title: High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes.
abstract: BACKGROUND
  A higher prevalence of coronary heart disease (CHD) in people with diabetes. We investigated the high-density lipoprotein (HDL) subclass profiles and alterations of particle size in CHD patients with diabetes or without diabetes.
  
  
  METHODS
  Plasma HDL subclasses were quantified in CHD by 1-dimensional gel electrophoresis coupled with immunodetection.
  
  
  RESULTS
  Although the particle size of HDL tend to small, the mean levels of low density lipoprotein cholesterol(LDL-C) and total cholesterol (TC) have achieved normal or desirable for CHD patients with or without diabetes who administered statins therapy. Fasting plasma glucose (FPG), triglyceride (TG), TC, LDL-C concentrations, and HDL₃ (HDL(3b) and (3a)) contents along with Gensini Score were significantly higher; but those of HDL-C, HDL(2b+preβ2), and HDL(2a) were significantly lower in CHD patients with diabetes versus CHD patients without diabetes; The preβ₁-HDL contents did not differ significantly between these groups. Multivariate regression analysis revealed that Gensini Score was significantly and independently predicted by HDL(2a), and HDL(2b+preβ2).
  
  
  CONCLUSIONS
  The abnormality of HDL subpopulations distribution and particle size may contribute to CHD risk in diabetes patients. The HDL subclasses distribution may help in severity of coronary artery and risk stratification, especially in CHD patients with therapeutic LDL, TG and HDL levels.
authors.affiliation: Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Shiyin
authors.initials: S
authors.lastname: Long
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Li
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Liu
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.forename: Mingde
authors.initials: M
authors.lastname: Fu
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010316:Particle Size; D012044:Regression Analysis
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D008075:Lipoproteins, HDL