title: Bandpass filter settings differentially affect measurement of P50 sensory gating in children and adults.
abstract: OBJECTIVE
  This study investigated the effect of four different bandpass filter settings on measures of the P50 component and the signal-to-noise ratios (SNR) of averaged ERPs obtained from a sensory gating paradigm employing paired-click stimuli.
  
  
  METHODS
  Participants were adults (n=18) 20-55years old and children (n=25) 5-10years old who were free of neurological disorders.
  
  
  RESULTS
  Results show that the filter settings (0.23-75Hz, 10-50Hz, 10-75Hz, and 10-200Hz) differentially affected the P50 amplitude, noise power and SNR measures of the conditioning and test clicks, and P50 T/C ratios.
  
  
  CONCLUSIONS
  The 10-50Hz filter setting may be optimal in studies that include only adults as these settings resulted in the smallest mean P50 T/C ratio, a reasonable standard deviation (SD) for the ratio, and the highest SNRs. The 10-200Hz filter may be the best for studying young children as this setting had the smallest mean and SD of P50 T/C ratios for these participants.
  
  
  CONCLUSIONS
  In studies that include both adults and children investigators are advised to use the 10-200Hz filter setting because the smaller variability of sensory gating in the child group helps ensure better homogeneity of variance measures between the groups.
authors.affiliation: Department of Occupational Therapy, Creighton University, Omaha, NE 68178, USA.
authors.forename: Wen-Pin
authors.initials: WP
authors.lastname: Chang
authors.forename: William J
authors.initials: WJ
authors.lastname: Gavin
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Davies
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods*; D055724:Electrophysiological Phenomena / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055139:Sensory Gating / Q000502:physiology*; D059629:Signal-To-Noise Ratio