title: Decrease of CD44-positive cells correlates with tumor response to chemotherapy in patients with gastrointestinal cancer.
abstract: OBJECTIVE
  CD44 is a multistructural and multifunctional cell surface molecule which is involved in cell proliferation, differentiation, migration and angiogenesis. Here we investigated the potential role of CD44 in patients with metastasized pancreatic ductal adenocarcinoma, colorectal and stomach cancer, which were treated with different combinations of palliative chemotherapy.
  
  
  METHODS
  CD44 expression was measured by flow cytometry in patients' (n=15) blood samples and the findings were correlated with CA19-9 expression and with computed tomography results.
  
  
  RESULTS
  We found a significant correlation (p<0.05) between the CD44 decrease and the tumor response according to the tumor marker elevation/ response evaluation criteria in solid tumors.
  
  
  CONCLUSIONS
  We were able to monitor changes of CD44 expression after chemotherapy and detected a correlation between the CD44 decrease and the patients' response to treatment. Our findings show that CD44 detection helps to monitor chemotherapy response in patients with gastrointestinal cancer.
authors.affiliation: Department of Internal Medicine I, Medical University Hospital, Otfried Mueller Str. 10, 72076 Tuebingen, Germany.
authors.forename: Vindhya
authors.initials: V
authors.lastname: Palagani
authors.forename: Mona
authors.initials: M
authors.lastname: El Khatib
authors.forename: Till
authors.initials: T
authors.lastname: Krech
authors.forename: Michael P
authors.initials: MP
authors.lastname: Manns
authors.forename: Nisar P
authors.initials: NP
authors.lastname: Malek
authors.forename: Ruben R
authors.initials: RR
authors.lastname: Plentz
mesh_terms: D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood; D045744:Cell Line, Tumor; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D018395:CA-19-9 Antigen; C497483:CD44 protein, human; D018960:Hyaluronan Receptors