title: Worsening renal function and prognosis in pulmonary hypertension patients hospitalized for right heart failure.
abstract: Increased central venous pressures have been associated with the development of worsening renal function (WRF), an important marker of prognosis. We sought to determine the incidence and prognostic significance of WRF in pulmonary hypertension patients (PH) with isolated right HF. A prospective study of PH clinic patients admitted to hospital for right HF. WRF was defined as a rise in creatinine of 26 μmol/L (0.3 mg/dL) within the first 48 hours of admission. A total of 32 patients were enrolled in this study, 67% of patients had moderate-severe chronic kidney disease with an eGFR ≤ 60 mL/min and 34% (n=11) developed WRF during their admission. The mean right atrial pressure was higher in patients with WRF (19 ± 7 mm Hg vs 12 ± 6 mm Hg, P=.05). A total of 36% of patients with WRF died in hospital compared to 5% in the group that did not develop WRF (OR for hospital death 13.3 ± 16, P=.03). The combined endpoint of death or readmission at 6 months was 45% in the WRF group and 43% in the group without WRF (P=.89). Significant renal dysfunction is common in patients with PH and an acute decline in renal function is an important marker of in hospital death and short term mortality in right heart failure.
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada. lmielniczuk@ottawaheart.ca
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Mielniczuk
authors.forename: George
authors.initials: G
authors.lastname: Chandy
authors.forename: Duncan
authors.initials: D
authors.lastname: Stewart
authors.forename: Vladamir
authors.initials: V
authors.lastname: Contreras-Dominguez
authors.forename: Haissam
authors.initials: H
authors.lastname: Haddad
authors.forename: C
authors.initials: C
authors.lastname: Pugliese
authors.forename: Ross A
authors.initials: RA
authors.lastname: Davies
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis*
chemical_list: D003404:Creatinine