Hydrogen therapy may be an effective and specific novel treatment for aplastic anemia.
Aplastic anemia (AA) is a rare bone marrow failure disorder with high mortality rate, which is characterized by pancytopenia and an associated increase in the risk of hemorrhage, infection, organ dysfunction and death. The oxidation phenomenon and/or the formation of free radicals have been suggested to be causally related to various hematological disorders, including aplastic anemia. TNF-α, IL-6, and IL-2 also play important roles in the pathogenesis of AA. Recent studies have provided evidence that hydrogen inhalation can selectively reduce cytotoxic oxygen radicals and exert antioxidant effects. It was also reported that hydrogen could suppress the levels of TNF-α and IL-6. Based on these findings, we hypothesize that hydrogen therapy may be an effective, simple, economic and novel strategy in the treatment of aplastic anemia.
Department of Haematology, Naval General Hospital, Fucheng Road, Beijing, P.R. China. qlr2007@126.com
Liren
L
Qian
Jianliang
J
Shen
Jianming
J
Cai
D000741:Anemia, Aplastic / Q000188:drug therapy*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006859:Hydrogen / Q000008:administration & dosage / Q000627:therapeutic use*; D008954:Models, Biological
D005609:Free Radicals; D006859:Hydrogen