title: Glucosylated sesquiterpene alcohols from Fraxinus griffithii.
abstract: Phytochemical investigation of the leaves of Fraxinus griffithii has led to the isolation of two new glucosylated acyclic sesquiterpene alcohols, griffithosides D (1) and E (2), along with iridoid and secoiridoid glycosides. The molecular structures of these compounds were elucidated using NMR, MS and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity and cytotoxicity against A549 human lung adenocarcinoma cells and Leishmania major parasites.
authors.affiliation: Department of Chemistry, School of Science and Engineering, Ateneo de Manila University, Katipunan Avenue, Loyola Heights, Quezon City 1108, Philippines. rmacahig@ateneo.edu
authors.forename: Rene Angelo
authors.initials: RA
authors.lastname: Macahig
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takeda
authors.forename: Takakazu
authors.initials: T
authors.lastname: Shinzato
mesh_terms: D000438:Alcohols / Q000737:chemistry / Q000302:isolation & purification; D000977:Antiparasitic Agents / Q000032:analysis; D031661:Fraxinus / Q000737:chemistry*; D018320:Leishmania major; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000438:Alcohols; D000977:Antiparasitic Agents; D012717:Sesquiterpenes; C572479:griffithoside D; C572478:griffithoside E