title: Lipid profiles and risk of breast and ovarian cancer in the Swedish AMORIS study.
abstract: BACKGROUND
  Obesity is a risk factor for breast and ovarian cancer; the mechanisms of action are not completely understood. Perturbed lipid metabolism often accompanies obesity; we therefore ascertained the associations between lipid components and breast and ovarian cancer risk in a prospective cohort study.
  
  
  METHODS
  A total of 234,494 women with baseline measurements of triglycerides and total cholesterol and glucose were selected from the AMORIS database.A total of 27,394 had measurements of high-density lipoprotein, low-density lipoprotein, apolipoprotein (Apo) B, and A-I. Associations between quartiles and dichotomized values of lipid components and breast and ovarian cancer risk were analyzed using Cox proportional hazard models.
  
  
  RESULTS
  We identified 6,105 women diagnosed with breast cancer and 808 women diagnosed with ovarian cancer. A weak trend was observed between triglycerides and breast cancer (HR, 1.01, 95% Confidence Interval, 0.94-1.09; 0.93 (0.86-1.00) 0.91 (0.84-0.99), second, third, and fourth quartiles; P = 0.01). No other associations between lipid components and risk of breast cancer or ovarian cancer showed statistical significance.
  
  
  CONCLUSIONS
  A weak protective association was found between levels of triglycerides and risk of breast cancer.
  
  
  CONCLUSIONS
  An analysis including information on tumour characteristics of ovarian cancer and breast cancer may provide more insight in possible links between lipid metabolism and the risk of these cancers.
authors.affiliation: 1King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom. jennifer.melvin@kcl.ac.uk
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Melvin
authors.forename: Divya
authors.initials: D
authors.lastname: Seth
authors.forename: Lars
authors.initials: L
authors.lastname: Holmberg
authors.forename: Hans
authors.initials: H
authors.lastname: Garmo
authors.forename: Niklas
authors.initials: N
authors.lastname: Hammar
authors.forename: Ingmar
authors.initials: I
authors.lastname: Jungner
authors.forename: Göran
authors.initials: G
authors.lastname: Walldius
authors.forename: Mats
authors.initials: M
authors.lastname: Lambe
authors.forename: Annette
authors.initials: A
authors.lastname: Wigertz
authors.forename: Mieke
authors.initials: M
authors.lastname: Van Hemelrijck
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol