Serum double monoclonal components and hematological malignancies: only a casual association? Review of 34 cases.
A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immunofixation. Of the 1214 patients with monoclonal gammopathies, 49 had a double MC but only 34 (2.8%) were included in our study. A double MC was associated with hematological malignancies in 20/34 cases. Based on our experience, a double MC is more often associated with other diseases, especially an oncohematological one.
Division of Hematology, Second University of Naples, Naples, Italy.
Salvatore
S
Guastafierro
Maria Giovanna
MG
Ferrara
Antonello
A
Sica
Rita Rosaria
RR
Parascandola
Sara
S
Santangelo
Umberto
U
Falcone
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D011379:Prognosis