title: Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs.
abstract: BACKGROUND
  Mechanical ventilation (MV) can lead to ventilator-induced lung injury secondary to trauma and associated increases in pulmonary inflammatory cytokines. There is controversy regarding the associated systemic inflammatory response. In this report, we demonstrate the effects of MV on systemic inflammation.
  
  
  METHODS
  This report is part of a previously published study (Hong et al. Anesth Analg 2010;110:1652-60). Female pigs were randomized into 3 groups. Group H-Vt/3 was ventilated with a tidal volume (Vt) of 15 mL/kg predicted body weight (PBW)/positive end-expiratory pressure (PEEP) of 3 cm H(2)O; group L-Vt/3 with a Vt of 6 mL/kg PBW/PEEP of 3 cm H2O; and group L-Vt/10 with a Vt of 6 mL/kg PBW/PEEP of 10 cm H(2)O, for 8 hours. Each group had 6 subjects (n = 6). Prelung and postlung sera were analyzed for inflammatory markers. Hemodynamics, airway mechanics, and arterial blood gases were monitored.
  
  
  RESULTS
  There were no significant differences in systemic cytokines among groups. There were similar trends of serum inflammatory markers in all subjects. This is in contrast to findings previously published demonstrating increases in inflammatory mediators in bronchoalveolar lavage.
  
  
  CONCLUSIONS
  Systemic inflammatory markers did not correlate with lung injury associated with MV.
authors.affiliation: Department of Anesthesiology, University of Maryland, 22 S. Greene St., S11C, Baltimore, MD 21201, USA. chong@anes.umm.edu
authors.forename: Caron M
authors.initials: CM
authors.lastname: Hong
authors.forename: Da-Zhong
authors.initials: DZ
authors.lastname: Xu
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Cheng
authors.forename: Vadim
authors.initials: V
authors.lastname: Pisarenko
authors.forename: Danielle
authors.initials: D
authors.lastname: Doucet
authors.forename: Margaret
authors.initials: M
authors.lastname: Brown
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Zhang
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Deitch
authors.forename: Ellise
authors.initials: E
authors.lastname: Delphin
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D016207:Cytokines / Q000097:blood; D005260:Female; D006439:Hemodynamics; D018836:Inflammation Mediators / Q000097:blood; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D013552:Swine; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D013990:Tidal Volume; D013997:Time Factors; D055397:Ventilator-Induced Lung Injury / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators