Lamivudine treatment enabling right hepatectomy for hepatocellular carcinoma in decompensated cirrhosis.
A 69-year-old man was admitted to our hospital in October 2003, for further examination of two liver tumors. He was diagnosed with hepatocellular carcinoma (HCC) arising from decompensated hepatitis B virus (HBV)-related cirrhosis. Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC. His Child-Pugh score was 9 points at start of lamivudine treatment, improving to 5 points after 1 year. His indocyanine green at 15 min after injection test score was 48% before lamivudine treatment, improving to 22% after 2 years and to 5% after 4 years. Radiofrequency ablation controlled the HCC foci and maintained his liver function. In April 2009, abdominal computed tomography revealed a tumor thrombus in the right portal vein. Since his indocyanine green test results had improved to less than 10%, we performed a right hepatectomy, which was successful. To our knowledge, there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis. The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC.
First Department of Internal Medicine, Oita University, Oita 879-5593, Japan. hondak@oita-u.ac.jp
Koichi
K
Honda
Masataka
M
Seike
Shin-ichiro
S
Maehara
Koichiro
K
Tahara
Hideaki
H
Anai
Akira
A
Moriuchi
Toyokichi
T
Muro
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology / Q000601:surgery* / Q000821:virology; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000821:virology; D008113:Liver Neoplasms / Q000503:physiopathology / Q000601:surgery* / Q000821:virology; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine