Measurements of lenticulostriate arteries using 7T MRI: new imaging markers for subcortical vascular dementia.
Recent studies have demonstrated that ultra-high resolution MRA imaging using 7 Tessla (T) MRI can be employed to noninvasively visualize the lenticulostriate arteries (LSA) that supply the basal ganglia and internal capsule. Subcortical vascular dementia (SVaD) is believed to involve these regions from an early stage. We investigated whether LSA abnormalities measured by 7T MRA correlate with MRI ischemia markers and neuropsychological/motor deficits. A total of 24 subjects (12 with SVaD, 12 normal controls (NC)) were imaged with 3T and 7T MRIs. We assessed the severity of white matter hyperintensities (WMH) and the number of lacunes and microbleeds (MB) by visually inspecting images obtained from conventional 3T MRI. We also analyzed three-dimensional models of the measured LSAs obtained from 7T MRI. Compared to the NC, the SVaD subjects had fewer branches of LSAs and greater radii of LSAs. The number of branches was correlated with the number of lacunes. The number of branches was correlated with the delayed recall scores on Rey's Complex Figure Test (RCFT). While not quite reaching statistical significance, the immediate recall, recognition scores on the RCFT, recognition scores on the Seoul Verbal Learning Test, and the word and color readings of Stroop trended in the direction of correlation with the number of branches, as well as with the extrapyramidal scores. Our findings suggest that LSA imaging using 7T MRI might be a potent candidate for the detection of SVaD.
Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
Sang Won
SW
Seo
Chang-Ki
CK
Kang
Sook Hui
SH
Kim
Doo Sang
DS
Yoon
Wei
W
Liao
Stefan
S
Wörz
Karl
K
Rohr
Young-Bo
YB
Kim
Duk L
DL
Na
Zang-Hee
ZH
Cho
D000368:Aged; D001479:Basal Ganglia / Q000098:blood supply* / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology*; D015140:Dementia, Vascular / Q000175:diagnosis*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales