title: Current concepts in pediatric liver tumors.
abstract: Liver tumors in children can be classified into benign or malignant; some of the benign lesions can have the potential of malignant transformation, and therefore the therapeutic approach may change. These neoplasms account for nearly 1-2% of all pediatric tumors and they have gained significant attention in the last decades due to data suggesting that the incidence may be increasing 5% annually. We know that with new and improved imaging modalities some of these lesions may be detected more often than before. Recent studies showed that liver cancer represented 2% of malignancies in infants by 1980s and this was doubled in incidence to 4% in the following 10 yr. In this review our aim is to discuss all primary liver tumors in children with attention to their clinicopathological and immunohistochemical features followed by the current standard of care.
authors.affiliation: Department of Surgery, Yale University School of Medicine, Yale, New Haven, CT, USA. sukru.emre@yale.edu
authors.forename: Sukru
authors.initials: S
authors.lastname: Emre
authors.forename: Veysel
authors.initials: V
authors.lastname: Umman
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodriguez-Davalos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008495:Medical Oncology / Q000379:methods / Q000639:trends; D009367:Neoplasm Staging; D012307:Risk Factors