title: Sequential use with imiquimod and surgery in extramammary Paget's disease.
abstract: Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma which occurs in areas rich in apocrine glands. Although surgery is the treatment of choice, numerous noninvasive treatments have been tried. There are studies that have demonstrated the efficacy of imiquimod to treat Extramammary Paget's disease, but we found no mention in the literature of its use as neoadjuvant therapy previous to surgery excision. We present a case of a large plaque of extramammary Paget's disease successfully treated with imiquimod and minor surgery of the residual disease.
authors.affiliation: Dermatology, Hospital General Universitario de Alicante, Alicante, Spain. fernandotoledoalberola@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Toledo
authors.forename: J F
authors.initials: JF
authors.lastname: Silvestre
authors.forename: L
authors.initials: L
authors.lastname: Cuesta
authors.forename: I
authors.initials: I
authors.lastname: Ballester
authors.forename: N
authors.initials: N
authors.lastname: Latorre
authors.forename: A
authors.initials: A
authors.lastname: Monteagudo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod