title: Regional gray matter changes in obsessive-compulsive disorder: relationship to clinical characteristics.
abstract: Regional brain volumes were compared between 23 participants with obsessive-compulsive disorder (OCD) and 36 healthy controls using magnetic resonance imaging with voxel-based morphometry. A volumetric decrease in OCD was found in the right mediofrontal cortex. An increase was found in the left temporoparietal cortex. Volume alterations were related to symptom severity and age of onset.
authors.affiliation: Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany. exnerc@uni-leipzig.de
authors.forename: Cornelia
authors.initials: C
authors.lastname: Exner
authors.forename: Ulrike
authors.initials: U
authors.lastname: Zetsche
authors.forename: Vera
authors.initials: V
authors.lastname: Martin
authors.forename: Winfried
authors.initials: W
authors.lastname: Rief
authors.forename: Andreas
authors.initials: A
authors.lastname: Jansen
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D036421:Nerve Fibers, Unmyelinated / Q000473:pathology*; D059906:Neuroimaging; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*; D009929:Organ Size