title: Complexity generation during natural product biosynthesis using redox enzymes.
abstract: Redox enzymes such as FAD-dependent and cytochrome P450 oxygenases play indispensible roles in generating structural complexity during natural product biosynthesis. In the pre-assembly steps, redox enzymes can convert garden variety primary metabolites into unique starter and extender building blocks. In the post-assembly tailoring steps, redox cascades can transform nascent scaffolds into structurally complex final products. In this review, we will discuss several recently characterized redox enzymes in the biosynthesis of polyketides and nonribosomal peptides.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
mesh_terms: D001688:Biological Products / Q000378:metabolism*; D004798:Enzymes / Q000378:metabolism*; D010084:Oxidation-Reduction; D046908:Peptide Biosynthesis, Nucleic Acid-Independent; D061065:Polyketides / Q000378:metabolism
chemical_list: D001688:Biological Products; D004798:Enzymes; D061065:Polyketides