title: Effects of aurothiomalate and gold(III) complexes on spontaneous motility of isolated human oviduct.
abstract: Organic gold complexes have different biological activity, depending on their potential for interactions with key functional molecules.The aim of this study was to investigate potential of several newly synthesized organic gold complexes to influence spontaneous motility of the Fallopian tubes.The effects of [Au(bipy)Cl(2)](+) (dichloride(2,2'-bipyridyl)aurate(III)-ion), aurothiomalate, [Au(DMSO)(2)Cl(2)]Cl and DMSO on spontaneous motility of Fallopian tubes were tested on the isolated tube segments in vitro. Aurothiomalate (from 2.9 × 10(-9) to 4.9 × 10(-4) M/l), [Au(bipy)Cl(2)]Cl (from 3.3 × 10(-9) to 4.2 × 10(-5) M/l) and DMSO (from 1.9 × 10(-8) to 1.0 × 10(-5) M/l) did not affect spontaneous contractions of the isolated Fallopian tube ampulla, while [Au(DMSO)(2)Cl(2)]Cl (from 2.9 × 10(-9) to 4.2 × 10(-5) M/l) showed concentration-dependent increase (stimulation) of spontaneous contractions of the isolated Fallopian tube isthmus, and remained without effect on the isolated ampulla.The drugs designed as organic gold complexes with weaker bonds between the gold itself and organic part of a molecule could adversely affect motility of the Fallopian tubes, and theoretically fertility of women taking such drugs in their reproductive age.
authors.affiliation: Department of Pharmacology and Toxicology, Medical Faculty, University of Kragujevac, Ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia. slobodan.jankovic@medf.kg.ac.rs
authors.forename: Slobodan M
authors.initials: SM
authors.lastname: Janković
authors.forename: Ana
authors.initials: A
authors.lastname: Djeković
authors.forename: Zivadin
authors.initials: Z
authors.lastname: Bugarčić
authors.forename: Snezana V
authors.initials: SV
authors.lastname: Janković
authors.forename: Goran
authors.initials: G
authors.lastname: Lukić
authors.forename: Marko
authors.initials: M
authors.lastname: Folić
authors.forename: Dragan
authors.initials: D
authors.lastname: Canović
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000503:physiopathology; D005187:Fallopian Tubes / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D050607:Organogold Compounds / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D018501:Antirheumatic Agents; D050607:Organogold Compounds; D006052:Gold Sodium Thiomalate