title: Validity and variability of the 5-repetition sit-to-stand test in patients with multiple sclerosis.
abstract: OBJECTIVE
  To investigate; (i) the relationship between the 5STS-test and lower extremity muscle strength and balance, and (ii) the variability of the 5STS-test in multiple sclerosis (MS) patients.
  
  
  METHODS
  22 MS patients were divided into two groups (Group A and Group B) who completed one 5STS familiarization test session and two testing sessions. In Group A, session 1 also included assessment of lower extremity muscle strength. Session 2 and 3 involved completion of two 5STS-tests and assessment of balance. In Group B, session 2 and 3 involved completion of two rounds of two 5STS-tests separated by a 30 min break.
  
  
  RESULTS
  Significant correlations were found between the 5STS-test and isometric and isokinetic knee flexor and extensor muscle strength of the most affected leg (R = -0.60 to -0.77), and between the 5STS-test and balance performance (R = 0.69). Intra-assessor day-to-day variability, intra-assessor test-retest variability and intra-assessor variability within test were 25.5, 22.3, and 23.1%, respectively. Inter-assessor variability within test and inter-assessor variability were 23.4 and 5.9%, respectively.
  
  
  CONCLUSIONS
  The 5STS-test is related to lower extremity muscle strength and to balance performance in MS patients. For interventional purposes, a change of >25% can be regarded as a real change.
authors.affiliation: Department of Public Health, Section of Sport Science, Aarhus University, Denmark. amj@sport.au.dk
authors.forename: Andreas Buch
authors.initials: AB
authors.lastname: Møller
authors.forename: Bo Martin
authors.initials: BM
authors.lastname: Bibby
authors.forename: Anders Guldhammer
authors.initials: AG
authors.lastname: Skjerbæk
authors.forename: Ellen
authors.initials: E
authors.lastname: Jensen
authors.forename: Henrik
authors.initials: H
authors.lastname: Sørensen
authors.forename: Egon
authors.initials: E
authors.lastname: Stenager
authors.forename: Ulrik
authors.initials: U
authors.lastname: Dalgas
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003718:Denmark; D004185:Disability Evaluation; D005080:Exercise Test / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D007866:Leg / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000534:rehabilitation*; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000503:physiopathology*; D004856:Postural Balance; D012372:ROC Curve; D015203:Reproducibility of Results