title: Comprehensive investigation of genetic variation in the 8q24  region and multiple myeloma risk in the IMMEnSE consortium.
abstract: Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.
authors.affiliation: Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany.
authors.forename: Daniele
authors.initials: D
authors.lastname: Campa
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martino
authors.forename: Juan
authors.initials: J
authors.lastname: Sainz
authors.forename: Gabriele
authors.initials: G
authors.lastname: Buda
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jamroziak
authors.forename: Niels
authors.initials: N
authors.lastname: Weinhold
authors.forename: Rui Manuel
authors.initials: RM
authors.lastname: Vieira Reis
authors.forename: Ramón
authors.initials: R
authors.lastname: García-Sanz
authors.forename: Manuel
authors.initials: M
authors.lastname: Jurado
authors.forename: Rafael
authors.initials: R
authors.lastname: Ríos
authors.forename: Zofia
authors.initials: Z
authors.lastname: Szemraj-Rogucka
authors.forename: Herlander
authors.initials: H
authors.lastname: Marques
authors.forename: Fabienne
authors.initials: F
authors.lastname: Lesueur
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj
authors.forename: Enrico
authors.initials: E
authors.lastname: Orciuolo
authors.forename: Federica
authors.initials: F
authors.lastname: Gemignani
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Rossi
authors.forename: Charles
authors.initials: C
authors.lastname: Dumontet
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.forename: Stefano
authors.initials: S
authors.lastname: Landi
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
mesh_terms: D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide