title: Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer.
abstract: Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). In this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. In contrast, no association was observed between ACE (I/D) polymorphism with EOC. The ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.
authors.affiliation: Molecular Gynecology Laboratory, Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Silvana Aparecida Alves
authors.initials: SA
authors.lastname: Correa-Noronha
authors.forename: Samuel Marcos Ribeiro de
authors.initials: SM
authors.lastname: Noronha
authors.forename: Cheryl
authors.initials: C
authors.lastname: Alecrim
authors.forename: Adriana de Carvalho
authors.initials: Ade C
authors.lastname: Mesquita
authors.forename: Gabriela Soares da Silva
authors.initials: GS
authors.lastname: Brito
authors.forename: Michele Gilvana
authors.initials: MG
authors.lastname: Junqueira
authors.forename: Daniela Batista
authors.initials: DB
authors.lastname: Leite
authors.forename: Cristina Valletta de
authors.initials: CV
authors.lastname: Carvalho
authors.forename: Ismael Dale Cotrim Guerreiro da
authors.initials: ID
authors.lastname: Silva
mesh_terms: D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A