title: Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake.
abstract: OBJECTIVE
  To investigate the role of N-Methyl-D-aspartic acid (NMDA)-type glutamate receptors in the central nucleus of the amygdale (CeA) in food and water intake.
  
  
  METHODS
  Male Sprague-Dawley rats with stainless steel cannulae implanted unilaterally into the CeA were used. The prototypic NMDA receptor agonist NMDA, or the selective NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5) was microinjected into the CeA of satiated and euhydrated rats.
  
  
  RESULTS
  Intra-CeA injection of 8.50, 17.00, or 34.00 nmol NMDA did not alter food intake but significantly increased water intake 0-1 h after the injection (F(3,32)=3.191, P=0.037) independent of food intake. Without affecting the food intake, injection of 6.34, 12.70, or 25.40 nmol D-AP-5 into the CeA significantly decreased water intake 0-1 h after the injection (F(3,28)=3.118, P=0.042) independent of food intake.
  
  
  CONCLUSIONS
  NMDA receptors in the CeA may participate in the control of water intake rather than food intake.
authors.affiliation: Department of Physiology and Pathophysiology, Xi'an Jiaotong University College of Medicine, Xi'an, China. junbaoyan@gmail.com
authors.forename: Junbao
authors.initials: J
authors.lastname: Yan
authors.forename: Jianqun
authors.initials: J
authors.lastname: Yan
authors.forename: Jinrong
authors.initials: J
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.forename: Huiling
authors.initials: H
authors.lastname: Sun
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Shiru
authors.initials: S
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Song
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wei
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000037:antagonists & inhibitors
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate