title: [Hepatocarcinogenesis in NASH].
abstract: With the increase of lifestyle-related diseases, metabolic syndrome has clearly increased in recent years. Fatty liver, which is the manifestation of metabolic syndrome in the liver, has received little attention because it is not the actual cause of death. However, with the developing increase of metabolic syndrome, non-alcoholic fatty liver disease(NAFLD), especially nonalcoholic steatohepatits(NASH), has increased, and has received much attention. In chronic liver disease, liver cirrhosis develops, finally leading to liver failure. The most serious chronic liver disease is progression to liver cancer. Once hepatic fibrosis develops, the hepatic carcinogenic rate has been increased. Hepatic carcinogenic rate has been reported to reach 8%per year in hepatitis type C-related liver cirrhosis. Although little has been reported about NASH-related liver cancer, NASH-related hepatic carcinogenic rate reached to about 2. 6%per year. In this review, we will describe the epidemiology, gender differences, risk factors and pathogenesis of NASH-related liver cancer.
authors.affiliation: Dept. of Gastroenterology, Aichi Medical University, Nagakute, Aichi, Japan.
authors.forename: Yukiomi
authors.initials: Y
authors.lastname: Nakade
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Nakao
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoneda
mesh_terms: D005234:Fatty Liver / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D065626:Non-alcoholic Fatty Liver Disease; D012307:Risk Factors; D012727:Sex Characteristics