CD8+ T cells: GITR matters.
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia, Via del Giochetto, 06100 Perugia, Italy.
Simona
S
Ronchetti
Giuseppe
G
Nocentini
Maria Grazia
MG
Petrillo
Carlo
C
Riccardi
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D053450:Glucocorticoid-Induced TNFR-Related Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000235:genetics / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology
D053450:Glucocorticoid-Induced TNFR-Related Protein