title: Biological activity of novel N-substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid and N-substituted amides of 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acids.
abstract: N-Substituted amides of endo-3-(3-methylthio-1,2,4-triazol-5-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid and 1-(5-methylthio-1,2,4-triazol-3-yl)cyclohexane-2-carboxylic acid were prepared by the condensation reaction of endo-S-methyl-N1-(bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl)isothiosemicarbazide and S-methyl-N1-(cyclohexane-2,3-dicarbonyl)isothiosemicarbazide with primary amines. The synthesized compounds were screened for their microbiological and pharmacological activities.
authors.affiliation: Department of Organic Chemistry, Medical University, Chodźki 4a, 20-093 Lublin, Poland. anna.pachuta@am.lublin.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Pachuta-Stec
authors.forename: Urszula
authors.initials: U
authors.lastname: Kosikowska
authors.forename: Anna
authors.initials: A
authors.lastname: Chodkowska
authors.forename: Monika
authors.initials: M
authors.lastname: Pitucha
authors.forename: Anna
authors.initials: A
authors.lastname: Malm
authors.forename: Ewa
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
mesh_terms: D000577:Amides / Q000737:chemistry*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000577:Amides; D000700:Analgesics; D000890:Anti-Infective Agents; D002264:Carboxylic Acids