title: Nocturnal enuresis antecedent is common in adolescents with migraine.
abstract: BACKGROUND
  Migraine and nocturnal enuresis are highly prevalent disorders with striking similarities. Both have unknown pathophysiology and are considered multifactorial, with neurobiological, genetic, and behavioral aspects involved. Interestingly, the same neurological structures thought to be involved in the pathogenesis of migraine are also thought to be involved in nocturnal enuresis. Few studies, however, have addressed these conditions as related. The aim of this study was to evaluate the antecedent of nocturnal enuresis in a large consecutive series of adolescents with migraine as compared to controls.
  
  
  METHODS
  A total of 151 subjects were evaluated; 50 had episodic migraine, 50 had chronic migraine, and 51 were control subjects. All patients were submitted to a detailed questionnaire addressing epidemiological and clinical aspects.
  
  
  RESULTS
  There was a strong correlation between the clinical history of nocturnal enuresis and the diagnosis of migraine.
  
  
  CONCLUSIONS
  Our study showed that nocturnal enuresis is a precursor of migraine and a migraine comorbid condition. These results support a pathophysiological linkage between the two conditions.
authors.affiliation: Department of Biology, Medicine and Social Sciences, Universidade do Sul de Santa Catarina, Tubarão, Brazil. linjaime@yahoo.com
authors.forename: Jaime
authors.initials: J
authors.lastname: Lin
authors.forename: Marcelo
authors.initials: M
authors.lastname: Rodrigues Masruha
authors.forename: Mario Fernando
authors.initials: MF
authors.lastname: Prieto Peres
authors.forename: Thais Soares
authors.initials: TS
authors.lastname: Cianciarullo Minett
authors.forename: Maria Sylvia
authors.initials: MS
authors.lastname: de Souza Vitalle
authors.forename: Débora
authors.initials: D
authors.lastname: Amado Scerni
authors.forename: Luiz Celso
authors.initials: LC
authors.lastname: Pereira Vilanova
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology*; D053206:Nocturnal Enuresis / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011795:Surveys and Questionnaires; D055815:Young Adult