title: Mitral bioprosthetic valve stenosis in a patient with antiphospholipid antibody syndrome and systemic lupus erythematosus.
abstract: A 45-year-old woman with antiphospholipid antibody syndrome (APS) and systemic lupus erythematosus was admitted because of severe dyspnea. She had undergone mitral valve replacement (MVR) using a Mosaic bioprosthesis for infective endocarditis 9 years previously. She developed congestive heart failure secondary to mitral bioprosthetic valve stenosis resulting from relatively early structural valve deterioration. She underwent a second MVR using a mechanical valve prosthesis. The explanted bioprosthesis showed marked pannus formation and mineralization with fibrin thrombus formation, especially on the outflow surfaces of the leaflets. After the second operation, she was discharged without APS-related thromboembolic events under meticulous anticoagulant and antiplatelet therapies.
authors.affiliation: Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan. m3_514@yahoo.co.jp
authors.forename: Akimasa
authors.initials: A
authors.lastname: Morisaki
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Hirai
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Hosono
authors.forename: Masanori
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakahira
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Seo
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Suehiro
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications*; D001705:Bioprosthesis; D002114:Calcinosis / Q000150:complications; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006350:Heart Valve Prosthesis; D006801:Humans; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000150:complications*; D011475:Prosthesis Failure / Q000009:adverse effects*; D012086:Reoperation