title: Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field.
abstract: Magnetic nanoparticles are widely used in bioapplications such as imaging and targeting tool. Their magnetic nature allows for the more efficient bioapplications by an external field gradient. However their combined effects have not yet been extensively characterized. Herein, we first demonstrate the biological effects of the communications between internalized bacterial magnetic nanoparticles (BMPs) and an external static magnetic field (SMF) on a standard human cell line. Combination of the BMPs and SMF act as the key factor leading to the alteration of cell structure and the enhanced cell growth. Also, their interaction reduced the apoptotic efficiency of human tumor cells induced by anticancer drugs. Microarray analysis suggests that these phenomena were caused by the alterations of GPCRs-mediated signal transduction originated in the interaction of internalized BMPs and the external SMF. Our findings may offer new approach for targeted cell therapy with the advantage of controlling cell viability by magnetic stimulation.
authors.affiliation: School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, South Korea.
authors.forename: Jaeha
authors.initials: J
authors.lastname: Shin
authors.forename: Chang-Hyuk
authors.initials: CH
authors.lastname: Yoo
authors.forename: Junghoon
authors.initials: J
authors.lastname: Lee
authors.forename: Misun
authors.initials: M
authors.lastname: Cha
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000528:radiation effects*; D042201:Magnetospirillum / Q000378:metabolism*; D008422:Materials Testing
chemical_list: D058185:Magnetite Nanoparticles