title: [History of systemic sclerosis].
abstract: Systemic sclerosis (Scleroderma) is a generalized disease of the connective tissue, whose etiology is unknown, and which produces fibrosis and degenerative changes in the skin (scleroderma), synovial membrane, arterial vessels, skeletal muscle, and certain internal organs, especially the gastrointestinal tract, lung, heart, and kidney. Patients with cutaneous alterations, which could have been scleroderma cases, have been described since the most distant ancient times, and since the end of XIX century its recognition has been accurate. In the past century more precise diagnoses and treatments were possible because of the knowledge of its pathogenesis and its classification into clinic-serologic subgroups. We intend to recall the names and contributions of the doctors who collaborated with the advances throughout history.
authors.affiliation: Servicio de Reumatología, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Hugo
authors.initials: H
authors.lastname: Armando Laborde
authors.forename: Pablo
authors.initials: P
authors.lastname: Young
mesh_terms: D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D012595:Scleroderma, Systemic / Q000266:history*