title: Definitive radiotherapy for early stage glottic cancer by 6 MV photons.
abstract: OBJECTIVE
  To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.
  
  
  METHODS
  We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.
  
  
  RESULTS
  The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.Poorly differentiated histology and tumor biologically effective dose<65 Gy15 were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.
  
  
  CONCLUSIONS
  Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.
authors.affiliation: Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, China. chichungtong@hkcr.org
authors.forename: Chi-Chung
authors.initials: CC
authors.lastname: Tong
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Au
authors.forename: Roger Kai-Cheong
authors.initials: RK
authors.lastname: Ngan
authors.forename: Foon-Yiu
authors.initials: FY
authors.lastname: Cheung
authors.forename: Sin-Ming
authors.initials: SM
authors.lastname: Chow
authors.forename: Yiu-Tung
authors.initials: YT
authors.lastname: Fu
authors.forename: Joseph Siu-Kei
authors.initials: JS
authors.lastname: Au
authors.forename: Stephen Chun-Key
authors.initials: SC
authors.lastname: Law
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017785:Photons / Q000627:therapeutic use*; D012189:Retrospective Studies; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome