title: The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea.
abstract: Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.
authors.affiliation: University of California, San Francisco, San Francisco, CA 94110, USA. wualan@labmed2.ucsf.edu
authors.forename: Alan H B
authors.initials: AH
authors.lastname: Wu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tabas
authors.forename: Johnathan
authors.initials: J
authors.lastname: Stein
authors.forename: Mihael
authors.initials: M
authors.lastname: Potocki
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
authors.forename: James
authors.initials: J
authors.lastname: McCord
authors.forename: Mark
authors.initials: M
authors.lastname: Richards
authors.forename: Oliver
authors.initials: O
authors.lastname: Hartmann
authors.forename: Richard
authors.initials: R
authors.lastname: Nowak
authors.forename: W Frank
authors.initials: WF
authors.lastname: Peacock
authors.forename: Piotr
authors.initials: P
authors.lastname: Ponikowski
authors.forename: Martin
authors.initials: M
authors.lastname: Moeckel
authors.forename: Christopher
authors.initials: C
authors.lastname: Hogan
authors.forename: Gerasimos S
authors.initials: GS
authors.lastname: Filippatos
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Somma
authors.forename: Inder
authors.initials: I
authors.lastname: Anand
authors.forename: Leong
authors.initials: L
authors.lastname: Ng
authors.forename: Sean-Xavier
authors.initials: SX
authors.lastname: Neath
authors.forename: Robert
authors.initials: R
authors.lastname: Christenson
authors.forename: Nils G
authors.initials: NG
authors.lastname: Morgenthaler
authors.forename: Stefan D
authors.initials: SD
authors.lastname: Anker
authors.forename: Alan S
authors.initials: AS
authors.lastname: Maisel
mesh_terms: D000208:Acute Disease; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D004417:Dyspnea / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C574167:mid-regional pro-adrenomedullin, human; C552580:midregional pro-atrial natriuretic peptide, human; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor