title: The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB.
abstract: The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.
authors.affiliation: Department of Neuroscience, Columbia University, New York, NY 10032, USA. erk5@columbia.edu
authors.forename: Eric R
authors.initials: ER
authors.lastname: Kandel
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D008568:Memory; D016601:RNA-Binding Proteins / Q000378:metabolism*; D020218:Response Elements / Q000235:genetics*
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D016601:RNA-Binding Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases