title: Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
abstract: Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka 580003, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Mohammed Iqbal
authors.forename: Ashraf Y
authors.initials: AY
authors.lastname: Khan
authors.forename: Mallikarjun B
authors.initials: MB
authors.lastname: Kalashetti
authors.forename: Ningaraddi S
authors.initials: NS
authors.lastname: Belavagi
authors.forename: Young-Dae
authors.initials: YD
authors.lastname: Gong
authors.forename: Imitiyaz Ahmed M
authors.initials: IA
authors.lastname: Khazi
mesh_terms: D000818:Animals; D060326:Chemistry Techniques, Synthetic; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010069:Oxadiazoles / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013844:Thiazoles / Q000737:chemistry*; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014230:Triazoles / Q000737:chemistry*
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010069:Oxadiazoles; D013844:Thiazoles; D045162:Thiazolidinediones; D014230:Triazoles; C089946:2,4-thiazolidinedione