title: Phorbol esters with wnt signal-augmenting effects isolated from Excoecaria indica.
abstract: A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/beta-catenin (TOP) transcriptional activity at 95 nM.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Toume
authors.forename: Midori A
authors.initials: MA
authors.lastname: Arai
authors.forename: Firoj
authors.initials: F
authors.lastname: Ahmed
authors.forename: Samir K
authors.initials: SK
authors.lastname: Sadhu
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D019665:Euphorbiaceae / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D010703:Phorbol Esters / Q000737:chemistry / Q000302:isolation & purification*; D060449:Wnt Signaling Pathway
chemical_list: D010703:Phorbol Esters