title: Interaction between regulatory T cells and cancer stem cells.
abstract: The concept that cancer stem cells (CSCs)/tumor stem cells/cancer-initiating cells are one of the key centers to cure neoplastic disease has drawn an increasing attention recent years. Because of their high resistance and potential to initiate tumors, CSCs are considered a critical factor associated with tumor relapse. Regulatory T(T(reg)) cells, a group of immune cells with tumor-promoting effect, exert their function through inhibition of effector T cells and regulation of the tumor microenvironment by producing a series of soluble factors. However, the interactions between T(reg)s and CSCs are less understood. The mechanisms of how T(reg)s, as tumor-promoting cells, manipulate CSCs remain obscure. In this review, we elucidate their interactions.
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China.
authors.forename: Xiaozhou
authors.initials: X
authors.lastname: Yu
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D000818:Animals; D002450:Cell Communication; D058750:Epithelial-Mesenchymal Transition; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D051858:Forkhead Transcription Factors; D016212:Transforming Growth Factor beta