title: HER2-positive male breast cancer with thyroid cancer: an institutional report and review of literature.
abstract: We report a rare finding of two male breast cancer patients with HER2-positive breast cancer who also developed thyroid cancer. We reviewed 45 male breast cancer patients treated in our institution from 2003 to 2008. Only five male breast cancer patients were HER2-positive. In reviewing the published data, we found no cases of thyroid cancer and concurrent breast cancer in men. However, breast cancer and thyroid cancer have shown close association in women. This finding therefore provokes speculation as to whether we should investigate whether women with HER2-positive breast cancer are at a higher risk for thyroid cancer. Although this observation seems to be clinically prevalent, publications are sparse in clinical research areas linking thyroid cancer to breast cancer.
authors.affiliation: Department of Women’s Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Bardhan
authors.forename: Marilyn M
authors.initials: MM
authors.lastname: Bui
authors.forename: Susan
authors.initials: S
authors.lastname: Minton
authors.forename: Loretta
authors.initials: L
authors.lastname: Loftus
authors.forename: W Bradford
authors.initials: WB
authors.lastname: Carter
authors.forename: Christine
authors.initials: C
authors.lastname: Laronga
authors.forename: Roohi
authors.initials: R
authors.lastname: Ismail-Khan
mesh_terms: D000047:Academies and Institutes; D000368:Aged; D018567:Breast Neoplasms, Male / Q000150:complications* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D013194:Staining and Labeling; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human