title: Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation.
abstract: Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or tumor) and ensure normal adult size. Such plasticity entails tissue and organ communication to preserve their proportions and symmetry. Here, we show that imaginal discs autonomously activate DILP8, a Drosophila insulin-like peptide, to communicate abnormal growth and postpone maturation. DILP8 delays metamorphosis by inhibiting ecdysone biosynthesis, slowing growth in the imaginal discs, and generating normal-sized animals. Loss of dilp8 yields asymmetric individuals with an unusually large variation in size and a more varied time of maturation. Thus, DILP8 is a fundamental element of the hitherto ill-defined machinery governing the plasticity that ensures developmental stability and robustness.
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández de Elche, Sant Joan d'Alacant, 03550 Alicante, Spain.
authors.forename: Andres
authors.initials: A
authors.lastname: Garelli
authors.forename: Alisson M
authors.initials: AM
authors.lastname: Gontijo
authors.forename: Veronica
authors.initials: V
authors.lastname: Miguela
authors.forename: Esther
authors.initials: E
authors.lastname: Caparros
authors.forename: Maria
authors.initials: M
authors.lastname: Dominguez
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D004440:Ecdysone / Q000096:biosynthesis; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D060227:Imaginal Discs / Q000254:growth & development / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D007814:Larva / Q000254:growth & development; D008675:Metamorphosis, Biological / Q000235:genetics; D008969:Molecular Sequence Data; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010448:Peptide Initiation Factors / Q000235:genetics / Q000378:metabolism; D011679:Pupa / Q000254:growth & development; D012038:Regeneration
chemical_list: D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D010448:Peptide Initiation Factors; C410006:Thor protein, Drosophila; C572149:insulin-like peptide 8, Drosophila; D004440:Ecdysone; D005020:Ethyl Methanesulfonate