title: Effective Prolonged Therapy with Voriconazole in a Lung Transplant Recipient with Spondylodiscitis Induced by Scedosporium apiospermum.
abstract: Scedosporium/Pseudallescheria species are frequently seen in cystic fibrosis patients. However, disseminated forms after lung transplantation in these patients are rarely seen, but often with poor outcome. In this case report we describe a lung transplant recipient with cystic fibrosis who developed a spondylodiscitis that was caused by Scedosporium apiospermum. The patient was treated with anti-fungal treatment by voriconazole for over three years with a clinical good response and without the need for surgical intervention. To our opinion this is the first anti-fungal treated case of invasive disease caused by Scedosporium/Pseudallescheria in a cystic fibrosis (CF) patient who underwent lung transplantation that survived.
authors.affiliation: Division of Heart and Lungs, Departments of Respiratory Medicine and Lung Transplantation, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Luijk
authors.forename: M B
authors.initials: MB
authors.lastname: Ekkelenkamp
authors.forename: P A
authors.initials: PA
authors.lastname: De Jong
authors.forename: J M
authors.initials: JM
authors.lastname: Kwakkel-van Erp
authors.forename: J C
authors.initials: JC
authors.lastname: Grutters
authors.forename: D A
authors.initials: DA
authors.lastname: van Kessel
authors.forename: E A
authors.initials: EA
authors.lastname: van de Graaf