title: Dependence of the excitability of pituitary cells on cyclic nucleotides.
abstract: Cyclic 3',5'-adenosine monophosphate and cyclic 3',5'-guanosine monophosphate are intracellular (second) messengers that are produced from the nucleotide triphosphates by a family of enzymes consisting of adenylyl and guanylyl cyclases. These enzymes are involved in a broad array of signal transduction pathways mediated by the cyclic nucleotide monophosphates and their kinases, which control multiple aspects of cell function through the phosphorylation of protein substrates. We review the findings and working hypotheses on the role of the cyclic nucleotides and their kinases in the control of electrical activity of the endocrine pituitary cells and the plasma membrane channels involved in this process.
authors.affiliation: Sections on Cellular Signalling and Endocrinology and Genetics, The Eunice Kennedy Shiver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Stojilkovic
authors.forename: K
authors.initials: K
authors.lastname: Kretschmannova
authors.forename: M
authors.initials: M
authors.lastname: Tomić
authors.forename: C A
authors.initials: CA
authors.lastname: Stratakis
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D055098:Endocrine Cells / Q000187:drug effects / Q000502:physiology*; D006162:Guanylate Cyclase / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D023421:Models, Animal; D008954:Models, Biological; D010902:Pituitary Gland / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D007473:Ion Channels; D047428:Protein Kinase Inhibitors; D005576:Colforsin; D000242:Cyclic AMP; D011494:Protein Kinases; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP