title: A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster.
abstract: Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Debashish U
authors.initials: DU
authors.lastname: Menon
authors.forename: Victoria H
authors.initials: VH
authors.lastname: Meller
mesh_terms: D000818:Animals; D004303:Dosage Compensation, Genetic / Q000235:genetics*; D029721:Drosophila Proteins / Q000172:deficiency / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D055785:Gene Knockdown Techniques; D008297:Male; D009154:Mutation; D034741:RNA, Small Interfering / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics; D014960:X Chromosome / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; C092595:Pabp2 protein, Drosophila; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C454144:roX1 protein, Drosophila