title: The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g.
abstract: OBJECTIVE
  To evaluate the association between respiratory tract Ureaplasma urealyticum (Uu) colonization and development of retinopathy of prematurity (ROP) requiring treatment.
  
  
  METHODS
  The infants with birthweight (BW) ≤1250 g born in a third-level neonatal intensive care unit between March 2009 and May 2010 were prospectively identified. Nasopharyngeal swabs for Uu colonization were taken in postnatal first 3 days. Culture-positive patients were reevaluated on the twelfth day by nasopharyngeal swabs for Uu. The primary outcome was to define whether there was an association between respiratory tract Uu colonization and severe ROP requiring treatment. Independent sample's t-test or Mann-Whitney U-test was used to compare continuous variables and Chi-square test or Fisher's exact test for categorical variables. Multivariate (backward) logistic regression analysis was performed to simultaneously measure the influence of the independent variables with ROP as the dependent variable.
  
  
  RESULTS
  A total of 25 (12.1%) infants developed severe ROP requiring treatment among 206 infants who underwent ROP screening. Mean BW and gestational age of total cohort were 1013±159 g and 27.9±1.6 weeks, respectively. Multivariate analysis demonstrated that BW (OR: 0.64 (95% Cl 0.47-0.88); P=0.006), duration of mechanical ventilation (OR: 1.17 (95% Cl 1.06-1.28); P=0.001), premature rupture of membrane >18 h (OR: 3.83 (95% Cl 1.2-12.2); P=0.02), and Uu positivity in both cultures (OR: 5.02 (95% Cl 1.8-13.9); P=0.002) were independent risk factors for the development of severe ROP requiring treatment.
  
  
  CONCLUSIONS
  Respiratory tract colonization with Uu was independently associated with severe ROP requiring treatment.
authors.affiliation: Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Neonatal Intensive Care Unit, Ankara, Turkey. ramazanoz@yahoo.com.tr
authors.forename: R
authors.initials: R
authors.lastname: Ozdemır
authors.forename: F N
authors.initials: FN
authors.lastname: Sarı
authors.forename: Z O
authors.initials: ZO
authors.lastname: Tunay
authors.forename: O
authors.initials: O
authors.lastname: Erdeve
authors.forename: F E
authors.initials: FE
authors.lastname: Canpolat
authors.forename: S S
authors.initials: SS
authors.lastname: Oguz
authors.forename: N
authors.initials: N
authors.lastname: Uras
authors.forename: U
authors.initials: U
authors.lastname: Dılmen
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000382:microbiology; D016015:Logistic Models; D008297:Male; D009305:Nasopharynx / Q000382:microbiology; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000382:microbiology*; D012178:Retinopathy of Prematurity / Q000209:etiology*; D016869:Ureaplasma Infections / Q000150:complications*; D016990:Ureaplasma urealyticum / Q000302:isolation & purification*