title: FGF-23 removal is improved by on-line high-efficiency hemodiafiltration compared to conventional high flux hemodialysis.
abstract: BACKGROUND
  Reducing circulating levels of fibroblast growth factor-23 (FGF-23) in patients on renal replacement therapy (RRT) could appear as an appealing approach for cardiovascular events prevention. The purpose of our study was to compare the clearance of FGF-23 between high flux hemodialysis (HD) and on-line hemodiafiltration (OL-HDF) procedures.
  
  
  METHODS
  Fifty-three patients were included in the HD group while 32 patients were included in the OL-HDF group. Serum pre- and post-dialysis FGF-23 levels were measured using a 2nd generation Human FGF-23 (C-Term) ELISA kit.
  
  
  RESULTS
  Mean FGF-23 reduction rates were significantly higher in OL-HDF (55.7 ± 25.2%) versus HD (36.2 ± 28.6%) groups (P=.0001), as were calculated FGF-23 clearances (P=.015) and Kt/V-FGF-23 (P=.001). Overall, post-treatment FGF-23 levels were significantly lower than pre-treatment values in both groups (P<.01).
  
  
  CONCLUSIONS
  OL-HDF achieves higher FGF-23 removal over high flux HD.
authors.affiliation: Laboratory of Biochemistry, Montpellier University Hospital, Montpellier, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Patrier
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.forename: Alexandre
authors.initials: A
authors.lastname: Granger Vallée
authors.forename: Lotfi
authors.initials: L
authors.lastname: Chalabi
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D004867:Equipment Design; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D016014:Linear Models; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D011446:Prospective Studies; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000628:therapy*; D013450:Sulfones; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C000717427:FGF23 protein, human; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23