title: Visceral fat predominance is associated with erosive esophagitis in Japanese men with metabolic syndrome.
abstract: OBJECTIVE
  Although visceral fat is strongly associated with metabolic syndrome (MS), the association between erosive esophagitis (EE) and visceral and subcutaneous fat types in individuals with MS has remained unclear. In this study, we divided individuals with MS into those with visceral and subcutaneous fat types, and determined the differences in the presence of EE between the types of MS in Japanese men.
  
  
  METHODS
  The participants were 265 men with MS who underwent a medical checkup including upper gastrointestinal endoscopy and abdominal ultrasonography. We made a distinction between visceral and subcutaneous fat types of MS by ultrasonography, and examined for the presence of EE, and the correlation between EE and other data.
  
  
  RESULTS
  Total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and the frequency of EE were significantly higher in visceral fat-type MS than in subcutaneous fat-type MS. On logistic regression analysis with EE as a dependent variable and the significant background factors as the independent variables, visceral fat-type MS and hiatal hernia were significant predictors of an increased prevalence of EE (odds ratios=3.808 and 8.599; 95% confidence intervals=1.710-8.479 and 4.206-17.58; P<0.005 and <0.001, respectively).
  
  
  CONCLUSIONS
  Japanese men with visceral fat-type MS are more likely to have dyslipidemia and EE than those with subcutaneous fat-type MS. Visceral fat-type MS is one of the most significant predictors of an increased prevalence of EE in Japanese men with MS.
authors.affiliation: Department of Gastroenterology, Kagawa Prefectural Cancer Detection Center, Takamatsu, Kagawa, Japan. tokushimakenananshi@yahoo.co.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sogabe
authors.forename: Toshiya
authors.initials: T
authors.lastname: Okahisa
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Shingo
authors.initials: S
authors.lastname: Hibino
authors.forename: Akira
authors.initials: A
authors.lastname: Yamanoi
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000209:etiology; D016099:Endoscopy, Gastrointestinal; D004941:Esophagitis / Q000209:etiology*; D006551:Hernia, Hiatal / Q000209:etiology; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000473:pathology*; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D015995:Prevalence; D050151:Subcutaneous Fat / Q000473:pathology*; D014463:Ultrasonography; D055105:Waist Circumference
chemical_list: D008078:Cholesterol, LDL; D000410:Alanine Transaminase