title: Immunodeficiency-associated vaccine-derived poliovirus type 3 in infant, South Africa, 2011.
abstract: Patients with primary immunodeficiency are prone to persistently excrete Sabin-like virus after administration of live-attenuated oral polio vaccine and have an increased risk for vaccine-derived paralytic polio. We report a case of type 3 immunodeficiency-associated vaccine-derived poliovirus in a child in South Africa who was born with X-linked immunodeficiency syndrome.
authors.affiliation: National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa. nicksyg@nicd.ac.za
authors.forename: Nicksy
authors.initials: N
authors.lastname: Gumede
authors.forename: Vongani
authors.initials: V
authors.lastname: Muthambi
authors.forename: Barry D
authors.initials: BD
authors.lastname: Schoub
mesh_terms: D036022:Capsid Proteins / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D017955:Poliovirus / Q000235:genetics*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*; D017422:Sequence Analysis, DNA; D013019:South Africa; D014613:Vaccines, Attenuated / Q000009:adverse effects; D053632:X-Linked Combined Immunodeficiency Diseases / Q000150:complications / Q000175:diagnosis*
chemical_list: D036022:Capsid Proteins; D011055:Poliovirus Vaccine, Oral; C442540:VP1 protein, Poliovirus; D014613:Vaccines, Attenuated