title: Hole transfer in LNA and 5-Me-2'-deoxyzebularine-modified DNA.
abstract: We report the measurement of hole-transfer rate constants (k(ht)) in locked nucleic acid (LNA) and 5-Me-2'-deoxyzebularine (B)-modified DNA. LNA modification, which makes DNA more rigid, caused a decrease of more than 2 orders of magnitude in k(ht), whereas B modification, which increases DNA flexibility, increased k(ht) by more than 20-fold. The present results clearly showed that hole-transfer efficiency in DNA can be increased by increasing DNA flexibility.
authors.affiliation: The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Japan. kiyohiko@sanken.osaka-u.ac.jp
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kawai
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Hayashi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Majima
mesh_terms: D003562:Cytidine / Q000031:analogs & derivatives* / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D010782:Photolysis; D016062:Porosity; D013499:Surface Properties; D044366:Transition Temperature
chemical_list: C575679:5-methyl-2'-deoxyzebularine; D009841:Oligonucleotides; C477371:locked nucleic acid; D003562:Cytidine; D004247:DNA