title: Role of enhanced visibility in evaluating polyposis syndromes using a newly developed contrast image capsule endoscope.
abstract: OBJECTIVE
  A flexible spectral imaging color enhancement system was installed in new capsule software for video capsule endoscopy. Contrast image capsule endoscopy (CICE) is a novel technology using light-emitting diodes selected for the main absorption range of hemoglobin. We assessed the feasibility and diagnostic effi cacy for small bowel surveillance in patients with polyposis syndromes.
  
  
  METHODS
  Six patients with polyposis syndromes, four with familial adenomatous polyposis and one each with Cowden syndrome (CS) and Cronkhite-Canada syndrome (CCS) were examined using CICE. We conducted three evaluations to assess the effect on the numbers of the detected polyps; compare polyp diagnostic rates between adenoma and hamartoma; and assess polyp visibility.
  
  
  RESULTS
  The numbers of detected polyps and diagnostic accuracy did not differ signifi cantly between pre-contrast and contrast images. However, 50% of the adenomatous polyps displayed enhanced visibility on contrast images. CICE contrast images exhibited clearly demarcated lesions and improved the visibility of minute structures of adenomatous polyps. Hamartomatous polyp micro-structures in patients with CS and CCS were more clearly visualized on contrast than pre-contrast images.
  
  
  CONCLUSIONS
  CICE is an effective tool for enhancing the visibility of polyps in patients with polyposis syndrome.
authors.affiliation: Tokyo Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Hatogai
authors.forename: Naoki
authors.initials: N
authors.lastname: Hosoe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imaeda
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Rey
authors.forename: Sawako
authors.initials: S
authors.lastname: Okada
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Kayoko
authors.initials: K
authors.lastname: Kimura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yoneno
authors.forename: Shingo
authors.initials: S
authors.lastname: Usui
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ida
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
authors.forename: Takanori
authors.initials: T
authors.lastname: Kanai
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ogata