title: Making preventive medicine more personalized: implications for exercise-related research.
abstract: OBJECTIVE
  This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine.
  
  
  METHODS
  We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training.
  
  
  RESULTS
  We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions.
  
  
  CONCLUSIONS
  Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care.
authors.affiliation: Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL 32611, USA. tbuford@ufl.edu
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Buford
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
mesh_terms: D003159:Community-Institutional Relations; D015444:Exercise / Q000523:psychology; D023281:Genomics; D019983:Guideline Adherence; D015438:Health Behavior; D006291:Health Policy; D006293:Health Promotion / Q000379:methods*; D006302:Health Services Research; D006801:Humans; D009936:Organizational Innovation; D010043:Outcome and Process Assessment, Health Care; D010597:Pharmacogenetics; D010817:Physician-Patient Relations; D057285:Precision Medicine / Q000706:statistics & numerical data*; D011315:Preventive Medicine / Q000379:methods* / Q000639:trends; D014481:United States