title: Biochemistry of bacterial multidrug efflux pumps.
abstract: Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.
authors.affiliation: QC Laboratory, Post Harvest Technology Department, Central Institute of Fisheries Education (CIFE), Versova, Mumbai 400061 India.
authors.forename: Sanath
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Biology Department, Eastern New Mexico University, Portales New Mexico, 88130, USA.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Varela
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017920:Antiporters / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000473:pathology; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D006801:Humans; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D017920:Antiporters; D037521:Virulence Factors