title: A new triterpenoid saponin from Sanguisorba officinalis.
abstract: A new 19-oxo-18,19-seco-ursane-type triterpenoid saponin, named sanguisoside A (1), along with nine known triterpenoid saponins (2-10), was isolated from the roots of Sanguisorba officinalis. Their structures were determined on the basis of spectroscopic analysis and chemical method. Compounds 2 and 3 showed cytotoxic activity against SGC-7901, SMMC-7721, A549, and DU145 cell lines.
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China.
authors.forename: Pei-Yuan
authors.initials: PY
authors.lastname: Zhang
authors.forename: San-Hai
authors.initials: SH
authors.lastname: Qin
authors.forename: Huan-Xin
authors.initials: HX
authors.lastname: Zhao
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Wang
authors.forename: Huan-Jie
authors.initials: HJ
authors.lastname: Guo
authors.forename: Hong
authors.initials: H
authors.lastname: Bai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D031993:Sanguisorba / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C574117:sanguisoside A