title: Antioxidant potential and protection of pancreatic β- cells by Calotropis gigantea in streptozocin induced diabetic rats.
abstract: This study was designed to examine the antioxidant defense by chloroform extract of Calotropis gigantea on streptozotocin-(40mg/kg, intraperitonial, single-injection) induced diabetes in wistar albino rats. The extract significantly (P < .05) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P < .05) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats. The results of test drug were comparable to Glibenclamide (5mg/kg, daily), a standard antihyperglycemic agent. The study concludes that Calotropis gigantea enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and this protects β-cells against loss, and exhibit antidiabetic property.
authors.affiliation: Dept of Chemistry & Pharmaceutical Chemistry, Banasthali Vidhyapeeth.
authors.forename: Naveen Kumar
authors.initials: NK
authors.lastname: Choudhary
authors.forename: Swapnil
authors.initials: S
authors.lastname: Sharma
authors.forename: A K
authors.initials: AK
authors.lastname: Jha
authors.forename: Manvendra Singh
authors.initials: MS
authors.lastname: Karchuli
authors.forename: Jaya
authors.initials: J
authors.lastname: Dwivedi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D031107:Calotropis / Q000737:chemistry; D002725:Chloroform; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004334:Drug Administration Schedule; D005260:Female; D035264:Flowers / Q000737:chemistry; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D013311:Streptozocin; D002725:Chloroform