[Research progress of the relationship between microglia and cerebral ischemia].
Microglia are the principal immune effectors in brain and participate in a series ofneurodegenerative diseases. The microglial shapes are highly plastic. The morphology is closely related with their activation status and biological functions. Cerebral ischemia could induce microglial activation, and microglial activation is subjected to precise regulation. Microglia could play either protective or neurotoxic roles in cerebral ischemia. Therefore, regulating the expression of receptors or protein molecules on microglia, inhibiting the excessive activation of microglia and production of pro-inflammatory factors, promoting the release of neuroprotective substances might be beneficial to the treatment of cerebral ischemia. The study about relationship between microglia and cerebral ischemia will shed a light on the treatment of cerebral ischemia. This paper is a review of microglial activation and regulation during cerebral ischemia as well as related therapeutic methods.
State Key laboratory of Natural Products and Functions, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wen-Jiao
WJ
Tai
Xuan
X
Ye
Xiu-Qi
XQ
Bao
Xiao-Liang
XL
Wang
Dan
D
Zhang
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology*; D058544:Class Ib Phosphatidylinositol 3-Kinase / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D017628:Microglia / Q000166:cytology / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D058486:Receptors, Purinergic P2X7 / Q000378:metabolism; D012038:Regeneration; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
D018696:Neuroprotective Agents; D058486:Receptors, Purinergic P2X7; D053221:TNF-Related Apoptosis-Inducing Ligand; D051193:Toll-Like Receptors; D019001:Nitric Oxide Synthase; D058544:Class Ib Phosphatidylinositol 3-Kinase; C546764:Pik3cg protein, mouse