title: High-resolution multi-isotope imaging mass spectrometry enables visualisation of stem cell division and metabolism.
abstract: MIMS visualises metabolism: A recent publication by Steinhauser and co-workers presents a novel application of multi-isotope mass spectrometry (MIMS) to visualise physiological metabolism in live mammalian organisms, and validate the "immortal strand hypothesis" of asymmetric chromosomal division of stem cells in the small intestine.
authors.affiliation: Department of Cell Biology and Anatomy, Hamamatsu University, School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Goto
authors.forename: Michihiko
authors.initials: M
authors.lastname: Waki
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Takahashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Kadowaki
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Setou
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D002455:Cell Division / Q000502:physiology; D020090:Chromosome Segregation; D002875:Chromosomes / Q000737:chemistry; D004330:Drosophila; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D009587:Nitrogen Isotopes; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D002247:Carbon Isotopes; D009587:Nitrogen Isotopes