title: Systemic therapy in the management of metastatic or advanced salivary gland cancers.
abstract: Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.
authors.affiliation: Department of medical oncology, Salah Azaiez Institute, Boulevard du 9 Avril, Bab Saadoun Tunis, 1006, Tunisia. aymen.lagha@hotmail.com
authors.forename: Aymen
authors.initials: A
authors.lastname: Lagha
authors.forename: Nesrine
authors.initials: N
authors.lastname: Chraiet
authors.forename: Mouna
authors.initials: M
authors.lastname: Ayadi
authors.forename: Sarra
authors.initials: S
authors.lastname: Krimi
authors.forename: Bassem
authors.initials: B
authors.lastname: Allani
authors.forename: Hela
authors.initials: H
authors.lastname: Rifi
authors.forename: Henda
authors.initials: H
authors.lastname: Raies
authors.forename: Amel
authors.initials: A
authors.lastname: Mezlini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D012468:Salivary Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal