title: [Clinical-pathogenetic features of meningococcal infection in children].
abstract: Analysis features of clinical manifestation and pathogenetic mechanisms of development of meningococcal infection is introduced. It is emphasized that in most cases mentioned infection is characterized by mild course as nasopharyngitidis. However relatively seldom developing generalize form put this phatology on third place after intestinal infections and septicemia in structure of child mortality from infection deseases. Occurence of generalize forms of meningococcal infection depend on peculiarity of immune response is followed by release of endotoxin and exotoxin in blood stream. This toxins start up pathogenetic mechanisms, which lead to toxic shock, adrenal glands hemorrhage, brain edema, brain stem wedge in big occipital foramen.
authors.forename: V N
authors.initials: VN
authors.lastname: Buriak
authors.forename: A S
authors.initials: AS
authors.lastname: Serhyenko
mesh_terms: D002648:Child; D006801:Humans; D008585:Meningitis, Meningococcal / Q000188:drug therapy / Q000473:pathology*; D008589:Meningococcal Infections / Q000188:drug therapy / Q000473:pathology*