Savant Genome Browser 2: visualization and analysis for population-scale genomics.
High-throughput sequencing (HTS) technologies are providing an unprecedented capacity for data generation, and there is a corresponding need for efficient data exploration and analysis capabilities. Although most existing tools for HTS data analysis are developed for either automated (e.g. genotyping) or visualization (e.g. genome browsing) purposes, such tools are most powerful when combined. For example, integration of visualization and computation allows users to iteratively refine their analyses by updating computational parameters within the visual framework in real-time. Here we introduce the second version of the Savant Genome Browser, a standalone program for visual and computational analysis of HTS data. Savant substantially improves upon its predecessor and existing tools by introducing innovative visualization modes and navigation interfaces for several genomic datatypes, and synergizing visual and automated analyses in a way that is powerful yet easy even for non-expert users. We also present a number of plugins that were developed by the Savant Community, which demonstrate the power of integrating visual and automated analyses using Savant. The Savant Genome Browser is freely available (open source) at www.savantbrowser.com.
Department of Computer Science, University of Toronto, Ontario, Canada M5S 2E4.
Marc
M
Fiume
Eric J M
EJ
Smith
Andrew
A
Brook
Dario
D
Strbenac
Brian
B
Turner
Aziz M
AM
Mezlini
Mark D
MD
Robinson
Shoshana J
SJ
Wodak
Michael
M
Brudno
D003196:Computer Graphics; D023281:Genomics / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing; D054643:INDEL Mutation; D020407:Internet; D020641:Polymorphism, Single Nucleotide; D011153:Population / Q000235:genetics; D012984:Software