title: In vivo bioavailability studies of sumatriptan succinate buccal tablets.
abstract: BACK GROUND AND THE PURPOSE OF STUDY:  Sumatriptan succinate is a Serotonin 5- HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability of about 15%. The aim of this work was to design mucoadhesive bilayered buccal tablets of sumatriptan succinate to improve its bioavailability.
  
  
  METHODS
  Mucoadhesive polymers carbopol 934 (Carbopol), HPMC K4M, HPMC K15M along with ethyl cellulose as an impermeable backing layer were used for the preparation of mucoadhesive bilayered tablets. In vivo bioavailability studies was also conducted in rabbits for optimized formulation using oral solution of sumatriptan succinate as standard.
  
  
  RESULTS
  Bilayered buccal tablets (BBT) containing the mixture of Carbopol and HPMC K4M in the ratio 1:1 (T1) had the maximum percentage of in vitro drug release within 6 hrs. The optimized formulation (T1) followed non-Fickian release mechanism. The percentage relative bioavailability of sumatriptan succinate from selected bilayered buccal tablets (T1) was found to be 140.78%.
  
  
  CONCLUSIONS
  Bilayered buccal tablets of sumatriptan succinate was successfully prepared with improved bioavailability.
authors.affiliation: Acharya and B M Reddy College of Pharmacy, Bangalore-560090, India.
authors.forename: K
authors.initials: K
authors.lastname: Shivanand
authors.forename: Sa
authors.initials: S
authors.lastname: Raju
authors.forename: S
authors.initials: S
authors.lastname: Nizamuddin
authors.forename: B
authors.initials: B
authors.lastname: Jayakar