Very small photoluminescent gold nanoparticles for multimodality biomedical imaging.
An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.
Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 640, Taiwan.
Sheng-Feng
SF
Lai
Chia-Chi
CC
Chien
Wen-Chang
WC
Chen
Hsiang-Hsin
HH
Chen
Yi-Yun
YY
Chen
Cheng-Liang
CL
Wang
Y
Y
Hwu
C S
CS
Yang
C Y
CY
Chen
K S
KS
Liang
Cyril
C
Petibois
Hui-Ru
HR
Tan
Eng-Soon
ES
Tok
G
G
Margaritondo
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005227:Fatty Acids; D006046:Gold; D006801:Humans; D008027:Light; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000648:ultrastructure*; D051379:Mice; D008807:Mice, Inbred BALB C; D008853:Microscopy / Q000379:methods; D046529:Microscopy, Electron, Transmission; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000473:pathology; D017550:Spectroscopy, Fourier Transform Infrared; D013438:Sulfhydryl Compounds; D013818:Thermogravimetry; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D014965:X-Rays
C505222:11-mercaptoundecanoic acid; D005227:Fatty Acids; D013438:Sulfhydryl Compounds; D006046:Gold