Eutectic salt catalyzed environmentally benign and highly efficient Biginelli reaction.
A simple deep eutectic solvent based on tin (II) chloride was used as a dual catalyst and environmentally benign reaction medium for an efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives, from aromatic and aliphatic aldehydes, 1,3-dicarbonyl compounds, and urea in good-to-excellent yields and short reaction time. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and tin chloride, is relatively inexpensive and recyclable, making it applicable for industrial applications.
Chemistry & Chemical Engineering Research Center of Iran, PO Box 14335-186, Tehran 1496813151, Iran. azizi@ccerci.ac.ir
Najmadin
N
Azizi
Sahar
S
Dezfuli
Mohmmad Mahmoodi
MM
Hahsemi
D000818:Animals; D001682:Biological Availability; D002384:Catalysis; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004355:Drug Stability; D011744:Pyrimidinones / Q000138:chemical synthesis; D011817:Rabbits; D012997:Solvents; D017971:Tin Compounds / Q000737:chemistry
D003692:Delayed-Action Preparations; D011744:Pyrimidinones; D012997:Solvents; D017971:Tin Compounds; C023599:stannous chloride; D002939:Ciprofloxacin