Diffuse amyloid deposition in thyroid gland: a cause for concern in familial Mediterranean fever.
Thyroid gland is among the many organs that could be infiltrated in systemic amyloidosis. However, diffuse infiltration of the thyroid gland secondary to systemic amyloidosis associated with Familial Mediterranean fever (FMF) is rare. Here, we present a 49-year-old woman diagnosed with FMF and systemic amyloidosis, who had a large goiter and multiple nodules that developed slowly through the years and was complicated by tracheal compression symptoms and a mild thyroid dysfunction. Multiple fine needle aspiration biopsies of the nodules and the thyroid parenchyma revealed amyloid deposits. We would like to point out that amyloidosis may have a significant impact on the thyroid gland and fine needle aspiration biopsy is a valuable tool for diagnosis.
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Özlem
Ö
Turhan İyidir
Mustafa
M
Altay
Ceyla
C
Konca Degertekin
Alev
A
Altınova
Ayhan
A
Karakoç
Göksun
G
Ayvaz
Metin
M
Arslan
Kürşad
K
Öneç
Turgay
T
Arınsoy
Nesibe
N
Cesur
Ipek Işık
II
Gönül
D010505:Familial Mediterranean Fever / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006042:Goiter / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000175:diagnosis*; D013961:Thyroid Gland / Q000473:pathology*