title: Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits.
abstract: BACKGROUND
  Peridural fibrosis is an inevitable healing process causing failed back surgery syndrome after lumbar spinal operations. In this study, alpha-lipoic acid (ALA), reported to reduce fibrosis in liver, oral mucosa, and peritoneum, investigated as a potential candidate for prevention of peridural fibrosis.
  
  
  METHODS
  Twelve adult New Zealand white male rabbits were divided into control (n = 5) and ALA groups (n = 7). Laminectomy of lumbar spine was performed and ALA was applied on the exposed dura mater topically in ALA group.
  
  
  RESULTS
  According to histological peridural grading, the ALA group (median grade 1) showed significantly less peridural fibrosis than the control group (median grade 3, p = 0.005).
  
  
  CONCLUSIONS
  ALA is a promising substance in the prevention of peridural fibrosis, especially in early preoperative and postoperative period.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Kafkas University, Kars, Turkey, 36100.
authors.forename: Miktat
authors.initials: M
authors.lastname: Kaya
authors.forename: Can Hakan
authors.initials: CH
authors.lastname: Yildirim
authors.forename: Kemal
authors.initials: K
authors.lastname: Kosemehmetoglu
authors.forename: Urfettin
authors.initials: U
authors.lastname: Huseyinoglu
authors.forename: Hakan
authors.initials: H
authors.lastname: Erdogan
authors.forename: Aytac
authors.initials: A
authors.lastname: Akbasak
authors.forename: Erol
authors.initials: E
authors.lastname: Tasdemiroglu
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004388:Dura Mater / Q000187:drug effects* / Q000473:pathology*; D055111:Failed Back Surgery Syndrome / Q000473:pathology / Q000517:prevention & control; D005355:Fibrosis / Q000473:pathology; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000601:surgery*; D008297:Male; D011817:Rabbits; D008063:Thioctic Acid / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid