title: Vaccine-derived human-bovine double reassortant rotavirus in infants with acute gastroenteritis.
abstract: We describe 3 cases of acute gastroenteritis in healthy infants after vaccination with RotaTeq, shedding a G1P[8] human-bovine double reassortant rotavirus in stools. Such a double reassortant virus appears stable in vitro and may explain diarrheal symptoms in a small percentage of RotaTeq recipients, and might also be transmitted to contacts in the environment.
authors.affiliation: Vaccine Research Center, University of Tampere School of Medicine, Tampere, Finland.
authors.forename: Maria
authors.initials: M
authors.lastname: Hemming
authors.forename: Timo
authors.initials: T
authors.lastname: Vesikari
mesh_terms: D000208:Acute Disease; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000175:diagnosis / Q000821:virology*; D022243:Rotavirus Vaccines / Q000009:adverse effects*; D014613:Vaccines, Attenuated / Q000009:adverse effects
chemical_list: C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated