title: Hyperuricemia and the echocardiographic measures of myocardial dysfunction.
abstract: Few studies have investigated the association between hyperuricemia and subclinical myocardial dysfunction. The authors analyzed the relationship between serum uric acid and subclinical markers of heart failure in participants in the Framingham Offspring Cohort (N=2169, mean age 57.3 years, 55.4% women). Cardiac dysfunction was assessed through echocardiographic measurements of left ventricular (LV) mass and thickness, end-diastolic LV thickness, and LV fractional shortening at the sixth visit, approximately 24 years after study onset. Participants in the highest serum uric acid quartile (≥ 6.2 mg/dL serum uric acid) had a significantly greater frequency of echocardiographic abnormalities compared with those in the lowest quartile (<4.3 mg/dL). Those in the highest quartile had multivariable-adjusted odds ratios of 9.013 (95% confidence interval, 2.051-39.604) for abnormal LV ejection fraction and 4.584 (95% confidence interval, 1.951-10.768) for LV systolic dysfunction compared with those in the lowest quartile. Hyperuricemia in young adults can be a marker for subsequent heart failure.
authors.affiliation: Stanford University School of Medicine, Palo Alto, CA 94304, USA. e.krishnan@stanford.edu
authors.forename: Eswar
authors.initials: E
authors.lastname: Krishnan
authors.forename: Ali
authors.initials: A
authors.lastname: Hariri
authors.forename: Omar
authors.initials: O
authors.lastname: Dabbous
authors.forename: Bhavik J
authors.initials: BJ
authors.lastname: Pandya
mesh_terms: D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D033461:Hyperuricemia / Q000150:complications*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging
chemical_list: D014527:Uric Acid