title: Curcumin inhibits tongue carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10.
abstract: Squamous cell carcinoma (SCC) of tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in tongue carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on tongue carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to tongue cancer cells migration and invasion.
authors.affiliation: Department of Surgery, The University of Hong Kong, SAR China.
authors.forename: Raymond King-Yin
authors.initials: RK
authors.lastname: Tsang
authors.forename: Whitney Wing-Yan
authors.initials: WW
authors.lastname: Tang
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Wai-Kuen
authors.initials: WK
authors.lastname: Ho
authors.forename: Jimmy Yu-Wai
authors.initials: JY
authors.lastname: Chan
authors.forename: William Ignace
authors.initials: WI
authors.lastname: Wei
authors.forename: Thian-Sze
authors.initials: TS
authors.lastname: Wong
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology; D015536:Down-Regulation; D006801:Humans; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; C511770:MMP10 protein, human; D053506:Matrix Metalloproteinase 10; D003474:Curcumin