title: The effect of the flavonol morin on adhesion and aggregation of Streptococcus pyogenes.
abstract: The effect of the flavonol morin on Streptococcus pyogenes biofilm growth was determined using a static biofilm model, in which reduced biofilm biomass was observed in the presence of morin, suggesting that morin inhibited biofilm development. Morin at concentrations exceeding 225 μM had the greatest impact on biofilm biomass causing reductions of up to 65%, which was found to be statistically significant. Morin was also shown to induce rapid bacterial aggregation. Approximately 55% of S. pyogenes in liquid suspension aggregated when incubated with morin at concentrations of 275 and 300 μM for 120 min, compared to the control group in which only 10% of the cells aggregated, this was also shown to be statistically significant.
authors.affiliation: Cardiff Metropolitan University, Cardiff, UK.
authors.forename: Angharad E
authors.initials: AE
authors.lastname: Green
authors.forename: Richard S
authors.initials: RS
authors.lastname: Rowlands
authors.forename: Rose A
authors.initials: RA
authors.lastname: Cooper
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Maddocks
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion; D058491:Bacterial Load; D018441:Biofilms / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D050296:Microbial Viability; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D047309:Flavones
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; C008548:morin; D047309:Flavones