title: Central corneal thickness in Iranian congenital glaucoma patients.
abstract: OBJECTIVE
  To compare central corneal thickness (CCT) in subjects with controlled primary congenital glaucoma (PCG) and nonglaucomatous subjects and to investigate the correlation between CCT and intraocular pressure (IOP) in the study population.
  
  
  METHODS
  Twenty-three consecutive PCG cases with controlled IOP and no clinical evidence of corneal edema comprised the Study Group. There was an interval of at least 2 months between last intraocular surgery and inclusion in the study. Twenty-one subjects with strabismus or lacrimal drainage insufficiency who did not have glaucoma or any history of intraocular surgery or ocular trauma comprised the control group. The Control Group was age and sex-matched. Data from ultrasonic pachymetry and applanation tonometry were analyzed for differences between groups. Correlation of the study parameters was investigated. A P-value less than 0.05 was statistically significant.
  
  
  RESULTS
  Data from both eyes of subjects in the Study Group and Control Group were included in the original analysis. Mean CCT was statistically significantly higher in the Study Group compared to the Control Group (589.42 ± 53.44 μm vs. 556.14 ± 30.51 μm, respectively; P=0.001). There was a significant correlation between CCT and IOP (r=0.63; P<0.0001). Similar statistically significant outcomes were observed when only one eye per subject was used in a reanalysis of the data for the Study and Control Groups.
  
  
  CONCLUSIONS
  Patients with PCG who had controlled IOP have statistically significantly thicker corneas than nonglaucomatous age and sex-matched subjects The thicker cornea could significantly alter IOP measurement with applanation tonometry. Pachymetry should be considered an essential part of the evaluation for PCG.
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Heidar
authors.initials: H
authors.lastname: Amini
authors.forename: Ghasem
authors.initials: G
authors.lastname: Fakhraie
authors.forename: Sara
authors.initials: S
authors.lastname: Abolmaali
authors.forename: Nima
authors.initials: N
authors.lastname: Amini
authors.forename: Ramin
authors.initials: R
authors.lastname: Daneshvar
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure; D007492:Iran / Q000453:epidemiology; D008297:Male; D033401:Microscopy, Acoustic; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult