Proliferative and nonproliferative lesions of the rat and mouse central and peripheral nervous systems.
Harmonization of diagnostic nomenclature used in the pathology analysis of tissues from rodent toxicity studies will enhance the comparability and consistency of data sets from different laboratories worldwide. The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of four major societies of toxicologic pathology to develop a globally recognized nomenclature for proliferative and nonproliferative lesions in rodents. This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems. Sources of material include academic, government, and industrial histopathology databases from around the world. Covered lesions include frequent, spontaneous, and aging-related changes as well as principal toxicant-induced findings. Common artifacts that might be confused with genuine lesions are also illustrated. The neural nomenclature presented in this document is also available electronically on the Internet at the goRENI website (http://www.goreni.org/).
Merck KGaA, Darmstadt, Germany. wolfgang.kaufmann@merckgroup.com
Wolfgang
W
Kaufmann
Brad
B
Bolon
Alys
A
Bradley
Mark
M
Butt
Stephanie
S
Czasch
Robert H
RH
Garman
Catherine
C
George
Sibylle
S
Gröters
Georg
G
Krinke
Peter
P
Little
Jenny
J
McKay
Isao
I
Narama
Deepa
D
Rao
Makoto
M
Shibutani
Robert
R
Sills
D000818:Animals; D002493:Central Nervous System Diseases / Q000145:classification / Q000473:pathology*; D051379:Mice; D010523:Peripheral Nervous System Diseases / Q000145:classification / Q000473:pathology*; D051381:Rats; D009626:Terminology as Topic; D018675:Toxicity Tests