title: Steroid-responsive focal epilepsy with focal dystonia accompanied by glutamate receptor delta2 antibody.
abstract: This report describes a rare case presenting with focal epilepsy and focal dystonia associated with glutamate receptor δ2 antibody. The patient was a 47-year-old male patient with neurosyphilis. He presented with an intractable focal seizure spreading from the right arm, with dystonia of the left leg. The IgG antibody of glutamate receptor δ2 was detected. Ictal and interictal SPECT suggested focal epilepsy in the left frontal cortex. Antibiotic and antiepileptic drugs were ineffective, although steroid pulse therapy effectively diminished the patient's symptoms. Inflammatory mechanisms may have contributed to this disorder.
authors.affiliation: Department of Neurology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, Japan. hideyukimatsumoto.jp@gmail.com
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Okabe
authors.forename: Minako
authors.initials: M
authors.lastname: Hirakawa-Yamada
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Noboru
authors.initials: N
authors.lastname: Satoh
authors.forename: Yukifusa
authors.initials: Y
authors.lastname: Igeta
authors.forename: Hideji
authors.initials: H
authors.lastname: Hashida
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D020821:Dystonic Disorders / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000150:complications* / Q000000981:diagnostic imaging; D017470:Receptors, Glutamate / Q000276:immunology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D001324:Autoantigens; D017470:Receptors, Glutamate; C107913:glutamate receptor delta 2