title: Liver regeneration after liver transplantation.
abstract: OBJECTIVE
  The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation.
  
  
  METHODS
  Relevant studies were reviewed using Medline, PubMed and Springer databases.
  
  
  RESULTS
  A variety of cytokines (such as interleukin-6 and tumor necrosis factor-α), growth factors (like hepatocyte growth factor and transforming growth factor-α) and cells are involved in liver regeneration. Several factors affect liver regeneration after transplantation such as ischemic injury, graft size, immunosuppression, steatosis, donor age and viral hepatitis.
  
  
  CONCLUSIONS
  Liver regeneration has been studied for many years. However, further research is essential to reveal the complex processes affecting liver regeneration, which may provide novel strategies in the management of liver transplantation recipients and donors.
authors.affiliation: Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: A
authors.initials: A
authors.lastname: Taki-Eldin
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: H-Y
authors.initials: HY
authors.lastname: Xie
authors.forename: S-S
authors.initials: SS
authors.lastname: Zheng
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008115:Liver Regeneration; D016031:Liver Transplantation; D016328:NF-kappa B / Q000502:physiology; D050796:STAT3 Transcription Factor / Q000502:physiology; D014019:Tissue Donors
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D050796:STAT3 Transcription Factor