title: TP53 codon 72 polymorphism with hepatocellular carcinoma: a metaanalysis.
abstract: OBJECTIVE
  The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial. A metaanalysis was performed  in order to define this relationship more precisely.
  
  
  METHODS
  Published studies of TP53 codon 72 polymorphism and the risk of HCC were identified. Data were extracted, and summary odds ratios (OR) and 95% confidence intervals (95% CI) were calculated. Pooled ORs were determined for  an additive model (R/R versus P/P), a dominant model ([R/R + R/P] versus P/P) and a recessive model (R/R versus [R/P + P/P]).
  
  
  RESULTS
  The meta-analysis included seven case-control studies (total 1511 cases and 2165 controls). The risk of cancer was significantly decreased in the overall  dominant model and the dominant model in Asian populations. A significantly decreased risk was found for all models in hospital-based but not population-based studies. There was no association between polymorphism and cancer risk when data were stratified according to hepatitis B or C virus  infection status.
  
  
  CONCLUSIONS
  The TP53 codon 72 polymorphism may be a risk factor for HCC.
authors.affiliation: The Fourth Department of General Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: C
authors.initials: C
authors.lastname: Ding
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.forename: H
authors.initials: H
authors.lastname: Qin
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity; D000428:Alcohol Drinking / Q000009:adverse effects; D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D016604:Aflatoxin B1