title: Everyday action impairment in Parkinson's disease dementia.
abstract: This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors-an error type associated with executive control deficits. (JINS, 2012, 18, 1-12).
authors.affiliation: Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, USA. tgio@temple.edu
authors.forename: Tania
authors.initials: T
authors.lastname: Giovannetti
authors.forename: Priscilla
authors.initials: P
authors.lastname: Britnell
authors.forename: Laura
authors.initials: L
authors.lastname: Brennan
authors.forename: Andrew
authors.initials: A
authors.lastname: Siderowf
authors.forename: Murray
authors.initials: M
authors.lastname: Grossman
authors.forename: David J
authors.initials: DJ
authors.lastname: Libon
authors.forename: Brianne M
authors.initials: BM
authors.lastname: Bettcher
authors.forename: Francesca
authors.initials: F
authors.lastname: Rouzard
authors.forename: Joel
authors.initials: J
authors.lastname: Eppig
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Seidel
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications; D000704:Analysis of Variance; D017028:Caregivers / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D032882:Comprehension; D003704:Dementia / Q000150:complications* / Q000523:psychology; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology; D012044:Regression Analysis; D015203:Reproducibility of Results; D018434:Sickness Impact Profile