title: [Retrospective comparative study between sevoflurane and propofol in maintaining anaesthesia during liver transplant: Effects on kidney and liver function].
abstract: OBJECTIVE
  To compare the post-operative effects of sevoflurane versus propofol on liver and kidney function while maintaining anaesthesia in the orthotopic liver transplant (OLT), as well as to analyse the short-term survival as regards these functions.
  
  
  METHODS
  A retrospective analysis was conducted on patients subjected to an OLT between January 2002 and December 2009. Patients on pre-transplant haemodialysis, re-transplants, and hepatorenal transplants were excluded. The incidence of acute renal failure, initial dysfunction of the graft, reperfusion syndrome, rejection, and the transaminase peak depending value depending on the hypnotic used, were recorded.
  
  
  RESULTS
  About one-third (31.2%) of the patients developed acute renal failure and 11.9% an initial dysfunction, with no differences between the groups. There was a tendency for a lower incidence of initial dysfunction of the graft in the sevoflurane group (8.6% compared to 12.8%), a lower transaminase peak (greater than 2000 U/L, 12.1% versus 15.9%), and a lower incidence of reperfusion syndrome (10.3% compared to 21.6%).
  
  
  CONCLUSIONS
  Despite the fact that the renal metabolism sevoflurane is elevated, we did not find any higher incidence of acute renal failure. Sevoflurane in the liver transplant anaesthesia is as least equally as safe propofol as regards renal function and liver function. New prospective studies are needed to clarify the possible effects of the hypnotic in liver transplant.
authors.affiliation: Servicio de Anestestesiología y Reanimación, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, España.
authors.forename: B
authors.initials: B
authors.lastname: Alonso Menárguez
authors.forename: L
authors.initials: L
authors.lastname: Gajate Martín
authors.forename: J
authors.initials: J
authors.lastname: García Suárez
authors.forename: A
authors.initials: A
authors.lastname: Martín Martín
authors.forename: R
authors.initials: R
authors.lastname: Moreno Ballesteros
authors.forename: P
authors.initials: P
authors.lastname: Arribas Pérez
authors.forename: J
authors.initials: J
authors.lastname: García Fernández
mesh_terms: D058186:Acute Kidney Injury; D000758:Anesthesia; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D007668:Kidney / Q000187:drug effects* / Q000502:physiology*; D008099:Liver / Q000187:drug effects* / Q000502:physiology*; D016031:Liver Transplantation; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D012189:Retrospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol