title: Laparoscopic radical prostatectomy: Oncological outcome analysis from a single-center Indian experience of 6 years.
abstract: BACKGROUND
  There is a lack of published data on laparoscopic radical prostatectomy (LRP) in India. Although the published short-term oncologic outcomes after LRP are encouraging, intermediate and long-term data are lacking.
  
  
  OBJECTIVE
  We analyzed the oncological outcome after LRP based on 6 years of experience and compared it with the other single-center published literature.
  
  
  METHODS
  Of the 90 patients who underwent LRP for a clinical T2 localized disease, 73 patients with at least a follow up of one year were analyzed. Patients were classified as low-, intermediate-, and high-risk D'Amico groups in 22 (30%), 26 (36%), and 25 (34%) of the patient population, respectively. Progression of disease was defined as a PSA of 0.4ng/ml with a confirmatory rise. We used Kaplan-Meier product limit estimates to calculate actuarial 5-year probabilities of biochemical progression-free survival. Univariate analysis of risk factors for biochemical recurrence (BCR) was done.
  
  
  RESULTS
  The mean age of the patients was 63.3 ± 6.6 years. The average follow-up for patients was 22 (12-72) months. There was no prostatic cancer-specific mortality. Fourteen patients had BCR. The 5-year progression-free probability for men with low-, intermediate-, and high-risk prostate cancers was 91%, 82%, and 58%, respectively. High-risk group, Gleason sum more than 8, extracapsular extension, and positive surgical margin were significantly associated with biochemical progression.
  
  
  CONCLUSIONS
  LRP provided a similar level of oncological success as reported by the other contemporary single-center published literature.
authors.affiliation: Department of Urology, Muljibhai Patel Urological Hospital, Nadaid, Gujarat, India.
authors.forename: Shashikant
authors.initials: S
authors.lastname: Mishra
authors.forename: Vikas
authors.initials: V
authors.lastname: Agrawal
authors.forename: Naushad
authors.initials: N
authors.lastname: Khatri
authors.forename: Rajan
authors.initials: R
authors.lastname: Sharma
authors.forename: Abraham
authors.initials: A
authors.lastname: Kurien
authors.forename: Arvind
authors.initials: A
authors.lastname: Ganpule
authors.forename: V
authors.initials: V
authors.lastname: Muthu
authors.forename: Ravindra B
authors.initials: RB
authors.lastname: Sabnis
authors.forename: Mahesh R
authors.initials: MR
authors.lastname: Desai