title: Detection of sonoluminescence signals in a gel phantom in the presence of Protoporphyrin IX conjugated to gold nanoparticles.
abstract: The particles in a liquid decrease the ultrasonic intensity threshold required for cavitation onset. In this study, a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles (Au-PpIX) was used as a nucleation site for cavitation. The nonradiative relaxation time of Protoporphyrin IX in the presence of gold nanoparticles is longer than the similar time without gold nanoparticles. The acoustic cavitation activity was investigated via recording of the integrated sonoluminescence signal in the wavelength range of 220-700nm in a gel phantom by a cooled charge coupled device (CCD) at different intensities of 1MHz ultrasound. In order to confirm these results, a chemical dosimetric method was utilized, too. The recorded sonoluminescence signal in the gel phantom containing Au-PpIX was higher than the other phantoms. These records have been confirmed by the chemical dosimetric data. Therefore, we anticipate that a new nanoconjugate composed of Protoporphyrin IX and gold nanoparticles can act as an efficient sonoluminescence agent and could be introduced as a novel sonosensitizer for sonodynamic therapy.
authors.affiliation: Research Center and Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Vakil Abad Blvd., Mashhad, Iran.
authors.forename: Ameneh
authors.initials: A
authors.lastname: Sazgarnia
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shanei
authors.forename: Hossein
authors.initials: H
authors.lastname: Eshghi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hassanzadeh-Khayyat
authors.forename: Habibollah
authors.initials: H
authors.lastname: Esmaily
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Shanei
mesh_terms: D000162:Acoustics; D000704:Analysis of Variance; D005782:Gels; D006046:Gold / Q000737:chemistry*; D008163:Luminescent Measurements; D053768:Metal Nanoparticles / Q000737:chemistry*; D008968:Molecular Conformation; D058726:Nanoconjugates / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy; D019047:Phantoms, Imaging; D017319:Photosensitizing Agents / Q000737:chemistry*; D011524:Protoporphyrins / Q000737:chemistry*; D018709:Statistics, Nonparametric; D014464:Ultrasonic Therapy / Q000379:methods*
chemical_list: D005782:Gels; D058726:Nanoconjugates; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D006046:Gold; C028025:protoporphyrin IX