Use of BMPs and bisphosphonates in improving bone fracture healing.
In orthopaedics, focus is often placed on increasing bone formation by an anabolic drug like the recombinant human bone morphogenetic protein (rhBMP). However, premature or excessive bone resorption, due to stress-shielding, instability or infection/inflammation can lead to poor, delayed, or absent bone union. Anti-catabolic drugs such as bisphosphonates have therefore been explored to improve bone repair. This short review discusses the current literature underlying the anabolic-catabolic paradigm for bone repair with a focus on BMP and bisphosphonate combination approaches.
Department of Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. nicole.yu@sydney.edu.au
Nicole Y C
NY
Yu
Aaron
A
Schindeler
Magnus
M
Tagil
Andrew J
AJ
Ruys
David G
DG
Little
D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D004164:Diphosphonates / Q000494:pharmacology*; D017102:Fracture Healing; D006801:Humans
D019485:Bone Morphogenetic Proteins; D004164:Diphosphonates