title: In vitro biocompatibility testing of some synthetic polymers used for the achievement of nervous conduits.
abstract: Biocompatible synthetic polymers are largely used in the bio-medical domain, tissue engineering and in controlled release of medicines. Polymers can be used in the achievement of cardiac and vascular devices, mammary implants, eye lenses, surgical threads, nervous conduits, adhesives, blood substitutes, etc. Our study was axed on the development of cytotoxicity tests for 3 synthetic polymers, namely polyvinyl alcohol, polyethylene glycol and polyvinyl chloride. These tests targeted to determine the viability and morphology of cells (fibroblasts) that were in indirect contact with the studied polymers. Cell viability achieved for all the studied synthetic polymers allowed their frame in biocompatible material category. Cell morphology did not significantly change, thus accomplishing a new biocompatibility criterion. The degree of biocompatibility of the studied polymers varied. Polyvinyl alcohol presented the highest grade of biocompatibility and polyvinyl chloride placed itself at the lowest limit of biocompatibility. The results achieved allowed the selection of those polymers that (by enhancing their degrees of biocompatibility due to the association with various biopolymers) will be used in the development of new biocompatible materials, useful in nervous conduits manufacture.
authors.affiliation: Bagdasar Arseni Clinical Emergency Hospital, Bucharest, Romania. andamihai07@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Mihai
authors.forename: I P
authors.initials: IP
authors.lastname: Florescu
authors.forename: V
authors.initials: V
authors.lastname: Coroiu
authors.forename: A
authors.initials: A
authors.lastname: Oancea
authors.forename: M
authors.initials: M
authors.lastname: Lungu
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D009420:Nervous System / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D011143:Polyvinyl Chloride / Q000494:pharmacology; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011092:Polyethylene Glycols; D011143:Polyvinyl Chloride; D011142:Polyvinyl Alcohol