title: 1Hz rTMS preconditioned by tDCS over the primary motor cortex in Parkinson's disease: absence of effect on arm lift and hand grip force control.
abstract: This study investigated whether a period of low frequency rTMS preconditioned by tDCS over the primary motor cortex modulates control of grip force in Parkinson's disease. The presented results are from the same patient cohort tested in an earlier study (Gruner et al. J Neural Transm 2010: 117: 207-216). 15 patients with Parkinson's disease (mean age: 69 ± 8 years; average disease duration: 5 ± 3 years) on dopaminergic drugs performed a grasp-lift task with either hand before (baseline) and after a period of 1Hz rTMS (90% of the resting motor threshold; 900 pulses) preconditioned by sham, anodal or cathodal tDCS (1mA, 10 min) over the primary motor cortex. We found that compared with baseline, none of the grip force parameters was significantly influenced by either stimulation session and concluded that grasping is a higher order motor skill, which cannot be modulated by tDCS preconditioned 1Hz rTMS in PD.
authors.affiliation: Department of Neurology, University of Cologne, Cologne, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Eggers
authors.forename: Ulrike
authors.initials: U
authors.lastname: Grüner
authors.forename: Mitra
authors.initials: M
authors.lastname: Ameli
authors.forename: Anna-Sophia
authors.initials: AS
authors.lastname: Sarfeld
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Nowak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004599:Electric Stimulation Therapy; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation