title: Optimisation of nasal swab analysis by liquid scintillation counting.
abstract: When responding to an emergency radiological incident, rapid methods are needed to provide the physicians and radiation protection personnel with an early estimation of possible internal dose resulting from the inhalation of radionuclides. This information is needed so that appropriate medical treatment and radiological protection control procedures can be implemented. Nasal swab analysis, which employs swabs swiped inside a nostril followed by liquid scintillation counting of alpha and beta activity on the swab, could provide valuable information to quickly identify contamination of the affected population. In this study, various parameters (such as alpha/beta discrimination, swab materials, counting time and volume of scintillation cocktail etc) were evaluated in order to optimise the effectiveness of the nasal swab analysis method. An improved nasal swab procedure was developed by replacing cotton swabs with polyurethane-tipped swabs. Liquid scintillation counting was performed using a Hidex 300SL counter with alpha/beta pulse shape discrimination capability. Results show that the new method is more reliable than existing methods using cotton swabs and effectively meets the analysis requirements for screening personnel in an emergency situation. This swab analysis procedure is also applicable to wipe tests of surface contamination to minimise the source self-absorption effect on liquid scintillation counting.
authors.affiliation: AECL Chalk River Nuclear Laboratory, Chalk River, ON K0J 1J0, Canada. daix@aecl.ca
authors.forename: Xiongxin
authors.initials: X
authors.lastname: Dai
authors.forename: Aaron
authors.initials: A
authors.lastname: Liblong
authors.forename: Sheila
authors.initials: S
authors.lastname: Kramer-Tremblay
authors.forename: Nicholas
authors.initials: N
authors.lastname: Priest
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Li
mesh_terms: D000396:Air Pollutants, Radioactive / Q000032:analysis*; D001681:Biological Assay / Q000379:methods*; D006801:Humans; D009297:Nasal Mucosa / Q000737:chemistry*; D011834:Radiation Monitoring / Q000379:methods*; D011868:Radioisotopes / Q000032:analysis*; D015203:Reproducibility of Results; D012588:Scintillation Counting / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D000396:Air Pollutants, Radioactive; D011868:Radioisotopes