Interaction between GUVs and catanionic nanocontainers: new insight into spontaneous membrane fusion.
Spontaneous receptor-free membrane fusion with pure lipid systems, used as a cell membrane model, is demonstrated with easy-to-handle lactose-derived catanionic vesicles. This fusion, mediated and controlled by phospholipids, emphasizes the great value of these nanovesicles for enhanced direct cytosolic drug delivery without the shortcomings linked with endocytic pathways.
Laboratoire IMRCP, UMR 5623 CNRS, Université Toulouse 3, 118 route de Narbonne, 31062 Toulouse, France.
Chloé
C
Mauroy
Pauline
P
Castagnos
Marie-Claire
MC
Blache
Justin
J
Teissié
Isabelle
I
Rico-Lattes
Marie-Pierre
MP
Rols
Muriel
M
Blanzat
D002412:Cations; D002462:Cell Membrane / Q000737:chemistry*; D008561:Membrane Fusion; D008954:Models, Biological; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D053835:Unilamellar Liposomes / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D002412:Cations; D013501:Surface-Active Agents; D053835:Unilamellar Liposomes; D014867:Water