title: rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.
abstract: BACKGROUND
  Colorectal cancer is the third most incident cancer and cause of cancer-related death in the United States. MicroRNAs, a class of small non-coding RNAs, have been implicated in the pathogenesis and prognosis of colorectal cancer, although few studies have examined the relationship between germline mutation in the microRNAs with risk and prognosis. We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer.
  
  
  RESULTS
  A cohort consisting of 245 cases and 446 controls was genotyped for rs4919510. The frequency of the GG genotype was significantly higher in African Americans (15%) compared to Caucasians (3%) controls. There was no significant association between rs4919510 and colorectal cancer risk (African American: OR(GG vs. CC) 0.89 [95% CI, 0.41-1.80]) (Caucasian: OR(GG vs. CC) 1.76, ([95% CI, 0.48-6.39]). However, we did observe an association with survival. The GG genotype was associated with an increased risk of death in Caucasians (HR(GG vs. CC) 3.54 ([95% CI, 1.38-9.12]) and with a reduced risk of death in African Americans (HR(GG vs. CC) 0.36 ([95% CI 0.12-1.07).
  
  
  CONCLUSIONS
  These results suggest that rs4910510 may be associated with colorectal cancer survival in a manner that is dependent on race.
authors.affiliation: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
authors.forename: Bríd M
authors.initials: BM
authors.lastname: Ryan
authors.forename: Andrew C
authors.initials: AC
authors.lastname: McClary
authors.forename: Nicola
authors.initials: N
authors.lastname: Valeri
authors.forename: Dillon
authors.initials: D
authors.lastname: Robinson
authors.forename: Alessio
authors.initials: A
authors.lastname: Paone
authors.forename: Elise D
authors.initials: ED
authors.lastname: Bowman
authors.forename: Ana I
authors.initials: AI
authors.lastname: Robles
authors.forename: Carlo
authors.initials: C
authors.lastname: Croce
authors.forename: Curtis C
authors.initials: CC
authors.lastname: Harris
mesh_terms: D001741:Black or African American / Q000235:genetics; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality; D005260:Female; D011905:Genes, ras; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: D035683:MicroRNAs