title: A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis.
abstract: BACKGROUND
  Plaque-type psoriasis manifests with various morphological phenotypes and different clinical activity over time in the same individual or from one patient to another. Circulating cytokines, especially T-helper (Th) 1- and Th17-related, have been suggested to reflect the inflammatory nature of psoriasis. However, studies regarding cytokine profile according to morphological phenotypes are quite scarce.
  
  
  OBJECTIVE
  We sought to analyse the circulating Th1 and Th17 cytokines according to clinical phenotype and investigated the correlation between disease severity [Psoriasis Area and Severity Index (PASI)] and the serum level of inflammatory cytokines.
  
  
  METHODS
  Seventy-one patients with psoriasis were divided into two groups according to clinical phenotype: chronic stable (CS) and eruptive inflammatory (EI). Th1- and Th17-derived cytokines were measured using multiplex cytokine assay.
  
  
  RESULTS
  It was noted that interleukin (IL)-1 receptor antagonist and IL-17A were elevated in the EI group compared with the CS group. We also noticed that the PASI is relatively well correlated with serum cytokine level in the CS state but not as well in the EI counterpart.
  
  
  CONCLUSIONS
  The level of serum inflammatory cytokines differs according to morphological phenotype. Also, the PASI does not seem to be a suitable tool to assess disease severity in patients with psoriasis with EI characteristics.
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Y B
authors.initials: YB
authors.lastname: Choe
authors.forename: Y J
authors.initials: YJ
authors.lastname: Hwang
authors.forename: H J
authors.initials: HJ
authors.lastname: Hahn
authors.forename: J W
authors.initials: JW
authors.lastname: Jung
authors.forename: H J
authors.initials: HJ
authors.lastname: Jung
authors.forename: Y W
authors.initials: YW
authors.lastname: Lee
authors.forename: K J
authors.initials: KJ
authors.lastname: Ahn
authors.forename: J I
authors.initials: JI
authors.lastname: Youn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007375:Interleukin-1 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018417:Th1 Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D020381:Interleukin-17