title: The contribution of the Y chromosome to hybrid male sterility in house mice.
abstract: Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of both. We investigated the contribution of the M. musculus domesticus Y chromosome to hybrid male sterility in a cross between wild-derived strains in which males with a M. m. musculus X chromosome and M. m. domesticus Y chromosome are partially sterile, while males from the reciprocal cross are reproductively normal. We used eight X introgression lines to combine different X chromosome genotypes with different Y chromosomes on an F1 autosomal background, and we measured a suite of male reproductive traits. Reproductive deficits were observed in most F1 males, regardless of Y chromosome genotype. Nonetheless, we found evidence for a negative interaction between the M. m. domesticus Y and an interval on the M. m. musculus X that resulted in abnormal sperm morphology. Therefore, although F1 male sterility appears to be caused mainly by X-autosome incompatibilities, X-Y incompatibilities contribute to some aspects of sterility.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA. pollyc@email.arizona.edu
authors.forename: Polly
authors.initials: P
authors.lastname: Campbell
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Good
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Dean
authors.forename: Priscilla K
authors.initials: PK
authors.lastname: Tucker
authors.forename: Michael W
authors.initials: MW
authors.lastname: Nachman
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005838:Genotype; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D051379:Mice; D010641:Phenotype; D040641:Quantitative Trait Loci; D012098:Reproduction / Q000235:genetics; D013094:Spermatozoa / Q000378:metabolism / Q000473:pathology; D014960:X Chromosome; D014998:Y Chromosome