[A new model of depression induced by psychogenenic stress].
A new depression model has been obtained, based on use of stressors of the psychogenic nature. The laboratory rats in a special stress-camera turned out to be unable to induce the bilateral reaction of active avoidance, with subsequently led to formation of depression in the animals. Analysis of the tests sensitive to depression--a forceful swimming and a hanging by tail as well as of dynamics of the animals' body mass and of the behavior on the whole confirms development of their depression. This model has turned out to be sensitive to a selective inhibitor of the serotonin reuptake--fluoxetine; this also indicates our obtained model to be a model of depression.
K N
KN
Chichinadze
T R
TR
Domianidze
T Ts
TTs
Matitashvili
I D
ID
Labadze
I N
IN
Pantculaia
M M
MM
Chananashvili
D000818:Animals; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological; D013550:Swimming
D005473:Fluoxetine