title: Cerebral hypoperfusion during carotid artery stenosis can lead to cognitive deficits that may be independent of white matter lesion load.
abstract: Studies investigating cognitive impairment in stroke-free patients with carotid artery stenosis have led to inconsistent results. Furthermore, the pathophysiological mechanism leading to cognitive impairment remains unclear. Cerebral hypoperfusion and arterio-arterial microembolization are discussed. The aims of our study were (1) to delineate patterns of cognitive impairment in stroke-free patients with carotid artery stenosis and (2) to investigate if cognitive impairment is independent of white matter lesion load in brain MRI. We identified 212 (93 women, mean age 70.2) stroke free, non-demented patients, who were referred for carotid artery stenting or because of subjective cognitive impairment. All patients completed a neurocognitive test battery measuring verbal fluency, constructional praxis, figural memory, verbal short-term- and long-term-memory, verbal recognition memory, semantic processing, speed of cognitive processing and divided attention. Grade of maximum carotid artery stenosis was categorized into three groups (mild, moderate, or severe). White matter lesion load was graded using a visual rating scale. Cognitive test scores of groups with different grades of carotid artery stenosis were compared. Univariate regression analysis was used to measure the predictive value of carotid artery stenosis. Multivariate logistic regression analysis was performed when integrating carotid artery stenosis and white matter lesion load. Carotid artery stenosis negatively correlated with measures of verbal fluency, constructional praxis, verbal short-term-memory, semantic processing, speed of cognitive processing, and divided attention. After adjustment for white matter lesions, carotid artery stenosis did not independently predict divided attention. Significance persisted in all other cognitive domains. In our selected group of patients, a higher grade of carotid artery stenosis is associated with cognitive decline. This process is independent of white matter lesion load. Possible pathophysiological implications are discussed.
authors.affiliation: Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University Salzburg, Austria. m.scherr@salk.at
authors.forename: Martin
authors.initials: M
authors.lastname: Scherr
authors.forename: Eugen
authors.initials: E
authors.lastname: Trinka
authors.forename: Mark
authors.initials: M
authors.lastname: Mc Coy
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Krenn
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Staffen
authors.forename: Margarita
authors.initials: M
authors.lastname: Kirschner
authors.forename: Hans Jürgen
authors.initials: HJ
authors.lastname: Bergmann
authors.forename: Johannes Sebastian
authors.initials: JS
authors.lastname: Mutzenbach
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D016893:Carotid Stenosis / Q000150:complications / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D018608:Ultrasonography, Doppler