title: ALK-mutated non-small-cell lung cancer: a new strategy for cancer treatment.
abstract: The anaplastic lymphoma kinase (ALK) tyrosine kinase (TK) receptor has emerged recently as a potentially relevant biomarker and therapeutic target in solid and hematologic tumors. A variety of alterations in the ALK gene, such as mutations, overexpression, amplification, translocations, or other structural rearrangements, have been implicated in human cancer tumorigenesis. In this article we review the potential role that ALK may have in lung tumor origin, the methodology to detect the different molecular alterations, and the most important clinical aspects of ALK alterations in NSCLC patients.
authors.affiliation: Department of Medical Oncology, Hospital de Torrejón, 28850 Torrejón de Ardoz, Madrid, Spain. lcabezon@torrejonsalud.com
authors.forename: Luis
authors.initials: L
authors.lastname: Cabezón-Gutiérrez
authors.forename: Parham
authors.initials: P
authors.lastname: Khosravi-Shahi
authors.forename: Victor Manuel
authors.initials: VM
authors.lastname: Diaz-Muñoz-de-la-Espada
authors.forename: Jose Rafael
authors.initials: JR
authors.lastname: Carrión-Galindo
authors.forename: Itziar
authors.initials: I
authors.lastname: Eraña-Tomás
authors.forename: María
authors.initials: M
authors.lastname: Castro-Otero
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics*; D000077547:Crizotinib; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases