title: Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs.
abstract: It is recognized that mycotoxins can cause a variety of adverse health effects in animals, including altered gastrointestinal barrier function. It is the aim of the present study to determine whether mycotoxin-contaminated diets can alter the oral bioavailability of the antibiotics doxycycline and paromomycin in pigs, and whether a mycotoxin adsorbing agent included into diets interacts with those antibiotics. Experiments were conducted with pigs utilizing diets that contained blank feed, mycotoxin-contaminated feed (T-2 toxin or deoxynivalenol), mycotoxin-contaminated feed supplemented with a glucomannan mycotoxin binder, or blank feed supplemented with mycotoxin binder. Diets with T-2 toxin and binder or deoxynivalenol and binder induced increased plasma concentrations of doxycycline administered as single bolus in pigs compared to diets containing blank feed. These results suggest that complex interactions may occur between mycotoxins, mycotoxin binders, and antibiotics which could alter antibiotic bioavailability. This could have consequences for animal toxicity, withdrawal time for oral antibiotics, or public health.
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Joline.Goossens@ugent.be
authors.forename: Joline
authors.initials: J
authors.lastname: Goossens
authors.forename: Virginie
authors.initials: V
authors.lastname: Vandenbroucke
authors.forename: Frank
authors.initials: F
authors.lastname: Pasmans
authors.forename: Siegrid
authors.initials: S
authors.lastname: De Baere
authors.forename: Mathias
authors.initials: M
authors.lastname: Devreese
authors.forename: Ann
authors.initials: A
authors.lastname: Osselaere
authors.forename: Elin
authors.initials: E
authors.lastname: Verbrugghe
authors.forename: Freddy
authors.initials: F
authors.lastname: Haesebrouck
authors.forename: Sarah
authors.initials: S
authors.lastname: De Saeger
authors.forename: Mia
authors.initials: M
authors.lastname: Eeckhout
authors.forename: Kris
authors.initials: K
authors.lastname: Audenaert
authors.forename: Geert
authors.initials: G
authors.lastname: Haesaert
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
mesh_terms: D000327:Adsorption; D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004032:Diet; D004318:Doxycycline / Q000097:blood / Q000493:pharmacokinetics*; D008351:Mannans / Q000008:administration & dosage* / Q000737:chemistry; D010303:Paromomycin / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine; D013605:T-2 Toxin / Q000008:administration & dosage* / Q000737:chemistry; D014255:Trichothecenes / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D008351:Mannans; D014255:Trichothecenes; C022901:(1-6)-alpha-glucomannan; D010303:Paromomycin; D013605:T-2 Toxin; C007262:deoxynivalenol; D004318:Doxycycline