title: Whole body diffusion for metastatic disease assessment in neuroendocrine carcinomas: comparison with OctreoScan® in two cases.
abstract: Neuroendocrine tumor (NET) patients must be adequately staged in order to improve a multidisciplinary approach and optimal management for metastatic disease. Currently available imaging studies include somatostatin receptor scintigraphy, like OctreoScan®, computed tomography (CT), scans and magnetic resonance imaging (MRI), which analyze vascular concentration and intravenous contrast enhancement for anatomic tumor localization. However, these techniques require high degree of expertise for interpretation and are limited by their availability, cost, reproducibility, and follow-up imaging comparisons. NETs significantly reduce water diffusion as compared to normal tissue. Diffusion-weighted imaging (DWI) in MRI has an advantageous contrast difference: the tumor is represented with high signal over a black normal surrounding background. The whole-body diffusion (WBD) technique has been suggested to be a useful test for detecting metastasis from various anatomic sites. In this article we report the use of DWI in MRI and WBD in two cases of metastatic pulmonary NET staging in comparison with OctreoScan® in order to illustrate the potential advantage of DWI and WBD in staging NETs.
authors.affiliation: Centro de Oncologia, Hospital Sírio Libanês, Rua Dona Adma Jafet 91, São Paulo 01308-050, Brazil.
authors.forename: Rachel Jorge D
authors.initials: RJ
authors.lastname: Cossetti
authors.forename: Regis Otaviano França
authors.initials: RO
authors.lastname: Bezerra
authors.forename: Brenda
authors.initials: B
authors.lastname: Gumz
authors.forename: Adriana
authors.initials: A
authors.lastname: Telles
authors.forename: Frederico P
authors.initials: FP
authors.lastname: Costa
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis; D001984:Bronchial Neoplasms / Q000473:pathology; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D013004:Somatostatin / Q000031:analogs & derivatives*; D014057:Tomography, X-Ray Computed / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide