title: Comparison between a guaiac and three immunochemical faecal occult blood tests in screening for colorectal cancer.
abstract: BACKGROUND
  The aim of this study was to compare the performance of the guaiac-based faecal occult blood test (G-FOBT), with that of three immunochemical faecal occult blood tests (I-FOBT) which allow automatic interpretation.
  
  
  METHODS
  Under the French organised screening programme, 85,149 average-risk individuals aged 50-74 participating in the third screening round, performed both the G-FOBT (Hemoccult-II test) and one of the I-FOBTs: FOB-Gold, Magstream and OC-Sensor.
  
  
  RESULTS
  Given the chosen threshold, the positivity ratio between the different I-FOBTs and the G-FOBT was 2.4 for FOB-Gold, 2.0 for Magstream and 2.2 for OC-Sensor (P=0.17). The three I-FOBTs were superior to the G-FOBT for colorectal cancer (CRC) detection. The ratios for detection rates were 1.6 (FOB-Gold), 1.7 (Magstream) and 2.1 (OC-Sensor) (P=0.74). For non-invasive CRC they were, respectively, 2.5, 3.0 and 4.0 (P=0.83) and for advanced adenomas 3.6, 3.1 and 4.0 (P=0.39).
  
  
  CONCLUSIONS
  This study provides further evidence that I-FOBT is superior to G-FOBT. None of the three I-FOBTs studied appeared to be significantly better than the others.
authors.affiliation: Registre Bourguignon des Cancers Digestifs, INSERM U866, Université de Bourgogne, CHU Dijon, 7 Boulevard Jeanne d'Arc, 21079 Dijon Cedex, France. jean.faivre@chu-dijon.fr
authors.forename: J
authors.initials: J
authors.lastname: Faivre
authors.forename: V
authors.initials: V
authors.lastname: Dancourt
authors.forename: B
authors.initials: B
authors.lastname: Denis
authors.forename: E
authors.initials: E
authors.lastname: Dorval
authors.forename: C
authors.initials: C
authors.lastname: Piette
authors.forename: Ph
authors.initials: P
authors.lastname: Perrin
authors.forename: J M
authors.initials: JM
authors.lastname: Bidan
authors.forename: C
authors.initials: C
authors.lastname: Jard
authors.forename: S
authors.initials: S
authors.lastname: Jung
authors.forename: R
authors.initials: R
authors.lastname: Levillain
authors.forename: J
authors.initials: J
authors.lastname: Viguier
authors.forename: J F
authors.initials: JF
authors.lastname: Bretagne
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000097:blood* / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D005243:Feces / Q000737:chemistry; D005260:Female; D005602:France; D006138:Guaiac; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009780:Occult Blood; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins; D006138:Guaiac