title: Oropheayunnol, an unusual 22,23-epoxy apotirucallane triterpenoid from Orophea yunnanensis.
abstract: A new apotirucallane-type triterpenoid with an unusual 22,23-epoxy group in the side chain, 22,23-epoxy-apotirucalla-14-ene-3alpha,7alpha,24alpha,25-tetraol (1), was isolated from the leaves and twigs of Orophea yunnanensis. The structure of 1 was established on the basis of HRESIMS, 1D, and 2D NMR spectroscopic methods. This is the first phytochemical study of Orophea yunnanensis, and the biogenetic origin of 1 was postulated. Compound 1 exhibited weak cytotoxicity in vitro against the growth of CNE1 nasopharyngeal carcinoma cell line with an IC50 value of 9.7 microg/mL.
authors.affiliation: School of Pharmaceutical Sciences, Sun-Yat sen University, Guangzhou city, China, 510006.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yan-Qiong
authors.initials: YQ
authors.lastname: Guo
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D004852:Epoxy Compounds; D014315:Triterpenes; C572483:oropheayunnol