title: Secondary head and neck cancer in patients with history of hematological malignancy.
abstract: BACKGROUND
  Head and neck cancer is a common second cancer in patients with a history of hematological malignancies. The purpose of this study was present the clinical characteristics and treatment outcomes of this group of patients.
  
  
  METHODS
  A retrospective analysis was conducted of all patients who had a history of hematological malignancy and developed head and neck cancer in a 10-year period.
  
  
  RESULTS
  The cohort had 10 patients; median age was 45.8 years. Most patients were nonsmokers and nondrinkers. Seven patients had chronic graft-versus-host disease. The median interval between the completion of treatment of hematological malignancy and the development of head and neck cancers was 8.79 years (range, 2.33-26.83 years). Six patients were alive and disease-free, 3 developed local recurrence, and 3 had metachronous head and neck cancers.
  
  
  CONCLUSIONS
  The risk factors and etiology of head and neck cancers in patients with hematological malignancy may be different from the ordinary population.
authors.affiliation: Division of Otorhinolaryngology-Head & Neck Surgery, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Regions, People's Republic of China. jckchung@graduate.hku.hk
authors.forename: Joseph Chun-Kit
authors.initials: JC
authors.lastname: Chung
authors.forename: Raymond King-Yin
authors.initials: RK
authors.lastname: Tsang
authors.forename: Victor Shing-Howe
authors.initials: VS
authors.lastname: To
authors.forename: Ambrose Chung-Wai
authors.initials: AC
authors.lastname: Ho
authors.forename: Jimmy Yu-Wai
authors.initials: JY
authors.lastname: Chan
authors.forename: Wai-Kuen
authors.initials: WK
authors.lastname: Ho
authors.forename: William Ignace
authors.initials: WI
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000628:therapy; D019337:Hematologic Neoplasms / Q000601:surgery; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D012189:Retrospective Studies; D012307:Risk Factors; D014062:Tongue Neoplasms; D016896:Treatment Outcome; D055815:Young Adult