title: Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis.
abstract: Q fever is a worldwide zoonotic infection that caused by Coxiella burnetii, a strict intracellular bacterium. It may be manifested by some of the autoimmune events and is classified into acute and chronic forms. The most frequent clinical manifestation of acute form is a self-limited febrile illness which is associated with severe headache, muscle ache, arthralgia and cough. Meningoencephalitis, thyroiditis, pericarditis, myocarditis, mesenteric lymphadenopathy, hemolytic anemia, and nephritis are rare manifestations. Here we present a case of acute Q fever together with Coombs' positive autoimmune hemolytic anemia (AIHA) and tubulointerstitial nephritis treated with chlarithromycin, steroids and hemodialysis. Clinicians should be aware of such rare manifestations of the disease.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. srdlkorkmaz@mynet.com
authors.forename: Serdal
authors.initials: S
authors.lastname: Korkmaz
authors.forename: Nazif
authors.initials: N
authors.lastname: Elaldi
authors.forename: Mansur
authors.initials: M
authors.lastname: Kayatas
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sencan
authors.forename: Esin
authors.initials: E
authors.lastname: Yildiz
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D017291:Clarithromycin / Q000627:therapeutic use; D003298:Coombs Test; D016997:Coxiella burnetii / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D011778:Q Fever / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D017291:Clarithromycin; D008775:Methylprednisolone