title: Using germline genomics to individualize pediatric cancer treatments.
abstract: The amazing successes in cure rates for children with cancer over the last century have come in large part from identifying clinical, genetic, and molecular variables associated with response to therapy in large cooperative clinical trials and stratifying therapies according to the predicted risk of relapse. There is an expanding interest in identifying germline genomic variants, as opposed to genetic variants within the tumor, that are associated with susceptibility to toxicity and for risk of relapse. This review highlights the most important germline pharmacogenetic and pharmacogenomic studies in pediatric oncology. Incorporating germline genomics into risk-adapted therapies will likely lead to safer and more effective treatments for children with cancer.
authors.affiliation: Department of Pediatrics and Medicine, and Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, Illinois 60637, USA. npinto1@peds.bsd.uchicago.edu
authors.forename: Navin
authors.initials: N
authors.lastname: Pinto
authors.forename: Susan L
authors.initials: SL
authors.lastname: Cohn
authors.forename: M Eileen
authors.initials: ME
authors.lastname: Dolan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D023281:Genomics; D005854:Germ Cells; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor