title: [Expression of PIM-1 in prostate cancer tissue and its relationship with PSA recurrence].
abstract: OBJECTIVE
  To explore the expression of the PIM-1 protein in prostate cancer tissue and its relationship with PSA recurrence.
  
  
  METHODS
  We used the immunohistochemical SP method to detect the expression of the PIM-1 protein in the prostate tissues of 68 cases of prostate cancer (PCa) and 37 cases of benign prostatic hyperplasia (BPH).
  
  
  RESULTS
  The positive rate of the PIM-1 protein expression was 67.65% (46/68) in the PCa tissue, significantly higher than 40.54% (15/37) in the BPH tissue (P<0.05). Its positive rates in PCa Gleason scores 6, 7 and 8-10 were 33.33% (7/21), 77.5% (21/28) and 94.74% (18/19), respectively, with significant between-group differences (P<0.05), and those in stages I , II, III and IV of PCa were 47.62%, 53.85%, 73.33% and 94.74%, respectively. Kaplan-Meier analysis of the results of a 36-month follow-up showed the ratios of PIM-1 expression to PSA recurrence and non-recurrence were 10/22 (45.45%) and 36/46 (78.26%), respectively, with statistically significant differences (P<0.05).
  
  
  CONCLUSIONS
  PIM-1 protein expression in PCa tissue is closely related to the Gleason score and clinical stage of PCa and PSA recurrence, which suggests that the PIM-1 gene plays an important role in PCa evolution and progression, and may be an indicator for the prognosis of PCa.
authors.affiliation: Department of Urology, The Second Hospital of Tianjin Medical University/Tianjin Research Institute of Urology, Tianjin 300211, China.
authors.forename: Chun-Ting
authors.initials: CT
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Luo
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Ran-Lu
authors.initials: RL
authors.lastname: Liu
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.forename: Bao-Jie
authors.initials: BJ
authors.lastname: Ma
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D051573:Proto-Oncogene Proteins c-pim-1 / Q000378:metabolism*
chemical_list: C496634:PIM1 protein, human; D051573:Proto-Oncogene Proteins c-pim-1