title: USP2a activation of MYC in prostate cancer.
abstract: Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA. bnelson@jhmi.edu
authors.forename: William G
authors.initials: WG
authors.lastname: Nelson
authors.forename: Angelo M
authors.initials: AM
authors.lastname: De Marzo
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Yegnasubramanian
mesh_terms: D010450:Endopeptidases / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D043222:Ubiquitin Thiolesterase
chemical_list: C489427:MYC protein, human; D035683:MicroRNAs; D016271:Proto-Oncogene Proteins c-myc; D010450:Endopeptidases; C108665:USP2 protein, human; D043222:Ubiquitin Thiolesterase