title: Immunologic basis of cardiovascular disease in HIV-infected adults.
abstract: Cardiovascular complications are more common in human immunodeficiency virus-infected individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the risk of cardiovascular complications, suggesting that viral replication directly or indirectly causes vascular disease. Long-term effective antiretroviral therapy does not fully restore vascular health, and treated adults continue to have higher-than-expected rates of disease progression. Although this excess risk during therapy is likely due to multiple factors, a growing body of evidence suggests that chronic inflammation, which persists during effective antiretroviral therapy, is directly and causally associated with vascular dysfunction and the accelerated development of atherosclerosis.
authors.affiliation: Division of Cardiology, Department of Medicine, San Francisco General Hospital, University of California-San Francisco, 995 Potrero Ave., San Francisco, CA 94110, USA.
authors.forename: Priscilla Y
authors.initials: PY
authors.lastname: Hsue
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Peter W
authors.initials: PW
authors.lastname: Hunt
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000150:complications* / Q000276:immunology*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology
chemical_list: D015415:Biomarkers