[The similarity and difference in the action of adriamycin and hydrogen peroxide on the myocardium].
The oxidative stress in cardiomyocytes is a component of cardiotoxic action of adriamycin. To distinguish the importance of this component we have compared initial effects of hydrogen peroxide and adriamycin on the contractile function and a tone of coronary vessels of the isolated rat heart. Adriamycin in concentration 3 mcM distinctly reduced developed pressure and heart rate, but raised coronary vessel tone. The concentration 1 mcM was inefficient at usual perfusion rate, but practically prevented rise in developed pressure and rates of its rise and fall at increased perfusion rate. Hydrogen peroxide also dose-dependently reduced developed pressure, but rates of its rise and fall were reduced to a lesser degree, while the heart rate slightly raised, and coronary vessel tone was reduced. Thus, the initial actions of hydrogen peroxide and adriamycin on the heart considerably differ. It suggests that the oxidative stress is not the main component of cardiotoxic action of adriamycin, at least, in its application in concentrations close to therapeutic ones.
V L
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Lakomkin
V I
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Kapel'ko
D000818:Animals; D003331:Coronary Vessels / Q000503:physiopathology; D004317:Doxorubicin / Q000008:administration & dosage*; D006321:Heart / Q000503:physiopathology*; D006861:Hydrogen Peroxide / Q000008:administration & dosage*; D008297:Male; D009206:Myocardium; D009924:Organ Culture Techniques; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017725:Ventricular Pressure / Q000187:drug effects*
D004317:Doxorubicin; D006861:Hydrogen Peroxide