title: The relation between Parkinson's disease and ageing. Comparison of the gait patterns of young Parkinson's disease subjects with healthy elderly subjects.
abstract: BACKGROUND
  The gait of healthy elderly and of subjects with Parkinson's disease (PD) displays some common features, suggesting that PD may be a model of ageing.
  
  
  OBJECTIVE
  The aim of the study was to quantify highlight the differences and similarities between the gait patterns of young PD and healthy elderly, to uncover if PD could be assumed as a model of ageing.
  
  
  METHODS
  An optoelectronic system was used for 3D gait analysis evaluation.
  
  
  METHODS
  We compared the gait parameters of 15 young PD (YPD) with the gait of 32 healthy elderly subjects (ES) and 21 healthy subjects age-matched with the PD subjects. RESULTS. Common features between YPD and ES were majorly found in the parameters that reflect the presence of an unstable, uncertain gait, and of corrective strategies employed to reduce instability. On the other side, typical features were present in the gait patterns of PD subjects. CONCLUSION. Our study helped identifying some typical characteristics of the onset disease, and to unravel the symptoms of ageing from those of PD by comparing young PD subjects to elderly healthy subjects.
  
  
  CONCLUSIONS
  This allows a deeper understanding of the mechanisms underlying the gait in ageing and PD.
authors.affiliation: IRCCS San Raffaele, Rome, Italy. patrizio.sale@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Sale
authors.forename: M F
authors.initials: MF
authors.lastname: De Pandis
authors.forename: S L
authors.initials: SL
authors.lastname: Vimercati
authors.forename: I
authors.initials: I
authors.lastname: Sova
authors.forename: C
authors.initials: C
authors.lastname: Foti
authors.forename: N
authors.initials: N
authors.lastname: Tenore
authors.forename: M
authors.initials: M
authors.lastname: Fini
authors.forename: F
authors.initials: F
authors.lastname: Stocchi
authors.forename: G
authors.initials: G
authors.lastname: Albertini
authors.forename: M
authors.initials: M
authors.lastname: Franceschini
authors.forename: M
authors.initials: M
authors.lastname: Galli
mesh_terms: D000368:Aged; D000375:Aging; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D020233:Gait Disorders, Neurologic / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*