title: The role of small GTPases in neuronal morphogenesis and polarity.
abstract: The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation.
authors.affiliation: Faculty of Sciences, Laboratory of Cell and Neuronal Dynamics, Department of Biology and Institute for Cell Dynamics and Biotechnology, Universidad de Chile, Santiago, Chile. chrgonza@uchile.cl
authors.forename: Christian
authors.initials: C
authors.lastname: Gonzalez-Billault
authors.forename: Pablo
authors.initials: P
authors.lastname: Muñoz-Llancao
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Henriquez
authors.forename: José
authors.initials: J
authors.lastname: Wojnacki
authors.forename: Cecilia
authors.initials: C
authors.lastname: Conde
authors.forename: Alfredo
authors.initials: A
authors.lastname: Caceres
mesh_terms: D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008954:Models, Biological; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D009024:Morphogenesis; D009474:Neurons / Q000166:cytology* / Q000201:enzymology*
chemical_list: D020559:Monomeric GTP-Binding Proteins