title: Perioperative retinoic acid syndrome in a patient with acute promyelocytic leukemia.
abstract: All-trans retinoic acid (ATRA), a vitamin A derivative, is prescribed for induction of chemotherapy in patients with acute promyelocytic leukemia. Like other chemotherapy agents, ATRA has an adverse effect known as retinoic acid syndrome. The case of a 22 year old woman with acute promyelocytic leukemia, who received ATRA and subsequently developed retinoic acid syndrome, is presented. The patient's symptoms resolved after administration of dexamethasone, allowing the completion of chemotherapy without further complications.
authors.affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. usnickolay@gmail.com
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Usoltsev
authors.forename: M Saeed
authors.initials: MS
authors.lastname: Dhamee
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D007431:Intraoperative Complications / Q000139:chemically induced / Q000188:drug therapy; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced / Q000188:drug therapy; D013577:Syndrome; D014081:Tooth Extraction; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D014212:Tretinoin; D003907:Dexamethasone