title: Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene.
abstract: The relation between the use of tamoxifen and gynecologic tumors has been documented. In this case, a 58-year-old postmenopausal woman had been treated with tamoxifen for 5 years followed by toremifene for 1.5 years due to the presence of stage II estrogen receptor-positive breast cancer. The patient was found to have a stage Ic granulosa cell tumor of the ovary despite undergoing annual gynecologic examinations. This report presents a case of granulosa cell tumor of the ovary after the long-term use of tamoxifen and toremifene.
authors.affiliation: Department of Obstetrics and Gynecology, National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan. tomohito@ommc-hp.jp
authors.forename: Tomohito
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.forename: Masahide
authors.initials: M
authors.lastname: Ohmichi
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000139:chemically induced*; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects*; D017312:Toremifene / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D017312:Toremifene