[Early and late mortality of patients with community acquired pneumonia].
Community acquired pneumonia is the most frequent infective cause of severe sepsis and death. The risk of mortality in community acquired pneumonia is predictable by the "pneumonia severity index" and various biomarkers (e.g., procalcitonin, troponin-I). Quantitative testing of pneumococcal load (DNA) in blood has also become possible recently. Early death due to acute myocardial infarction is more frequent among patients with previous community acquired pneumonia. The 1-year and the 5-6 year survival is shorter among these patients. Pro-inflammatory cytokines synthesized during community acquired pneumonia accelerate chronic inflammation ongoing in atherosclerotic plaques. The pro-thrombotic condition present in atherosclerosis is also potentiated by community acquired pneumonia. These pathophysiological mechanisms may explain the epidemiologic fact that community acquired pneumonia is an independent risk factor of cardiovascular mortality.
Semmelweis Egyetem, Általános Orvostudományi Kar Pulmonológiai Klinika, Budapest.
György
G
Losonczy
D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000401:mortality*; D017714:Community-Acquired Infections / Q000401:mortality; D016207:Cytokines / Q000097:blood; D004269:DNA, Bacterial / Q000302:isolation & purification; D006801:Humans; D007249:Inflammation / Q000097:blood; D009203:Myocardial Infarction / Q000401:mortality; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000473:pathology; D011014:Pneumonia / Q000097:blood / Q000401:mortality* / Q000503:physiopathology*; D012307:Risk Factors; D012720:Severity of Illness Index; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000302:isolation & purification*; D013927:Thrombosis / Q000209:etiology / Q000401:mortality; D013997:Time Factors
D015415:Biomarkers; D016207:Cytokines; D004269:DNA, Bacterial