title: Iron metabolism: interactions with normal and disordered erythropoiesis.
abstract: Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.
authors.affiliation: Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. tganz@mednet.ucla.edu
authors.forename: Tomas
authors.initials: T
authors.lastname: Ganz
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Nemeth
mesh_terms: D000740:Anemia / Q000209:etiology; D001692:Biological Transport / Q000502:physiology; D002908:Chronic Disease; D041905:Erythroid Cells / Q000378:metabolism; D004920:Erythropoiesis / Q000502:physiology*; D006453:Hemoglobinopathies / Q000209:etiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism* / Q000502:physiology; D000090463:Iron Deficiencies; D019189:Iron Metabolism Disorders / Q000150:complications*; D008928:Mitochondria / Q000378:metabolism; D014176:Protein Biosynthesis / Q000502:physiology
chemical_list: D007501:Iron