title: Cationic thermosensitive liposomes: a novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells.
abstract: Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor.
authors.affiliation: Laboratory Experimental Surgical Oncology, Section Surgical Oncology, Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Bilyana M
authors.initials: BM
authors.lastname: Dicheva
authors.forename: Timo L M
authors.initials: TL
authors.lastname: ten Hagen
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Debby
authors.initials: D
authors.lastname: Schipper
authors.forename: Ann L B
authors.initials: AL
authors.lastname: Seynhaeve
authors.forename: Gerard C
authors.initials: GC
authors.lastname: van Rhoon
authors.forename: Alexander M M
authors.initials: AM
authors.lastname: Eggermont
authors.forename: Lars H
authors.initials: LH
authors.lastname: Lindner
authors.forename: Gerben A
authors.initials: GA
authors.lastname: Koning
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002412:Cations; D016503:Drug Delivery Systems; D004730:Endothelium, Vascular / Q000187:drug effects*; D006358:Hot Temperature; D008081:Liposomes; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002412:Cations; D008081:Liposomes