title: Comparison of the effects of pulsatile cardiopulmonary bypass, non-pulsatile cardiopulmonary bypass and off-pump coronary artery bypass grafting on the respiratory system and serum carbonyl.
abstract: BACKGROUND
  We aimed to investigate the effects of off-pump coronary artery bypass grafting (CABG), pulsatile cardiopulmonary bypass (CPB), and non-pulsatile CPB techniques on oxidative stress and the respiratory system in the current study.
  
  
  METHODS
  The patients were allocated into three different groups according to perfusion techniques, as follows: off-pump CABG group (n=10); pulsatile CPB (n=11); and non-pulsatile CPB group (n=11). Serum carbonyl level was measured and a pulmonary function test was performed preoperatively and postoperatively.
  
  
  RESULTS
  The postoperative increase in the carbonyl level was significantly lower in the off-pump CABG group compared to the other two groups, while there was no significant difference between the pulsatile and non-pulsatile CPB groups with respect to carbonyl levels. Arterial partial pressure of oxygen, forced expiratory volume in one second, and forced vital capacity were significantly higher in the off-pump CABG group compared to other two groups in the postoperative period.
  
  
  CONCLUSIONS
  We found that off-pump CABG had less negative effects on oxidative stress and the respiratory system compared to pulsatile CPB and non-pulsatile CPB techniques. Additionally, there was no significant difference between pulsatile and non-pulsatile CPB.
authors.affiliation: Department of Cardiovascular Surgery, Gazi University Faculty of Medicine, Ankara, Turkey. drhuseyinbayram@gmail.com
authors.forename: H
authors.initials: H
authors.lastname: Bayram
authors.forename: D
authors.initials: D
authors.lastname: Erer
authors.forename: E
authors.initials: E
authors.lastname: Iriz
authors.forename: M
authors.initials: M
authors.lastname: Hakan Zor
authors.forename: O
authors.initials: O
authors.lastname: Gulbahar
authors.forename: M E
authors.initials: ME
authors.lastname: Ozdogan
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D001026:Coronary Artery Bypass / Q000379:methods*; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011184:Postoperative Period; D011446:Prospective Studies; D015656:Respiratory Mechanics / Q000502:physiology*
chemical_list: D001798:Blood Proteins; D010100:Oxygen