title: [Effects of cancer treatments on gonads].
abstract: High dose cytotoxic drug combinations as well as radiotherapies to the whole body, the pelvic region and the head ovarian are associated with a risk of gonadal damage. In men, cells responsible for sperm production are most prone to damage, but testosterone production is usually preserved. In women, cancer treatments are known to accelerate the disappearance of primordial follicles, prevent ovarian follicle growth and increase fibrosis. This decreases the non-regenerable pool of oocytes. In young women, the ovaries may function well shortly after cancer treatments, whereby getting pregnant is possible. However they are in inreased risk of premature menopause.
authors.affiliation: HUS, lasten ja nuorten sairaala, Astrid Lindgrenin lastensairaala, lasten endokrinologian laboratorio, Tukholma.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Jahnukainen
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006066:Gonads / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008594:Menopause, Premature; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D012306:Risk
chemical_list: D000970:Antineoplastic Agents