title: Primary extranodal non-Hodgkin's lymphoma of the vagina: a case report and a review of the literature.
abstract: Primary lymphoma of the female genital tract is very rare. We report the case of a 36-year-old woman who was referred to our hospital because of an indeterminate Pap smear test. The colposcopy showed a thickening of the posterior vaginal wall and various irregular ulcerated nodular lesions. Histological examination, immunohistochemistry and the staging procedures were conclusive of diffuse large B-cell lymphoma of the vagina, stage IEA. Complete remission was achieved after 6 cycles of immunopolychemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). No relapse has occurred during a follow-up of 71 months. Moreover, we reviewed the 62 previously reported cases of primary extranodal non-Hodgkin's lymphoma of the vagina, focusing on clinicopathological and therapeutic aspects, to better characterize this unusual disease.
authors.affiliation: Division of Hematology, Second University of Naples, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Guastafierro
authors.forename: Amando
authors.initials: A
authors.lastname: Tedeschi
authors.forename: Clelia
authors.initials: C
authors.lastname: Criscuolo
authors.forename: Maria
authors.initials: M
authors.lastname: Celentano
authors.forename: Luigi
authors.initials: L
authors.lastname: Cobellis
authors.forename: Raffaele
authors.initials: R
authors.lastname: Rossiello
authors.forename: Umberto
authors.initials: U
authors.lastname: Falcone
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003127:Colposcopy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents