title: Refined identification of neutralization-resistant HIV-1 CRF02_AG viruses.
abstract: We studied neutralization of CRF02_AG HIV-1-infected plasma samples. In contrast to previous reports, these samples neutralized CRF02_AG viruses better than other viruses. This included six of eight CRF02_AG viruses previously designated resistant (tier 2/3 or 3). Only viruses 253-11 and 278-50 remained highly resistant, but they were sensitive to membrane-proximal external region (MPER)-specific monoclonal antibodies, suggesting neutralization targets for even these viruses. We propose using high-neutralizing-within-subtype samples for evaluation of neutralization resistance of viruses.
authors.affiliation: International Centre for Genetic Engineering and Biotechnology, Cape Town.
authors.forename: Rajesh Abraham
authors.initials: RA
authors.lastname: Jacob
authors.forename: Fatima
authors.initials: F
authors.lastname: Abrahams
authors.forename: Marcel
authors.initials: M
authors.lastname: Tongo
authors.forename: Michael
authors.initials: M
authors.lastname: Schomaker
authors.forename: Paul
authors.initials: P
authors.lastname: Roux
authors.forename: Eitel
authors.initials: E
authors.lastname: Mpoudi Ngole
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Burgers
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Dorfman
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D057134:Antibodies, Neutralizing / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D009500:Neutralization Tests
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D015488:HIV Antigens