title: A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.
abstract: A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.
authors.affiliation: Département de Chimie, CINaM CNRS UMR 7325, Aix-Marseille Université, Marseille, France.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Olivier
authors.initials: O
authors.lastname: Demaria
authors.forename: Jingjie
authors.initials: J
authors.lastname: Tang
authors.forename: Palma
authors.initials: P
authors.lastname: Rocchi
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Juan L
authors.initials: JL
authors.lastname: Iovanna
authors.forename: Lena
authors.initials: L
authors.lastname: Alexopoulou
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D051199:Toll-Like Receptor 7 / Q000235:genetics / Q000378:metabolism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D009705:Nucleosides; C477038:Tlr7 protein, mouse; D051199:Toll-Like Receptor 7; D014230:Triazoles