Association of total iron binding capacity with coronary artery disease.
OBJECTIVE
A case-control study and a meta-analysis were conducted to assess the association between total iron binding capacity (TIBC) and coronary artery disease (CAD) risk.


METHODS
A hospital-based case-control study was conducted with 258 CAD cases and 282 healthy controls. Logistic regression was utilized to estimate odds ratio (OR) with 95% confidence interval (CI) and adjust potential confounders. Dose-response relation was investigated between TIBC and CAD risk by dividing TIBC concentration into quartiles. A meta-analysis was performed on the standardized mean difference (SMD) as well as OR.


RESULTS
In our case-control study, TIBC was found associated with decreased CAD risk both in univariate (OR=0.981, 95% CI=0.975, 0.986) and multivariate (OR=0.979, 95% CI=0.972, 0.986) adjusted logistic regressions. The multivariate-adjusted OR for the highest quartile compared with the lowest quartile was 0.087 (95% CI=0.042, 0.181). After sensitivity analysis, the meta-analysis on SMD showed that TIBC was associated with decreased CAD risk (SMD=-0.211, 95% CI=-0.318, -0.104). The results of pooled measure on OR (OR=0.970, 95% CI=0.946, 0.995) were consistent with those of SMD analysis.


CONCLUSIONS
A weak association was found between TIBC levels and decreased CAD risk, further investigations are necessary to clarify the dose-response relationship.
Department of Epidemiology and Health Statistics, Shandong University, PR China.
Peipei
P
Kang
Tongtao
T
Liu
Changwei
C
Tian
Yunping
Y
Zhou
Chongqi
C
Jia
D000704:Analysis of Variance; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000503:physiopathology; D016206:Databases, Bibliographic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism*
D014168:Transferrin; D007501:Iron