title: A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis.
abstract: Toxic epidermal necrolysis represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Atorvastatin, a blood cholesterol-lowering agent, is a recognized cause of rhabdomyolysis; while naproxen, a widely used nonsteroidal anti-inflammatory drug, is a known cause of photo-induced skin lesions. We report the first fatal case of drug-induced toxic epidermal necrolysis associated with severe muscle necrosis due to the use of a nonsteroidal anti-inflammatory drug and a statin with very high levels of creatine phosphokinase leading to acute kidney injury, disseminated intravascular coagulation, and complete skin necrosis leading to death.
authors.affiliation: Department of Critical Care Medicine, Centre Hospitalier Universitaire de Tubize-Nivelles, 1400 Nivelles, Belgium. Sheikoaleed.Noordally@chu-brugmann.be
authors.forename: Sheik Oaleed
authors.initials: SO
authors.lastname: Noordally
authors.forename: Schoeb
authors.initials: S
authors.lastname: Sohawon
authors.forename: Julien
authors.initials: J
authors.lastname: Vanderhulst
authors.forename: Ruth
authors.initials: R
authors.lastname: Duttmann
authors.forename: Francis
authors.initials: F
authors.lastname: Corazza
authors.forename: Jacques
authors.initials: J
authors.lastname: Devriendt
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000069059:Atorvastatin; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*; D011758:Pyrroles / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D009288:Naproxen; D000069059:Atorvastatin