title: Vitamin B(12) Deficiency and Multiple Sclerosis; Is there Any Association?
abstract: BACKGROUND
  Vitamin B(12) (Cobalamin) deficiency can result in some clinical and paraclinical characteristics similar to what is seen in multiple sclerosis (MS) patients. This study aimed to evaluate the controversial association between vitamin B(12) deficiency and MS.
  
  
  METHODS
  We measured serum vitamin B(12) in 60 patients with MS and 38 healthy controls. Clinical disability was evaluated according to the Extended Disability Status Scale (EDSS). Serum B(12) concentration was measured with Radioimmunoassay Dual Isotope method. The cutoff value for low serum vitamin B(12) concentrations was 75 pg/mL. Patients were in remission at the time of blood draw.
  
  
  RESULTS
  There were 13 (21.6%) MS patients and 10 (26.3%) controls with low serum B(12) concentration with no significant difference between the groups; P>0.05. The mean serum vitamin B(12) concentration in MS patients (108.9±45.3 pg/mL) was not significantly different compared with controls (98.9±44.4 pg/mL); P=0.284. Likewise, there was no correlation between the concentration of serum vitamin B(12) and disease' age of onset, duration, subtypes, or disability status.
  
  
  CONCLUSIONS
  In contrast to some previous reports, our findings did not support any association between B(12) deficiency and MS.
authors.affiliation: Department of Neurology and Isfahan Neuroscience Research Center, Isfahan, Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Najafi
authors.forename: Vahid
authors.initials: V
authors.lastname: Shaygannajad
authors.forename: Maryam
authors.initials: M
authors.lastname: Mirpourian
authors.forename: Ali
authors.initials: A
authors.lastname: Gholamrezaei