Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.
This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. kouno@surg2.med.kyushu-u.ac.jp
Mikihiro
M
Kohno
Ken
K
Shirabe
Yohei
Y
Mano
Jun
J
Muto
Takashi
T
Motomura
Kazuki
K
Takeishi
Takeo
T
Toshima
Masanori
M
Yoshimatsu
Hideki
H
Ijichi
Noboru
N
Harada
Shinichi
S
Aishima
Hideaki
H
Uchiyama
Tomoharu
T
Yoshizumi
Akinobu
A
Taketomi
Yoshihiko
Y
Maehara
D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism
D014408:Biomarkers, Tumor; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor