title: Low testosterone levels are related to poor prognosis factors in men with prostate cancer prior to treatment.
abstract: What's known on the subject? and What does the study add? Prostate growth is ruled by testosterone. Nevertheless, the paradigm that high testosterone levels induce prostate cancer development or lead to a poor prognosis in prostate cancer is not supported by evidence. A growing number of studies suggest that, on the contrary, low testosterone levels are related to poor prognosis features in prostate cancer such as higher prostate-specific antigen or higher Gleason score. Our experience shows that testosterone levels are related to risk of progression of prostate cancer - those men with lower testosterone levels are at higher risk of progression of their prostate cancer after treatment delivery.
  
  
  OBJECTIVE
  • Low testosterone levels have been related to a higher diagnosis of prostate cancer (PCa). Hormonal levels have been related to poor prognosis factors in men with PCa, mainly after radical prostatectomy. • Our aim was to determine the relationship between hormonal levels and PCa prognosis factors in men with PCa prior to the onset of treatment.
  
  
  METHODS
  • We prospectively analysed 137 males diagnosed in our centre with PCa with 5+5 core prostate biopsies from February 2007 to December 2009. • As part of our clinical protocol, we performed hormonal determination (testosterone and sex hormone binding globulin) following International Society of Andrology, International Society for the Study of the Aging Male and European Association of Urology recommendations. • Free testosterone and bioavailable testosterone were calculated using Vermeulen's formula. • Age, prostate-specific antigen (PSA), free to total PSA, PSA density, number of previous biopsies, digital rectal examination staging, Gleason score, percentage of tumour in the biopsy sample, bilaterality of the tumour and risk of progression group were prospectively recorded.
  
  
  RESULTS
  • Higher testosterone levels were related to lower digital rectal examination staging (P= 0.02) and lower PSA level (P= 0.05). Higher testosterone was not related to lower Gleason score (P= 0.08). • Testosterone was inversely related to PCa bilaterality (P < 0.01) and percentage of tumour in the biopsy (P < 0.01). • High testosterone levels were found in patients allocated to the low risk of progression group and inversely (P= 0.03). • In multivariate analysis, higher age and lower testosterone were related to higher D'Amico risk of progression.
  
  
  CONCLUSIONS
  • Patients with PCa and lower testosterone levels have poor prognosis factors and higher tumour burden before treatment onset. These findings reinforce the idea that low testosterone levels pretreatment are related to a poor prognosis in PCa.
authors.affiliation: Urology Department, Hospital Clinic de Barcelona, Barcelona, Spain. edu_garcia_cruz@yahoo.com
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Cruz
authors.forename: Marta
authors.initials: M
authors.lastname: Piqueras
authors.forename: Jorge
authors.initials: J
authors.lastname: Huguet
authors.forename: Lluis
authors.initials: L
authors.lastname: Peri
authors.forename: Laura
authors.initials: L
authors.lastname: Izquierdo
authors.forename: Mireia
authors.initials: M
authors.lastname: Musquera
authors.forename: Agustin
authors.initials: A
authors.lastname: Franco
authors.forename: Ricardo
authors.initials: R
authors.lastname: Alvarez-Vijande
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Ribal
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcaraz
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D003131:Combined Modality Therapy; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D011379:Prognosis; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology* / Q000601:surgery; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D012307:Risk Factors; D013739:Testosterone / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013739:Testosterone; D017430:Prostate-Specific Antigen