title: Butanolide derivatives from the bark of Machilus yaoshansis.
abstract: Six new butanolide derivatives with long aliphatic side chains (1-6), together with 23 known lipophilic constituents, were isolated from the bark of Machilus yaoshansis. Their structures were elucidated by spectroscopic and chemical methods. All the isolates were evaluated for cytotoxic and anti-inflammatory activities.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Ming-Tao
authors.initials: MT
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Mao-Luo
authors.initials: ML
authors.lastname: Gan
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Jia-Chen
authors.initials: JC
authors.lastname: Zi
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Song
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Fan
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Tan
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D015107:4-Butyrolactone