title: Dexmedetomidine in a child with methylphenidate intoxication.
abstract: Methylphenidate intoxication, due to accidental ingestion, is a common occurrence in pediatrics. Symptoms of extreme agitation are typically controlled with benzodiazepines or barbiturates. There is, however, a legitimate risk of mechanical ventilation due to respiratory depression with increasing doses of benzodiazepines. The authors describe a case of 7-y-old girl with methylphenidate toxicity where dexmedetomidine was successfully used to manage agitation and cardiovascular stimulation without respiratory compromise.
authors.affiliation: Pediatric Intensive Care Unit, Section of Critical Care Medicine, Children's Hospital Colorado, 13123 East 17th Ave, Mail Stop 8414, Aurora, CO 80045, USA. dbagdure@peds.umaryland.edu
authors.forename: Dayanand N
authors.initials: DN
authors.lastname: Bagdure
authors.forename: Girija R
authors.initials: GR
authors.lastname: Bhoite
authors.forename: Pamela D
authors.initials: PD
authors.lastname: Reiter
authors.forename: Emily L
authors.initials: EL
authors.lastname: Dobyns
mesh_terms: D000061:Accidents, Home; D000697:Central Nervous System Stimulants / Q000506:poisoning*; D002648:Child; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008774:Methylphenidate / Q000506:poisoning*; D011595:Psychomotor Agitation / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D008774:Methylphenidate; D020927:Dexmedetomidine