title: Taurine plays an important role in the protection of spermatogonia from oxidative stress.
abstract: It has been demonstrated that taurine has various physiological functions in the body. We demonstrated that taurine is abundant in the serum, liver, muscle and testis of the Japanese eel (Anguilla japonica). In the eel testis, taurine is found mainly in spermatogonia and is weakly expressed also in the Sertoli cells. We have further found in the eel testis that taurine is actively accumulated via the sodium/chloride-dependent taurine transporter (TauT; SLC6A6), which is expressed in germ cells. In our current study, the effects of taurine on the anti-oxidant response were examined. Taurine was found to promote the total superoxide dismutase (SOD) activity in the testis. Moreover, our results indicate that taurine does not affect the mRNA levels of copper-zinc (Cu/Zn) SOD or manganese SOD, but promotes the translation of Cu/Zn SOD. Overall, our present data suggest that taurine may modulate Cu/Zn SOD at the translational level and thereby may play an important role in the protection of germ cells from oxidative stress.
authors.affiliation: Research Group for Reproductive Physiology, South Ehime Fisheries Research Center, Ehime University, Ainan, Ehime, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Higuchi
authors.forename: Fritzie T
authors.initials: FT
authors.lastname: Celino
authors.forename: Sonoko
authors.initials: S
authors.lastname: Shimizu-Yamaguchi
authors.forename: Chiemi
authors.initials: C
authors.lastname: Miura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miura
mesh_terms: D000818:Animals; D004524:Eels; D008297:Male; D009924:Organ Culture Techniques; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013093:Spermatogonia / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*
chemical_list: D012333:RNA, Messenger; D013654:Taurine; D013482:Superoxide Dismutase