An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America.
Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature.
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA. assumpcaot@niaid.nih.gov
Teresa C F
TC
Assumpção
Donald P
DP
Eaton
Van M
VM
Pham
Ivo M B
IM
Francischetti
Valéria
V
Aoki
Gunter
G
Hans-Filho
Evandro A
EA
Rivitti
Jesus G
JG
Valenzuela
Luis A
LA
Diaz
José M C
JM
Ribeiro
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000469:parasitology / Q000473:pathology; D001938:Brazil; D019295:Computational Biology; D015723:Gene Library; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D007303:Insect Vectors / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D010392:Pemphigus / Q000453:epidemiology* / Q000469:parasitology / Q000473:pathology; D012469:Salivary Glands / Q000378:metabolism; D017422:Sequence Analysis, DNA; D059467:Transcriptome; D014224:Triatoma / Q000145:classification / Q000235:genetics*
D019476:Insect Proteins