Logic circuit upon angiogenic response controlled by enzyme-linked iron oxide microparticles--towards biocomputing in human cells.
In the present study, we designed a logic circuit upon angiogenic response controlled by a combination of enzyme-functionalized magnetic microparticles operating in human umbilical vein endothelial cells (HUVECs). The reported results represent the first example of a biocomputing system operating in controlling angiogenesis.
Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea.
Kyung-Woo
KW
Kim
Yang Eon
YE
Kim
Vera
V
Bocharova
Jan
J
Halámek
Chang-Woo
CW
Lee
Evgeny
E
Katz
Min-Kyu
MK
Oh
D000465:Algorithms; D002374:Catalase / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008280:Magnetics; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D004798:Enzymes; D005290:Ferric Compounds; D042461:Vascular Endothelial Growth Factor A; C000499:ferric oxide; D006861:Hydrogen Peroxide; D005949:Glucose Oxidase; D002374:Catalase