title: Influence of chemical peeling on the skin stress response system.
abstract: Skin stress response system (SSRS) involves corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC)-derived peptides, such as adrenocorticotropic hormone (ACTH), a-melanocyte-stimulating hormone (MSH) and b-endorphin that are locally generated in response to locally provided stressors or proinflammatory cytokines. This system would restrict tissue damage and restore local homoeostasis. Trichloroacetic acid (TCA) is one of the most widely used peeling agents and applied for cosmetic treatment of photodamaged skin. However, the biological mechanism responsible for TCA peeling has yet to be fully determined. While our investigation focused on the inflammation and wound healing pathways, in the recent study, we have examined involvement of the SSRS as the third pathway. Mostly depending on our findings that TCA peeling activates the SSRS by inducing the POMC expression of keratinocytes in the CRH-independent manner, together with the results reported by other researchers, we can say that the biological effect of POMC seems to be responsible for the TCA-induced epidermal SSRS activation.
authors.affiliation: Department of Dermatology, Naga Municipal Hospital, Wakayama, Japan. kimura@nagahp.jp
authors.forename: Ayako
authors.initials: A
authors.lastname: Kimura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kanazawa
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Li
authors.forename: Nozomi
authors.initials: N
authors.lastname: Yonei
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002615:Chemexfoliation / Q000009:adverse effects* / Q000379:methods; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D015603:Keratinocytes / Q000166:cytology; D010455:Peptides / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012879:Skin Physiological Phenomena; D000521:alpha-MSH / Q000378:metabolism
chemical_list: D004723:Endorphins; D010455:Peptides; D012333:RNA, Messenger; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone