title: Caffeoylserotonin suppresses THP-1 monocyte adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway.
abstract: We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. CaS decreased monocyte adhesion and migration induced by MCP-1, together with CCR2 expression and α5β1 integrin, and activated β1 integrin expression on the cell surface. CaS also inhibited FAK and Akt phosphorylation. We found that CaS had anti-inflammatory activity based on inhibition of adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway. Thus, the inhibitory effects of CaS on monocyte function may support the future development of this compound as a potential treatment for inflammation-dependent diseases.
authors.affiliation: Department of Molecular Biotechnology, Chonnam National University, Gwangju 500-757, South Korea.
authors.forename: Ji-Hae
authors.initials: JH
authors.lastname: Yoon
authors.forename: Hye-Eun
authors.initials: HE
authors.lastname: Kim
authors.forename: Jang-Yeol
authors.initials: JY
authors.lastname: Choi
authors.forename: Hyeun-Jong
authors.initials: HJ
authors.lastname: Bae
authors.forename: Seong-Gene
authors.initials: SG
authors.lastname: Lee
mesh_terms: D017209:Apoptosis; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D005786:Gene Expression Regulation; D039081:Integrin alpha5beta1 / Q000235:genetics / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D054390:Receptors, CCR2 / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction
chemical_list: C515334:CCR2 protein, human; D002109:Caffeic Acids; D039081:Integrin alpha5beta1; C534691:N-caffeoylserotonin; D054390:Receptors, CCR2; D012701:Serotonin; D051057:Proto-Oncogene Proteins c-akt