title: Three new azaphilones produced by a marine fish-derived chaetomium globosum.
abstract: Three new metabolites, chaetomugilin S, dechloro-chaetomugilin A and dechloro-chaetomugilin D, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and some chemical transformations. Particularly, chaetomugilins T and U are the first compounds without a chlorine atom in azaphilones isolated from this fungal strain, to date. In addition, these compounds moderately inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Laboratory of Medical Chemistry, Nasahara, Takatsuki, Japan. yamada@gly.oups.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Masaaki
authors.initials: M
authors.lastname: Jinno
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Numata
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry*; D005399:Fishes / Q000382:microbiology*; D018922:HL-60 Cells; D006801:Humans; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans