title: Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders.
abstract: We examined clinicopathologic findings in 17 cases of peripheral T-cell lymphoma, follicular variant (f-PTCL), and compared these findings with angioimmunoblastic T-cell lymphoma (AITL) to determine whether they were identical to the spectrum of changes seen in AITL and how each of the findings in f-PTCL were related to the characteristics of AITL. Almost all f-PTCL cases showed pathologic characteristics of AITL and immunohistochemical positivities in lymphoma cells for CD4, CD10, Bcl-6, PD-1, and CXCL13. Except for pathologic characteristics, clinicopathologic findings in f-PTCL had few significant differences from AITL. The positive rate for Bcl-6 expression in neoplastic cells was significantly associated with the frequency of polymorphic infiltrates, vascular proliferation, B-immunoblasts, clear cells, Epstein-Barr virus-positive lymphocytes, hepatosplenomegaly, and skin rash. Our study confirmed the continuity between f-PTCL and AITL. Moreover, Bcl-6 expression in f-PTCL was statistically associated with the characteristics of AITL.
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, 67 Asahimachi, Kurume, Fukuoka, 830 0011, Japan. miyoshi_hiroaki@med.kurume-u.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Kensaku
authors.initials: K
authors.lastname: Sato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Niino
authors.forename: Fumiko
authors.initials: F
authors.lastname: Arakawa
authors.forename: Yoshizo
authors.initials: Y
authors.lastname: Kimura
authors.forename: Junichi
authors.initials: J
authors.lastname: Kiyasu
authors.forename: Masanori
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Maki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Okada
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugita
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D054382:Chemokine CXCL13 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D005076:Exanthema; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D059785:Karyotype; D008224:Lymphoma, Follicular / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6; D016019:Survival Analysis
chemical_list: D015703:Antigens, CD; C084103:BCL6 protein, human; D054382:Chemokine CXCL13; D004268:DNA-Binding Proteins; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D051560:Proto-Oncogene Proteins c-bcl-6