title: An efficient and recyclable catalyst for the cleavage of tert-butyldiphenylsilyl ethers.
abstract: An efficient, chemoselective, and environment-friendly method for the deprotection of tert-butyldiphenylsilyl ethers mediated by triflic acid supported on silica gel is reported. A wide range of tert-butyldiphenylsilyl ethers derived from carbohydrate and saponin residues can be smoothly cleaved in the presence of various types of other protecting groups in good to excellent yields in acetonitrile. This heterogeneous reaction does not require aqueous workup, and the supported catalyst can be readily recycled.
authors.affiliation: Key Lab of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Yan
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000097:Acetonitriles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D008968:Molecular Conformation; D012821:Silanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D000097:Acetonitriles; D004987:Ethers; D005782:Gels; D008698:Mesylates; D012821:Silanes; D012822:Silicon Dioxide; C012077:trifluoromethanesulfonic acid; C032159:acetonitrile