title: Antimicrobial properties of electrically formed elastomeric polyurethane-copper oxide nanocomposites for medical and dental applications.
abstract: With the rapidly advancing field of nanotechnology having an impact in several areas interfacing life and physical sciences, the potential applications of nanoparticles as antimicrobial agents have been realized and offer great opportunities in addressing several viral and bacterial outbreak issues. Polyurethanes (PUs) are a diverse class of polymeric materials which also have applications in several areas of biomedical science ranging from blood contact devices to implantable dental technologies. In this report, copper oxide (CuO) nanoparticles (mean size ∼50 nm) are embedded into a PU matrix via two electrical fabrication processes. To elucidate the antimicrobial activity, a range of different loading compositions of CuO within the PU matrix (0%, 1%, 5%, and 10% w/w) are electrospun to form thin porous films (thickness < 10 μm). After washing, the films are tested for their antimicrobial properties against methicillin-resistant Staphylococcus aureus (MRSA). Significant reduction of populations was demonstrated with 10% w/w CuO over a 4-h period. This approach demonstrates the potential of generating tailored antimicrobial structures for a host of applications, such as designer filters, patterned coatings, breathable fabrics, adhesive films (as opposed to sutures), and mechanically supporting structures.
authors.affiliation: School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
authors.forename: Z
authors.initials: Z
authors.lastname: Ahmad
authors.forename: M A
authors.initials: MA
authors.lastname: Vargas-Reus
authors.forename: R
authors.initials: R
authors.lastname: Bakhshi
authors.forename: F
authors.initials: F
authors.lastname: Ryan
authors.forename: G G
authors.initials: GG
authors.lastname: Ren
authors.forename: F
authors.initials: F
authors.lastname: Oktar
authors.forename: R P
authors.initials: RP
authors.lastname: Allaker
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D020724:Elastomers / Q000737:chemistry / Q000494:pharmacology*; D008567:Membranes, Artificial; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D050296:Microbial Viability / Q000187:drug effects; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011140:Polyurethanes / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D020724:Elastomers; D008567:Membranes, Artificial; D011140:Polyurethanes; D003300:Copper; C000520:cuprous oxide