The aging perioral region -- Do we really know what is happening?
OBJECTIVE
The perioral region is subject to a myriad of different treatments for rejuvenation, many of which are applied without a clear understanding of the underlying physiological processes of perioral aging. The results of these procedures are therefore sometimes not optimal and do not achieve a natural youthful appearance. The aim of this study was to put the results of three investigations into the perioral aging process into relation to clinical application in aesthetic medicine.


METHODS
Three different investigations were performed to evaluate the complex 3-dimensional changes during the perioral aging process. Perioral proportions of 182 standardized subject photographs were measured in a photomorphometric study and correlated to age. In cranial MRI scans of 30 women aged 20-35 and 30 women aged 65-80 relevant anatomical dimensions were measured. Histological cross cuts of the upper lip complex of 20 individuals in two age groups, young (< 40 years, n = 10) and old (> 80 years, n = 10), were analysed. The results were then set into relation to today's lip rejuvenation procedures.


RESULTS
All studies showed a statistically significant lengthening of the aging upper lip. The photomorphometric study further showed an increase of prolabium skin at the cost of a decreasing visible upper lip vermilion. The MRI scans showed a decrease in thickness and redistribution towards a length increase but no total volume loss. Histomorphometric analysis revealed statistically significant thinning of the cutis, thickening of the subcutis and a degeneration of elastic and collagen fibers. The orbicularis oris muscle becomes thinner and shows a decrease of the forward curve defining the vermilion border. The results show that the main processes of lip aging are redistribution from thickness to length without total volume loss and a decrease of structural components of the lip, which leads to the decrease of pouting, an inversion of the vermilion and a ptosis of the lip.


CONCLUSIONS
A new and better understanding of the underlying physiological changes of perioral aging is essential and will lead to a better and more specific implementation of perioral rejuvenation procedures which will lead to more natural results.
Department of Plastic and Hand Surgery, University Medical Center Freiburg, Freiburg, Germany. niklas.iblher@uniklinik-freiburg.de
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Iblher
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Stark
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Penna
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D005145:Face / Q000033:anatomy & histology*; D005152:Facial Muscles / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008046:Lip / Q000033:anatomy & histology / Q000166:cytology; D008297:Male; D009055:Mouth / Q000033:anatomy & histology; D010781:Photography; D010858:Pigmentation; D015595:Skin Aging; D040521:Subcutaneous Tissue / Q000033:anatomy & histology; D055815:Young Adult