title: Recent advances in iridium-catalyzed asymmetric hydrogenation: new catalysts, substrates and applications in total synthesis.
abstract: Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field. We have developed a new type of P,O-ligand that was successfully applied to the asymmetric  hydrogenation of α,β-unsaturated carbonyl compounds. Furthermore we have demonstrated the potential of known iridium catalysts in the hydrogenation of α,β-unsaturated boronic esters. And finally we could demonstrate the utility of iridium-catalyzed asymmetric hydrogenation  in the formal synthesis of the natural product Platensimycin.
authors.affiliation: Department of Chemistry, University of Basel, Basel, Switzerland. adnan.ganic@unibas.ch
authors.forename: Adnan
authors.initials: A
authors.lastname: Ganić
authors.forename: Denise
authors.initials: D
authors.lastname: Rageot
authors.forename: Lars
authors.initials: L
authors.lastname: Tröndlin
authors.forename: Andreas
authors.initials: A
authors.lastname: Pfaltz