title: Standardization and utilization of biobank resources in clinical protein science with examples of emerging applications.
abstract: Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most "omic" activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining the full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes.
authors.affiliation: Clinical Protein Science & Imaging, Biomedical Center, Department of Measurement Technology and Industrial Electrical Engineering, Lund University, BMC C13, SE-221 84 Lund, Sweden. Gyorgy.Marko-Varga@elmat.lth.se
authors.forename: György
authors.initials: G
authors.lastname: Marko-Varga
authors.forename: Ákos
authors.initials: Á
authors.lastname: Végvári
authors.forename: Charlotte
authors.initials: C
authors.lastname: Welinder
authors.forename: Henrik
authors.initials: H
authors.lastname: Lindberg
authors.forename: Melinda
authors.initials: M
authors.lastname: Rezeli
authors.forename: Goutham
authors.initials: G
authors.lastname: Edula
authors.forename: Katrin J
authors.initials: KJ
authors.lastname: Svensson
authors.forename: Mattias
authors.initials: M
authors.lastname: Belting
authors.forename: Thomas
authors.initials: T
authors.lastname: Laurell
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Fehniger
mesh_terms: D018070:Biological Specimen Banks; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins