title: Conversion of IGT to type 2 diabetes mellitus is associated with incident cases of hypertension:  a post-hoc analysis of the STOP-NIDDM trial.
abstract: BACKGROUND
  Type 2 diabetes mellitus and hypertension are closely associated and contribute together to microvascular and macrovascular end-organ damage. Prevalence of hypertension is increased even in the prediabetic state. However, there is little information available about the relationship between incidence of hypertension and a deterioration of glucose tolerance from impaired glucose tolerance (IGT) to diabetes.
  
  
  METHODS
  To clarify these issues we analysed data from the Stop non insulin dependent diabetes mellitus (STOP-NIDDM) trial - a prospective interventional study for the prevention of type 2 diabetes in people with prediabetes using the alpha-glucosidase inhibitor acarbose. Hypertension was already present at study entry in 702 (51.3%) of 1368 patients who were eligible for intention-to-treat analysis.
  
  
  RESULTS
  A total of 96 out of the 666 normotensive individuals at baseline developed hypertension during the 3.3-year follow-up. The strongest risk factors for time to development of hypertension were abdominal obesity at baseline [hazard ratio 1.91, 95% confidence interval (CI) 1.19-3.05, P < 0.01] and worsening of glucose tolerance (hazard ratio 1.54, 95% CI 1.02-2.32, P < 0.05), whereas acarbose treatment reduced the risk of hypertension (hazard ratio 0.59, 95% CI 0.39-0.90, P < 0.05).
  
  
  CONCLUSIONS
  A significant relationship was found between the development of type 2 diabetes and hypertension in patients with IGT, and treatment with acarbose, which primarily improved postprandial hyperglycaemia, reduced the incidence of hypertension as well as diabetes. This suggests that the two entities shared 'common soil'.
authors.affiliation: Center for Clinical Studies, Technical University Dresden, Dresden, Germany.
authors.forename: Markolf
authors.initials: M
authors.lastname: Hanefeld
authors.forename: Frank
authors.initials: F
authors.lastname: Pistrosch
authors.forename: Carsta
authors.initials: C
authors.lastname: Koehler
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Chiasson
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D004311:Double-Blind Method; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D010919:Placebos