title: Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats.
abstract: Eryptosis is a term to define apoptosis of erythrocytes. Oxidative stress and hyperglycemia, both of which exist in the diabetic intravascular environment, can trigger eryptosis of erythrocytes. In this experimental study, it is presented that the majority of erythrocytes shows caspase-3 immunoreactivity in streptozocin- (STZ)-induced diabetic rats. Besides that, caspase-3 positive erythrocytes are aggregated and attached to vascular endothelium. In conclusion, these results may start a debate that eryptosis could have a role in the diabetic complications.
authors.affiliation: Department of Pathology, School of Medicine, Dicle University, Diyarbakır 21000, Turkey. dijlefirat@hotmail.com
authors.forename: Uğur
authors.initials: U
authors.lastname: Fırat
authors.forename: Savaş
authors.initials: S
authors.lastname: Kaya
authors.forename: Abdullah
authors.initials: A
authors.lastname: Cim
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Büyükbayram
authors.forename: Osman
authors.initials: O
authors.lastname: Gökalp
authors.forename: Mehmet Sinan
authors.initials: MS
authors.lastname: Dal
authors.forename: Mehmet Numan
authors.initials: MN
authors.lastname: Tamer
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D053148:Caspase 3 / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D053148:Caspase 3