title: Fluctuations and micro-heterogeneity in aqueous mixtures.
abstract: The problem as to why water-water density correlations are systematically overestimated in computer simulation of aqueous mixtures is examined through an extensive molecular dynamics study of mixtures of the extended single point charge water model with a fully miscible weaker version of it, obtained by scaling down the site partial charges by a factor 2/3, thereby eliminating solute-solvent size differences. The study reveals that enhanced water correlations is a genuine physical effect, and are not an artifact of the simulations or the models, as previously suggested in the context of realistic aqueous mixtures. Rather, they correspond to the existence of strongly correlated water domains, for "weak-water" mole fraction x > 0.4, that modulate the spatial decay of the density correlations. These domains produce a prepeak in the structure factor, suggesting that simple aqueous mixture might behave just like micro-emulsions. The overestimated long range water correlations result from incorrect predictions of the asymptote of these correlations, which themselves arise from size limitations of the simulation box. However, by requiring consistency between thermodynamical and structural expressions of the concentration fluctuations, a method to predict the proper decay of the correlation function is obtained herein, inspired by the formal analogy with micro-emulsions. This study provides a new insight for the large values of the experimental Kirkwood-Buff integrals for many aqueous mixtures: these mixtures are in a Lifshitz-type regime, where concentration fluctuations compete with water domain formation.
authors.affiliation: Laboratoire de Physique Théorique de la Matière Condensée, Université Pierre et Marie CURIE, 4 Place Jussieu, F75252 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Perera
authors.forename: R
authors.initials: R
authors.lastname: Mazighi
authors.forename: B
authors.initials: B
authors.lastname: Kežić