title: A genetic variant located in miR-423 is associated with reduced breast cancer risk.
abstract: OBJECTIVE
  Since microRNAs (miRNAs) act as translational regulators of multiple genes, single nucleotide polymorphisms (SNP) in them can have potentially wide-ranging effects. Using an association approach, this research examined the effects of the rs6505162 SNP, an A > C polymorphism located in the pre-miRNA region of miR-423, on breast cancer development.
  
  
  METHODS
  Caucasian Australian women with breast cancer and controls matched for age and ethnicity were genotyped for rs6505162 and their genotypic and allelic frequencies analysed for significant differences.
  
  
  RESULTS
  Analysis indicated that there were significant differences between the case and control populations (χ2 = 6.70, p = 0.035), with the CC genotype conferring reduced risk of breast cancer development (odds ratio = 0.50 95% confidence interval = 0.27-0.92, p = 0.03).
  
  
  CONCLUSIONS
  Further functional research is required to determine the mechanism of action of this SNP on miRNA function.
authors.affiliation: Genomics Research Centre, Griffith Health Institute, Griffith University, QLD, Australia.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Smith
authors.forename: Dominik J
authors.initials: DJ
authors.lastname: Jedlinski
authors.forename: Plamena N
authors.initials: PN
authors.lastname: Gabrovska
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Weinstein
authors.forename: Larisa
authors.initials: L
authors.lastname: Haupt
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C548900:MIRN423 microRNA, human; D035683:MicroRNAs