title: Plasma profiles of glucose, insulin and lipids in the male WBN/Kob-Lepr(fa) rat, a new model of type 2 diabetes with obesity.
abstract: Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr(fa) (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.
authors.affiliation: Department of Pharmacology, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kaji
authors.forename: Akira
authors.initials: A
authors.lastname: Okuno
authors.forename: Kanako
authors.initials: K
authors.lastname: Ohno-Ichiki
authors.forename: Hisako
authors.initials: H
authors.lastname: Oki
authors.forename: Haruya
authors.initials: H
authors.lastname: Ishizawa
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Shirai
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Asai
mesh_terms: D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004195:Disease Models, Animal; D007328:Insulin / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids