title: Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism.
abstract: The combinatory effect of polymorphisms in serotonin transporter and monoamine oxidase-A genes on the aetiopathogenesis of alcoholism was investigated in a sample of 714 individuals. Increased frequency of subjects having three 'suspected' genotypes (5-HTTLPR-LL, STin2-1010 and MAO-A 3-repeat allele) was found among type-2 alcoholic patients (P=0.0189). Results highlight serotonergic/genetic contribution to early-onset alcoholism.
authors.affiliation: Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Bordukalo-Niksic
authors.forename: Jasminka
authors.initials: J
authors.lastname: Stefulj
authors.forename: Ana
authors.initials: A
authors.lastname: Matosic
authors.forename: Gordana
authors.initials: G
authors.lastname: Mokrovic
authors.forename: Lipa
authors.initials: L
authors.lastname: Cicin-Sain
mesh_terms: D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase