title: Inhibition and avoidance of mRNA degradation by RNA viruses.
abstract: The cellular mRNA decay machinery plays a major role in regulating the quality and quantity of gene expression in cells. This machinery involves multiple enzymes and pathways that converge to promote the exonucleolytic decay of mRNAs. The transcripts made by RNA viruses are susceptible to degradation by this machinery and, in fact, can be actively targeted. Thus, to maintain gene expression and replication, RNA viruses have evolved a number of strategies to avoid and/or inactivate aspects of the cellular mRNA decay machinery. Recent work uncovering the mechanisms used by RNA viruses to maintain the stability of their transcripts is described below.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Moon
authors.forename: Michael D
authors.initials: MD
authors.lastname: Barnhart
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wilusz
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D005095:Exoribonucleases / Q000378:metabolism; D006801:Humans; D020871:RNA Stability; D012328:RNA Viruses / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D005095:Exoribonucleases; D012333:RNA, Messenger; D012367:RNA, Viral