Near-infrared light-responsive intracellular drug and siRNA release using au nanoensembles with oligonucleotide-capped silica shell.
Taking advantage of the character of Au nanorods (NRs) to absorb NIR light, a NIR-responsive oligonucleotide-gated ensemble is developed to perform intracellular drug delivery. Using an oligonucleotide bio-gate enables siRNA release into cells for translational regulation as well as cytotoxicity in anti-cancer drug delivery.
Department of Chemistry and Center for Micro/Nano Science and Technology, National Cheng Kung University, Tainan, 701 Taiwan.
Yi-Ting
YT
Chang
Pei-Yi
PY
Liao
Hwo-Shuenn
HS
Sheu
Yu-Jui
YJ
Tseng
Fong-Yu
FY
Cheng
Chen-Sheng
CS
Yeh
D000042:Absorption; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D043942:Nanotubes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000378:metabolism*; D012822:Silicon Dioxide / Q000737:chemistry*
D000970:Antineoplastic Agents; D004337:Drug Carriers; D009841:Oligonucleotides; D034741:RNA, Small Interfering; D006046:Gold; D012822:Silicon Dioxide