title: R620W functional polymorphism of protein tyrosine phosphatase  non-receptor type 22 is not associated with pulmonary tuberculosis  in Zahedan, southeast Iran.
abstract: The protein tyrosine phosphatase non-receptor type 22  (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is  considered an important regulator of T-cell activation. We investigated a  possible association between the PTPN22 C1858T (R620W) polymorphism and  pulmonary tuberculosis in an Iranian population. Single nucleotide  polymorphisms of PTPN22 C1858T (rs2476601) were genotyped in 172 pulmonary  tuberculosis cases and 204 normal subjects from Zaheden, Iran. Frequencies of  genotypes CC, CT and TT of the PTPN22 C1858T polymorphism were 98.3, 1.7 and 0%  in the pulmonary tuberculosis patients, and 96.1, 3.9 and 0% in the control  group, respectively (P = 0.239). The frequency of the minor (T) allele was 0.8%  in pulmonary tuberculosis patients and 2.0% in controls. Significant  differences were not observed in genotype or allele frequencies of PTPN22  C1858T in the comparison between pulmonary tuberculosis patients and healthy  subjects in our Iranian population sample.
authors.affiliation: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: H-R
authors.initials: HR
authors.lastname: Kouhpayeh
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
authors.forename: S-A
authors.initials: SA
authors.lastname: Hashemi
authors.forename: A
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: M
authors.initials: M
authors.lastname: Naderi
authors.forename: B
authors.initials: B
authors.lastname: Sharifi-Mood
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: M
authors.initials: M
authors.lastname: Mohammadi
authors.forename: S
authors.initials: S
authors.lastname: Ghavami
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000201:enzymology / Q000235:genetics*
chemical_list: D017931:DNA Primers; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22