title: Outcome of breast lesions detected at screening ultrasonography.
abstract: OBJECTIVE
  To assess the final outcome of breast lesions detected during screening ultrasonography (US) and categorized by BI-RADS final assessment.
  
  
  METHODS
  During a 1-year period, 3817 consecutive asymptomatic women with negative findings at both clinical breast examinations and mammography underwent bilateral whole breast US and BI-RADS categories were provided for US-detected breast lesions. The reference standard was a combination of histology and US follow-up (≥12 months), and the final outcomes of 1192 US-detected lesions were analyzed.
  
  
  RESULTS
  Of 904 category 2 lesions, 890 remained stable for 12-60 months. Biopsies of 14 lesions revealed no malignancies (NPV=100%). Of 247 category 3 lesions, 232 remained stable for 12-60 months. Biopsies of 15 lesions revealed 2 malignancies, which were diagnosed within 6 months of the index examination and were node negative (NPV=99.2%). Of 41 category 4 lesions, biopsies of 38 lesions revealed 5 malignancies (PPV=12.2%), and 3 remained stable for 37-51 months. No US-detected lesion was classified as category 5.
  
  
  CONCLUSIONS
  The rates of malignancy for US-detected BI-RADS categories 2, 3, and 4 lesions were 0%, 0.8%, and 12.2%, respectively. The final assessment of US BI-RADS categorization showed it to be an appropriate predictor of malignancy for screening US-detected breast lesions.
authors.affiliation: Department of Radiology, Seoul Metropolitan Government Seoul National University, Seoul National University Hospital, Boramae Medical Center, 41, Boramae-gil, Dongjak-gu, Seoul 156-707, Republic of Korea. winnerkim89@gmail.com
authors.forename: Seung Ja
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Chang
authors.forename: Nariya
authors.initials: N
authors.lastname: Cho
authors.forename: Se-Yeong
authors.initials: SY
authors.lastname: Chung
authors.forename: Wonshik
authors.initials: W
authors.lastname: Han
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Moon
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D056910:Republic of Korea / Q000453:epidemiology; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary; D055815:Young Adult