title: Pseudotumoral cutaneous aspergillosis in chronic granulomatous disease, report of a pediatric case.
abstract: Invasive aspergillosis is a life-threatening condition in patients with chronic granulomatous disease (CGD). Skin invasion by Aspergillus occurs most commonly by contiguity to a neighboring cavity. We describe an unusual case of invasive cutaneous aspergillosis presented as a large burgeoning tumor in a 4-year-old girl with CGD who underwent surgical treatment for bifocal osteomyelitis of the left leg. The skin invasion occurred 4 months after a "successful" treatment of invasive pulmonary aspergillosis. Atypical presentation and diagnostic difficulties are discussed. Invasive cutaneous aspergillosis may be polymorphic. The diagnosis should be considered early in the etiological investigation of any suspicious skin lesions in CGD even in uncommon aspects such as burgeoning tumors.
authors.affiliation: Pediatric A Department, Children's Hospital of Tunis, Faculty of Medicine, University of Tunis El manar, Tunisia. monia.khemiri@rns.tn
authors.forename: Monia
authors.initials: M
authors.lastname: Khemiri
authors.forename: Nadia
authors.initials: N
authors.lastname: El fekih
authors.forename: Aida
authors.initials: A
authors.lastname: Borgi
authors.forename: Monia
authors.initials: M
authors.lastname: Kharfi
authors.forename: Samir
authors.initials: S
authors.lastname: Boubaker
authors.forename: Sihem
authors.initials: S
authors.lastname: Barsaoui
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D003646:Debridement; D003881:Dermatomycoses / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D004322:Drainage / Q000009:adverse effects*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D010019:Osteomyelitis / Q000175:diagnosis / Q000382:microbiology / Q000601:surgery*; D012867:Skin / Q000382:microbiology* / Q000473:pathology; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents