title: Deformable anatomic templates embed knowledge into patient's brain images: Part 1. Construction and display.
abstract: OBJECTIVE
  This paper describes the methods used to create annotated deformable anatomic templates (DATs) and display them in a patient's axial 2-dimensional and reformatted volume brain images.
  
  
  METHODS
  A senior neuroradiologist annotated and manually segmented 1185 color-coded structures on axial magnetic resonance images of a normal template brain using domain knowledge from multiple medical specialties. Besides the visible structures, detailed pathways for vision, speech, cognition, and movement were charted. This was done by systematically joining visible anatomic anchor points and selecting the best fit based on comparisons with cadaver dissections and the constraints defined on the companion 2-dimensional images.
  
  
  RESULTS
  The DAT is commercially available for use on a picture archiving and communication system or as a standalone workstation.
  
  
  CONCLUSIONS
  The DAT can quickly embed extensive, clinically useful functional neuroanatomic knowledge into the patient's brain images. Besides labeling visible structures, DAT displays clinically important, previously uncharted subdivisions of the fiber tracts.
authors.affiliation: Anatom-e Information Systems, Ltd,Houston, TX 77030, USA. Anne@Anatom-e.com
authors.forename: L Anne
authors.initials: LA
authors.lastname: Hayman
authors.forename: Vinodh A
authors.initials: VA
authors.lastname: Kumar
authors.forename: Jackson
authors.initials: J
authors.lastname: Hamilton
authors.forename: Sujit S
authors.initials: SS
authors.lastname: Prabhu
authors.forename: Michel
authors.initials: M
authors.lastname: Thiebaut de Schotten
authors.forename: Nagham
authors.initials: N
authors.lastname: Al-Zubidi
authors.forename: John
authors.initials: J
authors.lastname: Pagani
authors.forename: Mark
authors.initials: M
authors.lastname: Vabulas
authors.forename: Megan
authors.initials: M
authors.lastname: Groneman
authors.forename: Ashok J
authors.initials: AJ
authors.lastname: Kumar
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012016:Reference Values