title: F₂ designs for QTL analysis.
abstract: This chapter covers the procedure of mapping quantitative trait loci (QTLs) in an F(2) breeding design. I describe genetic design, general methods and software, and several commonly used approaches. The genetic design section includes F(2) population construction. Widely used methods and software are introduced in the section of general methods and software. Finally, composite interval mapping, penalized maximum likelihood, and empirical Bayes are described in detail. Some issues related to the F(2) design are discussed.
authors.affiliation: Section on Statistical Genomics, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China. oyzhang@njau.edu.cn
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Zhang
mesh_terms: D001499:Bayes Theorem; D001947:Breeding; D002874:Chromosome Mapping; D016013:Likelihood Functions; D040641:Quantitative Trait Loci / Q000235:genetics*; D012984:Software