Diet-induced swine model with obesity/leptin resistance for the study of metabolic syndrome and type 2 diabetes.
The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases.
Departamento de Reproducción Animal, INIA, 28040 Madrid, Spain.
L
L
Torres-Rovira
S
S
Astiz
A
A
Caro
C
C
Lopez-Bote
C
C
Ovilo
P
P
Pallares
M L
ML
Perez-Solana
R
R
Sanchez-Sanchez
A
A
Gonzalez-Bulnes
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D013045:Species Specificity; D013552:Swine / Q000145:classification / Q000378:metabolism*
D004041:Dietary Fats; D020738:Leptin