title: [Soluble major histocompatibility complex class I-related chain A in sera of patients with oral squamous cell carcinoma].
abstract: OBJECTIVE
  To examine the expression of soluble major histocompatibility complex class I-related chain A (sMICA) in the serum in patients with oral squamous cell carcinoma (OSCC) and to explore its clinicopathological significance.
  
  
  METHODS
  Seventy-eight OSCC patients were selected as an experiment group, and 19 healthy persons as a control group. The sMICA in the serum in the experiment group and the control group was detected by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The detection rate of sMICA in the serum in the experiment group was 98.7% (77/78), with the 95% confidence interval 74.30-93.95 pg/mL and the median 82.17 pg/mL, The detection rate in the control group was 94.7% (18/19), with the 95% confidence interval 29.48-50.30 pg/mL and the median 37.54 pg/mL. The sMICA in the serum in the experiment group was higher than that in the control group (P<0.01). There was statistic difference in the serum sMICA in the experiment group among the different clinicopathological parameters such as tumor size, disease stage and regional lymph node status (P<0.05), but no difference was found in gender, age, and tumor differentiation (P>0.05).
  
  
  CONCLUSIONS
  The sMICA in the serum in the OSCC patients increases, and is related with the tumor size, disease stage and regional lymph node status. Determination of sMICA in the serum may provide useful information to evaluate the immune state of OSCC patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha,China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Shi
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Xinchun
authors.initials: X
authors.lastname: Jian
authors.forename: Canhua
authors.initials: C
authors.lastname: Jiang
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D012995:Solubility
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A