title: CCR5 as a potential target in cancer therapy: inhibition or stimulation?
abstract: Extensive evidence implicates CCR5 and its ligands in the biology of tumors, although there is considerable controversy regarding the role of this chemokine receptor in cancer progression. The discrepancies between the pro- and anti-tumor effects of CCR5 might derive from its expression by cell types with opposing functions in tumor progression and the context in which tumors originate. We propose that CCR5 is necessary for optimal activation of the adaptive immune response to tumors, and for the success of certain immunotherapeutic strategies. Since efficient activation of T cell responses has broad implications in the success of some chemoand radiotherapy protocols, activation of CCR5, rather than its inhibition, might provide new therapeutic opportunities for cancer treatment.
authors.affiliation: The Scripps Research Institute, Department of Immunology and Microbial Science, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Alicia
authors.initials: A
authors.lastname: González-Martin
authors.forename: Emilia
authors.initials: E
authors.lastname: Mira
authors.forename: Santos
authors.initials: S
authors.lastname: Mañes
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D018925:Chemokines / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D019713:Receptors, CCR5 / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D018925:Chemokines; D007155:Immunologic Factors; D019713:Receptors, CCR5