title: Diversin, from Ferula diversivittata protects human lymphocytes against oxidative stress induced by H₂O₂.
abstract: In this study, the antigenotoxic effects of diversin, a prenylated coumarin obtained from Ferula diversivittata roots were evaluated using comet assay. Isolated lymphocytes from healthy volunteers' blood samples were incubated with diversin (10, 25, 50, 100, 200 and 400 µM) alone, or in the presence of H2O2 (25 µM). DNA break was measured based on the %tail DNA and compared with different concentrations of curcumin (10, 25 and 50 µM) as the positive control. It was shown that all concentrations of diversin significantly reduce DNA damage caused by H2O2.
authors.affiliation: Department of Pharmacology and Toxicology School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Zarei
authors.forename: Ramin
authors.initials: R
authors.lastname: Rezaee
authors.forename: Effat
authors.initials: E
authors.lastname: Behravan
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Soltani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mosaffa
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
authors.forename: Javad
authors.initials: J
authors.lastname: Behravan
mesh_terms: D003374:Coumarins / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008214:Lymphocytes / Q000502:physiology*; D039821:Monoterpenes / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D003374:Coumarins; D039821:Monoterpenes; C551724:diversin; D006861:Hydrogen Peroxide