title: Proton pump inhibitors: are they overutilised in clinical practice and do they pose significant risk?
abstract: Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them 'indefinitely' without appropriate indications and when they are continued after being utilised for most cases of hospital SUP. While several adverse outcomes have been linked to PPI therapy, most data are from retrospective observational studies that may be subject to confounding and bias.
authors.affiliation: Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA. jheidel@umich.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Heidelbaugh
authors.forename: D C
authors.initials: DC
authors.lastname: Metz
authors.forename: Y-X
authors.initials: YX
authors.lastname: Yang
mesh_terms: D000553:Ambulatory Care; D004812:Epidemiologic Methods; D005544:Forecasting; D005744:Gastric Acid / Q000378:metabolism / Q000502:physiology; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000378:metabolism; D006300:Health Services Misuse; D006801:Humans; D008134:Long-Term Care; D061214:Patient Safety; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000523:psychology; D013315:Stress, Psychological / Q000150:complications
chemical_list: D054328:Proton Pump Inhibitors