title: Human papillomavirus is associated with breast cancer in the north part of Iran.
abstract: We have analyzed the possible relevance of HPV infection for breast cancer risk among Iranian women from north part of Iran. Among women with breast cancer, 25.9% had positive test results for HPV DNA in breast tumor samples in contrast to 2.4% of women with noncancer status (P = 0.002). The infection of HPV has increased the risk of breast cancer (OR 14.247; 95% CI 1.558-130.284, P = 0.019). The high-risk HPV genotypes (types 16 and 18) in samples of breast cancer patients were the predominant types (53.34%). Other genotypes detected in breast cancer were HPV-6, HPV-11, HPV-15, HPV-23, and HPV-124, and one isolate could not be genotyped compared to HPV reference sequences. While the sole detected HPV in control specimens was HPV-124. Our study reveals that HPV infection and age are the risk factors in breast cancer development in the north part of Iran.
authors.affiliation: Department of Biology, Science and Research Center, Islamic Azad University, Hesarak, Ashrafi Esfahani Highway, Tehran 14778-93855, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Sigaroodi
authors.forename: Seyed Alireza
authors.initials: SA
authors.lastname: Nadji
authors.forename: Farshad
authors.initials: F
authors.lastname: Naghshvar
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
authors.forename: Habib
authors.initials: H
authors.lastname: Emami
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Velayati
mesh_terms: D000328:Adult; D000367:Age Factors; D001483:Base Sequence; D001943:Breast Neoplasms / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005814:Genes, Viral; D005838:Genotype; D052162:Human papillomavirus 16 / Q000235:genetics* / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D015995:Prevalence; D012307:Risk Factors
chemical_list: D004279:DNA, Viral