title: The immunoglobulin light chain locus of the turkey, Meleagris gallopavo.
abstract: To date, most jawed vertebrate species encode more than one immunoglobulin light (IgL) chain isotypes. It has been shown that several bird species (chickens, white Pekin or domestic duck, and zebra finches) exclusively express lambda isotype. We analyze here the genomic organization of another bird species turkey IgL genes based on the recently released genome data. The turkey IgL locus located on chromosome 17 spans approximately 75.2kb and contains a single functional V(λ) gene, twenty V(λ) pseudogenes, and a single functional J(λ)-C(λ) block. These data suggest that the genomic organization of bird IgL chain genes seems to be conserved. Ten cDNA clones from turkey Igλ chain containing almost full-length V(λ), J(λ) and C(λ) segments were acquired. The comparison of V(λ) cDNA sequences to all the germline V(λ) segments suggests that turkey species may be generating IgL chain diversity by gene conversion and somatic hypermutation like the chicken. This study provides insights into the immunoglobulin light chain genes in another bird species.
authors.affiliation: Department of Basic Immunology, Xinxiang Medical University, Jinsui Street, Xinxiang 453003, PR China. baoyonghua2005@yahoo.com.cn
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Bao
authors.forename: Sun
authors.initials: S
authors.lastname: Wu
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Song
authors.forename: Chunyang
authors.initials: C
authors.lastname: Xu
authors.forename: Bohong
authors.initials: B
authors.lastname: Xie
authors.forename: Yongchen
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D050439:Genes, Immunoglobulin Light Chain; D056426:Genetic Loci; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007133:Immunoglobulin Joining Region / Q000235:genetics; D008969:Molecular Sequence Data; D014422:Turkeys / Q000276:immunology*
chemical_list: D007127:Immunoglobulin Constant Regions; D007133:Immunoglobulin Joining Region