Pd-catalyzed cross-coupling of aryl carboxylic acids with propiophenones through a combination of decarboxylation and dehydrogenation.
A Heck of a reaction: With a PCy(3)-supported Pd catalyst, aryl carboxylic acids cross-couple to saturated propiophenones through a combination of decarboxylation and dehydrogenation to give chalcones bearing a variety of functional groups in generally good yields (see scheme). Furthermore, a one-pot procedure, involving this reaction and a subsequent selective hydrogenative cyclization process, has been developed for the facile synthesis of quinoline derivatives from 2-nitrobenzoic acids.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao west road 155#, Fuzhou, Fujian 350002, PR China.
Jun
J
Zhou
Ge
G
Wu
Min
M
Zhang
Xiaoming
X
Jie
Weiping
W
Su