
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism / Q000652:urine; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D007194:India; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism / Q000652:urine; D019158:N-Acetylneuraminic Acid / Q000097:blood / Q000378:metabolism / Q000652:urine; D016877:Oxidants / Q000097:blood / Q000378:metabolism* / Q000652:urine; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D011247:Pregnancy; D012372:ROC Curve; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D008315:Malondialdehyde; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid