title: Re-irradiation: outcome, cumulative dose and toxicity in patients retreated with stereotactic radiotherapy in the abdominal or pelvic region.
abstract: The purpose of the present study was to explore the outcome, cumulative dose in tumor and organs at risk and toxicity after extra-cranial stereotactic re-irradiation. Twenty-seven patients were evaluated who had been re-irradiated with stereotactic body radiotherapy (SBRT) after conventional radiotherapy (CRT). The dose summation of the SBRT and CRT plans was done by dose point calculations accounting for fraction size by the linear-quadratic model. Efficacy and toxicity was scored by looking at the reduction in tumor size, pain and bleeding. Symptomatic response was observed in 96% of the patients. The median maximum SBRT dose to the tumor was 90 Gy(3) (range: 42-420 Gy(3)). The median cumulative dose for the rectum, bowel and bladder resulted in 104 Gy(3), 98 Gy(3) and 113 Gy(3), respectively. No grades 5, 4 and 3 acute and late toxicity was observed.
  
  
  CONCLUSIONS
  re-irradiation to the same region using extra-cranial stereotactic radiotherapy is feasible and resulted in a 96% symptomatic response with low toxicity.
authors.affiliation: Department of Radiation Oncology, Erasmus MC- Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. h.abusaris@erasmusmc.nl
authors.forename: Huda
authors.initials: H
authors.lastname: Abusaris
authors.forename: M
authors.initials: M
authors.lastname: Hoogeman
authors.forename: Joost J
authors.initials: JJ
authors.lastname: Nuyttens
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000528:radiation effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality / Q000601:surgery*; D010388:Pelvis / Q000473:pathology / Q000528:radiation effects*; D016634:Radiosurgery / Q000009:adverse effects; D011879:Radiotherapy Dosage; D019233:Retreatment; D016896:Treatment Outcome