title: Amyloid deposition after cerebral hypoperfusion: evidenced on [(18)F]AV-45 positron emission tomography.
abstract: Animal studies have shown that cerebral hypoperfusion may be associated with amyloid plaque accumulation. Amyloid plaque is known to be associated with dementia and [(18)F]AV-45 is a positron emission tomography (PET) ligand that binds to extracelluar plaques. We hypothesized that demented patients with cerebral hypoperfusion may have increased [(18)F]AV-45 uptake. Five demented patients with cerebral hypoperfusion due to unilateral carotid artery stenosis (CAS) were examined with [(18)F]AV-45 PET, and the results were compared with six elderly controls. The standard uptake value ratio (SUVR) of each region of interest (ROI) was created using whole cerebellum as the reference region. All subjects underwent magnetic resonance imaging (MRI) for obtaining structural information. Patients with dementia and unilateral CAS had a higher global [(18)F]AV-45 SUVR (1.34 ± 0.06) as compared with controls (1.10 ± 0.04, p=0.0043), especially over the frontal, temporal, precuneus, anterior cingulate and occipital regions. The statistical distribution maps revealed a significantly increased [(18)F]AV-45 SUVR in the medial frontal, caudate, thalamus, posterior cingulate, occipital and middle and superior temporal regions ipsilateral to the side of CAS (p<0.01). The present study found that cerebral [(18)F]AV-45 binding is increased in demented patients with CAS, and its distribution is lateralized to the CAS side, suggesting that amyloid-related dementia may occur under cerebral hypoperfusion.
authors.affiliation: Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. drkuolun@adm.cgmh.org.tw
authors.forename: Kuo-Lun
authors.initials: KL
authors.lastname: Huang
authors.forename: Kun-Ju
authors.initials: KJ
authors.lastname: Lin
authors.forename: Meng-Yang
authors.initials: MY
authors.lastname: Ho
authors.forename: Yeu-Jhy
authors.initials: YJ
authors.lastname: Chang
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Chang
authors.forename: Shiaw-Pyng
authors.initials: SP
authors.lastname: Wey
authors.forename: Chia-Ju
authors.initials: CJ
authors.lastname: Hsieh
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
authors.forename: Ing-Tsung
authors.initials: IT
authors.lastname: Hsiao
authors.forename: Tsong-Hai
authors.initials: TH
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D003704:Dementia / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D000682:Amyloid