title: Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors.
abstract: A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety.
authors.affiliation: Bio-Organic Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Daejeon 305-600, Republic of Korea.
authors.forename: Jongkook
authors.initials: J
authors.lastname: Lee
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Han
authors.forename: Heejung
authors.initials: H
authors.lastname: Jung
authors.forename: Jeon
authors.initials: J
authors.lastname: Yang
authors.forename: Jie-Won
authors.initials: JW
authors.lastname: Choi
authors.forename: Chong Hack
authors.initials: CH
authors.lastname: Chae
authors.forename: Chi Hoon
authors.initials: CH
authors.lastname: Park
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kwangho
authors.initials: K
authors.lastname: Lee
authors.forename: Jae Du
authors.initials: JD
authors.lastname: Ha
authors.forename: Chong Ock
authors.initials: CO
authors.lastname: Lee
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Ryu
authors.forename: Hyoung Rae
authors.initials: HR
authors.lastname: Kim
authors.forename: Jong Sung
authors.initials: JS
authors.lastname: Koh
authors.forename: Sung Yun
authors.initials: SY
authors.lastname: Cho
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D006801:Humans; D008958:Models, Molecular; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D000631:Aminopyridines; D000970:Antineoplastic Agents; D001583:Benzoxazoles; C497970:FLT3 protein, human; D019859:Proto-Oncogene Proteins c-met; D051941:fms-Like Tyrosine Kinase 3