title: Dietary Yucca schidigera supplementation reduces arsenic-induced oxidative stress in Swiss albino mice.
abstract: The aim of this study was to clarify the effects of dietary supplementation with Yucca schidigera (Ys) on lipid peroxidation (LPO), antioxidant activity, some biochemical parameters and histopathological changes in arsenic-exposed mice. Forty Swiss albino male mice were divided into five equal groups. Group I (control group) was given normal diet and tap water for 28 days. Group II (arsenic group) was given normal diet and 100 mg/L arsenic along with drinking water for 28 days. Groups III-V were given three different doses of Ys (50, 100 and 200 mg/kg) in supplemented diet and arsenic (100 mg/L) along with drinking water throughout the entire period of 28 days. The arsenic significantly increased serum biochemical parameters and malondialdehyde levels in blood and tissue. However, arsenic significantly decreased tissue glutathione concentration, erythrocyte superoxide dismutase and catalase activities. In contrast, dietary supplementation of Ys, in a dose-dependent manner, resulted in reversal of arsenic-induced oxidative stress, LPO and activities of antioxidant enzymes. Moreover, Ys also exhibited protective action against the arsenic-induced focal gliosis and hyperemi in brain, necrosis and degeneration in liver, degeneration and dilatation in Bowman's capsule of kidney and hyaline degeneration in heart tissue of mice. Consequently, our results demonstrate that Ys especially high-dose supplementation in diet decreases arsenic-induced oxidative stress and enhances the antioxidant defence mechanism and regenerate of tissues in Swiss albino mice.
authors.affiliation: 1Department of Pharmacology and Toxicology, University of Afyon Kocatepe, Afyonkarahisar, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Ince
authors.forename: Ismail
authors.initials: I
authors.lastname: Kucukkurt
authors.forename: Ruhi
authors.initials: R
authors.lastname: Turkmen
authors.forename: Hasan Huseyin
authors.initials: HH
authors.lastname: Demirel
authors.forename: Emine
authors.initials: E
authors.lastname: Sever
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D005978:Glutathione / Q000032:analysis / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009928:Organ Specificity; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000097:blood; D028321:Plant Preparations / Q000494:pharmacology*; D027623:Yucca / Q000737:chemistry*
chemical_list: D028321:Plant Preparations; D010088:Oxidoreductases; D005978:Glutathione; D001151:Arsenic