Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells.
BACKGROUND
Aging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity.


METHODS
We aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT).


RESULTS
Elderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients.


CONCLUSIONS
This results can be translated into clinic as higher numbers of AHSCT candidates over age 60.
Department of Hematology, Ankara University School of Medicine, Ankara, Turkey. scivriz@hotmail.com
S
S
Civriz Bozdag
M
M
Bay
E
E
Ayyıldız
P
P
Topcuoglu
O
O
Ilhan
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous