title: Real-time stochastic detection of multiple neurotransmitters with a protein nanopore.
abstract: The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.
authors.affiliation: Department of Chemistry, University of Oxford, Oxford, OX1 3TA, United Kingdom.
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Boersma
authors.forename: Keith L
authors.initials: KL
authors.lastname: Brain
authors.forename: Hagan
authors.initials: H
authors.lastname: Bayley
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003217:Conductometry / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000032:analysis*; D016062:Porosity; D025941:Protein Interaction Mapping / Q000379:methods*; D013269:Stochastic Processes
chemical_list: D018377:Neurotransmitter Agents; D003300:Copper