title: Grape seed extract attenuates lung parenchyma pathology in ovalbumin-induced mouse asthma model: an ultrastructural study.
abstract: Due to the growing incidence of asthma and because of the non-specificity and side effects of the conventional drugs, the development of novel agents for the treatment of asthma has become considerably important. Natural plant products offer promising alternatives for the development of effective and safe treatments. Grape seed extract (GSE) is one such phytochemical supplement that has been shown to have potent antioxidant and anti-inflammatory effects. Thus, the present study aimed to investigate the effect of GSE to suppress lung parenchyma pathology and inflammation in ovalbumin-induced murine asthma model. Ovalbumin exposure was associated with many pathological and morphometric alterations in the lungs of asthmatic mice. The alterations involved alveolar size reduction, alveolar wall thickening, cellular infiltration and blood capillary congestion, as well as significant increase in the number of type II pneumocytes and lamellar bodies. However, GSE significantly ameliorated of the pathological changes of ovalbumin-induced asthma. The results support the possibility of GSE as an effective, safe anti-inflammatory dietary supplement to attenuate the pathogenicity of asthma. While these preliminary results appear promising, further studies are required to elucidate the precise mechanism of the modulatory effect of GSE on asthma remodeling.
authors.affiliation: Zoology Department, Faculty of Science, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt. yomna ia@yahoo.com
authors.forename: Yomna Ibrahim
authors.initials: YI
authors.lastname: Mahmoud
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects; D056809:Alveolar Epithelial Cells / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D019587:Dietary Supplements; D056604:Grape Seed Extract / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010047:Ovalbumin; D008517:Phytotherapy; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology; D027843:Vitis / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D056604:Grape Seed Extract; D003907:Dexamethasone; D010047:Ovalbumin