title: Tuberculosis of spine: neurological deficit.
abstract: The most dreaded neurological complications in TB spine occur in active stage of disease by mechanical compression, instability and inflammation changes, while in healed disease, these occur due to intrinsic changes in spinal cord secondary to internal salient in long standing kyphotic deformity. A judicious combination of conservative therapy and operative decompression when needed should form a comprehensive integrated course of treatment for TB spine with neurological complications. The patients showing relatively preserved cord with evidence of edema/myelitis with predominantly fluid collection in extradural space on MRI resolve on non-operative treatment, while the patients with extradural compression of mixed or granulomatous nature showing entrapment of spinal cord should be undertaken for early surgical decompression. The disease focus should be debrided with removal of pus caseous tissue and sequestra. The viable bone should only be removed to decompress the spinal cord and resultant gap should be bridged by bone graft. The preserved volume of spinal cord with edema/myelitis and wet lesion on MRI usually would show good neural recovery. The spinal cord showing myelomalacia with reduced cord volume and dry lesion likely to show a poor neural recovery. The internal kyphectomy is indicated for paraplegia with healed disease. These cases are bad risk for surgery and neural recovery. The best form of treatment of late onset paraplegia is the prevention of development of severe kyphosis in initial active stage of disease.
authors.affiliation: Department of Orthopaedics, Guru Teg Bahadur Hospital, University College of Medical Sciences, Dilshad Garden, Delhi, India. dranilkjain@gmail.com
authors.forename: Anil K
authors.initials: AK
authors.lastname: Jain
authors.forename: Jaswant
authors.initials: J
authors.lastname: Kumar
mesh_terms: D019299:Decompression, Surgical; D006801:Humans; D010264:Paraplegia / Q000209:etiology* / Q000601:surgery; D013117:Spinal Cord Compression / Q000382:microbiology / Q000601:surgery; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000601:surgery