Exposure assessment of boron in Bandırma boric acid production plant.
Boric acid and sodium borates have been considered as being "toxic to reproduction and development", following results of animal studies with high doses. Experimentally, a NOAEL of 17.5mg B/kg-bw/day (corresponds to ∼2020 ng boron/g blood) has been identified for the (male) reproductive effects of boron in a multigenerational study of rats, and a NOAEL for the developmental effects in rats was identified at 9.6 mg B/kg-bw/day (corresponds to 1270 ng boron/g blood). These values are being taken as the basis of current EU safety assessments. The present study was conducted to assess the boron exposure under extreme exposure conditions in a boric acid production plant located in Bandırma, Turkey. The mean blood boron concentrations of low and high exposure groups were 72.94 ± 15.43 (48.46-99.91) and 223.89 ± 60.49 (152.82-454.02)ng/g respectively. The mean blood boron concentration of the high exposure group is still ≈ 6 times lower than the highest no effect level of boron in blood with regard to the developmental effects in rats and ≈ 9 times lower than the highest no effect level of boron in blood with regard to the reprotoxic effects in male rats. In this context, boric acid and sodium borates should not be considered as toxic to reproduction for humans in daily life.
Ankara University, Faculty of Pharmacy, Department of Toxicology, 06100 Tandoğan, Ankara, Turkey. duydu@pharmacy.ankara.edu.tr
Yalçin
Y
Duydu
Nurşen
N
Başaran
Hermann M
HM
Bolt
D000818:Animals; D001895:Boron / Q000032:analysis* / Q000097:blood / Q000652:urine; D004785:Environmental Pollutants / Q000009:adverse effects / Q000032:analysis*; D006801:Humans; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D016273:Occupational Exposure; D051381:Rats
D004785:Environmental Pollutants; D001895:Boron