title: The coronavirus E protein: assembly and beyond.
abstract: The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.
authors.affiliation: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. truch2@jhmi.edu
authors.forename: Travis R
authors.initials: TR
authors.lastname: Ruch
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Machamer
mesh_terms: D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000378:metabolism; D017934:Coronavirus / Q000502:physiology*; D007473:Ion Channels / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000378:metabolism*; D019065:Virus Assembly; D057074:Virus Release
chemical_list: D007473:Ion Channels; D014759:Viral Envelope Proteins