title: Differentially degradable janus particles for controlled release applications.
abstract: Janus particles with differentially degradable compartments were prepared by electrohydrodynamic (EHD) co-jetting and subsequent controlled crosslinking. These bicompartmental particles are composed of an interpenetrating polymer network of poly(ethylene oxide) and poly(acrylamide-co-acrylic acid) in one hemisphere and a crosslinked copolymer of dextran and poly(acrylamide-co-acrylic acid) segments in the second compartment. The compositional anisotropy caused differential hydrolytic susceptibility: Although both compartments were stable at pH 3.0, selective degradation of the PEO-containing compartment pH 7.4 was observed within 5 days. Janus particles with differentially degradable polymer compartments may be of interest for a range of oral drug delivery applications because of their propensity for decoupled release profiles.
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, 48109, USA.
authors.forename: Sangyeul
authors.initials: S
authors.lastname: Hwang
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008863:Microspheres; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D003911:Dextrans; D011108:Polymers; D011092:Polyethylene Glycols