title: Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin.
abstract: Microtermolides A (1) and B (2) were isolated from a Streptomyces sp. strain associated with fungus-growing termites. The structures of 1 and 2 were determined by 1D- and 2D-NMR spectroscopy and high-resolution mass spectrometry. Structural elucidation of 1 led to the re-examination of the structure originally proposed for vinylamycin (3). Based on a comparison of predicted and experimental (1)H and (13)C NMR chemical shifts, we propose that vinylamycin's structure be revised from 3 to 4.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Gavin
authors.initials: G
authors.lastname: Carr
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Klassen
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Hou
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Wyche
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: Cameron R
authors.initials: CR
authors.lastname: Currie
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001426:Bacterial Proteins / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D020049:Isoptera / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047630:Depsipeptides; C574709:microtermolide A; C574710:microtermolide B; C402693:vinylamycin