title: DISC1 and the aggresome: a disruption to cellular function?
abstract: Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene for major psychiatric disorders. DISC1 plays a role in key neuronal processes such as neuronal proliferation, migration, integration and function via DISC1's roles at the centrosome and synapse, and in the regulation of intracellular signaling pathways. Recently, the idea of protein aggregation as a disease mechanism for DISC1 has been suggested. In our recent paper we explore these DISC1 protein aggregates in cell lines and neurons and find they are recruited to the aggresome and cause disruption of DISC1 function in intracellular transport.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
authors.forename: Talia
authors.initials: T
authors.lastname: Atkin
authors.forename: Josef
authors.initials: J
authors.lastname: Kittler
mesh_terms: D002460:Cell Line; D002477:Cells / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism*; D017510:Protein Folding; D020836:Protein Structure, Quaternary; D012559:Schizophrenia / Q000378:metabolism / Q000473:pathology / Q000628:therapy
chemical_list: D009419:Nerve Tissue Proteins