The effect of a multidisciplinary care clinic on the outcomes in pediatric chronic kidney disease.
BACKGROUND
Current best evidence-based practice for children with chronic kidney disease (CKD) attempts to achieve good clinical outcomes through careful management of comorbidities and is likely best achieved with a multidisciplinary care (MDC) CKD clinic.


METHODS
In this retrospective study of children with CKD in British Columbia, Canada, we analyzed clinical outcomes in a cohort of 73 CKD patients from 2003 under a standard care model and a second cohort of 125 CKD patients from 2009 under a MDC clinic model.


RESULTS
Patient demographics were similar, but there was a decrease in the percentage of patients with CKD stage 3-5 in 2009 (59 vs. 75 %; p = 0.002), although the absolute number increased. After adjustment for severity of CKD, hemoglobin was significantly higher (13.0 g/dl vs. 12.2 g/dl, p < 0.03), calcium was significantly higher (9.6 mg/dl vs. 9.1 mg/dl, p < 0.001), and albumin was significantly higher (4.4 g/dl vs. 3.8 g/dl, p < 0.001) in the 2009 MDC cohort. The rate of disease progression, assessed by annualized estimated glomerular filtration rate (eGFR) slope, improved from -4.0 ml/min/1.73 m(2) in the 2003 cohort to 0.5 ml/min/1.73 m(2) in the 2009 cohort (p < 0.01). Blood pressure control was better in 2009 although not statistically significant.


CONCLUSIONS
Multidisciplinary care improved the outcomes of children with CKD especially in anemia management, bone mineral metabolism, nutrition, and renal disease progression.
Department of Pediatrics, Division of Nephrology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada. mdsajarmeh@gmail.com
Salma
S
Ajarmeh
Lee
L
Er
Genevieve
G
Brin
Ognjenka
O
Djurdjev
Janis M
JM
Dionne
D000293:Adolescent; D000554:Ambulatory Care Facilities / Q000191:economics / Q000458:organization & administration* / Q000592:standards; D000740:Anemia / Q000453:epidemiology / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000628:therapy; D001955:British Columbia / Q000453:epidemiology; D016009:Chi-Square Distribution; D002648:Child; D015897:Comorbidity; D017046:Cost Savings; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006130:Growth Disorders / Q000453:epidemiology / Q000628:therapy; D017048:Health Care Costs; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000628:therapy; D033183:Interdisciplinary Communication; D007668:Kidney / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D009752:Nutritional Status; D009937:Organizational Objectives; D010348:Patient Care Team / Q000458:organization & administration* / Q000592:standards; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D059039:Standard of Care / Q000191:economics; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers