title: Effect of endoscopic sinus surgery on plasma asymmetric dimethylarginine levels in patients with extensive nasal polyposis.
abstract: OBJECTIVE
  This study examined the effect of endoscopic sinus surgery (ESS) on plasma levels of asymmetric dimethylarginine (ADMA) and mean pulmonary arterial pressure (mPAP) in patients with extensive nasal polyposis (ENP).
  
  
  METHODS
  Preoperative and 3 month post-ESS plasma levels of ADMA and mPAP were measured in patients with ENP and in age-and gender-matched controls.
  
  
  RESULTS
  The study included 45 patients with ENP and 31 controls (mean ± SD age 39.4 ± 8.8 and 38.1 ± 9.6 years, respectively). The mean preoperative ADMA level in ENP patients (0.69 ± 0.27 μmol/l) was statistically significantly lower than in the control group (1.08 ± 0.37 μmol/l). The postoperative ADMA level increased significantly in ENP patients (0.97 ± 0.36 μmol/l) versus the preoperative level. Mean preoperative mPAP in ENP patients (25.7 ± 5.4 mmHg) was statistically significantly higher than in the control group (20.8 ± 2.1 mmHg), and ENP patients showed significant decreases in mPAP after (21.9 ± 3.5 mmHg) versus before ESS.
  
  
  CONCLUSIONS
  Patients with ENP had lower plasma ADMA levels compared with healthy controls, however ADMA levels and mPAP improved in ENP patients after ESS.
authors.affiliation: Ear, Nose and Throat Department, Erzurum Education and Research Hospital, Erzurum, Turkey. vuralf@mynet.com
authors.forename: V
authors.initials: V
authors.lastname: Fidan
authors.forename: H
authors.initials: H
authors.lastname: Alp
authors.forename: F
authors.initials: F
authors.lastname: Karaca
authors.forename: Ad
authors.initials: A
authors.lastname: Ozcan
authors.forename: K
authors.initials: K
authors.lastname: Ozcan
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001794:Blood Pressure; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000097:blood / Q000601:surgery*; D010256:Paranasal Sinuses / Q000473:pathology / Q000601:surgery*; D011651:Pulmonary Artery
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine