title: NF-κB in cancer: a matter of life and death.
abstract: Activation of NF-κB has been linked to various cellular processes in cancer, including inflammation, transformation, proliferation, angiogenesis, invasion, metastasis, chemoresistance, and radioresistance. Although acute inflammation mediates innate and humoral immunity, chronic inflammation has been linked to tumorigenesis. Thus, inhibition of NF-κB has therapeutic potential in sensitization of tumors to chemotherapeutic agents; however, generalized suppression of NF-κB can result in serious host toxicity with minimum effect on the tumor.
authors.affiliation: Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. aggarwal@mdanderson.org
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
authors.forename: Bokyung
authors.initials: B
authors.lastname: Sung
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D016328:NF-kappa B