title: Distribution of hepatitis C virus genotypes in haemodialysis patients of Guilan, northern Islamic Republic of Iran.
abstract: The hepatitis C virus (HCV) infection among patients undergoing haemodialysis is high. The aim of this study was to identify the HCV genotypes among chronic haemodialysis patients who were HCV positive in Guilan province, northern Islamic Republic of Iran. All patients on haemodialysis at Guilan haemodialysis centres were enrolled. Enzyme-linked immunosorbent assay and polymerase chain reactio testing were performed. Out of 514 enrolled patients, 11.9% were serologically HCV positive and 6.2% had positive HCV-RNA. HCV genotypes were determined with HCV genotype-specific primers. The most frequent genotypes were 1a (59.4%) and 3a (40.6%). There was no significant relationship between virus genotypes and sex or age. The HCV genotype pattern among haemodialysis patients in Guilan province was different from other countries of the Middle East and was more similar to North American and European countries where genotype 1 is predominant.
authors.affiliation: Gastrointestinal and Liver Diseases Research Centre, Guilan University of Medical Sciences, Guilan, Islamic Republic of Iran.
authors.forename: F
authors.initials: F
authors.lastname: Joukar
authors.forename: A K
authors.initials: AK
authors.lastname: Khalesi
authors.forename: R
authors.initials: R
authors.lastname: Jafarshad
authors.forename: M S
authors.initials: MS
authors.lastname: Rahimabadi
authors.forename: F
authors.initials: F
authors.lastname: Mansour-Ghanaei
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D018937:Hepatitis C Antibodies / Q000097:blood / Q000235:genetics; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D018937:Hepatitis C Antibodies