title: Hb S [β6(A3)Glu→Val, GAG>GTG] and β-globin gene cluster haplotype distribution in Mauritania.
abstract: Of 1050 Mauritanian blood donors screened from the two main racial groups, i.e., the Moors and Black Africans, 60 were found to carry Hb S [β6(A3)Glu→Val, GAG>GTG], giving a global frequency of 5.71%. The prevalence observed in the Black African Mauritanians (10.69%) is almost five times that found in the Moor group (2.25%). Four of the five main β(S) haplotypes were detected in this study: Senegal (77.8%), Benin (8.8%), Arab-Indian (5.5%) and Bantu (4.4%). These data showed that Hb S is a serious public health problem in Mauritania. They also confirm the ethnic heterogeneity of the Mauritanian population.
authors.affiliation: Départment de Biologie, Faculté des Sciences et Techniques, Nouakchott, Mauritanie.
authors.forename: Fatimetou M
authors.initials: FM
authors.lastname: Veten
authors.forename: Isselmou O
authors.initials: IO
authors.lastname: Abdelhamid
authors.forename: Ghlana M
authors.initials: GM
authors.lastname: Meiloud
authors.forename: Sidi M
authors.initials: SM
authors.lastname: Ghaber
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Salem
authors.forename: Salem
authors.initials: S
authors.lastname: Abbes
authors.forename: Ahmed O
authors.initials: AO
authors.lastname: Houmeida
mesh_terms: D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006801:Humans; D008297:Male; D008435:Mauritania; D005810:Multigene Family / Q000235:genetics*; D055544:beta-Globins / Q000235:genetics*
chemical_list: D006451:Hemoglobin, Sickle; D055544:beta-Globins