title: Improved synthesis of 5-substituted 1H-tetrazoles via the [3+2] cycloaddition of nitriles and sodium azide catalyzed by silica sulfuric acid.
abstract: A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.|Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China.
authors.forename: Zhenting
authors.initials: Z
authors.lastname: Du
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Changmei
authors.initials: C
authors.lastname: Si
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Youqiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction / Q000379:methods*; D009570:Nitriles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D019810:Sodium Azide / Q000737:chemistry*; D013464:Sulfuric Acids / Q000737:chemistry*; D013777:Tetrazoles / Q000138:chemical synthesis*
chemical_list: D009570:Nitriles; D013464:Sulfuric Acids; D013777:Tetrazoles; D012822:Silicon Dioxide; D019810:Sodium Azide