[HPV-associated verrucous carcinoma of the perianal region--complete remission after surgical excision and postoperative monochemotherapy with methotrexat].
Verrucous carcinoma of the perianal area continues still to be rare finding, which in histopathological aspect is a highly differentiated form of squamous cell carcinoma. Many literature data show that it is quite possible that HPV viruses play probably a key role in the etiology of verrucous carcinoma. We present a case of 48 year-old female patient with verrucous carcinoma localized in the perianal area, treated initially under the diagnosis of perianal skin tags, while surgical removal of the lesion was found rare form of HPV associated verrucous carcinoma. A preventive mono-chemotherapy with methotrexate by scheme was started for an initial period of 3 months. Six months later, the provided monitoring has not shown clinical or apparative data on tumor recurrence. The article discusses key points of the diagnostic algorithm in patients with HPV associated lesions with anogenital localization and provides valuable recommendations for correct clinical behavior in these risk groups.
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Ananiev
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Tchernev
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D018289:Carcinoma, Verrucous / Q000188:drug therapy / Q000601:surgery / Q000628:therapy* / Q000821:virology*; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D010502:Perineum / Q000473:pathology / Q000601:surgery / Q000821:virology; D011184:Postoperative Period; D012074:Remission Induction; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy* / Q000821:virology*
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate