title: Outbreak of carbapenem-resistant Providencia stuartii in an intensive care unit.
abstract: Outbreaks by carbapenem-resistant Providencia stuartii (CRPS) are rarely described. Clinical characteristics of patients with CRPS in an intensive care unit and resistance mechanisms were investigated. Carbapenemase production and/or outer membrane alterations were not detected; only CTX-M-2 and AmpC hyperproduction were noted. The outbreak was ultimately controlled in a 3-month period.
authors.affiliation: Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Brazil. azavascki@hcpa.ufrgs.br
authors.forename: Alexandre P
authors.initials: AP
authors.lastname: Zavascki
authors.forename: Cecília G
authors.initials: CG
authors.lastname: Carvalhaes
authors.forename: Geórgia L
authors.initials: GL
authors.lastname: da Silva
authors.forename: Sílvia Pedroso
authors.initials: SP
authors.lastname: Tavares Soares
authors.forename: Luciana R
authors.initials: LR
authors.lastname: de Alcântara
authors.forename: Laura S
authors.initials: LS
authors.lastname: Elias
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sandri
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001938:Brazil; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D004196:Disease Outbreaks / Q000517:prevention & control; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D017053:Infection Control; D007362:Intensive Care Units; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011532:Providencia / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015415:Biomarkers; D015780:Carbapenems; C071167:beta-lactamase CTX-2; C048795:AmpC beta-lactamases; D001618:beta-Lactamases