title: Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images.
abstract: OBJECTIVE
  Our aim was to evaluate the hepatocyte transporters in focal nodular hyperplasia (FNH) and FNH-like lesions and to correlate the grade of its expression with signal intensity on the hepatobiliary phase (HB phase) of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI).
  
  
  METHODS
  Thirteen histopathological confirmed cases including eight with EOB-MRI were studied. Immunohistochemical staining for transporter was performed and its grade semiquantitatively analyzed.
  
  
  RESULTS
  Histopathologically, ten cases showed almost equal organic anion transporter polypeptide (OATP) 8 expression relative to the surrounding liver; the remaining three showed stronger OATP8 expression. In eight cases with EOB-MRI, two demonstrated more hyperintensity on the HB phase, and their OATP8 expression was stronger compared with the surrounding liver. The remaining six cases showed isointensity on the HB phase and revealed almost equal OATP8 expression. The expression of export transporter multi-drug-resistant proteins (MRP) 1 and 2 were almost equal relative to the surrounding liver in most cases (11/12, 92 %; 11/12, 92 %, respectively), whereas MRP3 focally overexpressed in 75 % (9/12) of cases.
  
  
  CONCLUSIONS
  FNH and FNH-like nodules revealed equal or stronger OATP8 expression than background liver. OATP8 expression showed significant correlation with signal intensity on the HB phase.
authors.affiliation: Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa 920-8640, Japan. noritin@f7.dion.ne.jp
authors.forename: Norihide
authors.initials: N
authors.lastname: Yoneda
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsui
authors.forename: Azusa
authors.initials: A
authors.lastname: Kitao
authors.forename: Ryuuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Kazuto
authors.initials: K
authors.lastname: Kozaka
authors.forename: Wataru
authors.initials: W
authors.lastname: Koda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Gabata
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sato
authors.forename: Yasuni
authors.initials: Y
authors.lastname: Nakanuma
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis*; D019786:Gadolinium DTPA; D022781:Hepatocytes / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D026901:Membrane Transport Proteins; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA