title: β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study.
abstract: The association of doxorubicin (DOX) and artemisinin (ART) to a β-CyD-epichlorohydrin crosslinked polymer (pβ-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer pβ-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame.
authors.affiliation: Istituto per la Sintesi Organica e la Fotoreattività, ISOF-CNR, Bologna, Italy.
authors.forename: Resmi
authors.initials: R
authors.lastname: Anand
authors.forename: Francesco
authors.initials: F
authors.lastname: Manoli
authors.forename: Ilse
authors.initials: I
authors.lastname: Manet
authors.forename: Samia
authors.initials: S
authors.lastname: Daoud-Mahammed
authors.forename: Valentina
authors.initials: V
authors.lastname: Agostoni
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
authors.forename: Sandra
authors.initials: S
authors.lastname: Monti
mesh_terms: D037621:Artemisinins / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004811:Epichlorohydrin / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013057:Spectrum Analysis; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D037621:Artemisinins; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D004811:Epichlorohydrin; D004317:Doxorubicin; C031327:artemisinin