title: In vitro activity of linezolid against clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains from Beijing, China.
abstract: The in vitro activity of linezolid was evaluated against 84 clinical isolates of  Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant  (XDR) strains, isolated from the center for tuberculosis research and treatment of the Chinese  army. Linezolid showed excellent activity, with minimum inhibitory concentrations (MICs) of  0.125-0.5 μg/mL against all tested isolates. There were no differences in the MIC(50) and MIC(90)  of linezolid between susceptible, isoniazid-resistant, MDR, and XDR. Indeed, all of the groups  displayed identical MIC(90) values of 0.25 μg/mL, which is lower than previously reported in  similar studies. We conclude that linezolid may be a more effective drug against M. tuberculosis  and may play an important role in treating drug-resistant tuberculosis in China.
authors.affiliation: Department of Clinical Laboratory, 309th Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Caie
authors.initials: C
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Lei
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Xianghong
authors.initials: X
authors.lastname: Meng
authors.forename: Jufang
authors.initials: J
authors.lastname: He
authors.forename: Aihua
authors.initials: A
authors.lastname: Tong
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D054908:Extensively Drug-Resistant Tuberculosis / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification*; D023303:Oxazolidinones / Q000494:pharmacology*; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; D000069349:Linezolid