title: Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: the multi-ethnic study of atherosclerosis.
abstract: OBJECTIVE
  We previously reported a statistically significant association of SCARB1 intronic single nucleotide polymorphism (SNP) rs10846744 with common carotid intimal-medial artery thickness in each of the 4 Multi-Ethnic Study of Atherosclerosis racial/ethnic groups (white, Chinese, black, and Hispanic).
  
  
  RESULTS
  Using an expanded sample of 7936 Multi-Ethnic Study of Atherosclerosis participants, phenotyped for measures of subclinical atherosclerosis, incident myocardial infarction, and cardiovascular disease, and genotyped through the SNP Health Association Resource project, we have now examined the genetic association of these phenotypes with 126 genotyped and imputed SCARB1 SNPs. We also performed stratified analyses to examine whether SCARB1 SNP effects differed by sex. Our analysis of the full Multi-Ethnic Study of Atherosclerosis cohort provides strong evidence for the association of rs10846744 with common carotid intimal-medial thickness (P=1.04E-4 in combined analysis of all 4 Multi-Ethnic Study of Atherosclerosis racial/ethnic groups). In sex-stratified analysis, we observed statistically significant association of rs10846744 with incident cardiovascular disease events in males (P=0.01). Examining analytical results from the Myocardial Infarction Genetics Consortium for replication, we observed further support for the association of rs10846744 with myocardial infarction.
  
  
  CONCLUSIONS
  The SCARB1 SNP, rs10846744, exerts a major effect on subclinical atherosclerosis and incident cardiovascular disease in humans.
authors.affiliation: Center for Public Health Genomics and Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Ani
authors.initials: A
authors.lastname: Manichaikul
authors.forename: Adam C
authors.initials: AC
authors.lastname: Naj
authors.forename: David
authors.initials: D
authors.lastname: Herrington
authors.forename: Wendy
authors.initials: W
authors.lastname: Post
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.forename: Annabelle
authors.initials: A
authors.lastname: Rodriguez
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000208:ethnology / Q000235:genetics*; D044383:Black People; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics*; D059168:Carotid Intima-Media Thickness; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D051122:Scavenger Receptors, Class B / Q000235:genetics*; D044465:White People
chemical_list: C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B