title: Automated screening of inhibitors of bacterial dissimilatory sulfate reduction.
abstract: An automated assay system was used to screen inhibitors of sulfide formation by sulfate-reducing bacteria. The system used a Technicon AutoAnalyzer II instrument both as an incubation chamber (to combine bacterial cells, substrates, and test compounds) and as an analyzer of the amount of sulfide formed during incubation. A lactate-limited chemostat was used to provide a reproducible inoculum of Desulfovibrio desulfuricans cells. The assay was useful in detecting even small changes in the rate of sulfate reduction resulting from exposure to inhibitors.
authors.affiliation: Central Research and Development Department, E. I. DuPont de Nemours and Company, Inc., Experimental Station, 19898, Wilmington, Delaware, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Weimer
authors.forename: F B
authors.initials: FB
authors.lastname: Cooling