title: Catalyst development for organocatalytic hydrosilylation of aromatic ketones and ketimines.
abstract: A new family of Lewis basic 2-pyridyl oxazolines have been developed, which can act as efficient organocatalysts for the enantioselective reduction of prochiral aromatic ketones and ketimines with trichlorosilane, a readily available and inexpensive reagent. 1-Isoquinolyl oxazoline, derived from mandelic acid, was identified as the most efficient catalyst of the series, capable of delivering high enantioselectivities in the reduction of both ketones (up to 94% ee) and ketimines (up to 89% ee).
authors.affiliation: Department of Chemistry, WestChem, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Angus J P
authors.initials: AJ
authors.lastname: Stewart-Liddon
authors.forename: Grant D
authors.initials: GD
authors.lastname: McGeoch
authors.forename: Pedro
authors.initials: P
authors.lastname: Ramírez-López
authors.forename: Pavel
authors.initials: P
authors.lastname: Kočovský