title: Biomarkers of oxidative stress and personalized treatment of pulmonary tuberculosis: emerging role of gamma-glutamyltransferase.
abstract: Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 34.7 ± 5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% (n = 1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0-day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.
authors.affiliation: Faculty of Health Sciences, Anti-Tuberculosis Centre, National Laboratory of Public Health, Marien Ngouabi University, Brazzaville, Democratic Republic of Congo.
authors.forename: Etienne
authors.initials: E
authors.lastname: Mokondjimobe
authors.forename: Benjamin
authors.initials: B
authors.lastname: Longo-Mbenza
authors.forename: Jean
authors.initials: J
authors.lastname: Akiana
authors.forename: Ulrich Oswald
authors.initials: UO
authors.lastname: Ndalla
authors.forename: Regis
authors.initials: R
authors.lastname: Dossou-Yovo
authors.forename: Joseph
authors.initials: J
authors.lastname: Mboussa
authors.forename: Henri-Joseph
authors.initials: HJ
authors.lastname: Parra