title: Norditerpenoids from Salvia castanea Diels f. pubescens.
abstract: Three new norditerpenoids, castanol A-C (1-3), along with eighteen known diterpenoids, were isolated from Salvia castanea Diels f. pubescens. Their structures were elucidated by extensive spectroscopic analysis. All compounds were evaluated for their cytotoxic activities against five human cancer cell lines. The known compounds neo-tanshinlactone (12) and methyltanshinoate (17) exhibited significant cytotoxic activities against some cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D027544:Salvia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005663:Furans; D010936:Plant Extracts; D011753:Pyrones; C576433:castanol A; C576434:castanol B; C576435:castanol C; C576461:methyltanshinoate; C494351:neotanshinlactone