title: Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance.
abstract: Clostridium difficile infection (CDI) has become one of the most prevalent and costly nosocomial infections. In spite of the importance of CDI, our knowledge of the pathogenesis of this infection is still rudimentary. Although previous use of antibiotics is generally considered to be the sine qua non of CDI, the mechanisms by which antibiotics render the host susceptible to C. difficile are not well defined. In this review, we will explore what is known about how the indigenous microbiota acts in concert with the host to prevent colonization and virulence of C. difficile and how antibiotic administration disturbs host-microbiota homeostasis, leading to CDI.
authors.affiliation: Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Britton
authors.forename: Vincent B
authors.initials: VB
authors.lastname: Young
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000139:chemically induced* / Q000382:microbiology; D003428:Cross Infection / Q000139:chemically induced / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D054892:Metagenome / Q000187:drug effects*; D056265:Microbial Interactions
chemical_list: D000900:Anti-Bacterial Agents