title: Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  Obesity-associated nonalcoholic fatty liver disease (NAFLD) is highly prevalent, for which weight loss is the generally recommended clinical management. Low-carbohydrate ketogenic diets have been successful in promoting weight loss, but variations in the range of metabolic responses to these diets indicate that the effects of altering macronutrient content are not completely understood. This review focuses on the most recent findings that reveal the relationship between low-carbohydrate diets and NAFLD in rodent models and humans.
  
  
  RESULTS
  Low-carbohydrate diets have been shown to promote weight loss, decrease intrahepatic triglyceride content, and improve metabolic parameters of patients with obesity. These ketogenic diets also provoke weight loss in rodents. However, long-term maintenance on a ketogenic diet stimulates the development of NAFLD and systemic glucose intolerance in mice. The relationship between ketogenic diets and systemic insulin resistance in both humans and rodents remains to be elucidated.
  
  
  CONCLUSIONS
  Because low-carbohydrate ketogenic diets are increasingly employed for treatment of obesity, NAFLD, and neurological diseases such as epilepsy, understanding the long-term systemic effects of low-carbohydrate diets is crucial to the development of efficacious and safe dietary interventions.
authors.affiliation: Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Schugar
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crawford
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D050528:Diet, Carbohydrate-Restricted; D055423:Diet, Ketogenic; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism; D018149:Glucose Intolerance / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008099:Liver / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D014280:Triglycerides