title: Contamination of ultrapure water with bisphenol A leached from polysulfone ultrafilter.
abstract: Ultrapure water produced by a water purification system is one of the most essential and widely used reagents in laboratories. However, its quality is usually the least well-characterized and often overlooked. Here we investigate the contamination of ultrapure water by bisphenol A (BPA) leached from a polysulfone (PS) ultrafilter in a water purification system. To evaluate the level of BPA in ultrapure water, we used an offline solid-phase extraction (SPE) coupled with liquid chromatography mass spectrometry (LC-MS). Initial BPA level leached from a new PS ultrafilter was 0.70±0.06 ng/mL. The concentration of BPA decreased gradually with continuous dispensation of purified water and was 0.20±0.02 ng/mL at 33.5-L dispensation. The total amount of extractable BPA was 64.4±1.4 μg per PS ultrafilter. The cumulative amount of BPA leached during dispensation of 33.5-L water was 1.2±0.1 μg, which only accounts for 2% of the total amount of extractable BPA.
authors.affiliation: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD 20993, USA.
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Choi
authors.forename: Seungil
authors.initials: S
authors.lastname: Cho
authors.forename: Christina
authors.initials: C
authors.lastname: Lee
authors.forename: Hoan My-Do
authors.initials: HM
authors.lastname: Luu
authors.forename: Ji
authors.initials: J
authors.lastname: Guo
mesh_terms: D001559:Benzhydryl Compounds; D002853:Chromatography, Liquid; D005374:Filtration; D013058:Mass Spectrometry; D010636:Phenols / Q000032:analysis*; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction; D013450:Sulfones / Q000737:chemistry*; D014867:Water / Q000737:chemistry*; D018508:Water Purification; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; D011108:Polymers; D013450:Sulfones; D014867:Water; C017662:polysulfone P 1700; C006780:bisphenol A; D000098826:Bisphenol A Compounds