title: Operative risks of domino liver transplantation for the FAP liver donor and the FAP liver recipient.
abstract: This study aimed at evaluating the operative risks of domino liver transplantation (LT). Two retrospective analyses were conducted (comparison of familial amyloid polyneuropathy (FAP) liver donors [61 patients] versus FAP nondonors [39 patients] and FAP liver recipients [61 patients] versus cadaveric liver recipients [61 patients]). First analysis showed a 60-day mortality of 6.6% for FAP donors and 7.7% for FAP nondonors (p = 1.0). Both groups had similar vascular and biliary complication rates. Both groups had similar 1- and 5-year patient and graft survival rates (83.4 % versus 87.2%, and 79.8 % versus 71.8%, p = 0.7) and (83.3% versus 87.2%, and 79.1% versus 71.8%, p = 0.7). The second analysis showed a 1.6% mortality for FAP liver recipients versus 3.2% of the control group (p = 1). Both groups had similar morbidity and technical complication rates (18.0% versus 13.1%, p = 0.45) and (0.18 versus 0.15, p = 0.65). Domino procedure doesn't add any risk to FAP donor or recipient. It increases the organ pool allowing transplantation of marginal recipients who otherwise are denied cadaveric LT.
authors.affiliation: AP-HP Hôpital Henri Mondor, Créteil, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
authors.forename: Chady
authors.initials: C
authors.lastname: Salloum
authors.forename: Didier
authors.initials: D
authors.lastname: Samuel
authors.forename: Violaine
authors.initials: V
authors.lastname: Planté-Bordeneuve
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D012189:Retrospective Studies; D014180:Transplantation