title: Ambulatory blood pressure monitoring in Chinese children with obstructive sleep apnea/hypopnea syndrome.
abstract: OBJECTIVE
  Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common sleep problem. The aim of this study is to investigate the association between OSAHS and blood pressure (BP) in snoring children.
  
  
  METHODS
  Snoring children were recruited from January 2009 to December 2010. Clinical history was taken accompanied by a physical examination and polysomnography were performed. A child with an apnea/hypopnea index (AHI) greater than 5 hr(-1) or obstructive apnea index (OAI) greater than 1 hr(-1) was diagnosed as having OSAHS. Ambulatory BP monitoring was performed for each child. BP load, BP index and nocturnal BP dipping were calculated for each child.
  
  
  RESULTS
  One hundred forty-five children with snoring were recruited and 107 of them were diagnosed with OSAHS. There were no differences between those with or without OSA in age or gender distribution. The OSAHS children had higher mean nighttime systolic and diastolic BP, increased BP load, and decreased nocturnal BP dipping compared to the non-OSAHS children (SBP: P = 0.03, DBP: P < 0.001, BP load: P = 0.001, SBP dipping: P = 0.03, DBP dipping: P = 0.04). Multiple regression analysis showed that mean nighttime systolic BP was related to age, obesity, and oxygen desaturation index (ODI) (P = 0.04, 0.03, and 0.02 respectively), while mean nighttime diastolic BP was related to obesity and ODI (P = 0.03 and 0.04, respectively).
  
  
  CONCLUSIONS
  OSAHS children had a higher nocturnal BP than non-OSAHS children and dysregulation of BP control reflected by decreased nocturnal BP dipping. Frequency of oxygen desaturation, apneas, and obesity were related to BP.
authors.affiliation: Respiratory Department, Beijing Children's Hospital affiliated to Capital Medical University, Xicheng District, Beijing, China.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Xu
authors.forename: Bei
authors.initials: B
authors.lastname: Li
authors.forename: Kunling
authors.initials: K
authors.lastname: Shen
mesh_terms: D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D017286:Polysomnography; D012044:Regression Analysis; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology