title: Histologic evaluation of an allogeneic mineralized bone matrix in the treatment of periodontal osseous defects.
abstract: The aim of this study was to evaluate the potential of an allogeneic bone matrix to regenerate new bone, cementum, and periodontal ligament around a previously diseased root surface. Four patients with severe chronic periodontitis and teeth with hopeless periodontal or restorative prognoses participated in this study. One tooth with a severe intraosseous defect was selected per patient. At baseline, measurements of probing depth, gingival recession, and clinical attachment level were obtained. Following flap reflection, a root notch was placed at the apical extent of the calculus; the root was debrided, and the allogeneic bone graft material was placed into the defect. After a minimum of 6 months of healing, the teeth were removed en bloc and prepared for histologic examination. Two of four teeth demonstrated regeneration of new bone, cementum, and periodontal ligament. One tooth healed by new connective tissue attachment, and another by junctional epthelium.
authors.forename: Jana-Marie
authors.initials: JM
authors.lastname: Koylass
authors.forename: Pilar
authors.initials: P
authors.lastname: Valderrama
authors.forename: James T
authors.initials: JT
authors.lastname: Mellonig
mesh_terms: D016301:Alveolar Bone Loss / Q000145:classification / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D001857:Bone Matrix / Q000473:pathology / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D055113:Chronic Periodontitis / Q000601:surgery*; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D012534:Dental Scaling / Q000379:methods; D004846:Epithelial Attachment / Q000473:pathology; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000145:classification / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010513:Periodontal Ligament / Q000473:pathology; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D016745:Root Planing / Q000379:methods; D013524:Surgical Flaps; D019237:Tooth Cervix / Q000473:pathology; D014092:Tooth Root / Q000473:pathology; D014184:Transplantation, Homologous