Gulf War illnesses are autoimmune illnesses caused by reactive oxygen species which were caused by nerve agent prophylaxis.
Gulf War illnesses (GWI share many of the features of chronic fatigue syndrome (CFS) and both CFS and GWI may be the result of chronic immune system processes. The main suspected cause for GWI, the drug pyridostigmine bromide (PB), has been shown to cause neuronal damage from reactive oxygen species (ROS). ROS have been associated with IgM mediated autoimmune responses against ROS induced neoepitopes in depressed patients and this may also apply to CFS. It therefore follows that the drug used in the Gulf War caused ROS, the ROS modified native molecules, and that this trigged the autoimmune condition we refer to as Gulf War illnesses. Similar mechanisms may apply to other autoimmune illnesses.
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D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D018923:Persian Gulf Syndrome / Q000139:chemically induced* / Q000378:metabolism*; D011729:Pyridostigmine Bromide / Q000009:adverse effects* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism*
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D017382:Reactive Oxygen Species; D011729:Pyridostigmine Bromide