title: Antimicrobial resistance of Escherichia coli strains causing neonatal sepsis between 1998 and 2008.
abstract: BACKGROUND
  Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS) and their evolution.
  
  
  METHODS
  E. coli strains from EONS and hospital-acquired LONS collected at the Hospital Clinic of Barcelona were included in the study.
  
  
  RESULTS
  No statistically significant differences in resistance profiles were found between strains causing EONS and LONS. An increase in the resistance to all the antimicrobial agents studied was observed for the period 2000-2008 in comparison with the 1985-1999 period, with the increase in resistance to gentamicin, piperacillin and tobramycin being statistically significant. Two strains carried the bla(CTX-M) genes (bla(CTX-M-14) and bla(CTX-M-15)).
  
  
  CONCLUSIONS
  The increase in ampicillin and gentamicin resistance makes a change in the treatment of neonates necessary.
authors.affiliation: Barcelona Centre for International Health Research, CRESIB, Hospital Clinic-University of Barcelona, Barcelona, Spain.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Guiral
authors.forename: Jordi
authors.initials: J
authors.lastname: Bosch
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.forename: Sara M
authors.initials: SM
authors.lastname: Soto
mesh_terms: D000667:Ampicillin / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification*; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology*; D014031:Tobramycin / Q000494:pharmacology / Q000627:therapeutic use; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000667:Ampicillin; D001618:beta-Lactamases; D014031:Tobramycin; D010878:Piperacillin