title: [Study of the serum concentrations of acetaminophen overdose].
abstract: Acetaminophen (APAP) is a commonly used nonsteroidal analgesic because it is considered safe. However, APAP is a major cause of acute poisoning because of its easy availability. APAP overdose causes hepatic failure. A previous study reported a case of death occurring 3-4 days after APAP overdose. Serum APAP level is an index for administration of N-acetyl-L-cysteine (NAC). We investigated cases of APAP overdose to determine the correlation between serum APAP level and estimated APAP dosage, NAC medication, hepatic failure, etc. In one case, we found that the use of estimated APAP dosage alone led to inappropriate NAC medication. Moreover, there were cases in which serum APAP level increased 4 hr after APAP overdose. Repeated cases of APAP overdose suggested that the presence of NAC medication caused a difference in liver function test values.
authors.affiliation: Department of Pharmacy, Yamagata University Hospital.
authors.forename: Aya
authors.initials: A
authors.lastname: Tominaga
authors.forename: Teiko
authors.initials: T
authors.lastname: Toyoguchi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Hosoya
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Ken
authors.initials: K
authors.lastname: Iseki
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000097:blood* / Q000506:poisoning; D000111:Acetylcysteine / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000097:blood* / Q000506:poisoning; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D063487:Prescription Drug Misuse; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D000111:Acetylcysteine