HPV-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification.
Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers.
School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. kimplead@gmail.com
Adam J
AJ
Kimple
Alexandra D
AD
Torres
Robert Z
RZ
Yang
Randall J
RJ
Kimple
D015139:Blotting, Southern; D006258:Head and Neck Neoplasms / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D014412:Tumor Virus Infections / Q000821:virology*