title: TH17 deficiency in human disease.
abstract: The differentiation of naive T cells into distinct subsets of effector T cells is critical for effective immunity against a wide variety of infectious agents in the environment. Activation of innate immune responses by Candida species through pattern-recognition receptors directs the subsequent development of naive T cells into T(H)17 cells, which are essential for effective mucosal immunity against fungi. Thorough analyses of cohorts of patients with unusual susceptibility to chronic mucocutaneous candidiasis resulting from T(H)17 deficiency have confirmed the role of T(H)17 cells and T(H)17 cytokines in human host defense against Candida species and have provided valuable insights into the complex process of T(H)17 cell development.
authors.affiliation: Division of Immunology, Children's Hospital, Boston and Harvard Medical School, Boston, MA 02115, USA. douglas.mcdonald@childrens.harvard.edu
authors.forename: Douglas R
authors.initials: DR
authors.lastname: McDonald
mesh_terms: D002178:Candidiasis, Chronic Mucocutaneous / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate; D007589:Job Syndrome / Q000235:genetics / Q000276:immunology; D009154:Mutation; D050794:STAT1 Transcription Factor / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; C516591:DOCK8 protein, human; D020662:Guanine Nucleotide Exchange Factors; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor