[Pharmacological correction of hypoxia in patients with severe carbon monoxide poisoning].
The article deals with the materials, which have been received in the process of the examination and treatment of 44 patients with acute severe methadone poisonings.  It has been revealed, that gravity of these patients' condition depends on the intensity of hypoxia due to breath deficiency because of methadone. The development of hypoxia, in its turn, causes violations of antiradical protection system and intensification of processes of peroxide lipid oxidation. It has been registered that the including of reamberin into the complex program of the intensive therapy of acute severe methadone poisonings leads to a more rapid restoration of antiradical protection system and to a decrease of activity of processes of peroxide lipid oxidation. The correction of hypoxia and free-radical violations led to the improvement of the acute poisonings clinics, what was characterized by a decrease of coma-period duration, duration of treatment with artificial lung ventilation, a decrease of secondary lung complications and a decrease of lethality.
V V
VV
Shilov
A Iu
AIu
Andrianov
S A
SA
Vasil'ev
Kh V
KhV
Batotsyrenova
A T
AT
Loladze
D000328:Adult; D002248:Carbon Monoxide / Q000633:toxicity*; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications / Q000401:mortality / Q000473:pathology / Q000628:therapy; D004338:Drug Combinations; D005260:Female; D005390:Fires; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D006801:Humans; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D012121:Respiration, Artificial; D013386:Succinates / Q000008:administration & dosage*
D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D002248:Carbon Monoxide; D007290:Inosine Diphosphate; D010100:Oxygen