Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study.
BACKGROUND
The countries of Central and Eastern Europe have among the highest worldwide rates of renal cell cancer (RCC). Few studies have examined whether genetic variation in xenobiotic metabolic pathway genes may modify risk for this cancer.


METHODS
The Central and Eastern Europe Renal Cell Cancer study was a hospital-based case-control study conducted between 1998 and 2003 across seven centers in Central and Eastern Europe. Detailed data were collected from 874 cases and 2053 controls on demographics, work history, and occupational exposure to chemical agents. Genes [cytochrome P-450 family, N-acetyltransferases,
quinone oxidoreductase I (NQO1), microsomal epoxide hydrolase (mEH), catechol-O-methyltransferase (COMT), uridine diphosphate-glucuronosyltransferase (UGT)] were selected for the present analysis based on their putative role in xenobiotic metabolism. Haplotypes were calculated using fastPhase. Odds ratios and 95% confidence intervals were estimated by unconditional logistic regression adjusted for country of residence, age, sex, smoking, alcohol intake, obesity, and hypertension.


RESULTS
We observed an increased risk of RCC with one SNP. After adjustment for multiple comparisons it did not remain significant. Neither NAT1 nor NAT2 slow acetylation was associated with disease.


CONCLUSIONS
We observed no association between this pathway and renal cell cancer.
International Agency for Research on Cancer Lyon, France.
Julia E
JE
Heck
Lee E
LE
Moore
Yuan-Chin A
YC
Lee
James D
JD
McKay
Rayjean J
RJ
Hung
Sara
S
Karami
Valérie
V
Gaborieau
Neonila
N
Szeszenia-Dabrowska
David G
DG
Zaridze
Anush
A
Mukeriya
Dana
D
Mates
Lenka
L
Foretova
Vladimir
V
Janout
Helena
H
Kollárová
Vladimir
V
Bencko
Nathaniel
N
Rothman
Paul
P
Brennan
Wong-Ho
WH
Chow
Paolo
P
Boffetta