title: Treatment of obesity as a potential complementary approach to cancer therapy.
abstract: Obesity has long been recognized as a risk factor for diabetes and cardiovascular disease. Recent epidemiological data also associate obesity with cancer risk and progression. For this reason, a combination treatment of obesity along with treatment of the cancer itself may improve patient survival and well-being. As the molecular pathways linking obesity and cancer become better understood, new potential therapy targets are surfacing. In this article, we summarize the mechanisms proposed to account for the obesity-cancer association and discuss approaches to manipulation of adipose tissue as potential interventions aimed at cancer prevention or supplemental therapy.
authors.affiliation: Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Sirin
authors.forename: Mikhail G
authors.initials: MG
authors.lastname: Kolonin
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D009765:Obesity / Q000378:metabolism / Q000628:therapy*
chemical_list: D019440:Anti-Obesity Agents; D007004:Hypoglycemic Agents