title: A gantry-based tri-modality system for bioluminescence tomography.
abstract: A gantry-based tri-modality system that combines bioluminescence (BLT), diffuse optical (DOT), and x-ray computed tomography (XCT) into the same setting is presented here. The purpose of this system is to perform bioluminescence tomography using a multi-modality imaging approach. As parts of this hybrid system, XCT and DOT provide anatomical information and background optical property maps. This structural and functional a priori information is used to guide and restrain bioluminescence reconstruction algorithm and ultimately improve the BLT results. The performance of the combined system is evaluated using multi-modality phantoms. In particular, a cylindrical heterogeneous multi-modality phantom that contains regions with higher optical absorption and x-ray attenuation is constructed. We showed that a 1.5 mm diameter bioluminescence inclusion can be localized accurately with the functional a priori information while its source strength can be recovered more accurately using both structural and the functional a priori information.
authors.affiliation: Tu and Yuen Center for Functional Onco-Imaging and Department of Radiological Sciences, University of California, Irvine, California 92697, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.forename: Yuting
authors.initials: Y
authors.lastname: Lin
authors.forename: William C
authors.initials: WC
authors.lastname: Barber
authors.forename: Mehmet Burcin
authors.initials: MB
authors.lastname: Unlu
authors.forename: Gultekin
authors.initials: G
authors.lastname: Gulsen
mesh_terms: D004396:Coloring Agents / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D004396:Coloring Agents