title: Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome.
abstract: OBJECTIVE
  To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis.
  
  
  METHODS
  Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed.
  
  
  RESULTS
  Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively).
  
  
  CONCLUSIONS
  Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.
authors.affiliation: Department of Neurology and Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. anaclarapjardim@gmail.com
authors.forename: Anaclara Prada
authors.initials: AP
authors.lastname: Jardim
authors.forename: Rafael Scarpa da Costa
authors.initials: RS
authors.lastname: Neves
authors.forename: Luís Otávio Sales Ferreira
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Carmen Lucia Penteado
authors.initials: CL
authors.lastname: Lancellotti
authors.forename: Murilo Martinez
authors.initials: MM
authors.lastname: Marinho
authors.forename: Ricardo Silva
authors.initials: RS
authors.lastname: Centeno
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Carla Alessandra
authors.initials: CA
authors.lastname: Scorza
authors.forename: Elza Márcia Targas
authors.initials: EM
authors.lastname: Yacubian
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy; D002452:Cell Count; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009474:Neurons / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012598:Sclerosis; D013702:Temporal Lobe / Q000473:pathology*; D016896:Treatment Outcome