title: [Exogenous 3', 5'-cyclic diguanylic acid prevents caries formation in rats].
abstract: OBJECTIVE
  To investigate the effect of exogenous c-di-GMP in preventing dental caries formation in SD rats.
  
  
  METHODS
  Twenty-day-old SD rats with dental caries induced by S. Mutans infection were randomly divided into 3 groups for treatment with dental application of exogenous c-di-GMP, NaF solution or 0.9% NaCl, and changes in the bacterial number and scores of dental caries following the treatments were recorded.
  
  
  RESULTS
  Compared with 0.9% NaCl treatment, exogenous c-di-GMP treatment significantly lowered the scores of dental caries on the occlusal surface and smooth surface (P<0.05) but produced no obvious effect on the number of bacterial plagues (P>0.05).
  
  
  CONCLUSIONS
  Exogenous c-di-GMP can be a novel agent for prevention and treatment of tooth decay.
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ywj918@sohu.com
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Yan
authors.forename: Dehong
authors.initials: D
authors.lastname: Yang
authors.forename: Buling
authors.initials: B
authors.lastname: Wu
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D013295:Streptococcus mutans
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP