title: Analysis of intra-aneurysmal flow for cerebral aneurysms with cerebral angiography.
abstract: OBJECTIVE
  Hemodynamics is an important factor in the development and rupture of cerebral aneurysms. Current techniques for measuring blood flow in cerebral aneurysms suffer from various limitations and have not been able to address our clinical needs. A new technique has been developed for effective evaluation of intra-aneurysmal flow based on high-frame-rate cerebral angiography, especially for flow-diverters.
  
  
  METHODS
  Six patients with 7 unruptured ICA aneurysms were imaged with a specially designed DSA protocol (a 3D DSA and a 2D DSA acquired at 30 frames/s, with a 2-mL/s contrast injection rate). Images of these cases were analyzed to determine the intra-aneurysmal flow based on the newly developed technique. Patient-specific aneurysm models were used for CFD calculation, and intra-aneurysmal flow rates were computed numerically. The intra-aneurysmal flow rates from the 2 methods were then compared.
  
  
  RESULTS
  There is a linear relationship between intra-aneurysmal flow ratios obtained from high-frame-rate cerebral angiography and CFD calculation (R = 0.99). A high frame rate (30 frames/s) provides a better estimate of intra-aneurysmal flow than low frame rates (7.5 frames/s and 15 frames/s).
  
  
  CONCLUSIONS
  The CFD calculation validates the estimate of intra-aneurysmal hemodynamics from cerebral angiography. The linear relationship obtained by using these 2 techniques can be used for real-time assessment of intra-aneurysmal hemodynamics for cerebral aneurysms.
authors.affiliation: Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA. jou@bcm.tmc.edu
authors.forename: L-D
authors.initials: LD
authors.lastname: Jou
authors.forename: M E
authors.initials: ME
authors.lastname: Mawad
mesh_terms: D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods; D002560:Cerebrovascular Circulation; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012680:Sensitivity and Specificity