title: Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.
abstract: In Pseudomonas aeruginosa, the catabolite repression control (Crc) protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis. Crc bound to an extended imperfect recognition sequence that was interrupted by the AUG translation initiation codon.
authors.affiliation: School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, People’s Republic of China.
authors.forename: Jiaofang
authors.initials: J
authors.lastname: Huang
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sonnleitner
authors.forename: Bin
authors.initials: B
authors.lastname: Ren
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Xu
authors.forename: Dieter
authors.initials: D
authors.lastname: Haas
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D057465:Catabolite Repression; D018387:Codon, Initiator; D015964:Gene Expression Regulation, Bacterial; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D011710:Pyocyanine / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D019802:Succinic Acid / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D018387:Codon, Initiator; D012097:Repressor Proteins; C101896:crc protein, Pseudomonas; D011710:Pyocyanine; D019802:Succinic Acid; D008780:Methyltransferases; C439052:PhzM protein, Pseudomonas aeruginosa