title: Axis of ageing: telomeres, p53 and mitochondria.
abstract: Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.
authors.affiliation: Huffington Center On Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. esahin@bcm.edu
authors.forename: Ergün
authors.initials: E
authors.lastname: Sahin
authors.forename: Ronald A
authors.initials: RA
authors.lastname: DePinho
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D016615:Telomere / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53