title: Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1.
abstract: Malaysian Gelam honey has anti-inflammatory and antibacterial properties, a high antioxidant capacity, and free radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells to sequentially release early pro- and anti-inflammatory cytokines and induces the synthesis of several related enzymes. The aim of this study was to investigate the effect of the intravenous injection of honey in rats with LPS-induced endotoxemia. The results showed that after 4h of treatment, honey reduced cytokine (tumor necrosis factor-α, interleukins 1β, and 10) and NO levels and increased heme oxygenase-1 levels. After 24h, a decrease in cytokines and NO and an increase in HO-1 were seen in all groups, whereas a reduction in HMGB1 occurred only in the honey-treated groups. These results support the further examination of honey as a natural compound for the treatment of a wide range of inflammatory diseases.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. zoobeadi@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kassim
authors.forename: Kamaruddin Mohd
authors.initials: KM
authors.lastname: Yusoff
authors.forename: Gracie
authors.initials: G
authors.lastname: Ong
authors.forename: Shamala
authors.initials: S
authors.lastname: Sekaran
authors.forename: Mohd Yasim Bin Md
authors.initials: MY
authors.lastname: Yusof
authors.forename: Marzida
authors.initials: M
authors.lastname: Mansor
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D056705:Apitherapy; D016207:Cytokines / Q000037:antagonists & inhibitors*; D019446:Endotoxemia / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006722:Honey; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides; D008296:Malaysia; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D024243:HMGB1 Protein; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009569:Nitric Oxide; D051547:Heme Oxygenase-1