title: Immunogenicity and safety of measles-mumps-rubella and varicella vaccines coadministered with a fourth dose of Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine in toddlers: a pooled analysis of randomized trials.
abstract: A pooled analysis was conducted of 1257 toddlers who received a fourth dose of Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783). Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.
authors.affiliation: University of Louisville, Louisville, KT USA. k0brya01@louisville.edu
authors.forename: Kristina
authors.initials: K
authors.lastname: Bryant
authors.forename: Jodie
authors.initials: J
authors.lastname: McVernon
authors.forename: Colin
authors.initials: C
authors.lastname: Marchant
authors.forename: Terry
authors.initials: T
authors.lastname: Nolan
authors.forename: Gary
authors.initials: G
authors.lastname: Marshall
authors.forename: Peter
authors.initials: P
authors.lastname: Richmond
authors.forename: Helen
authors.initials: H
authors.lastname: Marshall
authors.forename: Michael
authors.initials: M
authors.lastname: Nissen
authors.forename: Stephen
authors.initials: S
authors.lastname: Lambert
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Aris
authors.forename: Narcisa
authors.initials: N
authors.lastname: Mesaros
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Miller
mesh_terms: D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D016032:Randomized Controlled Trials as Topic; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D019433:Chickenpox Vaccine; D018073:Haemophilus Vaccines; C527605:Hib-MenCY-TT vaccine; D022542:Measles-Mumps-Rubella Vaccine; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate