Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity.
It has been recognised recently that obese individuals have lower concentrations of micronutrients and this may affect the concentrations of inflammatory cytokines. A cross-sectional study was carried out to evaluate the association of specific micronutrients' status with chronic inflammation caused by obesity in 280 women (36·1 (SD 7·5) years) from seven rural communities in Mexico. Measurements of weight, height and waist circumference were made on all women and body composition was determined by dual-energy X-ray absorptiometry. Concentrations of the cytokines IL-1, TNF-α, IL-6, IL-10 and IL-12, lipid profile, and the micronutrients Zn and vitamins A, C and E were determined in fasting blood samples. Ordered logistic regression models were used to determine associations between categorised cytokine levels and micronutrients. It was found that 80% of women were overweight or obese, and had significantly higher concentrations of C-reactive protein than normal-weight women (P= 0·05). The risk of higher levels of TNF-α, IL-6, IL-10 and IL-12 was reduced significantly among women with higher Zn concentrations (OR 0·63, 95% CI 0·42, 0·96, P= 0·03; OR 0·57, 95% CI 0·39, 0·86, P= 0·025; OR 0·63, 95% CI 0·41, 0·96, P= 0·04; OR 0·62, 95% CI 0·41, 0·95, P= 0·03, respectively). Higher concentrations of vitamin A were slightly associated with reduced risks of higher levels of IL-1 and IL-12 (OR 0·97, 95% CI 0·95, 0·99, P= 0·03; OR 0·97, 95% CI 0·94, 0·99, P= 0·03, respectively); when adjusting for BMI, this association was lost. No associations were found between vitamin C or vitamin E:lipids concentrations and inflammatory cytokines. In conclusion, higher Zn concentrations are associated with reduced risks of higher concentration of inflammation markers in a population of women with a high prevalence of obesity.
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av de la Ciencia S/N, Juriquilla, Querétaro, Qro, CP 76230, Mexico.
Gerardo
G
Zavala
School of Population Health, University of Queensland, Queensland, Australia.
Kurt Z
KZ
Long
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av de la Ciencia S/N, Juriquilla, Querétaro, Qro, CP 76230, Mexico.
Olga P
OP
García
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av de la Ciencia S/N, Juriquilla, Querétaro, Qro, CP 76230, Mexico.
María del Carmen
Mdel C
Caamaño
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av de la Ciencia S/N, Juriquilla, Querétaro, Qro, CP 76230, Mexico.
Tania
T
Aguilar
CICATA, IPN, Querétaro, Qro, Mexico.
Luis M
LM
Salgado
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Av de la Ciencia S/N, Juriquilla, Querétaro, Qro, CP 76230, Mexico.
Jorge L
JL
Rosado
D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016015:Logistic Models; D008800:Mexico / Q000453:epidemiology; D018977:Micronutrients / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D015995:Prevalence; D012424:Rural Population; D055105:Waist Circumference
D016207:Cytokines; D018977:Micronutrients; D002097:C-Reactive Protein