Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs.
OBJECTIVE
This study was designed to evaluate the potential adjunctive benefits of platelet-rich plasma (PRP) when used with guided-tissue regeneration (GTR) and bioactive glass (BG) in the treatment of Class II furcation lesions.


METHODS
Bilateral Class II furcation lesions were surgically created and allowed to become chronic in the mandibular third premolars of 9 dogs. The defects were randomly assigned to: A) GTR+BG and B) GTR+BG+PRP. Similar defects were created in the maxillary third premolars and received the same treatments after 45 days. Dogs were sacrificed 90 days after the first treatment. The histometric parameters evaluated were: connective tissue adaptation, new cementum, new bone, mineralized bone area, non-mineralized bone area, and residual BG particle area.


RESULTS
Data analysis showed a superior length of new cementum and a greater mineralized bone area for group B in both periods (p<0.05). The non-mineralized bone area was greater in the control group (p<0.05) in both periods.


CONCLUSIONS
Within the limits of this study, it can be concluded that the use of PRP in the treatment of Class II furcation defects may enhance the amount of new cementum and provide a more mineralized bone in a shorter period of time.
Department of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil.
Fabrícia Ferreira
FF
Suaid
Marcelo Diniz
MD
Carvalho
Gláucia Maria Bovi
GM
Ambrosano
Francisco Humberto
FH
Nociti
Marcio Zaffalon
MZ
Casati
Enilson Antônio
EA
Sallum
D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D002516:Ceramics / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D023421:Models, Animal; D010510:Periodontal Diseases / Q000601:surgery; D053657:Platelet-Rich Plasma; D011897:Random Allocation; D013997:Time Factors; D014945:Wound Healing
C022107:Bioglass; D018786:Bone Substitutes