title: Soluble urokinase receptor and focal segmental glomerulosclerosis.
abstract: OBJECTIVE
  We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR).
  
  
  RESULTS
  Primary FSGS can affect both children and adults. The disease can recur after kidney transplantation suggesting the involvement of a causative circulating factor. Recent work suggests that approximately two-thirds of FSGS patients have elevated levels of serum suPAR, which confers risk to both native and posttransplant FSGS.
  
  
  CONCLUSIONS
  Future studies that are geared to understand the clinical implications of high suPAR levels in native FSGS as well as in the pretransplant and posttransplant setting will allow for better patient risk stratification and more targeted treatment options.
authors.affiliation: Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA. jreiser@med.miami.edu
authors.forename: Jochen
authors.initials: J
authors.lastname: Reiser
authors.forename: Changli
authors.initials: C
authors.lastname: Wei
authors.forename: James
authors.initials: J
authors.lastname: Tumlin
mesh_terms: D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D016030:Kidney Transplantation; D050199:Podocytes / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood / Q000378:metabolism*; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D016023:Integrins; D055293:Receptors, Urokinase Plasminogen Activator