title: Drugging Wnt signalling in cancer.
abstract: Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided.
authors.affiliation: Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA. ppolakis@gene.com
authors.forename: Paul
authors.initials: P
authors.lastname: Polakis
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D060449:Wnt Signaling Pathway