title: Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study.
abstract: There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3-β-D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty-six episodes of bacteraemia that occurred in high-risk haematological patients were included in our study. Consecutive BG levels >80 pg ml(-1) were required for test positivity. Only 2 of 26 patients were BG positive - both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients.
authors.affiliation: Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic. zracil@fnbrno.cz
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Racil
authors.forename: Iva
authors.initials: I
authors.lastname: Kocmanova
authors.forename: Martina
authors.initials: M
authors.lastname: Toskova
authors.forename: Jana
authors.initials: J
authors.lastname: Winterova
authors.forename: Martina
authors.initials: M
authors.lastname: Lengerova
authors.forename: Shira
authors.initials: S
authors.lastname: Timilsina
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology; D001419:Bacteria / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D011446:Prospective Studies; D012189:Retrospective Studies; D047071:beta-Glucans / Q000097:blood* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D047071:beta-Glucans