Moderate hyperprolactinemia is associated with survival in patients with acute graft-versus-host disease after allogeneic stem cell transplantation.
Fasting serum prolactin (PRL) levels in response to metoclopramide (MCP) and lymphocyte cytokine profiles was studied in patients given allografts and their donors. Thirty normoprolactinemic volunteers (12-59 years) were studied: group 1, 10 healthy men; group 2, 8 males and 2 females with various hematologic diseases; and group 3, 3 males and 7 females HLA-identical sibling donors: PRL and cytokines were measured. Four surviving recipients developed acute graft-versus-host disease (GVHD) (+), and six did not. Before transplant Fasting PRL concentrations were higher in 'future' GVHD(+) recipients than in their donors (P < 0.001). The opposite was seen in response to MCP (P = 0.01). Donors had a predominant T-helper type 1 (Th1) cytokine profile compared with recipients (P ≤ 0.02), and GVHD(+) recipients had a greater tumor necrosis factor (TNF) value than GVHD(-) (P = 0.05). After transplant On days +30 and +100, a mild sustained rise in fasting PRL levels occurred only in GVHD(+) recipients (P ≤ 0.05) simultaneously with a transient rise in Th1 cytokines. GVHD(-) recipients had no changes. Donors with a Th1 cytokine profile might be more prone to induce GVHD in their recipients, and a mild sustained rise in PRL concentrations after transplantation in recipients GVHD(+) might participate in the amelioration of the severity of GVHD.
Instituto Nacional de Perinatología, Mexico City, Mexico.
Adalberto
A
Parra
Jorge
J
Ramírez-Peredo
Enrique
E
Reyes
Rocío
R
Hidalgo
Julio
J
Macías-Gallardo
Julia
J
Lutz-Presno
Alejandro
A
Ruiz-Argüelles
Eduardo
E
Garza
Eduardo
E
Infante
César H
CH
Gutiérrez-Aguirre
Rosario
R
Salazar-Riojas
Jesús Z
JZ
Villarreal
David
D
Gómez-Almaguer
Guillermo J
GJ
Ruiz-Argüelles
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D016207:Cytokines / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology* / Q000401:mortality; D006680:HLA Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000276:immunology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood / Q000276:immunology*; D012720:Severity of Illness Index; D035781:Siblings; D015996:Survival Rate; D058408:Th1-Th2 Balance; D014019:Tissue Donors; D014184:Transplantation, Homologous
D016207:Cytokines; D006680:HLA Antigens; D011388:Prolactin