title: Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results.
abstract: In 2008, we reported favorable 5-year outcomes of nonmyeloablative allogeneic stem cell transplantation after fludarabine, cyclophosphamide, rituximab (FCR) conditioning for relapsed and chemosensitive follicular lymphoma. However, innovative strategies were still needed to treat patients with chemorefractory disease. We therefore subsequently performed a trial in which (90)Y-ibritumomab tiuxetan (0.4 mCi/kg) was added to the fludarabine, cyclophosphamide conditioning regimen ((90)YFC). Here, we report updated results of the FCR trial and outcomes after (90)YFC. For the FCR group (N = 47), since the last update, one patient developed recurrent disease. With a median follow-up of 107 months (range, 72-142 months), the 11-year overall survival and progression-free survival rates were 78%, and 72%, respectively. For the (90)YFC group (N = 26), more patients had chemorefractory disease than did those in the FCR group (38% and 0%, P < .001). With a median follow-up of 33 months (range,17-94 months), the 3-year progression-free survival rates for patients with chemorefractory and chemosensitive disease were 80% and 87%, respectively (P = .7). The low frequency of relapse observed after a long follow-up interval of 9 years in the FCR group suggests that these patients are cured of their disease. The addition of (90)Y to the conditioning regimen appears to be effective in patients with chemorefractory disease. This trial was registered at www.clinicaltrials.gov as NCT00048737.
authors.affiliation: Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ikhouri@mdanderson.org
authors.forename: Issa F
authors.initials: IF
authors.lastname: Khouri
authors.forename: Rima M
authors.initials: RM
authors.lastname: Saliba
authors.forename: William D
authors.initials: WD
authors.lastname: Erwin
authors.forename: Barry I
authors.initials: BI
authors.lastname: Samuels
authors.forename: Martin
authors.initials: M
authors.lastname: Korbling
authors.forename: L Jeffrey
authors.initials: LJ
authors.lastname: Medeiros
authors.forename: Rosamar
authors.initials: R
authors.lastname: Valverde
authors.forename: Amin M
authors.initials: AM
authors.lastname: Alousi
authors.forename: Paolo
authors.initials: P
authors.lastname: Anderlini
authors.forename: Qaiser
authors.initials: Q
authors.lastname: Bashir
authors.forename: Stefan
authors.initials: S
authors.lastname: Ciurea
authors.forename: Alison M
authors.initials: AM
authors.lastname: Gulbis
authors.forename: Marcos
authors.initials: M
authors.lastname: de Lima
authors.forename: Chitra
authors.initials: C
authors.lastname: Hosing
authors.forename: Partow
authors.initials: P
authors.lastname: Kebriaei
authors.forename: Uday R
authors.initials: UR
authors.lastname: Popat
authors.forename: Nathan
authors.initials: N
authors.lastname: Fowler
authors.forename: Sattva S
authors.initials: SS
authors.lastname: Neelapu
authors.forename: Felipe
authors.initials: F
authors.lastname: Samaniego
authors.forename: Richard E
authors.initials: RE
authors.lastname: Champlin
authors.forename: Homer A
authors.initials: HA
authors.lastname: Macapinlac
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use; D016499:Radioimmunotherapy; D012008:Recurrence; D012074:Remission Induction; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D019653:Myeloablative Agonists; D015021:Yttrium Radioisotopes; C422802:ibritumomab tiuxetan