title: Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection.
abstract: Computational fluid dynamics, which uses numeric methods and algorithms for the simulation of blood flow by solving the Navier-Stokes equations on computational meshes, is enhancing the understanding of disease progression in type III aortic dissections. To illustrate this, we examined the changes in patient-derived geometries of aortic dissections, which showed progressive false lumen aneurysmal dilatation (26% diameter increase) during follow-up. Total pressure was decreased by 29% during systole and by 34% during retrograde flow. At the site of the highest false lumen dilatation, the temporal average of total pressure decreased from 45 to 22 Pa, and maximal average wall shear stress decreased from 0.9 to 0.4 Pa. These first results in the study of disease progression of type III DeBakey aortic dissection with computational fluid dynamics are encouraging.
authors.affiliation: Methodist DeBakey Heart & Vascular Center, Houston, TX 77030, USA. ckarmonik@tmhs.org
authors.forename: Christof
authors.initials: C
authors.lastname: Karmonik
authors.forename: Sasan
authors.initials: S
authors.lastname: Partovi
authors.forename: Matthias
authors.initials: M
authors.lastname: Müller-Eschner
authors.forename: Jean
authors.initials: J
authors.lastname: Bismuth
authors.forename: Mark G
authors.initials: MG
authors.lastname: Davies
authors.forename: Dipan J
authors.initials: DJ
authors.lastname: Shah
authors.forename: Matthias
authors.initials: M
authors.lastname: Loebe
authors.forename: Dittmar
authors.initials: D
authors.lastname: Böckler
authors.forename: Alan B
authors.initials: AB
authors.lastname: Lumsden
authors.forename: Hendrik
authors.initials: H
authors.lastname: von Tengg-Kobligk
mesh_terms: D000465:Algorithms; D000784:Aortic Dissection / Q000503:physiopathology*; D001014:Aortic Aneurysm / Q000503:physiopathology*; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed