title: DAD-6: A 6-ltem version of the Disability Assessment for Dementia scale which may differentiate Alzheimer's disease and mild cognitive impairment from controls.
abstract: BACKGROUND
  The need to detect early changes in instrumental activities of daily life led us to modify the Disability Assessment for Dementia Scale (DAD) by focusing on executive components of 6 instrumental items (DAD-6).
  
  
  OBJECTIVE
  To evaluate the relevance of the DAD-6 for detecting early impairment in a nondemented population.
  
  
  METHODS
  The DAD-6 was administered to informants of 84 patients: 31 with mild dementia (MD), 53 with mild cognitive impairment (MCI) and 55 healthy controls.
  
  
  RESULTS
  DAD-6 scores gradually decreased with increasing severity of the cognitive status [18 in healthy controls vs. 15.1 ± 3.2 in MCI versus 9.6 ± 3.5 in MD, p < 0.0001). Receiver-operating characteristic curve analyses yielded an optimal cut score of 14 to distinguish MCI from MD with a sensitivity of 0.83 (95% confidence interval 0.74-0.92) and a specificity of 0.84 (0.71-0.94), and a cut score of 15 to distinguish single-domain MCI from multi-domain MCI with a sensitivity of 0.96 (0.90-0.99) and a specificity of 0.54 (0.33-0.75).
  
  
  CONCLUSIONS
  The DAD-6 reliably detects early loss of autonomy due to cognitive impairment.
authors.affiliation: Service de Gériatrie, Hôpital Broca, AP-HP, 54-56 rue Pascal, Paris, France. jocelyne.derotrou@brc.aphp.fr
authors.forename: J
authors.initials: J
authors.lastname: de Rotrou
authors.forename: Y-H
authors.initials: YH
authors.lastname: Wu
authors.forename: L
authors.initials: L
authors.lastname: Hugonot-Diener
authors.forename: C
authors.initials: C
authors.lastname: Thomas-Antérion
authors.forename: J-S
authors.initials: JS
authors.lastname: Vidal
authors.forename: M
authors.initials: M
authors.lastname: Plichart
authors.forename: A-S
authors.initials: AS
authors.lastname: Rigaud
authors.forename: O
authors.initials: O
authors.lastname: Hanon
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D016001:Confidence Intervals; D004185:Disability Evaluation; D042241:Early Diagnosis; D056344:Executive Function; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D008297:Male; D016743:Mental Competency; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires