title: [Study of dinitrosyl-iron complexes pharmacokinetics and accumulation in depot in rat organs].
abstract: Protein-bound dinitrosyl-iron complexes (DNIC) in rat whole blood and organs were studied after intravenous injection of this substance with glutathione ligand (DNIC-GH). The effect of DNIC-GH injection on NO level (including NO physiological forms) in hydrophobic areas of rat tissues was also studied in normal physiological blood circulation condition. It has been shown, that after DNIC-GH injection the concentration of protein-bound DNICs in rat whole blood and organs rapidly reached maximum values, and then gradually decreased, that pointed to decomposition of DNIC molecules, coupled with NO release. At the beginning of the experiment the rates of DNIC decay in rat heart and lung were substantially higher, as compared with those in liver and kidney. By spin trappping it has been demonstrated that DNIC-GH, as a source of NO physiological forms (including S-nitrosothiols), in normal physiological blood circulation influence heart more selectively, as compared with the other organs.
authors.forename: A A
authors.initials: AA
authors.lastname: Timoshin
authors.forename: V L
authors.initials: VL
authors.lastname: Lakomkin
authors.forename: É K
authors.initials: ÉK
authors.lastname: Ruuge
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000818:Animals; D005978:Glutathione / Q000493:pharmacokinetics* / Q000494:pharmacology; D007501:Iron / Q000493:pharmacokinetics* / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D009589:Nitrogen Oxides / Q000493:pharmacokinetics* / Q000494:pharmacology; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione