title: Halogenated spirotetronates from Actinoallomurus.
abstract: Two new members of the spirotetronate class, nai414-A and nai414-B, were discovered and isolated from an Actinoallomurus sp. Their structures were established by 1D and 2D NMR, UV, and MS analyses and by chemical degradation. They showed antimicrobial and antitumor activity against Gram-positive bacteria and against human microvascular endothelial cells, respectively. Substituting bromide for chloride ions in the growth medium afforded mono- and dibrominated derivatives.
authors.affiliation: NAICONS, Via G. Fantoli 16/15, 20138, Milan, Italy. dr.carlo.mazzetti@tiscali.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Mazzetti
authors.forename: Mirko
authors.initials: M
authors.lastname: Ornaghi
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaspari
authors.forename: Silvia
authors.initials: S
authors.lastname: Parapini
authors.forename: Sonia
authors.initials: S
authors.lastname: Maffioli
authors.forename: Margherita
authors.initials: M
authors.lastname: Sosio
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D006846:Hydrocarbons, Halogenated; D013141:Spiro Compounds; C574826:nai414-A; C574827:nai414-B