title: Nonsteroidal antiinflammatory drugs, acetaminophen, and hypertension.
abstract: Selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) as well as acetaminophen belong to the most widely prescribed therapeutic agents worldwide. Their efficacy in pain relief notwithstanding, the use of NSAIDs is associated with an increased cardiovascular risk, which can be partly attributed to their blood pressure raising potential. Adequately powered placebo-controlled trials specifically evaluating the cardiovascular safety of NSAIDs vs. selective COX inhibitors are currently underway. This review summarizes the current knowledge on the cardiovascular effects of NSAIDs and acetaminophen, and their potential clinical consequences.
authors.affiliation: Cardiovascular Center Cardiology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
authors.forename: Isabella
authors.initials: I
authors.lastname: Sudano
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Flammer
authors.forename: Susanne
authors.initials: S
authors.lastname: Roas
authors.forename: Frank
authors.initials: F
authors.lastname: Enseleit
authors.forename: Georg
authors.initials: G
authors.lastname: Noll
authors.forename: Frank
authors.initials: F
authors.lastname: Ruschitzka
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000494:pharmacology; D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D010146:Pain / Q000188:drug therapy; D012306:Risk
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D000082:Acetaminophen; D001241:Aspirin