[Plant-specific type III polyketide synthases superfamily: crystal structures and functions].
Plant type III polyketide synthase (PKS) generates backbones of a variety of plant secondary metabolites with diverse functions, and has long been models to elucidate the relationship between the three-dimensional structure and function. More than 80 type IIII PKS crystal structures with different functions have been reported in Protein Data Bank, including the crystal structures of the well-studied Chalcone Synthase of plant type III PKS, as well as the 6 other kinds of PKSs in the family, which are critical for understanding the structural basis for diverse starter molecule selectivity, polyketide chain length and the cyclization reaction. Structure-based analysis and site-directed mutagenesis are foundation for the investigation of enzyme engineering, genetic and metabolic engineering. This review summarized 7 plant-specific type III PKS in the aspects of their crystal structures and functions.
Key Laboratory of Urban Agriculture North) of Ministry of Agriculture China, Beijing University of Agriculture, Beijing 102206, China.
Heshu
H
Lü
Chunmei
C
Liu
Ping
P
Lu
Guanglu
G
Shi
Lanqing
L
Ma
Younian
Y
Wang
D000217:Acyltransferases / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence; D002384:Catalysis; D047188:Chalcones; D003460:Crystallization; D044950:Flavanones; D005818:Genetic Engineering; D060847:Metabolic Engineering; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D010944:Plants / Q000201:enzymology* / Q000235:genetics; D017433:Protein Structure, Secondary; D013379:Substrate Specificity
D047188:Chalcones; D044950:Flavanones; D010940:Plant Proteins; D000217:Acyltransferases; C020141:flavanone synthetase