title: The role of cGMP signalling in regulating life cycle progression of Plasmodium.
abstract: The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development. The current views on potential effector proteins downstream of PKG and the mechanisms that may regulate cyclic nucleotide levels are presented.
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Christine S
authors.initials: CS
authors.lastname: Hopp
authors.forename: Paul W
authors.initials: PW
authors.lastname: Bowyer
authors.forename: David A
authors.initials: DA
authors.lastname: Baker
mesh_terms: D006152:Cyclic GMP / Q000378:metabolism*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism*; D005786:Gene Expression Regulation; D010962:Plasmodium berghei / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D010963:Plasmodium falciparum / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D017869:Cyclic GMP-Dependent Protein Kinases; D006152:Cyclic GMP