[Molecular mechanisms of peroxisome biogenesis in yeasts].
Peroxisomes contain oxidases generating hydrogen peroxide, and catalase degrading this toxic compound. Another characteristic function of each eukaryotic peroxisome, from yeast to man, is fatty acid beta-oxidation. However, in peroxisomes a variety of other metabolic pathways are located. In fungi, peroxisomes contain enzymes involved in catabolism of unusual carbon and nitrogen sources (methanol, purines, D-amino acids, pipecolynic acid, sarcosine, glycolate, spermidine etc) as well as biosynthesis of lysine in yeasts and penicillin in mycelial fungi. Impairment of peroxisomal structure and functions causes many human disorders. The similar defects have been identified in yeast mutants defective in peroxisomal biogenesis. Peroxisomal biogenesis is actively studied during last two decades using uni- and multicellular model systems. It was observed that many aspects of peroxisomal biogenesis and proteins involved in this process display striking similarity between all eukaryotes, from yeasts to humans. Yeast is a convenient model system for this kind of research. Current review summarizes data on molecular events of peroxisomal biogenesis, functions of peroxine proteins, import of peroxisomal matrix and membrane proteins and on mechanisms of peroxisomedivision and inheritance.
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Sibirnyĭ
D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000235:genetics; D001343:Autophagy / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D053858:Metabolic Networks and Pathways; D053402:PHEX Phosphate Regulating Neutral Endopeptidase / Q000145:classification / Q000235:genetics; D018901:Peroxisomal Disorders / Q000235:genetics*; D020675:Peroxisomes / Q000235:genetics* / Q000378:metabolism*; D021381:Protein Transport / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
D008565:Membrane Proteins; D029701:Saccharomyces cerevisiae Proteins; C085380:peroxisomal targeting sequence receptor; D053402:PHEX Phosphate Regulating Neutral Endopeptidase; C506231:PHEX protein, human; D000251:Adenosine Triphosphatases; D000074183:ATPases Associated with Diverse Cellular Activities; C511586:PEX1 protein, S cerevisiae