title: Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone.
abstract: Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed pericytoma with t(7;12). To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA. jbridge@unmc.edu
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
authors.forename: Kyle
authors.initials: K
authors.lastname: Sanders
authors.forename: Dali
authors.initials: D
authors.lastname: Huang
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: James R
authors.initials: JR
authors.lastname: Neff
authors.forename: David
authors.initials: D
authors.lastname: Muirhead
authors.forename: Craig
authors.initials: C
authors.lastname: Walker
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Seemayer
authors.forename: Janos
authors.initials: J
authors.lastname: Sumegi
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D006393:Hemangiopericytoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D020286:Pericytes / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion