title: An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts.
abstract: This study investigates the effect of well-defined poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) ABA linear block co-oligomers on the proliferation of human dermal fibroblasts. The co-oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic-lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co-oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down-regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures with highest efficiency to be determined. These results suggest the possible use of the PEG-PDMS-PEG block co-oligomers as an alternative to silicone gels for hypertrophic scar remediation.
authors.affiliation: Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, 60 Musk Avenue, Queensland, Australia.
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Farrugia
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Keddie
authors.forename: Graeme A
authors.initials: GA
authors.lastname: George
authors.forename: Emily C
authors.initials: EC
authors.lastname: Lynam
authors.forename: Michael A
authors.initials: MA
authors.lastname: Brook
authors.forename: Zee
authors.initials: Z
authors.lastname: Upton
authors.forename: Tim R
authors.initials: TR
authors.lastname: Dargaville
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D012833:Siloxanes / Q000737:chemistry / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects*
chemical_list: D012833:Siloxanes