Polarity and lymphocyte fate determination.
Polarity within lymphocytes has been recognized to regulate a variety of processes, including migration, signaling, and the execution of effector function. It has been recently proposed, however, that this polarized behavior may also serve a different purpose in lymphocytes that have not yet encountered their foreign antigen-to coordinate asymmetric cell division. Asymmetric division is an evolutionarily conserved mechanism allowing a single cell to give rise to two distinct daughter cells from inception. In this review, recent findings in polarity and asymmetric division in lymphocytes are discussed.
Department of Medicine, University of California San Diego, La Jolla, CA, USA. changj@ucsd.edu
John T
JT
Chang
D000818:Animals; D060049:Asymmetric Cell Division; D019070:Cell Lineage; D016764:Cell Polarity; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000821:virology; D015398:Signal Transduction