Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese.
OBJECTIVE
In Japan, patient acceptance of bowel preparation methods before colonoscopy remains unknown. This study was conducted to evaluate the patient acceptance of sodium phosphate (NaP) tablets and polyethylene glycol solution (PEG) with sodium picosulfate.


METHODS
One hundred patients were randomized into one of the following two groups: the NaP tablet first-use group or the PEG with sodium picosulfate first-use group in a crossover design trial. Patient acceptance and incidence of adverse events were evaluated using a questionnaire. Colon-cleansing effectiveness was also evaluated.


RESULTS
Patients' overall impressions of the preparations were significantly different between the NaP tablet (77.9%, 67/86) and PEG with sodium picosulfate (60.5%, 52/86; P = 0.001). Nausea incidence as an adverse event was significantly different between the two regimens (P = 0.03). Colon-cleansing effectiveness was not significantly different between the two regimens.


CONCLUSIONS
The results of this crossover study showed that patient acceptance was similar to those previously reported in a parallel-group comparison. In Japanese patients, preference for and acceptance of NaP tablets was significantly higher than that for PEG with sodium picosulfate solution.
Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan.
Naoki
N
Hosoe
Manabu
M
Nakashita
Hiroyuki
H
Imaeda
Tomohisa
T
Sujino
Rieko
R
Bessho
Riko
R
Ichikawa
Nagamu
N
Inoue
Takanori
T
Kanai
Toshifumi
T
Hibi
Haruhiko
H
Ogata
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D044466:Asian People / Q000523:psychology*; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002951:Citrates; D003113:Colonoscopy; D018592:Cross-Over Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000208:ethnology; D009942:Organometallic Compounds; D010342:Patient Acceptance of Health Care / Q000208:ethnology*; D057240:Patient Preference / Q000208:ethnology; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010847:Picolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013607:Tablets
D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010710:Phosphates; D010847:Picolines; D013607:Tablets; D011092:Polyethylene Glycols; C005701:picosulfate sodium; C018279:sodium phosphate