Inactivation of aerosolized Bacillus atrophaeus (BG) endospores and MS2 viruses by combustion of reactive materials.
Accidental release of biological agents from a bioweapon facility may contaminate large areas, possibly causing disastrous environmental consequences. To address this issue, novel halogen-containing reactive materials are being designed with the added capability to inactivate viable airborne microorganisms. This study determined the efficiency of combustion products of such materials to inactivate aerosolized bacteria and viruses. Spores of Bacillus atrophaeus and MS2 viruses dispersed in dry air were exposed for subsecond time intervals to hydrocarbon flames seeded with different reactive powders so that bioaerosol particles interacted with the combustion products in a controlled high-temperature environment. The experiments were designed to quantify differences in the biocidal effects of different reactive material powders including Al and Mg, a B•Ti nanocomposite, an 8Al•MoO(3) nanothermite, and a novel Al•I(2) nanocomposite. Compared to pure hydrocarbon flame, powder-seeded flame (with no iodine) produced about an order of magnitude greater inactivation of bacterial spores. The iodine-containing material increased the spore inactivation by additional 2 orders of magnitude. The aerosolized MS2 viruses (generally not as stress-resistant as spores) were fully inactivated when exposed to combustion of either the iodinated or noniodinated powders. Overall, the study suggests a great biocidal potential of combustion products generated by novel iodine-containing nanocomposite materials.
Center for Health-Related Aerosol Studies, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, United States. sergey.grinshpun@uc.edu
Sergey A
SA
Grinshpun
Atin
A
Adhikari
Michael
M
Yermakov
Tiina
T
Reponen
Edward
E
Dreizin
Mirko
M
Schoenitz
Vern
V
Hoffmann
Shasha
S
Zhang
D000391:Air Microbiology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects*; D006219:Halogens / Q000737:chemistry / Q000494:pharmacology*; D017909:Levivirus / Q000187:drug effects*; D013171:Spores, Bacterial / Q000187:drug effects*; D013242:Sterilization / Q000379:methods*
D000890:Anti-Infective Agents; D006219:Halogens