title: Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: associations and prognostic implications.
abstract: OBJECTIVE
  To investigate the relationship of coronary artery calcium (CAC) scores with common carotid artery intima media thickness (CCA-IMT), albuminuria and inflammatory factors in type 2 diabetes.
  
  
  RESULTS
  128 asymptomatic type 2 diabetic patients, with at least one cardiovascular risk factor in addition to diabetes, were included in the study. CAC scores, carotid arteries plaque formation and CCA-IMT were assessed. The patients were followed for a mean period of 36.6 ± 3.3 months. Linear regression analysis identified the logarithmically transformed (Ln) albuminuria (β=0.32, P=0.007), age (β=0.04, P=0.001) and the uric acid (β=0.13, P=0.04) as independent determinants of the CAC score. During follow-up period, cardiovascular events occurred in 18 out of 46 patients with CAC score ≥100 compared with 5 out of 82 patients with CAC score <100 (log rank, P<0.0001). Multivariate Cox proportional hazards analysis identified LnCAC score (P<0.0001), LnAlbuminuria (P=0.01) and uric acid (P=0.03) as independent predictors for cardiovascular events.
  
  
  CONCLUSIONS
  There was a significant relationship between CAC score, albuminuria and inflammation in patients with type 2 diabetes. LnCAC score together with LnAlbuminuria and uric acid were identified as independent predictors of cardiovascular events in these patients.
authors.affiliation: Haydarpaşa Numune Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Akın
authors.initials: A
authors.lastname: Dayan
authors.forename: Burcu
authors.initials: B
authors.lastname: Narin
authors.forename: Murat
authors.initials: M
authors.lastname: Biteker
authors.forename: Sukru
authors.initials: S
authors.lastname: Aksoy
authors.forename: Hakan
authors.initials: H
authors.lastname: Fotbolcu
authors.forename: Dursun
authors.initials: D
authors.lastname: Duman
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000150:complications* / Q000378:metabolism; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D015992:Body Mass Index; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D061205:Vascular Calcification / Q000378:metabolism*
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human