title: General and selective head-to-head dimerization of terminal alkynes proceeding via hydropalladation pathway.
abstract: A general highly regio- and stereoselective palladium-catalyzed head-to-head dimerization reaction of terminal acetylenes is presented. This methodology allows for the efficient synthesis of a variety of 1,4-enynes as single E stereoisomers. Computational studies reveal that this dimerization reaction proceeds via the hydropalladation pathway.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Jahier
authors.forename: Olga V
authors.initials: OV
authors.lastname: Zatolochnaya
authors.forename: Nickolay V
authors.initials: NV
authors.lastname: Zvyagintsev
authors.forename: Valentine P
authors.initials: VP
authors.lastname: Ananikov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gevorgyan
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D010165:Palladium