title: A facile one-pot process for the formation of hindered tertiary amines.
abstract: A simple and convenient method was developed for the preparation of hindered tertiary amines via direct reductive amination of ketones with secondary aryl amines, using trichlorosilane as reducing agent and tetramethylethylenediamine (TMEDA) as organic Lewis base activator. A broad range of ketones were reacted with N-methylaniline to afford the corresponding tertiary amine products in high yield. An open transition model was proposed for the reductive step.
authors.affiliation: Department of Pharmaceutics Engineering, Xihua University, Chengdu 610039, China. zhouyuwang77@gmail.com
authors.forename: Zhouyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Pei
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D005029:Ethylenediamines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000814:Aniline Compounds; D005029:Ethylenediamines; D007659:Ketones; D012821:Silanes; C005798:N,N,N',N'-tetramethylethylenediamine; C065893:trichlorosilane; C021313:methylaniline