title: Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension.
abstract: The information needed to diagnose pulmonary arterial hypertension (PAH) in dogs based on N-terminal pro B-type natriuretic peptide (NT-proBNP) and atrial natriuretic peptide (ANP) levels is unclear. In this study, serial changes in plasma NT-proBNP and ANP concentrations were evaluated in association with the development of chronic embolic pulmonary hypertension (CEPH). Six Beagle dogs underwent percutaneous pulmonary artery catheterization. CEPH was induced by the repeated injection of 300 μm microspheres into the pulmonary artery via the catheter. Measured peak systolic pulmonary arterial pressure (PAPs) was elevated up to 80 mm Hg at 90 days by repeated injection of microspheres. Echocardiographic examination showed significant increase in the main pulmonary artery enlargement, right ventricular dilation, transtricuspid late diastolic flow, and ventricular late diastolic myocardial velocity. Plasma concentrations of NT-proBNP and ANP were significantly increased by microsphere-induced severe CEPH, but not by mild CEPH. Measured PAPs correlated weakly with plasma NT-proBNP and ANP concentrations (r=0.63 and 0.69, respectively) and with several echocardiographic variables. Our results indicated that plasma ANP and NT-proBNP responded to severe PAH, but that they were not sensitive for mild PAH.
authors.affiliation: Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan. hori@vmas.kitasato-u.ac.jp
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Hori
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Uchide
authors.forename: Ryuta
authors.initials: R
authors.lastname: Saitoh
authors.forename: Daisuke
authors.initials: D
authors.lastname: Thoei
authors.forename: Makiko
authors.initials: M
authors.lastname: Uchida
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Seishiro
authors.initials: S
authors.lastname: Chikazawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Hoshi
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008863:Microspheres; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011651:Pulmonary Artery / Q000473:pathology / Q000503:physiopathology; D011655:Pulmonary Embolism / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor