Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis.
BACKGROUND
Microthrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN.


METHODS
Kidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with immunohistochemistry (IHC) for intravascular platelet aggregates (CD61), macrophagic infiltration (CD68), and activated complement deposition (C4d). Clinical data at the time of kidney biopsy and follow-up were analyzed with regard to pathologic IHC data.


RESULTS
Microthrombosis was present in 52% of the tissues. It was significantly more prevalent in patients with antiphospholipid antibodies (aPLs) (62% versus 42%). The presence of microthrombosis significantly correlated with higher macrophagic infiltration. Macrophagic infiltration but not microthrombosis was significantly correlated with C4d deposition. Only macrophagic infiltration showed a correlation with SLE and renal activity (proteinuria and active sediment), whereas neither the presence of CD61+ microthrombi nor the extent of C4d deposition correlated with LN severity or outcome.


CONCLUSIONS
Microthrombosis is associated with higher macrophagic infiltration in LN but does not seem to increase independently the severity of renal damage. Macrophagic infiltration was the best marker of SLE and renal activity in this LN series.
Instituto de Investigación Hospital 12 de Octubre (i+12), Avenida de Córdoba sn, 28041 Madrid, Spain.
Elena
E
Gonzalo
Oscar
O
Toldos
María P
MP
Martínez-Vidal
María C
MC
Ordoñez
Begoña
B
Santiago
Antonio
A
Fernández-Nebro
Estíbaliz
E
Loza
Isabel
I
García
Myriam
M
León
José L
JL
Pablos
María
M
Galindo
D000328:Adult; D000368:Aged; D003167:Complement Activation; D015935:Complement C4b; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology*; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D008181:Lupus Nephritis / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments; D015995:Prevalence; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D055815:Young Adult
D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d