title: Paraurethral striated muscular structures and pelvic floor muscles contribute to resting urethral closure pressure in rats.
abstract: OBJECTIVE
  We investigated physiological functions of the extraordinary muscular structure in the paraurethral area with pelvic floor muscle and the impact of these muscular structures on the resting maximal urethral closure pressure (MUCP) in rats.
  
  
  METHODS
  Sixteen female Wister rats were divided into four groups: Groups I and II rats received 5 and 2.5 IU botulinum toxin A (BoNT-A), respectively, injected into the bilateral paraurethral striated muscles. Group III rats received 2.5 IU BoNT-A injected into the bilateral pelvic floor muscles, and group IV rats received 2.5 IU BoNT-A injected into the unilateral pelvic floor muscles. Measurements of MUCP were made at different time points after BoNT-A injection.
  
  
  RESULTS
  All groups showed a rapid reduction in average MUCP by 70-80 % after BoNT-A injection, regardless of injection site or side.
  
  
  CONCLUSIONS
  Paraurethral striated muscular structures and the pelvic floor muscles possess the function of maintaining resting MUCP in rats.
authors.affiliation: Department of Obstetrics & Gynecology, Taipei Country Hospital, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taipei, Taiwan, Republic of China.
authors.forename: Hung-Yen
authors.initials: HY
authors.lastname: Chin
authors.forename: Kuan-Cheng
authors.initials: KC
authors.lastname: Lin
authors.forename: Chin-Jung
authors.initials: CJ
authors.lastname: Wang
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Chiang
authors.forename: Hann-Chorng
authors.initials: HC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D007267:Injections; D023421:Models, Animal; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D054792:Muscle, Striated / Q000187:drug effects / Q000502:physiology*; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology; D017773:Pelvic Floor / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012146:Rest / Q000502:physiology*; D014521:Urethra / Q000502:physiology*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A