title: Improved ion mobility resolving power with increased buffer gas pressure.
abstract: Security and military applications of analytical techniques demand a small, rugged, reliable instrument that has traditionally been served well by atmospheric pressure ion mobility spectrometry (IMS) systems. Modern threats stipulate these instruments must reliably operate in increasingly complex environments. Previous work has demonstrated that increasing the pressure of an IMS drift tube has the potential to increase the resolving power of IMS, but operation at low temperatures resulted in a leveling of the measured resolving power as a function of pressure. By creating a novel aperture grid/Faraday plate design, a high-pressure IMS (HPIMS) system has been created that maintains a resolving power efficiency of 80% regardless of the pressure applied to the cell. This allows previously unattainable resolving powers to be achieved utilizing a small (10.7 cm) IMS cell. Using high pressure, a stand-alone IMS cell of 10.7 cm length has demonstrated a resolving power of 102 when operated at 2.5 atm. An increase in peak-to-peak resolution was also noted as pressure increased. Finally, the slope of the resulting inverse mobility/pressure curve for a single analyte has been shown to be proportional to the collision-cross-section of the analyte of interest, providing a novel method for the calculation of collision-cross-section of target ions from the HPIMS data.
authors.affiliation: Washington State University, Department of Chemistry, P.O. Box 644630, Pullman, Washington 99164, United States.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Davis
authors.forename: Kristopher F
authors.initials: KF
authors.lastname: Grows
authors.forename: William F
authors.initials: WF
authors.lastname: Siems
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Hill