title: Correlation between preoperative endometrial sampling and final endometrial cancer histology.
abstract: OBJECTIVE
  We conducted a study to evaluate the correlation between pre-operative endometrial sampling to the final endometrial cancer histology, in particular the non-endometrioid subtypes.
  
  
  METHODS
  This involved 191 hysterectomy specimens of patients undergoing treatment at the Pan-Birmingham Gynaecological Regional Cancer Centre (BGCC) over a two-year period (2006-2007).
  
  
  RESULTS
  The majority of the patients in this study were found to have endometrioid histology subtype (140/191, 73%). However, the non-endometrioid histologic subtypes were well presented in our population (51/191, 27%). We found good correlation for endometriod histology subtype (78%) and certain types of the non-endometrioid cell types (carcinosarcoma 90%, uterine papillary serous carcinoma 67%, clear cell carcinoma 67%) but poor in sarcomas (40%). Our results also demonstrated that both pre-operative endometrial sampling methods (curettage and pipelle biopsy) were reliable in identifying endometrioid and non-endometrioid cancer cell types, with sensitivities of 96.5% and 86.5%, respectively.
  
  
  CONCLUSIONS
  We concluded that preoperative endometrial sampling had good overall histological correlation to hysterectomised corpus specimen. This is especially so for the endometrioid and certain subtypes of the non-endometrioid endometrial cancer cells.
authors.affiliation: Pan-Birmingham Gynaecology Cancer Centre, Sandwell and West Birmingham NHS Trust, UK. omarsany@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Sany
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Jha
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D001706:Biopsy; D018269:Carcinoma, Endometrioid / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology*; D002296:Carcinosarcoma / Q000473:pathology; D004107:Dilatation and Curettage; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000473:pathology*