title: Italian multicenter experience with flow-diverter devices for intracranial unruptured aneurysm treatment with periprocedural complications--a retrospective data analysis.
abstract: BACKGROUND
  We report the experiences of 25 Italian centers, analyzing intra- and periprocedural complications of endovascular treatment of intracranial aneurysms using Silk (Balt Extrusion, Montmorency, France) and pipeline embolization devices (EV3 Inc, Irvine California).
  
  
  METHODS
  Two hundred seventy-three patients with 295 cerebral aneurysms, enrolled in 25 centers in Italy and treated with the new flow-diverter devices, were evaluated; 142 patients were treated with Silk and 130 with pipeline (in one case, both devices were used). In 14 (5.2 %) cases devices were used with coils. Aneurysm size was >15 mm in 46.9 %, 5-15 mm in 42.2 %, and <5 mm in 10.8 %. Aneurysm locations were supraclinoid internal carotid artery (ICA) in 163 cases (55.2 %), cavernous ICA in 76 (25.7 %), middle cerebral artery in 11 (3.7 %), PCoA in 6 (2 %), and ACoA in 2 (0.7 %); the vertebrobasilar system accounted for 32 cases (10.8 %) and PCA in 5 (1.7 %).
  
  
  RESULTS
  Technical adverse events occurred with 59 patients (21.6 %); 5 patients died after ischemic events, 10 to hemorrhagic complications, and 1 from external ventricular drain positioning. At 1 month, morbidity and mortality rates were 3.7 % and 5.9 %, respectively
  
  
  CONCLUSIONS
  Our retrospective study confirms that morbidity and mortality rates in treatment with FDD of unruptured wide-neck or untreatable cerebral aneurysms do not differ from those reported in the largest series.
authors.affiliation: Interventional Neuroradiology Unit, "Federico II" University, Via S.Pansini 5, 80131 Naples, Italy. frabriga@unina.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Briganti
authors.forename: Manuela
authors.initials: M
authors.lastname: Napoli
authors.forename: Fabio
authors.initials: F
authors.lastname: Tortora
authors.forename: Domenico
authors.initials: D
authors.lastname: Solari
authors.forename: Mauro
authors.initials: M
authors.lastname: Bergui
authors.forename: Edoardo
authors.initials: E
authors.lastname: Boccardi
authors.forename: Enrico
authors.initials: E
authors.lastname: Cagliari
authors.forename: Lucio
authors.initials: L
authors.lastname: Castellan
authors.forename: Francesco
authors.initials: F
authors.lastname: Causin
authors.forename: Elisa
authors.initials: E
authors.lastname: Ciceri
authors.forename: Luigi
authors.initials: L
authors.lastname: Cirillo
authors.forename: Roberto
authors.initials: R
authors.lastname: De Blasi
authors.forename: Luigi
authors.initials: L
authors.lastname: Delehaye
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Paola
authors.forename: Andrea
authors.initials: A
authors.lastname: Fontana
authors.forename: Roberto
authors.initials: R
authors.lastname: Gasparotti
authors.forename: Giulio
authors.initials: G
authors.lastname: Guidetti
authors.forename: Ignazio
authors.initials: I
authors.lastname: Divenuto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iannucci
authors.forename: Maurizio
authors.initials: M
authors.lastname: Isalberti
authors.forename: Marco
authors.initials: M
authors.lastname: Leonardi
authors.forename: Fernando
authors.initials: F
authors.lastname: Lupo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Mangiafico
authors.forename: Andrea
authors.initials: A
authors.lastname: Manto
authors.forename: Roberto
authors.initials: R
authors.lastname: Menozzi
authors.forename: Mario
authors.initials: M
authors.lastname: Muto
authors.forename: Nunzio Paolo
authors.initials: NP
authors.lastname: Nuzzi
authors.forename: Rosario
authors.initials: R
authors.lastname: Papa
authors.forename: Benedetto
authors.initials: B
authors.lastname: Petralia
authors.forename: Mariangela
authors.initials: M
authors.lastname: Piano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Resta
authors.forename: Riccardo
authors.initials: R
authors.lastname: Padolecchia
authors.forename: Andrea
authors.initials: A
authors.lastname: Saletti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sirabella
authors.forename: Luca Piero Valvassori
authors.initials: LP
authors.lastname: Bolgè
mesh_terms: D000368:Aged; D017542:Aneurysm, Ruptured / Q000401:mortality / Q000601:surgery; D001807:Blood Vessel Prosthesis / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000401:mortality* / Q000601:surgery*; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents / Q000706:statistics & numerical data*; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome