Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: a case report.
The radiation-induced fibroatrophic process (RIF) is a time-dependent adverse sequela to high-dose radiotherapy that can result in irreversible tissue death and bone exposure in the irradiated tissue. Osteoradionecrosis (ORN) is a late effect of RIF, described as bony exposure present for more than 3 months that can occur in 20% of patients irradiated for head and neck cancer. The intractable characteristics of ORN make both management and resolution of the disease process challenging, with 25% of cases recurring despite aggressive treatment with resection and reconstruction of the necrotic bone. In this article, we present a case of a 66-year-old man with unevoked ORN of the left posterior lingual mandibular cortex that was successfully treated and resolved with 6 months of pentoxifylline 400 mg twice a day and tocopherol 1000 IU every day.
Section of Oral & Maxillofacial Surgery, University of California, Los Angeles, School of Dentistry, Los Angeles, California 90095, USA.
Nora
N
Kahenasa
Eric C
EC
Sung
Vishad
V
Nabili
Jim
J
Kelly
Neal
N
Garrett
Ichiro
I
Nishimura
D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D016371:Cranial Irradiation / Q000009:adverse effects; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy* / Q000209:etiology; D010025:Osteoradionecrosis / Q000188:drug therapy* / Q000209:etiology; D010431:Pentoxifylline / Q000627:therapeutic use*; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D014067:Tonsillar Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D024502:alpha-Tocopherol / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D024502:alpha-Tocopherol; D010431:Pentoxifylline