The total synthesis of (-)-aurafuron A.
The first total synthesis of (-)-aurafuron A is presented. It features a Suzuki cross-coupling reaction and a high yielding anionic aldol addition as central carbon skeleton building reactions. The synthesis confirms the proposed structure including its configuration and allows for detailed SAR studies.
Institut für Organische Chemie and Centre of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
Olaf
O
Hartmann
Markus
M
Kalesse
D005663:Furans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D005663:Furans; C502099:aurafuron A