title: Vascular endothelial growth factor -634G/C polymorphism associated with osteonecrosis of the femoral head in a Chinese population.
abstract: An impeded blood flow through the femoral head is incriminated in the etiopathogenesis of osteonecrosis of the femoral head (ONFH). Vascular endothelial growth factor (VEGF) is a strong angiogenic protein and also plays a role in the formation of cartilage and bone. The aim of this study was to evaluate the association of VEGF -634G/C polymorphism with ONFH in a Chinese population. A total of 220 unrelated patients with nontraumatic ONFH and 220 unrelated control subjects were consecutively enrolled in a hospital-based case-control study. A polymerase chain reaction-restriction fragment length polymorphism analysis was used to detect the VEGF -634G/C genotype. Patients with ONFH had a significantly higher frequency of the CC genotype (odds ratio=1.64, 95% confidence interval=1.03, 2.60; p=0.04) than controls. There were no significant associations between any genotypes and the cause of ONFH. Our results support the hypothesis that the VEGF -634CC genotype is a risk factor of ONFH in the Chinese population. However, current results should be validated prospectively in larger cohorts.
authors.affiliation: Department of Orthopedics, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Cao
authors.forename: Dawei
authors.initials: D
authors.lastname: Wang
authors.forename: Guijun
authors.initials: G
authors.lastname: Yao
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Bi
mesh_terms: D000328:Adult; D044466:Asian People; D001783:Blood Flow Velocity; D002681:China / Q000453:epidemiology; D005260:Female; D005270:Femur Head / Q000098:blood supply / Q000378:metabolism; D005271:Femur Head Necrosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A