title: Protein-carbon nanotube sensors: single platform integrated micro clinical lab for monitoring blood analytes.
abstract: Design of a unique, single-platform, integrated, multichannel sensor based on carbon nanotube (CNT)-protein adducts specific to each one of the major analytes of blood, glucose, cholesterol, triglyceride, and Hb1AC is presented. The concept underlying the sensor, amperometric detection, is applicable to various disease-monitoring strategies. There is an urgent need to enhance the sensitivity of glucometers to <5% level instead of greater than the present 15% standard in these detectors. CNTs enhance the signals derived from the interaction of the enzymes with the different analytes in blood. Fabricated sensors using the new methodology is a point-of-care device that is targeted for home, clinical, and emergency use and can be redesigned for continuous monitoring for critical care patients.
authors.affiliation: Newton-Wellesley Hospital/Partners Healthcare System, Newton, Massachusetts, USA.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Viswanathan
authors.forename: Pingzuo
authors.initials: P
authors.lastname: Li
authors.forename: Wonbong
authors.initials: W
authors.lastname: Choi
authors.forename: Slawomir
authors.initials: S
authors.lastname: Filipek
authors.forename: T A
authors.initials: TA
authors.lastname: Balasubramaniam
authors.forename: V
authors.initials: V
authors.lastname: Renugopalakrishnan
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis / Q000737:chemistry; D015374:Biosensing Techniques; D001774:Blood Chemical Analysis / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D002789:Cholesterol Oxidase / Q000096:biosynthesis / Q000737:chemistry; D005949:Glucose Oxidase / Q000096:biosynthesis / Q000737:chemistry; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D055767:Immobilized Proteins / Q000096:biosynthesis / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D008049:Lipase / Q000096:biosynthesis / Q000737:chemistry; D044085:Microfluidics; D008958:Models, Molecular; D037742:Nanotubes, Carbon; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D002787:Sterol Esterase / Q000096:biosynthesis / Q000737:chemistry; D013499:Surface Properties; D014280:Triglycerides / Q000097:blood
chemical_list: D000594:Amino Acid Oxidoreductases; D001786:Blood Glucose; D002784:Cholesterol; D002789:Cholesterol Oxidase; D005949:Glucose Oxidase; D006442:Glycated Hemoglobin; D055767:Immobilized Proteins; D008049:Lipase; D037742:Nanotubes, Carbon; D011994:Recombinant Proteins; D002787:Sterol Esterase; D014280:Triglycerides; C517652:hemoglobin A1c protein, human