title: Clinical significance of impaired cerebrovascular autoregulation after severe aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  The purpose of this study was to investigate the relationship between cerebrovascular autoregulation and outcome after aneurysmal subarachnoid hemorrhage.
  
  
  METHODS
  In a prospective observational study, 80 patients after severe subarachnoid hemorrhage were continuously monitored for cerebral perfusion pressure and partial pressure of brain tissue oxygen for an average of 7.9 days (range, 1.9-14.9 days). Autoregulation was assessed using the index of brain tissue oxygen pressure reactivity (ORx), a moving correlation coefficient between cerebral perfusion pressure and partial pressure of brain tissue oxygen. High ORx indicates impaired autoregulation; low ORx signifies intact autoregulation. Outcome was determined at 6 months and dichotomized into favorable (Glasgow Outcome Scale 4-5) and unfavorable outcome (Glasgow Outcome Scale 1-3).
  
  
  RESULTS
  Twenty-four patients had a favorable and 56 an unfavorable outcome. In a univariate analysis, there were significant differences in autoregulation (ORx 0.19±0.10 versus 0.37±0.11, P<0.001, for favorable versus unfavorable outcome, respectively), age (44.1±11.0 years versus 54.2±12.1 years, P=0.001), occurrence of delayed cerebral infarction (8% versus 46%, P<0.001), use of coiling (25% versus 54%, P=0.02), partial pressure of brain tissue oxygen (24.9±6.6 mm Hg versus 21.8±6.3 mm Hg, P=0.048), and Fisher grade (P=0.03). In a multivariate analysis, ORx (P<0.001) and age (P=0.003) retained an independent predictive value for outcome. ORx correlated with Glasgow Outcome Scale (r=-0.70, P<0.001).
  
  
  CONCLUSIONS
  The status of cerebrovascular autoregulation might be an important pathophysiological factor in the disease process after subarachnoid hemorrhage, because impaired autoregulation was independently associated with an unfavorable outcome.
authors.affiliation: Department of Neurosurgery, University of Leipzig, Leipzig, Germany. matthias.jaeger@sswahs.nsw.gov.au
authors.forename: Matthias
authors.initials: M
authors.lastname: Jaeger
authors.forename: Martin
authors.initials: M
authors.lastname: Soehle
authors.forename: Martin U
authors.initials: MU
authors.lastname: Schuhmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Meixensberger
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015901:Angiography, Digital Subtraction; D001794:Blood Pressure / Q000502:physiology; D002544:Cerebral Infarction / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000503:physiopathology*; D057510:Endovascular Procedures; D005260:Female; D023261:Glasgow Outcome Scale; D006706:Homeostasis; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D012044:Regression Analysis; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000503:physiopathology* / Q000601:surgery; D013525:Surgical Instruments; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D010100:Oxygen