title: Oxidised LDL/LDL-cholesterol ratio and coronary artery calcification in haemodialysis patients.
abstract: OBJECTIVE
  Serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) and MDA-LDL/LDL-cholesterol (LDL-c) ratio are risk factors for arteriosclerosis and cardiovascular disease (CVD). However, no information is available on these parameters or their associations with coronary artery calcification (CAC) in haemodialysis (HD) patients.
  
  
  RESULTS
  Fifty-seven HD patients and 26 control subjects were included in this cross-sectional study. Serum MDA-LDL concentrations and MDA-LDL/LDL-c ratios were examined. HD patients had significantly higher MDA-LDL/LDL-c ratios than the controls (105.1 ± 27.5 vs. 81.4 ± 18.9 mU/mg, P < 0.001); however, there was no significant difference in serum MDA-LDL levels between the 2 groups. CAC scores were examined only in HD patients and their possible associations with the clinical/laboratory data were analysed. Analysis of HD patients showed that MDA-LDL/LDL-c ratio has an association with presence of CVD, CAC score, HD duration, MDA-LDL, or haemoglobin A1C. In addition, the CAC score was positively correlated with serum MDA-LDL level (P = 0.048) and MDA-LDL/LDL-c ratio (P = 0.006). Furthermore, multivariate logistic regression analysis showed that MDA-LDL/LDL-c ratio (β = 0.04, P = 0.003) and HD duration (β = 0.16, P = 0.007) were independently associated with CAC score.
  
  
  CONCLUSIONS
  The MDA-LDL/LDL-c ratio of HD patients was significantly higher than that of non-HD subjects and was independently associated with the CAC score. Therefore, this ratio could be an important risk factor for CAC in HD patients.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1, Kawada-chou, Shinjuku-ku, Tokyo 162-8666, Japan. yukari-asamiya@citrus.ocn.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Asamiya
authors.forename: A
authors.initials: A
authors.lastname: Yajima
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuruta
authors.forename: S
authors.initials: S
authors.lastname: Otsubo
authors.forename: K
authors.initials: K
authors.lastname: Nitta
mesh_terms: D000368:Aged; D000465:Algorithms; D008078:Cholesterol, LDL / Q000097:blood* / Q000737:chemistry; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000737:chemistry; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000628:therapy; D012307:Risk Factors; D012720:Severity of Illness Index; D061205:Vascular Calcification / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology
chemical_list: D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde