title: Targeting cancer gene therapy with magnetic nanoparticles.
abstract: Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using external magnetic fields, and also allows simultaneous imaging to monitor the delivery in vivo. Compared to conventional gene delivery strategies, this technique has been shown to significantly increase gene delivery to human xenograft tumors models, as well as various internal organs (e.g. liver, kidney) and the central nervous system. Magnetic nanoparticle technology, therefore, has the potential to turn the challenge of gene therapy in vivo into a new frontier for cancer treatment.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. cli1@bidmc.harvard.edu
authors.forename: Charles
authors.initials: C
authors.lastname: Li
authors.forename: Linda
authors.initials: L
authors.lastname: Li
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Keates
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy; D006801:Humans; D058185:Magnetite Nanoparticles; D051379:Mice; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D023041:Xenograft Model Antitumor Assays
chemical_list: D058185:Magnetite Nanoparticles