title: A peptide talk between JC virus and the human host: from silent infection to autoimmunity.
abstract: Analysis of JC virus (JCV) polyprotein for peptide sharing with the human proteome reveals that the virus has hundreds of pentapeptide sequences in common with the human proteins. The datum is interesting in light of the fundamental role exerted by short amino acid sequences in protein-protein interactions and, consequently, in biochemical reactions and immune recognition. Searching for new approaches to understand the JCV infection scenarios, from the immunoevasion phenomenon underlying the viral asymptomatic stay in the human host to the (re)activation phase and associated pathogenic sequelae, the present study describes the diffuse pentapeptide communication network between JCV and the human host.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bari, Italy. guglielmo.lucchese@gmail.com
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Lucchese
mesh_terms: D015551:Autoimmunity / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000276:immunology; D007577:JC Virus / Q000502:physiology*; D009842:Oligopeptides / Q000235:genetics / Q000276:immunology*; D027601:Polyomavirus Infections / Q000235:genetics / Q000276:immunology*; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*; D017735:Virus Latency / Q000276:immunology
chemical_list: D009842:Oligopeptides; D014764:Viral Proteins