title: Regulation of glucose transport by insulin: traffic control of GLUT4.
abstract: Despite daily fasting and feeding, plasma glucose levels are normally maintained within a narrow range owing to the hormones insulin and glucagon. Insulin increases glucose uptake into fat and muscle cells through the regulated trafficking of vesicles that contain glucose transporter type 4 (GLUT4). New insights into insulin signalling reveal that phosphorylation events initiated by the insulin receptor regulate key GLUT4 trafficking proteins, including small GTPases, tethering complexes and the vesicle fusion machinery. These proteins, in turn, control GLUT4 movement through the endosomal system, formation and retention of specialized GLUT4 storage vesicles and targeted exocytosis of these vesicles. Understanding these processes may help to explain the development of insulin resistance in type 2 diabetes and provide new potential therapeutic targets.
authors.affiliation: Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48105, USA. letod@umich.edu
authors.forename: Dara
authors.initials: D
authors.lastname: Leto
authors.forename: Alan R
authors.initials: AR
authors.lastname: Saltiel
mesh_terms: D000818:Animals; D001692:Biological Transport; D004705:Endocytosis; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051275:Glucose Transporter Type 4; D007328:Insulin; D005947:Glucose