title: Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.
abstract: Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.
authors.affiliation: Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington, LE12 5RD, UK.
authors.forename: Ali
authors.initials: A
authors.lastname: Mobasheri
authors.affiliation: Bone and Cartilage Research Unit, Institute of Pathology, University of Liège, Sart-Tilman, 4000 Liège, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Henrotin
authors.affiliation: Department of Biological Chemistry and Nutrition, University of Hohenheim, D-70593 Stuttgart, Germany.
authors.forename: Hans-Konrad
authors.initials: HK
authors.lastname: Biesalski
authors.affiliation: Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shakibaei
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology; D019902:Chondrocytes / Q000378:metabolism; D003474:Curcumin / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D053583:Interleukin-1beta / Q000276:immunology; D007596:Joints / Q000473:pathology*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology; D064209:Phytochemicals / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; C508585:IL1B protein, human; D053583:Interleukin-1beta; D064209:Phytochemicals; C498143:RELA protein, human; D013267:Stilbenes; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D003474:Curcumin; D000077185:Resveratrol