[Activity of the NO-system in lung after pulmonectomy of various volumes].
The study was designed to evaluate the activity of NO-system in lung after resection of various volumes. White male rats, subjected to left or right pulmonectomy, were used. Activity of the NO-system in lung was estimated as a difference in the contents of its metabolites (nitrates NO3(-) and nitrites NO2(-)), peroxynitrite (ONOO(-)), activity of endothelial (eNOS) and induced enzyme (iNOS), in arterial and venous blood for 3, 7, 14 day after pulmonectomy. It was revealed, that with the increase of a resections volume, activity of NO-system was reduced. Difference in parameters of NO-system activity in arterial and venous blood reflects endothelial dysfunctions in lung, and can be used as diagnostic criterion.
Sh U
ShU
Babaiarova
A O
AO
Okhunov
A S
AS
Komarin
D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D008168:Lung / Q000378:metabolism* / Q000601:surgery*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D051381:Rats
D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat