The effects of retinoids on secondary wound healing: biometrical and histopathological study in rats.
OBJECTIVE
A wound healing is a complex process, and the role of retinoids in this process is debated and controversial. In this study, the effect of topical tretinoin and oral acitretin on wound healing process was investigated in full-thickness skin lesions on rat model.


METHODS
A circular full-thickness wound was created by 6 mm punch biopsy on the back side of 32 male rats. The rats were seperated into four equal. The first group was assigned as a control group and was observed with no treatment. The second group was administered dexpanthenol once a day over wound area. In the third group, 0.1% tretinoin cream was applied daily. In the fourth group, 2.5 mg/kg/day acitretin was given daily. Additionally, the biopsies were taken from wounds for the histopathologic examination.


RESULTS
The complete recovery time was remarkably longer in the tretionin group than the control group and the dexpantenol group (p < 0.05). The average complete recovery time was significantly longer in the acitretin group than the control and dexpanthenol groups whereas it was statistically shorter in the acitrein group than the tretionin group (p < 0.05).


CONCLUSIONS
Based on our findings, topical tretinoin and oral acitretin can delay secondary wound healing, epithelization and angiogenesis.
Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey. drserapgunes@yahoo.com
Serap
S
Gunes Bilgili
Omer
O
Calka
Necmettin
N
Akdeniz
Irfan
I
Bayram
Ahmet
A
Metin
D017255:Acitretin / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D062326:Re-Epithelialization / Q000187:drug effects; D012867:Skin / Q000293:injuries* / Q000473:pathology; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
D007641:Keratolytic Agents; D014212:Tretinoin; D017255:Acitretin