title: Increase in total antioxidant capacity of plasma despite high levels of oxidative stress in uncomplicated type 2 diabetes mellitus.
abstract: OBJECTIVE
  Oxidative stress is implicated in the pathophysiology of diabetes mellitus and its chronic complications. The aim of this study was to evaluate plasma antioxidant status in patients with uncomplicated type 2 diabetes, in order to understand the interactions between its components  and the diabetic milieu.
  
  
  METHODS
  Plasma samples were collected from 15 patients with type 2 diabetes receiving oral antidiabetic agents and from 18 healthy control subjects without diabetes. Glycosylated haemoglobin was measured as an indicator of blood glucose control. Total and residual  antioxidant activities were measured. Lipid peroxides were measured as indicators of plasma oxidative stress. Copper and caeruloplasmin were also assayed as possible pro-oxidants.
  
  
  RESULTS
  Antioxidant activities, lipid peroxide level, copper concentration and caeruloplasmin activity were significantly  increased in the plasma of patients with diabetes compared with control subjects.
  
  
  CONCLUSIONS
  The total antioxidant capacity of plasma was increased, despite high levels of oxidative stress, in patients with uncomplicated type 2 diabetes. Increased levels of copper and caeruloplasmin characterized  the diabetic milieu, despite an absence of chronic complications.
authors.affiliation: National Institute of Diabetes, Nutrition and Metabolic Diseases 'NC Paulescu', Bucharest, Romania.
authors.forename: O
authors.initials: O
authors.lastname: Savu
authors.forename: C
authors.initials: C
authors.lastname: Ionescu-Tirgoviste
authors.forename: V
authors.initials: V
authors.lastname: Atanasiu
authors.forename: L
authors.initials: L
authors.lastname: Gaman
authors.forename: R
authors.initials: R
authors.lastname: Papacocea
authors.forename: I
authors.initials: I
authors.lastname: Stoian
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D002570:Ceruloplasmin; D003300:Copper; D006442:Glycated Hemoglobin; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species