title: Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?
abstract: There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.
authors.affiliation: Torbay Hospital, Lawes Bridge, Torquay, TQ2 7AA, UK. matthew.cates@doctors.org.uk
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Cates
authors.forename: C John
authors.initials: CJ
authors.lastname: Dickinson
authors.forename: Emma C J
authors.initials: EC
authors.lastname: Hart
authors.forename: Julian F R
authors.initials: JF
authors.lastname: Paton
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000503:physiopathology*; D001933:Brain Stem / Q000098:blood supply* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D051381:Rats; D011918:Rats, Inbred SHR; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology*; D014711:Vertebral Artery / Q000503:physiopathology*