title: Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress*.
abstract: OBJECTIVE
  Postextubation distress after a successful spontaneous breathing trial is associated with increased morbidity and mortality. Predicting postextubation distress is therefore a major issue in critically ill patients. To assess whether lung derecruitment during spontaneous breathing trial assessed by lung ultrasound is predictive of postextubation distress.
  
  
  METHODS
  Prospective study in two multidisciplinary intensive care units within University Hospital.
  
  
  METHODS
  One hundred patients were included in the study. Lung ultrasound, echocardiography, and plasma B-type natriuretic peptide levels were determined before and at the end of a 60-min spontaneous breathing trial and 4 hrs after extubation. To quantify lung aeration, a lung ultrasound score was calculated. Patients were followed up to hospital discharge.
  
  
  RESULTS
  Fourteen patients failed the spontaneous breathing trial, 86 were extubated, 57 were definitively weaned (group 1), and 29 suffered from postextubation distress (group 2). Loss of lung aeration during the successful spontaneous breathing trial was observed only in group 2 patients: lung ultrasound scores increased from 15 [13;17] to 19 [16; 21] (p < .01). End-spontaneous breathing trial lung ultrasound scores were significantly higher in group 2 than in group 1 patients: 19 [16;21] vs. 10 [7;13], respectively (p < .001) and predicted postextubation distress with an area under the receiver operating characteristic curve of 0.86. Although significantly higher in group 2, B-type natriuretic peptide and echocardiography cardiac filling pressures were not clinically helpful in predicting postextubation distress.
  
  
  CONCLUSIONS
  Lung ultrasound determination of aeration changes during a successful spontaneous breathing trial may accurately predict postextubation distress.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Multidisciplinary Intensive Care Unit, Pierre Viars, La Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, UPMC Univ, Paris, France. alexis.soummer@psl.aphp.fr
authors.forename: Alexis
authors.initials: A
authors.lastname: Soummer
authors.forename: Sébastien
authors.initials: S
authors.lastname: Perbet
authors.forename: Hélène
authors.initials: H
authors.lastname: Brisson
authors.forename: Charlotte
authors.initials: C
authors.lastname: Arbelot
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Constantin
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Rouby
mesh_terms: D000328:Adult; D060666:Airway Extubation; D004452:Echocardiography; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011446:Prospective Studies; D012372:ROC Curve; D012128:Respiratory Distress Syndrome / Q000175:diagnosis*; D015300:Ventilator Weaning
chemical_list: D020097:Natriuretic Peptide, Brain