title: DNA replication: Pif1 pulls the plug on stalled replication forks.
abstract: The conserved PIF helicase family appears to function in replication to ensure termination and passage through regions that slow or arrest replication fork movement. Findings in fission yeast extend evidence from budding yeast, and argue for universal mechanisms that ensure replication integrity.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. kenji.shimada@fmi.ch
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimada
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D004265:DNA Helicases / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D012568:Schizosaccharomyces / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000502:physiology*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C085463:PIF1 protein, S cerevisiae; D004265:DNA Helicases; C468287:Pfh1 protein, S pombe