title: [The antiviral activity of diphenyl derivatives in different model systems].
abstract: In experiments on two model systems L929/VSV and RF/ HSV-1 in vitro we have studied the antiviral activity of new structural analogues of tilorone--4,4'-bis[2-(diethyl-amino)ethoxy]diphenyl dihydrochloride and 2-methoxy-carbonyl-4-4'-bis[2-(diethylamino)ethoxy]diphenyl dihydrochloride. In experiments the tested substances were administered in preventive and therapeutic schemes. The preventive scheme confirms the existence of a correlation between IFN production under the influence of tested substances and their antiviral activity. It is shown that diphenyls are able to inhibit the development of viral cytopathic effect induced by DNA- and RNA-containing viruses. Diphenyl derivatives are less toxic than tilorone and could be considered as promising substances for further research to develop new antiviral drugs.
authors.forename: O S
authors.initials: OS
authors.lastname: Bogorad-Kobel's'ka
authors.forename: N M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: Z M
authors.initials: ZM
authors.lastname: Olevins'ka
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Spivak
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects* / Q000821:virology; D006561:Herpes Simplex / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D020714:Maximum Tolerated Dose; D051379:Mice; D008954:Models, Biological; D051381:Rats; D013994:Tilorone / Q000494:pharmacology; D054243:Vesicular Stomatitis / Q000188:drug therapy / Q000821:virology; D018116:Vesiculovirus / Q000187:drug effects* / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D001713:Biphenyl Compounds; D013994:Tilorone