[Need for developing a new strategy in the follow-up of colorectal cancer patients; the micro RNAs (miRNAs), as potential new biomarkers of early detection].
In the mortality statistics of European countries colorectal cancers are known to assume the 2nd place after lung cancer. The mortality indices are particularly unfavourable in Hungary. Early detection is therefore of vital importance to the patient either the detection of the primary or recurrence after successful surgery is concerned. The latter is only feasible within a proper follow-up strategy. The present review focuses on follow-up due after surgical removal of the tumour with special emphasis on the efficacy of a new biomarker group (miRNAs) and their potential combination with the traditional markers. It is a model in the follow-up strategy that considers the results of risk assessment, as well. Since the methodology and strategy of follow-up are still controversial matters it is obvious that the development of a new follow-up strategy is imperative.
Országos Onkológiai Intézet, Budapest, Hungary. oroszeniko@oncol.hu
Enikõ
E
Orosz
István
I
Ember
Katalin
K
Gombos
László
L
Tóth
István
I
Vámosi Nagy
Adám
A
Tarpay
Akos
A
Pap
Szabolcs
S
Ottó
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D055088:Early Detection of Cancer / Q000379:methods*; D005060:Europe; D006301:Health Services Needs and Demand; D006801:Humans; D006814:Hungary; D035683:MicroRNAs / Q000032:analysis*; D011159:Population Surveillance / Q000379:methods*; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000235:genetics
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D035683:MicroRNAs; D002097:C-Reactive Protein