title: Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design.
abstract: OBJECTIVE
  Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects.
  
  
  METHODS
  Diclofenac sodium loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation. Particle size, drug release, swelling, FTIR and SEM analyses were performed.
  
  
  RESULTS
  Optimized microbeads showed particle size of 0.589±0.054 to 0.620±0.067 mm, and drug entrapment efficiency of 97.88±2.86 to 98.60±3.55%. The in vitro drug release from microbeads was sustained over 10 hrs and followed controlled-release pattern. FTIR analysis indicated the possibility of intermolecular hydrogen bonding interactions, i.e., -OH…O=C in microbeads.
  
  
  CONCLUSIONS
  Microbeads for oral controlled delivery of diclofenac sodium were successfully developed by ionotropic gelation.
authors.affiliation: Department of Pharmaceutics.
authors.forename: Ak
authors.initials: A
authors.lastname: Nayak
authors.forename: S
authors.initials: S
authors.lastname: Khatua
authors.forename: Ms
authors.initials: M
authors.lastname: Hasnain
authors.forename: Kk
authors.initials: K
authors.lastname: Sen