title: Preoperative thrombocytosis is associated with survival after surgery for colorectal cancer.
abstract: OBJECTIVE
  To evaluate the influence of preoperative thrombocytosis on survival after surgery in patients with colorectal cancer (CRC).
  
  
  METHODS
  Four hundred fifty-three patients who had undergone CRC surgery were retrospectively identified from institutional database. On the basis of receiver operating characteristic (ROC) curve analysis, they were classified into two groups: group A, with a preoperative platelet count of ≤300 (×10(9) /L), and Group B, with a preoperative platelet count of >300 (×10(9) /L). Uni- and multivariate analyses were performed to evaluate the relationship to overall survival. Kaplan-Meier analysis and log rank test were used to compare the survival curves between groups A and B.
  
  
  RESULTS
  There was a significant difference in overall survival between the two groups (P = 0.007). Multivariate analysis of selected preoperative clinicolaboratory characteristics showed that overall survival was associated with the platelet count (Group A/B) (odds ratio, 1.642; 95% CI, 1.025-2.629; P = 0.039) as well as the number of tumors (1/≥2), and the serum levels of C-reactive protein (CRP) and carcinoembryonic antigen (CEA).
  
  
  CONCLUSIONS
  Preoperative thrombocytosis is associated with survival after surgery in CRC patients, and is able to divide such patients into two independent groups before surgery.
authors.affiliation: Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan. mm-ishizuka@umin.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagata
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Takagi
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012372:ROC Curve; D012189:Retrospective Studies; D015996:Survival Rate; D013922:Thrombocytosis / Q000150:complications* / Q000401:mortality / Q000473:pathology; D016896:Treatment Outcome