title: The pathophysiology and clinical presentation of cerebral amyloid angiopathy.
abstract: Cerebral amyloid angiopathy (CAA) is defined as the deposition of amyloid ß peptide within leptomeningial and cortical vessels, likely reflecting an imbalance between Aβ production and clearance. Amyloid buildup triggers a series of destructive alterations in the cerebral vascular architecture, leading to a spectrum of neurological events including lobar intracerebral hemorrhage, brain ischemia and cognitive decline. Although traditionally diagnosed pathologically, neuroimaging has taken a central role in defining CAA. This review will discuss the pathological, clinical and radiological aspects of CAA.
authors.affiliation: J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston, 02114, USA.
authors.forename: Eitan
authors.initials: E
authors.lastname: Auriel
authors.forename: Steven Mark
authors.initials: SM
authors.lastname: Greenberg
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D015140:Dementia, Vascular / Q000209:etiology*; D006801:Humans; D020521:Stroke / Q000209:etiology*
chemical_list: D016229:Amyloid beta-Peptides