title: Synthesis of symmetric 1,4-diamino-2-butynes via a Cu(I)-catalyzed one-pot A3-coupling/decarboxylative coupling of a propiolic acid, an aldehyde, and an amine.
abstract: A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed A(3)-coupling/decarboxylative coupling (PA(2)-coupling) of a propiolic acid, an aldehyde, and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes,is described. It is noteworthy that this new multicomponent coupling provides an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-butynes.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Huangdi
authors.initials: H
authors.lastname: Feng
authors.forename: Denis S
authors.initials: DS
authors.lastname: Ermolat'ev
authors.forename: Gonghua
authors.initials: G
authors.lastname: Song
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D003959:Diamines; D011422:Propionates; C063335:1,4-diamino-2-butyne; C011537:propiolic acid