title: Optical resolution of aromatic alcohols using silica nanoparticles grafted with helicene.
abstract: Optically active silica nanoparticles, with a 70-nm diameter, grafted with (P)-1,12-dimethyl-8-methoxycarbonylbenzo[c]phenanthrene-5-carboxyamide were synthesized, and their use in the kinetic resolution of aromatic alcohols was examined. Up to 61% ee for (S)-2,2-dimethyl-1-phenyl-1-propanol was obtained by a preferential precipitation of aggregates formed with (P)-nanoparticles.
authors.affiliation: Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Sendai 980-8578, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Ichinose
authors.forename: Masamichi
authors.initials: M
authors.lastname: Miyagawa
authors.forename: Zengjian
authors.initials: Z
authors.lastname: An
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D011083:Polycyclic Compounds; C031660:helicenes; D012822:Silicon Dioxide