title: [Chemoprevention of oral cancer--clinical and experimental studies].
abstract: Chemoprevention is one of the cancer prevention methods, applied for the oral squamous cell carcinoma and its main precursor lesions--leukoplakia and erythroplakia. Presently, the most extensive clinically studied group used in such cases are retinoids: vitamin A (retinol), 13-cis-retinic acid (isotretinoin), N-(4-hydroxyphenyl)retinamide (fenretinide) and precursor of vitamin A--beta-carotene. However, despite good short-time effectiveness, retinoids do not prevent recurrences of the lesions and insignificantly increase cancer-free survival. Moreover, they are also characterized by relatively high toxicity. Vitamin E, Bowman-Birkprotease inhibitor, Spirulina fusiformis and green tee extracts as well as traditional Chinese herbs known as ZengShengPing were also found as effective agents. Lack of activity was reported for cyclooxygenase inhibitors--ketorolac and celecoxib. More promising data was collected from animal experimental studies with chemically induced oral squamous cell carcinoma. Chemopreventive activity was revealed for various agents including plant-derived compounds like resveratrol, green and black tee polyphenols, as well as protocatechuic, ellagic and caffeic acids.
authors.affiliation: Department of Clinical Pathomorphology, Medical University of Lublin, Poland. jszumilo@wp.pl
authors.forename: Justyna
authors.initials: J
authors.lastname: Szumiło
authors.forename: Justyna
authors.initials: J
authors.lastname: Podlodowska
authors.forename: Wiktor
authors.initials: W
authors.lastname: Podlodowski
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Starosławska
authors.forename: Franciszek
authors.initials: F
authors.lastname: Burdan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D018890:Chemoprevention; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D017313:Fenretinide / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D009062:Mouth Neoplasms / Q000517:prevention & control*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000188:drug therapy*; D014801:Vitamin A / Q000627:therapeutic use; D019207:beta Carotene / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D019207:beta Carotene; D014801:Vitamin A; D017313:Fenretinide; D015474:Isotretinoin