title: [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population].
abstract: OBJECTIVE
  To investigate the association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of pulmonary cancer in Henan population.
  
  
  METHODS
  A case-control study of 209 lung cancer patients and 256 healthy control subjects was conducted in Henan population to investigate the role of CYP1A1-Msp1, CYP1A1-exon7, GSTM1, GSTT1, mEH-exon3, mEH-exon4 and XRCC1 in lung cancer. Genotyping was performed by using PCR based restriction fragment length polymorhphism techniques.
  
  
  RESULTS
  The frequency of GSTM1-null, CYP1A1-exon7 mt/mt, mEH-exon3 mt/mt, XRCC1-194 Trp/Trp, XRCC1-280 His/His genotype in the lung cancer case group was significantly higher than that in control group (P < 0.05). The risk of lung cancer was higher in individuals carrying genotypes of GSTM1 (ORadj = 1.76, 95% CI 1.21-2.56, P = 0.005), CYP1A1-exon7 Ile/val + val/val (ORadj = 1.65, 95% CI 1.16-2.39, P = 0.009), mEH-exon3 wt/mt + mt/mt (ORadj = 1.77, 95% CI 1.18-2.64, P = 0.007), XRCC1-194 Arg/Trp + Trp/Trp (ORadj = 1.55, 95% CI 1.07-2.27, P = 0.016) and XRCC1-280 His/His (ORadj = 2.21, 95% CI 1.05-4.52, P = 0.026) than those carrying genotypes of GSTM1 null, CYP1A1-exon7 Ile/Ile, mEH-exon3 wt/wt, XRCC1-194 Arg/Arg and XRCC1-280 Arg/ Arg + Arg/His; There was no significant difference for CYP1A1-Msp1, GSTT1, mEH-exon4, XRCC1-399 genotype between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  The genetic polymorphisms of CYP1A1-exon7, GSTM1, mEH-exon3, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.
authors.affiliation: School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhou
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2; D004268:DNA-Binding Proteins; D005982:Glutathione Transferase; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; C413545:glutathione S-transferase T1