Analysis of drug distribution from a simulated drug-eluting stent strut using an in vitro framework.
The mechanisms of delivery of anti-proliferative drug from a drug-eluting stent are defined by transport forces in the coating, the lumen, and the arterial wall. Dynamic asymmetries in the localized flow about stent struts have previously been shown to contribute to significant heterogeneity in the spatial distribution of drug in in silico three-compartmental models of stent based drug delivery. A novel bench-top experiment has been created to confirm this phenomena. The experiment simulates drug release from a single stent strut, and then allows visualization of drug uptake into both lumen and tissue domains using optical techniques. Results confirm the existence of inhomogeneous and asymmetric arterial drug distributions, with this distribution shown to be sensitive to the flow field surrounding the strut.
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia. cc.obrien123@gmail.com
Caroline C
CC
O'Brien
Charles H
CH
Finch
Tracie J
TJ
Barber
Penny
P
Martens
Anne
A
Simmons
D054855:Drug-Eluting Stents; D005456:Fluorescent Dyes / Q000493:pharmacokinetics*; D006801:Humans; D008955:Models, Cardiovascular; D010599:Pharmacokinetics
D005456:Fluorescent Dyes