A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.
Early clinical investigations of candidate malaria vaccines and antimalarial medications increasingly employ an established model of controlled human malaria infection (CHMI). Study results are used to guide further clinical development of vaccines and antimalarial medications as CHMI results to date are generally predictive of efficacy in malaria-endemic areas. The urgency to rapidly develop an efficacious malaria vaccine has increased demand for efficacy studies that include CHMI and the need for comparability of study results among the different centres conducting CHMI. An initial meeting with the goal to optimize and standardise CHMI procedures was held in 2009 with follow-up meetings in March and June 2010 to harmonise methods used at different centres. The end result is a standardised document for the design and conduct of CHMI and a second document for the microscopy methods used to determine the patency endpoint. These documents will facilitate high accuracy and comparability of CHMI studies and will be revised commensurate with advances in the field.
Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, United States.
Matthew B
MB
Laurens
Christopher J
CJ
Duncan
Judith E
JE
Epstein
Adrian V
AV
Hill
Jack L
JL
Komisar
Kirsten E
KE
Lyke
Christian F
CF
Ockenhouse
Thomas L
TL
Richie
Meta
M
Roestenberg
Robert W
RW
Sauerwein
Michele D
MD
Spring
Angela K
AK
Talley
Vasee S
VS
Moorthy
D000818:Animals; D009033:Culicidae; D006801:Humans; D007299:Insect Bites and Stings; D008288:Malaria / Q000209:etiology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000276:immunology / Q000592:standards*
D017780:Malaria Vaccines