title: A hypothesis: Edaravone exert cardioprotection partly via modulation of adiponectin.
abstract: Edaravone has been recognized as a potential protective agent for cardiovascular diseases. It is well known that edaravone can attenuate oxidative stress and inhibit the production of proinflammatory cytokines such as TNF-α. However, the mechanisms behind the cardioprotection of edaravone are still incompletely understood yet. As a primary adipose-derived protein, adiponectin exhibits protective properties on the heart and blood vessels. Accumulative studies have shown that there exists a reciprocal relationship between adiponectin and TNF-α, i.e., adiponectin negatively regulates TNF-α expression, whereas adiponectin expression is inhibited by TNF-α. So we hypothesize that edaravone plays a role in cardioprotection partly through modulation of adiponectin level by suppression of TNF-α.
authors.affiliation: Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Pei
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.forename: Lu
authors.initials: L
authors.lastname: Sun
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhou
mesh_terms: D052242:Adiponectin / Q000276:immunology*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000276:immunology*; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D018448:Models, Immunological; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D052242:Adiponectin; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D014409:Tumor Necrosis Factor-alpha; D000077553:Edaravone; D000983:Antipyrine