title: Determinants of brachial-ankle pulse wave velocity in a Japanese population: a cohort study.
abstract: Arterial stiffness is one of the biggest predictors of coronary heart disease (CHD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) are correlated with risk factors of CHD. All of the 528 participants (270 males and 258 females) in this study were healthy workers aged from 36 to 69 (mean age: 47.9 ± 8.1 years). The Framingham Risk Score (FRS) showed a good correlation with baPWV (r = 0.53, p < 0.01), indicating that FRS is also applicable as an index of arterial stiffness in Japanese people. Blood pressures were well controlled in patients with medical treatment for hypertension; however, vessels remained relatively still stiff, whereas the AI was considerably low. Multivariate linear regression analysis showed that factors of such as FRS, body mass index, alcohol consumption and AI P75 were significantly correlated with baPWV.
authors.affiliation: Unit for Liveable Cities, Kyoto University Graduate School of Medicine, Kyoto, Japan. mitani-satoko@hs.med.kyoto-u.ac.jp
authors.forename: Satoko
authors.initials: S
authors.lastname: Mitani
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Fujita
authors.forename: Masako
authors.initials: M
authors.lastname: Shigeta
authors.forename: Nagato
authors.initials: N
authors.lastname: Kuriyama
authors.forename: Etsuko
authors.initials: E
authors.lastname: Ozaki
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsui
authors.forename: Isao
authors.initials: I
authors.lastname: Watanabe
authors.forename: Kaoru
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000842:Ankle / Q000098:blood supply* / Q000503:physiopathology; D062186:Arterial Pressure; D044466:Asian People; D050197:Atherosclerosis / Q000175:diagnosis; D001916:Brachial Artery / Q000503:physiopathology*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000295:instrumentation* / Q000379:methods; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology