Anacardium occidentale Linn. (Anacardiaceae) stem bark extract induces hypotensive and cardio-inhibitory effects in experimental animal models.
Anacardium occidentale Linn. (Anacardiaceae) is a plant largely used in Africa for the treatment of different diseases. In Côte d'Ivoire it's commonly used for the treatment of hypertension. The present study was carried out in order to assess the effects of Anacardium occidentale extract (ANOE) on cardiovascular parameters in animal models. A mercury manometer kymograph of Ludwig was used to measure the blood pressure of normotensive rabbits in control conditions (normal physiological solution) and under the influence of ANOE. The contractile activity of an isolated rat heart was also measured in control conditions and under the influence of ANOE in different physiological media using a modified Langendhorff (1895) apparatus. The aqueous Anacardium occidentale (ANOE) bark extract applied intravenously in different doses (12, 40, 90, and 167 mg/kg b.w.), produced a significant dose-dependent decrease in blood pressure of previously normotensive rabbits (up to 89% vs control). Atropine (1 mg/ml) pre-treatment failed to reverse the hypotensive effects elicited by the extract. ANOE applied to isolated rat heart preparations in different concentrations (0.01, 0.1, 1.0, and 10 µg/ml) induced negative inotropic and chronotropic effects. Atropine pre-treatment of heart preparations (0.1 µg/ml) failed to reverse the negative effects induced by ANOE. The extract's action on heart contractile activity studied in modified culture media further confirmed its cardio-inhibitory effects. ANOE induced strong hypotensive and cardio-inhibitory effects in animal models.
Laboratoire de Nutrition et Pharmacologie, Département de Biologie Animale et Physiologie, UFR-Biosciences, Université de Cocody, Abidjan, Côte d'Ivoire, 20 BP 947 Abidjan 20, Côte d'Ivoire. ftchikaya@hotmail.com
Francis Olivier
FO
Tchikaya
Guy Bernard
GB
Bantsielé
Gisèle
G
Kouakou-Siransy
Jacques Yao
JY
Datté
Paul Angoue
PA
Yapo
Noel Guedé
NG
Zirihi
Michel Atté
MA
Offoumou
D031021:Anacardium; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D023421:Models, Animal; D009200:Myocardial Contraction / Q000187:drug effects*; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D018547:Plant Stems; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts