Intraocular pressure fluctuation in patients with primary open-angle glaucoma combined with high myopia.
OBJECTIVE
To investigate whether patients with primary open-angle glaucoma combined with high myopia (POAG-HM) have short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise.


METHODS
Prospective Control Clinical Study. Eighty eyes of 80 high-tension Chinese POAG patients only on prostaglandin analog locally were categorized as per their degree of myopia (myopes 6 D or more, n=30 and between -0.76 and -5.99 D, n=29) or without myopia (n=21). Twenty-four-hour IOP fluctuations at resting conditions were observed in protocol 1, and IOP fluctuations after 10-minute exercise at 20% maximum Watt (Wmax) and followed by 5 minutes of exercise at 60% Wmax were observed in protocol 2.


RESULTS
Twenty-four-hour IOP fluctuations at resting conditions were not statistically significant among groups (P=0.58). After 10 minutes of moderate (20% Wmax) exercise, patients with POAG-HM had significant IOP decrease (3.50±2.76 mm Hg) over other subjects (analysis of covariance, age, as a covariate, was controlled, P=0.02). After 5 minutes of heavy (60% Wmax) exercise, patients with POAG-HM had significantly a greater postexercise IOP decrease (7.57±3.47 mm Hg) than other groups (P=0.00).


CONCLUSIONS
High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.
*Guang'anmen Hospital, China Academy of Chinese Medical Sciences †Beijing Tongren Eye Center, Beijing Tongren Hospital ∥Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine ‡Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing §Department of Anatomy, Histology and Embryology, Peking University School of Basic Medical Sciences ¶Beijing University of Chinese Medicine, Beijing, PR China.
Yingxin
Y
Yang
Zhen
Z
Li
Ningli
N
Wang
Lie
L
Wu
Yi
Y
Zhen
Tao
T
Wang
Caixia
C
Ren
Xiaoxia
X
Peng
Jie
J
Hao
Yanting
Y
Xia
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000150:complications / Q000503:physiopathology*; D011446:Prospective Studies; D014065:Tonometry, Ocular; D055815:Young Adult