title: Latent class analysis of early developmental trajectory in baby siblings of children with autism.
abstract: BACKGROUND
  Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used.
  
  
  METHODS
  Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification.
  
  
  RESULTS
  A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4.
  
  
  CONCLUSIONS
  Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A.
authors.affiliation: Center for Autism and Related Disorders, Kennedy Krieger Institute, Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA. landa@kennedykrieger.org
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Landa
authors.forename: Alden L
authors.initials: AL
authors.lastname: Gross
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stuart
authors.forename: Margaret
authors.initials: M
authors.lastname: Bauman
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008960:Models, Psychological; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D035781:Siblings / Q000523:psychology*