Accelerated long-term forgetting (ALF) and transient epileptic amnesia (TEA): two cases of epilepsy-related memory disorder.
Temporal lobe epilepsy (TLE) has long been associated with memory impairment. Recently, two specific forms of memory complaint in this population have been identified: accelerated long-term forgetting (ALF) and transient epileptic amnesia (TEA). This paper presents neuropsychological data (standard neuropsychological tests and experimental measures) on two patients who presented in the epilepsy clinic with seemingly similar subjective reports of profound memory difficulties. This paper illustrates the differences between TEA and ALF. Our focus was on measuring long-term forgetting utilizing a novel visual and verbal test protocol, with responses elicited via verbal prompts over the telephone at intervals up to 30 days. Whereas patient SK had neuropsychological test evidence of problems with learning plus ALF at short and long intervals without clinical evidence of TEA, patient EB had clinically convincing TEA without neuropsychological test evidence of ALF. In particular, SK showed accelerated forgetting while EB did not. This detailed case work develops our understanding of ALF measurement and demonstrates that ALF and TEA can be dissociated.
St. James's University Hospital, Leeds, UK. steven.kemp@leedsth.nhs.uk
Steven
S
Kemp
Nathan A
NA
Illman
Chris J A
CJ
Moulin
Alan D
AD
Baddeley
D000328:Adult; D000368:Aged; D000647:Amnesia / Q000150:complications* / Q000523:psychology; D004827:Epilepsy / Q000150:complications* / Q000523:psychology; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000150:complications* / Q000523:psychology; D009483:Neuropsychological Tests