title: Mitotic and mitogenic Wnt signalling.
abstract: Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell proliferation by promoting G1 phase. In mitosis, components of the Wnt signalling cascade function directly in spindle formation. Moreover, Wnt signalling is strongly activated in mitosis, suggesting that 'mitotic Wnt signalling' plays an important role to orchestrate a cell division program. Here, we review the complex interplay between Wnt signalling and the cell cycle.
authors.affiliation: Division of Molecular Embryology, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany. niehrs@dkfz.de
authors.forename: Christof
authors.initials: C
authors.lastname: Niehrs
authors.forename: Sergio P
authors.initials: SP
authors.lastname: Acebron
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051153:Wnt Proteins