title: Comparison of anterior chamber depth measurements by 3-dimensional optical coherence tomography, partial coherence interferometry biometry, Scheimpflug rotating camera imaging, and ultrasound biomicroscopy.
abstract: OBJECTIVE
  To evaluate the congruity of anterior chamber depth (ACD) measurements using 4 devices.
  
  
  METHODS
  Saneikai Tsukazaki Hospital, Himeji City, Japan.
  
  
  METHODS
  Comparative case series.
  
  
  METHODS
  In 1 eye of 42 healthy participants, the ACD was measured by 3-dimensional corneal and anterior segment optical coherence tomography (CAS-OCT), partial coherence interferometry (PCI), Scheimpflug imaging, and ultrasound biomicroscopy (UBM). The differences between the measurements were evaluated by 2-way analysis of variance and post hoc analysis. Agreement between the measurements was evaluated using Bland-Altman analysis. To evaluate the true ACD using PCI, the automatically calculated ACD minus the central corneal thickness measured by CAS-OCT was defined as PCI true. Two ACD measurements were also taken with CAS-OCT.
  
  
  RESULTS
  The mean ACD was 3.72 mm ± 0.23 (SD) (PCI), 3.18 ± 0.23 mm (PCI true), 3.24 ± 0.25 mm (Scheimpflug), 3.03 ± 0.25 mm (UBM), 3.14 ± 0.24 mm (CAS-OCT auto), and 3.12 ± 0.24 mm (CAS-OCT manual). A significant difference was observed between PCI biometry, Scheimpflug imaging, and UBM measurements and the other methods. Post hoc analysis showed no significant differences between PCI true and CAS-OCT auto or between CAS-OCT auto and CAS-OCT manual. Strong correlations were observed between all measurements; however, Bland-Altman analysis showed good agreement only between PCI true and Scheimpflug imaging and between CAS-OCT auto and CAS OCT manual.
  
  
  CONCLUSIONS
  The ACD measurements obtained from PCI biometry, Scheimpflug imaging, CAS-OCT, and UBM were significantly different and not interchangeable except for PCI true and CAS-OCT auto and CAS-OCT auto and CAS-OCT manual.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nakakura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Mori
authors.forename: Nozomi
authors.initials: N
authors.lastname: Nagatomi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tabuchi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiuchi
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000033:anatomy & histology*; D001699:Biometry; D003315:Cornea / Q000033:anatomy & histology; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007368:Interferometry / Q000295:instrumentation; D008297:Male; D033401:Microscopy, Acoustic / Q000295:instrumentation; D008875:Middle Aged; D010781:Photography / Q000295:instrumentation; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence / Q000295:instrumentation; D055815:Young Adult