title: SMIP-016 in action: CD37 as a death receptor.
abstract: CD37 is a tetraspannin that triggers cell death and is a potential therapeutic target in cancers. In this issue of Cancer Cell, Lapalombella et al. show that CD37 is tyrosine phosphorylated following engagement by a bivalent engineered antibody fragment that binds CD37 and activates both SHP-1-dependent apoptotic signaling and PI3K-AKT-mediated survival signaling.
authors.affiliation: Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Immunology, University of Colorado School of Medicine and National Jewish Health Denver, Denver, CO 80206, USA. Electronic address: cambierj@njhealth.org.
authors.forename: John C
authors.initials: JC
authors.lastname: Cambier