title: A rare case of hyperammonemia complication of high-protein parenteral nutrition.
abstract: Hyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late-onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28-year-old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.
authors.affiliation: Wayne State University, Ste-908, John R Rd, Detroit, MI 48201, USA. unnikrishnanpk@yahoo.com
authors.forename: Unnikrishnan
authors.initials: U
authors.lastname: Pillai
authors.forename: Roopkiranjot
authors.initials: R
authors.lastname: Kahlon
authors.forename: James
authors.initials: J
authors.lastname: Sondheimer
authors.forename: Pravit
authors.initials: P
authors.lastname: Cadnapaphorncai
authors.forename: Zeenat
authors.initials: Z
authors.lastname: Bhat
mesh_terms: D000328:Adult; D000641:Ammonia / Q000097:blood*; D001929:Brain Edema / Q000209:etiology*; D004044:Dietary Proteins / Q000097:blood*; D017809:Fatal Outcome; D006801:Humans; D022124:Hyperammonemia / Q000097:blood / Q000209:etiology*; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D006435:Renal Dialysis; D051437:Renal Insufficiency; D056806:Urea Cycle Disorders, Inborn / Q000150:complications* / Q000201:enzymology
chemical_list: D004044:Dietary Proteins; D000641:Ammonia