title: Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients--randomized study.
abstract: OBJECTIVE
  To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP).
  
  
  METHODS
  Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. After scaling and root planing (SRP), patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3 months. The probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), approximal plaque index, glycated hemoglobin (HbA1c) level were recorded and gingival crevicular fluid (GCF) samples were collected at baseline and after 3-month therapy for the estimation of matrix metalloproteinase-8 levels.
  
  
  RESULTS
  Clinical attachment level, PD, and BOP improved significantly in both groups after therapy (P < 0.05). The statistically significant difference between the two groups after the therapy was observed only in PD in tooth sites with initial PD ≥ 4 mm (SRP + placebo: 3.41 ± 0.6 mm vs SRP + SDD: 2.92 ± 0.5 mm, P < 0.05). GCF matrix metalloproteinase-8 levels were significantly reduced only in SRP + SDD group (P < 0.01). There were no changes in HbA1c levels after therapy.
  
  
  CONCLUSIONS
  The short-term administration of SDD gives significant benefit at tooth sites with moderate disease (PD ≥ 4 mm) when compared to SRP alone in patients with diabetes and CP.
authors.affiliation: Chair and Department of Pharmacology, Medical University of Silesia, Zabrze, Poland. aplg@wp.pl
authors.forename: L
authors.initials: L
authors.lastname: Gilowski
authors.forename: P
authors.initials: P
authors.lastname: Kondzielnik
authors.forename: R
authors.initials: R
authors.lastname: Wiench
authors.forename: I
authors.initials: I
authors.lastname: Płocica
authors.forename: K
authors.initials: K
authors.lastname: Strojek
authors.forename: T F
authors.initials: TF
authors.lastname: Krzemiński
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D055113:Chronic Periodontitis / Q000150:complications* / Q000628:therapy; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry / Q000201:enzymology; D005891:Gingivitis / Q000150:complications / Q000188:drug therapy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D020784:Matrix Metalloproteinase 8 / Q000032:analysis; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000150:complications / Q000628:therapy; D010514:Periodontal Pocket / Q000150:complications / Q000628:therapy; D010919:Placebos; D016745:Root Planing / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline; D006442:Glycated Hemoglobin; D020784:Matrix Metalloproteinase 8; D010919:Placebos; C488762:MMP8 protein, human