[Pharmacokinetics of iron medication and efficacy of therapy with oral iron supplementation].
The pharmacokinetics of iron oral medication in was studied in patients with liver cirhorosis. In patients with hepatocellular insufficiency and high level of gepsidin found a decrease of the iron absorption constant, which led to a change in pharmacokinetic parameters. Tests on the absorption of iron have been conducted in 25 patients with liver cirrhosis, 36% of them showed a decrease of iron absorption, which led to the decrease in the efficiency of subsequent iron therapy. Found that elevated levels of gepsidin that lead to violation of iron metabolism and absorption and reduce the effectiveness of the treatment of iron deficiency.
V N
VN
Drozdov
K K
KK
Noskova
A V
AV
Petrakov
E A
EA
Mel'kina
L A
LA
Fedulenkova
A V
AV
Lishchinskaia
D000284:Administration, Oral; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D023181:Antimicrobial Cationic Peptides; D005296:Ferrous Compounds; D064451:Hepcidins; C020748:ferrous sulfate; D007501:Iron