title: Synthesis of acridines and persubstituted phenols from cyclobutenones and active methylene ketones.
abstract: A new benzannulation strategy that proceeds via a regiospecific [4 + 2] cycloaddition of readily available cyclobutenones and active methylene ketones has been developed. On the basis of this strategy, persubstituted phenols/anilines with up to six different functional groups on the benzene ring were synthesized in a single step. In addition, a series of acridine derivatives were prepared in excellent yield from persubstituted phenols/anilines.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun, 130024, PR China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Han
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Zhao
authors.forename: Jia
authors.initials: J
authors.lastname: Meng
authors.forename: Chuan-Qing
authors.initials: CQ
authors.lastname: Ren
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D003503:Cyclobutanes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000166:Acridines; D003503:Cyclobutanes; D007659:Ketones; D010636:Phenols; C553737:cyclobutenone; D001554:Benzene