title: Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry.
abstract: BACKGROUND
  Biomarkers have the potential to improve the clinical management of patients with AAA.
  
  
  METHODS
  A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89.
  
  
  CONCLUSIONS
  This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, UK. se63@le.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Ehsan
authors.forename: G
authors.initials: G
authors.lastname: Ball
authors.forename: E
authors.initials: E
authors.lastname: Choke
authors.forename: K M
authors.initials: KM
authors.lastname: Molyneux
authors.forename: N J M
authors.initials: NJ
authors.lastname: London
authors.forename: K E
authors.initials: KE
authors.lastname: Herbert
authors.forename: J
authors.initials: J
authors.lastname: Barratt
authors.forename: R D
authors.initials: RD
authors.lastname: Sayers
authors.forename: M J
authors.initials: MJ
authors.lastname: Bown
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D008297:Male; D011446:Prospective Studies; D040901:Proteomics / Q000379:methods; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers