title: Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues.
abstract: We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic β-cells and in vitro vasodilator and anti-aggregatory activities, is reported.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Torino, Italy.
authors.forename: Yasinalli
authors.initials: Y
authors.lastname: Tamboli
authors.forename: Loretta
authors.initials: L
authors.lastname: Lazzarato
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Marini
authors.forename: Stefano
authors.initials: S
authors.lastname: Guglielmo
authors.forename: Michela
authors.initials: M
authors.lastname: Novelli
authors.forename: Pascale
authors.initials: P
authors.lastname: Beffy
authors.forename: Pellegrino
authors.initials: P
authors.lastname: Masiello
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000737:chemistry*; D051381:Rats; D013453:Sulfonylurea Compounds / Q000737:chemistry; D014044:Tolbutamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D020030:Nitric Oxide Donors; D013453:Sulfonylurea Compounds; D014665:Vasodilator Agents; D014044:Tolbutamide