title: Spatial repellents: from discovery and development to evidence-based validation.
abstract: International public health workers are challenged by a burden of arthropod-borne disease that remains elevated despite best efforts in control programmes. With this challenge comes the opportunity to develop novel vector control paradigms to guide product development and programme implementation. The role of vector behaviour modification in disease control was first highlighted several decades ago but has received limited attention within the public health community. This paper presents current evidence highlighting the value of sub-lethal agents, specifically spatial repellents, and their use in global health, and identifies the primary challenges towards establishing a clearly defined and recommended role for spatial repellent products in disease control.
authors.affiliation: Department of Preventive Medicine & Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. nachee@usuhs.mil
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Achee
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bangs
authors.forename: Robert
authors.initials: R
authors.lastname: Farlow
authors.forename: Gerry F
authors.initials: GF
authors.lastname: Killeen
authors.forename: Steve
authors.initials: S
authors.lastname: Lindsay
authors.forename: James G
authors.initials: JG
authors.lastname: Logan
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Moore
authors.forename: Mark
authors.initials: M
authors.lastname: Rowland
authors.forename: Kevin
authors.initials: K
authors.lastname: Sweeney
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Torr
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Zwiebel
authors.forename: John P
authors.initials: JP
authors.lastname: Grieco
mesh_terms: D000818:Animals; D006801:Humans; D007300:Insect Control / Q000379:methods*; D007302:Insect Repellents / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D007302:Insect Repellents