title: Individual and concomitant effects of cardioprotective programs on cardiac apelinergic system and oxidative state in L-NAME-induced hypertension.
abstract: The effect of aerobic training and Ferula gummosa supplementation (90 mg/kg) on apelinergic system and markers of cardiac stress in hypertensive rats were studied. Chronically administered l-NAME resulted in an increased level of angiotensin-converting enzyme (ACE), malondialdehyde (MDA), and high-sensitive C-reactive protein (hs-CRP), and also reduced the levels of apelin, apelin and its receptor (APJ), and nitric oxide (NO) and the total antioxidant capacity (TAC), when compared with the control group. The combination of aerobic exercise and Ferula gummosa decreased MDA and hs-CRP and significantly increased cardiac apelinergic system, NO, and TAC, when compared with the control and the l-NAME groups. A rationale for an inhibitory role and a cardioprotective effect of aerobic exercise training in the attenuation of hypertension-induced cardiotoxicity was developed.
authors.affiliation: Department of Sport Physiology, College of Physical Education and Sport Science, Tarbiat Modarres University, Tehran, Iran.
authors.forename: Seeyed Ali Akbar
authors.initials: SA
authors.lastname: Mahmoody
authors.forename: Reza
authors.initials: R
authors.lastname: Gharakhanlou
authors.forename: Valiollah Dabidi
authors.initials: VD
authors.lastname: Roshan
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D000073861:Apelin; D000075244:Apelin Receptors; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D019587:Dietary Supplements; D005309:Ferula; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000073861:Apelin; D000075244:Apelin Receptors; C498579:Apln protein, rat; C491284:Aplnr protein, rat; D015415:Biomarkers; D002316:Cardiotonic Agents; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; D009569:Nitric Oxide; D008315:Malondialdehyde; D002097:C-Reactive Protein; D007703:Peptidyl-Dipeptidase A; D019331:NG-Nitroarginine Methyl Ester