title: Doubly biomimetic catecholic phosphorylcholine copolymer: a platform strategy for fabricating antifouling surfaces.
abstract: A doubly biomimetic PMNC polymer bearing cell antifouling phosphorylcholine and mussel adhesive protein catechol groups is synthesized. The polymer can be deposited onto a variety of substrates by dip-coating in an aqueous solution, adhering to surfaces via the catechol functional group while at the same time forming a cell outer membrane mimetic antifouling surface. Contact angle, ATR-FTIR and XPS measurements confirm polymer coating formation on a variety of inorganic and organic substrates. BSA and bovine plasma fibrinogen protein adsorption on PMNC coated surfaces are reduced significantly compared to unmodified substrates, and platelet adhesion from human serum onto the PMNC coated substrate surfaces is highly suppressed in this study.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China. gongyk@nwu.edu.cn
authors.forename: Yong-Kuan
authors.initials: YK
authors.lastname: Gong
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Liu
authors.forename: Phillip B
authors.initials: PB
authors.lastname: Messersmith
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D002396:Catechols / Q000737:chemistry*; D002417:Cattle; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis* / Q000494:pharmacology; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D010767:Phosphorylcholine / Q000737:chemistry*; D010973:Platelet Adhesiveness / Q000187:drug effects; D058105:Polymerization; D011506:Proteins / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D002396:Catechols; D020099:Coated Materials, Biocompatible; D004202:Disinfectants; D011506:Proteins; C037403:adhesive protein, mussel; D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D005340:Fibrinogen