title: Use of antidementia drugs in frontotemporal lobar degeneration.
abstract: BACKGROUND
  Clinical evidence indicates that acetylcholinesterase inhibitors (AChEIs) are not efficacious to treat frontotemporal lobar degeneration (FTLD). The British Association for Psychopharmacology recommends avoiding the use of AChEI and memantine in patients with FTLD.
  
  
  METHODS
  Cross-sectional design using 1092 cases with Alzheimer's disease (AD) and 64 cases with FTLD registered by the Registry of Dementias of Girona. Bivariate analyses were performed, and binary logistic regressions were used to detect variables associated with antidementia drugs consumption.
  
  
  RESULTS
  The AChEIs were consumed by 57.6% and 42.2% of the patients with AD and FTLD, respectively. Memantine was used by 17.2% and 10.9% of patients with AD and FTLD, respectively. Binary logistic regressions yielded no associations with antidementia drugs consumption.
  
  
  CONCLUSIONS
  There is a discrepancy regarding clinical practice and the recommendations based upon clinical evidence. The increased central nervous system drug use detected in FTLD requires multicentric studies aiming at finding the best means to treat these patients.
authors.affiliation: Unitat de Recerca, Institut d'Assistència Sanitària, Salt, Spain.
authors.forename: Secundino
authors.initials: S
authors.lastname: López-Pousa
authors.forename: Laia
authors.initials: L
authors.lastname: Calvó-Perxas
authors.forename: Saioa
authors.initials: S
authors.lastname: Lejarreta
authors.forename: Marta
authors.initials: M
authors.lastname: Cullell
authors.forename: Rosa
authors.initials: R
authors.lastname: Meléndez
authors.forename: Erélido
authors.initials: E
authors.lastname: Hernández
authors.forename: Josep
authors.initials: J
authors.lastname: Bisbe
authors.forename: Héctor
authors.initials: H
authors.lastname: Perkal
authors.forename: Anna
authors.initials: A
authors.lastname: Manzano
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Roig
authors.forename: Oriol
authors.initials: O
authors.lastname: Turró-Garriga
authors.forename: Joan
authors.initials: J
authors.lastname: Vilalta-Franch
authors.forename: Josep
authors.initials: J
authors.lastname: Garre-Olmo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D012042:Registries; D012044:Regression Analysis
chemical_list: D002800:Cholinesterase Inhibitors; D008559:Memantine