title: Antimicrobial activity of some Clerodendrum species from Egypt.
abstract: Chloroformic and methanolic extracts of four Clerodendrum species cultivated in Egypt were screened for antimicrobial activities. Chloroformic extracts of the flowers of Clerodendrum chinense and Clerodendrum splendens were active against Plasmodium falciparum (IC50 < 10 µg mL(-1)). Chloroformic extracts of the stem and flowers of C. chinense were active against Trypanosoma cruzi (IC50 = 1.21 and 1.12 µg mL(-1), respectively) with marginal cytotoxicity. Chloroformic extracts of the leaves of C. chinense and C. splendens showed promising activities against T. cruzi (IC50 = 3.39 and 1.98 µg mL(-1), respectively) without cytotoxic effect on a human cell line. None of the selected plants showed significant activity against Gram-negative or Gram-positive bacteria or Candida albicans. Verbascoside, a phenyl propanoid glycoside isolated from the leaves of C. chinense, showed marginal activity against T. cruzi. Rengyolone, a cyclohexyl ethanoid isolated from the leaves of C. chinense, showed a broad but not specific activity against the tested organisms.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
authors.forename: Sameh F
authors.initials: SF
authors.lastname: Abouzid
authors.forename: Haytham M
authors.initials: HM
authors.lastname: Wahba
authors.forename: Ali
authors.initials: A
authors.lastname: Elshamy
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.forename: Sandra
authors.initials: S
authors.lastname: Apers
authors.forename: Luc
authors.initials: L
authors.lastname: Pieters
authors.forename: Abdelaaty A
authors.initials: AA
authors.lastname: Shahat
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032409:Clerodendrum / Q000737:chemistry*; D004534:Egypt; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts