Scale-up of isoniazid preventive therapy in PEPFAR-assisted clinical sites in South Africa.
We reviewed the implementation of isoniazid preventive therapy (IPT) in South Africa from January 2010 to March 2011. The South African National Department of Health distributed revised IPT guidelines in May 2010 to increase IPT use in eligible human immunodeficiency virus (HIV) infected  patients. We found a dramatic increase in the absolute numbers of patients reported to have been initiated on IPT (from 3309 in January-March 2010 to 49 130 in January-March 2011), representing an increase in the proportion (1.0-10.5%) of potentially eligible HIV-infected  patients started on IPT.
US Centers for Disease Control and Prevention South Africa, Pretoria, South Africa. BristowC@sa.cdc.gov
C C
CC
Bristow
E
E
Larson
A K
AK
Vilakazi-Nhlapo
M
M
Wilson
J D
JD
Klausner
D000995:Antitubercular Agents / Q000627:therapeutic use*; D003140:Communicable Disease Control / Q000379:methods*; D058872:Epidemics / Q000517:prevention & control*; D019983:Guideline Adherence; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D007391:International Cooperation; D007538:Isoniazid / Q000627:therapeutic use*; D009313:National Health Programs / Q000458:organization & administration; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D015397:Program Evaluation; D013019:South Africa; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control*
D000995:Antitubercular Agents; D007538:Isoniazid