title: [Bisphosphonate-related osteonecrosis of the jaws].
abstract: Bisphosphonate-related osteonecrosis of the jaws is a complication which can occur in patients treated with bisphosphonates. The pathogenesis is still poorly understood. Risk factors are invasive oral treatments with tooth extraction as a leading cause. Because of the complexity of the treatment of osteonecrosis of the jaws, prevention is of the utmost importance. Invasive oral treatments needed, should be performed before starting the treatment with bisphosphonates. Since osteonecrosis of the jaws is presenting relatively rare, it is understandable that guidelines with respect to prevention and treatment are not evidence-based.
authors.affiliation: Uit de afdeling Mondziekten, Kaak- en Aangezichtschirurgie van het VU medisch centrum in Amsterdam. i.vanderwaal@vumc.nl
authors.forename: I
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016723:Bone Remodeling / Q000187:drug effects; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000517:prevention & control; D010020:Osteonecrosis / Q000139:chemically induced* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates