title: [Aetiology of surgical infections in patients undergoing craniotomy].
abstract: BACKGROUND
  Postoperative infections in patients undergoing craniotomy constitute significant complications associated with increased hospital stay and patient morbidity and mortality. Knowing the aetiology of surgical infections after craniotomy may contribute to improving antibiotic prophylaxis and empirical treatment.
  
  
  METHODS
  Information relating to surgical infections in patients undergoing craniotomy was obtained from a series of annual surveys on prevalence of infections in Spanish hospitals (EPINE) during the period 1999-2006. The study protocol collected relevant clinical information on patients with infection. Presence of infection was determined according to the Centres for Disease Control infection criteria.
  
  
  RESULTS
  During the time period considered, 107 cases of surgical infections in patients undergoing craniotomy were diagnosed. Forty patients were women (37%) and 67 were male (63%). The mean age was 51.7 years (median 55, range 6-86 years). The duration of the intervention was over 180minutes in 49 patients (45.8%).Thirty-eight patients (35.5%) underwent emergency surgery. Seventy-eight patients (73%) received surgical prophylaxis. Thirty-eight patients (35.5%) had superficial infection of the surgical wound, 38 patients (35.5%) had deep wound infection (including bone flap) and 31 patients (29%), postoperative infections of organ or space (meningitis, subdural empyema or brain abscess). The most common aetiology corresponded to staphylococci (50%), mainly S. aureus (one third of them methicillin-resistant), Pseudomonas aeruginosa (11%), Enterobacter spp (10%) and Acinetobacter baumannii (9%).
  
  
  CONCLUSIONS
  Empirical treatment of these infections should include a glycopeptide such as vancomycin and a beta-lactam with coverage against non-fermenting gram-negative bacilli.
authors.affiliation: Servicio de Medicina Interna, Unidad de Infecciosas, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, España.
authors.forename: Elena
authors.initials: E
authors.lastname: Múñez
authors.forename: Antonio
authors.initials: A
authors.lastname: Ramos
authors.forename: Teresa
authors.initials: T
authors.lastname: Alvarez de Espejo
authors.forename: Josep
authors.initials: J
authors.lastname: Vaqué
authors.forename: José
authors.initials: J
authors.lastname: Sánchez-Payá
authors.forename: Vicente
authors.initials: V
authors.lastname: Pastor
authors.forename: Angel
authors.initials: A
authors.lastname: Asensio
mesh_terms: D019072:Antibiotic Prophylaxis; D003399:Craniotomy; D006801:Humans; D013211:Staphylococcus aureus; D013530:Surgical Wound Infection; D014640:Vancomycin
chemical_list: D014640:Vancomycin