Heterogeneous sensitivity of cerebral and muscle tissues to acute normobaric hyperoxia at rest.
The purpose was to investigate the effects of acute normobaric hyperoxia at rest on cerebral, respiratory and leg muscle oxygenation. Ten healthy men were studied twice in a single-blinded counterbalanced crossover study protocol. On one occasion they breathed air and on the other 100% normobaric O(2) for a 2-hour time period. Oxygenated (Δ[O(2)Hb]), deoxygenated (Δ[HHb]) and total (Δ[tHb]) hemoglobin in the cerebral frontal cortex, and in the intercostal and vastus lateralis muscles were simultaneously monitored with near-infrared spectroscopy. The hyperoxic stimulus promptly increased Δ[O(2)Hb] (~2 μM) and decreased Δ[HHb] (~3.6 μM) in the frontal cortex. These cerebral responses were directly and fully countered by resumption of normoxic air breathing. In contrast, Δ[HHb] significantly decreased due to the acute hyperoxic stimulus in both intercostal and vastus lateralis muscles. The temporal changes in muscle oxygenation were slower compared to those in the cerebral area; and they only partially recovered during the 15-min normoxic-recovery period. Acute supplementation of normobaric O(2) at rest influences cerebral, leg and respiratory muscle oxygenation of healthy individuals, but not in the same manner. Namely, the frontal cortex seems to be more sensitive to hyperoxia than are the skeletal muscle regions.
Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia. mkeram@phed.uoa.gr
Michail E
ME
Keramidas
Stylianos N
SN
Kounalakis
Nickos D
ND
Geladas
Ola
O
Eiken
Igor B
IB
Mekjavic
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001921:Brain; D002540:Cerebral Cortex / Q000378:metabolism*; D018592:Cross-Over Studies; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D018496:Hyperoxia / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D007366:Intercostal Muscles / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D052097:Quadriceps Muscle / Q000378:metabolism*; D012146:Rest; D016037:Single-Blind Method; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen