title: Serum interleukin-9 levels are associated with clinical severity in children with atopic dermatitis.
abstract: Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by impaired immune response. Th9 cells are a sub-population of T cells that release interleukin (IL)-9. No study has investigated the role of IL-9 in AD. This study compared 64 children with AD with 45 healthy children. Serum IL-9 levels were measured and clinical symptoms were assessed. Children with AD had higher serum IL-9 levels than controls (p = 0.01). Clinical severity was significantly related to IL-9 level, indicating that IL-9 might exert a pathogenic role in symptom occurrence in individuals with AD. Children with AD may have higher serum IL-9 levels than healthy children, and IL-9 levels are significantly related to symptom severity.
authors.affiliation: Istituto Di Ricovero e Cura a Carattere Scientifico-Azienda Ospedaliera Universitaria San Martino di Genova, Genoa, Italy. gio.cip@libero.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ciprandi
authors.forename: Mara
authors.initials: M
authors.lastname: De Amici
authors.forename: Vania
authors.initials: V
authors.lastname: Giunta
authors.forename: Alessia
authors.initials: A
authors.lastname: Marseglia
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Marseglia
mesh_terms: D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016906:Interleukin-9 / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index
chemical_list: D016906:Interleukin-9