[Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats].
Intramuscular (i.m.) administration ofdiazepam in a dose of 10 mg/kg and adrenaline in a dose of 0.2 mg/kg prevents generalized clonic-tonic pentylenetetrazol (PTZ) seizures in 75-80 % of rats, but only in 35-40 % of rats it prevents local clonic PTZ seizures. In the above mentioned dose, diazepam causes a strong sedation, but adrenaline does not cause a sedative effects. The combined administration of diazepam and adrenaline in threshold independently ineffective doses prevents both clonic-tonic and clonic PTZ seizures in 80 % of rats without a sedation development. The basis for mechanism of potentiation of anticonvulsant action of diazepam is the stimulation of gastric mucosa afferents by adrenaline.
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D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage*; D004357:Drug Synergism; D004837:Epinephrine / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000187:drug effects; D006993:Hypnotics and Sedatives; D007273:Injections, Intramuscular; D008297:Male; D010433:Pentylenetetrazole / Q000008:administration & dosage; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D017833:Visceral Afferents / Q000187:drug effects
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D003975:Diazepam; D010433:Pentylenetetrazole; D004837:Epinephrine