title: [Effect of the composition and structure of the drug delivery device on the drug release rate].
abstract: To investigate the effects of the property of drugs and the structure of drug delivery devices on the drug release rate, the effects of sealing methods, length, thickness and drug-loading manner of the silicone tubes on the drug release rate were examined using progestin, testosterone, estradiol as the delivery drugs. The results showed that the property of the drug was the crucial factor to the drug release rate. The sealing methods, length, thickness and drug status of the silicone tubes had significant effects on the drug release rate and the effects were closely related to the property of the drugs. In addition, our newly developed glass-silicone tube has larger drug deposition capability and smaller drug release area, offers an effective and convenient method for the sustained drug delivery with quick release traits in vivo.
authors.affiliation: Medical College, Dalian University, Dalian 116622, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wang
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D004958:Estradiol / Q000008:administration & dosage; D045167:Progesterone Congeners / Q000008:administration & dosage; D012828:Silicones; D013739:Testosterone / Q000008:administration & dosage
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D045167:Progesterone Congeners; D012828:Silicones; D013739:Testosterone; D004958:Estradiol