title: Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi.
abstract: Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and superoxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1beta).
authors.affiliation: Danylo Halytskyi Lviv National Medical University.
authors.forename: N V
authors.initials: NV
authors.lastname: Fartushok
authors.forename: O P
authors.initials: OP
authors.lastname: Khavrona
authors.forename: Yu M
authors.initials: YM
authors.lastname: Fedevych
authors.forename: O Ya
authors.initials: OY
authors.lastname: Sklyarov
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000097:blood; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D013858:Thiobarbiturates / Q000032:analysis
chemical_list: D000975:Antioxidants; D053583:Interleukin-1beta; D013858:Thiobarbiturates; D009569:Nitric Oxide; D005979:Glutathione Peroxidase; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; C029684:thiobarbituric acid