title: Acute exercise adjustments of cardiovascular autonomic control in diabetic rats.
abstract: BACKGROUND
  We evaluated the role of cardiovascular autonomic changes in hemodynamics at rest and in response to exercise in streptozotocin-induced diabetic rats.
  
  
  METHODS
  Male Wistar rats were divided into nondiabetic (ND, n = 8) and diabetic (D, n = 8) groups. Arterial pressure signals were recorded in the basal state and after atropine or propranolol injections at rest, during exercise and during recovery.
  
  
  RESULTS
  At rest, vagal tonus was reduced in D (37 ± 3 bpm) in comparison with the ND group (61 ± 9 bpm). Heart rate during exercise was lower in D in relation to ND rats associated with reduced vagal withdrawal in the D group. The D rats had an increase in vagal tonus in the recovery period (49 ± 6 bpm).
  
  
  CONCLUSIONS
  Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics.
authors.affiliation: Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil.
authors.forename: Demilto Yamagushi
authors.initials: DY
authors.lastname: Da Pureza
authors.forename: Luciana
authors.initials: L
authors.lastname: Jorge
authors.forename: Iris Callado
authors.initials: IC
authors.lastname: Sanches
authors.forename: Maria-Cláudia
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Romeu Rodrigues
authors.initials: RR
authors.lastname: De Souza
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D001285:Atropine; D011433:Propranolol