title: Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers.
abstract: Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6- or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kallitsakis
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
authors.forename: Konstantinos E
authors.initials: KE
authors.lastname: Litinas
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines / Q000737:chemistry*
chemical_list: D003374:Coumarins; D016166:Free Radical Scavengers; D009705:Nucleosides; D011687:Purines; C030985:purine