title: Efficacy of systematic pelvic lymphadenectomy in patients with non-endometrioid endometrial cancers: a retrospective, multicenter study in Korea.
abstract: OBJECTIVE
  Non-endometrioid endometrial cancer is a clinically and pathologically distinct subtype of endometrial cancer. The aim of this study was to determine whether systematic pelvic lymphadenectomy improves overall survival compared to no lymphadenectomy in non-endometrioid endometrial cancer.
  
  
  METHODS
  The authors retrospectively reviewed the medical records and pathological findings of 112 patients who underwent surgical staging for non-endometrioid endometrial cancer from 2000 to 2006 in Korea.
  
  
  RESULTS
  Systematic pelvic lymphadenectomy was performed in 71 patients. Pelvic lymph node metastases were identified in 31% and 14.6% patients who underwent systematic pelvic lymphadenectomy and no lymphadenectomy, respectively. After adjusting for risk factors, there was no significant difference in overall survival (odds ratio = 0.69; 95% confidence interval, 0.29-1.67) between patients who did or did not undergo systematic pelvic lymphadenectomy. On multivariate analysis, patients with lymph node metastasis had higher risk of death (odds ratio = 3.11; 95% confidence interval, 0.97-10.00) than the patients with no lymph node metastasis.
  
  
  CONCLUSIONS
  Although systematic pelvic lymphadenectomy did not affect overall survival in patients with the non-endometrioid subtype, it has the potential benefit of providing prognostic information and acting as a guide for further adjuvant treatment.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Korea.
authors.forename: Seo-Yun
authors.initials: SY
authors.lastname: Tong
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Choi
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Chi-Heum
authors.initials: CH
authors.lastname: Cho
authors.forename: Seok-Mo
authors.initials: SM
authors.lastname: Kim
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
authors.forename: Chan-Yong
authors.initials: CY
authors.lastname: Park
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010052:Ovariectomy; D010388:Pelvis; D056910:Republic of Korea; D012189:Retrospective Studies; D058994:Salpingectomy; D016019:Survival Analysis; D016896:Treatment Outcome