title: Aminocatalytic enantioselective 1,6 additions of alkyl thiols to cyclic dienones: vinylogous iminium ion activation.
abstract: Remote transmission: In the presence of chiral amines, 2,4-dienones are activated toward the attack of a nucleophile at the δ position, a mode of activation that is termed vinylogous iminium ion catalysis. Specifically, the 1,6 addition of alkyl thiols to β-substituted cyclic dienones was catalyzed by a cinchona-based primary amine; the reaction was highly stereoselective and displayed high selectivity for reaction at the δ position.
authors.affiliation: ICIQ-Institute of Chemical Research of Catalonia, Avenida Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Xu
authors.initials: X
authors.lastname: Tian
authors.forename: Yankai
authors.initials: Y
authors.lastname: Liu
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre