title: Hba(1c) as a tool for the diagnosis of type 2 diabetes: comparison with fasting glucose.
abstract: BACKGROUND
  Glycated hemoglobin (HbA(1c)) has been proposed for the diagnosis of diabetes. However, several countries have not incorporated its use for this purpose yet and there is no consensus on a suitable cut-off point of HbA(1c) for the diagnosis of diabetes. Thus, the aim of this study was to evaluate the diagnostic characteristics of HbA(1c) and fasting plasma glucose (FPG) for the assessment of type 2 diabetes.
  
  
  METHODS
  FPG, HbA(1c), and creatinine levels were assessed in 47 patients with type 2 diabetes and 46 healthy controls.
  
  
  RESULTS
  The areas under the curve for HbA(1c) > or = 6.5% and FPG > or = 7.0 mmol/L were 0.97 and 0.92, respectively. HbA(1c). has a slightly higher ability to discriminate type 2 diabetes compared with FPG. The association between HbA(1c) and type 2 diabetes was independent of gender, age, hypertension, smoking, and body mass index.
  
  
  CONCLUSIONS
  HbA(1c) was able to be used for the diagnosis of type 2 diabetes.
authors.affiliation: Laboratório de Bioquímica Clínica, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Etiane
authors.initials: E
authors.lastname: Tatsch
authors.forename: Guilherme V
authors.initials: GV
authors.lastname: Bochi
authors.forename: Sílvia J
authors.initials: SJ
authors.lastname: Piva
authors.forename: Renata S
authors.initials: RS
authors.lastname: Pereira
authors.forename: Helena
authors.initials: H
authors.lastname: Kober
authors.forename: José Antônio M
authors.initials: JA
authors.lastname: De Carvalho
authors.forename: Manuela B
authors.initials: MB
authors.lastname: Sangoi
authors.forename: Marta M M F
authors.initials: MM
authors.lastname: Duarte
authors.forename: Rafael N
authors.initials: RN
authors.lastname: Moresco
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012015:Reference Standards
chemical_list: D015415:Biomarkers; D003404:Creatinine; D006442:Glycated Hemoglobin