title: Immediate colposcopic evaluation in postmenopausal women with low-grade squamous intraepithelial lesion cytology.
abstract: OBJECTIVE
  To compare the final diagnosis among pre- and postmenopausal women with low-grade squamous intraepithelial lesion (LGSIL) cervical smear results.
  
  
  METHODS
  Retrospective, comparative study.
  
  
  METHODS
  Departments of obstetrics and gynecology in two teaching and research hospitals.
  
  
  METHODS
  Data were evaluated on 712 women with LGSIL between April 2005 and April 2011.
  
  
  METHODS
  Results from 129 postmenopausal women with LGSIL were compared with 583 premenopausal women with a similar LGSIL result with respect to sociodemographic data and histopathology.
  
  
  METHODS
  Final clinicopathological diagnosis.
  
  
  RESULTS
  The mean age of the pre- and postmenopausal women was 37.2 and 52.5 years, respectively, and lesions of cervical intraepithelial neoplasia grade 2 or worse were detected by biopsy and/or endocervical curettage in 13.6 and 9.3%, respectively. There was no significant difference between the final diagnosis among pre- and postmenopausal women with LGSIL cytology (relative risk 1.43; 95% confidence interval 0.82-2.48; p= 0.19). Invasive cervical cancer was detected in three premenopausal (0.5%) and two postmenopausal women (1.6%).
  
  
  CONCLUSIONS
  Cervical pre-invasive and invasive disease rates were similar in pre- and postmenopausal women with LGSIL cytology. For this reason, LGSIL in postmenopausal women should be considered more seriously, and colposcopic evaluation may be as acceptable an option in the management of LGSIL in this group of patients as it is with premenopausal women.
authors.affiliation: Obstetrics and Gynecology, Bakirkoy Women's and Children's Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akbayir
authors.forename: Behiye Pinar
authors.initials: BP
authors.lastname: Cilesiz Goksedef
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Numanoğlu
authors.forename: Aytul
authors.initials: A
authors.lastname: Corbacioglu
authors.forename: Volkan
authors.initials: V
authors.lastname: Ulker
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Akyol
authors.forename: Hakan
authors.initials: H
authors.lastname: Güraslan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cetin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gulkilik
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003127:Colposcopy; D003584:Cytological Techniques; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D017698:Postmenopause; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*