title: Medulloblastoma in a child with fragile X syndrome.
abstract: Fragile X syndrome is the most common cause of inherited intellectual impairment and has been associated with decreased incidence of cancer. We present the case of an 11-year-old boy with a diagnosis of fragile X syndrome who presented with gait imbalance, headache, and episodes of vomiting. Radiological investigation revealed the presence of a posterior fossa tumor. The patient was operated upon and the tumor proved to be a medulloblastoma (MB). To the best of our knowledge this is the first reported case of MB in a child with fragile X syndrome.
authors.affiliation: Department of Neurosurgery, Children's Hospital Agia Sofia, Athens, Greece. alexiougrg@yahoo.gr
authors.forename: George A
authors.initials: GA
authors.lastname: Alexiou
authors.forename: George
authors.initials: G
authors.lastname: Siozos
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Stefanaki
authors.forename: Eustathios
authors.initials: E
authors.lastname: Vlachakis
authors.forename: George
authors.initials: G
authors.lastname: Sfakianos
authors.forename: Neofytos
authors.initials: N
authors.lastname: Prodromou
authors.forename: Maria
authors.initials: M
authors.lastname: Moschovi
mesh_terms: D002648:Child; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D015192:Infratentorial Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome