Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy.
The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel-loaded nanoparticles with high loading efficiency and narrow-size distribution is successful. For non-invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti-tumor efficiency compared to the standard Taxol™, which is reflected in a significantly slower tumor growth compared to the NaCl control group.
Department of Pharmaceutics and Biopharmacy, Philipps-Universität Marburg, Marburg, Germany.
Thomas
T
Renette
Damiano
D
Librizzi
Thomas
T
Endres
Olivia
O
Merkel
Moritz
M
Beck-Broichsitter
Nadja
N
Bege
Holger
H
Petersen
Catherine
C
Curdy
Thomas
T
Kissel
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding; D004355:Drug Stability; D006801:Humans; D019344:Lactic Acid; D008546:Melanoma, Experimental; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D017239:Paclitaxel / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010316:Particle Size; D011095:Polyethylenes / Q000138:chemical synthesis*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D002250:Carbon Radioisotopes; D004337:Drug Carriers; D011095:Polyethylenes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C039212:polyethylene carbonate; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017239:Paclitaxel