title: Association between interleukin-6 gene -174 G/C polymorphism and the risk of coronary heart disease: a meta-analysis of 20 studies including 9619 cases and 10,919 controls.
abstract: Interleukin-6 (IL-6) gene -174 G/C polymorphism has been reported to be associated with coronary heart disease (CHD), but the results remain inconclusive. The present meta-analysis was therefore designed to clarify these controversies. This meta-analysis was performed by searching PubMed, Embase and Web of Science databases. A total of 20 studies including 9619 CHD cases and 10,919 controls were combined showing no evidence of association between IL-6 gene -174 G/C polymorphism and CHD risk (for C/C+C/G vs. G/G: OR=1.10, 95% CI=0.99-1.22, p=0.07; for C/C vs. C/G+G/G: OR=1.08, 95% CI=0.93-1.24, p=0.33; for C/C vs. G/G: OR=1.16, 95% CI=0.97-1.39, p=0.11; for C allele vs. G allele: OR=1.10, 95% CI=1.00-1.21, p=0.06). Moreover, we also did not find significant association between IL-6 gene -174 G/C polymorphism and myocardial infarction (MI) risk. However, in the subgroup analysis by ethnicity, significant association was found among Asians (for C/C+C/G vs. G/G: OR=1.35, 95% CI=1.05-1.63, p=0.02). In summary, the present meta-analysis suggests that IL-6 gene -174 G/C polymorphism is associated with increased CHD risk among Asians. However, due to the small subjects included in the subgroup analysis of Asians, the results should be interpreted with caution.
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, Beijing, China. shuaishuaijita@sohu.com
authors.forename: Yan-wei
authors.initials: YW
authors.lastname: Yin
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Hu
authors.forename: Qian-qian
authors.initials: QQ
authors.lastname: Sun
authors.forename: Hong-li
authors.initials: HL
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Yi-hua
authors.initials: YH
authors.lastname: Zeng
authors.forename: Rui-jia
authors.initials: RJ
authors.lastname: Xu
authors.forename: Zhi-zhen
authors.initials: ZZ
authors.lastname: Hou
authors.forename: Zhong-dong
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Ming-qi
authors.initials: MQ
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics; D011110:Polymorphism, Genetic; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6