title: Gianotti-Crosti syndrome: a case report in an adult.
abstract: Gianotti-Crosti syndrome (GCS) is a viral-associated eruption that most commonly occurs in children aged 15 months to 2 years. It consists of monomorphic red-brown to pink papules and vesicles distributed symmetrically on the cheeks, extensor surface of the extremities, and buttocks. The eruption usually spontaneously resolves over the course of 10 to 60 days. We report the rare case of GCS in an adult. An otherwise healthy 20-year-old woman presented with a pruritic eruption of 2 weeks' duration on the dorsal aspect of her hands and feet, elbows, and knees. The patient received oral corticosteroids prior to presentation to our clinic with some improvement. A biopsy revealed histopathologic findings consistent with a diagnosis of GCS. The patient's aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were elevated. Over the course of the next 2 months, the patient's skin findings completely resolved with normalization of liver function tests. The clinical and histologic correlation was consistent with GCS in an adult. This condition may not be as rare in adults as previously thought. Clinicians should keep GCS in their differential diagnosis when examining adult patients.
authors.affiliation: Department of Dermatology, University of Rochester Medical Center, New York, USA. Luciano.J.Iorizzo@gmail.com
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Iorizzo
authors.forename: Glynis
authors.initials: G
authors.lastname: Scott
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Tausk
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis* / Q000188:drug therapy*; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids