title: Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter".
abstract: Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT-116) cells with IC(50) values of 0.11 μM.
authors.affiliation: Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany.
authors.forename: Alberto
authors.initials: A
authors.lastname: Plaza
authors.forename: Ronald
authors.initials: R
authors.lastname: Garcia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
authors.forename: Javier Pablo
authors.initials: JP
authors.lastname: Martinez
authors.forename: Stephan
authors.initials: S
authors.lastname: Hüttel
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyerhans
authors.forename: Marc
authors.initials: M
authors.lastname: Stadler
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D047630:Depsipeptides; C574677:aetheramide A; C574678:aetheramide B