Polytherapy for migraine prophylaxis.
Migraine is a chronic neurological disorder with episodic manifestations, progressive in some individuals. Preventive treatment is recommended for patients with frequent or disabling attacks. A sizeable proportion of migraineurs in need of preventive treatment does not significantly benefit from monotherapy. This short review evaluates the role of pharmacological polytherapy in migraine prevention.
Casa di Cura S. Francesco, Viale Europa 21, 82037 Telese Terme, BN, Italy. gerardocasucci@tin.it
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Casucci
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Villani
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Cologno
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D'Onofrio
D002986:Clinical Trials as Topic / Q000379:methods; D004359:Drug Therapy, Combination / Q000379:methods*; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology* / Q000517:prevention & control; D009661:Nortriptyline / Q000008:administration & dosage; D000077236:Topiramate
D000077236:Topiramate; D005632:Fructose; D009661:Nortriptyline