title: Comparison of risk of malignancy indices; RMI 1-4 in borderline ovarian tumor.
abstract: OBJECTIVE
  The aim of this study was to evaluate prognostic values of the risk of malignancy index (RMI)/1-4 in patients with borderline ovarian tumors (BOTs).
  
  
  METHODS
  The study consisted of 50 patients with BOT diagnosed and treated between 2005-2010 and 50 patients with benign adnexal massses between 2009-2010 as a control comparison group in the retropsective study. Preoperative serum CA125, U score, tumor size (S), and menopausal status were recorded. The RMI 1-3 was calculated according to the formula; UxMxCA125 and RMI4 formulation was; UxMxCA125xS. S equaled 1 for tumor size <7 cm and was 2 when size a 7 cm. The RMI 1-4 indices were calculated for all patients together with the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy (DA). The performances of RMI indices were evaluated by McNemar's test and determined the best score cutoff value by the receiver operating characteristic (ROC) curve.
  
  
  RESULTS
  The mean age, median value of CA125, ultrasound score, menopausal status, median values of RMI 1-4 of BOTs were statistically higher than benign adnexal masses. The sensitivity of RMI 1-4 was 26, 36, 62, and 60% at cutoff 200 level, respectively. The areas under curve of RMI 1-4 were found to be 0.676, 0.665, 0.668 and 0.734, respectively. DA of RMI 1-4 was found to be 56, 59, 50, and 71, respectively. When RMI 1-4 indices were compared with each other RMI 4 was the best RMI for BOTs.
  
  
  CONCLUSIONS
  RMI 4 was the best predictive RMI for preoperative discrimination of BOT at a cutoff level of 200.
authors.affiliation: Obstetrics and Gynecology Department, Gulhane Military Medical Faculty, Etlik, Ankara, Turkey.
authors.forename: M C
authors.initials: MC
authors.lastname: Yenen
authors.forename: I
authors.initials: I
authors.lastname: Alanbay
authors.forename: E
authors.initials: E
authors.lastname: Aktürk
authors.forename: C M
authors.initials: CM
authors.lastname: Ercan
authors.forename: H
authors.initials: H
authors.lastname: Coksuer
authors.forename: E
authors.initials: E
authors.lastname: Karaşahin
authors.forename: H
authors.initials: H
authors.lastname: Ozan
authors.forename: M
authors.initials: M
authors.lastname: Dede
mesh_terms: D000291:Adnexal Diseases / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000328:Adult; D019540:Area Under Curve; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D018394:CA-125 Antigen