title: Revisiting autologous platelets as an adjuvant in macular hole repair: chronic macular holes without prone positioning.
abstract: OBJECTIVE
  Chronic macular hole and inability to maintain prone positioning remain poor prognostic markers for successful macular hole closure. The authors revisited the role of autologous platelets as an adjunct to internal limiting membrane (ILM) peeling of chronic macular holes in patients unable to maintain prone positioning.
  
  
  METHODS
  A retrospective case study was conducted on 13 eyes of 13 patients with full-thickness chronic macular hole (> 24 months). Each patient was unable to maintain prone positioning due to medical and physical comorbidities. Each eye was treated with pars plana vitrectomy, ILM peeling, autologous platelets, and C(3)F(8) gas tamponade. No positioning was advised postoperatively. All patients had complete ophthalmic examinations preoperatively and 1 day and 1, 3, and 6 months postoperatively with optical coherence tomography. Outcome measures were anatomic closure based on Tornambe classification, final best-corrected visual acuity, and improvement of quality of vision.
  
  
  RESULTS
  All 13 patients completed 6 months' follow-up. Macular hole duration ranged from 2 to 5 years. There was a 100% macular hole closure rate at 1 and 6 months postoperatively. All patients reported subjective improvement in visual acuity as an improvement of an absolute central scotoma. At 6 months postoperatively, 38% of patients reported improved best-corrected visual acuity. There were no recurrences.
  
  
  CONCLUSIONS
  Autologous platelets and ILM peeling may function synergistically to enhance chronic macular hole closure in patients unable to maintain prone positioning.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555, USA. Kaps2003@gmail.com
authors.forename: Kapil G
authors.initials: KG
authors.lastname: Kapoor
authors.forename: Adeel N
authors.initials: AN
authors.lastname: Khan
authors.forename: Brian C
authors.initials: BC
authors.lastname: Tieu
authors.forename: Gibran S
authors.initials: GS
authors.lastname: Khurshid
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000601:surgery*; D001792:Blood Platelets; D002908:Chronic Disease; D003131:Combined Modality Therapy; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016684:Prone Position; D012167:Retinal Perforations / Q000175:diagnosis / Q000601:surgery*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D005466:Fluorocarbons; C042852:perflutren