title: Recent advances in bioanalytical sample preparation for LC-MS analysis.
abstract: Sample preparation has historically been, and continues to be, the most challenging part of the bioanalytical workflow. Several techniques have been developed over the years to deal with the problems of recovery and matrix effects in an effort to increase the reliability and robustness of the bioanalytical method. In recent years certain techniques have come into prominence and gained acceptance in routine sample preparation, and some have shown promise in their use in a discovery environment where speed is critical and method development time is often limited. The aim of this review is to examine several of these techniques and provide examples of their use from the literature, as well as comment on their utility in current workflows.
authors.affiliation: Analytical Development, Momenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02141, USA. csingleton@momentapharma.com
authors.forename: Christopher
authors.initials: C
authors.lastname: Singleton
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D059625:Liquid-Liquid Extraction; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification; D010949:Plasma / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D052617:Solid Phase Microextraction
chemical_list: D004364:Pharmaceutical Preparations; D012492:Salts