title: Centroblastic diffuse large B cell lymphoma displays distinct expression pattern and prognostic role of apoptosis resistance related proteins.
abstract: Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.
authors.affiliation: Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação Geral Técnico-Científica, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
authors.forename: Roberta Soares
authors.initials: RS
authors.lastname: Faccion
authors.forename: Lidia Maria Magalhães
authors.initials: LM
authors.lastname: Rezende
authors.forename: Sérgio de Oliveira
authors.initials: Sde O
authors.lastname: Romano
authors.forename: Ricardo de Sá
authors.initials: Rde S
authors.lastname: Bigni
authors.forename: Gelcio Luiz Quintella
authors.initials: GL
authors.lastname: Mendes
authors.forename: Raquel Ciuvalschi
authors.initials: RC
authors.lastname: Maia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D000077022:Survivin; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000032:analysis
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D016159:Tumor Suppressor Protein p53; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human