title: Graphite nanoplatelets and Caenorhabditis elegans: insights from an in vivo model.
abstract: We evaluated the toxicity of graphite nanoplatelets (GNPs) in the model organism Caenorhabditis elegans. The GNPs resulted nontoxic by measuring longevity as well as reproductive capability end points. An imaging technique based on Fourier transform infrared spectroscopy (FT-IR) mapping was also developed to analyze the GNPs spatial distribution inside the nematodes. Conflicting reports on the in vitro antimicrobial properties of graphene-based nanomaterials prompted us to challenge the host-pathogen system C. elegans-Pseudomonas aeruginosa to assess these findings through an in vivo model.
authors.affiliation: Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Zanni
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Bellis
authors.forename: Maria P
authors.initials: MP
authors.lastname: Bracciale
authors.forename: Alessandra
authors.initials: A
authors.lastname: Broggi
authors.forename: Maria L
authors.initials: ML
authors.lastname: Santarelli
authors.forename: Maria S
authors.initials: MS
authors.lastname: Sarto
authors.forename: Claudio
authors.initials: C
authors.lastname: Palleschi
authors.forename: Daniela
authors.initials: D
authors.lastname: Uccelletti
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006108:Graphite / Q000633:toxicity*; D053758:Nanoparticles / Q000633:toxicity*; D015996:Survival Rate
chemical_list: D006108:Graphite