title: Mathematical models for insulin secretion in pancreatic β-cells.
abstract: Insulin secretion is one of the most characteristic features of β-cell physiology. As it plays a central role in glucose regulation, a number of experimental and theoretical studies have been performed since the discovery of the pancreatic β-cell. This review article aims to give an overview of the mathematical approaches to insulin secretion. Beginning with the bursting electrical activity in pancreatic β-cells, we describe effects of the gap-junction coupling between β-cells on the dynamics of insulin secretion. Then, implications of paracrine interactions among such islet cells as α-, β-, and δ-cells are discussed. Finally, we present mathematical models which incorporate effects of glycolysis and mitochondrial glucose metabolism on the control of insulin secretion.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, South Korea.
authors.forename: Kyungreem
authors.initials: K
authors.lastname: Han
authors.forename: Hyuk
authors.initials: H
authors.lastname: Kang
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
authors.forename: Mooyoung
authors.initials: M
authors.lastname: Choi
mesh_terms: D000818:Animals; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D007328:Insulin