title: Expression of MUC1 (Ma695) in noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification of the noninvasive urothelial neoplasm. An immunologic tool for the pathologist?
abstract: OBJECTIVE
  To examine the association between MUC1 (Ma695) and noninvasive papillary urothelial neoplasm according to the 2004 World Health Organization classification.
  
  
  METHODS
  Histologic evaluation was performed in 46 patients with nontumoral benign bladder urothelium (n = 11), papillary urothelial neoplasm of low malignant potential (PUNLMP) (n = 14), low-grade papillary urothelial carcinoma (LgPUC) (n = 11), and noninvasive high-grade papillary urothelial carcinoma (HgPUC) (n = 10). Classical morphologic description and semiquantitative digital measurement were performed from immunohistochemical-stained slides using an anti-MUC1 antibody (Ma695).
  
  
  RESULTS
  Measures showed an obvious statistical difference between benign urothelium and LgPUC (p = 0.0004) or HgPUC (p = 0.0041). MUC1 is expressed less in PUNLMP than in LgPUC (p = 0.04). Benign urothelium and PUNLMP more often showed apical and superficial MUC1 expression. Basal cells with cytoplasmic and/or circumferential membrane positivity were more often observed in LgPUC and HgPUC (p < 0.001).
  
  
  CONCLUSIONS
  MUC1 could be an interesting tool for the pathologist to differentiate between PUNLMP and LgPUC or HgPUC.
authors.affiliation: Department of Biopathology, Institut Jean-Godinot, Centre Régional de Lutte Contre le Cancer, Reims Cedex, France. christian.garbar@reims.unicancer.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Garbar
authors.forename: Corinne
authors.initials: C
authors.lastname: Mascaux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000145:classification / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010338:Pathology, Clinical / Q000379:methods; D001749:Urinary Bladder Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology; D019459:Urothelium / Q000378:metabolism* / Q000473:pathology; D014944:World Health Organization; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1