title: Meta genome-wide network from functional linkages of genes in human gut microbial ecosystems.
abstract: The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the basis of a set of functionally coupled genes regardless of their genome origins when considering the co-evolution properties of genes. By analyzing these coupled genes, we showed some basic properties of HGME significantly associated with each other, and further constructed a protein interaction map of human gut meta-genome to discover some functional modules that may relate with essential metabolic processes. Compared with other studies, our method provides a new idea to extract basic function elements from meta-genome systems and investigate complex microbial environment by associating its biological traits with co-evolutionary fingerprints encoded in it.
authors.affiliation: Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ji
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Shi
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.forename: Jianliang
authors.initials: J
authors.lastname: Dai
authors.forename: Yixue
authors.initials: Y
authors.lastname: Li
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000302:isolation & purification; D008040:Genetic Linkage; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D054892:Metagenome / Q000235:genetics*