title: From modules to medicine: How modular domains and their associated networks can enable personalized medicine.
abstract: Unveiling of cancer genomes is unleashing new therapeutic strategies for cancer. With cancer parts lists in hand, new approaches to personalized medicine can be developed by understanding the assembly of cancer machines using modular domains in proteins and their associated networks. Using the Src-homology-2 (SH2) domain as an example, new profiling approaches can discern global patterns of tyrosine phosphorylation in cancer cells that can enable molecular cancer medicine. Identifying and quantifying protein-protein interactions also has the potential to subtype tumors and guide clinical decision making. These approaches should extend the impact of genomics through viewing the architecture of cancer systems and improve predictions of patient outcome and therapeutic response, as well as guide combination therapy approaches that attack cancer systems.
authors.affiliation: Department of Thoracic Oncology Program and Experimental Therapeutics Program, The H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Eric.Haura@moffitt.org
authors.forename: Eric B
authors.initials: EB
authors.lastname: Haura
mesh_terms: D000818:Animals; D023281:Genomics; D005838:Genotype; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000737:chemistry; D057285:Precision Medicine / Q000379:methods; D025941:Protein Interaction Mapping / Q000379:methods; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry; D011506:Proteins / Q000378:metabolism; D018909:src Homology Domains
chemical_list: D011506:Proteins; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases