title: A perspective on the selection of unrelated donors and cord blood units for transplantation.
abstract: Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient HLA matching to ensure engraftment and acceptable rates of GVHD. In this Perspective, the National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research provide guidelines, based on large studies correlating graft characteristics with clinical transplantation outcomes, on appropriate typing strategies and matching criteria for unrelated adult donor and cord blood graft selection.
authors.affiliation: Center for International Blood and Marrow Transplant Research, Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Ave., Milwaukee, WI 53226, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Spellman
authors.forename: Mary
authors.initials: M
authors.lastname: Eapen
authors.forename: Brent R
authors.initials: BR
authors.lastname: Logan
authors.forename: Carlheinz
authors.initials: C
authors.lastname: Mueller
authors.forename: Pablo
authors.initials: P
authors.lastname: Rubinstein
authors.forename: Michelle I
authors.initials: MI
authors.lastname: Setterholm
authors.forename: Ann E
authors.initials: AE
authors.lastname: Woolfrey
authors.forename: Mary M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
authors.forename: Carolyn K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000637:transplantation; D036101:Cord Blood Stem Cell Transplantation / Q000592:standards*; D046148:Donor Selection / Q000592:standards* / Q000706:statistics & numerical data; D018380:Hematopoietic Stem Cell Transplantation / Q000592:standards*; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D036102:Peripheral Blood Stem Cell Transplantation / Q000592:standards; D014019:Tissue Donors; D014181:Transplantation Immunology; D014481:United States