title: [Breakdown of fat tissue and muscle protein under remifentanil anesthesia].
abstract: BACKGROUND
  We investigated the efficacy of glucose infusion for the inhibition of breakdown of fat tissue and muscle protein under remifentanil anesthesia.
  
  
  METHODS
  Twenty adult patients (ASA I or II) were enrolled in this study and randomized into two groups: a control group receiving acetated Ringer's solution without glucose (n = 10) and a glucose group receiving acetated Ringer's solution containing 1% glucose (n = 10). Anesthesia was induced by propofol and fentanyl and maintained by sevoflurane and remifentanil. Plasma concentrations of glucose and cortisol were measured. Acetoacetic acid and 3-hydroxybutyrate acid were measured as parameters for breakdown of fat tissue. Urine 3-methylhistidine/plasma creatinine was measured as a parameter for breakdown of muscle protein during surgery. Data were analyzed by the unpaired t-test, Friedman's chi2-test, Wilcoxon's t-test and Mann-Whitney U test. P < 0.05 was considered significant.
  
  
  RESULTS
  Plasma concentrations of cortisol and glucose were not increased in either group during the study. Plasma concentrations of acetoacetic acid and 3-hydroxybutyrate acid and urine 3-methylhistidine/plasma creatinine significantly increased in the control group but did not increase in the glucose group.
  
  
  CONCLUSIONS
  Infusion of glucose suppresses breakdown of fat tissue and muscle protein under remifentanil anesthesia.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060-8543.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sawada
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Watanabe
authors.forename: Michiaki
authors.initials: M
authors.lastname: Yamakage
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D007552:Isotonic Solutions; D009124:Muscle Proteins; D010880:Piperidines; C028570:Ringer's acetate; D005947:Glucose; D000077208:Remifentanil