title: Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors.
abstract: Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged with photodynamic therapy (PDT)-induced tumor lysates, which contain the heat shock protein (HSP) 70. PDT tumor lysate-pulsed DC (PDT-DC) inhibited the growth of mammary EMT6 tumors to a greater extent than freeze/thawed tumor lysate-pulsed DC (FT-DC) or PDT tumor lysates. PDT-DC also showed significant anti-tumor effects against fully-established (i.e., late-stage) solid tumors. Taken together, these results suggest that PDT-DC vaccination is more effective than conventional DC therapy for the treatment of cancers.
authors.affiliation: Department of Applied Bioscience, Laboratory for Immune Cell-Based Therapy, CHA University, Gyeonggi-do 463-836, Republic of Korea.
authors.forename: Nam-Chul
authors.initials: NC
authors.lastname: Jung
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kang
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jie-Young
authors.initials: JY
authors.lastname: Song
authors.forename: Han Geuk
authors.initials: HG
authors.lastname: Seo
authors.forename: Yong-Soo
authors.initials: YS
authors.lastname: Bae
authors.forename: Dae-Seog
authors.initials: DS
authors.lastname: Lim
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005615:Freezing; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D007167:Immunotherapy / Q000379:methods*; D007376:Interleukin-2 / Q000378:metabolism; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*
chemical_list: D019496:Cancer Vaccines; D018840:HSP70 Heat-Shock Proteins; D007376:Interleukin-2