Small dense LDL: risk factor for coronary artery disease (CAD) and its therapeutic modulation.
Pathogenesis of coronary artery disease (CAD) is multi-factorial and many risk factors are associated with development of CAD. LDL-C has been an important target for therapeutic interventions and has been extensively studied. But, various studies have indicated that estimation of LDL-C is not enough to assess the risk. Moreover, LDL particles vary in their content, density and size which have different physico-chemical properties. In this paper, the role of small dense (sd) LDL in risk assessment for CAD and its response to different therapeutic modalities available have been reviewed.
Department of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi 110095, India. drsbs08@hotmail.com
Suman B
SB
Sharma
Seema
S
Garg
D050197:Atherosclerosis / Q000150:complications; D008078:Cholesterol, LDL / Q000097:blood / Q000737:chemistry* / Q000378:metabolism*; D019963:Clinical Chemistry Tests; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D012307:Risk Factors
D008078:Cholesterol, LDL