Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier.
Although hyaluronic acid (HA) has been conventionally utilized as a tissue adhesion barrier material, its rapid clearance in the body still remains as a big challenge in the clinical practice. In this study, we prepared a hydrogel of HA embedded in mildly crosslinked alginate (HA/mcALG hydrogel), which is injectable, easily covers injured tissues, and remains stably at the applied site during wound healing (by muco-adhesive HA embedded in the network structure of the mcALG hydrogel). The HA/mcALG hydrogel was highly effective for the prevention of peritoneal tissue adhesion compared to HA and mcALG hydrogels, and did not lead to any abnormal tissue responses during wound healing. The HA/mcALG hydrogel can be a good candidate as an injectable tissue adhesion barrier for clinical applications.
Department of Advanced Materials, Hannam University, 461-6 Jeonmin Dong, Yuseong Gu, Daejeon, 305-811, Republic of Korea.
Seung Yeon
SY
Na
Se Heang
SH
Oh
Kyu Sang
KS
Song
Jin Ho
JH
Lee
D000464:Alginates / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000494:pharmacology; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006097:Granulation Tissue / Q000187:drug effects / Q000254:growth & development; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D007267:Injections; D008954:Models, Biological; D010532:Peritoneal Diseases / Q000473:pathology / Q000517:prevention & control; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*
D000464:Alginates; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D006820:Hyaluronic Acid