title: Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile.
abstract: Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.
authors.affiliation: Nanomedicine Laboratory, Centre for Drug Delivery Research, UCL School of Pharmacy, University College London, London WC1N 1AX, UK.
authors.forename: Khuloud T
authors.initials: KT
authors.lastname: Al-Jamal
authors.forename: Antonio
authors.initials: A
authors.lastname: Nunes
authors.forename: Laura
authors.initials: L
authors.lastname: Methven
authors.forename: Hanene
authors.initials: H
authors.lastname: Ali-Boucetta
authors.forename: Shouping
authors.initials: S
authors.lastname: Li
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Toma
authors.forename: M Antonia
authors.initials: MA
authors.lastname: Herrero
authors.forename: Wafa' T
authors.initials: WT
authors.lastname: Al-Jamal
authors.forename: Huub M M
authors.initials: HM
authors.lastname: ten Eikelder
authors.forename: Julie
authors.initials: J
authors.lastname: Foster
authors.forename: Stephen
authors.initials: S
authors.lastname: Mather
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
mesh_terms: D000588:Amines / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009928:Organ Specificity
chemical_list: D000588:Amines; D037742:Nanotubes, Carbon