title: Silver triflate and palladium acetate co-catalyzed reaction of N'-(2-alkynylbenzylidene)hydrazide with N-allyl ynamide.
abstract: A silver triflate and palladium acetate co-catalyzed reaction of N'-(2-alkynylbenzylidene)hydrazide with N-allyl ynamide is described, which generates 2-amino-H-pyrazolo[5,1-a]isoquinolines in good to excellent yield. The transformation proceeds with high efficiency through 6-endo cyclization, [3 + 2] cycloaddition, 3,3-sigmatropic rearrangement, and aromatization.
authors.affiliation: Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi 330022, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Yang
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Peng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006834:Hydrazines / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000577:Amides; D006834:Hydrazines; D007546:Isoquinolines; D008698:Mesylates; D012834:Silver; D010165:Palladium; C012077:trifluoromethanesulfonic acid