Stent thrombosis: an overview.
Stent thrombosis is a challenging problem following percutaneous coronary intervention that can lead to serious clinical consequences, such as death and acute myocardial infarction. Its pathophysiology is not yet completely known, and there are several causes suggested, such as incomplete stent endothelization, presence of polymers and late incomplete stent apposition. One of the main predictors is the early discontinuation of dual antiplatelet therapy. Stent improvements related to their design, with more friendly metallic platforms, thinner biocompatible or biodegradable polymers, absence of polymers, and even stents manufactured with bioabsorbable materials, could make the percutaneous procedure much safer and effective, allowing its application in increasingly complex anatomic and clinical scenarios, with low thrombosis rates.
Instituto Dante Pazzanese of Cardiologia, 500 Dante Pazzanese Avenue, Sao Paulo, Brazil. mpcentemero@yahoo.com.br
Marinella Patrizia
MP
Centemero
Jackson Rafael
JR
Stadler
D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D000818:Animals; D004359:Drug Therapy, Combination; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011474:Prosthesis Design; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control
D010975:Platelet Aggregation Inhibitors