title: Estradiol increases body weight loss and gut-peptide satiation after Roux-en-Y gastric bypass in ovariectomized rats.
abstract: Despite the fact that ∼85% of bariatric operations are performed in women, the effects of the reproductive axis function on outcome of bariatric surgery remain to be determined. Here we developed the first published model of Roux-en-Y gastric bypass (RYGB) in female rats. We show in ovariectomized rats receiving estradiol or control treatment that (1) RYGB-induced body weight loss and (2) the satiating efficacy of endogenous glucagon-like peptide-1 and cholecystokinin satiation were significantly increased in estradiol-treated rats. These data are relevant to the care of obese women, in particular perimenopausal women, undergoing bariatric surgery.
authors.affiliation: University of Zurich, Zurich, Switzerland.
authors.forename: Lori
authors.initials: L
authors.lastname: Asarian
authors.forename: Kathrin
authors.initials: K
authors.lastname: Abegg
authors.forename: Nori
authors.initials: N
authors.lastname: Geary
authors.forename: Marc
authors.initials: M
authors.lastname: Schiesser
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Lutz
authors.forename: Marco
authors.initials: M
authors.lastname: Bueter
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology*; D005247:Feeding Behavior; D005260:Female; D015390:Gastric Bypass; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D008593:Menopause; D023421:Models, Animal; D009765:Obesity / Q000378:metabolism / Q000601:surgery*; D010052:Ovariectomy; D051381:Rats; D012527:Satiation / Q000187:drug effects*; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D004967:Estrogens; D004958:Estradiol; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin