Totally implantable central venous access port infections in patients with digestive cancer: incidence and risk factors.
BACKGROUND
Central venous access port-related bloodstream infection (CVAP-BSI) is associated with morbidity and mortality in patients with cancer. This study examined the incidence rates and risk factors for CVAP-BSI in adult patients with digestive cancer.


METHODS
This prospective observational cohort study was performed from 2007 to 2011 in 2 oncology units of a university hospital. Incidence rate was expressed as number of CVAP-BSI per 1,000 catheter-days. A Cox regression model was used to identify risk factors for CVAP-BSI.


RESULTS
A total of 315 patients were included. CVAP-BSI occurred in 41 patients (13.0%). The overall incidence rate was 0.76/1,000 catheter-days. The rate was higher in patients with esophageal cancer (1.28. P = .05) and pancreatic cancer (1.24; P = .007). Risk factors independently associated with CVAP-BSI were World Health Organization performance status between 2 and 4, catheter utilization-days in the previous month, pancreatic cancer, and parenteral nutrition. Coagulase-negative Staphylococci and enterobacteria were the main microorganisms isolated.


CONCLUSIONS
In adult patients with digestive cancer, pancreatic cancer, cumulative catheter utilization-days, World Health Organization performance status, and parenteral nutrition were identified as independent risk factors for CVAP-BSI. Patients with any of these risk factors could be candidates for preventive strategies.
INSERM Unit 1060, INRA 1235, Unité de Nutrition Clinique Intensive, 103 Grande Rue de la Croix Rousse, University of Lyon, Lyon, France. abdoulayek2002@yahoo.fr
Abdoulaye
A
Touré
Philippe
P
Vanhems
Catherine
C
Lombard-Bohas
Philippe
P
Cassier
Denis
D
Péré-Vergé
Jean-Christophe
JC
Souquet
René
R
Ecochard
Cécile
C
Chambrier
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000382:microbiology; D015331:Cohort Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D062666:Vascular Access Devices / Q000382:microbiology*; D055815:Young Adult