The alcohol dehydrogenase 1C(rs698) genotype and breast cancer: a meta-analysis.
Published data regarding the association between alcohol dehydrogenase (ADH) 1C genotypes and breast cancer risk show conflicting results. The authors performed this meta-analysis on 1969 patients and 2244 controls from 4 (including 7 study populations) related case-control studies to estimate the association between ADH1C(rs698) genotyping information and breast cancer risk. According to the 6 eligible populations, the odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer risk for ADH1C (1-2) versus ADH1C (2-2) , ADH1C (1-1) versus ADH1C (2-2) genotype, and ADH1C (1) versus ADH1C (2) were 1.16 (0.95-1.42), 1.17 (0.95-1.44), and 1.05 (0.96-1.16), respectively. The OR (95% CI) for ADH1C (1-1) + ADH1C (1-2) versus ADH1C (2-2) from the 7 study populations was 1.14 (0.96-1.36). Meanwhile, genotypes of ADH1C (1-1) + ADH1C (1-2) increased the risk of breast cancer in drinkers (OR = 1.35; 95% CI = 1.03-1.76). This meta-analysis suggested that the ADH1C (1) allele might modestly influence the effect of alcohol on breast cancer but is not an independent risk factor for breast cancer. However, more restricted prospective studies are needed.
National Research Institute for Family Planning, Beijing, China.
Qunxia
Q
Mao
General Hospital of Chinese People's Liberation Army, Beijing, China.
Linggen
L
Gao
China Institute of Industrial Relations, Beijing, China.
Hongwei
H
Wang
Cardiovascular Institute and Fu Wai Hospital, Beijing, China.
Qian
Q
Wang
National Centre for Women and Children's Health, China CDC, Beijing, China zhangt2011bj@163.com.
Tong
T
Zhang
D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000453:epidemiology / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors
C420272:ADH1C protein, human; D000426:Alcohol Dehydrogenase