title: Unprecedented "In Water" imidazole carbonylation: paradigm shift for preparation of urea and carbamate.
abstract: The first "In Water" imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained in high purity by filtration, resulting in a simple and scalable method.
authors.affiliation: Department of Medicinal Chemistry, Nycomed Pharma Pvt. Ltd., 29-31 Suren Road, Andheri east, Mumbai-400 092, India. kamleshpadiya@lupinpharma.com
authors.forename: Kamlesh J
authors.initials: KJ
authors.lastname: Padiya
authors.forename: Sandip
authors.initials: S
authors.lastname: Gavade
authors.forename: Bhavana
authors.initials: B
authors.lastname: Kardile
authors.forename: Manojkumar
authors.initials: M
authors.lastname: Tiwari
authors.forename: Swapnil
authors.initials: S
authors.lastname: Bajare
authors.forename: Madhav
authors.initials: M
authors.lastname: Mane
authors.forename: Vivek
authors.initials: V
authors.lastname: Gaware
authors.forename: Shaji
authors.initials: S
authors.lastname: Varghese
authors.forename: Dipak
authors.initials: D
authors.lastname: Harel
authors.forename: Suresh
authors.initials: S
authors.lastname: Kurhade
mesh_terms: D000588:Amines / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000588:Amines; D002219:Carbamates; D007093:Imidazoles; D013859:Thiocarbamates; D014867:Water; D014508:Urea