title: The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II) -thiolate clusters of Zn(7) metallothionein-3.
abstract: Silencing prion: Copper-catalyzed transformations of prion protein (PrP) lead to the production of reactive oxygen species (ROS), PrP oxidation, and cleavage and aggregation in transmissible spongiphorm encephalopathies. Zn(7) MT-3 efficiently targets Cu(II)  bound in different coordination modes to PrP-Cu(II) . By an unusual redox-dependent metal-swap reaction, MT-3 modulates the catalytic redox properties of PrP-Cu(II) .
authors.affiliation: Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. gmeloni@caltech.edu
authors.forename: Gabriele
authors.initials: G
authors.lastname: Meloni
authors.forename: Andrea
authors.initials: A
authors.lastname: Crameri
authors.forename: Günter
authors.initials: G
authors.lastname: Fritz
authors.forename: Paul
authors.initials: P
authors.lastname: Davies
authors.forename: David R
authors.initials: DR
authors.lastname: Brown
authors.forename: Peter M H
authors.initials: PM
authors.lastname: Kroneck
authors.forename: Milan
authors.initials: M
authors.lastname: Vašák
mesh_terms: D055162:Biocatalysis; D003300:Copper / Q000378:metabolism*; D006801:Humans; D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D011328:Prions / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins; D011328:Prions; D013438:Sulfhydryl Compounds; D003300:Copper; D015032:Zinc