title: Associations between day-by-day variability in blood pressure measured at home and antihypertensive drugs: the J-HOME-Morning study.
abstract: We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
authors.affiliation: Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ishikura
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kato
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuya
authors.forename: Taku
authors.initials: T
authors.lastname: Shibamiya
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shinki
authors.forename: Urara
authors.initials: U
authors.lastname: Ikeda
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Mano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents