Antinucleosome antibodies and primary antiphospholipid syndrome: an observational study.
OBJECTIVE
To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up.


METHODS
Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-NCS/chromatin antibodies.


RESULTS
After a mean follow-up period of 45.7 months, anti-NCS/chromatin antibodies were detected in only one patient (2.8%), who developed features of SLE including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profile suggestive of SLE.


CONCLUSIONS
The frequency of anti-NCS/chromatin antibodies in primary APS patients is very low, and they may be associated with the development of SLE manifestations.
Universidade Federal de São Paulo – Unifesp.
Alexandre Wagner Silva
AW
de Souza
Silene Peres
SP
Keusseyan
Neusa Pereira
NP
da Silva
Emilia Inoue
EI
Sato
Luis Eduardo Coelho
LE
Andrade
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology*; D009707:Nucleosomes / Q000276:immunology*; D011446:Prospective Studies
D001323:Autoantibodies; D009707:Nucleosomes