Short communication: broader T cell responses directed against human immunodeficiency virus type 1 in infected Chinese individuals through blood-borne transmission in comparison with mucosal transmission.
Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1), but less is known about the impact of transmission routes on immune defenses against HIV-1. Here, we report that subjects infected with HIV-1 through contaminated blood showed stronger HIV-specific T cell responses than those infected through mucosa, both in breadth (6.9±2.5 vs. 2.3±0.5, p=0.0293) and in magnitude [1270.0±544.9 vs. 409.5±121.3 SFU per million peripheral blood mononuclear cells (PBMCs), p=0.0223], by using a matrix of 404 overlapping peptides spanning all expressed HIV-1 proteins in an interferon (IFN)-γ enzyme-linked immunospot (ELISpot) assay. Our observation indicates that different mechanisms might be involved in the priming/generating of anti-HIV-specific T cell responses through different transmission routes.
Research Centre of Infection & Immunity, Beijing YouAn Hospital, Capital Medical University, Beijing, People's Republic of China.
Dongyan
D
Zhou
Xin
X
Zhang
Weihua
W
Li
Xiaoning
X
Xu
Nilu
N
Goonetilleke
Hongbing
H
Yang
Tao
T
Dong
Huiping
H
Yan
D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000209:etiology / Q000276:immunology* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications; D013601:T-Lymphocytes / Q000276:immunology*; D065227:Transfusion Reaction