Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential.
The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol-gel chemical route; these compounds possess flexible Si-O-Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.
Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Shi-qiang
SQ
Gong
Li-Na
LN
Niu
Lisa K
LK
Kemp
Cynthia K Y
CK
Yiu
Heonjune
H
Ryou
Yi-Pin
YP
Qi
John D
JD
Blizzard
Sergey
S
Nikonov
Martha G
MG
Brackett
Regina L W
RL
Messer
Christine D
CD
Wu
Jing
J
Mao
L
L
Bryan Brister
Frederick A
FA
Rueggeberg
Dwayne D
DD
Arola
David H
DH
Pashley
Franklin R
FR
Tay
D000190:Actinomyces / Q000187:drug effects; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005434:Flow Cytometry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013295:Streptococcus mutans / Q000187:drug effects; D013818:Thermogravimetry
D000890:Anti-Infective Agents; D008689:Methacrylates; D000644:Quaternary Ammonium Compounds; D012821:Silanes