title: A special case of acute leukemia in childhood.
abstract: Hybrid leukemia is a clinical entity that includes: biphenotypic leukemia, characterized by the presence of markers of more than two lineages of a single tumor cell, bilineage leukemia, a combination of more than two lineage markers on two distinct blast cells, and biclonal leukemia, the concomitancy of more than two types of leukemic cells, derived from different clonal expansions. We present a case of a 7-year-old female diagnosed with bilineage leukemia. We propose a treatment for biphenotypic/bilineage leukemia in the cases with good prognostic factors. We suggest that hematopoietic stem cell transplantation is often not required for cure of these patients.
authors.affiliation: Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Pediatrics Department, Bucharest, Romania. dorinbleahu@gmail.com
authors.forename: Ion Dorin
authors.initials: ID
authors.lastname: Bleahu
authors.forename: Roxana
authors.initials: R
authors.lastname: Vladasel
authors.forename: Anca
authors.initials: A
authors.lastname: Gheorghe
mesh_terms: D000208:Acute Disease; D002648:Child; D005260:Female; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*