A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway.
TNF-related weak inducer of apoptosis (TWEAK) is a new member of the TNF superfamily. It signals through TNFRSF12A, commonly known as Fn14. The TWEAK-Fn14 interaction regulates cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, tissue remodeling and inflammation. Although TWEAK has been reported to be associated with autoimmune diseases, cancers, stroke, and kidney-related disorders, the downstream molecular events of TWEAK-Fn14 signaling are yet not available in any signaling pathway repository. In this paper, we manually compiled from the literature, in particular those reported in human systems, the downstream reactions stimulated by TWEAK-Fn14 interactions. Our manual amassment of the TWEAK-Fn14 pathway has resulted in cataloging of 46 proteins involved in various biochemical reactions and TWEAK-Fn14 induced expression of 28 genes. We have enabled the availability of data in various standard exchange formats from NetPath, a repository for signaling pathways. We believe that this composite molecular interaction pathway will enable identification of new signaling components in TWEAK signaling pathway. This in turn may lead to the identification of potential therapeutic targets in TWEAK-associated disorders.
Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Mitali
M
Bhattacharjee
Rajesh
R
Raju
Aneesha
A
Radhakrishnan
Vishalakshi
V
Nanjappa
Babylakshmi
B
Muthusamy
Kamlendra
K
Singh
Dheebika
D
Kuppusamy
Bhavya Teja
BT
Lingala
Archana
A
Pan
Premendu Prakash
PP
Mathur
H C
HC
Harsha
T S Keshava
TS
Prasad
Gerald J
GJ
Atkins
Akhilesh
A
Pandey
Aditi
A
Chatterjee