title: [Antimicrobial agents and renal elimination: towards individual dosage adjustment?].
abstract: The efficacy and safety of anti-infective treatments are associated with the drug blood concentration profile, which is directly correlated with a dosing adjustment to the individual patient's condition. Dosing adjustments to the renal function recommended in reference books are often imprecise and infrequently applied in clinical practice. The recent generalisation of the KDOQI (Kidney Disease Outcome Quality Initiative) staging of chronically impaired renal function represents an opportunity to review and refine the dosing recommendations in patients with renal insufficiency. The literature has been reviewed and compared to a predictive model of the fraction of drug cleared by the kidney based on the Dettli's principle. Revised drug dosing recommendations integrating these predictive parameters are proposed.
authors.affiliation: Division de pharmacologie et toxicologie cliniques, Département des laboratoires, CHUV, Lausanne. corinne.robatel@chuv.ch
authors.forename: C
authors.initials: C
authors.lastname: Willi-Robatel
authors.forename: L
authors.initials: L
authors.lastname: Senn
authors.forename: F
authors.initials: F
authors.lastname: Livio
authors.forename: G
authors.initials: G
authors.lastname: Zanetti
authors.forename: O
authors.initials: O
authors.lastname: Marchetti
authors.forename: T
authors.initials: T
authors.lastname: Buclin
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D006801:Humans; D008658:Inactivation, Metabolic / Q000502:physiology*; D007668:Kidney / Q000378:metabolism*; D008657:Metabolic Clearance Rate / Q000502:physiology; D017410:Practice Guidelines as Topic; D057285:Precision Medicine / Q000379:methods / Q000639:trends*
chemical_list: D000890:Anti-Infective Agents