title: Parkinsonian motor features distinguish the agrammatic from logopenic variant of primary progressive aphasia.
abstract: BACKGROUND
  Few studies have assessed parkinsonian motor features across variants of primary progressive aphasia (PPA). Our objective was to compare degree of parkinsonian motor features between two PPA variants.
  
  
  METHODS
  Parkinsonian motor features were assessed with the unified Parkinson's disease rating scale in prospectively recruited PPA subjects, classified based on recently published criteria. Comparisons across groups were performed with Fisher's exact test for binary data and Mann-Whitney U test for continuous data.
  
  
  RESULTS
  Twenty-three PPA subjects were diagnosed with logopenic (n = 11) or nonfluent/agrammatic (n = 12) aphasia. There were no significant differences in illness duration (agrammatic = 3.4 years; logopenic = 3.3 years) or age at onset (nonfluent/agrammatic = 67.3; logopenic = 62.0), but those with logopenic aphasia were more impaired on mini-mental state examination (21.7/30 points vs. 26.1/30; p = 0.04). In contrast, those with logopenic aphasia had fewer parkinsonian motor features than those with agrammatic aphasia (5.7/132 vs. 16.8/132; p = 0.003) which was driven by bradykinesia (p = 0.02) and speech facial/expression (p = 0.04); less so rigidity (p = 0.06). Dysarthria was more frequent in the nonfluent/agrammatic subgroup.
  
  
  CONCLUSIONS
  Nonfluent/agrammatic subjects have more parkinsonian motor features than logopenic subjects, likely reflecting underlying tau pathology in the agrammatic variant.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Graff-Radford
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Duffy
authors.forename: Edythe A
authors.initials: EA
authors.lastname: Strand
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000368:Aged; D001039:Aphasia, Broca / Q000175:diagnosis* / Q000503:physiopathology; D018888:Aphasia, Primary Progressive / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D007807:Language Tests; D009043:Motor Activity / Q000502:physiology*; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000503:physiopathology; D013060:Speech / Q000502:physiology