Assessment of the selected biochemical markers in predicting preterm labour.
OBJECTIVE
The differential diagnosis between preterm and false labour remains one of the most challenging issues in perinatal medicine.


OBJECTIVE
To assess the prognostic importance of the selected biochemical markers in predicting preterm labour.


METHODS
74 patients hospitalized due to threatening preterm labour. 51 women gave birth prematurely; the remaining 23 were diagnosed with false labour. We used ELISA arrays to study 13 proteins: IGFBP-1, IGFBP-2, BDNF, L-Selectin, E-Selectin, ICAM-1, PECAM, VCAM-1, MIP-1 delta (MIP-1d) MIP-3β (MIP-3b), Eotaxin-1, Eotaxin-2, BLC.


RESULTS
An increased risk of preterm labour should be expected when the serum concentration for: IGFBP-1 > 158.83 pg/ml (sens. 0.608, sp. 0.609, p < 0.0001); MIP-1d < 27.66 pg/ml (sens. 0.627, sp. 0.627, p = 0.021); BDNF >36.54 pg/ml (sens. 0.630, sp. 0.647, p = 0.002); BLC >25.46 pg/ml (sens. 0.588, sp. 0.609, p < 0.001); Eotaxin-1 >1.16 pg/ml (sens. 0.633, sp. 0.652).


CONCLUSIONS
There have been reported statistically significant differences in serum concentrations of selected proteins in women with preterm labour and false labour.
Department of Perinatology, Medical University of Białystok, Poland.
Piotr
P
Laudanski
Grzegorz
G
Raba
Pawel
P
Kuc
Adam
A
Lemancewicz
Rafał
R
Kisielewski
Tadeusz
T
Laudanski
D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000097:blood; D018925:Chemokines / Q000032:analysis / Q000097:blood; D019742:Chemokines, CC / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000032:analysis / Q000097:blood; D019041:L-Selectin / Q000032:analysis / Q000097:blood; D019402:Macrophage Inflammatory Proteins / Q000032:analysis / Q000097:blood; D007752:Obstetric Labor, Premature / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D012680:Sensitivity and Specificity
D015415:Biomarkers; C108814:CCL15 protein, human; D015815:Cell Adhesion Molecules; D018925:Chemokines; D019742:Chemokines, CC; D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D019402:Macrophage Inflammatory Proteins; D019041:L-Selectin