title: Parallel synthesis of 2-substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides.
abstract: A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1-12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic amines 18{1-12} to afford the corresponding carboxamides 10 in good overall yields and in 80-100% purity.
authors.affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, P.O. Box 537, 1000 Ljubljana, Slovenia.
authors.forename: Bojana
authors.initials: B
authors.lastname: Crček
authors.forename: Jernej
authors.initials: J
authors.lastname: Baškovč
authors.forename: Uroš
authors.initials: U
authors.lastname: Grošelj
authors.forename: Drago
authors.initials: D
authors.lastname: Kočar
authors.forename: Georg
authors.initials: G
authors.lastname: Dahmann
authors.forename: Branko
authors.initials: B
authors.lastname: Stanovnik
authors.forename: Jurij
authors.initials: J
authors.lastname: Svete
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis*; D013386:Succinates / Q000737:chemistry
chemical_list: D000577:Amides; D000588:Amines; D002264:Carboxylic Acids; D011743:Pyrimidines; D013386:Succinates; C005229:itaconic acid