title: Evolving applications of microarray technology in postnatal diagnosis (review).
abstract: Microarray-based cytogenetics is revealing the tremendous fluidity and complexity             of the human genome, and is starting to illustrate the implications of genomic             variability with respect to human health and disease. In the last few years, the             robustness of array-based technologies has provided accurate diagnosis and appropriate             clinical management in a timely and efficient manner for identifying genomic defects             of congenital and developmental abnormalities including developmental delay (DD),             intellectual disability (ID), autism spectrum disorders (ASD) and/or multiple             congenital anomalies (MCA). The implementation of this technology in these categories             of disorders has been thoroughly evaluated and is now recommended as a first-line             diagnostic approach for clinically suspected genetic disorders. However, clinical             application of array-CGH in postnatal evaluation raises the debate of whether             array-CGH will replace traditional cytogenetics in the near future and whether             there is still a role for karyotyping and FISH. In this article, we therefore             review the current status of array-based technology use for postnatal diagnosis             and predict that it will replace standard cytogenetics as a first-line test for             clinical evaluation in these population groups.
authors.affiliation: Department of Biomedical Laboratory Science, Korea Nazarene University,                     Cheonan, Republic of Korea.
authors.forename: Ji Un
authors.initials: JU
authors.lastname: Kang
authors.forename: Sun Hoe
authors.initials: SH
authors.lastname: Koo
mesh_terms: D055028:Comparative Genomic Hybridization; D000013:Congenital Abnormalities / Q000175:diagnosis*; D020732:Cytogenetic Analysis; D002658:Developmental Disabilities / Q000175:diagnosis*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007231:Infant, Newborn; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011181:Postnatal Care