title: Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer.
abstract: Genome-wide association studies have identified 16 germline single-nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC) incidence. We examined the relationship between these SNPs and survival of 2611 individuals with CRC, enrolled in 5 cohort studies. We used Cox regression analysis to associate SNPs with overall and CRC-specific survival times. The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival (hazard ratio, 1.16; 95% confidence interval, 1.06-1.27; P = .002) and disease-specific survival (hazard ratio, 1.17; 95% confidence interval, 1.05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.
authors.affiliation: Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Amanda I
authors.initials: AI
authors.lastname: Phipps
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
authors.forename: Xabier
authors.initials: X
authors.lastname: Garcia-Albeniz
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Hutter
authors.forename: Emily
authors.initials: E
authors.lastname: White
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.forename: Aditi
authors.initials: A
authors.lastname: Hazra
authors.forename: Shuji
authors.initials: S
authors.lastname: Ogino
authors.forename: Hongmei
authors.initials: H
authors.lastname: Nan
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Peter T
authors.initials: PT
authors.lastname: Campbell
authors.forename: Jane C
authors.initials: JC
authors.lastname: Figueiredo
authors.forename: Ulrike
authors.initials: U
authors.lastname: Peters
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Chan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D051906:Smad7 Protein / Q000235:genetics*; D016019:Survival Analysis
chemical_list: C497806:SMAD7 protein, human; D051906:Smad7 Protein