title: [Incidence and clinical impact of seizures after surgery for chronic subdural haematoma].
abstract: OBJECTIVE
  Seizures can occur in patients who have surgery for a chronic subdural hematoma. However, the incidence of seizures and their impact on the clinical course of patients in the perioperative period is not well known.
  
  
  METHODS
  In this retrospective study, we reviewed 161 cases of patients treated for chronic subdural hematoma in our institution. The surgical procedures consisted in trephine craniotomy in 156 cases, burr-hole craniotomy in three cases, and bone flap craniotomy in two cases. All the patients had systematic antiepileptic drug prophylaxis.
  
  
  RESULTS
  In our patients' population, the incidence of seizures was 10.6% before surgery and 14.9% after surgery. Low initial score on the Glasgow Coma Scale (P<0.001) and preoperative cognitive impairment (P=0.005) were associated with a higher rate of postoperative seizures. In our study, the mortality rate was 14.9%. Low initial score on the Glasgow Coma Scale (P=0.068) and postoperative seizures (P=0.002) were associated with a higher mortality rate.
  
  
  CONCLUSIONS
  We have shown that patients suffering from seizures may have worse outcome. The benefit of a systematic perioperative prophylaxis using antiepileptic drugs has to be evaluated.
authors.affiliation: Service de neurochirurgie, hôpital Nord, chemin des Bourrely, 13915 Marseille cedex 20, France. fabrice.battaglia@ap-hm.fr
authors.forename: F
authors.initials: F
authors.lastname: Battaglia
authors.forename: V
authors.initials: V
authors.lastname: Lubrano
authors.forename: T
authors.initials: T
authors.lastname: Ribeiro-Filho
authors.forename: V
authors.initials: V
authors.lastname: Pradel
authors.forename: P-H
authors.initials: PH
authors.lastname: Roche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology; D003399:Craniotomy; D005260:Female; D015600:Glasgow Coma Scale; D020200:Hematoma, Subdural, Chronic / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D011859:Radiography; D012008:Recurrence; D012189:Retrospective Studies; D012640:Seizures / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality
chemical_list: D000927:Anticonvulsants