A In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kB.
Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral infections. The activation of PRR by specific, highly conserved pathogen-associated molecular patterns (PAMPs) induces numerous immune reactions related both to innate and adaptive immunity. In addition to the well-studied Toll-like receptors, pathogens can be recognized by the receptors belonging to the other PRR families; including NOD-like receptors (NLR). Stimulation of members of NOD-like receptors (NOD1, 2) and Toll-like receptors results in the activation of the transcriptional factor NF-kB regulating gene expression in numerous molecules implicated in the development of proinflammatory reactions. As opposed to Toll-like receptors, the NF-kB-activating ability of NLRs has not been fully studied. In this work, we examine the ability of one member of the NLR family - NOD1 - to activate the main proinflammatory transcriptional factor NF-kB. We also compare the NF-kB-activating ability of NOD1 ligands of a different structure with TLR4,5 ligandsin vitroandin vivo.
Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences.
A I
AI
Tukhvatulin
D Y
DY
Logunov
I I
II
Gitlin
M M
MM
Shmarov
P V
PV
Kudan
Capital A Cyrillic А
CA
Adzhieva
A F
AF
Moroz
N N
NN
Kostyukova
L G
LG
Burdelya
B S
BS
Naroditsky
A L
AL
Gintsburg
A V
AV
Gudkov