title: Impact of excipient interactions on drug bioavailability from solid dosage forms.
abstract: Excipients are generally pharmacologically inert, but can interact with drugs in the dosage form and the physiological factors at the site of absorption to affect the bioavailability of a drug product. A general mechanistic understanding of the basis of these interactions is essential to design robust drug products. This paper focuses on drug-excipient interactions in solid dosage forms that impact drug bioavailability, the drug substance and drug product properties affected by excipients, and the impact of excipients on physiologic processes. The extent to which drug bioavailability is affected by these interactions would vary on a case-by-case basis depending upon factors such as the potency and dose of the drug, therapeutic window, site of absorption, rate limiting factor in drug absorption (e.g., permeability or solubility limited), or whether drug metabolism, efflux, complexation, or degradation at the site of absorption play a role in determining its bioavailability. Nonetheless, a mechanistic understanding of drug-excipient interactions and their impact on drug release and absorption can help develop formulations that exhibit optimum drug bioavailability.
authors.affiliation: Department of Biopharmaceutical Sciences, Roosevelt University, 1400 N Roosevelt Blvd., SCH 250, Schaumburg, Illinois, 60173, USA. rpanakanti@roosevelt.edu
authors.forename: Ravikiran
authors.initials: R
authors.lastname: Panakanti
authors.forename: Ajit S
authors.initials: AS
authors.lastname: Narang
mesh_terms: D000042:Absorption; D000818:Animals; D001682:Biological Availability; D004304:Dosage Forms; D005079:Excipients / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D004304:Dosage Forms; D005079:Excipients; D004364:Pharmaceutical Preparations