title: Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation consisting of airway obstruction and parenchymal emphysema, with loss of elastic recoil. The forced oscillation technique can detect impairment of lung function by measuring lung impedance during normal tidal breathing. Respiratory resistance (Rrs) in COPD has been well-studied, but the differences in Rrs in the inspiratory and expiratory phases between mild and moderate COPD remain poorly understood. Since airway obstruction in COPD is known to change dynamically during tidal breathing and might affect Rrs, the differences in Rrs during tidal breathing between mild and moderate COPD were evaluated.
  
  
  METHODS
  Mild (n = 13) and moderate (n = 13) COPD patients were recruited at Tokyo University Hospital (Tokyo, Japan). Rrs was measured using MostGraph-01 (Chest MI, Inc, Tokyo, Japan), which depicted Rrs in a frequency-and respiratory cycle-dependent manner in three-dimensional graphics. Rrs was evaluated at 4-35 Hz during tidal breathing.
  
  
  RESULTS
  Rrs changed dynamically during tidal breathing in COPD. The mean Rrs values were significantly greater in the moderate COPD group than in the mild group. The maximal and minimal Rrs values at higher frequencies in the respiratory cycle were significantly greater in moderate COPD. In inspiratory-expiratory breath analysis, the maximal and minimal Rrs values at 20 Hz and 35 Hz were significantly greater in the moderate group, whereas at 4 Hz they did not differ significantly between the groups.
  
  
  CONCLUSIONS
  Rrs changed dynamically during tidal breathing in patients with COPD. The Rrs values at higher frequencies were greater in moderate COPD than in mild COPD. Rrs at higher frequencies might reflect the degree of airway obstruction in tidal breathing in patients with COPD and might be a useful marker for evaluation of airway obstruction at an early stage of COPD.
authors.affiliation: Division of Health Promotion Center, University of Tokyo, Tokyo, Japan. yamauchiy-int@h.u-tokyo.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kohyama
authors.forename: Taisuke
authors.initials: T
authors.lastname: Jo
authors.forename: Takahide
authors.initials: T
authors.lastname: Nagase
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D000403:Airway Resistance; D045853:Exhalation; D005260:Female; D006801:Humans; D001239:Inhalation; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D012129:Respiratory Function Tests / Q000379:methods; D012137:Respiratory System / Q000503:physiopathology; D012720:Severity of Illness Index