title: Anti-ribosomal P antibody in schizophrenia.
abstract: BACKGROUND
  A series of epidemiological, clinical and laboratory findings suggest an autoimmune process in schizophrenia and include, among others, high titers of various autoantibodies in the sera of patients. Antiribosomal P antibody is known to exist in systemic lupus erythematosus (SLE) patients with a psychiatric presentation, including psychosis, rationalizing the examination of its existence in patients with schizophrenia.
  
  
  METHODS
  Sera of 59 patients, 48 diagnosed with schizophrenia and 11 diagnosed with a schizoaffective disorder, were examined for the presence of antiribosomal P antibody titers using ELISA. The control group consisted of 94 healthy subjects with similar age and gender distribution.
  
  
  RESULTS
  Anti-ribosomal P antibody titers were below cut-off level in 58 patients and borderline in one patient, similar to the low titers of the control group.
  
  
  CONCLUSIONS
  Previous investigations have demonstrated high specificity for anti-ribosomal P antibody in SLE patients with psychosis. In view of the results of this study, however, anti-ribosomal P antibody is not a biological marker for schizophrenia.
authors.affiliation: Brill Mental Health Community Center, Ramat Chen, Tel Aviv, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Gilat
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
authors.forename: Moshe
authors.initials: M
authors.lastname: Kotler
authors.forename: Iulian
authors.initials: I
authors.lastname: Iancu
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000097:blood / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*; D012559:Schizophrenia / Q000097:blood / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D012269:Ribosomal Proteins