title: Mucin as a therapeutic target in pseudomyxoma peritonei.
abstract: Pseudomyxoma peritonei (PMP) is characterized by intraperitoneal dissemination of mucinous ascites. This malignancy frequently recurs despite aggressive locoregional therapies, demonstrates chemo-insensitivity and lacks targeted therapies. This review addresses some intriguing questions in PMP; what role does mucin play in this malignancy?; what genetic alterations and dysregulated signaling pathways lead to a putative goblet cell-lineage differentiation or mucin overexpression?; are targeted therapies against known transcriptional pathways for mucin production a novel therapeutic strategy in this malignancy?
authors.affiliation: Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA. choudrymh@upmc.edu
authors.forename: Haroon A
authors.initials: HA
authors.lastname: Choudry
authors.forename: Mark E
authors.initials: ME
authors.lastname: O'Malley
authors.forename: Zong Sheng
authors.initials: ZS
authors.lastname: Guo
authors.forename: Herbert J
authors.initials: HJ
authors.lastname: Zeh
authors.forename: David L
authors.initials: DL
authors.lastname: Bartlett
mesh_terms: D020397:Goblet Cells / Q000502:physiology; D006801:Humans; D009077:Mucins / Q000502:physiology*; D010534:Peritoneal Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D011553:Pseudomyxoma Peritonei / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D015398:Signal Transduction / Q000502:physiology
chemical_list: D009077:Mucins