title: Myo/Nog cells in normal, wounded and tumor-bearing skin.
abstract: Murine and human skin were examined for the presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, Myo/Nog cells increase in number in the follicles and appear in the wound. Myo/Nog cells are also recruited to the stroma of tumors formed from v-Ras-transformed keratinocytes (Ker/Ras). Human squamous cell carcinomas and malignant melanomas contain significantly more Myo/Nog cells than basal cell carcinomas. Myo/Nog cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. Myo/Nog cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Gerhart
authors.forename: Candace
authors.initials: C
authors.lastname: Hayes
authors.forename: Victoria
authors.initials: V
authors.lastname: Scheinfeld
authors.forename: Michael
authors.initials: M
authors.lastname: Chernick
authors.forename: Susan
authors.initials: S
authors.lastname: Gilmour
authors.forename: Mindy
authors.initials: M
authors.lastname: George-Weinstein
mesh_terms: D000818:Animals; D002280:Basal Cell Carcinoma / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000378:metabolism; D051379:Mice; D017570:MyoD Protein / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D014947:Wounds and Injuries / Q000378:metabolism*; D000099176:Noggin Protein
chemical_list: D002352:Carrier Proteins; D017570:MyoD Protein; D000099176:Noggin Protein