title: [Impact of periodontal disease on arterial pressure in diabetic mice].
abstract: Diabetes-driven cardiovascular diseases represent a high challenge for developed countries. Periodontal disease is strictly linked to the aforementioned diseases, due to its Gram negative-driven inflammation. Thus, we investigated the effects of periodontal disease on arterial pressure during the development of diabetes in mice. To this aim, C57BL/6 female mice were colonized with pathogens of periodontal tissue (Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum) for 1month, whereas another group of mice did not undergo the colonization. Subsequently, all mice were fed a high-fat carbohydrate-free diet for 3months. Then, arterial pressure was measured in vivo and a tomodensitometric analysis of mandibles was realized as well. Our results show increased mandibular bone-loss induced by colonization with periopathogens. In addition, periodontal infection augmented glucose-intolerance and systolic and diastolic arterial pressure, parameters already known to be affected by a fat-diet. In conclusion, we show here that periodontal disease amplifies metabolic troubles and deregulates arterial pressure, emerging as a new axis of metabolic investigation.
authors.affiliation: Parodontites et maladies générales LU 51, faculté de chirurgie dentaire, 3, chemin des Maraîchers, 31062 Toulouse cedex, France. vincent.blasco@inserm.fr
authors.forename: V
authors.initials: V
authors.lastname: Blasco-Baque
authors.forename: P
authors.initials: P
authors.lastname: Kémoun
authors.forename: P
authors.initials: P
authors.lastname: Loubieres
authors.forename: M
authors.initials: M
authors.lastname: Roumieux
authors.forename: C
authors.initials: C
authors.lastname: Heymes
authors.forename: M
authors.initials: M
authors.lastname: Serino
authors.forename: M
authors.initials: M
authors.lastname: Sixou
authors.forename: R
authors.initials: R
authors.lastname: Burcelin
mesh_terms: D016301:Alveolar Bone Loss / Q000382:microbiology; D000818:Animals; D062186:Arterial Pressure; D002318:Cardiovascular Diseases / Q000276:immunology / Q000382:microbiology; D048909:Diabetes Complications / Q000276:immunology / Q000382:microbiology*; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D016967:Fusobacterium nucleatum / Q000254:growth & development; D007333:Insulin Resistance / Q000276:immunology; D008336:Mandibular Diseases / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D010510:Periodontal Diseases / Q000382:microbiology*; D010512:Periodontal Index; D016966:Porphyromonas gingivalis / Q000254:growth & development; D018713:Prevotella intermedia / Q000254:growth & development