title: Kiamycin, a unique cytotoxic angucyclinone derivative from a marine Streptomyces sp.
abstract: Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data. The new angucyclinone derivative showed inhibitory activities against the human cell lines HL-60 (leukemia), A549 (lung adenocarcinoma), and BEL-7402 (hepatoma) with inhibition rates of 68.2%, 55.9%, and 31.7%, respectively, at 100 µM. It appears to have potential as an anticancer agent with selective activity.
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.|Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zeping
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany.
authors.forename: Hongpeng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Chemical Biological Research Institute, College of Science, Northwest A & F University, Yangling 712100, China.
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.|Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Naiyun
authors.initials: N
authors.lastname: Ji
authors.affiliation: Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
authors.forename: Song
authors.initials: S
authors.lastname: Qin
authors.affiliation: Department of Organic and Biomolecular Chemistry, University of Göttingen, Göttingen D-37077, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012623:Seawater; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; C510997:angucyclinone; C575073:kiamycin