Paraoxonase 1, atherosclerosis and arterial stiffness in renal patients.
Atherosclerosis is an important contributor to increased cardiovascular burden in populations with and without renal disease. Paraoxonases (PON) are a group of enzymes that hydrolyse organophosphates. Recent evidence indicates a protective role for PON in patients with coronary artery disease and atherosclerosis. Although data are limited, the low enzyme activity found in patients with chronic kidney disease and renal transplants has been linked to atherosclerosis and arterial stiffness. In this paper, we review the emerging role of PON1 in the pathophysiology of atherosclerosis and arterial stiffness in patients with chronic kidney disease.
Division of Nephrology, Ege University School of Medicine, 35100 Bornova, Izmir. ozkangungor@yahoo.com.tr
Ozkan
O
Gungor
Fatih
F
Kircelli
Huseyin
H
Toz
D043303:Aryldialkylphosphatase / Q000502:physiology*; D050197:Atherosclerosis / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000503:physiopathology; D059289:Vascular Stiffness
D043303:Aryldialkylphosphatase