title: Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery.
abstract: OBJECTIVE
  To evalaute the effect of fixed-combination latanoprost 0.005%/timolol maleate 0.5% and dorzolamide hydrochloride 2%/timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery.
  
  
  METHODS
  This study is a prospective, randomized, double-masked and placebo-controlled. The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery. Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients). Two hour before surgery, the patients received one drop latanoprost/timolol (group 1), dorzolamide/timolol (group 2) and placebo (group 3, control group). The IOPs were measured at preoperative and postoperative 4, 8, and 24 hours.
  
  
  RESULTS
  The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group. In group 1 and 2, the postoperative mean IOP [group1: (14.03±3.15)mmHg and group 2: (14.16±4.43)mmHg] at 24 hours were significantly lower than the control group [(16.93±3.70)mmHg, (P<0.05)]. In addition, the postoperative mean IOP of group 1 [(14.90±3.69)mmHg] at 8 hours was significantly lower than the control group [(17.70±3.89)mmHg, (P<0.05)], but there was no significant difference between group 2 [(16.16±5.23)mmHg] and control group at 8 hours (P>0.05).
  
  
  CONCLUSIONS
  When compared with placebo, the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery, but did not completely prevent IOP spikes.
authors.affiliation: Departments of Ophthalmology, School of Medicine, University of Cumhuriyet, Sivas-Turkey.
authors.forename: Haydar
authors.initials: H
authors.lastname: Erdogan
authors.forename: Ayse Vural
authors.initials: AV
authors.lastname: Ozec
authors.forename: Cengiz
authors.initials: C
authors.lastname: Caner
authors.forename: Mustafa Ilker
authors.initials: MI
authors.lastname: Toker
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Arici
authors.forename: Aysen
authors.initials: A
authors.lastname: Topalkara