title: Synthesis and antimicrobial activities of structurally novel S,S'-bis(heterosubstituted) disulfides.
abstract: The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillin-resistant S. aureus and F. tularensis.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
authors.forename: Praveen
authors.initials: P
authors.lastname: Ramaraju
authors.forename: Danielle
authors.initials: D
authors.lastname: Gergeres
authors.forename: Edward
authors.initials: E
authors.lastname: Turos
authors.forename: Sonja
authors.initials: S
authors.lastname: Dickey
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Lim
authors.forename: John
authors.initials: J
authors.lastname: Thomas
authors.forename: Burt
authors.initials: B
authors.lastname: Anderson
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005604:Francisella tularensis / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D004220:Disulfides