title: Mutual exclusion of transcription factors and cell behaviour in the definition of vertebrate embryonic territories.
abstract: Early embryonic territories are transient entities under permanent remodelling to form newly derived cell populations that will eventually give rise to the adult tissues and organs. A vast effort has been devoted to identifying the determinants and mechanisms that define embryonic territories. Indeed, studies in the vertebrate embryo from the morula stage to the segregation of the main embryonic layers-ectoderm, mesoderm and endoderm-have highlighted the importance of the mutual exclusion/repression between pairs of transcription factors, in coordination with the control exerted over cell division, adhesion and motility.
authors.affiliation: Instituto de Neurociencias CSIC-UMH, Avda Ramón y Cajal s/n, San Juan de Alicante, 03550, Spain; UMR 444, INRA-ENVT, Génétique Cellulaire, Toulouse, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Acloque
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Ocaña
authors.forename: M Angela
authors.initials: MA
authors.lastname: Nieto
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D016764:Cell Polarity; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*; D014714:Vertebrates / Q000196:embryology* / Q000378:metabolism*
chemical_list: D014157:Transcription Factors