title: Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population.
abstract: Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.
authors.affiliation: Research Center for Standardization of Allergic Disease, Korea National Institute of Health, Osong 363-951, Korea.
authors.forename: Dankyu
authors.initials: D
authors.lastname: Yoon
authors.forename: Hyo-Jeong
authors.initials: HJ
authors.lastname: Ban
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Hyung-Cheo
authors.initials: HC
authors.lastname: Kim
authors.forename: Bok-Ghe
authors.initials: BG
authors.lastname: Han
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Park
authors.forename: Soo-Jong
authors.initials: SJ
authors.lastname: Hong
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Cho
authors.forename: Kiejung
authors.initials: K
authors.lastname: Park
authors.forename: Joo-Shil
authors.initials: JS
authors.lastname: Lee
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study / Q000592:standards / Q000706:statistics & numerical data; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D056910:Republic of Korea / Q000453:epidemiology