[Digestive forms of Chagas disease and carcinogenesis: a study of association].
The authors analyze the relation between gastrointestinal carcinogenesis and Chagas disease, based on detailed review of the literature. To this end, epidemiological, experimental and human material pathology description studies have been selected. The article discusses the possibility of protection being afforded by not fully known morphokinetic cellular, immune and neuroendocrine factors that would be secondary to plexus degeneration. Also aspects related to the parasite-host interaction from the viewpoint of epithelial modulation of colonic mucosa and its antitumor implications are presented. Finally, it exposes the pathophysiological mechanism of esophageal cancer development in patients with mega-organ. In conclusion, chagasic colopathy, especially the intrinsic neuronal damage, is a study model that can contribute to the understanding of colorectal carcinogenesis.
Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, BR.
Caio Eduardo
CE
Gullo
Cássia Fernanda
CF
Estofolete
Cristiane Damas
CD
Gil
Adriana Borgonovi
AB
Christiano
João Gomes
JG
Netinho
D014355:Chagas Disease / Q000150:complications*; D005767:Gastrointestinal Diseases / Q000469:parasitology*; D005770:Gastrointestinal Neoplasms / Q000469:parasitology*; D006801:Humans