title: No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds.
abstract: Decreased blood-brain barrier P-glycoprotein (Pgp) function has been shown in Alzheimer's disease (AD) patients using positron emission tomography (PET) with the radiotracer (R)-[(11)C]verapamil. Decreased Pgp function has also been hypothesized to promote cerebral amyloid angiopathy (CAA) development. Here, we used PET and (R)-[(11)C]verapamil to assess Pgp function in eighteen AD patients, of which six had microbleeds (MBs), presumably reflecting underlying CAA. No differences were found in binding potential and nonspecific volume of distribution of (R)-[(11)C]verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs.
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. d.vanassema@vumc.nl
authors.forename: Daniëlle M E
authors.initials: DM
authors.lastname: van Assema
authors.forename: Jeroen D C
authors.initials: JD
authors.lastname: Goos
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: Mark
authors.initials: M
authors.lastname: Lubberink
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Albert D
authors.initials: AD
authors.lastname: Windhorst
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011485:Protein Binding; D014700:Verapamil / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002250:Carbon Radioisotopes; D014700:Verapamil