title: An improved microwave assisted one-pot synthesis, and biological investigations of some novel aryldiazenyl chromeno fused pyrrolidines.
abstract: An improved microwave assisted one-pot method for the synthesis of twelve new aryldiazenylchromeno [4,3-b] pyrrolidines via intramolecular azomethine ylide cycloaddition route is described. The method is efficient and advantageous over conventional and solvent-free thermal methods. The stereochemistry of the compounds was confirmed on the basis of various NMR experiments, and finally by single crystal X-ray diffraction data. N-Methyl or ethyl pyrrolidine based heterocycles gave good biological activities.
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Dist. Anand, Gujarat, India. njpchemdeptspu@yahoo.co.in
authors.forename: Narsidas J
authors.initials: NJ
authors.lastname: Parmar
authors.forename: Bhavesh R
authors.initials: BR
authors.lastname: Pansuriya
authors.forename: Hitesh A
authors.initials: HA
authors.lastname: Barad
authors.forename: Rajni
authors.initials: R
authors.lastname: Kant
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Gupta
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000254:growth & development; D001391:Azo Compounds / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D000995:Antitubercular Agents; D001391:Azo Compounds; D001578:Benzopyrans; D011759:Pyrrolidines; D013882:Thiosemicarbazones; C512188:azomethine