title: Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry.
abstract: Based on the advantages of natural products in new anti-cancer drug development, we synthesized a series of novel benzopyran-4-one derivatives and evaluated their in vitro anti-cancer activities. The bioassays showed that the majority of the resultant compounds exerted anti-tumor effect against six human cancer cell lines to various extents, which supported the rationale of the design. Compound 5s exhibited highest potency of all the synthesized compounds.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, No 325, Guohe Road, Shanghai 200433, China.
authors.forename: Yikai
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Lv
authors.forename: Hanyu
authors.initials: H
authors.lastname: Zhong
authors.forename: Dongping
authors.initials: D
authors.lastname: Geng
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D057930:Click Chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; C058446:geiparvarin