title: Pausing on the path to robustness.
abstract: Heat-shock proteins (Hsps) maintain homeostasis by assisting protein folding, and the transcriptional regulation of Hsp-coding genes has long been under study. Sawarkar et al. (2012) now report in Cell that Hsp90 is itself a transcriptional regulator required for RNA polymerase pausing, contributing to rapid, robust induction of many genes.
authors.affiliation: Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. mark.siegal@nyu.edu
authors.forename: Mark L
authors.initials: ML
authors.lastname: Siegal
authors.forename: Christine
authors.initials: C
authors.lastname: Rushlow