Increased levels of YKL-40 and interleukin 6 in patients with chronic pancreatitis and secondary diabetes.
OBJECTIVE
Circulating levels of YKL-40 and interleukin 6 (IL-6) are elevated in patients with type 2 diabetes. We aimed to evaluate YKL-40 levels in patients with chronic pancreatitis (CP) with and without secondary diabetes mellitus (DM) to investigate whether elevated plasma YKL-40 could play a primary role in the pathogenesis of type 2 diabetes or rather represent a consequence of the diabetic state.


METHODS
Plasma levels of YKL-40 and IL-6 were measured during an oral glucose tolerance test in 8 patients with CP and secondary DM, 8 patients with CP and normal glucose tolerance (NGT), and 8 healthy control subjects (CTRLs).


RESULTS
Plasma YKL-40 and IL-6 were significantly higher in patients with CP and secondary DM (YKL-40, mean [95% confidence interval], 113 [60-215 ng/mL]; IL-6, 4.6 [2.3-9.1 pg/mL]) compared to patients with CP and NGT (YKL-40, 42 [28-63 ng/mL]; IL-6, 1.4 [0.8-2.4 pg/mL]) and healthy control subjects (YKL-40, 46 [31-69 ng/mL]; IL-6, 1.4 [0.8-2.4 pg/mL]).


CONCLUSIONS
Patients with CP and secondary DM have elevated levels of YKL-40 and IL-6 compared to CP patients with NGT and healthy subjects, suggesting that YKL-40 is not a primary mediator of DM but a consequence of the diabetic state.
Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark.
Morten
M
Hansen
Anders Rinnov
AR
Nielsen
Tina
T
Vilsbøll
Asger
A
Lund
Thure
T
Krarup
Filip Krag
FK
Knop
Henrik
H
Vestergaard
D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D000071451:Chitinase-3-Like Protein 1; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000150:complications
D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; C508600:IL6 protein, human; D015850:Interleukin-6; D037102:Lectins