A novel sensor based on electrochemical polymerization of diglycolic acid for determination of acetaminophen.
Diglycolic acid (DA) polymer was coated on glassy carbon (GC) electrode by cyclic voltammetry (CV) technique for the first time. The electrochemical performances of the modified electrode were investigated by CV and electrochemical impedance (EIS). The obtained electrode showed an excellent electrocatalytic activity for the oxidation of acetaminophen (ACOP). A couple of well-defined reversible electrochemical redox peaks were observed on the ploy(DA)/GC electrode in ACOP solution. Compared with bare GC electrode, the oxidation peak potential of ACOP on ploy(DA)/GC electrode moved from 0.289 V to 0.220 V. Meanwhile, the oxidation peak current was much higher on the modified electrode than that on the bare GC electrode, indicating DA polymer modified electrode possessed excellent performance for the oxidation of ACOP. This kind of capability of the modified electrode can be enlisted for the highly sensitive and selective determination of ACOP. Under the optimized conditions, a wide linear range from 2 × 10(-8) to 5.0 × 10(-4)M with a correlation coefficient 0.9995 was obtained. The detection limit was 6.7 × 10(-9)M (at the ratio of signal to noise, S/N=3:1). The modified electrode also exhibited very good stability and reproducibility for the detection of ACOP. The established method was applied to the determination of ACOP in samples. An average recovery of 100.1% was achieved. These results indicated that this method was reliable for determining ACOP.
College of Chemistry and Chemical Engineering, Liaoning Normal University, 850 Huanghe Road, Dalian 116029, PR China. xufen@lnnu.edu.cn
Fen
F
Xu
Hui-Ying
HY
Ru
Li-Xian
LX
Sun
Yong-Jin
YJ
Zou
Cheng-Li
CL
Jiao
Tao-Yi
TY
Wang
Jia-Ming
JM
Zhang
Qian
Q
Zheng
Huai-Ying
HY
Zhou
D000082:Acetaminophen / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000032:analysis*; D002244:Carbon / Q000737:chemistry; D017097:Electric Impedance; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006016:Glycolates / Q000737:chemistry*; D057230:Limit of Detection; D010084:Oxidation-Reduction; D058105:Polymerization; D015203:Reproducibility of Results
D018712:Analgesics, Non-Narcotic; D006016:Glycolates; D000082:Acetaminophen; D002244:Carbon; C571256:diglycolic acid