title: Fox-Fordyce disease: response to adapalene 0.1%.
abstract: The Fox-Fordyce disease is a rare inflammatory dermatosis that affects mainly young women and is characterized by multiple follicular papules, skin color or brownish, very itchy, localized in areas rich in apocrine glands. Histopathology shows focal spongiosis of the upper infundibulum with fibrosis and perifollicular lymphohistiocytic infiltrate. The diagnosis is based on clinical and histopathological examination. Many treatment options have been described; however none of them is excellent. We chose the topic adapalene 0.1% and a satisfactory improvement of the signs and symptoms of the disease was observed.
authors.affiliation: Dermatology Service of the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil. luizakassuga@yahoo.com.br
authors.forename: Luiza Erthal de Britto Pereira
authors.initials: LE
authors.lastname: Kassuga
authors.forename: Mariana Malta
authors.initials: MM
authors.lastname: Medrado
authors.forename: Natalia Stroligo
authors.initials: NS
authors.lastname: Chevrand
authors.forename: Simone de Abreu Neves
authors.initials: Sde A
authors.lastname: Salles
authors.forename: Enoï Guedes
authors.initials: EG
authors.lastname: Vilar
mesh_terms: D000068816:Adapalene; D002648:Child; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D005588:Fox-Fordyce Disease / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009281:Naphthalenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D009281:Naphthalenes; D000068816:Adapalene