Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
As a part of an ongoing search for novel antioxidants from the salt marsh plants, bioactivity-isolation and structure determination of constituents from Salicornia herbacea were performed. One new triterpenoid saponin (4), along with three known saponins (1-3), has been isolated from n-BuOH fraction of S. herbacea. On the basis of the spectroscopic methods, the structure of the new saponin 4 was elucidated as 3β-hydroxy-23-oxo-30-noroleana-12, 20(29)-diene-28-oic acid 3-O-β-D-glucuronopyranosyl-28-O-β-d-glucopyranoside. Scavenging effects of saponins 1-4 were examined on 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical and peroxynitrite. Particularly, saponin 3 exerted significant antioxidant activity on both authentic peroxynitrite and peroxynitrite generated from morpholinosydnonimine (SIN-1).
Natural Compounds Bank Establishment Department, Korea Promotion Institute for Traditional Medicine Industry, Gyeongbuk 712-260, Republic of Korea.
You Ah
YA
Kim
Chang-Suk
CS
Kong
Jung Im
JI
Lee
Hojun
H
Kim
Hee Yeon
HY
Park
Hyi-Seung
HS
Lee
Chulhyun
C
Lee
Youngwan
Y
Seo
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D019663:Chenopodiaceae / Q000737:chemistry*; D008968:Molecular Conformation; D008981:Molsidomine / Q000031:analogs & derivatives / Q000737:chemistry; D030421:Peroxynitrous Acid / Q000737:chemistry; D055051:Salt-Tolerant Plants / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry*
C575693:3-hydroxy-23-oxo-30-noroleana-12,20(29)-diene-28-oic acid 3-O-glucuronopyranosyl-28-O-glucopyranoside; D000975:Antioxidants; D012503:Saponins; D014315:Triterpenes; D030421:Peroxynitrous Acid; C002385:linsidomine; D008981:Molsidomine