title: Expanding the horizons of lipidomics. Towards fluxolipidomics.
abstract: This short review takes into consideration the status of lipidomics as issued from almost a decade of development. Because of the huge number of molecular species analyzed, there is a trend in subdividing lipidomics according to subdomains, in particular relating to the function of molecules. It is also pointed out that lipid imaging without the use of exogenous probes will help making relationships between molecular structures and the topography of lipid assemblies, especially in cellular compartments. Finally, a fluxomics approach is proposed for lipid molecular species, both in terms of compartments and biochemical metabolism. The example of fluxolipidomics of essential fatty acids toward their enzyme-dependent oxygenated metabolites and further toward their degradation products is developed.
authors.affiliation: UMR 1060 INSERM-CarMeN, IMBL, INSA-Lyon, Villeurbanne 60621, France. Michel.Lagarde@insa-lyon.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Lagarde
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bernoud-Hubac
authors.forename: Michel
authors.initials: M
authors.lastname: Guichardant
mesh_terms: D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D055432:Metabolomics / Q000379:methods* / Q000639:trends