One-pot synthesis of β-acetamido ketones using boric acid at room temperature.
β-acetamido ketones were synthesized in excellent yields through one-pot condensation reaction of aldehydes, acetophenones, acetyl chloride, and acetonitrile in the presence of boric acid as a solid heterogeneous catalyst at room temperature. It is the first successful report of boric acid that has been used as solid acid catalyst for the preparation of β-acetamido ketones. The remarkable advantages offered by this method are green catalyst, mild reaction conditions, simple procedure, short reaction times, and good-to-excellent yields of products.
Department of Chemistry, Firoozabad Branch, Islamic Azad University, P.O. Box 74715-117, Fars, Firoozabad, Iran. zahed.karimi@yahoo.com
Zahed
Z
Karimi-Jaberi
Korosh
K
Mohammadi
D001888:Boric Acids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013696:Temperature
D001888:Boric Acids; D007659:Ketones; C032688:boric acid