title: Structure formation and catalytic activity of DNA dissolved in organic solvents.
abstract: Equal-opportunity dissolver: By attaching polyethylene glycol at its 5' end, DNA (PEG-DNA) can be solubilized in various organic solvents and was shown to form G-quadruplexes by CD spectroscopy. A complex containing iron(III) protoporphyrin IX (hemin) and G-quadruplex-forming PEG-DNA catalyzed an oxidative reaction in methanol (see scheme).
authors.affiliation: Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1, Hirosawa, Wako-Shi, Saitama 351-0198, Japan. h-abe@riken.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.forename: Naoko
authors.initials: N
authors.lastname: Abe
authors.forename: Aya
authors.initials: A
authors.lastname: Shibata
authors.forename: Keiji
authors.initials: K
authors.lastname: Ito
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Mika
authors.initials: M
authors.lastname: Ito
authors.forename: Hisao
authors.initials: H
authors.lastname: Saneyoshi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
mesh_terms: D001483:Base Sequence; D055162:Biocatalysis; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D011092:Polyethylene Glycols / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D012997:Solvents; D011092:Polyethylene Glycols; D004247:DNA