title: Review analysis of the association between the prevalence of activated brown adipose tissue and outdoor temperature.
abstract: Brown adipose tissue (BAT) is important for regulating body weight. Environmental temperature influences BAT activation. Activated BAT is identifiable using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT). (18)F-FDG PET/CT scans done between June 2005 and May 2009 in our institution in tropical southern Taiwan and BAT studies from PubMed (2002-2011) were reviewed, and the average outdoor temperatures during the study periods were obtained. A simple linear regression was used to analyze the association between the prevalence of activated BAT (P) and the average outdoor temperature (T). The review analysis for 9 BAT studies (n = 16, 765) showed a significant negative correlation (r = -0.741, P = 0.022) between the prevalence of activated BAT and the average outdoor temperature. The equation of the regression line is P(%) = 6.99 - 0.20 × T (°C). The prevalence of activated BAT decreased by 1% for each 5°C increase in average outdoor temperature. In a neutral ambient temperature, the prevalence of activated BAT is low and especially rare in the tropics. There is a significant linear negative correlation between the prevalence of activated BAT and the average outdoor temperature.
authors.affiliation: Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Yung-Cheng
authors.initials: YC
authors.lastname: Huang
authors.forename: Chien-Chin
authors.initials: CC
authors.lastname: Hsu
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Wang
authors.forename: Yen-Hsiang
authors.initials: YH
authors.lastname: Chang
authors.forename: Tai-Been
authors.initials: TB
authors.lastname: Chen
authors.forename: Bi-Fang
authors.initials: BF
authors.lastname: Lee
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016014:Linear Models; D064847:Multimodal Imaging / Q000379:methods; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism; D049268:Positron-Emission Tomography; D015995:Prevalence; D012196:Review Literature as Topic; D013624:Taiwan / Q000453:epidemiology; D013696:Temperature; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18