title: The Rabe amination after a century: direct addition of N-heterocycles to carbonyl compounds.
abstract: A catalytic version of the Rabe electrophilic amination is presented. This kind of reaction was originally employed in 1918 in a key step for the conversion of quinotoxine to quinine. Ketones and α-substituted aldehydes give the corresponding α-aminated carbonyl compounds in moderate yield. α,α-Unsubstituted aldehydes give rise to amino ketones via a novel rearrangement.
authors.affiliation: Dipartimento di Chimica, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Roma, Italy.
authors.forename: Daniele M
authors.initials: DM
authors.lastname: Scarpino Schietroma
authors.forename: Mattia R
authors.initials: MR
authors.lastname: Monaco
authors.forename: Valerio
authors.initials: V
authors.lastname: Bucalossi
authors.forename: Philipp E
authors.initials: PE
authors.lastname: Walter
authors.forename: Patrizia
authors.initials: P
authors.lastname: Gentili
authors.forename: Marco
authors.initials: M
authors.lastname: Bella