title: [Study on the distribution of buprenorphione in the bodies of the rabbits].
abstract: OBJECTIVE
  To investigate the distribution of buprenorphione in the bodies of rabbits.
  
  
  METHODS
  Buprenorphione was administrated to rabbits orally or by intravenous injection (0.04 mg/kg buprenorphione). Two hours after administration, rabbits were killed and their blood, urine, liver, kidney, lung, stomach, brain, heart, stomach content and feces were collected. The concentrations of buprenorphione in these body fluids and tissues were determined by liquid chromatography-mass spectrometry (LC-MS).
  
  
  RESULTS
  The results show the distribution of buprenorphione in rabbit's body: urine>stomach content>brain >heart >stomach>lung> kidney > liver > blood> feces.
  
  
  CONCLUSIONS
  The method developed can be used for the detection of buprenorphione in biological fluids and tissues in forensic practice. Urine is the preferred sample for screening for buprenorphione abuse.
authors.affiliation: Department of Criminal Technology, Hunan Police Academy, Changsha 410138, China. liudongxian@yahoo.com.cn
authors.forename: Dongxian
authors.initials: D
authors.lastname: Liu
authors.forename: Jiangnan
authors.initials: J
authors.lastname: He
mesh_terms: D000701:Analgesics, Opioid / Q000493:pharmacokinetics; D000818:Animals; D002047:Buprenorphine / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine