Cardiac changes in horses with atypical myopathy.
BACKGROUND
Atypical myopathy (AM) is an acute, fatal rhabdomyolysis in grazing horses that mainly affects skeletal muscles. Postmortem examinations have shown that myocardial damage also occurs. Limited information is available on the effect of AM on cardiac function in affected and surviving horses.


OBJECTIVE
To describe electrocardiographic and echocardiographic changes associated with AM in the acute stage of the disease and after follow-up.


METHODS
Horses (n = 12) diagnosed with AM in which cardiac ultrasound examination and ECG recording were available.


METHODS
All horses underwent clinical examinations, serum biochemistry, electrocardiography, and echocardiography. Four surviving horses underwent the same examinations after 2-10 weeks.


RESULTS
All but 1 horse had increased cardiac troponin I concentrations and 10 horses had ventricular premature depolarizations (VPDs). All horses had prolonged corrected QT (QT(cf) ) intervals on the day of admission and abnormal myocardial wall motion on echocardiography. One of the surviving horses still had VPDs and prolonged QT(cf) at follow-up after 10 weeks.


CONCLUSIONS
The AM results in characteristic electrocardiographic and echocardiographic changes and may be associated with increased cardiac troponin I concentrations and VPDs. In survivors, abnormal cardiac function still may be found at follow-up after 10 weeks. Additional research in a larger group of horses is necessary to identify the long-term effects of AM on cardiac function.
Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Belgium. tinne.verheyen@ugent.be
T
T
Verheyen
A
A
Decloedt
D
D
De Clercq
G
G
van Loon
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D004452:Echocardiography / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006736:Horses; D008297:Male; D012206:Rhabdomyolysis / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D019210:Troponin I / Q000097:blood
D019210:Troponin I