fMRI evaluation of cochlear implant candidacy in diffuse cortical cytomegalovirus disease.
Congenital cytomegalovirus infection is the most frequent nongenetic cause of pediatric hearing loss in the United States, affecting approximately 8,000 children each year. Due in part to variable cytomegalic involvement of the auditory cortex, cochlear implantation outcomes have varied widely. Functional magnetic resonance imaging (fMRI) has the potential to assist in determining candidacy for cochlear implantation through the detection of intact auditory pathways including the cortex. We report a case of a 21-month-old girl with cytomegalovirus-related deafness and diffuse white matter involvement in which fMRI was a determining factor for cochlear implantation and side selection.
Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, USA.
Joshua P
JP
Weiss
Byron
B
Bernal
Thomas J
TJ
Balkany
Nolan
N
Altman
Dan
D
Jethanamest
Erin
E
Andersson
D001303:Auditory Cortex / Q000473:pathology* / Q000821:virology; D019929:Cochlear Implantation / Q000009:adverse effects / Q000379:methods*; D003054:Cochlear Implants; D003587:Cytomegalovirus / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000601:surgery* / Q000821:virology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018579:Patient Selection; D011300:Preoperative Care / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014766:Viremia / Q000150:complications / Q000175:diagnosis / Q000601:surgery