title: Teratoma with somatic-type malignant components of the testis. A review and an update.
abstract: Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.
authors.affiliation: Department of Pathology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Gregor
authors.initials: G
authors.lastname: Mikuz
authors.forename: Maurizio
authors.initials: M
authors.lastname: Colecchia
mesh_terms: D006801:Humans; D008297:Male; D011379:Prognosis; D013724:Teratoma / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D013736:Testicular Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*