[CCR1 expression on immune cells in orbital tissue of patients with thyroid associated ophthalmopathy].
OBJECTIVE
To investigate the expression of CC chemokine receptor 1(CCR1) on the immune cells in orbital tissue of patients with thyroid associated ophthalmopathy(TAO).


METHODS
The tissue samples of orbital tissue were collected from 25 cases of TAO patient and 10 normal control subjects, and the expression of CCR1 in the immune cells was studied by SP immunohistochemistry. The correlation between CCR1 and clinical activity scores (GAS) was analyzed.


RESULTS
The expression of CCR1 on immune cells was positive, in orbital tissue of patients with TAO, and the positive rate was 84%, while it was negative or low positive in normal control subjects. The difference between them was significant (P < 0.05). In addition, the expression of CCR1 on the immune cells of orbital tissue with TAO had significant correlation with CAS (P < 0.05).


CONCLUSIONS
The expression of chemokine receptor CCR1 on the immune cells in orbital tissue of TAO patients is higher than that of normal subjects. CCR1 may play a role in the pathogenesis of TAO.
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Chun-Ling
CL
Liu
Bo
B
Guo
Xue-Jin
XJ
Zhang
Hong-Bin
HB
Lü
Li
L
Tang
Qing-Li
QL
Luo
D000328:Adult; D000368:Aged; D005260:Female; D049970:Graves Ophthalmopathy / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000378:metabolism*; D054389:Receptors, CCR1 / Q000378:metabolism*; D055815:Young Adult
C515300:CCR1 protein, human; D054389:Receptors, CCR1