title: Nebivolol therapy improves QTc and QTcd parameters in heart failure patients.
abstract: OBJECTIVE
  It has previously been shown that β-blocker therapy reduces QT dynamics in heart failure patients. The aim of this study was to demonstrate this improvement with the third-generation β-blocker, nebivolol.
  
  
  METHODS
  A total of 72 heart failure patients with systolic dysfunction were included in the study. Corrected QT (QTc) and QT dispersion (QTcd) were measured manually by two independent observers at baseline and after nebivolol use (5 mg/day) in the first and third months of follow up.
  
  
  RESULTS
  Both QTc and QTcd were found to be significantly reduced in the first (455.3 ± 26.7 vs 441.2 ± 25.7 ms, p < 0.001 for QTc, and 65.6 ± 5.3 vs 58.2 ± 5.6 ms, p = 0.001 for QTcd) and third months (455.3 ± 26.7 vs 436.0 ± 28.7 ms, p < 0.001 for QTc, and 65.6 ± 5.3 vs 56.0 ± 6.2 ms, p < 0.001 for QTcd) compared with baseline values.
  
  
  CONCLUSIONS
  Nebivolol was associated with improved QT dynamics in heart failure patients with systolic dysfunction.
authors.affiliation: Department of Anesthesiology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
authors.forename: S M
authors.initials: SM
authors.lastname: Aksoy
authors.forename: S
authors.initials: S
authors.lastname: Cay
authors.forename: G
authors.initials: G
authors.lastname: Cagirci
authors.forename: N
authors.initials: N
authors.lastname: Sen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D001578:Benzopyrans / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects*; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D000068577:Nebivolol; D010975:Platelet Aggregation Inhibitors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D010975:Platelet Aggregation Inhibitors; D000068577:Nebivolol