title: Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.
abstract: Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."
authors.affiliation: Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA. malewis@mednet.ucla.edu
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Lewis
authors.forename: Mirabelle
authors.initials: M
authors.lastname: Dagarag
authors.forename: Basim
authors.initials: B
authors.lastname: Khan
authors.forename: Ayub
authors.initials: A
authors.lastname: Ali
authors.forename: Otto O
authors.initials: OO
authors.lastname: Yang
mesh_terms: D019943:Amino Acid Substitution; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D057131:Immune Evasion; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D012367:RNA, Viral