title: Subfertility in women with familial Mediterranean fever.
abstract: OBJECTIVE
  The aim of this study was to examine the causes and different modalities used for management of subfertile patients with familial Mediterranean fever (FMF).
  
  
  METHODS
  The study comprised of 74 infertile women with FMF. All patients were diagnosed as having FMF. All patients underwent a full infertility work-up. They were scheduled to expectant treatment, ovulation induction and timed intercourse, intrauterine insemination or intracytoplasmic sperm injection.
  
  
  RESULTS
  Anovulation was reported in 18 patients (24.32%). Anovulation was due to polycystic ovary syndrome in 12 (16.22%) cases and due to other causes in six patients (8.11%). Excessive clear peritoneal fluid was present in 56 (57.67%) and male-factor infertility was present in 14 couples (18.91%). Ovulation induction and timed intercourse was adopted for a maximum of six cycles and intrauterine insemination for three cycles. In vitro fertilization/intracytoplasmic sperm injection was needed in six cases using standard long agonist protocol. Twenty-six women became pregnant.
  
  
  CONCLUSIONS
  The causes of infertility in patients with FMF are not different from those expected in the general population. Treatment of the problem should be causal, adopting the conventional lines of treatment up to in vitro fertilization/intracytoplasmic sperm injection when appropriate. Colchicine is the treatment of choice and it is important to use it in its proper doses to control the disease.
authors.affiliation: Department of Obstetrics & Gynecology, Mansoura University, Mansoura, Egypt.
authors.forename: Abdelhady
authors.initials: A
authors.lastname: Zayed
authors.forename: Hanan
authors.initials: H
authors.lastname: Nabil
authors.forename: Omnia
authors.initials: O
authors.lastname: State
authors.forename: Ahmed
authors.initials: A
authors.lastname: Badawy
mesh_terms: D000293:Adolescent; D000328:Adult; D003078:Colchicine / Q000009:adverse effects / Q000627:therapeutic use; D004534:Egypt / Q000453:epidemiology; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000150:complications* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D003078:Colchicine