title: Application of the piecewise rational quadratic interpolant to the AUC calculation in the bioavailability study.
abstract: This study presents an application of the piecewise rational quadratic interpolant to the AUC calculation in the bioavailability study. The objective of this work is to find an area under the plasma concentration-time curve (AUC) for multiple doses of salbutamol sulfate sustained release tablets (Ventolin oral tablets SR 8 mg, GSK, Pakistan) in the group of 24 healthy adults by using computational mathematics techniques. Following the administration of 4 doses of Ventolin tablets 12 hourly to 24 healthy human subjects and bioanalysis of obtained plasma samples, plasma drug concentration-time profile was constructed. The approximated AUC was computed by using computational mathematics techniques such as extended rectangular, extended trapezium and extended Simpson's rule and compared with exact value of AUC calculated by using software - Kinetica to find best computational mathematics method that gives AUC values closest to exact. The exact values of AUC for four consecutive doses of Ventolin oral tablets were 150.58, 157.81, 164.41 and 162.78 ngxh/mL while the closest approximated AUC values were 149.24, 157.33, 164.25 and 162.28 ngxh/mL, respectively, as found by extended rectangular rule. The errors in the approximated values of AUC were negligible. It is concluded that all computational tools approximated values of AUC accurately but the extended rectangular rule gives slightly better approximated values of AUC as compared to extended trapezium and extended Simpson's rules.
authors.affiliation: Department of Mathematics, the Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Khalid P
authors.initials: KP
authors.lastname: Akhter
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
authors.forename: Shujaat Ali
authors.initials: SA
authors.lastname: Khan
authors.forename: Munazza
authors.initials: M
authors.lastname: Ramzan
authors.forename: Ishrat
authors.initials: I
authors.lastname: Shafi
authors.forename: Burhana
authors.initials: B
authors.lastname: Muryam
authors.forename: Zafar
authors.initials: Z
authors.lastname: Javed
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D010154:Pakistan; D012984:Software; D013607:Tablets
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D000420:Albuterol