title: Effect of dehydroepiandrosterone administration on recovery from mix-type exercise training-induced muscle damage.
abstract: This study aimed to determine the role of DHEA-S in coping against the exercise training mixing aerobic and resistance components. During 5-day successive exercise training, 16 young male participants (19.2 ± 1.2 years) received either a placebo (flour capsule) or DHEA (100 mg/day) in a double-blinded and placebo-controlled design. Oral DHEA supplementation significantly increased circulating DHEA-S by 2.5-fold, but a protracted drop (~35 %) was observed from Day 3 during training. In the Placebo group, only a minimal DHEA-S reduction (~17 %) was observed. Changes in testosterone followed a similar pattern as DHEA-S. Muscle soreness was elevated significantly on Day 2 for both groups to a similar extent. Lower muscle soreness was observed in the DHEA-supplemented group on Day 3 and Day 6. In the Placebo group, training increased circulating creatine kinase (CK) levels by approximately ninefold, while only a threefold increase was observed in the DHEA-supplemented group. This mix-type exercise training improved glucose tolerance in both groups, while lowering the insulin response to the glucose challenge, but no difference between treatments was observed. Our results suggest that DHEA-S may play a role in protecting skeletal muscle from exercise training-induced muscle damage.
authors.affiliation: Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA.
authors.forename: Yi-Hung
authors.initials: YH
authors.lastname: Liao
authors.forename: Kun-Fu
authors.initials: KF
authors.lastname: Liao
authors.forename: Chung-Lan
authors.initials: CL
authors.lastname: Kao
authors.forename: Chung-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Wei-Hsiang
authors.initials: WH
authors.lastname: Chang
authors.forename: John L
authors.initials: JL
authors.lastname: Ivy
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Bernard
authors.forename: Shin-Da
authors.initials: SD
authors.lastname: Lee
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Kuo
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D012090:Cumulative Trauma Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D003687:Dehydroepiandrosterone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries* / Q000503:physiopathology*; D020127:Recovery of Function / Q000187:drug effects*; D055070:Resistance Training; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D003687:Dehydroepiandrosterone