title: [Migraine-induced kidney stones?].
abstract: A 42-year old woman was referred for a metabolic evaluation after two episodes of kidney stones. Her laboratory results revealed a normal anion-gap metabolic acidosis, a marked hypocitraturia (0,6 mmol/24h; norm 1,6-4,5) and a urinary pH of 7,0 confirming renal tubular acidosis (RTA). We identified topiramate, our patient's medication for migraine, as the cause of the RTA. Topiramate, a carboanhydrase inhibitor leads to RTA of a mixed (proximal and distal) type and thus significantly increases the risk for kidney stones.
authors.affiliation: Klinik für Nephrologie, Universitätsspital Zürich, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Gerber
authors.forename: R P
authors.initials: RP
authors.lastname: Wüthrich
authors.forename: N
authors.initials: N
authors.lastname: Mohebbi
mesh_terms: D000138:Acidosis / Q000175:diagnosis / Q000209:etiology; D000141:Acidosis, Renal Tubular / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D019343:Citric Acid / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced* / Q000175:diagnosis; D008881:Migraine Disorders / Q000188:drug therapy*; D056844:Renal Colic / Q000139:chemically induced / Q000175:diagnosis; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D019343:Citric Acid; D005632:Fructose