title: Pilot study of CD147 protein expression in epithelial ovarian cancer using monoclonal antibody 12C3.
abstract: OBJECTIVE
  CD147 is a membrane glycoprotein that is expressed in various cancer cells and is involved in tumor invasion and metastasis by inducing stromal fibroblastic cells to produce matrix metalloproteinases. This study was carried out to evaluate the correlation between CD147 expression and various clinicopathologic parameters, including histological grade and prognosis in a small sample set of human ovarian cancer patients.
  
  
  METHODS
  Paraffin-embedded surgical tissue samples from 25 patients with ovarian serous and endometrioid adenocarcinoma were stained with anti-CD147 antibody (monoclonal antibody 12C3: MoAb 12C3) for immunohistochemical analysis.
  
  
  RESULTS
  CD147 protein was expressed in 84.0% (21 of 25 cases) of cancerous lesions, but not in normal lesions. CD147 expression by ovarian cancer cells was inversely correlated with overall survival. There was no correlation between CD147 expression and histological grade.
  
  
  CONCLUSIONS
  These results suggest that measurement of CD147 expression may enhance the understanding of the pathophysiology of epithelial ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Kazu
authors.initials: K
authors.lastname: Ueda
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Yamada
authors.forename: Takako
authors.initials: T
authors.lastname: Kiyokawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iida
authors.forename: Chie
authors.initials: C
authors.lastname: Nagata
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hamada
authors.forename: Misato
authors.initials: M
authors.lastname: Saito
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Aoki
authors.forename: Nozomu
authors.initials: N
authors.lastname: Yanaihara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takakura
authors.forename: Aikou
authors.initials: A
authors.lastname: Okamoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ochiai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ohkawa
authors.forename: Tadao
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D010053:Ovary / Q000473:pathology; D010865:Pilot Projects
chemical_list: C520071:12C3 monoclonal antibody; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; C497886:BSG protein, human; D014408:Biomarkers, Tumor; D051926:Basigin