title: The effects of ellagic acid on the liver and remote organs' oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in rats.
abstract: BACKGROUND
  We aimed to investigate the possible protective effects of ellagic acid (EA) on the liver and remote organs against the hepatic ischemia-reperfusion injury.
  
  
  METHODS
  Forty Wistar-Albino rats were divided into four groups each containing 10 rats. Group I with laparotomy only, Group II with laparatomy and ellagic acid application, Group III with hepatic ischemia-reperfusion and Group IV with hepatic ischemia-reperfusion and ellagic acid application. Hepatic ischemia was induced by pringle's manoeuvre for 30 minutes followed by 30 minutes reperfusion period. After induction of ischemia, EA was applied via oral gavage at a dose of 85 mg/kg. Blood samples were taken from the animals for biochemical analysis at 60th minute of the experiment in all groups. Simultaneously, liver, lung and kidney tissues were sampled for biochemical analyses and histopathological examinations.
  
  
  RESULTS
  The administration of EA reduced serum malonyldialdehid levels (p<0.05) and liver's oxidative stress index compared with the non-use EA groups (p0.05). The use of EA did not exert significant protective effects against the effects of liver ischemia-reperfusion injury on the kidney and lung.
  
  
  CONCLUSIONS
  In our experiments ellagic acid reduced the liver oxidative stress induced by ischemia-reperfusion injury. However, no significant histological improvement was found with EA. There were no significant protective effects on the remote organ injuries induced by ischemia-reperfusion (Tab. 3, Fig. 7, Ref. 37).
authors.affiliation: Department of Surgery, Dicle University Medical Faculty, Diyarbakur, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kapan
authors.forename: M
authors.initials: M
authors.lastname: Gumus
authors.forename: A
authors.initials: A
authors.lastname: Onder
authors.forename: U
authors.initials: U
authors.lastname: Firat
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Basarali
authors.forename: A
authors.initials: A
authors.lastname: Boyuk
authors.forename: I
authors.initials: I
authors.lastname: Aliosmanoglu
authors.forename: S
authors.initials: S
authors.lastname: Buyukbas
mesh_terms: D000818:Animals; D004610:Ellagic Acid / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D004610:Ellagic Acid; D008315:Malondialdehyde