title: A plant microRNA regulates the adaptation of roots to drought stress.
abstract: Plants tend to restrict their horizontal root proliferation in response to drought stress, an adaptive response mediated by the phytohormone abscisic acid (ABA) in antagonism with auxin through unknown mechanisms. Here, we found that stress-regulated miR393-guided cleavage of the transcripts encoding two auxin receptors, TIR1 and AFB2, was required for inhibition of lateral root growth by ABA or osmotic stress. Unlike in the control plants, the lateral root growth of seedlings expressing miR393-resistant TIR1 or AFB2 was no longer inhibited by ABA or osmotic stress. Our results indicate that miR393-mediated attenuation of auxin signaling modulates root adaptation to drought stress.
authors.affiliation: Donald Danforth Plant Science Center, St. Louis, MO 63132, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Zhuofu
authors.initials: Z
authors.lastname: Li
authors.forename: Liming
authors.initials: L
authors.lastname: Xiong
mesh_terms: D000040:Abscisic Acid / Q000502:physiology; D000222:Adaptation, Physiological / Q000235:genetics*; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D020029:Base Pairing; D001483:Base Sequence; D055864:Droughts; D044783:F-Box Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D035683:MicroRNAs / Q000502:physiology*; D009997:Osmotic Pressure; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D018517:Plant Roots / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D030821:Plants, Genetically Modified; D034622:RNA Interference; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013312:Stress, Physiological / Q000235:genetics*
chemical_list: D029681:Arabidopsis Proteins; D044783:F-Box Proteins; C559857:MIRN393 microRNA, Arabidopsis; D035683:MicroRNAs; D010940:Plant Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C501405:TIR1 protein, Arabidopsis; C046131:auxin receptor, plant; D000040:Abscisic Acid