Hsp 70, hsCRP and oxidative stress in patients with acute coronary syndromes.
Acute coronary syndromes (ACS) like unstable angina (UA) and acute myocardial infarction (AMI) can lead to the morbidity and mortality. The diagnosis and management of patients with ACS in the earliest times after symptom onset are considerably important in the emergency service. Study aimed to investigate the serum levels of heat shock protein 70 (Hsp 70), high sensitivity C-reactive protein (hsCRP), total creatine kinase (CK) activity, creatine kinase MB (CK-MB), cardiac troponin I (cTnI), leukocyte count (WBCs) and markers of oxidative stress in the first hours of ACS and to view their diagnostic values. 70 patients with ACS after admission and 20 sex-matched healthy controls were included in this study. Serum Hsp 70, hsCRP, CK, CK-MB, cTnI, protein carbonyls, malondialdehyde as well as whole blood WBCs were measured. The level of hsCRP was statistically higher in patients with AMI and UA than that of control group (p<0.001). WBCs and oxidized protein levels were higher in AMI than in UA and control groups. cTnI was related to CK-MB in AMI and UA groups (r=0.731, r=0.806, p<0.001, respectively) and also related with hsCRP in UA group (r=0.824, p<0.001). The mean Hsp 70 level was higher by 32.2% in AMI and 12.7% in UA patients compared to control subjects. hsCRP may have a role in the inflammatory response after ACS. In addition to cTnI and CK-MB, WBCs and hsCRP may be useful as a marker for the identification of ACS patients with chest pain in early diagnosing.
Department of Biochemistry, School of Medicine, Ondokuz Mayıs University 55139 Samsun, Turkey.
Ramazan
R
Amanvermez
Ethem
E
Acar
Murat
M
Günay
Ahmet
A
Baydın
Türker
T
Yardan
Yüksel
Y
Bek
D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000378:metabolism*; D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000378:metabolism; D019540:Area Under Curve; D015415:Biomarkers; D002097:C-Reactive Protein / Q000096:biosynthesis*; D002637:Chest Pain; D003402:Creatine Kinase / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007958:Leukocyte Count; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation / Q000502:physiology; D012372:ROC Curve; D012307:Risk Factors; D019210:Troponin I / Q000378:metabolism
D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D019210:Troponin I; D008315:Malondialdehyde; D002097:C-Reactive Protein; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form