title: Role of MicroRNAs in lung disease.
abstract: MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression. They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of lung diseases such as lung cancer, pulmonary fibrosis, asthma and chronic obstructive pulmonary disease. A better understanding of the role that miRNAs play in these diseases could lead to the development of new diagnostic and therapeutic tools. In this review, we discuss the role of some miRNAs in different lung diseases as well as the possible future of these discoveries in clinical applications.
authors.affiliation: Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Martín
authors.initials: M
authors.lastname: Angulo
authors.forename: Emilia
authors.initials: E
authors.lastname: Lecuona
authors.forename: Jacob Iasha
authors.initials: JI
authors.lastname: Sznajder
mesh_terms: D055371:Acute Lung Injury / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000235:genetics / Q000378:metabolism; D008171:Lung Diseases / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs