title: 6-hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cells.
abstract: Here we report that 6-hydroximino-4-aza-A-homo-cholest-3-one and 6-hydroxyl-4-aza-A-homo-cholest-3-one, new steroidal lactams were synthesized recently, displayed antiproliferative activity against some cancer cells through inducing cancer cell apoptosis by activation of the intrinsic pathway. The apoptotic function of the compounds was demonstrated by release of cytochrome C, activation of caspase 3 and annexin V labeling. Furthermore, the compound was able to inhibit tumor growth in an athymic mouse model.
authors.affiliation: College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China.
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Huang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cui
authors.forename: Qiaoxia
authors.initials: Q
authors.lastname: Zheng
authors.forename: Chun
authors.initials: C
authors.lastname: Zeng
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
authors.forename: Aimin
authors.initials: A
authors.lastname: Zhou
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D053148:Caspase 3 / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D045304:Cytochromes c / Q000378:metabolism; D019073:HT29 Cells; D006801:Humans; D007769:Lactams / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D017304:Annexin A5; D000970:Antineoplastic Agents; D007769:Lactams; D013256:Steroids; D045304:Cytochromes c; D053148:Caspase 3