title: Chalcone-derived Diels-Alder adducts as NF-κB inhibitors from Morus alba.
abstract: A bioassay-guided phytochemical fractionation of the methanol extract of the Morus alba root barks led to the isolation of two chalcone-derived Diels-Alder adducts (1 and 2). Their structures were elucidated as kuwanon J 2,4,10″-trimethyl ether (1) and kuwanon R (2) by means of spectroscopic methods. Both compounds strongly inhibited nuclear transcription factor.κB activity with the IC₅₀ values of 4.65 and 7.38 μM, respectively.
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam.
authors.forename: Thi Xuan Binh
authors.initials: TX
authors.lastname: Phung
authors.forename: Thi Hong Hanh
authors.initials: TH
authors.lastname: Tran
authors.forename: Thi Thuy Hang
authors.initials: TT
authors.lastname: Dan
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Thanh Huong
authors.initials: TH
authors.lastname: Hoang
authors.forename: Tien Dat
authors.initials: TD
authors.lastname: Nguyen
mesh_terms: D002599:Chalcone / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047188:Chalcones; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D016328:NF-kappa B / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D014744:Vietnam
chemical_list: D047188:Chalcones; D016328:NF-kappa B; C574108:kuwanon J 2,4,10''-trimethyl ether; C574109:kuwanon R; D002599:Chalcone