title: [Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease].
abstract: OBJECTIVE
  To examine the relationships between the level of serum visfatin and obesity, nonalcoholic fatty liver disease (NAFLD) in children and adolescents.
  
  
  METHODS
  Serum visfatin levels of 106 obese children/adolescents (including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones, 15 moderate-to-severe ones) with another 69 lean children/adolescents as their controls, were examined by indirect sandwich ELISA.
  
  
  RESULTS
  When comparing the serum visfatin levels, there was no significant difference noticed between the obese group (1.71±0.37) ng/ml and the lean group (1.75±0.37) ng/ml (P=0.455). With the severity of NAFLD, the serum visfatin level showed an elevation in obese children and adolescents [obese without NAFLD (1.59±0.36) ng/ml, obese with mild NAFLD (1.74±0.36) ng/ml, obese with moderate-to-severe NAFLD (1.97±0.36) ng/ml, P<0.05]. In the obese group, serum visfatin levels seemed to be related to age (β=-0.326, P=0.000), alanine aminotransferase (ALT) (β=0.286, P=0.004) and the degree of NAFLD (β=0.246, P=0.014).
  
  
  CONCLUSIONS
  The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent.
authors.affiliation: Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wen
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005234:Fatty Liver / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D065626:Non-alcoholic Fatty Liver Disease; D063766:Pediatric Obesity / Q000097:blood*
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase