title: A case of Good syndrome with pulmonary lesions similar to diffuse panbronchiolitis.
abstract: We herein present a case of Good syndrome complicated by diffuse pulmonary lesions similar to diffuse panbronchiolitis (DPB). A 45-year-old Japanese man was referred to our department due to recurrent lower respiratory tract infections that had started and ameliorated nine months after thymectomy for pure red cell aplasia and myasthenia gravis. Diffuse centrilobular opacities on chest computed tomography and positivity for HLA-B54 were consistent with DPB. Additionally, hypogammaglobulinemia and a marked decrease of B-lymphocytes were observed, and therefore Good syndrome was considered. Combination therapy with azithromycin and clarithromycin alleviated the patient's respiratory symptoms and reduced the exacerbation of chronic bronchitis.
authors.affiliation: Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan. togoshi@med.uoeh-u.ac.jp
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ogoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yatera
authors.forename: Keishi
authors.initials: K
authors.lastname: Oda
authors.forename: Kentarou
authors.initials: K
authors.lastname: Akata
authors.forename: Kei
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kido
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kawanami
authors.forename: Chiharu
authors.initials: C
authors.lastname: Yoshii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D000361:Agammaglobulinemia / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D001988:Bronchiolitis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015235:HLA-B Antigens / Q000097:blood; D006192:Haemophilus Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013945:Thymoma / Q000097:blood / Q000150:complications / Q000175:diagnosis*
chemical_list: D015235:HLA-B Antigens; C113783:HLA-B54 antigen