title: The role of the PGE2-aromatase pathway in obesity-associated breast inflammation.
abstract: Subbaramaiah and colleagues present the first evidence indicating that a cyclooxygenase-2-prostaglandin E(2)-aromatase pathway promotes obesity-associated inflammation in women's breast tissues. Their findings shed new light on obesity-associated inflammation in general and provide a rationale for developing effective chemopreventive and therapeutic strategies targeting this pathway for obese women with breast inflammation and patients with hormone-dependent breast cancer.
authors.affiliation: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Wang
authors.forename: Raymond N
authors.initials: RN
authors.lastname: DuBois
mesh_terms: D001141:Aromatase / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D042361:Mammary Glands, Human / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D001141:Aromatase; D051546:Cyclooxygenase 2; D015232:Dinoprostone