title: Immunomodulatory effects of alcbholic and hydroalcoholic extracts of Moringa olifera Lam leaves.
abstract: Effects of 50, 100 and 200 mg/kg body weight of the alcoholic and hydro-alcoholic extract of leaves of M. olifera were studied on various immune paradigms like delayed type hypersensitivity reaction using SRBC as an antigen, determination of antibody titer, neutrophil adhesion test as an indicator for neutrophil index, total leucocyte count in cyclophosphamide induced immunosuppressed animals and carbon clearance assay as a measure of phagocytic activity. Hydro-alcoholic extract of M. olifera substantially enhanced cellular immune response, humoral immune response, neutrophil index and phagoctic activity in doses of 100 and 200 mg/kg body weight. The ethanolic extract (200 mg/kg body weight) was efficient in improving immune response. The results suggest that M. olifera has a significant role to play as an immune stimulator.
authors.affiliation: Department of Pharmacology and Toxicology, Nalanda College of Pharmacy, Cherlapally, Nalgonda-508001, India. otiliabanji@gmail.com
authors.forename: Otilia J F
authors.initials: OJ
authors.lastname: Banji
authors.forename: David
authors.initials: D
authors.lastname: Banji
authors.forename: R
authors.initials: R
authors.lastname: Kavitha
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000438:Alcohols / Q000737:chemistry*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D029587:Moringa / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000276:Adjuvants, Immunologic; D000438:Alcohols; D010936:Plant Extracts