Preparation of Ca-alginate biopolymer beads and investigation of their decorporation characteristics for 85Sr, 238U and 234Th by in vitro experiments.
The aim of this work was to investigate whether Ca-alginate biopolymer beads (CaABBs) can be used to reduce the bioavailability of radionuclides in the gastrointestinal tract of humans. The uptake of strontium, uranium and thorium from a simulated gastrointestinal system was studied by in vitro techniques using CaABBs. This agent was prepared from Na-alginate through cross-linking with divalent calcium ions according to the egg-box model. The effects of process variables such as pH of the gastrointestinal juice, incubation time and solid-to-solution ratio for the removal of radionuclides from the gastrointestinal juice were investigated. The results suggest that CaABBs are a potent material for reducing the bioavailability of radionuclides with a high uptake efficiency in the gastrointestinal tract.
Helmholtz-Zentrum München, German Research Center for Environmental Health, Institute of Radiation Protection, Neuherberg, Germany. cemgok@pau.edu.tr
Cem
C
Gok
Udo
U
Gerstmann
Vera
V
Höllriegl
Sule
S
Aytas
D000464:Alginates / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D005750:Gastric Juice / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010189:Pancreatic Juice / Q000737:chemistry; D013326:Strontium Radioisotopes / Q000494:pharmacology*; D013910:Thorium / Q000494:pharmacology*; D014501:Uranium / Q000494:pharmacology*
D000464:Alginates; D001704:Biopolymers; D003432:Cross-Linking Reagents; D013326:Strontium Radioisotopes; D014501:Uranium; D013910:Thorium