title: Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis.
abstract: The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Berberine, given orally at 40, 20, 10 mg/kg for 10 days, ameliorated all the supposed inflammatory symptoms of the induced colitis, such as body weightloss, blood hemoglobin reduction, high myeloperoxidase levels, and malondialdehyde content-inflamed mucosa. Furthermore, the cytokine production of splenic lymphocytes was analyzed. The results showed the IFN-γ and IL-12 were increased, but IL-4 and IL-10 were decreased in DSS-induced colitis,when those were compared with the normal control. But the administration of berberine to DSS-induced colitis mice showed lower production of IFN-γ and IL-12 and higher production of IL-4 and IL-10 than the DSS-induced colitis mice. The results suggest that the protective effects of berberine against the DSS-induced colitis may be associated with the regulation of cytokine production.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, P. R. China. hongtie@jlu.edu.cn
authors.forename: Tie
authors.initials: T
authors.lastname: Hong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Chuan-Feng
authors.initials: CF
authors.lastname: Lv
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D003092:Colitis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000276:immunology; D016207:Cytokines / Q000097:blood / Q000276:immunology; D016264:Dextran Sulfate / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D001599:Berberine; D016264:Dextran Sulfate