title: Clinical, histopathological and mineralogical analysis findings of an unusual case of pneumoconiosis.
abstract: A 43-year-old man with a long history of dyspnea which had progressively     worsened over the preceding month is presented. He had worked in an antimony     mine for 3 years. Radiologically, there were diffuse reticulonodular shadowing     opacities in both lung parenchymas. Histopathologic examination of the open-lung     biopsy specimen revealed alveolar spaces filled with dust-laden macrophages and     amorphous proteinaceous semifluid, the latter being immunoreactive for Human     Surfactant Apoprotein A, associated with marked interstitial accumulation of the     similar-looking macrophages along the bronchovascular bundles and mild     interstitial fibrosis. Silicotic nodules or mixed dust fibrosis were not seen.     The patient was diagnosed as silicoproteinosis with unusual histopathological     features because he had worked in an antimony mine for only 3 years and had 86%     silica in a mineralogical analysis. Pneumoconiosis is a rare lung disease which     may be confused with other interstitial lung diseases. Clinical, radiological     and unusual histopathologic features of this rare case are presented and     discussed with the differential diagnosis, especially of mixed dust     pneumoconiosis.
authors.affiliation: Department of Pathology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, Turkey. mehmetkefeli@gmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kefelı
authors.forename: Ilkser
authors.initials: I
authors.lastname: Akpolat
authors.forename: Handan
authors.initials: H
authors.lastname: Zeren
authors.forename: Atilla Güven
authors.initials: AG
authors.lastname: Atici
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumortier
authors.forename: Koichi
authors.initials: K
authors.lastname: Honma
authors.forename: Bilge
authors.initials: B
authors.lastname: Can
mesh_terms: D000328:Adult; D000965:Antimony; D001706:Biopsy; D003937:Diagnosis, Differential; D004391:Dust; D004417:Dyspnea / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D008297:Male; D008906:Mining; D016273:Occupational Exposure; D011237:Predictive Value of Tests; D011239:Prednisolone / Q000627:therapeutic use; D012829:Silicosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004391:Dust; D005938:Glucocorticoids; D000965:Antimony; D011239:Prednisolone