title: Ototoxicity of Burow solution on the guinea pig cochlea.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the ototoxicity of Burow solution.
  
  
  METHODS
  Compound action potentials (CAPs) of the eighth nerve were measured before and 30 minutes after the application of the Burow solution in the middle ear cavity.
  
  
  RESULTS
  Use of the original Burow solution (pH 3.5) for 30 minutes caused a significant reduction of click sounds. A 2-fold diluted Burow solution (pH 4.4) for 30 minutes caused no reduction in CAP threshold. Burow solution, pH adjusted to 4.5, caused no changes in CAP threshold at 30 minutes. At 24 hours, Burow solution (pH 3.5) caused complete abolition of CAP.
  
  
  CONCLUSIONS
  Burow solution is ototoxic in the guinea pig when applied in the middle ear cavity for 30 minutes or longer. In the clinical settings, it is advisable to avoid allowing the solution to contact the round window for extended times.
authors.affiliation: Department of Otolaryngology, School of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Sugamura
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yamano
authors.forename: Hitomi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Takase
authors.forename: Hisae
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Morizono
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000633:toxicity*; D000200:Action Potentials / Q000187:drug effects; D000287:Administration, Topical; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000085:Acetates; C013396:aluminum acetate