title: Plasma hemopexin as a potential regulator of vascular responsiveness to angiotensin II.
abstract: This brief review focuses on the functional activities of plasma hemopexin recently recognized by several authors. In particular, the protease-like activity of hemopexin in vitro is linked with downregulation of the vascular angiotensin II receptor in vivo, leading to vascular expansion. Also a potential mechanism of inhibition of hemopexin activity by extracellular adenosine triphosphate is considered.
authors.affiliation: Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, The Netherlands. w.w.bakker@umcg.nl
authors.forename: Winston W
authors.initials: WW
authors.lastname: Bakker
authors.forename: Floor
authors.initials: F
authors.lastname: Spaans
authors.forename: Loubna
authors.initials: L
authors.lastname: el Bakkali
authors.forename: Theo
authors.initials: T
authors.lastname: Borghuis
authors.forename: Harry
authors.initials: H
authors.lastname: van Goor
authors.forename: Evert
authors.initials: E
authors.lastname: van Dijk
authors.forename: Joshua
authors.initials: J
authors.lastname: Buijnink
authors.forename: Marijke M
authors.initials: MM
authors.lastname: Faas
mesh_terms: D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D005260:Female; D006466:Hemopexin / Q000502:physiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011485:Protein Binding / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D000804:Angiotensin II; D006466:Hemopexin