title: Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease.
abstract: OBJECTIVE
  To observe the effects of Compound Danshen Tablets (CDST) on spatial cognition and expression of brain b-amyloid precursor protein (beta-APP) in a rat model of Alzheimer's disease.
  
  
  METHODS
  The rat model of Alzheimer's disease (AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage. Rat behavior was monitored using the Morris water maze, and the expression of beta-APP in rat brain tissue was detected via immunohistochemistry.
  
  
  RESULTS
  CDST significantly improved spatial cognition and decreased beta-APP expression in the cortex and hippocampus (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  CDST can significantly improve spatial cognition in a rat model of AD. This observation is possibly related to a reduction in beta-APP expression in the rat brain.
authors.affiliation: Modern Chinese Medicine Institute, Guangzhou Baiyunshan Hutchison Whampoa Chinese Medicine Co. Ltd., Guangdong 510515, China. qinrenan@813zy.com
authors.forename: Ren-An
authors.initials: RA
authors.lastname: Qin
authors.forename: Xiao-Xuan
authors.initials: XX
authors.lastname: Yao
authors.forename: Zhu-Ying
authors.initials: ZY
authors.lastname: Huang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D016564:Amyloid beta-Protein Precursor; D004365:Drugs, Chinese Herbal