title: ROS1 gene rearrangement is identified in NSCLC.
abstract: MAJOR FINDING: ROS1 chromosomal rearrangements define a molecular subtype of NSCLC.
  
  
  CONCLUSIONS
  ROS1 rearrangements tend to occur in younger, non-smoking NSCLC patients.
  
  
  CONCLUSIONS
  ROS1-positive NSCLC patients may benefit from crizotinib therapy.
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human