title: The study of soluble intercellular adhesion molecule-1 and ghrelin in adolescents with family history of type 2 diabetes.
abstract: The purpose of this study was to observe both the changes of soluble intercellular adhesion molecule-1 (sICAM-1) and ghrelin in adolescents with family history of type 2 diabetes (FHD) and the relationship between sICAM-1 and ghrelin. This case-control study included 63 adolescents (boys/girls 29/34, age 14.1 ± 0.7 years) without FHD (FHD-) and 67 adolescents (boys/girls 33/34, age 14.0 ± 0.8 years) with FHD (FHD+). Anthropometric measurements, including height, weight, waist circumference (WC), and blood pressure, were obtained. Blood samples were collected, and fasting plasma glucose (FPG), serum lipids, true insulin, sICAM-1, and ghrelin were assayed. The results showed that the age and gender were similar in two groups (P > 0.05). Body mass index (BMI), WC, FPG, fasting insulin, HOMA-IR, and sICAM-1 were all significantly higher in the FHD+ group than in the FHD- group (P < 0.05). Ghrelin was significantly lower in the FHD+ group than in the FHD- group (P < 0.05). sICAM-1 was positively correlated with WC (r = 0.178, P = 0.043), fasting insulin (r = 0.195, P = 0.026), HOMA-IR (r = 0.197, P = 0.024), and ghrelin (r = 0.290, P = 0.001). After multivariate analysis, the ghrelin (β = 0.788, 95 % CI: 0.416-1.159, P = 0.000) and HOMA-IR (β = 0.106, 95 % CI: 0.045-0.167, P = 0.001) maintained an independent association with sICAM-1. These findings led to the conclusion that endothelial dysfunction and decline of ghrelin were found in adolescents with family history of diabetes. The decline of ghrelin maybe a protection mechanism for endothelial function in adolescents with family history of diabetes and should be examined in future studies.
authors.affiliation: Department of Endocrinology, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, 066000, Hebei, China. liubo_wei@126.com
authors.forename: Bo-Wei
authors.initials: BW
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Ma
authors.forename: Jun-Ru
authors.initials: JR
authors.lastname: Liu
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Lou
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Liu
authors.forename: Fu-Zai
authors.initials: FZ
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D005260:Female; D054439:Ghrelin / Q000097:blood* / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000235:genetics*; D008297:Male; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D055105:Waist Circumference
chemical_list: D054439:Ghrelin; D018799:Intercellular Adhesion Molecule-1