title: Comparison of ictal electroencephalogram between ultrabrief- and brief-pulse right unilateral electroconvulsive therapy: a multitaper jackknife analysis.
abstract: OBJECTIVE
  Characterization of the ictal electroencephalogram (EEG) generated during ultrabrief pulse electroconvulsive therapy (ECT) is important to progress its use in routine ECT practice particularly in indicating treatment efficacy. The study compared 2- to 5-Hz and 5.2- to 13-Hz bands of the ictal EEG signal between brief- and ultrabrief-pulse ECT.
  
  
  METHODS
  Twenty-five patients with major depression were randomized to brief- (1 millisecond [ms]) and ultrabrief-pulse (0.3 ms) right unilateral ECT. In sessions 2 to 8, when patients in either group received 6 times threshold ECT, right and left frontal ictal EEG between ultrabrief (n = 60) and brief pulse (n = 63) were compared. Electroencephalographic spectra from 2- to 5-Hz and 5.2- to 13-Hz bands in the mid and postictal phases were subjected to multitaper jackknife analysis of spectral power density (μV/Hz) and its SD or "regularity" (μV/Hz), peak spectral frequency (Hz), and its standard deviation (SD) or regularity (Hz). Linear mixed-effect models were used to compare the outcomes.
  
  
  RESULTS
  In ultrabrief ECT, spectral power density and its SD were significantly smaller within the mid seizure of both bands, whereas peak frequency and its SD were similar. Postseizure suppression of spectral power density of both bands was similar in either treatments.
  
  
  CONCLUSIONS
  Lower spectral power densities were noted with ultrabrief-pulse ECT vis-a-vis brief-pulse ECT. However, in ultrabrief pulse ECT, regularity measures and postseizure suppression were comparable to brief-pulse ECT.
authors.affiliation: Cumberland Hospital, Westmead, Sydney, Australia. Prashanth_Mayur@wsahs.nsw.gov.au
authors.forename: Prashanth
authors.initials: P
authors.lastname: Mayur
authors.forename: Anthony
authors.initials: A
authors.lastname: Harris
authors.forename: Chris
authors.initials: C
authors.lastname: Rennie
authors.forename: Karen
authors.initials: K
authors.lastname: Byth
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D003710:Demography; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000628:therapy; D004565:Electroconvulsive Therapy; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012640:Seizures / Q000503:physiopathology