title: Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.
abstract: Functions of adrenal medulla, particularly synthesis of catecholamine, are under the control of glucocorticoids produced by the cortex. To further investigate whether development/differentiation of the adrenal medulla is associated with proper organization of the adrenal cortex, we examined development of the medulla in four different mouse models with various defects in the adrenal cortex. By using the Sf1/Cre mouse line that inactivates/activates genes in Steroidogenic factor 1 (SF1)-positive cells of the fetal adrenal cortex, we produced mice that exhibit either (1) cortex hypoplasia, (2) progressive degeneration of fetal adrenal cortex, (3) cortex dysgenesis, or (4) cortex-medulla disorganization. The formation of phenylethanolamine N-methyltransferase (PNMT)-positive medulla in all models indicates that differentiation of adrenal medulla is independent of the growth of adrenal cortex. However, the misplaced/dysgenic medulla in embryos where β-catenin expression is altered, suggests that the β-catenin pathway in the adrenal cortical cells plays an indirect role in controlling proper organization of the adrenal medulla.
authors.affiliation: Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL, USA.
authors.forename: Chen-Che Jeff
authors.initials: CC
authors.lastname: Huang
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Humphrey Hung-Chang
authors.initials: HH
authors.lastname: Yao
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism / Q000473:pathology*; D000313:Adrenal Medulla / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D019426:Integrases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D010641:Phenotype; D043244:Ribonuclease III / Q000378:metabolism; D054339:Steroidogenic Factor 1 / Q000378:metabolism; D051176:beta Catenin / Q000172:deficiency / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; C465570:Shh protein, mouse; D054339:Steroidogenic Factor 1; D051176:beta Catenin; C045073:Cre recombinase; D019426:Integrases; C509781:Dicer1 protein, mouse; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases