title: The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
abstract: Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We assess the reciprocal synergistic effects of AM and AMBP-1 and make suggestions for the design of a novel combination neurotherapy devoid of the potential hypotensive effects of AM while optimizing its neuroprotective property.
authors.affiliation: Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, North Shore-LI Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: Cletus
authors.initials: C
authors.lastname: Cheyuo
authors.forename: Weng-Lang
authors.initials: WL
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D053607:Adrenomedullin / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism; D017242:Complement Factor H / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D053607:Adrenomedullin; D017242:Complement Factor H; D018696:Neuroprotective Agents; C493495:CFH protein, human