Evaluation of a rapid point-of-care fecal antigen detection test for Entamoeba histolytica.
Amebiasis is a major cause of morbidity and mortality in the developing world. A reliable point-of-care test would help to improve diagnosis and early treatment. We evaluated a novel rapid fecal antigen detection test for E. histolytica (E. HISTOLYTICA QUIK CHEK; TechLab, Inc., Blacksburg, VA), in a cohort of children in Bangladesh where amebiasis is endemic. This point-of-care test had a sensitivity of 100% and a specificity of 100% when compared with enzyme-linked immunosorbent assay antigen detection.
Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1337, USA. psk9p@virginia.edu
Poonum S
PS
Korpe
Blake R
BR
Stott
Forida
F
Nazib
Mamun
M
Kabir
Rashidul
R
Haque
Joel F
JF
Herbein
William A
WA
Petri
D000562:Amebiasis / Q000175:diagnosis* / Q000453:epidemiology*; D000953:Antigens, Protozoan / Q000302:isolation & purification*; D001459:Bangladesh / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004748:Entamoeba histolytica / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D006801:Humans; D007223:Infant; D019095:Point-of-Care Systems; D012680:Sensitivity and Specificity; D013048:Specimen Handling
D000953:Antigens, Protozoan