title: Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum.
abstract: Two C(18)-diterpenoid alkaloids, puberunine (1) and puberudine (2), together with four other new alkaloids, including the first examples having β-oriented substitution at C-3 and a rare chloro-substituent were isolated from Aconitum barbatum var. puberulum. Their structures were elucidated by spectroscopic methods. Puberunine and puberudine, which possess a unique rearranged E ring and an opened A ring, respectively, represent new subtypes of the C(18)-diterpenoid alkaloids. A plausible biosynthetic pathway of 1 and 2 was proposed.
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
authors.forename: Zhen-Qiang
authors.initials: ZQ
authors.lastname: Mu
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Huang
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Feng
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000470:Alkaloids; D004224:Diterpenes; C574601:puberudine; C574600:puberunine