title: [Calcified].
abstract: A 73-year-old woman was referred due to an acute and progressive worsening of a previously mildly impaired kidney function of unknown origin. The kidney biopsy showed a phosphate nephropathy. We identified Colophos®, a phosphate-containing purgative as the causing agent, which the patient had received for bowel cleansing for a colonoscopy one day before the detection of the acute kidney failure. During the following months the kidney function initially declined further and then improved. Most cases of phosphate nephropathy are associated with the ingestion of phosphate-containing purgatives. Persons at risk are women, elderly persons, patients with impaired kidney function, hypertension, and dehydration. The consequence is sometimes an irreversible tubulointerstitial injury that can lead to end-stage renal disease in a minority of the cases.
authors.affiliation: Klinik für Nephrologie, Universitätsspital Zürich, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Gerber
authors.forename: A
authors.initials: A
authors.lastname: Gaspert
authors.forename: J A
authors.initials: JA
authors.lastname: Bleisch
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D001706:Biopsy; D002114:Calcinosis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002400:Cathartics; D010710:Phosphates; D004008:Diclofenac; C018279:sodium phosphate