title: Retinoblastoma in the perinatal and neonatal child.
abstract: Retinoblastoma is a rare primary intraocular malignancy. Presentation in the neonatal period is not common. With improved genetic testing, screening of the unborn child and neonate is taking on a greater role in the management of these patients. Treatment of retinoblastoma in the neonate is complex and requires a multidisciplinary and highly individualized approach. If possible, focal modalities should be used and external beam radiation avoided. Systemic intravenous chemotherapy may be necessary with regimens including carboplatin, vincristine and etoposide. Such cases are best managed by specialist centers with access to experts in oncology, ophthalmology, radiation therapy, genetics, pathology and anesthesia.
authors.affiliation: M.D. Anderson Cancer Center, Texas Children's Cancer Center, The Methodist Hospital Research Institute, Baylor College of Medicine, 1515 Holcombe Boulevard, Unit 1445, Houston, Texas 77030-4009, USA. Electronic address: dgombos@mdanderson.org.
authors.forename: Dan S
authors.initials: DS
authors.lastname: Gombos
mesh_terms: D000328:Adult; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012175:Retinoblastoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D016160:Retinoblastoma Protein