title: In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species.
abstract: The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.
authors.affiliation: VAMC, Syracuse, New York, USA. michael.cynamon@med.va.gov
authors.forename: Michael
authors.initials: M
authors.lastname: Cynamon
authors.forename: Jeff
authors.initials: J
authors.lastname: Jureller
authors.forename: Balaji
authors.initials: B
authors.lastname: Desai
authors.forename: Krithika
authors.initials: K
authors.lastname: Ramachandran
authors.forename: Mary
authors.initials: M
authors.lastname: Sklaney
authors.forename: Trudy H
authors.initials: TH
authors.lastname: Grossman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D019907:Mycobacterium fortuitum / Q000187:drug effects*; D009615:Nocardia / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents