title: IL-13 Signaling in Liver Fibrogenesis.
abstract: Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g., collagens or connective tissue growth factor, in hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis have been uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis.
authors.affiliation: Molecular Hepatology - Alcohol Associated Diseases, II. Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg Mannheim, Germany.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Stefan
authors.initials: S
authors.lastname: Munker
authors.forename: Roman
authors.initials: R
authors.lastname: Müllenbach
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Weng