title: The role of hypoxia-inducible factor 1 in atherosclerosis.
abstract: Atherosclerosis is by far the most frequent underlying cause of coronary artery disease, carotid artery disease and peripheral arterial disease, and is associated with high morbidity and mortality. Hypoxic areas are known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages, increased local inflammation and angiogenesis. The key regulator of hypoxia, hypoxia-inducible factor 1 (HIF-1), plays a key role in the progression of atherosclerosis by initiating and promoting the formation of foam cells, endothelial cell dysfunction, apoptosis, increasing inflammation and angiogenesis. The objective of this review is to summarise the pathological role of HIF-1 in the progression of atherosclerosis.
authors.affiliation: Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Linggen
authors.initials: L
authors.lastname: Gao
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Fan
mesh_terms: D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000209:etiology* / Q000473:pathology; D015687:Cell Hypoxia / Q000502:physiology; D018450:Disease Progression; D042783:Endothelial Cells / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D007962:Leukocytes / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000473:pathology
chemical_list: D051793:Hypoxia-Inducible Factor 1