title: Approach-avoidance processes contribute to dissociable impacts of risk and loss on choice.
abstract: Value-based choices are influenced both by risk in potential outcomes and by whether outcomes reflect potential gains or losses. These variables are held to be related in a specific fashion, manifest in risk aversion for gains and risk seeking for losses. Instead, we hypothesized that there are independent impacts of risk and loss on choice such that, depending on context, subjects can show either risk aversion for gains and risk seeking for losses or the exact opposite. We demonstrate this independence in a gambling task, by selectively reversing a loss-induced effect (causing more gambling for gains than losses and the reverse) while leaving risk aversion unaffected. Consistent with these dissociable behavioral impacts of risk and loss, fMRI data revealed dissociable neural correlates of these variables, with parietal cortex tracking risk and orbitofrontal cortex and striatum tracking loss. Based on our neural data, we hypothesized that risk and loss influence action selection through approach-avoidance mechanisms, a hypothesis supported in an experiment in which we show valence and risk-dependent reaction time effects in line with this putative mechanism. We suggest that in the choice process risk and loss can independently engage approach-avoidance mechanisms. This can provide a novel explanation for how risk influences action selection and explains both classically described choice behavior as well as behavioral patterns not predicted by existing theory.
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom. n.wright@fil.ion.ucl.ac.uk
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Wright
authors.forename: Mkael
authors.initials: M
authors.lastname: Symmonds
authors.forename: Karen
authors.initials: K
authors.lastname: Hodgson
authors.forename: Thomas H B
authors.initials: TH
authors.lastname: Fitzgerald
authors.forename: Bonni
authors.initials: B
authors.lastname: Crawford
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001931:Brain Mapping / Q000379:methods / Q000523:psychology*; D002540:Cerebral Cortex / Q000502:physiology; D002755:Choice Behavior; D003342:Corpus Striatum / Q000502:physiology; D005260:Female; D005715:Gambling / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000523:psychology; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D008960:Models, Psychological; D011930:Reaction Time / Q000502:physiology; D012309:Risk-Taking