title: Which cholinesterase inhibitor is the safest for the heart in elderly patients with Alzheimer's disease?
abstract: OBJECTIVE
  Cholinesterase inhibitors (ChEIs) are widely used for the treatment of Alzheimer's disease (AD); however, their cholinergic side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the side effects caused by donepezil, rivastigmine, and galantamine on cardiac rhythm and postural blood pressure changes in elderly patients with AD.
  
  
  METHODS
  Of 204 consecutive elderly patients who were newly diagnosed with AD, 162 were enrolled and underwent comprehensive geriatric assessments. The electrocardiographs (ECGs) and blood pressures were recorded at the baseline and 4 weeks after the dose of 10 mg/d of donepezil, 10 cm(2)/d of rivastigmine, and 24 mg/d of galantamine.
  
  
  RESULTS
  There were no changes relative to the baseline in any of the ECG parameters or arterial blood pressure with any of the administered ChEIs.
  
  
  CONCLUSIONS
  It was demonstrated that none of the 3 ChEIs were associated with increased negative chronotropic, arrhythmogenic, and hypotensive effects for the elderly patients with AD.
authors.affiliation: Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul, Turkey. atisik@yahoo.com
authors.forename: Ahmet Turan
authors.initials: AT
authors.lastname: Isik
authors.forename: Ergun
authors.initials: E
authors.lastname: Bozoglu
authors.forename: Adnan
authors.initials: A
authors.lastname: Yay
authors.forename: Pinar
authors.initials: P
authors.lastname: Soysal
authors.forename: Umit
authors.initials: U
authors.lastname: Ateskan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000077265:Donepezil; D005260:Female; D005702:Galantamine / Q000009:adverse effects* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007189:Indans / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D048448:Phenylcarbamates / Q000009:adverse effects* / Q000627:therapeutic use; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D000068836:Rivastigmine
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D048448:Phenylcarbamates; D010880:Piperidines; D005702:Galantamine; D000077265:Donepezil; D000068836:Rivastigmine