title: Transient focal cerebral ischemia upregulates immunoproteasomal subunits.
abstract: This study was designed to determine whether focal cerebral ischemia alters the expression of the immunoproteasomal (i-proteasomal) subunits. Transient cerebral ischemia significantly increased the expression of the i-proteasomal subunits, 20S β1i (LMP2) and β5i (LMP7) in the parietal cortex and hippocampus. This alteration was associated with a remarkable increase in ubiquitinated proteins. It is likely that the postischemic induction of the i-proteasome plays an important role in coping with the damaged proteins and thus may have an important effect on neuronal survival and death.
authors.affiliation: Division of Basic Biological Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
authors.forename: Lanhai
authors.initials: L
authors.lastname: Lü
authors.forename: Hongmin
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism; D007150:Immunohistochemistry; D020244:Infarction, Middle Cerebral Artery / Q000201:enzymology / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D046988:Proteasome Endopeptidase Complex / Q000276:immunology* / Q000378:metabolism; D021122:Protein Subunits / Q000276:immunology*; D015854:Up-Regulation
chemical_list: D021122:Protein Subunits; C071313:LMP-2 protein; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex