title: Crosstalk between TGF-β signaling and the microRNA machinery.
abstract: The activin/transforming growth factor-β (TGF-β) pathway plays an important role in tumorigenesis either by its tumor suppressor or tumor promoting effect. Loss of members of the TGF-β signaling by somatic mutations or epigenetic events, such as DNA methylation or regulation by microRNA (miRNA), may affect the signaling process. Most members of the TGF-β pathway are known to be targeted by one or more miRNAs. In addition, the biogenesis of miRNAs is also regulated by TGF-β both directly and through SMADs. Based on these interactions, it appears that autoregulatory feedback loops between TGF-β and miRNAs influence the fate of tumor cells. Our aim is to review the crosstalk between TGF-β signaling and the miRNA machinery to highlight potential novel therapeutic targets.
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Henriett
authors.initials: H
authors.lastname: Butz
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
authors.forename: László
authors.initials: L
authors.lastname: Hunyady
authors.forename: Attila
authors.initials: A
authors.lastname: Patócs
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002478:Cells, Cultured; D044127:Epigenesis, Genetic; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009154:Mutation; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D051785:Smad Proteins; D016212:Transforming Growth Factor beta