title: Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.
abstract: OBJECTIVE
  To assess the relation between body mass index (BMI) and short-term weight change with assisted reproductive technology (ART) outcomes.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Fertility center.
  
  
  METHODS
  A total of 170 women undergoing 233 ART cycles.
  
  
  METHODS
  Baseline BMI and short-term weight change were related to ART outcomes. Regression models accounting for repeated observations were used to adjust data for potential confounders.
  
  
  METHODS
  Peak E2 levels, oocyte yield, MII yield, fertilization rate, embryo quality, postive [beta]-hCH, clinical pregnancy and live birth rates.
  
  
  RESULTS
  Overweight and obesity were associated with lower live birth rates. The adjusted live birth rate (95% confidence interval) was 42% (28%-58%) among women with a BMI between 20 and 22.4 kg/m(2) and 23% (14%-36%) among overweight or obese women. Short-term weight loss was associated with a higher proportion of metaphase II (MII) oocytes retrieved. The adjusted proportion of MII eggs was 91% (87%-94%) for women who lost 3 kg or more and 86% (81%-89%) for women whose weight remained stable. This association was stronger among women who were overweight or obese at baseline. Short-term weight loss was unrelated to positive β-hCG, clinical pregnancy, or live birth rates.
  
  
  CONCLUSIONS
  Overweight and obesity were related to lower live birth rates in women undergoing ART. Short-term weight loss was related to higher MII yield, particularly among overweight and obese women, but unrelated to clinical outcomes.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. jchavarr@hsph.harvard.edu
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Chavarro
authors.forename: Shelley
authors.initials: S
authors.lastname: Ehrlich
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Colaci
authors.forename: Diane L
authors.initials: DL
authors.lastname: Wright
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Toth
authors.forename: John C
authors.initials: JC
authors.lastname: Petrozza
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007246:Infertility / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D054315:Oocyte Retrieval / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D050177:Overweight / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D027724:Reproductive Techniques, Assisted; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D061217:Weight Reduction Programs / Q000706:statistics & numerical data