title: Comparison of hippocampal volume measured using magnetic resonance imaging in Alzheimer's disease, vascular dementia, mild cognitive impairment and pseudodementia.
abstract: OBJECTIVE
  To examine the relationship between different types of dementia and hippocampal volume.
  
  
  METHODS
  Hippocampal volume was measured by magnetic resonance imaging in patients with Alzheimer's disease (n = 22), vascular dementia (n = 14), mild cognitive impairment  (n = 12) or pseudodementia (n = 16), and in healthy control subjects (n = 11). The Mini Mental State Examination was used to stratify subjects according to cognitive function.
  
  
  RESULTS
  Hippocampal volume was reduced by 42% in Alzheimer's disease, 21% in vascular dementia,  15% in mild cognitive impairment and 13% in pseudodementia compared with controls. The severity of dementia increased in line with decreasing hippocampal volume.
  
  
  CONCLUSIONS
  Measurement of hippocampal volume may facilitate differentiation between dementia subtypes. There was a relationship  between reduced hippocampal volume and the degree of cognitive impairment.
authors.affiliation: Department of Radiology, Eskisehir Gynaecology Obstetrics Paediatrics Hospital, Eskisehir, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Dolek
authors.forename: S
authors.initials: S
authors.lastname: Saylisoy
authors.forename: D
authors.initials: D
authors.lastname: Ozbabalik
authors.forename: B
authors.initials: B
authors.lastname: Adapinar
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology*; D015140:Dementia, Vascular / Q000473:pathology*; D005162:Factitious Disorders / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D011581:Psychological Tests