Hemodynamic responses and serum nitrite concentration during uncontrolled hemorrhagic shock in normotensive and hypertensive rats.
BACKGROUND
We evaluated the effect of hypertension on hemodynamic responses and serum nitrite concentrations in normotensive (NT) and deoxycorticosteron acetate (DOCA)-Salt hypertensive (HT) rats.


METHODS
Uncontrolled hemorrhagic shock was induced in NT and HT rats (n=7 each) by preliminary bleed of 25 ml/kg followed by a 75% tail amputation. The mean arterial pressure (MAP), heart rate and serum nitrite were measured pre-hemorrhage and during hemorrhage.


RESULTS
Changes in time-averaged MAP after hemorrhage were significantly greater in HT group than NT. After resuscitation, the HT rats failed to restore MAP to baseline level. Serum nitrite level in both groups was significantly increased during shock period. Survival rate of HT animals was lower than NT group, although it was not statistically significant.


CONCLUSIONS
Marked reduction of MAP and less improvement after resuscitation suggested the less adaptation of cardiovascular system in HT animals which may interfere with management of these subjects during uncontrolled hemorrhagic shock.
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. khazaei@med.mui.ac.ir
Majid
M
Khazaei
Babak
B
Barmaki
Ali
A
Nasimi
D000818:Animals; D062186:Arterial Pressure; D006339:Heart Rate; D006973:Hypertension / Q000150:complications*; D008297:Male; D009573:Nitrites / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D012965:Sodium Chloride / Q000494:pharmacology
D009573:Nitrites; D012965:Sodium Chloride