abd-A regulation by the iab-8 noncoding RNA.
The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism.
Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
Maheshwar
M
Gummalla
Robert K
RK
Maeda
Javier J
JJ
Castro Alvarez
Henrik
H
Gyurkovics
Swetha
S
Singari
Kevin A
KA
Edwards
François
F
Karch
Welcome
W
Bender
D000005:Abdomen / Q000254:growth & development; D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007246:Infertility / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics*; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D022661:RNA, Untranslated / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C062393:Abd-B proteins, Drosophila; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D035683:MicroRNAs; D009687:Nuclear Proteins; D022661:RNA, Untranslated; D014157:Transcription Factors; C526630:MIRN8 microRNA, Drosophila; C066591:abd-A protein, Drosophila