title: Arresting cancer proliferation by controlling the surface crystallinity of carbon materials without generating reactive oxygen species.
abstract: This study demonstrated that the surface crystallinity of carbon nanostructures is an additional independent factor that should be considered for the inhibition of cancer proliferation without activating reactive oxygen species (ROS). In addition, cytotoxic evaluation of both proliferating cancer cells and fully differentiated nerve cells (i.e. non-proliferative) showed selective cytotoxicity: single-walled and highly crystalline carbon nanostructures aggressively inhibited the proliferation of glioma cancer cells, but exhibited no notable cytotoxicity effects on differentiated nerve cells. Although single-wall carbon nanotubes have been shown to elicit potent proinflammatory responses by means of trigger ROS, our results demonstrated that highly crystalline carbon structures can be utilized as a selective antiproliferative agent against brain tumor cells without increasing the ROS level and without significant cytotoxic effects to adjacent nerve cells.
authors.affiliation: Department of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University, Jinju 660-751, South Korea.
authors.forename: Jungil
authors.initials: J
authors.lastname: Choi
authors.forename: Soyoung
authors.initials: S
authors.lastname: Lee
authors.forename: Wenping
authors.initials: W
authors.lastname: Wang
authors.forename: Soo-Hyun
authors.initials: SH
authors.lastname: Hahm
authors.forename: Ye Sun
authors.initials: YS
authors.lastname: Han
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Nam
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Dongwoo
authors.initials: D
authors.lastname: Khang
mesh_terms: D017209:Apoptosis; D015153:Blotting, Western; D002244:Carbon / Q000737:chemistry*; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D002244:Carbon