title: The art of "cut and run": the role of Rab14 GTPase in regulating N-cadherin shedding and cell motility.
abstract: Linford et al. define a Rab14-mediated endocytic recycling pathway that controls proteolytic N-cadherin cleavage by transporting ADAM10 protease to the plasma membrane. When this pathway is disrupted, diminished ADAM10-dependent N-cadherin shedding leads to increased cell-cell adhesion and inhibition of cell motility.
authors.affiliation: Department of Cell and Developmental Biology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. rytis.prekeris@ucdenver.edu
authors.forename: Rytis
authors.initials: R
authors.lastname: Prekeris