title: Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging.
abstract: Carotid angioplasty and stenting is a minimally invasive endovascular procedure that may benefit from in vivo high resolution imaging for monitoring the physical placement of the stent and potential complications. The purpose of this pilot study was to evaluate the ability of optical coherence tomography to construct high resolution 2D and 3D images of stenting in porcine carotid artery. Four Yorkshire pigs were anaesthetized and catheterized. A state-of-the-art optical coherence tomography (OCT) system and an automated injector were used to obtain both healthy and stented porcine carotid artery images. Data obtained were then processed for visualization. The state-of-the-art OCT system was able to capture high resolution images of both healthy and stented carotid arteries. High quality 3D images of healthy and stented carotid arteries were constructed, clearly depicting vessel wall morphological features, stent apposition and thrombus formation over the inserted stent. The results demonstrate that OCT can be used to generate high quality 3D images of carotid arterial stents for accurate diagnosis of stent apposition and complications under appropriate imaging conditions.
authors.affiliation: Biophotonics and Bioengineering Laboratory, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada.
authors.forename: Kyle H Y
authors.initials: KH
authors.lastname: Cheng
authors.forename: Cuiru
authors.initials: C
authors.lastname: Sun
authors.forename: Juan P
authors.initials: JP
authors.lastname: Cruz
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Marotta
authors.forename: Julian
authors.initials: J
authors.lastname: Spears
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Montanera
authors.forename: Aman
authors.initials: A
authors.lastname: Thind
authors.forename: Brian
authors.initials: B
authors.lastname: Courtney
authors.forename: Beau A
authors.initials: BA
authors.lastname: Standish
authors.forename: Victor X D
authors.initials: VX
authors.lastname: Yang
mesh_terms: D000465:Algorithms; D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000601:surgery*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015607:Stents; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013552:Swine; D041623:Tomography, Optical Coherence / Q000379:methods*