title: Phenytoin for neuropathic pain and fibromyalgia in adults.
abstract: BACKGROUND
  Antiepileptic drugs have been used in pain management since the 1960s; some have shown efficacy in treating different neuropathic pain conditions. Phenytoin is an established antiepileptic drug that has been used occasionally to treat intractable trigeminal neuralgia.
  
  
  OBJECTIVE
  To assess the analgesic efficacy and adverse effects of the antiepileptic drug phenytoin in neuropathic pain and fibromyalgia.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 2), MEDLINE, and EMBASE to 28 February 2012, together with reference lists of retrieved papers and reviews, and ClinicalTrials.gov.
  
  
  METHODS
  We planned to include randomised, double-blind studies of eight weeks duration or longer, comparing phenytoin with placebo or another active treatment in chronic neuropathic pain or fibromyalgia.
  
  
  METHODS
  Two review authors would independently extract data for efficacy and adverse events, and examine issues of study quality.
  
  
  RESULTS
  We did not identify any studies that satisfied the inclusion criteria.
  
  
  CONCLUSIONS
  This review uncovered no evidence of sufficient quality to support the use of phenytoin in chronic neuropathic pain or fibromyalgia.
authors.affiliation: Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford,UK.
authors.forename: Fraser
authors.initials: F
authors.lastname: Birse
authors.forename: Sheena
authors.initials: S
authors.lastname: Derry
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Moore
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D005356:Fibromyalgia / Q000188:drug therapy*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D059408:Pain Management / Q000379:methods*; D010672:Phenytoin / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010672:Phenytoin