title: Somatosensory High Frequency Oscillations reflect clinical fluctuations in migraine.
abstract: OBJECTIVE
  It has been demonstrated that the early part of 600 Hz High Frequency Oscillations (HFOs), probably generated in the terminal part of thalamo-cortical somatosensory radiations, are abnormally reduced between attacks in migraineurs. We aimed at verifying whether spontaneous clinical fluctuations in migraine are correlated to HFO changes.
  
  
  METHODS
  We recorded somatosensory evoked potentials in 28 migraine patients. Clinical fluctuations (number of attacks in the 6 months preceding and following the test) were correlated to the HFOs' amplitudes. Moreover, eight out of 28 patients underwent a longer follow-up, including HFO control and clinical observation during the 12 months following the baseline recording.
  
  
  RESULTS
  The amplitude of early presynaptic HFOs was significantly correlated to the clinical evolution, since spontaneous worsening was associated with reduced presynaptic HFOs, whereas spontaneous improvement was associated with enhanced presynaptic HFOs (correlation test, p<0.05). No correlation was found between the amplitude of postsynaptic HFOs and clinical fluctuations. Patients undergoing longer follow-up showed substantially unchanged HFOs, accordingly with their stable clinical condition.
  
  
  CONCLUSIONS
  HFOs' enhancement in spontaneously improved patients can reflect the increased activity of brainstem arousal related structures, which in turn increases the thalamo-cortical drive and the cortical lateral inhibition mediated by GABAergic interneurons.
  
  
  CONCLUSIONS
  HFOs' recording could represent a useful tool in the functional assessment of migraine.
authors.affiliation: Department of Neurosciences, Catholic University, Rome, Italy. drestuccia@rm.unicatt.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Restuccia
authors.forename: Catello
authors.initials: C
authors.lastname: Vollono
authors.forename: Ivana
authors.initials: I
authors.lastname: Del Piero
authors.forename: Lucia
authors.initials: L
authors.lastname: Martucci
authors.forename: Sergio
authors.initials: S
authors.lastname: Zanini
mesh_terms: D000328:Adult; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D015203:Reproducibility of Results; D013003:Somatosensory Cortex / Q000503:physiopathology*