SLC30A8 (ZnT8) variations and  type 2 diabetes in the Chinese Han population.
In  recent genome-wide association studies, variants in the SLC30A8 gene have been  found to be associated with risk for type 2 diabetes. We examined a possible  association of tag SNPs spanning SLC30A8 and their haplotypes with type 2 diabetes  in the Chinese Han population. There were 1508 Chinese Han type 2 diabetes  patients and 1500 age- and gender-matched control subjects; all were genotyped  for three tagging SNPs (rs2466295, rs4876703, and rs11558471) of the human  SLC30A8 gene. The AA genotype of rs11558471 was found significantly more  frequently in type 2 diabetes patients than in controls (46 vs 24%). The  frequency of the A-C-A haplotype was significantly higher in type 2 diabetes  patients than in controls (0.331 vs 0.120). The frequency of the A-C-G  haplotype was significantly lower in type 2 diabetes patients than in controls  (0.160 vs 0.365). We conclude that type 2 diabetes is associated with  the AA genotype of rs11558471 in the human SLC30A8 gene. The A-C-A haplotype  appears to be a risk factor and the A-C-G haplotype may be a protective factor  against type 2 diabetes in Chinese Han.
Endocrinology Department of Southwest Hospital, Third Military Medical University, Chongqing, China.
J
J
Xu
J
J
Wang
B
B
Chen
D000328:Adult; D000368:Aged; D044466:Asian People; D027682:Cation Transport Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D000075703:Zinc Transporter 8
D027682:Cation Transport Proteins; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8