title: Nitric oxide transport in an axisymmetric stenosis.
abstract: To test the hypothesis that disturbed flow can impede the transport of nitric oxide (NO) in the artery and hence induce atherogenesis, we used a lumen-wall model of an idealized arterial stenosis with NO produced at the blood vessel-wall interface to study the transport of NO in the stenosis. Blood flows in the lumen and through the arterial wall were simulated by Navier-Stokes equations and Darcy's Law, respectively. Meanwhile, the transport of NO in the lumen and the transport of NO within the arterial wall were modelled by advection-diffusion reaction equations. Coupling of fluid dynamics at the endothelium was achieved by the Kedem-Katchalsky equations. The results showed that both the hydraulic conductivity of the endothelium and the non-Newtonian viscous behaviour of blood had little effect on the distribution of NO. However, the blood flow rate, stenosis severity, red blood cells (RBCs), RBC-free layer and NO production rate at the blood vessel-wall interface could significantly affect the transport of NO. The theoretical study revealed that the transport of NO was significantly hindered in the disturbed flow region distal to the stenosis. The reduced NO concentration in the disturbed flow region might play an important role in the localized genesis and development of atherosclerosis.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
authors.forename: X Yun
authors.initials: XY
authors.lastname: Xu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
mesh_terms: D001158:Arteries / Q000378:metabolism* / Q000473:pathology; D001692:Biological Transport; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003251:Constriction, Pathologic / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D004912:Erythrocytes / Q000378:metabolism; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide