title: [Regulation of endothelial cells functions by ultrasonic supernatant of Streptococcus pyogenes].
abstract: Angiogenesis and vascular remodeling are vital components of inflammation. As an inflammation evolves, vessels expand to supply nutrients and inflammatory mediators, sustaining the accumulation of activated immune cells in the affected tissues. This study demonstrates that ultrasonic supernatant of Streptoccocus pyogenes has anti-angiogenic properties: inhibit EA.hy 926 human endothelial cells metabolism, adhesion, migration, proliferation. At the same time Streptococcal components inhibit signaling pathways that involve FAK and ERK1/2. These effects are not associated with necrosis or apoptosis in cell culture. Taking together, our results suggest that impairing angiogenic function of endothelial cells might contribute to the reduced tissue perfusion, hypoxia, and subsequent regional tissue necrosis caused by Streptococci group A.
authors.forename: É A
authors.initials: ÉA
authors.lastname: Starikova
authors.forename: A M
authors.initials: AM
authors.lastname: Lebedeva
authors.forename: L A
authors.initials: LA
authors.lastname: Burova
authors.forename: I S
authors.initials: IS
authors.lastname: Freĭdlin
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002498:Centrifugation; D045424:Complex Mixtures / Q000494:pharmacology*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005434:Flow Cytometry; D051417:Focal Adhesion Kinase 1 / Q000235:genetics; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013010:Sonication; D013297:Streptococcus pyogenes / Q000737:chemistry*
chemical_list: D045424:Complex Mixtures; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3