title: Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis.
abstract: Twenty-five derivatives of the natural diterpene leubethanol, including several potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Several compounds showed antimycobacterial potencies similar to that of the lead compound and two of them displayed higher selectivity indexes.
authors.affiliation: Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Perez-Meseguer
authors.forename: Esther
authors.initials: E
authors.lastname: Del Olmo
authors.forename: Blanca
authors.initials: B
authors.lastname: Alanis-Garza
authors.forename: Ricardo
authors.initials: R
authors.lastname: Escarcena
authors.forename: Elvira
authors.initials: E
authors.lastname: Garza-González
authors.forename: Ricardo
authors.initials: R
authors.lastname: Salazar-Aranda
authors.forename: Arturo San
authors.initials: AS
authors.lastname: Feliciano
authors.forename: Noemí Waksman
authors.initials: NW
authors.lastname: de Torres
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes; D011355:Prodrugs; C562290:leubethanol