title: Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population.
abstract: What's known on the subject? and What does the study add? The association between subjects with the genetic variation of 8q24 and the risk of development of prostate cancer in Korean men was found. As a result of haplotype analysis, [AGC] and [CTA] carriers showed a significant association with prostate cancer risk. This is clinically meaningful as an initial study on genetic susceptibility to prostate cancer in Korean men and the first report of 8q24 haplotypes in an Asian population.
  
  
  OBJECTIVE
  To determine the association between genetic variation of 8q24 with prostate cancer risk in Korean men.
  
  
  METHODS
  With a hospital-based case-control study design, we enrolled 194 patients with prostate cancer and 169 healthy controls from visitors for cancer screening. DNA samples were obtained from peripheral blood for the analysis of single nucleotide polymorphisms (SNPs). Three SNPs of 8q24, including rs16901979, rs6983267, and rs1447295, were genotyped on cases and controls.
  
  
  RESULTS
  The subjects with the rs1447295 CA or AA genotype had a higher risk of prostate cancer than the CC genotype. The A allele at SNP rs1447295 was associated with the incidence of prostate cancer. The rs16901979 CA genotype carriers had a higher risk of prostate cancer than the CC genotype. Individuals with the [AGC] and [CTA] haplotypes had a significantly increased risk of prostate cancer compared with the [CTC] haplotype ([AGC] with adjusted odds ratio [OR] 1.79; 95% confidence interval [CI] 1.09-2.96; P = 0.022; [CTA] with adjusted OR 5.17; 95% CI 2.40-11.15; P < 0.001).
  
  
  CONCLUSIONS
  The genetic variation of 8q24 is associated with the risk of prostate cancer in Korean men. Individuals with the [AGC] and [CTA] haplotypes had a significant association with prostate cancer risk.
authors.affiliation: Center for Prostate Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Jae Y
authors.initials: JY
authors.lastname: Joung
authors.forename: Sohee
authors.initials: S
authors.lastname: Park
authors.forename: Hyekyoung
authors.initials: H
authors.lastname: Yoon
authors.forename: Sang J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Weon S
authors.initials: WS
authors.lastname: Park
authors.forename: Ho K
authors.initials: HK
authors.lastname: Seo
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Chung
authors.forename: Sook-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Hong
authors.forename: Yeon-Su
authors.initials: YS
authors.lastname: Lee
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
authors.forename: Kang H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000235:genetics*; D056910:Republic of Korea; D012306:Risk