Peripheral tissue oxygenation during standard CPB and miniaturized CPB (direct oxymetric tissue perfusion monitoring study).
OBJECTIVE
The aim of this study was to compare the impact of standard cardiopulmonary bypass (CPB) with mini CPB on peripheral tissue perfusion.


METHODS
24 patients with ischemic heart disease scheduled for CPB were randomised to two groups: Group A (12 patients, standard CPB) and Group B (12 patients, mini CPB). Oxygen tension was measured with an optical multiparametric sensor inserted into the patient's deltoid muscle.


RESULTS
Lower priming in Group B (870 ± 221 mL) vs. Group A (1502 ± 48 mL) and significantly reduced hemodilution during mini CPB (Group B 25.3 ± 1.1% vs. Group A 30.1 ± 2.3%) were recorded. Higher and continuous blood flow during perfusion was analysed in Group A (4.58 ± 0.34 L.min(-1)) and lower than calculated blood flow was found in Group B (3.49 ± 0.51 L.min(-1) vs. 4.66 ± 0.38 L.min(-1)). There was a direct correlation between mean arterial pressure (MAP) and ptO2 in Group A during CPB and a direct correlation between pump blood flow and MAP during CPB in Group B. Higher levels of ptO2 during CPB and surgery after CPB in comparison with initial levels were found in Group B. Decreased ptO2 levels after surgery were found in both groups.


CONCLUSIONS
Mini CPB enables perfusion with a relatively low flow. The results of this study suggest that a flow decrease in mini CPB is well tolerated by the organism.
Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic. jiri.mandak@centrum.cz
Jiri
J
Mandak
Vladimir
V
Brzek
Vladimir
V
Svitek
Martin
M
Dergel
James
J
Lago Chek
Martin
M
Volt
Miroslav
M
Horak
Jaroslav
J
Kubicek
Vladimir
V
Lonsky
D000368:Aged; D062186:Arterial Pressure; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods*; D057645:Deltoid Muscle / Q000098:blood supply*; D017558:Elective Surgical Procedures / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010865:Pilot Projects; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012494:Sampling Studies
D010100:Oxygen