title: Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress.
abstract: An individual's behavior is generally based on genetic blueprint and previous experiences. A coping strategy, affected by personal interpretation of past events, can be determined by behavioral controllability of stress. In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress. Rats were exposed to stress via inescapable and unpredictable footshocks on PNDs 14 and 90. Coping strategies to stress were also measured. Hippocampal mGluR5 was found to be linked to the behavioral coping strategy, as it increased in rats that showed helplessness behavior (HL (+) group) and decreased in those that did not (HL (-) group). Also, the HL (+) group showed a lack of adaptation in a novel environment but the HL (-) group did not. The results suggest that mGluR5 has a pivotal role in the controllability-based coping strategy. Hippocampal mGluR5 could be a target molecule in the manipulation of neuropsychiatric conditions for which maladaptation is a part of behavioral consequences.
authors.affiliation: Department of Pharmacology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Yeong Shin
authors.initials: YS
authors.lastname: Yim
authors.forename: Jinu
authors.initials: J
authors.lastname: Lee
authors.forename: Gun-Tae
authors.initials: GT
authors.lastname: Kim
authors.forename: Teresa
authors.initials: T
authors.lastname: Song
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Kim
authors.forename: Dong Goo
authors.initials: DG
authors.lastname: Kim
mesh_terms: D000223:Adaptation, Psychological; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D006380:Helplessness, Learned; D006624:Hippocampus / Q000378:metabolism*; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C578937:Grm5 protein, rat; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate