title: Fat tissue histological study at indocyanine green-mediated photothermal/photodynamic treatment of the skin in vivo.
abstract: Histological slices of skin samples with the subcutaneous adipose tissue after photothermal/photodynamic treatment are analyzed. In the case of subcutaneous indocyanine green injection and 808-nm diode laser exposure of the rat skin site in vivo, the greatest changes in tissue condition were observed. Processes were characterized by dystrophy, necrosis, and desquamation of the epithelial cells, swelling and necrosis of the connective tissue, and widespread necrosis of the subcutaneous adipose tissue. The obtained data are useful for safe layer-by-layer dosimetry of laser illumination of ICG-stained adipose tissue for treatment of obesity and cellulite.
authors.affiliation: Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskay Str., 410012 Saratov, Russia. irina-yanina@list.ru
authors.forename: Irina Yu
authors.initials: IY
authors.lastname: Yanina
authors.forename: Valery V
authors.initials: VV
authors.lastname: Tuchin
authors.forename: Nikita A
authors.initials: NA
authors.lastname: Navolokin
authors.forename: Olga V
authors.initials: OV
authors.lastname: Matveeva
authors.forename: Alla B
authors.initials: AB
authors.lastname: Bucharskaya
authors.forename: Galina N
authors.initials: GN
authors.lastname: Maslyakova
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Altshuler
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006979:Hyperthermia, Induced; D007208:Indocyanine Green / Q000627:therapeutic use*; D007834:Lasers; D008066:Lipolysis / Q000187:drug effects*; D010778:Photochemotherapy; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*
chemical_list: D007208:Indocyanine Green