title: Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.
abstract: Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.
authors.affiliation: Duke Cancer Institute, Durham, NC 27710, USA.
authors.forename: Allison S
authors.initials: AS
authors.lastname: Betof
authors.forename: Mark W
authors.initials: MW
authors.lastname: Dewhirst
authors.forename: Lee W
authors.initials: LW
authors.lastname: Jones
mesh_terms: D000818:Animals; D018450:Disease Progression; D005081:Exercise Therapy; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010805:Physical Conditioning, Animal; D011379:Prognosis; D016896:Treatment Outcome