title: Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties.
abstract: Here, dual-modal bioprobes for combined optical and magnetic resonance (MR) imaging are reported. Gadolinium orthophosphate (GdPO(4)) nanorods co-doped with light-emitting lanthanide ions have been successfully prepared through a hydrothermal method. An efficient downconversion luminescence from Ce/Tb or Eu doped GdPO(4) nanorods and upconversion luminescence from Yb/Er co-doped GdPO(4) nanorods are observed, respectively, which offers the optical modality for the nanoprobes. Notably, we first report the upconversion phenomenon based on the GdPO(4) matrix under 980 nm near infrared irradiation. The possibility of using these nanoprobes with downconversion and upconversion luminescent emissions for optical cell imaging is also demonstrated. Furthermore, these Gd(3+)-containing nanophosphors show good positive signal-enhancement ability when performed under a 4.7 T MR imaging scanner, indicating they have potential as T(1) MR imaging contrast agents. Thus, nanoprobes based on GdPO(4) nanophosphors are shown to provide the dual modality of optical and MR imaging.
authors.affiliation: Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Wenlu
authors.initials: W
authors.lastname: Ren
authors.forename: Gan
authors.initials: G
authors.lastname: Tian
authors.forename: Liangjun
authors.initials: L
authors.lastname: Zhou
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.forename: Shan
authors.initials: S
authors.lastname: Jin
authors.forename: Yan
authors.initials: Y
authors.lastname: Zu
authors.forename: Shoujian
authors.initials: S
authors.lastname: Li
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007477:Ions / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure
chemical_list: D003287:Contrast Media; D007477:Ions; D028581:Lanthanoid Series Elements; D005682:Gadolinium