title: Session III: Mechanisms of age-related cognitive change and targets for intervention: inflammatory, oxidative, and metabolic processes.
abstract: There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Washington, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Seattle, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Craft
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Foster
authors.forename: Philip W
authors.initials: PW
authors.lastname: Landfield
authors.forename: Steven F
authors.initials: SF
authors.lastname: Maier
authors.forename: Susan M
authors.initials: SM
authors.lastname: Resnick
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology / Q000523:psychology*; D000818:Animals; D001921:Brain / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007328:Insulin / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications*; D017628:Microglia / Q000502:physiology; D018384:Oxidative Stress; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
chemical_list: D007328:Insulin; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium