Poly(2-ethyl-2-oxazoline) as alternative for the stealth polymer poly(ethylene glycol): comparison of in vitro cytotoxicity and hemocompatibility.
Limitations of PEG in drug delivery have been reported from clinical trials. PEtOx (0.4-40 kDa) as alternative is synthesized by a living, microwave-assisted polymerization, and is directly compared to PEG of similar molar mass regarding cytotoxicity and hemocompatibility. In short-term treatments, both types of polymers are well tolerated even at high concentrations. Moderate concentration and molar mass dependent cytotoxic effects occurred only after long-term incubation at concentrations higher than therapeutic doses. PEtOx possesses not only an easy route of synthesis and beneficial physicochemical characteristics such as low viscosity and high stability, which are advantageous over PEG, but additionally in vitro toxicology comparable to PEG.
Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich-Schiller University Jena, Jena, Germany.
Marius
M
Bauer
Christian
C
Lautenschlaeger
Kristian
K
Kempe
Lutz
L
Tauhardt
Ulrich S
US
Schubert
Dagmar
D
Fischer
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D051379:Mice; D008872:Microwaves; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D058105:Polymerization; D014783:Viscosity
D001672:Biocompatible Materials; D004337:Drug Carriers; D011073:Polyamines; C511916:poly(2-ethyl-2-oxazoline); D011092:Polyethylene Glycols; D007770:L-Lactate Dehydrogenase