title: Molecular characterisation of sinonasal carcinomas and their clinical implications.
abstract: Sinonasal carcinomas are rare tumours with an unfavourable prognosis whose management is difficult and complex, leading to high morbidity and mortality despite improvements in the field of surgery and radiotherapy. An elevated number of these tumours can be attributed to occupational exposure. In comparison with other head and neck malignancies, studies of molecular changes in these tumours are infrequent. This review was focused on findings about the epidemiology and molecular and phenotypic characterisation of sinonasal carcinomas, which can potentially be useful for diagnosis and treatment. The increasing knowledge about the molecular biology that underlies their carcinogenesis may help to identify precursor lesions, prognostic markers and markers that predict chemoradiotherapy response and, finally, to identify potential molecular targets that will expand treatment options.
authors.affiliation: Servicio de Otorrinolaringología, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Asturias, España. flopez_1981@yahoo.es
authors.forename: Fernando
authors.initials: F
authors.lastname: López
authors.forename: José Luis
authors.initials: JL
authors.lastname: Llorente
authors.forename: María
authors.initials: M
authors.lastname: Costales
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Inclán
authors.forename: Jhudit
authors.initials: J
authors.lastname: Pérez-Escuredo
authors.forename: César
authors.initials: C
authors.lastname: Alvarez-Marcos
authors.forename: Mario
authors.initials: M
authors.lastname: Hermsen
authors.forename: Carlos
authors.initials: C
authors.lastname: Suárez
mesh_terms: D006801:Humans; D025202:Molecular Diagnostic Techniques; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics