title: Why rethink the structure-function relationships regulating TCR behavior?
abstract: Although the generally accepted (Standard) Model of the TCR has powered the accumulation of a large body of crucial data, it is lacking because of the failure of its basic tenet that allele-specific recognition of MHC-encoded restricting elements can be derived by somatic selection on a random repertoire. The limitations of the Standard Model due to this tenet and a glimpse at what a competing model might look like add up to yield a surprising new view of the structure-function relationships of the TCR. A published experiment illustrating this is discussed.
authors.affiliation: Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, Tel: (858) 453-4100 Ext. 1351.
authors.forename: Melvin
authors.initials: M
authors.lastname: Cohn