title: The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery.
abstract: BACKGROUND
  We made a comparative study on the antiemetic effect of midazolam and ondansetron added to intravenous patient-controlled analgesia (PCA) using fentanyl with gynecologic patients undergoing pelviscopic surgery.
  
  
  METHODS
  The PCA using 20 µg/kg of fentanyl was started in all groups postoperatively. A dose of 16 mg of ondansetron was added to the PCA of group O (n = 30). A dose of 5 mg of midazolam was added to the PCA of group M (n = 30). While 16 mg of ondansetron and 5 mg of midazolam were added to the PCA of group MO (n = 30). Total volume of the PCA was 60 ml, and the PCA system was programmed to deliver 0.5 ml/h of continuous doses and a 0.5 ml bolus on demand, with a 15 minutes lockout interval. The incidence of postoperative nausea and vomiting (PONV), sedation score, visual analog scale (VAS) for pain, and rescue drug dose for PONV were investigated at the postanesthesia care unit (PACU), 6 hours, and 24 hours after recovery.
  
  
  RESULTS
  The incidence of PONV in group MO was significantly lower than in group O at PACU, 24 hours after recovery (P < 0.05). The sedation score and VAS pain score showed no differences among all groups.
  
  
  CONCLUSIONS
  Midazolam added to PCA using fentanyl proved more effective than ondansetron in preventing PONV without adverse effects.
authors.affiliation: Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
authors.forename: Dae Seong
authors.initials: DS
authors.lastname: Kim
authors.forename: Gill Hoi
authors.initials: GH
authors.lastname: Koo
authors.forename: Hyun
authors.initials: H
authors.lastname: Kang
authors.forename: Chong Wha
authors.initials: CW
authors.lastname: Baek
authors.forename: Yong Hun
authors.initials: YH
authors.lastname: Jung
authors.forename: Young Cheol
authors.initials: YC
authors.lastname: Woo
authors.forename: Jin Yun
authors.initials: JY
authors.lastname: Kim
authors.forename: Sun Gyoo
authors.initials: SG
authors.lastname: Park