title: Asymmetric Friedel-Crafts alkylation of indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked bis(oxazoline) and bis(thiazoline) Zn(II) complexes.
abstract: An efficient diastereo- and enantioselective Friedel-Crafts alkylation of indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked bis(oxazoline) and bis(thiazoline) Zn(II) complexes has been developed. This asymmetric Friedel-Crafts alkylation led to medicinally privileged indolyl(nitro)chromans in good yields with high enantioselectivities (up to 95% ee) and diastereoselectivities under mild reaction conditions.
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jia
authors.forename: Wen
authors.initials: W
authors.lastname: Yang
authors.forename: Da-Ming
authors.initials: DM
authors.lastname: Du
mesh_terms: D000478:Alkylation; D001578:Benzopyrans / Q000737:chemistry*; D002384:Catalysis; D004159:Diphenylamine / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D007211:Indoles; D009574:Nitro Compounds; D010080:Oxazoles; D013844:Thiazoles; D017967:Zinc Compounds; D004159:Diphenylamine