title: Retinoblastoma in the democratic republic of congo: 20-year review from a tertiary hospital in kinshasa.
abstract: Background. To determine clinical profile and management of retinoblastoma among children at Kinshasa in Democratic Republic of Congo. Patients and methods. The medical records of patients with a diagnosis of retinoblastoma seen at the University Hospital of Kinshasa from January 1985 till December 2005 were retrospectively reviewed. Demographic profile, clinical data, modes of treatment and outcome were analysed. Results. A total of 49 children, of whom 40 had adequate data on record were identified as retinoblastoma (28 males and 12 females). Nine cases had bilateral disease. The median age at the first symptoms was 9 months (range, 1 month to 6 years) for unilateral retinoblastoma and 18 months (range, 1 month to 3.5 years) for bilateral retinoblastoma. The median age at the first oncology consultation was 2.4 years (range, 6 months to 6 years) for unilateral retinoblastoma and 2.4years (range, 9 months to 4 years) for bilateral disease. Leukokoria was present in 67.5% of subjects. Seventy-five percent abandoned the treatment. The mortality was 92.5%. Conclusion. In Democratic Republic of Congo, retinoblastoma remains a life threatening disease characterized by late referral to a specialized unit and affordability of chemotherapy; all leading to an extension of the disease and high mortality.
authors.affiliation: Division of Paediatric Haematology and Oncology, Department of Paediatrics, University Hospital of Kinshasa, P.O. Box 123, Kinshasa, Democratic Republic of Congo.
authors.forename: Aimé
authors.initials: A
authors.lastname: Kazadi Lukusa
authors.forename: Michel Ntetani
authors.initials: MN
authors.lastname: Aloni
authors.forename: Bertin
authors.initials: B
authors.lastname: Kadima-Tshimanga
authors.forename: Moïse
authors.initials: M
authors.lastname: Mvitu-Muaka
authors.forename: Jean Lambert
authors.initials: JL
authors.lastname: Gini Ehungu
authors.forename: René
authors.initials: R
authors.lastname: Ngiyulu
authors.forename: Pépé
authors.initials: P
authors.lastname: Ekulu Mfutu
authors.forename: Aléine
authors.initials: A
authors.lastname: Budiongo Nzazi