title: The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus.
abstract: BACKGROUND
  We investigated whether the coronary artery disease (CAD) locus on chromosome 9p21 (as represented by single nucleotide polymorphism rs2383206) is associated with low estimated glomerular filtration rate (eGFR) or increased urinary albumin excretion in patients with Type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Four samples, including a total of 3167 patients, were studied. The presence of low eGFR (<60 mL/min/1.73m(2)) was estimated from serum creatinine by means of the Modification of Diet in Renal Disease Study equation. Increased urinary albumin excretion was defined as an albumin-creatinine ratio (ACR) ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women.
  
  
  RESULTS
  No association was found between rs2383206 and low eGFR or increased ACR in each sample as well as in a pooled analysis (overall odds ratio = 1.07, 95% confidence interval 0.94-1.22, P = 0.31 and overall odds ratio = 1.00, 95% confidence interval 0.90-1.12, P = 0.95, respectively). No interaction was observed between rs2383206 and poor glycemic control [HbA1c was above the median in the pooled sample (7.7%) in modulating eGFR or ACR (P for interaction = 0.42 and 0.90, respectively)].
  
  
  CONCLUSIONS
  Variability at the 9p21 CAD locus is unlikely to play a role in modulating susceptibility to kidney dysfunction in patients with T2DM.
authors.affiliation: Department of Medical Sciences, IRCSS Casa Sollievo della Sofferenza—Clinical Unit of Endocrinology, San Giovanni Rotondo, Italy. sdecosm@tin.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Cosmo
authors.forename: Sabrina
authors.initials: S
authors.lastname: Prudente
authors.forename: Olga
authors.initials: O
authors.lastname: Lamacchia
authors.forename: Daniela
authors.initials: D
authors.lastname: Lucchesi
authors.forename: Hetal
authors.initials: H
authors.lastname: Shah
authors.forename: Christine
authors.initials: C
authors.lastname: Mendonca
authors.forename: Laura
authors.initials: L
authors.lastname: Pucci
authors.forename: Luana
authors.initials: L
authors.lastname: Mercuri
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Gervino
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Hauser
authors.forename: Diego
authors.initials: D
authors.lastname: Bailetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Penno
authors.forename: Mauro
authors.initials: M
authors.lastname: Cignarelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Doria
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Trischitta
mesh_terms: D000419:Albuminuria / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000235:genetics*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D020641:Polymorphism, Single Nucleotide