title: Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: a pre-/post-study.
abstract: Chronic intrarenal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygen level-dependent magnetic resonance imaging was used to determine intrarenal oxygen status pre- and post-angiotensin receptor blockade (olmesartan) treatment in normal subjects, diabetic chronic kidney disease (CKD) patients and non-diabetic CKD patients. The mean R2*, which represents intrarenal oxygenation, was significantly lower in the control group than in the CKD group (12.42 ± 0.53 /s vs 18.89 ± 3.15 /s, P < 0.01), indicating the presence of intrarenal hypoxia in the CKD patients. The olmesartan treatment induced a 16.2 ± 7.7% decrement of the mean R2* in CKD patients, suggesting that this drug had an intrarenal hypoxia ameliorating effect.
authors.affiliation: Renal Unit, Department of Medicine, Lerdsin General Hospital, Bangkok, Thailand. kmanotham@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Manotham
authors.forename: B
authors.initials: B
authors.lastname: Ongvilawan
authors.forename: P
authors.initials: P
authors.lastname: Urusopone
authors.forename: S
authors.initials: S
authors.lastname: Chetsurakarn
authors.forename: J
authors.initials: J
authors.lastname: Tanamai
authors.forename: P
authors.initials: P
authors.lastname: Limkuansuwan
authors.forename: K
authors.initials: K
authors.lastname: Tungsanga
authors.forename: S
authors.initials: S
authors.lastname: Eiam-Ong
mesh_terms: D000328:Adult; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan; D010100:Oxygen