Scandium-44: benefits of a long-lived PET radionuclide available from the (44)Ti/(44)Sc generator system.
(44)Ti/(44)Sc radionuclide generators are of interest for molecular imaging. The 3.97 hours half-life of (44)Sc and its high positron branching of 94.27% may stimulate the application of (44)Sc-labeled PET radiopharmaceuticals. This review describes the current status of (44)Ti production, (44)Ti/(44)Sc radionuclide generator development, post-processing of generator eluates towards medical application, identification of ligands adequate to Sc(III) co-ordination chemistry, proof-of-principle labeling of (44)Sc-DOTA-octreotides, investigation of in vitro and in vivo parameters, and initial applications for molecular imaging - both in small animals and humans.
Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany. frank.roesch@uni-mainz.de
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D000327:Adsorption; D000818:Animals; D002411:Cation Exchange Resins; D002614:Chelating Agents / Q000138:chemical synthesis; D004355:Drug Stability; D006207:Half-Life; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging; D009532:Nickel; D009688:Nuclear Reactors; D049268:Positron-Emission Tomography; D011691:Puromycin / Q000138:chemical synthesis; D011868:Radioisotopes / Q000302:isolation & purification* / Q000493:pharmacokinetics; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D012538:Scandium / Q000302:isolation & purification* / Q000493:pharmacokinetics; D014025:Titanium / Q000302:isolation & purification*; D014183:Transplantation, Heterologous
D002411:Cation Exchange Resins; D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D011691:Puromycin; D009532:Nickel; D014025:Titanium; D012538:Scandium