title: Cyclin D1 G870A polymorphism contributes to colorectal cancer susceptibility: evidence from a systematic review of 22 case-control studies.
abstract: BACKGROUND
  Cyclin D1 (CCND1) plays a vital role in cancer cell cycle progression. Numerous epidemiological studies have evaluated the association between the CCND1 G870A polymorphism and the risk of colorectal cancer. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, we conducted a meta-analysis and systematic review.
  
  
  RESULTS
  A comprehensive search was conducted to identify eligible studies of the CCND1 G870A polymorphism and colorectal cancer risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. We applied a grading system (Venice criteria) that assessed the epidemiological strength of the association. A total of 22 publications that included 6157 cases and 8198 controls were identified. We found that the CCND1 G870A polymorphism was significantly associated with overall colorectal cancer risk (homozygote genetic model: OR = 1.130, 95% CI = 1.023-1.248, P = 0.016; heterozygote genetic model: OR = 1.124, 95% CI = 1.030-1.226, P = 0.009; dominant genetic model: OR = 1.127, 95% CI = 1.037-1.224, P = 0.005). After further stratified analyses, the increased risk was observed only in the subgroups of hospital-based studies, PCR-RFLP genotyping methods, sporadic colorectal cancer, and Caucasian ethnicity.
  
  
  CONCLUSIONS
  The available evidence demonstrates that the CCND1 870A allele might be a low-penetrant risk factor for colorectal cancer.
authors.affiliation: Department of Surgery, Shanghai Tenth People's Hospital affiliated with Tongji University, Shanghai, People's Republic of China.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Chenzhang
authors.initials: C
authors.lastname: Shi
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.forename: Huanlong
authors.initials: H
authors.lastname: Qin
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D019940:Genes, bcl-1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1