title: Partial trisomy of chromosome 13 as a single cytogenetic abnormality in an Italian case of nasal NK/T lymphoma.
abstract: Extranodal NK/T lymphoma, nasal type, is an uncommon neoplasm that occurs with a higher prevalence among Asian populations and Native American populations of Central and Southern America. In Western countries, this tumor is extremely rare, accounting for less than 1.5% of all non-Hodgkin lymphomas. Cytogenetic analyses have been performed only in a limited number of cases, mainly because of technical problems related to extensive necrosis and the scarcity of clinical samples, and these have shown complex karyotypes with no specific chromosomal translocations. Here, we report the cytogenetic characterization of a clinically aggressive nasal NK/T-cell lymphoma occurring in a 40-year-old Italian male patient, in which the sole chromosome abnormality was a partial trisomy of chromosome 13.
authors.affiliation: Department of Surgical and Morphological Sciences, Unit of Pathology, University of Insubria-Ospedale di Circolo, Varese, Italy. silvia.uccella@uninsubria.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Uccella
authors.forename: Barbara
authors.initials: B
authors.lastname: Bernasconi
authors.forename: Isabella
authors.initials: I
authors.lastname: Ricotti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Proserpio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Calabrese
authors.forename: Carlo
authors.initials: C
authors.lastname: Capella
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Tibiletti
mesh_terms: D000328:Adult; D025063:Chromosome Disorders / Q000235:genetics* / Q000473:pathology; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D020732:Cytogenetic Analysis; D006801:Humans; D007558:Italy; D007621:Karyotyping; D054391:Lymphoma, Extranodal NK-T-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy / Q000235:genetics* / Q000473:pathology; D000073839:Trisomy 13 Syndrome