title: Efficacy of florfenicol injection in the treatment of Mycoplasma hyopneumoniae induced respiratory disease in pigs.
abstract: This study investigated the efficacy of a single intramuscular injection of a new formulation of florfenicol to treat clinical respiratory disease following experimental Mycoplasma hyopneumoniae infection. M. hyopneumoniae-free piglets were allocated to three groups, namely, a treatment group (TG) and a positive control group (PCG), which were both inoculated endotracheally with a highly virulent isolate of M. hyopneumoniae, and a negative control group. At the onset of clinical disease, the TG received a single injection of florfenicol (30 mg/kg). All pigs were euthanased 4 weeks post-infection. Clinical symptoms were significantly reduced in the TG in comparison with the PCG. Average daily gain, feed conversion ratio, mortality and lung lesions were improved in the TG compared to the PCG, but the differences were not statistically significant.
authors.affiliation: Department of Reproduction Obstetrics and Herd Health, Ghent University, Faculty of Veterinary Medicine, Salisburylaan 133, B-9820 Merelbeke, Belgium. ruben.delpozosacristan@ugent.be
authors.forename: R
authors.initials: R
authors.lastname: Del Pozo Sacristán
authors.forename: J
authors.initials: J
authors.lastname: Thiry
authors.forename: K
authors.initials: K
authors.lastname: Vranckx
authors.forename: A
authors.initials: A
authors.lastname: López Rodríguez
authors.forename: K
authors.initials: K
authors.lastname: Chiers
authors.forename: F
authors.initials: F
authors.lastname: Haesebrouck
authors.forename: E
authors.initials: E
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Maes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D007273:Injections, Intramuscular / Q000662:veterinary; D045705:Mycoplasma hyopneumoniae / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D045729:Pneumonia of Swine, Mycoplasmal / Q000188:drug therapy*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013552:Swine; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol