title: Genetic polymorphisms of HO-1 and COX-1 are associated with aspirin resistance defined by light transmittance aggregation in Chinese Han patients.
abstract: BACKGROUND
  Cyclooxygenase 1 (COX-1), COX-2, and HO-1 are involved in the process of aspirin's effect. The genetic susceptibility of these enzymes to aspirin resistance (AR) is unclear.
  
  
  METHODS
  A total of 431 patients took aspirin. Using arachidonic acid-induced light transmittance aggregation combined with adenosine diphosphate-induced light transmittance aggregation, 36 participants served for AR, 164 participants for semi-AR, and 231 participants for aspirin sensitivity (AS). The AR with 9 single-nucleotide polymorphism in COX-1, COX-2, and HO-1 genes was investigated.
  
  
  RESULTS
  COX-1 rs1330344 (-1676A>G) is associated with AR. G-Allele carriers significantly increased the risk of AR. For patients with AS as control, P is .02 (odds ratio [OR] = 1.77, confidence interval [CI]: 1.07-2.92). For patients with semi-AR as control, P is .05. HO-1 rs2071746 (-413A>T) is associated with AR. T-Allele carriers significantly increased the risk of AR. For patients with AS as control, P is .04 (OR = 1.70, CI: 1.02-2.79). For patients with semi-AR as control, P is .05 (OR = 1.68, CI: 1.00-2.80).
  
  
  CONCLUSIONS
  rs2071746 in HO-1 gene, rs1330344 in COX-1 gene contribute to AR.
authors.affiliation: 1First Department of Geriatric Cardiology of South Building, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Cui
authors.forename: Ya-Zhen
authors.initials: YZ
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Ruo-Jun
authors.initials: RJ
authors.lastname: Wu
authors.forename: Feng-chun
authors.initials: FC
authors.lastname: Zhou
authors.forename: Jun-hong
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000368:Aged; D044466:Asian People; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000737:chemistry / Q000166:cytology / Q000187:drug effects; D051545:Cyclooxygenase 1 / Q000235:genetics*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D020641:Polymorphism, Single Nucleotide; D012542:Scattering, Radiation
chemical_list: D016861:Cyclooxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin