title: Clinical significance of serum growth-regulated oncogene alpha (GROalpha) in patients with gynecological cancer.
abstract: OBJECTIVE
  To assess the clinical relevance of serum growth-regulated oncogene alpha (GROalpha) levels in gynecological cancer, we investigated its concentration in distinguishing patients with cervical cancer, endometrial cancer, ovarian cancer, benign ovarian tumor and control.
  
  
  METHODS
  Preoperative serum GROalpha levels were measured in women with cervical cancer (n=46), endometrial cancer (n=39), ovarian cancer (n=124), benign ovarian tumors (n=52), and normal controls (n=38) using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Statistical analyses showed that the serum GROalpha concentration was significantly elevated in the cervical cancer, endometrial cancer and ovarian cancer patients compared with controls. Using GROalpha levels, the receiver operating characteristic (ROC) of cervical cancer (AUC approximately 0.775), endometrial cancer (AUC approximately 0.799), ovarian cancer (AUC approximately 0.749) and benign ovarian tumors (AUC approximately 0.568) vs. controls were identified.
  
  
  CONCLUSIONS
  Our findings suggest that serum GROalpha measurement as a molecular marker might contribute to detection and diagnosis of gynecological cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nishikawa
authors.forename: N
authors.initials: N
authors.lastname: Suzumori
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: H
authors.initials: H
authors.lastname: Nishikawa
authors.forename: A
authors.initials: A
authors.lastname: Arakawa
authors.forename: M
authors.initials: M
authors.lastname: Sugiura-Ogasawara
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000097:blood; D002288:Adenocarcinoma, Mucinous / Q000097:blood; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood*; D018269:Carcinoma, Endometrioid / Q000097:blood; D054360:Chemokine CXCL1 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D010048:Ovarian Cysts / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood*; D012372:ROC Curve; D018709:Statistics, Nonparametric; D002583:Uterine Cervical Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D054360:Chemokine CXCL1