title: New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity.
abstract: The synthesis and biological activity of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with tuftsin and retro-tuftsin derivatives containing isopeptide bond between ε-amino group of lysine and carboxyl group of simple amino acids such as Ala, Gly and Val are presented. We presumed, based on the cytokine profile, that the examined conjugates of tuftsin and MDP were capable of activating antibacterial mechanisms by switching on Th1 immune response. The most active were compounds 11, 14 and 19-23.
authors.affiliation: Department of Organic Chemistry, Gdansk University of Technology, G. Narutowicza 11/12, PL 80-233 Gdańsk, Poland. kd@chem.pg.gda.pl
authors.forename: Krystyna
authors.initials: K
authors.lastname: Dzierzbicka
authors.forename: Anna
authors.initials: A
authors.lastname: Wardowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rogalska
authors.forename: Piotr
authors.initials: P
authors.lastname: Trzonkowski
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D000596:Amino Acids / Q000737:chemistry; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D018417:Th1 Cells / Q000187:drug effects / Q000378:metabolism; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D016207:Cytokines; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D014405:Tuftsin