title: [Universal influenza vaccines: developments, prospects for use].
abstract: The review analyzes the developments of genetic engineering influenza vaccines based on the conservative epitopes of viral surface proteins, such as hemagglutinin, neuraminidase, ectodomain of matrix protein M2. It estimates the capacity of the vaccines to induce an immune response to a wide variety of influenza viruses, considers ways to increase the immunogenicity and protective properties of the vaccines, based on the conservative epitopes of viral surface proteins, and prospects for their use to prevent influenza.
authors.forename: L M
authors.initials: LM
authors.lastname: Tsybalova
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D017124:Conserved Sequence; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006388:Hemagglutinins / Q000235:genetics / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000235:genetics / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control* / Q000821:virology; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic; D014763:Viral Matrix Proteins / Q000235:genetics / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D000086082:Viroporin Proteins
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D006388:Hemagglutinins; D007252:Influenza Vaccines; D009439:Neuraminidase; D014614:Vaccines, Synthetic; D014763:Viral Matrix Proteins; D014764:Viral Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins