title: Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum.
abstract: Two new epipolythiodioxopiperazines, named chetracins B and C (1 and 2), and five new diketopiperazines, named chetracin D (4) and oidioperazines A-D (5, 10, 12, and 13), were isolated from the fungus Oidiodendron truncatum GW3-13, along with six known compounds (3, 6, 7, 8, 9, and 11). Their structures were elucidated by extensive NMR, MS, and CD analyses, as well as chemical transformation. An in vitro MTT cytotoxicity assay revealed potent biological activity for 1 in the nanomolar range against a panel of five human cancer lines.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy,  Ocean University of China , Qingdao 266003, People's Republic of China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Li
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.forename: Yepeng
authors.initials: Y
authors.lastname: Luan
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
mesh_terms: D000864:Antarctic Regions; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D054659:Diketopiperazines; C574263:chetracin B; C574264:chetracin C