title: Early repair of open abdomen with a tailored two-component mesh and conditioning vacuum packing: a safe alternative to the planned giant ventral hernia.
abstract: OBJECTIVE
  Once open abdomen therapy has succeeded, the problem of closing the abdominal wall must be addressed. We present a new four-stage procedure involving the application of a two-component mesh and vacuum conditioning for abdominal wall closure of even large defects. The aim is to prevent the development of a giant ventral hernia and the eventual need for the repair of the abdominal wall.
  
  
  METHODS
  Nineteen of 62 patients treated by open abdomen over a two-year period could not receive primary abdominal wall closure. To achieve closure in these patients, we applied the following four-stage procedure: stage 1: abdominal damage control and conditioning of the abdominal wall; stage 2: attachment of a tailored two-component mesh of polyglycolic acid (PGA) and large pore polypropylene (PP) in intraperitoneal position (IPOM) plus placement of a vacuum bandage; stage 3: vacuum therapy for 3-4 weeks to allow granulation of the mesh and optimization of dermatotraction; stage 4: final skin suture. During stage 3, eligible patients were weaned from respirator and mobilized.
  
  
  RESULTS
  The abdominal wall gap in the 19 patients ranged in size from 240 cm(2) to more than 900 cm(2). An average of 3.44 vacuum dressing changes over 19 days were required to achieve 60-100 % granulation of the surface area, so final skin suture could be made. Already in stage 3, 14 patients (73.68 %) could be weaned from respirator an average of 6.78 days after placement of the two-component mesh; 6 patients (31.57 %) could be mobilized on the edge of the bed and/or to a bedside chair after an average of 13 days. No mesh-related hematomas, seromas, or intestinal fistulas were observed.
  
  
  CONCLUSIONS
  The four-stage procedure presented here is a viable option for achieving abdominal wall closure in patients treated with open abdomen, enabling us to avoid the development of planned giant ventral hernias. It has few complications and has the special advantage of allowing mobilization of the patients before final skin closure. Long-term course in a large number of patients must still confirm this result.
authors.affiliation: Department of General, Gastrointestinal, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Strasse 6, 97080, Wuerzburg, Germany. dietz_u@chirurgie.uni-wuerzburg.de
authors.forename: U A
authors.initials: UA
authors.lastname: Dietz
authors.forename: C
authors.initials: C
authors.lastname: Wichelmann
authors.forename: C
authors.initials: C
authors.lastname: Wunder
authors.forename: J
authors.initials: J
authors.lastname: Kauczok
authors.forename: L
authors.initials: L
authors.lastname: Spor
authors.forename: A
authors.initials: A
authors.lastname: Strauß
authors.forename: R
authors.initials: R
authors.lastname: Wildenauer
authors.forename: C
authors.initials: C
authors.lastname: Jurowich
authors.forename: C T
authors.initials: CT
authors.lastname: Germer
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000368:Aged; D005260:Female; D006555:Hernia, Ventral / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D019919:Prosthesis Implantation; D013526:Surgical Mesh; D014947:Wounds and Injuries / Q000209:etiology / Q000601:surgery*