title: Fetal microchimerism in skin wound healing.
abstract: Skin wound healing is a complex regenerative process involving various cell types. We recently investigated whether fetal microchimeric cells (FMCs) acquired during gestation contribute to maternal wound healing and used fetal microchimerism to investigate the recruitment of distant endothelial progenitor cells in skin wounds. Our study showed that fetal progenitor cells are recruited into maternal wounds and participate in inflammation and angiogenesis. These fetal cells might have beneficial effects in situations of maternal defective healing, and might also modify the adult maternal wound environment toward a scarless fetal-like wound healing.
authors.affiliation: Université Pierre et Marie Curie; Paris, France. dany.nassar@inserm.fr
authors.forename: Dany
authors.initials: D
authors.lastname: Nassar
authors.forename: Kiarash
authors.initials: K
authors.lastname: Khosrotehrani
authors.forename: Selim
authors.initials: S
authors.lastname: Aractingi
mesh_terms: D000818:Animals; D046528:Chimerism; D017364:Collagenases / Q000235:genetics / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology; D005260:Female; D005333:Fetus / Q000166:cytology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018919:Neovascularization, Physiologic; D011247:Pregnancy; D012867:Skin / Q000098:blood supply / Q000293:injuries / Q000378:metabolism; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing
chemical_list: D053773:Transforming Growth Factor beta1; D017364:Collagenases; C417249:collagenase 1