title: The uncoupling protein 2 -866G > a polymorphism is associated with the risk of ischemic stroke in Chinese type 2 diabetic patients.
abstract: OBJECTIVE
  To determine genetic predispsitions for diabetic cerebral ischemia, we investigated the relationship between the -866G>A polymorphism of uncoupling protein (UCP) 2 and the risk of ischemic stroke in two cohorts of type 2 diabetic patients.
  
  
  METHODS
  A total of 844 type 2 diabetic patients with 4-year prospective study were examined using a case-control methodology. And 404 cases with ischemical stroke, 440 cases without ischemical stroke. The -866G>A polymorphism in UCP2 was genotyped by TaqMan MGB probe method.
  
  
  RESULTS
  The -866G>A SNP in UCP2 was significantly associated with diabetic ischemical stroke (odds ratio [OR]= 1.94; 95% confidence interval [CI]= 0.68 to1.31; P < 0.037). Similar results were observed for baseline cases of IS. Stratification by sex confirmed an allelic association with IS in women, whereas no association was observed in men.
  
  
  CONCLUSIONS
  The A allele of the -866G>A variant of UCP2 was associated with increased risk of IS in Chinese diabetic women with type 2 diabetes in a 4-year prospective study. This association was independent of other common IS risk factors.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Department of Anatomy Histology and Pharmacology, Laboratory of Neuropharmacology, School of Life Sciences, Nanjing University, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chai
authors.forename: Bing
authors.initials: B
authors.lastname: Gu
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Qiu
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Yi
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhu
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2; D004247:DNA