title: Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing.
abstract: Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.
authors.affiliation: Université de Nice, INSERM 1091, CNRS 7277, and France Institute of Biology, Parc Valrose, 06108 Nice, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Colombani
authors.forename: Ditte S
authors.initials: DS
authors.lastname: Andersen
authors.forename: Pierre
authors.initials: P
authors.lastname: Léopold
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D004440:Ecdysone / Q000096:biosynthesis; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D060227:Imaginal Discs / Q000254:growth & development*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D007814:Larva / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008675:Metamorphosis, Biological; D034622:RNA Interference; D017384:Sequence Deletion; D013997:Time Factors; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; C572149:insulin-like peptide 8, Drosophila; D004440:Ecdysone; D048031:JNK Mitogen-Activated Protein Kinases