title: Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives.
abstract: In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD(50)). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD(50) and pharmacological activities of the synthesized compounds were reported.
authors.affiliation: Pharmacy Department, College of Medical Rehabilitation Sciences, Taibah University, Madinah Munawara, Saudi Arabia. drsalehamb@yahoo.com
authors.forename: Saleh A
authors.initials: SA
authors.lastname: Bahashwan
authors.forename: Naif O
authors.initials: NO
authors.lastname: Al-Harbi
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Fayed
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
authors.forename: Khalid A
authors.initials: KA
authors.lastname: Shadid
authors.forename: Ali M
authors.initials: AM
authors.lastname: Alalawi
authors.forename: Ibrahim M S
authors.initials: IM
authors.lastname: Bassati
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D011724:Pyridazines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006571:Heterocyclic Compounds; D011083:Polycyclic Compounds; D011724:Pyridazines