title: SGK3 is associated with estrogen receptor expression in breast cancer.
abstract: While breast cancer mortality rate has seen a steady decline in the last few decades, advances in better treatment and diagnostic tools remain important as we come into the age of personalized therapy. In this report, we describe our studies of SGK3's role in breast cancer. SGK3 (also known as CISK) is a member of the AGC family of kinases. Our previous work indicates that SGK3 functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with Akt. Here, we show that SGK3 expression is linked to estrogen receptor (ER) both in breast caner cell lines and in primary tumor samples. Our analysis also indicated a positive correlation between SGK3 expression and tumor prognosis. Importantly, our immunochemistry analysis of human tumor samples established a clinical link between SGK3 expression and ER+ tumors. These findings implicate SGK3 as an additional component to a complex and heterogeneous disease, and point to the potential benefits of incorporating SGK3 into the process of breast cancer diagnosis and treatment.
authors.affiliation: Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Ma
authors.initials: M
authors.lastname: Wan
authors.forename: Quanyuan
authors.initials: Q
authors.lastname: He
authors.forename: Roland L
authors.initials: RL
authors.lastname: Bassett
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Fu
authors.forename: Albert C
authors.initials: AC
authors.lastname: Chen
authors.forename: Fengtao
authors.initials: F
authors.lastname: Shi
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Creighton
authors.forename: Rachel
authors.initials: R
authors.lastname: Schiff
authors.forename: Lei
authors.initials: L
authors.lastname: Huo
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D017346:Protein Serine-Threonine Kinases; D011960:Receptors, Estrogen; C403243:SGK3 protein, human; D000099184:Serum-Glucocorticoid Regulated Kinases