title: Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives.
abstract: A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.
authors.affiliation: AE Arbuzov Institute of Organic and Physical Chemistry, The Russian Academy of Sciences, Arbuzov str 8, Kazan 420088, Russian Federation. mshulaeva@iopc.ru
authors.forename: M M
authors.initials: MM
authors.lastname: Shulaeva
authors.forename: S G
authors.initials: SG
authors.lastname: Fattakhov
authors.forename: L F
authors.initials: LF
authors.lastname: Saifina
authors.forename: R V
authors.initials: RV
authors.lastname: Chestnova
authors.forename: R Sh
authors.initials: RSh
authors.lastname: Valijev
authors.forename: D N
authors.initials: DN
authors.lastname: Mingaleev
authors.forename: A D
authors.initials: AD
authors.lastname: Voloshina
authors.forename: V S
authors.initials: VS
authors.lastname: Reznik
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D060326:Chemistry Techniques, Synthetic; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D013451:Sulfonic Acids; D014227:Triazines; C509473:isocyanuric acid