title: Efficacy of silver treated catheters for haemodialysis in preventing bacterial adhesion.
abstract: The growing resistance of many strains of bacteria to antibiotics and antiseptics is becoming a serious problem in medicine. Nano-silver is one of the most prominent products in medicine because it exhibits unusual physicochemical properties and a strong biological activity. In this work an innovative silver deposition technology was applied to temporary polyurethane catheters for haemodialysis. The working conditions of catheters were reproduced through laboratory equipment that ensured the flow of deionized water and simulated body fluid inside the lumina at corporeal temperature. The growth and the adhesion of Staphylococcus aureus on the surface of the device were studied through fluorescence microscopy. ICP-AES was adopted to calculate the amount of silver released from the substrate. The stability of the coating during the whole working life of the device was demonstrated through thermo-gravimetric analysis.
authors.affiliation: Department of Engineering for Innovation, University of Salento, Lecce, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Paladini
authors.forename: M
authors.initials: M
authors.lastname: Pollini
authors.forename: A
authors.initials: A
authors.lastname: Talà
authors.forename: P
authors.initials: P
authors.lastname: Alifano
authors.forename: A
authors.initials: A
authors.lastname: Sannino
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001422:Bacterial Adhesion / Q000187:drug effects*; D055499:Catheter-Related Infections / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012834:Silver