Mechanisms of gravitational sensitivity of osteogenic precursor cells.
This report is a detailed review of the current data on the mechanic and gravitational sensitivity of osteoblasts and osteogenic precursor cells in vitro. It summarizes the numerous responses of cells with an osteoblastic phenotype and osteogenic precursor cells and especially their responses to the alteration of their mechanic or gravitational surroundings. The review also discusses the osteogenic cell's pathways of signal transduction and the mechanisms of gravitational sensitivity. It was shown that the earliest multipotent stromal precursor cells of an adult organism's bone marrow can sense changes of intensity in a gravitational or mechanic field in model conditions, which may play a certain role in the development of osteopenia in microgravity.
State Scientific Centre of Russian Federation - Institute for Biomedical Problems Russian Academy of Sciences.
L B
LB
Buravkova
P M
PM
Gershovich
J G
JG
Gershovich
A I
AI
Grigor'ev