Regulatory modules: Coupling protein stability to phopshoregulation during cell division.
Multiple post-translational regulation systems regulate cell biology. Two key mechanisms that coordinate the myriad processes of cell replication are phosphorylation and ubiquitin-mediated degradation of proteins. Regulatory modules have evolved to integrate these two control systems at key decision points in the cell division cycle. These modules enable information to be processed with high fidelity by filtering noise, improving specificity, generating feedback loops, and optimizing spatiotemporal coordination of cellular processes. This review provides examples of these modules and considers the advantages of this signaling nexus.
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. ljholt@gmail.com
Liam J
LJ
Holt
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D004249:DNA Damage; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes
D011506:Proteins; D014157:Transcription Factors; D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome