title: A microfluidic-based frequency-multiplexing impedance sensor (FMIS).
abstract: We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each 'sub-sensor' possesses its corresponding measurement frequency where the sample-specific dielectric properties can be probed. We have shown the validity of our frequency-multiplexing impedance sensor (FMIS) by comparison with conventional 'single sensors'. Our highly sensitive FMIS was proven suitable for life science applications through usage as a cell-based toxicology platform. We are confident that our technology might find great utility in parallelized cell-based analysis systems as well as in biomedical devices where size limitations and spatially distributed probing are important parameters.
authors.affiliation: Laboratoire de Microsystèmes LMIS4, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. robert.meissner@epfl.ch
authors.forename: Robert
authors.initials: R
authors.lastname: Meissner
authors.forename: Pierre
authors.initials: P
authors.lastname: Joris
authors.forename: Bilge
authors.initials: B
authors.lastname: Eker
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bertsch
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D015374:Biosensing Techniques / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000295:instrumentation; D017097:Electric Impedance; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin