title: Efficacy of pectin solution for preventing gastro-esophageal reflux events in patients with percutaneous endoscopic gastrostomy.
abstract: The aim of this study was to determine the efficacy of pectin solution, which increases the viscosity of liquid nutrient, for prevention of gastro-esophageal reflux in comparison with half-solid nutrient. The subjects were 10 elderly patients undergoing percutaneous endoscopic gastrostomy feeding. Twenty-four-hour esophageal multichannel intraluminal impedance and pH testing was performed during intake of half-solid nutrient and a combination of pectin solution and liquid nutrient. During 4 h after delivery, there was no significant difference in the total number of gastro-esophageal reflux events between the feeding of the half-solid nutrient and the combination of pectin solution and liquid nutrient (5.7 ± 1.2 vs 5.3 ± 1.0/4 h). Acidic reflux after delivery of the half-solid nutrient was significantly more frequent than that after delivery of the combination of pectin solution and liquid nutrient (80.7% vs 60.4%, p = 0.018). The incidence of gastro-esophageal reflux reaching the upper portion of the esophagus tended to be higher during delivery of the half-solid nutrient than during delivery of the combination of pectin solution and liquid nutrient (47.4% vs 34.0%, p = 0.153). In conclusion, the usage of pectin solution combined with liquid nutrient is effective for preventing acidic gastro-esophageal reflux and gastro-esophageal reflux reaching the upper portion of the esophagus.
authors.affiliation: Department of Clinical Nursing, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan.
authors.forename: Kyoichi
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authors.lastname: Adachi
authors.forename: Kenji
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authors.lastname: Furuta
authors.forename: Masahito
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authors.lastname: Aimi
authors.forename: Kousuke
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authors.lastname: Fukazawa
authors.forename: Shino
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authors.lastname: Shimura
authors.forename: Shunji
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authors.lastname: Ohara
authors.forename: Shuji
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authors.lastname: Nakata
authors.forename: Yukiko
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authors.lastname: Inoue
authors.forename: Kanji
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authors.lastname: Ryuko
authors.forename: Junichi
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authors.lastname: Ishine
authors.forename: Kyoko
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authors.lastname: Katoh
authors.forename: Toshiaki
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authors.lastname: Hirata
authors.forename: Shuzo
authors.initials: S
authors.lastname: Ohhata
authors.forename: Setsushi
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authors.lastname: Katoh
authors.forename: Mika
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authors.lastname: Moriyama
authors.forename: Masuko
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authors.lastname: Sumikawa
authors.forename: Mari
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authors.lastname: Sanpei
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita