Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease.
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NFκB and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.
Department of Diagnosis and Surgery, School of Dentistry, UNESP-Univ. Estadual Paulista, Araraquara, SP, Brazil.
João Antonio Chaves de
JA
Souza
Carlos
C
Rossa
Gustavo Pompermaier
GP
Garlet
Andressa Vilas Boas
AV
Nogueira
Joni Augusto
JA
Cirelli
D018441:Biofilms; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology / Q000627:therapeutic use*; D053612:Janus Kinases / Q000276:immunology / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods*; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D010510:Periodontal Diseases / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D050791:STAT Transcription Factors / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
D018836:Inflammation Mediators; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D050791:STAT Transcription Factors; D053612:Janus Kinases; D020928:Mitogen-Activated Protein Kinases