title: [Liver damage in the course of Langerhans cells histiocytosis--case report].
abstract: Langerhans cell histiocytosis is a disorder of unknown etiology characterized by proliferation of histiocytes originating from dendric cells. It usually affects children. LCH is claimed to be a difficult diagnostic challenge. We present a case of multi-organ LCH with severe liver damage. Initial symptoms of disease, the results of additional tests including histological assessment of liver suggested an autoimmune hepatitis. Histopathological evaluation of sequentially occurring lesions in the intestines and lungs made it possible to clarify the diagnosis. As there is no effective treatment--the progression of the disease resulted in patient being qualified for liver transplantation.
authors.affiliation: Department of Infectious Diseases and Hepathology, Medical University of Bialystok, Poland. pk.kozlowski@wp.pl
authors.forename: Paweł
authors.initials: P
authors.lastname: Kozłowski
authors.forename: Tadeusz Wojciech
authors.initials: TW
authors.lastname: Łapiński
authors.forename: Robert
authors.initials: R
authors.lastname: Flisiak
mesh_terms: D000328:Adult; D018450:Disease Progression; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016031:Liver Transplantation; D008297:Male