title: Antiprotozoal sesquiterpene pyridine alkaloids from Maytenus ilicifolia.
abstract: As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC(50) values of 1.4 and 41.9 μM, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC(50) of 1.8 mM).
authors.affiliation: Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista (UNESP), Araraquara, SP 14800-900, Brazil. vaniaapf@gmail.com
authors.forename: Vânia A F F M
authors.initials: VA
authors.lastname: Santos
authors.forename: Luis O
authors.initials: LO
authors.lastname: Regasini
authors.forename: Cláudio R
authors.initials: CR
authors.lastname: Nogueira
authors.forename: Gabriela D
authors.initials: GD
authors.lastname: Passerini
authors.forename: Isabel
authors.initials: I
authors.lastname: Martinez
authors.forename: Vanderlan S
authors.initials: VS
authors.lastname: Bolzani
authors.forename: Márcia A S
authors.initials: MA
authors.lastname: Graminha
authors.forename: Regina M B
authors.initials: RM
authors.lastname: Cicarelli
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D007891:Leishmania / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects; D029755:Maytenus / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents; D011725:Pyridines; D012717:Sesquiterpenes; C574281:ilicifoliunine A; C574282:ilicifoliunine B