title: Cowden syndrome. Early presentation, late diagnosis.
abstract: Cowden syndrome is a rare genodermatosis characterized by the formation of hamartomas in various organs and increased risk of malignancy. This disease has variable expression and often presents with subtle skin signs, which can be missed. We report a 39-year-old Saudi male who presented with acral keratoses of Cowden syndrome, and misdiagnosed and treated by many dermatologists as viral wart. We aim to increase awareness of Cowden syndrome among health care workers.
authors.affiliation: Division of Dermatology, Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Fahad National Guard Hospital, PO Box 22490, Riyadh 11426, Kingdom of Saudi Arabia. salkhenaizan@hotmail.com
authors.forename: Sultan H
authors.initials: SH
authors.lastname: Al-Khenaizan
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Mohajer
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018570:Risk Assessment; D012529:Saudi Arabia; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors; D014860:Warts