title: Association between troponin T and ICU mortality, a changing trend.
abstract: BACKGROUND
  Initially elevated levels of troponin predict adverse outcomes in patients admitted to the intensive care unit (ICU). No research team has investigated the changes in concentration of cardiac troponin T (cTnT) during ICU stay and their association with patient outcome.
  
  
  OBJECTIVE
  We investigated whether the change in cTnT levels during ICU stay could predict outcomes (death or survival).
  
  
  METHODS
  In this cohort study, all patients admitted to the medical ICU (10 beds) from January to July 2008 were enrolled. Troponin levels were evaluated within the first 24 hours of ICU admission and on the fourth, seventh and 10th days after admission.
  
  
  RESULTS
  The study population (135 patients) had a mean age of 60.9 ± 21.5 years. The outcome was significantly different with regard to normal or elevated cTnT concentrations on the first and seventh days of follow up (p = 0.03 and 0.023, respectively). This difference was non-significant for cTnT levels on the fourth and 10th days after admission (p = 0.69 and 0.78, respectively). The change in cTnT levels was not significantly different between the deceased and discharged patients (p = 0.4).
  
  
  CONCLUSIONS
  Changes in cTnT levels during ICU stay did not show a significant trend (power: 0.26). Patients whose cTnT levels were increased on the first and seventh days of ICU stay had a worse survival, which could be associated with cardiac events on admission or at specific times during the stay in ICU.
authors.affiliation: Department of Cardiology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Hajsadeghi
authors.forename: S
authors.initials: S
authors.lastname: Gholami
authors.forename: G
authors.initials: G
authors.lastname: Gohardehi
authors.forename: N S
authors.initials: NS
authors.lastname: Moghadam
authors.forename: A S
authors.initials: AS
authors.lastname: Sabet
authors.forename: S R
authors.initials: SR
authors.lastname: Kerman
authors.forename: M
authors.initials: M
authors.lastname: Moradi
authors.forename: R
authors.initials: R
authors.lastname: Mollahoseini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D019210:Troponin I / Q000097:blood*; D055815:Young Adult
chemical_list: D019210:Troponin I