title: [Transgenic cell cultures that synthesize neurotrophic factors and the possibility of therapeutic use of its cells].
abstract: Under the leadership of Corresponding Member of the Russian Academy of Sciences L.I. Korochkin, the Laboratory of Neurogenetics and Developmental Genetics (Institute of Gene Biology, Russian Academy of Sciences) for many years has been conducting studies of nervous system development, neural cell differentiation, and application of gene and cell technology to cure neurodegenerative diseases. The results of the study initiated by L.I. Korochkin and continued by his scientific successors support the direction of allocation of transgenic neurotrofic factors and heat-shock proteins as neuroprotectors for cell therapy. Potential for usage of promoter of HSP70 heat-shock gene of Drosophila to create transgenic constructs for therapy has been shown. Further improvement of technology of nonvirus transfer for therapeutic genes, as well as production of multicomponent genetic constructs coding several therapeutic factors with synergy effect, would stimulate creation of efficient cell medicals to cure neurodegenerative diseases.
authors.forename: G V
authors.initials: GV
authors.lastname: Pavlova
authors.forename: N N
authors.initials: NN
authors.lastname: Kanaĭkina
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Panteleev
authors.forename: V E
authors.initials: VE
authors.lastname: Okhotin
authors.forename: A V
authors.initials: AV
authors.lastname: Revishchin
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018929:Cell Culture Techniques / Q000379:methods*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D008322:Mammals / Q000235:genetics; D009414:Nerve Growth Factors / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics / Q000628:therapy; D011401:Promoter Regions, Genetic
chemical_list: D029721:Drosophila Proteins; D051100:Glial Cell Line-Derived Neurotrophic Factor; D018840:HSP70 Heat-Shock Proteins; D009414:Nerve Growth Factors