title: Cholagogue-induced gallbladder emptying in the diagnosis of canine biliary obstruction.
abstract: The efficacy of ultrasound-guided cholagogue-induced gallbladder emptying for differentiating obstructive from non-obstructive hepatobiliary diseases was studied in icteric dogs. In 7 healthy Beagle dogs, Lipofundin 20% infusion (2 ml/kg orally) evoked a vigorous gallbladder contraction of 44.2% (range: 35.3-57.6%) and proved to be a useful, well-tolerable meal for routine use. In 24 icteric dogs, gallbladder contraction was evoked by different cholagogues: the maximum reduction in gallbladder volume (%) for the three non-obstructive icteric dogs was 43.9% (range, 39.0-46.5%). The average gallbladder contraction of the 21 dogs with biliary obstruction was less than 5%. In conclusion, the stimulation of gallbladder contraction with orally applied magnesium sulphate (MgSO4) or Lipofundin can be well demonstrated by ultrasound in dogs. The examination of cholagogue-induced gallbladder emptying is a valuable technique in icteric patients to indicate surgical intervention.
authors.affiliation: Szent István University Department and Clinic of Internal Medicine István u. 2 H-1078 Budapest Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Sterczer
authors.forename: Jenő
authors.initials: J
authors.lastname: Reiczigel
authors.forename: Roland
authors.initials: R
authors.lastname: Psáder
authors.forename: Kinga
authors.initials: K
authors.lastname: Pápa
authors.forename: Károly
authors.initials: K
authors.lastname: Vörös
authors.forename: Akos
authors.initials: A
authors.lastname: Pap
mesh_terms: D000818:Animals; D002756:Cholagogues and Choleretics; D002779:Cholestasis; D004285:Dogs; D005704:Gallbladder; D016473:Gallbladder Emptying
chemical_list: D002756:Cholagogues and Choleretics