title: Drug interactions: the importance of looking inside cancer cells.
abstract: nab-Paclitaxel increased intratumoral gemcitabine levels by reactive oxygen species-mediated degradation of cytidine deaminase, the rate-limiting enzyme in gemcitabine inactivation. This not only has implications for how this drug combination mediates anticancer effects but also demonstrates the importance of evaluating mechanisms of drug activity within malignant cells.
authors.affiliation: Massachusetts General Hospital, Boston, MA 02114, USA. jclark@partners.org
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Clark
mesh_terms: D000418:Albumins / Q000494:pharmacology*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy*; D003564:Cytidine Deaminase / Q000378:metabolism*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D017239:Paclitaxel / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D003841:Deoxycytidine; D003564:Cytidine Deaminase; D017239:Paclitaxel; D000093542:Gemcitabine