title: Arterial hypertension perpetuates alveolar bone loss.
abstract: Few studies have focused on the impact of hypertension on the progression of periodontitis (PD). The purpose of this study was to evaluate whether hypertension affects PD by enhancing bone loss even after the stimulus for PD induction is removed. Ligature-induced PD was created on the first mandibular molars of spontaneously hypertensive rats (SHR) and normotensive rats (Wistar Kyoto-WKY). The animals were assigned to non-ligated controls (C) and PD groups: WKY-C, WKY-PD, SHR-C, and SHR-PD. After 10 days, five animals of each group were killed and the ligatures of the other animals were removed. On the 21st day (11 days without PD induced), the remaining animals were killed. The jaws were defleshed and the amount of bone loss was measured. After 10 days, the PD groups showed more bone loss than its controls (P < .05); SHR-PD = 0.72 ± 0.05 mm, SHR-C = 0.39 ± 0.04 mm, WKY-PD = 0.75 ± 0.04 mm, and WKY-C = 0.56 ± 0.04 mm. The cumulative bone loss on day 21 (0.94 ± 0.13 mm) was significantly worse than on day 10 only in SHR-PD group (P < .05). The final bone loss differences between PD and C groups accounted for 102% (SHR) and 26% (WKY) increase in comparison with the initial control levels. Hypertension is associated with progressive alveolar bone loss even when the stimulus for PD induction is removed and it may be speculated that host condition perpetuates alveolar bone loss.
authors.affiliation: Department of Oral Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Janine Montenegro Toscano Moura
authors.initials: JM
authors.lastname: de Medeiros Vanderlei
authors.forename: Michel Reis
authors.initials: MR
authors.lastname: Messora
authors.forename: Patrícia Garani
authors.initials: PG
authors.lastname: Fernandes
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Novaes
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
authors.forename: Marcio Fernando
authors.initials: MF
authors.lastname: de Moraes Grisi
authors.forename: Sergio Luis
authors.initials: SL
authors.lastname: Scombatti de Souza
authors.forename: Raquel Fernanda
authors.initials: RF
authors.lastname: Gerlach
authors.forename: Cristina
authors.initials: C
authors.lastname: Antoniali
authors.forename: Mario
authors.initials: M
authors.lastname: Taba
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006973:Hypertension / Q000150:complications*; D008026:Ligation / Q000009:adverse effects; D008297:Male; D010518:Periodontitis / Q000209:etiology / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY