title: Transcriptional control of innate lymphocyte fate decisions.
abstract: It has recently emerged that innate lymphocytes are more diverse than previously appreciated. In addition to natural killer cells, various subsets of innate lymphoid cells are now being characterized. It has become apparent that the transcriptional programs underlying lineage specification and cell fate decisions of innate lymphocytes strikingly resemble those of T cell subsets, suggesting that such transcriptional circuitry was already pre-formed in the evolutionary older innate immune system. Here, we will review recent advances in our understanding of the core transcriptional programs driving development and cell fate decisions of innate lymphocytes. We will also discuss whether these transcriptional programs are stable or flexible, thereby allowing for plastic adaptation of immune responses.
authors.affiliation: IMMH, Institute of Medical Microbiology & Hygiene, University of Freiburg Medical Centre, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.
authors.forename: Christoph S N
authors.initials: CS
authors.lastname: Klose
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoyler
authors.forename: Elina A
authors.initials: EA
authors.lastname: Kiss
authors.forename: Yakup
authors.initials: Y
authors.lastname: Tanriver
authors.forename: Andreas
authors.initials: A
authors.lastname: Diefenbach
mesh_terms: D000818:Animals; D019070:Cell Lineage; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3