title: Lacosamide in Lennox-Gastaut syndrome: case report.
abstract: BACKGROUND
  Lennox Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by tonic, atonic, and atypical absence seizures usually refractory to pharmacological treatment. Patients generally continue with seizures despite treatment with the commercially available antiepileptic drugs (AEDs). Lacosamide (LCM) is a new AED recently approved for treatment of partial onset seizures with or without secondary generalization. Lacosamide has a novel mechanism of action that seems to be different in relation to other conventional AEDs.
  
  
  OBJECTIVE
  To report LCM-caused worsening of tonic seizures and electroencephalographic pattern in a patient with Lennox-Gastaut syndrome.
  
  
  METHODS
  We report the evolution of a patient with LGS resistant to several AEDs with a cryptogenic hepatopathy in whom LCM caused worsening of tonic seizures and electroencephalographic pattern. Once LCM was discontinued, the patient returned to his clinical and electrical baseline.
  
  
  CONCLUSIONS
  Lennox Gastaut syndrome may exacerbate tonic seizures and electrical pattern of patients with LGS.
authors.affiliation: Epilepsy Section, National Neurology and Neurosurgery Institute, Havana, Cuba. reneandrade1970@yahoo.es
authors.forename: René
authors.initials: R
authors.lastname: Andrade-Machado
authors.forename: Vanessa
authors.initials: V
authors.lastname: Benjumea-Cuartas
authors.forename: Esteban
authors.initials: E
authors.lastname: Jaramillo-Jimenez
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D008607:Intellectual Disability / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D000078334:Lacosamide; D065768:Lennox Gastaut Syndrome; D008297:Male; D013036:Spasms, Infantile / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000081:Acetamides; D000078334:Lacosamide