title: [Investigation of antitumor substance from Trichoderma].
abstract: The effect of L-lysine-alpha-oxidase from Trichoderma harzianum Rifai on the functional activity of T-lymphocytes was investigated. It was shown that in a dose of 35 units/kg administered parentally the enzyme had no suppressive effect on the T-lymphocyte functional activity. An inhibitory effect of L-lysine-a-oxidase on some indices of the macrophages functional activity was observed. L-Lyzine-alpha-oxidase had a selective lymphotropic action and showed no mytostatic activity, which is in favour of the enzyme vs. other antitumor agents.
authors.forename: V M
authors.initials: VM
authors.lastname: Podboronov
authors.forename: A E
authors.initials: AE
authors.lastname: Kuzovnikov
authors.forename: A K
authors.initials: AK
authors.lastname: Zaĭtseva
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnova
authors.forename: T T
authors.initials: TT
authors.lastname: Berezov
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D056747:Immunomodulation; D007274:Injections, Intraperitoneal; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000187:drug effects*; D014242:Trichoderma / Q000201:enzymology*
chemical_list: D000970:Antineoplastic Agents; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase; D015720:5'-Nucleotidase