title: [Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration].
abstract: Cytoskeletal polymers play pleiotropic roles in neuroglial morphogenesis, intracellular transport, organization of pre- and post-synaptic scaffolds, etc. Thus, neuroglial dysfunction and degeneration are often accompanied by abnormalities in microtubules, actin and/or intermediate filament systems. Although our understanding of an unconventional cytoskeletal system composed of the septin family of GTP-binding proteins is far behind, recent studies have been revealing that qualitative and/or quantitative abnormalities of septins are also associated with neurodegenerative disorders including hereditary neuralgic amyotrophy, Parkinson disease, schizophrenia and bipolar disorder. A better understanding of the physiological and pathophysiological roles of the septin system should help develop useful biomarkers and therapeutic strategies for these diseases.
authors.affiliation: Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan. kinoshita.makoto@c.mbox.nayoya-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000209:etiology*; D010300:Parkinson Disease / Q000209:etiology; D058112:Septins / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D051844:alpha-Synuclein / Q000502:physiology
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D051844:alpha-Synuclein; C115474:Sept4 protein, mouse; D058112:Septins; D004298:Dopamine