title: Genome sequence of herpes simplex virus 1 strain KOS.
abstract: Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is known to be less pathogenic than the first sequenced genome of HSV-1, strain 17. To understand the genotypic differences between KOS and other phenotypically distinct strains of HSV-1, we sequenced the viral genome of strain KOS. When comparing strain KOS to strain 17, there are at least 1,024 small nucleotide polymorphisms (SNPs) and 172 insertions/deletions (indels). The polymorphisms observed in the KOS genome will likely provide insights into the genes, their protein products, and the cis elements that regulate the biology of this HSV-1 strain.
authors.affiliation: Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA. sjmac@ku.edu
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Macdonald
authors.forename: Heba H
authors.initials: HH
authors.lastname: Mostafa
authors.forename: Lynda A
authors.initials: LA
authors.lastname: Morrison
authors.forename: David J
authors.initials: DJ
authors.lastname: Davido
mesh_terms: D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics*; D016679:Genome, Viral; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral