title: MicroRNA regulation of lipid metabolism.
abstract: MicroRNAs are structural components of an epigenetic mechanism of post-transcriptional regulation of messenger RNA translation. Recently, there is significant interest in the application of microRNA as a blood-based biomarker of underlying physiologic conditions, and the therapeutic administration of microRNA inhibitors and mimics. The purpose of this review is to describe the current body of knowledge on microRNA regulation of genes involved in lipid metabolism, and to introduce the role of microRNA in development and progression of atherosclerosis.
authors.affiliation: Department of Physiologic Nursing, University of California, San Francisco, School of Nursing, San Francisco, CA 94143, USA. eflowers@ucsf.edu
authors.forename: Elena
authors.initials: E
authors.lastname: Flowers
authors.forename: Erika Sivarajan
authors.initials: ES
authors.lastname: Froelicher
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Aouizerat
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs