title: Mutual remodeling and conformation grid: a mediator code?
abstract: How does a common RNA polymerase II apparatus generate a complex pattern of transcripts in response to many gene-specific transcription factors and in accordance with cell's state? In this issue of Structure, Cai et al. reveal that the process involves coordinated conformational changes in Pol II and Mediator.
authors.affiliation: Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Meyer
authors.forename: Jianhua
authors.initials: J
authors.lastname: Fu