title: Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia.
abstract: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Bae
authors.forename: Mihyun
authors.initials: M
authors.lastname: Park
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Do
authors.forename: Nohyun
authors.initials: N
authors.lastname: Lee
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Ryu
authors.forename: Gun Woo
authors.initials: GW
authors.lastname: Kim
authors.forename: Cheolgi
authors.initials: C
authors.lastname: Kim
authors.forename: Tae Gwan
authors.initials: TG
authors.lastname: Park
authors.forename: Taeghwan
authors.initials: T
authors.lastname: Hyeon
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D004355:Drug Stability; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D008422:Materials Testing; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy*; D009844:Oligosaccharides / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D009844:Oligosaccharides; D048271:Chitosan