title: Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche.
abstract: Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known about how non-associated immune cells contribute to cancer biology. In a recent issue of the Journal of Pathology, He and colleagues use non-invasive, high-resolution imaging of the whole living animal to provide a compelling glimpse at how physiological migration of neutrophils can prepare a metastatic niche and how their activities can be altered by the unintended consequences of targeted therapeutics.
authors.affiliation: MRC Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh, UK. e.patton@igmm.ed.ac.uk
authors.forename: E Elizabeth
authors.initials: EE
authors.lastname: Patton
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009504:Neutrophils / Q000502:physiology*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors*; D023041:Xenograft Model Antitumor Assays; D015027:Zebrafish / Q000196:embryology*
chemical_list: D040262:Receptors, Vascular Endothelial Growth Factor