title: Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases.
abstract: OBJECTIVE
  To investigate the prognostic significance of histopathological characteristics in patients with biopsy-proven rheumatoid lung disease (RLD).
  
  
  METHODS
  Retrospective analysis was conducted on samples from 54 RLD patients who underwent surgical lung biopsies (SLBs) at Hamamatsu University Hospital and affiliated hospitals between 1980 and 2009. The overall survival rate, the spectrum of histopathological diagnosis and their associated prognostic significance were investigated.
  
  
  RESULTS
  The study group consisted of 30 men and 24 women with a median age of 60.3 years. Histopathological analysis revealed the following: usual interstitial pneumonia (UIP), 15 cases; nonspecific interstitial pneumonia/fibrosis, 16 cases; organizing pneumonia, 4 cases; unclassifiable, 2 cases; desquamative interstitial pneumonia, 1 case; and bronchiolar disease, 16 cases. In survival outcome, 10 yr survival rate was 76.6%. Patients with UIP had significantly worse prognosis than those with non-UIP (RLD cases except those with UIP) (p = 0.0452).
  
  
  CONCLUSIONS
  RLD includes several histopathological groups. Patients with UIP have worse survival than those with other types of RLD. Histopathological diagnosis may have a major impact on prognostication in patients with RLD.
authors.affiliation: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan. nakayuta@hama-med.ac.jp
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kaida
authors.forename: Masato
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authors.lastname: Kono
authors.forename: Hironao
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authors.lastname: Hozumi
authors.forename: Dai
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authors.lastname: Hashimoto
authors.forename: Noriyuki
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authors.lastname: Enomoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Naoki
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authors.lastname: Inui
authors.forename: Shiro
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authors.lastname: Imokawa
authors.forename: Kazumasa
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authors.lastname: Yasuda
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shirai
authors.forename: Hideki
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authors.lastname: Suganuma
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Yasuo
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authors.lastname: Takehara
authors.forename: Thomas V
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authors.lastname: Colby
authors.forename: Kingo
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authors.lastname: Chida
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001706:Biopsy; D002423:Cause of Death; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods