title: What a difference a phosphate makes: life or death decided by a single amino acid in MDM2.
abstract: In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA.
authors.forename: Yao-Cheng
authors.initials: YC
authors.lastname: Li
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA. Electronic address: wahl@salk.edu.
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Wahl