title: Effect of nitric oxide inhibition on blood pressure and renal sodium handling: a dose-response study in healthy man.
abstract: Nitric oxide (NO) is a ubiquitous vasodilator and an important regulator of renal sodium excretion. To further investigate the role of NO in renal sodium handling, we studied the effects of the NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), in a crossover dose-response study. During NO inhibition mean arterial pressure increased dose-dependently and reached a plateau after 20 minutes of infusion. On the contrary, the fractional excretion of sodium was reduced equally in all three L-NMMA doses. This indicates that sodium excretion is highly sensitive to even small changes in renal NO bioavailability in healthy human.
authors.affiliation: Department of Medical Research, Holstebro Hospital, Holstebro, Denmark. thomaslse@rm.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Larsen
authors.forename: Frank Holden
authors.initials: FH
authors.lastname: Mose
authors.forename: Jesper Noergaard
authors.initials: JN
authors.lastname: Bech
authors.forename: Erling Bjerregaard
authors.initials: EB
authors.lastname: Pedersen
mesh_terms: D000293:Adolescent; D000328:Adult; D062186:Arterial Pressure / Q000187:drug effects*; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D012084:Renin-Angiotensin System / Q000187:drug effects; D016037:Single-Blind Method; D012982:Sodium, Dietary / Q000378:metabolism; D019323:omega-N-Methylarginine / Q000008:administration & dosage* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D007552:Isotonic Solutions; D012982:Sodium, Dietary; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase