title: Effects of systemic sitafloxacin on periodontal infection control in elderly patients.
abstract: OBJECTIVE
  To evaluate the microbiological and clinical effects of the systemic administration of sitafloxacin (STFX) on periodontal pockets in elderly patients receiving supportive periodontal therapy (SPT).
  
  
  BACKGROUND
  Periodontitis is a risk factor for atherosclerosis. Better periodontal health contributes to reduce atherosclerosis-related diseases in elderly population.
  
  
  METHODS
  Forty-four patients undergoing SPT were randomly assigned to two groups: a test group took 100 mg/day of STFX for five consecutive days, or a control group received scaling and root planing (SRP) under local anaesthesia. Microbiological and clinical parameters were examined at baseline and at 1 and 3 months after therapy.
  
  
  RESULTS
  The presence of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia was significantly reduced at 1 month after treatment in both groups. The median reductions of the bacteria between the baseline and 1 month were 3.08 and 2.54% in the STFX- and SRP-treated groups, respectively. Both treatments significantly decreased the probing depth at 1 and 3 months compared to the baseline.
  
  
  CONCLUSIONS
  The systemic administration of STFX is effective at improving periodontal health during SPT and could be an alternative to SRP for elderly patients who cannot undergo anaesthesia or are at risk of tissue injury.
authors.affiliation: Center for Transdisciplinary Research, Niigata University, Niigata, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Nakajima
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okui
authors.forename: Sayuri
authors.initials: S
authors.lastname: Miyauchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Honda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Shimada
authors.forename: Harue
authors.initials: H
authors.lastname: Ito
authors.forename: Kohei
authors.initials: K
authors.lastname: Akazawa
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D058491:Bacterial Load / Q000187:drug effects; D001439:Bacteroides / Q000187:drug effects; D055113:Chronic Periodontitis / Q000382:microbiology* / Q000628:therapy; D003773:Dental Plaque / Q000382:microbiology / Q000628:therapy; D012534:Dental Scaling; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000382:microbiology / Q000628:therapy; D010514:Periodontal Pocket / Q000382:microbiology* / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000276:immunology; D018713:Prevotella intermedia / Q000187:drug effects; D016745:Root Planing; D048373:Treponema denticola / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D024841:Fluoroquinolones; C076246:sitafloxacin