title: Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging.
abstract: BACKGROUND
  Tinnitus is a poorly understood auditory perception of sound in the absence of external stimuli. Convergent evidence proposes that tinnitus perception involves brain structural alterations as part of its pathophysiology. The aim of this study is to investigate the structural brain changes that might be associated with tinnitus-related stress and negative emotions.
  
  
  METHODS
  Using high-resolution magnetic resonance imaging and diffusion tensor imaging, we investigated grey matter and white matter (WM) alterations by estimating cortical thickness measures, fractional anisotropy and mean diffusivity in 14 tinnitus subjects and 14 age- and sex-matched non-tinnitus subjects.
  
  
  RESULTS
  Significant cortical thickness reductions were found in the prefrontal cortex (PFC), temporal lobe and limbic system in tinnitus subjects compared to non-tinnitus subjects. Tinnitus sufferers were found to have disrupted WM integrity in tracts involving connectivity of the PFC, temporal lobe, thalamus and limbic system.
  
  
  CONCLUSIONS
  Our results suggest that such neural changes may represent neural origins for tinnitus or consequences of tinnitus and its associations.
authors.affiliation: Department of Medical Imaging, School of Health Sciences, The University of Liverpool, Thompson Yates Building, Liverpool, L69 3GB, UK. F.M.Aldhafeeri@liverpool.ac.uk
authors.forename: Faten M
authors.initials: FM
authors.lastname: Aldhafeeri
authors.forename: Ian
authors.initials: I
authors.lastname: Mackenzie
authors.forename: Tony
authors.initials: T
authors.lastname: Kay
authors.forename: Jamaan
authors.initials: J
authors.lastname: Alghamdi
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sluming
mesh_terms: D000328:Adult; D016880:Anisotropy; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000473:pathology*