Metabolic assessment of elderly men with urolithiasis.
OBJECTIVE
To assess the presence of metabolic disorders in elderly men with urolithiasis.


METHODS
We performed a case-control study. The inclusion criteria were as follows: (1) men older than 60 years of age and either (2) antecedent renal colic or an incidental diagnosis of urinary lithiasis after age 60 (case arm) or (3) no antecedent renal colic or incidental diagnosis of urolithiasis (control arm). Each individual underwent an interview, and those who were selected underwent all clinical protocol examinations: serum levels of total and ionized calcium, uric acid, phosphorus, glucose, urea, creatinine and parathyroid hormone, urine culture, and analysis of 24-hour urine samples (levels of calcium, citrate, creatinine, uric acid and sodium, pH and urine volume). Each case arm patient underwent two complete metabolic urinary investigations, whereas each control arm individual underwent one examination. ClinicalTrials.gov: NCT01246531.


RESULTS
A total of 51 subjects completed the clinical investigation: 25 in the case arm and 26 in the control arm. In total, 56% of the case arm patients had hypocitraturia (vs. 15.4% in the control arm; p = 0.002). Hypernatriuria was detected in 64% of the case arm patients and in 30.8% of the controls (p = 0.017).


CONCLUSIONS
Hypocitraturia and hypernatriuria are the main metabolic disorders in elderly men with urolithiasis.
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil. celso.freitas@sbu.org.br
Celso Heitor
CH
Freitas Junior
Eduardo
E
Mazzucchi
Alexandre
A
Danilovic
Artur Henrique
AH
Brito
Miguel
M
Srougi
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D002951:Citrates / Q000652:urine*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis*; D012964:Sodium / Q000652:urine*; D014545:Urinary Calculi / Q000652:urine; D052878:Urolithiasis / Q000150:complications / Q000652:urine*
D002951:Citrates; D012964:Sodium