title: Effects of nutritional supplementation on children with HIV/AIDS in China.
abstract: The purpose of the review was to explore the effects of nutritional supplements in children with HIV/AIDS. Nutritional supplements were found to have both positive and negative effects in HIV/ AIDS children. It was found that selenium helps to boost immunity. Vitamin D supplementation was found to delay mother to child transmission (MTCT) of HIV and to reduce stunted growth associated with persistent diarrhea. Vitamins B, C, and E were found to delay HIV disease progression, reduce oxidative stress and HIV viral load. Multivitamin supplementation was found to be more effective in delaying HIV disease progression. Protein nutrition was found to improve cognitive and motor developments of children as well as helping HIV-positive children achieve 100% weight for height. Some nutrient supplements, however, were found to have negative effects on HIV/AIDS children. Vitamin A was found to double the risk of mortality of HIV/AIDS in infants exposed to HIV via breastfeeding. Zinc was found to have a positive effect on production of infectious virus through its action on reverse transcriptase. Some micronutrional interact with each other leading to harmful side effects such as diarrhea. Some nutritional supplements interact with antiretroviral drugs leading to treatment failure. It is important for children to be given right doses of nutritional supplements and that their immune system should be closely monitored.
authors.affiliation: School of Nursing, Central South University, Changsha 410013, China.
authors.forename: Zgambo
authors.initials: Z
authors.lastname: Maggie
authors.forename: Guoping
authors.initials: G
authors.lastname: He
authors.forename: Honghong
authors.initials: H
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy*; D002648:Child; D004044:Dietary Proteins / Q000008:administration & dosage; D019587:Dietary Supplements / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage* / Q000009:adverse effects; D012643:Selenium / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
chemical_list: D004044:Dietary Proteins; D018977:Micronutrients; D014815:Vitamins; D012643:Selenium; D015032:Zinc