title: CD158k/KIR3DL2 and NKp46 are frequently expressed in transformed mycosis fungoides.
abstract: Malignant Sezary cells express the natural killer (NK) receptors KIR3DL2 (CD158k) and Nkp46 and may co-express activating killer immunoglobulin-like receptors (KIR) that may participate to neoplastic T-cell activation through the JNK pathway. Little is known regarding NK receptor expression in other cutaneous T-cell lymphomas. We studied the expression of KIR and natural cytotoxicity receptor (NCR) transcripts, and KIR3DL1/2 at the protein level, in 16 skin biopsies from 10 patients with transformed mycosis fungoides (tMF). Some KIR and NCR transcripts were found in all cases, with various repertoires. Two to nine different KIR receptors were expressed in a single biopsy. Among them, KIR3DL2 was the most frequent, with the highest level of expression in quantitative analyses and correlated with in situ protein expression, while phosphorylated JNK was never detected. Among NCR, NKp46 was expressed in all investigated cases. The role of KIR3DL2 and NKp46 in tMF oncogenesis remains to be studied.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ortonne
authors.forename: Sabine
authors.initials: S
authors.lastname: Le Gouvello
authors.forename: Reka
authors.initials: R
authors.lastname: Tabak
authors.forename: Anne
authors.initials: A
authors.lastname: Marie-Cardine
authors.forename: Julie
authors.initials: J
authors.lastname: Setiao
authors.forename: François
authors.initials: F
authors.lastname: Berrehar
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nghe-Tang
authors.forename: Nadine
authors.initials: N
authors.lastname: Martin
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.forename: Armand
authors.initials: A
authors.lastname: Bensussan
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D009182:Mycosis Fungoides / Q000378:metabolism*; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000378:metabolism*; D054343:Receptors, KIR2DL2 / Q000378:metabolism*; D054347:Receptors, KIR3DL2 / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
chemical_list: C515077:KIR2DL2 protein, human; C515084:KIR3DL2 protein, human; C112260:NCR1 protein, human; D055627:Natural Cytotoxicity Triggering Receptor 1; D054343:Receptors, KIR2DL2; D054347:Receptors, KIR3DL2