title: Factors associated with bovine neonatal pancytopenia (BNP) in calves: a case-control study.
abstract: Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure® BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p<0.001) and its herd of origin being located in Scotland (OR 9.71, p = 0.006). Decreased odds of a calf being a BNP case were associated with the calf having been kept outside (OR 0.11, p = 0.006). The longer that a cattle herd had been established on the farm was also associated with decreased odds of a calf in that herd being a BNP case (OR 0.97, p = 0.011).
authors.affiliation: Animal Health and Veterinary Laboratories Agency, Addlestone, Surrey, England. sarah.lambton@ahvla.gsi.gov.uk
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Lambton
authors.forename: Adrian D
authors.initials: AD
authors.lastname: Colloff
authors.forename: Richard P
authors.initials: RP
authors.lastname: Smith
authors.forename: George L
authors.initials: GL
authors.lastname: Caldow
authors.forename: Sandra F E
authors.initials: SF
authors.lastname: Scholes
authors.forename: Kim
authors.initials: K
authors.lastname: Willoughby
authors.forename: Fiona
authors.initials: F
authors.lastname: Howie
authors.forename: Johanne
authors.initials: J
authors.lastname: Ellis-Iversen
authors.forename: Graham
authors.initials: G
authors.lastname: David
authors.forename: Alasdair J C
authors.initials: AJ
authors.lastname: Cook
authors.forename: Andrew
authors.initials: A
authors.lastname: Holliman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016022:Case-Control Studies; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology; D005260:Female; D016015:Logistic Models; D008297:Male; D010198:Pancytopenia / Q000209:etiology / Q000662:veterinary*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D006113:United Kingdom; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014765:Viral Vaccines