title: Meningitis due to ampicillin-and chloramphenicol-resistant Haemophilus influenzae type b in Canada. Case report and review.
abstract: The first report of a case of ampicillin- and chloramphenicol-resistant Haemophilus influenzae type b invasive infection in Canada is described in a four-month-old male with meningitis. He was treated with cefotaxime 200 mg/kg/day divided every 6 h and dexamethasone 0.6 mg/kg/day divided every 6 h, eventually recovering after a complicated course. Follow-up at 21 months showed mild to moderate global developmental delay. While chloramphenicol resistance is rare in North America, a case of meningitis initially unresponsive to ampicillin and chloramphenicol must be considered suspect for resistance. Third generation cephalosporins should be used for resistant cases.
authors.affiliation: Department of Pediatrics, Microbiology and Infectious Diseases, Alberta Children's Hospital, University of Calgary, Calgary, Alberta.
authors.forename: A
authors.initials: A
authors.lastname: Kabani
authors.forename: A
authors.initials: A
authors.lastname: Joffe
authors.forename: G
authors.initials: G
authors.lastname: Cadrain
authors.forename: T
authors.initials: T
authors.lastname: Jadavji