title: Patient-specific simulation of a stentless aortic valve implant: the impact of fibres on leaflet performance.
abstract: In some cases of aortic valve leaflet disease, the implant of a stentless biological prosthesis represents an excellent option for aortic valve replacement (AVR). In particular, if compared with the implant of mechanical valves, it provides a more physiological haemodynamic performance and a reduced thrombogeneticity, avoiding the use of anticoagulants. The clinical outcomes of AVR are strongly dependent on an appropriate choice of both prosthesis size and replacement technique, which is, at present, strictly related to surgeon's experience and skill. This represents the motivation for patient-specific finite element analysis able to virtually reproduce stentless valve implantation. With the aim of performing reliable patient-specific simulations, we remark that, on the one hand, it is not well established in the literature whether bioprosthetic leaflet tissue is isotropic or anisotropic; on the other hand, it is of fundamental importance to incorporate an accurate material model to realistically predict post-operative performance. Within this framework, using a novel computational methodology to simulate stentless valve implantation, we test the impact of using different material models on both the stress pattern and post-operative coaptation parameters (i.e. coaptation area, length and height). As expected, the simulation results suggest that the material properties of the valve leaflets affect significantly the post-operative prosthesis performance.
authors.affiliation: a Dipartimento di Ingegneria Civile e Architettura (DICAr) , Università degli Studi di Pavia , Via Ferrata 1, 27100 , Pavia , Italy.
authors.forename: F
authors.initials: F
authors.lastname: Auricchio
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: A
authors.initials: A
authors.lastname: Ferrara
authors.forename: S
authors.initials: S
authors.lastname: Morganti
authors.forename: A
authors.initials: A
authors.lastname: Reali
mesh_terms: D001021:Aortic Valve / Q000000981:diagnostic imaging; D020342:Finite Element Analysis; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing; D008953:Models, Anatomic; D011859:Radiography; D013314:Stress, Mechanical