title: [Bronchiolitis obliterans after Stevens-Johnson syndrome].
abstract: BACKGROUND
  Bronchiolitis obliterans is a non-reversible lung disease in which the inflammatory process ultimately leads to obstruction of the bronchioles. This condition often occurs after a lung or bone marrow transplantation, and sometimes respiratory tract infection. Clinical presentation is that of persistent and increasing airway obstruction. The gold standard for diagnosis is open lung biopsy. Treatment is symptomatic and aimed at preventing further lung damage.
  
  
  METHODS
  An 8-year-old girl was treated for a suspected pneumonia. Two weeks later she developed Stevens-Johnson syndrome followed by severe dyspnoea. A CT scan of the chest revealed findings consistent with bronchiolitis obliterans. Methylprednisone pulse therapy was ineffective. Due to respiratory insufficiency she underwent a lung transplantation, which to date has been successful.
  
  
  CONCLUSIONS
  Bronchiolitis obliterans after Stevens-Johnson syndrome should be considered in patients with recurrent and progressive respiratory symptoms with typical findings on a CT scan. Lung transplantation is often the only therapeutic option.
authors.affiliation: Erasmus Medisch Centrum - Sophia Kinderziekenhuis, afd. Kindergeneeskunde, Rotterdam, the Netherlands.
authors.forename: Eline A M
authors.initials: EA
authors.lastname: Zijtregtop
authors.forename: Mariëlle W
authors.initials: MW
authors.lastname: Pijnenburg
authors.forename: Bart L
authors.initials: BL
authors.lastname: Rottier
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Duijts
mesh_terms: D001989:Bronchiolitis Obliterans / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D013262:Stevens-Johnson Syndrome / Q000150:complications*; D016896:Treatment Outcome