title: Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adults.
abstract: OBJECTIVE
  To compare the effects of two regimens of GH therapy with different target IGF-1 levels on anthropometric parameters, glucose metabolism, lipid profile and cardiac function in adults with GH deficiency (GHD).
  
  
  METHODS
  Retrospective analysis of 14 GHD adults from Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil, who were treated with a GH regimen aimed at maintaining serum IGF-1 levels between the median and upper reference limit (high dose group - HDGH) and 18 GHD adults from Federal University Hospital, Curitiba, Brazil, who received a fixed GH dose of 0.2mg/day in the first year of treatment, followed by titration to maintain serum IGF-1 levels between the median and lower reference limit (low dose group - LDGH). All patients were followed for 2 years with analysis of anthropometric parameters, serum levels of IGF-1, glucose, insulin, HOMA-IR, lipid profile, and transthoracic echocardiography.
  
  
  RESULTS
  Changes on weight, BMI and waist circumference were similar between the two groups. Insulin levels increased and HOMA-IR worsened in the LDGH group at 1year and improved thereafter. Total cholesterol and triglycerides did not change with therapy. LDL cholesterol reduced in both groups, while HDL-cholesterol significantly increased only in the HDGH group (p=0.007 vs LDGH). No significant variations on echocardiographic parameters were observed.
  
  
  CONCLUSIONS
  The HDGH and LDGH regimens resulted in similar changes on anthropometric, echocardiographic, glucose and lipid parameters in GHD adults, except for increase in HDL cholesterol that was only observed in the HDGH regimen.
authors.affiliation: Endocrine Division, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. marclaudia@uol.com.br
authors.forename: Maria Claudia Peixoto
authors.initials: MC
authors.lastname: Cenci
authors.forename: Débora Vieira
authors.initials: DV
authors.lastname: Soares
authors.forename: Luciana Diniz Carneiro
authors.initials: LD
authors.lastname: Spina
authors.forename: Rosane Resende de Lima Oliveira
authors.initials: RR
authors.lastname: Brasil
authors.forename: Priscila Marise
authors.initials: PM
authors.lastname: Lobo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Michmacher
authors.forename: Mario
authors.initials: M
authors.lastname: Vaisman
authors.forename: Cesar Luiz
authors.initials: CL
authors.lastname: Boguszewski
authors.forename: Flávia Lúcia
authors.initials: FL
authors.lastname: Conceição
mesh_terms: D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D001938:Brazil; D002320:Cardiovascular Physiological Phenomena; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000172:deficiency; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol