title: The kinomes of apicomplexan parasites.
abstract: Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
authors.affiliation: Bioinformatics and Genomics Laboratory, World Premier International (WPI) Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamadaoka, Suita, 565-0871 Osaka, Japan. diego@ifrec.osaka-u.ac.jp
authors.forename: Diego
authors.initials: D
authors.lastname: Miranda-Saavedra
authors.forename: Toni
authors.initials: T
authors.lastname: Gabaldón
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Barton
authors.forename: Gordon
authors.initials: G
authors.lastname: Langsley
authors.forename: Christian
authors.initials: C
authors.lastname: Doerig
mesh_terms: D016782:Apicomplexa / Q000201:enzymology* / Q000235:genetics / Q000502:physiology*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D011494:Protein Kinases