title: Distribution and effect of apo E genotype on plasma lipid and apolipoprotein profiles in overweight/obese and nonobese Chinese subjects.
abstract: BACKGROUND
  Apolipoprotein E (apo E) polymorphism has been reported to influence some lipid profile abnormalities in some ethnic groups. This study was conducted mainly to examine the possible association of apo E polymorphism with overweight/obesity in a South West Chinese population.
  
  
  METHODS
  Four hundred and fifty-four Han Chinese (282 overweight/obese and 172 normal weight control subjects) in Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
  
  
  RESULTS
  The genotype and allele frequencies of apo E polymorphism in cases of overweight/obesity showed no significant statistical difference compared to those of controls. In the control group, both apo E4 and E3 allele carriers had the higher serum LDL-C and lower triglycerides (TGs) and apo E concentrations than those with apo E2 carriers, while apo E2 allele carriers had higher serum apo C-II levels than apo E3 carriers (P < 0.05). In overweight/obese group, genotype-related low density Lipoprotein-Cholesterol (LDL-C) variations were also evident, with the changes being in a same direction as the effect in the controls, and apo B100 levels were decreased and apo E increased in apo E2 allele carriers when compared with respective apo E4 and apo E4/apo E3 allele carriers (all P < 0.05).
  
  
  CONCLUSIONS
  Polymorphism of the apo E gene is associated with altered plasma LDL-C and TG, as well as apo B, apo C-II, and apo E concentrations. The effects on TG, apo B, and apo C-II levels are BMI dependent in Chinese population of Chengdu area.
authors.affiliation: Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.lastname: Xuemei Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Fan
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Yin
authors.initials: Y
authors.lastname: Wu
authors.forename: Huai
authors.initials: H
authors.lastname: Bai
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001053:Apolipoproteins / Q000097:blood*; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D050177:Overweight / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D001057:Apolipoproteins E; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol