title: Spontaneous clearance of chronic hepatitis C infection in a patient with a 20-year-old HIV-hepatitis C co-infection and chronic active hepatitis.
abstract: We report a case of spontaneous clearance of hepatitis C virus (HCV) in a patient co-infected for 20 years with HCV and HIV, and with an chronic active hepatitis C never treated with anti-HCV regimens. We review the literature of eight anecdotal reports describing the spontaneous resolution of chronic HCV infection among HIV-infected patients, and discuss the virological, immunological, pathogenetic and therapeutic implications of this observation.
authors.affiliation: Department of Internal Medicine, Aging, and Nephrologic Diseases, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola-Malpighi Hospital, Via Massarenti 11, Bologna I-40138, Italy. Roberto.manfredi@unibo.it
authors.forename: R
authors.initials: R
authors.lastname: Manfredi
authors.forename: N
authors.initials: N
authors.lastname: Dentale
authors.forename: L
authors.initials: L
authors.lastname: Calza
mesh_terms: D060085:Coinfection / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016174:Hepacivirus / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology* / Q000821:virology; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load