Surface modification with alginate-derived polymers for stable, protein-repellent, long-circulating gold nanoparticles.
Poly(ethylene) glycol is commonly used to stabilize gold nanoparticles (GNPs). In this study, we evaluated the ability of cysteine-functionalized alginate-derived polymers to both provide colloidal stability to GNPs and avoid recognition and sequestration by the body's defense system. These polymers contain multiple reactive chemical groups (hydroxyl and carboxyl groups) that could allow for ready functionalization with, for example, cell-targeting ligands and therapeutic drugs. We report here that alginate-coupled GNPs demonstrate enhanced stability in comparison with bare citrate-coated GNPs and a similar lack of interaction with proteins in vitro and long in vivo circulation as PEG-coated GNPs.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA.
Anu
A
Kodiyan
Eduardo A
EA
Silva
Jaeyun
J
Kim
Michael
M
Aizenberg
David J
DJ
Mooney
D000327:Adsorption; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000493:pharmacokinetics; D020723:Glucuronic Acid / Q000737:chemistry; D006046:Gold / Q000097:blood* / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011485:Protein Binding
D000464:Alginates; D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D006603:Hexuronic Acids; D011092:Polyethylene Glycols; D006046:Gold; D020723:Glucuronic Acid