title: Serum concentrations of resistin and adiponectin and their relationship to insulin resistance in subjects with impaired glucose tolerance.
abstract: OBJECTIVE
  This study measured the serum concentrations of resistin and adiponectin in Chinese subjects with impaired glucose tolerance (IGT) and investigated their association with insulin resistance, metabolic parameters and circulating inflammatory markers.
  
  
  METHODS
  A total of 124  subjects participated in the study (44 with IGT and 80 with normal glucose tolerance [NGT]). Fasting serum concentrations of lipids, glucose, insulin and adipocytokines (resistin, adiponectin, leptin, tumour necrosis factor-α [TNF-α], interleukin-6 and C-reactive  protein) were measured.
  
  
  RESULTS
  Serum resistin concentrations were similar in the IGT and NGT groups but were significantly higher in overweight/ obese IGT subjects than in those of normal weight. Serum adiponectin concentrations were significantly lower in the IGT group than in the NGT group.  In the IGT group, resistin was positively correlated with age, body mass index and TNF-α, and adiponectin was correlated positively with high-density lipoprotein cholesterol and negatively with TNF-α and waist/hip ratio.
  
  
  CONCLUSIONS
  Circulating resistin is unlikely  to be a major mediator of glucose tolerance in humans but it may have an inflammatory role in IGT. The data support the theory that circulating adiponectin has an anti-inflammatory and anti-insulin resistance function.
authors.affiliation: Medical Scientific Research Centre, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: R
authors.initials: R
authors.lastname: Luo
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Jiang
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.forename: Z
authors.initials: Z
authors.lastname: Lü
authors.forename: W
authors.initials: W
authors.lastname: Hua
mesh_terms: D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D052243:Resistin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D005947:Glucose