title: Effects of strontium ranelate on cortical bone collagen integrity.
abstract: OBJECTIVE
  To investigate the effect of strontium ranelate on bone collagen cross-linking in an ovariectomized rat model.
  
  
  METHODS
  Twenty-eight adult (12 weeks) albino female Wistar rats weighing between 200-250 g (n=7 per group) were divided into sham-operated, ovariectomized, prevention, and treatment groups. Animals in the prevention group were treated with strontium ranelate (500 mg/kg/day orally) for 120 days, starting immediately after ovariectomy. Animals in the treatment group were treated with strontium ranelate (500 mg/kg/day orally) for 120 days, starting 90 days after ovariectomy. At the end of the experimental period, stress, strain, and toughness of the cortical femur was measured, and collagen ultrastructure was evaluated. The study was conducted in Mersin University Biophysics Laboratory, Mersin University, Mersin, Turkey from January to May 2008.
  
  
  RESULTS
  Stress, strain, and toughness values decreased in ovariectomized, prevention, and treatment groups when compared with the sham-operated group. In this study, fiber organization was observed in the sham-operated group, whereas the parallel packing of fibrils was completely replaced by a random arrangement in the ovariectomized, prevention, and treatment groups.
  
  
  CONCLUSIONS
  Strontium ranelate treatment did not repair collagen cross-linking in ovariectomized rats.
authors.affiliation: Department of Biochemistry, Pharmacy Faculty, Mersin University, PO Box 33169, Mersin, Turkey. syalin01@hotmail.com
authors.forename: Serap
authors.initials: S
authors.lastname: Yalin
authors.forename: Ulku
authors.initials: U
authors.lastname: Comelekoglu
authors.forename: Selda
authors.initials: S
authors.lastname: Bagis
authors.forename: Nejat
authors.initials: N
authors.lastname: Yilmaz
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000187:drug effects* / Q000473:pathology; D007150:Immunohistochemistry; D009942:Organometallic Compounds / Q000494:pharmacology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013314:Stress, Mechanical; D013876:Thiophenes / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate; D003094:Collagen