title: [The history and progress of antiviral research].
abstract: It has been considered for a long time that, unlike bacteria, viral replication cannot be halted by small-molecule compounds without affecting host-cell functions because of its innate association with the cell function. However, steady progress in antiviral chemotherapy has been made, starting from the discovery of the truly selective anti-herpes agent acyclovir. The discovery of human immunodeficiency virus type 1 as the causative agent of AIDS has dramatically accelerated the development of novel antiviral compounds. Currently, highly potent and selective inhibitors are also available in clinic for the treatment of influenza virus and hepatitis virus B and C infections.
authors.affiliation: Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University.
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
mesh_terms: D000998:Antiviral Agents / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents