Outcome of extremely preterm infants (<1,000 g) with congenital heart defects from the National Institute of Child Health and Human Development Neonatal Research Network.
Little is known about the outcomes of extremely low birth weight (ELBW) preterm infants with congenital heart defects (CHDs). The aim of this study was to assess the mortality, morbidity, and early childhood outcomes of ELBW infants with isolated CHD compared with infants with no congenital defects. Participants were 401-1,000 g infants cared for at National Institute of Child Health and Human Development Neonatal Research Network centers between January 1, 1998, and December 31, 2005. Neonatal morbidities and 18-22 months' corrected age outcomes were assessed. Neurodevelopmental impairment (NDI) was defined as moderate to severe cerebral palsy, Bayley II mental or psychomotor developmental index <70, bilateral blindness, or hearing impairment requiring aids. Poisson regression models were used to estimate relative risks for outcomes while adjusting for gestational age, small-for-gestational-age status, and other variables. Of 14,457 ELBW infants, 110 (0.8 %) had isolated CHD, and 13,887 (96 %) had no major birth defect. The most common CHD were septal defects, tetralogy of Fallot, pulmonary valve stenosis, and coarctation of the aorta. Infants with CHD experienced increased mortality (48 % compared with 35 % for infants with no birth defect) and poorer growth. Surprisingly, the adjusted risks of other short-term neonatal morbidities associated with prematurity were not significantly different. Fifty-seven (52 %) infants with CHD survived to 18-22 months' corrected age, and 49 (86 %) infants completed follow-up. A higher proportion of surviving infants with CHD were impaired compared with those without birth defects (57 vs. 38 %, p = 0.004). Risk of death or NDI was greater for ELBW infants with CHD, although 20 % of infants survived without NDI.
Department of Pediatrics, Children's Hospital of Michigan and Hutzel Women's Hospital, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA. apappas@med.wayne.edu
Athina
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Pappas
Seetha
S
Shankaran
Nellie I
NI
Hansen
Edward F
EF
Bell
Barbara J
BJ
Stoll
Abbot R
AR
Laptook
Michele C
MC
Walsh
Abhik
A
Das
Rebecca
R
Bara
Ellen C
EC
Hale
Nancy S
NS
Newman
Nansi S
NS
Boghossian
Jeffrey C
JC
Murray
C Michael
CM
Cotten
Ira
I
Adams-Chapman
Shannon
S
Hamrick
Rosemary D
RD
Higgins
D016009:Chi-Square Distribution; D002658:Developmental Disabilities / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology* / Q000601:surgery; D017052:Hospital Mortality; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D054582:National Institute of Child Health and Human Development (U.S.); D016012:Poisson Distribution; D014481:United States / Q000453:epidemiology