title: MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF.
abstract: MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.
authors.affiliation: Institute of Molecular and Chemical Biology, East China Normal University, Shanghai, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zou
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Mao
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Chuanxiu
authors.initials: C
authors.lastname: Bian
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Liu
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Chen
authors.forename: Yanting
authors.initials: Y
authors.lastname: Qi
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuejing
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
authors.forename: Hsiang-Fu
authors.initials: HF
authors.lastname: Kung
authors.forename: Marie C
authors.initials: MC
authors.lastname: Lin
authors.forename: Andreas
authors.initials: A
authors.lastname: Dress
authors.forename: Fiona
authors.initials: F
authors.lastname: Wardle
authors.forename: Bing-Hua
authors.initials: BH
authors.lastname: Jiang
authors.forename: Lihui
authors.initials: L
authors.lastname: Lai
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D015536:Down-Regulation; D005260:Female; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D014183:Transplantation, Heterologous; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: C541010:MIRN145 microRNA, human; D035683:MicroRNAs; D042461:Vascular Endothelial Growth Factor A; D018631:ras Proteins