title: Unique mitochondrial DNA in highly inbred feral cattle.
abstract: The Chillingham herd of wild Northumbrian cattle remains viable despite over 300 years of in-breeding and a near-homozygous nuclear genome. Here we report the complete mitochondrial DNA sequence using ultra-deep next generation sequencing. Random population sampling of ~10% of the extant herd identified a single mtDNA haplotype harbouring a unique bovine variant present in all other higher mammals (m.11789C/Y421H) which may contribute to their survival.
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Gavin
authors.initials: G
authors.lastname: Hudson
authors.forename: Ian
authors.initials: I
authors.lastname: Wilson
authors.forename: Brendan I A
authors.initials: BI
authors.lastname: Payne
authors.forename: Joanna
authors.initials: J
authors.lastname: Elson
authors.forename: David C
authors.initials: DC
authors.lastname: Samuels
authors.forename: Mauro
authors.initials: M
authors.lastname: Santibanez-Korev
authors.forename: Stephen J G
authors.initials: SJ
authors.lastname: Hall
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains / Q000235:genetics*; D002417:Cattle; D016000:Cluster Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D054629:Genome, Mitochondrial; D006239:Haplotypes; D059014:High-Throughput Nucleotide Sequencing; D010802:Phylogeny
chemical_list: D004272:DNA, Mitochondrial