title: Elementary steps in T cell receptor triggering.
abstract: The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggering, which likely reflect the uniquely demanding role of the TCR in recognizing diverse antigenic ligands. In this perspective, I propose that breaking down the process of TCR triggering into tractable elementary steps may be a useful approach in building mechanistic TCR triggering models. Once these elementary steps are understood, they can be recombined to build a unified model of TCR triggering.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford Oxford, UK. omer.dushek@path.ox.ac.uk
authors.forename: Omer
authors.initials: O
authors.lastname: Dushek