title: Nonprocessed adipose tissue graft in the treatment of dehiscence bone defects in rabbit tibiae:  a pilot study.
abstract: OBJECTIVE
  To evaluate the bone repair of surgically created dehiscence-type defects (3 × 5 mm) around dental implants in rabbit tibia using nonprocessed adipose tissue graft or autogenous bone graft.
  
  
  METHODS
  The bone defects were randomly assigned to 3 groups: blood clot (C), autogenous bone (AB), and nonprocessed adipose tissue (AT). After 3 months, the animals were euthanized. Histomorphometric analyses were performed, and the results were analyzed with analysis of variance and Tukey tests (P ≤ 0.05). Statistics were performed for the percentage of the bone-to-implant contact (BIC) and bone area (BA) within the limits of the threads.
  
  
  RESULTS
  The results for BIC in the AT (37.75% ± 28.03%) and C (40.57 ± 13.71%) groups were statistically similar, whereas the AB group had the greatest percentage of BIC (83.37% ± 11.85%). For all groups, the BA percentage was similar (61.48% ± 30.89% in AT; 72.90% ± 14.10% in C; 84.23% ± 11.96% in AB), with no statistically significant differences.
  
  
  CONCLUSIONS
  Nonprocessed adipose tissue is not a comparable substitute for autogenous bone in the treatment of dehiscence bone defects around titanium dental implants.
authors.affiliation: Positivo University, Curitiba, Paraná, Brazil.
authors.forename: Fernanda Brugin
authors.initials: FB
authors.lastname: Matsubara
authors.forename: Diogo Godoy
authors.initials: DG
authors.lastname: Zanicotti
authors.forename: João César
authors.initials: JC
authors.lastname: Zielak
authors.forename: Allan Fernando
authors.initials: AF
authors.lastname: Giovanini
authors.forename: Carla Castiglia
authors.initials: CC
authors.lastname: Gonzaga
authors.forename: Cícero
authors.initials: C
authors.lastname: de Andrade Urban
authors.forename: Tatiana Miranda
authors.initials: TM
authors.lastname: Deliberador
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000637:transplantation*; D016301:Alveolar Bone Loss / Q000209:etiology / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation; D015921:Dental Implants / Q000009:adverse effects; D008297:Male; D059630:Mesenchymal Stem Cells; D016348:Osseointegration; D010865:Pilot Projects; D011817:Rabbits; D011897:Random Allocation; D013529:Surgical Wound Dehiscence / Q000601:surgery; D013977:Tibia / Q000601:surgery
chemical_list: D015921:Dental Implants