Use of nonsteroidal anti-inflammatory drugs and risk of ovarian and endometrial cancer: the Multiethnic Cohort.
BACKGROUND
Chronic inflammation may play an etiologic role in ovarian and endometrial cancer, and it is hypothesized that nonsteroidal anti-inflammatory drugs (NSAID) decrease the risk of developing these malignancies. No prospective study with a large multiethnic population has explored this hypothesis.


METHODS
We investigated whether NSAID use was associated with risks of ovarian and endometrial cancer in the Multiethnic Cohort Study. Medication use of at least twice a week for ≥1 month was assessed at baseline. Multivariable relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models.


RESULTS
During 13.3 years of follow-up, 275 ovarian and 620 endometrial incident cases were identified among approximately 64,000 women included in this analysis (16.5% African Americans, 30.8% Japanese, 7.7% Native Hawaiians, 18.9%, Latinas, and 26.0% whites). The RR (95% CI) for ovarian cancer associated with aspirin, non-aspirin NSAIDs, and acetaminophen were 0.87 (0.68-1.14), 0.97 (0.74-1.26), and 0.86 (0.67-1.12), respectively. The RR (95% CI) for endometrial cancer associated with aspirin, non-aspirin NSAIDs, and acetaminophen were 0.93 (0.79-1.10), 0.88 (0.74-1.05), and 0.96 (0.81-1.13), respectively. No heterogeneity across ethnic groups (P ≥ 0.29) or dose-response relation with increased duration of use (P(trend) ≥ 0.16) was observed. The results did not differ by tumor histology.


CONCLUSIONS
We found no compelling evidence to support an association between the use of NSAIDs and risk of ovarian and endometrial cancers in a multiethnic population.


CONCLUSIONS
It is unlikely that NSAID is involved in the etiology of endometrial and ovarian cancer.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. vsetiawa@usc.edu
Veronica Wendy
VW
Setiawan
Rayna K
RK
Matsuno
Galina
G
Lurie
Lynne R
LR
Wilkens
Michael E
ME
Carney
Brian E
BE
Henderson
Laurence N
LN
Kolonel
Marc T
MT
Goodman
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000208:ethnology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000208:ethnology / Q000517:prevention & control*; D011446:Prospective Studies; D012306:Risk
D000894:Anti-Inflammatory Agents, Non-Steroidal