Regulation of endochondral ossification by transcription factors.
Endochondral ossification is very unique and complex biological event which is associated with skeletal development and tissue partnering. Genetic studies and gene-targeting approaches identified several transcription factors that play important roles in endochondral ossification. These transcription factors sequentially and harmoniously regulate each step of endochondral ossification, and consequently maintain the spatio-temporal control of the program. Importantly, these transcription factors form large protein complex to control chromatin remodeling, histone modification, transcription and splicing steps during endochondral ossification. It is also important to understand how these transcription factors regulate expression of their target genes. Biochemical and molecular cloning techniques largely contributed to identification of the components of the transcriptional complex and the target genes. Most recently, importance of endoplasmic reticulum (ER) stress in endochondral ossification has been reported. A transcription factor, BBF2H7, functions as an ER stress sensor in chondrocytes through regulation of appropriate secretion of chondrogenic matrices. We would like to discuss how the transcription factors regulate endochondral ossification.
Osaka University Graduate School of Dentistry, Molecular and Cellular Biochemistry, Suita, Osaka, Japan. rikonisi@dent.osaka-u.ac.jp
Riko
R
Nishimura
Kenji
K
Hata
Koichiro
K
Ono
Katsuhiko
K
Amano
Yoko
Y
Takigawa
Makoto
M
Wakabayashi
Rikako
R
Takashima
Toshiyuki
T
Yoneda
D000818:Animals; D001846:Bone Development / Q000235:genetics / Q000502:physiology; D002356:Cartilage / Q000254:growth & development / Q000378:metabolism; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism; D020219:Chondrogenesis / Q000235:genetics / Q000502:physiology; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D008954:Models, Biological; D010012:Osteogenesis / Q000235:genetics; D055758:SOX9 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D055758:SOX9 Transcription Factor; D014157:Transcription Factors