title: Trends in the indications for penetrating keratoplasty in Shandong, 2005-2010.
abstract: OBJECTIVE
  To identify the current indications and the trend shifts for penetrating keratoplasty (PKP) in Shandong.
  
  
  METHODS
  The medical charts of all patients who underwent PKP at Shandong Eye Institute from June 1, 2005 to May 31, 2010 were analysed retrospectively.
  
  
  RESULTS
  A total of 875 patients (875 eyes) received PKP in this 5-year period, accounting for 61.6% of all corneal transplantation surgeries. The leading indications for PKP were infectious keratitis (37.1%), HSK (19.1%), keratoconus (11.2%), bullous keratopathy (8.5%), regrafting (6.7%) and corneal scarring (4.8%). The percentage of PKP for keratoconus declined year by year, whereas the percentage of bullous keratopathy had a mild annual increase. Fungal infections accounted for 65.2% of the infectious keratitis cases, remaining the leading cause of corneal infection. In addition, 54.1% of bullous keratopathy cases were associated with cataract surgery. The leading initial diagnoses associated with regrafting were infectious keratitis (38.9%), HSK (18.6%) and corneal burn (16.9%). The major causes of regrafting included graft endothelial dysfunction (39.0%), graft ulcer (28.8%) and primary disease recurrence (15.3%).
  
  
  CONCLUSIONS
  Infectious keratitis remained the leading indication for PKP in Shandong, and fungal infections were still the major cause of corneal infections. There was an increasing trend in the percentage of PKP cases indicated for bullous keratopathy but a decline in the same for keratoconus. Even with a decline in the overall proportion among all corneal transplantation surgeries, PKP is still the major corneal transplant choice in Shandong.
authors.affiliation: Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Wang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Xie
authors.forename: Xiu-Sheng
authors.initials: XS
authors.lastname: Song
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao