title: Effects of lipoprotein-associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients.
abstract: Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum Lp-PLA2 mass levels on arginase/nitric oxide (NO) pathway as a cardiovascular risk marker in hemodialysis (HD) patients. Forty-three HD patients and 15 healthy subjects were included in this study. Lipid profile, high sensitivity C-reactive protein (hs-CRP), albumin, creatinine, body mass index (BMI), Lp-PLA2 and total nitrite levels, and arginase activity were determined in serum samples from patients and control subjects. Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients. We conclude that elevated Lp-PLA2 mass levels may contribute to impaired arginase/NO pathway in HD patients and that increased the arginase activity and Lp-PLA2 mass levels with decreased total nitrite levels seem to be useful biochemical markers in terms of reflecting endothelial dysfunction and associated cardiovascular risks in HD patients.
authors.affiliation: Department of Medical Biochemistry, School of Medicine, Unıiversity of Eskişehir Osmangazi, Eskişehir, Turkey.
authors.forename: Ayşegül Korkmaz
authors.initials: AK
authors.lastname: Tektaş
authors.forename: Sema
authors.initials: S
authors.lastname: Uslu
authors.forename: Ahmet Uğur
authors.initials: AU
authors.lastname: Yalçin
authors.forename: Garip
authors.initials: G
authors.lastname: Sahin
authors.forename: Gökhan
authors.initials: G
authors.lastname: Temiz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kara
authors.forename: Halide Edip
authors.initials: HE
authors.lastname: Temel
authors.forename: Emine Sütken
authors.initials: ES
authors.lastname: Demirkan
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Colak
authors.forename: Omer
authors.initials: O
authors.lastname: Colak
mesh_terms: D001119:Arginase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood*; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D054467:Phospholipases A2 / Q000097:blood*; D006435:Renal Dialysis; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D008055:Lipids; D009573:Nitrites; D012709:Serum Albumin; D009569:Nitric Oxide; D002097:C-Reactive Protein; D003404:Creatinine; D054467:Phospholipases A2; D001119:Arginase