title: Treatment of combined endodontic-periodontic lesions using guided tissue regeneration: clinical case and histology.
abstract: The aim of this case report is to histologically evaluate periapical healing after combined endodontic-periodontic treatment. A maxillary left central incisor was treated with conventional endodontic therapy, followed by periodontal surgery. The facial bony defect was filled with a mixture of autologous bone and Bio-Oss. A resorbable membrane was used. Histology showed the presence of new cementum, ligament, and bone around the apex of the treated tooth. This finding was clinically associated with minimal residual probing depth and maximum attachment gain. This histologic report demonstrates the possibility of true regeneration in a case of severe periodontal attachment loss resulting from an endodontic-periodontic lesion.
authors.affiliation: carlo@studioghezzi.info
authors.forename: Carlo
authors.initials: C
authors.lastname: Ghezzi
authors.forename: Mauro
authors.initials: M
authors.lastname: Virzì
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: Alessandro
authors.initials: A
authors.lastname: Broccaioli
authors.forename: Massimo
authors.initials: M
authors.lastname: Simion
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use; D003094:Collagen; D003739:Dental Cementum / Q000473:pathology; D003788:Dental Pulp Diseases / Q000628:therapy*; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007180:Incisor / Q000473:pathology; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D017622:Periodontal Attachment Loss / Q000601:surgery; D010510:Periodontal Diseases / Q000601:surgery*; D010513:Periodontal Ligament / Q000473:pathology; D010514:Periodontal Pocket / Q000601:surgery; D012390:Root Canal Therapy / Q000379:methods; D019227:Tooth Apex / Q000473:pathology; D019553:Tooth, Nonvital / Q000628:therapy; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen