title: Cycloheximide impairs and enhances memory depending on dose and footshock intensity.
abstract: This experiment examined the effects on memory of interactions of cycloheximide dose and training foot shock intensity. Mice received injections of cycloheximide (120 mg/kg, s.c.) or saline 30 min prior to inhibitory avoidance training with shock intensities of 100, 150, 250 or 300 μA (1 s duration). Memory was tested 48 h later. The saline control mice showed increasing memory latencies as a function of shock intensity. The ability of cycloheximide to impair memory increased as the training shock intensity increased. In a second experiment, mice were trained with a 200 μA (1 s duration) shock and received injections of saline or cycloheximide at one of several doses (30, 60 or 120 mg/kg). Under these training conditions, cycloheximide enhanced memory in an inverted-U dose-response manner. These findings are consistent with prior findings suggesting that protein synthesis inhibitors act on memory by altering modulators of memory formation as a secondary consequence of the inhibition of protein synthesis rather than by interfering with training-initiated synthesis of proteins required for memory formation.
authors.affiliation: Department of Biology, Life Sciences Complex, Syracuse University, Syracuse, NY 13244, USA. pegold@syr.edu
authors.forename: Paul E
authors.initials: PE
authors.lastname: Gold
authors.forename: Sean M
authors.initials: SM
authors.lastname: Wrenn
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001703:Biophysics; D003513:Cycloheximide / Q000627:therapeutic use / Q000633:toxicity; D004195:Disease Models, Animal; D004597:Electroshock / Q000009:adverse effects*; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology*; D051379:Mice; D008813:Mice, Inbred ICR; D011500:Protein Synthesis Inhibitors / Q000627:therapeutic use* / Q000633:toxicity*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide