title: Intestinal stem cell function in Drosophila and mice.
abstract: Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation.
authors.affiliation: Department of Developmental Biology, UT Southwestern Medical Center, Dallas, TX 75235-9133, USA. Huaqi.Jiang@utsouthwestern.edu
authors.forename: Huaqi
authors.initials: H
authors.lastname: Jiang
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Edgar
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology*; D053595:Embryonic Stem Cells / Q000166:cytology*; D007422:Intestines / Q000166:cytology / Q000196:embryology*; D051379:Mice