title: Mean peak systolic velocity of the superior thyroid artery is correlated with radioactive iodine uptake in untreated thyrotoxicosis.
abstract: OBJECTIVE
  To evaluate the correlation between mean superior thyroid artery peak systolic velocity (STA-PSV) and radioactive iodine uptake (RAIU) in Chinese patients with untreated thyrotoxicosis, using retrospectively and prospectively collected data.
  
  
  METHODS
  Patients with untreated  thyrotoxicosis (n = 220) and euthyroid control subjects (n = 30) underwent thyroid function, thyroid autoantibody and thyroid ultrasonography tests. Mean STA-PSV was measured by ultrasonography. RAIU tests identified 168 patients with Graves' disease and 52 with destructive  thyroiditis. Linear correlation of mean STA-PSV with 3-h and 24-h RAIU, and sensitivity, specificity and receiver operating characteristic (ROC) curves for mean STA-PSV in the differential diagnosis of Graves' disease and destructive thyroiditis were calculated.
  
  
  RESULTS
  Mean STA-PSV  was significantly higher in Graves' disease than in destructive thyroiditis. Mean STA-PSV correlated positively and significantly with 3-h and 24-h RAIU. Area under the ROC curve of mean STA-PSV for the differential diagnosis of Graves' disease and destructive thyroiditis was 0.825  (optimum cut-off value of mean STA-PSV, 45.25 cm/s; sensitivity, 80.4%; specificity, 81.4%).
  
  
  CONCLUSIONS
  Detection of mean STA-PSV by ultrasonography agrees with RAIU and is useful for the differential diagnosis of thyrotoxicosis in Chinese patients.
authors.affiliation: Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Hu
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002342:Carotid Artery, External / Q000000981:diagnostic imaging*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011446:Prospective Studies; D012039:Regional Blood Flow; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000098:blood supply* / Q000000981:diagnostic imaging; D013966:Thyroiditis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013971:Thyrotoxicosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes