title: TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction.
abstract: Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP. Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD. In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP. Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP. TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier.
authors.affiliation: Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Dang
authors.forename: Yao
authors.initials: Y
authors.lastname: Shen
authors.forename: Kai
authors.initials: K
authors.lastname: Yin
authors.forename: Jianxin
authors.initials: J
authors.lastname: Zhang