title: Fortifying the link between SIRT1, resveratrol, and mitochondrial function.
abstract: The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. In this issue of Cell Metabolism, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).
authors.affiliation: Wisconsin Institute for Discovery and Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53715, USA. jmdenu@wisc.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Denu