title: Decreased plasma nesfatin-1 levels in patients with generalized anxiety disorder.
abstract: Nesfatin-1, a recently discovered satiety molecule, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances. However, the relation between nesfatin-1 and stressor related behaviors like anxiety and/or fear has not yet been investigated in human subjects. In the present study, our aim was to investigate whether there was a relationship between plasma nesfatin-1 levels and generalized anxiety disorder. The study group consisted of 40 patients (BMI, 22.98 ± 0.56) with generalized anxiety disorder and 34 age-matched healthy male control subjects (23.05 ± 0.4). Patients fully met the fourth Diagnostic and Statistical Manual of Mental Disorders, text revision. Blood samples for nesfatin-1 were drawn at the end of an overnight fasting period at least 10h. Plasma nesfatin-1 levels were measured and found significantly lower in anxiety disorder group than in control group (0.35 ± 0.037 ng/ml vs. 0.63 ± 0.080 ng/ml, respectively, p<0.05). Low nesfatin-1 levels may be related with generalized anxiety disorder.
authors.affiliation: Department of Psychiatry, Etimesgut Military Hospital, Ankara, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Gunay
authors.forename: Recep
authors.initials: R
authors.lastname: Tutuncu
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.forename: Ersel
authors.initials: E
authors.lastname: Dag
authors.forename: Dilek
authors.initials: D
authors.lastname: Abasli
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005215:Fasting / Q000097:blood; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins