title: Late-onset temporal lobe epilepsy in a patient with juvenile myoclonic epilepsy.
abstract: We report a patient with longstanding, severe juvenile myoclonic epilepsy who subsequently developed features of temporal lobe epilepsy, which gradually became clinically dominant. Over the years, there was an electrographic evolution from the typical generalised epileptiform patterns, characteristic of juvenile myoclonic epilepsy, to the novel appearance of interictal temporal spikes immediately preceding bisynchronous discharges, and subsequently to temporal intermittent rhythmic delta activity and temporal lobe-onset seizures. In this rare case of coexistent primary generalised epilepsy and focal epilepsy, the epileptic networks of the two forms of epilepsy appear to overlap.
authors.affiliation: Department of Neurology, University of Washington, Seattle, Washington, USA. lie@uthscsa.edu
authors.forename: Octavian V
authors.initials: OV
authors.lastname: Lie
authors.forename: Mark D
authors.initials: MD
authors.lastname: Holmes
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D004351:Drug Resistance; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications* / Q000175:diagnosis; D009415:Nerve Net / Q000473:pathology; D012640:Seizures / Q000209:etiology; D013064:Speech Disorders / Q000209:etiology
chemical_list: D000927:Anticonvulsants