title: Unilateral presentation of pseudo-Kaposi's acroangiodermatitis--a diagnostic and therapeutic challenge.
abstract: BACKGROUND
  Acroangiodermatitis is a rare skin disease characterised by hyperplasia of pre-existing vasculature due to venous hypertension from severe chronic venous stasis. Clinical appearance of this condition is often similar to Kaposi sarcoma and is creating serious differential diagnostic difficulties.
  
  
  METHODS
  A patient with acroangiodermatitis was presented and the differential diagnosis discussed. Examination of the patella of the affected area showed grayish-blue to brown infiltrates and reduced elasticity, located in the supra- and infrapatellar regions. Clinically, Kaposi's sarcoma was suspected. Histopathologically there were acanthosis and compact hyperkeratosis. The underlying papillary dermis showed fibrosis and edema. A subepidermal lobular vascular proliferation with hemosiderin deposition was also noted. This consisted of multiple newly formed capillaries, featuring small blood vessels with dilated, rounded lumina. Serologies for HIV and Borrelia burgdorferi were negative, as was a HHV-8 PCR in lesional tissue. Doppler analysis of the vessels of the extremities showed chronic venous insufficiency, insufficiency of v. perforantes, insufficiency of the Cockett II-III. No deep thromboses in the area of the shank and thigh were found. Initially, treatment consisted of clindamycin 600 mg 3 times per day, intravenously, during a 2-week period. After that the treatment was continued with prednisolone, 30 mg daily in combination with furosemide 40 mg/day, as well as lymph drainage and adequate compression therapy. The consequent clinical improvement allowed the patient to be discharged from the clinic.
  
  
  CONCLUSIONS
  The most important differential diagnostic marker in distinguishing between acroangiodermatitis and Kaposi sarcoma seems to be the confirmation of the presence of genetic material of HHV-8 in the affected skin areas in patients with Kaposi sarcoma.
authors.affiliation: Polyclinic of Dermatology and Venerology, University Hospital Lozenetz, Medical Faculty, Saint Kliment Ohridski University, Sofia, Bulgaria. gtchernev@yahoo.de
authors.forename: Georgi
authors.initials: G
authors.lastname: Tchernev
authors.forename: James W
authors.initials: JW
authors.lastname: Patterson
authors.forename: Julian
authors.initials: J
authors.lastname: Ananiev
authors.forename: Michael
authors.initials: M
authors.lastname: Tronnier
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology; D017445:Skin Diseases, Vascular / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology