title: Safety of transcatheter patent ductus arteriosus closure in small weight infants.
abstract: BACKGROUND
  Patent ductus arteriosus (PDA) is a frequent congenital heart disease. Its transcatheter closure has become the treatment of choice in children and adults. However, the device closure of PDA in children with low weight is still challenging with high rate of complications. The aim of this study was to report further experience with trancatheter closure of PDA using the Amplatzer Duct Occluder(ADO) for children weighing less or equal to 8 kg.
  
  
  METHODS
  Twenty-two patients (5 male, 17 female) underwent transcatheter closure of a PDA using ADO at a median age of 10 months (range 4 to 26) and a median weight of 7 kg (range 4.3 to 8). Follow-up evaluations were performed with Doppler echocardiography at 24h, and at 6 and 12 months.
  
  
  RESULTS
  The device was implanted successfully in all patients. The median fluoroscopy time was 17.25 min (range 10 to 29). Within 24h, color Doppler revealed complete closure in 15 patients (68%), the other patients had a small residual shunt. No deaths were associated with the procedure. Two patients had a slight aortic protrusion of the device without coarctation and in one patient the device encroached partially on the left pulmonary artery without significant acceleration on Doppler echocardiography. All patients were discharged home the next day. All patients completed the 6-month follow-up with complete closure in 18 patients (81%). At the last evaluation in all patients at any time, there has been documentation of complete PDA closure in 20 (91%) of 22 patients.
  
  
  CONCLUSIONS
  In patients weighing less or equal to 8 kg, percutaneous closure of PDA using an ADO is a safe and effective procedure.
authors.affiliation: Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco. sdrighil@gmail.com
authors.forename: Abdenasser
authors.initials: A
authors.lastname: Drighil
authors.forename: Mansour
authors.initials: M
authors.lastname: Al Jufan
authors.forename: Khalid
authors.initials: K
authors.lastname: Al Omrane
authors.forename: Jameel
authors.initials: J
authors.lastname: Al Atta
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al Omrani
authors.forename: Fadel
authors.initials: F
authors.lastname: Al Fadley
mesh_terms: D001835:Body Weight; D006328:Cardiac Catheterization; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000628:therapy*; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D055989:Septal Occluder Device / Q000009:adverse effects*; D016896:Treatment Outcome