Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration.
OBJECTIVE
We investigated the effectiveness and safety of topical application of 5 mg allicin adhesive tablets in the treatment of minor recurrent aphthous ulcerations (MiRAU).


METHODS
A randomized, double-blinded, placebo-controlled, clinical trial was performed. Tablets containing 5 mg allicin or vehicle only were consecutively applied 4 times per day for 5 days. The size and pain level of ulcers were measured and recorded on days 1, 2, 4, and 6.


RESULTS
A total of 96 subjects with MiRAU fulfilled the study. Allicin adhesive tablets significantly reduced ulcer size (P < .005, P < .003, P < .001 for days 2, 4, and 6, respectively) and alleviated ulcer pain score (P < .03, P < .001, P < .05 for days 2, 4, and 6, respectively) compared with vehicle tablets. Minor and major adverse reactions were not observed.


CONCLUSIONS
Allicin adhesive tablets were effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of MiRAU without significant side effects.
Department of Stomatology, the First People's Hospital of Chenzhou, Chenzhou, China. jxw0927@yahoo.com.cn
Xiao-Wen
XW
Jiang
Yi
Y
Zhang
Guo-Dong
GD
Song
Fen-Fang
FF
Li
Hai-Yan
HY
Peng
Shou-Kang
SK
Yang
Guo-Liang
GL
Sun
D000269:Adhesives / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D004220:Disulfides; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013281:Stomatitis, Aphthous / Q000188:drug therapy*; D013441:Sulfinic Acids / Q000627:therapeutic use*; D013607:Tablets; D016896:Treatment Outcome; D055815:Young Adult
D000269:Adhesives; D004220:Disulfides; D013441:Sulfinic Acids; D013607:Tablets; C006452:allicin