title: Biofunctional properties of caseinophosphopeptides in the oral cavity.
abstract: Caseinophosphopeptides (CPPs), bioactive peptides released from caseins, have the ability to enhance bivalent mineral solubility. This is relevant to numerous biological functions in the oral cavity (promotion of tooth enamel remineralisation, prevention of demineralisation and buffering of plaque pH). Therefore, CPPs may play a positive role as prophylactic agents for caries, enamel erosion and regression of white spot lesions. Most in vitro and in situ studies demonstrate strong evidence for the bioactivity of CPPs in the oral cavity. Nevertheless, relatively little is known concerning their use as adjuvants for oral health and more particularly regarding their long-term effects on oral health.
authors.affiliation: Department of Life Sciences and Food for Health Ireland (FHI), University of Limerick, Limerick, Ireland.
authors.forename: A B
authors.initials: AB
authors.lastname: Nongonierma
authors.forename: R J
authors.initials: RJ
authors.lastname: Fitzgerald
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000378:metabolism; D002364:Caseins / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003807:Dentin Sensitivity / Q000517:prevention & control; D004357:Drug Synergism; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D010748:Phosphopeptides / Q000737:chemistry / Q000378:metabolism*; D014077:Tooth Erosion / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002130:Calcium Phosphates; D002364:Caseins; D010748:Phosphopeptides; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C020243:calcium phosphate; D005459:Fluorides