title: Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms.
abstract: The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse-event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology-based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework.
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Zhichkin
authors.forename: B D
authors.initials: BD
authors.lastname: Athey
authors.forename: M I
authors.initials: MI
authors.lastname: Avigan
authors.forename: D R
authors.initials: DR
authors.lastname: Abernethy
mesh_terms: D001499:Bayes Theorem; D002965:Classification; D002986:Clinical Trials as Topic; D019295:Computational Biology; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions / Q000145:classification*; D006801:Humans; D017146:Models, Organizational; D060735:Pharmacovigilance; D011634:Public Health; D009626:Terminology as Topic