title: Clofazimine-induced enteropathy in treatment-resistant nodular vasculitis.
abstract: We report a chronic case of nodular vasculitis that responded to oral clofazimine 300 mg daily. The condition had previously responded to moderate dose oral prednisolone, 50 mg daily, but would recur with weaning. Multiple corticosteroid-sparing agents were trialled, however these were either ineffective or poorly tolerated. The introduction of clofazimine enabled prednisolone dose reduction, not achieved with other agents, to 22.5 mg daily, and was associated with complete suppression of disease activity. Unfortunately the patient developed a clofazimine-induced enteropathy and the treatment was ceased after almost 2 years of therapy. Cessation of clofazimine was associated with a flare of the condition. Clofazimine should be considered as a corticosteroid-sparing agent in resistant cases of nodular vasculitis. Clinicians should be aware of clofazimine-induced enteropathy as a potentially serious complication of the therapy.
authors.affiliation: Department of Dermatology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia. violet.kieu@gmail.com
authors.forename: Violet
authors.initials: V
authors.lastname: Kieu
authors.forename: Richard
authors.initials: R
authors.lastname: Williams
authors.forename: Prue
authors.initials: P
authors.lastname: Hill
authors.forename: Rob
authors.initials: R
authors.lastname: Kelly
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000627:therapeutic use; D002991:Clofazimine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004891:Erythema Induratum / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced*; D011239:Prednisolone / Q000627:therapeutic use; D017211:Treatment Failure; D014657:Vasculitis / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000995:Antitubercular Agents; D005938:Glucocorticoids; D011239:Prednisolone; D002991:Clofazimine