title: Electrophilic trifluoromethylation by copper-catalyzed addition of CF3-transfer reagents to alkenes and alkynes.
abstract: Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of CuI, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.
authors.affiliation: Department of Organic Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Pär G
authors.initials: PG
authors.lastname: Janson
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ghoneim
authors.forename: Nadia O
authors.initials: NO
authors.lastname: Ilchenko
authors.forename: Kálmán J
authors.initials: KJ
authors.lastname: Szabó
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D003300:Copper; D007455:Iodine