title: Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice.
abstract: Dab1(scm) mutant mice, characterized by cell ectopias and degeneration in cerebellum, hippocampus, and neocortex, were compared to non-ataxic controls for different facets of grooming caused by brief water immersions, as well as some non-grooming behaviors. Dab1(scm) mutants were strongly affected in their quantitative functional parameters, exhibiting higher starting latencies before grooming relative to non-ataxic littermates of the A/A strain, fewer grooming bouts, and grooming components of shorter duration, with an unequal regional distribution targeting almost totally the rostral part (head washing and forelimb licking) of the animal. Only bouts of a single grooming element were preserved. The cephalocaudal order of grooming elements appeared less disorganized, mutant and control mice initiating the grooming with head washing and forelimb licking prior to licking posterior parts. However, mutants differed from controls in that all their bouts were incomplete but uninterrupted, although intergroup difference for percentage of the incorrect transitions was not significant. In contrast to grooming, Dab1(scm) mice ambulated for a longer time. During walking episodes, they exhibited more body scratching than controls, possibly to compensate for the lack of licking different body parts. In conjunction with studies with other ataxic mice, these results indicate that the cerebellar cortex affects grooming activity and is consequently involved in executing various components, but not in its sequential organization, which requires other brain regions such as cerebral cortices or basal ganglia.
authors.affiliation: Université de Lorraine, INSERM U954, and Service de Microscopie Electronique, Faculté de Médecine, 54500 Vandoeuvre-les-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Strazielle
authors.forename: A
authors.initials: A
authors.lastname: Lefevre
authors.forename: C
authors.initials: C
authors.lastname: Jacquelin
authors.forename: R
authors.initials: R
authors.lastname: Lalonde
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001259:Ataxia / Q000235:genetics* / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology; D002525:Cerebellar Cortex / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006120:Grooming / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics
chemical_list: C103773:Dab1 protein, mouse; D009419:Nerve Tissue Proteins