title: Protective effect of polysaccharides on the stability of parenteral emulsions.
abstract: The main purpose of this study is to investigate the influence of two polysaccharides (dextran, hydroxyethyl starch) on the stability of parenteral emulsions. All parenteral emulsions were prepared by high-pressure homogenization. The influence of polysaccharides concentration was studied. The stabilities of autoclaving sterilization, centrifugation and freeze-thawing process were investigated extensively. Following the addition of polysaccharides, the stabilities of the parenteral emulsions were improved. A high-concentration polysaccharides solution (13%, w/v) produced better protection than a low one (1.3%, w/v), especially during freeze-thawing process. The protective mechanisms of polysaccharides were attributed to increasing systematic viscosity, non-frozen water absorbed by polysaccharides, formation of a linear bead-like structure and thicker mixed emulsifier film. Overall, polysaccharides can offer greatly increased protection for parenteral emulsions, and represent a novel protective strategy for improving the stability of this delivery system.
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Guihong
authors.initials: G
authors.lastname: Chai
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.forename: Jianli
authors.initials: J
authors.lastname: Shi
authors.forename: Bin
authors.initials: B
authors.lastname: Tian
authors.forename: Xing
authors.initials: X
authors.lastname: Tang
mesh_terms: D002498:Centrifugation / Q000379:methods; D002626:Chemistry, Pharmaceutical; D003911:Dextrans / Q000737:chemistry*; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D005615:Freezing; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry*; D007263:Infusions, Parenteral; D010288:Parenteral Nutrition; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010952:Plasma Substitutes / Q000737:chemistry; D013242:Sterilization / Q000379:methods; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D003911:Dextrans; D045703:Emulsifying Agents; D004655:Emulsions; D006895:Hydroxyethyl Starch Derivatives; D004364:Pharmaceutical Preparations; D010952:Plasma Substitutes; D013501:Surface-Active Agents