title: A broad assessment of clinical outcomes after laparoscopic antireflux surgery.
abstract: OBJECTIVE
  There is considerable discussion regarding "success" rates for laparoscopic antireflux surgery (LARS). We hypothesized that, in part, this was a reflection of the outcome variables used. We, therefore, defined 8 specific variables (within 3 categories) and assessed outcomes for each in a large cohort of patients.
  
  
  METHODS
  Four hundred patients (208 women; median age 52 years old) who underwent LARS at the University of Washington from 1993 to 2008 were given a comprehensive questionnaire to assess various aspects of their outcomes from LARS. In addition, we analyzed all functional studies and all endoscopies performed in these patients in our institution, whether the patients had symptoms or not, and compared the findings to all available preoperative values.
  
  
  RESULTS
  The median follow-up was 92 (6-175) months.
  
  
  CONCLUSIONS
  The success or failure of LARS cannot be defined in a single domain. A comprehensive analysis of outcomes requires categorization that includes symptom response, side-effects, patient's perception and objective measurement of acid exposure, mucosal integrity, and the need for additional medical or surgical treatment. Only then can patients and physicians better understand the role of LARS and make informed decisions.
authors.affiliation: Department of Surgery, University of Washington, Seattle WA 98195, USA. brant@u.washington.edu
authors.forename: Brant K
authors.initials: BK
authors.lastname: Oelschlager
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Ma
authors.forename: Renato V
authors.initials: RV
authors.lastname: Soares
authors.forename: Martin I
authors.initials: MI
authors.lastname: Montenovo
authors.forename: Juan E
authors.initials: JE
authors.lastname: Munoz Oca
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pellegrini
mesh_terms: D001471:Barrett Esophagus / Q000150:complications; D003131:Combined Modality Therapy; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012086:Reoperation; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors