title: Scopararanes C-G: new oxygenated pimarane diterpenes from the marine sediment-derived fungus Eutypella scoparia FS26.
abstract: Five new oxygenated pimarane diterpenes, named scopararanes C-G (1-5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1-5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1-5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.
authors.affiliation: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.|College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.
authors.forename: Dongli
authors.initials: D
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Tao
authors.affiliation: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.
authors.forename: Yuchan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Feijun
authors.initials: F
authors.lastname: Dan
authors.affiliation: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Provincial Open Laboratory of Applied Microbiology, State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base), South China, Guangdong Institute of Microbiology, Guangzhou 510070, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D045784:Abietanes / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004396:Coloring Agents; D003470:Culture Media / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012623:Seawater / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013778:Tetrazolium Salts; D013844:Thiazoles; D013098:Xylariales / Q000378:metabolism*
chemical_list: D045784:Abietanes; D000903:Antibiotics, Antineoplastic; D004396:Coloring Agents; D003470:Culture Media; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue