title: Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder.
abstract: Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using the Illumina Human CNV370-quad Bead Chip was utilized in the analysis of the 92 MDD patients in the first sample. In all, 11 non-intergenic single-nucleotide polymorphisms with uncorrected allelic P-value <0.0001 were selected for the subsequent association analyses in the second sample of 136 MDD patients. Difference in allele distribution between responders and nonresponders were found in the second-stage sample for rs365836 and rs201522 of the CUX1 gene (P=0.005 and 0.004, respectively). The allelic P-values for rs365836 and rs201522 in both samples combined were 0.0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD.
authors.affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Sasayama
authors.forename: A
authors.initials: A
authors.lastname: Hiraishi
authors.forename: M
authors.initials: M
authors.lastname: Tatsumi
authors.forename: K
authors.initials: K
authors.lastname: Kamijima
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: W
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: R
authors.initials: R
authors.lastname: Yoshimura
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D005260:Female; D055106:Genome-Wide Association Study; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012097:Repressor Proteins / Q000235:genetics*; D014157:Transcription Factors
chemical_list: D000928:Antidepressive Agents; C080632:CUX1 protein, human; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014157:Transcription Factors