A novel device to apply controlled flexion and extension to the rat knee following anterior cruciate ligament reconstruction.
We designed and validated a novel device for applying flexion-extension cycles to a rat knee in an in vivo model of anterior cruciate ligament reconstruction (ACL-R). Our device is intended to simulate rehabilitation motion and exercise post ACL-R to optimize physical rehabilitation treatments for the improved healing of tendon graft ligament reconstructions. The device was validated for repeatability of the knee kinematic motion by measuring the force versus angular rotation response from repeated trials using cadaver rats. The average maximum force required for rotating an ACL reconstructed rat knee through 100 degrees of flexion-extension was 0.4 N with 95% variability for all trials within ±0.1 N.
Hospital for Special Surgery, New York, NY 10021, USA. stasiakm@hss.edu
Mark E
ME
Stasiak
Dan
D
Wiznia
Saif
S
Alzoobaee
Michael C
MC
Ciccotti
Carl W
CW
Imhauser
Clifford
C
Voigt
Peter A
PA
Torzilli
Xiang-Hua
XH
Deng
Scott A
SA
Rodeo
D000818:Animals; D059549:Anterior Cruciate Ligament Reconstruction / Q000295:instrumentation*; D006614:Hindlimb / Q000502:physiology / Q000601:surgery*; D008297:Male; D055595:Mechanical Phenomena; D009068:Movement; D051381:Rats; D017207:Rats, Sprague-Dawley; D012046:Rehabilitation; D015203:Reproducibility of Results