title: [Evaluation study of clinical and neurobiological efficacy of EMDR in patients suffering from post-traumatic stress disorder].
abstract: Strong evidences support use of EMDR in patients suffering from post-traumatic stress disorder (PTSD).
  
  
  OBJECTIVE
  To evaluate clinical and neurobiological-structural efficacy of EMDR on drug-naïve PTSD without comorbidity.
  
  
  METHODS
  We made clinical evaluation and hippocampal volume measurement by MRI on 29 subjects suffering from PTSD and on 30 healthy control-subjects. Then, patients were treated with EMDR and after three months of psychotherapy the clinical evaluation and the MRI exam were replied.
  
  
  CONCLUSIONS
  Our results demonstrated that the diagnosis of PTSD was no more possible on all the patients who terminated the psychotherapy (n=18). At the same time, all the patients showed an average increase of 6% in hippocampal volumes.
  
  
  CONCLUSIONS
  Our reaserach suggests that EMDR treatment correlates not only with a significant improvement of symptoms of PTSD, but also with a significant increase of hippocampal volumes.
authors.affiliation: Dipartimento di Neuroscience, Sezione di Psichiatria, Università di Siena. letizia.bossini@gmail.com
authors.forename: Letizia
authors.initials: L
authors.lastname: Bossini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Casolaro
authors.forename: Emiliano
authors.initials: E
authors.lastname: Santarnecchi
authors.forename: Claudia
authors.initials: C
authors.lastname: Caterini
authors.forename: Despina
authors.initials: D
authors.lastname: Koukouna
authors.forename: Isabel
authors.initials: I
authors.lastname: Fernandez
authors.forename: Andrea
authors.initials: A
authors.lastname: Fagiolini
mesh_terms: D000328:Adult; D057169:Eye Movement Desensitization Reprocessing; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000628:therapy*