New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Seung Ill
SI
Kim
Seung Ho
SH
Lee
Eung-Seok
ES
Lee
Chong-Soon
CS
Lee
Yurngdong
Y
Jahng
D045744:Cell Line, Tumor; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D027821:Rutaceae; D059004:Topoisomerase I Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D052999:Quinazolinones
D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II; D026121:Indole Alkaloids; D011799:Quinazolines; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C028632:rutecarpine; D052999:Quinazolinones