title: Effects of varying temporal scale on spatial models of mortality patterns attributed to pediatric diarrhea.
abstract: Public health data is often highly aggregated in time and space. The consequences of temporal aggregation for modeling in support of policy decisions have largely been overlooked. We examine the effects of changing temporal scale on spatial regression models of pediatric diarrhea mortality patterns, mortality rates and mortality peak timing, in Mexico. We compare annual and decadal level univariate models that incorporate known risk factors. Based on normalized sums of squared differences we compare between annual and decadal coefficients for variables that were significant in decadal models. We observed that spurious relationships might be created through aggregating time scales; obscuring interannual variation and resulting in inflated model diagnostics. In fact, variable selection and coefficient values can vary with changing temporal aggregation. Some variables that were significant at the decadal level were not significant at the annual level. Implications of such aggregation should be part of risk communication to policy makers.
authors.affiliation: Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, DHHS, Bethesda, MD, USA. stefan.leyk@colorado.edu
authors.forename: S
authors.initials: S
authors.lastname: Leyk
authors.forename: B J J
authors.initials: BJ
authors.lastname: McCormick
authors.forename: J R
authors.initials: JR
authors.lastname: Nuckols
mesh_terms: D002675:Child, Preschool; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D003967:Diarrhea / Q000401:mortality*; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D062306:Geography, Medical / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D062211:Spatio-Temporal Analysis