title: Review of the novelties presented at the 27th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (I).
abstract: The new insights presented at the 5th Joint Triennial Congress of the European and Americas Committees on Treatment and Research in Multiple Sclerosis (ECTRIMS and ACTRIMS) held in Amsterdam, the Netherlands, 19-22 October 2011, have been summarized at the fourth edition of Post-ECTRIMS meeting held in Madrid in November 2011. Further evidence from epidemiological studies yield a possible relationship between nutrition and alterations of the microbiota that may result in the development of multiple sclerosis (MS) and that may trigger the exacerbation of disease symptoms. Also show the magnitude of impact of comorbidities in multiple sclerosis course as well as the impact of early identification and management. Review of current data on chronic cerebrospinal venous insufficiency and MS sclerosis concludes that there is no role of chronic cerebrospinal venous insufficiency in either multiple sclerosis risk or MS severity. New diagnostic criteria for MS have simplified requirements for demonstrating dissemination of lesions in time. High-field magnetic resonance imaging improves cortical visualization and become a promising tool to detect remyelinization and cortical and medullary lesions, and optical coherence tomography is established as a powerful tool for neuroprotection trials. Diffuse meningeal inflammation through B-cell follicle-like structures is associated with cortical pathology and an accelerated clinical course in secondary progressive MS sclerosis. Systemic inflammation may contribute to neurodegeneration processes in MS, and with regard to grey matter damage recent findings conclude that occurs early in disease course, and correlates with future MS-related disability.
authors.affiliation: Hospital Regional Universitario Carlos Haya, Málaga, España. oscar.fernandez.sspa@juntadeandalucia.es
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Fernández
authors.forename: José C
authors.initials: JC
authors.lastname: Álvarez-Cermeño
authors.forename: Rafael
authors.initials: R
authors.lastname: Arroyo-González
authors.forename: Lluís
authors.initials: L
authors.lastname: Brieva
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Calles-Hernández
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Casanova-Estruch
authors.forename: Manuel
authors.initials: M
authors.lastname: Comabella
authors.forename: Virginia
authors.initials: V
authors.lastname: de las Heras
authors.forename: Juan A
authors.initials: JA
authors.lastname: García-Merino
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Hernández-Pérez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Izquierdo
authors.forename: José E
authors.initials: JE
authors.lastname: Meca-Lallana
authors.forename: Delicias
authors.initials: D
authors.lastname: Muñoz-García
authors.forename: Javier
authors.initials: J
authors.lastname: Olascoaga
authors.forename: Celia
authors.initials: C
authors.lastname: Oreja-Guevara
authors.forename: José M
authors.initials: JM
authors.lastname: Prieto
authors.forename: Lluís
authors.initials: L
authors.lastname: Ramió-Torrentà
authors.forename: Alfredo
authors.initials: A
authors.lastname: Rodríguez-Antigüedad
authors.forename: Lucía
authors.initials: L
authors.lastname: Romero-Pinel
authors.forename: Fernando
authors.initials: F
authors.lastname: Sanchez
authors.forename: Nieves
authors.initials: N
authors.lastname: Téllez
authors.forename: Mar
authors.initials: M
authors.lastname: Tintoré
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
mesh_terms: D035843:Biomedical Research; D003226:Congresses as Topic; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000628:therapy*