title: Meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapy.
abstract: A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC(50) values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.
authors.affiliation: National Institute of Science Education and Research (NISER), Bhubaneswar-751005, Orissa, India.
authors.forename: Ajesh P
authors.initials: AP
authors.lastname: Thomas
authors.forename: P S
authors.initials: PS
authors.lastname: Saneesh Babu
authors.forename: S
authors.initials: S
authors.lastname: Asha Nair
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishnan
authors.forename: Danaboyina
authors.initials: D
authors.lastname: Ramaiah
authors.forename: Tavarekere K
authors.initials: TK
authors.lastname: Chandrashekar
authors.forename: A
authors.initials: A
authors.lastname: Srinivasan
authors.forename: M
authors.initials: M
authors.lastname: Radhakrishna Pillai
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001557:Benzenesulfonates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002843:Chromatin / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D000432:Methanol / Q000737:chemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D026082:Singlet Oxygen / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D001557:Benzenesulfonates; D002843:Chromatin; D017319:Photosensitizing Agents; D011166:Porphyrins; D017382:Reactive Oxygen Species; C575277:meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin; D014867:Water; D026082:Singlet Oxygen; D000432:Methanol