Roles of Dppa2 in the regulation of the present status and future of pluripotent stem cells.
Maintenance of undifferentiated states of pluripotent embryonic stem cells is regulated by a complex network of transcription factors and signaling pathways. Recent reports revealed that developmental pluripotency-associated 2 (Dppa2), which regulates chromatin structures, plays important roles in the maintenance of pluripotency and proliferation of embryonic stem cells. Interestingly, developmental pluripotency-associated 2 is involved not only in the normal development of lung but also in the pathogenesis of non-small cell lung cancers. These results suggest that an epigenetic regulator of pluripotent stem cells plays important roles in normal development and tumorigenesis.
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan. t-watabe@umin.ac.jp
Tetsuro
T
Watabe
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D014157:Transcription Factors
D018797:Cell Cycle Proteins; C502836:DPPA2 protein, human; C519286:Dppa2 protein, mouse; C519287:Dppa4 protein, mouse; D009687:Nuclear Proteins; D014157:Transcription Factors