title: Device closure of paravalvular defects following transcatheter aortic valve replacement with the Edwards Sapien valve.
abstract: Paravalvular aortic insufficiency (AI) is observed in the majority of patients undergoing transcatheter aortic valve replacement (TAVR). While paravalvular AI is most commonly modest following TAVR, moderate or severe AI was seen in 10.5% and 6.8% of the PARTNER inoperable and high-risk cohorts at 1 year and has been reportedly associated with dyspnea and diminished survival. We report two cases of transcatheter heart valve (THV) associated paravalvular defects closed using catheter delivered devices. Both patients derived hemodynamic and symptomatic improvement from device closure. Additional research is warranted to define the adverse consequences of THV associated AI, indications for treatment, and risks associated with device closure of these defects.
authors.affiliation: Intermountain Medical Center, Salt Lake City, Utah 84107, USA. brian.whisenant@imail.org
authors.forename: Brian
authors.initials: B
authors.lastname: Whisenant
authors.forename: Kent
authors.initials: K
authors.lastname: Jones
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Horton
authors.forename: Steve
authors.initials: S
authors.lastname: Horton
mesh_terms: D000369:Aged, 80 and over; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001027:Aortography; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D016896:Treatment Outcome