title: A new target for therapy in squamous cell carcinoma of the lung.
abstract: Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung. Cellular, biochemical, and human data suggest that tumor cells harboring DDR2 mutations have increased sensitivity to existing tyrosine kinase inhibitors, providing rationale for clinical trials of agents that inhibit DDR2 kinase in the disease.
authors.affiliation: Department of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
authors.forename: Kadoaki
authors.initials: K
authors.lastname: Ohashi
authors.forename: William
authors.initials: W
authors.lastname: Pao
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D000070818:Discoidin Domain Receptors; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D011975:Receptors, Mitogen / Q000235:genetics*
chemical_list: D011975:Receptors, Mitogen; D000070818:Discoidin Domain Receptors; D020794:Receptor Protein-Tyrosine Kinases