title: TOR links starvation responses to telomere length maintenance.
abstract: Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: Martin
authors.initials: M
authors.lastname: Kupiec
authors.forename: Ronit
authors.initials: R
authors.lastname: Weisman
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*; D059505:Telomere Homeostasis; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C071664:GLN3 protein, S cerevisiae; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C107277:Wtm1 protein, S cerevisiae; C520769:YKU70 protein, S cerevisiae; C520770:YKU80 protein, S cerevisiae; D058570:TOR Serine-Threonine Kinases