Cyproterone synthesis, recognition and controlled release by molecularly imprinted nanoparticle.
In this study, we used novel synthetic conditions of precipitation polymerization to obtain nanosized cyproterone molecularly imprinted polymers for application in the design of new drug delivery systems. The scanning electron microscopy images and Brunauer-Emmett-Teller analysis showed that molecularly imprinted polymer (MIP) prepared by acetonitrile exhibited particles at the nanoscale with a high degree of monodispersity, specific surface area of 246 m(2) g(-1), and pore volume of 1.24 cm(3) g(-1). In addition, drug release, binding properties, and dynamic light scattering of molecularly imprinted polymers were studied. Selectivity of MIPs was evaluated by comparing several substances with similar molecular structures to that of cyproterone. Controlled release of cyproterone from nanoparticles was investigated through in vitro dissolution tests and by measuring the absorbance by HPLC-UV. The pH dissolution media employed in controlled release studies were 1.0 at 37 °C for 5 h and then at pH 6.8 using the pH change method. Results show that MIPs have a better ability to control the cyproterone release in a physiological medium compared to the non molecularly imprinted polymers (NMIPs).
Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.
Ebadullah
E
Asadi
Saman
S
Azodi-Deilami
Majid
M
Abdouss
Saeedeh
S
Khaghani
D001623:Betamethasone / Q000737:chemistry; D003534:Cyproterone / Q000138:chemical synthesis* / Q000737:chemistry; D003692:Delayed-Action Preparations; D005866:Gestonorone Caproate / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008027:Light; D054802:Molecular Imprinting / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D016062:Porosity; D012542:Scattering, Radiation; D012996:Solutions; D012997:Solvents; D013055:Spectrophotometry, Infrared
D003692:Delayed-Action Preparations; D011108:Polymers; D012996:Solutions; D012997:Solvents; D001623:Betamethasone; D003534:Cyproterone; D005866:Gestonorone Caproate