title: Elevated circulating tissue factor procoagulant activity, factor VII, and plasminogen activator inhibitor-1 in childhood obesity: evidence of a procoagulant state.
abstract: Childhood obesity is rapidly increasing in prevalence. We compared circulating membrane-bound tissue factor (FIII, F3) procoagulant activity (TF-PCA) and plasma markers of coagulation, fibrinolysis and endothelial dysfunction in 21 obese (10·1 ± 1·5 years, mean ± standard deviation) and 22 healthy weight children (9·9 ± 1·6 years), classified by Body Mass Index (BMI). TF-PCA and factor VII coagulant activity (FVII:C), plasminogen activator inhibitor (PAI-1, SERPINE1) and soluble vascular cell adhesion molecule 1 (sVCAM1) were higher in obese children. BMI correlated positively with TF-PCA, FVII:C, and PAI-1. Childhood obesity is associated with a procoagulant state and endothelial dysfunction. Studies are needed to assess whether weight reduction reverses these abnormalities.
authors.affiliation: Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: Anamika
authors.initials: A
authors.lastname: Singh
authors.forename: Gary D
authors.initials: GD
authors.lastname: Foster
authors.forename: Jay
authors.initials: J
authors.lastname: Gunawardana
authors.forename: Tara Alexis
authors.initials: TA
authors.lastname: McCoy
authors.forename: Tina
authors.initials: T
authors.lastname: Nguyen
authors.forename: Stephanie
authors.initials: S
authors.lastname: Vander Veur
authors.forename: Eugene
authors.initials: E
authors.lastname: Komaroff
authors.forename: Angara Koneti
authors.initials: AK
authors.lastname: Rao
mesh_terms: D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000032:analysis*; D001800:Blood Specimen Collection / Q000379:methods; D015992:Body Mass Index; D002648:Child; D005167:Factor VII / Q000032:analysis; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D013925:Thromboplastin / Q000032:analysis
chemical_list: D015415:Biomarkers; D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; D005167:Factor VII; D013925:Thromboplastin