title: Orbital aspergillosis: voriconazole - the new standard treatment?
abstract: OBJECTIVE
  To describe a case of invasive orbital aspergillosis and evaluate treatments and outcomes.
  
  
  METHODS
  A case report and review of orbital aspergillosis treatment with voriconazole in the English language literature.
  
  
  CONCLUSIONS
  Amphotericin B with debridement is the current standard of care for orbital aspergillosis; however, its prognosis is unfavorable. When compared to amphotericin B, voriconazole demonstrates a survival benefit, has less systemic toxicity, and is better tolerated by patients. While a prospective trial comparing amphotericin B to voriconazole in orbital aspergillosis is not feasible, there is evidence to support the use of voriconazole as primary therapy.
authors.affiliation: Neuro-Ophthalmology Service, Department of Ophthalmology, University of Florida, Gainesville, Fla., USA.
authors.forename: Derek H
authors.initials: DH
authors.lastname: Ohlstein
authors.forename: Claudia
authors.initials: C
authors.lastname: Hooten
authors.forename: Javier
authors.initials: J
authors.lastname: Perez
authors.forename: Charles L
authors.initials: CL
authors.lastname: Clark
authors.forename: Hazem
authors.initials: H
authors.lastname: Samy