title: Sesquiterpenoids from Incarvillea arguta: absolute configuration and biological evaluation.
abstract: Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguta. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca(2+) influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 μM (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Wu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Dong
authors.forename: Lan
authors.initials: L
authors.lastname: Shen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D029402:Bignoniaceae / Q000737:chemistry*; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C574824:diincarvilone A; C574825:diincarvilone B; D009569:Nitric Oxide; D002118:Calcium