title: Multidrug-resistant tuberculosis that required 2 years for diagnosis.
abstract: Isoniazid (H) or rifampicin (R) mono-resistant disease can be treated easily and effectively with first-line drugs, while combined H and R resistance (ie, multidrug-resistant tuberculosis (MDRTB)) requires treatment with at least four agents, including a quinolone and an injectable agent. Drug-resistant Mycobacterium tuberculosis strains are reported to be extremely difficult to cultivate invitro. The authors report a case of MDRTB that required 2 years for diagnosis, and was detected only in sputum culture on solid medium. Physicians should consider MDRTB if TB is suspected but pathogens are not detected.
authors.affiliation: National Hospital Organization Matsue Medical Centre, Matsue, Japan. yano@matsue.hosp.go.jp
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yano
authors.forename: Kanako
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D010131:Aminosalicylic Acid / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000627:therapeutic use; D011718:Pyrazinamide / Q000627:therapeutic use; D013183:Sputum / Q000382:microbiology; D013307:Streptomycin / Q000627:therapeutic use; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D010131:Aminosalicylic Acid; D015242:Ofloxacin; D013307:Streptomycin