title: On the road to combinations of targeted therapies: PPM1H phosphatase as a suppressor of trastuzumab resistance.
abstract: Lee-Hoeflich and colleagues use RNA interference screening to identify the serine/threonine phosphatase PPM1H as an inhibitor of trastuzumab resistance in vitro. This finding extends the molecular portrait of trastuzumab-resistant cells and provides a rationale when searching for potential therapeutic targets among regulators of PPM1H and/or its substrates.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. bentires@fmi.ch
authors.forename: Nicola
authors.initials: N
authors.lastname: Aceto
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bentires-Alj
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics*; D005260:Female; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000235:genetics* / Q000378:metabolism*; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D050760:Cyclin-Dependent Kinase Inhibitor p27; C521058:PPM1H protein, human; D010749:Phosphoprotein Phosphatases; D000068878:Trastuzumab