title: Proteome reference map of Drosophila melanogaster head.
abstract: Drosophila melanogaster has been used as a genetic model organism to understand the fundamental molecular mechanisms in human biology including memory formation that has been reported involving protein synthesis and/or post-translational modification. In this study, we employed a proteomic platform based on fluorescent 2DE and MALDI-TOF MS to build a standard D. melanogaster head proteome map for proteome-proteome comparison. In order to facilitate the comparison, an interactive database has been constructed for systematically integrating and analyzing the proteomes from different conditions and further implicated to study human diseases related to D. melanogaster model. In summary, the fundamental head proteomic database and bioinformatic analysis will be useful for further elucidating the biological mechanisms such as memory formation and neurodegenerative diseases.
authors.affiliation: Department of Medical Sciences, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Tian-Ren
authors.initials: TR
authors.lastname: Lee
authors.forename: Shun-Hong
authors.initials: SH
authors.lastname: Huang
authors.forename: Chi-Ching
authors.initials: CC
authors.lastname: Lee
authors.forename: Hsiao-Yun
authors.initials: HY
authors.lastname: Lee
authors.forename: Hsin-Tzu
authors.initials: HT
authors.lastname: Chan
authors.forename: Kuo-Sen
authors.initials: KS
authors.lastname: Lin
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Chan
authors.forename: Ping-Chiang
authors.initials: PC
authors.lastname: Lyu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030562:Databases, Protein; D029721:Drosophila Proteins / Q000737:chemistry; D004331:Drosophila melanogaster / Q000737:chemistry*; D006257:Head; D020543:Proteome / Q000737:chemistry; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D029721:Drosophila Proteins; D020543:Proteome