A case series of the management of symptomatic azole-resistant candida.
Patients with symptomatic azole-resistant Candida albicans or non-albicans candida are difficult to manage. Treatment is largely anecdotal due to the relatively small number of patients. We present six case reports which highlight our own observation in clinical practice including four patients who were treated successfully with topical amphotericin B/flucytosine vaginal gel for 14 days (Stoke-on-Trent formula).
GUM Department, Derriford Hospital, Plymouth PL6 8DH, UK. rachel@challenor.biz
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Challenor
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Pinsent
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Ekanayaka
D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage; D055815:Young Adult
D000935:Antifungal Agents; D001393:Azoles; D014622:Vaginal Creams, Foams, and Jellies; D000666:Amphotericin B; D005437:Flucytosine