title: The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
abstract: Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.
authors.affiliation: Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA. bfarese@gladstone.ucsf.edu
authors.forename: Robert V
authors.initials: RV
authors.lastname: Farese
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zechner
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Newgard
authors.forename: Tobias C
authors.initials: TC
authors.lastname: Walther
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D051379:Mice
chemical_list: D007328:Insulin