title: [Mature eggs from primordial follicles in vitro--a challenge in the near future].
abstract: In vitro maturation of eggs from frozen-preserved tissue would be an important infertility therapy for women, whose eggs have been destroyed during cancer treatment. If there is a risk of presence of malignant cells in the tissue, it cannot be transferred back to the woman. Almost full-sized eggs are obtained in ovarian tissue culture by abolishing inhibition of the activation of ovarian follicles and by adding growth-regulating growth factors and hormones. Their final maturation in the subsequent culture and fertilization will hopefully be successful in the near future.
authors.affiliation: Karoliininen instituutti, Tukholma.
authors.forename: Outi
authors.initials: O
authors.lastname: Hovatta
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009865:Oocytes / Q000254:growth & development*; D009866:Oogenesis / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology / Q000254:growth & development*; D012099:Reproductive Techniques