title: [In vitro investigation of the antiviral activity of Ingavirin against human metapneumovirus].
abstract: The antiviral activity of Ingavirin against human metapneumovirus (HMPV) infection was investigated in vitro. The investigation used the human cell line ChangConjunctiva, permissive for HMPV, clone 1-5C4, and the HMPV strain isolated at the D. I. Ivanovsky Research Institute of Virology. The experimental studies suggest that when added at a concentration of 50 to 500 microg/ml to a nutrient medium 24 hours after HMPV infection, Ingavirin suppressed effectively virus replication by 2.2-3.3 logs, respectively. When used at a concentration of 500 microg/ml 24 hours before cell infection, Ingavirin protected cells from HMPV infection.
authors.forename: E I
authors.initials: EI
authors.lastname: Isaeva
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: I S
authors.initials: IS
authors.lastname: Kozulina
authors.forename: O V
authors.initials: OV
authors.lastname: Morozova
mesh_terms: D000047:Academies and Institutes; D000577:Amides / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000821:virology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D029121:Metapneumovirus / Q000187:drug effects* / Q000502:physiology; D018184:Paramyxoviridae Infections / Q000188:drug therapy / Q000821:virology; D016133:Polymerase Chain Reaction; D012426:Russia; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003470:Culture Media; D003998:Dicarboxylic Acids; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide