title: In vitro analyses of ethanol activity against Candida albicans biofilms.
abstract: Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI). Ethanol (EtOH) lock therapy has been attempted despite limited data on optimal dose and duration. Concentrations of 35% EtOH or higher for a minimum of 4 h demonstrated a >99% reduction in mature C. albicans biofilm metabolic activity and prevented regrowth. Concentrations of 10% EtOH or higher reduced C. albicans biofilm formation by >99%. Further investigation of EtOH lock therapy for treatment and prevention of C. albicans CR-BSI is warranted.
authors.affiliation: Section of Infectious Diseases, New Mexico Veterans Healthcare System, Albuquerque, New Mexico, USA.
authors.forename: Hallie S
authors.initials: HS
authors.lastname: Rane
authors.forename: Stella M
authors.initials: SM
authors.lastname: Bernardo
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Walraven
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Lee
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology; D057785:Catheters / Q000382:microbiology; D000431:Ethanol / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000891:Anti-Infective Agents, Local; D000431:Ethanol