title: Hypoxia imaging using Positron Emission Tomography in non-small cell lung cancer: implications for radiotherapy.
abstract: Tumour hypoxia is an important contributor to radioresistance. Thus, increasing the radiation dose to hypoxic areas may result in improved locoregional tumour control. However, this strategy requires accurate detection of the hypoxic sub-volume using PET imaging. Secondly, hypoxia imaging may also provide prognostic information and may be of help to monitor treatment response. Therefore, a systematic review of the scientific literature was carried out on the use of Positron Emission Tomography (PET) to image Tumour hypoxia in non-small cell lung cancer (NSCLC). More specifically, the purpose of this review was (1) to summarize the different hypoxia tracers used, (2) to investigate whether Tumour hypoxia can be detected in NSCLC and finally (3) whether the presence of hypoxia can be used to predict outcome.
authors.affiliation: Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. v.r.bollineni@umcg.nl
authors.forename: Vikram Rao
authors.initials: VR
authors.lastname: Bollineni
authors.forename: Erwin M
authors.initials: EM
authors.lastname: Wiegman
authors.forename: Jan
authors.initials: J
authors.lastname: Pruim
authors.forename: Harry J M
authors.initials: HJ
authors.lastname: Groen
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D015687:Cell Hypoxia / Q000502:physiology; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy*; D049268:Positron-Emission Tomography / Q000379:methods