title: Prognostic role of Helicobacter pylori infection in acute coronary syndrome: a prospective cohort study.
abstract: In a prospective cohort study, we evaluated the effect of Helicobacter pylori seropositivity on the risk of future adverse cardiovascular outcomes among patients with acute coronary syndrome (ACS). In 433 patients, IgA and IgG antibodies to H pylori, along with classic risk factors, including hypertension, diabetes, hyperlipidaemia, smoking and family history of coronary artery disease (CAD) were determined. Short and long-term follow-up information on adverse outcomes, defined as recurrence of unstable angina, myocardial infarction, coronary angioplasty, coronary artery bypass graft surgery, and sudden cardiac death was obtained. None of the classic CAD risk factors correlated with incidence of either short- or long-term outcomes. Seropositivity for H pylori was significantly associated with risk of short-term adverse outcomes, and independently predicted their incidence in multivariate regression (R = 3.05, p < 0.001). Results failed to show such an association between H pylori seropositivity and long-term adverse outcomes. H pylori infection may affect short-term prognosis in patients with ACS. Randomised trials are needed to evaluate the role of H pylori eradication in these patients.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Seman University of Medical Sciences, Semnan, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Eskandarian
authors.forename: R
authors.initials: R
authors.lastname: Ghorbani
authors.forename: M
authors.initials: M
authors.lastname: Shiyasi
authors.forename: B
authors.initials: B
authors.lastname: Momeni
authors.forename: K
authors.initials: K
authors.lastname: Hajifathalian
authors.forename: M
authors.initials: M
authors.lastname: Madani
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D015331:Cohort Studies; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G