title: Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function.
abstract: The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product.
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Hall
authors.forename: Erkin
authors.initials: E
authors.lastname: Kuru
authors.forename: Michael S
authors.initials: MS
authors.lastname: VanNieuwenhze
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D060327:Solid-Phase Synthesis Techniques
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C056790:katanosin B