title: Integrin triplets of marine sponges in human brain receptor heteromers.
abstract: Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several receptor heteromers of human brain. The obtained results strengthen our hypothesis that these triplets may "guide-and-clasp" receptor-receptor interactions.
authors.affiliation: Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia. sasha_tar@hotmail.com
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Tarakanov
authors.forename: Kjell G
authors.initials: KG
authors.lastname: Fuxe
authors.forename: Dasiel O
authors.initials: DO
authors.lastname: Borroto-Escuela
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D019143:Evolution, Molecular; D047231:Geodia / Q000235:genetics*; D006801:Humans; D016023:Integrins / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D043887:Receptor, Cholecystokinin B / Q000235:genetics; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics; D064529:Receptor, Metabotropic Glutamate 5; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D018080:Receptors, GABA-B / Q000235:genetics; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D016023:Integrins; D043887:Receptor, Cholecystokinin B; D064529:Receptor, Metabotropic Glutamate 5; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D018341:Receptors, Adrenergic, alpha-2; D011956:Receptors, Cell Surface; D018080:Receptors, GABA-B; D018094:Receptors, Metabotropic Glutamate; D044282:Receptor, Serotonin, 5-HT1A; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1