title: [Post-resuscitation syndrome. Role of inflammation after cardiac arrest].
abstract: Cardiac arrest with subsequent cardiopulmonary resuscitation causes an ischemic reperfusion syndrome of the whole body resulting in localized damage of particularly sensitive organs, such as the brain and heart, together with systemic sequelae. The main factor is a generalized activation of inflammatory reactions resulting in symptoms similar in many aspects to those of sepsis. Systemic inflammation strengthens organ damage due to disorders in the macrocirculation and microcirculation due to metabolic imbalance as well as the effects of direct leukocyte transmitted tissue destruction. The current article gives an overview on the role of inflammation following cardiac arrest and presents in detail the underlying mechanisms, the clinical symptoms and possible therapeutic approaches.
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937 Köln, Deutschland. andreas.schneider@uk-koeln.de
authors.forename: A
authors.initials: A
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Albertsmeier
authors.forename: B W
authors.initials: BW
authors.lastname: Böttiger
authors.forename: P
authors.initials: P
authors.lastname: Teschendorf
mesh_terms: D000303:Adrenal Cortex Diseases / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001831:Body Temperature / Q000502:physiology; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood; D006323:Heart Arrest / Q000150:complications* / Q000378:metabolism / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology; D006440:Hemofiltration; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007036:Hypothermia, Induced; D007239:Infections / Q000150:complications; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D017202:Myocardial Ischemia / Q000209:etiology; D015428:Myocardial Reperfusion Injury / Q000209:etiology; D018805:Sepsis / Q000503:physiopathology; D013577:Syndrome
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D006854:Hydrocortisone