title: Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial.
abstract: Dyslipidemia is a leading risk factor for cardiovascular disease and is also a common feature of obesity. Curcumin is a bioactive phytochemical with well-known antioxidant, anti-inflammatory, and cardioprotective properties. The present study investigated the hypolipidemic activity of curcumin in obese individuals. Participants (n = 30) were treated with curcuminoids (1 g/day), or placebo in a randomized, double-blind, placebo-controlled, crossover trial. Serum concentrations of total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, together with anthropometric parameters and high-sensitivity C-reactive protein were measured before and after each treatment period. Anthropometric parameters including weight, BMI, waist circumference, hip circumference, arm circumference, and body fat remained statistically unchanged by the end of trial (p > 0.05). As for the lipid profile parameters, serum triglycerides were significantly reduced following curcumin supplementation (p = 0.009). However, curcuminoids were not found to affect serum levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein (p > 0.05). In summary, the findings of the present study indicated that curcuminoid supplementation (1 g/day for 30 days) leads to a significant reduction in serum triglycerides concentrations but do not have a significant influence on other lipid profile parameters as well as body mass index and body fat.
authors.affiliation: Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Mohammadi
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Sahebkar
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
authors.forename: Maral
authors.initials: M
authors.lastname: Amini
authors.forename: Roshanak
authors.initials: R
authors.lastname: Khojasteh
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D003474:Curcumin / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D050171:Dyslipidemias / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D003474:Curcumin