title: The diagnostic accuracy of static posturography in predicting accidental falls in people with multiple sclerosis.
abstract: BACKGROUND
  Quantitative posturography has been reported as a reliable tool to measure balance in people with multiple sclerosis (MS). However, data on its diagnostic accuracy in predicting the occurrence of falls are lacking.
  
  
  OBJECTIVE
  To determine sensitivity, specificity, predictive values, and accuracy of posturography in detecting falls in MS subjects over a 3-month follow-up period.
  
  
  METHODS
  . One hundred consecutive patients with MS were tested by the Berg Balance Scale (BBS) and by static posturography on a monoaxial platform. Participants recorded the occurrence of accidental falls for the next 3 months. Abnormal cutoff values for static standing balance measures were set at 2 standard deviations above the mean values obtained from 50 healthy controls (HC). The diagnostic accuracy of the BBS and static posturography was analyzed with respect to the prospectively collected data on the occurrence of falls.
  
  
  RESULTS
  Posturometric measures in participants with MS were significantly worse than in HC (all P values <.0001); however, only the center of pressure (COP) path with open eyes condition had substantial test-retest reliability. Static posturography was more sensitive (88% vs 37%) and accurate (75% vs 63%), but slightly less specific (67% vs 81%), than the BBS in predicting accidental falls. A logistic regression analysis revealed that the worse the COP path, the greater the risk for accidental falls (odds ratio = 1.08; P < .0001), even after adjusting for sex, age, disease duration, body mass index, MS subtype, Expanded Disability Status Scale, and BBS score.
  
  
  CONCLUSIONS
  The COP path measurement in static position is a sensitive and accurate tool to identify people with MS who are at risk of accidental falls.
authors.affiliation: Department of Neurology and Psychiatry, Multiple Sclerosis Centre, S. Andrea Hospital Sapienza University, Rome, Italy. luca.prosperini@uniroma1.it
authors.forename: Luca
authors.initials: L
authors.lastname: Prosperini
authors.forename: Deborah
authors.initials: D
authors.lastname: Fortuna
authors.forename: Costanza
authors.initials: C
authors.lastname: Giannì
authors.forename: Laura
authors.initials: L
authors.lastname: Leonardi
authors.forename: Carlo
authors.initials: C
authors.lastname: Pozzilli
mesh_terms: D000058:Accidental Falls; D000328:Adult; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D009460:Neurologic Examination; D004856:Postural Balance / Q000502:physiology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult