title: Progressive multifocal leucoencephalopathy in a patient with idiopathic CD4+ lymphocytopenia.
abstract: Progressive multifocal leucoencephalopathy (PML) is an opportunistic, demyelinating neurological disease caused by reactivation of the JC polyomavirus. PML occurs almost exclusively in immunosuppressed individuals, with only isolated case reports of PML occurring in patients without apparent immunosuppression. Idiopathic CD4+ lymohocytopenia (ICL) is a syndrome defined by the Centre for Disease Control and Prevention as a CD4+ count <300 cells/uL or <20% of total T cell count on >1 occasion, with no evidence of human immunodeficiency virus (HIV) infection, and the absence of other known immunodeficiency or therapy associated with lymphocytopenia. We describe a case of PML occurring in a patient with idiopathic CD4+ lymphocytopenia.
authors.affiliation: Cork University Hospital, Wilton, Cork. fiachramoloney@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Moloney
authors.forename: D
authors.initials: D
authors.lastname: Fernandez
authors.forename: H
authors.initials: H
authors.lastname: Harrington
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000276:immunology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*