title: Replication of RYR3 gene polymorphism association with cIMT among HIV-infected whites.
abstract: To replicate the association of variants in RYR3 gene with common carotid intima-media thickness (cIMT), a surrogate marker of atherosclerosis, we genotyped single nucleotide polymorphisms (SNPs) rs2229116 and rs7177922 in a sub-population of 244 HIV-positive and HIV-negative men. SNP rs2229116 was associated with common cIMT in HIV infected white men after adjusting for age and use of stavudine (d4T). The association was more evident at younger ages and decreased among older individuals.
authors.affiliation: Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA. sshrestha@uab.edu
authors.forename: Sadeep
authors.initials: S
authors.lastname: Shrestha
authors.forename: Qi
authors.initials: Q
authors.lastname: Yan
authors.forename: Gregory
authors.initials: G
authors.lastname: Joseph
authors.forename: Donna K
authors.initials: DK
authors.lastname: Arnett
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Martinson
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Kingsley
mesh_terms: D000367:Age Factors; D050197:Atherosclerosis / Q000150:complications / Q000235:genetics*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D015658:HIV Infections / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel