title: Curved biodegradable microneedles for vascular drug delivery.
abstract: Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.
authors.affiliation: School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
authors.forename: Chang Kuk
authors.initials: CK
authors.lastname: Choi
authors.forename: Jin Bum
authors.initials: JB
authors.lastname: Kim
authors.forename: Eui Hwa
authors.initials: EH
authors.lastname: Jang
authors.forename: Young-Nam
authors.initials: YN
authors.lastname: Youn
authors.forename: Won Hyoung
authors.initials: WH
authors.lastname: Ryu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D001808:Blood Vessels / Q000502:physiology*; D004285:Dogs; D016503:Drug Delivery Systems / Q000295:instrumentation*; D008845:Microinjections / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009339:Needles; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials