title: Serum pharmacokinetics in patients treated with transarterial chemoembolization (TACE) using two types of epirubicin-loaded microspheres.
abstract: OBJECTIVE
  The purpose of this study was the pharmacokinetic (PK) profile assessment in the serum of patients affected by hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) with drug-eluting beads.
  
  
  METHODS
  This study included 20 patients, 12 treated with DC Bead® and 8 with HepaSphere Microsphere®, preloaded with epirubicin. No patient randomization was used for the inclusion in one group or in the other. Peripheral blood samples were obtained from all patients after the treatment, until 24 hours past the procedure.
  
  
  RESULTS
  The pharmacokinetic study showed low peak serum epirubicin concentrations with greater drug exposure for the DC Bead® group (p<0.05). The highest drug concentration after microsphere injection was observed at 5 minutes in all 20 patients. In the time interval between 1 and 24 hours after TACE, persisting levels of epirubicin were detected in peripheral blood samples.
  
  
  CONCLUSIONS
  A persistent and sustained drug elution for both types of microparticles was found.
authors.affiliation: Laboratory for Environmental and Toxicological Testing, IRCCS Fondazione S. Maugeri, Istituto Scientifico di Pavia, Pavia, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sottani
authors.forename: Guido
authors.initials: G
authors.lastname: Poggi
authors.forename: Pietro
authors.initials: P
authors.lastname: Quaretti
authors.forename: Mario
authors.initials: M
authors.lastname: Regazzi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Montagna
authors.forename: Erica
authors.initials: E
authors.lastname: Quaquarini
authors.forename: Marcello
authors.initials: M
authors.lastname: Imbriani
authors.forename: Emanuela
authors.initials: E
authors.lastname: Leoni
authors.forename: Pamela
authors.initials: P
authors.lastname: Di Cesare
authors.forename: Alberto
authors.initials: A
authors.lastname: Riccardi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bernardo
authors.forename: Claudio
authors.initials: C
authors.lastname: Minoia
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality; D016461:Chemoembolization, Therapeutic; D002851:Chromatography, High Pressure Liquid; D015251:Epirubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008863:Microspheres; D011786:Quality Control
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin