title: Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse.
abstract: OBJECTIVE
  To investigate the recurrent risk factors of intracranial meningiomas after gross-total resection (Simpson II Grade).
  
  
  METHODS
  We retrospectively analysed 162 meningiomas in the General Hospital of Shenyang Military Region and Changzheng Hospital in Shanghai China, which underwent nearly gross-total resection using microneurosurgery techniques from 2002 to 2007. Monofactorial and Cox regression statistics methods were carried out to analyse the relationship between the post-operation tumour relapse and some clinical features including the patient sex, age, tumour size, tumour shape, tumour pathological grade and the immunohistochemical expression levels of Ki-67, androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR).
  
  
  RESULTS
  There are 53 recurrent meningiomas during the follow-up period. The recurrent rate is about 32.7%. Immunohistochemistry results indicate that AR, ER, PR, Ki-67 are positively expressed on some tumour cell nuclear. Cox regression analysis reveals that tumour size, tumour shape, pathological grade and Ki-67 expression levels are significantly correlated with the tumour relapse (p <0.05).
  
  
  CONCLUSIONS
  Our results demonstrate high recurrent rate for gross-total resection meningiomas. Tumour diameter exceeding 5 cm, irregular shape tumour, pathological grade II and III and positive expression of Ki-67 were the risk factors for post-operation meningioma relapse. The recurrent rate increases coincidentally with the follow-up period.
authors.affiliation: Department of Neurosurgery, Northern Hospital, No 83, Wenhua Road, Shenhe District, Shenyang, Liaoning Province, China.
authors.forename: Yingqun
authors.initials: Y
authors.lastname: Tao
authors.forename: Guobiao
authors.initials: G
authors.lastname: Liang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Wang
authors.forename: Anhua
authors.initials: A
authors.lastname: Wu
authors.forename: Hailong
authors.initials: H
authors.lastname: Wang
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Lu
authors.forename: Zhenyang
authors.initials: Z
authors.lastname: Liu
authors.forename: Guohan
authors.initials: G
authors.lastname: Hu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000601:surgery; D008579:Meningioma / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid