title: Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries.
abstract: Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
authors.affiliation: Unit of Lung Biology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: Kristina
authors.initials: K
authors.lastname: Rydell-Törmänen
authors.forename: Paul-André
authors.initials: PA
authors.lastname: Risse
authors.forename: Varsha
authors.initials: V
authors.lastname: Kanabar
authors.forename: Rushita
authors.initials: R
authors.lastname: Bagchi
authors.forename: Michael P
authors.initials: MP
authors.lastname: Czubryt
authors.forename: Jill R
authors.initials: JR
authors.lastname: Johnson
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D049109:Cell Proliferation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D006984:Hypertrophy; D009130:Muscle, Smooth / Q000166:cytology / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*