title: Green tea for ovarian cancer prevention and treatment: a systematic review of the in vitro, in vivo and epidemiological studies.
abstract: OBJECTIVE
  This systematic review was conducted to examine the effects of green tea or green tea components on the prevention and progression of epithelial ovarian cancer.
  
  
  METHODS
  Using Medline, EMBASE and SciVerse (last researched: July 2011), we retrieved 22 articles including 5 epidemiological studies.
  
  
  RESULTS
  In epithelial ovarian cancer cell lines, green tea and green tea components have been shown to downregulate the expression of proteins involved in inflammation, cell signalization, cell motility and angiogenesis. Green tea and green tea components would induce apoptosis and could potentiate the effects of cisplatin, a chemotherapeutic agent. In human observational studies, significant associations between green tea intake and both decreased ovarian cancer occurrence and better prognosis were reported.
  
  
  CONCLUSIONS
  Available literature suggests potential molecular targets for green tea in ovarian cancer treatment and also provides data supporting the clinical evaluation of the role of green tea or green tea components in ovarian cancer prevention and treatment.
authors.affiliation: Laval University Cancer Research Center, Hôtel-Dieu-de-Québec, University Hospital Center (CHUQ), 11 Côte du Palais, Québec, Québec, Canada. dtrudel@uhnres.utoronto.ca
authors.forename: Dominique
authors.initials: D
authors.lastname: Trudel
authors.forename: David P
authors.initials: DP
authors.lastname: Labbé
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bairati
authors.forename: Vincent
authors.initials: V
authors.lastname: Fradet
authors.forename: Laurent
authors.initials: L
authors.lastname: Bazinet
authors.forename: Bernard
authors.initials: B
authors.lastname: Têtu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D000077216:Carcinoma, Ovarian Epithelial; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D006801:Humans; D015994:Incidence; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism / Q000517:prevention & control*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism / Q000517:prevention & control*; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013662:Tea
chemical_list: D020011:Protective Agents; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate