title: [Study on the ReHo in treatment-naïve of temporal lobe epilepsy patients with depressive symptoms using resting functional-MRI (fMRI)].
abstract: Epilepsy is a common neurological disease accompanied with laden economic burdens and heavy social resources consuming. Temporal lobe epilepsy (TLE) is an important subtype of the epilepsies. Our experiment was aimed to characterize the regional brain function alteration among the treatment na? ve TLE patients using ReHo. We found that elevated regional ReHo was in the left insula in the TLE patients, and the right one was cingulated, while the decreasing ReHo was in right putamen. Our result demonstrated that the key components associated with the epilepsy symptoms had altered the regional function in the TLE patients, and the disruption of cortex-thalamus-striatum loop. Our experiment provides evidence on the pathophysiological alteration in treatment na? ve TLE patients.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, West China MR Research Centre, Chengdu 610041, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Zhong
authors.forename: Sihan
authors.initials: S
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Ouyang
authors.forename: Dongmei
authors.initials: D
authors.lastname: An
authors.forename: Su
authors.initials: S
authors.lastname: Lu
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D003863:Depression / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted