title: Effects of bushen huoxue yin on brain NF-kB and NO content in the Parkinson's disease model mouse.
abstract: OBJECTIVE
  To observe the effects of Bushen Huoxue Yin on nuclear transcription factor kappa B (NF-KB) and nitric oxide (NO) in the brain of the Parkinson's disease (PD) model mouse.
  
  
  METHODS
  Forty-five C57BL/6 mice were randomly divided into three groups; normal, model and BSHXY treatment groups. Concentrations of NF-KB and NO in mouse brain tissue were determined by ELISA and spectrophotometry, respectively.
  
  
  RESULTS
  NF-KB concentration in brain tissue in the model group was 14.04 +/- 4.38 microg x L(-1), which was higher than that in normal (P < 0.01) and BSHXY (P < 0.05) groups. NO content in brain tissue in the model group was 5.93 +/- 0.79 micromol x gprot(-1), which was also higher than that in model (P < 0.01) and BSHXY (P < 0.01) groups. However, there were no significant differences in the content of NF-KB and NO between BSHXY and normal groups (P > 0.05).
  
  
  CONCLUSIONS
  The mechanism of BSHXY for treatment of PD is possibly related to inhibition of NF-KB activation and decreased NO content in the brain.
authors.affiliation: Institute of Traditional Chinese Medicine, PLA General Hospital, Beijing 100853, China. lsd301@126.com
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Yang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; C527851:bushen huoxue; D009569:Nitric Oxide