title: Genetic study on developmental dysplasia of the hip.
abstract: BACKGROUND
  Developmental dysplasia of the hip (DDH) is a developmental disorder of the hip joint that results in an abnormal socket of the femoral head, ranging from instability, subluxation and complete dislocation of the hip joint. DDH has a considerable genetic component.
  
  
  METHODS
  We reviewed the recent progress on genetic study of DDH.
  
  
  RESULTS
  By linkage and case-control association studies, DDH loci have been identified with several susceptibility genes that involve in bone and joint biology; however, no unequivocal genes with global significance have been detected. The current problem of the association study in DDH is discussed.
  
  
  CONCLUSIONS
  By advanced technologies and international collaboration, we need to find more susceptibility genes and bridge the gap between genetic evidence and molecular mechanisms.
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China.
authors.forename: Dongquan
authors.initials: D
authors.lastname: Shi
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D016022:Case-Control Studies; D005544:Forecasting; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006618:Hip Dislocation, Congenital / Q000235:genetics*; D006801:Humans