title: The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.
abstract: Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes (P = 0.004, OR = 1.48, 95% CI = 1.13-1.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age.
authors.affiliation: Beijing Anding Hospital, Capital Medical University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Pei
authors.forename: Alicia K
authors.initials: AK
authors.lastname: Smith
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Pan
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Weigang
authors.initials: W
authors.lastname: Pan
authors.forename: Feng
authors.initials: F
authors.lastname: Bao
authors.forename: Lisha
authors.initials: L
authors.lastname: Zhao
authors.forename: Changle
authors.initials: C
authors.lastname: Tie
authors.forename: Yizheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Zhen
authors.forename: Jinxia
authors.initials: J
authors.lastname: Zhou
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: D019208:Brain-Derived Neurotrophic Factor