title: Pulmonary carcinoid tumors and asbestos exposure.
abstract: OBJECTIVE
  The hypothesis that asbestos exposure may have more specific associations with particular histological types of lung cancer remains controversial. The aim of this study was to analyze the relationships between asbestos exposure and pulmonary carcinoid tumors.
  
  
  METHODS
  A retrospective case-control study was conducted in 28 cases undergoing surgery for pulmonary carcinoid tumors and aged >40 years and in 56 controls with lung cancer of a different histological type, matched for gender and age, from 1994 to 1999, recruited in two hospitals in the region of Paris. Asbestos exposure was assessed via expertise of a standardized occupational questionnaire and mineralogical analysis of lung tissue, with quantification of asbestos bodies (AB).
  
  
  RESULTS
  Definite asbestos exposure was identified in 25% of cases and 14% of controls (ns). Cumulative asbestos exposure was significantly higher in cases than in controls (P < 0.05), and results of the quantification of AB tended to be higher in cases than in controls (24 and 9% had >1000 AB per gram dry lung tissue, respectively, P = 0.09). Mean cumulative smoking was lower in cases than in controls (P < 0.05).
  
  
  CONCLUSIONS
  This study argues in favor of a relationship between asbestos exposure and certain pulmonary carcinoid tumors.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U955, Equipe 4, Créteil 94000, France. clin-b@chu-caen.fr
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Clin
authors.forename: Pascal
authors.initials: P
authors.lastname: Andujar
authors.forename: Issam
authors.initials: I
authors.lastname: Abd Al Samad
authors.forename: Chantal
authors.initials: C
authors.lastname: Azpitarte
authors.forename: Françoise
authors.initials: F
authors.lastname: Le Pimpec-Barthes
authors.forename: Marie-Annick
authors.initials: MA
authors.lastname: Billon-Galland
authors.forename: Claire
authors.initials: C
authors.lastname: Danel
authors.forename: Françoise
authors.initials: F
authors.lastname: Galateau-Salle
authors.forename: Bruno
authors.initials: B
authors.lastname: Housset
authors.forename: Karinne
authors.initials: K
authors.lastname: Legrand-Cattan
authors.forename: Mireille
authors.initials: M
authors.lastname: Matrat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Monnet
authors.forename: Marc
authors.initials: M
authors.lastname: Riquet
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pairon
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000633:toxicity*; D002276:Carcinoid Tumor / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010297:Paris; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D001194:Asbestos