Design, synthesis, and spectroscopic properties of extended and fused pyrrolo-dC and pyrrolo-C analogs.
The syntheses of four fluorescent nucleoside analogs, related to pyrrolo-C (PyC) and pyrrolo-dC (PydC) through the conjugation or fusion of a thiophene moiety, are described. A thorough photophysical analysis of the nucleosides, in comparison to PyC, is reported.
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.
Mary S
MS
Noé
Andro C
AC
Ríos
Yitzhak
Y
Tor
D003562:Cytidine / Q000031:analogs & derivatives* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013057:Spectrum Analysis; D013876:Thiophenes / Q000737:chemistry
D005456:Fluorescent Dyes; D011758:Pyrroles; D013876:Thiophenes; C532171:pyrrolo-C; D003562:Cytidine