title: In vivo evaluation of resorbable bone graft substitutes in mandibular sockets of the beagle.
abstract: Hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)), with its high biocompatibility and good bioaffinity, stimulates osteoconduction and is slowly replaced by the host bone after implantation. However, clinical use of HA as a bone substitute has proved problematic. It is difficult to prevent dispersion of the HA granules and to mold the granules into the desired shape. Calcium sulfate as a bone graft substitute is rapidly resorbed in vivo releasing calcium ions, but fails to provide a long-term, three-dimensional framework to support osteoconduction. The setting properties of calcium sulfate, however, allow it to be applied in a slurry form, making it easier to handle and apply in different situations. This study examines the in vivo response of a (Hydroxyapatite, apatitic phase)/calcium sulfate dehydrate (CSD) composite using different ratios in the mandibular premolar sockets of the beagle. The HA (AP)/CSD composite materials prepared in ratios of 30/70, 50/50, and 70/30 were implanted into the mandibular premolar sockets for 5 and 10 weeks. The control socket was empty. The authors compared the radiographic properties and the changes in height and width of the mandibular premolar sockets in the beagle. The composite graft in the 30/70 ratio had the best ability to form new bones.
authors.affiliation: School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan, Republic of China.
authors.forename: Tsai-Chin
authors.initials: TC
authors.lastname: Shih
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Chang
authors.forename: Jen-Chang
authors.initials: JC
authors.lastname: Yang
authors.forename: Sheng-Wei
authors.initials: SW
authors.lastname: Feng
authors.forename: Che-Tong
authors.initials: CT
authors.lastname: Lin
authors.forename: Nai-Chia
authors.initials: NC
authors.lastname: Teng
mesh_terms: D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D000818:Animals; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation; D002133:Calcium Sulfate / Q000494:pharmacology; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology; D008334:Mandible / Q000000981:diagnostic imaging / Q000187:drug effects*; D008422:Materials Testing / Q000379:methods*; D010012:Osteogenesis / Q000187:drug effects; D011859:Radiography; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D017886:Durapatite; D002133:Calcium Sulfate