title: Non-synonymous SNPs in MC1R gene are associated with the extended black variant in domestic ducks (Anas platyrhynchos).
abstract: In this study, we performed a sequence characterization of the duck melanocortin 1 receptor (alpha-melanocyte stimulating hormone receptor) (MC1R) gene to analyze the relationship between MC1R polymorphism and the extended black variant in domestic ducks based on the extended black (E) and non-extended black (e(+) ) allele hypothesis of the duck MC1R gene. Both c.52G>A and c.376G>A substitutions are highly associated with the duck extended black variant (P < 0.01), but the novel c.52G>A substitution is more of a fit for the allele hypothesis of the duck MC1R gene.
authors.affiliation: Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, P.R. China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Yu
authors.forename: Cui
authors.initials: C
authors.lastname: Wang
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Xin
authors.forename: Shijun
authors.initials: S
authors.lastname: Li
authors.forename: Yanping
authors.initials: Y
authors.lastname: Feng
authors.forename: Xiuli
authors.initials: X
authors.lastname: Peng
authors.forename: Yanzhang
authors.initials: Y
authors.lastname: Gong
mesh_terms: D000818:Animals; D001483:Base Sequence; D004372:Ducks / Q000235:genetics* / Q000502:physiology; D005787:Gene Frequency; D056726:Genetic Association Studies; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010641:Phenotype; D010858:Pigmentation / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000662:veterinary
chemical_list: D044102:Receptor, Melanocortin, Type 1