IgG-anti-IgA antibodies: an autoimmune finding in patients with psoriasis vulgaris.
OBJECTIVE
Psoriasis is thought to be an autoimmune disease caused by inappropriate activation of the cellular immune system. In this study, we aimed to search out IgG-anti-IgA antibody levels, serum immunoglobulins and antinuclear antibodies (ANA).


METHODS
The study enrolled 38 psoriasis vulgaris patients and 40 healthy controls.


RESULTS
Mean IgG-anti-IgA levels were significantly higher in psoriasis patients. The frequency of positive ANA testing was 21.1%; however, there was no correlation between IgG-anti-IgA antibody levels and ANA positivity. Only one patient had low IgA levels without high IgG-anti-IgA concentrations.


CONCLUSIONS
The data about high IgG-anti-IgA antibody levels are noteworthy for a new evidence of autoimmune mechanism.
Department of Pediatric Immunology, Ege University Medical School, Izmir, Turkey. elif.azarsiz@ege.edu.tr
E
E
Azarsiz
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I
Ertam
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N
Karaca
G
G
Aksu
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S
Alper
N
N
Kutukculer
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D015551:Autoimmunity / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D011565:Psoriasis / Q000276:immunology*
D000974:Antibodies, Antinuclear; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M