title: Age-related distributions of anti-Müllerian hormone level and anti-Müllerian hormone models.
abstract: OBJECTIVE
  To determine age-specific reference values for anti-Müllerian hormone (AMH) and to set up an optimal model for AMH changes by age for infertility investigations.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Several infertility clinics and two university hospitals.
  
  
  METHODS
  A total of 21 226 AMH samples were obtained.
  
  
  METHODS
  Data on patients' age, race/ethnicity, and AMH levels were available from the laboratory center data registry between November 2008 and January 2011.
  
  
  METHODS
  The distribution of AMH levels by age. From 16 972 women aged between 25 and 45 years, we established and validated five AMH-age regression models.
  
  
  RESULTS
  The overall mean AMH level was 4.09 ± 3.71 ng/mL (median: 3.13 ng/mL). There was an inverse relation between AMH level and age. Among multiple regression models, the quadratic model was most appropriate to describe AMH-age relation (log AMH = 0.205 × age - 0.005 × age(2) - 0.047).
  
  
  CONCLUSIONS
  AMH levels show a progressive decline with increasing age. Age-specific AMH values may provide more specific information useful for patients and clinicians. AMH-age models could play a role as a basic step to approach more accurate ovarian reserve estimation.
authors.affiliation: Hamchoon Women's Clinic, Seoul, Korea.
authors.forename: Joong Yeup
authors.initials: JY
authors.lastname: Lee
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Jung Ryeol
authors.initials: JR
authors.lastname: Lee
authors.forename: Chung Hyon
authors.initials: CH
authors.lastname: Kim
authors.forename: Taesung
authors.initials: T
authors.lastname: Park
authors.forename: Bo Ra
authors.initials: BR
authors.lastname: Yeon
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Seo
authors.forename: Won Don
authors.initials: WD
authors.lastname: Lee
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000375:Aging / Q000097:blood*; D000704:Analysis of Variance; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D015233:Models, Statistical; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D056910:Republic of Korea; D018709:Statistics, Nonparametric
chemical_list: D054304:Anti-Mullerian Hormone