title: Self-assembled vesicles prepared from amphiphilic cyclodextrins as drug carriers.
abstract: Controlled self-assembly of amphiphilic cyclodextrin is always a challenging topic in the field of supramolecular chemistry, since it provides the spontaneous generation of well-defined aggregation with functional host sites with great potential applications in drug-carrier systems. β-Cyclodextrin modified with an anthraquinone moiety (1) was successfully synthesized. In the aqueous solution, 1 was found able to self-assemble into vesicles, which was characterized in detail by TEM, SEM, EFM, and DLS. The formation mechanism of the vesicles was suggested based on the 2D ROESY and UV-vis results, and further verified by the MD simulation. Subsequently, the stimuli response property of the vesicles, including to Cu(2+) and H(+), was also studied. The vesicles can efficiently load Paclitaxel inside the membrane with functional macrocyclic cavities available, which can further carry small molecules, such as ferrocene. The vesicles loading with Paclitaxel have remarkable anticancer effects. This work will provide new strategy in drug-carrier systems and tumor treatment methods.
authors.affiliation: School of Chemistry & Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Qie
authors.initials: Q
authors.lastname: Guo
authors.forename: Cai
authors.initials: C
authors.lastname: Zhang
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Hao
authors.forename: Pengyao
authors.initials: P
authors.lastname: Xing
authors.forename: Jie
authors.initials: J
authors.lastname: Su
authors.forename: Shangyang
authors.initials: S
authors.lastname: Li
authors.forename: Aiyou
authors.initials: A
authors.lastname: Hao
authors.forename: Guangcun
authors.initials: G
authors.lastname: Liu
mesh_terms: D000880:Anthraquinones / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005296:Ferrous Compounds / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000075163:Metallocenes; D046529:Microscopy, Electron, Transmission; D056004:Molecular Dynamics Simulation; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D012542:Scattering, Radiation; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D004337:Drug Carriers; D005296:Ferrous Compounds; D008051:Lipid Bilayers; D000075163:Metallocenes; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; D014867:Water; D017239:Paclitaxel; C004998:ferrocene