title: A new triterpenoid saponin from Glinus oppositifolius with α-glucosidase inhibitory activity.
abstract: Evaluation of α-glucosidase inhibitory activity led to the isolation of six triterpene saponins from the aerial parts of Glinus oppositifolius including one new and five known constituents. The structure of the new saponin, glinoside C (1), was established as 16-O-(β-D-glucopyranosyl)-3β,12β,16β,21α,22-pentahydroxy hopane by extensive use of 1-D, 2-D NMR and mass spectral techniques. The other constituents identified were 3-O-(β-D-xylopyranosyl)-spergulagenin A (2), spergulacin (3), spergulin A (4), spergulacin A (5) and spergulin B (6). Compound 1 exhibited the greatest inhibition of the enzyme with IC50 of 127 ± 30 µM. Kinetics study for the compound 1 demonstrated mixed type of inhibition (Ki = 157.9 µM).
authors.affiliation: Department of Natural Products , National Institute of Pharmaceutical Education and Research, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.forename: Vrunda
authors.initials: V
authors.lastname: Shah
authors.forename: Rina
authors.initials: R
authors.lastname: Ghosh
authors.forename: Bikas C
authors.initials: BC
authors.lastname: Pal
mesh_terms: D065089:Glycoside Hydrolase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035704:Molluginaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D012503:Saponins; D014315:Triterpenes