title: A novel granulation non-solvent addition method containing hydrophilic and lipophilic drugs.
abstract: Atenolol and simvastatin were granulated in combination by non-solvent addition coacervation method to treat hypertension orally. Dissolution test was performed in water containing 0.5% sodium dodecyl sulfate at 37  0.05 degrees C. FTIR spectrometry, X-ray diffractometry and thermal analysis confirmed the absence of any chemical interaction between polymer and the entrapped drugs. The granules size was about 280-619 μm. Scanning electron microscopy reported irregular morphology of granules. The entrapment efficiency was approximately 90% for atenolol and 70% for simvastatin. A controlled release behavior of both drugs but a burst release phenomenon of simvastatin from the formulations were observed. In conclusion, granules loaded with a hydrophilic and a lipophilic drug were successfully prepared.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy & Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
authors.forename: Fatima
authors.initials: F
authors.lastname: Nasim
authors.forename: Rehmana
authors.initials: R
authors.lastname: Rasheed
authors.forename: Shujaat A
authors.initials: SA
authors.lastname: Khan
authors.forename: Muhammad N
authors.initials: MN
authors.lastname: Aamir
authors.forename: Fatima
authors.initials: F
authors.lastname: Rasool
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001262:Atenolol / Q000008:administration & dosage* / Q000737:chemistry; D004338:Drug Combinations; D019821:Simvastatin / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical; D014961:X-Ray Diffraction
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D001262:Atenolol; D019821:Simvastatin