[Monocytic chemotaxic protein-1 and beta2-microglobulin: a role in estimation of renal parenchyma damage in surgical treatment of nephrolithiasis].
To estimate renal damage and intensity of tubulointerstitial fibrosis basing on the data of modern molecular markers in surgical treatment of nephrolithiasis, we examined the results of surgical treatment of 200 nephrolithiasis patients divided into 5 groups by the method of surgery. We estimated content of molecular mediators of nephrofibrosis in the urine and severity of renal dysfunction. We were the first to follow up urinary excretion of proinflammatory and profibrotic monocytic chemoattractant protein-1 (MCP-1) and low-molecular protein beta-2-microglobulin which is a reliable indicator of tubular impairment. Our study demonstrated the highest efficacy and low traumatic risk of percutaneous nephrolithotripsy. We determined diagnostic levels of the studied laboratory indices which can be used for identification of impacts on nephrofibrosis processes.
P V
PV
Glybochko
A N
AN
Rossolovskiĭ
A N
AN
Ponukalin
B I
BI
Bliumberg
O L
OL
Berezinets
D015415:Biomarkers / Q000652:urine; D018932:Chemokine CCL2 / Q000652:urine*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D053040:Nephrolithiasis / Q000473:pathology / Q000601:surgery* / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D001613:beta 2-Microglobulin