title: Cardiac side effects of chemotherapy: state of art and strategies for a correct management.
abstract: In recent years, the development of more effective drugs has provided a better prognosis and an increase in life expectancy for patients at all-stages of cancer. On the other hand, the price for the improving effectiveness of therapies against malignant tumors is the development of severe and potentially life-threatening drug reactions. Among these, cardiac toxic effects have recently gained particular attention. The term cardiotoxicity includes many possible pathological manifestations, but the most frequent is the reduction in cardiac function, potentially leading to heart failure and death. Importantly, the development of cardiac dysfunction may occur immediately after drug administration, or after years. The purpose of this review is to discuss the clinical features of cardiotoxicity, its molecular basis and novel possible strategies to reduce the likelihood of serious cardiac complications.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Perrino
authors.forename: Gabriele G
authors.initials: GG
authors.lastname: Schiattarella
authors.forename: Fabio
authors.initials: F
authors.lastname: Magliulo
authors.forename: Federica
authors.initials: F
authors.lastname: Ilardi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carotenuto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gargiulo
authors.forename: Federica
authors.initials: F
authors.lastname: Serino
authors.forename: Marco
authors.initials: M
authors.lastname: Ferrone
authors.forename: Fernando
authors.initials: F
authors.lastname: Scudiero
authors.forename: Andreina
authors.initials: A
authors.lastname: Carbone
authors.forename: Bruno
authors.initials: B
authors.lastname: Trimarco
authors.affiliation: Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy. espogiov@unina.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Esposito
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004562:Electrocardiography; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents