title: Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum.
abstract: The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
authors.affiliation: Stiftungsprofessur für Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Straße 9, D-60438 Frankfurt a. M., Germany.
authors.forename: Friederike I
authors.initials: FI
authors.lastname: Nollmann
authors.forename: Andrea
authors.initials: A
authors.lastname: Dowling
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Klaus
authors.initials: K
authors.lastname: Deckmann
authors.forename: Sabine
authors.initials: S
authors.lastname: Grösch
authors.forename: Richard
authors.initials: R
authors.lastname: Ffrench-Constant
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode