title: mTHPC--a drug on its way from second to third generation photosensitizer?
abstract: 5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.
authors.affiliation: Medicinal Chemistry, Institute of Molecular Medicine, Trinity Centre for Health Sciences, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland. sengem@tcd.ie
authors.forename: Mathias O
authors.initials: MO
authors.lastname: Senge
mesh_terms: D006801:Humans; D008652:Mesoporphyrins / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends*; D017319:Photosensitizing Agents / Q000627:therapeutic use
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin