abstract: Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis.
authors.affiliation: Ludwig Boltzmann Institute for Cancer Research (LBI-CR)  , Währinger Strasse 13a, A-1090 Vienna, Austria.
authors.forename: Paulina
authors.initials: P
authors.lastname: Rampetsreiter
authors.forename: Emilio
authors.initials: E
authors.lastname: Casanova
authors.forename: Robert
authors.initials: R
authors.lastname: Eferl