title: Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications.
abstract: The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass-based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified Stöber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid.
authors.affiliation: Department of Metallurgical Engineering and Materials, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. agdalinero@yahoo.com
authors.forename: Agda Aline Rocha
authors.initials: AA
authors.lastname: de Oliveira
authors.forename: Sandhra Maria
authors.initials: SM
authors.lastname: de Carvalho
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Leite
authors.forename: Rodrigo Lambert
authors.initials: RL
authors.lastname: Oréfice
authors.forename: Marivalda de Magalhães
authors.initials: Mde M
authors.lastname: Pereira
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D051381:Rats; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D011140:Polyurethanes