Analytical methods for immunogenetic population data.
In this chapter, we describe analyses commonly applied to immunogenetic population data, along with software tools that are currently available to perform those analyses. Where possible, we focus on tools that have been developed specifically for the analysis of highly polymorphic immunogenetic data. These analytical methods serve both as a means to examine the appropriateness of a dataset for testing a specific hypothesis, as well as a means of testing hypotheses. Rather than treat this chapter as a protocol for analyzing any population dataset, each researcher and analyst should first consider their data, the possible analyses, and any available tools in light of the hypothesis being tested. The extent to which the data and analyses are appropriate to each other should be determined before any analyses are performed.
Center for Genetics, Children's Hospital and Research Center Oakland, Oakland, CA, USA. sjmack@chori.org
Steven J
SJ
Mack
Pierre-Antoine
PA
Gourraud
Richard M
RM
Single
Glenys
G
Thomson
Jill A
JA
Hollenbach
D030541:Databases, Genetic; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D011110:Polymorphism, Genetic / Q000235:genetics; D012984:Software
D006680:HLA Antigens