FeCl3 promoted highly regioselective [3 + 2] cycloaddition of dimethyl 2-vinyl and aryl cyclopropane-1,1-dicarboxylates with aryl isothiocyanates.
A FeCl(3) promoted [3 + 2] annulation of dimethyl 2-vinyl and arylcyclopropane-1,1-dicarboxylate with aryl isothiocyanates has been developed to give pyrrolidine-2-thiones in good yields with high regioselectivity.
Shanghai Institute of Materia Medica, Shanghai, 201203, P. R. China.
Huina
H
Wang
Wei
W
Yang
Hong
H
Liu
Wei
W
Wang
Hao
H
Li
D002264:Carboxylic Acids / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry
D002264:Carboxylic Acids; D002712:Chlorides; D003521:Cyclopropanes; D005290:Ferric Compounds; D017879:Isothiocyanates; D011759:Pyrrolidines; D013871:Thiones; C030797:cyclopropane; C024555:ferric chloride