title: Biological sensor based on a lateral electric field-excited resonator.
abstract: This paper describes a biological sensor based on a lateral electric field-excited resonator using an X-cut lithium niobate plate. Its potential was shown through the example of biological interaction between bacterial cells and specific bacteriophages. The detection was based on the analysis of the measured real and imaginary parts of electrical impedance for a resonator loaded by the biological suspension under study. It has been shown that the sensor is sensitive to specific interactions between bacterial cells and specific bacteriophages in a pure state as well as in the presence of extraneous microflora. The degree of electrical impedance variation resulting from the biological interaction depends on the numbers of phage particles and bacteria cells. The sensor may be used not only for the qualitative analysis of bacteria but also for their quantitative detection.
authors.affiliation: Institute of Radio Engineering and Electronics of the Russian Academy of Sciences, Saratov Branch, Saratov, Russia. zai-boris@yandex.ru
authors.forename: Boris D
authors.initials: BD
authors.lastname: Zaitsev
authors.forename: Iren E
authors.initials: IE
authors.lastname: Kuznetsova
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Shikhabudinov
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Ignatov
authors.forename: Olga I
authors.initials: OI
authors.lastname: Guliy
mesh_terms: D015806:Azospirillum brasilense / Q000737:chemistry; D001435:Bacteriophages / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D017097:Electric Impedance; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004867:Equipment Design; D004926:Escherichia coli / Q000737:chemistry / Q000821:virology; D056265:Microbial Interactions / Q000502:physiology; D009556:Niobium / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D010087:Oxides; D009556:Niobium; D014867:Water; C091692:lithium niobate