title: TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.
abstract: BACKGROUND
  Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent.
  
  
  METHODS
  We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed.
  
  
  RESULTS
  Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk.
  
  
  CONCLUSIONS
  Minor allele carriers of two genetic variants (rs1800469 and rs1982073) in TGFB1 have a 15% increased risk of CHD.
authors.affiliation: Division of Human Nutrition, Wageningen University and Research Center, PO Box 8129, 6700, EV, Wageningen, The Netherlands. kevin.lu@wur.nl
authors.forename: Yingchang
authors.initials: Y
authors.lastname: Lu
authors.forename: Jolanda M A
authors.initials: JM
authors.lastname: Boer
authors.forename: Roza M
authors.initials: RM
authors.lastname: Barsova
authors.forename: Olga
authors.initials: O
authors.lastname: Favorova
authors.forename: Anuj
authors.initials: A
authors.lastname: Goel
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
authors.forename: Edith J M
authors.initials: EJ
authors.lastname: Feskens
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1