title: Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice.
abstract: Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and adulthood consumption of HFD induce similar morphometric and metabolic changes. However, only juvenile exposure to HFD abolishes relational memory flexibility, assessed after initial radial-maze concurrent spatial discrimination learning, and decreases neurogenesis. Our results identify a critical period of development covering adolescence with higher sensitivity to HFD-induced hippocampal dysfunction at both behavioral and cellular levels.
authors.affiliation: INRA, Nutrition et Neurobiologie Intégrée, UMR1286, F-33000 Bordeaux, France.
authors.forename: Chloe
authors.initials: C
authors.lastname: Boitard
authors.forename: Nicole
authors.initials: N
authors.lastname: Etchamendy
authors.forename: Julie
authors.initials: J
authors.lastname: Sauvant
authors.forename: Agnes
authors.initials: A
authors.lastname: Aubert
authors.forename: Sophie
authors.initials: S
authors.lastname: Tronel
authors.forename: Aline
authors.initials: A
authors.lastname: Marighetto
authors.forename: Sophie
authors.initials: S
authors.lastname: Layé
authors.forename: Guillaume
authors.initials: G
authors.lastname: Ferreira
mesh_terms: D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D018891:Dentate Gyrus / Q000737:chemistry / Q000473:pathology; D059305:Diet, High-Fat / Q000009:adverse effects*; D004193:Discrimination Learning / Q000187:drug effects; D000089622:Doublecortin Domain Proteins; D002149:Energy Intake / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007124:Immunoenzyme Techniques; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D055495:Neurogenesis / Q000187:drug effects*; D009479:Neuropeptides / Q000032:analysis; D050177:Overweight / Q000097:blood / Q000209:etiology*; D013037:Spatial Behavior / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D000089622:Doublecortin Domain Proteins; D020738:Leptin; D008055:Lipids; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D003345:Corticosterone