title: Amino acid bound surfactants: a new synthetic family of polymeric monoliths opening up possibilities for chiral separations in capillary electrochromatography.
abstract: By combining a novel chiral amino-acid surfactant containing an acryloyl amide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional cross-linker and a polymerization technique, a new "one-pot" synthesis for the generation of amino-acid based polymeric monolith is realized. The method promises to open up the discovery of an amino-acid based polymeric monolith for chiral separations in capillary electrochromatography (CEC). The possibility of enhanced chemoselectivity for simultaneous separation of ephedrine and pseudoephedrine containing multiple chiral centers and the potential use of this amino-acid surfactant bound column for CEC and CEC coupled to mass spectrometric detection are demonstrated.
authors.affiliation: Center of Diagnostics and Therapeutics, Georgia State University, 50 Decatur Street, Atlanta, Georgia 30303, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wang
authors.forename: Mike
authors.initials: M
authors.lastname: Morill
authors.forename: Shahab A
authors.initials: SA
authors.lastname: Shamsi
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D053801:Capillary Electrochromatography / Q000379:methods*; D002219:Carbamates / Q000737:chemistry; D004809:Ephedrine / Q000737:chemistry / Q000302:isolation & purification; D005021:Ethylamines / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D054199:Pseudoephedrine / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000097:Acetonitriles; D000577:Amides; D000596:Amino Acids; D002219:Carbamates; D005021:Ethylamines; D011108:Polymers; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; D054199:Pseudoephedrine; D004809:Ephedrine; C016162:triethylamine; C032159:acetonitrile