title: Tailored poly(2-oxazoline) polymer brushes to control protein adsorption and cell adhesion.
abstract: POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.
authors.affiliation: Wacker-Lehrstuhl für Makromolekulare Chemie, Chemie-Department, TU München, Garching, Germany.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Tilo
authors.initials: T
authors.lastname: Pompe
authors.forename: Ihsan
authors.initials: I
authors.lastname: Amin
authors.forename: Robert
authors.initials: R
authors.lastname: Luxenhofer
authors.forename: Carsten
authors.initials: C
authors.lastname: Werner
authors.forename: Rainer
authors.initials: R
authors.lastname: Jordan
mesh_terms: D000327:Adsorption / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D005353:Fibronectins / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D018625:Microscopy, Atomic Force; D011073:Polyamines / Q000737:chemistry*; D011437:Propylamines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D005353:Fibronectins; D011073:Polyamines; D011437:Propylamines; D012821:Silanes; C511916:poly(2-ethyl-2-oxazoline); C117403:poly(2-methyl-2-oxazoline); C088294:3-aminopropyltrimethoxysilane; D012825:Silicon