title: Role of CREM in systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Immune complex, autoantibodies and autoreactive lymphocytes are involved in manifestations of SLE. Recently, investigations have indicated that expression of the transcription factor cAMP responsive element modulator (CREM) is abnormal in T cells and might play an important role in the pathogenesis of SLE. CREM has much influence on the promoters, such as IL-2, c-fos, TCR ζ, and SYK. Moreover, activity of CREM itself has been demonstrated, particularly with an auto-regulatory feedback mechanism. Therefore, we will discuss the association of CREM and SLE based on current knowledge to unravel the mechanism of CREM performance.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, PR China.
authors.forename: Wang-Dong
authors.initials: WD
authors.lastname: Xu
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000276:immunology / Q000378:metabolism; D051786:Cyclic AMP Response Element Modulator / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007378:Interleukins; D051786:Cyclic AMP Response Element Modulator; D000242:Cyclic AMP