title: [Malignant peripheral nerve sheath tumor associated with clear cell renal cell carcinoma - case report].
abstract: Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant counterpart to benign neurogenes tumors such as  schwannomas and neurofibromas and account for approximately 5-10 % of all soft tissue sarcomas. This neoplasm is also  referred to older designations as a malignant schwannoma, malignant neurilemmoma or neurogenic sarcoma.  A patient was a woman of 59 years old with a diagnosed malignant neurilemmoma, treated since 1993. Operated several  times and subjected to radiotherapy due to the local recurrence of the tumors located in the soft tissues of the back until  2002; Treated with chemotherapy (doxorubicin) and operated due to a lung metastases. The therapy resulted in a total  remission that lasted 12 months. In 2004 a new small tumor was diagnosed in the right lung, which had been followed up  until 2006. The patient did not give permission to a second surgery, treated with ifosfamide. In 2006 she was operated for  renal cell carcinoma of the left kidney. In 2009, due to a following progression of neurilemmoma and a worsening overall  condition, she was subsequently treated with a combination of gemcitabine and docetaxel. The treatment resulted in a slight  improvement, but was stopped due to complications (pancytopenia). In 2010 another progression of the disease occurred,  which resulted in pleural metastases and osteolytic lesions in the vertebrae (Th6 and L2).
authors.affiliation: Katedra i Klinika Pneumonologii Onkologii i Alergologii Uniwersytetu Medycznego w Lublinie. gryglicka@post.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Gryglicka
authors.forename: Irena
authors.initials: I
authors.lastname: Węgrzyn-Szkutnik
authors.forename: Janusz
authors.initials: J
authors.lastname: Milanowski
authors.forename: Sławomir
authors.initials: S
authors.lastname: Mandziuk
authors.forename: Ludmiła
authors.initials: L
authors.lastname: Grzybowska-Szatkowska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Surdyka
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Czekajska-Chehab
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zdunek
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery*; D059186:Chemoradiotherapy, Adjuvant; D018450:Disease Progression; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D008159:Lumbar Vertebrae; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000556:secondary* / Q000601:surgery*; D018317:Nerve Sheath Neoplasms / Q000628:therapy*; D009442:Neurilemmoma / Q000628:therapy*; D010997:Pleural Neoplasms / Q000556:secondary; D013125:Spinal Neoplasms / Q000556:secondary; D013904:Thoracic Vertebrae