title: In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection.
abstract: While most carriers of human T-cell leukemia virus type 1 (HTLV-1) remain asymptomatic throughout their lifetime, infection is associated with the development of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact parameters that determine these outcomes are unknown but are believed to include host genetic factors that control the immune response to infection. Host response to fellow retroviridae member HIV is influenced by the expression of members of the Killer Immunoglobulin Receptor (KIR) family including KIR3DS1. In this study we examined the association of KIR3DS1 with the outcome of HTLV-1 infection in three geographically distinct cohorts (Jamaican, Japanese and Brazilian). Despite increased prevalence of KIR3DS1 in the HAM/TSP patients of the Jamaican cohort, we found no evidence for a role of KIR3DS1 in influencing control of proviral load or disease outcome. This suggests that unlike HIV, KIR3DS1-mediated regulation of HTLV-1 infection does not occur, or is ineffective.
authors.affiliation: Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick, Frederick, MD 21702, USA. oconnorg@mail.nih.gov
authors.forename: Geraldine M
authors.initials: GM
authors.lastname: O'Connor
authors.forename: Nafisa-Katrin
authors.initials: NK
authors.lastname: Seich Al Basatena
authors.forename: Viviana
authors.initials: V
authors.lastname: Olavarria
authors.forename: Aidan
authors.initials: A
authors.lastname: MacNamara
authors.forename: Alison
authors.initials: A
authors.lastname: Vine
authors.forename: Qi
authors.initials: Q
authors.lastname: Ying
authors.forename: Michie
authors.initials: M
authors.lastname: Hisada
authors.forename: Bernardo
authors.initials: B
authors.lastname: Galvão-Castro
authors.forename: Becca
authors.initials: B
authors.lastname: Asquith
authors.forename: Daniel W
authors.initials: DW
authors.lastname: McVicar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D007563:Jamaica / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000208:ethnology / Q000276:immunology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000208:ethnology / Q000276:immunology* / Q000821:virology; D015995:Prevalence; D011379:Prognosis; D054349:Receptors, KIR3DS1 / Q000235:genetics / Q000276:immunology*; D013118:Spinal Cord Diseases / Q000150:complications / Q000208:ethnology / Q000276:immunology* / Q000821:virology; D019562:Viral Load
chemical_list: D054349:Receptors, KIR3DS1