title: Family history differs between young women with myocardial infarction and ischemic stroke: results from the RATIO case-control study.
abstract: BACKGROUND
  Family history may help in risk stratification, especially in the young. This study assesses the predictive value of a positive family history of cardiovascular disease for myocardial infarction (MI) and ischemic stroke (IS).
  
  
  RESULTS
  The RATIO study case-control study includes women with MI (N = 248), IS (N = 203) and 925 healthy matched controls. Odds ratios (ORs) and 95% confidence intervals (95%CI) were calculated with logistic regression. The risk of MI was almost fourfold increased in women with a family history positive for MI (OR 3.70, 95%CI 2.68-5.10), whereas the risk of IS was, if anything, only slightly elevated (1.25, 0.83-1.87). A family history of stroke (ischemic and hemorrhagic) was associated with a twofold increase in MI risk (2.00, 1.29-3.12), whereas the IS risk was again not clearly associated (1.37, 0.79-2.40).
  
  
  CONCLUSIONS
  The predictive value of a family history for cardiovascular disease differs between MI and IS.
authors.affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands. b.siegerink@lumc.nl
authors.forename: Bob
authors.initials: B
authors.lastname: Siegerink
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: Ale
authors.initials: A
authors.lastname: Algra
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D016017:Odds Ratio; D010375:Pedigree; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult