title: Human renal cancer stem cells.
abstract: Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles.
authors.affiliation: Department of Internal Medicine, Research Center for Experimental Medicine and Molecular Biotechnology Center, University of Torino, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Bussolati
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dekel
authors.forename: Bruno
authors.initials: B
authors.lastname: Azzarone
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D002454:Cell Differentiation; D000071063:Endoglin; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D019409:Interleukin-15 / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D019409:Interleukin-15; D011956:Receptors, Cell Surface