title: Past decade study of snake venom L-amino acid oxidase.
abstract: As one of the major protein (enzyme) components of snake venom (SV), L-amino acid oxidase (LAAO) plays an important role in the toxicities and biological activities for SV. Accumulated researches in the past decade gradually revealed that SV-LAAOs induce platelet aggregation, cell apoptosis and cytotoxicity, and have anti-microbial, anti-leishmaniasis, anti-tumor and anti-HIV activity. Except for the enzymatic and structural characteristics of SV-LAAOs, the biological functions of SV-LAAOs and relevant action mechanisms are also summarized and discussed in the review. This work might provide useful inputs for future studies on SV-LAAOs.
authors.affiliation: Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Guo
authors.forename: Shuqing
authors.initials: S
authors.lastname: Liu
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Yao
authors.forename: Qiaoqiao
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ming-Zhong
authors.initials: MZ
authors.lastname: Sun
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D003029:Coagulants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D055808:Drug Discovery; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D050830:L-Amino Acid Oxidase / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011487:Protein Conformation; D030162:Reptilian Proteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D012910:Snake Venoms / Q000201:enzymology*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003029:Coagulants; D006023:Glycoproteins; D008667:Metalloproteins; D010975:Platelet Aggregation Inhibitors; D030162:Reptilian Proteins; D012910:Snake Venoms; D050830:L-Amino Acid Oxidase