title: Vulvar skin atrophy induced by topical glucocorticoids.
abstract: Steroid-induced skin atrophy is the most frequent and perhaps most important cutaneous side effect of topical glucocorticoid therapy. To date, it has not been described in vulvar skin. A patient presented with significant vulvar skin atrophy following prolonged steroid application to treat vulvar dermatitis. The extensive atrophy in the perineum resulted in secondary "webbing" and partial obstruction of the genital hiatus and superimposed dyspareunia. Prolonged use of topical steroids may result in atrophic changes in vulvar skin. Further research in clinical correlates of steroid-induced atrophy in the vulvar region is warranted.
authors.affiliation: University of North Carolina at Chapel Hill, Department ofObstetrics and Gynecology, 27599, USA. edinkins@med.unc.edu
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Johnson
authors.forename: Pamela
authors.initials: P
authors.lastname: Groben
authors.forename: Alisa
authors.initials: A
authors.lastname: Eanes
authors.forename: Priya
authors.initials: P
authors.lastname: Iyer
authors.forename: Joseph
authors.initials: J
authors.lastname: Ugoeke
authors.forename: Denniz
authors.initials: D
authors.lastname: Zolnoun
mesh_terms: D000279:Administration, Cutaneous; D001284:Atrophy / Q000139:chemically induced; D003876:Dermatitis, Atopic / Q000188:drug therapy; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D014844:Vulva / Q000473:pathology*; D014845:Vulvar Diseases / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D004967:Estrogens; D005938:Glucocorticoids