title: [Modification of the nitric oxide concentration regulates the development of the apoptosis in the eye retina].
abstract: Using model elaborated it was shown that the retinal ischemia initiated the development of the apoptosis in the inner layers of the retina. Administration of NOS inhibitor prevented the development of the apoptosis in the retina. To ascertain if nitric oxide could induce the retinal apoptosis by itself the nontoxic donor of nitric oxide (dinitrosyl iron complex) was injected intravitreally. Administration of DNIC in low concentrations induced the development of the apoptosis in the same retinal layers as in ischemia. The injection of dinitrosyl iron complex at the higher concentration resulted in the decrease of the apoptosis level. Administration of dinitrosyl iron complex with excess of glutathione didn't lead to the development of the retinal apoptosis. The obtained data demonstrates the neurotoxic properties of the excess of nitric oxide in the retina.
authors.forename: T S
authors.initials: TS
authors.lastname: Konstantinova
authors.forename: A E
authors.initials: AE
authors.lastname: Bugrova
authors.forename: T F
authors.initials: TF
authors.lastname: Shevchenko
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
authors.forename: G R
authors.initials: GR
authors.lastname: Kalamkarov
mesh_terms: D000818:Animals; D017209:Apoptosis; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology; D007511:Ischemia / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D009589:Nitrogen Oxides / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D012171:Retinal Vessels / Q000378:metabolism / Q000473:pathology
chemical_list: D004791:Enzyme Inhibitors; D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione