title: [The polymorphism of DNA repair genes XRCC1, XRCC3 and the level of chromosomal aberrations in the Uranium workers].
abstract: Association between the polymorphism of DNA repair genes XRCC1 Arg399ln and XRCC3 Thr241Met and the frequency of chromosomal aberrations in the uranium workers was studied. The Gln/Gln genotype of gene XRCC1 was associated with a significant increase in the number of chromosomal aberrations as compared to the corresponding homozygous wild type Arg/Arg (p < 0.05). The frequency of chromosomal aberrations in heterozygous carriers of the XRCC3gene Thr/Met was lower than in the homozygous carriers of the wild type Thr/Thr (p < 0.001).
authors.forename: Z Zh
authors.initials: ZZh
authors.lastname: Vasil'eva
authors.forename: R I
authors.initials: RI
authors.lastname: Bersimbaev
authors.forename: B O
authors.initials: BO
authors.lastname: Bekmanov
authors.forename: I E
authors.initials: IE
authors.lastname: Vorobtsova
mesh_terms: D000483:Alleles; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007221:Industry; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D014501:Uranium / Q000009:adverse effects*; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; D014501:Uranium