Macrophage, mast cell and T lymphocyte infiltrations are independent predictive biomarkers of primary refractoriness or early relapse in classical Hodgkin lymphoma.
Tumor-associated macrophages (TAMs) might be associated with worse outcome in classical Hodgkin lymphoma (cHL). Our aim was to determine whether TAMs correlated with refractoriness in cHL. In a cohort of 18 consecutive primary refractory or early relapsed cases and 41 randomly selected controls (responder patients), high TAM infiltration was significantly associated with refractoriness or early relapse (p = 0.004) and remained independently correlated with outcome in multivariate analysis (odds ratio 8.276, 95% confidence interval 1.214-56.408). This study provides evidence that the marker CD68 might accurately predict early outcome of de novo cHL and could be used in combination with c-kit and TiA1 staining.
Department of Hematology, Paris Descartes University, Hôpital Necker, Paris, France. benedicte.deau-fischer@cch.aphp.fr
Bénédicte
B
Deau
Emmanuel
E
Bachy
Vincent
V
Ribrag
Richard
R
Delarue
Marie Thérèse
MT
Rubio
Jacques
J
Bosq
Bruno
B
Varet
Nicole
N
Brousse
Olivier
O
Hermine
Danielle
D
Canioni
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D014408:Biomarkers, Tumor; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D039102:Poly(A)-Binding Proteins / Q000378:metabolism; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012008:Recurrence; D000074019:T-Cell Intracellular Antigen-1; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000276:immunology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D039102:Poly(A)-Binding Proteins; D019009:Proto-Oncogene Proteins c-kit; D000074019:T-Cell Intracellular Antigen-1; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C071558:TIA1 protein, human