title: [Study on metabolites of ferulic acid and gallic acid compatible with danggui and chishao in rat plasma and urine].
abstract: OBJECTIVE
  To study the major metabolites of ferulic acid and gallic acid compatible with Danggui Chishaoyao in rat plasma and urine.
  
  
  METHODS
  The metabolites of ferulic acid and gallic acid in rat plasma and urine were analyzed after oral administration of compatible Danggui Chishaoyao using UPLC-Q-TOF-MS.
  
  
  RESULTS
  On the basis of the mass information, it was inferred that in vivo metabolites of ferulic acid were be in the form of methylation products, sulfate conjugation products and glucuronidation conjugation products and so on; meanwhile, gallic acid was mainly transformed into eduction products and methylation products.
  
  
  CONCLUSIONS
  There are kinds of phase I and phase II metabolites of ferulic acid and gallic acid in rat plasma and urine, which provide a basis for its efficacious materials and action mechanism.
authors.affiliation: Jiangsu Key Laboratory for Traditonal Chinese Medicina Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Ding
authors.forename: Dawei
authors.initials: D
authors.lastname: Qian
authors.forename: Jin'ao
authors.initials: J
authors.lastname: Duan
authors.forename: Erxin
authors.initials: E
authors.lastname: Shang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
authors.forename: Yefei
authors.initials: Y
authors.lastname: Qian
authors.forename: Niancui
authors.initials: N
authors.lastname: Luo
mesh_terms: D000818:Animals; D003373:Coumaric Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000378:metabolism*; D005707:Gallic Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D041743:Herb-Drug Interactions; D008297:Male; D055442:Metabolome; D051381:Rats; D017207:Rats, Sprague-Dawley; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; C531150:danggui-shaoyao-san; D005707:Gallic Acid; C004999:ferulic acid