Genetic association analysis of ERBB4 polymorphisms with the risk of schizophrenia and SPEM abnormality in a Korean population.
The human receptor tyrosine-protein kinase erbB-4 (ERBB4) gene mediates neuregulin 1 (NRG1) signaling, and is involved in neuronal migration and differentiation. Despite the potential significance of ERBB4 in the development of schizophrenia, relatively few genetic studies for the association of ERBB4 with schizophrenia were performed in the populations including Ashkenazi Jews, Americans including Caucasians and African Americans, and Han Chinese. In this study, differences in ERBB4 variations were investigated to determine association with schizophrenia and smooth pursuit eye movement (SPEM) abnormality in a Korean population. Seven polymorphisms in ERBB4 gene were genotyped in 435 schizophrenia cases and 390 unrelated healthy controls. In order to investigate the relationship between ERBB4 and the risk of schizophrenia and SPEM abnormality, differences in SNP and haplotype distribution were analyzed using logistic and multiple regression analyses. However, we failed to replicate the associations reported by previous studies in other populations. Although statistically not significant, the tendency towards associations between ERBB4 polymorphisms and the risk of schizophrenia and SPEM abnormality in this study from a Korean population would be helpful for further genetic etiology studies in schizophrenia.
Laboratory of Genomic Diversity, Department of Life Science, Sogang University, Shinsu-dong, Mapo-gu, Seoul 121-742, Republic of Korea.
Joon Seol
JS
Bae
Charisse Flerida A
CF
Pasaje
Byung-Lae
BL
Park
Hyun Sub
HS
Cheong
Jeong-Hyun
JH
Kim
Jason Yongha
JY
Kim
Joong-Gon
JG
Shin
Chul Soo
CS
Park
Bong-Jo
BJ
Kim
Cheol-Soon
CS
Lee
Migyung
M
Lee
Woo Hyuk
WH
Choi
Tae-Min
TM
Shin
Jaewook
J
Hwang
Hyoung Doo
HD
Shin
Sung-Il
SI
Woo
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D066247:Receptor, ErbB-4; D056910:Republic of Korea; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*
C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4