title: Arylamine  N-acetyltransferase 2 genotypes in a Mexican population.
abstract: The acetylating activity of N-acetyltransferase 2  (NAT2) has critical implications for therapeutics and disease susceptibility.  To date, several polymorphisms that alter the enzymatic activity and/or protein  stability of NAT2 have been identified. We examined the distribution and  frequency of NAT2 genotypes in the Mexican population. Among 250 samples  amplified and sequenced for the NAT2 gene, we found seven different  SNPs; the most frequent allele was 803 A>G (35.8%), followed by 282 C>T,  341 T>C, and 481 C>T. There were no differences in the distribution of  SNPs between healthy subjects and cancer patients. These eight polymorphisms  defined 26 diplotypes; 11.6% were wild type (NAT2*4/NAT2*4), while the  most common diplotype was NAT2*4/NAT2*5B, present in 17.2%. We did not  identify other common polymorphisms. The results were compared with the NAT2 SNPs reported from other populations. All but the Turkish population was  significantly different from ours. We conclude that the mixed-race Mexican  population requires special attention because NAT2 genotype frequencies  differ from those in other regions of the world.
authors.affiliation: Division of Basic Research, National Cancer Institute of Mexico, Mexico City, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Taja-Chayeb
authors.forename: J A
authors.initials: JA
authors.lastname: Agúndez
authors.forename: C
authors.initials: C
authors.lastname: Miguez-Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Chavez-Blanco
authors.forename: A
authors.initials: A
authors.lastname: Dueñas-Gonzalez
mesh_terms: D000107:Acetylation; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008800:Mexico; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human