title: Risk factors for new-onset overactive bladder in older subjects: results of the Fujiwara-kyo study.
abstract: OBJECTIVE
  To evaluate the risk factors for new-onset overactive bladder (OAB) in older subjects.
  
  
  METHODS
  The present study enrolled 4427 subjects aged ≥ 65 years who had participated in the Fujiwara-kyo study. The prevalence of OAB at baseline and 1 year later was evaluated using the OAB symptom score questionnaire. The incidence and remission rate of OAB were calculated. We identified the risk factors for OAB by evaluating the difference in characteristics (including sex, age, body mass index, life style, comorbidities, depressive status, metabolic syndrome, and sum of voiding symptoms) between those with and without new-onset OAB. In addition, the independent risk factors were determined by multivariate analysis.
  
  
  RESULTS
  Of the 4427 subjects, 3685 completely replied to the self-administrated questionnaires at baseline and 1 year later. The incidence and remission rate of OAB was 11.9% and 29.8%, respectively. The male/female ratio, sum of voiding symptoms, alcohol consumption and smoking, hypertension, and depressive status in subjects with new-onset OAB, were significantly greater than those in subjects without new-onset OAB. A multivariate analysis, including sex (odds ratio 2.0, P < .0001), sum of voiding symptoms (odds ratio 1.1, P < .0001), and depressive status (odds ratio 1.8, P < .0001) were independent factors for new-onset OAB in older subjects.
  
  
  CONCLUSIONS
  The results of the present study have demonstrated that male sex, the sum of voiding symptoms, and depression were independent factors for new-onset OAB. It is necessary to determine whether the treatment of patients with voiding symptoms or depression controls for new-onset OAB.
authors.affiliation: Department of Urology, Nara Medical University, Nara, Japan. hirayamn@naramed-u.ac.jp
authors.forename: Akihide
authors.initials: A
authors.lastname: Hirayama
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Torimoto
authors.forename: Chie
authors.initials: C
authors.lastname: Mastusita
authors.forename: Nozomi
authors.initials: N
authors.lastname: Okamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Morikawa
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Kastunori
authors.initials: K
authors.lastname: Yoshida
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hirao
authors.forename: Norio
authors.initials: N
authors.lastname: Kurumatani
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors; D053201:Urinary Bladder, Overactive / Q000453:epidemiology*