title: Rosette-forming glioneuronal tumour of the lateral ventricle in a patient with neurofibromatosis 1.
abstract: We report a 33-year-old man with neurofibromatosis type 1 (NF-1) with a rosette-forming glioneuronal tumour (RGNT) in the lateral ventricle. The patient had been treated with radiotherapy and chemotherapy for a typical juvenile pilocytic astrocytoma of the hypothalamus seven years prior. MRI revealed a contrast-enhancing mass in the anterior horn of the left lateral ventricle. Histological examination demonstrated two distinct regions characterised by a rosette-forming neurocytic component and an astrocytic predominant component. Immunohistochemical studies showed glial fibrillary acidic protein and S-100 positivity in the astrocytic component and neuron-specific enolase was positive in the neurocytic cells. Although RGNT has been reported at other sites within the central nervous system, this report documents a previously undescribed lateral ventricular location of a rare RGNT in an asymptomatic patient with NF-1.
authors.affiliation: Sydney Medical School, Darlington campus, University of Sydney, New South Wales, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Kemp
authors.forename: A
authors.initials: A
authors.lastname: Achan
authors.forename: T
authors.initials: T
authors.lastname: Ng
authors.forename: M A J
authors.initials: MA
authors.lastname: Dexter
mesh_terms: D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology*; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology*; D012397:Rosette Formation