title: Treatment of refractory intracranial hypertension with 23.4% saline in children with severe traumatic brain injury.
abstract: The safety and efficacy of osmotic therapy with mannitol and 3% saline in the pediatric head-injured population has been widely reported; the use of 23.4% saline in children for the treatment of refractory intracranial hypertension has not. The clinical and physiologic responses of multiple 23.4% saline boluses in two children with severe traumatic brain injury (TBI) are presented. No complications were associated with the use of 23.4% saline in either patient.
authors.affiliation: Neuroscience Institute, The Queen's Medical Center, Honolulu, HI 96813, USA. kazuma.nakagawa@hawaii.edu
authors.forename: Kazuma
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Cherylee W J
authors.initials: CW
authors.lastname: Chang
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Koenig
authors.forename: Mihae
authors.initials: M
authors.lastname: Yu
authors.forename: Sheri
authors.initials: S
authors.lastname: Tokumaru
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D001930:Brain Injuries / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007223:Infant; D019586:Intracranial Hypertension / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D012462:Saline Solution, Hypertonic