Regioselective synthesis and antimicrobial studies of ester linked 1,4-disubstituted 1,2,3-bistriazoles.
A series of 1,4-disubstituted 1,2,3-bistriazoles was synthesized via click chemistry by cycloaddition of various bisalkynes with benzyl/2-phenylethyl azide. Synthesized triazoles were characterized by IR, (1)H NMR, (13)C NMR and mass spectral techniques. All the compounds were evaluated for antibacterial/antifungal activities and found to possess moderate to good antimicrobial activities. Further the docking study for the most active compound against DNA Gyrase was also carried out.
Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, India.
Kashmiri
K
Lal
Ashwani
A
Kumar
M S
MS
Pavan
C P
CP
Kaushik
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001665:Binding Sites; D057930:Click Chemistry; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D027081:DNA Gyrase / Q000737:chemistry / Q000378:metabolism; D004952:Esters; D005658:Fungi / Q000187:drug effects; D008968:Molecular Conformation; D017434:Protein Structure, Tertiary; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
D000890:Anti-Infective Agents; D004952:Esters; D014230:Triazoles; D027081:DNA Gyrase