title: Hypothesis for resolution of diabetes after sleeve gastrectomy.
abstract: Sleeve gastrectomy improves glucose metabolism as effective as Roux-en Y gastric bypass. The underlying mechanism is still not clear. We hypothesized that inhibition of GOAT activity was one therapeutic consequence of SG, and a status of low ghrelin level with low AG: UAG ratio might be an optimal gastrointestinal hormone profile for the remission of T2DM.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Da-qiao
authors.initials: DQ
authors.lastname: Zhu
authors.forename: Ming
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000217:Acyltransferases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000517:prevention & control*; D005743:Gastrectomy / Q000295:instrumentation / Q000379:methods*; D054439:Ghrelin / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D012074:Remission Induction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D054439:Ghrelin; D000217:Acyltransferases; C542776:MBOAT4 protein, human; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D005947:Glucose