Preparation and antibiotic drug release of mineralized collagen coatings on titanium.
In this study, a mineralized collagen coating was electrolytically deposited onto titanium. The results showed that the mineralized collagen coatings with dense or porous morphology could be obtained. The mineral phase was mainly hydroxyapatite. In vitro evaluation showed the mineralized collagen coatings were stable in Kokubo's simulated body fluid, and displayed a good cytocompatibility in the cell multiplication test. The mineralized collagen coatings loaded with vancomycin hydrochloride showed an inhibitory effect on the growth of S.                 aureus. The present mineralized collagen coating demonstrates good suitability for surface modification of orthopedic metal implants.
Department of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.
Junjun
J
Tu
Mengfei
M
Yu
Yan
Y
Lu
Kui
K
Cheng
Wenjian
W
Weng
Jun
J
Lin
Huiming
H
Wang
Piyi
P
Du
Gaorong
G
Han
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002448:Cell Adhesion; D002460:Cell Line; D003094:Collagen / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004343:Drug Implants; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013211:Staphylococcus aureus / Q000187:drug effects; D014025:Titanium / Q000737:chemistry*; D014640:Vancomycin / Q000008:administration & dosage* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004343:Drug Implants; D014640:Vancomycin; D003094:Collagen; D014025:Titanium