Protein engineering of penicillin acylase.
Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering.
Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University.
V I
VI
Tishkov
S S
SS
Savin
A S
AS
Yasnaya