Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA UK.
Marina
M
Demetriades
Ivanhoe K H
IK
Leung
Rasheduzzaman
R
Chowdhury
Mun Chiang
MC
Chan
Michael A
MA
McDonough
Kar Kheng
KK
Yeoh
Ya-Min
YM
Tian
Timothy D W
TD
Claridge
Peter J
PJ
Ratcliffe
Esther C Y
EC
Woon
Christopher J
CJ
Schofield
D001897:Boronic Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004791:Enzyme Inhibitors / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006801:Humans; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010084:Oxidation-Reduction; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry
D001897:Boronic Acids; D004791:Enzyme Inhibitors; D004952:Esters; C490190:EGLN1 protein, human; D011393:Procollagen-Proline Dioxygenase; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases