title: Three decades of Wnts: a personal perspective on how a scientific field developed.
abstract: Wnt genes and components of Wnt signalling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviours to several diseases, especially cancers. Emergence of the field of Wnt signalling can be largely traced back to the discovery of the first mammalian Wnt gene in 1982. In this essay, we mark the thirtieth anniversary of that discovery by describing some of the critical scientific developments that led to the flowering of this field of research.
authors.affiliation: Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University, School of Medicine, CA 94305-5458, USA. rnusse@stanford.edu
authors.forename: Roel
authors.initials: R
authors.lastname: Nusse
authors.forename: Harold
authors.initials: H
authors.lastname: Varmus
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000266:history; D005786:Gene Expression Regulation; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008954:Models, Biological; D060449:Wnt Signaling Pathway