title: Ultra wide field fluorescein angiography can detect macular pathology in central retinal vein occlusion.
abstract: The purpose of this study was to evaluate whether ultra wide field fluorescein angiography (UWFFA), a tool established for the detection of peripheral non-perfusion, can also detect macular pathology. A retrospective imaging review was performed on patients with central retinal vein occlusion. UWFFA was graded for angiographic leakage (petalloid and/or diffuse leakage) and presence of abnormalities in the foveal avascular zone and was then correlated to spectral-domain optical coherence tomography (SD-OCT). Sixty-six eyes met inclusion criteria. Intergrader agreement was highly reliable for grading macular leakage on UWFFA (kappa = 0.75) and moderately reliable for the evaluation of an abnormal foveal avascular zone (kappa = 0.43). Angiographic leakage on UWFFA correlated to macular edema on SD-OCT (P > .0001), and abnormalities in the foveal avascular zone on UWFFA correlated to ganglion cell layer atrophy on SD-OCT (P = .0002). Intergrader reliability in grading UWFFA was better when assessing macular leakage than when assessing macular ischemia. UWFFA findings correlated to macular edema and signs of macular ischemia on SD-OCT.
authors.affiliation: Retina Division, Department of Ophthalmology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. irena.tsui@gmail.com
authors.forename: Irena
authors.initials: I
authors.lastname: Tsui
authors.forename: Valentina
authors.initials: V
authors.lastname: Franco-Cardenas
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hubschman
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Steven D
authors.initials: SD
authors.lastname: Schwartz
mesh_terms: D002199:Capillary Permeability; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis*; D008269:Macular Edema / Q000175:diagnosis*; D015203:Reproducibility of Results; D012169:Retinal Vein / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence