International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles.
The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.
EPL Northwest, Seattle, Washington 98119, USA. pmann@epl-inc.com
Peter C
PC
Mann
John
J
Vahle
Charlotte M
CM
Keenan
Julia F
JF
Baker
Alys E
AE
Bradley
Dawn G
DG
Goodman
Takanori
T
Harada
Ronald
R
Herbert
Wolfgang
W
Kaufmann
Rupert
R
Kellner
Thomas
T
Nolte
Susanne
S
Rittinghausen
Takuji
T
Tanaka
D000818:Animals; D038622:Internationality; D051379:Mice; D009369:Neoplasms; D010336:Pathology / Q000592:standards*; D051381:Rats; D009626:Terminology as Topic; D018675:Toxicity Tests; D014116:Toxicology / Q000592:standards*