title: Oxidative potential of some endophytic fungi using 1-indanone as a substrate.
abstract: The oxidative potential of the fungus Penicillium brasilianum, a strain isolated as an endophyte from a Meliaceae plant (Melia azedarach), was investigated using 1-indanone as a substrate to track the production of monooxygenases. The fungus produced the dihydrocoumarin from 1-indanone with the classical Baeyer-Villiger reaction regiochemistry, and (-)-(R)-3-hydroxy-1-indanone with 78% ee. Minor compounds resulting from lipase and SAM activities were also detected. The biotransformation procedures were also applied to a collection of Penicillium and Aspergillus fungi obtained from M. azedarach and Murraya paniculata. The results showed that Baeyer-Villiger were mostly active in fungi isolated from M. azedarach. Almost all of the fungi tested produced 3-hydroxy-1-indanone..
authors.affiliation: Department of Chemistry, Federal University of São Carlos, CP 676, 13.565-905 São Carlos, SP, Brazil.
authors.forename: Taicia Pacheco
authors.initials: TP
authors.lastname: Fill
authors.forename: Jose Vinicius
authors.initials: JV
authors.lastname: da Silva
authors.forename: Kleber Thiago
authors.initials: KT
authors.lastname: de Oliveira
authors.forename: Bianca Ferreira
authors.initials: BF
authors.lastname: da Silva
authors.forename: Edson
authors.initials: E
authors.lastname: Rodrigues-Fo
mesh_terms: D001230:Aspergillus / Q000302:isolation & purification / Q000378:metabolism; D001711:Biotransformation; D003374:Coumarins / Q000378:metabolism; D060026:Endophytes / Q000378:metabolism*; D007189:Indans / Q000378:metabolism*; D031586:Melia azedarach / Q000382:microbiology; D032101:Murraya / Q000382:microbiology; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D003374:Coumarins; D007189:Indans; D016877:Oxidants; C034805:3,4-dihydro-3,4-dibromo-6-bromomethylcoumarin; C013352:indacrinone