title: Synthesis and characterization of multifunctional Fe3O4/poly(fluorescein O-methacrylate) core/shell nanoparticles.
abstract: Multifunctional fluorescent and superparamagnetic Fe(3)O(4)/poly(fluorescein O-methacrylate) [Fe(3)O(4)/poly(FMA)] nanoparticles with core/shell structure were synthesized via surface-initiated polymerization. First, polymerizable double bonds were introduced onto the surface of Fe(3)O(4) nanoparticles via ligand exchange and a condensation reaction. A fluorescent monomer, FMA, was then polymerized to the double bonds at the surface via free-radical polymerization, leading to form a fluorescent polymer shell around the superparamagnetic Fe(3)O(4) core. The resultant Fe(3)O(4)/poly(FMA) nanoparticles were characterized by Fourier transform infrared, nuclear magnetic resonance, and X-ray diffraction spectroscopy to confirm the reactions. Transmission electron microscopy images showed that the Fe(3)O(4)/poly(FMA) nanoparticles have a spherical and monodisperse core/shell morphology. Photoluminescence spectroscopy and superconducting quantum interference device magnetometer analyses confirmed that the Fe(3)O(4)/poly(FMA) nanoparticles exhibited fluorescent and superparamagnetic properties, respectively. In addition, we demonstrated the potential bioimaging application of the Fe(3)O(4)/poly(FMA) nanoparticles by visualizing the cellular uptake of the nanoparticles into A549 lung cancer cells.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea.
authors.forename: Patakamuri
authors.initials: P
authors.lastname: Govindaiah
authors.forename: Taewon
authors.initials: T
authors.lastname: Hwang
authors.forename: Hyunhee
authors.initials: H
authors.lastname: Yoo
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Kim
authors.forename: Sun Jong
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Choi
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D045744:Cell Line, Tumor; D005452:Fluoresceins / Q000737:chemistry*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D058105:Polymerization; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D005452:Fluoresceins; D058185:Magnetite Nanoparticles; C575614:poly(fluorescein O-methylacrylate)