Effects of glucomannan on the sacculus rotundus and peripheral blood lymphocytes in New Zealand rabbits during aflatoxicosis.
This study was aimed to determine the effects of the glucomannan added to aflatoxin- (AF-) contaminated diet on the sacculus rotundus and peripheral blood lymphocytes of New Zealand rabbits by histological and enzyme histochemical methods. Twenty-four adult rabbits of both sexes were divided into four equal groups, namely, as control, glucomannan 0.2 g/day, AF 125 μg/kg/day, and glucomannan combined with AF. The animals in all groups were treated for 12 weeks by the above-mentioned diet. When compared to control, AF-treatment caused significant decrease in alpha-naphthyl acetate esterase- (ANAE-) positive peripheral blood lymphocyte (PBL) percentages. The addition of the glucomannan to AFcontaining diet recovered the adverse effects of AF on sacculus rotundus and increased the ANAE-positive PBL counts. These results suggested that glucomannan was effective against the negative effects of AF in rabbits.
Department of Histology, Selçuk University Veterinary Faculty, 42031 Konya, Turkey.
Emrah
E
Sur
Hasan Hüseyin
HH
Dönmez
Murat
M
Boydak
Mehmet Bozkurt
MB
Ataman
D000348:Aflatoxins / Q000097:blood* / Q000633:toxicity*; D000821:Animal Feed; D000818:Animals; D001230:Aspergillus / Q000378:metabolism; D004950:Esterases / Q000096:biosynthesis; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects; D007150:Immunohistochemistry / Q000379:methods; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology*; D015233:Models, Statistical; D009284:Naphthols / Q000737:chemistry; D011817:Rabbits; D012107:Research Design
D000348:Aflatoxins; D008351:Mannans; D009284:Naphthols; C005366:naphthyl acetate; C022901:(1-6)-alpha-glucomannan; D004950:Esterases