title: [Long term epidemiological effects of vaccination on hemorrhagical fever with renal syndrome (HFRS) in Shaanxi provincial HFRS epidemic areas].
abstract: OBJECTIVE
  To evaluate the protective rate and the variation of HFRS-IgG on hemorrhagical fever with renal syndrome (HFRS) vaccine.
  
  
  METHODS
  Cluster, random sampling and cross-sectional study were used to assess the protective rate of HFRS vaccination. Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS.
  
  
  RESULTS
  Curve equation was obtained as Yprotective rate=(0.863+0.283/Xvaccination term)×100% by protective rate with vaccination term. Protective rates showed a reducing trend, 90% after 7-8 years of vaccination, 88% after 10 years, and 94% on average. Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without, in the epidemic area. Higher antibody level could be obtained after primary vaccination, but the level of antibody had a 50% reduction after 5-10 years of vaccination, and a 60% reduction after 10 years of vaccination.
  
  
  CONCLUSIONS
  HFRS antibody had a 50% reduction after 5-10 years of vaccination. The protective rate of HFRS vaccination had a 90% loss, after 7-8 years of vaccination. Booster dose was necessary after 7 years of vaccination.
authors.affiliation: Shaanxi Provincial Centre for Disease Control and Prevention, Xi'an 710054, China. jingjunwang@china.com
authors.forename: Jing-jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Zhan-zhen
authors.initials: ZZ
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.forename: Chang-an
authors.initials: CA
authors.lastname: Ma
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Dong
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Lu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Peng-bo
authors.initials: PB
authors.lastname: Yu
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Qu
authors.forename: Li-fang
authors.initials: LF
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D018063:Hantaan virus / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012494:Sampling Studies; D014765:Viral Vaccines / Q000276:immunology*; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014765:Viral Vaccines