title: Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in rice field eel (Monopterus albus) after a single-dose intramuscular or oral administration.
abstract: The pharmacokinetics of florfenicol (FF) and its metabolite, florfenicol amine (FFA), were studied in rice field eel (Monopterus albus) after a single dose (20 mg/kg) by intramuscular (i.m.) or oral gavage (p.o.) dose at 25 °C. The elimination half-lives (t1/2β ), peak concentration of FF (Cmax ), and time to reach FF peak concentration (Tmax ) in plasma were estimated as 18.39 h, 10.83 μg/mL, and 7.00 h, respectively, after i.m. injection and 13.46 h, 8.37 μg/mL, and 5 h, respectively, after p.o. administration. The Tmax values of FF in tissues (i.e., kidney, muscle, and liver) were larger for i.m. injection compared with those for p.o. administration. The t1/2β had the following order kidney>muscle>liver for i.m. administrated and kidney>liver>muscle for p.o. administrated. The largest area under the concentration-time curve (AUC) was calculated to be 384.29 mg·h/kg after i.m. dosing, and the mean residence time (MRT) was 42.46 h by oral administration in kidney. FFA was also found in all tissues with a lower concentration than FF for both i.m. and p.o. administrations throughout the study. The elimination of FFA was slow with a t1/2β between 18.19 and 47.80 h in plasma and tissues. The mean metabolic rate of FFA for i.m. and p.o. administrations was >23.30%.
authors.affiliation: College of fisheries, Huazhong Agricultural University, Wuhan, China.
authors.forename: L-L
authors.initials: LL
authors.lastname: Xie
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Wu
authors.forename: X-X
authors.initials: XX
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Yuan
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D023701:Smegmamorpha / Q000378:metabolism*; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: C035534:florfenicol; D013839:Thiamphenicol