title: Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles.
abstract: Synthesis of triazole based unnatural amino acids and β-amino triazoles has been described via a stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with a triazole side chain.
authors.affiliation: Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, MS 443, Cincinnati, Ohio 45268, USA.
authors.forename: R B Nasir
authors.initials: RB
authors.lastname: Baig
authors.forename: Rajender S
authors.initials: RS
authors.lastname: Varma
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis*; D019810:Sodium Azide / Q000737:chemistry; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D000596:Amino Acids; D013451:Sulfonic Acids; D014230:Triazoles; D019810:Sodium Azide