Carryover of maduramicin from feed containing cross-contamination levels into eggs of laying hens.
Maduramicin is a coccidiostat authorized as feed additive in the European Union for chickens and turkeys for fattening but not for laying hens, considering the risk of residues in eggs. The unavoidable cross-contamination of non-target feed with coccidiostats is regulated by Commission Directive 2009/8/EC and resulting carry-over in food by Commission Regulation (EC) No. 124/2009. To verify the compliance of the maximum levels for maduramicin in feed (50 μg/kg) and eggs (2 μg/kg), the carry-over from feed into eggs was investigated. Diets containing 10, 30, and 50 μg of maduramicin/kg of feed were fed to laying hens. Feed, egg white, and yolk were analyzed by LC-MS/MS. Maduramicin residues were only detected in in egg yolk. Feeding the 10 μg/kg maduramicin diet resulted in maduramicin concentrations up to 2.5 μg/kg in whole eggs, already exceeding the maximum level. A carry-over rate of 8% maduramicin from feed into eggs was calculated.
Federal Institute for Risk Assessment, Berlin, Germany. dorina.bodi@bfr.bund.de
Dorina
D
Bodi
Hildburg
H
Fry
Helmut
H
Schafft
Monika
M
Lahrssen-Wiederholt
Angelika
A
Preiss-Weigert
D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D002645:Chickens; D003049:Coccidiostats / Q000032:analysis*; D004530:Egg Yolk / Q000737:chemistry; D004531:Eggs / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D007783:Lactones / Q000032:analysis; D010573:Pesticide Residues / Q000032:analysis*; D015203:Reproducibility of Results
D003049:Coccidiostats; D007783:Lactones; D010573:Pesticide Residues; C018091:maduramicin