title: Characterization, molecular modeling and antimicrobial activity of metal complexes of tridentate Schiff base derived from 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione and 2-aminophenol.
abstract: Metal complexes of Ni(II), Co(II), Cd(II), VO(IV) and UO(2)(VI) as well as several Cu(II) salts, including Cl(-),NO(3)(-),AcO(-),ClO(4)(-) and SO(4)(-2) with a tridentate O(2)N donor Schiff base ligand (H(2)L), synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 2-aminophenol, were prepared and characterized on the basis of elemental analyses, spectral, magnetic, molar conductance and thermal gravimetric analysis. Square planar, tetrahedral and octahedral geometries have been assigned to the prepared complexes. Molecular parameters of the ligand and its metal complexes have been calculated and correlated with the experimental data, and the changes of bond lengths are linearly correlated with IR data. The antimicrobial activities of the synthesized compounds were tested in vitro against the sensitive organisms Staphylococcus aureus as Gram positive bacteria, Proteus vulgaris as Gram negative bacteria and Candida albicans as fungus strain, and the results are discussed.
authors.affiliation: Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo 11711, Egypt. omima_adly@yahoo.com
authors.forename: Omima M I
authors.initials: OM
authors.lastname: Adly
mesh_terms: D000627:Aminophenols / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013843:Thiazines / Q000737:chemistry*
chemical_list: C575667:5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione; D000627:Aminophenols; D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D013843:Thiazines; C027667:2-aminophenol; D004121:Dimethyl Sulfoxide