title: T2 glottic carcinoma: analysis of recurrences in 36 cases undergoing primary transoral laser microsurgery resection.
abstract: OBJECTIVE
  Between 2002 and 2008, over 100 patients with glottic carcinoma have undergone transoral laser microsurgical (TLM) resection at the QEII Health Sciences Centre in Halifax, Nova Scotia. The objective of this study was to assess the oncologic outcomes for all cases staged as T2 in this cohort.
  
  
  METHODS
  A prospective database was developed to monitor outcomes. All 36 cases of primary T2 glottic carcinoma were selected from the database for analysis. Kaplan-Meier survival analyses evaluated the following end points at 36 months: overall survival, disease-specific survival, and local control and disease-free survival with one procedure.
  
  
  RESULTS
  The Kaplan-Meier estimates of 36-month outcomes were 89% (SE 6.0%) overall survival and disease-specific survival, 81% (SE 7.1%) local control with one procedure, and 70% (SE 8.0%) disease-free survival with one procedure.
  
  
  CONCLUSIONS
  The observed 36-month outcomes support the use of TLM as the primary treatment modality for T2 glottic cancers.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Dalhousie University, Halifax, NS.
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Rigby
authors.forename: Luke F
authors.initials: LF
authors.lastname: Reynolds
authors.forename: Robert D
authors.initials: RD
authors.lastname: Hart
authors.forename: Jonathan R B
authors.initials: JR
authors.lastname: Trites
authors.forename: Tim
authors.initials: T
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Mark Taylor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005931:Glottis; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology; D009367:Neoplasm Staging; D009674:Nova Scotia / Q000453:epidemiology; D011446:Prospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome