Detection of MAGE-A expression predicts malignant transformation of oral leukoplakia.
The study aimed at checking if MAGE-A expression in oral leukoplakia (OLP) lesions is related to malignant transformation. The 48 samples of OLP that transformed to oral squamous cell carcinoma (OSCC) (group 1) and 50 samples of OLP that did not transform to OSCC (group 2) were included in the study. The expression of MAGE-A was restricted to group 1. The correlation between malignant transformation and MAGE-A occurrence in OLP was statistically significant (p < .0001). Detection of MAGE-A may allow identifying OLP with a high risk of malignant transformation giving a view to a new approach to prevention of oral cancer.
Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Germany. jutta.ries@uk-erlangen.de
Jutta
J
Ries
Abbas
A
Agaimy
Elefterios
E
Vairaktaris
Patricia
P
Gorecki
Friedrich W
FW
Neukam
Lei H
LH
Strassburg
Emeka
E
Nkenke
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000473:pathology*; D008297:Male; D058950:Melanoma-Specific Antigens / Q000032:analysis*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology
D058950:Melanoma-Specific Antigens