title: Immune epitope database analysis resource.
abstract: The immune epitope database analysis resource (IEDB-AR: http://tools.iedb.org) is a collection of tools for prediction and analysis of molecular targets of T- and B-cell immune responses (i.e. epitopes). Since its last publication in the NAR webserver issue in 2008, a new generation of peptide:MHC binding and T-cell epitope predictive tools have been added. As validated by different labs and in the first international competition for predicting peptide:MHC-I binding, their predictive performances have improved considerably. In addition, a new B-cell epitope prediction tool was added, and the homology mapping tool was updated to enable mapping of discontinuous epitopes onto 3D structures. Furthermore, to serve a wider range of users, the number of ways in which IEDB-AR can be accessed has been expanded. Specifically, the predictive tools can be programmatically accessed using a web interface and can also be downloaded as software packages.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Kim
authors.forename: Julia
authors.initials: J
authors.lastname: Ponomarenko
authors.forename: Zhanyang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Dorjee
authors.initials: D
authors.lastname: Tamang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Jason
authors.initials: J
authors.lastname: Greenbaum
authors.forename: Claus
authors.initials: C
authors.lastname: Lundegaard
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sette
authors.forename: Ole
authors.initials: O
authors.lastname: Lund
authors.forename: Philip E
authors.initials: PE
authors.lastname: Bourne
authors.forename: Morten
authors.initials: M
authors.lastname: Nielsen
authors.forename: Bjoern
authors.initials: B
authors.lastname: Peters
mesh_terms: D018985:Epitopes, B-Lymphocyte / Q000737:chemistry*; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D020407:Internet; D010455:Peptides / Q000276:immunology; D012984:Software; D040681:Structural Homology, Protein
chemical_list: D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides