title: The effect of body mass index on spinal anaesthesia for total knee replacement arthroplasty: a dose-response study.
abstract: The aim of this study was to compare the duration of spinal anaesthesia in obese and non-obese subjects. We also quantified the effect of body mass index (BMI) on spinal anaesthesia by comparing the median effective dose (ED50) of intrathecal hyperbaric bupivacaine required in the two cohorts. One hundred and eight patients undergoing elective total knee replacement arthroplasty under combined spinal-epidural anaesthesia were enrolled as a non-obese group (BMI <27.5 kg/m(2)) or obese (O) group (BMI ≥ 27.5 kg/m(2)). Each group was further subdivided by bupivacaine doses of 6, 7, 8, 9, 10 or 11 mg, respectively. Anaesthesia was deemed successful if a bilateral T12 sensory block occurred within 15 minutes of intrathecal drug administration and epidural supplementation was not required. The ED50 for successful anaesthesia and that for successful block of tourniquet pain were determined separately by probit regression analysis. Although the analgesic duration was prolonged with higher doses of bupivacaine in group O, the ED50 for successful anaesthesia did not differ between groups. However, the incidence of tourniquet pain was lower in group O and the ED50 for block of tourniquet pain was less in group O. This study suggests that bupivacaine dose reduction is not necessary, but analgesic duration may be prolonged in patients with higher BMI. These patients require careful consideration of spinal anaesthetic dose to minimise the risk of unnecessary prolongation of anaesthesia.
authors.affiliation: Department of Anaesthesia and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: W H
authors.initials: WH
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Ko
authors.forename: H J
authors.initials: HJ
authors.lastname: Ahn
authors.forename: S K
authors.initials: SK
authors.lastname: Park
authors.forename: M S
authors.initials: MS
authors.lastname: Gwak
authors.forename: G S
authors.initials: GS
authors.lastname: Kim
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage; D019645:Arthroplasty, Replacement, Knee; D015992:Body Mass Index; D002045:Bupivacaine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007022:Hypotension / Q000503:physiopathology; D016015:Logistic Models; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009765:Obesity / Q000150:complications; D011446:Prospective Studies; D012044:Regression Analysis; D014111:Tourniquets
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine