title: Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy: in-water synthesis of "difficult sequences".
abstract: A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.
authors.affiliation: Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chou-ku, Kobe, Japan. hojo@pharm.kobegakuin.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Hojo
authors.forename: Hideki
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Asaki
authors.initials: A
authors.lastname: Hara
authors.forename: Mare
authors.initials: M
authors.lastname: Onishi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fukumori
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D008872:Microwaves; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; D014867:Water