title: Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth.
abstract: STAT1 is activated by IFNs and other cell signals. Following activation, STAT1 is translocated to the nuclei and activates transcription of IFN-stimulated genes. Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the STAT1 pathway confers cellular resistance to DNA-damaging agents and mediates aggressive tumor growth. Recent advances in the development of Janus-activated kinase/Stat inhibitors and peptide inhibitors specific for individual Stat proteins may provide new insights into the controversial functions of this pathway.
authors.affiliation: Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Nikolai N
authors.initials: NN
authors.lastname: Khodarev
authors.forename: Bernard
authors.initials: B
authors.lastname: Roizman
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Weichselbaum
mesh_terms: D004249:DNA Damage; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D011836:Radiation Tolerance; D050794:STAT1 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D007372:Interferons