Syntheses and antibacterial activity of Schiff bases from 16-isopropyl-5, 9-dimethyltetracyclo [10.2.2.0(1, 10).0(4, 9)] hexadec-15-ene-5, 14-dicarboxylic acid.
16-isopropyl-5, 9-dimethyltetracyclo [10.2.2.0(1, 10).0(4, 9)] hexadec-15-ene-5, 14-dicarboxylic acid (1b) was prepared from rosin through a Diels-Alder addition reaction. Then, a group of Schiff bases derived from 1b was synthesised. Their structures were characterised by IR,(1)H-NMR, MS and elemental analysis. The antibacterial activities of these newly synthesised Schiff bases were also investigated. The results show that these compounds possess antibacterial activities against Staphylococcus aureus and Escherichia coli. Among them, compounds 5a, 5b and 5c, exhibit remarkable antibacterial activity against E. coli.
Institute of Chemical Industry of Forest Products, CAF, Jiangsu Province, China.
Jian
J
Li
Jie
J
Song
Shi-Bin
SB
Shang
Xiao-Ping
XP
Rao
Yan-Qing
YQ
Gao
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
C586229:16-isopropyl-5, 9-dimethyltetracyclo(10.2.2.0(1,10).0(4,9))hexadec-15-ene-5,14-dicarboxylic acid; D000900:Anti-Bacterial Agents; D011083:Polycyclic Compounds; D012116:Resins, Plant; D012545:Schiff Bases; C013893:rosin