title: Estrogen-related receptor alpha: an orphan finds a family.
abstract: Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.
authors.affiliation: Masonic Cancer Center, Departments of Medicine and Pharmacology, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
authors.forename: Aleksandra M
authors.initials: AM
authors.lastname: Ochnik
authors.forename: Douglas
authors.initials: D
authors.lastname: Yee
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D005260:Female; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016601:RNA-Binding Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016601:RNA-Binding Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D017526:Receptor, IGF Type 1; D011960:Receptors, Estrogen; D014157:Transcription Factors; D000097983:ERRalpha Estrogen-Related Receptor; C486497:PPARGC1A protein, human; C455622:PPARGC1B protein, human; C508053:ERBB2 protein, human