title: Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Mean platelet volume (MPV) is inversely correlated with inflammation in inflammatory bowel diseases, rheumatoid arthritis, and ankylosing spondylitis as shown in the previous studies. It has   been reported that elevated values of MPV are associated with cardiovascular diseases and stable chronic obstructive pulmonary disease (COPD). However, MPV values in acute exacerbation of COPD have not   been investigated so far.
  
  
  OBJECTIVE
  This retrospective study was conducted to investigate the relationships between MPV and acute phase reactants and functional parameters during COPD exacerbation.
  
  
  METHODS
  The study included 47 patients with COPD with mild to very severe airway obstruction and 40 age‑matched healthy subjects. C‑reactive protein levels and complete blood count were analyzed and compared in patients during the stable period and during exacerbation of COPD.
  
  
  RESULTS
  MPV values were 9.3 ±1.4 and 8.6 ±1.0 fl during stable period and during acute exacerbation, respectively. Mean MPV values in the control group were 9.3 ±0.8 fl. MPV values were significantly   lower in patients during acute exacerbation than in those during the stable period of COPD and in control subjects (both, P <0.001).
  
  
  CONCLUSIONS
  The results suggest that assessment of MPV in COPD exacerbation may indicate systemic inflammation. Thus, MPV may be used as a negative acute‑phase reactant in COPD exacerbation.
authors.affiliation: Afyon Kocatepe University, Faculty of Medicine, Department of Pulmonary Diseases, Afyon, Turkey. sevincsarinc@gmail.com
authors.forename: Sevinc S
authors.initials: SS
authors.lastname: Ulasli
authors.forename: Berna A
authors.initials: BA
authors.lastname: Ozyurek
authors.forename: Eylul B
authors.initials: EB
authors.lastname: Yilmaz
authors.forename: Gaye
authors.initials: G
authors.lastname: Ulubay
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D001792:Blood Platelets; D001810:Blood Volume; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein