title: Protein-losing enteropathy and premature ovarian failure in a young woman with systemic lupus erythematosus.
abstract: Protein-losing enteropathy (PLE) and autoimmune oophoritis are unusual manifestations of systemic lupus erythematosus (SLE). Autoimmune oophoritis may result in menstrual disturbance and spontaneous premature ovarian failure. However, there is no validated examination to confirm the diagnosis and it is easily neglected in patients with ovarian insufficiency. A 31-year-old woman with SLE presented with PLE and autoimmune oophoritis during the long course of flares and remissions in her lupus activity. The synchronism implied the association between the two. Moreover, both conditions simultaneously had a good response to cyclosporine A (CsA) therapy.
authors.affiliation: Division of Allergy, Immunology and Rheumatology and, Department of Medicine, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan.
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
authors.forename: C C
authors.initials: CC
authors.lastname: Lai
authors.forename: W S
authors.initials: WS
authors.lastname: Chen
authors.forename: S H
authors.initials: SH
authors.lastname: Wang
authors.forename: C T
authors.initials: CT
authors.lastname: Chou
authors.forename: C Y
authors.initials: CY
authors.lastname: Tsai
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D009869:Oophoritis / Q000175:diagnosis / Q000209:etiology*; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy / Q000209:etiology; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine