title: GeVaDSs - decision support system for novel Genetic Vaccine development process.
abstract: BACKGROUND
  The lack of a uniform way for qualitative and quantitative evaluation of vaccine candidates under development led us to set up a standardized scheme for vaccine efficacy and safety evaluation. We developed and implemented molecular and immunology methods, and designed support tools for immunization data storage and analyses. Such collection can create a unique opportunity for immunologists to analyse data delivered from their laboratories.
  
  
  RESULTS
  We designed and implemented GeVaDSs (Genetic Vaccine Decision Support system) an interactive system for efficient storage, integration, retrieval and representation of data. Moreover, GeVaDSs allows for relevant association and interpretation of data, and thus for knowledge-based generation of testable hypotheses of vaccine responses.
  
  
  CONCLUSIONS
  GeVaDSs has been tested by several laboratories in Europe, and proved its usefulness in vaccine analysis. Case study of its application is presented in the additional files. The system is available at: http://gevads.cs.put.poznan.pl/preview/(login: viewer, password: password).
authors.affiliation: Institute of Computing Science, Poznań University of Technology, 60-965 Poznań, Poland. Pawel.Wojciechowski@cs.put.poznan.pl
authors.forename: Jacek
authors.initials: J
authors.lastname: Blazewicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Borowski
authors.forename: Wahiba
authors.initials: W
authors.lastname: Chaara
authors.forename: Pawel
authors.initials: P
authors.lastname: Kedziora
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.forename: Piotr
authors.initials: P
authors.lastname: Lukasiak
authors.forename: Adrien
authors.initials: A
authors.lastname: Six
authors.forename: Pawel
authors.initials: P
authors.lastname: Wojciechowski
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D003661:Decision Support Techniques; D015195:Drug Design; D004341:Drug Evaluation / Q000706:statistics & numerical data*; D005060:Europe; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods*; D012984:Software; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000706:statistics & numerical data; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D019444:Vaccines, DNA