[Cell technologies and the development of skin substitutes].
Large skin lesions might be of different cause and sometime resistant to the conventional and surgical treatment. For many years, skin grafting used to serve one of the most important methods to treat large and deep skin lesions. However, a limited availability of the substrate for transplantation restricts wider application of the approach. Utilization of wound covers and skin replacements of various types (including synthetic, biological and biosynthetic ones) provides an alternative. Skin substitutes--biosynthetic covers of the complex structure--constitute the most important niche in a wide spectrum of wound covers developed and actively utilized by today. Cell substrates used in the former include dermal fibroblasts, neonatal foreskin fibroblasts and keratinocytes. In the current review, key properties of the modern skin substitutes, structure features of the most widespread types. and principle of the work with the particular cell types are analyzed. Comparative analysis of the efficiency of wound covers is provided.
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Anisimov
D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology* / Q000637:transplantation; D052816:Foreskin / Q000166:cytology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000637:transplantation; D008297:Male; D012867:Skin / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D016038:Skin Transplantation; D017768:Skin, Artificial; D013526:Surgical Mesh; D023822:Tissue Engineering / Q000379:methods*; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials; D003094:Collagen