title: Modifications on the basic skeletons of vinblastine and vincristine.
abstract: The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor agents vinblastine and vincristine so as to obtain novel compounds with improved therapeutic properties.
authors.affiliation: Department of Organic Chemistry and Technology, University of Technology and Economics, H-1111 Budapest, Szt. Gellért tér 4, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Keglevich
authors.forename: László
authors.initials: L
authors.lastname: Hazai
authors.forename: György
authors.initials: G
authors.lastname: Kalaus
authors.forename: Csaba
authors.initials: C
authors.lastname: Szántay
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D058451:Oxidative Coupling; D014747:Vinblastine / Q000031:analogs & derivatives / Q000737:chemistry*; D014750:Vincristine / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; C009667:vindoline; D014750:Vincristine; D014747:Vinblastine