title: Single-molecular artificial transmembrane water channels.
abstract: Hydrazide-appended pillar[5]arene derivatives have been synthesized. X-ray crystal structure analysis and (1)H NMR studies revealed that the molecules adopt unique tubular conformations. Inserting the molecules into the lipid membranes of vesicles leads to the transport of water through the channels produced by single molecules, as supported by dynamic light scattering and cryo-SEM experiments. The channels exhibit the transport activity at a very low channel to lipid ratio (0.027 mol %), and a water permeability of 8.6 × 10(-10) cm s(-1) is realized. In addition, like natural water channel proteins, the artificial systems also block the transport of protons.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Hu
authors.forename: Zhenxia
authors.initials: Z
authors.lastname: Chen
authors.forename: Gangfeng
authors.initials: G
authors.lastname: Tang
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Hou
authors.forename: Zhan-Ting
authors.initials: ZT
authors.lastname: Li
mesh_terms: D020346:Aquaporins / Q000737:chemistry* / Q000378:metabolism; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D047250:Calixarenes; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010539:Permeability; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000378:metabolism; D014867:Water / Q000378:metabolism*
chemical_list: D020346:Aquaporins; D006834:Hydrazines; D008081:Liposomes; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; C029424:hydrazine