title: Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
abstract: The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.
authors.affiliation: Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Horita
authors.forename: Takemasa
authors.initials: T
authors.lastname: Takii
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yagi
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogawa
authors.forename: Nagatoshi
authors.initials: N
authors.lastname: Fujiwara
authors.forename: Emi
authors.initials: E
authors.lastname: Inagaki
authors.forename: Laurent
authors.initials: L
authors.lastname: Kremer
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sato
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kuroishi
authors.forename: Yoosa
authors.initials: Y
authors.lastname: Lee
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Makino
authors.forename: Hajime
authors.initials: H
authors.lastname: Mizukami
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Kikuo
authors.initials: K
authors.lastname: Onozaki
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004221:Disulfiram / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D054908:Extensively Drug-Resistant Tuberculosis / Q000188:drug therapy / Q000382:microbiology*; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D004050:Ditiocarb; D004221:Disulfiram