title: Therapy related acute myeloid leukemia with t(10:16): a rare entity.
abstract: Treatment related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) are well known complications after chemotherapy for various hematologic and non-hematologic malignancies. Alkylating agents and Topoisomerase inhibitors are most widely studied in this regard. There is growing concern about occurrence of t-MDS, t-MDS/AML and t-AML in patients of CLL treated with nucleoside analogues especially in combination with alkylating agents. Exact incidence and pathogenesis of nucleoside analogue related MDS/AML is not clear at this time. We hereby report a case of t-AML in a patient treated with Fludarabine, Cyclophosphamide and Rituximab (FCR) for CLL. The cytogenetic studies revealed a unique translocation t (10:16), that has been reported in very few cases of therapy related AML and pediatric AML.
authors.affiliation: Temple University Hospital and.
authors.forename: Guldeep K
authors.initials: GK
authors.lastname: Uppal
authors.forename: John
authors.initials: J
authors.lastname: Leighton
authors.forename: Deline
authors.initials: D
authors.lastname: Da Costa
authors.forename: Andrew
authors.initials: A
authors.lastname: Czulewicz
authors.forename: Irma E
authors.initials: IE
authors.lastname: Palazzo