title: Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators.
abstract: We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal chemistry.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Chen
authors.initials: C
authors.lastname: Fu
authors.forename: Tom
authors.initials: T
authors.lastname: Breiding
authors.forename: Pijus K
authors.initials: PK
authors.lastname: Sasmal
authors.forename: Haidong
authors.initials: H
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.forename: Lilu
authors.initials: L
authors.lastname: Zhang
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D017646:Organosilicon Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D007364:Intercalating Agents; D017646:Organosilicon Compounds; D004247:DNA