title: Influence of trace elements in human tissue in low-energy photon brachytherapy dosimetry.
abstract: The aim of this paper is to determine the dosimetric impact of trace elements in human tissues for low-energy photon sources used in brachytherapy. Monte Carlo dose calculations were used to investigate the dosimetric effect of trace elements present in normal or cancerous human tissues. The effect of individual traces (atomic number Z = 11-30) was studied in soft tissue irradiated by low-energy brachytherapy sources. Three other tissue types (prostate, adipose and mammary gland) were also simulated with varying trace concentrations to quantify the contribution of each trace to the dose distribution. The dose differences between cancerous and healthy prostate tissues were calculated in single- and multi-source geometries. The presence of traces in a tissue produces a difference in the dose distribution that is dependent on Z and the concentration of the trace. Low-Z traces (Na) have a negligible effect (<0.3%) in all tissues, while higher Z (K) had a larger effect (>3%). There is a potentially significant difference in the dose distribution between cancerous and healthy prostate tissues (4%) and even larger if compared to the trace-free composition (15%) in both single- and multi-sourced geometries. Trace elements have a non-negligible (up to 8% in prostate D(90)) effect on the dose in tissues irradiated with low-energy photon sources. This study underlines the need for further investigation into accurate determination of the trace composition of tissues associated with low-energy brachytherapy. Alternatively, trace elements could be incorporated as a source of uncertainty in dose calculations.
authors.affiliation: Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands.
authors.forename: Shane A
authors.initials: SA
authors.lastname: White
authors.forename: Guillaume
authors.initials: G
authors.lastname: Landry
authors.forename: Francis
authors.initials: F
authors.lastname: van Gils
authors.forename: Frank
authors.initials: F
authors.lastname: Verhaegen
authors.forename: Brigitte
authors.initials: B
authors.lastname: Reniers
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D001918:Brachytherapy / Q000379:methods*; D001940:Breast / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009010:Monte Carlo Method; D017785:Photons / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D011874:Radiometry; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D014131:Trace Elements