title: Bone resorption markers and dual-energy x-ray absorptiometry in dogs with avascular necrosis, degenerative joint disease, and trauma of the coxofemoral joint.
abstract: OBJECTIVE
  To compare the ability of N-terminal telopeptide (NTx) assays and dual-energy x-ray absorptiometry (DEXA) to detect bone resorption in dogs with nonneoplastic bone lysis and evaluate the correlation between these diagnostic tools.
  
  
  METHODS
  Prospective, cross-sectional clinical study.
  
  
  METHODS
  Dogs (n = 35; 39 femoral heads) that had femoral head and neck ostectomy and 6 cadaver specimens from healthy immature small dogs.
  
  
  METHODS
  Small dogs with avascular necrosis (n = 12), a reference group of small dogs (7), large dogs with degenerative joint disease (DJD; 10), and large dogs with trauma (10) were studied in addition to 6 femoral heads harvested from 6 small immature and healthy dogs euthanatized for reasons unrelated to this study. Densitometric measurements of femoral heads, urine NTx excretion, and serum NTx concentration were compared between groups.
  
  
  RESULTS
  Avascular necrosis resulted in a decrease in bone mineral density (BMD) (0.18 ± 0.01 g/cm(2;) P < .01) of the femoral head and elevation of serum NTx (159.3 ± 59.4 nM; P = .03) compared to small dog controls (0.28 ± 0.02 g/cm(2) ; 18.7 ± 1.83 nM, respectively), but did not seem to affect urine NTx. DJD in large dogs did not seem to affect any of the densitometric parameters evaluated. BMD (P = .03) and serum NTx (P = .04) were lower in small compared to large dogs. Serum NTx and densitometric measurements correlate inversely with each other (P = .001) but neither test correlated with urine NTx (P = .8-.9).
  
  
  CONCLUSIONS
  Serum NTx levels vary with dog size but seem to correlate better with BMD better than urine NTx excretion in dogs with nonneoplastic bone resorption.
authors.affiliation: VCA Veterinary Specialty Center, Indianapolis, IN, USA.
authors.forename: David
authors.initials: D
authors.lastname: Youkhanna
authors.forename: Dominique J
authors.initials: DJ
authors.lastname: Griffon
authors.forename: Page
authors.initials: P
authors.lastname: Fredericks
authors.forename: David
authors.initials: D
authors.lastname: Schaeffer
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Fan
authors.forename: Iwona M
authors.initials: IM
authors.lastname: Jasiuk
mesh_terms: D015502:Absorptiometry, Photon / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001862:Bone Resorption / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D006621:Hip Joint / Q000473:pathology*; D007592:Joint Diseases / Q000097:blood / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male
chemical_list: D015415:Biomarkers