title: Antitumour-promoting and cytotoxic constituents of etlingera elatior.
abstract: Phytochemical studies on rhizome of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13-trien-16,15-olide (4), stigmast-4-en-3-one (5), stigmast-4-ene-3,6-dione (6), stigmast-4-en-6b-ol-3-one (7), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (8). 1 and 4 were new compounds. Compounds 5 and 7 displayed high antitumour-promoting activity. Ethyl acetate extract showed a very significant cytotoxic activity against CEM-SS and MCF-7 cell lines (4 μg/ml and 6.25 μg/ml respectively). The antitumour-promoting activity was determined by EBV-EA assay and cytotoxic activity was determined by MTT assay.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, University College of Science and Technology Malaysia (KUSTEM), Mengabang Telipot, 21030 Kuala Terengganu, Terengganu, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Habsah
authors.forename: Am
authors.initials: A
authors.lastname: Ali
authors.forename: Nh
authors.initials: N
authors.lastname: Lajis
authors.forename: Ma
authors.initials: M
authors.lastname: Sukari
authors.forename: Yh
authors.initials: Y
authors.lastname: Yap
authors.forename: H
authors.initials: H
authors.lastname: Kikuzaki
authors.forename: N
authors.initials: N
authors.lastname: Nakatani