Follow-up of babies born to mothers with antiphospholipid syndrome: preliminary data from the European neonatal registry.
In this review preliminary data on the follow-up of 141 babies born to mothers with antiphospholipid syndrome are reported. In spite of maternal treatment, the rate of both preterm delivery and low birth weight were 16 and 17%, respectively. At birth, no clinical evidence of perinatal thrombosis was observed. Placental transfer of antiphospholipid antibodies occurred in 20, 25 and 43% of cases for lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I antibodies, respectively. At 24 months of follow-up, four children showed behaviour abnormalities suggesting the possible need for long-term neurological evaluation in this clinical setting.
Neonatology and Neonatal Intensive Care Unit, Children's Hospital of Brescia, Italy. mario.motta@spedalicivili.brescia.it
M
M
Motta
M C
MC
Boffa
A
A
Tincani
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T
Avcin
S
S
De Carolis
E
E
Lachassinne
D016736:Antiphospholipid Syndrome / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012042:Registries