title: Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review.
abstract: As a bioabsorbable metal with mechanical properties close to bone, pure magnesium or its alloys have great potential to be developed as medical implants for clinical applications. However, great efforts should be made to avoid its fast degradation in vivo for orthopedic applications when used for fracture fixation. Therefore, how to decease degradation rate of pure magnesium or its alloys is one of the focuses in Research and Development (R&D) of medical implants. It has been recognized that surface modification is an effective method to prevent its initial degradation in vivo to maintain its desired mechanical strength. This article reviews the recent progress in surface modifications for prevention of fast degradation of magnesium or its alloys using in vitro testing model, a fast yet relevant model before moving towards time-consuming and expensive in vivo testing. Pros and cons of various surface modifications are also discussed for the goal to design available products to be applied in clinical trials.
authors.affiliation: Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen, China. jl.wang@siat.ac.cn
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yangde
authors.initials: Y
authors.lastname: Li
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Yuxiao
authors.initials: Y
authors.lastname: Lai
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
mesh_terms: D020341:Absorbable Implants; D000497:Alloys; D000818:Animals; D006801:Humans; D008274:Magnesium; D009983:Orthopedic Equipment; D011474:Prosthesis Design; D013499:Surface Properties
chemical_list: D000497:Alloys; D008274:Magnesium