title: Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.
abstract: Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MM-derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.
authors.affiliation: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, Geneva, Switzerland.
authors.forename: Silvia I
authors.initials: SI
authors.lastname: Anghel
authors.forename: Rafael
authors.initials: R
authors.lastname: Correa-Rocha
authors.forename: Rafael
authors.initials: R
authors.lastname: Correa-Rochal
authors.forename: Eva
authors.initials: E
authors.lastname: Budinska
authors.forename: Kayluz F
authors.initials: KF
authors.lastname: Boligan
authors.forename: Kayluz F
authors.initials: KF
authors.lastname: Boliganl
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Abraham
authors.forename: Sara
authors.initials: S
authors.lastname: Colombetti
authors.forename: Lionel
authors.initials: L
authors.lastname: Fontao
authors.forename: Agnese
authors.initials: A
authors.lastname: Mariotti
authors.forename: Donata
authors.initials: D
authors.lastname: Rimoldi
authors.forename: Ghanem E
authors.initials: GE
authors.lastname: Ghanem
authors.forename: David E
authors.initials: DE
authors.lastname: Fisher
authors.forename: Frederic
authors.initials: F
authors.lastname: Lévy
authors.forename: Mauro
authors.initials: M
authors.lastname: Delorenzi
authors.forename: Vincent
authors.initials: V
authors.lastname: Piguet
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D051379:Mice; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D055757:SOXE Transcription Factors / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D051739:Microphthalmia-Associated Transcription Factor; D009363:Neoplasm Proteins; C527923:SOX10 protein, human; D055757:SOXE Transcription Factors; D025521:Tumor Suppressor Proteins; C109969:VWA5A protein, human