title: Epigenetic modulation by TFII-I during embryonic stem cell differentiation.
abstract: TFII-I transcription factors play an essential role during early vertebrate embryogenesis. Genome-wide mapping studies by ChIP-seq and ChIP-chip revealed that TFII-I primes multiple genomic loci in mouse embryonic stem cells and embryonic tissues. Moreover, many TFII-I-bound regions co-localize with H3K4me3/K27me3 bivalent chromatin within the promoters of lineage-specific genes. This minireview provides a summary of current knowledge regarding the function of TFII-I in epigenetic control of stem cell differentiation.
authors.affiliation: Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut, Farmington, CT 06030, USA. dashzeveg@uchc.edu
authors.forename: Dashzeveg
authors.initials: D
authors.lastname: Bayarsaihan
authors.forename: Aleksandr V
authors.initials: AV
authors.lastname: Makeyev
authors.forename: Badam
authors.initials: B
authors.lastname: Enkhmandakh
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D047108:Embryonic Development; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000235:genetics / Q000378:metabolism; D051379:Mice; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D019473:Transcription Factors, TFII / Q000235:genetics / Q000378:metabolism*
chemical_list: D002843:Chromatin; C486330:Gtf2i protein, mouse; D006657:Histones; D019473:Transcription Factors, TFII