title: Duloxetine in adults with ADHD: a randomized, placebo-controlled pilot study.
abstract: OBJECTIVE
  To assess the effect of duloxetine on ADHD in adults.
  
  
  METHODS
  In a 6-week double-blind trial, 30 adults with ADHD received placebo or duloxetine 60 mg daily. The Conners' Adult ADHD Rating Scale (CAARS) and the Clinical Global Impression Scales (CGI) were used to assess symptom severity and clinical improvement. The Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS) were used to measure the effect on anxiety and depressive symptoms.
  
  
  RESULTS
  The Duloxetine group showed lower score on CGI-Severity at Week 6 (3.00 vs. 4.07 for placebo, p < .001), greater improvement on CGI-Improvement (2.89 vs. 4.00 at Week 6, p < .001), and greater decreases on five of eight subscales of the CAARS. There was no treatment group effect on HDRS or HARS scores.
  
  
  CONCLUSIONS
  Duloxetine may be a therapeutic option for adults with ADHD, but further studies are required to replicate these findings in larger samples.
authors.affiliation: 1University of Montreal, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bilodeau
authors.forename: Tarek
authors.initials: T
authors.lastname: Simon
authors.forename: Miriam H
authors.initials: MH
authors.lastname: Beauchamp
authors.forename: Paul
authors.initials: P
authors.lastname: Lespérance
authors.forename: Simon
authors.initials: S
authors.lastname: Dubreucq
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Dorée
authors.forename: Smadar Valérie
authors.initials: SV
authors.lastname: Tourjman
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride