title: Electrophysiological and functional connectivity of the human supplementary motor area.
abstract: Neuro-imaging methods for detecting functional and structural inter-regional connectivity are in a rapid phase of development. While reports of regional connectivity patterns based on individual methods are becoming common, studies comparing the results of two or more connectivity-mapping methods remain rare. In this study, we applied transcranial magnetic stimulation during PET imaging (TMS/PET), a stimulation-based method, and meta-analytic connectivity modeling (MACM), a task-based method to map the connectivity patterns of the supplementary motor area (SMA). Further, we drew upon the behavioral domain meta-data of the BrainMap® database to characterize the behavioral domain specificity of two maps. Both MACM and TMS/PET detected multi-synaptic connectivity patterns, with the MACM-detected connections being more extensive. Both MACM and TMS/PET detected connections belonging to multiple behavioral domains, including action, cognition and perception. Finally, we show that the two connectivity-mapping methods are complementary in that, the MACM informed on the functional nature of SMA connections, while TMS/PET identified brain areas electrophysiologically connected with the SMA. Thus, we demonstrate that integrating multimodal database and imaging techniques can derive comprehensive connectivity maps of brain areas.
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA. narayana@uthscsa.edu
authors.forename: Shalini
authors.initials: S
authors.lastname: Narayana
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
authors.forename: Nitin
authors.initials: N
authors.lastname: Tandon
authors.forename: Crystal
authors.initials: C
authors.lastname: Franklin
authors.forename: Jack L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult