title: Efficacy & safety of iodopovidone pleurodesis: a systematic review & meta-analysis.
abstract: OBJECTIVE
  Chemical pleurodesis is an accepted therapy for patients with recurrent pleural effusions and pneumothorax. Iodopovidone has been shown to be safe and effective for chemical pleurodesis in several studies. The aim of this systematic review was to update a previously reported meta-analysis on the efficacy and safety of iodopovidone pleurodesis.
  
  
  METHODS
  Two databases MEDLINE and EMBASE were searched for a period (1952-2010), and studies that have reported success rates with iodopovidone pleurodesis were selected. The proportions with 95 per cent confidence interval (CI) were calculated to assess the outcomes in the individual studies and the results were pooled using a random effects model.
  
  
  RESULTS
  Thirteen eligible studies with 499 patients were included in the mata-analysis. The success rates varied from 70 to 100 per cent in different studies with the pooled success rate being 88.7 per cent (95% CI, 84.1 to 92.1). The success rate was not affected by the method (tube thoracostomy vs. thoracoscopy, 89.6 vs. 94.2%) or the indication of pleurodesis (pleural effusion vs. pneumothorax, 89.2 vs. 94.9%). The only significant complication reported was chest pain of varying degree. Systemic hypotension was reported in six patients across the studies. There were no deaths associated with iodopovidone pleurodesis. Statistical heterogeneity and publication bias were found.
  
  
  CONCLUSIONS
  Iodopovidone may be considered a safe and effective agent for chemical pleurodesis in patients with pleural effusions and recurrent pneumothoraces.
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India. riteshpgi@gmail.com
authors.forename: Ritesh
authors.initials: R
authors.lastname: Agarwal
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.forename: Ashutosh N
authors.initials: AN
authors.lastname: Aggarwal
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Gupta
mesh_terms: D002637:Chest Pain / Q000139:chemically induced; D006801:Humans; D010996:Pleural Effusion / Q000473:pathology / Q000628:therapy*; D018700:Pleurodesis / Q000009:adverse effects / Q000379:methods*; D011030:Pneumothorax / Q000473:pathology / Q000628:therapy*; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000009:adverse effects; D013627:Talc / Q000008:administration & dosage
chemical_list: D013627:Talc; D011206:Povidone-Iodine