title: Putting a stop to L,D-transpeptidases.
abstract: In this issue of Structure, Lecoq et al. investigated the structural and dynamic basis for the unexpected inhibition of peptidoglycan-crosslinking l,d-transpeptidases by carbapenem antibiotics. In addition to defining a neutral thiol-imidazole catalytic triad, their studies revealed extensive induced motions upon formation of a long-live covalent drug-enzyme complex.
authors.affiliation: Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. somde@chem.ubc.ca
authors.forename: Soumya
authors.initials: S
authors.lastname: De
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: McIntosh