[Therapy for small airways disease: basic principles and therapeutic implications].
This paper describes the possibility of targeting the small airways. In addition to aiding in the therapy for chronic obstructive lung diseases this may prove to be invaluable in the development of treatment strategies for diseases of the bronchioli. Essential factors in peripheral lung deposition include extra-fine particles, a slow and controlled inspiratory flow and an endexspiratory breathhold of 5 - 10 sec (especially for steroids). Due to methodological difficulties, clinical data comparing steroids with larger or extra-fine particles are limited in the field of asthma therapy. However, research suggests a trend for reduced symptoms, positively affected biomarkers and decreased lung hyperinflation when steroids with extra-fine particles are used.
Fachkrankenhaus Kloster Grafschaft, Abteilung Pneumologie II, Schmallenberg. p.haidl@t-online.de
P
P
Haidl
C
C
Kroegel
M
M
Kohlhäufl
T
T
Voshaar
D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001982:Bronchial Diseases / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D006801:Humans
D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents