title: [Effects of magnesium intake on expression of insulin receptor in type 2 diabetes rats].
abstract: OBJECTIVE
  To investigate the effects of magnesium intake on expression of insulin receptor in type 2 diabetes rats.
  
  
  METHODS
  The models of type 2 diabetes rats were established by feeding with high-fat-diet and injecting streptozotocin (STZ). Rats were randomly assigned to four groups. The high-fat-diets were administrated magnesium at a dose of 2000 (high magnesium group), 1000 (medium magnesium group) and 200 (low magnesium group). Model control group was only fed with high-fat-diet. Normal control group was fed with common diet. Rats ate freely for four weeks. Fasting blood glucose was detected by glucose oxidase method.. Insulin was detected by radio-immunity method. The expression levels of IR of pancreas and skeletal muscle were detected by immunohistochemistry method.
  
  
  RESULTS
  The immunohistochemistry pictures were analyzed by Image-Pro Plus. Compared with model control group, the expression levels of IR of pancreas and skeletal muscle were 0.341 +/- 0.001 and 0.346 +/- 0.002, increased and fasting blood glucose decreased significantly in high magnesium group (P < 0.05 ).
  
  
  CONCLUSIONS
  Magnesium intake may increase the expression levels of IR of pancreas and skeletal muscle, and decrease fasting blood glucose in type 2 diabetes rats.
authors.affiliation: Medical Collage of Qingdao University, Qingdao 266021, China.
authors.forename: Pengdi
authors.initials: P
authors.lastname: Cong
authors.forename: Jinyi
authors.initials: J
authors.lastname: Zhong
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Sun
authors.forename: Lei
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D011972:Receptor, Insulin; D008274:Magnesium