Foxp3: shades of tolerance.
In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Division of Immunology, the Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA. talal.chatila@childrens.harvard.edu
Talal A
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Chatila
Calvin B
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Williams