title: Thiamin biosynthesis: still yielding fascinating biological chemistry.
abstract: The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77843, U.S.A. Begley@chem.tamu.edu
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
authors.forename: Steven E
authors.initials: SE
authors.lastname: Ealick
authors.forename: Fred W
authors.initials: FW
authors.lastname: McLafferty
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism*; D053898:Biosynthetic Pathways; D007535:Isomerases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013440:Sulfides / Q000378:metabolism; D013831:Thiamine / Q000096:biosynthesis* / Q000737:chemistry
chemical_list: D013440:Sulfides; D007535:Isomerases; D013831:Thiamine