title: Cortical circuits: layer 6 is a gain changer.
abstract: Stimulation of excitatory cells in layer six of mouse visual cortex results in net inhibition of the spiking of neurons in upper cortical layers; this ascending intra-cortical drive provides a mechanism for gain modulation of sensory-evoked responses.
authors.affiliation: The National Institute for Medical Research, The Ridgeway, London, UK.
authors.forename: Mateo
authors.initials: M
authors.lastname: Vélez-Fort
authors.forename: Troy W
authors.initials: TW
authors.lastname: Margrie
mesh_terms: D000818:Animals; D051379:Mice; D008959:Models, Neurological; D019579:Neocortex / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D013787:Thalamic Nuclei / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*