title: Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers.
abstract: Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC(50) values between 31.25-473.59 µM. Compounds 8, 2, and 10 have IC(50) values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 µM, respectively. Standard npropylgallate showed an IC(50) value 30.12 ± 0.27 µM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC(50) values in the range of 175.6-450.89 µM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC(50) = 106.34 ± 1.6 µM).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Farzana
authors.initials: F
authors.lastname: Naz
authors.forename: Salman
authors.initials: S
authors.lastname: Siddiqui
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.forename: Fazal
authors.initials: F
authors.lastname: Rahim
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D012545:Schiff Bases; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl