title: Increased levels of 8-hydroxy-2'-deoxyguanosine are attributable to organophosphate pesticide exposure among young children.
abstract: Oxidative damage has been proposed as an important mechanism linking pesticide exposure to health effects. A study of 268 young Shanghai children was conducted to examine the relationship between organophosphate pesticide (OP) exposure and a biomarker of oxidative DNA damage. Urine samples were analyzed for five nonspecific dialkyl phosphate (DAP) metabolites [dimethyl phosphates (DMs) and diethyl phosphates (DEs)] and 8-hydroxy-2'-deoxyguanosine (8-OHdG). The creatinine-adjusted median of 8-OHdG in urine samples was 3.99 ng/mg. Increased exposure to OPs was associated with greater levels of urinary 8-OHdG [total DAPs: ß (adjusted)=0.46 per log(10) unit increase, 95% confidence interval (CI)=0.40-0.53, p=0.000; DMs: ß (adjusted)=0.34, 95% CI=0.28-0.41, p=0.000; DEs: ß (adjusted)=0.48, 95% CI=0.42-0.54, p=0.000]. Thus, the 8-OHdG biomarker is useful for increasing our understanding of the link between childhood exposure to OPs and health outcomes.
authors.affiliation: MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Ding
authors.forename: Song
authors.initials: S
authors.lastname: Han
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Guoquan
authors.initials: G
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000652:urine; D002675:Child, Preschool; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity / Q000652:urine*; D018384:Oxidative Stress; D010575:Pesticides / Q000633:toxicity / Q000652:urine*
chemical_list: D015415:Biomarkers; D009943:Organophosphorus Compounds; D010575:Pesticides; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine