title: Adult-onset Still's disease complicated by autoimmune hepatitis: successful treatment with infliximab.
abstract: A 17-year-old woman was previously diagnosed with autoimmune hepatitis (AIH) by liver biopsy. Adult-onset Still's disease (AOSD) was subsequently diagnosed on the basis of high fever, arthralgia, erythema, leukocytosis (>80% granulocytes), cervical lymph node swelling, splenomegaly, and hyperferritinemia. Her symptoms and liver dysfunction improved with prednisolone of 60 mg daily and subsequently methotrexate was added. However her symptoms and liver dysfunction relapsed when prednisolone was tapered to 20 mg/day. Therefore infliximab was introduced additionally and her symptoms and liver dysfunction subsided. To our knowledge, this is the first reported case of AOSD with AIH diagnosed by liver biopsy.
authors.affiliation: Center for Rheumatic Disease, Iizuka Hospital, Japan. fujii-kenji@sawara-hp.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujii
authors.forename: Ryo
authors.initials: R
authors.lastname: Rokutanda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Osugi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Koyama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ota
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab