Central precocious puberty: treatment with triptorelin 11.25 mg.
BACKGROUND
Few data are available on quarterly 11.25 mg GnRH analog treatment in central precocious puberty (CPP).


OBJECTIVE
To assess the efficacy of triptorelin 11.25 mg in children with CPP.


METHODS
17 patients (16 females) with CPP (7.9 ± 0.9 years) were treated with triptorelin 11.25 mg/90 days.


METHODS
Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pubertal signs were assessed at preinclusion and at inclusion visit, 3 months, 6 months, and 12 months of treatment. Results. At 3, 6, and 12 months, all patients had suppressed LH peak (<3 IU/L after GnRH stimulation), as well as prepubertal oestradiol levels. Mean LH peak values after GnRH test significantly decreased from 25.7 ± 16.5 IU/L at baseline to 0.9 ± 0.5 IU/L at M3 (P < 0.0001); they did not significantly changed at M6 and M12.


CONCLUSIONS
Triptorelin 11.25 mg/90 days efficiently suppressed the pituitary-gonadal axis in children with CPP from first administration.
Adolescent Medicine, I Pediatric Division, Department of Obstetrics, Gynecology and Pediatrics, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.
Elena
E
Chiocca
Eleonora
E
Dati
Giampiero I
GI
Baroncelli
Alessandra
A
Cassio
Malgorzata
M
Wasniewska
Fiorella
F
Galluzzi
Silvia
S
Einaudi
Marco
M
Cappa
Gianni
G
Russo
Silvano
S
Bertelloni
D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000097:blood; D006066:Gonads / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008186:Luteolytic Agents / Q000097:blood / Q000627:therapeutic use; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D011629:Puberty, Precocious / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000097:blood / Q000627:therapeutic use*
D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone