title: The synthesis of a novel chalcone and evaluation for anti-free radical activity and antagonizing the learning impairments in Alzheimer's model.
abstract: We synthesized a new chalcone (4,2'-dihydroxy-3methoxy-5-bromine chalcone; C) and structurally identified it via infrared spectrometry (IR), (1)H-NMR, mass spectrometry (MS) and element analysis (EA). C was confirmed to be highly potent in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Tests of anti-free radical activity in response to oxidative stress in mice revealed that C could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in a free-radical-injured scopolamine-induced Alzheimer's model. Further behavioral tests with the Morris water maze showed that C could antagonize the learning impairments in the Alzheimer's model, which suggests that C has a potential role in Alzheimer's disease.
authors.affiliation: Department of Chemistry, Shantou University Medical College, Shantou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.forename: Yicun
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yu
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Wang
authors.forename: Lumian
authors.initials: L
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jinhong
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005980:Glutathione Reductase / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007859:Learning Disabilities / Q000201:enzymology / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000378:metabolism; D013058:Mass Spectrometry; D018782:Maze Learning; D051379:Mice; D018384:Oxidative Stress; D013055:Spectrophotometry, Infrared; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: C576155:4,2'-dihydroxy-3-methoxy-5-bromine chalcone; D047188:Chalcones; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase