title: Boceprevir dosing for late responders and null responders: the role of bridging data between treatment-naïve and -experienced subjects.
authors.affiliation: Division of Pharmacometrics, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA. Jeffry.Florian@fda.hhs.gov
authors.forename: Jeffry
authors.initials: J
authors.lastname: Florian
authors.forename: Pravin R
authors.initials: PR
authors.lastname: Jadhav
authors.forename: Shashi
authors.initials: S
authors.lastname: Amur
authors.forename: Ruben
authors.initials: R
authors.lastname: Ayala
authors.forename: Patrick
authors.initials: P
authors.lastname: Harrington
authors.forename: Poonam
authors.initials: P
authors.lastname: Mishra
authors.forename: Jules
authors.initials: J
authors.lastname: O'Rear
authors.forename: Michael
authors.initials: M
authors.lastname: Pacanowski
authors.forename: Sarah
authors.initials: S
authors.lastname: Robertson
authors.forename: Mary
authors.initials: M
authors.lastname: Singer
authors.forename: Greg
authors.initials: G
authors.lastname: Soon
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Murray
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017326:Clinical Trials, Phase III as Topic / Q000379:methods; D017277:Drug Approval / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods*; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination / Q000592:standards; D019317:Evidence-Based Medicine / Q000379:methods; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012254:Ribavirin / Q000627:therapeutic use; D014481:United States
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide; D011392:Proline