title: Malignant tumors of the sinonasal tract in the pediatric population.
abstract: CONCLUSIONS
  Sarcoma and lymphoma comprised 75% of 20 cases of pediatric sinonasal malignancies. As regards treatment, all 20 patients received chemotherapy and 6 patients (30%) underwent surgery. The overall 5-year survival rate was 52%, with favorable outcome for solid tumors compared with lymphoma.
  
  
  OBJECTIVE
  We aimed to investigate the clinical features and treatment outcomes of sinonasal malignancies in 20 pediatric patients.
  
  
  METHODS
  Clinical features were evaluated and tumors were staged according to the staging system for each histologic type.
  
  
  RESULTS
  The 20 patients consisted of 12 males and 8 females, ranging in age from 1 to 16 years, with a median age of 9.6 years at diagnosis. More than half of the patients presented with nasal obstruction as the primary symptom, and mean symptom duration to diagnosis was 5.4 months. Primary tumor sites included the paranasal sinuses alone in four patients, the nasal cavity alone in eight, and both in eight. Eight tumors were sarcomas and seven were lymphomas. The remaining tumors included three olfactory neuroblastomas and two primitive neuroectodermal tumors. The main treatment modality was chemotherapy rather than surgery. The overall survival rate was 52%, and patients with solid tumors survived significantly longer than those with lymphoma (p = 0.02).
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Jong Sook
authors.initials: JS
authors.lastname: Yi
authors.forename: Gye Song
authors.initials: GS
authors.lastname: Cho
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Shim
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Min
authors.forename: Yoo-Sam
authors.initials: YS
authors.lastname: Chung
authors.forename: Bong-Jae
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009669:Nose Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate / Q000639:trends