[Apoptosis modulation by PMA occurs independently of TsPO expression in squamous cell carcinoma cells].
Phorbol esters are known to modulate protein kinase C activity - enzyme involved in cell proliferation, differentiation and apoptosis regulation in skin cells. Besides it phorbol-12-myristate 13-acetate was shown possible to modulate promoter activity of TsPO - protein that is involved in steroidogenesis and cell proliferation regulation. Caspase-3 and TsPO expression was measured in squamous cell carcinoma cells after incubation with phorbol-12-myristate 13-acetate and ultraviolet radiation. Following alterations of TsPO and caspase-3 levels are explained by different mechanisms of regulation.
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D017209:Apoptosis / Q000187:drug effects*; D002273:Carcinogens / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D018079:Receptors, GABA / Q000096:biosynthesis*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D002273:Carcinogens; D009363:Neoplasm Proteins; D018079:Receptors, GABA; C499229:TSPO protein, human; D011493:Protein Kinase C; C505407:CASP3 protein, human; D053148:Caspase 3; D013755:Tetradecanoylphorbol Acetate