title: Enantioselective Friedel-Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme.
abstract: A human telomeric G-quadruplex (G4DNA) metalloenzyme, assembled with G4DNA and Cu(2+) ions, can catalyze the enantioselective Friedel-Crafts (F-C) reaction in water with good enantioselectivity (up to 75% ee). Furthermore, we found that the absolute configuration and the enantioselectivity of the product largely depend on the conformation and the sequence of G4DNA.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Changhao
authors.initials: C
authors.lastname: Wang
authors.forename: Yinghao
authors.initials: Y
authors.lastname: Li
authors.forename: Guoqing
authors.initials: G
authors.lastname: Jia
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Shengmei
authors.initials: S
authors.lastname: Lu
authors.forename: Can
authors.initials: C
authors.lastname: Li
mesh_terms: D055162:Biocatalysis; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D054856:G-Quadruplexes; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry / Q000378:metabolism*; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D007211:Indoles; D008667:Metalloproteins; D014867:Water; D003300:Copper