title: The immunogenicity and safety of DTaP interchangeable immunization among Korean children.
abstract: Since the production of various vaccine formulations by different pharmaceutical companies and interruptions in vaccine supply cannot be fully regulated, problems caused by DTaP interchangeability may occur. However, the interchangeability data on the first primary series of DTaP vaccination have not been well described. In this study we investigated immunogenicity and overall safety of diphtheria, tetanus, pertussis in children who had adventitiously received an interchangeable DTaP vaccination. A total 97 of participants were enrolled (mean age, 11 months). High immunogenicity (1.8 ± 0.4 IU/mL, 100%) was noted against diphtheria toxoid, and similar high immunogenicity (3.2 ± 2.1 IU/mL, 100%) was noted against tetanus toxoid. Immunogenicity against pertussis antigen was significantly greater in the interchangeable vaccinated group compared to the control group, and 57% of the interchangeable vaccinated subjects achieved high levels of protective immunity (45.2 ± 21.5 E U/mL). No serious adverse effects were noted, and most adverse effects resolved without treatment. The immunogenicity against each antigen was high in patients who were interchangeably vaccinated for DTaP. Our results provide clinical evidence affirming the non-inferiority of interchangeable vaccination when it cannot be avoided such as in limited vaccine supply situations or different prices.
authors.affiliation: Department of Pediatrics, College of Medicine, The Catholic University, Seoul, Republic of Korea.
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Kwak
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hwang Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Park
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Ma
authors.forename: Jun Gyou
authors.initials: JG
authors.lastname: Kim
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D004165:Diphtheria / Q000517:prevention & control; D004167:Diphtheria Toxin / Q000276:immunology; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D006801:Humans; D007114:Immunization / Q000379:methods*; D007223:Infant; D008297:Male; D056910:Republic of Korea; D013742:Tetanus / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000276:immunology; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D004167:Diphtheria Toxin; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D013745:Tetanus Toxoid; D010566:Virulence Factors, Bordetella; C068929:pertactin