title: EGFR in limbo.
abstract: The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. eck@red.dfci.harvard.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Eck
authors.forename: William C
authors.initials: WC
authors.lastname: Hahn