[Workplace testing of drugs of abuse and psychotropic drugs].
In France, workplace testing of drugs of abuse and psychotropic drugs is rarely performed; meanwhile it is a major public health problem. Furthermore, France is the European country that has been associated with the highest increase of the use of drugs of abuse, particularly cannabis. So workplace biological screening of drugs of abuse and of psychotropic drugs exposure is of major concern. New analytical techniques have been developed during the last years. The authors will consider analytical screening of drugs of abuse and particularly the comparison of analytical techniques applied to urine and saliva. The advantages and the disadvantages of these two matrices will be considered. Urinary and blood quantification will be reviewed, but also the interest of hair testing to explore chronic exposure. The research of psychotropic drugs in biological fluids is also a part of this paper. New analytical trends are promising and complete analysis of these substances will be soon routinely possible in blood using a single spot test.
Laboratoire de toxicologie et de pharmacocinétique, centre hospitalier universitaire, BP 577, Poitiers cedex, France.
P
P
Mura
E
E
Saussereau
B
B
Brunet
J-P
JP
Goullé
D019969:Amphetamine-Related Disorders / Q000175:diagnosis; D002186:Cannabinoids / Q000032:analysis; D002908:Chronic Disease; D019970:Cocaine-Related Disorders / Q000175:diagnosis; D013759:Dronabinol / Q000032:analysis; D005188:False Negative Reactions; D005189:False Positive Reactions; D005602:France; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis* / Q000652:urine; D009293:Opioid-Related Disorders / Q000175:diagnosis; D011619:Psychotropic Drugs / Q000032:analysis*; D015203:Reproducibility of Results; D012463:Saliva / Q000737:chemistry; D015813:Substance Abuse Detection / Q000379:methods*; D019966:Substance-Related Disorders / Q000175:diagnosis; D017132:Workplace
D002186:Cannabinoids; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D013759:Dronabinol