title: Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer.
abstract: We studied the contribution of the IL12A 3'UTR G>A (rs568408) and IL12B 3'UTR A>C (rs3212227) polymorphisms to the risk of cervical cancer. These polymorphisms were genotyped in four hundred-five patients with cervical cancer and four hundred fifty unrelated healthy females from the Polish population. Logistic regression analysis adjusting for age, pregnancy, oral contraceptive use, tobacco smoking, and menopausal status revealed that the IL12B 3'UTR A>C polymorphism could be a genetic risk factor for cervical cancer. The adjusted odds ratio (OR) for patients with the A/C genotype vs A/A genotype was 1.557 (95 % CI = 1.173-2.066, p = 0.0178) and adjusted OR for the C/C or A/C genotype vs the A/A genotype was 1.635 (95 % CI = 1.241-2.153, p = 0.0125). However, logistic regression analysis did not show an association of the IL12A 3'UTR G>A polymorphism with cervical cancer development in the studied Polish population. Our studies confirmed that the IL12B 3'UTR A>C polymorphism may be a genetic risk factor for cervical cancer.
authors.affiliation: Department of Radiotherapy and Gynecological Oncology, Greater Poland Cancer Centre Poznan, Poznań, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Roszak
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.forename: Anna
authors.initials: A
authors.lastname: Sowińska
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.forename: Pawel P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053765:Interleukin-12 Subunit p35 / Q000235:genetics*; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology
chemical_list: C508858:IL12A protein, human; C500879:IL12B protein, human; D053765:Interleukin-12 Subunit p35; D053762:Interleukin-12 Subunit p40