title: The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis.
abstract: Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.
authors.affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Liu
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Su
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Schmid
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry; D002966:Clathrin / Q000737:chemistry*; D034281:Dynamins / Q000737:chemistry* / Q000145:classification; D004705:Endocytosis; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000737:chemistry; D009928:Organ Specificity; D010750:Phosphoproteins / Q000737:chemistry; D010802:Phylogeny; D020033:Protein Isoforms / Q000737:chemistry; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
chemical_list: D001798:Blood Proteins; D002966:Clathrin; D010750:Phosphoproteins; D020033:Protein Isoforms; C039077:platelet protein P47; D034281:Dynamins