XIAP: a potential determinant of ovarian follicular fate.
X-linked inhibitor of apoptosis protein (XIAP), a member of the inhibitor of apoptosis protein family, is involved in regulating a number of functions including receptor-mediated intracellular signalling and early development. Its role as an endogenous caspase inhibitor, however, is the most highly characterised. Consequently, this protein has been implicated as an anti-apoptotic factor in the ovary. In vitro and in vivo studies have begun dissecting the stimuli and signalling networks that lead to XIAP upregulation in granulosa cells. The objective of this review is to briefly summarise the current knowledge concerning XIAP and its interactions with different caspases. Furthermore, XIAP's emerging role in the mammalian ovary will be explored and comparison is made with its functions in the mammary gland. Finally, the idea that XIAP may act as a molecular signalling switch in granulosa cells following detachment from underlying layers to promote follicular atresia will be introduced.
Department of Anatomy, School of Medical Sciences, University of Otago, Dunedin 9016, New Zealand. hollian.phillipps@anatomy.otago.ac.nz
Hollian R
HR
Phillipps
Peter R
PR
Hurst
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D020169:Caspases / Q000378:metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008954:Models, Biological; D006080:Ovarian Follicle / Q000378:metabolism / Q000502:physiology*; D010053:Ovary / Q000254:growth & development / Q000378:metabolism / Q000502:physiology; D059748:Proteolysis; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D020169:Caspases