title: Effect of bowel cleansing for colonoscopy on fecal calprotectin levels in pediatric patients.
abstract: The recent development of easily applicable fecal surrogate markers of intestinal inflammation, such as fecal calprotectin (FC), has provided a new means for objectively assessing disease activity in patients with chronic inflammatory bowel disease. Because the use of these markers is about to emerge, it is important to be aware of the possible limitations of measurements. We assessed levels of FC during bowel cleansing. In patients with high FC levels at baseline, the values measured during bowel cleansing varied considerably, remaining high or even returning to normal. Thus, stool sampling for FC assessment is not recommended during bowel preparation for colonoscopy.
authors.affiliation: Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. kaija-leena.kolho@helsinki.fi
authors.forename: Kaija-Leena
authors.initials: KL
authors.lastname: Kolho
authors.forename: Henrik
authors.initials: H
authors.lastname: Alfthan
authors.forename: Esa
authors.initials: E
authors.lastname: Hämäläinen
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002400:Cathartics; D002648:Child; D002908:Chronic Disease; D003106:Colon / Q000378:metabolism*; D003113:Colonoscopy; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D002400:Cathartics; D039841:Leukocyte L1 Antigen Complex