title: [Survey on the recessive infection of pathogen to hand-foot-mouth disease among healthy adults and children in Guangdong province].
abstract: OBJECTIVE
  To understand the pathogen-carrying status of hand-foot-mouth disease (HFMD) among healthy people in Guangdong province.
  
  
  METHODS
  Stool specimens were collected randomly on 7 age groups from 7 cities in Guangdong province. Real-time RT-PCR was used to detect enterovirus (EV), enterovirus 71 (EV71) and coxsackie virus A16 (CA16).
  
  
  RESULTS
  Altogether, 1285 stool specimens were collected. The positive rates of EV71, CA16 and other enterovirus were 0.39% (5/1285), 0.23% (3/1285) and 7.00% (90/1285), respectively. The highest EV71 positive rate (1.79%) was among the 4-6-year-old group, followed by the age group 0 - 3 with positive rate as 0.67%. EV71 was not found among the rest age groups. The highest CA16 positive rate (1.35%) was among the 4 - 6 year-olds group, but the CA16 was not found among the rest age groups. EV71 was only found among native population, with the positive-rate as 0.47%. CA16-positive rate was 0.19% among the native population and 0.85% among floating population, with no significant difference found (P > 0.05). The EV71 positive rate was 0.36% among rural residents and 0.54% among urban residents, but with no significant difference (P > 0.05). All CA16 was found among the urban residents.
  
  
  CONCLUSIONS
  Recessive infection of EV71 and CA16 were only found among 0-6 year-old group but not found among other groups, which suggested that the approaches on prevention and control should be targeted to all children especially on pre-school children.
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Ai-ping
authors.initials: AP
authors.lastname: Deng
authors.forename: Yong-hui
authors.initials: YH
authors.lastname: Zhang
authors.forename: Li-mei
authors.initials: LM
authors.lastname: Sun
authors.forename: Han-ri
authors.initials: HR
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Chang-wen
authors.initials: CW
authors.lastname: Ke
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: He
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.forename: Jin-yan
authors.initials: JY
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002353:Carrier State / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D055815:Young Adult