Access to C(sp3)-C(sp2) and C(sp2)-C(sp2) bond formation via sequential intermolecular carbopalladation of multiple carbon-carbon bonds.
A synthetic strategy of 4-benzyl-substituted 1,3-butadiene derivatives through Pd-catalyzed three-component coupling reaction of benzyl chlorides, alkynes, and monosubstituted alkenes is described. This tandem coupling reaction forms a C(sp(3))-C(sp(2)) bond and a C(sp(2))-C(sp(2)) bond sequentially in a single-step operation.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Yanmei
Y
Wen
Liangbin
L
Huang
Huanfeng
H
Jiang