Low dose pioglitazone does not affect bone formation and resorption markers or bone mineral density in streptozocin-induced diabetic rats.
Our study aims to investigate the effect of a low-dose pioglitazone regimen on bone mineral density and bone formation-resorption markers in control and diabetic rats. Wistar rats were divided into 4 groups: non-diabetic controls, control rats receiving pioglitazone (3 mg/kg), streptozocin-treated diabetic rats (50 mg/kg), diabetic rats treated with pioglitazone (3 mg/kg). The duration of the experiment was 8 weeks. Diabetes in our rats was associated with weight loss, increased urinary calcium excretion and reduced plasma osteocalcin levels. Diabetes mellitus did not affect bone mineral density. Pioglitazone administration had no impact on bone formation and resorption markers levels and did not modify bone mineral density in the four studied groups. Pioglitazone at the 3 mg/kg dose was not associated with significant skeletal complications in our experimental model.
A'Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. tsirella@yahoo.fr
E
E
Tsirella
T
T
Mavrakanas
O
O
Rager
S
S
Tsartsalis
K
K
Kallaras
B
B
Kokkas
M
M
Mironidou-Tzouveleki
D000469:Alkaline Phosphatase / Q000652:urine; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000097:blood / Q000503:physiopathology / Q000652:urine; D002118:Calcium / Q000652:urine; D024042:Collagen Type I / Q000652:urine; D003404:Creatinine / Q000652:urine; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology / Q000652:urine; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000502:physiology; D010455:Peptides / Q000652:urine; D000077205:Pioglitazone; D051381:Rats; D017208:Rats, Wistar; D045162:Thiazolidinediones / Q000494:pharmacology*
D015415:Biomarkers; D024042:Collagen Type I; D007004:Hypoglycemic Agents; D010455:Peptides; D045162:Thiazolidinediones; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium; D000077205:Pioglitazone