title: Association between polycystic ovarian syndrome, overweight, and metabolic syndrome in adolescents.
abstract: OBJECTIVE
  Polycystic syndrome (PCOS) is associated with multiple metabolic abnormalities. Studies in the adolescent population are still limited and the results have been much different. The aim of this study was to investigate the association between PCOS, overweight, and metabolic syndrome in adolescents.
  
  
  METHODS
  30 PCOS adolescents were randomly selected from a PCOS population with NIH 1990 criteria and 71 adolescents from the normal adolescents. Anthropometric, hormonal and metabolic parameters were evaluated in four sub-groups including obese and non-obese PCOS and obese and non-obese normal adolescents.
  
  
  RESULTS
  The prevalence of overweight and metabolic syndrome in adolescents with PCOS was 52% and 33.3% respectively vs 22.4% (P = 0.005) and 11.26% in control (normal) adolescents (P = 0.0001). Among all subjects, including obese and non-obese adolescents with or without PCOS, the prevalence of insulin resistance, hypercholesterolemia, central obesity, and metabolic syndrome was higher in obese PCOS with 61.5%, 46.2%, 53.8%, and 69.2%, respectively.
  
  
  CONCLUSIONS
  Obesity and IR are important risk factors for metabolic syndrome in PCOS. Considering the long-term health risks, it is necessary to identify metabolic disorders in adolescents with PCOS as early as possible.
authors.affiliation: Zanjan Metabolic Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. haleh509@gmail.com
authors.forename: Haleh
authors.initials: H
authors.lastname: Rahmanpour
authors.forename: Leila
authors.initials: L
authors.lastname: Jamal
authors.forename: Seyed Nouraddin
authors.initials: SN
authors.lastname: Mousavinasab
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Esmailzadeh
authors.forename: Kamran
authors.initials: K
authors.lastname: Azarkhish
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D050177:Overweight / Q000453:epidemiology / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors