title: Hypokalemic periodic paralysis due to proximal renal tubular acidosis in a case with membranoproliferative glomerulonephritis.
abstract: Proximal renal tubular acidosis (pRTA) is a rare disorder. Hypokalemia may be associated with it; occasionally leading to features like hypokalemic periodic paralysis. Though pRTA is a tubulointerstitial kidney disease, glomerulonephritis may occasionally lead to pRTA by tubular damage through leaking proteins, cytokines or by inflammatory infiltrates. In our reported case a 27 year old male had recurrent episodes of hypokalemic quadriparesis. Investigations revealed features of pRTA including hypokalemia and non-anion-gap hyperchloremic metabolic acidosis. His urine pH dropped to 5 with NH4Cl loading test. Kidney biopsy showed membranoproliferative glomerulonephritis with tubulointerstitial damage. Hypokalemic periodic paralysis and pRTA are uncommon associations of membranoproliferative glomerulonephritis.
authors.affiliation: Dept. of Medicine, Medical College, 88, College Street, Kolkata--700073.
authors.forename: Gouranga
authors.initials: G
authors.lastname: Santra
authors.forename: Dibyendu
authors.initials: D
authors.lastname: De
authors.forename: Pradip Kumar
authors.initials: PK
authors.lastname: Sinha
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000473:pathology; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000473:pathology*; D006801:Humans; D020514:Hypokalemic Periodic Paralysis / Q000209:etiology*; D008297:Male; D011782:Quadriplegia / Q000209:etiology