title: Iridocorneal angle measurements in mammalian species: normative data by optical coherence tomography.
abstract: Objective  Gonioscopy provides limited quantitative information to compare the iridocorneal anatomy across different species. In addition, the anatomic relationships by histologic examination are altered during processing. As a result, the comparative anatomy of the iridocorneal angle across several mammalian species was evaluated by Optical Coherence Tomography (OCT). Methods  Cats, beagle dogs, minipigs, owl monkeys, cynomolgus monkeys, and rhesus monkeys (n = 6 or 7 per species) were evaluated. Imaging was performed using the OCT. The anterior chamber angle (ACA), angle opening distance (AOD), and the angle recess area (ARA) were evaluated. Results  AC angle: cat (63 ± 6°) > owl monkey (54 ± 4°) > beagle dog (42 ± 4°) > minipig (40 ± 3°) > rhesus monkey (36 ± 1°) > cynomolgus monkey (34 ± 2°). AOD: cat (3.3 ± 0.5 mm) > owl monkey (2.05 ± 0.2 mm) > beagle dog (1.08 ± 0.1 mm) > rhesus monkey (0.92 ± 0.06 mm) > minipig (0.64 ± 0.04 mm) > cynomolgus monkey (0.43 ± 0.03 mm). ARA: cat (3.5 ± 0.1 mm(2) ) > owl monkey (1.41 ± 0.2 mm(2) ) > dog (0.88 ± 0.1 mm(2) ) > rhesus monkey (0.62 ± 0.06 mm(2) ) > minipig (0.21 ± 0.05 mm(2) ) > cynomolgus monkey (0.15 ± 0.01 mm(2) ). Conclusions  This study benchmarks the normative iridocorneal angle measurements across different mammalian species by OCT. These data can be useful to compare iridocorneal angle measurements in disease states as OCT evolves as a common diagnostic tool in veterinary ophthalmic research and practice.
authors.affiliation: Allergan, Inc. Irvine, CA, USA. almazan_alexandra@allergan.com
authors.forename: Alexandra
authors.initials: A
authors.lastname: Almazan
authors.forename: Susan
authors.initials: S
authors.lastname: Tsai
authors.forename: Paul E
authors.initials: PE
authors.lastname: Miller
authors.forename: Susan S
authors.initials: SS
authors.lastname: Lee
authors.forename: Abhiram S
authors.initials: AS
authors.lastname: Vilupuru
authors.forename: James A
authors.initials: JA
authors.lastname: Burke
authors.forename: Michael R
authors.initials: MR
authors.lastname: Robinson
mesh_terms: D000818:Animals; D005123:Eye / Q000033:anatomy & histology*; D008322:Mammals / Q000033:anatomy & histology*; D013045:Species Specificity; D041623:Tomography, Optical Coherence / Q000662:veterinary*