title: Angiogenetic pathway as a therapeutic target in renal cell carcinoma.
abstract: For several decades, metastatic renal cell carcinoma (mRCC) was considered resistant to therapy and thus linked to poor prognosis. Recent years have seen a complete revolution of the therapeutic landscape, with the introduction of new target therapies that have radically changed treatment strategies in this setting. These new agents have proved to be effective if directed mainly against the angiogenic pathway. The vascular endothelial growth factor family is, in fact, the main target of a number of new drugs, such as monoclonal antibodies and different generations of tyrosine-kinase inhibitors that are currently approved or in different stages of clinical trial for the treatment of mRCC patients.
authors.affiliation: Medical Oncology Clinic, AOU Ospedali Riuniti, Polytechnic University of the Marche Region, Ancona, Italy.
authors.forename: Maristella
authors.initials: M
authors.lastname: Bianconi
authors.forename: Mario
authors.initials: M
authors.lastname: Scartozzi
authors.forename: Luca
authors.initials: L
authors.lastname: Faloppi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bittoni
authors.forename: Elena
authors.initials: E
authors.lastname: Maccaroni
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giampieri
authors.forename: Michela
authors.initials: M
authors.lastname: Del Prete
authors.forename: Luciano
authors.initials: L
authors.lastname: Burattini
authors.forename: Stefano
authors.initials: S
authors.lastname: Cascinu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000188:drug therapy*; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*
chemical_list: D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors