title: Association between serum homocysteine concentration with coronary artery disease in Iranian patients.
abstract: BACKGROUND
  The role of novel biomarkers like homocystein as a risk factor of coronary artery disease (CAD) is being increasingly recognized. Since there is a marked geographical variation in plasma homocystein concentration and because of importance of hyperhomocysteinemia as a CAD risk factor and due to the paucity of studies in Iran evaluating this risk factor in our population, we evaluated the association between plasma total homocysteine (tHcy) concentration and CAD risk in Iranian population.
  
  
  METHODS
  In a case-control study, we compared the level of tHcy of forty five patients of angiographically proven CAD with forty five subjects without CAD as control group matched for age and gender. The patients with diabetes, hypertension, thyroid dysfunction, chronic renal failure, hyperlipidemia and obesity and other conventional CAD risk factors were excluded from the study. Plasma tHcy was measured using immunoturbidimetry. The results were compared between groups using student t test.
  
  
  RESULTS
  CAD patients had significantly higher mean plasma tHcy than control group (17.1±5.3 versus 14.2±3.8, P= 0.004).
  
  
  CONCLUSIONS
  This study denoted that high plasma homocysteine concentration was associated to CAD risk in Iranian people.
authors.affiliation: Assistant Professor, Department of Cardiology, School of Medicine, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mirdamadi
authors.forename: Hamid
authors.initials: H
authors.lastname: Farzamnia
authors.forename: Pooyan
authors.initials: P
authors.lastname: Varzandeh
authors.forename: Naser
authors.initials: N
authors.lastname: Almasi
authors.forename: Mahfar
authors.initials: M
authors.lastname: Arasteh