title: Obesity susceptibility loci on body mass index and weight loss in Spanish adolescents after a lifestyle intervention.
abstract: OBJECTIVE
  To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents.
  
  
  METHODS
  Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes.
  
  
  RESULTS
  At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS.
  
  
  CONCLUSIONS
  The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
authors.affiliation: Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
authors.forename: Adriana
authors.initials: A
authors.lastname: Moleres
authors.forename: Tara
authors.initials: T
authors.lastname: Rendo-Urteaga
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Zulet
authors.forename: Ascensión
authors.initials: A
authors.lastname: Marcos
authors.forename: Cristina
authors.initials: C
authors.lastname: Campoy
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Garagorri
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Azcona-Sanjulián
authors.forename: Amelia
authors.initials: A
authors.lastname: Marti
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000293:Adolescent; D015992:Body Mass Index; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008019:Life Style; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D009765:Obesity / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D013030:Spain; D015431:Weight Loss / Q000235:genetics*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015850:Interleukin-6; C470072:MC4R protein, human; D008565:Membrane Proteins; D047495:PPAR gamma; D044105:Receptor, Melanocortin, Type 4; C530715:TMEM18 protein, human