An energy-failure based brain edema concept.
Brain edema concepts comprised interstitial, cytotoxic and vasogenic edema as three separate concepts. This is a theory of initiation of brain edema genesis arising from the neuron's cellular metabolism on the basis of energy failure by relative hyperglycolysis and resulting lactacidosis. It can describe edema genesis in trauma, hemorrhage, stroke and infections.
Department of Neurosurgery, University Leipzig, Germany. preuss@kinderneurochirurgie-leipzig.de
Matthias
M
Preuss
D000140:Acidosis, Lactic / Q000150:complications* / Q000378:metabolism*; D000818:Animals; D001929:Brain Edema / Q000150:complications* / Q000378:metabolism*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*
D019344:Lactic Acid; D005947:Glucose