title: [Helicobacter pylori infection in pancreatic cancer].
abstract: Despite some advances in the oncological managament, pancreatic cancer remains a clinical problem and has remained leading cause of cancer deaths. The association between Helicobacter pylori (H. pylori) infection and pancreatic was suggested, but the issue remains of contentious. The aim of the study was to determine the relationship between H. pylori infection and pancreatic cancer development on a sample of Polish population.
  
  
  METHODS
  139 patients with pancreatic cancer and 177 controls were included in the study. Seropositivity for H. pylori, including CagA protein were assessed by the enzyme-linked immunosorbent assay and Western blot, respectively. The frequency of H. pylori in pancreatic cancer patients and controls were compared adjusted for age, sex, cigarette smoking and a family history of cancer in the logistic regresion model.
  
  
  RESULTS
  No significant differences between pancreatic cancer patients and controls were seen according to H. pylori seropositivity (87.1 vs 82.5%; OR = 1.27; CI95%: 0.64-2.61; p = 0.514) and CagA seropositivity (83.5 vs 84.9%; OR = 0.90; CI95%: 0.46-1.73; p = 0.744).
  
  
  CONCLUSIONS
  The study didn't support previous observations of H. pylori infection as a plausible pathogenic risk factor for pancreatic cancer development. The high prevalence of infection in the control group may explain why the earlier reports of a positive association between H. pylori infection and pancreatic cancer could not be confirmed in the study.
authors.affiliation: Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland. k.gastro@sci.pam.szczecin.pl
authors.forename: Alicja
authors.initials: A
authors.lastname: Gawin
authors.forename: Thomas
authors.initials: T
authors.lastname: Wex
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Ławniczak
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: Teresa
authors.initials: T
authors.lastname: Starzyńska
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000382:microbiology*; D011044:Poland / Q000453:epidemiology; D012698:Serologic Tests