Personal glucose sensor for point-of-care early cancer diagnosis.
Early POC diagnosis of cancer is demonstrated by using multi-invertase conjugated microsphere labels and a personal glucose sensor (PGS) transducer. The invertase, which catalyzes the hydrolysis of sucrose to glucose, enables the PGS to detect target analytes beyond glucose, and the numerous invertase labels involved in each antibody-antigen binding event lead to significantly amplified PGS readings for sensitive protein detection.
Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.
Jiao
J
Su
Jin
J
Xu
Ying
Y
Chen
Yun
Y
Xiang
Ruo
R
Yuan
Yaqin
Y
Chai
D000936:Antigen-Antibody Complex; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D055088:Early Detection of Cancer; D005947:Glucose / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D009369:Neoplasms / Q000175:diagnosis*; D019095:Point-of-Care Systems; D013395:Sucrose / Q000378:metabolism; D043324:beta-Fructofuranosidase / Q000378:metabolism
D000936:Antigen-Antibody Complex; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D013395:Sucrose; D043324:beta-Fructofuranosidase; D005947:Glucose