Enantioseparation of racemic mixtures based on solvent sublation.
A method of solvent sublation was developed for the enantioseparation of racemic ofloxacin (rac Oflx) and racemic tryptophan (rac Trp). In this method, dibenzoyl-L-tartaric acid (L-DBTA) and di-(2-ethylhexyl) phosphoric acid (D2EHPA) and sodium lauryl sulfate (SDS) were used as chiral coextractants and foamer, respectively. Several important parameters influencing the separation performances, such as pH in aqueous phase, concentrations of rac mixtures, L-DBTA, D2EHPA, and SDS, were investigated. Under the optimal operation conditions, the enantiomeric excess and enantioselectivity were 60.08% and 5.58 for Oflx and 65.09% and 6.31 for Trp, respectively. The yields of D-enantiomer and L-enantiomer were 34.23% and 8.54% for Oflx and 18.59% and 3.93% for Trp, respectively. The results suggest that the enantioselectivities have been enhanced compared with the traditional chiral extraction. This technique is an efficient chiral separation method, with many advantages such as low expenditures of organic solvent, low consumption of chiral extractant, and easy realization of multistage operation.
School of Chemistry and Chemical Engineering, Central South University, Changsha, China.
Feipeng
F
Jiao
Weijie
W
Yang
Fen
F
Wang
Lingxing
L
Tian
Lin
L
Li
Xiaoqing
X
Chen
Kelang
K
Mu
D000327:Adsorption; D005591:Chemical Fractionation / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D010755:Organophosphates / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
D010755:Organophosphates; D012997:Solvents; D013644:Tartrates; D014867:Water; C007377:di-2-(ethylhexyl)phosphoric acid; D012967:Sodium Dodecyl Sulfate; C435201:2,3-bis(benzoyloxy)tartaric acid