Anticonvulsant-induced rickets and nephrocalcinosis.
Reported here is the case of a severely disabled young girl who developed Fanconi syndrome secondary to long-term valproic acid administration, ultimately leading to hypophosphatemic rickets. Although nephrocalcinosis is not a common feature in patients with proximal tubulopathy, the patient presented also with this condition, and the concomitant use of another anticonvulsant might have potentiated this condition. The purpose of this report is to increase awareness among healthcare providers of such rare but significant complications associated with anticonvulsants.
Pediatrics Department, McMaster University, Hamilton, Canada. kelau@mcmaster.ca
Keith K
KK
Lau
Koyelle
K
Papneja
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D005198:Fanconi Syndrome / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D009397:Nephrocalcinosis / Q000139:chemically induced* / Q000175:diagnosis; D012279:Rickets / Q000139:chemically induced* / Q000175:diagnosis; D012640:Seizures / Q000188:drug therapy; D000077236:Topiramate; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D014635:Valproic Acid