title: Three-component organocascade kinetic resolution of racemic nitroallylic acetates via sequential iminium/enamine asymmetric catalysis.
abstract: Nitroallylic acetates 1a-f have been kinetically resolved via an asymmetric three-component coupling that involves indoles, acrolein, and nitroolefin allylic acetates and is mediated by the chiral catalyst 2 (5 mol %). The reactions proceed via iminium/enamine cascade catalysis. Both recovered starting substrates and reaction products are typically obtained in high chemical yield and in good to excellent enantiopurity (79-95% ee for 1a-f and 83-99% ee for 3a-n). For the first time, a highly efficient three-component, organocascade kinetic resolution has been demonstrated.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, ROC.
authors.forename: Suparna
authors.initials: S
authors.lastname: Roy
authors.forename: Kwunmin
authors.initials: K
authors.lastname: Chen