title: Sexual dimorphism in rodent models of hypertension and atherosclerosis.
abstract: Approximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect, investigation of the mechanisms underlying the protection that premenopausal females enjoy from cardiovascular-related disease and mortality is of interest. In this review, we discuss the essential role that rodent animal models play in enabling this field of research. In particular, we focus our discussion on models of hypertension and atherosclerosis.
authors.affiliation: William Harvey Research Institute, Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Bubb
authors.forename: Rayomand S
authors.initials: RS
authors.lastname: Khambata
authors.forename: Amrita
authors.initials: A
authors.lastname: Ahluwalia
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012377:Rodentia; D012737:Sex Factors