[Morphological defects of sperm flagellum implicated in human male infertility].
The assembly of sperm flagella involves specific components and processes that are still poorly defined. Several morphological defects of the different structures that compose the axoneme have been described and associated to human male infertility. These morphological defects can be classified in 15 main categories. Most of them have been associated to consanguinity and/or familial cases, suggesting their genetic origin. However, so far only few genes have been causally involved.
Inserm U933, université Pierre et Marie Curie, France.
Denise
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Escalier
Aminata
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Touré
D054468:Axoneme / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008928:Mitochondria / Q000473:pathology / Q000648:ultrastructure; D008954:Models, Biological; D013082:Sperm Tail / Q000473:pathology* / Q000502:physiology / Q000648:ultrastructure; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology; D013094:Spermatozoa / Q000002:abnormalities* / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure