title: Type 1 immune response in progressive multiple sclerosis.
abstract: The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4+T-bet+ or CD8+T-bet+ T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
authors.affiliation: Department of Neurology, Catholic University of Sacred Heart Rome, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Frisullo
authors.forename: Domenico
authors.initials: D
authors.lastname: Plantone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marti
authors.forename: Raffaele
authors.initials: R
authors.lastname: Iorio
authors.forename: Valentina
authors.initials: V
authors.lastname: Damato
authors.forename: Viviana
authors.initials: V
authors.lastname: Nociti
authors.forename: Agata Katia
authors.initials: AK
authors.lastname: Patanella
authors.forename: Assunta
authors.initials: A
authors.lastname: Bianco
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Batocchi
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology*; D012720:Severity of Illness Index; D020825:T-Box Domain Proteins / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor