title: A convenient access to γ-lactones from O-allyl-α-bromoesters using a one-pot ionic-radical-ionic sequence.
abstract: Cognac in the jar! An efficient one-pot sequence for the preparation of γ-lactones is described. Following reduction of α-bromo ester precursors with DIBAL-H and radical cyclization of the resulting O-aluminum acetals, a preparative in-situ Oppenauer-type oxidation of the cyclic O-aluminum acetal using simple aldehydes or ketones gives access to γ-lactones in high yields.
authors.affiliation: Université de Nantes, Laboratoire CEISAM, UMR 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208-44322, Nantes Cedex 3, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Bénéteau
authors.forename: Jacques
authors.initials: J
authors.lastname: Lebreton
authors.forename: Fabrice
authors.initials: F
authors.lastname: Dénès