title: Prediction of genetic polymorphisms of DNA repair genes XRCC1 and XRCC3 in the survival of colorectal cancer receiving chemotherapy in the Chinese population.
abstract: OBJECTIVE
  We aimed to detect the distribution of DNA repair genes XRCC1 and XRCC3 genotypes in the survival of colorectal cancer patients receiving chemotherapy in the Chinese population.
  
  
  METHODS
  The prospective study was conducted with 432 cases treated with 5-FU and oxaliplatin as first-line chemotherapy. All the patients were followed-up from May 2006 to May 2011 and 168 patients died during follow-up. XRCC1 and XRCC3 genotype polymorphisms were based upon the PCR-CTPP method.
  
  
  RESULTS
  It was shown that the XRCC1 Arg399Gln and XRCC3 Thr241Met gene polymorphisms were associated with increased death risk of colorectal cancer. Individuals carrying XRCC1 Gln/Gln, Thr/Met and Met/Met genotypes positively associated with 2.78-, 2.86- and 3.0-fold death risk of colorectal cancer. Moreover, the combination of XRCC1 399Gln allele and XRCC3 241Met allele showed a significantly strong association with death risk of colorectal cancer (OR=3.46, 95%CI=1.65- 5.48).
  
  
  CONCLUSIONS
  This study is first to report that the XRCC1 and XRCC3 gene polymorphisms are useful as a surrogate marker of clinical outcome in colorectal cancer with 5-FU/oxaliplatin combination chemotherapy in the Chinese population.
authors.affiliation: Department of Pathology, Central South University, HuNan, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Haihui
authors.initials: H
authors.lastname: Chen
authors.forename: Limin
authors.initials: L
authors.lastname: Chen
authors.forename: Chunhong
authors.initials: C
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009944:Organoplatinum Compounds; D000076105:X-ray Repair Cross Complementing Protein 1; C110901:X-ray repair cross complementing protein 3; C000619371:XRCC1 protein, human; D000077150:Oxaliplatin; D005472:Fluorouracil