Beta-carboline alkaloids derived from the ascidian Synoicum sp.
Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y(1) (7) and six new derivatives, designated eudistomins Y(8)-Y(13) (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase. Structure-activity relationships were also deduced.
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea.
Tae Hyung
TH
Won
Ju-Eun
JE
Jeon
So-Hyoung
SH
Lee
Boon Jo
BJ
Rho
Ki-Bong
KB
Oh
Jongheon
J
Shin
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003546:Cysteine Endopeptidases / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D014561:Urochordata / Q000737:chemistry*
D000470:Alkaloids; D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D002243:Carbolines; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D007522:Isocitrate Lyase; D000254:Sodium-Potassium-Exchanging ATPase