Advanced neuroimaging techniques in the management of glioblastoma multiforme.
Despite the extensive research efforts over the past century, glioblastoma multiforme (GBM) remains an ominous diagnosis leading fast to progressive disability and death despite the aggressive treatment including microsurgical resection, chemotherapy, radiotherapy and stereotactic radiosurgery. Advanced neuroimaging techniques, such as volumetric acquisitions, spectroscopy, diffusion and perfusion studies added to conventional imaging, provide in selected cases a non-invasive alternative to pathological diagnosis but they are also precious tools to define the boundaries of image-guided microsurgical resection and/or radiosurgical ablation. This paper reviews the role of advanced neuroimaging techniques in the diagnosis and treatment of GBM.
IRCCS Neuromed, Pozzilli (Isernia), Italy.
Claudio
C
Colonnese
Pantaleo
P
Romanelli
D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000601:surgery; D005909:Glioblastoma / Q000098:blood supply / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009389:Neovascularization, Pathologic / Q000175:diagnosis; D059906:Neuroimaging / Q000379:methods*; D016634:Radiosurgery; D014057:Tomography, X-Ray Computed