title: Effect of lignin-derived lignophenols on hepatic lipid metabolism in rats fed a high-fat diet.
abstract: The effect of lignin-derived lignophenols on lipid metabolism in the livers of rats fed a high-fat diet was investigated. Rats fed a diet providing 45% of energy from fat were divided into 2 groups, namely 0% and 0.5% lignophenols-containing diets. The controls were fed a diet providing 10% of energy from fat. Plasma blood parameters, protein expression of acetyl-CoA carboxylase (ACC) and sterol regulatory element-binding protein (SREBP)-1, and SREBP-1c mRNA expression in the livers were examined. The plasma triglyceride levels in the rats fed lignophenols-containing diets were decreased. SREBP-1c mRNA expression in the rats fed lignophenols-containing diets was significantly reduced compared with the rats fed high-fat diets, and phosphorylated ACC protein in the rats fed lignophenols-containing diets was significantly increased. Our results suggested that lignophenols suppress the expression of SREBP-1c mRNA and the phosphorylation of ACC in the liver, and may lead to a decrease in plasma triglyceride levels.
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-0841, Japan. Electronic address: s_sato3@auhw.ac.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-0841, Japan.
authors.forename: Yuuka
authors.initials: Y
authors.lastname: Mukai
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-0841, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Tokuoka
authors.affiliation: Department of Environmental Science and Technology, Faculty of Bioresources, Mie University, Tsu 514-8507, Japan.
authors.forename: Keigo
authors.initials: K
authors.lastname: Mikame
authors.affiliation: Department of Environmental Science and Technology, Faculty of Bioresources, Mie University, Tsu 514-8507, Japan.
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Funaoka
authors.affiliation: Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-0841, Japan.
authors.forename: Shuzo
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D059305:Diet, High-Fat; D008031:Lignin / Q000737:chemistry; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D010636:Phenols; D012333:RNA, Messenger; D051780:Sterol Regulatory Element Binding Protein 1; D014280:Triglycerides; D008031:Lignin; D000103:Acetyl-CoA Carboxylase