title: Molecular organization of polyene antibiotic amphotericin B studied by means of fluorescence technique.
abstract: Amphotericin B (AmB) is a polyene antibiotic used to treat deep-seated mycoses. Both the pharmaceutical and toxic activities of AmB depend on the molecular organization of the drug. The fluorescence of AmB has proven to be a powerful technique of studying the drug's association state. In particular, fluorescence lifetime appeared to be sensitive to the formation of AmB dimers and aggregated structures. This paper addresses the application of the fluorescence technique in the study of the molecular organization of AmB, and perspectives on future application of this approach are addressed briefly.
authors.affiliation: Department of Biophysics, Institute of Physics, Maria Curie-Sklodowska University, Lublin, Poland. wieslaw.gruszecki@umcs.pl
authors.forename: Wieslaw I
authors.initials: WI
authors.lastname: Gruszecki
authors.forename: Rafal
authors.initials: R
authors.lastname: Luchowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Wasko
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Gryczynski
authors.forename: Ignacy
authors.initials: I
authors.lastname: Gryczynski
mesh_terms: D000666:Amphotericin B / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D005453:Fluorescence; D011090:Polyenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D000890:Anti-Infective Agents; D011090:Polyenes; D000666:Amphotericin B