title: T cell acute lymphoblastic leukaemia presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and cerebrospinal fluid studies.
abstract: Leptomeningeal disease presenting with neurological dysfunction is not uncommon in leukaemia. However, it is often accompanied by abnormalities in cerebrospinal fluid (CSF) studies and/or neuroradiography. Here, the authors describe a case of a young patient presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and CSF studies, who was subsequently diagnosed to have T cell acute lymphoblastic leukaemia (T-ALL). This case highlights that neurological manifestations can be the initial presenting feature of T-ALL and can occur suddenly despite normal neuroradiography and initial CSF studies.
authors.affiliation: Department Of Medicine, Staten Island University Hospital, Staten Island, New York, USA.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
authors.forename: Muniba
authors.initials: M
authors.lastname: Naqi
authors.forename: Rajiv
authors.initials: R
authors.lastname: Bartaula
authors.forename: Srujitha
authors.initials: S
authors.lastname: Murukutla
authors.forename: Sulagna
authors.initials: S
authors.lastname: Misra
authors.forename: Muhammad
authors.initials: M
authors.lastname: Popalzai
authors.forename: Kavitha
authors.initials: K
authors.lastname: Paramanathan
authors.forename: Qun
authors.initials: Q
authors.lastname: Dai
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009485:Neuroradiography; D015840:Oculomotor Nerve Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy