title: How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects.
abstract: Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In this article, we argue that low grade metabolic acidosis and increased oxidative stress occurring in bone disease in part as a result of complications of diabetes, reinforce each other, and together constitute a double jeopardy for the development of bone fractures in diabetic subjects.
authors.affiliation: Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA. frassett@gcrc.ucsf.edu
authors.forename: L A
authors.initials: LA
authors.lastname: Frassetto
authors.forename: A
authors.initials: A
authors.lastname: Sebastian
mesh_terms: D000138:Acidosis / Q000453:epidemiology* / Q000503:physiopathology*; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology* / Q000503:physiopathology*; D005598:Fractures, Spontaneous / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D018384:Oxidative Stress; D015995:Prevalence; D012307:Risk Factors