title: Correlative analysis of neoplasm patients with phlegm-stasis or abnormal Savda syndrome, based on metabonomics.
abstract: OBJECTIVE
  To investigate plasma samples from neoplasm patients with phlegm-stasis or abnormal Savda syndrome, with NMR spectroscopy, and to analyze their metabolic varieties, characteristics and reciprocity.
  
  
  METHODS
  1H-NMR spectra were analyzed using the orthogonal projection to latent structure with discriminative analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of metabolites was determined by the Pearson's product - moment correlation coefficient.
  
  
  RESULTS
  Compared to the control group, neoplasm patients with phlegm - stasis or abnormal Savda syndrome had low concentrations of leucine, isoleucine, valine, alanine, tyrosine, histidine, citrulline, glycoprotein, glutamine, myo-inositol, scyllo-inositol, creatine, alpha-glucose, alpha-glucose and lactate (P < 0.05), and high concentrations of very low density lipoprotein, low density lipoprotein, unsaturated lipid, formate, acetone, acetate, acetoacetate, pyruvate, beta-hydroxybutyrate, carnitine and malonic acid (P < 0.05), with no significant differences between the phlegm - stasis and abnormal Savda syndrome patients.
  
  
  CONCLUSIONS
  Neoplasm patients with different syndromes have very similar metabolic changes. A series of abnormalities such as immune dysfunction and oxidative - antioxidative imbalance, occur in neoplasm patients with abnormal Savda or phlegm - stasis syndrome.
authors.affiliation: College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Mamtimin
authors.initials: M
authors.lastname: Batur
authors.forename: Upur
authors.initials: U
authors.lastname: Halmurat
authors.forename: Fu-Hua
authors.initials: FH
authors.lastname: Hao
authors.forename: Rena
authors.initials: R
authors.lastname: Aiziz
authors.forename: Matsidik
authors.initials: M
authors.lastname: Aynur
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics; D009369:Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism*; D013183:Sputum / Q000737:chemistry*