title: [Morphofunctional and molecular bases of pineal gland aging].
abstract: The review analyzed morphology, molecular and functional aspects of pineal gland aging and methods of it correction. The pineal gland is central organ, which regulates activity of neuroimmunoendocrine, antioxidant and other organisms systems. Functional activity of pineal gland is discreased at aging, which is the reason of melatonin level changing. The molecular and morphology research demonstrated, that pineal gland hadn't strongly pronounced atrophy at aging. Long-term experience showed, that peptides extract of pineal gland epithalamin and synthetic tetrapeptide on it base epithalon restored melatonin secretion in pineal gland and had strong regulatory activity at neuroimmunoendocrine and antioxidant organism systems.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008550:Melatonin / Q000378:metabolism* / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism / Q000502:physiology; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D019394:Ki-67 Antigen; D009842:Oligopeptides; D010455:Peptides; C027437:epithalamin; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D015740:Calcitonin Gene-Related Peptide; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine