title: Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive deterioration and neuropsychiatric symptoms. Sensorimotor gating deficit has been identified in neuropsychiatric diseases. The aim of the present study was to evaluate the possible sensorimotor gating deficit and its correlation to memory impairment and cerebral β-amyloid (Aβ) plaque deposits in an amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mouse model of AD. The sensorimotor gating in 3-, 7- and-22-month-old non-transgenic and transgenic mice was evaluated in a prepulse inhibition (PPI) task. Results revealed that the PPI was lower in the 7- and 22-month-old transgenic mice compared with the age-matched control, while the response to startle pulse-alone in the transgenic and non-transgenic mice was comparable. Congo red staining showed that Aβ neuropathology of transgenic mice aggravated with age, and the 3-month-old transgenic mice started to have minimum brain Aβ plaques, corresponding to the early stage of AD phenotype. Furthermore, memory impairment in the 7-month-old transgenic mice was detected in a water maze test. These results suggest that the sensorimotor gating is impaired with the progressing of AD phenotype, and its deficit may be correlated to cerebral Aβ neuropathology and memory impairment in the APP/PS1 transgenic mouse model of AD.
authors.affiliation: Department of Clinical Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, PR China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Wang
authors.forename: Jue
authors.initials: J
authors.lastname: He
authors.forename: Ruiguo
authors.initials: R
authors.lastname: Zhang
authors.forename: Shenghua
authors.initials: S
authors.lastname: Zhu
authors.forename: Junhui
authors.initials: J
authors.lastname: Wang
authors.forename: Lynda
authors.initials: L
authors.lastname: Kong
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Tan
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Li
mesh_terms: D000161:Acoustic Stimulation; D000367:Age Factors; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D058227:Amyloidogenic Proteins / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D020233:Gait Disorders, Neurologic / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007266:Inhibition, Psychological; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic
chemical_list: D016564:Amyloid beta-Protein Precursor; D058227:Amyloidogenic Proteins