title: 8q24 and 17q prostate cancer susceptibility loci in a multiethnic Asian cohort.
abstract: OBJECTIVE
  Recently, several genome-wide association studies have demonstrated a cumulative association of 5 polymorphic variants in chromosomes 8q24 and 17q with prostate cancer (CaP) risk in Caucasians, particularly those harboring aggressive clinicopathologic characteristics. The purpose of this study was to evaluate the influence of these variants on CaP susceptibility in Singaporean Asian men.
  
  
  METHODS
  We performed a case-control study in 289 Chinese CaP patients and 412 healthy subjects (144 Chinese, 134 Malays, and 134 Indians), and examined the association of the 5 single nucleotide polymorphisms (SNPs) with CaP.
  
  
  RESULTS
  In the healthy subjects, rs16901979 A-allele frequency was highest amongst Chinese (0.32) compared with Malays (0.13; P < 0.0001) or Indians (0.09; P < 0.0001); rs6983267 G-allele was highest in Indians (0.51) compared with Chinese (0.42; P = 0.041) or Malays (0.43; P = 0.077); whereas rs1859962 G-allele frequency was highest amongst Indians (0.56) compared with Chinese (0.40; P = 0.0002) or Malays (0.38; P < 0.0001). Individuals with the rs4430796 TT genotype were at increased CaP risk in the Chinese via a recessive model (odds ratios (OR) = 1.56, 95% CI = 1.04-2.33). Significant associations were observed for rs4430796 TT with Gleason scores of ≥ 7 (OR = 1.76, 95% CI = 1.14-2.73) and prostate-specific antigen (PSA) levels of ≥ 10 ng/ml at diagnosis (OR = 1.63, 95% CI = 1.01-2.63), as well as for rs6983267 GG with stage 3-4 CaPs (OR = 1.91, 95% CI = 1.01-3.61). A cumulative gene interaction influence on disease risk, which approximately doubled for individuals with at least 2 susceptibility genotypes, was also identified (OR = 2.18, 95% CI = 1.10-4.32).
  
  
  CONCLUSIONS
  This exploratory analysis suggests that the 5 genetic variants previously described may contribute to prostate cancer risk in Singaporean men.
authors.affiliation: Department of Medical Oncology, National Cancer Centre, Singapore.
authors.forename: Jason Yongsheng
authors.initials: JY
authors.lastname: Chan
authors.forename: Huihua
authors.initials: H
authors.lastname: Li
authors.forename: Onkar
authors.initials: O
authors.lastname: Singh
authors.forename: Anupama
authors.initials: A
authors.lastname: Mahajan
authors.forename: Saminathan
authors.initials: S
authors.lastname: Ramasamy
authors.forename: Koilan
authors.initials: K
authors.lastname: Subramaniyan
authors.forename: Ravindran
authors.initials: R
authors.lastname: Kanesvaran
authors.forename: Hong Gee
authors.initials: HG
authors.lastname: Sim
authors.forename: Tsung Wen
authors.initials: TW
authors.lastname: Chong
authors.forename: Yik-Ying
authors.initials: YY
authors.lastname: Teo
authors.forename: Sin Eng
authors.initials: SE
authors.lastname: Chia
authors.forename: Min-Han
authors.initials: MH
authors.lastname: Tan
authors.forename: Balram
authors.initials: B
authors.lastname: Chowbay
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005787:Gene Frequency; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007194:India / Q000208:ethnology; D016015:Logistic Models; D008296:Malaysia / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics*; D012846:Singapore
chemical_list: D017430:Prostate-Specific Antigen