title: Treatment strategies for well-differentiated liposarcomas and therapeutic outcomes.
abstract: This study examined 45 patients with well-differentiated liposarcoma who were surgically treated at our hospital (initial surgery in 41 patients and reoperation in 4). Only one patient had recurrence among patients who underwent initial surgery, and the recurrence was localised in the retroperitoneal space. For patients who underwent reoperation, the mean time between the initial surgery and the recurrence was 16.5 years. None of the 45 patients developed distant metastasis. It is important to preserve not only neurovascular bundles but also lower limb muscles in order to maintain ambulatory ability in the elderly patients. For well-differentiated liposarcomas of the limbs, it is important to establish a surgical margin beyond the marginal resection border and to perform muscle resection to the extent that would not greatly reduce the muscle strength.
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641 Japan. norinori@med.kanazawa-u.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Tanzawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kimura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Igarashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inatani
authors.forename: Shingo
authors.initials: S
authors.lastname: Shimozaki
authors.forename: Seiko
authors.initials: S
authors.lastname: Kitamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuchiya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054337:Cell Dedifferentiation; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000473:pathology / Q000601:surgery*; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D016896:Treatment Outcome