Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.
BACKGROUND
Fatty acids provide energy and structural substrates for the heart and brain and may influence resuscitation from sudden cardiac arrest (SCA). We investigated whether genetic variation in fatty acid metabolism pathways was associated with SCA survival.


RESULTS
Subjects (mean age, 67 years; 80% male, white) were out-of-hospital SCA patients found in ventricular fibrillation in King County, WA. We compared subjects who survived to hospital admission (n=664) with those who did not (n=689), and subjects who survived to hospital discharge (n=334) with those who did not (n=1019). Associations between survival and genetic variants were assessed using logistic regression adjusting for age, sex, location, time to arrival of paramedics, whether the event was witnessed, and receipt of bystander cardiopulmonary resuscitation. Within-gene permutation tests were used to correct for multiple comparisons. Variants in 5 genes were significantly associated with SCA survival. After correction for multiple comparisons, single-nucleotide polymorphisms in ACSL1 and ACSL3 were significantly associated with survival to hospital admission. Single-nucleotide polymorphisms in ACSL3, AGPAT3, MLYCD, and SLC27A6 were significantly associated with survival to hospital discharge.


CONCLUSIONS
Our findings indicate that variants in genes important in fatty acid metabolism are associated with SCA survival in this population.
Department of Medicine, University of Washington CHRU, 1730 Minor Ave, Seattle, WA 98101, USA. johnsoco@uw.edu
Catherine O
CO
Johnson
Rozenn N
RN
Lemaitre
Carol E
CE
Fahrenbruch
Stephanie
S
Hesselson
Nona
N
Sotoodehnia
Barbara
B
McKnight
Kenneth M
KM
Rice
Pui-Yan
PY
Kwok
David S
DS
Siscovick
Thomas D
TD
Rea
D000368:Aged; D016887:Cardiopulmonary Resuscitation; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016019:Survival Analysis
D005227:Fatty Acids