title: Congenital transmission of experimental leishmaniasis in a hamster model.
abstract: Little information is available on transplacental transmission of Leishmania spp. We determined the frequency and impact of congenital infection caused by Leishmania panamensis or L. donovani in experimentally infected hamsters. A polymerase chain reaction showed that congenital transmission occurred in 25.8% (24 of 93) of offspring born to L. panamensis-infected hamsters and 14.6% (11 of 75) offspring born to L. donovani-infected hamsters. Mortality during lactation was higher in offspring born to L. panamensis-infected hamsters and offspring born to L. donovani-infected hamsters than controls, and lymphoproliferation to Leishmania was more frequent in offspring born to L. panamensis-infected hamsters (17.4%, 11 of 63) than in offspring born to L. donovani-infected hamsters (8.5%, 3 of 35). After weaning, only offspring born to L. donovani-infected hamsters had lower weight gain (P < 0.001) and hematocrit levels (P = 0.0045) than controls. Challenge of offspring born to L. panamensis-infected hamsters with L. panamensis showed no differences in lesion evolution, and offspring born to L. donovani-infected hamsters were more susceptible to L. donovani challenge than controls. Consequently, prenatal exposure of hamsters to L. donovani significantly increased the mortality risk and susceptibility to secondary homologous infection.
authors.affiliation: Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555, USA. ejosorio@utmb.edu
authors.forename: Yaneth
authors.initials: Y
authors.lastname: Osorio
authors.forename: Luz D
authors.initials: LD
authors.lastname: Rodriguez
authors.forename: Diana L
authors.initials: DL
authors.lastname: Bonilla
authors.forename: Alex G
authors.initials: AG
authors.lastname: Peniche
authors.forename: Hector
authors.initials: H
authors.lastname: Henao
authors.forename: Omar
authors.initials: O
authors.lastname: Saldarriaga
authors.forename: Bruno L
authors.initials: BL
authors.lastname: Travi
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D007109:Immunity; D018445:Infectious Disease Transmission, Vertical; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000473:pathology / Q000635:transmission*; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology / Q000469:parasitology; D060888:Real-Time Polymerase Chain Reaction; D013154:Spleen / Q000469:parasitology / Q000473:pathology