Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Han population.
Schizophrenia is one of highly heritable psychiatric disorders. Patients with early onset schizophrenia tend to have a greater genetic loading and may be an attractive subpopulation for genetics studies. A single nucleotide polymorphism (SNP) rs139887 in sex-determining region Y-box 10 (SOX10), a candidate gene for schizophrenia, was suggested to be associated with schizophrenia although inconsistent results had been reported. The aim of this study was to evaluate the association between SOX10 rs139887 polymorphism and schizophrenia using an early onset sample in the Chinese Han population. A total of 321 schizophrenic patients with onset before age 18 and 400 healthy controls were recruited for association study. In addition, two populations involved in three studies were selected for meta-analysis to determine the effect of rs139887 on schizophrenia. Our association study results showed that the allele and genotype frequencies were significantly different between schizophrenic patients and controls (P=0.013 and P=0.034, respectively). Interestingly, a significant association in allele and genotype frequencies were found in male patients (P=0.017 and P=0.045, respectively), but not female patients. Moreover, the C/C genotype had a significant association with an earlier age of onset in male schizophrenic patients (Kaplan-Meier log-rank test P=0.029), but not in female patients (Kaplan-Meier log-rank test P=0.876). The meta-analysis result showed the same C allele was significantly associated with schizophrenia (P=0.007). In conclusion, the SOX10 rs139887 polymorphism was related to the development of schizophrenia in a gender-specific manner, and may be a significant genetic marker for managing subgroups and etiological clues in schizophrenia.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, PR China.
Aihua
A
Yuan
Zhenghui
Z
Yi
Jinhua
J
Sun
Yasong
Y
Du
Tao
T
Yu
Chen
C
Zhang
Yi
Y
Liu
Ying
Y
Zhou
Dengtang
D
Liu
Huafang
H
Li
Yifeng
Y
Xu
Zaohuo
Z
Cheng
Weidong
W
Li
Shunying
S
Yu
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055757:SOXE Transcription Factors / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D012737:Sex Factors; D055815:Young Adult
C527923:SOX10 protein, human; D055757:SOXE Transcription Factors