CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value.
Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value.
Servicio de Hematología, Hospital Universitario, 'Dr. José E. González' Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Manuel
M
Solano-Genesta
Luz
L
Tarín-Arzaga
Ileana
I
Velasco-Ruiz
Julia A
JA
Lutz-Presno
Oscar
O
González-Llano
Consuelo
C
Mancías-Guerra
Laura
L
Rodríguez-Romo
Guillermo J
GJ
Ruiz-Delgado
Guillermo J
GJ
Ruiz-Argüelles
José Carlos
JC
Jaime-Pérez
David
D
Gómez-Almaguer
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies
D018951:Antigens, CD20; D014408:Biomarkers, Tumor