title: [Expression of leptin and p-mTOR and their clinicopathological significance in human colon carcinoma].
abstract: OBJECTIVE
  To investigate the relationship between the expression of leptin, p-mTOR protein and the pathogenesis, development and clinicopathological features in colon carcinoma.
  
  
  METHODS
  The expression of leptin and p-mTOR protein was evaluated by immunohistochemical methods in 40 normal colon mucosas, 40 colon adenomatous polyps and 108 cases of colon carcinomas. The relationship between the staining pattern and clinicopathogical features was examined.
  
  
  RESULTS
  The positive rates of detection of leptin in normal colon mucosa, adenomatous polyps and colon carcinomas were 10% (4/40), 27.5% (11/40), and 71.3% (77/108), respectively; with significant differences among the three groups (P<0.05). The positive rates of p-mTOR protein in the normal colon mucosa, the adenomatous polyps, and the colon carcinomas were 2.5% (1/40), 20% (8/40), and 61.1% (66/108), respectively; with significant differences among the three groups (P<0.05). The expression of leptin and p-mTOR proteins were related to invasive depth, TNM stages, lymph node metastasis, distant metastasis and tumor differentiation (P<0.05), but not to age, sex, or site (P>0.05). In colon carcinoma tissues, leptin expression was positively correlated with p-mTOR expression (P<0.01).
  
  
  CONCLUSIONS
  Leptin and p-mTOR proteins may play important roles in the occurrence and development of colon carcinoma. The detection of leptin and p-mTOR may be helpful for evaluation of the prognosis of the patient with colon carcinoma.
authors.affiliation: Department of Pathology, The First Hospital of Changsha City, Changsha 410005, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Zhi
authors.initials: Z
authors.lastname: Duan
authors.forename: Qimei
authors.initials: Q
authors.lastname: Xu
authors.forename: Meiyan
authors.initials: M
authors.lastname: Wei
authors.forename: Lianghua
authors.initials: L
authors.lastname: Wang
authors.forename: Meizuo
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D018256:Adenomatous Polyps / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D003106:Colon / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010766:Phosphorylation; D011379:Prognosis; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D020738:Leptin; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases