title: Benzyl 2-β-glucopyranosyloxybenzoate, a new phenolic acid glycoside from Sarcandra glabra.
abstract: From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B₁ (2), 5-O-caffeoylshikimic acid (3), (-)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol (4), (-)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′- and 4-O-α-D-glucopyranoside (5-7), and (-)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC₅₀ value of 2.53 and 1.85 μM, respectively.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wu
authors.forename: Xiaoru
authors.initials: X
authors.lastname: Hu
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
authors.forename: Shilin
authors.initials: S
authors.lastname: Chen
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
mesh_terms: D029624:Ferns / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D006027:Glycosides; D062385:Hydroxybenzoates; C575010:benzyl-2-beta-glucopyranosyloxybenzoate; C017616:phenolic acid