[Effect of selenium on resistance of hemoglobin to photooxidative processes].
On an example of a guinea pig it is shown that exogenous selenium (0.5 mg Na2SeO3 per 1 kg of the animal weight) during 2-hour exposition in the animal organism increases the resistance to the photo-induced oxidation of haemoglobin in erythrocyte lysates without additional stimulation of glutathione peroxidase mechanism of haemoglobin protection by exogenous selenium. It is shown that the saturation of haemoglobin fractions by selenium hampers the oxidative modification of haemoglobin. Using pregnancy of women as a natural model of selenium-deficiency condition, it has been shown that physiological debilitation of saturation erythrocytes with selenium, including haemoglobin fractions of lysates erythrocytes caused debilitation of resistance of haemoglobin to photooxidative destruction. Under these conditions not only activity of enzyme glutathione peroxidise in erythrocyte lysates, but also the peroxidase activity of haemoglobin (in the presence of glutathione) were decreased. It is more characteristic of erythrocyte lysates with a less content of selenium, i.e. for the erythrocytes of women on late terms of pregnancy that testifies to the presence of certain relation between haemoglobin saturation with selenium and its peroxidase activity (in the presence of glutathione).
T M
TM
Guseĭnov
F R
FR
Iakh''iaeva
R T
RT
Gulieva
D000328:Adult; D000818:Animals; D002457:Cell Extracts / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006168:Guinea Pigs; D006801:Humans; D008706:Methemoglobin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D012643:Selenium / Q000097:blood / Q000172:deficiency / Q000494:pharmacology*; D014466:Ultraviolet Rays
D002457:Cell Extracts; D008706:Methemoglobin; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium