[The features of bulbo-spinal serotoninergic reaction in the young rats under the condition of acute somatic paiN].
Postnatal changes of background and stress-induced (by electric skin nociceptive irritation) concentrations of serotonin (S) and 5-oxyindolacetic acid (5-OIAA)in medulla oblongata and in spinal marrow was investigated using the male white rats (2-4, 17-18 and 30-35 days old). In the intact rats of these three groups the differences of S concentration in medulla oblongata were not revealed. S concentration in spinal marrow and 5-OIAA concentrations in both structures were changed in phase: decreased during vision-appearing period and increased during 1 month age. Rats of three groups showed the following reactions to the pain: 2-4 day rats - increase of spinal pool of S and 5-OIAA and decrease of 5-OIAA fraction in medulla oblongata; 17-18 day rats - hypo-S-shift in both structures, decrease 5-OIAA in spinal marrow and its increase in medulla oblongata; 30-35 day rats - pronounced reduction of both S and 5-OIAA at a bulbo-spinal level. Mechanisms of revealed postnatal changes of S metabolism in CNS and their role in age features of pain sensitivity formation in early ontogenesis were discussed.
A V
AV
Kapliev
V G
VG
Ovsiannikov
D059787:Acute Pain / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D051381:Rats; D059326:Serotonergic Neurons / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D012701:Serotonin