title: Altered long non-coding RNA expression profile in patients with IgA-negative             mesangial proliferative glomerulonephritis.
abstract: Mesangial proliferative glomerulonephritis (MsPGN) is one of the most common             immune-mediated renal diseases. The mesangium is expanded and hypercellular, immuno-globulin             deposits can be found in the mesangium, but the mechanism underlying its cause             remains largely unclear. There is a large amount of evidence suggesting that long             ﹥200 nucleotide) non-coding RNAs (lncRNA) have important regulatory functions             in the epigenetic control of gene expression. Multiple lines of evidence increasingly             link mutations and dysregulations of lncRNAs to a diverse number of human diseases.             Through microarray expression analysis, tests show that thousands of lncRNAs and             protein-coding genes are significantly differentially expressed in IgA-negative             MsPGN. Some lncRNAs and their neighboring protein-coding genes are closely related             and are cooperatively expressed. This may be part of a potential regulatory mechanism.             The malfunction of regulation in the network of lncRNAs may be a possible mechanism             for the development of IgA-negative MsPGN. Our observations suggest that some             lncRNAs are closely related to IgA-negative MsPGN and may be playing an important             role in this disease.
authors.affiliation: Nephrology Department, 181 Hospital, Guangxi Key Laboratory for                     Metabolic Diseases Research, Guilin 541002, Guangxi, P.R. China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Sui
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.forename: Minglin
authors.initials: M
authors.lastname: Ou
authors.forename: Dong'e
authors.initials: D
authors.lastname: Tang
authors.forename: Yong
authors.initials: Y
authors.lastname: Dai
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005786:Gene Expression Regulation; D005920:Glomerular Mesangium / Q000276:immunology / Q000473:pathology*; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D011401:Promoter Regions, Genetic; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D055815:Young Adult
chemical_list: D007070:Immunoglobulin A; D022661:RNA, Untranslated