title: High fiber probiotic fermented mare's milk reduces the toxic effects of mercury in rats.
abstract: BACKGROUND
  Since the advent of the Industrial Revolution in the late 19th century, we have all been unfortunately exposed to an increasingly toxic and polluted world. Among the most dangerous of these pollutants is mercury, which is considered to be the most toxic non-radioactive heavy metal. Fermented foods may help cleanse the body of heavy metals. Fermentation breaks down the nutrients in foods by the action of beneficial microorganisms and creates natural chelators that are available to bind toxins and remove them from the body.
  
  
  OBJECTIVE
  The current study was designed to determine the impact of feeding a high fiber probiotic fermented mare's milk on the biological effects of mercury toxicity in rat model.
  
  
  METHODS
  The high fiber fermented mare's milk containing probiotics was prepared and its sensory properties, chemical composition, and antioxidant activity were determined. A rat model of mercury toxicity was used. The effect of feeding the high fiber probiotic fermented mare's milk to rats, along with mercury ingestion, was determined by the analysis of several biochemical markers in serum and histopathological examinations of brain and kidney.
  
  
  RESULTS
  The high fiber fermented mare's milk containing probiotics was found to be acceptable by all test panels and volunteers. Mercury ingestion was found to cause biochemical and histopathological alterations in rat serum and tissues. The mercury-treated rats showed a decrease in body weight and an increase in kidney weight. Sera of the mercury treated rats showed alterations in biochemical parameters, and histopathological changes in brain and kidney. However, the rats fed high fiber fermented mare`s milk along with mercury ingestion showed improved histopathology of kidney and brain, and there was restoration of the biochemical parameters in serum to almost normal values.
  
  
  CONCLUSIONS
  Feeding high fiber fermented mare`s milk may reduce the toxic effects of mercury.
authors.affiliation: Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraidah, Al-Qassim, Saudi Arabia.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Abdel-Salam
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Dekheil
authors.forename: Ali
authors.initials: A
authors.lastname: Babkr
authors.forename: Mohammed
authors.initials: M
authors.lastname: Farahna
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Mousa