Iron overload and toxicity: implications for anesthesiologists.
Conditions leading to iron overload range from rare hereditary disorders to more common medical conditions associated with chronic blood transfusions. Iron overload has deleterious effects on various vital organs (eg, liver, heart, and endocrine glands). Serum ferritin (in conjunction with transferrin saturation) is the most widely used test to evaluate iron burden and to screen for iron overload. The management plan should be adjusted to account for iron overload and potential consequences of liver, heart, and other organ involvement.
Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Englewood Hospital and Medical Center, Englewood, NJ 07631, USA. Aryeh.shander@ehmc.com
Aryeh
A
Shander
Ulrike
U
Berth
Joanne
J
Betta
Mazyar
M
Javidroozi
D000758:Anesthesia / Q000379:methods; D015415:Biomarkers / Q000097:blood; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000378:metabolism; D019190:Iron Overload / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014168:Transferrin / Q000378:metabolism
D015415:Biomarkers; D014168:Transferrin; D005293:Ferritins; D007501:Iron