title: The acyl homoserine lactone receptor, SdiA, of Escherichia coli and Salmonella enterica serovar Typhimurium does not respond to indole.
abstract: In this study, we tested the hypothesis that the SdiA proteins of Escherichia coli and Salmonella enterica serovar Typhimurium respond to indole. While indole was found to have effects on gene expression and biofilm formation, these effects were not sdiA dependent. However, high concentrations of indole did inhibit N-acyl-l-homoserine lactone (AHL) sensing by SdiA. We conclude that SdiA does not respond to indole but indole can inhibit SdiA activity in E. coli and Salmonella.
authors.affiliation: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Anice
authors.initials: A
authors.lastname: Sabag-Daigle
authors.forename: Jitesh A
authors.initials: JA
authors.lastname: Soares
authors.forename: Jenée N
authors.initials: JN
authors.lastname: Smith
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Elmasry
authors.forename: Brian M M
authors.initials: BM
authors.lastname: Ahmer
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018441:Biofilms / Q000187:drug effects*; D004926:Escherichia coli / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D053038:Quorum Sensing / Q000235:genetics / Q000502:physiology*; D012486:Salmonella typhimurium / Q000378:metabolism*; D015534:Trans-Activators / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D054742:Acyl-Butyrolactones; D001426:Bacterial Proteins; D007211:Indoles; C097686:SdiA protein, bacteria; D015534:Trans-Activators; C030374:indole