title: Synthesis, characterization and evaluation of benzylidene analogues as a new class of potential antioxidant agents.
abstract: Seventeen analogues of benzylidene were synthesized and evaluated for in vitro hydrogen peroxide scavenging activity. The structure of the newly synthesized compounds were confirmed by elemental and spectral (IR, 1H-NMR, 13C-NMR) studies. The antioxidant activity of the titled compounds was evaluated. Compounds: 4h--N'-[2-amino-3-(morpholinomethyl)benzylidene]isonicotinohydrazide, 4p 7-(4-(2-amino-3-[(2-isonicotinoylhydrazono)methyl]benzyl}piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquino- line-3-carboxylic acid and 4q 7-(4-{2-amino-3-[(2 isonicotinoylhydrazono)methyl]benzyl} piperazin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid were the most active compounds with significant hydrogen peroxide scavenging activity.
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozepur Road, Moga-142 001, India.
authors.forename: Manav
authors.initials: M
authors.lastname: Malhotra
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sharma
authors.forename: Mohit
authors.initials: M
authors.lastname: Sanduja
authors.forename: Pankhuri
authors.initials: P
authors.lastname: Hans
authors.forename: Sagun
authors.initials: S
authors.lastname: Sharma
authors.forename: Aakash
authors.initials: A
authors.lastname: Deep
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000975:Antioxidants; D001597:Benzylidene Compounds