title: Interleukin 1 gene cluster SNPs (rs1800587, rs1143634) influences post-orthodontic root resorption in endodontic and their contralateral vital control teeth differently.
abstract: OBJECTIVE
  To investigate whether the genetic variants of the interleukin-1 gene cluster (IL1) are associated with a possible genetically induced variability in post-orthodontic external apical root resorption (EARR) in root filled teeth and their control counterparts with vital pulps.
  
  
  METHODS
  One hundred and forty-six maxillary premolars were evaluated radiographically following orthodontic treatment. Genetic screening was performed on orthodontic patients for two single-nucleotide polymorphisms (SNPs: rs1800587 and rs1143634) in the IL1 gene cluster. Subjects were divided into two groups according to the presence or absence of radiographic post-orthodontic EARR (>2 mm) in root filled teeth and their controls with vital pulps. Logistic regression analysis was performed to obtain an adjusted estimation between EARR and IL1 polymorphisms. Allelic frequencies, genotype distributions, and adjusted odds ratio (OR), at 95% confidence interval, were also calculated.
  
  
  RESULTS
  Whilst no clear statistical association was found for gene variations in IL1A, a sound association was found in the comparative analysis of subjects homozygous [2/2(TT)] for the IL1B gene, which resulted in a two times increased risk of suffering post-orthodontic EARR in root filled teeth [OR, 2.032 (P = 0.031); CI,1.99-14.77] when compared with their controls with vital pulps. There was, however, a shared predisposition to EARR in controls with vital pulps and root filled teeth of subjects homozygous for allele 1 [OR, 5.05 (P = 0.002)] and [OR, 2.77 (P = 0.037)], respectively.
  
  
  CONCLUSIONS
  Genetic variations in the interleukin-1β gene (rs1143634) predispose root filled teeth to EARR for matched pairs secondary to orthodontic treatment in a different way from their control teeth with vital pulps in subjects homozygous for allele 2 [2/2(TT)].
authors.affiliation: Department of Orthodontics, School of Dentistry, University of Seville, Seville, Spain. brpi@us.es
authors.forename: A
authors.initials: A
authors.lastname: Iglesias-Linares
authors.forename: R M
authors.initials: RM
authors.lastname: Yañez-Vico
authors.forename: S
authors.initials: S
authors.lastname: Ballesta
authors.forename: E
authors.initials: E
authors.lastname: Ortiz-Ariza
authors.forename: A
authors.initials: A
authors.lastname: Mendoza-Mendoza
authors.forename: E
authors.initials: E
authors.lastname: Perea
authors.forename: E
authors.initials: E
authors.lastname: Solano-Reina
mesh_terms: D000293:Adolescent; D000328:Adult; D001641:Bicuspid; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003799:Dental Stress Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008437:Maxilla; D005810:Multigene Family / Q000235:genetics*; D016017:Odds Ratio; D009971:Orthodontics, Corrective / Q000009:adverse effects*; D010512:Periodontal Index; D020641:Polymorphism, Single Nucleotide; D012389:Root Canal Obturation / Q000009:adverse effects; D012391:Root Resorption / Q000209:etiology* / Q000235:genetics*; D019553:Tooth, Nonvital / Q000235:genetics*; D055815:Young Adult
chemical_list: D053582:Interleukin-1alpha; D053583:Interleukin-1beta