title: The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate.
abstract: The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg(-1) body mass of sodium bicarbonate (NaHCO(3)) (BICARB), or a placebo of 0.045 g kg(-1) body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO(3) is unlikely to be due to a decreased oxidative stress.
authors.affiliation: Department of Sport, Health and Exercise Science, University of Hull, Hull HU6 7RX, UK.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Peart
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kirk
authors.forename: Angela R
authors.initials: AR
authors.lastname: Hillman
authors.forename: Leigh A
authors.initials: LA
authors.lastname: Madden
authors.forename: Jason C
authors.initials: JC
authors.lastname: Siegler
authors.forename: Rebecca V
authors.initials: RV
authors.lastname: Vince
mesh_terms: D000284:Administration, Oral; D000471:Alkalosis; D015308:Anaerobic Threshold / Q000187:drug effects / Q000502:physiology*; D050884:HSP72 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D058573:Performance-Enhancing Substances / Q000008:administration & dosage*; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D012420:Running / Q000502:physiology*; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D050884:HSP72 Heat-Shock Proteins; D058573:Performance-Enhancing Substances; D017693:Sodium Bicarbonate