title: Association of TCF7L2 and ADIPOQ with body mass index, waist-hip ratio, and systolic blood pressure in an endogamous ethnic group of India.
abstract: Despite the increasing burden of type 2 diabetes (T2D) and its established association with anthropometric and physiological traits as a risk factor, genetic studies focusing on the association of T2D-related genes with quantitative traits like body mass index (BMI), waist-hip ratio (WHR), and systolic blood pressure (SBP) are only a few for western populations and rare for Indian populations. The present study tested the association of TCF7L2, HHEX, KCNJ11, and ADIPOQ with BMI, SBP, and WHR in men and women of the Aggarwal population of India and found a differential association of TCF7L2 (rs7903146, rs4506565, and rs12256372) and ADIPOQ (rs2241766 and rs1501299) genes with increasing BMI, SBP, and WHR between the two sexes. We conclude that TCF7L2 and ADIPOQ together might play an important role in explaining these traits and to understand the biological and genetic mechanisms underlying T2D, and the role of other T2D genes must also be evaluated with these continuous traits.
authors.affiliation: South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India. udaiig@gmail.com
authors.forename: Vipin
authors.initials: V
authors.lastname: Gupta
authors.forename: Rajesh
authors.initials: R
authors.lastname: Khadgawat
authors.forename: H K Tony
authors.initials: HK
authors.lastname: Ng
authors.forename: Gagandeep Kaur
authors.initials: GK
authors.lastname: Walia
authors.forename: Leena
authors.initials: L
authors.lastname: Kalla
authors.forename: Vadlamudi Raghavendra
authors.initials: VR
authors.lastname: Rao
authors.forename: Mohinder Pal
authors.initials: MP
authors.lastname: Sachdeva
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D013599:Systole; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*; D049629:Waist-Hip Ratio
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein