title: Volumetric intraoperative brain deformation compensation: model development and phantom validation.
abstract: During neurosurgery, nonrigid brain deformation may affect the reliability of tissue localization based on preoperative images. To provide accurate surgical guidance in these cases, preoperative images must be updated to reflect the intraoperative brain. This can be accomplished by warping these preoperative images using a biomechanical model. Due to the possible complexity of this deformation, intraoperative information is often required to guide the model solution. In this paper, a linear elastic model of the brain is developed to infer volumetric brain deformation associated with measured intraoperative cortical surface displacement. The developed model relies on known material properties of brain tissue, and does not require further knowledge about intraoperative conditions. To provide an initial estimation of volumetric model accuracy, as well as determine the model's sensitivity to the specified material parameters and surface displacements, a realistic brain phantom was developed. Phantom results indicate that the linear elastic model significantly reduced localization error due to brain shift, from > 16 mm to under 5 mm, on average. In addition, though in vivo quantitative validation is necessary, preliminary application of this approach to images acquired during neocortical epilepsy cases confirms the feasibility of applying the developed model to in vivo data.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY 10032, USA. christine.delorenzo@aya.yale.edu
authors.forename: Christine
authors.initials: C
authors.lastname: DeLorenzo
authors.forename: Xenophon
authors.initials: X
authors.lastname: Papademetris
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Staib
authors.forename: Kenneth P
authors.initials: KP
authors.lastname: Vives
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Spencer
authors.forename: James S
authors.initials: JS
authors.lastname: Duncan
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology; D005716:Game Theory; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008959:Models, Neurological; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012886:Skull / Q000033:anatomy & histology; D025321:Surgery, Computer-Assisted