title: Miscarriage, and TNF-α and osteopontin relationship in women patients with Hashimoto's thyroiditis.
abstract: OBJECTIVE
  Infertility and reproductive impairment can be compromised by abnormalities in both endocrine and immune system. TNF-α promotes apoptotic cell death in fetal membrane tissues and pro-inflammatory, proapoptotic, and procoagulant properties of TNF-α probably contribute to widely accepted abortogenic profile of this cytokine. The aim of this study was to assess the alteration in the levels of TSH, FT3, FT4, TNF-α, osteopontin in pregnant and controls.
  
  
  METHODS
  Study subjects were 28 pregnant women, 28 non-pregnant women, and 28 healthy controls. All subjects underwent venous blood drawing for levels of TNF-α, osteopontin, and also hormonal assays including the levels of anti-TPO, anti-TG antibodies, TSH, FT3, FT4.
  
  
  RESULTS
  Both patient and control groups are similar in terms of age. Pregnancy age in conceived patients is 23.64 ± 2.040. No statistically meaningful relation was found in correlation analysis between TNF-α and osteopontin among the groups (p = 0.963). Anti-thyroglobuline antibody and anti-microsomal antibody levels were found to be higher in patients with non-pregnant patients with Hashimoto thyroiditis than the control group (p < 0.001). No statistically meaningful relation was found in terms of TNF-α (p = 0.66) and osteopontin serum levels (p = 0.50) in patient groups with or without miscarriage history.
  
  
  CONCLUSIONS
  In our study, no statistically meaningful relation was found in terms of TNF-α and osteopontin serum levels in patient groups with and without miscarriage history.
authors.affiliation: Department of Endocrinology and Metabolism, University of Katip Celebi, Izmir, Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Harman
authors.forename: Muammer
authors.initials: M
authors.lastname: Karadeniz
authors.forename: Cigir Biray
authors.initials: CB
authors.lastname: Avci
authors.forename: Ayhan
authors.initials: A
authors.lastname: Zengi
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdogan
authors.forename: Murat
authors.initials: M
authors.lastname: Yalcin
authors.forename: Sevki
authors.initials: S
authors.lastname: Cetinkalp
authors.forename: Ozgen
authors.initials: O
authors.lastname: Ahmet Gokhan
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gunduz
authors.forename: Fusun
authors.initials: F
authors.lastname: Saygili
authors.forename: Candeger
authors.initials: C
authors.lastname: Yilmaz
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D053495:Osteopontin / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology / Q000503:physiopathology*; D011446:Prospective Studies; D013961:Thyroid Gland / Q000276:immunology / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D014409:Tumor Necrosis Factor-alpha; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D053495:Osteopontin