title: Dysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia.
abstract: Dementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woman with DLB developed dysphagia during treatment for tuberculous pleurisy. Oral videoendoscopic and videofluorographic swallowing examinations showed oropharyngeal dysphagia. The increased administration of levodopa successfully ameliorated dysphagia. Therefore, dysphagia was ascribed to diminished levodopa efficacy due to interaction with isoniazid. Thus, DLB patients receiving anti-tuberculous therapy should be closely examined for potential changes in swallowing and Parkinsonism.
authors.affiliation: Department of Otolaryngology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama, Japan. m-ohki@umin.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ohki
authors.forename: Niro
authors.initials: N
authors.lastname: Tayama
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003680:Deglutition Disorders / Q000139:chemically induced* / Q000188:drug therapy; D015259:Dopamine Agents / Q000627:therapeutic use; D004347:Drug Interactions; D004724:Endoscopy; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D007980:Levodopa / Q000627:therapeutic use; D020961:Lewy Body Disease / Q000150:complications*; D014396:Tuberculosis, Pleural / Q000188:drug therapy*; D014741:Video Recording
chemical_list: D000995:Antitubercular Agents; D015259:Dopamine Agents; D007980:Levodopa; D007538:Isoniazid