title: Cytochrome P450 2C19 Polymorphism in Iranian Patients with Coronary Artery Disease.
abstract: BACKGROUND
  The polymorphisms of cytochrome P450 2C19 (CYP2C19) gene are major prognostic factors for the response to clopidogrel therapy in patients with coronary artery diseases (CAD). The CYP2C19*2 is the most important allele responsible for resistance to clopidogrel therapy. This study examined CYP2C19 gene polymorphism (CYP2C19*1 and *2) in Iranian patients.
  
  
  METHODS
  This cross-sectional study was performed on 43 Iranian patients with CAD who underwent percutaneous coronary intervention (PCI) and received drug-eluted stents (DES). CYP2C19 polymorphisms were assessed using real time PCR and frequency of CYP2C19*1 and CYP2C19*2 were determined, and then homo- or heterozygous state of genes was detected by Melt Curve Analysis method.
  
  
  RESULTS
  Forty three patients (mean age = 58.8 ± 10.0 years, 79.1% male) participated in this study. CYP2C19*1/CYP2C19*1 genotype was observed in 31 (72.1%) of participates, CYP2C19*1/CYP2C19*2 genotype in 10 (23.3%), and CYP2C19*2/CYP2C19*2 genotype in 2 patients (4.7%). The frequency of CYP2C19*2 allele in the sample was 27.9%.
  
  
  CONCLUSIONS
  This study demonstrated a high prevalence of CYP2C19*2 gene polymorphism in Iranian patients. Further studies with larger samples or longitudinal are required to determine the effects of this polymorphism on the prognosis of CAD patients in our population.
authors.affiliation: MD, Fellowship of Cardiology, Department of Cardiology, Isfahan Cardiovascular Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Akhlaghi
authors.forename: Shahin
authors.initials: S
authors.lastname: Shirani
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Ziaie
authors.forename: Omid
authors.initials: O
authors.lastname: Pirhaji
authors.forename: Majid
authors.initials: M
authors.lastname: Yaran
authors.forename: Golnoosh
authors.initials: G
authors.lastname: Shahverdi
authors.forename: Nizal
authors.initials: N
authors.lastname: Sarrafzadegan
authors.forename: Alireza
authors.initials: A
authors.lastname: Khosravi
authors.forename: Elham
authors.initials: E
authors.lastname: Khosravi