title: Highly efficient enantioselective three-component synthesis of 2-amino-4H-chromenes catalysed by chiral tertiary amine-thioureas.
abstract: A three-component cascade reaction of salicylaldehyde, malononitrile/cyanoacetate and nitromethane catalysed by chiral tertiary amino-thioureas was developed, which leads to the production of highly functionalized 2-amino-4H-chromenes in good yields with good to excellent enantioselectivities.
authors.affiliation: Anhui Key Laboratory of Functional Molecular Solids, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China. gshyang@mail.ahnu.edu.cn
authors.forename: Gaosheng
authors.initials: G
authors.lastname: Yang
authors.forename: Chongrong
authors.initials: C
authors.lastname: Luo
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Mu
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D009595:Nitroparaffins / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D001578:Benzopyrans; D009570:Nitriles; D009595:Nitroparaffins; C013243:salicylaldehyde; C000945:dicyanmethane; D013890:Thiourea; D008697:Methane; C008640:nitromethane