[Study on chemical constituents of Lycopodium alkaloids].
OBJECTIVE
To study the alkaloid chemical constituents of Lycopodium japonicum.


METHODS
Compounds were isolated and purified by such methods as silica gel column chromatography, RP-C18 reversed phase column chromatography, Sephadex LH-20 column chromatography and Waters semi-preparative liquid chromatogram, and their structures were identified based on physicochemical property and spectrum data.


RESULTS
Nine known alkaloid chemical constituents were isolated and identified, they were lycodoline (1), lucidioline (2), alpha-obscurine (3), lycopodine (4), lycoposerramine-L (5), lycoposerramine-M (6), 11alpha-O-acetyl-lycopodine (7), des-N-methyl-a-obscurine (8), clavolonine (9).


CONCLUSIONS
Compounds 4-9 were obtained from L. japonicum for the first time.
The Key Laboratory for Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China. Liuhuijie0217@gmail.com
Huijie
H
Liu
Ye
Y
Wang
D000470:Alkaloids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D032502:Lycopodium / Q000737:chemistry*
D000470:Alkaloids