title: Two antimycin A analogues from marine-derived actinomycete Streptomyces lusitanus.
abstract: Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 μg/mL, respectively.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.|Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.|Graduate School of the Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Han
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: John I. Haas, Inc., Yakima, WA 98902, USA.
authors.forename: Oliver
authors.initials: O
authors.lastname: McConnell
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Liu
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Qi
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Xiangzhong
authors.initials: X
authors.lastname: Huang
authors.affiliation: Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Qian
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology*; D059001:Aquatic Organisms; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D013912:Threonine / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D007202:Indicators and Reagents; D007783:Lactones; C575075:antimycin B1; C575076:antimycin B2; D013912:Threonine; D000968:Antimycin A