A multicomponent synthetic strategy for two-carbon-tethered 1,3-oxathiole-indole pairs.
An efficient methodology for the multicomponent synthesis of new and highly functionalized heterocycles containing 1,3-oxathiole and indole units which are connected through an sp(2)-C(2) bridge has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C-S bond and a C-O bond in a one-pot operation. Features of this strategy include mild conditions, convenient one-pot operation, and high stereo- and regioselectivity.
School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P.R. China.
Jia-Yan
JY
Liu
Hao
H
Zhang
Bao-Ming
BM
Feng
Bo
B
Jiang
Shu-Liang
SL
Wang
Shu-Jiang
SJ
Tu
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D006573:Heterocyclic Compounds, 1-Ring; D007211:Indoles