title: Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery.
abstract: In this study, the authors constructed a novel PLGA [poly(D,L-lactic-co-glycolic acid)]-based polymeric nanocarrier co-encapsulated with doxorubicin (DOX) and magnetic Fe(3)O(4) nanoparticles (MNPs) using a single emulsion evaporation method. The DOX-MNPs showed high entrapment efficiency, and they supported a sustained and steady release of DOX. Moreover, the drug release was pH sensitive, with a faster release rate in an acidic environment than in a neutral environment. In vitro, the DOX-MNPs were easily internalized into murine Lewis lung carcinoma cells and they induced apoptosis. In vivo, the DOX-MNPs showed higher antitumor activity than free DOX solution. Furthermore, the antitumor activity of the DOX-MNPs was higher with than without an external magnetic field; they were also associated with smaller tumor volume and a lower metastases incidence rate. This work may provide a new modality for developing an effective drug delivery system.
authors.affiliation: Institute of Orthopedics, General Hospital of the Chinese People's Liberation Army, Beijing, People's Republic of China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Jia
authors.forename: Mei
authors.initials: M
authors.lastname: Yuan
authors.forename: Huidong
authors.initials: H
authors.lastname: Yuan
authors.forename: Xinglu
authors.initials: X
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Sui
authors.forename: Xuemei
authors.initials: X
authors.lastname: Cui
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
authors.forename: Jiang
authors.initials: J
authors.lastname: Peng
authors.forename: Jiying
authors.initials: J
authors.lastname: Chen
authors.forename: Shibi
authors.initials: S
authors.lastname: Lu
authors.forename: Wenjing
authors.initials: W
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Quanyi
authors.initials: Q
authors.lastname: Guo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D019344:Lactic Acid / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D050997:Nanomedicine; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin