Traceless chemical ligations from O-acyl serine sites.
Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Mirna
M
El Khatib
Mohamed
M
Elagawany
Farukh
F
Jabeen
Ekaterina
E
Todadze
Oleg
O
Bol'shakov
Alexander
A
Oliferenko
Levan
L
Khelashvili
Said A
SA
el-Feky
Abdullah
A
Asiri
Alan R
AR
Katritzky
D004151:Dipeptides / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D012694:Serine / Q000737:chemistry*
D004151:Dipeptides; D012694:Serine