title: Treatment of hypergranulation tissue with high potency topical corticosteroids in children.
abstract: Hypergranulation is having more granulation tissue than needed to fill a wound defect. Some pediatric dermatologists and most dermatologic surgeons will encounter this complication during their careers. Associated factors include wound site, prolonged inflammation, an imbalance in matrix metalloproteinases, and excessive angiogenesis. Reported treatments have included silver nitrate, excision, laser ablation, and topical corticosteroids. Our case series supports the use of medium- to high-potency topical corticosteroids in the treatment of hypergranulation tissue.
authors.affiliation: Department of Dermatology, Duke University Medical Center, Durham, North Carolina 27713, USA.
authors.forename: Diana B
authors.initials: DB
authors.lastname: McShane
authors.forename: Jane S
authors.initials: JS
authors.lastname: Bellet
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006097:Granulation Tissue / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones