title: Myoepithelial Carcinoma: A Rare Neoplasm of the Breast.
abstract: BACKGROUND: Malignant myoepitheliomas of the breast are extremely rare. There has been a limited number of published reports of myoepithelial carcinomas originating from the breast.  CASE REPORT: We describe a malignant myoepithelioma of the breast in a 56-year-old woman. Histological examination showed polygonal epithelioid cells and spindle cells with moderate to marked nuclear atypia. Immunohistochemistry showed reactivity in the spindle cells for smooth muscle actin, cytokeratin (AE1/AE3), and p63, indicating a myoepithelial cell lineage of tumor cells. The patient underwent radical surgical excision of the lesion and axillary lymph node dissection. She demonstrated no evidence of recurrence over an 11-month follow-up.  CONCLUSIONS: We suggest myoepithelial carcinomas of the breast be managed with appropriate surgical clearance. A multidisciplinary approach is usually required.
authors.affiliation: Department of Surgery, Chi Mei Medical Center, Yong Kang City Tainan, Taiwan, R.O.C.
authors.forename: Kuo-Chun
authors.initials: KC
authors.lastname: Liao
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Lee
authors.forename: Ming-Jenn
authors.initials: MJ
authors.lastname: Chen