title: Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes.
abstract: A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.
authors.affiliation: Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206-La Laguna, Tenerife, Spain.
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Saavedra
authors.forename: Alicia
authors.initials: A
authors.lastname: Boto
authors.forename: Rosendo
authors.initials: R
authors.lastname: Hernández
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D000596:Amino Acids; D010455:Peptides