Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.
The present study was aimed at investigating the behavioral and molecular effects of tianeptine. To this aim, Wistar rats were treated with tianeptine (5, 10 and 15 mg/kg) or imipramine (30 mg/kg) acutely and chronically. The results showed that both treatments reduced the immobility time. The BDNF levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, BDNF levels were increased in the prefrontal and hippocampus with tianeptine. Acute treatment decreased the citrate synthase activity in the prefrontal cortex with tianeptine, and increased it in the amygdala with imipramine; chronic treatment increased the citrate synthase in the hippocampus with tianeptine. The creatine kinase was increased in the prefrontal cortex with tianeptine and in the amygdala with imipramine after acute treatment; chronic treatment increased the creatine kinase activity in the hippocampus with imipramine and tianeptine. The complex I activity was decreased in the prefrontal cortex with imipramine and increased in the hippocampus with tianeptine. The other complexes were increased with imipramine and tianeptine at all doses, but were related to the treatment given and the brain area studied. Chronic treatment increased the malate dehydrogenase activity in the amygdala with tianeptine. Acute treatment decreased the succinate activity in the prefrontal cortex, hippocampus and amygdala with tianeptine; chronic treatment increased the succinate activity in the hippocampus with tianeptine at all doses. In conclusion, tianeptine exerted antidepressant-like behavior which can be attributed to its effects on pathways related to depression, such as BDNF and metabolism energy.
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil.
Franciela P
FP
Della
Helena M
HM
Abelaira
Gislaine Z
GZ
Réus
Karine F
KF
Ribeiro
Altamir R
AR
Antunes
Giselli
G
Scaini
Isabela C
IC
Jeremias
Lis Mairá M
LM
dos Santos
Gabriela C
GC
Jeremias
Emilio L
EL
Streck
João
J
Quevedo
D000704:Analysis of Variance; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002950:Citrate (si)-Synthase; D003402:Creatine Kinase; D004305:Dose-Response Relationship, Drug; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000523:psychology; D013841:Thiazepines / Q000494:pharmacology*
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D045222:Electron Transport Chain Complex Proteins; D013841:Thiazepines; C050504:tianeptine; D002950:Citrate (si)-Synthase; D003402:Creatine Kinase; D007099:Imipramine