title: A phenomenological model for chemico-mechanically induced cell shape changes during migration and cell-cell contacts.
abstract: A phenomenological model for the evolution of shape transition of cells is considered. These transitions are determined by the emission of growth-factors, as well as mechanical interaction if cells are subjected to hard impingement. The originality of this model necessitates a formal treatment of the mathematical model, as well as the presentation of elementary cases in order to illustrate the consistence of the model. We will also show some small-scale relevant applications.
authors.affiliation: Delft Institute of Applied Mathematics, Delft University of Technology, Delft, The Netherlands. F.J.Vermolen@tudelft.nl
authors.forename: F J
authors.initials: FJ
authors.lastname: Vermolen
authors.forename: A
authors.initials: A
authors.lastname: Gefen
mesh_terms: D000818:Animals; D001419:Bacteria / Q000166:cytology; D002450:Cell Communication; D002452:Cell Count; D002465:Cell Movement; D016764:Cell Polarity; D048430:Cell Shape; D003198:Computer Simulation; D005347:Fibroblasts / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D041681:NIH 3T3 Cells; D013314:Stress, Mechanical; D013997:Time Factors