Plasmid-mediated quinolone resistance in extended-spectrum-β-lactamase- and AmpC β-lactamase-producing Serratia marcescens in China.
We investigated the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and examined the association of these determinants with extended-spectrum β-lactamases (ESBLs) and/or plasmid-mediated AmpC β-lactamases (pAmpCs) in Serratia marcescens isolates in China. In this study, the presence of PMQR determinants was significantly related to the coproduction of ESBLs and/or pAmpCs (CTX-M-14, SHV-5, DHA-1, and ACT-1), among which CTX-M-14 was the most common gene type.
Department of Infectious Disease, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hai-Fei
HF
Yang
Jun
J
Cheng
Li-Fen
LF
Hu
Ying
Y
Ye
Jia-Bin
JB
Li
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D002681:China; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D015363:Quinolones / Q000494:pharmacology*; D016868:Serratia Infections / Q000188:drug therapy / Q000382:microbiology; D012706:Serratia marcescens / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D002939:Ciprofloxacin; D015242:Ofloxacin; C456080:beta-lactamase CTX-M-14; C048795:AmpC beta-lactamases; D001618:beta-Lactamases