Effects of aerobic exercise on chronic allergic airway inflammation and remodeling in guinea pigs.
We evaluated the effects of aerobic exercise (AE) on airway inflammation, exhaled nitric oxide levels (ENO), airway remodeling, and the expression of Th1, Th2 and regulatory cytokines in a guinea pig asthma model. Animals were divided into 4 groups: non-trained and non-sensitized (C), non-sensitized and AE (AE), ovalbumin-sensitized and non-trained (OVA), and OVA-sensitized and AE (OVA+AE). OVA inhalation was performed for 8 weeks, and AE was conducted for 6 weeks beginning in the 3rd week of OVA sensitization. Compared to the other groups, the OVA+AE group had a reduced density of eosinophils and lymphocytes, reduced expression of interleukin (IL)-4 and IL-13 and an increase in epithelium thickness (p<0.05). AE did not modify airway remodeling or ENO in the sensitized groups (p>0.05). Neither OVA nor AE resulted in differences in the expression of IL-2, IFN-γ, IL-10 or IL1-ra. Our results show that AE reduces the expression of Th2 cytokines and allergic airway inflammation and induces epithelium remodeling in sensitized guinea pigs.
Department of Physical Therapy, School of Medicine, University of Sao Paulo, Av. Dr Arnaldo, 455, Room 1210, 01246-903 São Paulo, SP, Brazil.
Clarice R
CR
Olivo
Rodolfo P
RP
Vieira
Fernanda M
FM
Arantes-Costa
Adenir
A
Perini
Milton Arruda
MA
Martins
Celso Ricardo Fernandes
CR
Carvalho
D056151:Airway Remodeling / Q000502:physiology*; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010805:Physical Conditioning, Animal