title: Modulation of DNA binding by reversible metal-controlled molecular reorganizations of scorpiand-like ligands.
abstract: DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.
authors.affiliation: Instituto de Ciencia Molecular, Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Valencia, Spain.
authors.forename: Mario
authors.initials: M
authors.lastname: Inclán
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Albelda
authors.forename: Juan C
authors.initials: JC
authors.lastname: Frías
authors.forename: Salvador
authors.initials: S
authors.lastname: Blasco
authors.forename: Begoña
authors.initials: B
authors.lastname: Verdejo
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.forename: Clàudia
authors.initials: C
authors.lastname: Salat-Canela
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Díaz
authors.forename: Antonio
authors.initials: A
authors.lastname: García-España
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology*; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D008670:Metals / Q000378:metabolism*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D011522:Protons; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D047028:Macrocyclic Compounds; D008670:Metals; D011522:Protons; D004247:DNA; C427203:calf thymus DNA