title: Transcription: another mark in the tail.
abstract: The C-terminal domain (CTD) of the largest RNA polymerase II (RNAPII) subunit undergoes dynamic phosphorylation to support transcription-associated events and drive the transcription cycle. In mammalian cells, it comprises 52 repeats of the heptapeptide sequence Tyr(1)–Ser(2)–Pro(3)–Thr(4)–Ser(5)–Pro(6)–Ser(7). While important functions for Ser(2)-, Ser(5)-, and Ser(7)-phosphorylation have previously been described, a new report in The EMBO Journal now suggests an unexpectedly crucial role for Thr(4) phosphorylation as well.
authors.affiliation: Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, South Mimms, UK. j.svejstrup@cancer.org.uk
authors.forename: Jesper Q
authors.initials: JQ
authors.lastname: Svejstrup
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D013912:Threonine / Q000378:metabolism*; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins; D000097868:Polo-like Kinases
chemical_list: D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II; D013912:Threonine; D025521:Tumor Suppressor Proteins; C486256:PLK3 protein, human; D000097868:Polo-like Kinases