title: Influence of systemic antibiotics on the treatment of dogs with generalized demodicosis.
abstract: Canine generalized demodicosis (CGD) is a skin disease with distinct breed predispositions. Secondary bacterial infections are common. Dogs typically receive miticidal therapy in combination with antibacterial treatment. Whether antibiotics influence the duration of acaricidal therapy is unknown at the moment. There is also debate over how common short-tailed Demodex mites occur in demodicosis. This study evaluated the influence of systemic antibiotics on the course of CGD, the occurrence of short-tailed Demodex mites in demodectic dogs and the influence of furunculosis on treatment outcome. Breed predispositions for CGD in Moscow were identified. Fifty-eight dogs were randomly distributed in two groups. Both were treated with ivermectin 600 mcg/kg q24h orally and benzoyl peroxide shampoo weekly. The dogs in one group (AB) were additionally treated with systemic antibiotics for at least 1 month, dogs in the other group (NAB) were not. Monthly examinations, skin scrapings and impression smears were performed. Prior to the study there was no difference in clinical severity, presence of pyoderma and mite numbers between groups. There was no significant difference in duration until first negative skin scrapings and resolution of bacterial infection. In dogs with furunculosis the number of the mites was significantly higher than in dogs without furunculosis but the duration until microscopic remission albeit longer, was not significantly different. Short-tailed Demodex mites were found in 25% of the cases. Pugs and English Bulldogs were predisposed. Based on these results, systemic antibiotics may not impact as much as previously thought on the actual success of CGD treatment.
authors.affiliation: Clinic of Veterinary Medicine Beliy Klik, Krasnaya Presnya 6/2, Bld 2, 123242 Moscow, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Kuznetsova
authors.forename: Sonya
authors.initials: S
authors.lastname: Bettenay
authors.forename: Lyubov
authors.initials: L
authors.lastname: Nikolaeva
authors.forename: Monir
authors.initials: M
authors.lastname: Majzoub
authors.forename: Ralf
authors.initials: R
authors.lastname: Mueller
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D007559:Ivermectin / Q000627:therapeutic use; D008297:Male; D008924:Mite Infestations / Q000150:complications / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D014052:Toluidines / Q000627:therapeutic use
chemical_list: D056810:Acaricides; D000900:Anti-Bacterial Agents; D014052:Toluidines; C014983:amitraz; D007559:Ivermectin; D001585:Benzoyl Peroxide