title: Muscling in on PGC-1α for improved quality of life in ALS.
abstract: Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.
authors.affiliation: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA. johri.ashu@gmail.com
authors.forename: Ashu
authors.initials: A
authors.lastname: Johri
authors.forename: M Flint
authors.initials: MF
authors.lastname: Beal