title: The effects of rehabilitative training on the behaviors of Parkinson's disease mouse and underlying mechanism.
abstract: OBJECTIVE
  To examine the effects of rehabilitative training on mice behavior improvement in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD).
  
  
  METHODS
  MPTP mice model of Parkinson disease was generated. The rehabilitative training included daily running wheel and balance walking; the control group was allowed for free activity. The behaviors of the two groups were investigated at 1 week, 2 weeks, and 4 weeks and the content of dopamine (DA) in striatum of different groups of mice was measured with high-performance liquid chromatography (HPLC).
  
  
  RESULTS
  The results showed that as compared to the control group, the score of climbing pole, traction, swimming tests, and dopamine content was improved in the rehabilitative training group.
  
  
  CONCLUSIONS
  This suggested that rehabilitative training could improve the locomotor ability and dopamine content in PD mouse model.
authors.affiliation: The Rehabilitation Center, The Fifth Affiliated Hospital, Zhengzhou University,   Zhengzhou,   China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yue
authors.forename: Ganghua
authors.initials: G
authors.lastname: Guo
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D020267:MPTP Poisoning / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000379:methods*