Apoptosis of peripheral blood lymphocytes and mutations in the gene of the T-cell receptor in survivors of chronic radiation exposure.
This research has been conducted to study the activity of apoptosis of peripheral blood lymphocytes (PBLs) and the frequency of CD3-/CD4+ PBLs in people who have suffered chronic low-intensity radiation exposure. An increase in the frequency of apoptotic cells (TUNEL) is demonstrated in the group of exposed individuals relative to the control group. The frequency of mutations in the gene of the T-cell receptor in the exposed individuals is also elevated. Analyses of the mean values of apoptosis and CD3-CD4+ PBLs in different dose subgroups have found an increase in the proportion of cells with mutant T-cell receptors against the background of a decrease in the frequency of apoptotic cells in the range of low and medium radiation doses.
Urals Research Center for Radiation Medicine, 68-A Vorovsky Street, Chelyabinsk, 454076, Russia. daff_84@mail.ru
Evgenia A
EA
Blinova
Galina A
GA
Veremeyeva
Alexander V
AV
Akleyev
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000528:radiation effects*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D017741:Survivors; D013997:Time Factors
D011948:Receptors, Antigen, T-Cell