[Significance of pain sensitivity for the resistance to immobilization stress].
The effects of immobilization stress (immobilization on back within 4 h) on the functional indexes of Wistar male rats differing with pain sensitivity in the tail-flick test were studied. The acute immobilization stress in rats with high pain sensitivity compared with low pain sensitivity animals produced the most changes of the main functional systems. The high pain sensitivity rats demonstrated more significant hypotension, bradicardia, temperature shift, decrease of breath frequency and oxygen consumption, acid-alkaline equilibrium disorders with lactate acidosis signs. Therefore, the rats with low pain sensitivity possess the high resistance to acute stress exposure in comparison with high pain sensitivity animals. This confirms the important significance of individual pain sensitivity for the formation of stress resistance.
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Zarubina
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Shabanov
D000818:Animals; D007103:Immobilization / Q000009:adverse effects*; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological