Genomes, populations and diseases: ethnic genomics and personalized medicine.
This review discusses the progress of ethnic genetics, the genetics of common diseases, and the concepts of personalized medicine. We show the relationship between the structure of genetic diversity in human populations and the varying frequencies of Mendelian and multifactor diseases. We also examine the population basis of pharmacogenetics and evaluate the effectiveness of pharmacotherapy, along with a review of new achievements and prospects in personalized genomics.
Research Institute for Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences.
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Stepanov