Superfamily 2 helicases.
Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in DNA metabolism.  This review focuses on the basic mechanistic, structural and biological properties of each of the families of helicases within superfamily 2.  There are ten separate families of helicases within superfamily 2, each playing specific roles in nucleic acid metabolism.  The mechanisms of action are diverse, as well as the effect on the nucleic acid.  Some families translocate on single-stranded nucleic acid and unwind duplexes, some unwind double-stranded nucleic acids without translocation, and some translocate on double-stranded or single-stranded nucleic acids without unwinding.
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Alicia K
AK
Byrd
Kevin D
KD
Raney
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000145:classification / Q000235:genetics / Q000378:metabolism; D004265:DNA Helicases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D004795:Enzyme Stability; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D020365:RNA Helicases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D012328:RNA Viruses / Q000201:enzymology / Q000235:genetics; D053484:RecQ Helicases / Q000145:classification / Q000235:genetics / Q000378:metabolism
D004265:DNA Helicases; D053484:RecQ Helicases; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases