Cutting edge in medical management of cutaneous oncology.
Traditional chemotherapy has resulted in only a modest response, if any, for the 3 most common cutaneous malignancies of basal cell carcinoma, squamous cell carcinoma, and melanoma. Recent advances in understanding of the defects in the pathways driving tumorigenesis have changed the way that we think of these cancers and paved the way to targeted therapy for specific tumors. In this review, we will introduce the novel systemic treatments currently available for these cancers in the context of what is understood about the tumor pathogenesis. We will also introduce ongoing studies that will hopefully broaden our options for highly effective and tolerable treatment.
Department of Dermatology, University of California at San Francisco, San Francisco, CA 94143, USA. arrons@derm.ucsf.edu
Kim
K
Chong
Adil
A
Daud
Susana
S
Ortiz-Urda
Sarah T
ST
Arron
D002280:Basal Cell Carcinoma / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008545:Melanoma / Q000628:therapy*; D058990:Molecular Targeted Therapy / Q000379:methods*; D012878:Skin Neoplasms / Q000628:therapy*