title: Genome-wide association studies: prospects and challenges for oral health.
abstract: The genomic era of biomedical research has given rise to the genome-wide association study (GWAS) approach, which attempts to discover novel genes affecting an outcome by testing a large number (i.e., hundreds of thousands to millions) of genetic variants for association. This article discusses the issues surrounding the GWAS approach with emphasis on the prospects and challenges relevant to the oral health research community.
authors.affiliation: Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St., A300 Crabtree Hall, Pittsburgh, PA 15260, USA. jrs51@pitt.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Shaffer
authors.forename: E
authors.initials: E
authors.lastname: Feingold
authors.forename: M L
authors.initials: ML
authors.lastname: Marazita
mesh_terms: D055106:Genome-Wide Association Study; D006801:Humans; D040582:Inheritance Patterns; D009909:Oral Health; D020641:Polymorphism, Single Nucleotide