title: The protective role of Aegle marmelos on aspirin-induced gastro-duodenal ulceration in albino rat model: a possible involvement of antioxidants.
abstract: OBJECTIVE
  Gastro duodenal ulcer is a common disorder of the gastrointestinal tract. Several Indian medicinal plants have been traditionally and extensively used to prevent different diseases. In the present research studies, Bael fruit (Aegle marmelos (AM), family: Rutaceae) which are also called as Bilva in ancient Sanskrit was used as a herbal drug and its antioxidative role in aspirin- induced gastroduodenal ulceration in albino rat was evaluated using essential biochemical parameters.
  
  
  METHODS
  Mucosal thickness (MT), ulcer index (UI), different biochemical parameters, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and lipid peroxidation (LPO) were measured in all the groups, to study the possible involvement of antioxidants with gastroduodenal protection.
  
  
  RESULTS
  A significant decrease in MT, SOD and CAT activities and GSH level and a significant increase in UI, AST, ALT, and ALP activities and LPO level were observed in aspirin treated stomach and duodenum of albino rats.
  
  
  CONCLUSIONS
  Pretreatment with AM fruit pulp extract for 14 consecutive days showed the reverse effects of aspirin suggesting gastro-duodenal protective and anti- ulcerogenic properties of AM through its antioxidant mechanism.
authors.affiliation: Department of Physiology, Katwa College, University of Burdwan, Burdwan, West Bengal, India.
authors.forename: Shyamal K
authors.initials: SK
authors.lastname: Das
authors.forename: Chandan
authors.initials: C
authors.lastname: Roy
mesh_terms: D045471:Aegle; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001241:Aspirin / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology; D007413:Intestinal Mucosa / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D001241:Aspirin