title: Successful management of multi-focal hepatic infantile hemangioendothelioma using TACE/surgery followed by maintenance metronomic therapy.
abstract: Infantile hepatic hemangioendothelioma (IHE) is a rare angiogenic tumour with diverse clinical presentations and varied course ranging from spontaneous regression to life-threatening complications. The authors report a 2-year boy who presented with respiratory distress and was identified as a case of inoperable multi-focal hepatic IHE. He showed a transient response to trans-arterial-chemo-embolisation and liver resection but had progressive disease despite chemotherapy (prednisolone/vicristine/ifosfamide/cisplatin). Thereafter, he was successfully managed with metronomic therapy using cyclophosphamide and tamoxifen.
authors.affiliation: Pediatric Oncology Department, Tata Memorial Hospital, Mumbai, India. dr.sondhi@yahoo.co.in
authors.forename: Vishal
authors.initials: V
authors.lastname: Sondhi
authors.forename: Purna Arun
authors.initials: PA
authors.lastname: Kurkure
authors.forename: Tushar
authors.initials: T
authors.lastname: Vora
authors.forename: Shripad D
authors.initials: SD
authors.lastname: Banavali
authors.forename: S
authors.initials: S
authors.lastname: Vishwanathan
authors.forename: Seema
authors.initials: S
authors.lastname: Medhi
authors.forename: Anirudh
authors.initials: A
authors.lastname: Kulkarni
authors.forename: Sajid
authors.initials: S
authors.lastname: Quereshi
authors.forename: Brijesh
authors.initials: B
authors.lastname: Arora
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006390:Hemangioendothelioma / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D013629:Tamoxifen / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D013629:Tamoxifen; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin