title: [Hypersensitivity to proton pump inhibitors].
abstract: Hypersensitivity to proton pump inhibitors (PPI) is rare but potentially severe. An increase in hypersensitivity reactions to PPI is expected as these drugs are widely prescribed and some have become available over-the-counter. Allergy to PPI has to be considered in patients presenting anaphylaxis, late-type skin rashes, interstitial nephritis and other organ involvement suspicious to be drug-induced. Cross-reactivity between PPI is of concern, as they are closely related in structure. Skin prick- and intradermal testing are reliable tools to confirm immediate-type allergy to one PPI compound and search for safe alternatives. We review the literature on immediate and delayed hypersensitivity to these drugs.
authors.affiliation: Service d'allergologie et immunologie clinique, HUG, 1211 Geneve 14. marcel.bergmann@hcuge.ch
authors.forename: M
authors.initials: M
authors.lastname: Bergmann
authors.forename: B
authors.initials: B
authors.lastname: Guignard
authors.forename: C
authors.initials: C
authors.lastname: Ribi
mesh_terms: D000465:Algorithms; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D015394:Molecular Structure; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000737:chemistry; D012882:Skin Tests
chemical_list: D054328:Proton Pump Inhibitors