title: In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus.
abstract: LTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and linezolid, by microdilution tests to determine MICs. Time-kill assays were performed against representative MRSA, vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) isolates. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.
authors.affiliation: St. John Hospital and Medical Center, Detroit, Michigan, USA. louis.saravolatz@stjohn.org
authors.forename: Louis D
authors.initials: LD
authors.lastname: Saravolatz
authors.forename: Joan
authors.initials: J
authors.lastname: Pawlak
authors.forename: Leonard
authors.initials: L
authors.lastname: Johnson
authors.forename: Hector
authors.initials: H
authors.lastname: Bonilla
authors.forename: Louis D
authors.initials: LD
authors.lastname: Saravolatz
authors.forename: Mohamad G
authors.initials: MG
authors.lastname: Fakih
authors.forename: Anders
authors.initials: A
authors.lastname: Fugelli
authors.forename: Wenche Marie
authors.initials: WM
authors.lastname: Olsen
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D000069349:Linezolid; D008712:Methicillin / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D023303:Oxazolidinones; D014640:Vancomycin; C568461:L-arginyl-2,5,7-tris(1,1-dimethylethyl)-L-tryptophyl-N-(2-phenylethyl)-L-argininamide; D000069349:Linezolid; D017576:Daptomycin; D008712:Methicillin