title: Synthesis of 1,1-diarylethylenes via efficient iron/copper co-catalyzed coupling of 1-arylvinyl halides with Grignard reagents.
abstract: An efficient access to 1,1-diarylethylenes of biological interest by coupling functionalized aryl Grignard reagents and 1-arylvinyl halides in the presence of FeCl(3)/CuTC is described. This bimetallic system proved to be superior to the use of Fe or Cu catalyst alone. The synthetic utility of this protocol is illustrated in the field of steroid chemistry.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, 5 Rue J. B. Clément, Châtenay-Malabry, F-92296, France. abdallah.hamze@u-psud.fr
authors.forename: Abdallah
authors.initials: A
authors.lastname: Hamze
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.forename: Mouad
authors.initials: M
authors.lastname: Alami
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005030:Ethylenes / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D005030:Ethylenes; D006846:Hydrocarbons, Halogenated; D007202:Indicators and Reagents; D003300:Copper; D007501:Iron