title: Prognostic value of indeterminate IFN-γ release assay results in HIV-1 infection.
abstract: In this prospective, longitudinal study on 948 HIV-1-infected patients, subjects with an indeterminate IFN-γ (gamma interferon) release assay (IGRA) result at baseline were at significantly higher risk of developing AIDS-defining manifestations other than tuberculosis (TB) irrespective of CD4(+) T cell count. Thus, in HIV-1-infected patients with advanced quantitative CD4(+) T cell depletion, an indeterminate IGRA might indicate an additional loss of global T cell function, warranting detailed clinical evaluation and careful follow-up.
authors.affiliation: Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria. maximilian.aichelburg@meduniwien.ac.at
authors.forename: Maximilian C
authors.initials: MC
authors.lastname: Aichelburg
authors.forename: Julia
authors.initials: J
authors.lastname: Tittes
authors.forename: Florian
authors.initials: F
authors.lastname: Breitenecker
authors.forename: Thomas
authors.initials: T
authors.lastname: Reiberger
authors.forename: Norbert
authors.initials: N
authors.lastname: Kohrgruber
authors.forename: Armin
authors.initials: A
authors.lastname: Rieger
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019247:HIV Wasting Syndrome / Q000175:diagnosis*; D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies