title: Cytotoxicity of semisynthetic acetal triterpenes from one-pot vicinal diol cleavage following by lactolization: reaction promoted by NaIO4/SiO2 gel in THF.
abstract: In situ C-C bond cleavage of vicinal diol following by the lactolisation resulted from separated treatment of Arjunolic acid (1), 24-hydroxytormentic acid (2) and 3-O-β-D-glucopyranosylsitosterol (3) with sodium periodate and silica gel in dried THF according to the strategic position of hydroxyl functions in the molecule. The reaction led to a lactol pentacyclic triterpenes 1A, 2A and a bicyclotriacetal of β-sitosterol 3A. These products were further acetylated and the cytotoxicity of all molecules was evaluated against human fibrosarcoma HT1080 cancer cells lines.
authors.affiliation: Department of Organic Chemistry Faculty of Sciences , P.O. Box 812 University of Yaoundé 1, Yaoundé, Cameroon. plsandjo@yahoo.fr
authors.forename: Louis Pergaud
authors.initials: LP
authors.lastname: Sandjo
authors.forename: Aurelie Vigee Barry Songfack
authors.initials: AV
authors.lastname: Djoumessi
authors.forename: Vincent
authors.initials: V
authors.lastname: Rincheval
authors.forename: Hervé Martial Poumale
authors.initials: HM
authors.lastname: Poumale
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010504:Periodic Acid / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D014315:Triterpenes; D010504:Periodic Acid; C061640:arjunolic acid; D012822:Silicon Dioxide; C009288:metaperiodate