title: Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues.
abstract: First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H(37)Rv).
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
authors.forename: Pandrangi Siva
authors.initials: PS
authors.lastname: Swaroop
authors.forename: Gajanan N
authors.initials: GN
authors.lastname: Raut
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.forename: Priyanka
authors.initials: P
authors.lastname: Verma
authors.forename: Rajesh S
authors.initials: RS
authors.lastname: Gokhale
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013237:Stereoisomerism; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D001578:Benzopyrans