title: Infliximab in the treatment of amyloidosis secondary to Crohn's disease.
abstract: Secondary amyloidosis (AA) is a severe complication of progressed Crohn&rsquo;s disease (CD) for which no effective treatment exists. We present the exceptional case of a 33 year-old male with moderate renal failure and proteinuria, who was simultaneously diagnosed with AA amyloid nephropathy and oligosymptomatic CD. He was treated with infliximab at 5mg/kg/8 weeks for 4 years, azathioprine at 1-1.5mg/kg/day (first year) and renin-angiotensin-aldosterone system blockers, with no complications. Treatment caused a decrease in proteinuria, improved renal function, and improved inflammatory parameters over time. Inspired by this case, we performed a review of the medical literature and found that infliximab could be a useful tool in the early treatment of amyloidosis secondary to CD.
authors.affiliation: Hospital General Universitario Reina Sofía, Murcia, Spain. juanbecaro@gmail.com
authors.forename: Juan B
authors.initials: JB
authors.lastname: Cabezuelo
authors.forename: Juan P
authors.initials: JP
authors.lastname: Egea
authors.forename: Fernanda
authors.initials: F
authors.lastname: Ramos
authors.forename: Emilio
authors.initials: E
authors.lastname: Torrella
authors.forename: Salomé
authors.initials: S
authors.lastname: Muray
authors.forename: Concepción
authors.initials: C
authors.lastname: Alcázar
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis; D003680:Deglutition Disorders / Q000209:etiology; D004359:Drug Therapy, Combination; D006801:Humans; D000069285:Infliximab; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000209:etiology; D012084:Renin-Angiotensin System / Q000187:drug effects; D000685:Serum Amyloid A Protein
chemical_list: D000911:Antibodies, Monoclonal; D000685:Serum Amyloid A Protein; D000069285:Infliximab; D001379:Azathioprine