title: Planar cell polarity genes, Celsr1-3, in neural development.
abstract: flamingo is among the 'core' planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1-3, are widely expressed in the nervous system. Recent work has shown that Celsr1-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.
authors.affiliation: Joint Laboratory for Brain Function and Health, Jinan University and The University of Hong Kong, Medical School of Jinan University, Guangzhou 510632, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Feng
authors.forename: Qi
authors.initials: Q
authors.lastname: Han
authors.forename: Libing
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D016764:Cell Polarity / Q000235:genetics*; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology
chemical_list: D015820:Cadherins; C117380:Celsr1 protein, mouse; C498478:Celsr2 protein, mouse; C444454:Celsr3 protein, mouse; D029721:Drosophila Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C121420:stan protein, Drosophila