Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: a case report.
Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in her right arm, trunk and abdomen. Early recognition and diagnosis of these lesions as a due to cutaneous initial symptom of cutaneous disseminated aspergillosis, as well as prompt treatment with Liposomal amphotericin B + Itraconazole, secured successful recovery from the systemic infection. Skin lesions healed without any surgical treatment. The infant was discharged in good health. Long-term follow-up at three years of age revealed normality of all neurodevelopmental and cognitive parameters. To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis.
Neonatology and NICU, AO Regina Margherita-S Anna S Anna Hospital, Torino, Italy. paolomanzoni@hotmail.com
P
P
Manzoni
S
S
Rizzollo
C
C
Monetti
C
C
Carbonara
C
C
Priolo
E
E
Mastretta
L
L
Barberis
P
P
Galletto
P
P
Cigna
M L
ML
Leonessa
U
U
Sala
G
G
Gomirato
M
M
Mostert
M
M
Stronati
G
G
Ruffinazzi
C
C
Tzialla
E
E
Jacqz-Aigrain
F
F
Kaguelidou
D
D
Farina
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy*; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy*; D017964:Itraconazole / Q000627:therapeutic use; D016896:Treatment Outcome
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B