title: Persistent Sepsis-Induced Hypotension without Hyperlactatemia: A Distinct Clinical and Physiological Profile within the Spectrum of Septic Shock.
abstract: Introduction. A subgroup of septic shock patients will never develop hyperlactatemia despite being subjected to a massive circulatory stress. Maintenance of normal lactate levels during septic shock is of great clinical and physiological interest. Our aim was to describe the clinical, hemodynamic, perfusion, and microcirculatory profiles associated to the absence of hyperlactatemia during septic shock resuscitation. Methods. We conducted an observational study in septic shock patients undergoing resuscitation. Serial clinical, hemodynamic, and perfusion parameters were registered. A single sublingual microcirculatory assessment was performed in a subgroup. Patients evolving with versus without hyperlactatemia were compared. Results. 124 septic shock patients were included. Patients without hyperlactatemia exhibited lower severity scores and mortality. They also presented higher platelet counts and required less intensive treatment. Microcirculation was assessed in 45 patients. Patients without hyperlactatemia presented higher PPV and MFI values. Lactate was correlated to several microcirculatory parameters. No difference in systemic flow parameters was observed. Conclusion. Persistent sepsis-induced hypotension without hyperlactatemia is associated with less organ dysfunctions and a very low mortality risk. Patients without hyperlactatemia exhibit less coagulation and microcirculatory derangements despite comparable macrohemodynamics. Our study supports the notion that persistent sepsis-induced hypotension without hyperlactatemia exhibits a distinctive clinical and physiological profile.
authors.affiliation: Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Glenn
authors.initials: G
authors.lastname: Hernandez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Bruhn
authors.forename: Ricardo
authors.initials: R
authors.lastname: Castro
authors.forename: Cesar
authors.initials: C
authors.lastname: Pedreros
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Rovegno
authors.forename: Eduardo
authors.initials: E
authors.lastname: Kattan
authors.forename: Enrique
authors.initials: E
authors.lastname: Veas
authors.forename: Andrea
authors.initials: A
authors.lastname: Fuentealba
authors.forename: Tomas
authors.initials: T
authors.lastname: Regueira
authors.forename: Carolina
authors.initials: C
authors.lastname: Ruiz
authors.forename: Can
authors.initials: C
authors.lastname: Ince