title: Inherited thrombophilia and IVF failure: the impact of coagulation disorders on implantation process.
abstract: In connection with the embryo acceptance process after IVF procedure, endometrial cells surface receptors, extracellular matrix (ECM) molecules, endothelium and blood circulation factors were involved in remodelling of endometrium. Plasminogen activator inhibitor type 1 plays a significant role during the early phases of placental vascular remodelling and regulates the trophoblast invasion through controlling plasmin activity. Endometrial cell surface protein integrin alphaV/beta3, responsible for the adhesion of the embryo, has had also the same subunit beta3, which is component of integrin alphaIIb/beta3 connected with platelet aggregability. Prothrombin, furthermore, has had a debatable effect upon endothelial and mesenchymal cells and possible contribution on embryo vascular development. Confoundable data have been present about the role of coagulation factor V and its role for implantation. These and other coagulation factors have relatively common gene polymorphisms that enhanced their activity. This review discusses the effect of increased coagulation activity on implantation process, which is not yet fully determined. The establishment of the positive or negative impact of mother hypercoagulability on the success of embryo implantation after assisted reproduction technology could determine the timing of preventing anticoagulant therapy in women with history of early embryo loss.
authors.affiliation: Clinical Institute for Reproductive Medicine, Pleven, Bulgaria. mdivanov@gmail.com
authors.forename: Petar
authors.initials: P
authors.lastname: Ivanov
authors.forename: Tsvetomira
authors.initials: T
authors.lastname: Tsvyatkovska
authors.forename: Emiliana
authors.initials: E
authors.lastname: Konova
authors.forename: Regina
authors.initials: R
authors.lastname: Komsa-Penkova
mesh_terms: D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D005165:Factor V / Q000378:metabolism*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000097:blood* / Q000150:complications; D039302:Integrin alphaVbeta3 / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D040201:Platelet Membrane Glycoprotein IIb / Q000097:blood; D011516:Prothrombin / Q000378:metabolism; D019851:Thrombophilia / Q000097:blood* / Q000150:complications; D017211:Treatment Failure; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D039302:Integrin alphaVbeta3; D017395:Plasminogen Activator Inhibitor 1; D040201:Platelet Membrane Glycoprotein IIb; D005165:Factor V; D011516:Prothrombin