title: A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B).
abstract: Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5' non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.
authors.affiliation: Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, China.
authors.forename: Erxia
authors.initials: E
authors.lastname: Yang
authors.forename: Heng
authors.initials: H
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.forename: Lichun
authors.initials: L
authors.lastname: Wang
authors.forename: Pingfang
authors.initials: P
authors.lastname: Cui
authors.forename: Lixian
authors.initials: L
authors.lastname: Yang
authors.forename: Longding
authors.initials: L
authors.lastname: Liu
authors.forename: Chenghong
authors.initials: C
authors.lastname: Dong
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Dong
authors.forename: Congwen
authors.initials: C
authors.lastname: Shao
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Le
authors.initials: L
authors.lastname: Sun
authors.forename: Qihan
authors.initials: Q
authors.lastname: Li
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D002522:Chlorocebus aethiops; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D016679:Genome, Viral / Q000235:genetics; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000821:virology*; D006801:Humans; D051379:Mice; D010802:Phylogeny; D013045:Species Specificity; D014709:Vero Cells; D015678:Viral Structural Proteins / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D020121:5' Untranslated Regions; D015678:Viral Structural Proteins