title: Mannose receptor may be involved in small ruminant lentivirus pathogenesis.
abstract: Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.
authors.affiliation: Institute of Agrobiotechnology, CSIC-UPNA-Government of Navarra, Ctra Mutilva, Mutilva Baja, 31192, Spain. ramses.reina@unavarra.es.
authors.forename: Helena
authors.initials: H
authors.lastname: Crespo
authors.forename: Paula
authors.initials: P
authors.lastname: Jauregui
authors.forename: Idoia
authors.initials: I
authors.lastname: Glaria
authors.forename: Leticia
authors.initials: L
authors.lastname: Sanjosé
authors.forename: Laura
authors.initials: L
authors.lastname: Polledo
authors.forename: Juan F
authors.initials: JF
authors.lastname: García-Marín
authors.forename: Lluís
authors.initials: L
authors.lastname: Luján
authors.forename: Damián
authors.initials: D
authors.lastname: de Andrés
authors.forename: Beatriz
authors.initials: B
authors.lastname: Amorena
authors.forename: Ramsés
authors.initials: R
authors.lastname: Reina
mesh_terms: D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000662:veterinary / Q000821:virology; D004660:Encephalitis / Q000235:genetics / Q000662:veterinary / Q000821:virology; D005260:Female; D005786:Gene Expression Regulation; D037181:Lectins, C-Type / Q000235:genetics* / Q000378:metabolism; D016180:Lentivirus Infections / Q000235:genetics / Q000662:veterinary* / Q000821:virology; D017972:Lentiviruses, Ovine-Caprine / Q000302:isolation & purification*; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000235:genetics* / Q000378:metabolism; D009928:Organ Specificity; D011014:Pneumonia / Q000235:genetics / Q000662:veterinary / Q000821:virology; D011533:Proviruses / Q000302:isolation & purification*; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics* / Q000821:virology; D013030:Spain; D019562:Viral Load / Q000662:veterinary*
chemical_list: D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface