Posterior circulation stroke: animal models and mechanism of disease.
Posterior circulation stroke refers to the vascular occlusion or bleeding, arising from the vertebrobasilar vasculature of the brain. Clinical studies show that individuals who experience posterior circulation stroke will develop significant brain injury, neurologic dysfunction, or death. Yet the therapeutic needs of this patient subpopulation remain largely unknown. Thus understanding the causative factors and the pathogenesis of brain damage is important, if posterior circulation stroke is to be prevented or treated. Appropriate animal models are necessary to achieve this understanding. This paper critically integrates the neurovascular and pathophysiological features gleaned from posterior circulation stroke animal models into clinical correlations.
Division of Physiology, Department of Basic Science, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, CA 92354, USA. tlekic@llu.edu
Tim
T
Lekic
Chizobam
C
Ani
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020521:Stroke / Q000473:pathology*; D014715:Vertebrobasilar Insufficiency / Q000473:pathology*