title: Bacillus cereus septicemia attributed to a matched unrelated bone marrow transplant.
abstract: BACKGROUND
  Hematopoietic cell transplantation (HCT) is performed in more than 25,000 patients annually. Clinically significant bacterial transmission from HCT products is rare.
  
  
  METHODS
  A 36-year-old male of Asian descent with chronic myelogenous leukemia developed sepsis leading to acute renal failure and disseminated intravascular coagulation during infusion of matched unrelated donor bone marrow. This product later tested positive for Bacillus cereus.
  
  
  CONCLUSIONS
  This HCT product traveled 31 hours at room temperature before arriving at the transplant center. Reducing transport times, transporting at 4 °C, and enhancing bacterial surveillance of HCT products may increase the ability to detect bacterial proliferation from transport.
  
  
  CONCLUSIONS
  To prevent a similar case in the future, we will begin Gram staining all HCT products in transit more than 24 hours to alert physicians of the need for prophylactic antibiotic therapy.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Kelley
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Onderdonk
authors.forename: Grace
authors.initials: G
authors.lastname: Kao
mesh_terms: D000328:Adult; D016863:Bacillaceae Infections / Q000175:diagnosis / Q000209:etiology*; D001409:Bacillus cereus / Q000502:physiology*; D001788:Blood Grouping and Crossmatching; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D061349:Unrelated Donors