title: A hazardous link between malnutrition, inflammation and oxidative stress in renal patients.
abstract: BACKGROUND
  Atherosclerosis is the main cause of mortality in end stage renal disease (ESRD) patients.
  
  
  METHODS
  Malnutrition, inflammation and diminished paraoxonase activity were used to calculate the sum of risk factors for atherosclerosis development in a cohort of 141 chronic renal disease patients. Kaplan-Meier survival analysis was implemented to assess risk of death.
  
  
  RESULTS
  Kaplan-Meier analysis (Log rank=12.06, P=0.0072) showed higher risk of death with increasing number of risk factors in haemodialysis patients.
  
  
  CONCLUSIONS
  Malnutrition in combination with inflammation and oxidative stress is associated with higher mortality in patients on long-term haemodialysis.
authors.affiliation: Institute for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia. jkotur@pharmacy.bg.ac.rs
authors.forename: Jelena
authors.initials: J
authors.lastname: Kotur-Stevuljevic
authors.forename: Sanja
authors.initials: S
authors.lastname: Simic-Ogrizovic
authors.forename: Violeta
authors.initials: V
authors.lastname: Dopsaj
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stefanovic
authors.forename: Ana
authors.initials: A
authors.lastname: Vujovic
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ivanic-Corlomanovic
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasic
authors.forename: Vesna
authors.initials: V
authors.lastname: Kalimanovska-Spasojevic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelic-Ivanovic
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000401:mortality / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000209:etiology*; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D006435:Renal Dialysis
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human