title: A biocatalytic redox isomerisation.
abstract: A bi-enzymatic cascade for the redox-isomerisation of allylic alcohol is presented. Coupling of an alcohol dehydrogenase to an enoate reductase has been successfully applied in one pot for the isomerisation of an allylic alcohol to the corresponding ketone. Critical parameters for yield and selectivity have been investigated.
authors.affiliation: Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628BL Delft, The Netherlands.
authors.forename: Serena
authors.initials: S
authors.lastname: Gargiulo
authors.forename: Diederik J
authors.initials: DJ
authors.lastname: Opperman
authors.forename: Ulf
authors.initials: U
authors.lastname: Hanefeld
authors.forename: Isabel W C E
authors.initials: IW
authors.lastname: Arends
authors.forename: Frank
authors.initials: F
authors.lastname: Hollmann
mesh_terms: D000426:Alcohol Dehydrogenase / Q000737:chemistry; D055162:Biocatalysis; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D008954:Models, Biological; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry
chemical_list: D020005:Propanols; C006463:allyl alcohol; D000426:Alcohol Dehydrogenase