title: No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia.
abstract: BACKGROUND
  The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia.
  
  
  METHODS
  Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia.
  
  
  RESULTS
  Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype.
  
  
  CONCLUSIONS
  The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.
authors.affiliation: Mental Health Research Institute SB RAMSci, Tomsk, Russian Federation.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Ivanova
authors.forename: Asmar F Y
authors.initials: AF
authors.lastname: Al Hadithy
authors.forename: Natalia
authors.initials: N
authors.lastname: Brazovskaya
authors.forename: Arkadiy
authors.initials: A
authors.lastname: Semke
authors.forename: Bob
authors.initials: B
authors.lastname: Wilffert
authors.forename: Olga
authors.initials: O
authors.lastname: Fedorenko
authors.forename: Jacobus R B J
authors.initials: JR
authors.lastname: Brouwers
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: Loonen
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007297:Inpatients; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy; D012800:Siberia / Q000453:epidemiology / Q000208:ethnology
chemical_list: D014150:Antipsychotic Agents; D043705:Receptor, Adenosine A2A; D017448:Receptors, Dopamine D2