title: Use of serial measurements of peritoneal fluid lactate concentration to identify strangulating intestinal lesions in referred horses with signs of colic.
abstract: OBJECTIVE
  To determine the value of serial measurements of peritoneal fluid lactate concentration (PFL) for detecting strangulating intestinal lesions (SLs) in referred horses with signs of colic.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  94 horses with signs of colic.
  
  
  METHODS
  Medical records of horses evaluated between September 2006 and February 2010 because of signs of colic were reviewed. All included horses had ≥ 2 peritoneal fluid samples collected, including one at admission and another within 1 to 6 hours after admission. Of the 94 horses, 26 were assigned to the SL group on the basis of findings at surgery or necropsy and 68 were assigned to the nonstrangulating intestinal lesion group because their signs of colic resolved with medical management. Peritoneal fluid lactate concentration was measured by use of a handheld lactate monitor. Data were analyzed by use of univariable and multivariable logistic regression analysis.
  
  
  RESULTS
  PFL at admission > 4 mmol/L, an increase in PFL over time, and especially an increase in PFL over time in horses with a PFL < 4 mmol/L at admission (OR, 62; sensitivity, 95%; specificity, 77%) were significant predictors of horses with an SL.
  
  
  CONCLUSIONS
  Serially determined PFL was a strong predictor for differentiating horses with SLs from horses with nonstrangulating intestinal lesions. Given the high OR, sensitivity, and specificity of these tests, serially determined PFL may have potential as a screening test for identifying horses with SLs. Further evaluation of the clinical value of PFL for predicting SLs in a prospective, multicenter study is warranted.
authors.affiliation: Equine Medical Center of Ocala, 7107 W Hwy 326, Ocala, FL 34482, USA. jpeloso@emcocala.com
authors.forename: John G
authors.initials: JG
authors.lastname: Peloso
authors.forename: Noah D
authors.initials: ND
authors.lastname: Cohen
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D003085:Colic / Q000378:metabolism / Q000662:veterinary*; D003251:Constriction, Pathologic / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000378:metabolism*; D006736:Horses; D007415:Intestinal Obstruction / Q000378:metabolism / Q000662:veterinary*; D019344:Lactic Acid / Q000032:analysis*; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D019344:Lactic Acid