Meta-analysis of the association between transforming growth factor-beta polymorphisms and complications of coronary heart disease.
OBJECTIVE
To investigate the association between common transforming growth factor beta (TGF-β) single nucleotide polymorphisms (SNP) and significant complications of coronary heart disease (CHD).


METHODS
We performed a meta-analysis of published case-control studies assessing the association of TGF-β SNPs with a range of CHD complications. A random effects model was used to calculate odds ratios and confidence intervals. Analyses were conducted for additive, dominant and recessive modes of inheritance.


RESULTS
Six studies involving 5535 cases and 2970 controls examining the association of common SNPs in TGF-β1 with CHD were identified. Applying a dominant model of inheritance, three TGF-β1 SNPs were significantly associated with CHD complications: The T alleles of rs1800469 (OR = 1.125, 95% CI 1.016-1.247, p = 0.031) and rs1800470 (OR = 1.146, 95% CI 1.026-1.279, p = 0.021); and the C allele of rs1800471 (OR = 1.207, 95% CI 1.037-1.406, p = 0.021).


CONCLUSIONS
This meta-analysis suggests that common genetic polymorphisms in TGF-β1 are associated with complications of CHD.
Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Townsville, Australia.
Dylan R
DR
Morris
Joseph V
JV
Moxon
Erik
E
Biros
Smriti M
SM
Krishna
Jonathan
J
Golledge
D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D016212:Transforming Growth Factor beta / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1