title: A proprietary topical preparation containing EGCG-stearate and glycerin with inhibitory effects on herpes simplex virus: case study.
abstract: The effects of a proprietary topical formulation containing EGCG-stearate in 100% glycerin USP were studied in two volunteer patients with recurrent herpes simplex (HSV) type 1. Application during early onset (prodromal stage) in a patient with herpes labialis prevented lesion progression. In a second patient with herpetic stomatitis, application of the formula during a later stage (inflammation stage) led to a remarkably shortened duration of symptoms. In contrast, a third patient provided 100% glycerin USP only as placebo failed to demonstrate any therapeutic or preventive effect against lesion occurrence or duration of lesion and healing time. These results suggest that this proprietary topical preparation could be used effectively to prevent and treat HSV-induced symptoms, and warrants further clinical investigation.
authors.affiliation: Department of General Dentistry, School of Stomatology Hospital, Zhejiang University, Hangzhou, China.
authors.forename: Man
authors.initials: M
authors.lastname: Zhao
authors.forename: Jinyan
authors.initials: J
authors.lastname: Jiang
authors.forename: Rongrong
authors.initials: R
authors.lastname: Zheng
authors.forename: Henna
authors.initials: H
authors.lastname: Pearl
authors.forename: Douglas
authors.initials: D
authors.lastname: Dickinson
authors.forename: Baiping
authors.initials: B
authors.lastname: Fu
authors.forename: Stephen
authors.initials: S
authors.lastname: Hsu
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002392:Catechin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005990:Glycerol / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D006560:Herpes Labialis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D018139:Simplexvirus / Q000187:drug effects / Q000502:physiology*; D013228:Stearates / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry
chemical_list: D013228:Stearates; D002392:Catechin; C057580:gallocatechol; D005990:Glycerol