title: The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction.
abstract: Neuronal calcium sensors (NCS) readily bind calcium and undergo conformational changes enabling them to interact and regulate specific target molecules. These interactions lead to dynamic alterations in protein trafficking that significantly impact upon synaptic function. Emerging evidence suggests that NCS and alterations in Ca(2+) mobilization modulate glutamate receptor trafficking, subsequently determining the expression of different forms of synaptic plasticity. In this review, we aim to discuss the functional relevance of NCS in protein trafficking and their emerging role in synaptic plasticity. Their significance within the concept of "translational neuroscience" will also be highlighted, by assessing their potential as key molecules in neurodegeneration.
authors.affiliation: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK.
authors.forename: Talitha L
authors.initials: TL
authors.lastname: Kerrigan
authors.forename: Whitcomb
authors.initials: W
authors.lastname: Daniel J
authors.forename: Philip L
authors.initials: PL
authors.lastname: Regan
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho