title: Gamma knife radiosurgery of recurrent atypical neurocytoma. Case report and review of the literature.
abstract: OBJECTIVE
  The goal of this work was to demonstrate the efficacy of stereotactic gamma knife radiosurgery (GKRS) for the treatment of neurocytoma by means of a case report and a comprehensive literature review.
  
  
  METHODS
  A locally recurrent atypical neurocytoma in the area of the left third ventricle thalamic wall occurring 7 years after primary microsurgical resection in a 59-year old woman was treated by GKRS. A marginal dose of 17 Gy was delivered to the surrounding 50% isodose. At the last follow-up, 82 months after radiosurgery, the tumor was locally controlled. For the literature review, computerized bibliographic searches of Pubmed were supplemented with hand searches of reference lists and abstracts of ASCO/ASTRO/ESTRO meetings.
  
  
  CONCLUSIONS
  The present case confirms the results of the literature analysis. From 1997-2011, a total of 14 series were published providing results of GKRS in 86 patients (89 lesions). The marginal doses, which have been applied, ranged from 9.6-20.0 Gy. With median follow-up intervals between 6 and 185 months, local control was 97.2% and local tumor progression of neurocytoma after GKRS was restricted to only 4 cases. In accordance with our own experience, GKRS was not associated with a relevant early or late toxicity.
  
  
  CONCLUSIONS
  GKRS can be assumed to be a safe and effective treatment modality of recurrent or residual neurocytoma.
authors.affiliation: Zentrum für Radiochirurgie und Präzisionsbestrahlung, Klinikum der J.W. Goethe Universität Frankfurt am Main, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany. robert.wolff@radio-chirurgie.de
authors.forename: R
authors.initials: R
authors.lastname: Wolff
authors.forename: V
authors.initials: V
authors.lastname: Seifert
authors.forename: A
authors.initials: A
authors.lastname: Mack
authors.forename: J
authors.initials: J
authors.lastname: Steinbach
authors.forename: C
authors.initials: C
authors.lastname: Rödel
authors.forename: R
authors.initials: R
authors.lastname: Heyd
mesh_terms: D001932:Brain Neoplasms / Q000401:mortality / Q000601:surgery*; D002551:Cerebral Ventricle Neoplasms / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008866:Microsurgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000601:surgery*; D018306:Neurocytoma / Q000401:mortality / Q000601:surgery*; D016634:Radiosurgery; D012086:Reoperation; D020542:Third Ventricle / Q000601:surgery*; D014057:Tomography, X-Ray Computed