title: Cyclooxygenase-2 ( COX -2) gene-765G/C polymorphism and advanced-stage endometriosis in Korean women.
abstract: OBJECTIVE
  We investigated the association of COX -2 gene-765G/C polymorphism and risk of advanced-stage endometriosis in Korean women.
  
  
  METHODS
  This study consisted of 268 women with advanced-stage endometriosis and 242 control women without endometriosis in Korea. Subjects were genotyped for the -765G/C polymorphism of the COX -2 gene by RFLP-PCR analysis.
  
  
  RESULTS
  There were significant differences in the genotype distributions of the -765G/C polymorphism between patients with advanced-stage endometriosis and control subjects. The C allele for -765G/C was associated with significantly lower risk of advanced-stage endometriosis (OR, 0.14; 95% CI, 0.06-0.30).
  
  
  CONCLUSIONS
  We have demonstrated a significant genetic association between the -765G/C polymorphism and advanced-stage endometriosis in Korean women. The -765C allele may be protective against the development of the disease in Korean women.
authors.affiliation: Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Sihyun
authors.initials: S
authors.lastname: Cho
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.forename: Hyo In
authors.initials: HI
authors.lastname: Yang
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Seok Kyo
authors.initials: SK
authors.lastname: Seo
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004715:Endometriosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012720:Severity of Illness Index
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human