title: Trends in antihypertensives use among Moroccan patients.
abstract: OBJECTIVE
  In this study, we analyzed the consumption trends of antihypertensives in Morocco during the 1991-2010 period and the impacts after the institution of Mandatory Health Insurance and the marketing of generic drugs.
  
  
  METHODS
  We used sales data from the Moroccan subsidiary of IMS Health "Intercontinental Marketing Service". The consumption volumes were converted into defined daily doses (DDDs).
  
  
  RESULTS
  Between 1991 and 2010, outpatient consumption of antihypertensives went from 4.37 to 23.14 DDD/1000 inhabitants/day, a 5.30-fold increase. In 2010, calcium channel blockers (CCBs) and angiotensin converting enzyme inhibitors (ACEI) were the most consumed (4.97 DDD/1000 inhabitants/day) for each one, followed by diuretics (4.20 DDD/1000 inhabitants/day). The most consumed products were amlodipine (4.27 DDD/1000 inhabitants/day) followed by ramipril (3.18 DDD/1000 inhabitants /day) and indapamide (1.72 DDD/1000inhabitants/day). Between 1991 and 2010, the consumption of generic antihypertensives went from 2% to 46%.
  
  
  CONCLUSIONS
  Antihypertensive consumption increased between 1991 and 2010. However, despite the increase of generic drugs consumption, the levels of antihypertensive consumption remain lower than the needs of hypertensive patients.
authors.affiliation: Research Team of Pharmacoepidemiology & Pharmacoeconomics, Laboratory of Pharmacology & Toxicology, Faculty of Medicine & Pharmacy, University Mohammed V-Souissi, Rabat, Morocco. berradaghizlane_1@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Berrada El Azizi
authors.forename: S
authors.initials: S
authors.lastname: Ahid
authors.forename: I
authors.initials: I
authors.lastname: Ghanname
authors.forename: A
authors.initials: A
authors.lastname: Belaiche
authors.forename: M
authors.initials: M
authors.lastname: Hassar
authors.forename: Y
authors.initials: Y
authors.lastname: Cherrah
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data / Q000639:trends*; D016568:Drugs, Generic / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007348:Insurance, Health / Q000706:statistics & numerical data / Q000639:trends; D009018:Morocco
chemical_list: D000959:Antihypertensive Agents; D016568:Drugs, Generic