title: Microfibers fabricated by non-covalent assembly of peptide and DNA for viral vector encapsulation and cancer therapy.
abstract: Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.
authors.affiliation: Institute of Bioengineering and Nanotechnology, Singapore, Singapore.
authors.forename: Jingye
authors.initials: J
authors.lastname: Yang
authors.forename: Ghayathri
authors.initials: G
authors.lastname: Balasundaram
authors.forename: Seong-Loong
authors.initials: SL
authors.lastname: Lo
authors.forename: Eugene Choo Shi
authors.initials: EC
authors.lastname: Guang
authors.forename: Jun Min
authors.initials: JM
authors.lastname: Xue
authors.forename: Jianxing
authors.initials: J
authors.lastname: Song
authors.forename: Andrew C A
authors.initials: AC
authors.lastname: Wan
authors.forename: Jackie Y
authors.initials: JY
authors.lastname: Ying
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D002214:Capsules; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics* / Q000378:metabolism; D005910:Glioma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D006801:Humans; D051379:Mice; D055616:Microtechnology / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D014161:Transduction, Genetic
chemical_list: D002214:Capsules; D004337:Drug Carriers; D010455:Peptides; D004247:DNA