[Metastatic apocrine adenocarcinoma of the penis: cytostatic therapy].
Metastatic carcinoma of the genital apocrine sweat glands is a rare clinical entity. A cytostatic treatment with MTX and bleomycin was performed empirically but did not show any satisfactory efficacy. The conversion of the chemotherapeutic regime to a tyrosine kinase inhibitor (sunitinib) showed a morphologically visible and clinically proven success in terms of a significant slowing down of the previous rapid progression of the disease.
Universitätsklinikum der RWTH Aachen, Klinik für Urologie, Deutschland. jvanessen@ukaachen.de
J
J
van Essen
A
A
Heidenreich
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001050:Apocrine Glands; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018450:Disease Progression; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D049268:Positron-Emission Tomography; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000009:adverse effects / Q000627:therapeutic use*; D000077210:Sunitinib; D013544:Sweat Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; D000077210:Sunitinib