title: Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release.
abstract: "Click and Photo-unclick Chemistry" of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.
authors.affiliation: Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, OK 73117, USA.
authors.forename: Moses
authors.initials: M
authors.lastname: Bio
authors.forename: Gregory
authors.initials: G
authors.lastname: Nkepang
authors.forename: Youngjae
authors.initials: Y
authors.lastname: You
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D008027:Light; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D017319:Photosensitizing Agents / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D000179:Acrylates; D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D017319:Photosensitizing Agents; D026082:Singlet Oxygen