title: The preterm infant with thrombosis.
abstract: In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.
authors.affiliation: Hematology/Oncology/Stem cell transplant, Children's Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA. rbhat@childrensmemorial.org
authors.forename: Rukhmi
authors.initials: R
authors.lastname: Bhat
authors.forename: Paul
authors.initials: P
authors.lastname: Monagle
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D019468:Disease Management; D005260:Female; D006487:Hemostasis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D012307:Risk Factors; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D000925:Anticoagulants