title: Receptors of garlic (Allium sativum) lectins and their role in insecticidal action.
abstract: Garlic (Allium sativum) lectins are promising candidate molecules for the protection against chewing (lepidopteran) as well as sap sucking (homopteran) insect pests. Molecular mechanism of toxicity and interaction of lectins with midgut receptor proteins has been described in many reports. Lectins show its effect right from sensory receptors of mouth parts by disrupting the membrane integrity and food detection ability. Subsequently, enter into the gut lumen and interact with midgut glycosylated proteins like alkaline phosphatase (ALP), aminopeptidase-N (APN), cadherin-like proteins, polycalins, sucrase, symbionin and others. These proteins play critical role in life cycle of insect directly or indirectly. Lectins interfere with the activity of these proteins and causes physiological disorders leading to the death of insects. Lectins further transported across the insect gut, accumulated in various body parts (like haemolymph and ovary) and interact with intracellular proteins like symbionin and cytochrome p450. Binding with cytochrome p450 (which involve in ecdysone synthesis) might interfere in the development of insects, which results in growth retardation and pre-mature death.
authors.affiliation: CSIR-National Botanical Research Institute, Council of Scientific and Industrial Research, Rana Pratap Marg, Lucknow, UP 226001, India.
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Upadhyay
authors.forename: Pradhyumna K
authors.initials: PK
authors.lastname: Singh
mesh_terms: D000818:Animals; D005737:Garlic / Q000737:chemistry*; D006023:Glycoproteins / Q000378:metabolism; D019476:Insect Proteins; D007313:Insecta / Q000187:drug effects*; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D010572:Pest Control, Biological; D037121:Plant Lectins / Q000737:chemistry / Q000494:pharmacology*; D030821:Plants, Genetically Modified; D011134:Polysaccharides / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D011975:Receptors, Mitogen / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D019476:Insect Proteins; D007306:Insecticides; D037121:Plant Lectins; D011134:Polysaccharides; D011975:Receptors, Mitogen