title: [Jugular venous and arterial concentrations of serum S100B protein in patients with severe head injury].
abstract: It is important for physicians in intensive care units to be able to predict the presence and severity of central nervous system injury in patients with severe head injury (SHI). The extent of S100B elevation has been found to be useful in predicting clinical outcome after brain injury. However, only two studies were realized with jugular venous blood samples. The purpose of our study is to compare the interest between jugular venous and arterial concentrations evaluation of serum S100B protein in patients with SHI. We recruited 17 patients with a SHI, admitted to the intensive care unit. Paired arterial and jugular venous samples were taken at kinetically after injury. S100B median was 0.16 μg/L in arterial and 0.25 μg/L in jugular. This arterio-jugular difference is significant. However, there was any significant arterio-jugular difference in the patients group showing an unfavourable outcome or for the earlier samples (earlier than 24h). We observed there was no significant decrease of S100B in jugular, unlike in arterial, 24h after the head injury in the patients group showing an unfavourable outcome. Determination of S100B concentration in jugular samples appears to be better than in arterial to predict clinical outcome after brain injury.
authors.affiliation: Service de biochimie médicale, Centre de biologie, CHU de Clermont-Ferrand, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Bouvier
authors.forename: Nathanaël
authors.initials: N
authors.lastname: Eisenmann
authors.forename: Thierry
authors.initials: T
authors.lastname: Gillart
authors.forename: Juliette
authors.initials: J
authors.lastname: Bonneau
authors.forename: Dominique
authors.initials: D
authors.lastname: Guelon
authors.forename: Pierre
authors.initials: P
authors.lastname: Schoeffler
authors.forename: Vincent
authors.initials: V
authors.lastname: Sapin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000737:chemistry*; D016022:Case-Control Studies; D006259:Craniocerebral Trauma / Q000097:blood* / Q000145:classification / Q000175:diagnosis; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007601:Jugular Veins / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis / Q000097:blood*; D009994:Osmolar Concentration; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000097:blood*; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human