title: Oral cyclosporine therapy for refractory severe vernal keratoconjunctivitis.
abstract: We report the success of oral cyclosporine therapy in a patient with severe vision-threatening vernal keratoconjunctivitis. A child presented with severe allergy which was not controlled with topical steroids, cyclosporine and mast cell stabilizers. Oral steroids were required repeatedly to suppress inflammation. Child showed a dramatic improvement and stabilization with oral cyclosporine therapy. Oral cyclosporine therapy can be tried in severe vision-threatening allergy refractory to conventional therapy.
authors.affiliation: Gokhale Eye Hospital and Eyebank, Dadar, Mumbai, Maharashtra, India.
authors.forename: Nikhil S
authors.initials: NS
authors.lastname: Gokhale
authors.forename: Rohini
authors.initials: R
authors.lastname: Samant
authors.forename: Vishnu
authors.initials: V
authors.lastname: Sharma
mesh_terms: D000284:Administration, Oral; D002648:Child; D003228:Conjunctiva / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000188:drug therapy*; D003315:Cornea / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000187:drug effects*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine