Antinociceptive activity of ethanol extract from Duguetia chrysocarpa Maas (Annonaceae).
The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg. The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms. The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus.
Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil. jackson.guedes@univasf.edu.br
Jackson Roberto Guedes da Silva
JR
Almeida
Edigênia Cavalcante da Cruz
EC
Araújo
Luciano Augusto de Araújo
LA
Ribeiro
Julianeli Tolentino
JT
de Lima
Xirley Pereira
XP
Nunes
Ana Sílvia Suassuna Carneiro
AS
Lúcio
Maria de Fátima
Mde F
Agra
José Maria
JM
Barbosa Filho
D000143:Acids / Q000737:chemistry; D000470:Alkaloids / Q000737:chemistry; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000880:Anthraquinones; D019817:Benzoic Acid / Q000737:chemistry; D002621:Chemistry / Q000379:methods; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010146:Pain; D010147:Pain Measurement / Q000379:methods; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology; D058009:Stramenopiles / Q000378:metabolism*; D013696:Temperature
D000143:Acids; D000470:Alkaloids; D000700:Analgesics; D000880:Anthraquinones; D010936:Plant Extracts; D000431:Ethanol; D019817:Benzoic Acid; C027113:chrysophanic acid