title: 41-Azido-41-de-oxy-rapamycin.
abstract: The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent-accessible voids.
authors.forename: Lijun
authors.initials: L
authors.lastname: Xie
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Zuo
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Yuanrong
authors.initials: Y
authors.lastname: Cheng