title: Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis.
abstract: Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.
authors.affiliation: The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Bian
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Huanyu
authors.initials: H
authors.lastname: Lu
authors.forename: Guodong
authors.initials: G
authors.lastname: Yang
authors.forename: Zhang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Fu
authors.forename: Xiaozhao
authors.initials: X
authors.lastname: Lu
authors.forename: Mengying
authors.initials: M
authors.lastname: Wei
authors.forename: Jianyong
authors.initials: J
authors.lastname: Sun
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.forename: Guanglong
authors.initials: G
authors.lastname: Dong
authors.forename: Zifan
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000368:Aged; D049109:Cell Proliferation; D019175:DNA Methylation; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D016601:RNA-Binding Proteins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C490832:QKI protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins