title: Compared to dinoprost tromethamine, cloprostenol sodium increased rates of estrus detection, conception and pregnancy in lactating dairy cows on a large commercial dairy.
abstract: Using two PGF(2α) treatments 14 days apart as a way to enhance estrus detection rate following the 2nd treatment is a reproductive management tool that continues to be used on large dairy farms. In one study, in cows with a functional CL and a dominant follicle, treatment with cloprostenol vs. dinoprost resulted in greater peripheral estradiol concentrations. The objective of the present study was to determine if cloprostenol could enhance pregnancy rates of cows in a large dairy herd using a PGF(2α) program for 1st artificial insemination (AI). Lactating dairy cows (n = 4549) were randomly assigned to receive two treatments of either 500 μg cloprostenol or 25 mg dinoprost 14 days apart, with the 2nd treatment on the 1st day of the voluntary waiting period (57 DIM). Cows detected in estrus within 5 days after the 2nd treatment were inseminated. There was no effect of treatment on day of estrus detection, with 78% of cows inseminated on Days 3 or 4 following treatment. Cloprostenol increased (P < 0.01) estrus detection rates in 1st parity cows compared to dinoprost, 42.4 vs. 34.0%. In cows inseminated on Days 3 or 4 after treatment, cloprostenol increased (P = 0.05) conception rates compared to dinoprost, 38.3 vs. 34.4%. When treatments and parities were combined, conception rates increased (P < 0.02) with interval after treatment (27.0, 36.4, and 44.5% for Days 1 or 2, Days 3 or 4, and Day 5, respectively). Cloprostenol increased (P = 0.02) overall pregnancy rate compared to dinoprost, 14.4 vs. 12.2%. In summary, cloprostenol increased fertility in 1st parity cows inseminated on Days 3 or 4 following treatment and subsequently enhanced pregnancy rates of 1st parity lactating dairy cows compared to dinoprost. Fertility appeared greater in cows expected to have had a young antral ovarian follicle at treatment.
authors.affiliation: Department of Animal Science, Michigan State University, East Lansing, Michigan, USA. pursleyr@msu.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Pursley
authors.forename: J P N
authors.initials: JP
authors.lastname: Martins
authors.forename: C
authors.initials: C
authors.lastname: Wright
authors.forename: N D
authors.initials: ND
authors.lastname: Stewart
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology; D003008:Cloprostenol / Q000494:pharmacology / Q000627:therapeutic use*; D003132:Commerce; D003612:Dairying; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004972:Estrus Detection / Q000379:methods*; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D007774:Lactation / Q000187:drug effects / Q000502:physiology; D008186:Luteolytic Agents / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D018873:Pregnancy Rate; D011270:Pregnancy, Animal / Q000187:drug effects*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D008186:Luteolytic Agents; D003008:Cloprostenol; D015237:Dinoprost; C010714:dinoprost tromethamine