title: Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides.
abstract: Two new daphnane diterpenoids (1 and 2), together with four known analogues (3-6) were isolated from Trigonostemon xyphophylloides. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 were evaluated for in vitro cytotoxic activities against the SPCA-1 (human lung cancer) and BEL-7402 (human hepatocellular carcinoma) cancer cell lines. Trigoxyphin I (2) showed modest cytotoxicity against two tumor cell lines.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yang
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.forename: Liu-Qing
authors.initials: LQ
authors.lastname: Yang
authors.forename: Chang-Ri
authors.initials: CR
authors.lastname: Han
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wu
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Li
authors.forename: Bing-Yan
authors.initials: BY
authors.lastname: Zou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C574996:trigoxyphin H; C574997:trigoxyphin I