title: Emerging beneficial roles of sirtuins in heart failure.
abstract: Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, seven sirtuins (SIRT1-7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and mitochondria, respectively. They participate in biological functions related to development of heart failure, including regulation of energy production, oxidative stress, intracellular signaling, angiogenesis, autophagy and cell death/survival. Emerging evidence indicates that the two sirtuins play protective roles in failing hearts. Here, we summarize current knowledge of sirtuin functions in the heart and discuss its translation into therapy for heart failure.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan. tannom@sapmed.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Tanno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kuno
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Horio
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002317:Cardiovascular Agents / Q000627:therapeutic use; D016923:Cell Death; D004734:Energy Metabolism; D006333:Heart Failure / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008929:Mitochondria, Heart / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D018919:Neovascularization, Physiologic; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism* / Q000627:therapeutic use; D056566:Sirtuin 3 / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D002317:Cardiovascular Agents; D017382:Reactive Oxygen Species; D056564:Sirtuin 1; D056566:Sirtuin 3; D002118:Calcium