title: Active drug targeting of disease by nanoparticles functionalized with ligand to folate receptor.
abstract: Drug-loaded nanoparticles have shown great potential in the study of carriers for disease-targeting drug delivery. Drug-loaded nanoparticles are excellent in keeping the drug in the systemic circulation for a prolonged period of time, introducing targeting molecules to improve targeting efficiency and to reduce side effects. A general review on active drug targeting of cancerous diseases by nanoparticles functionalized with ligands to folate receptors is presented including the (1) materials and methods for nanoparticle preparation, (2) methods for drug encapsulation, (3) surface functionalization of the nanoparticle with ligand to folate receptors, and (4) in vitro and in vivo experiments.
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China.
authors.forename: Q
authors.initials: Q
authors.lastname: Tu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: J-C
authors.initials: JC
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Nie
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Ren
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D005492:Folic Acid / Q000378:metabolism; D058972:Folic Acid Transporters / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D058972:Folic Acid Transporters; D008024:Ligands; D005492:Folic Acid