title: A Skew-t space-varying regression model for the spectral analysis of resting state brain activity.
abstract: It is known that in many neurological disorders such as Down syndrome, main brain rhythms shift their frequencies slightly, and characterizing the spatial distribution of these shifts is of interest. This article reports on the development of a Skew-t mixed model for the spatial analysis of resting state brain activity in healthy controls and individuals with Down syndrome. Time series of oscillatory brain activity are recorded using magnetoencephalography, and spectral summaries are examined at multiple sensor locations across the scalp. We focus on the mean frequency of the power spectral density, and use space-varying regression to examine associations with age, gender and Down syndrome across several scalp regions. Spatial smoothing priors are incorporated based on a multivariate Markov random field, and the markedly non-Gaussian nature of the spectral response variable is accommodated by the use of a Skew-t distribution. A range of models representing different assumptions on the association structure and response distribution are examined, and we conduct model selection using the deviance information criterion. (1) Our analysis suggests region-specific differences between healthy controls and individuals with Down syndrome, particularly in the left and right temporal regions, and produces smoothed maps indicating the scalp topography of the estimated differences.
authors.affiliation: Department of Mathematics and Statistics, University of Victoria, Victoria, Canada.
authors.forename: Salimah
authors.initials: S
authors.lastname: Ismail
authors.forename: Wenqi
authors.initials: W
authors.lastname: Sun
authors.forename: Farouk S
authors.initials: FS
authors.lastname: Nathoo
authors.forename: Arif
authors.initials: A
authors.lastname: Babul
authors.forename: Alexader
authors.initials: A
authors.lastname: Moiseev
authors.forename: Mirza Faisal
authors.initials: MF
authors.lastname: Beg
authors.forename: Naznin
authors.initials: N
authors.lastname: Virji-Babul
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D056808:Biostatistics; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D016022:Case-Control Studies; D004314:Down Syndrome / Q000503:physiopathology; D059907:Functional Neuroimaging / Q000706:statistics & numerical data*; D006801:Humans; D015225:Magnetoencephalography / Q000706:statistics & numerical data*; D008390:Markov Chains; D008959:Models, Neurological; D009010:Monte Carlo Method; D016011:Normal Distribution; D012044:Regression Analysis