title: The effect of abdominal radical trachelectomy on ovarian reserve: serial changes in serum anti-müllerian hormone levels.
abstract: OBJECTIVE
  To evaluate the effect of abdominal radical trachelectomy on ovarian reserve and compare it with abdominal radical hysterectomy and a control group that did not have surgery.
  
  
  METHODS
  We enrolled eighteen women who had abdominal radical trachelectomy with pelvic lymphadenectomy and sixteen patients who had abdominal radical hysterectomy for this study. Ten thousand one hundred eighty-six women were also included as a control group for comparison. The Mann-Whitney U test was used for comparison of patient characteristics and comparison of serum anti-Müllerian hormone levels between the three groups.
  
  
  RESULTS
  Serum anti-Müllerian hormone levels in patients with abdominal radical trachelectomy were significantly higher than those of patients with abdominal radical hysterectomy (P<0.05). Serum anti-Müllerian hormone levels in the abdominal radical hysterectomy group were significantly lower than those in the control group (P=0.02), with no significant difference between the abdominal radical trachelectomy and control groups. These data indicated that abdominal radical trachelectomy did not affect ovarian function with respect to ovarian reserve and the response to ovarian stimulation.
  
  
  CONCLUSIONS
  Serum anti-Müllerian hormone levels could be useful as a marker of ovarian reserve after abdominal radical trachelectomy. It is important to avoid postoperative complications causing a reduction in ovarian function to accomplish fertility-sparing surgery.
authors.affiliation: 1. Department of Gynecologic Oncology, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi 6738558, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Muraji
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sudo
authors.forename: Shinichi
authors.initials: S
authors.lastname: Iwasaki
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ueno
authors.forename: Senn
authors.initials: S
authors.lastname: Wakahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Nishimura