title: Chronic rejection in a small bowel transplant with successful revision of the allograft by segmental resection: case report.
abstract: An 8-year-old girl was admitted for severe electrolyte imbalance and for hyponatremic seizure. In July 2005, at 3 years of age, she underwent isolated small-bowel transplantation of 100 cm ileum from her father. Her own bowel was only 50 cm of proximal jejunum which had been directly connected to the anus due to extended total aganglionosis. The graft was placed into the middle of her remaining bowel, using the splenic artery and vein as feeding vessels with saving of the spleen. Daclizumab induction and tacrolimus monotherapy were applied for immunosuppression. Two acute cellular rejection episodes, E on day 10 and 4 years after transplantation, were successfully treated with OKT-3 and recombinant antithymocyte globulin, respectively. However, because of intermittent bowel dysfunction, she was hospitalized several times for hydration and metabolic care. On admission, her abdomen was moderately distended, and a simple abdominal film showed a fixed dilated loop. Colonoscopy could not pass the narrowed lumen, with stiffness at the anastomosis between the graft and the distal bowel. Endoscopic biopsy at the entrance to the stricture showed a nonspecific inflammatory reaction with fibrosis. Similar findings on a gastrograffin enema suggested chronic rejection (CR). On laparotomy, an irregularly narrowed fibrotic loop was noticed at the distal part of the graft, proximal to the anastomosis. We performed a 20-cm segmental resection with an end-to-end anastomosis. Histopathologic findings showed CR with fibrosis and hyalinization of the entire bowel wall and vessel walls with mild cellular infiltrations. She recovered in 10 days. The graft may have been saved, but intermittent requirement of hydration over the following months suggested progressive graft dysfunction. A case of segmental involvement of CR with subsequent successful graft salvage by partial resection is rare in the literature.
authors.affiliation: Department of Surgery, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: D G
authors.initials: DG
authors.lastname: Kim
authors.forename: I S
authors.initials: IS
authors.lastname: Moon
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.forename: J I
authors.initials: JI
authors.lastname: Kim
authors.forename: S A
authors.initials: SA
authors.lastname: Im
authors.forename: E S
authors.initials: ES
authors.lastname: Jung
authors.forename: J M
authors.initials: JM
authors.lastname: Park
authors.forename: M D
authors.initials: MD
authors.lastname: Lee
mesh_terms: D001706:Biopsy; D002675:Child, Preschool; D002908:Chronic Disease; D005220:Fathers; D005260:Female; D005355:Fibrosis; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007082:Ileum / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007583:Jejunum / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D019520:Living Donors; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects*; D012086:Reoperation; D012778:Short Bowel Syndrome / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents