title: A case of bilateral, acquired, and acute dysfunction of short-wavelength-sensitive cone systems.
abstract: To report a case of bilateral, acquired, and acute dysfunction of short-wavelength-sensitive (SWS) cone systems. The case was a healthy 39-year-old man. He noticed sudden onset of bilateral abnormal color vision. Ophthalmic examinations revealed normal fundi in both eyes. Farnsworth panel D-15 test and Farnsworth-Munsell 100-hue test showed tritanopia. White-on-white static perimetry showed no abnormality; however, blue-on-yellow static perimetry detected remarkably reduced sensitivity at the lower visual field in both eyes. ISCEV-standard full-field electroretinograms (ERGs) were normal; however, blue-on-yellow ERGs showed reduced amplitude of b-wave that was derived from SWS cone systems in both eyes. He was observed for 1 year, and no improvement in color vision was found during the observation. This is a unique case which showed bilateral, acquired, and acute dysfunction of SWS cone systems. The cause of the acquired tritanopia remains to be known.
authors.affiliation: Department of Ophthalmology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. kazuki@med.kindai.ac.jp
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kuniyoshi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sakuramoto
authors.forename: Akira
authors.initials: A
authors.lastname: Nakao
authors.forename: Sonoko
authors.initials: S
authors.lastname: Takada
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shimomura
mesh_terms: D000208:Acute Disease; D000328:Adult; D003119:Color Perception Tests; D003117:Color Vision Defects / Q000175:diagnosis* / Q000378:metabolism; D055358:Cone Opsins / Q000378:metabolism*; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000378:metabolism; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
chemical_list: D055358:Cone Opsins; D007208:Indocyanine Green