Percutaneous transhepatic biliary stenting vs. surgical bypass in advanced malignant biliary obstruction: cost- effectiveness analysis.
OBJECTIVE
This study aims to compare the clinical outcomes and costs between percutaneous transhepatic biliary stenting (PTBS) and surgical bypass.


METHODS
We randomly assigned 142 patients with unresectable malignant biliary obstruction between 2005 and 2010 to receive PTBS or surgical bypass as palliative treatment. PTBS was successfully performed in 70 patients who formed the PTBS group (failed in 7 patients). Sixty five patients underwent surgical bypass treatment. Additional gastrojejunostomy was performed in five patients. The effectiveness of biliary drainage, hospital stay, complications, cost, survival time and mortality were compared.


RESULTS
Patients in PTBS group had shorter hospital stay and lower initial and overall expense than the surgical group (p<0.05). There was no significant difference in effectiveness of biliary drainage (p=0.9307) or survival time between two groups (p=0.4826). Early complications of PTBS group was significantly lower than surgical group (3/75 vs. 11/65, p=0.0342). Late complication in PTBS group did not differ significantly from surgical group (9/70 vs. 6/65, p=0.6823). The survival curves in the two groups showed no significant difference (p=0.1032).


CONCLUSIONS
PTBD is a better palliative treatment than surgical bypass for unresectable malignant biliary obstruction for its high effectiveness of biliary drainage and acceptable expense and complication.
Department of Hepatobiliary Surgery and Molecular Surgery, People's Hospital Affiliated to Huzhou University Medical College, Huzhou, Zhejiang Province, China.
Li Qin
LQ
Yao
Cheng Wu
CW
Tang
Yin Yuan
YY
Zheng
Wen Ming
WM
Feng
San Xiong
SX
Huang
Ying
Y
Bao
D000328:Adult; D000368:Aged; D001662:Biliary Tract Surgical Procedures / Q000191:economics; D002779:Cholestasis / Q000628:therapy*; D003362:Cost-Benefit Analysis; D004322:Drainage; D005260:Female; D015390:Gastric Bypass / Q000191:economics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010166:Palliative Care; D015607:Stents