Posttransplant lymphoproliferative disorder presenting as a nonhealing extraction socket: a case report and review of the literature.
Posttransplant lymphoproliferative disorder (PTLD) is a well-recognized complication of long-term immunosuppression following hematopoietic or solid organ transplantation and is associated with significant morbidity and mortality. We present a unique case of PTLD that manifested with a nonhealing dental extraction socket 17 years after renal transplantation. We summarize the existing literature and present a review of an additional 25 cases. These highlight the variable clinical presentations of PTLD within the oral cavity and clear potential for delayed presentation at this anatomical subsite.
Bristol Dental Hospital, UK. holly.cole-hawkins@bristol.ac.uk
Holly
H
Cole-Hawkins
Eithne
E
Fyfe
Chris
C
Price
Miranda
M
Pring
D000284:Administration, Oral; D019386:Alendronate / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D008963:Molar / Q000601:surgery; D000069283:Rituximab; D014081:Tooth Extraction / Q000009:adverse effects*; D020390:Tooth Socket / Q000473:pathology*
D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D050071:Bone Density Conservation Agents; D000069283:Rituximab; D019386:Alendronate