title: Role of space provision in regeneration of localized two-wall intrabony defects using periosteal pedicle graft as an autogenous guided tissue membrane.
abstract: BACKGROUND
  Marginal pedicle periosteum (MPP) has been used as a rigid membrane in guided tissue regeneration (GTR) for osseous defects. The present study aims to study the effect of space provision by an alloplastic graft material in bone defect area (BDA) reduction of 2-wall defects.
  
  
  METHODS
  Twenty interproximal intrabony 2-wall defects in healthy non-smoking patients with chronic periodontitis were randomly divided in control (group 1, periosteum alone) and experimental (group 2, periosteum with alloplastic graft material) groups. Measurements of probing depth (PD), clinical attachment level (CAL), and radiographic BDA were done at the baseline and 6-month postoperative evaluations.
  
  
  RESULTS
  The 6-month postoperative assessment showed clinical and radiographic improvements with PD reduction, CAL gain, and changes in BDA in both groups, which was statistically significant compared with baseline (P <0.05). However, BDA reduction was statistically greater in group 2 (48.88% ± 18.61%) compared with group 1 (14.08% ± 12.97%) at the 6-month follow-up (P = 0.009).
  
  
  CONCLUSIONS
  Within the limitations of this study, it can be concluded that space provision by an alloplastic graft material increases the regenerative potential of MPP as a GTR membrane and results in increased defect fill.
authors.affiliation: Department of Periodontics, Faculty of Dental Sciences, King George's Medical University, Lucknow, India. rsinghal23@hotmail.com
authors.forename: Rameshwari
authors.initials: R
authors.lastname: Singhal
authors.lastname: Nandlal
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Kumar
authors.forename: Pavitra
authors.initials: P
authors.lastname: Rastogi
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000601:surgery*; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D058752:Free Tissue Flaps; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008566:Membranes; D008875:Middle Aged; D010513:Periodontal Ligament / Q000502:physiology*; D010521:Periosteum / Q000637:transplantation*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite