title: [Experimental early detection of acute mesenteric ischemia with functional MRI (DWI) and parallel imaging].
abstract: OBJECTIVE
  To evaluate the feasibility of diagnosing in statu nascendi mesenteric ischemia using diffusion-weighted imaging (DWI) in a porcine model. All experiments were approved by the animal care committee at the district administration.
  
  
  METHODS
  Mesenteric blood supply was studied in ten healthy female pigs (weight ~50 kg) with artificially induced mesenteric ischemia. In the DSA technique a branch of the superior mesenteric artery was embolized with tissue glue or small particles. DWI was performed using a 1.5 T MR scanner before embolization and 30 and 60 minutes after embolization using a 32-channel receiver coil. ADC maps were calculated for all animals. The findings were correlated to angiographic and autoptic findings. The image quality of DWI was assessed by means of SNR measurements and diagnostic impact by CNR measurements.
  
  
  RESULTS
  Embolization of the mesenteric branches was technically successful in all cases. DWI of the bowel was feasible with the applied sequences. In all animals, DWI displayed distinct cytotoxic edema as the earliest sign of ischemia thirty minutes after induction of ischemia. Furthermore, DWI yielded a distinct reduction in the water diffusion coefficient in all animals. Variance analysis showed good correlation between CNR measurements and infarction areas. Autoptic findings could confirm the detected infarction areas by DWI.
  
  
  CONCLUSIONS
  DWI using parallel imaging techniques is feasible for the early detection of acute mesenteric ischemia. The presented DWI results offer encouraging prospects regarding more rapid disease diagnosis.
authors.affiliation: Klinik für diagnostische und interventionelle Radiologie, HELIOS Klinikum Wuppertal, Klinikum der Privaten Universität Witten/Herdecke, Wuppertal. claudia-alice.schwartz@helioskliniken.de
authors.forename: C A
authors.initials: CA
authors.lastname: Schwartz
authors.forename: P
authors.initials: P
authors.lastname: Haage
authors.forename: C
authors.initials: C
authors.lastname: Hohl
mesh_terms: D000792:Angiography; D000818:Animals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D007238:Infarction / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D065666:Mesenteric Ischemia; D012680:Sensitivity and Specificity; D013552:Swine; D014652:Vascular Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology