title: Antifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticles.
abstract: OBJECTIVE
  This study evaluated the antifungal and physical characteristics of denture base acrylic combined with silver nanoparticles.
  
  
  METHODS
  Polymerized denture acrylic disc specimens containing 0 (control), 1.0, 5.0, 10.0, 20.0 and 30.0 wt% of silver nanoparticles were placed on separate culture plate dish and 100 ìL samples of yeast suspension of Candida albicans strain were inoculated on each specimens and incubated at 37°C, for 24 h. The antifungal effects were evaluated as a number of viable cells in retrieved fungal suspension. To characterize physical aspects, specimens were tested for elution of silver cation (Ag(+)) at 24 h and 30th day, thermal analysis (TG/DTA), scanning electron microscope and energy dispersed X-ray analysis (SEM/EDX) and color stability.
  
  
  RESULTS
  Significant reduced CFU was exhibited at 20.0 and 30.0 wt% of silver nanoparticles incorporated (p < 0.01) and Ag(+) elution from specimens (maximum 0.356 ± 0.11 mg/L) contributed little to the antifungal activity considering MIC of Ag(+) in this study (3.0 mg/L). The successful synthesis of modified denture acrylic containing silver nanoparticles was accessed by TG/DTA and EDX analysis.
  
  
  CONCLUSIONS
  The modified denture base acrylic combined with silver nanoparticles displayed antifungal properties and acted like latent antifungal material itself with low-releasing Ag(+), however, the improvement of poor color stability was still required.
authors.affiliation: Department of Dentistry, College of Medicine, Keimyung University, Dongsan-dong, Jung-gu, Daegu, Korea. nkyp@dsmc.or.kr
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Nam
authors.forename: Cheong-Hee
authors.initials: CH
authors.lastname: Lee
authors.forename: Chul-Jae
authors.initials: CJ
authors.lastname: Lee
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003116:Color; D003124:Colorimetry; D003764:Dental Materials / Q000737:chemistry*; D003819:Denture Bases; D004055:Differential Thermal Analysis; D004058:Diffusion; D006801:Humans; D008422:Materials Testing; D050296:Microbial Viability / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry / Q000494:pharmacology*; D013052:Spectrometry, X-Ray Emission; D013053:Spectrophotometry; D013054:Spectrophotometry, Atomic; D013499:Surface Properties; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D000935:Antifungal Agents; D003764:Dental Materials; C040291:Lucitone; D012835:Silver Nitrate