title: Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design.
abstract: Adipose tissue represents an abundant, accessible source of multipotent adipose-derived stromal cells (ADSCs). Animal studies have suggested that ADSCs have the potential to differentiate in vivo into endothelial cells and cardiomyocytes. This makes ADSCs a promising new cell source for regenerative therapy to replace injured tissue by creating new blood vessels and cardiomyocytes in patients with chronic ischemic heart disease. The aim of this special report is to review the present preclinical data leading to clinical stem cell therapy using ADSCs in patients with ischemic heart disease. In addition, we give an introduction to the first-in-man clinical trial, MyStromalCell Trial, which is a prospective, randomized, double-blind, placebo-controlled study using culture-expanded ADSCs obtained from adipose-derived cells from abdominal adipose tissue and stimulated with VEGF-A(165) the week before treatment.
authors.affiliation: Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, 9, Blegdamsvej, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Qayyum
authors.forename: Mandana
authors.initials: M
authors.lastname: Haack-Sørensen
authors.forename: Anders Bruun
authors.initials: AB
authors.lastname: Mathiasen
authors.forename: Erik
authors.initials: E
authors.lastname: Jørgensen
authors.forename: Annette
authors.initials: A
authors.lastname: Ekblond
authors.forename: Jens
authors.initials: J
authors.lastname: Kastrup
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology; D017202:Myocardial Ischemia / Q000628:therapy*; D012107:Research Design