title: The association of oxidative stress with hypertensive retinopathy.
abstract: This study was designed to answer the following questions: (i) Do levels of serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, change in hypertensive retinopathy (HR)? (ii) Is there any relation between degree of HR and GGT levels? This study included 80 hypertensive patients with HR. Group 1 comprised 40 patients with grade I HR, and group 2 comprised 40 patients with grade II HR. We selected 40 healthy subjects for the control group. Level of GGT in group 2 was significantly higher than in group 1 (P = 0.005) and control group (P = 0.001); it was also higher in group 1 than in control group (P = 0.025). Our study suggests that oxidative stress, mechanisms known to be involved in vascular lesions, may promote the development of HR.
authors.affiliation: Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karaca
authors.forename: Erkan
authors.initials: E
authors.lastname: Coban
authors.forename: Rasih
authors.initials: R
authors.lastname: Felek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Unal
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D058437:Hypertensive Retinopathy / Q000097:blood* / Q000201:enzymology* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D005723:gamma-Glutamyltransferase