title: Soluble C-X-C chemokine ligand 16 levels are increased in gout patients.
abstract: OBJECTIVE
  Soluble C-X-C chemokine ligand 16 (CXCL16) was shown to recruit polymorphonuclear cells into synovial tissue in gout patients. The aim of this study was to explore the pathophysiological characteristics of CXCL16 in gout patients with or without chronic kidney disease (CKD).
  
  
  METHODS
  42 gout patients, 22 CKD and 20 healthy subjects were enrolled. Plasma CXCL16 and other biochemical parameters were tested.
  
  
  RESULTS
  Plasma CXCL16 levels in gout subjects with CKD were significantly increased compared with healthy, CKD and gout subjects without CKD. Soluble CXCL16 levels in gout subjects were closely correlated with renal function and lipid profiles, and independently associated with 24h proteinuria, creatinine clearance rate and C-reactive protein.
  
  
  CONCLUSIONS
  Our data indicated that plasma CXCL16 levels are significantly increased in gout patients with and without CKD, and are independently associated with renal function. Elucidating the pathophysiologcial role of CXCL16 in gout patients requires further study.
authors.affiliation: School of Pharmacy, Wenzhou Medical College, Chashan College Park, Wenzhou 325035, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gong
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.forename: Xuebo
authors.initials: X
authors.lastname: Pan
authors.forename: Jiawen
authors.initials: J
authors.lastname: Yu
authors.forename: Yilan
authors.initials: Y
authors.lastname: Li
authors.forename: Tingting
authors.initials: T
authors.lastname: Lu
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Li
authors.forename: Zhuofeng
authors.initials: Z
authors.lastname: Lin
mesh_terms: D000368:Aged; D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC / Q000097:blood* / Q000235:genetics; D003404:Creatinine / Q000097:blood; D005260:Female; D006073:Gout / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007963:Leukocytes, Mononuclear; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000503:physiopathology; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics; D051116:Receptors, Scavenger / Q000097:blood* / Q000235:genetics; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: C423727:CXCL16 protein, human; D000075743:Chemokine CXCL16; D019743:Chemokines, CXC; D008055:Lipids; D012333:RNA, Messenger; D051116:Receptors, Scavenger; D002097:C-Reactive Protein; D003404:Creatinine