title: Lambert-Eaton myasthenic syndrome and solitary cerebellar metastasis in a patient with occult small-cell lung cancer: a rare experience.
abstract: The authors describe a case of 60-year-old male patient presented with a 6 month history of progressive weakness of all the four limbs, ataxia, droopy eyelids and bulbar features. Further laboratory and electrodiagnostic studies confirmed the diagnosis of Lambert-Eaton myasthenic syndrome (LEMS). MRI of the brain showed a cerebellar tumour which, following surgery was revealed to be a metastatic small-cell lung carcinoma. Paraneoplastic LEMS together with solitary cerebellar metastasis was diagnosed but no evidence of primary malignancy was detected. An extensive search for related malignancies failed to get any clue. The patient underwent a total surgical excision of tumour and the histopathology revealed a metastatic small cell carcinoma. This case highlights that rarely both paraneoplastic LEMS and cerebellar mass can precede the primary malignancy causing them.
authors.affiliation: Department of General Medicine, Medical College Kolkata, Kolkata, West Bengal, India.
authors.forename: Sayantan
authors.initials: S
authors.lastname: Ray
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sonthalia
authors.forename: Supratip
authors.initials: S
authors.lastname: Kundu
authors.forename: Subhasis
authors.initials: S
authors.lastname: Maitra
authors.forename: Manjari
authors.initials: M
authors.lastname: Saha
authors.forename: Arunansu
authors.initials: A
authors.lastname: Talukdar
mesh_terms: D018288:Carcinoma, Small Cell / Q000556:secondary* / Q000601:surgery; D002528:Cerebellar Neoplasms / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged