title: Gastroprotective activity of Sterculia striata A. St. Hil. & Naudin (Malvaceae) in rodents.
abstract: The Sterculia striata ethanolic extract (Ss-EtOH) inhibited gastric lesions induced by ethanol, HCl/ethanol, and ischemia/reperfusion, but not those induced by indomethacin, and did not alter the gastric secretion. Ss-EtOH restored the catalase activity and content of nonprotein sulfhydryl groups in the stomach of mice treated with ethanol. The gastroprotection induced by Ss-EtOH in the ethanol-induced gastric lesion model was abolished by N(G)-nitroL-arginine methyl ester (L-NAME) pretreatment, suggesting the involvement of nitric oxide and antioxidant compounds, but not prostaglandins, in this activity. Lupeol obtained from Ss-EtOH promoted gastroprotection as well as the extract at the same dose, and it must therefore contribute to the observed effects.
authors.affiliation: Medicinal Plants Research Center, Federal University of Piauí, Av. Nossa Senhora de Fátima s/n, 64049-550 Teresina, PI, Brazil.
authors.forename: Joubert A
authors.initials: JA
authors.lastname: Sousa
authors.forename: Irisdalva S
authors.initials: IS
authors.lastname: Oliveira
authors.forename: Francilene V
authors.initials: FV
authors.lastname: Silva
authors.forename: Danielly A
authors.initials: DA
authors.lastname: Costa
authors.forename: Mariana H
authors.initials: MH
authors.lastname: Chaves
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Oliveira
authors.forename: Paulo H M
authors.initials: PH
authors.lastname: Nunes
authors.forename: Rita C M
authors.initials: RC
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005260:Female; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D032361:Sterculia / Q000737:chemistry*
chemical_list: D000897:Anti-Ulcer Agents