title: A retrospective review on successful management of Penicillium marneffei infections in patients with advanced HIV in Hospital Sungai Buloh.
abstract: Penicillium marneffei is a dimorphic fungus which commonly causes a life threatening systemic fungal infection in an immunocompromised host. It has been recognized as an AIDS defining illness in Malaysia since the beginning of the HIV pandemic. The presence of various non specific clinical presentations, especially the characteristic umbilicated papular rashes with central necrosis which lead to significant ill health in immunocompromised patients should alarm clinicians to the possibility of Penicillium marneffei infection and prompt investigations accordingly. Simple investigations like blood culture and fungal staining of the skin scrapping can confirm the diagnosis in the majority of cases. Early treatment with appropriate systemic antifungal for a definite duration will significantly decrease the mortality rate from penicilliosis.
authors.affiliation: Infectious Disease Unit, Medical Dept, Hospital Sungai Buloh, Selangor, Malaysia. shaharuddin.norhayati@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Nor-Hayati
authors.forename: M
authors.initials: M
authors.lastname: Sahlawati
authors.forename: C
authors.initials: C
authors.lastname: Suresh-Kumar
authors.forename: K C Christopher
authors.initials: KC
authors.lastname: Lee
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D010407:Penicillium; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents