title: The bad, the good, and the ugly about oxidative stress.
abstract: Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available. Therefore, it is urgently needed to understand the molecular basis of these disorders. Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases. Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise. This mechanism might provide the basis for therapeutic design strategies. Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the "oxidative stress model" in neurodegeneration and cancer.
authors.affiliation: School of Medicine, Medical Research Institute, Neuroscience Research Group, University of Antioquia (UdeA), SIU, Calle 62 # 52-59, Building 1, Room 412, Medellin 1226, Colombia. marlene.jimenez@neurociencias.udea.edu.co
authors.forename: Marlene
authors.initials: M
authors.lastname: Jimenez-Del-Rio
authors.forename: Carlos
authors.initials: C
authors.lastname: Velez-Pardo
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D016923:Cell Death; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D010300:Parkinson Disease / Q000473:pathology
chemical_list: D010100:Oxygen