Pharmacogenomic biomarkers in dermatologic drugs.
Biomarkers are becoming increasingly important when considering the efficacy, toxicology, mechanism of action, and risk of adverse events in certain drugs. As availability of bio-genomic information increases, more treatments can be tailored to specific individuals, with a net effect of improved health outcomes. Many dermatology drugs have pharmacogenomic information on their labels. Knowing the risks and benefits associated with genomic biomarkers can aid physicians to make more knowledgeable decisions when identifying treatments for their patients.
Department of Dermatology, University of California San Francisco , San Francisco , USA.
Nava Pincus
NP
Greenfield
Howard
H
Maibach
D000736:Androstenes / Q000009:adverse effects / Q000378:metabolism; D001189:Aryl Hydrocarbon Hydroxylases / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism*; D002738:Chloroquine / Q000009:adverse effects / Q000378:metabolism; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000172:deficiency / Q000378:metabolism; D003622:Dapsone / Q000009:adverse effects / Q000378:metabolism; D003879:Dermatologic Agents / Q000009:adverse effects / Q000378:metabolism*; D054067:Dihydropyrimidine Dehydrogenase Deficiency / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000378:metabolism; D005472:Fluorouracil / Q000009:adverse effects / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000378:metabolism; D006801:Humans; D009281:Naphthalenes / Q000009:adverse effects / Q000378:metabolism; D011319:Primaquine / Q000009:adverse effects / Q000378:metabolism; D011812:Quinuclidines / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000378:metabolism; D000077291:Terbinafine; D013876:Thiophenes / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000378:metabolism
D000736:Androstenes; D015415:Biomarkers; D003879:Dermatologic Agents; D009281:Naphthalenes; D011812:Quinuclidines; D013876:Thiophenes; C534342:drospirenone and ethinyl estradiol combination; D004997:Ethinyl Estradiol; D002738:Chloroquine; D003622:Dapsone; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6; D000077291:Terbinafine; C059240:cevimeline; D011319:Primaquine; D005472:Fluorouracil