title: [Efficacy of enterocin S760 in treatment of mice with anthrax infection due to Bacillus anthracis M-71].
abstract: The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.
authors.forename: E A
authors.initials: EA
authors.lastname: Svetoch
authors.forename: A I
authors.initials: AI
authors.lastname: Borzilov
authors.forename: B V
authors.initials: BV
authors.lastname: Eruslanov
authors.forename: O V
authors.initials: OV
authors.lastname: Korobova
authors.forename: T I
authors.initials: TI
authors.lastname: Kombarova
authors.forename: V P
authors.initials: VP
authors.lastname: Levchuk
authors.forename: M G
authors.initials: MG
authors.lastname: Teĭmurazov
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Stepanshin
authors.forename: L I
authors.initials: LI
authors.lastname: Marinin
authors.forename: I A
authors.initials: IA
authors.lastname: Diatlov
mesh_terms: D000818:Animals; D000881:Anthrax / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D001408:Bacillus anthracis / Q000187:drug effects*; D001430:Bacteriocins / Q000008:administration & dosage* / Q000302:isolation & purification; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016984:Enterococcus faecium / Q000737:chemistry; D051379:Mice
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C554643:bacteriocin S760, Enterococcus faecium