title: New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production.
abstract: A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.
authors.affiliation: College of Pharmacy, Nankai University, Tianjin 300071, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Da-qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamakuni
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D000818:Animals; D002460:Cell Line; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D018517:Plant Roots / Q000737:chemistry
chemical_list: D004224:Diterpenes; D008070:Lipopolysaccharides; D009569:Nitric Oxide