title: Arsenic in drinking water and acute coronary syndrome in Zrenjanin municipality, Serbia.
abstract: BACKGROUND
  Arsenic is constantly present in drinking water supply systems of Zrenjanin municipality across decades. It presents a great public health problem in Serbia, but its relationship with acute coronary syndrome (ACS) has not been studied previously.
  
  
  OBJECTIVE
  The aims of this study were to assess the incidence of ACS in two areas from Zrenjanin municipality consuming different levels of arsenic in drinking water, and to explore the association between arsenic exposure and the probability of fatal outcome of ACS.
  
  
  METHODS
  The research was a registry-based ecological study of two populations consuming water with different arsenic levels, based on current guidelines (10 μg/L). Median arsenic in the area above national standard was 80 μg/L; median arsenic in the other area was 1 μg/L. Newly diagnosed cases of ACS were obtained from the National Registry for Acute Coronary Syndrome from 2006 to 2010.
  
  
  RESULTS
  The two populations were comparable by age, gender, and prevalence of risk factors for ACS. Standardized incidence rates (SIR) of ACS were higher for people consuming arsenic above standard (average five-year SIR was 237.00 per 100.000; 95% CI=214.93-260.74), in comparison to people consuming arsenic within limits (average SIR=124.40 per 100.000; 95% CI=96.00-158.56). Exposure to arsenic above limits was insignificantly associated with fatal outcome of ACS for the whole population, men and women.
  
  
  CONCLUSIONS
  Consumption of arsenic above national standards was associated with higher risk for the occurrence of acute coronary syndrome and with insignificantly higher probability of fatal outcome of ACS in Zrenjanin municipality.
authors.affiliation: Institute of Public Health of Serbia "Dr Milan Jovanović Batut", Dr Subotića 5, Belgrade, Serbia. dragana_jovanovic@batut.org.rs
authors.forename: Dragana D
authors.initials: DD
authors.lastname: Jovanović
authors.forename: Katarina
authors.initials: K
authors.lastname: Paunović
authors.forename: Dragan D
authors.initials: DD
authors.lastname: Manojlović
authors.forename: Branko
authors.initials: B
authors.lastname: Jakovljević
authors.forename: Zorica
authors.initials: Z
authors.lastname: Rasic-Milutinović
authors.forename: Biljana P
authors.initials: BP
authors.lastname: Dojcinović
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced / Q000453:epidemiology*; D001151:Arsenic / Q000009:adverse effects* / Q000032:analysis*; D060766:Drinking Water / Q000032:analysis*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D055771:Serbia / Q000453:epidemiology; D013054:Spectrophotometry, Atomic; D014505:Urban Population; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic