title: Is 2 weeks of antibiotic therapy enough to treat elderly patients with nontyphoid Salmonella bacteremia? A case report of fatal endovascular infection.
abstract: Nontyphoid Salmonella (NTS) can cause invasive diseases in the elderly. Notably, the most feared complication of NTS bacteremia is endovascular infection. The risk factors for infected aortic aneurysm include old age and atherosclerosis. Extended use of antimicrobial therapy (> 2 weeks) for NTS bacteremia should be considered for those who demonstrate the risk factors for endovascular infection, even when a metastatic focus is clinically elusive. Herein, we report the case of a 75-year-old patient with diabetes mellitus, hypertension, chronic kidney disease, and myocardial infarction who died of an infected aortic aneurysm despite 3 weeks of antibiotic therapy that was administered to treat the initial NTS bacteremia.
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; Institute of Clinical Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Po-Lin
authors.initials: PL
authors.lastname: Chen
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Liang-Miin
authors.initials: LM
authors.lastname: Tsai
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chung-Dann
authors.initials: CD
authors.lastname: Kan
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan. Electronic address: winston@mail.ncku.edu.tw.
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ko
mesh_terms: D000367:Age Factors; D000368:Aged; D000785:Aneurysm, Infected / Q000175:diagnosis / Q000209:etiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000382:microbiology; D001019:Aortic Rupture; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy*; D053821:Cardiovascular Infections / Q000175:diagnosis / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012475:Salmonella; D012480:Salmonella Infections / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents