title: Volumetric capnography curves as lung function test to confirm bronchoconstriction after carbachol challenge in sedated dogs.
abstract: This study investigated volumetric capnography (VC) in detecting airway responsiveness following airway challenge using carbachol in seven sedated dogs via face mask. Nebulised saline was administered, followed by increasing concentrations of nebulised carbachol until airflow limitation occurred (EP). Dead space (DS) variables and shape indices of the VC curve were calculated automatically after entering arterial carbon dioxide tension. Airway DS, airway DS to tidal volume (VT) ratio and the intercept of slope 2 of the VC curve decreased significantly at EP by 10%, 13% and 16%, respectively, minute ventilation, VT and alveolar DS increased significantly at EP by 49%, 22% and 200%, respectively. We conclude that VC and derived indices may be used to verify a reaction to airway challenge caused by carbachol in sedated dogs.
authors.affiliation: Clinic for Anesthesiology and Perioperative Intensive Care, Veterinary University Vienna, A-1210 Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Scheffzek
authors.forename: M
authors.initials: M
authors.lastname: Mosing
authors.forename: R
authors.initials: R
authors.lastname: Hirt
authors.forename: I
authors.initials: I
authors.lastname: Iff
authors.forename: Y
authors.initials: Y
authors.lastname: Moens
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D019296:Capnography / Q000662:veterinary*; D002217:Carbachol / Q000008:administration & dosage / Q000633:toxicity*; D018679:Cholinergic Agonists / Q000008:administration & dosage / Q000633:toxicity*; D016292:Procedural Sedation; D004285:Dogs; D008297:Male
chemical_list: D018679:Cholinergic Agonists; D002217:Carbachol