title: Evaluation of the prognosis of fulminant viral hepatitis in late pregnancy by the MELD scoring system.
abstract: The purpose of this paper was to analyze the prognosis of women with fulminant viral hepatitis in late pregnancy (FVHILP) by the Model for End-Stage Liver Disease (MELD) scoring system. A retrospective study involving patients admitted to two tertiary hospitals between January 1, 1994 and June 30, 2011 was undertaken. The relations between MELD scores and change of MELD score over time (ΔMELD) and prognosis during hospitalization were analyzed. Among the 54 patients with FVHILP, the MELD scores on admission were significantly higher in the non-survival group than those in the survival group (p < 0.05). Among the 26 FVHILP patients who underwent cesarean section, the MELD scores before and after cesarean section were both significantly higher in the non-survival group (p < 0.05). The ΔMELD scores (before operation and three days after operation) significantly increased in the non-survival group (p < 0.05). The concordance (c-statistic) values were all greater than 0.8. The MELD scoring system shows excellent short-term predictive value for the prognosis of FVHILP.
authors.affiliation: Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Deng
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Shi
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Ma
mesh_terms: D000328:Adult; D002585:Cesarean Section; D016001:Confidence Intervals; D058625:End Stage Liver Disease / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006505:Hepatitis / Q000175:diagnosis* / Q000401:mortality; D006518:Hepatitis Viruses / Q000472:pathogenicity; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000401:mortality / Q000821:virology*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D062606:Tertiary Care Centers; D013997:Time Factors; D055815:Young Adult