[Antihypertensive efficacy of a low-dose combination of amlodipine and lisinopril in the treatment of arterial hypertension in postmenopausal women].
The present study had the objective to estimate the antihypertensive efficacy of a low-dose combination of amlodipine (5 mg) and lisinopril (equator, Gedeon Richter, Hungary; 10 mg) as well as its influence on the diastolic left ventricular function in the women presenting with arterial hypertension in the postmenopausal period A total of 60 postmenopausal women with grade II arterial hypertension available for the examination were allocated to two groups to be maintained on different therapeutic regimens. The study group was comprised of 40 patients treated with equator, and the control group included 20 patients receiving metoprolol and enalapril (12.5 mg and 10 mg respectively). In the beginning and the end of the study (total duration 6 months), all the patients underwent a comprehensive clinical and instrumental examination that included evaluation of their general clinical condition, 24-hour arterial blood pressure monitoring (BPM), electrocardiography (ECG), and doppleroechocardiography. It was shown that therapy with equator significantly decreased systolic and diastolic arterial pressure (SAP and DAP). Comparative analysis of the results of repeated doppleroechocardiography revealed the improvement of left ventricular diastolic function in the majority of the patients of group 1 (83%). It is concluded that systematic treatment with equator produces a stable hypotensive effect and normalizes circadian rhythms of arterial pressure. Moreover, adequate antihypertensive therapy improves diastolic left ventricular function. Treatment with equator is well tolerated by the patients and causes no serious adverse effects.
N N
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Gabieva
A B
AB
Bakhshaliev
D017311:Amlodipine / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017706:Lisinopril / Q000008:administration & dosage*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*
D000959:Antihypertensive Agents; D004338:Drug Combinations; D017311:Amlodipine; D017706:Lisinopril