title: Culcitiolides A-D, four new eremophilane-type sesquiterpene derivatives from Senecio culcitioides.
abstract: Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor kappaB (NF-kappaB). Culcitiolides C and D at 20 microM showed 97 and 100% inhibition of NF-kappaB activity, respectively.
authors.affiliation: Department of Biological Chemistry, Faculty of Science, Okayama University of Science, Okayama 700-0005, Japan. nozaki@dbc.ous.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kawai
authors.forename: Taichi
authors.initials: T
authors.lastname: Mitsui
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kido
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tani
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takaoka
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Uno
authors.forename: Susumu
authors.initials: S
authors.lastname: Ohira
authors.forename: Atsuto
authors.initials: A
authors.lastname: Kuboki
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
mesh_terms: D015394:Molecular Structure; D009281:Naphthalenes / Q000032:analysis / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry
chemical_list: D009281:Naphthalenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds