title: Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis.
abstract: Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltrating leukocytes and cytokine expression in susceptible SJL and resistant C57BL/6 mice during Theilervirus-induced acute polioencephalitis. In contrast to C57/BL6 mice, SJL mice show an increased number of Foxp3(+) regulatory T cells and CD45R(+) B cells associated with delayed viral elimination and elevated IL-10 mRNA transcripts in the brain. Results substantiate the hypothesis that an imbalanced cytokine milieu during the early infection phase contributes to ineffective antiviral immunity in animals with a susceptible genetic background.
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, Hannover, Germany.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Herder
authors.forename: Ingo
authors.initials: I
authors.lastname: Gerhauser
authors.forename: Stephanie Kristin
authors.initials: SK
authors.lastname: Klein
authors.forename: Pedro
authors.initials: P
authors.lastname: Almeida
authors.forename: Maren
authors.initials: M
authors.lastname: Kummerfeld
authors.forename: Reiner
authors.initials: R
authors.lastname: Ulrich
authors.forename: Frauke
authors.initials: F
authors.lastname: Seehusen
authors.forename: Karl
authors.initials: K
authors.lastname: Rohn
authors.forename: Dirk
authors.initials: D
authors.lastname: Schaudien
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumgärtner
authors.forename: Jochen
authors.initials: J
authors.lastname: Huehn
authors.forename: Andreas
authors.initials: A
authors.lastname: Beineke
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D018188:Cardiovirus Infections / Q000276:immunology* / Q000821:virology*; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000276:immunology; D005786:Gene Expression Regulation; D016130:Immunophenotyping; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics; D017493:Leukocyte Common Antigens / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000276:immunology / Q000821:virology; D012333:RNA, Messenger / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D017945:Theilovirus
chemical_list: D016207:Cytokines; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; C556062:IL10 protein, mouse; D012333:RNA, Messenger; D016753:Interleukin-10; D017493:Leukocyte Common Antigens