title: Synthesis of 3,4-dihalogenated furan-2-(5H)-ones by electrophilic cyclization of 4-hydroxy-2-alkynoates.
abstract: Functionalized 3,4-dihalogenated furan-2(5H)-ones can be readily prepared in moderate to good yields by treating 4-hydroxy-4-arylbut-2-ynoate derivatives with ICl, IBr, and I(2). Both halogen atoms of the electrophile are incorporated in the product. The resulting halides can further afford polycyclic aromatic compounds using known palladium-catalyzed coupling reactions.
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhu
authors.forename: Li-Jing
authors.initials: LJ
authors.lastname: Wang
authors.forename: Ke-Gong
authors.initials: KG
authors.lastname: Ji
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000737:chemistry
chemical_list: D000480:Alkynes; D005663:Furans; D006219:Halogens; D020005:Propanols; D010165:Palladium; C028255:propargyl alcohol; C039281:furan