title: [Study on pharmacokinetics of danshensu sodium in danshen dripping solution in Beagles].
abstract: OBJECTIVE
  To detect pharmacokinetics of Danshensu Sodium in Danshen dripping solution in Beagles.
  
  
  METHODS
  Danshen dripping solution was dripped intravenously into healthy Beagles at a dose of 10 mL x kg(-1). Their plasma samples were extracted with acetic ether, the blood concentrations were determined by HPLC method.
  
  
  RESULTS
  Danshensu Sodium showed a good linear relationship within the range of 0.225-18.000 mg x L(-1), with the lowest detectable limit of 0.113 mg x L(-1). Its pharmacokinetic parameters were as follows: tmax was 30 min, Cmax was (9.5742 +/- 2.3715) mg x L(-1), t1/2 was (19.23 +/- 2.97) min, CL was (0.0127 +/- 0.0030) L x min(-1) x kg(-1), AUC(0-tn) was (474.954 +/- 95.483) mg x min x L(-1) and AUC(0-infinity) was (482.494 +/- 95.353) mg x min x L(-1).
  
  
  CONCLUSIONS
  The accurate, stable and reliable blood concentration method shows a one-compartment mode of Danshensu Sodium in Beagles.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China. zhouling286034705@163.com
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Liyan
authors.initials: L
authors.lastname: Xie
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Ji
authors.forename: Jianming
authors.initials: J
authors.lastname: Cheng
authors.forename: Wenzheng
authors.initials: W
authors.lastname: Ju
authors.forename: Zixiu
authors.initials: Z
authors.lastname: Liu
authors.forename: Shijia
authors.initials: S
authors.lastname: Liu
authors.forename: Hengshan
authors.initials: H
authors.lastname: Tan
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D007773:Lactates / Q000493:pharmacokinetics*; D008297:Male; D012996:Solutions
chemical_list: D004365:Drugs, Chinese Herbal; D007773:Lactates; D012996:Solutions; C035055:3,4-dihydroxyphenyllactic acid