title: High level production of 5-aminolevulinic acid by Propionibacterium acidipropionici grown in a low-cost medium.
abstract: 5-Aminolevulinic acid (ALA) is an intermediate in the biosynthesis of tetrapyrroles. Its current production is expensive. We have developed a low-cost medium for Propionibacterium acidipropionici to produce extracellular ALA. When grown at 35 °C on a medium containing 3 % (w/v) food-grade sodium lactate supplemented with 18 g glycine/l, 4.05 g succinate/l, 1.8 g glucose/l, pH 7, it produced ALA up to 7.7 g/l over 6 days. Plant-growth promoting activity assays showed that the ALA was biologically active.
authors.affiliation: Department of Microbiology, Faculty of Science, Silpakorn University, Nakhonpathom 73000, Thailand. sonhom.r.sc@gmail.com
authors.forename: Rossukon
authors.initials: R
authors.lastname: Sonhom
authors.forename: Chockpisit
authors.initials: C
authors.lastname: Thepsithar
authors.forename: Boonsri
authors.initials: B
authors.lastname: Jongsareejit
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry* / Q000191:economics*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D011424:Propionibacterium / Q000378:metabolism*; D019354:Sodium Lactate / Q000378:metabolism; D019802:Succinic Acid / Q000378:metabolism; D013696:Temperature
chemical_list: D003470:Culture Media; D000622:Aminolevulinic Acid; D019802:Succinic Acid; D005947:Glucose; D005998:Glycine; D019354:Sodium Lactate