title: Salicylic-acid derivatives as antennae for ratiometric luminescent probes based on lanthanide complexes.
abstract: Long-lived ratiometric sensors: Luminescent lanthanide complexes are widely used in time-resolved assays of biomolecules, but most of the sensors with these complexes rely on single-point intensity measurements. Herein, we introduce a simple strategy to create ratiometric probes by using salicylic-acid derivatives as the antenna moiety of Tb(3+) complexes. As an example, a probe for alkaline phosphatase (ALP) was developed (see scheme).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 1130033, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Terai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ito
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nagano
mesh_terms: D005456:Fluorescent Dyes; D006867:Hydrolases / Q000378:metabolism; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049449:Luminescence; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry*; D013725:Terbium / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D012459:Salicylates; D013725:Terbium; D006867:Hydrolases