title: Improvement of refractory migraine headache by propofol: case series.
abstract: BACKGROUND
  Several studies have been conducted on managing migraine headaches and developing effective medications for decreasing migraine-associated pain.
  
  
  METHODS
  Intravenous propofol was prescribed (10 mg every 5 min) for eight patients with intractable migraine headaches visiting the Emergency Department. The average pain score experienced by patients was recorded using the Visual Analogue Scale at the beginning of the treatment procedure and following the injection for 30 min (5-min intervals). The patients' reported pain scores decreased significantly (P = 0.01) from 8.87 ± 0.83 (CI: 8.17, 9.57) to 1.12 ± 0.83 (CI: 0.43, 1.82) before and 30 min following the injection.
  
  
  CONCLUSIONS
  It seems that in the treatment of intractable migraine headaches, GABAergic receptors, compared to the normal conditions, have a lower activity status.
  
  
  CONCLUSIONS
  Because of the high tendency of propofol to GABAergic receptors, it probably changes this physiological condition by activating the receptors, which results in a significant pain reduction.
authors.affiliation: Emergency Medicine Department, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, 51664, Iran. soleimanpourh@tbzmed.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Soleimanpour
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Taheraghdam
authors.forename: Rouzbeh Rajaei
authors.initials: RR
authors.lastname: Ghafouri
authors.forename: Ali
authors.initials: A
authors.lastname: Taghizadieh
authors.forename: Karim
authors.initials: K
authors.lastname: Marjany
authors.forename: Maryam
authors.initials: M
authors.lastname: Soleimanpour