AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.
BACKGROUND
Alzheimer's disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.


METHODS
Here, we have constructed a publicly available pathway map called "AlzPathway" that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers.


CONCLUSIONS
AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/.
Department of Bioinformatics, Tokyo Medical and Dental University, Yushima 1-5-45, Tokyo, 113-8510, Japan.
Satoshi
S
Mizuno
Risa
R
Iijima
Soichi
S
Ogishima
Masataka
M
Kikuchi
Yukiko
Y
Matsuoka
Samik
S
Ghosh
Tadashi
T
Miyamoto
Akinori
A
Miyashita
Ryozo
R
Kuwano
Hiroshi
H
Tanaka
D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis; D017423:Sequence Analysis, RNA; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods*