Exploration of forbidden Povarov processes as a source of unexpected reactivity: a multicomponent Mannich-Ritter transformation.
When a door closes, a window opens! The use of geometrically or electronically restricted imines for Povarov-type processes does not afford the anti-Bredt tetrahydroquinolines, but leads instead to highly functionalized structures through novel reaction pathways (see picture; LA=Lewis acid). The exploration of "forbidden" routes constitutes a valuable approach in the search for new multicomponent reactions.
Barcelona Science Park, Barcelona, Spain.
Sara
S
Preciado
Esther
E
Vicente-García
Salomé
S
Llabrés
F Javier
FJ
Luque
Rodolfo
R
Lavilla
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D007097:Imines; D058116:Lewis Acids; D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline