title: Predisposing factors for renal scarring in children with urinary tract infection.
abstract: This study was undertaken to determine the predisposing factors for renal scarring in children with urinary tract infection. In this prospective cohort study, 176 children with documented urinary tract infection were categorized into four groups: ≤1 year old, 1-2 years old, 2-7 years and 7-14 years old. Ultrasonography and Technetium-99 m-DMSA scan were used to detect the possible abnormalities. Infants under 12 months old presented as the most common group for renal scarring (27 cases, 52.9%), and vesicoureteral reflux (VUR) was diagnosed in 29 cases (56.8%). Fifteen (41.67%) children between the ages of one and two years had renal scar, and VUR was detected in half of the patients. In the third group, 36.3%, and in fourth group, 41.6% of the patients had renal scar. Also, 38.6% in group three and 50% in the final group had VUR. A co-incidental finding that was observed in this study was the high incidence of pseudohypoaldesteronism (PHA) in our patients: in 39.2% of the children in group one, 22.2% in group two and 4% in group three. In group four however, none of the patients had PHA. Risk of scar formation with urinary tract infection (UTI) was higher in the younger age group and in those with recurrent UTIs.
authors.affiliation: Nephronology and Urology Research Center, Baqiyatallah Medical Science, Tehran, Islamic Republc of Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Beiraghdar
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.forename: Behzad
authors.initials: B
authors.lastname: Einollahi
authors.forename: Yashar
authors.initials: Y
authors.lastname: Moharamzad
authors.forename: Eghlim
authors.initials: E
authors.lastname: Nemati
authors.forename: Susan
authors.initials: S
authors.lastname: Amirsalari
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007492:Iran / Q000453:epidemiology; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D011446:Prospective Studies; D011546:Pseudohypoaldosteronism / Q000453:epidemiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014463:Ultrasonography; D014552:Urinary Tract Infections / Q000453:epidemiology*; D014718:Vesico-Ureteral Reflux / Q000453:epidemiology
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid