[Effect of the liposomal form of taxifolin complexes with metals of variable valence on skin regeneration after chemical burn].
The effect of the liposomal form formed by taxifolin and metals of variable valency was investigated. It was shown that the application of preparations based on the free flavonoid and its complexes with Fe(II/III) and Cu(II) ions after chemical burns results in a more effective skin regeneration and the repair of hair follicles and sebaceous glands. A tendency for a more effective wound healing after the applications of taxifolin-Cu(II) and taxifolin-Fe(III) liposomal complexes versus control was observed. It was assumed that the mechanism of action of these preparations is based on the oxidative polymerization and conjugation of the flavonoid, which results in the utilization of toxic metabolites and lipid peroxidation products.
V S
VS
Shubina
Iu V
IuV
Shatalin
D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D056831:Coordination Complexes / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry; D018859:Hair Follicle / Q000187:drug effects* / Q000473:pathology; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008297:Male; D010084:Oxidation-Reduction; D058105:Polymerization; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012627:Sebaceous Glands / Q000187:drug effects* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D056831:Coordination Complexes; D008081:Liposomes; D003300:Copper; D011794:Quercetin; C003377:taxifolin; D007501:Iron