title: Bilateral uveitis after phakic intraocular lens implantation and management with adalimumab.
abstract: A 25-year-old woman with myopia who had an AC pIOL implantation in the left eye and posterior chamber pIOL implantation in the right eye developed bilateral granulomatous panuveitis 2 months after the second surgery. Physical examination showed bilateral Koeppe and Busacca nodules. Fluorescein angiography showed diffuse vascular and retinal pigment epithelial leakage in both eyes. With assessment of sympathetic ophthalmia, treatment with a high-dose systemic steroid was started. Oral cyclosporine and azathioprine were later added. Because the uveitis was not controlled, adalimumab was added. After 6 doses of adalimumab (40 mg subcutaneously), the uveitis subsided and corticosteroid and other immunosuppressive agents were tapered. Refractive AC pIOL implantation should be added to the list of intraocular procedures that may induce sympathetic ophthalmia. Adalimumab may have a therapeutic role in its management.
authors.affiliation: Shahid Beheshti Medical University, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soheilian
authors.forename: Mohammadhossein
authors.initials: M
authors.lastname: Jabbarpourbonyadi
authors.forename: Roham
authors.initials: R
authors.lastname: Soheilian
authors.forename: Gholam A
authors.initials: GA
authors.lastname: Peyman
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D047728:Myopia, Degenerative / Q000601:surgery*; D009879:Ophthalmia, Sympathetic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D054120:Phakic Intraocular Lenses; D014792:Visual Acuity
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab