α-Glucosidase inhibitory constituents from Acanthopanax senticosus harm leaves.
A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant α-glucosidase inhibition activity.
Key Laboratory of Chinese Materia Medica-Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Zhi-Bin
ZB
Wang
Hai
H
Jiang
Yong-Gang
YG
Xia
Bing-You
BY
Yang
Hai-Xue
HX
Kuang
D028001:Eleutherococcus / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes