title: The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.
abstract: DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction is one of the major neuropathological findings in this severe disorder. Consistent with these findings, the encoded protein dysbindin-1 has been shown to be diminished in glutamatergic hippocampal neurons in schizophrenic patients. The aim of this study was to investigate the effects of two single nucleotide polymorphisms of DTNBP1 on grey matter volumes in human subjects using voxel-based morphometry. Seventy-two subjects were included and genotyped with respect to two single nucleotide polymorphisms of DTNBP1 (rs2619522 and rs1018381). All participants underwent structural magnetic resonance imaging (MRI). MRI data were preprocessed and statistically analysed using standard procedures as implemented in SPM5 (Statistical Parametric Mapping), in particular the voxel-based morphometry (VBM) toolbox. We found significant effects of the DTNBP1 SNP rs2619522 bilaterally in the hippocampus as well as in the anterior middle frontal gyrus and the intraparietal cortex. Carriers of the G allele showed significantly higher grey matter volumes in these brain regions than T/T homozygotes. Compatible with previous findings on a role of dysbindin in hippocampal functions as well as in major psychoses, the present study provides first direct in vivo evidence that the DTNBP1 SNP rs2619522 is associated with variation of grey matter volumes bilaterally in the hippocampus.
authors.affiliation: Department of Psychiatry and Psychotherapy, Centre for Translational Research in Systems Neuroscience and Clinical Psychiatry, Georg August University, Goettingen, Germany. s.trost@med.uni-goettingen.de
authors.forename: S
authors.initials: S
authors.lastname: Trost
authors.forename: B
authors.initials: B
authors.lastname: Platz
authors.forename: J
authors.initials: J
authors.lastname: Usher
authors.forename: H
authors.initials: H
authors.lastname: Scherk
authors.forename: T
authors.initials: T
authors.lastname: Wobrock
authors.forename: S
authors.initials: S
authors.lastname: Ekawardhani
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: W
authors.initials: W
authors.lastname: Reith
authors.forename: P
authors.initials: P
authors.lastname: Falkai
authors.forename: O
authors.initials: O
authors.lastname: Gruber
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics / Q000473:pathology; D001931:Brain Mapping; D002352:Carrier Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000033:anatomy & histology* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000473:pathology; D012189:Retrospective Studies; D012559:Schizophrenia / Q000235:genetics / Q000473:pathology; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins