title: Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil.
abstract: The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the oral delivery of frankincense and myrrh essential oils (FMO). Aqueous dispersions of SLNs were successfully prepared by a high-pressure homogenization method using Compritol 888 ATO as the solid lipid and soybean lecithin and Tween 80 as the surfactants. The properties of the SLNs such as particle size, zeta potential (ZP), and drug encapsulation efficiency (EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM). The crystallinity of the formulation was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). In addition, drug evaporation release and antitumor activity were also studied. Round SLNs with a mean size of 113.3 ± 3.6 nm, a ZP of -16.8 ± 0.4 mV, and an EE of 80.60% ± 1.11% were obtained. DSC and XRD measurements revealed that less ordered structures were formed in the inner cores of the SLN particles. Evaporation loss of the active components in FMO could be reduced in the SLNs. Furthermore, the SLN formulation increased the antitumor efficacy of FMO in H22-bearing Kunming mice. Hence, the presented SLNs can be used as drug carriers for hydrophobic oil drugs extracted from traditional Chinese medicines.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Ji-Hui
authors.initials: JH
authors.lastname: Zhao
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Yong-Tai
authors.initials: YT
authors.lastname: Zhang
authors.forename: Nian-Ping
authors.initials: NP
authors.lastname: Feng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D029743:Boswellia / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry; D008297:Male; D051379:Mice; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry*; D013729:Terpenes / Q000008:administration & dosage*; D013816:Thermodynamics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D008055:Lipids; D009822:Oils, Volatile; D010938:Plant Oils; D013729:Terpenes; C014119:myrrh oil