Asymmetric total synthesis of cladosporin and isocladosporin.
The first asymmetric total syntheses of cladosporin and isocladosporin were accomplished in 8 steps with 8% overall yield and 10 steps with 26% overall yield, respectively. The relative configuration of isocladosporin was determined via this total synthesis.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, PR China.
Huaiji
H
Zheng
Changgui
C
Zhao
Bowen
B
Fang
Peng
P
Jing
Juan
J
Yang
Xingang
X
Xie
Xuegong
X
She
D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D049934:Isocoumarins; C000488:cladosporin