title: [Present state of in vitro and in vivo studies on efficacy of medical nonspecific protective agents with respect to genotype IV coronavirus causing severe acute respiratory syndrome].
abstract: The results of the in vitro studies on the efficacy of medical nonspecific protective agents from various pharmacological groups showed that some drugs, such as velferon, alferon, betaferon, ribavirin and lopinavir were active against TOPC virus, that permitted to recommend them for estimation of their activity on laboratory animals. The data on the in vivo activity of pharmacological drugs with respect to TOPC virus are rather scanty and it is difficult to predetermine their efficacy. The danger of TOPC virus latent circulation among wild animals in China requires research of new efficient medical agents for protection of the people from the pathogen in the Russian Federation.
authors.forename: V N
authors.initials: VN
authors.lastname: Shchukina
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Loginova
authors.forename: S V
authors.initials: SV
authors.lastname: Borisevich
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D002522:Chlorocebus aethiops; D004197:Disease Reservoirs / Q000821:virology; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology / Q000627:therapeutic use; D000068576:Interferon beta-1b; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use; D016899:Interferon-beta / Q000494:pharmacology / Q000627:therapeutic use; D061466:Lopinavir / Q000494:pharmacology / Q000627:therapeutic use; D012254:Ribavirin / Q000494:pharmacology / Q000627:therapeutic use; D012426:Russia / Q000453:epidemiology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects*; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy* / Q000517:prevention & control; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D016898:Interferon-alpha; D000068576:Interferon beta-1b; D061466:Lopinavir; D012254:Ribavirin; D016899:Interferon-beta