title: Sustained-release bupropion for smoking cessation in a Chinese sample: a double-blind, placebo-controlled, randomized trial.
abstract: BACKGROUND
  Bupropion is a first-line pharmacological aid for smoking cessation; however, no clinical trials have been conducted in a Chinese population.
  
  
  METHODS
  We enrolled 248 smokers in a hospital-based, randomized, smoking cessation trial conducted at four outpatient centers in Beijing. A total of 123 participants received an 8-week course of sustained-release bupropion (Bup-SR) and 125 participants received 8 weeks of placebo. All participants received brief education and counseling on smoking cessation. We determined rates of abstinence and smoking reduction based on chemical verification and self-report at 8 and 12 weeks.
  
  
  RESULTS
  At the end of the medication treatment (8 weeks) and at the end of the trial (12 weeks), the abstinence rates for Bup-SR were 29.3% and 39.8%, respectively, and 10.4% and 8.0% for placebo, respectively (both p < .001). Bup-SR was also superior to placebo in reducing cigarettes per day and urinary cotinine levels.
  
  
  CONCLUSIONS
  Bup-SR is efficacious for smoking cessation in healthy Chinese patients treated in the outpatient setting. It is well tolerated with a few mild side effects.
authors.affiliation: Beijing Anding Hospital, Capital Medical University, Beijing, China. shenglixia32@126.com
authors.forename: Li-xia
authors.initials: LX
authors.lastname: Sheng
authors.forename: Yi-lang
authors.initials: YL
authors.lastname: Tang
authors.forename: Zuo-ning
authors.initials: ZN
authors.lastname: Jiang
authors.forename: Chong-hua
authors.initials: CH
authors.lastname: Yao
authors.forename: Jun-yu
authors.initials: JY
authors.lastname: Gao
authors.forename: Guo-Zhu
authors.initials: GZ
authors.lastname: Xu
authors.forename: Xin-yuan
authors.initials: XY
authors.lastname: Tong
mesh_terms: D000328:Adult; D016642:Bupropion / Q000627:therapeutic use*; D002681:China; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D016540:Smoking Cessation; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D016642:Bupropion