title: Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats.
abstract: BACKGROUND
  The ethnopharmacological importance of Pithecellobium dulce is evidenced by its traditional use for gastric complications. The aim of the study is to evaluate the gastroprotective activity and the mechanism of action of hydroalcoholic fruit extract of P. dulce (HAEPD) in rats by using chemical and stress induced ulcer models.
  
  
  METHODS
  Gastric ulcer was induced by administering alcohol (or) acetylsalicylic acid (or) hypothermic restraint stress to rats pretreated with HAEPD (200 mg/kgbwt for 30 day). Volume of gastric fluid, pH, acidity, activities of pepsin, H(+), K(+)-ATPase, myeloperoxidase, mucin content, nucleic acids, glycoproteins and prostaglandin E(2) (PGE(2)) levels were assessed in gastric tissues.
  
  
  RESULTS
  Ulcer score was significantly minimized in HAEPD administered animals. pH and acidity of gastric fluid were significantly minimized and the mucin, PGE(2) levels were significantly maintained in drug pre administered animals. The activities of H(+), K(+)- ATPase and myeloperoxidase were found to be significantly elevated in ulcer control animals and found to be decreased in drug pretreated animals. The cell proliferation was found to be enhanced in drug received animals. The total protein bound carbohydrate to total protein ratio was found to be significantly maintained by HAEPD. The effects were found to be comparable with that of standard drug omeprazole.
  
  
  CONCLUSIONS
  It is concluded that HAEPD possess a potent antiulcer activity probably by acting as cytoprotective and antiacid secretory agent.
authors.affiliation: Research and Development Centre, Bharathiar University, Coimbatore 641046, India.
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Megala
authors.forename: Arumugam
authors.initials: A
authors.lastname: Geetha
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects; D050260:Carbohydrate Metabolism / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003080:Cold Temperature; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D007887:Fabaceae; D005638:Fruit; D005744:Gastric Acid / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D009077:Mucins / Q000378:metabolism; D009853:Omeprazole / Q000494:pharmacology; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D009077:Mucins; D010936:Plant Extracts; D011506:Proteins; D000431:Ethanol; D009195:Peroxidase; D017506:H(+)-K(+)-Exchanging ATPase; D015232:Dinoprostone; D009853:Omeprazole; D001241:Aspirin