title: Control of in vivo blood clearance time of polymeric micelle by stereochemistry of amphiphilic polydepsipeptides.
abstract: Polymeric micelle, "Lactosome", is composed of amphiphilic polydepsipeptide with a hydrophobic block of helical poly(L-lactic acid) (PLLA) and a hydrophilic block of poly(sarcosine). Lactosome was labeled by incorporation of poly(lactic acid) having a near-infrared fluorescence (NIRF) chromophore, and studied on blood clearance and tumor imaging. In vivo blood clearance time of Lactosome was prolonged with incorporation of poly(D-lactic acid) (PDLA), but decreased with poly(D,L-lactic acid) (PDLLA). NIRF imaging with applying these Lactosomes to tumor-bearing mice revealed that the tumor/background intensity ratio increased with incorporation of PDLLA. Stereochemistry in the hydrophobic core of self-assemblies is thus an important factor for determining physical stability in the blood stream and consequently contrast in imaging.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Makino
authors.forename: Eri
authors.initials: E
authors.lastname: Hara
authors.forename: Isao
authors.initials: I
authors.lastname: Hara
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamahara
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kurihara
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ozeki
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yamamoto
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Kimura
mesh_terms: D000818:Animals; D002460:Cell Line; D047630:Depsipeptides / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D019344:Lactic Acid / Q000008:administration & dosage / Q000097:blood* / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D009369:Neoplasms / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000097:blood* / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D012521:Sarcosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D047630:Depsipeptides; D005456:Fluorescent Dyes; D008823:Micelles; D010455:Peptides; D011091:Polyesters; D011108:Polymers; C015475:polysarcosine; D019344:Lactic Acid; C033616:poly(lactide); D007208:Indocyanine Green; D012521:Sarcosine