title: [The impact of gen polymorphism of subunits of receptors of thrombocytes GP IIb/IIIa on variation of indicators of thrombocyte hemostasis in obstetrics practice].
abstract: The article presents the results of study of the impact of gen polymorphism of subunits of receptors of thrombocytes GP Ilb/IIIa on variation of quantitative, functional and morphometric parameters of thrombocytes in 408 puerperae. The heterozygous variant of mutation was established in women with physiologically progress of pregnancy and delivery and in women with clinical manifestations of thrombophilia. The homozygous variant was established only in women with thrombophilia. The relationship is established between the presence of hetero- and homozygous mutations of gen of subunits of receptors of thrombocytes GP IIb/IIIa and inclination to hypercoagulation. This relationship manifests itself in increasing of degree of thrombocytes aggregation with all inductors and as well as in increasing of functional activity and appearance of young active cells, according morphometric analysis data. The application of computer morphometry of thrombocytes in the study made it possible to ascertain the activization of thrombocyte component of hemostasis in healthy women and availability of heterozygous mutation of gen of subunits of receptors of thrombocytes GP IIb/IIIa (PlA1/PlA2).
authors.forename: T P
authors.initials: TP
authors.lastname: Bondar'
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Muratova
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D019851:Thrombophilia / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex