title: Robotic gait training is not superior to conventional treadmill training in parkinson disease: a single-blind randomized controlled trial.
abstract: BACKGROUND
  The use of robots for gait training in Parkinson disease (PD) is growing, but no evidence points to an advantage over the standard treadmill.
  
  
  METHODS
  In this randomized, single-blind controlled trial, participants aged <75 years with early-stage PD (Hoehn-Yahr <3) were randomly allocated to 2 groups: either 30 minutes of gait training on a treadmill or in the Lokomat for 3 d/wk for 4 weeks. Patients were evaluated by a physical therapist blinded to allocation before and at the end of treatment and then at the 3- and 6-month follow-up. The primary outcome measure was the 6-minute walk test.
  
  
  RESULTS
  Of 334 screened patients, the authors randomly allocated 30 to receive gait training with treadmill or the Lokomat. At baseline, the 2 groups did not differ. At the 6-month follow-up, both groups had improved significantly in the primary outcome measure (treadmill: mean = 490.95 m, 95% confidence interval [CI] = 448.56-533.34, P = .0006; Lokomat: 458.6 m, 95% CI = 417.23-499.96, P = .01), but no significant differences were found between the 2 groups (P = .53).
  
  
  CONCLUSIONS
  Robotic gait training with the Lokomat is not superior to treadmill training in improving gait performance in patients with PD. Both approaches are safe, with results maintained for up to 6 months.
authors.affiliation: Azienda Ospedaliero-Universitaria, Novara, Italy. stefano.carda@chuv.ch
authors.forename: Stefano
authors.initials: S
authors.lastname: Carda
authors.forename: Marco
authors.initials: M
authors.lastname: Invernizzi
authors.forename: Alessio
authors.initials: A
authors.lastname: Baricich
authors.forename: Cristoforo
authors.initials: C
authors.lastname: Comi
authors.forename: Alexandre
authors.initials: A
authors.lastname: Croquelois
authors.forename: Carlo
authors.initials: C
authors.lastname: Cisari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005684:Gait / Q000502:physiology*; D020233:Gait Disorders, Neurologic / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000503:physiopathology / Q000534:rehabilitation*; D011446:Prospective Studies; D012371:Robotics / Q000379:methods*; D018401:Sample Size; D016037:Single-Blind Method; D016138:Walking / Q000502:physiology