[The process of X inactivation in the mouse].
X chromosome inactivation (XCI) is an excellent model for studying how epigenetic marks are initiated during early embryogenesis. XCI is an essential process that takes place in females, leading to dosage compensation between males and females. In mouse, it occurs in two waves: the first one is paternally imprinted, during the preimplantation period and the second one occurs in a random fashion. We provide here an update of the main molecular steps and hypothesis underlining this complex process.
Faculté de médecine, université Paris Diderot, Paris, France. lucie.delaroche@bch.aphp.fr
Lucie
L
Delaroche
Pauline
P
Demailly
Katia
K
Ancelin
Catherine
C
Patrat
D000818:Animals; D002869:Chromosome Aberrations; D005260:Female; D018392:Genomic Imprinting / Q000235:genetics / Q000502:physiology; D008297:Male; D051379:Mice / Q000235:genetics* / Q000502:physiology; D008954:Models, Biological; D013045:Species Specificity; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology; D049951:X Chromosome Inactivation / Q000235:genetics / Q000502:physiology*