title: Rapid urinary trypsinogen-2 test in the early diagnosis of acute pancreatitis: a meta-analysis.
abstract: OBJECTIVE
  Urinary trypsinogen-2 has been implicated as a promising biomarker for the early diagnosis of acute pancreatitis (AP). The meta-analysis was used to establish the overall accuracy of urinary trypsinogen-2 test for diagnosing AP.
  
  
  METHODS
  Based on comprehensive searches of the PubMed and Embase databases, we identified and abstracted outcome data from all articles evaluating the diagnostic value of urinary trypsinogen-2. A summary estimate for sensitivity, specificity, 95% confidence region and 95% prediction region was calculated using the bivariate random-effects approach.
  
  
  RESULTS
  The meta-analysis included 13 studies (2342 patients, the proportion of severe AP from 13.21% to 30.00%). Overall, the pooled sensitivity was 82.3% (95%CI 79.3%-85.1%) and specificity was 93.5% (95%CI 92.2%-94.6%). The diagnostic odds ratios (DOR) was 85.23 (95%CI 40.14-180.99). The area under the summary ROC curve (AUC) was 0.9673.
  
  
  CONCLUSIONS
  The urinary trypsinogen-2 test is a reliable and rapid method for the early diagnosis of AP.
authors.affiliation: Department of Clinical Laboratory Medicine, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chang
authors.forename: Weiping
authors.initials: W
authors.lastname: Lu
authors.forename: Kejun
authors.initials: K
authors.lastname: Zhang
authors.forename: Shuangrong
authors.initials: S
authors.lastname: Jia
authors.forename: Fake
authors.initials: F
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Shaoli
authors.initials: S
authors.lastname: Deng
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D016001:Confidence Intervals; D016208:Databases, Factual; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010195:Pancreatitis / Q000175:diagnosis* / Q000453:epidemiology; D017594:Publication Bias; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014357:Trypsin / Q000652:urine*; D014362:Trypsinogen / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; C064831:PRSS2 protein, human; D014362:Trypsinogen; D014357:Trypsin