CuI/DMPAO-catalyzed N-arylation of acyclic secondary amines.
DMPAO has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading.
School of Pharmacy, China Pharmaceutical University, Nanjing 21009, China.
Yu
Y
Zhang
Xinye
X
Yang
Qizheng
Q
Yao
Dawei
D
Ma
D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure
C576139:2-(2,6-dimethylphenylamino)-2-oxoacetic acid; D000588:Amines; D000814:Aniline Compounds; D007454:Iodides; D008024:Ligands; D003300:Copper; C073870:cuprous iodide