title: New lung cancer susceptibility locus identified: significance and implications for other genome-wide association studies.
abstract: Genome-wide association studies have identified more than 150 loci that influence the risk of cancer. In this issue of Cancer Discovery, Shi and colleagues report that a variant in RAD52 is a risk factor for squamous cell lung carcinoma. This work is important not only for its potential implications on control of this dreaded malignancy but also for its methodologic contributions that can advance the field of molecular-genetic epidemiology.
authors.affiliation: Department of Cancer Epidemiology, Biostatics Core, Moffitt Cancer Center, Tampa, Florida 33612, USA. thomas.sellers@moffitt.org
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Sellers
authors.forename: Y Ann
authors.initials: YA
authors.lastname: Chen
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D051721:Rad52 DNA Repair and Recombination Protein / Q000235:genetics*
chemical_list: C497194:RAD52 protein, human; D051721:Rad52 DNA Repair and Recombination Protein