title: Office microlaparoscopic intrafallopian transfer of day one zygote versus day three embryo transfer after previous failed ICSI trials.
abstract: The objective of the study was to investigate whether transferring zygotes on day 1 would result in similar pregnancy rates compared to transferring cleavage stage embryos on day 3 in a prospective randomized trial, using the office microlaparoscopic procedure. Patients undergoing IVF/ICSI treatments were randomized to either day 1 or day 3 transfers after previous failed ICSI trials due to failed implantation. The primary outcome measure was pregnancy rate. Pregnancy rates were higher in day 3 group (55/131, 42%) when compared to day 1 (34/123, 28%, P = 0.024). Similarly, implantation rates were higher in day 3 group (P = 0.03). There were more cycles with cryopreservation in the day 1 group (P < 0.001). Embryo quality on day 3 was similar between pattern 0 and non-pattern 0 zygotes. Day 3 embryo transfers result in better pregnancy and implantation rates compared to day 1 zygote transfers.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, El-Minya University, El-Minya University Hospital, Egypt. eemsalah@yahoo.com
authors.forename: Emad M
authors.initials: EM
authors.lastname: Siam
mesh_terms: D000328:Adult; D015925:Cryopreservation / Q000379:methods*; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000009:adverse effects / Q000379:methods / Q000592:standards; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000379:methods / Q000592:standards; D006801:Humans; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects / Q000379:methods; D013997:Time Factors; D015053:Zygote / Q000254:growth & development*; D017388:Zygote Intrafallopian Transfer / Q000379:methods