title: [Bronchoscopic treatment of emphysema].
abstract: Bronchoscopic techniques for the management of emphysema have evolved from the success of surgical treatment. Lung volume reduction surgery (LVRS) involves the removal of 20% to 30% of each lung and targets the most emphysematous segments. Patients with heterogeneous upper lobe emphysema and a low baseline exercise capacity have been identified as a subgroup within COPD in whom mortality benefits can even be achieved, along with improvements in exercise capacity and quality of life. Increased short-term mortality of approximately 5% and postoperative morbidity are the main limitations of LVRS. The extremely restrictive selection criteria for LVRS coupled with the relatively high mortality/morbidity have been the impetus for developing less invasive endoscopic modalities. Bronchoscopic lung volume reduction (BLVR) researchers have pursued various approaches using a range of modalities, such as blockers, stents, valves, sealants, and implants. BLVR appears to be safer than LVRS in terms of mortality and morbidity. This safety profile presents an attractive alternative for patients with COPD who are fragile physiologically because of the severity of their lung disease and the presence of co-morbid illnesses. The current report aims to describe the various minimally invasive modalities available for the treatment of emphysema.
authors.affiliation: The Pulmonary Institute Rabin Medical Center, Petah Tikva, Israel and The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Oren
authors.initials: O
authors.lastname: Fruchter
authors.forename: Mordechai R
authors.initials: MR
authors.lastname: Kramer
mesh_terms: D001999:Bronchoscopy / Q000009:adverse effects / Q000379:methods*; D004646:Emphysema / Q000503:physiopathology / Q000601:surgery*; D017079:Exercise Tolerance; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects / Q000379:methods; D011013:Pneumonectomy / Q000009:adverse effects / Q000379:methods*; D011788:Quality of Life