title: AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development.
authors.affiliation: Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
authors.forename: Denzil
authors.initials: D
authors.lastname: Bernard
authors.forename: Yujun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Shaomeng
authors.initials: S
authors.lastname: Wang
mesh_terms: D000085:Acetates / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D006801:Humans; D010881:Piperidones / Q000138:chemical synthesis*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C575269:2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid; D000085:Acetates; D000970:Antineoplastic Agents; D010881:Piperidones; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2