title: Optic nerve head quantification in idiopathic intracranial hypertension by spectral domain OCT.
abstract: OBJECTIVE
  To evaluate 3D spectral domain optical coherence tomography (SDOCT) volume scans as a tool for quantification of optic nerve head (ONH) volume as a potential marker for treatment effectiveness and disease progression in idiopathic intracranial hypertension (IIH).
  
  
  METHODS
  Cross-sectional pilot trial comparing 19 IIH patients and controls matched for gender, age and body mass index. Each participant underwent SDOCT. A custom segmentation algorithm was developed to quantify ONH volume (ONHV) and height (ONHH) in 3D volume scans.
  
  
  RESULTS
  Whereas peripapillary retinal nerve fiber layer thickness did not show differences between controls and IIH patients, the newly developed 3D parameters ONHV and ONHH were able to discriminate between controls, treated and untreated patients. Both ONHV and ONHH measures were related to levels of intracranial pressure (ICP).
  
  
  CONCLUSIONS
  Our findings suggest 3D ONH measures as assessed by SDOCT as potential diagnostic and progression markers in IIH and other disorders with increased ICP. SDOCT may promise a fast and easy diagnostic alternative to repeated lumbar punctures and could therefore ease monitoring of treatment or disease progression.
authors.affiliation: NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
authors.forename: Falko
authors.initials: F
authors.lastname: Kaufhold
authors.forename: Ella Maria
authors.initials: EM
authors.lastname: Kadas
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmidt
authors.forename: Hagen
authors.initials: H
authors.lastname: Kunte
authors.forename: Jan
authors.initials: J
authors.lastname: Hoffmann
authors.forename: Hanna
authors.initials: H
authors.lastname: Zimmermann
authors.forename: Timm
authors.initials: T
authors.lastname: Oberwahrenbrock
authors.forename: Lutz
authors.initials: L
authors.lastname: Harms
authors.forename: Konrad
authors.initials: K
authors.lastname: Polthier
authors.forename: Alexander U
authors.initials: AU
authors.lastname: Brandt
authors.forename: Friedemann
authors.initials: F
authors.lastname: Paul
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009898:Optic Disk / Q000503:physiopathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D010865:Pilot Projects; D011559:Pseudotumor Cerebri / Q000175:diagnosis / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult