title: Complete genome sequence of an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus.
abstract: JXA1-P170 is an overattenuated highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) that has been passaged in vitro 170 times. Vaccination with JXA1-P170 cannot protect pigs against JXA1 challenge. Compared with the parental virus JXA1, JXA1-P170 contains 1 nucleotide (nt) deletion and 113 nt mutations leading to 59 amino acid substitutions. Here we announce the first complete genome sequence of the overattenuated HP-PRRSV.
authors.affiliation: Veterinary Diagnostic Laboratory, China Animal Disease Control Center, Beijing, People's Republic of China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Wu
authors.forename: Nanhua
authors.initials: N
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cao
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Deng
authors.forename: Lilin
authors.initials: L
authors.lastname: Wang
authors.forename: Xiuling
authors.initials: X
authors.lastname: Yu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.forename: Jishu
authors.initials: J
authors.lastname: Shi
authors.forename: Kegong
authors.initials: K
authors.lastname: Tian
mesh_terms: D000818:Animals; D016679:Genome, Viral; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017354:Point Mutation; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D012692:Serial Passage; D013552:Swine; D014774:Virulence
chemical_list: D012367:RNA, Viral