title: Surgical treatment for primary angle closure-glaucoma: a Meta analysis.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of trabeculectomy, phacotrabeculectomy plus intraocular lens implantation(phacotrab+IOL group) and phacoemulsification with IOL(phaco+IOL) in primary angle-closure glaucoma(PACG).
  
  
  METHODS
  It was a systematic review and meta-analysis, randomized controlled trials(RCT) and clinical controlled trials(CCT) were collected through electronic searches of the Cochrane Library, PubMed, EMbase, Wanfang Database online, Chinese journal Full-text Database, Chinese Scientific Journals Full-text Database (from the date of building the database to October 2010) We also checked the bibliographies of retrieved articles. All the related data that matched our standards were abstracted. The quality of included trials was evaluated according to the Dutch Cochrane Centre. RevMan 5.0 software was used for Meta-analysis.
  
  
  RESULTS
  A total of 5 RCT and 11 CCT involving 1495 eyes were included. The results of meta-analysis showed that phacotrab+IOL group was superior than trabeculectomy(trab group) (MD -3.93,95%CI [-7.31, -0.54]) which was also superior than phaco+IOL group(MD 0.52,95%CI [0.10, 0.95]) in decreasing Intraocular Pressure(IOP). Phacotrab group(MD -1.45,95%CI [-1.68, -1.22])and phaco group (MD-1.12,95%CI [-1.87, -0.37])are both deeper than trab group in the anterior chamber depth. In increasing the coefficient of outflow facility of aqueous humor(C values) there was no statistical difference in the three groups. And there was no statistical difference between phacotrab groups and phaco groups in visual acuity but phacotrab group was superior than phaco group (MD 1.07, 95%CI [0.73, 1.40])in the use of IOP-lowering drugs. There was no statistical difference among three groups.
  
  
  CONCLUSIONS
  Current evidence suggests that phacotrab+ IOL group was superior than trab group which was also superior than phaco+IOL group in decreasing IOP. Phacotrab group and phaco group are both deeper than trab group in the anterior chamber depth. Phacotrab group was superior than phaco group in the use of IOP-lowering drugs.
authors.affiliation: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China.
authors.forename: Bo-Lin
authors.initials: BL
authors.lastname: Deng
authors.forename: Cheng
authors.initials: C
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Ma
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Lü
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Du
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Jiu
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Tian