Multiple endocrine neoplasia type 2A.
Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that expresses nonendocrine and endocrine tumors. Here, we describe a 42-year-old man with an initial presentation of low back pain and hypertension. Clinical assessments revealed pheochromocytoma, medullary thyroid carcinoma with bone metastasis, and parathyroid hyperplasia. MEN 2A was diagnosed, and a family history of pheochromocytoma was traced. Surgical resection of the pheochromocytoma of the adrenal gland resulted in a cure of the patient's hypertension. He received systemic chemotherapy with the "MAID" regimen (mesna, doxorubicin, ifosfamide, and dacarbazine) over three cycles of 3 weeks each, and showed a partial response.
Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Chiung-Tang
CT
Huang
Wen-Chi
WC
Yang
Sheng-Fung
SF
Lin
D000328:Adult; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis* / Q000532:radiotherapy