title: Palladium-catalyzed amidation of aryl halides using 2-dialkylphosphino-2'-alkoxyl-1,1'-binaphthyl as ligands.
abstract: Palladium-catalyzed intermolecular C-N bond-forming reactions between aryl halides and amides are described using 2-dialkylphosphino-2'-alkoxyl-1,1'-binaphthyl, which is both bulky and electron-rich, as the ligand. A variety of amides, including aliphatic and aromatic primary amides, lactams, and carbamates, were viable substrates for the amidation, which exhibited good functional group compatibility. By tuning the substituents at the 2,2'-position of 1,1'-binaphthyl of the ligand, the palladium-catalyzed amidation of bulky aryl halides was realized and this coupling reaction was used to synthesize 2-amino-2'-methoxy-1,1'-binaphthyl in high yield.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Ma
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Xie
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Peng
authors.forename: Lina
authors.initials: L
authors.lastname: Ding
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000577:Amides / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D001713:Biphenyl Compounds; D006219:Halogens; D008024:Ligands; D010165:Palladium