Cachexia and herbal medicine: perspective.
Kampo, a form of traditional herbal medical practice, has become a substance of interest for scientific research. Although earlier clinical reports concerning Kampo are abundant, the scientific investigation of Kampo has a very short history. However, the process of acquiring quantifiable clinical trial evidence on herbal medicine is now clearly underway. The development of multi-component herbal medicines capable of targeting multiple sites could be useful both for future drug discovery and for the potential management of complex diseases. Additionally, mechanistic studies and the identification of active compounds could lead to new discoveries in the biological and biomedical sciences. Modern translational research on herbal medicines beyond basic science and clinical perspectives will contribute to the development of new medicines. This review covers the translational aspects of herbal medicine with a focus on cancer anorexiacachexia. The review gives perspective on a new horizon for herbal medicine from a scientific point of view and a basis for the further development of complementary and alternative medicine (CAM) for patients.
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Hajime
H
Suzuki
Akihiro
A
Asakawa
Haruka
H
Amitani
Norifumi
N
Nakamura
Akio
A
Inui
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D019167:Appetite Stimulants / Q000494:pharmacology / Q000627:therapeutic use*; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D054439:Ghrelin / Q000819:agonists / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D020835:Medicine, Kampo; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D054440:Receptors, Ghrelin / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D057170:Translational Research, Biomedical / Q000639:trends*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D019167:Appetite Stimulants; C515349:GHRL protein, human; D054439:Ghrelin; D028321:Plant Preparations; D054440:Receptors, Ghrelin