title: Lipoid proteinosis in the eastern Mediterranean region of Turkey.
abstract: BACKGROUND
  Lipoid proteinosis (LP), also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease, is a rare autosomal recessive genodermatosis. Hyalin-like material is deposited in multiple organs, including the skin, oral mucosa, larynx, and brain. Only about 300 cases have been reported in the literature so far. Occurrence of LP in siblings is also rare. The reasons for relatively large number of cases, the clinical features of the patients, and the association of LP with other clinical conditions are described in this article.
  
  
  OBJECTIVE
  The aim of this study is to show that LP is not rare in Turkey and consanguineous marriage is still a social problem.
  
  
  METHODS
  We included patients between the years of 2008-2011 with lesions resembling LP. Based on the findings of clinical and histological examination of all cases, a diagnosis of LP was made.
  
  
  RESULTS
  We presented six different families with multiple family members suffered from LP. In total, we determined eight children and six adult patients. Three of eight children were from the same family (sisters), the other three children belonged to another family (brothers), two children were from another family (brother and sister), and the adult patients were from three different families.
  
  
  CONCLUSIONS
  Patients with LP are likely to present first to a dermatologist because of the appearance of their skin; therefore, it is important that the dermatologic diagnosis is not to be missed. We described patients with LP and discuss the salient features of this disease.
authors.affiliation: Department of Dermatology, School of Medicine, University of Mustafa Kemal, Hatay, Turkey. catahan85@yahoo.com
authors.forename: Asena C
authors.initials: AC
authors.lastname: Dogramaci
authors.forename: Murat M
authors.initials: MM
authors.lastname: Celik
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.forename: Hanifi
authors.initials: H
authors.lastname: Bayarogullari
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D003241:Consanguinity; D005190:Family; D005192:Family Health; D005260:Female; D006801:Humans; D008065:Lipoid Proteinosis of Urbach and Wiethe / Q000235:genetics* / Q000473:pathology*; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D012867:Skin / Q000473:pathology*; D014421:Turkey