title: A heme degradation enzyme, HutZ, from Vibrio cholerae.
abstract: HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1. In the presence of ascorbic acid, the HutZ-bound heme degrades via the same intermediates observed in heme oxygenase, suggesting that HutZ works as a heme degradation enzyme.
authors.affiliation: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. uchida@sci.hokudai.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uchida
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sekine
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Matsui
authors.forename: Masao
authors.initials: M
authors.lastname: Ikeda-Saito
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ishimori
mesh_terms: D001205:Ascorbic Acid / Q000737:chemistry; D001426:Bacterial Proteins / Q000235:genetics*; D006418:Heme / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D014734:Vibrio cholerae / Q000201:enzymology*
chemical_list: D001426:Bacterial Proteins; D006418:Heme; D001205:Ascorbic Acid