Correlation between instrumental activities of daily living and white matter hyperintensities in amnestic mild cognitive impairment: results of a cross-sectional study.
Although some studies have supported the association between white matter hyperintensities (WMH) and cognitive impairment, whether WMH are associated with the impairments in instrumental activities of daily living (IADLs) remains unknown. This cross-sectional study investigated differences in basic ADLs and IADLs among different severity of WMH in a large, well-defined registry of patients with amnestic mild cognitive impairment (aMCI). 1,514 patients with aMCI were divided into three groups according to the degree of WMH (1,026 mild, 393 moderate, and 95 severe). We compared the total IADL scores and analyzed the prevalence of the impairment for each IADL item for each group. The severity of WMH was associated with the impairments in IADLs. Among 15 Seoul IADL items, "using public transportation", "going out (short distance)", "grooming" and "participating in leisure activities/hobbies" showed greater positive association with the severity of WMH. WMH in patients with aMCI were associated with the impairments in IADLs but not in basic ADLs. These findings are likely to be more obvious with respect to using public transportation, going out (short distances), shopping, grooming and participating in leisure activities/hobbies.
Department of Neurology, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Republic of Korea.
Bora
B
Yoon
Yong S
YS
Shim
Yong-Duk
YD
Kim
Kee Ook
KO
Lee
Sang-Jun
SJ
Na
Yun-Jeong
YJ
Hong
Yoon-Sang
YS
Oh
Duk L
DL
Na
Sang Won
SW
Seo
Kyung Won
KW
Park
So Young
SY
Moon
Sang Yun
SY
Kim
Jae-Hong
JH
Lee
Seong Hye
SH
Choi
Dong-Won
DW
Yang
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000150:complications / Q000473:pathology / Q000523:psychology; D001921:Brain / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000150:complications / Q000473:pathology / Q000523:psychology; D003216:Conditioning, Operant / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D016017:Odds Ratio; D056910:Republic of Korea; D012189:Retrospective Studies