title: An outbreak of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
abstract: We present a large outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit that resulted in 31 colonized infants, 10 invasive infections, and 5 attributable deaths over a 5-month period. Although the source of infection was unknown, overcrowding and understaffing appeared to have been aggravating factors.
authors.affiliation: Johns Hopkins Medical Institutions, Division of Pediatric Infectious Diseases, Baltimore, MD 21287, USA. ptamma1@jhmi.edu
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.forename: Patrice
authors.initials: P
authors.lastname: Savard
authors.forename: Tibor
authors.initials: T
authors.lastname: Pál
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Sonnevend
authors.forename: Trish M
authors.initials: TM
authors.lastname: Perl
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Milstone
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D017053:Infection Control; D007363:Intensive Care Units, Neonatal; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D001618:beta-Lactamases