title: Pharmacologic issues in management of chronic disease.
abstract: A significant portion of the adult population uses one or more medications on a regular basis to manage chronic conditions. As the number of medications that patients are prescribed increases, an increase in pharmacologic-related issues and complications may occur, such as polypharmacy, inappropriate prescribing, medication nonadherence and nonpersistence, and adverse drug reactions and events. Risk factors and consequences of these issues have been identified and are discussed in this article. In addition, a review is presented of the numerous methods that have been evaluated to help prevent and minimize these pharmacologic issues in the management of chronic disease.
authors.affiliation: Department of Pharmacy Practice, Jefferson School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Suite 1540, Philadelphia, PA 19107, USA. gina.desevo@jefferson.edu
authors.forename: Gina
authors.initials: G
authors.lastname: DeSevo
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Klootwyk
mesh_terms: D000465:Algorithms; D002908:Chronic Disease; D019468:Disease Management; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D057970:Inappropriate Prescribing / Q000706:statistics & numerical data*; D055118:Medication Adherence; D004364:Pharmaceutical Preparations; D019338:Polypharmacy; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D055553:Prescription Drugs; D012307:Risk Factors
chemical_list: D004364:Pharmaceutical Preparations; D055553:Prescription Drugs