title: PRDB: Protein Repeat DataBase.
abstract: Rapidly increasing genomic data present new challenges for scientists: making sense of millions of amino acid sequences requires a systematic approach and information about their 3D structure, function, and evolution. Over the last decade, numerous studies demonstrated the fundamental importance of protein tandem repeats and their involvement in human diseases. Bioinformatics analysis of these regions requires special computer programs and databases, since the conventional approaches predominantly developed for globular domains have limited success. To perform a global comparative analysis of protein tandem repeats, we developed the Protein Tandem Repeat DataBase (PRDB). PRDB is a curated database that includes the protein tandem repeats found in sequence databanks by the T-REKS program. The database is available at http://bioinfo.montp.cnrs.fr/?r=repeatDB.
authors.affiliation: Centre de Recherches de Biochimie Macromoléculaire UMR 5237, CNRS, University of Montpellier 1 and 2, Montpellier, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Jorda
authors.forename: Thierry
authors.initials: T
authors.lastname: Baudrand
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Kajava
mesh_terms: D003628:Database Management Systems; D030562:Databases, Protein; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D040901:Proteomics / Q000379:methods*; D020449:Repetitive Sequences, Amino Acid; D020539:Sequence Analysis, Protein / Q000379:methods*; D020080:Tandem Repeat Sequences
chemical_list: D011506:Proteins