title: Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia.
abstract: Oral leukoplakia is a pre-malignant lesion of the oral mucosa. The aim of this study is to compare the curative effects of photodynamic therapy and cryotherapy in the treatment of oral leukoplakia. The first group, treated by photodynamic therapy (δ-aminolevulinic acid (ALA), 630-635 nm wavelength), consisted of 48 patients suffering from leukoplakia. The second group consisted of 37 patients treated using cryotherapy. Analyses and comparisons of the complete responses, recurrences, numbers of procedures and adverse effects after both PDT and cryotherapy were obtained. In the first group, a complete response was obtained in 35 patients (72.9%), with thirteen recurrences observed (27.1%) over a six-month period. In the second group, a complete response was obtained in 33 patients (89.2%), and recurrence was observed in nine patients (24.3%). Photodynamic therapy and cryotherapy appear to be comparative methods of treatment that may both serve as alternatives for the traditional surgical treatment of oral leukoplakia. The advantages of PDT are connected with minimally invasive and localized character of the treatment and with not damage of collagenous tissue structures, therefore normal cells will repopulate these arrangements. PDT is more convenient for patients, less painful, and more esthetic.
authors.affiliation: Department and Clinic of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia, Batorego 15 St, 41-902 Bytom, Poland. akawczyk@gmail.com
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kawczyk-Krupka
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Waśkowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Raczkowska-Siostrzonek
authors.forename: Anna
authors.initials: A
authors.lastname: Kościarz-Grzesiok
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kwiatek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Straszak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Latos
authors.forename: Rafał
authors.initials: R
authors.lastname: Koszowski
authors.forename: Aleksander
authors.initials: A
authors.lastname: Sieroń
mesh_terms: D000328:Adult; D000368:Aged; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D003452:Cryosurgery / Q000379:methods*; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid