title: Functional outcome of limb salvage surgery with mega-endoprosthetic reconstruction for bone tumors.
abstract: BACKGROUND
  The use of a mega-endoprosthesis has become the method of choice for reconstruction after bone tumors. In this study, we sought to determine the functional outcome and complications associated with mega-endoprosthesis.
  
  
  METHODS
  A retrospective review of the charts of 16 patients who had undergone resection of bone tumors followed by reconstruction with mega-endoprosthesis between 2006 and 2011 was performed. Functional evaluation was based on the Musculoskeletal Tumor Society (MSTS) scoring system. Complications of the procedures were also analyzed.
  
  
  RESULTS
  Eight men and eight women at an average age of 36.7 years were included in the study. The tumor involved lower limb in 14 patients and upper limb in 2 patients. The average MSTS functional score was 72.3 ± 15. Excellent results were achieved in six patients, good in five, moderate and fair in two each and poor in one. Complications occurred in eight patients. Two patients had aseptic loosening of the femoral component of total knee replacement. Flap necrosis occurred in two patients, both of whom required latissimus dorsi free flap for coverage of total knee prosthesis. One patient underwent revision of femoral component subsequent to knee dissociation. Local recurrence of tumor, patellar tendon rupture and foot drop occurred in one patient each.
  
  
  CONCLUSIONS
  Mega-endoprosthetic reconstruction in limb salvage provides good functional outcome in patients with bone tumors.
authors.affiliation: Department of Surgery, Aga Khan University Hospital, Room 211, Male Hostel, Karachi, 74800, Pakistan. muhamad_irfan_qadir@yahoo.com
authors.forename: Irfan
authors.initials: I
authors.lastname: Qadir
authors.forename: Masood
authors.initials: M
authors.lastname: Umer
authors.forename: Naveed
authors.initials: N
authors.lastname: Baloch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D019919:Prosthesis Implantation; D020127:Recovery of Function; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult