Structural diversity in native cyclodextrins/folic acid complexes--from [2]-rotaxane to exclusion compound.
The formation of different complexes of folic acid depending on the size of the host cyclodextrin resulting in either an exclusion compound (with the smallest α-cyclodextrin) or 2-rotaxane, where cyclodextrin is threaded over folic acid (with β- and γ-cyclodextrins), is presented. The formation is carried out in water which allows both possible application in pharmaceutical sciences and usage of environmentally friendly "green chemistry". The obtained compounds are thoroughly characterized using one and two dimensional NMR, mass spectrometry, differential scanning calorimetry and thermogravimetric analysis.
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PL-01-224 Warsaw, Poland. mceborska@ichf.edu.pl
Magdalena
M
Ceborska
Magdalena
M
Zimnicka
Mariusz
M
Pietrzak
Anna
A
Troć
Małgorzata
M
Koźbiał
Janusz
J
Lipkowski
D003505:Cyclodextrins / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D015394:Molecular Structure; D043862:Rotaxanes / Q000737:chemistry*
D003505:Cyclodextrins; D043862:Rotaxanes; D005492:Folic Acid