title: Acetylcholinesterase inhibitory activity of Thai traditional nootropic remedy and its herbal ingredients.
abstract: The incidence of Alzheimer disease (AD) is increasing every year in accordance with the increasing of elderly population and could pose significant health problems in the future. The use of medicinal plants as an alternative prevention or even for a possible treatment of the AD is, therefore, becoming an interesting research issue. Acetylcholinesterase (AChE) inhibitors are well-known drugs commonly used in the treatment of AD. The aim of the present study was to screen for AChE inhibitory activity of the Thai traditional nootropic recipe and its herbal ingredients. The results showed that ethanolic extracts of four out of twenty-five herbs i.e. Stephania pierrei Diels. Kaempfera parviflora Wall. ex Baker, Stephania venosa (Blume) Spreng, Piper nigrum L at 0.1 mg/mL showed % AChE inhibition of 89, 64, 59, 50; the IC50 were 6, 21, 29, 30 microg/mL respectively. The other herbs as well as combination of the whole recipe had no synergistic inhibitory effect on AChE activity. However some plants revealed antioxidant activity. More research should have be performed on this local wisdom remedy to verify the uses in scientific term.
authors.affiliation: Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumtani, Thailand. pimolvan6776@yahoo.com
authors.forename: Pimolvan
authors.initials: P
authors.lastname: Tappayuthpijarn
authors.forename: Arunporn
authors.initials: A
authors.lastname: Itharat
authors.forename: Sunita
authors.initials: S
authors.lastname: Makchuchit
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003704:Dementia / Q000188:drug therapy; D006801:Humans; D008519:Medicine, Traditional; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D013785:Thailand
chemical_list: D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D010936:Plant Extracts