title: Angiotensin II type 1 receptor (AT-1R) expression correlates with VEGF-A and VEGF-D expression in invasive ductal breast cancer.
abstract: Recent studies point to the involvement of angiotensin II (Ang II) receptor type 1 (AT-1R) on processes of metastasing, stimulation of invasiveness and angiogenesis in tumours. In this study, the correlation between intensity of AT-1R expression and expression of lymph- and angiogenesis markers in invasive ductal breast cancers (IDC) was examined. Immunohistochemical studies (IHC) were performed on archival material of 102 IDC cases. Only 28 (27.5%) cases manifested low AT-1R expression while 74 (72.5%) cases demonstrated a moderate or pronounced AT-1R expression. Expression intensity of AT-1R was found to correlate with expressions of VEGF-A (r = 0.26; p = 0.008) and VEGF-D (r = 0.24; p = 0.015). Out of the examined markers of angiogenesis and lymphangiogenesis only the pronounced expression of VEGF-C was found to correlate with patient poor clinical outcome (p = 0.009). The positive correlation between AT-1R and VEGF-A and VEGF-D could point to stimulatory action of Ang II on their expression what might result in augmented lymph- and angiogenesis in IDC.
authors.affiliation: Department of Histology and Embryology, Medical University, Chalubinskiego 6a, 50-368, Wroclaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Jethon
authors.forename: Bartosz
authors.initials: B
authors.lastname: Pula
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piotrowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojnar
authors.forename: Janusz
authors.initials: J
authors.lastname: Rys
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okolow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D042583:Lymphangiogenesis; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000096:biosynthesis* / Q000378:metabolism; D018709:Statistics, Nonparametric; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000378:metabolism; D042643:Vascular Endothelial Growth Factor D / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D044140:Receptor, Angiotensin, Type 1; D042461:Vascular Endothelial Growth Factor A; D042643:Vascular Endothelial Growth Factor D