Multianalyte digital enzyme biosensors with built-in Boolean logic.
Novel biosensors based on the biocomputing concept digitally process multiple biochemical signals through Boolean logic networks of coupled biomolecular reactions and produce output in the form of a YES/NO response. Compared to traditional single-analyte sensing devices, biocomputing approach enables a high-fidelity multianalyte biosensing, particularly beneficial for biomedical applications.
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13699, United States. ekatz@clarkson.edu
Evgeny
E
Katz
Joseph
J
Wang
Marina
M
Privman
Jan
J
Halámek
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D055162:Biocatalysis; D015374:Biosensing Techniques / Q000295:instrumentation*; D039301:Computers, Molecular; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000293:injuries / Q000378:metabolism; D009243:NAD / Q000032:analysis / Q000378:metabolism; D012815:Signal Processing, Computer-Assisted; D013552:Swine
D009243:NAD; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase