Going forward: Increasing the accessibility of imaging mass spectrometry.
The driving force behind the high and increasing popularity of imaging mass spectrometry is its demonstrated potential for the determination of new diagnostic/prognostic biomarkers and its ability to simultaneously trace the distributions of pharmaceuticals and their metabolites in tissues without the need to develop expensive radioactively-labeled analogues. Both of these applications would benefit from standardized methods, for the development of novel MS-based molecular histology tests and governmental-approved MS-based assays for pharmaceutical development. In addition, the broader scientific community would benefit from the increased accessibility of the technique. Currently imaging MS studies are individual endeavors, utilizing the individual expertise and infrastructure of a single laboratory and their immediate collaborators. A wide array of tissue preparation, data acquisition and data analysis techniques has been developed but lacks an international collaborative structure and data sharing capabilities. Such a collaborative framework would enable methodological exchange and detailed comparisons of analytical capabilities, to explore synergies between the different methods and result in the development of robust standardized methods. Here we describe the activities of a new European imaging MS network that will explicitly compare and contrast existing methods to provide best practice guidelines for the entire healthcare research community.
Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: l.a.mcdonnell@lumc.nl.
Liam A
LA
McDonnell
FOM Institute AMOLF, Science Park 104, Amsterdam, The Netherlands.
Ron M A
RMA
Heeren
Department of Pharmaceutical Biosciences, Medical Mass Spectrometry, Uppsala University, Uppsala, Sweden.
Per E
PE
Andrén
Novartis Institutes of BioMedical Research, Analytical Sciences, Basel, Switzerland.
Markus
M
Stoeckli
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Garry L
GL
Corthals
D003299:Cooperative Behavior; D003952:Diagnostic Imaging / Q000379:methods / Q000592:standards / Q000639:trends*; D006297:Health Services Accessibility / Q000458:organization & administration / Q000639:trends; D006301:Health Services Needs and Demand; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods / Q000592:standards / Q000639:trends*; D008954:Models, Biological; D017410:Practice Guidelines as Topic; D012015:Reference Standards