title: [Molecular-cellular and hormonal mechanisms of induced brain tolerance of extreme factors].
abstract: This review includes results of own studies and literature data on the topical problem of neurobiology and medicine: discovery of the mechanisms of increased brain resistance to extreme exposures. The emphasis is made on the molecular-cellular and hormonal mechanisms of hypoxic preconditioning-induced brain tolerance to injurious hypoxia, psychoemotional and traumatic stress. A role of basic hormonal and intracellular cascade pro-adaptive processes mediating the neuroprotective action of hypoxic preconditioning is reviewed. A dynamics of the mechanisms of development of induced susceptible brain areas (hippocampus, neocortex) tolerance which includes phases of induction, transformation and expression, is presented. New data on preconditioning-induced cross-tolerance providing increased brain resistance not only to hypoxia but also to other stresses are reported. For the first time neuroprotective effects of hypoxic postconditioning are described.
authors.forename: M O
authors.initials: MO
authors.lastname: Samoĭlov
authors.forename: E A
authors.initials: EA
authors.lastname: Rybnikova
mesh_terms: D000222:Adaptation, Physiological; D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology*; D019194:Ischemic Preconditioning; D009446:Neurobiology
chemical_list: D000305:Adrenal Cortex Hormones