title: Rhabdomyolysis and severe muscle weakness secondary to colistin therapy.
abstract: Rhabdomyolysis is a clinical condition that causes renal failure up to 40%. Rhabdomyolysis may be traumatic or nontraumatic. Colistin (polymyxin E) is an effective antibiotic. Nephrotoxicity is a frequently encountered side effect. The nephrotoxic effect of colistin is thought to be associated with increased membrane permeability, cell swelling and lysis, and the development of acute tubular necrosis. Here, we report a case of nontraumatic rhabdomyolysis associated with the use of colistin. There is only one report of rhabdomyolysis secondary to colistin in the literature, and there is no report of a case developing severe tetraparesis, as in our case.
authors.affiliation: Department of Nephrology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. gulsumozkan78@hotmail.com
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Özkan
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Ulusoy
authors.forename: Sibel
authors.initials: S
authors.lastname: Gazioğlu
authors.forename: Muammer
authors.initials: M
authors.lastname: Cansız
authors.forename: Kübra
authors.initials: K
authors.lastname: Kaynar
authors.forename: Derya
authors.initials: D
authors.lastname: Arı
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003091:Colistin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010291:Paresis / Q000139:chemically induced*; D012206:Rhabdomyolysis / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin