title: Maternal BMI, glucose tolerance, and adverse pregnancy outcomes.
abstract: OBJECTIVE
  The purpose of this study was to estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.
  
  
  METHODS
  In this secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, which was defined as a 50-g glucose loading test between 135 and 199 mg/dL and fasting glucose level of <95 mg/dL, we modeled the association between pregravid BMI, OGTT results, and both pregnancy complications and neonatal adiposity.
  
  
  RESULTS
  Among 1250 participants, both pregravid BMI and glucose at hour 3 of the OGTT were associated with increased risk of gestational hypertension. Maternal pregravid BMI also was associated positively with large-for-gestational-age infants; both maternal BMI and fasting glucose were associated with birthweight z-score and neonatal fat mass.
  
  
  CONCLUSIONS
  Among women with untreated mild gestational glucose intolerance, pregravid BMI is associated with increased gestational hypertension, birthweight, and neonatal fat mass, independent of OGTT values.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology at University of North Carolina School of Medicine, Chapel Hill, NC 27599-7516, USA. astuebe@med.unc.edu
authors.forename: Alison M
authors.initials: AM
authors.lastname: Stuebe
authors.forename: Mark B
authors.initials: MB
authors.lastname: Landon
authors.forename: Yinglei
authors.initials: Y
authors.lastname: Lai
authors.forename: Catherine Y
authors.initials: CY
authors.lastname: Spong
authors.forename: Marshall W
authors.initials: MW
authors.lastname: Carpenter
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ramin
authors.forename: Brian
authors.initials: B
authors.lastname: Casey
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wapner
authors.forename: Michael W
authors.initials: MW
authors.lastname: Varner
authors.forename: Dwight J
authors.initials: DJ
authors.lastname: Rouse
authors.forename: Anthony
authors.initials: A
authors.lastname: Sciscione
authors.forename: Patrick
authors.initials: P
authors.lastname: Catalano
authors.forename: Margaret
authors.initials: M
authors.lastname: Harper
authors.forename: George
authors.initials: G
authors.lastname: Saade
authors.forename: Yoram
authors.initials: Y
authors.lastname: Sorokin
authors.forename: Alan M
authors.initials: AM
authors.lastname: Peaceman
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Tolosa
mesh_terms: D050154:Adiposity; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology*; D018149:Glucose Intolerance / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D007231:Infant, Newborn; D016014:Linear Models; D016015:Logistic Models; D009765:Obesity / Q000150:complications*; D011247:Pregnancy