title: Closed-loop insulin delivery in type 1 diabetes.
abstract: Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.
authors.affiliation: Institute of Metabolic Science, Addenbrookes Hospital, University of Cambridge, Box 289, Level 4, Cambridge CB2 0QQ, UK.
authors.forename: Hood
authors.initials: H
authors.lastname: Thabit
authors.forename: Roman
authors.initials: R
authors.lastname: Hovorka
mesh_terms: D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007332:Insulin Infusion Systems
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin