title: Association of promoter region single nucleotide polymorphisms at positions -819C/T and -592C/A of interleukin 10 gene with ischemic heart disease.
abstract: OBJECTIVE
  Ischemic heart disease (IHD) is a disease characterized by ischemia of the heart muscle, usually due to coronary artery disease. Interleukin-10 (IL10) is a proinflammatory cytokine known to protect endothelial function. In this study, we investigated the association of promoter region polymorphisms of the IL10 gene with IHD.
  
  
  METHODS
  We recruited 313 control and 173 IHD patients. The selected SNPs in IL10 were genotyped using pyrosequencing.
  
  
  RESULTS
  SNPs at positions -592C/A and -819C/T were statistically associated with IHD (P = 0.014 and P = 0.037). Similarly, the mean value of C-reactive protein in the C allele at -592C/A and -819C/T was significantly higher than that in the A allele at -592C/A (P = 0.026) and T allele at -819C/T (P = 0.026). The presence of hypertension in the C allele at -592C/A and -819C/T was significantly more frequent than that in the A allele at -592C/A (P = 0.044) and T allele at -819C/T (P = 0.044). In the haplotype of two SNPs (-592C/A and -819C/T), one haplotype (CC) presented an association with IHD (P = 0.012).
  
  
  CONCLUSIONS
  These results indicate that the C allele with SNPs at position -592C/A and -819C/T of IL10 gene may be associated with IHD in the Korean population.
authors.affiliation: Department of Biochemistry, School of Medicine, Keimyung University, Dalseo-Gu, Daegu, Korea.
authors.forename: Gyeong-Im
authors.initials: GI
authors.lastname: Yu
authors.forename: Ho-Chan
authors.initials: HC
authors.lastname: Cho
authors.forename: Yun-Kyeong
authors.initials: YK
authors.lastname: Cho
authors.forename: Hyoung-Seob
authors.initials: HS
authors.lastname: Park
authors.forename: Hyuck-Jun
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Hyung-Seop
authors.initials: HS
authors.lastname: Kim
authors.forename: Chang-Wook
authors.initials: CW
authors.lastname: Nam
authors.forename: Yoon-Nyun
authors.initials: YN
authors.lastname: Kim
authors.forename: Kwon-Bae
authors.initials: KB
authors.lastname: Kim
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Ha
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Hur
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D016753:Interleukin-10