title: Administration of growth factors for bone regeneration.
abstract: Growth factors (GFs) such as BMPs, FGFs, VEGFs and IGFs have significant impacts on osteoblast behavior, and thus have been widely utilized for bone tissue regeneration. Recently, securing biological stability for a sustainable and controllable release to the target tissue has been a challenge to practical applications. This challenge has been addressed to some degree with the development of appropriate carrier materials and delivery systems. This review highlights the importance and roles of those GFs, as well as their proper administration for targeting bone regeneration. Additionally, the in vitro and in vivo performance of those GFs with or without the use of carrier systems in the repair and regeneration of bone tissue is systematically addressed. Moreover, some recent advances in the utility of the GFs, such as using fusion technology, are also reviewed.
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 330-714, Korea.
authors.forename: Ye-Rang
authors.initials: YR
authors.lastname: Yun
authors.forename: Jun Hyeog
authors.initials: JH
authors.lastname: Jang
authors.forename: Eunyi
authors.initials: E
authors.lastname: Jeon
authors.forename: Wonmo
authors.initials: W
authors.lastname: Kang
authors.forename: Sujin
authors.initials: S
authors.lastname: Lee
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Won
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Ivan
authors.initials: I
authors.lastname: Wall
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004335:Drug and Narcotic Control; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000494:pharmacology*; D057170:Translational Research, Biomedical / Q000331:legislation & jurisprudence
chemical_list: D004337:Drug Carriers; D036341:Intercellular Signaling Peptides and Proteins