title: Advanced epithelioid malignant peripheral nerve sheath tumor showing complete response to combined surgery and chemotherapy: a case report.
abstract: Malignant peripheral nerve sheath tumor (MPNST) is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addressed clinicopathological features rather than therapeutic procedures or clinical courses. We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Minagawa
authors.forename: Ryuta
authors.initials: R
authors.lastname: Shioya
authors.forename: Chigusa
authors.initials: C
authors.lastname: Sato
authors.forename: Ryuji
authors.initials: R
authors.lastname: Shichinohe
authors.forename: Go
authors.initials: G
authors.lastname: Yasui
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takahashi