title: Synthesis, characterization and evaluation of mannich bases as potent antifungal and hydrogen peroxide scavenging agents.
abstract: In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tropicalis and Aspergillus niger and antioxidant activity. The structure of these compounds was confirmed by IR, 1H NMR and 13C NMR studies. Most of the compounds exhibited moderate to significant activities.
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozepur Road, Moga-142 001, India.
authors.forename: Manav
authors.initials: M
authors.lastname: Malhotra
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sharma
authors.forename: Mohit
authors.initials: M
authors.lastname: Sanduja
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kumar
authors.forename: Jainendra
authors.initials: J
authors.lastname: Jain
authors.forename: Aakash
authors.initials: A
authors.lastname: Deep
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D008352:Mannich Bases; D006861:Hydrogen Peroxide