title: Chylothorax after congenital diaphragmatic hernia repair: a population-based study.
abstract: OBJECTIVE
  Chylothorax is a recognized complication of congenital diaphragmatic hernia (CDH) repair. Our aims were to describe the frequency and outcomes of chylothorax and to seek predictors of chylothorax occurrence within a population-based CDH cohort.
  
  
  METHODS
  Records for patients with CDH born between 2006 and 2010 were abstracted from a national database and were compared according to presence/absence of postrepair chylothorax. Univariate, and where appropriate, multivariate analyses were performed for group comparisons and chylothorax outcome prediction.
  
  
  RESULTS
  Of 243 newborns with CDH surviving to repair, 11 (4.5%) developed a chylothorax. All were managed nonoperatively. Factors predictive of chylothorax outcome on multivariate analysis included need for preoperative transfusion (odds ratio, 13.2; 95% confidence interval, 2.1-83.7; P = .006) and preoperative high-frequency oscillatory ventilation (odds ratio, 7.1; 95% confidence interval, 1.6-31.2; P = .01). Preoperative vasopressor use was significant on univariate analysis only. The groups were comparable for survival, length of stay, and duration of ventilation, but chylothorax patients had prolonged total parenteral nutrition (53 vs 21 days, P = .006) and more central line days (46 vs 24 days, P = .03).
  
  
  CONCLUSIONS
  Our data suggest that severity of preoperative cardiopulmonary derangement and not anatomical or technical factors predicts chylothorax occurrence after CDH repair.
authors.affiliation: Department of Surgery, BC Children's Hospital and the University of British Columbia, Vancouver, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mills
authors.forename: Arash
authors.initials: A
authors.lastname: Safavi
authors.forename: Erik D
authors.initials: ED
authors.lastname: Skarsgard
mesh_terms: D002916:Chylothorax / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D006548:Hernia, Diaphragmatic / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D059685:Herniorrhaphy; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D016896:Treatment Outcome