title: The path from art to evidence in treating critical limb ischaemia--reflections on 35 years' experience.
abstract: Despite numerous attempts, chronic critical limb ischaemia (CLI) has not been unequivocally defined as yet. Its epidemiology is poorly investigated and its prevalence probably higher than anticipated. It is accompanied by high mortality and morbidity irrespective of the way it is treated. Its management is very expensive. Additionally, the prevailing diabetes epidemic is increasing the need for revascularizations although there is a clear lack of evidence as to when to revascularize an ulcerated diabetic foot. The fast development of endovascular techniques blurs the vision as the window of opportunity for gathering proper evidence keeps narrowing. The notion of endovascular artistry prevails, but attempts to conduct proper studies with clear definitions, strict criteria and appropriate outcome measures in a standardised manner should continue--preferably using propensity scoring if randomised controlled trials are not possible. This review highlights some of the steps leading from art to evidence and illustrates the difficulties encountered along the path. In parallel with this overview, the progress of the treatment for CLI in Finland is described from the perspective of the work concluded at Helsinki University Central Hospital.
authors.affiliation: Department of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland. mauri.lepantalo@hus.fi
authors.forename: M
authors.initials: M
authors.lastname: Lepäntalo
mesh_terms: D002908:Chronic Disease; D017719:Diabetic Foot / Q000266:history / Q000601:surgery; D057510:Endovascular Procedures / Q000266:history*; D019317:Evidence-Based Medicine / Q000266:history; D005387:Finland; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007511:Ischemia / Q000266:history* / Q000601:surgery; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D023821:Limb Salvage / Q000266:history; D016491:Peripheral Vascular Diseases / Q000266:history* / Q000601:surgery; D017410:Practice Guidelines as Topic