title: Treatment of obstructive sleep apnea with continuous positive airway pressure decreases adipocyte fatty acid-binding protein levels.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) can be associated with the metabolic syndrome. Adipocyte fatty acid-binding protein (A-FABP) may play a role in OSA. The aim of this study was to determine whether continuous positive airway pressure (CPAP) treatment results in decreased serum A-FABP levels.
  
  
  METHODS
  81 patients (70 males, a mean age of 53.9±10.3 years) were evaluated by polysomnography, diagnosed with OSA and indicated for CPAP treatment. Anthropometric, clinical and laboratory investigations were carried out and repeated after 1 month/ 1 year of CPAP treatment. The data were analyzed using the SPSS Statistics 15 software (SPSS Inc., Chicago, USA).
  
  
  RESULTS
  Patients had significantly decreased A-FABP levels (34.4 ng/ml, 31.2 ng/ml, 24.8 ng/ml, P=0.048, P=0.001) and improved OSA parameters: AHI (53.9, 5.0, 5.6, P<0.0001), mean nocturnal oxygen saturation (91%, 93%, 94%, P<0.0001), ODI (55, 9, 8, P<0.0001), and percentage of sleep time with oxygen saturation below 90% (28.2, 0.2, 0, P<0.0001). BMI, waist, neck circumference, and blood pressure did not statistically significantly change.
  
  
  CONCLUSIONS
  CPAP therapy in OSA patients has a positive effect on A-FABP levels. Decreased A-FABP levels play an important role in regulating glucose metabolism and affect the regulation of lipid metabolism and thus may contribute to decrease in the cardiovascular complications of OSA.
authors.affiliation: Department of Internal Medicine I - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. Eliska.sovova@seznam.cz
authors.forename: Eliska
authors.initials: E
authors.lastname: Sovova
authors.forename: Milada
authors.initials: M
authors.lastname: Hobzova
authors.forename: David
authors.initials: D
authors.lastname: Stejskal
authors.forename: Milan
authors.initials: M
authors.lastname: Sova
authors.forename: Vitezslav
authors.initials: V
authors.lastname: Kolek
authors.forename: Jana
authors.initials: J
authors.lastname: Zapletalova
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D001794:Blood Pressure; D045422:Continuous Positive Airway Pressure; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D010100:Oxygen