Pulmonary metastatic giant cell tumors presenting as totally hyalinized and ossified nodules.
We report a case of giant cell tumor of the left distal femur with simultaneous bilateral pulmonary metastases. Pathologic examination of the left lung nodule showed a metastatic giant cell tumor with a noncontinuous ossified rim, and the right lung nodules were totally hyalinized or ossified without residual giant cell tumor components. Hyalinization was a consistent finding in both the primary bone lesion and the pulmonary metastases. Because the patient did not receive chemotherapy or radiotherapy before her surgical procedure, we believe that these changes represent spontaneous tumor regression.
Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Min-Shu
MS
Hsieh
Chen-Tu
CT
Wu
Mong-Wei
MW
Lin
Yih-Leong
YL
Chang
Yung-Chie
YC
Lee
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005269:Femur / Q000473:pathology; D005500:Follow-Up Studies; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D006801:Humans; D006818:Hyalin; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D055613:Multiple Pulmonary Nodules / Q000473:pathology / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009365:Neoplasm Regression, Spontaneous; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D011013:Pneumonectomy; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed