title: Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D.
abstract: Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental to understand and control the processes regulating cell fate and cell function. From the ill-defined complexity to the controlled simplicity, we discuss the different strategies that are being carried out by scientists worldwide to achieve the latest advances in the sophistication of three-dimensional (3D) scaffolds, stressing their impact on cell biology, tissue engineering and regenerative medicine. Synthetic and naturally derived polymers like polyethylene glycol, alginate, agarose, etc., together with micro- and nanofabrication techniques are allowing the creation of 3D models where biophysical and biochemical variables can be modified with high precision, orthogonality and even in real-time.
authors.affiliation: NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, School of Pharmacy, Vitoria, Spain.
authors.forename: Edorta
authors.initials: E
authors.lastname: Santos
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Hernández
authors.forename: José Luis
authors.initials: JL
authors.lastname: Pedraz
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
mesh_terms: D001672:Biocompatible Materials; D011108:Polymers; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011108:Polymers