Short and long-term effects of Baccharis articulata on glucose homeostasis.
In this study, the in vivo effect of the crude extract and n-butanol and aqueous residual fractions of Baccharis articulata (Lam.) Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as in vitro action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the n-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the n-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. In vitro incubation with the crude extract and n-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs). Thus, the results demonstrated that B. articulata exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for B. articulata indicate potential anti-diabetic properties.
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Cx. Postal 5069, CEP 88040-970, Florianópolis, SC, Brazil.
Virginia D
VD
Kappel
Danielle F
DF
Pereira
Luisa H
LH
Cazarolli
Samantha M
SM
Guesser
Carlos H Blum
CH
da Silva
Eloir P
EP
Schenkel
Flávio H
FH
Reginatto
Fátima R M B
FR
Silva
D020001:1-Butanol / Q000737:chemistry; D000818:Animals; D031175:Baccharis / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D017127:Glycation End Products, Advanced; D006003:Glycogen / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D006031:Glycosylation / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin; D013995:Time; D013997:Time Factors; D000093423:Glycated Serum Albumin
D001786:Blood Glucose; D005419:Flavonoids; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007328:Insulin; D010636:Phenols; D010936:Plant Extracts; D012709:Serum Albumin; D020001:1-Butanol; D006003:Glycogen; D005947:Glucose; D000093423:Glycated Serum Albumin