title: Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma.
abstract: Both primary and transformed cells need cholesterol for their growth. Guo and colleagues unraveled the connection between epidermal growth factor receptor mutations in glioblastoma and increased cholesterol influx via sterol regulatory element-binding protein 1 and low-density lipoprotein receptor (LDLR) increase. They propose the activation of the liver X receptor-inducible degrader of LDLR-LDLR axis as a therapeutic approach to reduce intracellular cholesterol, block tumor growth, and induce cell death.
authors.affiliation: Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Bari, Italy. moschetta@negrisud.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Moschetta
mesh_terms: D016923:Cell Death / Q000187:drug effects / Q000235:genetics; D002784:Cholesterol / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005909:Glioblastoma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008024:Ligands; D000071518:Liver X Receptors; D058990:Molecular Targeted Therapy / Q000379:methods; D009154:Mutation; D057093:Orphan Nuclear Receptors / Q000235:genetics / Q000378:metabolism*; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D011973:Receptors, LDL; D051780:Sterol Regulatory Element Binding Protein 1; D002784:Cholesterol; D066246:ErbB Receptors