title: Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization.
abstract: In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD). The average size of the mixed micelles was 68.2 nm, and the encapsulating efficiency for Cur was 86.93%, and 6.996% for drug-loading. Compared with the Cur propylene glycol solution, the in vitro release of Cur from Cur-PF presented the sustained-release property. The in vitro cytotoxicity assay showed that the IC(50) values on MCF-7 cells for Cur-PF and free Cur in DMSO solution were 5.04 μg/mL and 8.35 μg/mL, while 2.52 μg/mL and 8.27 μg/mL on MCF-7/ADR cells. It could be concluded from the results that P123/F68 mixed micelles might serve as a potential nanocarrier to improve the solubility and biological activity of Cur.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhao
authors.forename: Jianchao
authors.initials: J
authors.lastname: Du
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Duan
authors.forename: Ya'ni
authors.initials: Y
authors.lastname: Zang
authors.forename: Huaisong
authors.initials: H
authors.lastname: Zhang
authors.forename: Chunfen
authors.initials: C
authors.lastname: Yang
authors.forename: Fengliang
authors.initials: F
authors.lastname: Cao
authors.forename: Guangxi
authors.initials: G
authors.lastname: Zhai
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008823:Micelles; D011060:Poloxalene / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*
chemical_list: D008823:Micelles; D020442:Poloxamer; C464484:pluronic block copolymer P123; D011060:Poloxalene; D003474:Curcumin