title: Leiden V factor and spastic cerebral palsy in Mexican children.
abstract: OBJECTIVE
  Cerebral palsy (CP) is a persistent motor disorder that appears before the patient is 3 years old due to a nonprogressive interference in the brain's development which takes place before the central nervous system growth is complete. Causes of this have been studied, and one that has been proposed for spastic hemiparesis CP is the Leiden mutation of V factor coagulation. We want to know whether this mutation can cause CP in our population.
  
  
  METHODS
  We carried out a study of cases and controls with 94 patients with spastic hemiparesis CP and 120 controls as well as their mothers with their controls.
  
  
  RESULTS
  None of the patients, their mothers, or controls had the Leiden mutation; however, other risk factors were significant: hypoxia odds ratio (OR) 7.189 (2.546, 20.302) p=0.0001, smoking OR 16.621 (2.945, 93.818) p=0.001, maternal infections (urinary or vaginal) OR 7.040 (2.952, 16.789) p=0.0001, weeks of gestation OR 0.866 (0.7750, 0.999) p=0.048, and maternal age OR 1.114 (1.031, 1.204) p=0.006.
  
  
  CONCLUSIONS
  Leiden mutation of factor V is not an important factor for our Mexican mestizo population; however, there are other important perinatal risk factors.
authors.affiliation: Genetics Department, National Institute of Rehabilitation, Mexico City, México. mlarenassordo@hotmail.com
authors.forename: María de la Luz
authors.initials: Mde L
authors.lastname: Arenas-Sordo
authors.forename: César
authors.initials: C
authors.lastname: Zavala-Hernández
authors.forename: César
authors.initials: C
authors.lastname: Casiano-Rosas
authors.forename: Elba
authors.initials: E
authors.lastname: Reyes-Maldonado
authors.forename: Camilo
authors.initials: C
authors.lastname: Ríos
authors.forename: Edgar
authors.initials: E
authors.lastname: Hernández-Zamora
authors.forename: Martha G
authors.initials: MG
authors.lastname: Del Valle-Cabrera
authors.forename: Jesús K
authors.initials: JK
authors.lastname: Yamamoto-Furusho
mesh_terms: D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000235:genetics*; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008800:Mexico; D009154:Mutation; D012307:Risk Factors
chemical_list: C095381:factor V Leiden; D005165:Factor V