Differences in microparticle release in patients with acute coronary syndrome and stable angina.
BACKGROUND
Microparticles (MP) are vesicles released from activated or apoptotic cells. Endothelial MP (EMP) are derived from injured endothelium, platelet MP (PMP) from activated platelets, and Annexin V positive MP (AMP) from apoptotic endothelial cells. The aim was to assess the release of MP and its association with inflammation and atherosclerotic burden.


RESULTS
AMP, EMP and PMP were measured on admission (Day 0) in 33 patients with stable angina (SA) and 43 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary interventions (PCI). In SA, peripheral artery disease (PAD) was assessed by ultrasound examination. In 30 of the 76 patients (20 ACS and 10 SA), MP, high-sensitivity-C-reactive protein (hs-CRP), and troponin T (TnT) levels were also assessed 24h (Day 1) and 48 h (Day 2) after PCI. AMP, EMP, and PMP were higher in ACS than in SA (all P<0.01). In the SA group, AMP, PMP, and EMP were similar in patients with or without PAD. In the ACS group, AMP increased until Day 2 (P=0.001), while EMP and PMP peaked on Day 1 (P<0.01) then decreased to baseline values. Day 2 AMP correlated with Day 2 TnT levels (r=0.43, P=0.01) while Day 1 EMP and PMP correlated with Day 1 hs-CRP (r=0.37, P=0.04 and r=0.33, P=0.05; respectively).


CONCLUSIONS
Higher MP levels were observed in ACS than in SA. Atherosclerotic burden did not affect MP levels in stable patients.
Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Roma, Italy. lmbiasucci@virgilio.it
Luigi Marzio
LM
Biasucci
Italo
I
Porto
Luca
L
Di Vito
Giovanni Luigi
GL
De Maria
Antonio Maria
AM
Leone
Giovanni
G
Tinelli
Alessandra
A
Tritarelli
Giuliana
G
Di Rocco
Francesco
F
Snider
Maurizio C
MC
Capogrossi
Filippo
F
Crea
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000628:therapy; D000368:Aged; D060050:Angina, Stable / Q000097:blood* / Q000628:therapy; D017304:Annexin A5 / Q000097:blood; D017209:Apoptosis; D050197:Atherosclerosis / Q000097:blood / Q000628:therapy; D001792:Blood Platelets / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D020107:Troponin T / Q000097:blood
D017304:Annexin A5; D020107:Troponin T; D002097:C-Reactive Protein