title: [Congestive heart failure: reverse cardiac remodeling mediated by left ventricular assist devices].
abstract: Left ventricular assist devices (LVAD) are currently used to treat patients with terminal congestive heart failure as a bridge to transplantation or as destination therapy in individuals with contraindications for cardiac transplantation. The LVADs are pulsatile or non-pulsatile systems that transport blood from the left ventricle to the ascending aorta parallel to the circulation thus providing a profound volume and pressure reduction in the left ventricle. The use of LVADs is associated with a considerable decrease of cardiac hypertrophy and dilation with significantly improved cardiac performance in a small subset of patients. The underlying process is termed reverse cardiac remodelling and is characterized by a significant decrease in the size of cardiomyocytes and reversible regulation of numerous molecular systems in the myocardium.
authors.affiliation: Institut für Pathologie und Neuropathologie, Universitätsklinik Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Deutschland. jeremias.wohlschlaeger@uk-essen.de
authors.forename: J
authors.initials: J
authors.lastname: Wohlschläger
authors.forename: H
authors.initials: H
authors.lastname: Milting
authors.forename: J
authors.initials: J
authors.lastname: Stypmann
authors.forename: T
authors.initials: T
authors.lastname: Hager
authors.forename: C
authors.initials: C
authors.lastname: Schmid
authors.forename: B
authors.initials: B
authors.lastname: Levkau
authors.forename: H A
authors.initials: HA
authors.lastname: Baba
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D048429:Cell Size; D004261:DNA Replication / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006333:Heart Failure / Q000473:pathology* / Q000628:therapy*; D006353:Heart-Assist Devices; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology; D045265:Natriuretic Peptides / Q000502:physiology; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000473:pathology; D025801:Ubiquitin / Q000502:physiology
chemical_list: D018836:Inflammation Mediators; D045265:Natriuretic Peptides; D011943:Receptors, Adrenergic, beta; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex