title: Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats.
abstract: Peripheral neuropathy is one of the most frequent and severe complications of diabetes. Hydroxytyrosol (HT), the major antioxidant polyphenolic compound of olive oil, has been investigated as a new potential treatment to counteract the progression of peripheral diabetic neuropathy in rats. An established model of streptozotocin-induced diabetes has been used. After confirmation of hyperglycemia, diabetic and nondiabetic animals were randomized to receive either a low dose or a high dose of HT, or the corresponding vehicle, for 6 weeks. At the end of the 6-week period of treatment, HT blunted plasma thiobarbituric acid-reactive substances increase (p < 0.05) and significantly reduced nerve conduction velocity (p < 0.05) and thermal nociception impairment in diabetic rats (p < 0.05). Sciatic nerve Na(+), K(+)-ATPase activity reduction was also abolished by HT (p < 0.05). The present study provides evidence of the therapeutic potential of the natural substance hydroxytyrosol in the early stage of diabetic neuropathy.
authors.affiliation: Mario Negri Institute for Pharmacological Research, via La Masa 19, 20156 Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ristagno
authors.forename: Francesca
authors.initials: F
authors.lastname: Fumagalli
authors.forename: Carla
authors.initials: C
authors.lastname: Porretta-Serapiglia
authors.forename: Alessandro
authors.initials: A
authors.lastname: Orrù
authors.forename: Chiara
authors.initials: C
authors.lastname: Cassina
authors.forename: Marzia
authors.initials: M
authors.lastname: Pesaresi
authors.forename: Serge
authors.initials: S
authors.lastname: Masson
authors.forename: Luciano
authors.initials: L
authors.lastname: Villanova
authors.forename: Alessandro
authors.initials: A
authors.lastname: Merendino
authors.forename: Azzurra
authors.initials: A
authors.lastname: Villanova
authors.forename: Luigi
authors.initials: L
authors.lastname: Cervo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.forename: Roberto
authors.initials: R
authors.lastname: Latini
authors.forename: Roberto
authors.initials: R
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000150:complications / Q000188:drug therapy*; D008297:Male; D000069463:Olive Oil; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D000069463:Olive Oil; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol