Progressive multifocal leukoencephalopathy (PML) mimicking high-grade glioma on delayed F-18 FDG PET imaging.
The purpose of our study was to determine the increase in F-18 fluorodeoxyglucose (FDG) uptake in a patient with progressive multifocal leukoencephalopathy (PML) between early and late scan times using positron emission tomography (PET) imaging with F-18 FDG at conventional (60 minutes [min] after injection, PET(60)) and delayed (300 min after injection, PET(300)) intervals. PET(60) and PET(300) imaging was performed on a pathologically proven PML lesion. The PML lesion in the posterior fossa exhibited an increase in F-18 FDG uptake of 52% between early and late times, which was in the range of that in high-grade gliomas. Thus, dual-time-point PET with F-18 FDG may not be able to differentiate between infectious and malignant brain lesions.
Department of Nuclear Medicine, Polikliniek 7, Ghent University Hospital, De Pintelaan 185, Gent 9000, Belgium.
Koen
K
Mertens
Marjan
M
Acou
Caroline
C
Van den Broecke
Roel
R
Nuyts
Dirk
D
Van Roost
Eric
E
Achten
Ingeborg
I
Goethals
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001932:Brain Neoplasms / Q000503:physiopathology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000503:physiopathology*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
D019788:Fluorodeoxyglucose F18; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline