title: A ligand-free Pd-catalyzed cascade reaction: an access to the highly diverse isoquinolin-1(2H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursors.
abstract: A novel ligand-free palladium-catalyzed cascade reaction for the synthesis of highly diverse isoquinolin-1(2H)-one derivatives from isocyanide and amide precursors synthesized by Ugi-MCR has been developed. A broad variety of acids, amines, and isocyanides were used as starting materials for Ugi-MCR leading to various amide precursors, which in turn provided entry into diverse isoquinolin-1(2H)-one derivatives. The reaction proceeds through tandem isocyanide insertion with intramolecular cyclization followed by a Mazurciewitcz-Ganesan type sequence to provide isoquinoline-1(2H)-one derivatives in moderate to good yields.
authors.affiliation: Medicinal and Process Chemistry Division, Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow, 226 001, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Tyagi
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Khan
authors.forename: Archana
authors.initials: A
authors.lastname: Giri
authors.forename: Harsh M
authors.initials: HM
authors.lastname: Gauniyal
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D007546:Isoquinolines / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D003486:Cyanides; D007546:Isoquinolines; D008024:Ligands; D010165:Palladium; C039109:isoquinoline