title: Targeting NADPH oxidases for the treatment of cancer and inflammation.
abstract: NADPH oxidases are a family of oxidases that utilize molecular oxygen to generate hydrogen peroxide and superoxide, thus indicating physiological functions of these highly reactive and short-lived species. The regulation of these NADPH oxidases (nox) enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. While the complexity of the nox family (Nox1-5, Duox1, 2) is daunting, the complexity also allows for targeting of NADPH oxidases in disease states. In this review, we discuss which inflammatory and malignant disorders can be targeted by nox inhibitors, as well as clinical experience in the use of such inhibitors.
authors.affiliation: Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Bonner
authors.forename: Jack L
authors.initials: JL
authors.lastname: Arbiser
mesh_terms: D000465:Algorithms; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000628:therapy*; D000074624:NADPH Oxidase 1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D000074624:NADPH Oxidase 1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C402799:NOX1 protein, human; C498910:NOX4 protein, human