title: The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients.
abstract: BACKGROUND
  Fibroblast growth factor receptor 4 (FGFR4) was seldom investigated in gastric cancer (GC). The purpose of the study was to elucidate the expression of FGFR4 protein in GC and related clinical significance.
  
  
  METHODS
  Ninety-four paraffin-embedded tumor specimens were obtained from Cancer Hospital, Fudan University. The expression of FGFR4 as well as p53, p21, EGFR, neu, c-myc, and PCNA were detected by immunohistochemical method. Then, correlation analysis and survival analysis were performed.
  
  
  RESULTS
  The expression rate of FGFR4 protein in GC tissues and normal stomach tissues was 93.6% and 30.8%, respectively (P = 0.000). The expression of FGFR4 was positively correlated with the expression of p21, neu and PCNA (P-value was 0.009, 0.012, and 0.018, respectively). Subgroup analysis showed that compared to low expression group, the prognosis of patients with III/IV stage and negative expression of p21 in high expression group of FGFR4 were worse (P = 0.048, 0.041, respectively). Multivariate analysis showed that TNM stage was the independent prognostic factor in high expression group (HR, 11.593; 95% CI, 3.532-18.058; P = 0.000).
  
  
  CONCLUSIONS
  High expression of FGFR4 protein, accelerating the progression of advanced GC, might be associated with a poor prognosis in patients with advanced FC.
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China. yeyanwei66@163.com
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Ye
authors.forename: Xiefu
authors.initials: X
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jianghong
authors.initials: J
authors.lastname: Wu
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Guojun
authors.initials: G
authors.lastname: Wang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Du
authors.forename: Chunmeng
authors.initials: C
authors.lastname: Wang
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D051499:Receptor, Fibroblast Growth Factor, Type 4