title: Glucose administration attenuates spatial memory deficits induced by chronic low-power-density microwave exposure.
abstract: Extensive evidence indicates that glucose administration attenuates memory deficits in rodents and humans, and cognitive impairment has been associated with reduced glucose metabolism and uptake in certain brain regions including the hippocampus. In the present study, we investigated whether glucose treatment attenuated memory deficits caused by chronic low-power-density microwave (MW) exposure, and the effect of MW exposure on hippocampal glucose uptake. We exposed Wistar rats to 2.45 GHz pulsed MW irradiation at a power density of 1 mW/cm(2) for 3 h/day, for up to 30 days. MW exposure induced spatial learning and memory impairments in rats. Hippocampal glucose uptake was also reduced by MW exposure in the absence or presence of insulin, but the levels of blood glucose and insulin were not affected. However, these spatial memory deficits were reversed by systemic glucose treatment. Our results indicate that glucose administration attenuates the spatial memory deficits induced by chronic low-power-density MW exposure, and reduced hippocampal glucose uptake may be associated with cognitive impairment caused by MW exposure.
authors.affiliation: Department of Occupational Health, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Lu
authors.forename: Shangcheng
authors.initials: S
authors.lastname: Xu
authors.forename: Mindi
authors.initials: M
authors.lastname: He
authors.forename: Chunhai
authors.initials: C
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Chu
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Yu
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000528:radiation effects; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000528:radiation effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D008872:Microwaves / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000528:radiation effects; D013549:Sweetening Agents / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013549:Sweetening Agents; D005947:Glucose