title: Role of neurotrophins in the development and function of neural circuits that regulate energy homeostasis.
abstract: Members of the neurotrophin family, including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, and other neurotrophic growth factors such as ciliary neurotrophic factor and artemin, regulate peripheral and central nervous system development and function. A subset of the neurotrophin-dependent pathways in the hypothalamus, brainstem, and spinal cord, and those that project via the sympathetic nervous system to peripheral metabolic tissues including brown and white adipose tissue, muscle and liver, regulate feeding, energy storage, and energy expenditure. We briefly review the role that neurotrophic growth factors play in energy balance, as regulators of neuronal survival and differentiation, neurogenesis, and circuit formation and function, and as inducers of critical gene products that control energy homeostasis.
authors.affiliation: Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Samira
authors.initials: S
authors.lastname: Fargali
authors.forename: Masato
authors.initials: M
authors.lastname: Sadahiro
authors.forename: Cheng
authors.initials: C
authors.lastname: Jiang
authors.forename: Amy L
authors.initials: AL
authors.lastname: Frick
authors.forename: Tricia
authors.initials: T
authors.lastname: Indall
authors.forename: Valeria
authors.initials: V
authors.lastname: Cogliani
authors.forename: Jelle
authors.initials: J
authors.lastname: Welagen
authors.forename: Wei-Jye
authors.initials: WJ
authors.lastname: Lin
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Salton
mesh_terms: D000273:Adipose Tissue / Q000294:innervation / Q000502:physiology; D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000502:physiology; D001481:Basal Metabolism / Q000502:physiology; D001933:Brain Stem / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D009414:Nerve Growth Factors / Q000494:pharmacology / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D005938:Glucocorticoids; D009414:Nerve Growth Factors; D009479:Neuropeptides; D017475:Receptors, Nerve Growth Factor; D003346:Corticotropin-Releasing Hormone