title: Measurement of the absorbed dose distribution near an 192Ir intravascular brachytherapy seed using a high-spatial-resolution gel dosimetry system.
abstract: The absorbed dose distribution at sub-millimeter distances from the Best single (192)Ir intravascular brachytherapy seed was measured using a high-spatial-resolution gel dosimetry system. Two gel phantoms from the same batch were used; one for the seed irradiation and one for calibration. Since the response of this gel is energy independent for photons between 20 and 1250 keV, the gel was calibrated using a narrowly collimated (60)Co gamma-ray beam (cross-sectional area ~1 cm(2)). A small format laser computed tomography scanner was used to acquire the data. The measurements were carried out with a spatial resolution of 100 µm in all dimensions. The seed was calibrated at NIST in terms of air-kerma strength. The absorbed dose rate as well as the radial dose function, g(L)(r), was measured for radial distances between 0.6 and 12.6 mm from the seed center. The dose rate constant was measured, yielding a value of Λ = (1.122 ± 0.032) cGy h(-1) U(-1), which agrees with published data within the measurement uncertainty. For distances between 0.6 and 1.5 mm, g(L)(r) decreases from a maximum value of 1.06 down to 1.00; between 1.5 and 6.7 mm, an enhancement is clearly observed with a maximum value around 1.24 and beyond 6.7 mm, g(L)(r) has an approximately constant value around 1.0, which suggests that this seed can be considered as a point source only at distances larger than 6.7 mm. This latter observation agrees with data for the same seed reported previously using Gafchromic film MD-55-2. Additionally, published Monte Carlo (MC) calculations have predicted the observed behavior of the radial dose function resulting from the absorbed dose contributions of beta particles and electrons emitted by the (192)Ir seed. Nonetheless, in the enhancement region, MC underestimates the dose by approximately 20%. This work suggests that beta particles and electrons emitted from the seed make a significant contribution to the total absorbed dose delivered at distances near the seed center (less than 6 mm) and therefore cannot be neglected, given the dimensions of blood vessel walls.
authors.affiliation: Instituto de Física, Universidad Nacional Autónoma de México, Distrito Federal, México. massillon@fisica.unam.mx
authors.forename: G
authors.initials: G
authors.lastname: Massillon-JL
authors.forename: R
authors.initials: R
authors.lastname: Minniti
authors.forename: M G
authors.initials: MG
authors.lastname: Mitch
authors.forename: C G
authors.initials: CG
authors.lastname: Soares
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D057510:Endovascular Procedures / Q000379:methods*; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage
chemical_list: D007496:Iridium Radioisotopes