Oxidized low-density lipoproteins and their antibodies: relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases.
BACKGROUND
Metabolic predictors and the atherogenicity of oxidized LDL (oxLDL) and the specific antibodies against oxLDL (oxLDL Ab) are unclear and controversial.


METHODS
In 107 adults without atherosclerotic manifestations, we measured oxLDL and oxLDL Ab, and also the activities of CETP, PLTP, lipases and the carotid intima-media thickness (cIMT). Comparisons were performed for the studied parameters between the lowest and the highest tertile of oxLDL and oxLDL Ab, and the relationships between studied variables were evaluated.


RESULTS
Subjects with higher oxLDL Ab present reduced hepatic lipase activity and borderline increased cIMT. In the highest oxLDL tertile, besides the higher levels of total cholesterol, LDL-C and apoB100, we found reduced CETP activity and higher cIMT. A significant correlation between oxLDL Ab and cIMT, independent of oxLDL, and a borderline correlation between oxLDL and cIMT independent of oxLDL Ab were found. In the multivariate analysis, apoAI was a significant predictor of oxLDL Ab, in contrast to regulation of oxLDL by apoB100, PLTP and inverse of CETP.


CONCLUSIONS
In adults without atherosclerotic disease, the metabolic regulation and carotid atherosclerosis of oxLDL Ab and oxLDL groups, characterized a dual trait in oxLDL Ab, as a contributor to carotid atherosclerosis, much less so than oxidized LDL, and with a modest atheroprotective role.
School of Medical Sciences, Department of Clinical Pathology and Center for Medicine and Experimental Surgery-NMCE, University of Campinas-UNICAMP, São Paulo, Brazil.
Paolla F C
PF
Ferreira
Vanessa H S
VH
Zago
Fabio L
FL
D'Alexandri
Natália B
NB
Panzoldo
Magnus A
MA
Gidlund
Rui T
RT
Nakamura
Roberto
R
Schreiber
Eliane S
ES
Parra
Fernanda D
FD
Santiago
Edna R
ER
Nakandakare
Eder C R
EC
Quintão
Eliana C
EC
de Faria
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000906:Antibodies / Q000097:blood*; D053299:Apolipoprotein B-100 / Q000097:blood; D001692:Biological Transport; D002339:Carotid Arteries / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000097:blood* / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D049294:Phospholipid Transfer Proteins / Q000378:metabolism; D012307:Risk Factors
D000906:Antibodies; D053299:Apolipoprotein B-100; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; C504173:LIPC protein, human; D008077:Lipoproteins, LDL; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins; C099252:oxidized low density lipoprotein; D002784:Cholesterol; D008049:Lipase