title: Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy.
abstract: In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.
authors.affiliation: Institut des Biomolécules Max Mousseron UMR 5247 CNRS, Université Montpellier 1, Université Montpellier 2, Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: Youssef
authors.initials: Y
authors.lastname: Mir
authors.forename: Cédric
authors.initials: C
authors.lastname: Rouxel
authors.forename: David
authors.initials: D
authors.lastname: Brevet
authors.forename: Ouahiba
authors.initials: O
authors.lastname: Hocine
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Audrey
authors.initials: A
authors.lastname: Gallud
authors.forename: Afitz
authors.initials: A
authors.lastname: Da Silva
authors.forename: Olivier
authors.initials: O
authors.lastname: Mongin
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Sébastien
authors.initials: S
authors.lastname: Richeter
authors.forename: Bernard
authors.initials: B
authors.lastname: Loock
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: Alain
authors.initials: A
authors.lastname: Morère
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Laurence
authors.initials: L
authors.lastname: Raehm
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004705:Endocytosis; D005690:Galactose / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008358:Mannose / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010778:Photochemotherapy; D019572:Retinal Neoplasms / Q000188:drug therapy; D012175:Retinoblastoma / Q000188:drug therapy; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D012822:Silicon Dioxide; D008358:Mannose; D005690:Galactose; D002166:Camptothecin