title: Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid.
abstract: BACKGROUND
  The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken.
  
  
  METHODS
  Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption.
  
  
  RESULTS
  There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption.
  
  
  CONCLUSIONS
  Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats.
authors.affiliation: Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Biomedical Sciences, Nagasaki University, Japan.
authors.forename: Irin
authors.initials: I
authors.lastname: Sirisoontorn
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hotokezaka
authors.forename: Megumi
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Carmen
authors.initials: C
authors.lastname: Gonzales
authors.forename: Suwannee
authors.initials: S
authors.lastname: Luppanapornlarp
authors.forename: M Ali
authors.initials: MA
authors.lastname: Darendeliler
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D017698:Postmenopause; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000209:etiology / Q000517:prevention & control*; D014087:Tooth Movement Techniques / Q000009:adverse effects*; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid