title: [Effect of L-arabinose on glucose and lipid metabolism in type 2 diabetic rats].
abstract: OBJECTIVE
  To investigate the effect of L-arabinose on glucose and Organ and islet in type 2 diabetic rats.
  
  
  METHODS
  Male Wistar rats were fed high-sugar and high-fat diet after 8 weeks, then inject streptozotocin intraperitoneally according to 25 mg/kgbw dose to establish animal models of type 2 diabetes, and fed L-arabinose according to a low dose (50 mg/kgbw ), medium dose (150 mg/kgbw) and high dose (500 mg/kgbw) ,the animal be fed acarbose (20 mg/kgbw) as a positive control, the use of L-arabinose and acarbose were prepared in the dextrin (0.36 g/ml) and sucrose (0.04 g/ml) of the suspension, free to eat water. OGTT after 4 weeks, After animal death, rat liver, epididymal fat and cecum were weighed and calculate the ratio of organ weight. Results compared with model group, low, animals with L-arabinose-intervention those blood glucose response had a significant impact, 30 min, 60 min, 120 min blood glucose values and AUC were significantly lower than the model group (P < 0.05), of which medium dose is most significant (P < 0.01). L-arabinose intervention increased cecal weight and showed protective effect on beta-cell.
  
  
  CONCLUSIONS
  L-arabinose long-term intervention can improve glucose tolerance in type 2 diabetic rats, this effect may be related to L-arabinose inhibition of digestive enzymes and the protective effect on beta-cell.
authors.affiliation: Food Science and Technology Institute of Hunan Agricultural University, Changsha 410128, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Yao
authors.forename: Yin
authors.initials: Y
authors.lastname: Ying
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Zhu
authors.initials: Z
authors.lastname: Wang
authors.forename: Xuesong
authors.initials: X
authors.lastname: Xiang
authors.forename: Youjin
authors.initials: Y
authors.lastname: Yi
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D001089:Arabinose / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D005951:Glucose Tolerance Test; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D008055:Lipids; D001089:Arabinose