title: Prostaglandin F2α: a bone remodeling mediator.
abstract: Prostaglandin F2α (PGF2α) plays multiple roles on bone metabolism by regulating a wide range of signaling pathways. PGF2α, via activation of PKC, stimulates Na-dependent inorganic phosphate (Pi) transport system in osteoblasts; up-regulates interleukin (IL)-6 synthesis; increases vascular endothelial growth factor (VEGF). In addition, PGF2α acts as a strong mitogenic and survival agent on osteoblasts, and these effects are, at least in part, mediated by the binding of fibroblast growth factor-2 (FGF-2) to the specific receptor FGFR1. The understanding of PGF2α intracellular network, albeit complex to clarify, provides molecular bases useful to identify the players of osteoblast proliferation, apoptosis, and the associated angiogenic processes. Indeed, the molecular mechanism that underline PGF2α-regulated bone metabolism may be a promising platform for the development of novel targeted therapies in the treatment of bone disorders and disease.
authors.affiliation: School of Biosciences and Biotechnology, University of Camerino, Camerino (MC), Italy.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Agas
authors.forename: Luigi
authors.initials: L
authors.lastname: Marchetti
authors.forename: Marja M
authors.initials: MM
authors.lastname: Hurley
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Sabbieti
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D002113:Calcification, Physiologic / Q000502:physiology; D015237:Dinoprost / Q000235:genetics / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D010006:Osteoblasts / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D015850:Interleukin-6; D017468:Receptors, Fibroblast Growth Factor; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D015237:Dinoprost