title: A rare case of primary hyperparathyroidism associated with primary aldosteronism, Hürthle cell thyroid cancer and meningioma.
abstract: Multiple endocrine neoplasia type 1 (MEN1) syndrome includes varying combinations of endocrine and non-endocrine tumors. There are also a considerable number of atypical MEN1 syndrome. In this case, a 68-yr-old woman was referred to the Department of Endocrinology for hypercalcemia. Five years ago, she had diagnosed as primary hyperaldosteronism and now newly diagnosed as parathyroid hyperplasia with laboratory and pathologic findings. Hürthle-cell thyroid cancer was also resected during the parathyroid exploration and small meningioma was found on brain MRI. Her general condition has markedly improved and her adrenal mass and meningioma are being closely observed now. We could find the loss of heterozygosity of the MEN1 locus in parathyroid glands, suggesting a MEN1-related tumor, but not a germline mutation. Considering a variety of phenotypic expression and a limitation of current molecular analysis, periodic follow up will be needed in patients with a MEN1-like phenotype.
authors.affiliation: Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
authors.forename: You Lim
authors.initials: YL
authors.lastname: Kim
authors.forename: Young Woo
authors.initials: YW
authors.lastname: Jang
authors.forename: Jin Taek
authors.initials: JT
authors.lastname: Kim
authors.forename: Su Ah
authors.initials: SA
authors.lastname: Sung
authors.forename: Tae Seok
authors.initials: TS
authors.lastname: Lee
authors.forename: Won Mi
authors.initials: WM
authors.lastname: Lee
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D018249:Adenoma, Oxyphilic; D000368:Aged; D001483:Base Sequence; D001921:Brain / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis*; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D019656:Loss of Heterozygosity; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008579:Meningioma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009154:Mutation; D010280:Parathyroid Glands / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D011877:Radionuclide Imaging; D017422:Sequence Analysis, DNA; D013964:Thyroid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins