title: Molecular targets in melanoma: time for 'ethnic personalization'.
abstract: Worldwide, the incidence of melanoma continues to rise. Although not the most common cutaneous malignancy, it is the most lethal. Until recently, while other oncologic patients benefited from the nuances of targeted therapy, those afflicted with melanoma lacked that option. In 2011, the US FDA approved an oral agent that targets the BRAF oncogene. As this information is promising, it is essential that other populations (in addition to Caucasians) are examined, in order to further comprehend the biology of melanoma. Recent studies profiling various ethnicities, including Asians, have provided novel data with respect to the molecular characterization (c-KIT, BRAF, NRAS) of melanoma. It is hopeful that the management of melanoma will be universally applicable to all ethnic groups.
authors.affiliation: The Queen's Medical Center/Queen's Cancer Center, 1301 Punchbowl Street, Honolulu, HI 96813, USA.
authors.forename: Shane Y
authors.initials: SY
authors.lastname: Morita
authors.forename: Svetomir N
authors.initials: SN
authors.lastname: Markovic
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000208:ethnology / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000639:trends; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D057285:Precision Medicine / Q000639:trends; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins