title: Lack of an association between obsessive-compulsive disorder and polymorphisms in the 3' untranslated region of GRIN2B in a Chinese Han population.
abstract: Previous investigations have provided evidence that some polymorphisms in the 3' untranslated region (3'-UTR) of GRIN2B are associated with susceptibility to obsessive-compulsive disorder (OCD). We evaluated the genetic contribution of the rs1805502, rs1805476 and rs890 polymorphisms in the 3'-UTR of GRIN2B in 206 OCD patients and 413 controls in a Chinese Han population, and found no significant differences in genotypic and allelic frequencies between OCD cases and the controls. Our results suggest the lack of an association between OCD and polymorphisms in the 3'-UTR of GRIN2B in a Chinese Han population.
authors.affiliation: The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuping
authors.initials: Y
authors.lastname: Sun
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D020413:3' Untranslated Regions; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate