title: Plasma fluorescent oxidation products and short-term occupational particulate exposures.
abstract: BACKGROUND
  Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage.
  
  
  METHODS
  A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications.
  
  
  RESULTS
  The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) .
  
  
  CONCLUSIONS
  Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. jaime.hart@channing.harvard.edu
authors.forename: Jaime E
authors.initials: JE
authors.lastname: Hart
authors.forename: Tianying
authors.initials: T
authors.lastname: Wu
authors.forename: Francine
authors.initials: F
authors.lastname: Laden
authors.forename: Eric
authors.initials: E
authors.lastname: Garshick
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D015415:Biomarkers; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018986:Motor Vehicles; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D052638:Particulate Matter / Q000009:adverse effects*; D012307:Risk Factors; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D052638:Particulate Matter; D001335:Vehicle Emissions