title: Association between self-reported questionnaire data on fertility and results of hormone analyses in women after childhood cancer: a cross-sectional study.
abstract: OBJECTIVE
  The aim of this study was to compare self-reported questionnaire-based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence.
  
  
  METHODS
  In a cross-sectional study, questionnaires and hormone analyses (anti-Müllerian hormone [AMH], follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone) were evaluated in 86 female former pediatric oncology patients in Berlin in 2009.
  
  
  RESULTS
  Eighty-six women (median age 23 years, range 19-41) participated in the study with a median follow up of 14 years (range 2-30) after diagnosis. Among women with information on permanent and transient amenorrhea, 9% (5/55) of the women stated that they were permanently amenorrheic. Among women not taking oral contraceptives and giving information on the regularity of their menstrual cycle, 18% (4/22) had an irregular menstrual cycle and 82% (18/22) had a regular menstrual cycle. The median AMH values for women who were categorized as infertile by questionnaire-based information were significantly lower than the AMH values of women who were categorized as fertile by questionnaire (0.05 vs 2.2 ng/mL, P = 0.004). Questionnaire-based categories on the regularity of the menstrual cycle and categories based on AMH values showed a satisfying percentage agreement (66.7%) and were moderately correlated (r = 0.42, P = 0.002).
  
  
  CONCLUSIONS
  Self-reported questionnaire data used to detect fertility impairment has limited correspondence with objectively measured AMH values.
authors.affiliation: Department of Gynaecology, Charité- University Medical Center, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Jantke
authors.forename: Rosa
authors.initials: R
authors.lastname: Rendtorff
authors.forename: Ralf
authors.initials: R
authors.lastname: Dittrich
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.forename: Constanze
authors.initials: C
authors.lastname: Pfitzer
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hohmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Keil
authors.forename: Anja
authors.initials: A
authors.lastname: Borgmann-Staudt
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001604:Berlin; D015415:Biomarkers / Q000097:blood; D059248:Chemoradiotherapy / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D057566:Self Report; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone