title: Synthesis of core-shell coordination polymer nanoparticles (CPNs) for pH-responsive controlled drug release.
abstract: Four types of physiologically unstable anticancer "drug-metal" CPNs were "shelled" with pH-responsive "ligand-metal" CPs, which gives rise to a significant release of drug molecules under designated pH conditions and exhibited a higher cytotoxicity against HeLa cells than core CPNs and free drug.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Cao
authors.forename: Shunai
authors.initials: S
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004337:Drug Carriers; D011108:Polymers