title: Perspective: Dynamics of receptor tyrosine kinase signaling complexes.
abstract: Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing.
authors.affiliation: Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. bmayer@neuron.uchc.edu
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Mayer
mesh_terms: D000818:Animals; D002450:Cell Communication; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014443:Tyrosine / Q000737:chemistry; D018909:src Homology Domains
chemical_list: D008024:Ligands; D014443:Tyrosine; D020794:Receptor Protein-Tyrosine Kinases