Fatal meningitis caused by vancomycin-resistant enterococci: report of two cases from south India.
Vancomycin-resistant enterococci rarely cause meningitis and present a therapeutic challenge. Antimicrobial susceptibility testing was done for strains of Enterococcus species isolated from CSF samples of patients with meningitis by phenotypic methods. Multiplex polymerase chain reaction was performed to determine the genetic basis of vancomycin resistance of such isolates. We report here two cases of enterococcal meningitis caused by vancomycin-resistant Enterococcus species. One of the isolates was identified as Enterococcus faecalis and the other as Enterococcus gallinarum. We also report the simultaneous presence of vanC1 and vanA resistance genes in the strain of E. gallinarum. To the best of our knowledge, this is the first report of vanA resistance gene in an isolate of E. gallinarum from the Indian subcontinent. This is also the first Indian report of vancomycin-resistant Enterococcus causing meningitis.
Department of Microbiology and Neurosurgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry   605006, India.
I
I
Praharaj
S
S
Sujatha
S C
SC
Parija
M S
MS
Gopalakrishnan
D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D016983:Enterococcus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D005798:Genes, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007194:India; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial