title: The effect of adipose-derived stem cell-cultured media on oxazolone treated atopic dermatitis-like murine model.
abstract: BACKGROUND
  A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose-derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones.
  
  
  OBJECTIVE
  We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis.
  
  
  METHODS
  ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice.
  
  
  RESULTS
  Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media-treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3.
  
  
  CONCLUSIONS
  Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.
authors.affiliation: Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Hae-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Minyoung
authors.initials: M
authors.lastname: Jung
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Na Young
authors.initials: NY
authors.lastname: Yoon
authors.forename: Eung Ho
authors.initials: EH
authors.lastname: Choi