title: A molecular network underlying spontaneous cAMP oscillation and synchronization in Dictyostelium.
abstract: We propose a molecular network, incorporating both adaptation and phosphorylation, to account for the spontaneous cAMP oscillation of Dictyostelium discoideum. We have modified the scheme previously proposed by Loomis and his collaborators so as to include adaptation by the cAMP receptor and such that extracellular cAMP is formed by the secreted intracellular cAMP instead of being directly produced by adenylyl cyclase. Furthermore, our scheme provides better robustness, and can be applied to spontaneous cAMP production by a cluster of cells.
authors.affiliation: Life Science Production Div., NOF Corporation, 5-10 Tokodai, Tsukuba 300-2635, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sakurai
authors.forename: Seido
authors.initials: S
authors.lastname: Nagano
mesh_terms: D000222:Adaptation, Physiological; D000242:Cyclic AMP / Q000378:metabolism*; D004023:Dictyostelium / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP