title: A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells.
abstract: The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-κB-dependent release of TNF-α/IFN-γ. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.
authors.affiliation: Laboratory of Immunotherapy, Department I of Internal Medicine, University Clinic of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
authors.forename: Vijaya Lakshmi
authors.initials: VL
authors.lastname: Simhadri
authors.forename: Hinrich P
authors.initials: HP
authors.lastname: Hansen
authors.forename: Venkateswara R
authors.initials: VR
authors.lastname: Simhadri
authors.forename: Katrin S
authors.initials: KS
authors.lastname: Reiners
authors.forename: Martina
authors.initials: M
authors.lastname: Bessler
authors.forename: Andreas
authors.initials: A
authors.lastname: Engert
authors.forename: Elke Pogge
authors.initials: EP
authors.lastname: von Strandmann
mesh_terms: D053285:CD30 Ligand / Q000096:biosynthesis / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D053285:CD30 Ligand; D017730:Ki-1 Antigen; C505774:TNFSF8 protein, human