title: Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole-substituted 9-anilinoacridine derivatives.
abstract: A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a-j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell line. The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme. All the isoxazole-substituted compounds have significant activities.
authors.affiliation: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Tamilnadu Ootacamund 643001, India. rkalirajan@ymail.com
authors.forename: R
authors.initials: R
authors.lastname: Kalirajan
authors.forename: M H Mohammed
authors.initials: MH
authors.lastname: Rafick
authors.forename: S
authors.initials: S
authors.lastname: Sankar
authors.forename: S
authors.initials: S
authors.lastname: Jubie
mesh_terms: D000609:Aminoacridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001667:Binding, Competitive; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D000609:Aminoacridines; D000970:Antineoplastic Agents; D000975:Antioxidants; D007555:Isoxazoles; D004247:DNA