title: Plasticity and cross-talk of interleukin 6-type cytokines.
abstract: Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid overshooting activities. Here, molecular mechanisms of inter-familiar cytokine cross-talk are reviewed which regulate dynamics and strength of IL-6 signal transduction. Both plasticity and cytokine cross-talk are significantly involved in pro- and anti-inflammatory/regenerative properties of IL-6-type cytokines. Furthermore, we focus on IL-6-type cytokine/cytokine receptor plasticity and cross-talk exemplified by the recently identified composite cytokines IL-30/IL-6R and IL-35, the first inter-familiar IL-6/IL-12 family member. The complete understanding of the intra- and extracellular cytokine networks will aid to develop novel tailor-made therapeutic strategies with reduced side effects.
authors.affiliation: Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Garbers
authors.forename: Heike M
authors.initials: HM
authors.lastname: Hermanns
authors.forename: Fred
authors.initials: F
authors.lastname: Schaper
authors.forename: Gerhard
authors.initials: G
authors.lastname: Müller-Newen
authors.forename: Joachim
authors.initials: J
authors.lastname: Grötzinger
authors.forename: Stefan
authors.initials: S
authors.lastname: Rose-John
authors.forename: Jürgen
authors.initials: J
authors.lastname: Scheller
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D050822:Cytokine Receptor gp130 / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D018664:Interleukin-12 / Q000276:immunology; D015850:Interleukin-6 / Q000502:physiology*; D007378:Interleukins / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D018121:Receptors, Cytokine / Q000276:immunology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D019947:Receptors, Interleukin-6 / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005938:Glucocorticoids; C494199:IL6ST protein, human; D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D018121:Receptors, Cytokine; D043562:Receptors, G-Protein-Coupled; D019947:Receptors, Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C532417:interleukin-35, human; D050822:Cytokine Receptor gp130; D018664:Interleukin-12; D020794:Receptor Protein-Tyrosine Kinases