title: Continuous-flow synthesis of activated vitamin D3 and its analogues.
abstract: An efficient, two-stage, continuous-flow synthesis of 1α,25-(OH)(2)-vitamin D(3) (activated vitamin D(3)) and its analogues was achieved. The developed method afforded the desired products in satisfactory yields using a high-intensity and economical light source, i.e., a high-pressure mercury lamp. In addition, our method required neither intermediate purification nor high-dilution conditions.
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Tokyo 152-8552, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Fuse
authors.forename: Yuto
authors.initials: Y
authors.lastname: Mifune
authors.forename: Nobutake
authors.initials: N
authors.lastname: Tanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D002762:Cholecalciferol