title: Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa.
abstract: The aim of this study was to investigate the prevalence of hyperinsulinaemia in a group of normozoospermic donors and the influence of insulin levels on in vitro fertilisation (IVF) outcome. Fasting insulin and 2 h post-eating insulin levels were determined for a group of thirty-four sperm donors. They were divided into three groups according to their insulin profiles. The association between insulin levels and embryo quality was determined in a clinical study for the different groups. The prevalence of raised insulin in the donor group was 44% with a 95% confidence interval of 27.2% and 62.1%. Donors with normal insulin levels produced more good quality blastocysts in the IVF programme than those with abnormal insulin levels. These differences were not statistically significant (P=0.8638). Embryo quality in an IVF programme may be influenced by male insulin levels. The role of insulin in male fertility needs to be investigated.
authors.affiliation: Medfem Clinic, Cramerview, Gauteng, South Africa. ivflab@medfem.co.za
authors.forename: E
authors.initials: E
authors.lastname: Bosman
authors.forename: A D
authors.initials: AD
authors.lastname: Esterhuizen
authors.forename: F A
authors.initials: FA
authors.lastname: Rodrigues
authors.forename: P J
authors.initials: PJ
authors.lastname: Becker
authors.forename: W A
authors.initials: WA
authors.lastname: Hoffmann
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology; D015992:Body Mass Index; D005215:Fasting; D005298:Fertility / Q000502:physiology; D005307:Fertilization in Vitro; D006801:Humans; D006946:Hyperinsulinism / Q000453:epidemiology*; D007328:Insulin / Q000097:blood / Q000502:physiology; D008019:Life Style; D008297:Male; D019518:Postprandial Period; D055101:Semen Analysis; D013020:South America / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D007328:Insulin