title: The effects of ageing on proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.
abstract: Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.
authors.affiliation: University College London Institute for Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, United Kingdom.
authors.forename: Emma
authors.initials: E
authors.lastname: Fossett
authors.forename: Wasim S
authors.initials: WS
authors.lastname: Khan
authors.forename: Philip
authors.initials: P
authors.lastname: Pastides
authors.forename: Adetola B
authors.initials: AB
authors.lastname: Adesida
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism*; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers