Peripheral and central bone mineral density in Charcot's neuroarthropathy compared in diabetic and nondiabetic populations.
BACKGROUND
This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared bone density with the time from onset of Charcot's neuroarthropathy (CN) in patients with unilateral, nonoperative, reconstructive-stage CN. The final purpose was to investigate the role that sex, age, and serum vitamin D level may have in osseous recovery.


METHODS
Thirty-three individuals were divided into three groups: controls and patients with diabetes mellitus with and without CN. Peripheral instantaneous x-ray imaging and dual-energy x-ray absorptiometry were performed.


RESULTS
The calcaneal BMD of patients with diabetes mellitus and CN was lower than that of the control group (P < .01) but was not significantly lower than that of patients with diabetes mellitus alone. There was no statistically significant difference in lumbar T-scores between groups. Women demonstrated lower BMD than did men (P = .02), but patients 60 years and older did not demonstrate significantly lower BMD than did patients younger than 60 years (P = .135). A negative linear relationship was demonstrated between time and BMD in patients with CN.


CONCLUSIONS
The results of this study suggest that lumbar BMD does not reflect peripheral BMD in patients with diabetes mellitus and reconstructive-stage CN. This study has clinical implications when reconstructive osseous surgery is planned in patients with CN.
Foot and Ankle Center of Nebraska, Omaha, NE, USA. robert.m.greenhagen@gmail.com
Robert M
RM
Greenhagen
Dane K
DK
Wukich
Rachel H
RH
Jung
Vassilios
V
Vardaxis
Robert M
RM
Yoho
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001177:Arthropathy, Neurogenic / Q000503:physiopathology*; D015519:Bone Density / Q000502:physiology*; D002111:Calcaneus / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014807:Vitamin D / Q000097:blood
D014807:Vitamin D