title: Specific and non-specific enzymes for furanosyl-containing conjugates: biosynthesis, metabolism, and chemo-enzymatic synthesis.
abstract: There is no doubt now that the synthesis of compounds of varying complexity such as saccharides and derivatives thereof continuously grows with enzymatic methods. This review focuses on recent basic knowledge on enzymes specifically involved in the biosynthesis and degradation of furanosyl-containing polysaccharides and conjugates. Moreover, and when possible, biocatalyzed approaches, alternative to standard synthesis, will be detailed in order to strengthen the high potential of these biocatalysts to go further with the preparation of rare furanosides. Interesting results will be also proposed with chemo-enzymatic processes based on nonfuranosyl-specific enzymes.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France.
authors.forename: Ilona
authors.initials: I
authors.lastname: Chlubnova
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Rémy
authors.initials: R
authors.lastname: Dureau
authors.forename: Alizé
authors.initials: A
authors.lastname: Pennec
authors.forename: Mélanie
authors.initials: M
authors.lastname: Almendros
authors.forename: Richard
authors.initials: R
authors.lastname: Daniellou
authors.forename: Caroline
authors.initials: C
authors.lastname: Nugier-Chauvin
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D002240:Carbohydrate Sequence; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D005690:Galactose / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006001:Glycoconjugates / Q000096:biosynthesis* / Q000138:chemical synthesis; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000737:chemistry / Q000378:metabolism; D019751:Intramolecular Transferases / Q000737:chemistry / Q000378:metabolism; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D009005:Monosaccharides / Q000096:biosynthesis* / Q000138:chemical synthesis; D011134:Polysaccharides / Q000096:biosynthesis* / Q000138:chemical synthesis; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins; D006001:Glycoconjugates; D009005:Monosaccharides; D011134:Polysaccharides; C104136:uridine diphosphate galactofuranose; D014530:Uridine Diphosphate; D016695:Glycosyltransferases; D008049:Lipase; D006026:Glycoside Hydrolases; D019751:Intramolecular Transferases; D005690:Galactose