title: PTK7 as a novel marker for favorable gastric cancer patient survival.
abstract: OBJECTIVE
  Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.
  
  
  METHODS
  PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.
  
  
  RESULTS
  PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).
  
  
  CONCLUSIONS
  Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.
authors.affiliation: Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
authors.forename: Lian-Hai
authors.initials: LH
authors.lastname: Zhang
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Xing
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Cheng
authors.forename: Bin
authors.initials: B
authors.lastname: Dong
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.forename: Ying-Ai
authors.initials: YA
authors.lastname: Li
authors.forename: Yu-Bing
authors.initials: YB
authors.lastname: Zhu
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Du
authors.forename: Ji-You
authors.initials: JY
authors.lastname: Li
authors.forename: Jia-Fu
authors.initials: JF
authors.lastname: Ji
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C096905:PTK7 protein, human; D020794:Receptor Protein-Tyrosine Kinases