title: Hypothetical two-step initiation of experimental carcinogenesis by polycyclic aromatic hydrocarbons and aminoazo dyes.
abstract: A new hypothesis is discussed, which describes the initiation of the carcinogenesis through polycyclic aromatic hydrocarbons (PAHs) and aminoazo dyes (AZOs) as a two-step process: the oncogenic proteins of the ras or ras-like on-cogenes activated by mutation ("initiation A ") co-operate with the complexes in the plasma membrane formed during the "initiation B " stage from the parent compounds of the PAHs or AZOs with cholesterol and apolipoprotein A-I. The final result of this co-operation, or the "complete initiation", is an irreversibly modified membrane architecture with negative consequences for growth control.
authors.affiliation: Beuth Hochschule für Technik Berlin; Fachbereich II; Pharma- und Chemietechnik Luxemburger Str. 10; 13353 Berlin, Germany.
authors.forename: Bodo
authors.initials: B
authors.lastname: Contag