title: Serial T-SPOT.TB and quantiFERON-TB-Gold In-Tube assays to monitor response to antitubercular treatment in Italian children with active or latent tuberculosis infection.
abstract: We performed a prospective study to investigate T-SPOT.TB and QuantiFERON-TB Gold In-Tube (QFT-G-IT) dynamics during antitubercular treatment in active tuberculosis (TB) or latent TB. Eighteen children with latent TB and 26 with TB were enrolled. At 6 months of follow-up reversion rate was 5.88% (95% CI:0-13.79) for QFT-G-IT; 9.09% (95% CI:0.59-17.58) for T-SPOT.TB (P=0.921) in TB cases. Significant decline in quantitative response was observed exclusively in TB cases. Our results suggest that serial IGRA have limited use in children receiving antitubercular treatment.
authors.affiliation: Department of Science for Woman and Child Health, Meyer University Hospital, Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Chiappini
authors.forename: Francesca
authors.initials: F
authors.lastname: Bonsignori
authors.forename: Giusi
authors.initials: G
authors.lastname: Mangone
authors.forename: Luisa
authors.initials: L
authors.lastname: Galli
authors.forename: Rachele
authors.initials: R
authors.lastname: Mazzantini
authors.forename: Sara
authors.initials: S
authors.lastname: Sollai
authors.forename: Chiara
authors.initials: C
authors.lastname: Azzari
authors.forename: Maurizio
authors.initials: M
authors.lastname: de Martino
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000378:metabolism; D059425:Interferon-gamma Release Tests / Q000379:methods*; D007558:Italy; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000276:immunology; D011446:Prospective Studies; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000995:Antitubercular Agents; D007371:Interferon-gamma