title: Atypical fibroxanthoma with dermal amyloid deposit.
abstract: Atypical fibroxanthoma (AFX) has been associated with several secondary changes, such as keloidal areas, myxoid or chondroid changes, osteoclast-like giant cells, sclerosis, fibrosis, pigmentation, hyalinization, or hemorrhagic areas. We report a case of an AFX 4 cm in diameter on the forehead of a 77-year-old male patient. There were dermal amyloid deposits intermingled with the tumor fascicles on the periphery of the lesion. A moderate inflammatory chronic lymphoplasmacytic infiltrate was found in the periphery of the tumor. The amyloid deposits were positive with Congo red staining (but negative after permanganate-treatment). The deposit was also immunostained with antibodies against CKs (AE1/AE3 and CK5/6). It did not stain with anti-amyloid A, or with antibodies against either kappa light or lambda light chains. Therefore the amyloid deposit was keratinic in nature.
authors.affiliation: Department of Pathology, Hospital El Bierzo, Medicos sin Fronteras, Ponferrada, Spain. gpyauflowerlion@terra.es
authors.forename: Angel
authors.initials: A
authors.lastname: Fernandez-Flores
mesh_terms: D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000906:Antibodies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012867:Skin / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology*; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*
chemical_list: D000682:Amyloid; D000906:Antibodies