title: Insights into the Plasmodium falciparum schizont phospho-proteome.
abstract: It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.
authors.affiliation: Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands. e.lasonder@ncmls.ru.nl
authors.forename: Edwin
authors.initials: E
authors.lastname: Lasonder
authors.forename: Moritz
authors.initials: M
authors.lastname: Treeck
authors.forename: Mahmood
authors.initials: M
authors.lastname: Alam
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Tobin
mesh_terms: D010750:Phosphoproteins / Q000032:analysis*; D010963:Plasmodium falciparum / Q000737:chemistry* / Q000502:physiology; D020543:Proteome / Q000032:analysis*; D015800:Protozoan Proteins / Q000032:analysis*; D052939:Schizonts / Q000737:chemistry* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D010750:Phosphoproteins; D020543:Proteome; D015800:Protozoan Proteins