Cyclin d1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma.
BACKGROUND
Cyclin D1 regulates the G1 to S transition of cell cycle. Its deregulation or overexpression may lead to disturbance in the normal cell cycle control and tumour formation. Overexpression of cyclin D1 has been reported in various tumors of diverse histogenesis. This case control retrospective study was carried out to study the immunohistochemical reactivity and expression of cyclin D1 and its association with site, clinical staging, and histopathological differentiation of oral squamous cell carcinoma (OSCC).


METHODS
Forty formalin-fixed paraffin-embedded tissue blocks of biopsy specimens of oral squamous cell carcinoma were immunohistochemically evaluated for expression of cyclin D1.


RESULTS
Cyclin D1 expression was seen in 45% cases of OSCC. It did not correlate with site and clinical staging. Highest expression was seen in well-differentiated, followed by moderately differentiated, and poorly differentiated squamous cell carcinomas, with a statistically significant correlation.


CONCLUSIONS
Cyclin D1 expression significantly increases with increase in differentiation.
Department of Oral Pathology and Microbiology, Peoples Dental Academy, Bhanpur, Bhopal, 462037 MP, India. drswatisaawarn@gmail.com
Swati
S
Saawarn
Madhusudan
M
Astekar
Nisheeth
N
Saawarn
Nidhi
N
Dhakar
Shitalkumar
S
Gomateshwar Sagari
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D019938:Cyclin D1 / Q000378:metabolism*; D003937:Diagnosis, Differential; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology*; D013223:Statistics as Topic; D014018:Tissue Distribution
D014408:Biomarkers, Tumor; D019938:Cyclin D1