title: Prevalence of human papillomavirus types in cervical lesions from women in rural Western India.
abstract: Cervical cancer is the most common cancer among women in many areas of India which contributes for a fifth of the global burden of disease. Persistent infection with one of the high-risk human papillomaviruses (HPV) has been established as the cause for cervical cancer and the documentation of the prevalence of HPV types in cervical cancer in different regions of India is useful for a prevention program combining both screening and vaccination. In this study, the HPV type distribution and the frequency of p16(INK4a) immunoexpression have been determined in 125 cases of inflammatory lesions or grade 1 cervical intraepithelial neoplasia, 74 cases of grade 2, 72 cases of grade 3, and 113 cervical cancer cases diagnosed among women from rural Solapur and Osmanabad districts, Maharashtra. The overall prevalence of high-risk HPV was 37.6% in inflammatory lesions or grade 1 cervical intraepithelial neoplasia, 63.5% in grade 2, 97.2% in grade 3 and 92% in cervical cancer cases. HPV 16 and HPV 18 were detected in 80.6% of grade 3 cervical intraepithelial neoplasia and 86.5% of cervical cancer cases. 94.7% of the cervical cancer and 84.4% of the high grade lesions with a strong and full thickness staining for p16(INK4a) were positive for HPV infection; p16(INK4a) immunoexpression increased with worsening grade of cervical intraepithelial neoplasia. The HPV genotyping data showing a high HPV 16 and 18 prevalence in cancer specimens indicate that prophylactic HPV 16/18 vaccination would have a significant impact on the prevention of cervical cancer in India.
authors.affiliation: Tata Memorial Center, Tata Memorial Hospital & Cancer Research Institute, Mumbai, India.
authors.forename: Kedar
authors.initials: K
authors.lastname: Deodhar
authors.forename: Tarik
authors.initials: T
authors.lastname: Gheit
authors.forename: Salvatore
authors.initials: S
authors.lastname: Vaccarella
authors.forename: Christine Carreira
authors.initials: CC
authors.lastname: Romao
authors.forename: Vanessa
authors.initials: V
authors.lastname: Tenet
authors.forename: Bhagwan M
authors.initials: BM
authors.lastname: Nene
authors.forename: Kasturi
authors.initials: K
authors.lastname: Jayant
authors.forename: Rohini
authors.initials: R
authors.lastname: Kelkar
authors.forename: Sylla G
authors.initials: SG
authors.lastname: Malvi
authors.forename: Bakary S
authors.initials: BS
authors.lastname: Sylla
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Jose
authors.initials: J
authors.lastname: Jeronimo
authors.forename: Surendra
authors.initials: S
authors.lastname: Shastri
authors.forename: Rengaswamy
authors.initials: R
authors.lastname: Sankaranarayanan
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D012424:Rural Population; D002583:Uterine Cervical Neoplasms / Q000821:virology*