title: Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging.
abstract: Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles that incorporate high payloads of nanocrystals into their core for tunable bioimaging features. We accomplished this through esterification reactions of PLGA to generate polymers modified with nanocrystals. The PLGA nanoparticles formed from modified PLGA polymers that were functionalized with either gold nanocrystals or quantum dots exhibited favorable features for computed tomography and optical imaging, respectively.
authors.affiliation: Translational and Molecular Imaging Institute and Imaging Science Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA.
authors.forename: Aneta J
authors.initials: AJ
authors.lastname: Mieszawska
authors.forename: Anita
authors.initials: A
authors.lastname: Gianella
authors.forename: David P
authors.initials: DP
authors.lastname: Cormode
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhao
authors.forename: Andries
authors.initials: A
authors.lastname: Meijerink
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
mesh_terms: D003952:Diagnostic Imaging; D005227:Fatty Acids / Q000737:chemistry*; D005233:Fatty Alcohols / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D011100:Polyglycolic Acid / Q000737:chemistry*; D045663:Quantum Dots; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: C505222:11-mercaptoundecanoic acid; C521238:11-mercaptoundecanol; D005227:Fatty Acids; D005233:Fatty Alcohols; D013438:Sulfhydryl Compounds; D011100:Polyglycolic Acid; D006046:Gold