title: [Toxoplasmic cyst and heart transplant: a case report of serological reactivation in an acute graft rejection context].
abstract: We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. Then, we draw up a brief review of the bibliographical literature about pathophysiological mechanisms of toxoplasmic reactivation in heart transplants.
authors.affiliation: Service de parasitologie-mycologie-médecine tropicale, CHRU de Tours. guillaume.desoubeaux@univ-tours.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Desoubeaux
authors.forename: Kévin
authors.initials: K
authors.lastname: Perret-Gallix
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Machet
authors.forename: Agnès
authors.initials: A
authors.lastname: Sirinelli
authors.forename: Eric
authors.initials: E
authors.lastname: Bailly
authors.forename: Nathalie
authors.initials: N
authors.lastname: Van Langendonck
authors.forename: Jacques
authors.initials: J
authors.lastname: Chandenier
mesh_terms: D000208:Acute Disease; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D006084:Graft Rejection / Q000209:etiology* / Q000276:immunology / Q000469:parasitology; D016027:Heart Transplantation / Q000009:adverse effects* / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012699:Serology; D014019:Tissue Donors; D014122:Toxoplasma / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D014123:Toxoplasmosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan