title: Ras and Rho small G proteins: insights from the Schizophyllum commune genome sequence and comparisons to other fungi.
abstract: Unlike in animal cells and yeasts, the Ras and Rho small G proteins and their regulators have not received extensive research attention in the case of the filamentous fungi. In an effort to begin to rectify this deficiency, the genome sequence of the basidiomycete mushroom Schizophyllum commune was searched for all known components of the Ras and Rho signalling pathways. The results of this study should provide an impetus for further detailed investigations into their role in polarized hyphal growth, sexual reproduction and fruiting body development. These processes have long been the targets for genetic and cell biological research in this fungus.
authors.affiliation: Department of Biology, University of Turku, Biocity A, Tykistökatu 6A, FI-20520 Turku, Finland.
authors.forename: Marjatta
authors.initials: M
authors.lastname: Raudaskoski
authors.forename: Erika
authors.initials: E
authors.lastname: Kothe
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Fowler
authors.forename: Elke-Martina
authors.initials: EM
authors.lastname: Jung
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Horton
mesh_terms: D000595:Amino Acid Sequence; D003599:Cytoskeleton / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D020555:GTP-Binding Protein Regulators / Q000235:genetics* / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012567:Schizophyllum / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D020555:GTP-Binding Protein Regulators; D018631:ras Proteins; D020741:rho GTP-Binding Proteins