title: Polyphenolic acetylcholinesterase inhibitors from Hopea chinensis.
abstract: Bioassay-guided investigation of the stem bark of Hopea chinensis led to the isolation of two new polyphenols, hopeachinols C(1) and D(2), together with ten known compounds (3-12). Compounds 1 and 2 were determined by extensive analysis of spectroscopic data and computational methods. All of these phytochemicals were tested for acetylcholinesterase inhibitory activity, and five resveratrol-derived compounds (1 and 7-10) exhibited significant activity with their IC₅₀ values ranging from 4.81 to 11.71 µM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Yan
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.forename: Yan Hua
authors.initials: YH
authors.lastname: Qin
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005591:Chemical Fractionation / Q000379:methods; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019295:Computational Biology / Q000379:methods; D053958:Dipterocarpaceae / Q000737:chemistry*; D057075:Enzyme Assays / Q000379:methods; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry
chemical_list: D001572:Benzofurans; D002800:Cholinesterase Inhibitors; D059808:Polyphenols; D013267:Stilbenes; C575887:hopeachinol C; C575888:hopeachinol D; C064176:alpha-viniferin; D000077185:Resveratrol