title: Expression of survivin and VEGF-C in breast cancer tissue and its relation to lymphatic metastasis.
abstract: OBJECTIVE
  To study the expression of survivin and VEGF-C in breast cancer tissue and its relation to lymphatic metastasis.
  
  
  METHODS
  The expression level of survivin and VEGF-C in breast cancer tissue is determined by immunohistochemistry and reverse transcriptase polymerase chain reaction (Rt-PCR).
  
  
  RESULTS
  Among the 60 breast cancer tissues, the percentage of positive expression of survivin or VEGF-C was 85.0% and 78.3%, respectively. The expression rate of VEGF-C was 84.3% (43/51), 44.4% (4/9) in the survivin positive and negative expression group, respectively. Linear correlation analysis showed a correlation coefficient of survivin and VEGF-C in breast cancer was 0.80 (p = 0.035), which indicates a positive correlation between the two biomarkers.
  
  
  CONCLUSIONS
  Survivin and VEGF-C are highly expressed in breast cancer tissues with a positive correlation. The regulation of survivin expression can cause excessive expression of VEGF-C, leading to the generation of breast cancer lymphangiogenesis, thus causing lymphatic metastasis of breast cancer.
authors.affiliation: Department of General Surgery, Affiliated Hospital of Taishan Medical College, Taian, China. drlixqi@hotmail.com
authors.forename: Xiangqi
authors.initials: X
authors.lastname: Li
authors.forename: Xianigguo
authors.initials: X
authors.lastname: Dang
authors.forename: Xibo
authors.initials: X
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology; D018276:Carcinoma, Medullary / Q000378:metabolism* / Q000473:pathology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D018709:Statistics, Nonparametric; D000077022:Survivin; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D012333:RNA, Messenger; D000077022:Survivin; D042582:Vascular Endothelial Growth Factor C