title: Comparison of glaucoma diagnoses using Stratus and Cirrus optical coherence tomography in different glaucoma types in a Chinese population.
abstract: OBJECTIVE
  To compare the glaucoma diagnostic power of Stratus and Cirrus optical coherence tomographies (OCTs) in a Taiwan Chinese population with different glaucoma types.
  
  
  METHODS
  One eye each was chosen from 21 ocular hypertension (OH) patients, 27 glaucoma-suspect (GS) patients, 35 primary open-angle glaucoma (POAG) patients, 26 primary angle-closure glaucoma (PACG) patients, and 52 normal subjects. Early glaucoma (EG) was identified among glaucomatous eyes on the basis of the visual field severity (better than -9 dB). All participants were imaged using 2 OCT units at the same visit. The area under the receiver operator characteristic (AROC) curve was used to differentiate normal eyes from OH, GS, POAG, PACG, and EG eyes, and the sensitivity and specificity of each parameter from internal normative classifications were analyzed.
  
  
  RESULTS
  For normal versus OH eyes, the best AROC value was the average thickness (Stratus, 0.693; Cirrus, 0.697). For normal versus GS eyes, the best AROC value was the average thickness (Stratus, 0.807; Cirrus, 0.776). For normal versus POAG eyes, the best AROC value was the average thickness (Stratus, 0.943; Cirrus, 0.930). For normal versus PACG eyes, the best AROC value was the 5-o'clock hour (Stratus, 0.830; Cirrus, 0.817). For normal versus EG eyes, the best AROC value was the average thickness with Stratus (0.868) and the 5-o'clock hour with Cirrus (0.876). All sensitivities in the 5 groups were fair on the basis of the internal normal classification database of both OCTs.
  
  
  CONCLUSIONS
  Cirrus and Stratus OCTs showed equal diagnostic power in EG, OH, GS, POAG, and PACG eyes in a Taiwan Chinese population. The utility of the current internal databases of both OCT units for the Chinese population is an interesting issue that needs to be addressed in the future.
authors.affiliation: *Graduate Institute of Clinical Medical Science, Medical College, China Medical University †Glaucoma Service, Department of Ophthalmology, China Medical University Hospital ∥Department of Integrated Medicine, Chinese College, China Medical University, Taichung ‡Department of Mathematics, Tamkang University §Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Chen
authors.forename: Yue-Cune
authors.initials: YC
authors.lastname: Chang
authors.forename: I-Jong
authors.initials: IJ
authors.lastname: Wang
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Chen
mesh_terms: D000328:Adult; D019540:Area Under Curve; D044466:Asian People / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000208:ethnology; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000208:ethnology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis* / Q000208:ethnology; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000208:ethnology; D011446:Prospective Studies; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013624:Taiwan / Q000453:epidemiology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D014794:Visual Fields