title: An atlas of DNA methylomes in porcine adipose and muscle tissues.
abstract: It is evident that epigenetic factors, especially DNA methylation, have essential                 roles in obesity development. Here, using pig as a model, we investigate the                 systematic association between DNA methylation and obesity. We sample eight variant                 adipose and two distinct skeletal muscle tissues from three pig breeds living within                 comparable environments but displaying distinct fat level. We generate 1,381 Gb of                 sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a                 genome-wide DNA methylation map as well as a gene expression map for adipose and                 muscle studies. The analysis shows global similarity and difference among breeds,                 sexes and anatomic locations, and identifies the differentially methylated regions.                 The differentially methylated regions in promoters are highly associated with                 obesity development via expression repression of both known obesity-related genes                 and novel genes. This comprehensive map provides a solid basis for exploring                 epigenetic mechanisms of adipose deposition and muscle growth.
authors.affiliation: Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
authors.forename: Mingzhou
authors.initials: M
authors.lastname: Li
authors.forename: Honglong
authors.initials: H
authors.lastname: Wu
authors.forename: Zonggang
authors.initials: Z
authors.lastname: Luo
authors.forename: Yudong
authors.initials: Y
authors.lastname: Xia
authors.forename: Jiuqiang
authors.initials: J
authors.lastname: Guan
authors.forename: Tao
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authors.lastname: Wang
authors.forename: Yiren
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authors.lastname: Gu
authors.forename: Lei
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authors.lastname: Chen
authors.forename: Kai
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authors.lastname: Zhang
authors.forename: Jideng
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authors.lastname: Ma
authors.forename: Yingkai
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhong
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Shuling
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authors.lastname: Zhou
authors.forename: Zhiping
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authors.lastname: Mu
authors.forename: Xiaoyan
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authors.lastname: Wang
authors.forename: Jingjing
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authors.lastname: Qu
authors.forename: Long
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authors.lastname: Jing
authors.forename: Huiyu
authors.initials: H
authors.lastname: Wang
authors.forename: Shujia
authors.initials: S
authors.lastname: Huang
authors.forename: Na
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authors.lastname: Yi
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Dongxing
authors.initials: D
authors.lastname: Xi
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.forename: Guangliang
authors.initials: G
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Zhi
authors.initials: Z
authors.lastname: Jiang
authors.forename: Qiulei
authors.initials: Q
authors.lastname: Lang
authors.forename: Huasheng
authors.initials: H
authors.lastname: Xiao
authors.forename: Anan
authors.initials: A
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Guoqing
authors.initials: G
authors.lastname: Tang
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Mai
authors.forename: Surong
authors.initials: S
authors.lastname: Shuai
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Kui
authors.initials: K
authors.lastname: Li
authors.forename: Jinyong
authors.initials: J
authors.lastname: Wang
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Zhang
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Li
authors.forename: Haosi
authors.initials: H
authors.lastname: Chen
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Gao
authors.forename: Graham S
authors.initials: GS
authors.lastname: Plastow
authors.forename: Stephen
authors.initials: S
authors.lastname: Beck
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Xuewei
authors.initials: X
authors.lastname: Li
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D019175:DNA Methylation / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000235:genetics; D013552:Swine