title: Plerixafor use in patients with previous mobilization failure: A multicenter experience.
abstract: Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2×10(6)/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure.
authors.affiliation: Ankara Oncology Education and Research Hospital, Hematology and Stem Cell Transplantation Clinic, Demetevler-Yenimahalle, 06200 Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Tekgündüz
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntaş
authors.forename: Serdar
authors.initials: S
authors.lastname: Sıvgın
authors.forename: Sahika Zeynep
authors.initials: SZ
authors.lastname: Akı
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dönmez
authors.forename: Pervin
authors.initials: P
authors.lastname: Topçuoğlu
authors.forename: Rahşan
authors.initials: R
authors.lastname: Yıldırım
authors.forename: Nuran Ahu
authors.initials: NA
authors.lastname: Baysal
authors.forename: Erol
authors.initials: E
authors.lastname: Ayyıldız
authors.forename: Meltem Kurt
authors.initials: MK
authors.lastname: Yüksel
authors.forename: Ismail
authors.initials: I
authors.lastname: Sarı
authors.forename: Murat
authors.initials: M
authors.lastname: Tombuloğlu
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
authors.forename: Osman
authors.initials: O
authors.lastname: Ilhan
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D001596:Benzylamines; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D007958:Leukocyte Count; D008223:Lymphoma / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous
chemical_list: D019380:Anti-HIV Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor