title: Analgesic effect of magnetic stimulation on paclitaxel-induced peripheral neuropathic pain in mice.
abstract: Peripheral neuropathies are common side effects of chemotherapeutic drugs, including taxanes, platinum-based drugs, vinca alkaloids, and thalidomide. The most common symptoms are numbness, tingling and/or burning pain in a stocking-glove distribution. Severe peripheral neuropathies result in dose reductions, a change in chemotherapy regimen, or early cessation of chemotherapy. There are no proven interventions to prevent or treat chemotherapy-induced peripheral neuropathy. We designed and built a unique magnetic stimulator to clarify the effects of magnetic stimulation in the mouse paclitaxel-induced peripheral neuropathic pain model. Magnetic stimulation significantly reversed paclitaxel-induced mechanical hyperalgesia. The analgesic efficacy of magnetic stimulation was inhibited by naloxone, a μ opioid receptor antagonist. These findings indicate that the analgesic effect of magnetic stimulation is likely to be mediated by the endogenous opioid system. Furthermore, a combination of magnetic stimulation and pregabalin, a Ca(2+) channel blocker, induced a potent combinational analgesic effect, suggesting that analgesic drug dose reduction might be possible. These findings indicate that there is a potential therapeutic utility for magnetic stimulation in pain relief.
authors.affiliation: R&D Center, Terumo Co., 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan. Nozomi_Ami@terumo.co.jp
authors.forename: Nozomi
authors.initials: N
authors.lastname: Ami
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Oshima
mesh_terms: D000698:Analgesia / Q000379:methods*; D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D006930:Hyperalgesia / Q000139:chemically induced / Q000628:therapy; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009437:Neuralgia / Q000139:chemically induced* / Q000628:therapy*; D017239:Paclitaxel / Q000633:toxicity*; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D000700:Analgesics; D017239:Paclitaxel