title: Is there a relationship between beginning time and efficiency of octreotide in the treatment of experimental acute pancreatitis?
abstract: OBJECTIVE
  The efficacy of octreotide in the treatment of acute pancreatitis is controversial. Octreotide treatment for acute pancreatitis often shows poor correlation between results obtained in experimental studies and results of clinical trials. In a clinical setting, there is always a delay between the onset of the disease and initiation of the octreotide treatment. The aim of this study is to investigate the relationship between the beginning of treatment and alteration in effectiveness of octreotide.
  
  
  METHODS
  Acute pancreatitis was induced by pancreatic duct ligation in 50 rats. The rats were randomly divided into five groups. Octreotide was not used in group 1 (control group). Only single dose (4 µg/kg) octreotide was administered subcutaneously to rats in group 2, having induced pancreatitis. Octreotide treatment was begun at different times (8th, 24th, 48th hour) in three other groups and continued treatment at a dosage of 4 µg/kg t.i.d. The animals were sacrificed at the end of the 72nd hour and blood and tissue samples were collected.
  
  
  RESULTS
  Leukocyte count and plasma amylase values were less in groups 2 and 3. Hemorrhagic focuses were encountered less at pancreas tissues in group 3. Pancreatic necrosis and alveolar capillary basal membrane damage were lower in groups 3 and 4. No difference was found in fasting blood glucose, calcium and hematocrit.
  
  
  CONCLUSIONS
  Octreotide had benefical effects in acute pancreatitis when octreotide treatment was begun in the first 24 hours.
authors.affiliation: Department of Surgery, Selcuklu Medical Faculty, Selcuk University, Konya, Turkey.
authors.forename: M Ertugrul
authors.initials: ME
authors.lastname: Kafali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Husnu
authors.initials: H
authors.lastname: Alptekin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Hatice
authors.initials: H
authors.lastname: Toy
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akoz