title: The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis.
abstract: Migration and invasion are fundamental features of metastatic cancer cells. The Golgi apparatus, an organelle involved in posttranslational modification and sorting of proteins, is widely accepted to regulate directional cell migration. In addition, mounting evidence suggests that the Golgi is a hub for different signaling pathways. In this paper we will give an overview on how polarized secretion and microtubule nucleation at the Golgi regulate directional cell migration. We will review different signaling pathways that signal to and from the Golgi. Finally, we will discuss how these signaling pathways regulate the role of the Golgi in cell migration and invasion. We propose that by identifying regulators of the Golgi, we might be able to uncover unappreciated modulators of cell migration. Uncovering the regulatory network that orchestrates cell migration is of fundamental importance for the development of new therapeutic strategies against cancer cell metastasis.
authors.affiliation: Department of Biology, University of Konstanz, Universitätsstrasse 10, Konstanz, Germany.
authors.forename: Valentina
authors.initials: V
authors.lastname: Millarte
authors.forename: Hesso
authors.initials: H
authors.lastname: Farhan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D022101:Microtubule-Organizing Center / Q000502:physiology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D049488:Phosphatidylethanolamine Binding Protein / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000502:physiology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C532354:PAQR3 protein, human; C511482:PEBP1 protein, human; D049488:Phosphatidylethanolamine Binding Protein; D010716:Phosphatidylinositols; D058570:TOR Serine-Threonine Kinases; D018844:Cyclin-Dependent Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020741:rho GTP-Binding Proteins