title: Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds.
abstract: First synthesis of novel coumarin-trioxane hybrids is reported. The synthesis was achieved via condensation of β-hydroxyhydroperoxides with coumarinic-aldehydes in presence of p-toluenesulfonic acid in good yields and the novel hybrids were evaluated for their antimalarial activity both in vitro and in vivo.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226 001, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Abdhesh
authors.initials: A
authors.lastname: Kumar
authors.forename: Ranga Prasad
authors.initials: RP
authors.lastname: Dodda
authors.forename: Naikade Niraj
authors.initials: NN
authors.lastname: Krishna
authors.forename: Pooja
authors.initials: P
authors.lastname: Agarwal
authors.forename: Kumkum
authors.initials: K
authors.lastname: Srivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D001557:Benzenesulfonates / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D051379:Mice; D010545:Peroxides / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000469:parasitology; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000469:parasitology; D013329:Structure-Activity Relationship
chemical_list: C503429:1,2,4-trioxane; D000447:Aldehydes; D000962:Antimalarials; D001557:Benzenesulfonates; D003374:Coumarins; D006571:Heterocyclic Compounds; D010545:Peroxides; C029501:4-toluenesulfonic acid