Urinary heme oxygenase-1 in children with congenital hydronephrosis due to ureteropelvic junction obstruction.
BACKGROUND
Heme oxygenase-1 (HO-1) is implicated to be correlated with renal function in oxidative stress.


OBJECTIVE
To determine whether urinary (u) HO-1 is associated with the progression of congenital obstructive hydronephrosis (HN).


METHODS
A total 50 children with HN (study group and control 1) and 30 healthy children were enrolled in this study.


RESULTS
The uHO-1/cr levels increased significantly and negatively correlated with split renal function in study group before and during surgery. One month after surgery, it decreased significantly.


CONCLUSIONS
Increased uHO-1 levels could be a potential biomarker for evaluating the progression of obstructive nephropathy.
The Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
ZhenZhen
Z
Li
XiangHua
X
Liu
Shan
S
Liu
ChaoHui
C
Gu
FengYan
F
Tian
JianGuo
J
Wen
D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D051547:Heme Oxygenase-1 / Q000652:urine*; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital / Q000175:diagnosis* / Q000209:etiology; D007223:Infant; D007668:Kidney / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D013997:Time Factors; D014517:Ureteral Obstruction / Q000150:complications*
D015415:Biomarkers; D051547:Heme Oxygenase-1