title: [To investigate the strategy of Chinese medicine for prevention and treatment of atherosclerosis based on vascular aging].
abstract: Atherosclerosis, a chronic degenerative disease mainly attacks the middle-aged and the aged population as they grow old. Anti-angiocellular aging has gradually become a new strategy for atherosclerosis. In the process of atherosclerosis developing, endothelial cell renewing is speeding. Various biological function disorders that induce blood vessel aging emerge, which leads to changes of the telomere and telomerase, resulting in aged endothelial cells and dysfunction. Telomere and telomerase may play key roles in the etiological factors such as inflammation and AS plaque. In our previous work we have found that Chinese compounds with Shen invigorating effects could not only obviously ameliorate the symptoms and functions of the senility, but also show significant effects on restraining atherosclerosis. We should actively study the mechanisms of Chinese medicine for treating atherosclerosis from Shen, and the mechanisms of Shen invigorating compounds for regulating angiocellular aging through the telomere pathway, thus providing evidence for establishing vascular cell aging based atherosclerosis prevention and treatment strategies by Chinese medicine.
authors.affiliation: Shanghai Geriatrics Institute of Chinese Medicine, Shanghai (200031).
authors.forename: Ding-Zhu
authors.initials: DZ
authors.lastname: Shen
authors.forename: Chuan
authors.initials: C
authors.lastname: Chen
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Chi
mesh_terms: D000375:Aging; D050197:Atherosclerosis / Q000473:pathology* / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D008516:Medicine, Chinese Traditional