Catalytic asymmetric Mannich-type reactions of α-cyano α-sulfonyl carbanions.
An efficient asymmetric Mannich-type reaction of α-cyano α-sulfonyl carbanions has been achieved by exploiting the structural modularity and anion-recognition ability of chiral 1,2,3-triazolium ions. This protocol has proven to be applicable to a variety of N-Boc imines and cyanosulfones, affording β-amino α-cyanosulfones in excellent yields with high stereoselectivities.
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, 464-8603, Japan.
Kohsuke
K
Ohmatsu
Ayano
A
Goto
Takashi
T
Ooi