title: Allergic fungal sinusitis in children.
abstract: Allergic fungal sinusitis (AFS) is a subtype of eosinophilic chronic rhinosinusitis (CRS) characterized by type I hypersensitivity, nasal polyposis, characteristic computed tomography scan findings, eosinophilic mucus, and the presence of fungus on surgical specimens without evidence of tissue invasion. This refractory subtype of CRS is of the great interest in the pediatric population, given the relatively early age of onset and the difficulty in managing AFS through commercially available medical regimens. Almost universally, a diagnosis of AFS requires operative intervention. Postoperative adjuvant medical therapy is a mainstay in the treatment paradigm of pediatric AFS.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Campus Box #7070, Chapel Hill, NC 27599-7070, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Thorp
authors.forename: Kibwei A
authors.initials: KA
authors.lastname: McKinney
authors.forename: Austin S
authors.initials: AS
authors.lastname: Rose
authors.forename: Charles S
authors.initials: CS
authors.lastname: Ebert
mesh_terms: D002648:Child; D002908:Chronic Disease; D004724:Endoscopy; D004804:Eosinophils; D005938:Glucocorticoids; D006801:Humans; D007167:Immunotherapy; D009181:Mycoses / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000601:surgery; D011859:Radiography; D012221:Rhinitis, Allergic, Perennial / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*; D012852:Sinusitis / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy*
chemical_list: D005938:Glucocorticoids