title: Adiponectin to leptin index as a marker of endometrial cancer in postmenopausal women with abnormal vaginal bleeding: an observational study.
abstract: OBJECTIVE
  To evaluate the correlation between endometrial cancer and adiponectin plasma concentration, leptin plasma concentration as well as adiponectin to leptin index in the population of postmenopausal women with abnormal vaginal bleeding.
  
  
  METHODS
  An observational study SETTINg: Department of Gynecology and Obstetrics, Specialist Teaching Hospital in Tychy, Poland. Population. 99 women between 47 and 88 years old, in postmenopausal state.
  
  
  METHODS
  The cases (54 women) were females hospitalized due to postmenopausal vaginal bleeding in whom dilation and curettage (D&C) was performed and endometrial intraepithelial neoplasia (EIN) was diagnosed in anathomopathology. Hysterectomy was then performed in all cases and the endometrial cancer diagnosis was confirmed. The controls (45 women) consists of females with no postmenopausal uterine bleeding in whom endometrial thickness in transvaginal ultrasound was greater than 5 mm. D&C was than performed and no endometrial neoplasia was detected in any of the subjects. Adiponectin and leptin plasma concentration was measured in both groups. Mein outcome measures. The area under the curve, sensitivity, specificity and cutoffs for adiponectin, leptin and adiponectin to leptin index.
  
  
  RESULTS
  Adiponectin, leptin and adiponectin to leptin index were statistically correlated with the risk of endometrial cancer. At the suggested cutoffs, corresponding to the highest accuracy (minimal false-negative and false-positive results), adiponectin to leptin index resulted in the highest sensitivity and specificity compared to adiponectin and leptin alone.
  
  
  CONCLUSIONS
  Adiponectin to leptin index due to the highest sensitivity and specificity may be used as a marker of endometrial cancer in postmenopausal women with abnormal vaginal bleeding.
authors.affiliation: Department of Gynecology and Obstetrics, Specialist Teaching Hospital in Tychy, Poland. krzysnowosilcow@yahoo.com
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Nowosielski
authors.forename: Janusz
authors.initials: J
authors.lastname: Pozowski
authors.forename: Izabela
authors.initials: I
authors.lastname: Ulman-Włodarz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Romanik
authors.forename: Ryszard
authors.initials: R
authors.lastname: Poręba
authors.forename: Urszula
authors.initials: U
authors.lastname: Sioma-Markowska
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014592:Uterine Hemorrhage / Q000097:blood* / Q000150:complications
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin