title: [Tumor markers for hepatocellular carcinoma].
abstract: Three tumor markers for hepatocellular carcinoma (HCC) are available in Japan: alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonists-II (PIVKA-II), and Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3). Although AFP has drawbacks in its specificity, it is widely utilized in treatment evaluation and prognosis prediction. PIVKA-II is a unique marker that does not correlate with AFP value and can predict microvascular invasion. AFP-L3 is a highly specific marker and strong predictor of poor prognosis. These three markers are indispensable in every aspect of clinical practice of hepatocellular carcinoma including surveillance, diagnosis, treatment evaluation, and prognosis prediction.
authors.affiliation: Department of Gastroenterology, The University of Tokyo Graduate School of Medicine.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tateishi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Enooku
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Shiina
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
mesh_terms: D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000628:therapy; D011498:Protein Precursors / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin