title: Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation.
abstract: Pyoderma gangrenosum (PG) commonly occurs in association with various haematological and inflammatory disorders. We report a new association, a Janus kinase (JAK)2 mutation, in a 63-year-old patient with PG. We hypothesise that PG occurs by direct activation of JAK along with signal transducers and activators of transcription (STAT), a common mechanism involved in the pathogenesis of inflammatory and haematological diseases.
authors.affiliation: Department of Dermatology, Norfolk and Norwich University Hospital and NHS Trust, UK. drjananiap@gmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Palanivel
authors.forename: A E
authors.initials: AE
authors.lastname: Macbeth
authors.forename: N J
authors.initials: NJ
authors.lastname: Levell
mesh_terms: D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D007866:Leg; D008297:Male; D008875:Middle Aged; D009154:Mutation; D017511:Pyoderma Gangrenosum / Q000235:genetics*
chemical_list: D053614:Janus Kinase 2