title: Macrolide-resistant Bordetella pertussis infection in newborn girl, France.
abstract: A macrolide antimicrobial drug was administered to a newborn with cough. On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA sequencing and PCR-restriction fragment length polymorphism showed a 2047 A-to-G mutation in the 3 copies of the 23S rRNA gene. Monitoring for macrolide resistance is essential in infants <6 months of age.
authors.affiliation: Institut Pasteur, Paris, France
authors.forename: Sophie
authors.initials: S
authors.lastname: Guillot
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Descours
authors.forename: Yves
authors.initials: Y
authors.lastname: Gillet
authors.forename: Jérome
authors.initials: J
authors.lastname: Etienne
authors.forename: Daniel
authors.initials: D
authors.lastname: Floret
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use; D001886:Bordetella pertussis / Q000187:drug effects* / Q000235:genetics; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use; D004252:DNA Mutational Analysis; D024881:Drug Resistance, Bacterial; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D016896:Treatment Outcome; D014917:Whooping Cough / Q000175:diagnosis* / Q000628:therapy
chemical_list: D012338:RNA, Ribosomal, 23S; D017963:Azithromycin; D017291:Clarithromycin