title: Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin.
abstract: Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3'RR/Cdk4(R24C) mice and c-myc-3'RR/p53+/- mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4(R24C) mutation or p53 mutations). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/ p53+/- mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity.
authors.affiliation: UMR CNRS 7276, Faculté de Médecine, Limoges, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Rouaud
authors.forename: Rémi
authors.initials: R
authors.lastname: Fiancette
authors.forename: Christelle
authors.initials: C
authors.lastname: Vincent-Fabert
authors.forename: Virginie
authors.initials: V
authors.lastname: Magnone
authors.forename: Michel
authors.initials: M
authors.lastname: Cogné
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
authors.forename: Yves
authors.initials: Y
authors.lastname: Denizot
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics*; D020869:Gene Expression Profiling; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D009154:Mutation / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; C495902:Cdk4 protein, mouse; D051358:Cyclin-Dependent Kinase 4