title: Effect of platelet concentrate on quality of life after periradicular surgery: a randomized clinical study.
abstract: BACKGROUND
  Control of postoperative discomfort might enhance the patient's quality of life and treatment acceptance. The aim of the present randomized single-blind study was to evaluate whether the use of platelet concentrate during endodontic surgery might have a favorable impact on pain and other factors related to patient's quality of life during the first week after surgery.
  
  
  METHODS
  Eighteen patients with periapical lesion were treated with modern endodontic surgical procedure (control group). In another 18 patients, in adjunct to surgical procedure, platelet concentrate was applied on the root end in liquid form, within the bone defect in clot form, and over the suture in liquid form (test group). All patients completed a questionnaire for evaluation of main symptoms and daily activities during the first week after surgery. The outcomes of the questionnaires of the 2 groups were statistically compared.
  
  
  RESULTS
  The test group showed significantly less pain and swelling, fewer analgesics taken, and improved functional activities as compared with the control group.
  
  
  CONCLUSIONS
  The adjunct of platelet concentrate to the endodontic surgical procedure produced significant beneficial effect to patients' quality of life during the early postoperative stage.
authors.affiliation: IRCCS Galeazzi Orthopaedic Institute, Dental Clinic, Centro di Ricerca per la Salute Orale (CRSO), Department of Health Technologies, University of Milan, Milan, Italy. massimo.delfabbro@unimi.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Fabbro
authors.forename: Valentina
authors.initials: V
authors.lastname: Ceresoli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lolato
authors.forename: Silvio
authors.initials: S
authors.lastname: Taschieri
mesh_terms: D000328:Adult; D005260:Female; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control* / Q000523:psychology; D010483:Periapical Diseases / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011788:Quality of Life; D012184:Retrograde Obturation; D012390:Root Canal Therapy / Q000523:psychology*; D016037:Single-Blind Method; D011795:Surveys and Questionnaires
chemical_list: D006133:Growth Substances