title: [Establishment of skin scald model in mice].
abstract: OBJECTIVE
  To establish the model of skin scald in mice for the study of skin thermal injuries.
  
  
  METHODS
  After anaesthetization mice were scalded in a 1 cm-diameter circle area on the central dorsum by boiling water at contact times: 10s or 25s. The mice were sacrificed at 1, 3, 5, 7 and 10 days after scald. The skin samples were collected and analyzed by gross and histopathological examinations.
  
  
  RESULTS
  Deep II degree thermal injury involving full-thickness skin was observed in the 10s scald group. III degree thermal injury involving full-thickness skin and the dorsal skeletal muscle was observed in the 25 s scald group.
  
  
  CONCLUSIONS
  A mouse skin scald model is established which is stable and can be used on the skin thermal injury in future research.
authors.affiliation: Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Ren
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Guan
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.forename: Wen-Xiangu
authors.initials: WX
authors.lastname: Ma
authors.forename: Shu-Tao
authors.initials: ST
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology*; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D051379:Mice; D011897:Random Allocation; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012867:Skin / Q000293:injuries* / Q000473:pathology; D013997:Time Factors