title: The importance of animal models in tuberculosis vaccine development.
abstract: Research, development, and production of vaccines are still highly dependent on the use of animal models in the various evaluation steps. Despite this fact, there are strong interests and ongoing efforts to reduce the use of animals in vaccine development. Tuberculosis vaccine development is one important example of the complexities involved in the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, as well as achievements and challenges towards the rational use of animals, particularly in the case of tuberculosis vaccine development.
authors.affiliation: Instituto Finlay, PO Box 16017, Cod 11600, La Habana, Cuba.
authors.forename: Armando
authors.initials: A
authors.lastname: Acosta
authors.forename: Mohd Nor
authors.initials: MN
authors.lastname: Norazmi
authors.forename: Rogelio
authors.initials: R
authors.lastname: Hernandez-Pando
authors.forename: Nadine
authors.initials: N
authors.lastname: Alvarez
authors.forename: Reinier
authors.initials: R
authors.lastname: Borrero
authors.forename: Juan F
authors.initials: JF
authors.lastname: Infante
authors.forename: Maria E
authors.initials: ME
authors.lastname: Sarmiento