title: Impact of changes in extracellular matrix in the lumbar degenerative disc.
abstract: The complexity of the clinical, biochemical, hystochemical and immunologic aspects of the intervertebral disk, along with its molecular biology, justifies the object of our study on the extracellular matrix modifications in lumbar disk hernias and their impact on patient quality of life.
  
  
  METHODS
  The research lot was composed of 50 patients, aged between 18 and 73, who have undergone lumbar disk hernia surgery. MMP-9 (metalloproteinase-9) and TIMP-1 (tissue inhibitor of matrix metalloprotease 1) have been dosed in order to study the modifications on extracellular disk matrix, and quality of life assessment was carried out both in pre-operatory and post-operatory periods.
  
  
  CONCLUSIONS
  Patients may prevent the appearance of degenerative processes of the intervertebral disk with care and responsibility by controlling their weight, avoiding intense physical activities and ceasing to smoke.
authors.affiliation: Regina Maria Military Hospital, Neurosurgery Clinic, Brașov, Romania. david_nch@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: David
authors.forename: A V
authors.initials: AV
authors.lastname: Ciurea
authors.forename: M
authors.initials: M
authors.lastname: Mitrica
authors.forename: A
authors.initials: A
authors.lastname: Mohan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005109:Extracellular Matrix / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007403:Intervertebral Disc / Q000201:enzymology / Q000473:pathology*; D055959:Intervertebral Disc Degeneration / Q000201:enzymology / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000201:enzymology / Q000473:pathology*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D011788:Quality of Life; D012307:Risk Factors; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D055815:Young Adult
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9