[Hypothyroidism prevalence and its relationship to high levels of thyroid peroxidase antibodies and urinary iodine in a population aged 35 and over from Armenia, 2009-2010].
OBJECTIVE
Determining the prevalence of hypothyroidism and its interrelationship with peroxidase antibodies and high urinary iodine levels as a means for devising a set of recommendations for health authorities regarding the consumption of iodised salt and the early detection of thyroid disease.


METHODS
437 people in the municipality of Armenia (Quindío) participated in the study. ELISA tests were performed for free thyroxine, thyroid-stimulating hormone and thyroid peroxidase antibodies; a photocolorimetric analysis was carried out to determine urinary iodine levels.


RESULTS
Hypothyroidism prevalence was 18.5%. Thyroid peroxidase antibodies were positive in 28.9% of the study population, with significantly higher prevalence amongst those with levels > 10 mIU/mL thyroid-stimulating hormone compared to 5.1 to 10 mIU/mL in those without it (OR 3.2) and smokers (O.R 3,4). Free thyroxine was normal in 98.2% of participants (> 5 mIU/mL thyroid-stimulating hormone levels) and 92% in those in whom > 10 mIU/mL thyroid-stimulating hormone levels were found. The average iodine level was 565.1; levels above 300 µg/L were obtained in 81.8% of the participants.


CONCLUSIONS
Increased positive thyroid peroxidase antibody prevalence with increasing thyroid-stimulating hormone values could demonstrate a high risk of developing autoimmune hypothyroidism in Armenia; despite high iodine levels, a relationship with thyroid peroxidase antibodies or thyroid-stimulating hormone levels could not be established.
Facultad Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia. angelalilianal@uniquindio.edu.co
Ángela L
ÁL
Londoño
Marta L
ML
Gallego
Adolfo
A
Bayona
Patricia
P
Landázuri
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D003105:Colombia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology* / Q000652:urine; D007453:Iodide Peroxidase / Q000276:immunology; D007455:Iodine / Q000652:urine*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000453:epidemiology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000453:epidemiology* / Q000652:urine; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014505:Urban Population
D001323:Autoantibodies; D001324:Autoantigens; C056626:thyroid microsomal antibodies; D013972:Thyrotropin; D007455:Iodine; D007453:Iodide Peroxidase; D013974:Thyroxine