In vivo clearance and toxicity of monodisperse iron oxide nanocrystals.
Thermal decomposition of organometallic precursors has been found to generate highly crystalline iron oxide (IO) nanocrystals that display superior MR contrast and lower polydispersity than IO nanocrystals synthesized by aqueous precipitation. In the present study, the in vivo characteristics of IO nanocrystals prepared by the thermal decomposition route and then coated with a phospholipid containing a pendant poly(ethylene glycol) chain are examined. The size and surface chemistry of the IO nanocrystal influence the biodistibution, the rate of biodegradation and bioclearance, and the biodegradation products. We conclude that the in vivo fate of PEGylated monodisperse IO nanocrystals and the iron, phospholipid, and oleic acid biodegradation products may influence the cellular environments in the organs and blood that can determine their safety in the body.
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
Luo
L
Gu
Ronnie H
RH
Fang
Michael J
MJ
Sailor
Ji-Ho
JH
Park
D000818:Animals; D005290:Ferric Compounds / Q000493:pharmacokinetics* / Q000633:toxicity*; D008422:Materials Testing; D008657:Metabolic Clearance Rate; D053768:Metal Nanoparticles / Q000633:toxicity*; D051379:Mice; D009928:Organ Specificity; D014018:Tissue Distribution
D005290:Ferric Compounds; C000499:ferric oxide