Assessment of health risks with reference to oxidative stress and DNA damage in chromium exposed population.
Trivalent chromium [Cr(III)] is widely used in tanning industrial processes. The population living in tanning industrial area is continuously exposed to Cr(III) which appears to be associated with both acute and chronic health problems. Therefore, the aim of this study was to evaluate the health risk with special reference to oxidative stress parameters (malondialdehyde - MDA, glutathione - GSH, and superoxide dismutase - SOD) and DNA damage in 100 Cr-exposed and 100 unexposed populations. The total blood Cr level, SOD level, MDA level and DNA damage were significantly (p<0.05) higher and GSH level was significantly (p<0.05) lower in exposed group as compared to the unexposed group. The altered oxidative stress parameters and DNA damage were found to be slightly higher in female population of both groups. In simple and multiple correlation analyses (adjusted with potential confounders), blood Cr level showed negative significant correlation with GSH level and positive significant correlation with level of MDA, SOD and DNA damage in both groups. The overall prevalence of morbidity was found to be significantly (p<0.05) higher in the exposed group as compared to the unexposed group. In the exposed group, the prevalence of respiratory illness is highest, followed by diabetes, gastrointestinal tract problems and dermal problems respectively. Our results concluded that the Cr(III) exposed population is at high risk for health hazards and the female population is slightly more susceptible to Cr(III) exposure.
Molecular & Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow-226007, India.
Faizan Haider
FH
Khan
Khushboo
K
Ambreen
Ghizal
G
Fatima
Sudhir
S
Kumar
D000328:Adult; D002857:Chromium / Q000097:blood / Q000633:toxicity*; D020552:Comet Assay; D003430:Cross-Sectional Studies; D004249:DNA Damage; D003920:Diabetes Mellitus / Q000453:epidemiology; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology; D005978:Glutathione / Q000097:blood; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015995:Prevalence; D012140:Respiratory Tract Diseases / Q000453:epidemiology; D012871:Skin Diseases / Q000453:epidemiology; D013054:Spectrophotometry, Atomic; D013482:Superoxide Dismutase / Q000097:blood; D013633:Tanning; D055815:Young Adult
D004785:Environmental Pollutants; D002857:Chromium; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione