Techniques for the discovery and evaluation of drugs against alopecia.
BACKGROUND
Hair care, color and style play an important role in physical appearance and self-perception. Hair loss or alopecia is a common dermatological and affective disorder. Factors contributing to alopecia include genetic predisposition, hormonal factors, disease status, side effects of chemotherapeutic agents and stress. To keep pace with the demand for drugs for alopecia, attempts are being made to explore drugs with hair-growth-promotion activity. To explore and evaluate these, it is necessary to be familiar with the basics and the availability and suitability of techniques and experimental models of hair growth activity assessment.


METHODS
Basic and advanced techniques and models for assessing hair growth activity. A variety of pharmacological models of hair growth are reviewed. This review will help in selecting a suitable, relevant, inexpensive, easy and reliable model for hair growth assessment.


CONCLUSIONS
There is a need to identify the genes involved in hair follicle growth for the production of more effective animal models of the disorder. Standardization of pharmacological models will also be essential for better comparison and validation of results. Recently developed hair follicle organ culture models are a suitable, relevant and inexpensive alternative to traditional whole-animal pharmacological models and will, largely, replace whole-animal systems in the future.
H.NB Garhwal (Central) University Srinagar, Department of Pharmaceutical Sciences, PB No.-106, Garhwal 246174, Uttarakhand, India  +91 1346 211502 ;  +91 1346 252174 ;  semaltyajay@yahoo.co.in.
Ajay
A
Semalty
Mona
M
Semalty
Geeta Pant
GP
Joshi
Mohan Singh Maniyari
MS
Rawat