title: Association of age with fluorescence in situ hybridization abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients.
abstract: We utilized a cohort with a high frequency of young patients to explore the correlation between fluorescence in situ hybridization (FISH) detected chromosomal abnormalities (CA) and age in multiple myeloma (MM). One hundred and nineteen patients with MM were included in the analysis. The median age was 60 years, 51% of patients were female and 56% were Caucasian. Translocations involving the IGH gene on chromosome 14 were more likely to be detected in older (≥ 60 years) patients (32.8% vs. 15.5%, p = 0.03), particularly because of a higher frequency of t(4;14) (14.8% vs. 3.4%, p = 0.05). Myeloma cells from older patients were also three times more likely to have multiple CA. The presence of high-risk CA influenced survival in patients <60 but not in patients ≥ 60. Among standard-risk patients, survival was significantly superior for patients <60. No effect of age on survival was detected for high-risk patients.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Butler
authors.forename: Daynna J
authors.initials: DJ
authors.lastname: Wolff
authors.forename: Yubin
authors.initials: Y
authors.lastname: Kang
authors.forename: Robert K
authors.initials: RK
authors.lastname: Stuart
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Costa
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D016019:Survival Analysis; D014178:Translocation, Genetic; D055815:Young Adult
chemical_list: D007143:Immunoglobulin Heavy Chains