title: Long-term ongoing coagulopathy in premature infants with respiratory distress syndrome.
abstract: The previously reported activated intravascular coagulation system in the acute phase of respiratory distress syndrome (RDS) has not been evaluated in the long term. We assessed the activities of coagulation system of a cohort of premature infants with RDS in comparison with healthy premature infants (HPIs), healthy mature infants (HMIs), and pediatric laboratory controls over a 6-month period. Cord and venous blood samples were taken at birth, at the first month and sixth month. Protein C (PC), free protein S (f-PS), and antithrombin (AT) activities, thrombin-antithrombin (TAT) complex, prothrombin fragment 1 + 2 (PF1 + 2), and fibrinogen levels were measured. Mean PC, f-PS, d-dimer, and fibrinogen values were similar at all periods for HPI and RDS groups. Low neonatal anticoagulant proteins increased within 6 months in HMI and HPI groups. However, in RDS group, the AT activity remained significantly lower together with significantly higher TAT and PF1 + 2 levels both at the first month and at sixth month, suggesting a long-term consumption coagulopathy.
authors.affiliation: 1Division of Neonatology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Muammer
authors.initials: M
authors.lastname: Buyukinan
authors.forename: Deniz
authors.initials: D
authors.lastname: Yilmaz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.forename: Ozge Altun
authors.initials: OA
authors.lastname: Koroglu
authors.forename: Mete
authors.initials: M
authors.lastname: Akisu
authors.forename: Kaan
authors.initials: K
authors.lastname: Kavakli
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kultursay
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000473:pathology; D001779:Blood Coagulation Factors / Q000378:metabolism; D001780:Blood Coagulation Tests; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*
chemical_list: D001779:Blood Coagulation Factors