title: Serum lactate is a useful predictor of death in severe sepsis in patients with pemphigus vulgaris.
abstract: BACKGROUND
  Serum lactate is a useful prognostic marker in severe sepsis; high levels of serum lactate in critically ill patients are related to high mortality risk; assessing serum lactate levels in patients with pemphigus vulgaris is justified. The objective was to determine the role of serum lactate as a predictor of shock and its outcome in patients with pemphigus vulgaris and severe sepsis without acute organ dysfunction.
  
  
  METHODS
  Thirty-seven patients with pemphigus vulgaris, 22 with severe sepsis and 15 without sepsis. Blood lactate levels were analyzed. The outcome was recorded as survival or non-survival.
  
  
  RESULTS
  High serum lactate levels, compared with intermediate and low levels, were significantly associated with increased 28-day mortality in patients with severe sepsis. The 28-day mortality for the cohort was 27.3%.
  
  
  CONCLUSIONS
  Initial serum lactate was associated with mortality in pemphigus vulgaris with severe sepsis. Patients with severe sepsis and with high serum lactate levels (≥ 4 mmol/L) constitute a potential risk group that may benefit from more aggressive treatment.
authors.affiliation: Servicio de Dermatología, Hospital General de México, DF, México. atsdermahgm@gmail.com
authors.forename: Andrés
authors.initials: A
authors.lastname: Tirado-Sánchez
authors.forename: Denisse
authors.initials: D
authors.lastname: Vázquez-González
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Ponce-Olivera
authors.forename: Griselda
authors.initials: G
authors.lastname: Montes de Oca-Sánchez
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications; D015897:Comorbidity; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D016015:Logistic Models; D008297:Male; D010392:Pemphigus / Q000097:blood* / Q000453:epidemiology; D011379:Prognosis; D012141:Respiratory Tract Infections / Q000150:complications; D018805:Sepsis / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D018461:Soft Tissue Infections / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications; D055815:Young Adult
chemical_list: D019344:Lactic Acid