title: Serum superoxide dismutase, a potential predictor for radiation pneumonitis following chemoradiotherapy in non-small cell lung cancer patients.
abstract: OBJECTIVE
  To explore serum superoxide dismutase (SOD) for predicting radiation pneumonitis (RP) in non-small cell lung cancer patients following chemoradiotherapy.
  
  
  METHODS
  Serum levels for SOD were measured by enzyme-linked immunosorbent assays prior to radiation therapy (Pre-RT) and post 40 Gy/4 weeks during the treatment (Pos-RT).
  
  
  RESULTS
  SOD concentrations after delivery of 40 Gy/4 weeks was associated with the development of RP. The best predictive ability of SOD was observed for a cut-off value of 56 unit/ml, with a sensitivity of 0.80 (95% CI 0.28-0.99), and a specificity of 0.67 (95% CI 0.43-0.65) (p = 0.040).
  
  
  CONCLUSIONS
  Serum SOD may be a potential predictor for RP, which need to be further verified.
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, PR China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Wang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhu
authors.forename: Mingping
authors.initials: M
authors.lastname: Sun
authors.forename: Baosheng
authors.initials: B
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Wei
authors.forename: Zhongtang
authors.initials: Z
authors.lastname: Wang
authors.forename: Hongfu
authors.initials: H
authors.lastname: Sun
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D054405:Chemokine CCL3 / Q000097:blood; D059248:Chemoradiotherapy / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D053539:Keratin-19 / Q000097:blood; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D017564:Radiation Pneumonitis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D054405:Chemokine CCL3; D015850:Interleukin-6; D053539:Keratin-19; D053773:Transforming Growth Factor beta1; C102012:antigen CYFRA21.1; D018799:Intercellular Adhesion Molecule-1; D013482:Superoxide Dismutase