Bronchiolitis obliterans organising pneumonia: a consequence of breast radiotherapy.
The authors describe a case of 51-year-old woman who presented with breathlessness following radiotherapy for breast carcinoma. A chest radiograph and thoracic CT scan revealed extensive airspace consolidation affecting right upper and lower lobes. A trans-bronchial biopsy revealed evidence of foamy macrophages and fibroblastic plugs within alveoli, consistent with organising pneumonia. Indirect immunofluorescence microscopy revealed evidence of antiepithelial antibodies. Gradual but complete resolution occurred without any specific treatment. This case highlights the importance of considering radiation induced bronchiolitis obliterans organising pneumonia in the context of parenchymal shadowing following radiotherapy. Although corticosteroids are widely recommended for treatment, this case illustrates that organising pneumonia may resolve spontaneously.
Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, UK. ahmedfahim@doctors.org.uk
Ahmed
A
Fahim
Anne P
AP
Campbell
Simon Paul
SP
Hart
D001943:Breast Neoplasms / Q000532:radiotherapy*; D002277:Carcinoma / Q000532:radiotherapy*; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed