title: Effect of alloxan time administerDrug on establishing diabetic rabbit model.
abstract: OBJECTIVE
  To explore the effect of alloxan time administerDrug on establishing diabetic rabbit model.
  
  
  METHODS
  Thirty-six healthy rabbits, weighed 2-2.5kg, were randomly divided into one time administerDrug group (Group A, n=12), two times administerDrug group (Group B, n=12) and three times administerDrug group(Group C, n=12). Every rabbit was injected with alloxan of 150mg/kg. The three groups were measured for fasting blood-glucose. The success rate and death rate of each group were also calculated.
  
  
  RESULTS
  The success rate of diabetic rabbit model in Group B was higher than that in Group A (P<0.01) but its death rate was lower than that of Group A (P<0.01); the success rate of diabetic rabbit model in Group C was highest but the death rate was the lowest in the three groups.
  
  
  CONCLUSIONS
  Separate administration of alloxan can improve success rate in establishing diabetic rabbit model, decrease the death rate and keep the stability of model.
authors.affiliation: Department of Ophthalmology, Xi'an No.4 Hospital, Xi'an 710004, Shaanxi Province, China.
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Sun
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Lei
authors.forename: Chun-Chao
authors.initials: CC
authors.lastname: Bi
authors.forename: Zheng-Lan
authors.initials: ZL
authors.lastname: Chen
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang