title: Losing balance: the origin and impact of aneuploidy in cancer.
abstract: Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.
authors.affiliation: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0670, USA. a1holland@ucsd.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Holland
authors.forename: Don W
authors.initials: DW
authors.lastname: Cleveland
mesh_terms: D059786:Abnormal Karyotype; D000782:Aneuploidy; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D020090:Chromosome Segregation; D042822:Genomic Instability; D006801:Humans; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology