title: The power and pitfalls of IL-12.
abstract: In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2,3
authors.affiliation: National Heart, Lung, & Blood Institute, and National Cancer Institute.
authors.forename: Sid P
authors.initials: SP
authors.lastname: Kerkar
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Restifo