title: Tools of the trade: psychophysiological interactions and functional connectivity.
abstract: Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. joreilly@fmrib.ox.ac.uk
authors.forename: Jill X
authors.initials: JX
authors.lastname: O'Reilly
authors.forename: Mark W
authors.initials: MW
authors.lastname: Woolrich
authors.forename: Timothy E J
authors.initials: TE
authors.lastname: Behrens
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Smith
authors.forename: Heidi
authors.initials: H
authors.lastname: Johansen-Berg
mesh_terms: D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D011603:Psychophysiology; D013647:Task Performance and Analysis
chemical_list: D010100:Oxygen