Impact of admission anemia, C-reactive protein and mean platelet volume on short term mortality in patients with acute ST-elevation myocardial infarction treated with primary angioplasty.
OBJECTIVE
To investigate admission anemia, C-reactive protein (CRP) and mean platelet volume (MPV) together as prognostic markers in ST-elevation myocardial infarction (STEMI).


METHODS
Baseline hemoglobin, CRP and MPV were determined in 543 patients with acute STEMI to whom primary angioplasty was performed and evaluated for short term mortality (30 days).


RESULTS
After multivariate analysis anemia (odds ratio 2.69, 95% confidence interval 1.24-5.86) and CRP (odds ratio 3.40, 95% confidence interval 1.13-10.22) remained significant independent predictors of short-term mortality. Addition of anemia and CRP to PAMI risk score improved prediction of short-term outcome; area under ROC curve rose from 0.76 to 0.87 (p<0.001).


CONCLUSIONS
Better ability to determine 30-day mortality was obtained when anemia and CRP were incorporated into the PAMI risk score.
School of Medicine, University of Zagreb, Croatia. mislav.vrsalovic@zg.t-com.hr
Mislav
M
Vrsalovic
Hrvoje
H
Pintaric
Zdravko
Z
Babic
Marin
M
Pavlov
Ana
A
Vrsalovic Presecki
Biserka
B
Getaldic
Nada
N
Vrkic
Vjeran
V
Nikolic Heitzler
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood* / Q000150:complications / Q000401:mortality; D015906:Angioplasty, Balloon, Coronary; D001792:Blood Platelets / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism*; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D010343:Patient Admission; D011379:Prognosis; D012372:ROC Curve; D012306:Risk; D016019:Survival Analysis
D002097:C-Reactive Protein