title: ¹H, ¹³C and ¹⁵N resonance assignments of the pyrin domain from human PYNOD.
abstract: PYNOD is a novel protein belonging to a large family of proteins containing the nucleotide-binding and oligomerization domain (NOD) involved in inflammation and apoptosis. Human PYNOD inhibits inflammatory response mediated by caspase-1 and apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC). Here we report the (1)H, (13)C and (15)N resonance assignments and secondary structure identification of the pyrin domain (PYD) of human PYNOD as the first step towards elucidating the structural basis of the anti-inflammatory activity of PYNOD.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Ming-Yuan
authors.initials: MY
authors.lastname: Su
authors.forename: Chung-I
authors.initials: CI
authors.lastname: Chang
authors.forename: Chi-Fon
authors.initials: CF
authors.lastname: Chang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D002247:Carbon Isotopes; D002352:Carrier Proteins / Q000737:chemistry*; D006801:Humans; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary; D011522:Protons
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D002247:Carbon Isotopes; D002352:Carrier Proteins; C494352:NLRP10 protein, human; D009587:Nitrogen Isotopes; D011522:Protons