title: [Clinical significance of detecting peripheral blood T lymphocyte subsets in patients with pulmonary adenocarcinoma].
abstract: OBJECTIVE
  To evaluate the clinical value of T lymphocyte subsets in prediction of chemotherapy responses of patients with pulmonary adenocarcinoma.
  
  
  METHODS
  Fifty-five chemotherapy-naive patients with pathologically or cytologically confirmed pulmonary adenocarcinoma were examined for peripheral blood T lymphocyte subsets using flow cytometry, including CD3(+) T cells, CD3(+)CD4(+) T cells, CD3(+)CD8(+) T cells, CD45RO(+) T cells and CD45RA(+) T cells.
  
  
  RESULTS
  Patients who responded favorably to chemotherapy (CR(+)PR) showed a significantly lower percentage of CD45RA(+) T cells than those who failed to respond to chemotherapy (P=0.04). CD45RO(+) T cell percentage were slightly higher in the response group than in the non-response group, but this difference was not statistically significant (P=0.25). The other T cell subsets, namely CD3(+), CD3(+)CD4(+), and CD3(+)CD8(+) T cells showed no significant differences between the two groups.
  
  
  CONCLUSIONS
  A high percentage of peripheral blood CD45RA(+) T cells is associated with a poor short-term outcome of chemotherapy in patients with advanced pulmonary adenocarcinoma. Peripheral blood CD45RA(+) T cell level can be a reliable index for predicting chemotherapy efficacy in these patients.
authors.affiliation: Department of Medical Oncology, General Hospital of PLA, Beijing, China. dr.zx@163.com
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.forename: Shengjie
authors.initials: S
authors.lastname: Sun
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wu
authors.forename: Shunchang
authors.initials: S
authors.lastname: Jiao
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D017493:Leukocyte Common Antigens