title: Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease.
abstract: Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5- and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.
authors.affiliation: Institute for Clinical Research, and Department of Pediatrics, Mie National Hospital, Tsu, Japan.
authors.forename: Koa
authors.initials: K
authors.lastname: Hosoki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirayama
authors.forename: Gail M
authors.initials: GM
authors.lastname: Kephart
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kita
authors.forename: Mizuho
authors.initials: M
authors.lastname: Nagao
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Uchizono
authors.forename: Hidemi
authors.initials: H
authors.lastname: Toyoda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Senba
authors.forename: Yu
authors.initials: Y
authors.lastname: Imai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Komada
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ihara
authors.forename: Takao
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008297:Male
chemical_list: D016207:Cytokines