Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats.
This paper shows a new finding about the decrease of relaxative response to loperamide in prostate of spontaneously hypertensive rats (SHR) as compare to normal rats (WKY). Authors demonstrated the reduction of ATP-sensitive potassium channels is responsible for this change using immunoblotting analysis and the decrease of action induced by diazoxide. This view is not mentioned before and is the first one reporting this result.
Department of Urology, College of Medicine, Wan-Fang Hospital, Taipei Medical University, Wang-Fang, Taipei 110, Taiwan.
Liang-Ming
LM
Lee
Chih-Cheng
CC
Lu
Hsien-Hui
HH
Chung
Juei-Tang
JT
Cheng
D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology; D003981:Diazoxide / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D054086:KATP Channels / Q000737:chemistry; D008139:Loperamide / Q000494:pharmacology*; D008297:Male; D015221:Potassium Channels / Q000737:chemistry; D024661:Potassium Channels, Inwardly Rectifying / Q000737:chemistry; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011957:Receptors, Opioid / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000737:chemistry; D013696:Temperature; D000099161:Kcnj11 Channel
D000255:Adenosine Triphosphate; D000930:Antidiarrheals; D003981:Diazoxide; D054086:KATP Channels; D008139:Loperamide; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D000099161:Kcnj11 Channel