Longitudinal comparison of diffusion tensor imaging parameters and neuropsychological measures following endoscopic third ventriculostomy for hydrocephalus.
The authors report the case of a 25-month-old boy who underwent endoscopic third ventriculostomy (ETV) for hydrocephalus resulting from aqueductal stenosis. The patient's recovery was monitored longitudinally and prospectively using MR diffusion tensor imaging (DTI) and formal neuropsychological testing. Despite minimal change in ventricle size, improvement in the DTI characteristics and neurodevelopmental trajectory was observed following ETV. These data support the use of DTI as a biomarker to assess therapeutic response in children undergoing surgical treatment for hydrocephalus. In the patient featured in this report, DTI appeared to provide more information regarding postoperative neurodevelopmental outcome than ventricle size alone.
Departments of Neurological Surgery, St. Louis Children’s Hospital, Washington University School of Medicine in St. Louis, MO, USA. buckleyr@wusm.wustl.edu
Robert T
RT
Buckley
Weihong
W
Yuan
Francesco T
FT
Mangano
Jannel M
JM
Phillips
Stephanie
S
Powell
Robert C
RC
McKinstry
Akila
A
Rajagopal
Blaise V
BV
Jones
Scott
S
Holland
David D
DD
Limbrick
D002657:Child Development; D056324:Diffusion Tensor Imaging; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D044583:Neuroendoscopy; D009483:Neuropsychological Tests; D020542:Third Ventricle / Q000601:surgery; D014696:Ventriculostomy