title: The multifaceted roles of Eph/ephrin signaling in breast cancer.
abstract: Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In this review we concentrate on their involvement in the normal and carcinogenic development of the breast. In this context we summarize their multi-faceted functions as tumor suppressors, tumor promoters, angiogenic inducers and regulators of stem cell homeostasis.
authors.affiliation: Department of Clinical Research, University of Bern, Bern, Switzerland.
authors.forename: Philip
authors.initials: P
authors.lastname: Kaenel
authors.forename: Mischa
authors.initials: M
authors.lastname: Mosimann
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Andres
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D036342:Ephrins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008954:Models, Biological; D036081:Receptors, Eph Family / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family