title: Network medicine strikes a blow against breast cancer.
abstract: Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
authors.affiliation: Biotech Research and Innovation Center, University of Copenhagen, Denmark. janine.erler@bric.ku.dk
authors.forename: Janine T
authors.initials: JT
authors.lastname: Erler
authors.forename: Rune
authors.initials: R
authors.lastname: Linding