title: Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.
abstract: As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol(3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines.
authors.affiliation: University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, PO Box 26170, Greensboro, NC 27402, United States.
authors.forename: Sloan
authors.initials: S
authors.lastname: Ayers
authors.forename: Brandie M
authors.initials: BM
authors.lastname: Ehrmann
authors.forename: Audrey F
authors.initials: AF
authors.lastname: Adcock
authors.forename: David J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: Mansukh C
authors.initials: MC
authors.lastname: Wani
authors.forename: Cedric J
authors.initials: CJ
authors.lastname: Pearce
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Oberlies