title: Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides.
abstract: The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).
authors.affiliation: Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Ambrus
authors.forename: Jill I
authors.initials: JI
authors.lastname: Halliday
authors.forename: Nicholas
authors.initials: N
authors.lastname: Kanizaj
authors.forename: Nathan
authors.initials: N
authors.lastname: Absalom
authors.forename: Kasper
authors.initials: K
authors.lastname: Harpsøe
authors.forename: Thomas
authors.initials: T
authors.lastname: Balle
authors.forename: Mary
authors.initials: M
authors.lastname: Chebib
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: McLeod
mesh_terms: D000818:Animals; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008954:Models, Biological; D015394:Molecular Structure; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011978:Receptors, Nicotinic / Q000737:chemistry / Q000187:drug effects; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: C579165:Chrna7 protein, rat; D008301:Maleimides; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor