title: Protein-templated gold nanoclusters based sensor for off-on detection of ciprofloxacin with a high selectivity.
abstract: In this contribution, bovine serum albumin stabilized gold nanoclusters as novel fluorescent probes were successfully utilized for the detection of ciprofloxacin for the first time. Our prepared gold nanoclusters exhibited strong emission with peak maximum at 635 nm. Cu(2+) was employed to quench the strong fluorescence of the gold nanoclusters, whereas the addition of ciprofloxacin caused the fluorescence intensity restoration of the Cu(2+)-gold nanoclusters system. The increase in fluorescence intensity of Cu(2+)-gold nanoclusters system caused by ciprofloxacin allows the sensitive detection of ciprofloxacin in the range of 0.4 ng mL(-1) to 50 ng mL(-1). The detection limit for ciprofloxacin is 0.3 ng mL(-1) at a signal-to-noise ratio of 3. The present sensor for ciprofloxacin detection possesses a low detection limit and wide linear range. In addition, the real samples were analyzed with satisfactory results.
authors.affiliation: Department of Chemistry, Shantou University, Shantou, 515063, China. kqlu@stu.edu.cn
authors.forename: Zhanguang
authors.initials: Z
authors.lastname: Chen
authors.forename: Sihua
authors.initials: S
authors.lastname: Qian
authors.forename: Junhui
authors.initials: J
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.forename: Shuyan
authors.initials: S
authors.lastname: Wu
authors.forename: Ziping
authors.initials: Z
authors.lastname: Cai
mesh_terms: D000818:Animals; D002417:Cattle; D002939:Ciprofloxacin / Q000097:blood*; D003300:Copper / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D059629:Signal-To-Noise Ratio; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D012710:Serum Albumin, Bovine; D002939:Ciprofloxacin; D006046:Gold; D003300:Copper