title: Indolent CD8-positive T-cell lymphoid proliferation of the ear: a report of two cases.
abstract: The current classification of primary cutaneous T-cell lymphoma (CTCL) of the World Health Organization (WHO) includes primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma as a provisional entity awaiting cumulative data. Recent reports identify CD3/CD8-positive clonal T-cell lymphoid proliferations arising in the ear and nose that behave indolently and therefore defy currently established subclassification. Here, we report two cases of clonal CD8-positive/granzyme-B-negative T-cell lymphoid proliferations that arose in the ear and behaved indolently. Collectively, these cases suggest that an additional category of cutaneous indolent CD8-positive T-cell lymphoma may be necessary among the existing classification schemes.
authors.affiliation: Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA.
authors.forename: Weifen
authors.initials: W
authors.lastname: Zeng
authors.forename: Victor E
authors.initials: VE
authors.lastname: Nava
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
authors.forename: Metin
authors.initials: M
authors.lastname: Ozdemirli
mesh_terms: D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D049109:Cell Proliferation; D004428:Ear Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*