title: Synthesis, spectral and antibacterial sudies of copper(II) tetraaza macrocyclic complexes.
abstract: A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX(2)] (where L = N(4) donor macrocyclic ligands) and (X = Cl(-), NO(3) (-)) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl(2) and [Cu(DBACDT)](NO(3))(2) complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India.|Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan.
authors.forename: Puchakayala Muralidhar
authors.initials: PM
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India.|Department of Chemistry, National Dong Hwa University, Hualien 974, Taiwan.
authors.forename: Rondla
authors.initials: R
authors.lastname: Rohini
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India.
authors.forename: Edulla Ravi
authors.initials: ER
authors.lastname: Krishna
authors.affiliation: Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Anren
authors.initials: A
authors.lastname: Hu
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, A.P, India.
authors.forename: Vadde
authors.initials: V
authors.lastname: Ravinder
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D002433:Cefaclor / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D000069349:Linezolid; D047028:Macrocyclic Compounds / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D047028:Macrocyclic Compounds; D023303:Oxazolidinones; D002433:Cefaclor; D003300:Copper; D000069349:Linezolid