title: Aggregative multicellularity evolved independently in the eukaryotic supergroup Rhizaria.
abstract: Multicellular forms of life have evolved many times, independently giving rise to a diversity of organisms such as animals, plants, and fungi that together comprise the visible biosphere. Yet multicellular life is far more widespread among eukaryotes than just these three lineages. A particularly common form of multicellularity is a social aggregative fruiting lifestyle whereby individual cells associate to form a "fungus-like" sorocarp. This complex developmental process that requires the interaction of thousands of cells working in concert was made famous by the "cellular slime mold"Dictyostelium discoideum, which became an important model organism. Although sorocarpic protistan lineages have been identified in five of the major eukaryote groups, the ubiquitous and globally distributed species Guttulinopsis vulgaris has eluded proper classification. Here we demonstrate, by phylogenomic analyses of a 159-protein data set, that G. vulgaris is a member of Rhizaria and is thus the first member of this eukaryote supergroup known to be capable of aggregative multicellularity.
authors.affiliation: Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada. protist@live.com
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Brown
authors.forename: Martin
authors.initials: M
authors.lastname: Kolisko
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Silberman
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Roger
mesh_terms: D000220:Adaptation, Biological / Q000502:physiology*; D001483:Base Sequence; D001499:Bayes Theorem; D005075:Biological Evolution; D018076:DNA, Complementary / Q000235:genetics; D023281:Genomics / Q000379:methods; D016013:Likelihood Functions; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D056901:Rhizaria / Q000145:classification / Q000166:cytology* / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D018076:DNA, Complementary