Isoflurane hepatitis-induced liver failure: a case report.
A case of fulminant hepatic failure two days following an uneventful operation during isoflurane anesthesia is presented. Investigations included elevated bilirubin and serum transaminases in the absence of any other cause of hepatic dysfunction. The patient died on the fourth postoperative day. Subsequent postmortem examination showed centrilobular coagulative necrosis consistent with drug toxicity, with isoflurane as the most likely toxic agent.
Department of Surgery, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK. lashan_peiris@yahoo.co.uk
Lashan J
LJ
Peiris
Avi
A
Agrawal
John E
JE
Morris
Pradeep S
PS
Basnyat
D000368:Aged; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000009:adverse effects*; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000503:physiopathology; D009336:Necrosis
D018685:Anesthetics, Inhalation; D007530:Isoflurane