title: Incremental increases in glucocorticoid doses may reduce the risk of osmotic demyelination syndrome in a patient with hyponatremia due to central adrenal insufficiency.
abstract: A 50-year-old man was admitted to our hospital because of general malaise. Laboratory tests revealed severe hyponatremia (104 mEq/L), which was attributed to central adrenal insufficiency. To treat presumed central diabetes insipidus (CDI), we administered a small dose of hydrocortisone and gradually increased it to maintenance doses to prevent osmotic demyelination syndrome (ODS). Serum sodium levels did not increase more than 10 mEq/L/day and ODS did not occur. Thereafter, the patient was proven to have CDI. Incremental increases in glucocorticoid dose may reduce the risk of ODS for patients with hyponatremia due to central adrenal insufficiency, especially that complicated by CDI.
authors.affiliation: Department of Internal Medicine, Osaka City Sumiyoshi Hospital, Japan. kmyoshi@rr.iij4u.or.jp
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Mieko
authors.initials: M
authors.lastname: Minami
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Seiko
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Adachi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamagami
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications / Q000188:drug therapy*; D003711:Demyelinating Diseases / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009995:Osmosis; D012307:Risk Factors; D013577:Syndrome
chemical_list: D005938:Glucocorticoids