Non-cancerous prognostic factors of hepatocellular carcinoma after liver transplantation.
OBJECTIVE
To explore non-cancerous factors that may be related with medium-term survival (24 months) after liver transplantation (LT) in this data from northeast Brazil.


METHODS
A cross-sectional study was carried out in patients who underwent deceased-donor orthotopic LT because hepatocellular carcinoma (HCC) at the University of Pernambuco, Brazil. Non-cancerous factors (i.e.: donor-, receptor-, surgery- and center-related variables) were explored as prognostic factors of medium-term survival using univariate and multivariate approachs.


RESULTS
Sixty-one patients were included for analysis. Their three, six, 12 and 24-month overall cumulative survivals were 88.5%, 80.3%, 73.8% and 65.6%, respectively. Our univariate analysis identified red blood cell transfusion (Exp[b]=1.26; p<0.01) and hepato-venous reconstruction technique (84.6% vs. 51.4%, p<0.01; respectively for piggyback and conventional approaches) as significantly related to post-LT survival. The multivariate analysis confirmed the hepato-venous reconstruction technique was an independent prognostic factor.


CONCLUSIONS
The piggyback technique was related to improved medium-term survival of hepatocellular carcinoma patients after liver transplantation in this northeast Brazilian sample.
UPE, Pernambuco, Brazil. t.paulo@bol.com.br
Thales Paulo
TP
Batista
Luiz Eduardo Correia
LE
Miranda
Bernardo David
BD
Sabat
Paulo Sérgio Vieira de
PS
Melo
Olival Cirilo Lucena da
OC
Fonseca Neto
Américo Gusmão
AG
Amorim
Cláudio Moura
CM
Lacerda
D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome