title: Association of the DDAH2 gene polymorphism with type 2 diabetes and hypertension.
abstract: OBJECTIVE
  The aim of this study was to investigate whether the polymorphism of DDAH2 is associated with type 2 diabetes and hypertension in Korean population.
  
  
  METHODS
  Total 605 subjects were included in this study: 403 patients with type 2 diabetes and 202 non-diabetic control subjects. The SNP rs805304 and rs2272592 in DDAH2 were analyzed. We examined the association of SNP rs805304 and rs2272592 in DDAH2 with type 2 diabetes and hypertension.
  
  
  RESULTS
  SNP rs2272592 was significantly associated with type 2 diabetes (P<0.001) while SNP rs805304 was not (P=0.716). We observed that the prevalence of the AG+GG genotypes were significantly greater than AA homozygotes in type 2 diabetes (AA vs AG+GG; OR 20.74, 95% CI 6.48-66.35, P<0.001). Significance was maintained after adjusting for age, sex, BMI, DBP and BUN (OR 21.03, 95% CI 2.83-151.14, P=0.003). Both SNP rs805304 and rs2272592 in DDAH2 were not significantly associated with hypertension.
  
  
  CONCLUSIONS
  In the present study, we found that SNP rs2272592 in DDAH2 is associated with type 2 diabetes but SNP rs805304 in DDAH2 is not. DDAH2 SNP rs2272592 AG+GG genotypes are associated with genetic susceptibility to type 2 diabetes in Korean population.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Hyun-Ae
authors.initials: HA
authors.lastname: Seo
authors.forename: Su-Won
authors.initials: SW
authors.lastname: Kim
authors.forename: Eon-Ju
authors.initials: EJ
authors.lastname: Jeon
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Jeong
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Moon
authors.forename: Won-Kee
authors.initials: WK
authors.lastname: Lee
authors.forename: Jung-Guk
authors.initials: JG
authors.lastname: Kim
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Lee
authors.forename: Keun-Gyu
authors.initials: KG
authors.lastname: Park
mesh_terms: D000581:Amidohydrolases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D005215:Fasting / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D009569:Nitric Oxide; D000581:Amidohydrolases; C059999:dimethylargininase