title: Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules.
abstract: A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.
authors.affiliation: Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India.
authors.forename: Abha
authors.initials: A
authors.lastname: Chaudhary
authors.forename: Pralay
authors.initials: P
authors.lastname: Das
authors.forename: Awanish
authors.initials: A
authors.lastname: Mishra
authors.forename: Pushpinder
authors.initials: P
authors.lastname: Kaur
authors.forename: Bikram
authors.initials: B
authors.lastname: Singh
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Goel
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001567:Benzocycloheptenes / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D008954:Models, Biological; D012717:Sesquiterpenes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D001567:Benzocycloheptenes; D012717:Sesquiterpenes; D014753:Vinyl Compounds; C003763:vinyl bromide; C412292:himachalene