title: Validation of the Treatment Satisfaction Questionnaire for Medication in patients with cystic fibrosis.
abstract: BACKGROUND
  Our objective was to confirm the measurement properties of the Treatment Satisfaction Questionnaire with Medication (TQSM) in patients with cystic fibrosis (CF) receiving inhaled antibiotics.
  
  
  METHODS
  The TSQM was included in the EAGER study, a clinical trial comparing a nebulized and a dry powder device for inhaled tobramycin in a CF population with chronic Pseudomonas aeruginosa (Pa) lung infection, aged 6 years and above (N=553). Reliability and validity of the questionnaire were investigated using Cronbach's α and multitrait-multimethod approach.
  
  
  RESULTS
  The TSQM demonstrated very good reliability and construct validity: all Cronbach's α were above 0.86 and all items met the convergent and discriminant validity criteria. In multivariate regressions, higher patient satisfaction and lower perceived impact of side-effects were associated with better treatment compliance.
  
  
  CONCLUSIONS
  The TSQM showed very good measurement properties that strongly support its use to assess satisfaction of patients with CF taking inhaled antibiotics.
authors.affiliation: Mapi Consultancy, 27 rue de la Villette, 69003 Lyon, France. aregnault@mapigroup.com
authors.forename: Antoine
authors.initials: A
authors.lastname: Regnault
authors.forename: Maria-Magdalena
authors.initials: MM
authors.lastname: Balp
authors.forename: Károly
authors.initials: K
authors.lastname: Kulich
authors.forename: Muriel
authors.initials: M
authors.lastname: Viala-Danten
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence; D009330:Nebulizers and Vaporizers; D017060:Patient Satisfaction; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa; D011594:Psychometrics / Q000592:standards; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards*; D014031:Tobramycin / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin