title: Predictive value of global longitudinal strain in a surgical population of organic mitral regurgitation.
abstract: BACKGROUND
  Because of the lack of reliable echocardiographic parameters to predict recovery after surgery, the optimal timing of surgery for severe mitral regurgitation remains controversial. The aim of this study was to determine whether global longitudinal strain (GLS) recorded preoperatively could help in predicting left ventricular (LV) ejection fraction (LVEF) postoperatively.
  
  
  METHODS
  A total of 88 patients (mean age, 63 ± 13 years; 59 men) with severe degenerative mitral regurgitation were included prospectively in this study. Rest echocardiography was performed before and 6 ± 1 months after mitral valve surgery. Patients were divided into two groups: group A (postoperative LVEF ≥ 50%) and group B (postoperative LVEF < 50%).
  
  
  RESULTS
  In group B, patients had larger preoperative LV end-systolic diameters (21.6 ± 2.6 vs 19.2 ± 3.7 mm/m(2), P = .02) and impaired preoperative GLS (-17 ± 2.8% vs -19.6 ± 3.6%, P = .01), whereas there was no difference in preoperative LVEF. Preoperative LV end-systolic diameter ≥ 22 mm/m(2) and GLS < -18% were independent predictors of postoperative LV dysfunction.
  
  
  CONCLUSIONS
  LV end-systolic diameter is a well-recognized prognostic marker. In addition, this study demonstrates the additive and independent predictive value of preoperative GLS for predicting postoperative LV dysfunction.
authors.affiliation: Department of Cardiology, CIT-IC 804, INSERM U642 LTSI, Hospital Pontchaillou-University Medical Center, Rennes, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Mascle
authors.forename: Frederic
authors.initials: F
authors.lastname: Schnell
authors.forename: Christophe
authors.initials: C
authors.lastname: Thebault
authors.forename: Herve
authors.initials: H
authors.lastname: Corbineau
authors.forename: Marcel
authors.initials: M
authors.lastname: Laurent
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hamonic
authors.forename: David
authors.initials: D
authors.lastname: Veillard
authors.forename: Philippe
authors.initials: P
authors.lastname: Mabo
authors.forename: Alain
authors.initials: A
authors.lastname: Leguerrier
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
mesh_terms: D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*