title: Manganese(III)-mediated radical cyclisations for the (Z)-selective synthesis of exo-alkylidene pyrrolidinones and pyrrolidines.
abstract: The cyclisation of alkynyl amido- and amino-malonates in the presence of manganese(III) acetate gives exo-alkylidene pyrrolidinones and pyrrolidines with a preference for the (Z)-alkene product isomer.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Harriet A
authors.initials: HA
authors.lastname: Keane
authors.forename: Wilfried
authors.initials: W
authors.lastname: Hess
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Burton
mesh_terms: D003500:Cyclization; D007536:Isomerism; D008314:Malonates / Q000138:chemical synthesis / Q000737:chemistry; D008345:Manganese / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008314:Malonates; D011759:Pyrrolidines; D011760:Pyrrolidinones; D008345:Manganese