title: The mRNA decay pathway regulates the expression of the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae.
abstract: Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
authors.forename: Tricia L
authors.initials: TL
authors.lastname: Lo
authors.forename: Yue
authors.initials: Y
authors.lastname: Qu
authors.forename: Nathalie
authors.initials: N
authors.lastname: Uwamahoro
authors.forename: Tara
authors.initials: T
authors.lastname: Quenault
authors.forename: Traude H
authors.initials: TH
authors.lastname: Beilharz
authors.forename: Ana
authors.initials: A
authors.lastname: Traven
mesh_terms: D018441:Biofilms; D002448:Cell Adhesion / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D020871:RNA Stability; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C110690:FLO11 protein, S cerevisiae; D008562:Membrane Glycoproteins; C117881:NRG1 protein, S cerevisiae; C435344:Nrg2 protein, S cerevisiae; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins