title: Hemophagocytic lymphohistiocytosis in a patient with angioimmunoblastic lymphoma: a case report and review of the literature.
abstract: Hemophagocytic lymphohistiocytosis is a rare disorder characterized by a proliferation of phagocytic histiocytes in hematopoietic organs. It is accompanied by systemic manifestations and frequently has an abrupt onset with a fulminant clinical course and high mortality. Awareness of this condition is important since early diagnosis and initiation of treatment is critical for a successful outcome. The authors report a patient with hemophagocytic lymphohistiocytosis associated with angioimmunoblastic lymphoma, describe the clinical and histological features of hemophagocytic lymphohistiocytosis, and review the literature on this condition.
authors.affiliation: University Hospital Coventry and Warwickshire NHS Trust, Walsgrave, Coventry, UK.
authors.forename: Josefa E O
authors.initials: JE
authors.lastname: Vella
authors.forename: Hesham
authors.initials: H
authors.lastname: El-Daly
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D049109:Cell Proliferation; D017809:Fatal Outcome; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure; D010587:Phagocytosis
chemical_list: D014408:Biomarkers, Tumor