title: Bahamaolides A and B, antifungal polyene polyol macrolides from the marine actinomycete Streptomyces sp.
abstract: Bahamaolides A and B (1 and 2), two new 36-membered macrocyclic lactones, were isolated from the culture of the marine actinomycete Streptomyces sp. derived from a sediment sample collected at North Cat Cay in the Bahamas. The planar structures of 1 and 2, bearing a hexaenone and nine consecutive skipped hydroxy groups, were determined by 1D and 2D NMR, mass, IR, and UV spectra. The absolute configurations of the bahamaolides were established by combined multistep chemical reactions and spectroscopic analysis. Bahamaolide A displayed significant inhibitory activity against Candida albicans isocitrate lyase and antifungal activity against various pathogenic fungi.
authors.affiliation: Natural Products Research Institute, College of Pharmacy,  Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Dong-Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Kyuho
authors.initials: K
authors.lastname: Moon
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Seon-Hui
authors.initials: SH
authors.lastname: Park
authors.forename: Sunghyouk
authors.initials: S
authors.lastname: Park
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001444:Bahamas; D002176:Candida albicans / Q000201:enzymology; D005658:Fungi / Q000187:drug effects; D007522:Isocitrate Lyase / Q000187:drug effects / Q000378:metabolism; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D018942:Macrolides; D011090:Polyenes; C574270:bahamaolide A; C574271:bahamaolide B; D007522:Isocitrate Lyase