title: Ethylmalonic encephalopathy associated with crescentic glomerulonephritis.
abstract: Ethylmalonic encephalopathy (EE) is a rare autosomal recessive disorder caused by mutations in the ETHE1 gene and characterized by chronic diarrhea, encephalopathy, relapsing petechiae and acrocyanosis. Nephrotic syndrome has been described in an infant with EE but the renal histology findings were not described in previous reports. We report a Palestinian girl with EE who presented with chronic diarrhea, encephalopathy, petechial rash and acrocyanosis. Subsequently, she developed progressive deterioration of renal function caused by rapidly progressive glomerulonephritis resulting in death within few days. This is, to our knowledge, the first reported occurrence of rapidly progressive glomerulonephritis in a child with ethylmalonic encephalopathy. Its presence is a serious complication associated with poor prognosis and may be explained by the diffuse vascular damage.
authors.affiliation: Makassed Hospital, Al-Quds University, Jerusalem, Israel. imaddweikat@yahoo.ca
authors.forename: Imad
authors.initials: I
authors.lastname: Dweikat
authors.forename: Enas
authors.initials: E
authors.lastname: Naser
authors.forename: Nadera
authors.initials: N
authors.lastname: Damsah
authors.forename: Bassam Abu
authors.initials: BA
authors.lastname: Libdeh
authors.forename: Izzeddin
authors.initials: I
authors.lastname: Bakri
mesh_terms: D020739:Brain Diseases, Metabolic, Inborn / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D003241:Consanguinity; D005076:Exanthema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism; D008314:Malonates / Q000378:metabolism*; D009154:Mutation / Q000235:genetics / Q000502:physiology; D009404:Nephrotic Syndrome / Q000150:complications; D010375:Pedigree; D011507:Proteinuria / Q000209:etiology / Q000378:metabolism; D011693:Purpura / Q000150:complications* / Q000378:metabolism* / Q000473:pathology
chemical_list: D008314:Malonates; C038080:ethylmalonic acid