title: Direct electrophilic N-trifluoromethylation of azoles by a hypervalent iodine reagent.
abstract: Effective CF(3)  transfer: Various electron-rich nitrogen heterocycles (pyrazoles, triazoles, and tetrazoles) can be directly N-trifluoromethylated by a hypervalent iodine reagent in an efficient manner. The optimized procedure, which includes an in situ silylation of the substrate followed by an acid-catalyzed CF(3)  transfer, provides ready access to a series of new and previously challenging or inaccessible NCF(3)  compounds.
authors.affiliation: Departement Chemie und Angewandte Biowissenschaften, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland.
authors.forename: Katrin
authors.initials: K
authors.lastname: Niedermann
authors.forename: Natalja
authors.initials: N
authors.lastname: Früh
authors.forename: Remo
authors.initials: R
authors.lastname: Senn
authors.forename: Barbara
authors.initials: B
authors.lastname: Czarniecki
authors.forename: René
authors.initials: R
authors.lastname: Verel
authors.forename: Antonio
authors.initials: A
authors.lastname: Togni
mesh_terms: D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D017611:Fluorine Compounds / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D001393:Azoles; D017611:Fluorine Compounds; D007455:Iodine