title: Palladium-NHC catalyzed enantioselective synthesis of fused indolines via inert C(sp(3))-H activation.
abstract: New sterically hindered chiral N-heterocyclic carbene (NHC) ligands were used in palladium catalysis to bring about a highly enantioselective C(sp(3))-H activation on the methylene site of a cycloalkane moiety. The intramolecular coupling reaction of a prochiral N-aryl-N-cycloalkyl  methyl carbamate required high temperatures (140-160 °C) and afforded highly enantioenriched trans-2,3-fused indolines.
authors.affiliation: Department of Organic Chemistry, University of Geneva, Geneva, Switzerland.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Dmitry
authors.initials: D
authors.lastname: Katayev
authors.forename: Céline
authors.initials: C
authors.lastname: Besnard
authors.forename: E Peter
authors.initials: EP
authors.lastname: Kündig