title: Bringing next-generation therapeutics to the clinic through synthetic biology.
abstract: Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.
authors.affiliation: Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
authors.forename: Lukasz J
authors.initials: LJ
authors.lastname: Bugaj
authors.forename: David V
authors.initials: DV
authors.lastname: Schaffer
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D053263:Gene Regulatory Networks / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D013812:Therapeutics / Q000379:methods*