Aortic flow propagation velocity as an early predictor of high coronary risk in hypertensive patients.
OBJECTIVE
To assess the value of aortic flow propagation velocity (Vp) in detecting hypertensive patients with coronary risk.


METHODS
The study included 120 patients with hypertension. According to the 10-year risk of coronary heart disease the patients were categorized in the three groups: 10-year risk  < 10% (I),10 - year risk=%10 - 20 (II), and 10-year risk > 20% (III). The aortic flow propagation velocity (Vp) was measured from descending aorta with color M-mode echoardiography. The slope of the first aliasing contour was accepted as Vp. It was compared with Framingham coronary risk score, carotid intima media thickness and high sensitive C-reactive protein. Twelve patients were excluded from the study due to poor acoustic window.


RESULTS
The Vp was significantly lower (p<0.001), carotid intima media thickness and high sensitive C-reactive protein was significantly higher in group III (p=0.002 and p=0.014). The area under ROC curve of Vp, carotid intima media thickness and high sensitive C-reactive protein were 0.890, 0,700 and 0.664, respectively. There was a significant inverse relation between Vp and carotid intima media thickness (r=-0.37; p<0.001).


CONCLUSIONS
The aortic flow propagation velocity is a simple, feasible and reproducible marker of atherosoclerosis with an acceptable sensitivity and specificity. There is a need for longitudinal prospective studies to use it routinely.
Department of Cardiology, Gulhane Military Medical School, Etlik, Ankara, Turkey.
Mustafa
M
Yıldırım
Omer
O
Yiginer
Mehmet
M
Uzun
Bekir
B
Yilmaz Cingozbay
Cemal
C
Sag
Hasan
H
Kutsi Kabul
Omer
O
Uz
Zafer
Z
Isilak
Ejder
E
Kardesoglu
Bekir
B
Sitki Cebeci
D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001783:Blood Flow Velocity; D059168:Carotid Intima-Media Thickness; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity