title: A rigorous approach for testing the constructionist hypotheses of brain function.
abstract: Although the target article provides strong evidence against the locationist view, evidence for the constructionist view is inconclusive, because co-activation of brain regions does not necessarily imply connectivity between them. We propose a rigorous approach wherein connectivity between co-activated regions is first modeled using exploratory Granger causality, and then confirmed using dynamic causal modeling or Bayesian modeling.
authors.affiliation: Auburn University MRI Research Center, Department of Electrical and Computer Engineering, and Department of Psychology, Auburn University, Auburn, AL 36849, USA. gopi@auburn.edu
authors.forename: Gopikrishna
authors.initials: G
authors.lastname: Deshpande
authors.forename: K
authors.initials: K
authors.lastname: Sathian
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Buckhalt
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D059906:Neuroimaging; D011859:Radiography