title: Animal model of dermatophytosis.
abstract: Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host's normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatophytosis and evaluate drug efficacy. However, current animal models have several issues. In the present paper, we surveyed reports about the methodology of the dermatophytosis animal model for tinea corporis, tinea pedis, and tinea unguium and discussed future prospects.
authors.affiliation: R&D Laboratories, POLA Pharma Inc, 560 Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shimamura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kubota
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D014005:Tinea