title: Implicit memory in Korsakoff's syndrome: a review of procedural learning and priming studies.
abstract: Korsakoff's syndrome (KS) is characterized by dense anterograde amnesia resulting from damage to the diencephalon region, typically resulting from chronic alcohol abuse and thiamine deficiency. This review assesses the integrity of the implicit memory system in KS, focusing on studies of procedural learning and priming. KS patients are impaired on several measures of procedural memory, most likely due to impairment in cognitive functions associated with alcohol-related neural damage outside of the diencephalon. The pattern of performance on tasks of implicit priming suggests reliance on a residual, non-flexible memory operating more or less in an automatic fashion. Our review concludes that whether measures of implicit memory reveal intact or impaired performance in individuals with KS depends heavily on specific task parameters and demands, including timing between stimuli, the specific nature of the stimuli used in a task, and the integrity of supportive cognitive functions necessary for performance.
authors.affiliation: Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of Medicine, Boston, MA, USA. smhayes@bu.edu
authors.forename: Scott M
authors.initials: SM
authors.lastname: Hayes
authors.forename: Catherine B
authors.initials: CB
authors.lastname: Fortier
authors.forename: Andrea
authors.initials: A
authors.lastname: Levine
authors.forename: William P
authors.initials: WP
authors.lastname: Milberg
authors.forename: Regina
authors.initials: R
authors.lastname: McGlinchey
mesh_terms: D000437:Alcoholism / Q000503:physiopathology; D020324:Amnesia, Anterograde / Q000209:etiology; D000818:Animals; D003071:Cognition / Q000502:physiology; D006801:Humans; D020915:Korsakoff Syndrome / Q000503:physiopathology*; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology