title: Formation and characterization of natural polysaccharide hollow nanocapsules via template layer-by-layer self-assembly.
abstract: With natural polysaccharides carrageenan (Car) and chitosan (Cs) as the polyanion and polycation, respectively, multilayer hollow nanocapsules have been fabricated via sequential layer-by-layer (LbL) electrostatic self-assembly from the sacrificed templates nanospheres (SiO(2)-NH(2)). The LbL assembly process with the polysaccharides on SiO(2)-NH(2) core was followed by ζ-potential and size analysis. The fabrication of (Car/Cs)(x) nanocapsules and the removing of the SiO(2)-NH(2) core templates were confirmed by TGA and EDS analysis. The morphology of SiO(2)(Car/Cs)(x) nanospheres and (Car/Cs)(x) nanocapsules were observed by TEM analysis. The size analysis of (Car/Cs)(x) nanocapsules indicated that the cyst wall thickness and cavity volume of the nanocapsules are pH and ionic strength dual responsive. Due to the biocompatibility of the natural polysaccharides carrageenan and chitosan and the responsiveness of nanocapsules to pH and ionic strength, the (Car/Cs)(x) multilayer nanocapsules are expected to be used as nanoreactors or nanocontainers to control the synthesis, encapsulation, and releasing behaviors of bioactive molecules.
authors.affiliation: School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Ziqi
authors.initials: Z
authors.lastname: Zhao
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Fanglian
authors.initials: F
authors.lastname: Yao
mesh_terms: D008567:Membranes, Artificial; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D053769:Nanocapsules; D011134:Polysaccharides; D012822:Silicon Dioxide