title: Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis.
abstract: BACKGROUND
  Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated.
  
  
  METHODS
  Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen -A (HLA-A) in NPC tissue samples.
  
  
  RESULTS
  The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A.
  
  
  CONCLUSIONS
  Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
authors.forename: Man-Bo
authors.initials: MB
authors.lastname: Cai
authors.forename: Xiao-Pai
authors.initials: XP
authors.lastname: Wang
authors.forename: Jia-Xing
authors.initials: JX
authors.lastname: Zhang
authors.forename: Hui-Qiong
authors.initials: HQ
authors.lastname: Han
authors.forename: Chao-Chun
authors.initials: CC
authors.lastname: Liu
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Bei
authors.forename: Ruo-Jun
authors.initials: RJ
authors.lastname: Peng
authors.forename: Yi
authors.initials: Y
authors.lastname: Liang
authors.forename: Qi-Sheng
authors.initials: QS
authors.lastname: Feng
authors.forename: Hai-Yun
authors.initials: HY
authors.lastname: Wang
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Chen
authors.forename: Sha
authors.initials: S
authors.lastname: Fu
authors.forename: Tiebang
authors.initials: T
authors.lastname: Kang
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Shao
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Zeng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D016019:Survival Analysis; D046888:Tissue Array Analysis
chemical_list: D018840:HSP70 Heat-Shock Proteins