title: Local activation of cardiac stem cells for post-myocardial infarction cardiac repair.
abstract: The prognosis of patients with myocardial infarction (MI) and resultant chronic heart failure remains extremely poor despite continuous advancements in optimal medical therapy and interventional procedures. Animal experiments and clinical trials using adult stem cell therapy following MI have shown a global improvement of myocardial function. The emergence of stem cell transplantation approaches has recently represented promising alternatives to stimulate myocardial regeneration. Regarding their tissue-specific properties, cardiac stem cells (CSCs) residing within the heart have advantages over other stem cell types to be the best cell source for cell transplantation. However, time-consuming and costly procedures to expanse cells prior to cell transplantation and the reliability of cell culture and expansion may both be major obstacles in the clinical application of CSC-based transplantation therapy after MI. The recognition that the adult heart possesses endogenous CSCs that can regenerate cardiomyocytes and vascular cells has raised the unique therapeutic strategy to reconstitute dead myocardium via activating these cells post-MI. Several strategies, such as growth factors, mircoRNAs and drugs, may be implemented to potentiate endogenous CSCs to repair infarcted heart without cell transplantation. Most molecular and cellular mechanism involved in the process of CSC-based endogenous regeneration after MI is far from understanding. This article reviews current knowledge opening up the possibilities of cardiac repair through CSCs activation in situ in the setting of MI.
authors.affiliation: Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhuzhi
authors.initials: Z
authors.lastname: Wen
authors.forename: Zun
authors.initials: Z
authors.lastname: Mai
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Yangxin
authors.initials: Y
authors.lastname: Chen
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Geng
authors.forename: Shuxian
authors.initials: S
authors.lastname: Zhou
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D002450:Cell Communication; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D035683:MicroRNAs; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology*; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs