Genetic variability in swine leukocyte antigen class II and Toll-like receptors affects immune responses to vaccination for bacterial infections in pigs.
The genes encoding swine leukocyte antigen (SLA) and Toll-like receptor (TLR) are highly polymorphic in pig populations, and likely have influences on infection and the effects of vaccination. We explored the associations of different genotypes of SLA class II and of the genes TLR1, TLR4, TLR5, and TLR6 with antibody responses after vaccination against Erysipelothrix rhusiopathiae (ER) and Actinobacillus pleuropneumoniae (APP) serotypes 1, 2, and 5 in 191 Duroc pigs maintained under specific pathogen-free conditions. We demonstrated close relationships between SLA class II and ER antibody response and between TLR genes other than TLR4 and APP antibody responses. Pigs with specific haplotypes in SLA class II or TLR5 showed decreased antibody response to ER vaccination or increased responses to APP2 and APP5 vaccination, respectively. It might be possible to breed for responsiveness to vaccination and to implement new vaccine development strategies unaffected by genetic backgrounds of pigs.
Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305-8602, Japan.
H
H
Shinkai
A
A
Arakawa
M
M
Tanaka-Matsuda
H
H
Ide-Okumura
K
K
Terada
M
M
Chikyu
T
T
Kawarasaki
A
A
Ando
H
H
Uenishi
D000189:Actinobacillus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000276:immunology; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D002874:Chromosome Mapping; D004888:Erysipelothrix / Q000276:immunology; D004889:Erysipelothrix Infections / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D014644:Genetic Variation; D060005:Genotyping Techniques; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D051194:Toll-Like Receptor 1 / Q000235:genetics / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000276:immunology; D051198:Toll-Like Receptor 5 / Q000235:genetics / Q000276:immunology; D051216:Toll-Like Receptor 6 / Q000235:genetics / Q000276:immunology; D014611:Vaccination; D015164:Vaccines, Inactivated
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D000949:Histocompatibility Antigens Class II; D051194:Toll-Like Receptor 1; D051197:Toll-Like Receptor 4; D051198:Toll-Like Receptor 5; D051216:Toll-Like Receptor 6; D015164:Vaccines, Inactivated