title: Bioresorbable polymer coated drug eluting stent: a model study.
abstract: In drug eluting stent technologies, an increased demand for better control, higher reliability, and enhanced performances of drug delivery systems emerged in the last years and thus offered the opportunity to introduce model-based approaches aimed to overcome the remarkable limits of trial-and-error methods. In this context a mathematical model was studied, based on detailed conservation equations and taking into account the main physical-chemical mechanisms involved in polymeric coating degradation, drug release, and restenosis inhibition. It allowed highlighting the interdependence between factors affecting each of these phenomena and, in particular, the influence of stent design parameters on drug antirestenotic efficacy. Therefore, the here-proposed model is aimed to simulate the diffusional release, for both in vitro and the in vivo conditions: results were verified against various literature data, confirming the reliability of the parameter estimation procedure. The hierarchical structure of this model also allows easily modifying the set of equations describing restenosis evolution to enhance model reliability and taking advantage of the deep understanding of physiological mechanisms governing the different stages of smooth muscle cell growth and proliferation. In addition, thanks to its simplicity and to the very low system requirements and central processing unit (CPU) time, our model allows obtaining immediate views of system behavior.
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano , Via Mancinelli 7, 20131 Milano, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Rossi
authors.forename: Tommaso
authors.initials: T
authors.lastname: Casalini
authors.forename: Edoardo
authors.initials: E
authors.lastname: Raffa
authors.forename: Maurizio
authors.initials: M
authors.lastname: Masi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Perale
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D054855:Drug-Eluting Stents; D008962:Models, Theoretical; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D020099:Coated Materials, Biocompatible; D004364:Pharmaceutical Preparations; D011108:Polymers