title: Transient phenomena in gene expression after induction of transcription.
abstract: When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.
authors.affiliation: Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
authors.forename: Carlus
authors.initials: C
authors.lastname: Deneke
authors.forename: Sophia
authors.initials: S
authors.lastname: Rudorf
authors.forename: Angelo
authors.initials: A
authors.lastname: Valleriani
mesh_terms: D003198:Computer Simulation; D015870:Gene Expression; D008954:Models, Biological; D020871:RNA Stability / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D012333:RNA, Messenger