title: [Advance in study of vascular endothelial cell and smooth muscle cell co-culture system].
abstract: The interactions between endothelial cells (EC) and smooth muscle cells (SMC) contribute to vascular physiological functions and also cause the occurrence and development of different kinds of diseases. Currently, EC-SMC co-culture model is the best way to study the interactions between the two kinds of cells. This article summarizes existing EC-SMC co-culture models and their effects on the structure and functions of the two kinds of cells. Microscopically speaking, it provides a basis for in-depth studies on their interactions as well as a reference for the establishment of in vitro EC-SMC co-culture system that is closer to organic physiology or pathology state.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medicinal Sciences, Beijing 100700, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Weng
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Congxiao
authors.initials: C
authors.lastname: Ruan
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D018920:Coculture Techniques / Q000379:methods*; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000378:metabolism