title: A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry.
abstract: Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.
authors.affiliation: Department of Pathology, Kansai Rosai Hospital, Inabaso, Amagasaki, Hyogo 660-8511, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Isao
authors.initials: I
authors.lastname: Taguchi
authors.forename: Tadasuke
authors.initials: T
authors.lastname: Nagatomo
authors.forename: Michiaki
authors.initials: M
authors.lastname: Yamane
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugio
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yoshino
authors.forename: Kazuko
authors.initials: K
authors.lastname: Oku
authors.forename: Teruaki
authors.initials: T
authors.lastname: Nagano
authors.forename: Hayato
authors.initials: H
authors.lastname: Kimura
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakajo
authors.forename: Gaku
authors.initials: G
authors.lastname: Kawabata