title: Integrin alphavbeta6 is involved in measles protein-induced airway immune suppression.
abstract: OBJECTIVE
  Measles infection causes immune suppression that contributes to morbidity and mortality of the patients; the mechanism is poorly understood. Regulatory T cells (Treg) play a critical role in immune suppression. Integrin alphavbeta6 (avb6) is associated with Treg's function. This study aims to investigate into the mechanism by which measles C protein (MVP)-induced avb6 contributes the generation of Tregs in the lung.
  
  
  METHODS
  MVP was introduced to mouse lung by nasal drops. The expression of avb6 by lung tissue was examined by reverse transcription polymerase chain reaction and Western blotting. The development of tolerogenic dendritic cells (DC) and Tregs in the lung and their functions was examined by flow cytometry. The suppressor function of MVP-induced Tregs was examined by cell culture models.
  
  
  RESULTS
  The exposure to MVP markedly increased the expression of avb6 in the lung epithelial cells. Administration of MVP significantly suppressed the levels of IL-4 and IFNγ as well as increases in Tregs in lung tissue. DCs captured the MVP in the lung and differentiate into tolerogenic DCs; the latter has the ability to induce Treg development in the lung. Activation of MVP-induced Tregs powerfully suppressed polarized CD4(+) T cells.
  
  
  CONCLUSIONS
  Exposure to MVP can induce Treg development in the lung that plays an important role in the suppression of CD4(+) T cell function.
authors.affiliation: Intensive Care Unit, Shengjing Hospital, China Medical University, Shenyang, China. xingmaowu8@163.com
authors.forename: Xing-Mao
authors.initials: XM
authors.lastname: Wu
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Liao
authors.forename: Hai-Yuan
authors.initials: HY
authors.lastname: Wang
authors.forename: Kai-Qiang
authors.initials: KQ
authors.lastname: Ji
authors.forename: Guo-Fu
authors.initials: GF
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Zang
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D007108:Immune Tolerance / Q000276:immunology*; D016023:Integrins / Q000378:metabolism*; D008168:Lung / Q000276:immunology* / Q000821:virology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014764:Viral Proteins / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D016023:Integrins; D014764:Viral Proteins; C073878:integrin alphavbeta6