title: The PBDE-209 exposure during pregnancy and lactation impairs immune function in rats.
abstract: In the present study, we assessed the treatment effects of PBDE-209 administration on the immune function in rats during pregnancy and lactation. We harvested the blood and organs for flow cytometry, viability assay, enzyme-linked immunosorbent assay, and histological evaluation. The results of this study were the PBDE-209 exposure during pregnancy and lactation impairs immune function in rats. The results may contribute to understanding the mechanism of PBDE-209 in immune function.
authors.affiliation: The Third Affiliated Hospital of Guangzhou Medical College, The Medical Center for Critical Pregnant Women in Guangzhou, Duobao Road, No. 63, Guangzhou 510150, China.
authors.forename: Xianbao
authors.initials: X
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhan
authors.forename: Xu
authors.initials: X
authors.lastname: Zeng
authors.forename: Chunfang
authors.initials: C
authors.lastname: Zhang
authors.forename: Dunjin
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D002470:Cell Survival; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D055768:Halogenated Diphenyl Ethers / Q000494:pharmacology*; D007107:Immune System / Q000187:drug effects*; D007075:Immunoglobulin M / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007774:Lactation / Q000187:drug effects*; D018811:Maternal Exposure; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000378:metabolism
chemical_list: D055768:Halogenated Diphenyl Ethers; D007075:Immunoglobulin M; D015847:Interleukin-4; D007371:Interferon-gamma; D012844:Sincalide; C010902:decabromobiphenyl ether