Lipids and all-cause mortality among older adults: a 12-year follow-up study.
This is a 12-year follow-up cohort study with 800 people (60-85 years old). The association between lipid disorders and mortality was analysed by Cox proportional hazard adjusted model. All-cause mortality was considered the dependent variable, and lipid disorders as independent variables: total cholesterol (TC) >200 and <170 mg/dl, HDL-c <35 and 40, LDL-c >100 and 130, and triglycerides (TG) >50. An initial analysis of all subjects was performed and a second was carried out after having excluded individuals with a body mass index (BMI) <20 kg/m² or mortality in ≤ 2 years. The mortality showed a positive association with low TC and a negative association with high TC and high LDL-c. After the exclusion of underweight and premature mortality, there was a positive association only with TC <170 mg/dl (HR = 1.36, CI95%: 1.02-1.82). The data did not show a higher risk with high levels of TC, LDL-c, and TG. However, they showed higher mortality among older adults with low TC.
Postgraduate Program in Public Health, State University of Londrina-UEL, Robert Koch Avenue, 60 CEP, 86038440 Londrina, PR, Brazil. marcoscabrera@uol.com.br
Marcos Aparecido Sarria
MA
Cabrera
Selma Maffei
SM
de Andrade
Renata Maciulis
RM
Dip
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D009026:Mortality