title: Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones: addition to imines.
abstract: Access to chiral isoindolinones: The Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones is described. A Bu(2) Mg/Schiff base catalyst (1:1) promoted the enantioselective addition of N-Boc-isoindolinones to aryl, heteroaryl, alkenyl, and alkyl imines, giving 3-substituted isoindolinones in 84-99 % ee and 50:50-91:9 d.r. (see scheme).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yudai
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Motomu
authors.initials: M
authors.lastname: Kanai
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007097:Imines; D007211:Indoles; D008274:Magnesium