Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2).
BACKGROUND
Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings.


METHODS
Male, 48 years old, with an aura that included complex illusions with a feeling of time travelling, coincident with other aura features. The aura was regarded as mystical by the patient. Female, 38 years old, with a complex migraine aura, during which she believed she had the ability to time travel and was being followed by lobbyists who wanted to steal this ability from her.


CONCLUSIONS
FHM type 2 must be included in the list of differential diagnoses of acute psychosis in patients with a previous history of migraine aura.
Serviço de Neurologia, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Largo Professor Abel Salazar, 4099-001 Porto, Portugal, josebarros.neuro@hgsa.min-saude.pt
José
J
Barros
Alexandre
A
Mendes
Ilda
I
Matos
José
J
Pereira-Monteiro
D000293:Adolescent; D000328:Adult; D002648:Child; D004827:Epilepsy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications* / Q000235:genetics; D009154:Mutation; D010375:Pedigree; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D055815:Young Adult
C498531:ATP1A2 protein, human; D000254:Sodium-Potassium-Exchanging ATPase