title: Simultaneous optically sectioned fluorescence and optical coherence microscopy                 with full-field illumination.
abstract: Full-field optical coherence microscopy (FF-OCM) and optically sectioned                 fluorescence microscopy are two imaging techniques that are implemented here in a                 novel dual modality instrument. The two imaging modalities use a broad field                 illumination to acquire the entire field of view without raster scanning. Optical                 sectioning is achieved in both imaging modalities owing to the coherence gating                 property of light for FF-OCM, and a structured illumination setup for fluorescence                 microscopy. Complementary image data are provided by the dual modality instrument in                 the context of biological tissue screening. FF-OCM imaging modality shows the tissue                 microarchitecture, while fluorescence microscopy highlights specific tissue features                 with cellular-level resolution by using targeting contrast agents. Complementary                 tissue morphology and biochemical features could potentially improve the                 understanding of cellular functions and disease diagnosis.
authors.affiliation: Laboratoire Charles Fabry, CNRS UMR 8501, Institut d’Optique Graduate School, University Paris-Sud, Palaiseau, France.
authors.forename: Houssine
authors.initials: H
authors.lastname: Makhlouf
authors.forename: Karen
authors.initials: K
authors.lastname: Perronet
authors.forename: Guillaume
authors.initials: G
authors.lastname: Dupuis
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lévêque-Fort
authors.forename: Arnaud
authors.initials: A
authors.lastname: Dubois
mesh_terms: D000818:Animals; D003106:Colon / Q000166:cytology; D008029:Lighting / Q000379:methods*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods*; D055620:Optical Phenomena; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*