title: Absence of SH2B3 mutation in nonobese diabetic mice.
abstract: Type 1 diabetes is a chronic progressive autoimmune  disease characterized by mononuclear cell infiltration, with subsequent  destruction of insulin-producing β-cells. Studies have identified strong associations  between type 1 diabetes and several chromosome regions, including 12q24.  Association between type 1 diabetes and 12q24 arises from SNP rs3184504;  rs3184504 is a nonsynonymous SNP in exon 3 of SH2B3 (also known as LNK).  Nonobese diabetic (NOD) mice recapitulate many aspects of the pathogenesis of  type 1 diabetes in humans and are therefore frequently used in studies  addressing the cellular and molecular mechanisms of this disease. It is of  interest to know whether there is a similar mutation of SH2B3 in NOD  mice. We found that the SH2B3 mutation is absent in NOD mice. To our knowledge,  this is the first report of the sequence and the protein levels of SH2B3 in NOD  mice.
authors.affiliation: Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, PR China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Li
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.forename: X R
authors.initials: XR
authors.lastname: Guo
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: B F
authors.initials: BF
authors.lastname: Shen
authors.forename: Y C
authors.initials: YC
authors.lastname: Shi
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D009154:Mutation; D009765:Obesity; D020641:Polymorphism, Single Nucleotide
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D017931:DNA Primers; D047908:Intracellular Signaling Peptides and Proteins; C490777:Lnk protein, mouse; D008565:Membrane Proteins