Cutaneous lupus after herpes zoster: isomorphic, isotopic, or both?
Koebner isomorphic response describes the phenomenon of histopathologically identical skin lesions of a preceding cutaneous disease appearing in sites of trauma. Wolf isotopic response describes the phenomenon of a new skin disease appearing in the site of an unrelated cutaneous disease. Neither of the phenomena has been reported in relation to systemic lupus erythematosus. This report describes a 17-year-old girl with systemic lupus erythematosus exhibiting particularly severe cutaneous involvement confined primarily to sun-exposed areas presenting with a dermatomal band of atrophic, scaling, erythematous papules, and plaques on her left shoulder extending down her left arm after herpes zoster eruption. The histopathologil result showed lupus erythematosus. This phenomenon is best considered as a Koebner isomorphic response, although Wolf isotopic response has some clinical relevance as well. Koebner isomorphic and Wolf isotopic responses are discussed as related to this case.
School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Nicole Y
NY
Lee
Alyssa S
AS
Daniel
David A
DA
Dasher
Dean S
DS
Morrell
D000293:Adolescent; D001706:Biopsy; D005260:Female; D006562:Herpes Zoster / Q000150:complications*; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000473:pathology / Q000821:virology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects