PSA Response to Lenalidomide Therapy in a Pre-Treated Patient with Metastatic Prostate Cancer Refractory to Hormones and Chemotherapy: A Case Report.
Hormone-resistant prostate cancer (HRPC) occurs when prostate cancer is no longer responsive to hormone therapy. Treatment options are limited, and there is a clear necessity for therapies that improve outcome. Preclinical and clinical evidence supports the role of the immunomodulatory agent lenalidomide in HRPC. In this paper, we report that lenalidomide showed antitumoral activity in a patient with HRPC and bone metastases pre-treated with chemotherapy, decreased the PSA level and improved the patient's health status for the first 5 months. It is important to emphasize that it was not associated with hematologic toxicity.
Departamento de Oncología Médica y, Universidad de Alicante, Alicante, y, Valéncia, España.
Joan Manel
JM
Gasent Blesa
Miguel Peris
MP
Godoy
María Fonfría
MF
Esparcia
Sara Blasco
SB
Mollá
Balbino Mancheño
BM
Magán
José Miguel
JM
Sempere Ortells
José Luis
JL
Sánchez