title: [Anesthesia for a hemodialysis patient with HIT undergoing CABG using argatroban].
abstract: Anesthetic Management of CABG in a Hemodialysis patient complicated by heparin-induced thrombocytopenia (HIT) type II is one of the different procedures in hemodialysis patients using heparin. An 81-year-old man receiving hemodialysis complicated by HIT type II was scheduled for coronary artery bypass grafting (CABG). Anesthesia was induced and maintained with propofol, remifentanil and rocuronium. During artificial cardiopulmonary bypass, activated clotting time (ACT) was maintained above 300 sec by in initial 0.1 mg x kg(-1) and subsequent 2.0-7.0 microg x kg(-1) x min(-1) doses of argatroban; a direct thrombin inhibitor. Immediately after the completion of the external cardiopulmonary circulation, continuous infusion of argatroban was discontinued. Seven hours later ACT was restored to the preoperative level. Both intra and postoperative courses were uneventful.
authors.affiliation: Department of Anesthesia, Nagano Red Cross Hospital, Nagano 380-8582.
authors.forename: Shinya
authors.initials: S
authors.lastname: Goto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hiramori
authors.forename: Kaori
authors.initials: K
authors.lastname: Kuroiwa
authors.forename: Noriaki
authors.initials: N
authors.lastname: Mochizuki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D000369:Aged, 80 and over; D000768:Anesthesia, General / Q000379:methods*; D000925:Anticoagulants / Q000009:adverse effects*; D000991:Antithrombins / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D001026:Coronary Artery Bypass; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010875:Pipecolic Acids / Q000627:therapeutic use*; D006435:Renal Dialysis; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban