title: Improved outcome in pediatric AML due to augmented supportive care.
abstract: We conducted a retrospective review of patients treated following the MRC acute myeloid leukemia (AML) 10 protocol to determine if supportive care measures sequentially introduced by our institution led to a significant improvement in treatment-related mortality (TRM) in newly diagnosed pediatric patients with AML. Patients were partitioned based on supportive care measures into era1, from 1996 to 2002 (n = 20), and era2, from 2003 to 2011 (n = 40). The introduced supportive care measures reduced the TRM from 23.4% in era1 to 2.5% in era2 (P = 0.034). The results demonstrate that supportive care is a significant factor in determining the outcome of childhood AML.
authors.affiliation: Princess Noorah Oncology Center, King Saud Bin Abdulaziz University, King Abdulaziz Medical City, Jeddah, Saudi Arabia. jastaniahwa@ngha.med.sa
authors.forename: Wasil
authors.initials: W
authors.lastname: Jastaniah
authors.forename: Mohammed Burhan
authors.initials: MB
authors.lastname: Abrar
authors.forename: Taha M
authors.initials: TM
authors.lastname: Khattab
mesh_terms: D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate