[Expression of the genes Egf and Egfr in renal tissue of the hypertensive rats of the ISIAH strain].
Activation of the epidermal growth factor receptors (EGFR) plays an important role in the regulation of the kidney blood circulation and ion transport. The mRNA content of the epidermal growth factor (Egf) and its receptor (Egfr) genes were studied in the cortical and medullar parts of the kidney of rats with stress sensitive arterial hypertension (ISIAH strain) and normotensive WAG rats. There were no differences in the Egf expression between the rat strains at rest and under emotional stress in both the cortical and medullary kidney zones. As for Egfr transcription, it was significantly higher in the cortical and medullary parts of the ISIAH kidneys at rest as compared to the control WAG. Emotional stress induced no significant changes in the Egfr transcription in the cortical kidney parts of both rat strains. But prominent enhancement of Egfr transcription after emotional stress was observed in the kidney medulla of the WAG rats: it became the same as in the ISIAH rats at rest. It was suggested that the stress hormones might be involved in the regulation of Egfr transcription, and this connection between stress and Egfr gene activity might play a significant role in the kidney involvement in pathogenesis of stress sensitive arterial hypertension.
T O
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Pyl'nik
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OE
Redina
S E
SE
Smolehskaia
L N
LN
Ivanova
A L
AL
Markel'
D000302:Adrenal Cortex / Q000378:metabolism*; D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006973:Hypertension / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D013315:Stress, Psychological
D012333:RNA, Messenger; D004815:Epidermal Growth Factor; D066246:ErbB Receptors