title: Efficient, divergent synthesis of cryptophycin unit A analogues.
abstract: A flexible and divergent synthesis of cryptophycin unit A analogues is described. This method relies on iridium-catalysed stereo- and enantioselective crotylation and chemoselective one-pot oxidative olefination to access common intermediate . Heck, cross metathesis, and Suzuki-Miyaura reactions are illustrated for the generation of methyl ester unit A analogues .
authors.affiliation: Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, and Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, United States.  sdlarsen@umich.edu; davidhs@umich.edu.
authors.forename: Kyle L
authors.initials: KL
authors.lastname: Bolduc
authors.forename: Scott D
authors.initials: SD
authors.lastname: Larsen
authors.forename: David H
authors.initials: DH
authors.lastname: Sherman