title: Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization.
abstract: A novel protocol for nickel-catalyzed direct sp(2) C-H bond alkylation of N-aromatic heterocycles has been developed. This new reaction proceeded efficiently at room temperature using a Grignard reagent as the coupling partner. This approach provides new access to a variety of alkylated N-aromatic heterocycles which are potentially of great importance in medicinal chemistry.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China.
authors.forename: Peng-Yang
authors.initials: PY
authors.lastname: Xin
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Ding
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
mesh_terms: D000478:Alkylation; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D009532:Nickel