title: Serum levels of adipocyte fatty acid-binding protein are decreased in chronic pancreatitis.
abstract: OBJECTIVE
  Chronic pancreatitis (CP) is associated with an increased risk for diabetes mellitus and vascular disease. Adipocyte fatty acid-binding protein (AFABP) is a novel adipokine that is independently associated with the metabolic syndrome and cardiovascular disease. In the current study, we investigated serum AFABP levels in CP patients compared with sex- and body mass index-matched controls.
  
  
  METHODS
  Adipocyte fatty acid-binding protein was determined with enzyme-linked immunosorbent assay in control subjects (n = 60) and diabetic as well as nondiabetic CP (n = 60) patients and correlated to clinical and biochemical measures of glucose and lipid metabolism, as well as renal function in both groups.
  
  
  RESULTS
  Median serum AFABP levels were significantly lower in CP patients compared with controls (12.5 vs 20.9 μg/L, P = 0.003). Furthermore, body mass index, sex, and CP independently predicted circulating AFABP. In contrast, no significant difference in circulating AFABP could be demonstrated between diabetic and nondiabetic CP patients.
  
  
  CONCLUSIONS
  Circulating AFABP is paradoxically lower in CP patients and does not depend on pancreatic diabetes. Our data do not support a role of circulating AFABP in metabolic and vascular risk in CP patients.
authors.affiliation: Department of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Selig
authors.forename: Matthias
authors.initials: M
authors.lastname: Reiche
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebert
authors.forename: Doreen
authors.initials: D
authors.lastname: Krehl
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lossner
authors.forename: Barbara
authors.initials: B
authors.lastname: Stach
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.forename: Hans
authors.initials: H
authors.lastname: Bödeker
authors.forename: Volker
authors.initials: V
authors.lastname: Keim
authors.forename: Joachim
authors.initials: J
authors.lastname: Mössner
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000209:etiology / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000502:physiology; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000150:complications / Q000378:metabolism; D012737:Sex Factors; D055815:Young Adult
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D005947:Glucose