Risk factor analysis of vasovagal reaction from blood donation.
BACKGROUND
Vasovagal reaction (VVR) is the most frequent side effect at blood collection sites.


OBJECTIVE
To protect donors, factors contributing to VVR were analysed.


METHODS
Complications following whole blood and apheresis donations have been recorded and accumulated by the Japanese Red Cross Tokyo Blood Centre. A dataset of 43,948 donors who had no complications was prepared as a control by randomly selecting days in each season in the 2006 and 2007 fiscal years. Factors contributing to 4924 VVR incidents in the 2006 and 2007 fiscal years were analysed by univariate and multivariate logistic regression.


RESULTS
The age, weight, body mass index (BMI), predonation systolic and diastolic pressure, and circulating blood volume were lower, and the pulse was higher, for the VVR group compared to the control group (p<0.0001). The VVR group had more female donors, less sleep, and more time since a meal than the control. In multivariate analysis, significant risk factors for 400 ml whole blood donors, which are the majority of donors, were an age <50 years, being female, a BMI <25, pulse ≥90/min, sleep duration <8 h, the time after eating ≥4 h, a first time donation and circulating blood volume of <4.3 l. Sleep duration of <6 h was shown to be a VVR risk as much as a first time donation.


CONCLUSIONS
From our analysis, the amount of sleep obtained the previous night should be considered at the reception of donors.
Japanese Red Cross Tokyo Blood Centre, Tokyo 135-8639, Japan. mi-takanashi@tokyo.bc.jrc.or.jp
Minoko
M
Takanashi
Takeshi
T
Odajima
Seiko
S
Aota
Mitsuaki
M
Sudoh
Yoshio
Y
Yamaga
Yuriko
Y
Ono
Kentaro
K
Yoshinaga
Toshiko
T
Motoji
Koji
K
Matsuzaki
Masahiro
M
Satake
Hiroki
H
Sugimori
Kazunori
K
Nakajima
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D019462:Syncope, Vasovagal / Q000209:etiology*; D055815:Young Adult