title: An MRI study of amygdala in schizophrenia and psychotic bipolar disorder.
abstract: Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p=0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. pbelmon2@jhmi.edu
authors.forename: Pamela Belmonte
authors.initials: PB
authors.lastname: Mahon
authors.forename: Haley
authors.initials: H
authors.lastname: Eldridge
authors.forename: Britni
authors.initials: B
authors.lastname: Crocker
authors.forename: Lisa
authors.initials: L
authors.lastname: Notes
authors.forename: Holly
authors.initials: H
authors.lastname: Gindes
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Postell
authors.forename: Stacey
authors.initials: S
authors.lastname: King
authors.forename: James B
authors.initials: JB
authors.lastname: Potash
authors.forename: J Tilak
authors.initials: JT
authors.lastname: Ratnanather
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Barta
mesh_terms: D000328:Adult; D000679:Amygdala / Q000473:pathology*; D001714:Bipolar Disorder / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012559:Schizophrenia / Q000473:pathology*