title: Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets.
abstract: The purpose of this study is to investigate the bioavailability and glycaemic metabolism of cinnamon oil (CIO) carried by liquid-loadable tablets (CIO-LLTs), the carrier of a CIO self-emulsifying formulation (CIO-LS). The results of tests performed to evaluate the physical properties of the CIO-LLT complied with Chinese Pharmacopeia (2010). The release profile suggested that the CIO-LLT preserved the enhancement of in vitro dissolution of cio. After orally administration, the plasma concentration-time profile and pharmacokinetic parameters suggested that a significant increase (P < 0.0001) in the C(max), AUC and F were observed in the CIO-LLT. The blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic rats (P < 0.05, P < 0.01, resp.), while the level of insulin secretion was markedly elevated in alloxan-induced hyperglycemic rats (P < 0.05). The alloxan-damaged pancreatic β-cells of the rats were partly recovered gradually after the rats were administered with CIO-LLT 45 days later. CIO-LLT could improve the bioavailability and glycaemic metabolism of CIO.
authors.affiliation: School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
authors.forename: Chunchao
authors.initials: C
authors.lastname: Han
authors.forename: Bo
authors.initials: B
authors.lastname: Cui
mesh_terms: D000284:Administration, Oral; D000496:Alloxan / Q000009:adverse effects; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D001786:Blood Glucose / Q000378:metabolism; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects; D008297:Male; D010316:Particle Size; D010938:Plant Oils / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011786:Quality Control; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets / Q000008:administration & dosage / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D000496:Alloxan; D001786:Blood Glucose; D004337:Drug Carriers; D006442:Glycated Hemoglobin; D007328:Insulin; D010938:Plant Oils; D013607:Tablets