title: The nervous system's potential role in multiple sclerosis associated bone loss.
abstract: Osteoporosis is a degenerative bone disease that causes significant morbidity and mortality in multiple sclerosis (MS) patients; the pathogenesis of this disease being poorly understood in the context of MS. Osteoporosis is seen more frequently in MS patients than in healthy controls matched for age and sex. Extensively studied factors, including impaired ambulation and the use of steroids, do not appear to completely account for the phenomenon. This review summarizes common risk factors, physiologic and genetic, that may contribute to the etiology and progression of osteoporosis in MS patients as well as providing insight into nervous system control of bone metabolism and homeostasis.
authors.affiliation: Dept. of Neurology, SUNY Buffalo, 100 High Street, Buffalo, NY 14203, USA.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Josyula
authors.forename: Bijal K
authors.initials: BK
authors.lastname: Mehta
authors.forename: Yuval
authors.initials: Y
authors.lastname: Karmon
authors.forename: Barbara
authors.initials: B
authors.lastname: Teter
authors.forename: Sonia
authors.initials: S
authors.lastname: Batista
authors.forename: Joseph
authors.initials: J
authors.lastname: Ostroff
authors.forename: Bianca
authors.initials: B
authors.lastname: Weinstock-Guttman
mesh_terms: D015519:Bone Density / Q000502:physiology; D002490:Central Nervous System / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010024:Osteoporosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors