title: Antinociceptive effects of galanin in the nucleus accumbens of rats.
abstract: It has been demonstrated that galanin plays important roles in the modulation of nociceptive information in rats. The present study is performed to investigate the regulating role of galanin in nociception in the nucleus accumbens (NAc) of rats. Intra-NAc administration of galanin induces dose-dependent increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. Furthermore, the galanin-induced antinociceptive effects are blocked by following intra-NAc injection of the galanin receptor antagonist galantide. The results demonstrate that galanin induces antinociceptive effects in the NAc of rats, and galanin receptors are involved in the galanin-induced antinociception effects.
authors.affiliation: Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Shi-Lian
authors.initials: SL
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Long-Chuan
authors.initials: LC
authors.lastname: Yu
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D019004:Galanin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D006358:Hot Temperature; D007276:Injections, Intraventricular; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000503:physiopathology*; D010146:Pain / Q000378:metabolism / Q000503:physiopathology*; D010147:Pain Measurement; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D044088:Receptors, Galanin / Q000037:antagonists & inhibitors; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000700:Analgesics; D044088:Receptors, Galanin; C074975:galantide; D013373:Substance P; D019004:Galanin