title: Synaptic plasticity regulated by protein-protein interactions and posttranslational modifications.
abstract: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. AMPARs dynamically cycle in and out of the postsynaptic membrane in an activity-dependent manner. Because the number and functional properties of AMPARs at the postsynapse determine the efficacy of synaptic transmission, molecular mechanisms underlying AMPAR trafficking and gating are considered to have a central role in synaptic plasticity, a basic mechanism for learning and memory. In this chapter, we review the current knowledge about the regulatory mechanisms for AMPAR trafficking and channel gating by protein-protein interactions and posttranslational modifications. Especially, we focus on the recently established mode of action of the AMPAR auxiliary subunit, stargazin/TARPs, and PSD-95 scaffold. Furthermore, we introduce novel players in AMPAR regulation, PSD-95 palmitoylating enzymes and epilepsy-related ligand, LGI1.
authors.affiliation: Division of Membrane Physiology, Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Yokoi
authors.forename: Masaki
authors.initials: M
authors.lastname: Fukata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fukata
mesh_terms: D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D009473:Neuronal Plasticity / Q000502:physiology*; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D018091:Receptors, AMPA / Q000737:chemistry / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*
chemical_list: D018091:Receptors, AMPA