title: MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.
abstract: BACKGROUND
  In carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes. MG98 was designed to inhibit DNA methyltransferases enzyme 1 production.
  
  
  METHODS
  This multicenter study explored two schedules of MG98 with Interferon-α-2β to identify schedule and dose for patients with metastatic RCC.
  
  
  RESULTS
  Doses of IFN 9 MIU/MG98 125 mg/m(2) for a continuous schedule and IFN 9 MIU/MG98 200 mg/m(2) for an intermittent schedule were considered the MTDs. Treatment resulted in one PR and eight SD.
  
  
  CONCLUSIONS
  MG98 combined with IFN was safe and resulted in clinical activity.
authors.affiliation: Department of Internal Medicine, The University of Texas Medical School/ Memorial Hermann Cancer Center, Houston, Texas 77030, USA. Robert.Amato@uth.tmc.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amato
authors.forename: Joe
authors.initials: J
authors.lastname: Stephenson
authors.forename: Sebastien
authors.initials: S
authors.lastname: Hotte
authors.forename: John
authors.initials: J
authors.lastname: Nemunaitis
authors.forename: Karl
authors.initials: K
authors.lastname: Bélanger
authors.forename: Gregory
authors.initials: G
authors.lastname: Reid
authors.forename: Robert E
authors.initials: RE
authors.lastname: Martell
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000401:mortality; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors*; D018572:Disease-Free Survival; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D009838:Oligodeoxyribonucleotides / Q000009:adverse effects / Q000627:therapeutic use*; D013873:Thionucleotides / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: C483603:MG 98 phosphorothioate antisense oligodeoxynucleotide; D009838:Oligodeoxyribonucleotides; D013873:Thionucleotides; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619380:DNMT1 protein, human