title: Unraveling the role of hypoxia-inducible factor in renal cell carcinoma: a biological and therapeutic perspective.
abstract: The genetic control of hypoxia-inducible factor (HIF) has long been associated with the pathogenesis of clear cell renal cell carcinoma. Only recently have the complex genetics and biology of relevant HIF subtypes been unraveled, leading to potential novel strategies for treating this disease.
authors.affiliation: Division of Genitourinary Malignancies, Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
authors.forename: Sumanta Kumar
authors.initials: SK
authors.lastname: Pal
authors.forename: Robert A
authors.initials: RA
authors.lastname: Figlin
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D016147:Genes, Tumor Suppressor; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D007680:Kidney Neoplasms / Q000235:genetics*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit