title: Tumor necrosis factor-α gene polymorphisms in FMF and their association with amyloidosis.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by periodic provocative attacks of fever with peritonitis, pleuritis, arthritis, or eriseplemya. Tumor necrosis factor-α (TNF-α) plays an important role in the regulation of the immune response as a part of the cytokine network, including activation of macrophages and apoptosis. We investigated the possible association of TNF-α promoter -1031T/C and -308G/A polymorphisms in 86 FMF patients carrying M694 V homozygous mutation and 100 matched healthy controls both from Iranian Azeri Turks. Our data showed that patients with TNF-α -308 GG are more susceptible to the development of amyloidosis and arthritis (P value <.05). These data also showed that the frequency of TNF-α -308 A allele is considerably low among patients with amyloidosis, and it may have protective role among them (odds ratio [OR] = 0.083, χ(2) = 5.46, P value = .003). Further evaluation of this polymorphism may be important and need further studies.
authors.affiliation: Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran. jabbarpour@tabrizu.ac.ir
authors.forename: Mortaza
authors.initials: M
authors.lastname: Bonyadi
authors.forename: Salahadin
authors.initials: S
authors.lastname: Bahrami
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Jahanafrooz
authors.forename: Saeed
authors.initials: S
authors.lastname: Dastgiri
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D001168:Arthritis / Q000150:complications / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D010505:Familial Mediterranean Fever / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D005260:Female; D006801:Humans; D007492:Iran / Q000208:ethnology; D008297:Male; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha