title: Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide".
abstract: A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of "borono-sclareolide", a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
authors.forename: Darryl D
authors.initials: DD
authors.lastname: Dixon
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Lockner
authors.forename: Qianghui
authors.initials: Q
authors.lastname: Zhou
authors.forename: Phil S
authors.initials: PS
authors.lastname: Baran
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D014966:Xanthenes / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001896:Boron Compounds; D004224:Diterpenes; D013729:Terpenes; D014966:Xanthenes; C109395:sclareolide; C121655:chromazonarol