title: [BRAF mutation and papillary thyroid cancer].
abstract: OBJECTIVE
  To explore the association bewteen BRAF mutations and papillary thyroid cancer.
  
  
  METHODS
  BRAF gene mutations in 73 cases of papillary thyroid cancer and 16 cases of thyroid gland benign tumor were detected by PCR and sequencing technology.
  
  
  RESULTS
  We found 42 instances of BRAF mutations in 73 cases of thyroid cancer. However, no mutation was found in tissues from benign thyroid tumors. There were significant correlations between BRAF mutation and lymph node metastasis, and between BRAF mutation and the clinical stage of papillary thyroid cancer (P<0.05).
  
  
  CONCLUSIONS
  The mutation of BRAF is associated with the pathogenesis, lymph node metastasis, and clinical stage of papillary thyroid cancer.
authors.affiliation: Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. yiwenjun@csco.org.cn
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yi
authors.forename: Dewu
authors.initials: D
authors.lastname: Zhong
authors.forename: Qiongyan
authors.initials: Q
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics*; D055815:Young Adult
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf