title: Citrus flavanones: what is their role in cardiovascular protection?
abstract: Flavanones, including hesperidin and naringin, are polyphenolic compounds highly and almost exclusively present in citrus. Epidemiological studies reported an inverse relationship between their intake and the risk of cardiovascular diseases. Clinical and experimental data further showed their antihypertensive, lipid-lowering, insulin-sensitizing, antioxidative, and anti-inflammatory properties, which could explain their antiatherogenic action in animal models. Although flavanones may be promising compounds that are particularly active in cardiovascular disease prevention, clinical data are still scarce and most in vitro data have been obtained under nonphysiologically relevant conditions. Moreover, the mechanisms responsible for flavanone action are not fully elucidated. Therefore, further research is needed to better evaluate and understand the protective effects of flavanones in cardiovascular diseases.
authors.affiliation: INRA , UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Chanet
authors.forename: Dragan
authors.initials: D
authors.lastname: Milenkovic
authors.forename: Claudine
authors.initials: C
authors.lastname: Manach
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mazur
authors.forename: Christine
authors.initials: C
authors.lastname: Morand
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D002957:Citrus / Q000737:chemistry*; D044950:Flavanones / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D044950:Flavanones; D010936:Plant Extracts; C028610:flavanone