title: Mechanistic insight into pentatricopeptide repeat proteins as sequence-specific RNA-binding proteins for organellar RNAs in plants.
abstract: The pentatricopeptide repeat (PPR) protein family is highly expanded in terrestrial plants. Arabidopsis contains 450 PPR genes, which represents 2% of the total protein-coding genes. PPR proteins are eukaryote-specific RNA-binding proteins implicated in multiple aspects of RNA metabolism of organellar genes. Most PPR proteins affect a single or small subset of gene(s), acting in a gene-specific manner. Studies over the last 10 years have revealed the significance of this protein family in coordinated gene expression in different compartments: the nucleus, chloroplast and mitochondrion. Here, we summarize recent studies addressing the mechanistic aspect of PPR proteins.
authors.affiliation: Department of Research Superstar Program, Institute of Advanced Study, Kyushu University, Fukuoka 812-8581, Japan. tnaka@agr.kyushu-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yagi
authors.forename: Keiko
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D020816:Amino Acid Motifs; D019943:Amino Acid Substitution; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002736:Chloroplasts / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D017393:RNA Editing; D000077278:RNA, Mitochondrial; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D029681:Arabidopsis Proteins; D000077278:RNA, Mitochondrial; D018749:RNA, Plant; D016601:RNA-Binding Proteins; C538752:pentatricopeptide repeat protein, Arabidopsis; D012313:RNA