title: Enhancing effects of different dosages of borneol on pharmacokinetics of salvanic acid B after oral administration to rats.
abstract: The main purpose of this study was to illustrate the effect of borneol on pharmacokinetics of salvianolic acid B (SalB) in rats after oral administration of SalB with different doses of borneol. The concentrations of SalB in rat plasma were determined by an established and validated LC-MS/MS method. Our data showed that when 20, 40, and 80 mg kg⁻¹ of borneol were orally administrated with SalB at 50 mg kg⁻¹, C (max) of SalB was increased by 18.4%, 55.8%, and 103.2% compared with that of SalB alone. And AUC(0-t) of SalB in plasma was increased by 14.4%, 48.5%, and 123.3%, respectively. The results indicated that borneol is able to enhance the intestinal absorption and relative bioavailability of SalB, with a positive dose-dependent relationship. The described herb-drug interactions might prove the scientific rationality of the compatible ratio of traditional Chinese medicines.
authors.affiliation: Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Ren-Zhong
authors.forename: Xu
authors.initials: X
authors.lastname: Yan-Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Yan-Ping
authors.forename: Zhou
authors.initials: Z
authors.lastname: Mao-Jin
authors.forename: Liu
authors.initials: L
authors.lastname: Chang-Xiao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D001892:Camphanes / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008516:Medicine, Chinese Traditional; D051381:Rats; D053630:Depsides
chemical_list: D001572:Benzofurans; D001892:Camphanes; C076944:salvianolic acid B; D053630:Depsides; C022871:isoborneol