title: [Distribution characteristics of cancerous foci in the prostate among patients undergoing single positive core biopsy].
abstract: OBJECTIVE
  To determine the distribution characteristics of cancerous foci in the prostate by retrospective analysis on the radical prostatectomy (RP) samples from patients with prostate cancer diagnosed by single positive core biopsy and treated by RP.
  
  
  METHODS
  Thirty-seven patients with prostate cancer diagnosed by ultrasound-guided biopsy and single positive core biopsy underwent RP. We reviewed the pre- and post-operative data of the patients, compared the results of biopsies and pathological examination of the RP samples, and analyzed the factors that led to the underestimation of the overall prostate cancer risks.
  
  
  RESULTS
  Post-operative pathological results showed multifocal distribution of the tumors in 70% of the patients (26/37) and obviously increased Gleason score (7-9) in 56% (21/37). The clinical stages of the tumors had been significantly underestimated preoperatively. The underestimation of their clinical stages might be due to a larger proportion of cancer tissues in a single positive core biopsy, and that of the overall cancer risks attributed to PSAD > 0.2 microg/L. Larger prostate volume (> or = 40 ml) increased the possibility of multifocal distribution.
  
  
  CONCLUSIONS
  The risk of prostate cancer diagnosed by single positive core biopsy might be underestimated, and the cancerous foci were characterized by multifocal distribution in the prostate.
authors.affiliation: Department of Urology/Peking University Institute of Urology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Xi-Gao
authors.initials: XG
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Shen
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.forename: Shu-Qing
authors.initials: SQ
authors.lastname: Li
authors.forename: Gang-Zhi
authors.initials: GZ
authors.lastname: Shan
authors.forename: Shi-Liang
authors.initials: SL
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies