title: Treatment of chronic myelomonocytic leukemia with 5-Azacitidine: a case series and literature review.
abstract: Chronic myelomonocytic leukemia (CMML) is a clinically heterogeneous disease, with no standard treatment. We present the outcome of ten patients diagnosed with CMML and treated with AZA in our institutions between 2005 and 2010. All patients were transfusion dependent at the time of initiation of therapy. The overall response rate was 60%. Responses were obtained in 2/3 of the patients with proliferative CMML. The median survival from start of therapy was 20 months. AZA treatment was well-tolerated and associated with a significant response rate in all forms of the disease.
authors.affiliation: School of Medicine, Flinders University, South Australia, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Thorpe
authors.forename: Ana
authors.initials: A
authors.lastname: Montalvão
authors.forename: Francesca
authors.initials: F
authors.lastname: Pierdomenico
authors.forename: Filipa
authors.initials: F
authors.lastname: Moita
authors.forename: António
authors.initials: A
authors.lastname: Almeida
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001374:Azacitidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine