title: Synthesis, spectral studies and antimicrobial activities of some 2-naphthyl pyrazoline derivatives.
abstract: A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80%. The synthesized pyrazolines were characterized by their physical constants, IR, (1)H, (13)C and MS spectra. From the IR and NMR spectra the C=N (cm(-1)) stretches, the pyrazoline ring proton chemical shifts (ppm) of δ(Ha), H(b) and H(c) and also the carbon chemical shifts (ppm) of δC=N are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied.
authors.affiliation: PG & Research Department of Chemistry, Government Arts College, C-Mutlur 608102, Chidambaram, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Sakthinathan
authors.forename: G
authors.initials: G
authors.lastname: Vanangamudi
authors.forename: G
authors.initials: G
authors.lastname: Thirunarayanan
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D011720:Pyrazoles