Isolation of spirastrellolides A and B from a marine sponge Epipolasis sp. and their cytotoxic activities.
Spirastrellolides A (1) and B (3) have been isolated as free acids from a marine sponge Epipolasis sp. collected in the East China Sea. These compounds had been isolated from the Caribbean marine sponge Spirastrella coccinea after conversion to the methyl ester. We examined the cytotoxic activities of 1 and 3 and found that the activities of the free acids are comparable to those of the corresponding methyl esters.
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657, Japan.
Masashi
M
Suzuki
Reiko
R
Ueoka
Kentaro
K
Takada
Shigeru
S
Okada
Susumu
S
Ohtsuka
Yuji
Y
Ise
Shigeki
S
Matsunaga
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017691:Caribbean Region; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; C519027:spirastrellolide B