Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: case report and review of literature.
A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia.
University of Kragujevac, Faculty of Medicine, Kragujevac, Serbia. vdvd@mailcity.com
Vladimir
V
Jurisic
Natasa
N
Colovic
Tatjana
T
Terzic
Vesna
V
Djordjevic
Milica
M
Colovic
D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20; D020732:Cytogenetic Analysis; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000235:genetics / Q000276:immunology / Q000473:pathology*