Oxygenated lipids: a mode to WiPE out inflammation?
The immunologically silent clearance of apoptotic cells is crucial for maintaining self-tolerance. In this issue of Immunity, Uderhardt et al. (2012) reveal a mechanism by which lipid oxidation by tissue resident macrophages could inhibit the engulfment of apoptotic cells by inflammatory monocytes.
Department of Microbiology, Immunology and Cancer Biology, Carter Immunology Center, and Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA.
Amelia E
AE
Hochreiter-Hufford
Kodi S
KS
Ravichandran