title: Evaluation of dose reduction and image quality in chest CT using adaptive statistical iterative reconstruction with the same group of patients.
abstract: OBJECTIVE
  The objective of this study was to compare the image quality and radiation dose of chest CT images reconstructed with a blend of adaptive statistical iterative reconstruction (ASIR) and filtered back-projection (FBP) with images generated using conventional FBP.
  
  
  METHODS
  Patients with chest CT re-examinations were alternately assigned to two scanners with different reconstruction techniques. The study groups included noise index (NI) 11 with 30% ASIR (A30), NI 13 with 40% ASIR (A40), NI 15 with 50% ASIR (A50) and NI 17 with 60% ASIR (A60), sequentially changed every 2 months. The control images were obtained using FBP and NI 11. All acquisitions were performed with automatic dose modulation. Paired t-test and non-parameter test were applied to compare the difference.
  
  
  RESULTS
  The radiation doses were significantly lower in the examinations that used ASIR (p<0.001). The mean dose reduction rate was 27.7%, 45.2%, 57.1% and 71.8% for Groups A30, A40, A50 and A60, respectively. The image quality of Groups A30-A50 was not inferior to that of the control examinations. The image noise of Group A60 was greater and subjective image quality was inferior to that of the control.
  
  
  CONCLUSIONS
  ASIR enabled the use of a higher NI with automatic dose modulation. With 50% ASIR and a NI of 15, the effective radiation dose was reduced by 57%, without compromising image quality.
authors.affiliation: Department of Radiology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing, China.
authors.forename: L-P
authors.initials: LP
authors.lastname: Qi
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.forename: Y-L
authors.initials: YL
authors.lastname: Li
authors.forename: X-T
authors.initials: XT
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: Y-S
authors.initials: YS
authors.lastname: Sun
authors.forename: X-P
authors.initials: XP
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D013902:Radiography, Thoracic / Q000379:methods*; D059629:Signal-To-Noise Ratio; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult