title: Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone.
abstract: We asked whether plasma concentrations of endothelin-1 (ET-1) or adrenomedullin (ADM) are altered by different activity states of the renin-angiotensin-aldosterone system (RAAS). Levels of ET-1 and ADM were studied in patients with primary aldosteronism (n = 15), essential hypertension (n = 15), and adrenal insufficiency (n = 7). Effects of fludrocortisone, dexamethasone, or spironolactone treatment on ET-1 and ADM levels were also analyzed. Plasma ET-1 and ADM concentrations did not differ significantly between the patient groups. After fludrocortisone, dexamethasone, or spironolactone treatment, both ET-1 and ADM did not change significantly. The data support the hypothesis that the RAAS is not directly linked with the ET-1/ADM system.
authors.affiliation: Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Vogt
authors.forename: Elena
authors.initials: E
authors.lastname: Winkler
authors.forename: Derik
authors.initials: D
authors.lastname: Hermsen
authors.forename: Matthias
authors.initials: M
authors.lastname: Schott
authors.forename: Sven
authors.initials: S
authors.lastname: Schinner
authors.forename: Werner A
authors.initials: WA
authors.lastname: Scherbaum
authors.forename: Holger S
authors.initials: HS
authors.lastname: Willenberg
mesh_terms: D000309:Adrenal Insufficiency / Q000188:drug therapy; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003907:Dexamethasone / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use*; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000187:drug effects; D013148:Spironolactone / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D004232:Diuretics; D019332:Endothelin-1; D053607:Adrenomedullin; D013148:Spironolactone; D003907:Dexamethasone; D005438:Fludrocortisone