title: Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction.
abstract: Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively reduced both histamine and serotonin (5-HT)-induced vascular permeability in rats. CAPE also reduced histamine and leukotrienes (LTs) release from isolated rat peritoneal mast cells. Moreover, CAPE suppressed contraction induced by histamine (3 × 10(-8)-3 × 10(-5) M), 5-HT (3 × 10(-9)-10(-6) M) and adenosine (3 × 10(-8)-10(-5) M) in guinea pig tracheal zigzag. These findings provide evidence that CAPE may serve as an effective therapeutic agent for allergic diseases.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. manarahna@yahoo.com
authors.forename: Manar A
authors.initials: MA
authors.lastname: Nader
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D018926:Anti-Allergic Agents / Q000276:immunology / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects / Q000276:immunology; D006168:Guinea Pigs; D006632:Histamine / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects / Q000276:immunology; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D015289:Leukotrienes / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects / Q000276:immunology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000276:immunology; D014661:Vasoconstriction / Q000187:drug effects / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D002109:Caffeic Acids; D015289:Leukotrienes; D012701:Serotonin; D007073:Immunoglobulin E; D006632:Histamine; C055494:caffeic acid phenethyl ester; D000241:Adenosine; D010626:Phenylethyl Alcohol