title: Albendazole therapy for coagulation abnormality in children with eosinophilia.
abstract: Hemorrhage may be associated with eosinophilia. Here, 2 pediatric cases of coagulation abnormality were reported. The 2 children presented ecchymoses and petechiae in the skin. Laboratory investigations revealed hypereosinophilia in the peripheral blood. Moreover, the activity of coagulation factor IX significantly decreased. The serum immunoglobulin G (IgG) antibody to cysticercus was positive in patient 1, and IgG antibodies to cysticercus and plerocercoid were positive in patient 2. These 2 patients received 2 courses of albendazole therapy, at 15 mg/kg/day in divided doses for 10 days for each course. They responded well to the therapy. This report indicates that patients with hypereosinophilia and bleeding abnormalities should undergo evaluation of coagulation pathways, including measurements of coagulation factors.
authors.affiliation: Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Lu-Hong
authors.initials: LH
authors.lastname: Xu
authors.forename: Jian-Pei
authors.initials: JP
authors.lastname: Fang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Zhang
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Weng
authors.forename: Ke
authors.initials: K
authors.lastname: Huang
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Guo
mesh_terms: D015766:Albendazole / Q000008:administration & dosage*; D000871:Anthelmintics / Q000008:administration & dosage*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000097:blood / Q000188:drug therapy*; D005164:Factor IX / Q000378:metabolism; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D012074:Remission Induction
chemical_list: D000871:Anthelmintics; D007074:Immunoglobulin G; D005164:Factor IX; D015766:Albendazole