title: Pharmacogenomics and public health: implementing 'populationalized' medicine.
abstract: Pharmacogenomics are frequently considered in personalized medicine to maximize therapeutic benefits and minimize adverse drug reactions. However, there is a movement towards applying this technology to populations, which may produce the same benefits, while saving already scarce health resources. We conducted a narrative literature review to examine how pharmacogenomics and public health can constructively intersect, particularly in resource-poor settings. We identified 27 articles addressing the research question. Real and theoretical connections between public health and pharmacogenomics were presented in the areas of disease, drugs and public policy. Suggested points for consideration, such as educational efforts and cultural acceptability, were also provided. Including pharmacogenomics in public health can result in both health-related and economic benefits. Including pharmacogenomics in public health holds promise but deserves extensive consideration. To fully realize the benefits of this technology, support is needed from private, public and governmental sectors in order to ensure the appropriateness within a society.
authors.affiliation: Charité - Universitätsmedizin, Berlin School of Public Health, Berlin, Germany.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Mette
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Mitropoulos
authors.forename: Athanassios
authors.initials: A
authors.lastname: Vozikis
authors.forename: George P
authors.initials: GP
authors.lastname: Patrinos
mesh_terms: D004358:Drug Therapy; D017723:Drug Utilization Review; D064420:Drug-Related Side Effects and Adverse Reactions; D005828:Genetics, Population; D006801:Humans; D010597:Pharmacogenetics / Q000639:trends*; D057285:Precision Medicine / Q000639:trends*; D011634:Public Health