Surgical management of early-stage non-small cell lung carcinoma and the present and future roles of adjuvant therapy: a review for the radiation oncologist.
We review the evidence for optimal surgical management and adjuvant therapy for patients with stages I and II non-small cell lung cancer (NSCLC) along with factors associated with increased risks of recurrence. Based on the current evidence, we recommend optimal use of mediastinal lymph node dissection, adjuvant chemotherapy, and post-operative radiation therapy, and make suggestions for areas to explore in future prospective randomized clinical trials.
Department of Emergency Medicine, Ben Taub General Hospital, Houston, TX, USA.
Laura
L
Medford-Davis
Malcom
M
Decamp
Abram
A
Recht
John
J
Flickinger
Chandra P
CP
Belani
John
J
Varlotto
D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods / Q000401:mortality / Q000639:trends; D055088:Early Detection of Cancer; D005544:Forecasting; D006801:Humans; D008168:Lung / Q000601:surgery*; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008197:Lymph Node Excision / Q000379:methods / Q000401:mortality; D008207:Lymphatic Metastasis; D008482:Mediastinum; D020360:Neoadjuvant Therapy / Q000379:methods / Q000401:mortality / Q000639:trends; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011013:Pneumonectomy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D017410:Practice Guidelines as Topic; D018787:Radiation Oncology; D018714:Radiotherapy, Adjuvant / Q000379:methods / Q000401:mortality / Q000639:trends; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D047368:Tumor Burden