title: Minimally invasive surgical treatment of lone atrial fibrillation: early results of hybrid versus standard minimally invasive approach employing radiofrequency sources.
abstract: BACKGROUND
  We compared short-term results of a hybrid versus a standard surgical bilateral thoracoscopic approach employing radiofrequency (RF) sources in the surgical treatment of lone atrial fibrillation (LAF).
  
  
  METHODS
  Between January 2008 and July 2010 sixty-three consecutive patients with LAF underwent minimally invasive surgery. Thirty-five (55.5%) underwent surgery with the hybrid approach whereas 28 (45.5%) underwent bilateral thoracoscopic standard procedure (no-hybrid group). All patients underwent continuous 7-day Holter Monitoring (HM) at 3 months, 6 months and 1 year.
  
  
  RESULTS
  At 1 year, 91.4% and 82.1% (time-related prevalence 5.2% vs.6.0% [p=0.56]) of the patients were free of AF and AAD. The hybrid group yielded better results in long standing persistent AF (8.2% [time related prevalence 81.8% vs. 44.4%, p=0.001] vs.14.9%, p=0.04). One-year success rates were 87.5% vs. 100% (p=0.04) in persistent [time related prevalence 3.8% vs. 0%, p<0.001] and 87.5% vs. 100% (p=0.04) in paroxysmal AF [time related prevalence 3.2% vs. 0%, p<0.001] in the two groups. One-year prevalence of Warfarin use was significantly higher in the hybrid group (29.0% [26.2-33.1] and 13.4% [9.9-16.3]) with no difference by AF type. LA reverse remodeling occurred in 81.7% (n=30) of hybrid patients and 67.8% (n=19) of no-hybrid patients at latest control (p=0.02). Left atrial emptying fraction increased in both groups (50 ± 14%, p<0.001 and 52 ± 12%, p=0.004 in hybrid and no-hybrid, respectively) without differences between groups (p=0.6).
  
  
  CONCLUSIONS
  The hybrid procedure yielded excellent results in long-standing persistent AF. Our findings need to be confirmed by further larger studies.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital, Maastricht, The Netherlands.
authors.forename: Mark
authors.initials: M
authors.lastname: La Meir
authors.forename: Sandro
authors.initials: S
authors.lastname: Gelsomino
authors.forename: Fabiana
authors.initials: F
authors.lastname: Lucà
authors.forename: Laurant
authors.initials: L
authors.lastname: Pison
authors.forename: Orlando
authors.initials: O
authors.lastname: Parise
authors.forename: Andrea
authors.initials: A
authors.lastname: Colella
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gensini
authors.forename: Harry
authors.initials: H
authors.lastname: Crijns
authors.forename: Francis
authors.initials: F
authors.lastname: Wellens
authors.forename: Jos G
authors.initials: JG
authors.lastname: Maessen
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods* / Q000592:standards; D018619:Echocardiography, Doppler, Pulsed / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods* / Q000592:standards; D017410:Practice Guidelines as Topic / Q000592:standards; D016896:Treatment Outcome