title: Symptom structure of antipsychotic-induced obsessive compulsive symptoms in schizophrenia patients.
abstract: OBJECTIVE
  The use of clozapine or other second generation antipsychotics (SGAs) has been reported to produce obsessive compulsive (OC) symptoms as adverse mental affects. However, it is not yet clear if SGA-induced OC symptoms have the same phenomenological characteristics as those displayed in obsessive compulsive disorder (OCD). This study investigated the nature of symptoms and dimensions of SGA-induced OC symptoms in schizophrenia patients, which were then compared with those reported in pure OCD.
  
  
  METHODS
  The study subjects were fifty-one schizophrenia patients with SGA-induced OC symptoms. Symptom evaluation was performed using the Korean version of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Exploratory factor analysis of symptom categories of Y-BOCS symptom checklist (Y-BOCS-SC) was conducted.
  
  
  RESULTS
  Frequencies of individual symptom categories were comparable to those reported in Korean OCD patients. Five factors (forbidden thoughts, hoarding, cleaning, symmetry, and counting) were generated from 13 main symptom categories, which accounted for 70.7% of the total variance. This factor structure is also remarkably similar to those reported in pure OCD patients. The factor score of 'cleaning' was significantly correlated with the overall severity of OC symptoms (P<0.01).
  
  
  CONCLUSIONS
  A high level of similarity between the nature of symptoms and dimensions identified in patients with SGA-induced OC symptoms and those revealed in OCD patients suggests a common biological mechanism underlying these two clinical conditions.
authors.affiliation: Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Seunghyong
authors.initials: S
authors.lastname: Ryu
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Nam
authors.forename: Meerae
authors.initials: M
authors.lastname: Lim
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Baek
authors.forename: Yeon Ho
authors.initials: YH
authors.lastname: Joo
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
authors.forename: Tae Hyon
authors.initials: TH
authors.lastname: Ha
authors.forename: Kyung Sue
authors.initials: KS
authors.lastname: Hong
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D063189:Symptom Assessment / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D014150:Antipsychotic Agents