Electrophysiological-metabolic modeling of microbes: applications in fuel cells and environment analysis.
A formalism for simulating coupled metabolic and electrophysiological processes is presented. The resulting chemical kinetic and electrophysiological equations are solved numerically to create a cell simulator. Metabolic features of this simulator were adapted from Karyote, a multi-compartment biochemical cell modeling simulator. We present the mathematical formalism and its computational implementation as an integrated electrophysiological-metabolic model. Applications to Geobacter sulfurreducens in the environment and in a fuel cell are discussed.
Department of Chemistry, Prairie View A&M University, Prairie View, TX, USA.
Max
M
Fontus
Peter
P
Ortoleva
D000465:Algorithms; D001674:Bioelectric Energy Sources; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods*; D045302:Geobacter / Q000378:metabolism; D008962:Models, Theoretical