Paraoxonase 1 (PON1) as a marker of short term death in breast cancer recurrence.
OBJECTIVE
To relate paraoxonase (PON1) activity to survival time and short term death in breast cancer recurrence.


METHODS
PON1 activity was measured by its rate of hydrolysis of two different substrates, paraoxon (PON) and phenylacetate (ARE) in 50 patients with recurrence of breast cancer. Results were compared between patients surviving more than one year after the analysis (22) and those who died within one year (28).


RESULTS
In a logistic regression analysis, ARE was negatively associated with early death (OR=0.10 [0.02-0.58], p=0.0109). PON did not reach significance (OR=0.43 [0.17-1.11], p=0.0826). In a multiple logistic regression analysis model, ARE was independently associated with early death (OR=0.12 [0.02-0.98], p=0.0476), besides interval time between diagnosis and recurrence (OR=0.54 [0.27-1.07], p=0.0781) and undernutrition (OR=3.95 [0.81-19.19], p=0.0883).


CONCLUSIONS
Paraoxonase is a potential marker of survival in patients with breast cancer recurrence.
Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Nantes, France.
Christine
C
Bobin-Dubigeon
Isabelle
I
Jaffré
Marie-Pierre
MP
Joalland
Jean-Marc
JM
Classe
Mario
M
Campone
Maxime
M
Hervé
Jean-Marie
JM
Bard
D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000097:blood* / Q000737:chemistry; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology* / Q000401:mortality; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000201:enzymology* / Q000401:mortality; D057075:Enzyme Assays; D005260:Female; D006801:Humans; D006868:Hydrolysis; D016015:Logistic Models; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000201:enzymology* / Q000401:mortality; D010261:Paraoxon / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D010648:Phenylacetates; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C025136:phenylacetic acid; D010261:Paraoxon