Downregulation of IRS-1 promotes metastasis of head and neck squamous             cell carcinoma.
Lymph node metastasis is responsible for the high morbidity of head and             neck squamous cell carcinoma (HNSCC). To date, the role of insulin receptor substrate 1             (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated.             In this study, we found a negative correlation of IRS-1 expression with tumor             metastasis both in human tissue samples and in cell lines. Furthermore, we found             that knockdown of IRS-1 expression enhanced cell invasive potency and induced             EMT in parallel with upregulation of miR-9 expression. We propose that IRS-1 suppresses             metastasis of head and neck cancer possibly through miR-9.
Department of Pharmacology, Nanjing Medical University, and Department of Pathology, Nanjing First Hospital, Nanjing, Jiangsu, PR China.
Xuan
X
Luo
Songqing
S
Fan
Wenbin
W
Huang
Sulan
S
Zhai
Zhuo
Z
Ma
Ping
P
Li
Shi-Yong
SY
Sun
Xuerong
X
Wang
D000328:Adult; D000368:Aged; D000818:Animals; D015820:Cadherins / Q000096:biosynthesis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D015331:Cohort Studies; D015536:Down-Regulation; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D005260:Female; D055785:Gene Knockdown Techniques; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D055504:Insulin Receptor Substrate Proteins / Q000096:biosynthesis* / Q000235:genetics; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D000077195:Squamous Cell Carcinoma of Head and Neck
D015820:Cadherins; D055504:Insulin Receptor Substrate Proteins; C541874:MIRN92 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger