[Non-coding small RNAs and spermatogenesis].
The continuous production of spermatozoa is a tightly regulated biological process, both at the transcriptional and post-transcriptional levels. Recently, different classes of small non-coding RNAs have emerged as important regulators of spermatogenesis. Available molecular and genetic data, although still fragmented, underscore their crucial role in regulating the fine tuning of gene expression required for testicular function. Here, we review the latest advances accomplished in this domain, spanning from the biogenesis of these small non-coding RNAs to their roles in male reproductive function.
Département de médecine génétique et développement, faculté de médecine, université de Genève, 1, rue Michel-Servet, 1211 Genève 4, Suisse.
Yannick
Y
Romero
Pierre
P
Calvel
Serge
S
Nef
D000818:Animals; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005854:Germ Cells / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008297:Male; D008954:Models, Biological; D058727:RNA, Small Untranslated / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012098:Reproduction / Q000235:genetics / Q000502:physiology; D043244:Ribonuclease III / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D013091:Spermatogenesis / Q000235:genetics* / Q000502:physiology
D058727:RNA, Small Untranslated; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases