Robust optimization of alginate-Carbopol 940 bead formulations.
Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each response was evaluated like a noise variable, allowing the application of Taguchi techniques to obtain a response under the point of view of the signal to noise ratio. A L(18) Taguchi orthogonal array design was employed to investigate the effect of eight independent variables involved in the formulation of alginate-Carbopol beads. Responses evaluated were related to drug release profile from beads (t(50%) and AUC), swelling performance, encapsulation efficiency, shape and size parameters. Confirmation tests to verify the prediction model were carried out and the obtained results were very similar to those predicted in every profile. Results reveal that the robust optimization is a very useful approach that allows greater precision and accuracy to the desired value.
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, C/ Professor García González 2, 41012 Seville, Spain.
J M
JM
López-Cacho
Pedro L
PL
González-R
B
B
Talero
A M
AM
Rabasco
M L
ML
González-Rodríguez
D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry*; D000465:Algorithms; D002412:Cations; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008863:Microspheres; D015233:Models, Statistical; D011108:Polymers / Q000737:chemistry; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D013696:Temperature
D000180:Acrylic Resins; D000464:Alginates; D002412:Cations; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D011108:Polymers; C006903:carbopol 940; D020723:Glucuronic Acid