title: Catalytic, enantio- and diastereoselective synthesis of γ-butyrolactones incorporating quaternary stereocentres.
abstract: A new, highly enantio- and diastereoselective catalytic asymmetric formal cycloaddition of aryl succinic anhydrides and aldehydes which generates paraconic acid (γ-butyrolactone) derivatives is reported.
authors.affiliation: School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity Biomedical Sciences Institute, University of Dublin, Trinity College, Dublin 2, Ireland.
authors.forename: Francesco
authors.initials: F
authors.lastname: Manoni
authors.forename: Claudio
authors.initials: C
authors.lastname: Cornaggia
authors.forename: James
authors.initials: J
authors.lastname: Murray
authors.forename: Sean
authors.initials: S
authors.lastname: Tallon
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Connon
mesh_terms: D015107:4-Butyrolactone / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D013237:Stereoisomerism; D013387:Succinic Anhydrides / Q000737:chemistry
chemical_list: D000447:Aldehydes; D013387:Succinic Anhydrides; D015107:4-Butyrolactone