title: Fractionated stereotactic conformal radiotherapy for optic nerve sheath meningiomas.
abstract: OBJECTIVE
  To assess visual outcome, tumour control and treatment-related morbidity in patients with optic nerve sheath meningiomas (ONSMs) treated with fractionated stereotactic radiotherapy (FSRT).
  
  
  METHODS
  A retrospective analysis of 45 patients (13 men and 32 women, median age 46 years) with ONSMs (51 optic nerves involved) treated in a single institution between 1997 and 2010 was carried out. FSRT was delivered to a dose of 50 Gy in 30 or 33 fractions as primary treatment in 39 patients and after surgery in six patients.
  
  
  RESULTS
  At a median follow-up of 30 months (range 1-13 years), the tumour control in 41 evaluable patients (four were lost to follow-up) was 100% at 5 years with no subsequent local or distant recurrence. Of the 46 evaluable optic nerves treated, 41 had residual vision (38 with impaired vision) before radiotherapy and five were blind in one eye. There was no recovery of vision in any of the blind eyes. Of 41 optic nerves with residual vision, 13 had improvement, 24 remained stable and four deteriorated; two patients (4%) developed radiation retinopathy. One patient developed a central retinal artery occlusion in the untreated eye 10 years after treatment.
  
  
  CONCLUSIONS
  FSRT is highly effective at controlling the growth of ONSMs with improvement or stabilisation of visual deficit in 89% of the optic nerves retaining some vision, albeit with a small risk of radiation-induced retinopathy. The results support the use of FSRT as an effective approach in the management of ONSM. The lack of functional benefit in patients with severe visual impairment would argue for earlier institution of treatment before complete visual loss is established.
authors.affiliation: Neuro-Oncology Unit, The Royal Marsden NHS Foundation Trust, London and Sutton, UK.
authors.forename: F
authors.initials: F
authors.lastname: Soldà
authors.forename: B
authors.initials: B
authors.lastname: Wharram
authors.forename: R
authors.initials: R
authors.lastname: Gunapala
authors.forename: M
authors.initials: M
authors.lastname: Brada
mesh_terms: D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D019574:Optic Nerve Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D020266:Radiotherapy, Conformal / Q000379:methods; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D016019:Survival Analysis; D016896:Treatment Outcome