[Determination of circulation disturbance in the rat lungs in modelling of chronic obstructive disease].
Development of chronic obstructive pulmonary disease (COPD) involves not only the bronchial and respiratory areas of the lungs, but also the system of pulmonary circulation, which begins with the defeat of capillary blood flow. One of radiological methods of studying lung microcirculatory functions is perfusion scintigraphy. We designed the technique of radiological examination and identified its abilities in determination of the role of vascular dysfunctions in experimental model of development of COPD. We assessed the results of pharmacological agents that affect the microcirculatory bed of the lungs and smooth muscles of pulmonary arteries in rats. Studies have shown the promise of the possibility of using the drug sulodexide for studying impaired endothelial function in clinical practice.
V P
VP
Zolotnitskaia
E S
ES
Lebedev
A N
AN
Fedin
N A
NA
Kuzubova
T D
TD
Vlasov
D000818:Animals; D004195:Disease Models, Animal; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D008168:Lung / Q000098:blood supply* / Q000503:physiopathology*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000503:physiopathology; D009585:Nitrogen Dioxide / Q000008:administration & dosage*; D009924:Organ Culture Techniques; D011651:Pulmonary Artery / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage
D006025:Glycosaminoglycans; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C007858:glucuronyl glucosamine glycan sulfate; D009585:Nitrogen Dioxide