title: Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions.
abstract: Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis.
authors.affiliation: Department of Physiological Chemistry, University of Veterinary Medicine, D-30559 Hannover, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Behrendt
authors.forename: Michael P
authors.initials: MP
authors.lastname: Krahn
authors.forename: Hiam
authors.initials: H
authors.lastname: Al-Bayati
authors.forename: Mahdi
authors.initials: M
authors.lastname: Amiri
authors.forename: Sandra
authors.initials: S
authors.lastname: Rizk
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Naim
mesh_terms: D000818:Animals; D016466:CHO Cells; D015820:Cadherins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002450:Cell Communication; D016764:Cell Polarity; D006224:Cricetinae; D003412:Cricetulus; D003593:Cytoplasm / Q000378:metabolism; D004285:Dogs; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D017434:Protein Structure, Tertiary; D017384:Sequence Deletion
chemical_list: C476579:CDH24 protein, human; D015820:Cadherins