title: Analytical methods for characterizing magnetic resonance probes.
abstract: The efficiency of Gd(III) contrast agents in magnetic resonance image enhancement is governed by a set of tunable structural parameters. Understanding and measuring these parameters requires specific analytical techniques. This Feature describes strategies to optimize each of the critical Gd(III) relaxation parameters for molecular imaging applications and the methods employed for their evaluation.
authors.affiliation: Department of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois 60208-3113, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Manus
authors.forename: Renee C
authors.initials: RC
authors.lastname: Strauch
authors.forename: Andy H
authors.initials: AH
authors.lastname: Hung
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Eckermann
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Meade
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D014867:Water; D005682:Gadolinium