title: [A complex of heparin with the peptide Arg-Pro-Gly-Pro and its anticoagulative, fibrinolytic, and hyperglycemia effects].
abstract: Heparin was bound to the arginine-containing peptide Arg-Pro-Gly-Pro with the molar ratio of heparin to the peptide 1:1. The complex compound showed antiplatelet, anticoagulative, and fibrin-depolymerization activities. In an in vivo study, in type 2 diabetes progression, a 5-fold intranasal administration of the compound restored both impaired insular and anticlotting functions in rats. Furthermore, blood fibrinolytic and anticoagulative activities increased.
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Obergan
authors.forename: T A
authors.initials: TA
authors.lastname: Shubina
authors.forename: M E
authors.initials: ME
authors.lastname: Grigor'eva
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D015912:Thrombolytic Therapy
chemical_list: D000925:Anticoagulants; C572888:Arg-Pro-Gly-Pro; D009842:Oligopeptides; D010455:Peptides; D006493:Heparin