title: Anti-inflammatory sesquiterpenes and sesquiterpene dimers from Chloranthus fortunei.
abstract: A novel lindenane sesquiterpene with an unprecedented 18-membered triester ring, named chlorafortulide (1), along with one known lindenane sesquiterpene (2) and nine known lindenane sesquiterpene dimers (3-11), was isolated from the whole plant of Chloranthus fortunei. Their structures and relative configurations were elucidated on the basis of spectroscopic analysis. All the isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Henriol D (4), shizukaols E (8), G (9), M (10), and O (11) showed significant anti-inflammatory activities with IC(50) values of 1.90, 3.68, 1.95, 7.01, and 1.95 μM, respectively.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Zhang
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Oyama
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Chao
authors.initials: C
authors.lastname: Guo
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C575754:chlorafortulide; D009569:Nitric Oxide