title: Palladium-catalyzed desymmetrization of silacyclobutanes with alkynes: enantioselective synthesis of silicon-stereogenic 1-sila-2-cyclohexenes and mechanistic considerations.
abstract: A palladium-catalyzed enantioselective desymmetrization of silacyclobutanes with alkynes has been developed to give silicon-stereogenic 1-sila-2-cyclohexenes with high enantioselectivity. The products thus obtained undergo further derivatizations with complete stereoselectivity, and a new catalytic cycle involving alkyne coordination (oxidative cyclization)-transmetalation (σ-bond metathesis)-reductive elimination has also been proposed.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. shintani@kuchem.kyoto-u.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Kohei
authors.initials: K
authors.lastname: Moriya
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi