title: [Central neuropsychiatric involvement in systemic lupus erythematosus].
abstract: About one third of patients with systemic lupus erythematosus (SLE) will present neurological or psychiatric symptoms in the course of the disease. Before attributing neuro-psychiatric illness to SLE, other causes have to be excluded, such as infections and treatment-related toxicity. Some manifestations of neuropsychiatric SLE (NPSLE) reflect active systemic disease, while other arise from chronic damage and may occur during apparent remission. Many clinical pictures are associated with antibodies, such as those targeting phospholipids, N-methyl-D-aspartate-receptor and anti-ribosomal P protein. This review discusses clinical manifestations and pathogenesis of central NPSLE, with a focus on the principal antibodies associated and other diagnostic tools at hand.
authors.affiliation: Service d'immunologie clinique et d'allergologie, HUG, 1211 Genève 14.
authors.forename: S
authors.initials: S
authors.lastname: Madrane
authors.forename: C
authors.initials: C
authors.lastname: Ribi
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D003072:Cognition Disorders / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications*; D009422:Nervous System Diseases / Q000209:etiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D012269:Ribosomal Proteins / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate; D012269:Ribosomal Proteins