title: A robust, high-sensitivity stealth probe for peptidases.
abstract: A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off-ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.
authors.affiliation: Laboratoire de Chimie, CNRS, École Normale Supérieure de Lyon, 46 Allée d'Italie, F-69364 Lyon, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Thorn-Seshold
authors.forename: Monica
authors.initials: M
authors.lastname: Vargas-Sanchez
authors.forename: Sean
authors.initials: S
authors.lastname: McKeon
authors.forename: Jens
authors.initials: J
authors.lastname: Hasserodt
mesh_terms: D019793:Fluorescein / Q000138:chemical synthesis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010447:Peptide Hydrolases / Q000032:analysis* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D010447:Peptide Hydrolases; D019793:Fluorescein