title: Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss.
abstract: OBJECTIVE
  We carried out an in vivo study to assess the relationship between increase in adiposity in the marrow and osteocyte apoptosis in the case of alcohol-induced bone loss.
  
  
  RESULTS
  After alcohol treatment, the number of apoptotic osteocytes was increased and lipid droplets were accumulated within the osteocytes, the bone marrow and the cortical bone micro-vessels. At last, we found an inverse correlation between bone mineral density and osteocyte apoptosis and strong significant correlations between the osteocyte apoptotic number and lipid droplet accumulation in osteocyte and bone micro-vessels.
  
  
  CONCLUSIONS
  These data show that alcohol-induced bone loss is associated with osteocyte apoptosis and lipid accumulation in the bone tissue. This lipid intoxication, or 'bone steatosis', is correlated with lipid accumulation in bone marrow and blood micro-vessels.
authors.affiliation: IPROS Unité Inserm U658, Hôpital Porte Madeleine, 1 rue Porte Madeleine, BP 2439, Orléans cedex 01 45032, France.
authors.forename: Delphine B
authors.initials: DB
authors.lastname: Maurel
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pallu
authors.forename: Christelle
authors.initials: C
authors.lastname: Jaffré
authors.forename: Nicola L
authors.initials: NL
authors.lastname: Fazzalari
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boisseau
authors.forename: Rustem
authors.initials: R
authors.lastname: Uzbekov
authors.forename: Claude-Laurent
authors.initials: CL
authors.lastname: Benhamou
authors.forename: Gaël Y
authors.initials: GY
authors.lastname: Rochefort
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects*; D001851:Bone Diseases, Metabolic / Q000139:chemically induced* / Q000503:physiopathology; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000431:Ethanol / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis; D008297:Male; D046529:Microscopy, Electron, Transmission; D010011:Osteocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008055:Lipids; D000431:Ethanol