title: 5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in Han Chinese.
abstract: BACKGROUND
  Prior research has shown that the amygdala of carriers of the short allele (s) of the serotonin transporter (5-HTT) gene (5-HTTLPR) have a larger response to negative emotional stimuli and higher spontaneous activity during the resting state than non-carriers. However, recent studies have suggested that the effects of 5-HTTLPR may be specific to different ethnic groups. Few studies have been conducted to address this issue.
  
  
  RESULTS
  Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was conducted on thirty-eight healthy Han Chinese subjects (l/l group, n = 19; s/s group, n = 19) during the resting state and during an emotional processing task. Compared with the s/s group, the l/l group showed significantly increased regional homogeneity or local synchronization in the right amygdala during the resting state (|t|>2.028, p<0.05, corrected), but no significant difference was found in the bilateral amygdala in response to negative stimuli in the emotional processing task.
  
  
  CONCLUSIONS
  5-HTTLPR can alter the spontaneous activity of the amygdala in Han Chinese. However, the effect of 5-HTTLPR on the amygdala both in task state and resting state in Asian population was no similar with Caucasians. They suggest that the effect of 5-HTTLPR on the amygdala may be modulated by ethnic differences.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors.forename: Sufang
authors.initials: S
authors.lastname: Li
authors.forename: Qihong
authors.initials: Q
authors.lastname: Zou
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Deyi
authors.initials: D
authors.lastname: Wang
authors.forename: Chaogan
authors.initials: C
authors.lastname: Yan
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
mesh_terms: D000679:Amygdala / Q000378:metabolism / Q000502:physiology*; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D001481:Basal Metabolism; D001519:Behavior / Q000502:physiology; D004644:Emotions / Q000502:physiology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins