title: Plasma concentrations of posaconazole administered via nasogastric tube in patients in a surgical intensive care unit.
abstract: Abdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients, possibly due to poor absorption.
authors.affiliation: Pharmacy Department, University Hospital of Heidelberg, Heidelberg, Germany. dominic.stoerzinger@med.uni-heidelberg.de
authors.forename: Dominic
authors.initials: D
authors.lastname: Störzinger
authors.forename: Stephan
authors.initials: S
authors.lastname: Borghorst
authors.forename: Stefan
authors.initials: S
authors.lastname: Hofer
authors.forename: Cornelius J
authors.initials: CJ
authors.lastname: Busch
authors.forename: Christoph
authors.initials: C
authors.lastname: Lichtenstern
authors.forename: Georg
authors.initials: G
authors.lastname: Hempel
authors.forename: Markus A
authors.initials: MA
authors.lastname: Weigand
authors.forename: Torsten
authors.initials: T
authors.lastname: Hoppe-Tichy
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003422:Critical Care; D005260:Female; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole