title: Antipyretic and anticonvulsant activity of Polygonatum verticillatum: comparison of rhizomes and aerial parts.
abstract: The current study was undertaken to explore the antipyretic and anticonvulsant profile of the Polygonatum verticillatum in established pharmacological paradigms. The crude methanol extract of rhizomes (PR) and aerial parts (PA) of the plant were tested in Brewer's-yeast-induced pyrexia and pentylenetetrazole-induced convulsion test. PR and PA both evoked prominent antipyretic activity (p < 0.01) in a dose-dependent manner during all assessment times at the dose of 50, 100, and 200 mg/kg intraperitoneally. The protection elicited by PR (82.20%) at 200 mg/kg was comparable with aspirin (88.48%) as a standard drug at 100 mg/kg. However, PA was less potent, and maximum protection was 64% at 200 mg/kg. Both PR and PA were devoid of any anticonvulsant activity. Our results demonstrated prominent evidence of antipyretic activity of P. verticillatum that is consistent with the folk uses of the plant. In addition from a biodiversity point of view, PA of the plant can also be used as an alternate of PR.
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan. hkdr2006@gmail.com
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saeed
authors.forename: Anwarul Hassan
authors.initials: AH
authors.lastname: Gilani
authors.forename: Naveed
authors.initials: N
authors.lastname: Muhammad
authors.forename: Ikram-Ul
authors.initials: IU
authors.lastname: Haq
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ashraf
authors.forename: Najeeb-Ur
authors.initials: NU
authors.lastname: Rehman
authors.forename: Ashhad
authors.initials: A
authors.lastname: Haleemi
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D031384:Polygonatum / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants; D058633:Antipyretics; D010936:Plant Extracts