title: Thrombolytic therapy in prosthetic valve thrombosis during early pregnancy.
abstract: Regardless of the improvements in the design of prosthetic heart valves and the use of anticoagulation, systemic embolism and valve thrombosis remains the most dreaded complications of mechanical heart valve replacement. A course of thrombolytic therapy may be considered as a first-line therapy for prosthetic heart valve thrombosis. The safety of thrombolysis in early pregnancy is not known. We describe a primigravida with mitral valve replacement status presenting with acute prosthetic valve thrombosis and treated successfully with intravenous streptokinase.
authors.affiliation: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru.
authors.forename: B C
authors.initials: BC
authors.lastname: Srinivas
authors.forename: Nagaraja
authors.initials: N
authors.lastname: Moorthy
authors.forename: Arora
authors.initials: A
authors.lastname: Kuldeep
authors.forename: Harsha
authors.initials: H
authors.lastname: Jeevan
authors.forename: Danalakshmi
authors.initials: D
authors.lastname: Chandrasekaran
authors.forename: C N
authors.initials: CN
authors.lastname: Manjunath
mesh_terms: D000328:Adult; D018618:Echocardiography, Doppler, Color; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D006801:Humans; D008946:Mitral Valve Stenosis / Q000601:surgery*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase