title: Prevalence of limb muscle dysfunction in patients with chronic obstructive pulmonary disease admitted to a pulmonary rehabilitation centre.
abstract: OBJECTIVE
  Assessment of needle electromyography (nEMG) may complement previous data on limb muscle dysfunction (LMD) in patients with chronic obstructive pulmonary disease (COPD). We attempted to quantify the prevalence of LMD and assess its impact on clinical outcomes in patients admitted to a rehabilitation programme.
  
  
  METHODS
  One hundred and thirty-two clinically stable patients were consecutively enrolled. They underwent spirometry and the following primary outcomes were evaluated: St. George respiratory questionnaire (SGRQ), functional independence measure (FIM) questionnaire and a 6-min walking test (6MWT). One hundred and fourteen patients underwent nEMG. The frequency of LMD was related to COPD stage and chronic dyspnoea.
  
  
  RESULTS
  nEMG detected myopathic signs in 36.8% of the patients. LMD was found even in early stages of COPD. FIM and 6MWT were significantly lower, and SGRQ tended to be higher at each COPD stage in patients with LMD. However, the 6MWT rate of decay across the COPD stages was similar in patients with and without LMD.
  
  
  CONCLUSIONS
  LMD might not be restricted to patients with severe airway obstruction and regardless of COPD stage, contributes to functional limitation of these patients.
  
  
  CONCLUSIONS
  The putative role of LMD in motor limitations indicates the need to assess it early onto better organise a specific training programme as part of general pulmonary rehabilitation in COPD patients.
authors.affiliation: Respiratory Rehabilitation, Fond. Don C. Gnocchi ONLUS, IRCCS, Florence, Italy. riccadoc@hotmail.com
authors.forename: Riccardo
authors.initials: R
authors.lastname: Carrai
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scano
authors.forename: Francesco
authors.initials: F
authors.lastname: Gigliotti
authors.forename: Isabella
authors.initials: I
authors.lastname: Romagnoli
authors.forename: Barbara
authors.initials: B
authors.lastname: Lanini
authors.forename: Claudia
authors.initials: C
authors.lastname: Coli
authors.forename: Antonello
authors.initials: A
authors.lastname: Grippo
mesh_terms: D000368:Aged; D015897:Comorbidity; D004576:Electromyography; D005121:Extremities / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000503:physiopathology / Q000534:rehabilitation; D012047:Rehabilitation Centers / Q000706:statistics & numerical data*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016138:Walking / Q000502:physiology