title: Protein folding by 'levels of separation': a hypothesis.
abstract: The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long-range interactions between the transition and native states. Long-range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of 'degrees of separation', that we term 'levels of separation'. It is based on the integration of network science and biochemistry.
authors.affiliation: Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, USA.
authors.forename: Lesley H
authors.initials: LH
authors.lastname: Greene
authors.forename: Terri M
authors.initials: TM
authors.lastname: Grant
mesh_terms: D000818:Animals; D001671:Biochemistry / Q000379:methods; D019295:Computational Biology / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D010940:Plant Proteins / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D049490:Systems Biology / Q000379:methods
chemical_list: D010455:Peptides; D010940:Plant Proteins; D011506:Proteins; C093336:chymotrypsin inhibitor 2