title: Pharmacokinetics of intraperitoneal and intravenous fosfomycin in automated peritoneal dialysis patients without peritonitis.
abstract: Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intraperitoneal administration) and 0.22 (intravenous administration), indicating good systemic exposure after intraperitoneal application but limited penetration of fosfomycin into the peritoneal fluid after the intravenous dose.
authors.affiliation: Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Selma
authors.initials: S
authors.lastname: Tobudic
authors.forename: Peter
authors.initials: P
authors.lastname: Matzneller
authors.forename: Brigitte
authors.initials: B
authors.lastname: Stoiser
authors.forename: Judith Maria
authors.initials: JM
authors.lastname: Wenisch
authors.forename: Markus
authors.initials: M
authors.lastname: Zeitlinger
authors.forename: Andreas
authors.initials: A
authors.lastname: Vychytil
authors.forename: Walter
authors.initials: W
authors.lastname: Jaeger
authors.forename: Michaela
authors.initials: M
authors.lastname: Boehmdorfer
authors.forename: Gottfried
authors.initials: G
authors.lastname: Reznicek
authors.forename: Heinz
authors.initials: H
authors.lastname: Burgmann
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010538:Peritonitis
chemical_list: D005578:Fosfomycin