title: Developmental effects of decision-making on sensitivity to reward: an fMRI study.
abstract: Studies comparing neural correlates of reward processing across development yield inconsistent findings. This challenges theories characterizing adolescents as globally hypo- or hypersensitive to rewards. Developmental differences in reward sensitivity may fluctuate based on reward magnitude, and on whether rewards require decision-making. We examined whether these factors modulate developmental differences in neural response during reward anticipation and/or receipt in 26 adolescents (14.05±2.37 yrs) and 26 adults (31.25±8.23 yrs). Brain activity was assessed with fMRI during reward anticipation, when subjects made responses with-vs.-without decision-making, to obtain large-vs.-small rewards, and during reward receipt. When reward-receipt required decision-making, neural activity did not differ by age. However, when reward receipt did not require decision-making, neural activity varied by development, reward magnitude, and stage of the reward task. During anticipation, adolescents, but not adults, exhibited greater activity in the insula, extending into putamen, and cingulate gyrus for large-vs.-small incentives. During feedback, adults, but not adolescents, exhibited greater activity in the precuneus for large-vs.-small incentives. These data indicate that age-related differences in reward sensitivity cannot be characterized by global hypo- or hyper-responsivity. Instead, neural responding in striatum, prefrontal cortex and precuneus is influenced by both situational demands and developmental factors. This suggests nuanced maturational effects in adolescent reward sensitivity.
authors.affiliation: Section of Developmental and Affective Neuroscience, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Building 15 K, Bethesda, MD 20892, United States. johanna.jarcho@nih.gov
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Jarcho
authors.forename: Brenda E
authors.initials: BE
authors.lastname: Benson
authors.forename: Rista C
authors.initials: RC
authors.lastname: Plate
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Guyer
authors.forename: Allison M
authors.initials: AM
authors.lastname: Detloff
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Ellen
authors.initials: E
authors.lastname: Leibenluft
authors.forename: Monique
authors.initials: M
authors.lastname: Ernst
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology*; D000328:Adult; D000367:Age Factors; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000254:growth & development / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009042:Motivation / Q000502:physiology*; D012201:Reward