title: Zeolitic Imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle.
abstract: Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.
authors.affiliation: Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education Department of Chemistry, Northeast Normal University, Changchun, 130024, China.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Sun
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.forename: Xin-Long
authors.initials: XL
authors.lastname: Wang
authors.forename: Guang-Sheng
authors.initials: GS
authors.lastname: Yang
authors.forename: Kui-Zhan
authors.initials: KZ
authors.lastname: Shao
authors.forename: Ya-Qian
authors.initials: YQ
authors.lastname: Lan
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Su
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Chun-Gang
authors.initials: CG
authors.lastname: Wang
authors.forename: En-Bo
authors.initials: EB
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D017641:Zeolites / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D007093:Imidazoles; D017641:Zeolites; C029899:imidazole; D005472:Fluorouracil