title: Cell surface expression of CD25 antigen (surface IL-2 receptor α-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients.
abstract: Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p = 0.04), expression of CD38 antigen (p = 0.001), and FMC-7 (p = 0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.
authors.affiliation: Kaplan Medical Center, Rehovot, affiliated with Hadassah and Hebrew University Medical School, Jerusalem, Israel, levsh@clalit.org.il.
authors.forename: Lev
authors.initials: L
authors.lastname: Shvidel
authors.forename: Andrei
authors.initials: A
authors.lastname: Braester
authors.forename: Osnat
authors.initials: O
authors.lastname: Bairey
authors.forename: Naomi
authors.initials: N
authors.lastname: Rahimi-Levene
authors.forename: Yair
authors.initials: Y
authors.lastname: Herishanu
authors.forename: Tamar
authors.initials: T
authors.lastname: Tadmor
authors.forename: Abraham
authors.initials: A
authors.lastname: Klepfish
authors.forename: Rosa
authors.initials: R
authors.lastname: Ruchlemer
authors.forename: Mordechai
authors.initials: M
authors.lastname: Shtalrid
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Aaron
authors.initials: A
authors.lastname: Polliack
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000096:biosynthesis; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000096:biosynthesis*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends
chemical_list: D000954:Antigens, Surface; D015415:Biomarkers; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit