title: A pair of transmembrane receptors essential for the retention and pigmentation of hair.
abstract: Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits. When Bmpr2/Acvr2a function is reduced in cutaneous epithelium, hair follicles undergo rapid cycles of hair generation and loss. Alopecia results from a failure to terminate hair development properly, as hair clubs never form, and follicular retraction is slowed. Hair regeneration is rapid due to premature activation of new hair-production programs. Hair shafts differentiate aberrantly due to impaired arrest of medullary-cell proliferation. When Bmpr2/Acvr2a function is reduced in melanocytes, gray hair develops, as melanosomes differentiate but fail to grow, resulting in organelle miniaturization. We conclude that Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
authors.affiliation: Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Han
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Beppu
authors.forename: Yun-Kyoung
authors.initials: YK
authors.lastname: Lee
authors.forename: Katia
authors.initials: K
authors.lastname: Georgopoulos
authors.forename: Lionel
authors.initials: L
authors.lastname: Larue
authors.forename: En
authors.initials: E
authors.lastname: Li
authors.forename: Lorin
authors.initials: L
authors.lastname: Weiner
authors.forename: Janice L
authors.initials: JL
authors.lastname: Brissette
mesh_terms: D030301:Activin Receptors, Type II / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D000505:Alopecia / Q000235:genetics / Q000378:metabolism; D000818:Animals; D052006:Bone Morphogenetic Protein Receptors, Type II / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D005260:Female; D006197:Hair / Q000254:growth & development / Q000473:pathology / Q000503:physiopathology*; D006200:Hair Color; D018859:Hair Follicle / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000378:metabolism; D020460:Melanosomes / Q000378:metabolism / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D061251:Primary Cell Culture
chemical_list: D030301:Activin Receptors, Type II; C498219:Bmpr2 protein, mouse; D052006:Bone Morphogenetic Protein Receptors, Type II; C425585:activin receptor type II-A