title: Aristolactam-type alkaloids from Orophea enterocarpa and their cytotoxicities.
abstract: A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC(50) values of 1.68 and 1.32 μM, respectively.
authors.affiliation: Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand.
authors.forename: Sanchai
authors.initials: S
authors.lastname: Nayyatip
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand.
authors.forename: Pak
authors.initials: P
authors.lastname: Thaichana
authors.affiliation: Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand.
authors.forename: Mongkol
authors.initials: M
authors.lastname: Buayairaksa
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 53000, Thailand.
authors.forename: Wirote
authors.initials: W
authors.lastname: Tuntiwechapikul
authors.affiliation: Department of Chemistry, Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 53000, Thailand.
authors.forename: Puttinan
authors.initials: P
authors.lastname: Meepowpan
authors.affiliation: The Forest Herbarium, Department of National Park, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10220, Thailand.
authors.forename: Narong
authors.initials: N
authors.lastname: Nuntasaen
authors.affiliation: Laboratory of Natural Products, Center for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand.
authors.forename: Wilart
authors.initials: W
authors.lastname: Pompimon
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D029061:Annonaceae / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D055808:Drug Discovery; D006801:Humans; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D007769:Lactams / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D026121:Indole Alkaloids; D007769:Lactams; D010616:Phenanthrenes; D010936:Plant Extracts; C414695:stigmalactam