title: Photodegradation of oxytocin and thermal stability of photoproducts.
abstract: Photodegradation of oxytocin at λ = 253.7 nm and λ ≥ 290 nm results in the transformation of the intrachain disulfide bond into predominantly dithiohemiacetal and thioether. Especially the dithiohemiacetal is sensitive to further degradation by light and/or elevated temperature, implying that the combination of an initial photostress and a subsequent heat stress can yield products significantly different compared with those observed under heat stress only.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Mozziconacci
authors.forename: Christian
authors.initials: C
authors.lastname: Schöneich
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004220:Disulfides / Q000737:chemistry / Q000528:radiation effects*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010120:Oxytocics / Q000737:chemistry / Q000528:radiation effects*; D010121:Oxytocin / Q000737:chemistry / Q000528:radiation effects*; D010782:Photolysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D053719:Tandem Mass Spectrometry; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D004220:Disulfides; D010120:Oxytocics; D010121:Oxytocin