title: [Using of reamberin for correction of free radicals disturbances in patients with acute severe methadone poisonings].
abstract: The article deals with the materials, which have been received in the process of the examination and treatment of 44 patients with acute severe methadone poisonings.  It has been revealed, that gravity of these patient's condition depends on intensity of hypoxia due to breath deficiency because of the methadone. The development of hypoxia, in its turn, cause violations of antiradical protection system and intensification of processes of peroxide lipid oxidation. It has been registered that the including of reamberin into the complex program of the intensive therapy of acute severe methadone poisonings lead to a more rapid restoration of  antiradical protection system and to a decrease of  activity of processes of peroxide lipid oxidation. The correction of hypoxia and free-radical violations led to improvement of the acute poisonings clinic, what had been characterized by a decrease of coma-period duration, duration of treatment with artificial lung ventilation, a decrease of secondary lung complications and a decrease of lethality.
authors.forename: V V
authors.initials: VV
authors.lastname: Shilov
authors.forename: S A
authors.initials: SA
authors.lastname: Vasil'ev
authors.forename: B V
authors.initials: BV
authors.lastname: Batotsyrenov
authors.forename: A T
authors.initials: AT
authors.lastname: Loladze
authors.forename: O A
authors.initials: OA
authors.lastname: Kuznetsov
mesh_terms: D000328:Adult; D005260:Female; D005609:Free Radicals / Q000097:blood / Q000506:poisoning; D005978:Glutathione / Q000097:blood; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008691:Methadone / Q000097:blood / Q000506:poisoning*; D010100:Oxygen / Q000097:blood; D011041:Poisoning / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D020011:Protective Agents / Q000008:administration & dosage*; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D005609:Free Radicals; D020011:Protective Agents; C549374:Reamberin; D013386:Succinates; D008315:Malondialdehyde; D008536:Meglumine; D005978:Glutathione; D010100:Oxygen; D008691:Methadone