title: The effect of introducing inpatient mandatory generic drug substitution at Ramathobodi Hospital.
abstract: BACKGROUND
  Generic substitution is a mechanism for reducing drug expenditure in many healthcare settings. Ramathibodi, a teaching hospital, has introduced mandatory generic drug substitution (228 items) for health schemes in inpatient service since September 1, 2009.
  
  
  OBJECTIVE
  Explore prescribing patterns in overall and by patients' health schemes between Thai fiscal year 2009 and 2010, and estimate possible saving if this policy was extended to the outpatient service.
  
  
  METHODS
  Prescribing data and registered populations between October 1, 2008 and September 30, 2010 were retrieved from the database and analyzed.
  
  
  RESULTS
  Original and generic expenditure rose 8.42 and 8.61%from 2009 to 2010 respectively. Among 228 mandatory items, more original was switched to generic drugs, both in terms of value (6.5 to 7.2%) and in terms of volume (32.5 to 33.8%). Some inpatients, mainly civil servants and self-pay patients, requested the original from the outpatient service where the mandatory substitution was not applied. If the policy were extended through all services, the government would save approximately 306.5 million Baht (US$ 10.1 million) per year However the hospital would reduce its profit by 53.1 million Baht (US$ 1.7 million).
  
  
  CONCLUSIONS
  After the policy was launched, more original mandatory drugs were switched to generic. To gain more saving, the policy may be expanded to outpatient service, and/or mandatory drug list should be reviewed periodically.
authors.affiliation: Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. raskj@mahidol.ac.th
authors.forename: Sming
authors.initials: S
authors.lastname: Kaojarern
authors.forename: Oraluck
authors.initials: O
authors.lastname: Pattanaprateep
mesh_terms: D016527:Drug Costs; D057915:Drug Substitution / Q000191:economics* / Q000706:statistics & numerical data*; D004363:Drug Utilization / Q000191:economics / Q000706:statistics & numerical data*; D016568:Drugs, Generic / Q000191:economics* / Q000627:therapeutic use; D006760:Hospitalization; D006784:Hospitals, Teaching; D006801:Humans; D010818:Practice Patterns, Physicians'; D013785:Thailand
chemical_list: D016568:Drugs, Generic