title: Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence.
abstract: BACKGROUND
  Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD).
  
  
  METHODS
  Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n = 189) were enrolled. Subjects with coronary artery stenosis (≥ 75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n = 96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (< 75%) (n = 67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD.
  
  
  RESULTS
  Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9 ± 2·4 vs. 6·9 ± 2·6 μg/mL, P < 0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (> 4·34 μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels.
  
  
  CONCLUSIONS
  Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.
authors.affiliation: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. masuda@imed2.med.osaka-u.ac.jp
authors.forename: Daisaku
authors.initials: D
authors.lastname: Masuda
authors.forename: Taizo
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tsujii
authors.forename: Miwako
authors.initials: M
authors.lastname: Inagaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakatani
authors.forename: Miyako
authors.initials: M
authors.lastname: Yuasa-Kawase
authors.forename: Kazumi
authors.initials: K
authors.lastname: Tsubakio-Yamamoto
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohama
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishida
authors.forename: Masato
authors.initials: M
authors.lastname: Ishigami
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Akifumi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Naohiko
authors.initials: N
authors.lastname: Sakai
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Shizuya
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D053283:Apolipoprotein B-48 / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology; D005215:Fasting; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015995:Prevalence; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D053283:Apolipoprotein B-48; D008055:Lipids