title: Genome-based bioprospecting of microbes for new therapeutics.
abstract: Bioprospecting of natural sources for new medicines has a long and successful history, exemplified by the fact that over 50% of all drugs currently on the market are either derived from or inspired by natural products. However, development of new natural product-based therapeutics has been on the decline over the past 20 years, mainly owing to frequent re-discovery of already known compounds coupled with high costs for screening, characterization and development. With the onset of the genomic era allowing rapid sequencing and analysis of bacterial and fungal genomes, it became evident that these organisms possess 'hidden treasures' in the form of gene clusters potentially governing biosynthesis of novel biologically active compounds. This review highlights current progress in mining for and expression of these gene clusters, which may revolutionize the drug discovery pipelines in the near future.
authors.affiliation: Department of Biotechnology, Norwegian University of Science and Technology, Trondeim, Norway. sergey.zotchev@nt.ntnu.no
authors.forename: Sergey B
authors.initials: SB
authors.lastname: Zotchev
authors.forename: Olga N
authors.initials: ON
authors.lastname: Sekurova
authors.forename: Leonard
authors.initials: L
authors.lastname: Katz
mesh_terms: D001688:Biological Products / Q000302:isolation & purification / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D016680:Genome, Bacterial / Q000235:genetics*; D016681:Genome, Fungal / Q000235:genetics*; D023281:Genomics; D053858:Metabolic Networks and Pathways / Q000235:genetics; D005810:Multigene Family / Q000235:genetics; D058615:Synthetic Biology; D015854:Up-Regulation
chemical_list: D001688:Biological Products