The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease.
A higher oxidative stress may contribute to the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the relationship between coenzyme Q10 concentration and lipid peroxidation, antioxidant enzymes activities and the risk of CAD. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery were assigned to the case group (n = 51). The control group (n = 102) comprised healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, malondialdehyde (MDA) and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) were measured. Subjects with CAD had significant lower plasma coenzyme Q10, CAT and GPx activities and higher MDA and SOD levels compared to those of the control group. The plasma coenzyme Q10 was positively correlated with CAT and GPx activities and negatively correlated with MDA and SOD. However, the correlations were not significant after adjusting for the potential confounders of CAD with the exception of SOD. A higher level of plasma coenzyme Q10 (≥ 0.52 μmol/L) was significantly associated with reducing the risk of CAD. Our results support the potential cardioprotective impact of coenzyme Q10.
School of Nutrition, Chung Shan Medical University, No 110, Section 1, Jianguo N Road, Taichung 40201, Taiwan.
Bor-Jen
BJ
Lee
Yi-Chin
YC
Lin
Yi-Chia
YC
Huang
Ya-Wen
YW
Ko
Simon
S
Hsia
Ping-Ting
PT
Lin
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D003251:Constriction, Pathologic; D003324:Coronary Artery Disease / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D012306:Risk; D013482:Superoxide Dismutase / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
D000975:Antioxidants; D014451:Ubiquinone; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C024989:coenzyme Q10