The expression and distribution of xenogeneic targeted antigens on porcine bone tissue.
OBJECTIVE
The objective of this study was to investigate the distribution of α-galactosyl (α-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue.


METHODS
Distribution of α-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry.


RESULTS
α-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells.


CONCLUSIONS
α-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.
Bone and Joint Department of the First Hospital, Jilin University, Jilin, China. doctorfengwei@126.com
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D000818:Animals; D015478:Antigens, Heterophile / Q000032:analysis*; D001854:Bone Marrow Cells / Q000276:immunology; D016025:Bone Transplantation / Q000276:immunology; D001842:Bone and Bones / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007150:Immunohistochemistry; D010006:Osteoblasts / Q000276:immunology; D010011:Osteocytes / Q000276:immunology; D013552:Swine; D014183:Transplantation, Heterologous; D014312:Trisaccharides / Q000032:analysis
D015478:Antigens, Heterophile; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D014312:Trisaccharides; C076569:alpha-galactosyl epitope