title: Effects of posterior capsular opacification on the evaluation of retinal nerve fiber layer as measured by Stratus optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the effects of posterior capsular opacification (PCO) and Nd:YAG laser capsulotomy on the evaluation of peripapillary retinal nerve fibre layer (RNFL) as measured by Stratus (Carl Zeiss Meditec, Dublin, CA) optical coherence tomography (OCT).
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  We studied 98 eyes of 89 patients experiencing PCO.
  
  
  METHODS
  We performed a complete ophthalmologic examination and evaluation of RNFL as measured by Stratus OCT before and after Nd:YAG capsulotomy. The patients were classified on the basis of PCO score or signal strength (SS) obtained by prelaser OCT scans.
  
  
  RESULTS
  The preoperative and postoperative peripapillary RNFL thicknesses were 90.24 ± 15.9 μm and 98.27 ± 14.1 μm, respectively (p < 0.001). The mean preoperative SSs were 5.4 ± 1.6, and they improved to 9.5 ± 0.5 postoperatively (p < 0.001). Prelaser and postlaser RNFL thicknesses differed significantly in eyes with preoperative SSs less than 7 (p < 0.05). Also, in patients with preoperative PCO grades higher than 2, there were significant increases in RNFL thickness after laser capsulotomy (p < 0.05).
  
  
  CONCLUSIONS
  RNFL thickness measured by the Stratus OCT is affected by PCO. RFNL thickness may be underestimated in eyes with preoperative PCO grades higher than 2 and in eyes with preoperative SSs lower than 7.
authors.affiliation: Department of Ophthalmology, Kanuni Sultan Suleyman Eye Research and Education Hospital, Istanbul, Turkey. dr.necipkara@gmail.com
authors.forename: Necip
authors.initials: N
authors.lastname: Kara
authors.forename: Hasan
authors.initials: H
authors.lastname: Altinkaynak
authors.forename: Kemal
authors.initials: K
authors.lastname: Yuksel
authors.forename: Tugba
authors.initials: T
authors.lastname: Kurt
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
mesh_terms: D058442:Capsule Opacification / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity