title: [Estimation of possible use of interferon inductors for prevention of postvaccional reactions to TEOVac in animal models].
abstract: The experiments on guinea pigs showed that arbidol administered orally in a single dose 24 hours prior vaccination with TEOVAC and ridostin administered in a single dose intranasally on the 4th day after the vaccination lowered the vaccine virus accumulation in the animal organs and tissue without any effect on the vaccine immunogeneity. The results are someway indicative of the possible use of the interferon inductors for prevention of postvaccinal reactions to TEOVAC.
authors.forename: N K
authors.initials: NK
authors.lastname: Chernikova
authors.forename: T A
authors.initials: TA
authors.lastname: Bondareva
authors.forename: S V
authors.initials: SV
authors.lastname: Borisevich
authors.forename: T V
authors.initials: TV
authors.lastname: Dorokhina
authors.forename: A L
authors.initials: AL
authors.lastname: Khmelev
authors.forename: N V
authors.initials: NV
authors.lastname: Shagarova
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000276:immunology; D007369:Interferon Inducers / Q000008:administration & dosage*; D012330:RNA, Double-Stranded / Q000008:administration & dosage*; D012331:RNA, Fungal / Q000008:administration & dosage*; D012900:Smallpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects*; D014616:Vaccinia virus / Q000276:immunology; D013440:Sulfides
chemical_list: D007211:Indoles; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D012900:Smallpox Vaccine; C076741:ridostin; C086979:umifenovir; D013440:Sulfides