[Activity of enzymatic detoxification systems in the mice liver under conditions of different retinoid provision].
The activity of cellular components of liver detoxification system was studied under the conditions of the absence of vitamin A stores. It is shown that a decrease of p-hydroxylase and N-demethylase activity of cytochrome P-450 simultaneously with a decrease of glutathione-S-transferase activity takes place in the liver microsomal fraction of vitamin A-deficient animals. At the same time the absence of retinoid stores in knock-out animals influences the decrease of only p-hydroxylase activity of cytochrome P-450 system. The increase in glutathione-S-transferase activity is observed in the liver postmicrosomal fraction in mice, kept on vitamin A-deficient diet, while its parametres in knock-out group animals were not statistically different compared to the control.
M M
MM
Marchenko
H P
HP
Kopyl'chuk
I O
IO
Shmarakov
I M
IM
Buchkovs'ka
D000217:Acyltransferases / Q000172:deficiency / Q000235:genetics; D000814:Aniline Compounds / Q000378:metabolism* / Q000633:toxicity; D000815:Aniline Hydroxylase / Q000378:metabolism*; D000818:Animals; D004032:Diet; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D018345:Mice, Knockout; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000378:metabolism*
D000814:Aniline Compounds; D014801:Vitamin A; D000815:Aniline Hydroxylase; D010089:Oxidoreductases, N-Demethylating; D000217:Acyltransferases; C056942:lecithin-retinol acyltransferase; D005982:Glutathione Transferase; D005978:Glutathione; C023650:aniline