title: Constrained evolution drives limited influenza diversity.
abstract: H3N2 influenza A viruses have been widely circulating in human populations since the pandemic of 1968. A striking feature of the evolutionary development of this strain has been its 'canalized' nature, with narrow evolutionary trees dominated by long trunks with few branching, or bifurcation events and a consequent lack of standing diversity at any single point. This is puzzling, as one might expect that the strong human immune response against the virus would create an environment encouraging more diversity, not less. Previous models have used various assumptions in order to account for this finding. A new analysis published in BMC Biology suggests that this processive evolution down a single path can be recapitulated by a relatively simple model incorporating only two primary parameters - the mutation rate of the virus, and the immunological distance created by each mutation - so long as these parameters are within a particular narrow but biologically plausible range.
authors.affiliation: Department of Immunology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. paul.thomas@stjude.org
authors.forename: Paul G
authors.initials: PG
authors.lastname: Thomas
authors.forename: Tomer
authors.initials: T
authors.lastname: Hertz
mesh_terms: D000940:Antigenic Variation; D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics* / Q000276:immunology*; D007251:Influenza, Human / Q000821:virology*
chemical_list: D000956:Antigens, Viral