[The natural story of tuberculosis].
Tuberculosis is one of the infectious diseases that had a huge impact on the health of the populations since the XVIIth century, and this remains true for most of the people in the World in 2012. Its natural story involves: contamination (inhalation of infectious particles, the Pflügge droplets, originating from a patient with bacillary tuberculosis); primary infection (remarkable by initial unresponsiveness of the immune system, followed by strong cellular immunity development within 3 to 9 weeks); latent tuberculosis infection, non-contagious and totally asymptomatic, with efficient control of tuberculosis bacilli replication, lasting for life in more than 90% of cases; and less frequently, tuberculosis disease in patients with insufficient immunity, including children less than 5 years, immunocompromised, and patients recently infected.
Maladies infectieuses et réanimation médicale, CHU Pontchaillou.
Hélène
H
Leroy
Matthieu
M
Revest
Pierre
P
Tattevin
D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D055985:Latent Tuberculosis / Q000000981:diagnostic imaging / Q000276:immunology; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011859:Radiography; D014376:Tuberculosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology / Q000635:transmission*