KD4v: Comprehensible Knowledge Discovery System for Missense Variant.
A major challenge in the post-genomic era is a better understanding of how human genetic alterations involved in disease affect the gene products. The KD4v (Comprehensible Knowledge Discovery System for Missense Variant) server allows to characterize and predict the phenotypic effects (deleterious/neutral) of missense variants. The server provides a set of rules learned by Induction Logic Programming (ILP) on a set of missense variants described by conservation, physico-chemical, functional and 3D structure predicates. These rules are interpretable by non-expert humans and are used to accurately predict the deleterious/neutral status of an unknown mutation. The web server is available at http://decrypthon.igbmc.fr/kd4v.
Laboratoire de Bioinformatique et Génomique Intégratives, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France.
Tien-Dao
TD
Luu
Alin
A
Rusu
Vincent
V
Walter
Benjamin
B
Linard
Laetitia
L
Poidevin
Raymond
R
Ripp
Luc
L
Moulinier
Jean
J
Muller
Wolfgang
W
Raffelsberger
Nicolas
N
Wicker
Odile
O
Lecompte
Julie D
JD
Thompson
Olivier
O
Poch
Hoan
H
Nguyen
D004194:Disease / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D020407:Internet; D051188:Knowledge Bases; D020125:Mutation, Missense; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D012984:Software
D011506:Proteins