title: Steam-dried ginseng berry fermented with Lactobacillus plantarum controls the increase of blood glucose and body weight in type 2 obese diabetic db/db mice.
abstract: This study examined whether steam-dried ginseng berries fermented with Lactobacillus plantarum (FSGB) could improve the indices of type 2 diabetes mellitus (T2DM) in obese db/db mice. FSGB was shown to have an effect on body weight and blood glucose/serum parameters when administered at a dose of 0.5 g/kg. In the intraperitoneal glucose tolerance test (IPGTT) and insulin tolerance test (ITT), FSGB was clearly shown to improve insulin tolerance and glucose tolerance. Moreover, FSGB was shown to enhance immune activities by increasing the immune cell population, and glucose transpoter 1 (GLUT1) mRNA expression in L6 cells was up-regulated, suggesting that FSGB can increase glucose transport activity in target cells. These results indicate that steam- and dry-processed ginseng berries fermented with L. plantarum can be used to effectively control blood sugar metabolism via improving insulin and glucose tolerance and body weight gain in db/db mice.
authors.affiliation: Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University, Gangwon 210-702, Republic of Korea.
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Hae Bok
authors.initials: HB
authors.lastname: Kim
authors.forename: Kyu Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Young Ri
authors.initials: YR
authors.lastname: Choi
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Il Shik
authors.initials: IS
authors.lastname: Shin
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Gyoung
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Joo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005285:Fermentation; D005638:Fruit / Q000737:chemistry / Q000382:microbiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000378:metabolism; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D005894:Panax / Q000737:chemistry* / Q000382:microbiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts