title: Successful treatment of multiple basaliomas with bleomycin-based electrochemotherapy: a case series of three patients with Gorlin-Goltz syndrome.
abstract: Gorlin-Goltz syndrome is a rare multisystemic disease, characterized by numerous basal cell carcinomas. The ideal approach for patients with the syndrome would be a treatment with a high cure rate, minimal scarring, short healing time and mild side-effects. Electrochemo-therapy is a novel therapeutic option that ablates tumours with electrical current and simultaneously administered anticancer drugs. Three patients with Gorlin-Goltz syndrome were treated with electrochemotherapy using intravenous bleomycin. Clinical response was obtained in 98 (99%) of the lesions, 86 (87%) of them showed complete response. In 2 tumours, regression was confirmed with histological examination. Long-term cosmetic results were excellent. We consider electrochemotherapy to be an additional tool in the therapeutic armamentarium for Gorlin-Goltz syndrome, and suggest using it as early as possible in selected patients to avoid disfiguring scarring.
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary. plasztika@yahoo.com
authors.forename: Erika
authors.initials: E
authors.lastname: Kis
authors.forename: Eszter
authors.initials: E
authors.lastname: Baltás
authors.forename: Agnes
authors.initials: A
authors.lastname: Kinyó
authors.forename: Erika
authors.initials: E
authors.lastname: Varga
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Nagy
authors.forename: Rolland
authors.initials: R
authors.lastname: Gyulai
authors.forename: Lajos
authors.initials: L
authors.lastname: Kemény
authors.forename: Judit
authors.initials: J
authors.lastname: Oláh
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D001761:Bleomycin / Q000008:administration & dosage* / Q000009:adverse effects; D002921:Cicatrix / Q000209:etiology; D053672:Electrochemotherapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin