Ovarian tissue and follicle transplantation as an option for fertility preservation.
OBJECTIVE
To review and summarize data from the scientific literature on ovarian tissue and follicle transplantation as an option for fertility preservation.


METHODS
Review of pertinent literature.


METHODS
University hospital.


METHODS
Women having undergone ovarian tissue transplantation.


METHODS
None.


METHODS
Review of the literature.


RESULTS
Over the last decade, the field of ovarian transplantation and cryopreservation has significantly progressed, becoming applicable in humans. Indeed, fresh and frozen cortical ovarian tissue transplantations have been successfully reported worldwide, resulting in around 28 healthy babies. Although ovarian-tissue harvesting seems to be safe, the risk of reimplantation of cancer from ovarian cortical transplants cannot be estimated at this time. As a consequence, auto-transplantation of ovarian tissue in women having suffered from systemic hematological malignancies is not recommended. In these situations, reimplantation of isolated ovarian follicles might represent an interesting option in the future.


CONCLUSIONS
Although the clinical experience is limited, the robust results obtained open new perspectives for the management of premature ovarian failure resulting or not from gonadotoxic treatments.
Department of Obstetrics and Gynecology and Reproductive Medicine, Hôpital Antoine Béclère, Clamart, France. michael.grynberg@abc.aphp.fr
Michael
M
Grynberg
Marine
M
Poulain
Sarah
S
Sebag-Peyrelevade
Soizic
S
le Parco
Renato
R
Fanchin
Nelly
N
Frydman
D015925:Cryopreservation / Q000639:trends*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control* / Q000601:surgery*; D009369:Neoplasms / Q000628:therapy; D006080:Ovarian Follicle / Q000637:transplantation*; D010053:Ovary / Q000637:transplantation*; D014182:Transplantation, Autologous / Q000639:trends