High-throughput sequencing to decipher the genetic heterogeneity of deafness.
Identifying genes causing non-syndromic hearing loss has been challenging using traditional approaches. We describe the impact that high-throughput sequencing approaches are having in discovery of genes related to hearing loss and the implications for clinical diagnosis.
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Zippora
Z
Brownstein
Yoni
Y
Bhonker
Karen B
KB
Avraham
D003638:Deafness / Q000175:diagnosis / Q000235:genetics*; D018740:Genetic Heterogeneity; D034381:Hearing Loss / Q000235:genetics; D006801:Humans; D009154:Mutation; D017422:Sequence Analysis, DNA / Q000379:methods*