title: Synthesis and antimicrobial activity of new substituted thienopyrimidines, their tetrazolyl and sugar derivatives.
abstract: A series of substituted 5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidine-4-one derivatives were newly synthesized starting from 5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidine-4-one derivatives (1). Furthermore, their derived tetrazolyl as well as the N-substituted derivatives were also prepared. The antimicrobial activity of the prepared compounds against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans were evaluated. The substituted thienopyrimidine derivatives 4 and 6 as well as the arylidine 10 were the highly active compounds.
authors.affiliation: Department of Chemistry, Faculty of Science, NBU University, Kingdom of Saudi Arabia. waelshendy@gmail.com
authors.forename: Wael A
authors.initials: WA
authors.lastname: El-Sayed
authors.forename: Omar M
authors.initials: OM
authors.lastname: Ali
authors.forename: Rihana A F
authors.initials: RA
authors.lastname: Zyada
authors.forename: Asem A
authors.initials: AA
authors.lastname: Mohamed
authors.forename: Adel A H
authors.initials: AA
authors.lastname: Abdel-Rahman
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002241:Carbohydrates / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D002241:Carbohydrates; D011743:Pyrimidines; C476003:thienopyrimidine