title: Romanian experience in child celiac disease diagnosis.
abstract: Last consensus in celiac disease in 2008 conducted under the aegis of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition jointly with North American Society of Pediatric Gastroenterology, Hepatology and Nutrition reveals the following: "celiac disease is a chronic immune-mediated enteropathy characterized by sensitization to gluten. That can affect any organ or system, with a wide range of clinical manifestations of variable severity". Thus, in recent years, clinical picture of celiac disease has changed the old paradigm--bowel disease with villous atrophy and malnutrition, being replaced with the new paradigm--multi-organ autoimmune disease, affecting many organs and systems throughout but with more less specific symptoms, which undiagnosed leads to delayed diagnosis, at a late-onset disease and long-term major complications as the risk of cancer. According to this consensus "the serological diagnosis of celiac disease is based on high sensitivity and specificity tests", but in line with changing clinical features of celiac disease, its diagnosis has undergone significant changes in recent years. These changes in the diagnosis of celiac disease, we have decided to analyze them.
authors.affiliation: Department of Immunology; "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. gabriel.samasca@umfcluj.ro
authors.forename: Gabriel
authors.initials: G
authors.lastname: Samaşca
authors.forename: Mihaela
authors.initials: M
authors.lastname: Iancu
authors.forename: Adrian
authors.initials: A
authors.lastname: Băican
authors.forename: Manuela
authors.initials: M
authors.lastname: Bruchental
authors.forename: Paraschiva
authors.initials: P
authors.lastname: Cherecheş-Panţa
authors.forename: Otilia
authors.initials: O
authors.lastname: Fufezan
authors.forename: Angela
authors.initials: A
authors.lastname: Butnariu
authors.forename: Dorin
authors.initials: D
authors.lastname: Farcău
authors.forename: Lucia
authors.initials: L
authors.lastname: Burac
authors.forename: Tudor
authors.initials: T
authors.lastname: Pop
authors.forename: Alexandru
authors.initials: A
authors.lastname: Pîrvan
authors.forename: Lucia
authors.initials: L
authors.lastname: Slăvescu
authors.forename: Nicolae
authors.initials: N
authors.lastname: Miu
authors.forename: Mariana
authors.initials: M
authors.lastname: Andreica
authors.forename: Doina
authors.initials: D
authors.lastname: Matinca
authors.forename: Dan
authors.initials: D
authors.lastname: Gheban
authors.forename: Romulus
authors.initials: R
authors.lastname: Nechit
authors.forename: Michaela
authors.initials: M
authors.lastname: Ponta
authors.forename: Ileana
authors.initials: I
authors.lastname: Constantinescu
authors.forename: Doru
authors.initials: D
authors.lastname: Dejica
authors.forename: Victor
authors.initials: V
authors.lastname: Cristea
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D003874:Dermatitis Herpetiformis / Q000175:diagnosis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D006650:Histocompatibility Testing; D006801:Humans; D012383:Romania; D012698:Serologic Tests