title: Early versus late amniotomy for labour induction: a randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the impact of early vs. late amniotomy on delivery mode in women undergoing induction of labor.
  
  
  METHODS
  143 women admitted for induction were randomized to early amniotomy (EA, concomitant with the beginning of oxytocin infusion; n = 71) or to late amniotomy (LA, four hours after the beginning of oxytocin; n = 72). Randomization was stratified by parity. The primary outcome was the rate of cesarean. Secondary outcomes were duration of labor and intrapartum fever.
  
  
  RESULTS
  The cesarean rate was similar between groups (18% vs. 17% among nulliparous; and 3% vs. 0% among parous women, in EA and LA group, respectively). However, EA was associated with shorter oxytocin-to-delivery interval (12 vs. 15 h) and a non-significant decrease in intrapartum fever (3% vs. 25%) than LA in nulliparous women (p = 0.05).
  
  
  CONCLUSIONS
  For women undergoing oxytocin induction, early amniotomy is associated with shorter labor in nulliparous women with no effect on the risk of cesarean section in both nulliparous and multiparous women.
authors.affiliation: Department of Obstetrics and Gynecology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Karine
authors.initials: K
authors.lastname: Gagnon-Gervais
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bujold
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Iglesias
authors.forename: Louise
authors.initials: L
authors.lastname: Duperron
authors.forename: André
authors.initials: A
authors.lastname: Masse
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Mayrand
authors.forename: Andrée
authors.initials: A
authors.lastname: Sansregret
authors.forename: William
authors.initials: W
authors.lastname: Fraser
authors.forename: François
authors.initials: F
authors.lastname: Audibert
mesh_terms: D000328:Adult; D000465:Algorithms; D000650:Amnion / Q000601:surgery*; D001724:Birth Weight / Q000502:physiology; D036861:Delivery, Obstetric / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods* / Q000706:statistics & numerical data; D010120:Oxytocics / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage; D010298:Parity / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin