title: Role of host reticulon proteins in rearranging membranes for positive-strand RNA virus replication.
abstract: Positive-strand RNA [(+)RNA] viruses are responsible for numerous human, animal, and plant diseases. Because of the limiting coding capacity of (+)RNA viruses, their replication requires a complex orchestration of interactions between the viral genome, viral proteins and exploited host factors. To replicate their genomic RNAs, (+)RNA viruses induce membrane rearrangements that create membrane-linked RNA replication compartments. Along with substantial advances on the ultrastructure of the membrane-bound RNA replication compartments, recent results have shed light into the role that host factors play in rearranging these membranes. This review focuses on recent insights that have driven a new understanding of the role that the membrane-shaping host reticulon homology domain proteins (RHPs) play in facilitating the replication of various (+)RNA viruses.
authors.affiliation: Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, United States.
authors.forename: Arturo
authors.initials: A
authors.lastname: Diaz
authors.forename: Paul
authors.initials: P
authors.lastname: Ahlquist
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000648:ultrastructure; D016679:Genome, Viral; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry / Q000648:ultrastructure*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D012328:RNA Viruses / Q000235:genetics / Q000502:physiology*; D012367:RNA, Viral / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
chemical_list: D008565:Membrane Proteins; D012367:RNA, Viral; D014764:Viral Proteins