title: Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women.
abstract: BACKGROUND
  The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women.
  
  
  METHODS
  A total of 157 postmenopausal women were included in the study: 70 had low (≤0.76 μM), 42 intermediate (0.76-1.42 μM) and 45 high (≥1.42 μM) urinary phytate concentrations. Densitometry values for neck were measured at enrollment and after 12 months (lumbar spine and femoral neck), and 10-year risk fracture was calculated using the tool FRAX(®).
  
  
  RESULTS
  Individuals with low InsP6 levels had significantly greater bone mass loss in the lumbar spine (3.08 ± 0.65 % vs. 0.43 ± 0.55 %) than did those with high phytate levels. Moreover, a significantly greater percentage of women with low than with high InsP6 levels showed more than 2 % of bone mass loss in the lumbar spine (55.6 vs. 20.7 %). The 10-year fracture probability was also significantly higher in the low-phytate group compared to the high-phytate group, both in hip (0.37 ± 0.06 % vs 0.18 ± 0.04 %) and major osteoporotic fracture (2.45 ± 0.24 % vs 1.83 ± 0.11 %).
  
  
  CONCLUSIONS
  It can be concluded that high urinary phytate concentrations are correlated with reduced bone mass loss in lumbar spine over 12 months and with reduced 10-year probability of hip and major osteoporotic fracture, indicating that increased phytate consumption can prevent development of osteoporosis.
authors.affiliation: Servicio de Prevención de Riesgos Laborales de GESMA (Gestión Sanitaria de Mallorca), Palma de Mallorca, Spain.
authors.forename: Angel A
authors.initials: AA
authors.lastname: López-González
authors.forename: Félix
authors.initials: F
authors.lastname: Grases
authors.forename: Nieves
authors.initials: N
authors.lastname: Monroy
authors.forename: Bartolome
authors.initials: B
authors.lastname: Marí
authors.forename: Ma Teófila
authors.initials: MT
authors.lastname: Vicente-Herrero
authors.forename: Fernando
authors.initials: F
authors.lastname: Tur
authors.forename: Joan
authors.initials: J
authors.lastname: Perelló
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging*; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging; D010833:Phytic Acid / Q000652:urine*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D010833:Phytic Acid