title: Effect of Chrysanthemi borealis flos on atopic dermatitis induced by 1-chloro 2,4-dinitrobenzene in NC/Nga mouse.
abstract: The flower of Chrysanthemum boreale has traditionally been used for treatment of various inflammatory disease including atopic dermatitis (AD). However, its action on AD is unclear. Therefore, we investigated the effect of CB on AD using NC/Nga mice as an AD model. The effect of CB on 1-Chloro-2,4-dinitrobenzene (DNCB) induced NC/Nga mice was evaluated by examining skin symptom severity, itching behavior, ear thickness, levels of serum Immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α), and interleukin-4 (IL-4), skin histology. The CB significantly reduced the total clinical severity score, itching behavior, ear thickness and the level of serum IgE in AD mouse model. CB not only decreased TNF-α but also IL-4. These results suggest that CB may be a potential therapeutic modality for AD.
authors.affiliation: Department of Herbology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea.
authors.forename: Gabsik
authors.initials: G
authors.lastname: Yang
authors.forename: Kyungjin
authors.initials: K
authors.lastname: Lee
authors.forename: Duck-Gun
authors.initials: DG
authors.lastname: An
authors.forename: Mi-Hwa
authors.initials: MH
authors.lastname: Lee
authors.forename: In-Hye
authors.initials: IH
authors.lastname: Ham
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Choi
mesh_terms: D000818:Animals; D031202:Chrysanthemum / Q000737:chemistry*; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004137:Dinitrochlorobenzene / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D015847:Interleukin-4 / Q000097:blood / Q000276:immunology; D007509:Irritants / Q000009:adverse effects / Q000494:pharmacology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012867:Skin / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
chemical_list: D004137:Dinitrochlorobenzene; D007509:Irritants; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007073:Immunoglobulin E