title: Bone grafts as vancomycin carriers in local therapy of resistant infections.
abstract: The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to what extent vancomycin (Van) bound to ground bone grafts is usable in the treatment of serious infections. The levels of released Van significantly exceeded the Van minimum inhibitory concentration, which can suppress Van-sensitive staphylococci and Van intermediate Staphylococcus aureus, for the whole period of a 16-day measurement. Our results indicate that bone grafts can be used as Van carriers in therapy of osteomyelitis caused by Van-sensitive Staphylococcus strains.
authors.affiliation: First Clinic of Orthopedics, Charles University, First Faculty of Medicine and Motol Faculty Hospital, V Úvalu 84, 150 06, Prague 5, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Melicherčík
authors.forename: D
authors.initials: D
authors.lastname: Jahoda
authors.forename: O
authors.initials: O
authors.lastname: Nyč
authors.forename: E
authors.initials: E
authors.lastname: Klapková
authors.forename: V
authors.initials: V
authors.lastname: Barták
authors.forename: I
authors.initials: I
authors.lastname: Landor
authors.forename: D
authors.initials: D
authors.lastname: Pokorný
authors.forename: T
authors.initials: T
authors.lastname: Judl
authors.forename: A
authors.initials: A
authors.lastname: Sosna
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016025:Bone Transplantation; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D014640:Vancomycin