title: Primary thyroid angiosarcoma: an unusual localization.
abstract: The finding of thyroid nodules is a very common occurrence in routine clinical practice. Approximately 5% to 7% of the entire population have thyroid nodules. Vascular lesions are one of the most controversial issues in thyroid pathology. These include benign lesions such as hemangiomas and, rarely, malignant tumors such as angiosarcomas or undifferentiated angiosarcomatoid carcinomas. In particular, angiosarcoma of the thyroid gland is a rare, highly aggressive malignant vascular tumor and in Italy the greatest geographical incidence of this lesion is witnessed near the Alps. Here, a case of thyroid angiosarcoma in a 71-year-old man with a history of goiter for about 20 years is described. The unusual localization of this lesion, the difficulties in reaching a definitive diagnosis for this particular histological type of primary tumor and a history of long-standing multinodular goiter in thyroid of an older man from outside the Alpine region prompted us to report this case of thyroid angiosarcoma mainly to discuss surgical, histopathological and immunohistochemical features.
authors.affiliation: Department of Gerontology, Geriatry and Metabolic Diseases, UOC of General and Geriatric Surgery, School of Medicine, Second University of the Study of Naples, Naples, Italy. pasquale.petronella@unina2.it
authors.forename: Pasquale
authors.initials: P
authors.lastname: Petronella
authors.forename: Marco
authors.initials: M
authors.lastname: Scorzelli
authors.forename: Rossella
authors.initials: R
authors.lastname: Luise
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iannaci
authors.forename: Patrizia
authors.initials: P
authors.lastname: Sapere
authors.forename: Marco
authors.initials: M
authors.lastname: Ferretti
authors.forename: Rosaria Maria Anna
authors.initials: RM
authors.lastname: Costanzo
authors.forename: Fulvio
authors.initials: F
authors.lastname: Freda
authors.forename: Silvestro
authors.initials: S
authors.lastname: Canonico
authors.forename: Raffaele
authors.initials: R
authors.lastname: Rossiello
mesh_terms: D017809:Fatal Outcome; D006394:Hemangiosarcoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery