title: [Design of a polymer drug for serological diagnosis of hepatitis C].
abstract: A new immunobiological polymer drug has been designed for the serological identification of hepatitis C. The drug is able to reveal specific antibodies in the sera of patients with hepatitis C, meets the current requirements of diagnostic test systems, and shows a high sensitivity and specificity. It is based on polyacroleinic microspheres; the concentrated cell culture biomass of hepatitis C virus (HCV), which contains an adequate set of viral antigens, is used as sensitin. A new diagnosticum is proposed to be used during primary (screening) laboratory studies based on the serological detection of total antibodies to HCV antigens in the volume agglomeration test. The latter is both one of the alternative methods during serological studies and an additional procedure when a set of diagnostic techniques is used.
authors.forename: L M
authors.initials: LM
authors.lastname: Verkina
authors.forename: N R
authors.initials: NR
authors.lastname: Telesmanich
authors.forename: D B
authors.initials: DB
authors.lastname: Mishin
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Lomov
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: A N
authors.initials: AN
authors.lastname: Terent'ev
authors.forename: I R
authors.initials: IR
authors.lastname: Siminova
authors.forename: A N
authors.initials: AN
authors.lastname: Narkevich
authors.forename: E A
authors.initials: EA
authors.lastname: Berezniak
mesh_terms: D000171:Acrolein / Q000737:chemistry / Q000276:immunology; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification*; D006526:Hepatitis C / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D006801:Humans; D007163:Immunosorbent Techniques; D007202:Indicators and Reagents / Q000737:chemistry; D008863:Microspheres; D011108:Polymers / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D007202:Indicators and Reagents; D011108:Polymers; C029975:polyacrolein; D000171:Acrolein