Endoscopic therapies for Barrett's-associated dysplasia: a new paradigm for a new decade.
The emergence of endoscopic therapies for Barrett's esophagus (BE)-associated dysplasia has significantly altered the management of this complex disease. Over the past decade, there has been a paradigm shift from that of pure surveillance to a more therapeutic approach in eradicating dysplastic BE. This strategy includes less invasive options than esophagectomy for high-grade dysplasia and early eradication of confirmed low-grade dysplasia. Although multiple modalities exist for endoscopic therapy, endoscopic mucosal resection coupled with radiofrequency ablation appears to be the most effective therapy, with minimal complications. Recent advances in endoscopic eradication therapies for dysplastic BE have fueled excitement for a significant weapon against the rising incidence of esophageal cancer.
Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. koman1973@gmail.com
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D001471:Barrett Esophagus / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods; D017679:Cryotherapy / Q000009:adverse effects / Q000379:methods; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods* / Q000639:trends*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*