Unusual terpenylated acylphloroglucinols from Dryopteris wallichiana.
Four unusual terpenylated acylphloroglucinols were isolated from the diethyl ether extract of the scales and rhizomes of the fern Dryopteris wallichiana together with the known compounds albaspidins AA and AB, and filixic acids ABA and ABB. Structures of the isolated compounds were established by extensive spectroscopic analysis and their absolute configuration at C-14″ was determined by comparing their CD spectra with those simulated for the respective isomers. Pure acylphloroglucinols displayed moderate in vitro nematocidal activity against L4 stage larvae of Nippostrongylus brasiliensis (LD₅₀=22-121 μM).
INQUINOA-CONICET, Ayacucho 471, Tucumán 4000, Argentina. csocolsky@fbqf.unt.edu.ar
Cecilia
C
Socolsky
Laura
L
Domínguez
Yoshinori
Y
Asakawa
Alicia
A
Bardón
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D032492:Dryopteris / Q000737:chemistry*; D008018:Life Cycle Stages / Q000187:drug effects; D009559:Nippostrongylus / Q000187:drug effects / Q000254:growth & development; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000969:Antinematodal Agents; D013729:Terpenes