title: The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism.
abstract: BACKGROUND
  Hyperthyroidism is associated with unpleasant symptoms and hypertension due to increased adrenergic tone. Therefore, beta-blockers are often used in hyperthyroid patients. While some beta-blockers (such as propronolol and metoprolol) may have unwanted effects on lipid profile, carvedilol, a new alpha- and beta-blocker, has been suggested to have some metabolic advantages with respect to lipid profiles in hypertensive patients. However, this has not been shown in hyperthyroid patients.
  
  
  OBJECTIVE
  We aimed to compare the effects of two beta-blockers (metoprolol and carvedilol) on the lipid profiles of hyperthyroid patients with hypertension.
  
  
  METHODS
  Thirty patients with hyperthyroidism and hypertension were randomly assigned to receive either carvedilol (n = 15) or metoprolol (n = 15). Thyroid-stimulating hormone (TSH), free T3, free T4, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and total cholesterol levels were measured before and following 3 months of treatment.
  
  
  RESULTS
  Systolic and diastolic blood pressure, heart rate, TSH, and free T4 improved significantly in both treatment groups. There were no statistically significant changes in the lipid parameters in either of the two treatment groups; however, triglyceride levels slightly decreased with carvedilol treatment. There were also no differences between the two groups in terms of the typical symptoms of hyperthyroidism.
  
  
  CONCLUSIONS
  Carvedilol might be a preferred agent to treat hyperthyroid patients who have hypertension and dyslipidemia. This is likely due to the possible beneficial effect of carvedilol on lipid parameters, especially on triglyceride levels.
authors.affiliation: Department of Internal Medicine, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Ozbilen
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Eren
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Turan
authors.forename: Tevfik
authors.initials: T
authors.lastname: Sabuncu
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006980:Hyperthyroidism / Q000150:complications*; D008055:Lipids / Q000097:blood*; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D008055:Lipids; D011412:Propanolamines; D000077261:Carvedilol; D013972:Thyrotropin; D008790:Metoprolol; D013974:Thyroxine