title: ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
abstract: METHODS
  Multiple A disintegrin and metalloprotease 33 (ADAM33) single nucleotide polymorphisms (SNPs) have been shown to be associated with asthma, but results have been inconsistent.
  
  
  OBJECTIVE
  To examine the association between ADAM33 SNPs rs2787094, rs628977, rs2280089,  rs2280090, rs2280091, rs2853209, rs528557 and rs612709 and asthma in young adult Japanese women, and to perform haplotype analyses and assess interactions between SNPs and smoking.
  
  
  METHODS
  A total of 89 cases who met the criteria of the European Community Respiratory Health Survey (ECRHS)  for asthma were included in the study. Control subjects were 1281 women without asthma, as per ECRHS criteria, who had not been diagnosed with asthma by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking and education.
  
  
  RESULTS
  Under a co-dominant  model, the AA genotype of the rs612709 SNP was significantly positively associated with asthma compared with the GG genotype: the adjusted OR was 4.27 (95%CI 1.49-12.25). A significant positive relationship was found between the CCGGAAGA haplotype and asthma. Interactions between SNPs  rs628977 and rs528557 and smoking were marginally significant (P = 0.09 and 0.095, respectively).
  
  
  CONCLUSIONS
  ADAM33 SNP rs612709 and the CCGGAAGA haplotype may be associated with asthma. Smoking may modify the associations between SNPs rs628977 and rs528557 and asthma.
authors.affiliation: Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. miyake-y@fukuoka-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011446:Prospective Studies; D012907:Smoking / Q000235:genetics*; D055815:Young Adult
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human