title: Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events.
abstract: Nonalcoholic steatohepatitis (NASH) is an independent predictor of coronary artery disease (CAD). Our aim was to compare the incidence of cardiovascular (CV) events between patients transplanted for NASH and alcohol (ETOH)-induced cirrhosis. This is a retrospective cohort study (August 1993 to March 2010) of 242 patients (115 NASH and 127 ETOH) with ≥12 months follow-up after liver transplantation (LT). Those with hepatocellular carcinoma or coexisting liver diseases were excluded. Kaplan-Meier's and Cox's proportional hazard analyses were conducted to compare survival. Logistic regression was used to calculate the likelihood of CV events, defined as death from any cardiac cause, myocardial infarction, acute heart failure, cardiac arrest, arrhythmia, complete heart block, and/or stroke requiring hospitalization <1 year after LT. Patients in the NASH group were older (58.4 versus 53.3 years) and were more likely to be female (45% versus 18%; P < 0.001). They were more likely to be morbidly obese (32% versus 9%), have dyslipidemia (25% versus 6%), or have hypertension (53% versus 38%; P < 0.01). On multivariate analysis, NASH patients were more likely to have a CV event <1 year after LT, compared to ETOH patients, even after controlling for recipient age, sex, smoking status, pretransplant diabetes, CV disease, and the presence of metabolic syndrome (26% versus 8%; odds ratio = 4.12; 95% confidence interval = 1.91-8.90). The majority (70%) of events occurred in the perioperative period, and the occurrence of a CV event was associated with a 50% overall mortality. However, there were no differences in patient, graft, or CV mortality between groups.
  
  
  CONCLUSIONS
  CV complications are common after LT, and NASH patients are at increased risk independent of traditional cardiac risk factors, though this did not affect overall mortality.
authors.affiliation: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Vanwagner
authors.forename: Manali
authors.initials: M
authors.lastname: Bhave
authors.forename: Helen S
authors.initials: HS
authors.lastname: Te
authors.forename: Joe
authors.initials: J
authors.lastname: Feinglass
authors.forename: Lisa
authors.initials: L
authors.lastname: Alvarez
authors.forename: Mary E
authors.initials: ME
authors.lastname: Rinella
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality*; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology; D005234:Fatty Liver / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006323:Heart Arrest / Q000453:epidemiology; D006327:Heart Block / Q000453:epidemiology; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D065626:Non-alcoholic Fatty Liver Disease; D009767:Obesity, Morbid / Q000150:complications / Q000453:epidemiology; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology