title: Use of serum homocysteine to predict cardiovascular disease in Korean men with or without metabolic syndrome.
abstract: The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects. The subjects were divided into four subgroups: 34 CVD/MetS, 104 CVD, 77 MetS, and 213 normal subgroups. The mean Hcy was significantly higher, whereas HDL and intake of vitamin B(1) and B(2) were lower in the CVD group (P < 0.05) than non-CVD group. When compared to the control group, subjects with CVD/MetS, CVD and MetS exhibited high Hcy levels, with the highest observed in the CVD/MetS subgroup (P < 0.001). Multivariate stepwise linear regression between CVD and markers of CVD showed Hcy significantly correlated with CVD (P < 0.05). To predict CVD based on Hcy, Hcy threshold of 11.72 µM in non-MetS subjects had an area under the curve (AUC) of 0.664 (95% CI 0.598-0.731). In MetS subjects, the AUC was 0.618 and Hcy threshold was 13.32 µM (95% CI 0.509-0.726). The results of our study show that the presence of MetS needs to be considered when using Hcy levels for predicting CVD.
authors.affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd, Seoul, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kang
authors.forename: Ill Keun
authors.initials: IK
authors.lastname: Park
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Sung
authors.forename: Youn Koun
authors.initials: YK
authors.lastname: Chang
authors.forename: Yoo Kyoung
authors.initials: YK
authors.lastname: Park
authors.forename: Tae In
authors.initials: TI
authors.lastname: Choi
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D019587:Dietary Supplements; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D011237:Predictive Value of Tests; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL; D006710:Homocysteine