title: Synthesis and evaluation of atropos dihydro-5H-dibenzazepinium halide PTCs derived from α-methylbenzylamine.
abstract: A short synthetic route to diastereoisomeric atropos dihydro-5H-dibenz[c,e]azepinium salts via reaction of a single enantiomer of (R)-α-methylbenzylamine with a racemic atropos biphenol derivative is described. Compounds prepared via this approach are used to provide strong evidence that structurally related tropos dihydro-5H-dibenz[c,e]azepinium salts preferentially react via a single conformation in PTC reactions involving glycine imine enolates.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK. b.lygo@nottingham.ac.uk
authors.forename: Barry
authors.initials: B
authors.lastname: Lygo
authors.forename: Umar
authors.initials: U
authors.lastname: Butt
authors.forename: Maria
authors.initials: M
authors.lastname: Cormack
mesh_terms: D001381:Azepines / Q000138:chemical synthesis*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D006865:Hydrogenation; D008958:Models, Molecular; D015394:Molecular Structure; D010627:Phenethylamines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001381:Azepines; D006219:Halogens; D010627:Phenethylamines; C033198:1-phenethylamine