title: Ondansetron pretreatment reduces pain on injection of propofol.
abstract: To assess the effectiveness of ondansetron pretreatment in alleviating propofol injection pain, 135 patients were randomly assigned to one of following three groups. Group 1 who received up to 2 mL pretreatment 50 mg tramadol in the saline, group 2 cases who received up to 2 mL pretreatment 4 mg ondansetron in saline, and group 3 who received up to 2 mL solution saline. A 20 gauge cannula was placed into the largest vein on the dorsum of the hand. Tourniquet was closed to the arm above the cannula and inflates to 70 mmHg, and then drug was injected. After 20 seconds, the tourniquet deflated, and propofol 2mg/kg injected over 10 seconds and pain assessment was made.
  
  
  RESULTS
  Tramadol and ondansetron significantly reduced the incidence and severity of propofol injection pain more than placebo (P=0.001). The efficacy of ondansetron in alleviating the pain on injection of propofol was no different from tramadol (P=0.330). Ondansetron pretreatment may be used to reduce the incidence of pain on injection of propofol, an advantage added to the useful prevention of postoperative nausea and vomiting.
authors.affiliation: Department of Anesthesiology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Zahedi
authors.forename: Anahid
authors.initials: A
authors.lastname: Maleki
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Rostami
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D000704:Analysis of Variance; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006225:Hand / Q000098:blood supply*; D006801:Humans; D007275:Injections, Intravenous; D007492:Iran; D008297:Male; D017294:Ondansetron / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D011237:Predictive Value of Tests; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D012720:Severity of Illness Index; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D058831:Serotonin 5-HT3 Receptor Antagonists; D014147:Tramadol; D017294:Ondansetron; D015742:Propofol