Genetically elevated levels of circulating triglycerides and brachial-ankle pulse wave velocity in a Chinese population.
Elevated levels of circulating triglycerides and increased arterial stiffness are associated with cardiovascular disease. Numerous studies have reported an association between levels of circulating triglycerides and arterial stiffness. We used Mendelian randomization to test whether this association is causal. We investigated the association between circulating triglyceride levels, the apolipoprotein A-V (ApoA5) -1131T>C single nucleotide polymorphism and brachial-ankle pulse wave velocity (baPWV) by examining data from 4421 subjects aged 18-74 years who were recruited from the Chinese population. baPWV was significantly associated with the levels of circulating triglycerides after adjusting for age, sex, body mass index (BMI), systolic blood pressure, heart rate, waist-to-hip ratio, antihypertensive treatment and diabetes mellitus status. The -1131C allele was associated with a 5% (95% confidence interval 3-8%) increase in circulating triglycerides (adjusted for age, sex, BMI, waist-to-hip ratio, diabetes mellitus and antihypertensive treatment). Instrumental variable analysis showed that genetically elevated levels of circulating triglycerides were not associated with increased baPWV. These results do not support the hypothesis that levels of circulating triglycerides have a causal role in the development of arterial stiffness.
Department of Cardiology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
W-M
WM
Yao
H-F
HF
Zhang
Z-Y
ZY
Zhu
Y-L
YL
Zhou
N-X
NX
Liang
D-J
DJ
Xu
F
F
Zhou
Y-H
YH
Sheng
R
R
Yang
L
L
Gong
Z-J
ZJ
Yin
F-K
FK
Chen
K-J
KJ
Cao
X-L
XL
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D015854:Up-Regulation; D059289:Vascular Stiffness; D055815:Young Adult
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D015415:Biomarkers; D014280:Triglycerides