title: Effects of subclinical hypothyroidism treatment on psychiatric symptoms, muscular complaints, and quality of life.
abstract: OBJECTIVE
  To evaluate the impact of subclinical hypothyroidism (sHT) treatment on health-related quality of life (QoL), psychiatric symptoms, clinical score, and muscle function.
  
  
  METHODS
  In this randomized double-blind study, patients were assigned either to treatment (n = 35) or placebo (n = 36). Clinical and psychiatric symptoms were assessed by the Zulewski, Hamilton and Beck scales. QoL was assessed by the SF-36 questionnaire. Assessments of quadriceps (QS) and inspiratory muscle (IS) strength were performed by a chair dynamometer and a manuvacuometer.
  
  
  RESULTS
  Treatment improved IS (+11.5 ± 17.2; p = 0.041), as did QoL domains "Pain" and "Role Physical" (+19.7 ± 15.2, 0.039 and +22.1 ± 47.5, p = 0.054; respectively). Clinical and psychiatric symptoms showed similar responses to both interventions.
  
  
  CONCLUSIONS
  sHT treatment improved IS and physical aspects of QoL, despite no impact in other muscle parameters. Clinical score, psychiatric symptoms, and SF-36 domains, based on mental dimensions of QoL may be more susceptible to "placebo effect" in patients with sHT.
authors.affiliation: School of Medicine, Universidade Federal do Rio de Janeiro, Brazil. vsreuters@hotmail.com
authors.forename: Vaneska Spinelli
authors.initials: VS
authors.lastname: Reuters
authors.forename: Cloyra de Paiva
authors.initials: Cde P
authors.lastname: Almeida
authors.forename: Patrícia de Fátima dos Santos
authors.initials: Pde F
authors.lastname: Teixeira
authors.forename: Patrícia dos Santos
authors.initials: Pdos S
authors.lastname: Vigário
authors.forename: Márcia Martins
authors.initials: MM
authors.lastname: Ferreira
authors.forename: Carmen Lucia Natividade de
authors.initials: CL
authors.lastname: Castro
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: Brasil
authors.forename: Antônio José Leal da
authors.initials: AJ
authors.lastname: Costa
authors.forename: Alexandru
authors.initials: A
authors.lastname: Buescu
authors.forename: Mário
authors.initials: M
authors.lastname: Vaisman
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D015990:Placebo Effect; D052097:Quadriceps Muscle / Q000187:drug effects / Q000503:physiopathology; D011788:Quality of Life; D012132:Respiratory Muscles / Q000187:drug effects / Q000503:physiopathology; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D013974:Thyroxine