title: Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Aβ) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Aβ, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention.
authors.affiliation: Institute of Molecular and Clinical Medicine, Kunming Medical University, 1168, West Chunrong Road, Yuhua Street, Chenggong New Town, Kunming 650500, China. wsnd222111@yahoo.cn
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhilong
authors.initials: Z
authors.lastname: Kang
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Zhicheng
authors.initials: Z
authors.lastname: Xiao
authors.forename: Xinfu
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D006801:Humans; D020813:Receptor, trkB / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB