title: An earring for the double helix: assembly of topological links comprising duplex DNA and a circular oligodeoxynucleotide.
abstract: Abstract   Novel DNA nanostructures, locked pseudorotaxane and locked catenane were assembled through topological linkage of a double-stranded target to a circular oligodeoxyribonucleotide (cODN)(+). The formation of these supramolecular complexes occurs with remarkable sequence specificity and is accomplished via local opening of duplex DNA by a pair of homopyrimidine bis-PNAs. The obtained cODN label, resembling an earring, forms a true topological link with the linear or closed circular (cc) target DNA and occupies a fixed position along the double helix. The PNA directed assembly described here introduces PNA oligomers into the repertoire of DNA nanotechnological tools.
authors.affiliation: a      Center for Advanced Biotechnology, Department of Biomedical Engineering   ,  Boston University   ,  36 Cummington St. ,    Boston   ,    MA   ,    02215.
authors.forename: H
authors.initials: H
authors.lastname: Kuhn
authors.forename: V V
authors.initials: VV
authors.lastname: Demidov
authors.forename: M D
authors.initials: MD
authors.lastname: Frank-Kamenetskii
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D020135:Peptide Nucleic Acids
chemical_list: D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA