title: Wasting is associated with stunting in early childhood.
abstract: The longitudinal relationship between stunting and wasting in children is poorly characterized. Instances of wasting or poor weight gain may precede linear growth retardation. We analyzed longitudinal anthropometric data for 1599 children from 8 cohort studies to determine the effect of wasting [weight-for-length Z-score (WLZ) < -2] and variability in WLZ in the first 17 mo on length-for-age Z-score (LAZ) at 18-24 mo of age. In addition, we considered the effects of change in WLZ during the previous 6-mo period on length at 18 and 24 mo. Wasting at 6-11 or 12-17 mo was associated with decreased LAZ; however, children who experienced wasting only at 0-5 mo did not suffer any long-term growth deficits compared with children with no wasting during any period. Children with greater WLZ variability (≥0.5 SD) in the first 17 mo of life were shorter [LAZ = -0.51 SD (95% CI: -0.67, -0.36 SD)] at 18-24 mo of age than children with WLZ variability <0.5. Change in WLZ in the previous 6-mo period was directly associated with greater attained length at 18 mo [0.33 cm (95% CI: 0.11, 0.54 cm)] and 24 mo [0.72 cm (95% CI: 0.52, 0.92 cm)]. Children with wasting, highly variable WLZ, or negative changes in WLZ are at a higher risk for linear growth retardation, although instances of wasting may not be the primary cause of stunting in developing countries.
authors.affiliation: Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Richard
authors.forename: Robert E
authors.initials: RE
authors.lastname: Black
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Richard L
authors.initials: RL
authors.lastname: Guerrant
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kang
authors.forename: Claudio F
authors.initials: CF
authors.lastname: Lanata
authors.forename: Kåre
authors.initials: K
authors.lastname: Mølbak
authors.forename: Zeba A
authors.initials: ZA
authors.lastname: Rasmussen
authors.forename: R Bradley
authors.initials: RB
authors.lastname: Sack
authors.forename: Palle
authors.initials: P
authors.lastname: Valentiner-Branth
authors.forename: William
authors.initials: W
authors.lastname: Checkley
mesh_terms: D000886:Anthropometry; D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D003906:Developing Countries; D005260:Female; D006128:Growth; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D019282:Wasting Syndrome / Q000150:complications*