title: Fluticasone furoate nasal spray reduces symptoms of  uncomplicated acute rhinosinusitis: a randomised  placebo-controlled study.
abstract: BACKGROUND
  Uncomplicated acute rhinosinusitis (ARS) is usually a self-limiting inflammatory condition often treated with antibiotics.
  
  
  OBJECTIVE
  To assess the safety and efficacy of fluticasone furoate nasal spray (FFNS) compared with placebo for symptomatic relief of uncomplicated ARS.
  
  
  METHODS
  A randomised, double-blind, placebo-controlled, parallel-group, multicentre, 2-week treatment study of FFNS 110 μg once and twice daily was undertaken in adults/adolescents.
  
  
  RESULTS
  A statistically significant reduction was seen in the daily major symptoms score, a composite score of three individual symptoms (nasal congestion/stuffiness, sinus headache/pressure or facial pain/pressure, and postnasal drip on a 0-3 scale) by both FFNS doses compared with placebo (least square mean differences vs. placebo of -0.386 (p=0.008) and -0.357 (p=0.014) for once daily and twice daily FFNS, respectively). The differences in median times to symptom improvement were not statistically significant between each dose of FFNS (7 days) and placebo (8 days). There were no treatment differences in antibiotic use for possible fulminant bacterial rhinosinusitis (3% in each group). The safety profile of FFNS was similar to placebo.
  
  
  CONCLUSIONS
  FFNS reduces symptoms of uncomplicated ARS compared with placebo and is well tolerated, providing support for withholding antibiotics in selected patients.
authors.affiliation: McMaster University, Hamilton, Ontario, Canada.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Keith
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dymek
authors.forename: Oliver
authors.initials: O
authors.lastname: Pfaar
authors.forename: Wytske
authors.initials: W
authors.lastname: Fokkens
authors.forename: Suyong
authors.initials: S
authors.lastname: Yun Kirby
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Cindy
authors.initials: C
authors.lastname: Garris
authors.forename: Nazli
authors.initials: N
authors.lastname: Topors
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D059085:Nasal Sprays; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D000730:Androstadienes; D059085:Nasal Sprays; C523187:fluticasone furoate