title: Semi-synthetic heparinoids.
abstract: New chemical-enzymatic technology based on the modification of the bacterial polysaccharide K5 from Escherichia coli leads to the synthesis of a number of heparin/heparan sulfate-like molecules with different biological activities. With this technology, two families of sulfated compounds were synthesized, which differ in their uronic acid content. The first group contains only glucuronic acid, whereas the second group contains about 50% iduronic acid following epimerization by immobilized recombinant C5 epimerase. This has led to the development of various anticoagulant and nonanticoagulant K5 derivatives endowed with different - and sometimes highly specific - antitumor, antiviral, and/or anti-inflammatory activities.
authors.affiliation: Glycores 2000 S.r.l., Milan, Italy. oreste@glycores.it
authors.forename: P
authors.initials: P
authors.lastname: Oreste
authors.forename: G
authors.initials: G
authors.lastname: Zoppetti
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006496:Heparinoids / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011134:Polysaccharides / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D006496:Heparinoids; D011134:Polysaccharides