title: EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet.
abstract: Different zinc (Zn) compounds have unique properties that may influence the amount of Zn absorbed particularly in the presence of phytic acid (PA), a common food component that binds Zn and decreases its bioavailability. In this study, 30-day-old male rats (n=12/diet group) were fed diets supplemented with PA (0.8%) and low levels (8mg Zn/kg diet) of inorganic (Zn oxide, Zn sulphate) or chelated (Zn gluconate, Zn acetate, Zn citrate, EDTA disodium Zn, Zn orotate) Zn compounds for 5 weeks. Two control groups were fed diets supplemented with low or normal (30mg Zn/kg diet) Zn (as Zn oxide) without added PA. Control rats fed the low Zn oxide diet showed depressed Zn status. Addition of PA to this diet exacerbated the Zn deficiency in rats. Growth (body weight gain and femur length) and Zn concentrations in plasma and tissues were similar in rats fed Zn oxide, Zn sulphate, Zn gluconate, Zn acetate, Zn citrate or Zn orotate. Rats fed EDTA disodium Zn showed enhanced growth compared to rats fed Zn oxide or Zn gluconate and had higher Zn concentrations in plasma and femur compared to rats fed all other Zn compounds. Only the haematological profile of rats fed EDTA disodium Zn did not differ from control rats fed normal Zn. These data indicate that in rats fed a high PA diet, bioavailability of commonly used inorganic or chelated Zn compounds does not differ appreciably, but Zn supplied as an EDTA disodium salt has superior bioavailability.
authors.affiliation: Nutrition Research Division, Health Products and Food Branch, Health Canada, Sir Frederick G. Banting Research Centre, Ottawa, Ontario, Canada. jesse.bertinato@hc-sc.gc.ca
authors.forename: Jesse
authors.initials: J
authors.lastname: Bertinato
authors.forename: Lindsey
authors.initials: L
authors.lastname: Sherrard
authors.forename: Louise J
authors.initials: LJ
authors.lastname: Plouffe
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D004492:Edetic Acid / Q000378:metabolism*; D008297:Male; D010833:Phytic Acid / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000737:chemistry / Q000378:metabolism*
chemical_list: D010833:Phytic Acid; D004492:Edetic Acid; D015032:Zinc