title: Nanoporous peptide particles for encapsulating and releasing neurotrophic factors in an animal model of neurodegeneration.
abstract: Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.
authors.affiliation: Bionics Institute, East Melbourne, Victoria 3002, Australia.
authors.forename: Justin
authors.initials: J
authors.lastname: Tan
authors.forename: Yajun
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Yip
authors.forename: Fergal
authors.initials: F
authors.lastname: Glynn
authors.forename: Robert K
authors.initials: RK
authors.lastname: Shepherd
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003051:Cochlea / Q000378:metabolism; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D016062:Porosity
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004337:Drug Carriers; D010455:Peptides; C097188:polyglutamine