title: Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.
abstract: Based on the specific folic acid-folate receptor (FA-FR) interaction, macromolecular FR can bind with FA-linked DNA-small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety (Fuzhou University), Department of Chemistry, Fuzhou University, Fuzhou, 350002, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wei
authors.forename: Wenlie
authors.initials: W
authors.lastname: Lin
authors.forename: Na
authors.initials: N
authors.lastname: Ma
authors.forename: Fang
authors.initials: F
authors.lastname: Luo
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Lin
authors.forename: Longhua
authors.initials: L
authors.lastname: Guo
authors.forename: Bin
authors.initials: B
authors.lastname: Qiu
authors.forename: Guonan
authors.initials: G
authors.lastname: Chen
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D005453:Fluorescence; D058973:Folate Receptors, GPI-Anchored / Q000032:analysis* / Q000737:chemistry* / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008970:Molecular Weight
chemical_list: D058973:Folate Receptors, GPI-Anchored; D004247:DNA; D005492:Folic Acid; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III