title: Ocular manifestations of acquired immunodeficiency syndrome in Korea.
abstract: The clinical features of HIV/AIDS-related ocular manifestations in Korean patients were investigated in this study. Data on 200 consecutive Korean patients diagnosed with AIDS who visited the Seoul National University Hospital from January 2003 to June 2008 were reviewed. Fifty-seven patients (28.5%) had ocular manifestations, and they showed significantly lower CD4+ T cell count than patients without ocular manifestations. Among them, 23 (40.3%) patients showed retinal microvasculopathy, and 22 (38.5%) patients showed cytomegalovirus (CMV) retinitis. Other manifestations included retinal vein occlusion (n = 4), herpes zoster ophthalmicus (n = 4), syphilitic uveitis (n = 2), acute retinal necrosis (n = 1), and progressive outer retinal necrosis (n = 1). The mean CD4+ lymphocyte counts of the patients with retinal microvasculopathy and cytomegalovirus retinitis were 108.5 cells/µL and 69.4 cells/µL, respectively. In conclusion, ocular manifestations including CMV retinitis are common complications in Korean patients with AIDS even in the era of highly active anti-retroviral therapy. Compared to previous reports in western countries, prevalence of CMV retinitis is relatively low and CD4+ lymphocytes count at the time of diagnosis is relatively high.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Park
authors.forename: Hyeong Gon
authors.initials: HG
authors.lastname: Yu
authors.forename: Nam Joong
authors.initials: NJ
authors.lastname: Kim
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.forename: Myoung-don
authors.initials: MD
authors.lastname: Oh
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology*; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D017726:Cytomegalovirus Retinitis / Q000453:epidemiology / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology; D015828:Eye Infections, Viral / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012173:Retinitis / Q000209:etiology; D014605:Uveitis / Q000209:etiology; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents