title: Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury.
abstract: BACKGROUND
  Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.
  
  
  METHODS
  Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O(2)), hyperoxia+NSO and control (21% O(2)). Pups in the hyperoxia+NSO group were administered intraperitoneal NSO at a dose of 4ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed.
  
  
  RESULTS
  In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia+NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia+NSO group (P<.05).
  
  
  CONCLUSIONS
  NSO significantly reduced the severity of lung damage due to hyperoxia.
authors.affiliation: Department of Neonatology, GATA Military School of Medicine, Ankara, Turquía. ctayman22@gmail.com
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Tayman
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Ilker Mustafa
authors.initials: IM
authors.lastname: Kafa
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Alparslan
authors.initials: A
authors.lastname: Tonbul
authors.forename: Sema
authors.initials: S
authors.lastname: Uysal
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: S Umit
authors.initials: SU
authors.lastname: Sarici
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005979:Glutathione Peroxidase / Q000032:analysis; D018496:Hyperoxia / Q000150:complications*; D007249:Inflammation; D007274:Injections, Intraperitoneal; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008315:Malondialdehyde / Q000032:analysis; D031881:Nigella sativa / Q000737:chemistry*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D009195:Peroxidase / Q000032:analysis; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013482:Superoxide Dismutase / Q000032:analysis; D029974:Carum
chemical_list: D010938:Plant Oils; D008315:Malondialdehyde; C104525:caraway oil; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase