title: Endothelial cells and thrombotic microangiopathy.
abstract: Thrombotic microangiopathy represents the clinical picture of thrombocytopenia and hemolytic anemia in the setting of small blood vessel thrombosis, accompanied by varying degrees of organ dysfunction. Well known to both nephrologists and hematologists alike, among the most common and best-studied thrombotic microangiopathy are hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura. Despite sharing a strong clinical and historical relationship, these disorders represent distinct clinical and pathophysiological entities. This article reviews recent progress into the pathogenesis of thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, focusing on events taking place at the endothelial surface.
authors.affiliation: Department of Internal Medicine and Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. david-motto@uiowa.edu
authors.forename: David
authors.initials: D
authors.lastname: Motto
mesh_terms: D051722:ADAM Proteins / Q000502:physiology; D000071120:ADAMTS13 Protein; D000818:Animals; D042783:Endothelial Cells / Q000502:physiology*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology; D022621:Shiga Toxin / Q000633:toxicity; D057049:Thrombotic Microangiopathies / Q000209:etiology*; D014841:von Willebrand Factor / Q000502:physiology
chemical_list: D014841:von Willebrand Factor; D022621:Shiga Toxin; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human