title: Evaluation of sterile uveitis after iris-fixated phakic intraocular lens implantation.
abstract: OBJECTIVE
  To evaluate the clinical features, and visual outcomes of sterile uveitis after iris-fixated phakic intraocular lens implantation (pIOLs) (Artisan-Artiflex(®) and Verisyse-Veriflex(®)).
  
  
  METHODS
  In this retrospective non-comparative case series, the medical records of 117 eyes implanted with Artisan-Artiflex(®) (Ophtec BV, Groningen, Netherlands) and Verisyse-Veriflex(®) (AMO, Santa Ana, CA) iris claw phakic IOLs were analyzed for postimplantation sterile uveitis. The mean age of the 87 patients included in the study was 27.2±7.4 years. Of these patients, 56 (64.3%) were men and 31 (35.6%) were women. Patient age, gender, IOL brand type, refractive error, optic diameter, unilateral vs bilateral implantation, and anterior chamber depth were analyzed. Features of uveitis, uncorrected and best corrected visual acuity (VA) at presentation and at follow-up visits were examined. The mean follow-up time was 14.6 months (range: 6-37 months).
  
  
  RESULTS
  Clinically significant uveitis was observed in 12 of 117 eyes (10.3%) in a total of ten patients. Of these ten patients, four (40%) were women and six (60%) were men, and the mean age was 25.1±5.3 years (range: 18-36 years). Among those with bilateral implantation, 6.9% of patients developed bilateral uveitis, while 13.8% (4 of the 29 implanted bilaterally) developed unilateral uveitis. Foldable pIOL implantation was the only variable associated with the development of uveitis (P=.03).
  
  
  CONCLUSIONS
  Although the prognosis is usually benign, sterile uveitis occurred in 10.3% of patients after iris-fixated pIOL implantation. The implantation of a foldable pIOL was the only variable associated with sterile uveitis. Appropriate medical management can be effective treatment, without the need for pIOL replacement.
authors.affiliation: Khatam-Al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Mashad, Iran.
authors.forename: Mohamadreza
authors.initials: M
authors.lastname: Sedaghat
authors.forename: Mehran
authors.initials: M
authors.lastname: Zarei-Ghanavati
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Ansari-Astaneh
authors.forename: Virag
authors.initials: V
authors.lastname: Patel
authors.forename: Shameema
authors.initials: S
authors.lastname: Sikder
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007498:Iris / Q000601:surgery*; D008297:Male; D009216:Myopia / Q000601:surgery*; D054120:Phakic Intraocular Lenses / Q000009:adverse effects*; D011183:Postoperative Complications; D012189:Retrospective Studies; D014605:Uveitis / Q000209:etiology*; D014792:Visual Acuity; D055815:Young Adult