title: Trimetazidine in the prevention of contrast induced nephropathy after coronary angiogram.
abstract: This prospective randomized, controlled trial was done to evaluate the efficacy of trimetazidine in the prevention of contrast induced nephropathy in patients with raised serum creatinine levels undergoing coronary angiogram. This study was performed in the Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from April 2009 to March 2010. Contrast-induced nephropathy (CIN) is a serious complication of coronary angiography that is associated with considerably increased mortality and morbidity, including the need for short-term haemodialysis, extended hospitalisation and permanent impairment of renal function. Trimetazidine (TMZ) has been described as a cellular anti-ischaemic agent. This study was trial with 400 patients. Among them 200 patients treated with trimetazidine plus hydration with normal saline and 200 patients (control) given hydration by normal saline only. It was found that the incidence of CIN was significantly (p<0.05) reduced by trimetazidine administration with saline in comparison with saline alone in patients undergoing coronary angiogram (4% vs. 14%).
authors.affiliation: Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
authors.forename: M M
authors.initials: MM
authors.lastname: Rahman
authors.forename: S S
authors.initials: SS
authors.lastname: Haque
authors.forename: B
authors.initials: B
authors.lastname: Rokeya
authors.forename: M A
authors.initials: MA
authors.lastname: Siddique
authors.forename: S K
authors.initials: SK
authors.lastname: Banerjee
authors.forename: S A
authors.initials: SA
authors.lastname: Ahsan
authors.forename: F
authors.initials: F
authors.lastname: Rahman
authors.forename: M
authors.initials: M
authors.lastname: Mahmood
authors.forename: K
authors.initials: K
authors.lastname: Ahmed
authors.forename: M M
authors.initials: MM
authors.lastname: Bhuiyan
authors.forename: A I
authors.initials: AI
authors.lastname: Joarder
authors.forename: R C
authors.initials: RC
authors.lastname: Debnath
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012965:Sodium Chloride / Q000627:therapeutic use; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D012965:Sodium Chloride; D003404:Creatinine; D014292:Trimetazidine