Association between PPARγ2 Pro12Ala  polymorphism and myocardial infarction and obesity in  Han Chinese in Hohhot, China.
Activation of the peroxisome proliferator-activated  receptor g (PPARg) improves insulin sensitivity and inhibits atherosclerosis.  Whether PPARg2 Pro12Ala polymorphism affects myocardial infarction is not  clearly understood. We investigated a possible association of PPARg2 Pro12Ala  polymorphism with obesity and myocardial infarction in Han Chinese in Hohhot,  Inner Mongolia, China. We included 121 subjects with myocardial infarction and  137 healthy controls in our study. Triglycerides, total cholesterol,  low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol  were measured. The following information was recorded for each subject: age,  gender, body height, body weight, systolic blood pressure, and diastolic blood  pressure; the body mass index was calculated. PCR-RFLP was used to examine  Pro12Ala polymorphism. There were significant differences in clinical  characteristics between myocardial infarction patients and healthy controls,  except for diastolic blood pressure and triglycerides. The PP, PA/AA genotype  frequencies were 88.4 and 11.6% in myocardial infarction patients and 95.6 and  4.4% in controls, respectively (P = 0.031). Individuals with the A allele had a  significantly higher risk of myocardial infarction. The A allele was not an  independent risk factor for obesity. We conclude that PPARg2 Pro12Ala  polymorphisms are associated with increased risk for myocardial infarction in  Han Chinese in Hohhot.
Department of Cardiology of Affiliated Hospital, Inner Mongolia Medical College, Hohhot, China.
L P
LP
Wang
L R
LR
Zhao
H W
HW
Cui
M R
MR
Yan
L
L
Yang
X L
XL
Su
D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics*; D009765:Obesity / Q000150:complications / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
D047495:PPAR gamma