title: Synthesis of imidazo[2,1-b]thiazoles linked to an unprotected carbohydrate moiety.
abstract: Two series of imidazo[2,1-b]thiazoles substituted on C-3 or C-5 with an unprotected carbohydrate moiety were synthesized. Different protective groups for position 3 of the carbohydrate moiety were tested (acetyl, tert-butyldimethylsilyl (TBDMS), and p-methoxybenzyl (PMB)) and the latter turn out to be the best strategy to obtain the desired products. Full deprotection of the carbohydrate was performed successfully in only one step.
authors.affiliation: CIHIDECAR-CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: José Sebastián
authors.initials: JS
authors.lastname: Barradas
authors.forename: María Inés
authors.initials: MI
authors.lastname: Errea
authors.forename: Norma Beatriz
authors.initials: NB
authors.lastname: D'Accorso
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D007093:Imidazoles; D013844:Thiazoles