title: Chromatin-remodeling complex specificity and embryonic vascular development.
abstract: Vascular development is a dynamic process that relies on the coordinated expression of numerous genes, but the factors that regulate gene expression during blood vessel development are not well defined. ATP-dependent chromatin-remodeling complexes are gaining attention for their specific temporal and spatial effects on gene expression during vascular development. Genetic mutations in chromatin-remodeling complex subunits are revealing roles for the complexes in vascular signaling pathways at discrete developmental time points. Phenotypic analysis of these models at various stages of vascular development will continue to expand our understanding of how chromatin remodeling impacts new blood vessel growth. Such research could also provide novel therapeutic targets for the treatment of vascular pathologies.
authors.affiliation: Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA, carol-curtis@omrf.org.
authors.forename: Carol D
authors.initials: CD
authors.lastname: Curtis
authors.forename: Reema B
authors.initials: RB
authors.lastname: Davis
authors.forename: Kyle G
authors.initials: KG
authors.lastname: Ingram
authors.forename: Courtney T
authors.initials: CT
authors.lastname: Griffin
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001808:Blood Vessels / Q000196:embryology / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008955:Models, Cardiovascular; D018919:Neovascularization, Physiologic / Q000235:genetics*
chemical_list: D002843:Chromatin; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases