title: Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones.
abstract: N-Phenylsulfonyl (S)-proline catalyzes the direct aldol reaction of 3-substituted cyclobutanones and aryl aldehydes in good yield and with excellent diastereoselectivity and enantioselectivity. This desymmetrization process provides highly functionalized cyclobutanones with control over three contiguous stereogenic centers.
authors.affiliation: Laboratoire de Synthèse Organique et Méthodologie, Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO - CNRS UMR 8182), Université Paris-Sud 11, 15 rue Georges Clemenceau, 91405 Orsay, France.
authors.forename: David J
authors.initials: DJ
authors.lastname: Aitken
authors.forename: Angela M
authors.initials: AM
authors.lastname: Bernard
authors.forename: Francesca
authors.initials: F
authors.lastname: Capitta
authors.forename: Angelo
authors.initials: A
authors.lastname: Frongia
authors.forename: Régis
authors.initials: R
authors.lastname: Guillot
authors.forename: Jean
authors.initials: J
authors.lastname: Ollivier
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Piras
authors.forename: Francesco
authors.initials: F
authors.lastname: Secci
authors.forename: Marco
authors.initials: M
authors.lastname: Spiga