Waning population immunity to measles in Taiwan.
To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (≥ 35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older.
Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, 333 Taoyuan, Taiwan.
Chih-Jung
CJ
Chen
Ping-Ing
PI
Lee
Yu-Chia
YC
Hsieh
Po-Yen
PY
Chen
Yu-Huai
YH
Ho
Chee-Jen
CJ
Chang
Ding-Ping
DP
Liu
Feng-Yee
FY
Chang
Cheng-Hsun
CH
Chiu
Yhu-Chering
YC
Huang
Chin-Yun
CY
Lee
Tzou-Yien
TY
Lin
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D032521:Immunity, Herd; D007223:Infant; D008297:Male; D008457:Measles / Q000453:epidemiology*; D008458:Measles Vaccine / Q000627:therapeutic use; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
D000914:Antibodies, Viral; D008458:Measles Vaccine