title: Spontaneously occurring multicentric basal cell carcinoma and keratoacanthomas in a multimammate mouse (Mastomys spp.).
abstract: A multicentric basal cell carcinoma was diagnosed in a male multimammate mouse (Mastomys spp.) with widespread cutaneous alterations. Macroscopically, the skin was thickened and extremely wrinkled. Histopathological examination showed multicentric expanding cell-rich tumors composed of basaloid cells interpreted as basal cell carcinoma. Immunohistochemistry detected strong cytokeratin 14 positivity in the epidermal basal layer and in loosely arranged areas of these tumors but only a minimal positive reaction in densely packed areas of tumor cells. Furthermore, samples from the abdomen showed 3 nodular proliferations diagnosed as keratoacanthomas.
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany. Maja.Eydner@tiho-hannover.de
authors.forename: Maja
authors.initials: M
authors.lastname: Eydner
authors.forename: Björn
authors.initials: B
authors.lastname: Jacobsen
authors.forename: Martina
authors.initials: M
authors.lastname: Thomann
authors.forename: Susanne
authors.initials: S
authors.lastname: Rittinghausen
authors.forename: Michael
authors.initials: M
authors.lastname: Fehr
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumgärtner
mesh_terms: D000818:Animals; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D007636:Keratoacanthoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D051189:Murinae; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*