title: Hortonones A to C, hydroazulenones from the genus Hortonia.
abstract: The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton, and hortonone C (3) has the unprecedented rearranged and degraded 13-norhortonane skeleton. Hortonone C (3) exhibited in vitro cytotoxicity against human breast cancer MCF-7 cells at 5 μg/mL.
authors.affiliation: Department of Chemistry and Earth, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Gavin
authors.initials: G
authors.lastname: Carr
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Rukmal
authors.initials: R
authors.lastname: Ratnayake
authors.forename: Ratnayake
authors.initials: R
authors.lastname: Bandara
authors.forename: Siril
authors.initials: S
authors.lastname: Wijesundara
authors.forename: Tamsin
authors.initials: T
authors.lastname: Tarling
authors.forename: Aruna D
authors.initials: AD
authors.lastname: Balgi
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
authors.forename: Veranja
authors.initials: V
authors.lastname: Karunaratne
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D029585:Monimiaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013188:Sri Lanka
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C574878:hortonone A; C574880:hortonone B; C574879:hortonone C