DNA synthesis as a therapeutic target: the first 65 years.
Department of Biochemistry and Biophysics, 2011 ALS, Oregon State University, Corvallis, OR 97331-7305, USA. mathewsc@onid.orst.edu
Christopher K
CK
Mathews
D000630:Aminopterin / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000266:history / Q000627:therapeutic use*; D004261:DNA Replication / Q000187:drug effects*; D005472:Fluorouracil / Q000378:metabolism; D005492:Folic Acid / Q000031:analogs & derivatives; D005493:Folic Acid Antagonists / Q000494:pharmacology; D049673:History, 20th Century; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000266:history; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D000630:Aminopterin; D005472:Fluorouracil; D006918:Hydroxyurea; D008727:Methotrexate