Flexible rule use: common neural substrates in children and adults.
Flexible rule-guided behavior develops gradually, and requires the ability to remember the rules, switch between them as needed, and implement them in the face of competing information. Our goals for this study were twofold: first, to assess whether these components of rule-guided behavior are separable at the neural level, and second, to identify age-related differences in one or more component that could support the emergence of increasingly accurate and flexible rule use over development. We collected event-related fMRI data while 36 children aged 8-13 and adults aged 20-27 performed a task that manipulated rule representation, rule switching, and stimulus incongruency. Several regions - left dorsolateral prefrontal cortex (DLPFC), left posterior parietal cortex, and pre-supplementary motor area - were engaged by both the rule representation and the rule-switching manipulations. These regions were engaged similarly across age groups, though contrasting timecourses of activation in left DLPFC suggest that children updated task rules more slowly than did adults. These findings support the idea that common networks can contribute to a variety of executive functions, and that some developmental changes take the form of changes in temporal dynamics rather than qualitative changes in the network of brain regions engaged.
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA. cwendelken@berkeley.edu
Carter
C
Wendelken
Yuko
Y
Munakata
Carol
C
Baym
Michael
M
Souza
Silvia A
SA
Bunge
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D001076:Aptitude; D002648:Child; D003071:Cognition / Q000502:physiology*; D003463:Cues; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000254:growth & development / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012054:Reinforcement, Psychology; D012927:Social Control, Informal; D055815:Young Adult