Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants.
Acne vulgaris is a common dermatological condition characterized by hormonally-mediated sebum overproduction, follicular hyperkeratinization, and chronic inflammation of the pilosebaceous unit. Microbes, genetic susceptibilities, and various environmental factors have been linked to the pathogenesis of the condition. Over the last several years it has become apparent that patients with acne are under increased cutaneous and systemic oxidative stress. Moreover, the burden of oxidative stress may not be a mere consequence of acne; rather, the oxidative stress, lipid peroxidation in particular, may be an early event that helps to drive the acne process. Here, we explore the role of oxidative stress and review the preliminary research involving the administration of local and systemic antioxidants.
SUNY Downstate Medical Center, Department of Dermatolgy, Brooklyn, NY, USA. wpbowe@gmail.com
Whitney P
WP
Bowe
Nayan
N
Patel
Alan C
AC
Logan
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism*; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*
D000975:Antioxidants