title: Full-length genomic analysis of porcine G9P[23] and G9P[7] rotavirus strains isolated from pigs with diarrhea in South Korea.
abstract: Group A rotaviruses (RVAs) are agents causing severe gastroenteritis in infants and young animals. G9 RVA strains are believed to have originated from pigs. However, this genotype has emerged as the fifth major human RVA genotype worldwide. To better understand the relationship between human and porcine RVA strains, complete RVA genome data are needed. For human RVA strains, the number of complete genome data have grown exponentially. However, there is still a lack of complete genome data on porcine RVA strains. Recently, G9 RVA strains have been identified as the third most important genotype in diarrheic pigs in South Korea in combinations with P[7] and P[23]. This study is the first report on complete genome analyses of 1 G9P[7] and 3 G9P[23] porcine RVA strains, resulting in the following genotype constellation: G9-P[7]/P[23]-I5-R1-C1-M1-A8-N1-T1-E1-H1. By comparisons of these genotype constellations, it was revealed that the Korean G9P[7] and G9P[23] RVA strains possessed a typical porcine RVA backbone, similar to other known porcine RVA strains. However, detailed phylogenetic analyses revealed the presence of intra-genotype reassortments among porcine RVA strains in South Korea. Thus, our data provide genetic information of G9 RVA strains increasingly detected in both humans and pigs, and will help to establish the role of pigs as a source or reservoir for novel human RVA strains.
authors.affiliation: Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors.forename: Ha-Hyun
authors.initials: HH
authors.lastname: Kim
authors.forename: Jelle
authors.initials: J
authors.lastname: Matthijnssens
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyung-Jun
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Jun-Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Kyu-Yeol
authors.initials: KY
authors.lastname: Son
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Ryu
authors.forename: Deok-Song
authors.initials: DS
authors.lastname: Kim
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Mun-Il
authors.initials: MI
authors.lastname: Kang
authors.forename: Dong-Kun
authors.initials: DK
authors.lastname: Yang
authors.forename: Bang-Hun
authors.initials: BH
authors.lastname: Hyun
authors.forename: Sang-Ik
authors.initials: SI
authors.lastname: Park
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Kyoung-Oh
authors.initials: KO
authors.lastname: Cho
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003967:Diarrhea / Q000662:veterinary* / Q000821:virology; D016679:Genome, Viral; D005838:Genotype; D008969:Molecular Sequence Data; D058885:Multilocus Sequence Typing; D010802:Phylogeny; D056910:Republic of Korea; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D034421:Sus scrofa / Q000821:virology*