Keratocystic odontogenic tumors: predictive factors of recurrence by Ki-67 and AgNOR labelling.
OBJECTIVE
The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers.


METHODS
22 KCOTs were evaluated retrospectively. The actual proliferative activity of the KCOT was measured by Ki-67 labelling index and argyrophilic nucleolar organizing regions AgNOR count per nucleus.


RESULTS
Recurrence occurred in 3 patients (13.6%) during the follow-up period (mean follow-up, 37.8 months) The Ki-67 and AgNOR counts were significantly higher in the recurrent lesions comparing to the non-recurrent lesions. (p=0,045; p=0,049) The correlation between Ki-67 and AgNOR counts was found to be positive (r=0,853 p=0,0001).


CONCLUSIONS
Within the limit of the present study, it is thought that Ki-67 and AgNOR might be helpful as a prognostic marker for the recurrences of KCOTs. These markers reinforced the meaning of the new classification of the lesion as an odontogenic tumor. Enucleation with curettage or decompression following enucleation with curettage is a simple and appropriate surgical model for the treatment of KCOT despite the relative high recurrence rate. On the other hand, the conservative treatment can be chosen only if there is no coronoid invasion, no interruptive cortical lysis and no tissular invasion.
Istanbul University, Dentistry Faculty, Department of Oral and Maxillofacial Surgery, Istanbul, Turkey. fselvi@istanbul.edu.tr
Firat
F
Selvi
Merva Soluk
MS
Tekkesin
Sirmahan
S
Cakarer
S Cemil
SC
Isler
Cengizhan
C
Keskin
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000378:metabolism*; D009807:Odontogenic Cysts / Q000378:metabolism* / Q000473:pathology*; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult
D019394:Ki-67 Antigen