One core, two shells: bacterial and eukaryotic ribosomes.
Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Sergey
S
Melnikov
Adam
A
Ben-Shem
Nicolas
N
Garreau de Loubresse
Lasse
L
Jenner
Gulnara
G
Yusupova
Marat
M
Yusupov
D000818:Animals; D001419:Bacteria / Q000737:chemistry* / Q000166:cytology* / Q000378:metabolism; D005057:Eukaryotic Cells / Q000737:chemistry* / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D014176:Protein Biosynthesis; D012335:RNA, Ribosomal / Q000737:chemistry / Q000378:metabolism; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry* / Q000378:metabolism
D012335:RNA, Ribosomal; D012269:Ribosomal Proteins