title: Society of toxicologic pathology position paper: review series: assessment of circulating hormones in nonclinical toxicity studies: general concepts and considerations.
abstract: This is an introductory paper to a series of papers intended to provide the basis for understanding the contribution of endocrine axis disruption or dysfunction to the pathogenesis of morphological findings and to aid in the interpretation of study outcomes. This is the first in this series of guidance papers prepared by the Working Group and outlines general concepts of study design and assay conduct and validation for hormone studies in general.
authors.affiliation: Reproductive Toxicology, Safety Assessment, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA. dinesh.j.stanislaus@gsk.com
authors.forename: Dinesh
authors.initials: D
authors.lastname: Stanislaus
authors.forename: Håkan
authors.initials: H
authors.lastname: Andersson
authors.forename: Robert
authors.initials: R
authors.lastname: Chapin
authors.forename: Dianne
authors.initials: D
authors.lastname: Creasy
authors.forename: Duncan
authors.initials: D
authors.lastname: Ferguson
authors.forename: Mary
authors.initials: M
authors.lastname: Gilbert
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Rosol
authors.forename: Rogely Waite
authors.initials: RW
authors.lastname: Boyce
authors.forename: Charles E
authors.initials: CE
authors.lastname: Wood
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000458:organization & administration / Q000592:standards; D005260:Female; D006728:Hormones / Q000032:analysis / Q000097:blood*; D006801:Humans; D008297:Male; D010336:Pathology / Q000458:organization & administration / Q000592:standards; D012107:Research Design; D018675:Toxicity Tests / Q000379:methods* / Q000592:standards
chemical_list: D006728:Hormones