title: A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
abstract: Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Doria-Rose
authors.forename: Ivelin
authors.initials: I
authors.lastname: Georgiev
authors.forename: Sijy
authors.initials: S
authors.lastname: O'Dell
authors.forename: Gwo-Yu
authors.initials: GY
authors.lastname: Chuang
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Staupe
authors.forename: Jason S
authors.initials: JS
authors.lastname: McLellan
authors.forename: Jason
authors.initials: J
authors.lastname: Gorman
authors.forename: Marie
authors.initials: M
authors.lastname: Pancera
authors.forename: Mattia
authors.initials: M
authors.lastname: Bonsignori
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Burton
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Koff
authors.forename: Peter D
authors.initials: PD
authors.lastname: Kwong
authors.forename: John R
authors.initials: JR
authors.lastname: Mascola
mesh_terms: D000595:Amino Acid Sequence; D057134:Antibodies, Neutralizing / Q000737:chemistry* / Q000276:immunology; D015483:HIV Antibodies / Q000737:chemistry* / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000276:immunology; D015497:HIV-1 / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; C514793:gp120 protein, Human immunodeficiency virus 1