title: Endoplasmic reticulum stress and the on site function of resident PTP1B.
abstract: Growing evidence links the stress at the endoplasmic reticulum (ER) to pathologies such as diabetes mellitus, obesity, liver, heart, renal and neurodegenerative diseases, endothelial dysfunction, atherosclerosis, and cancer. Therefore, identification of molecular pathways beyond ER stress and their appropriate modulation might alleviate the stress, and direct toward novel tools to fight this disturbance. An interesting resident of the ER membrane is protein tyrosine phosphatase 1B (PTP1B), an enzyme that negatively regulates insulin and leptin signaling, contributing to insulin and leptin resistance. Recently, new functions of PTP1B have been established linked to ER stress response. This review evaluates the novel data on ER stressors, discusses the mechanisms beyond PTP1B function in the ER stress response, and emphasizes the potential therapeutic exploitation of PTP1B to relieve ER stress.
authors.affiliation: Institute of Cellular Biology and Pathology N. Simionescu of the Romanian Academy 8, B.P. Hasdeu Street, Bucharest 050568, Romania. doina.popov@icbp.ro
authors.forename: Doina
authors.initials: D
authors.lastname: Popov
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D050171:Dyslipidemias / Q000188:drug therapy / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000502:physiology*; D005234:Fatty Liver / Q000188:drug therapy / Q000378:metabolism; D006331:Heart Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000502:physiology; D007674:Kidney Diseases / Q000188:drug therapy / Q000378:metabolism; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics / Q000502:physiology*
chemical_list: D007328:Insulin; D020738:Leptin; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1