Glutathione s-transferases in pediatric cancer.
The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs. The associations between GST polymorphisms/functions and human disease susceptibility or treatment outcome, mostly in adults, have been extensively studied and reviewed. This mini review focuses on studies related to GST epidemiology and functions related to pediatric cancer. Opportunities to exploit GST in pediatric cancer therapy are also discussed.
The Department of Oncological Sciences, University of Utah School of Medicine Salt Lake City, UT, USA.
Wen
W
Luo
Michelle
M
Kinsey
Joshua D
JD
Schiffman
Stephen L
SL
Lessnick