title: The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Chhun
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rizzo-Padoin
authors.forename: Guy
authors.initials: G
authors.lastname: Simoneau
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.forename: Jean François
authors.initials: JF
authors.lastname: Bergmann
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mouly
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics* / Q000378:metabolism; D001944:Breath Tests; D065731:Cytochrome P-450 CYP2C19; D065729:Cytochrome P-450 CYP2C9; D051544:Cytochrome P-450 CYP3A / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D004917:Erythromycin / Q000031:analogs & derivatives / Q000032:analysis / Q000493:pharmacokinetics; D005602:France; D005787:Gene Frequency; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D011110:Polymorphism, Genetic; D011849:Radioactive Tracers; D055815:Young Adult
chemical_list: C481478:(N-methyl) erythromycin; C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000927:Anticonvulsants; D011849:Radioactive Tracers; D010672:Phenytoin; D004917:Erythromycin; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human