title: Adult leptomeningeal cerebellar heterotopia in contact with the posterior inferior cerebellar artery.
abstract: A leptomeningeal mass was encountered during microdissection of a 63-year-old male cadaver, located dorsal to the left side of the medulla oblongata. The structure was compressing the posterior inferior cerebellar artery (PICA) and was composed of cerebellar-like tissue. Immunohistochemistry for S100 protein, glial fibrillary acidic protein and neurofilaments (NF, the triplet proteins and the 200 kD antibody) on paraffin-embedded samples confirmed the cerebellar heterotopion. Abundant Lewy-like degenerative bodies were also identified within the heterotopion; they were positive for the NF triplet and negative for the 200 kD neurofilaments. Purkinje cells were rare. This is the first evidence of a leptomeningeal cerebellar heterotopia in contact with PICA in adult. Such subtentorial heterotopias, even if rare, should be searched for during clinical, paraclinical and surgical explorations of the posterior fossa.
authors.affiliation: Discipline of Anatomy, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Bd. Eroilor Sanitari, Bucharest, Romania. anatomon@gmail.com
authors.forename: Mugurel Constantin
authors.initials: MC
authors.lastname: Rusu
mesh_terms: D001158:Arteries / Q000033:anatomy & histology*; D002102:Cadaver; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology*; D002828:Choristoma / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000473:pathology; D008297:Male; D008578:Meninges / Q000473:pathology*; D042282:Microdissection; D008875:Middle Aged
chemical_list: D005904:Glial Fibrillary Acidic Protein