title: Corticosteroid treatment of pure red cell aplasia in a patient with hepatitis A.
abstract: Secondary pure red cell aplasia (PRCA), as an extrahepatic manifestation of hepatitis A virus infection, has been reported on rare occasions. We report herein an unusual case of hepatitis A complicated by PRCA. In addition, we reviewed nine cases reported in the English literature. Our case of nonfulminant hepatitis A complicated by PRCA and hemolytic anemia was successfully treated with initial transfusion and corticosteroid therapy for 18 weeks. The patient's hematologic abnormalities and liver function tests re-normalized completely. We review clinical features and effective therapeutic strategies for this disease entity.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Young Kyung
authors.initials: YK
authors.lastname: Yoon
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Park
authors.forename: Jang Wook
authors.initials: JW
authors.lastname: Sohn
authors.forename: Min Ja
authors.initials: MJ
authors.lastname: Kim
authors.forename: Insun
authors.initials: I
authors.lastname: Kim
authors.forename: Myung Hyun
authors.initials: MH
authors.lastname: Nam
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000743:Anemia, Hemolytic / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D017707:Erythrocyte Transfusion; D005221:Fatigue / Q000209:etiology; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007565:Jaundice / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D011241:Prednisone