title: Rotamers or diastereomers? An overlooked NMR solution.
abstract: The existence of rotamers in a solution of analyte complicates (1)H NMR analysis, especially when the presence of diastereomers is also possible. Organic chemists have often responded to this problem by conducting variable-temperature (VT) NMR experiments, changing NMR solvents, or adding complexing agents. Here, with specific examples, we illustrate the use of simple yet widely overlooked chemical-exchange NMR experiments which allow the nonintrusive rapid distinguishment of rapidly equilibrating small molecules such as rotamers from nonequilibrating diastereomers.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
authors.forename: Dennis X
authors.initials: DX
authors.lastname: Hu
authors.forename: Peter
authors.initials: P
authors.lastname: Grice
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley