title: Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats.
abstract: High fructose feeding (66 % of fructose) induces type-2 diabetes in rats, which is associated with the insulin resistance, hyperinsulinemia, hypertriglyceridemia and oxidative stress. The present study was undertaken to evaluate the effect of ethanol extract of Commiphora mukul gum resin (CMEE) on blood glucose, plasma insulin, lipid profiles, reduced glutathione, lipid peroxidation, protein oxidation and enzymatic antioxidants like superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, glutathione-S-transferase in fructose-induced type-2 diabetic rats. A significant gain in body weight, hyperglycemia, hyperinsulinemia, increased lipid profiles, lipid peroxidation, protein oxidation and decreased reduced glutathione, activities of enzymatic antioxidants and insulin sensitivity (increased homeostasis assessment assay) were observed in high-fructose-induced diabetic rats. The administration of CMEE (200 mg/kg/day) daily for 60 days in high-fructose-induced diabetic rats reversed the above parameters significantly. CMEE has the ability to improve insulin sensitivity and delay the development of insulin resistance, aggravate antioxidant status in diabetic rats and may be used as an adjuvant therapy for patients with insulin resistance.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India.
authors.forename: B
authors.initials: B
authors.lastname: Ramesh
authors.forename: D
authors.initials: D
authors.lastname: Saralakumari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001786:Blood Glucose; D029744:Commiphora / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D000431:Ethanol / Q000737:chemistry; D005632:Fructose / Q000009:adverse effects*; D006946:Hyperinsulinism / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D015228:Hypertriglyceridemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology; D053149:Plant Gums / Q000737:chemistry*; D051381:Rats; D012997:Solvents / Q000737:chemistry; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D053149:Plant Gums; D012997:Solvents; D005632:Fructose; D000431:Ethanol