Elevation of pulmonary artery pressure as a complication of nilotinib therapy for chronic myeloid leukemia.
We present the case of a 72-year-old male with chronic phase myeloid leukemia. Elevation of the pulmonary artery pressure due to nilotinib therapy was noted. This effect on pulmonary artery pressure was nilotinib dose dependent.
Department of Heart Valve Diseases, Institute of Cardiology, Warsaw, Poland. dzakrzewski@ikard.pl
Dariusz
D
Zakrzewski
Ilona
I
Seferynska
Krzysztof
K
Warzocha
Tomasz
T
Hryniewiecki
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D065627:Familial Primary Pulmonary Hypertension; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D010446:Peptide Fragments; D011743:Pyrimidines; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C498826:nilotinib