title: Apolipoprotein B secretory regulation by degradation.
abstract: In this short review, we discuss apolipoprotein B100 and the assembly of very low-density lipoproteins. In particular, we address the nature and importance of co- and posttranslational degradation of apolipoprotein B100 during the assembly process. We also provide a short historical background to the development of the current model for the degradation of apolipoprotein B100.
authors.affiliation: Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Sven-Olof
authors.initials: SO
authors.lastname: Olofsson
authors.forename: Jan
authors.initials: J
authors.lastname: Borén
mesh_terms: D000818:Animals; D053299:Apolipoprotein B-100 / Q000097:blood / Q000266:history / Q000378:metabolism*; D035843:Biomedical Research / Q000266:history; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021381:Protein Transport
chemical_list: D053299:Apolipoprotein B-100; D008079:Lipoproteins, VLDL; D046988:Proteasome Endopeptidase Complex