Role of cockroach proteases in allergic disease.
Allergic asthma is on the rise in developed countries, and cockroach exposure is a major risk factor for the development of asthma. In recent years, a number of studies have investigated the importance of allergen-associated proteases in modulating allergic airway inflammation. Many of the studies have suggested the importance of allergen-associated proteases as having a direct role on airway epithelial cells and dendritic cells. In most cases, activation of the protease activated receptor (PAR)-2 has been implicated as a mechanism behind the potent allergenicity associated with cockroaches. In this review, we focus on recent evidence linking cockroach proteases to activation of a variety of cells important in allergic airway inflammation and the role of PAR-2 in this process. We will highlight recent data exploring the potential mechanisms involved in the biological effects of the allergen.
Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave ML7006, Cincinnati, OH, USA. Kristen.page@cchmc.org
Kristen
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D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000209:etiology; D003058:Cockroaches / Q000201:enzymology*; D006801:Humans; D006967:Hypersensitivity / Q000201:enzymology / Q000209:etiology* / Q000276:immunology; D007113:Immunity, Innate; D007114:Immunization / Q000009:adverse effects; D010447:Peptide Hydrolases / Q000187:drug effects / Q000276:immunology*; D044464:Receptor, PAR-2 / Q000378:metabolism; D012137:Respiratory System / Q000276:immunology*; D053481:Secretory Leukocyte Peptidase Inhibitor / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D000485:Allergens; D044464:Receptor, PAR-2; C043392:SERPINA1 protein, human; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor; D000515:alpha 1-Antitrypsin; D010447:Peptide Hydrolases