title: PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia.
abstract: PAX5 rearrangements resulting in the expression of fusion transcripts account for 2-3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients.
authors.affiliation: CCRI, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Denk
authors.forename: Karin
authors.initials: K
authors.lastname: Nebral
authors.forename: Jutta
authors.initials: J
authors.lastname: Bradtke
authors.forename: Gertrud
authors.initials: G
authors.lastname: Pass
authors.forename: Anja
authors.initials: A
authors.lastname: Möricke
authors.forename: Andishe
authors.initials: A
authors.lastname: Attarbaschi
authors.forename: Sabine
authors.initials: S
authors.lastname: Strehl
mesh_terms: D017668:Age of Onset; D001483:Base Sequence; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D007223:Infant; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D015514:Oncogene Proteins, Fusion; C554284:PAX5-AUTS2 fusion protein, human