title: Plasma angiogenin and vascular endothelial growth factor a among hemodialysis patients.
abstract: BACKGROUND
  Angiogenesis plays a role in the pathogenesis of coronary heart disease (CHD) and diabetes mellitus (DM) pathology, and certain angiogenic factors are increased by inflammation. The aim of this study was to evaluate plasma angiogenin and vascular endothelial factor A (VEGFA) levels in hemodialysis patients, as well as the effect of CHD, DM, and inflammation on these markers.
  
  
  METHODS
  Sixty-six hemodialysis patients were enrolled in the study, of whom 22 (33.3%) suffered from CHD , 22 (33.3%) from DM, and 28 (42.4%) from inflammation. They were compared with 24 healthy volunteers. Plasma angiogenin and VEGFA were assessed by means of enzyme-linked immunosorbent assay, and serum C-reactive protein was measured with an immunoturbidimetric method. These markers were compared between hemodialysis patients with and without CHD, DM, and inflammation.
  
  
  RESULTS
  Compared to healthy volunteers, plasma angiogenin was significantly higher in hemodialysis patients (263.57 ± 65.95 ng/mL versus 499.15 ± 175.68 ng/mL; P < .001). Similarly, plasma VEGFA was markedly increased in hemodialysis patients (median, 60.50 pg/mL; range, 280 pg/mL), compared to healthy volunteers (median, 28.84 pg/mL; range, 59.40 pg/mL; P < .001). Neither angiogenin nor VEGFA levels differed significantly between hemodialysis patients with and without CHD, DM, or inflammation.
  
  
  CONCLUSIONS
  Plasma angiogenin and VEGFA levels are markedly increased in hemodialysis patients, but not associated with CHD, DM, or inflammation among hemodialysis patients.
authors.affiliation: Department of Nephrology, University of Thessaly, Thessaloniki, Greece. teleftheriadis@yahoo.com
authors.forename: Theodoros
authors.initials: T
authors.lastname: Eleftheriadis
authors.forename: Georgia
authors.initials: G
authors.lastname: Antoniadi
authors.forename: Vassilios
authors.initials: V
authors.lastname: Liakopoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Pissas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Stefanidis
authors.forename: Grammati
authors.initials: G
authors.lastname: Galaktidou
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D006435:Renal Dialysis; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D002097:C-Reactive Protein; C046366:angiogenin; D012259:Ribonuclease, Pancreatic