title: [Analysis of risk factors of drug-induced lung injury in patients receiving gemcitabine treatment].
abstract: Gemcitabine hydrochloride is a very safe medicine that even outpatients can be administered, and the bone marrow depression that is the dose limiting factor remains moderate and does not need special treatment, although it is confirmed in most cases. Meanwhile, caution is required because there is a possibility of drug-induced lung injury and death due to high frequency, compared with the appearance rate described in the packaging insertion. We investigated the clinical background of a patient in whom drug-induced lung injury appeared, and clarified the risk factor by administering gemcitabine hydrochloride. Males, people aged 65 or over, those with a smoking history and those undergoing first-line chemotherapy treatment are at risk of drug-induced lung injury. Attention must be paid to the occurrence of drug-induced lung injury, to examining the clinical course, the chest image, and the blood test, and to do earlier detection, the offending medicine discontinuance, and beginning of the treatment.
authors.affiliation: Department of Pharmacy, Seirei Hamamatsu General Hospital.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakamichi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujita
authors.forename: Daiki
authors.initials: D
authors.lastname: Tsuji
authors.forename: Ichiko
authors.initials: I
authors.lastname: Atsumi
authors.forename: Kasumi
authors.initials: K
authors.lastname: Totsuka
authors.forename: Rina
authors.initials: R
authors.lastname: Suzuki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tomita
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakamura
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Shiokawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000009:adverse effects; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D012307:Risk Factors; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine