title: Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications.
abstract: A G-quadruplex is a four-stranded DNA structure featuring stacked guanine tetrads, G-quartets. Formation of a G-quadruplex in telomere DNA can inhibit telomerase activity; therefore, development of G-quadruplex-ligands, which induce and/or stabilize G-quadruplexes, has become an area of great interest. Phthalocyanine derivatives have substantial potential as high-affinity G-quadruplex-ligands because these planar chromophores are similar in size and shape to the G-quartets. Here, we focus on the latest findings on phthalocyanine derivatives as G-quadruplex-ligands, and discuss the mechanisms by which phthalocyanines bind to G-quadruplexes with high affinity and selectivity. We also discuss potential biomedical and organic electronic applications of phthalocyanines that are dependent on their photophysical properties.
authors.affiliation: Advanced Technology Research Laboratories, Panasonic Corporation, 3-4 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan.
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Yaku
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Murashima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Miyoshi
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
mesh_terms: D054856:G-Quadruplexes; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008024:Ligands; D015394:Molecular Structure
chemical_list: D007211:Indoles; D054833:Isoindoles; D008024:Ligands; C013647:phthalocyanine