[Effect of nitric oxide on 1 ml: peritoneal macrophages activity in normal pregnancy in white rats].
The activity of peritoneal macrophages, nitrotyrosine concentration and condition of free radical processes in normal pregnancy in white rats against the background of the introduction of donator (sodium nitrite) and inhibitor (Nw-nitro-L-arginine methyl ester) of nitric oxide was studied. During normal pregnancy in animals, nitrotyrosine concentration, the activity of free radical processes, and phagocytosis increase. With the introduction of nitric oxide donator, NO level increases and after the injection of antagonist of nitric oxide it is reduced. These changes are accompanied by increased lipid peroxidation and activation of phagocytic activity of macrophages.
A S
AS
Ivanova
O G
OG
Sitnikova
S B
SB
Nazarov
D000818:Animals; D005260:Female; D005609:Free Radicals / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage; D009569:Nitric Oxide / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000097:blood*; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D011247:Pregnancy; D051381:Rats; D012977:Sodium Nitrite / Q000008:administration & dosage; D014443:Tyrosine / Q000031:analogs & derivatives / Q000097:blood
D005609:Free Radicals; D009569:Nitric Oxide; C002744:3-nitrotyrosine; D014443:Tyrosine; D012977:Sodium Nitrite; D019331:NG-Nitroarginine Methyl Ester