title: A history of comorbid depression and anxiety predicts new onset of heart disease.
abstract: The objective of the current study was to examine whether a history of comorbid depression and anxiety predicted new onset of heart disease. Data from 6 surveys, spanning 15 years, of the Australian Longitudinal Study on Women's Health, a large prospective cohort study were used, including health status, lifestyle, and sociodemographic measures. Participants of the 1946-1951 cohort who did not self-report heart disease at surveys 1 (1996) and 2 (1998) were included in the study (n = 11,828). After adjusting for health status, lifestyle and sociodemographic factors, a history of comorbid depression and anxiety (odds ratio (OR) = 1.78; 95 % confidence interval (CI) = 1.41-2.24) was associated with new onset of heart disease. A history of comorbid depression and anxiety is an important predictor of new onset of heart disease in mid-aged women. Due to the possible detrimental consequences of heart disease, psychological factors as well as established predictors should be considered when assessing a person's risk for heart disease.
authors.affiliation: School of Population Health, The University of Queensland, Herston Road, Herston, QLD, 4006, Australia.
authors.forename: Janneke
authors.initials: J
authors.lastname: Berecki-Gisolf
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: McKenzie
authors.forename: Annette J
authors.initials: AJ
authors.lastname: Dobson
authors.forename: Alexander
authors.initials: A
authors.lastname: McFarlane
authors.forename: Deirdre
authors.initials: D
authors.lastname: McLaughlin
mesh_terms: D001007:Anxiety / Q000453:epidemiology*; D001315:Australia / Q000453:epidemiology; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016387:Women's Health / Q000706:statistics & numerical data