title: Interplay between lipids and branched-chain amino acids in development of insulin resistance.
abstract: Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology, Duke University Medical Center, Durham, NC 27704, USA. chris.newgard@duke.edu
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Newgard
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008659:Metabolic Diseases / Q000378:metabolism
chemical_list: D000597:Amino Acids, Branched-Chain