title: IRView: a database and viewer for protein interacting regions.
abstract: Protein-protein interactions (PPIs) are mediated through specific regions on proteins. Some proteins have two or more protein interacting regions (IRs) and some IRs are competitively used for interactions with different proteins. IRView currently contains data for 3417 IRs in human and mouse proteins. The data were obtained from different sources and combined with annotated region data from InterPro. Information on non-synonymous single nucleotide polymorphism sites and variable regions owing to alternative mRNA splicing is also included. The IRView web interface displays all IR data, including user-uploaded data, on reference sequences so that the positional relationship between IRs can be easily understood. IRView should be useful for analyzing underlying relationships between the proteins behind the PPI networks.
  
  
  BACKGROUND
  IRView is publicly available on the web at http://ir.hgc.jp/
authors.affiliation: Division of Interactome Medical Sciences, Institute of Medical Science, The University of Tokyo, Tokyo 108-8039, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fujimori
authors.forename: Naoya
authors.initials: N
authors.lastname: Hirai
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Masuoka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Oshikubo
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Takanori
authors.initials: T
authors.lastname: Washio
authors.forename: Ayumu
authors.initials: A
authors.lastname: Saito
authors.forename: Masao
authors.initials: M
authors.lastname: Nagasaki
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyano
authors.forename: Etsuko
authors.initials: E
authors.lastname: Miyamoto-Sato
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D051379:Mice; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000032:analysis*; D012984:Software
chemical_list: D011506:Proteins