title: Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.
abstract: This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC(50) values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Limoges, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Drogat
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.forename: Caroline
authors.initials: C
authors.lastname: Le Morvan
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Bégaud-Grimaud
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
authors.forename: Vincent
authors.initials: V
authors.lastname: Sol
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002482:Cellulose / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011094:Polyethyleneimine / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; C072905:chlorin p6; D011094:Polyethyleneimine; D002482:Cellulose