title: Computer simulation of clinical electrophysiological study.
abstract: BACKGROUND
  Computer simulation is an important method for the basic researches of cardiac electrophysiology to prove the mechanisms and hypotheses of cardiac arrhythmias by reproducing body surface electrocardiograms. In this research, we extend the researches of heart models to the computer simulation of clinical electrophysiological study (EPS) as a clinical application of heart models.
  
  
  METHODS
  Through setting the standard EPS pacing protocols, including extrastimuli and incremental pacing in the heart models, we simulated the corresponding excitation propagations in the heart and the intracardiac electrograms that would be measured with catheter electrodes.
  
  
  RESULTS
  Examples of complicated cases observed during EPS are reproduced in this research, including the induction of a Wenckebach pattern, the induction and termination of supraventricular tachycardia due to the reentry loop of antidromic atrioventricular reentrant tachycardia for the Wolff-Parkinson-White (WPW) syndrome (Type A), and the localization of an accessory pathway for the WPW syndrome (Type A).
  
  
  CONCLUSIONS
  This study demonstrates an application of whole-heart modeling and computer simulation to clinical EPS.
authors.affiliation: Biomedical Information Technology Lab, the University of Aizu, Tsuruga, Ikki-machi, Aizu-Wakamatsu, Fukushima, Japan.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhu
authors.forename: Daming
authors.initials: D
authors.lastname: Wei
authors.forename: Osamu
authors.initials: O
authors.lastname: Okazaki
mesh_terms: D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular