title: The 14-3-3σ tumor suppressor has multiple functions in ErbB2-induced breast cancer.
abstract: Ling and colleagues demonstrated that loss of the conditional 14-3-3σ allele results in accelerated HER2/ERBB2-driven mammary tumorigenesis and metastasis. This study underscores the role of 14-3-3σ as a potent tumor suppressor in ERBB2-driven tumor initiation and progression.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. nancy.hynes@fmi.ch
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Hynes
authors.forename: Tatiana
authors.initials: T
authors.lastname: Smirnova
mesh_terms: D048948:14-3-3 Proteins / Q000172:deficiency*; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
chemical_list: D048948:14-3-3 Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C499130:Sfn protein, mouse