title: Highly selective stir bar coated with dummy molecularly imprinted polymers for trace analysis of bisphenol A in milk.
abstract: A water compatible molecularly imprinted polymers (MIPs) coated stir bar for bisphenol A(BPA) was prepared with 3,3',5,5'-tetrabromobisphenol A as the dummy template molecule in this study. The dummy molecularly imprinted polymers coated stir bar (DMIPs-SB) showed better selectivity than the bars coated with polydimethylsiloxane or non-imprinted polymers when used to extract BPA and its three analogues. The saturated adsorption amount of the DMIPs coating was 3.0 times over that of the non-imprinted polymers coating. To achieve the optimum extraction performance, several parameters, including extraction and desorption time, pH value, adsorption temperature and stirring speed were investigated. The high-performance liquid chromatography combined with the DMIPs-SB was employed in the analysis of BPA in aqueous solution. The linear range of BPA concentration in aqueous medium was 0.0228-2.28 ng/mL with correlation coefficient of 0.9994 and the detection limit was about 6.84 × 10(-3)  ng/mL based on three times ratio of signal to noise. This method was directly applied to the determination of trace BPA in milk with satisfactory results.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, P R China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhan
authors.forename: Fangdi
authors.initials: F
authors.lastname: Wei
authors.forename: Guanhong
authors.initials: G
authors.lastname: Xu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cai
authors.forename: Shuhu
authors.initials: S
authors.lastname: Du
authors.forename: Xuemin
authors.initials: X
authors.lastname: Zhou
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000327:Adsorption; D000818:Animals; D001559:Benzhydryl Compounds; D002417:Cattle; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005506:Food Contamination / Q000032:analysis; D057230:Limit of Detection; D008892:Milk / Q000737:chemistry*; D054802:Molecular Imprinting; D010636:Phenols / Q000032:analysis / Q000302:isolation & purification*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; D011108:Polymers; C006780:bisphenol A; D000098826:Bisphenol A Compounds