title: Filamentous bacteriophage fd as an antigen delivery system in vaccination.
abstract: Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer's Disease and cancer.
authors.affiliation: Institute of Genetics and Biophysics, CNR, via P. Castellino 111, 80131, Naples, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Prisco
authors.affiliation: Institute of Protein Biochemistry, CNR, via P. Castellino 111, 80131, Naples, Italy.
authors.forename: Piergiuseppe
authors.initials: P
authors.lastname: De Berardinis
mesh_terms: D016229:Amyloid beta-Peptides / Q000276:immunology; D000818:Animals; D017104:Bacteriophage M13 / Q000276:immunology*; D002213:Capsid / Q000276:immunology / Q000378:metabolism; D036022:Capsid Proteins / Q000276:immunology* / Q000378:metabolism; D061505:Cell Surface Display Techniques / Q000379:methods*; D003713:Dendritic Cells / Q000276:immunology; D004337:Drug Carriers / Q000008:administration & dosage*; D051379:Mice; D019151:Peptide Library; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination / Q000379:methods; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D036022:Capsid Proteins; D004337:Drug Carriers; D019151:Peptide Library; D022223:Vaccines, Subunit; C025668:coat protein, Bacteriophage M13