title: Multidirectional myocardial systolic function in hemodialysis patients with preserved left ventricular ejection fraction and different left ventricular geometry.
abstract: BACKGROUND
  Multidirectional myocardial strain analysis can provide mechanistic insight into the ventricular systolic function and pathophysiology. The aim of this study was to assess the multidirectional systolic function of the left ventricle (LV) and its relationship to LV geometry in hemodialysis patients with preserved left ventricular ejection fraction (LVEF).
  
  
  METHODS
  A total of 98 end-stage renal disease patients (age 46 ± 10 years, 60% men) with preserved LVEF (≥50%) on a maintenance hemodialysis program and 18 healthy volunteers were enrolled. The patients were divided into non-hypertrophic groups (classified as normal LV geometry and concentric remodeling) and hypertrophy groups (classified as eccentric and concentric hypertrophy) according to their LV geometries assessed from LV mass/height(2.7) and relative wall thickness in combination. Multidirectional strain analysis was performed by two-dimensional speckle tracking echocardiography.
  
  
  RESULTS
  Myocardial systolic strain (longitudinal and circumferential) and stress-corrected midwall fraction shorting (sc-MWFS) were lower in the hypertrophy groups compared with non-hypertrophic groups. Longitudinal strain and strain rate were even lower in the concentric hypertrophy group than the eccentric hypertrophy group (-15.5 ± 2.2% versus -17.8 ± 2.6%, P = 0.001; -0.7 ± 0.2 versus -0.9 ± 0.2s(-1), P = 0.016). Impaired longitudinal strain correlated with higher LV mass index (LVMI), relative wall thickness, pre-dialysis systolic blood pressure (SBP), calcium-phosphate product and lower sc-MWFS (all P < 0.0001) and weakly correlated with higher interdialytic weight gain (P = 0.004). Using multivariate linear regression, the independent predictors of LV longitudinal strain were pre-dialysis SBP, LVMI, relative wall thickness and sc-MWFS. There were no differences in LVEF and myocardial function in radial direction among all groups.
  
  
  CONCLUSIONS
  In hemodialysis patients with LV hypertrophy, myocardial function was impaired not only in longitudinal direction but also in circumferential direction despite preserved LVEF. Low longitudinal strain is related to LV hypertrophy, concentric geometry and pre-dialysis blood pressure.
authors.affiliation: Department of Ultrasound Diagnostics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Yao
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Tie-sheng
authors.initials: TS
authors.lastname: Cao
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
mesh_terms: D000328:Adult; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013318:Stroke Volume; D013599:Systole