title: Relationship between renal hemodynamics and urinary type IV collagen in patients with essential hypertension.
abstract: Urinary type IV collagen excretion (uT4C) in diabetic patients is higher than in normal subjects. In this study, we investigated the relationship between uT4C and renal hemodynamics in 42 patients with essential hypertension. The renal resistive index (RI) is calculated from blood flow velocities measured using pulsed-wave in interlobar arteries. There was a significant correlation between uT4C to creatinine ratio (uT4C/uCr) and age, hemoglobin A1c (HbA1c), and RI. A stepwise regression analysis showed that RI was independently associated with uT4C/uCr. These results indicated that uT4C may be a marker of renovascular stiffness due to glomerulosclerosis in patients with essential hypertension.
authors.affiliation: Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Japan.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Enomoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okura
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nagao
authors.forename: Masanori
authors.initials: M
authors.lastname: Jotoku
authors.forename: Jun
authors.initials: J
authors.lastname: Irita
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D024141:Collagen Type IV / Q000652:urine*; D003404:Creatinine / Q000652:urine; D003928:Diabetic Nephropathies / Q000150:complications; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology* / Q000652:urine*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications; D012307:Risk Factors; D014655:Vascular Resistance
chemical_list: D024141:Collagen Type IV; D003404:Creatinine