title: Retinoids: novel immunomodulators and tumour-suppressive agents?
abstract: Retinoids play important roles in the transcriptional activity of normal, degenerative and tumour cells. Retinoid analogues may be promising therapeutic agents for the treatment of immune disorders as different as type I diabetes and systemic lupus erythematosus. In addition, the use of retinoids in cancer treatment has progressed significantly in the last two decades; thus, numerous retinoid compounds have been synthesized and tested. In this paper, the actual or potential use of retinoids as immunomodulators or tumour-suppressive agents is discussed.
authors.affiliation: Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Carratù
authors.forename: C
authors.initials: C
authors.lastname: Marasco
authors.forename: G
authors.initials: G
authors.lastname: Mangialardi
authors.forename: A
authors.initials: A
authors.lastname: Vacca
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy / Q000503:physiopathology; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D012176:Retinoids / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D012176:Retinoids