title: Molecular biologic assessment of cutaneous specimens of ocular rosacea.
abstract: OBJECTIVE
  To characterize the molecular biologic environment of pathological skin in ocular rosacea and to differentiate the levels of inflammatory molecules in ocular rosacea from those of normal skin.
  
  
  METHODS
  The concentrations of 48 molecules were assayed in cutaneous biopsies taken from patients with ocular rosacea and from normal controls.
  
  
  RESULTS
  There were very few molecular differences between the 2 groups, and 43 of the 48 molecules that were measured in this study were not significantly different between the 2 groups. The concentrations of 5 molecules (interleukin-1β, interleukin-16, stem cell factor, monocyte chemotactic protein-1, and monokine induced by γ-interferon) were significantly enriched in ocular rosacea.
  
  
  CONCLUSIONS
  Ocular rosacea is a highly ordered molecular process and involves elevations in the concentrations of specific molecules. The particular pattern of enrichment supports the notion that ocular rosacea represents a disorder of innate immunity. Furthermore, these molecules may represent novel therapeutic targets in the future management of this disorder.
authors.affiliation: Ophthalmic Plastic Surgery, Department of Ophthalmology, Albany Medical College, Albany, New York, USA. tedwladis@gmail.com
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Wladis
authors.forename: Bibiana V
authors.initials: BV
authors.lastname: Iglesias
authors.forename: Alejandro P
authors.initials: AP
authors.lastname: Adam
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Gosselin
mesh_terms: D001706:Biopsy; D018932:Chemokine CCL2 / Q000378:metabolism*; D054370:Chemokine CXCL9 / Q000378:metabolism*; D005260:Female; D006801:Humans; D019410:Interleukin-16 / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology; D012393:Rosacea / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D019089:Stem Cell Factor / Q000378:metabolism*
chemical_list: C111835:CCL2 protein, human; C080810:CXCL9 protein, human; D018932:Chemokine CCL2; D054370:Chemokine CXCL9; D019410:Interleukin-16; D053583:Interleukin-1beta; D019089:Stem Cell Factor