title: [Folic acid supplementation and colorrectal adenoma recurrence: systematic review].
abstract: BACKGROUND
  Observational studies show that folate levels may be associated with the development of adenomas and colorectal cancer, suggesting that folic acid supplementation may have a preventive effect.
  
  
  OBJECTIVE
  Systematic review of scientific evidence from randomized placebo-controlled clinical studies to identify the effects of folic acid supplementation on the recurrence of colorectal adenomas.
  
  
  METHODS
  Medline via Pubmed systematic review of randomized clinical trials, double-blind and placebo-controlled and references, specifically to evaluate the effect of acid supplementation on the recurrence of colorectal adenomas.
  
  
  RESULTS
  Seven randomized clinical trials that met the inclusion criteria were selected and evaluated for analysis based on pre established criteria.
  
  
  CONCLUSIONS
  The selected studies do not support that folic acid supplementation is beneficial in recurrence of colorectal adenomas. We observed in some studies differences in risk by type of folate suggesting to review the criteria and levels of supplementation in some population subgroups with higher risks.
authors.affiliation: Grup de Recerca en Nutrició Comunitária i Estrès Oxidatiu, Departament de Biología Fonamental i Ciéncies de Salut, Universitat de Illes Balears, Palma de Mallorca, España. dracastillo@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Castillo-Lancellotti
authors.forename: J A
authors.initials: JA
authors.lastname: Tur Marí
authors.forename: R
authors.initials: R
authors.lastname: Uauy Dagach
mesh_terms: D000236:Adenoma / Q000517:prevention & control*; D000818:Animals; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D019587:Dietary Supplements; D005492:Folic Acid / Q000627:therapeutic use*; D006397:Hematinics / Q000627:therapeutic use*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D016032:Randomized Controlled Trials as Topic
chemical_list: D006397:Hematinics; D005492:Folic Acid