title: Analysis of bone formation after sinus augmentation using β-tricalcium phosphate.
abstract: Implant placement in the edentulous maxilla often represents a clinical challenge due to insufficient bone height after crestal bone resorption and maxillary sinus pneumatization. Several graft materials have been evaluated for augmenting the maxillary sinus to compensate for the lost vertical dimension. Allografts are readily available without the risk of disease transmission and the need for a second site surgery. The aim of this case series was to systematically evaluate the development and maturation of augmented bone in the maxillary sinus using beta-tricalcium phosphate. In 21 to 40 weeks post-sinus elevation, bone biopsies were taken and implants placed simultaneously. All specimens were demineralized and subjected to staining procedures (ie, Hematoxylin and Eosin [H&E], Goldner's staining, and tartrate-resistant acid phosphatase [TRAP]). Total bone increased over time, whereas the amount of graft material diminished. A lack of inflammatory reaction was noticed with the use of this graft material. In addition, TRAP staining revealed the presence of osteoclasts surrounding the remaining particles. During a 12-month follow-up, no implant failure or complications were observed.
authors.affiliation: Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, New York, USA.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schulze-Späte
authors.forename: Thomas
authors.initials: T
authors.lastname: Dietrich
authors.forename: Rayyan A
authors.initials: RA
authors.lastname: Kayal
authors.forename: Hatice
authors.initials: H
authors.lastname: Hasturk
authors.forename: Justine
authors.initials: J
authors.lastname: Dobeck
authors.forename: Ziedonis
authors.initials: Z
authors.lastname: Skobe
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
mesh_terms: D020341:Absorbable Implants; D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D003094:Collagen; D004396:Coloring Agents; D003758:Dental Implantation, Endosseous / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology*; D059546:Sinus Floor Augmentation / Q000379:methods*; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D015415:Biomarkers; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004396:Coloring Agents; D007527:Isoenzymes; D008567:Membranes, Artificial; C485817:beta-tricalcium phosphate; D003094:Collagen; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase