Inner- and outer-sphere metal coordination in blue copper proteins.
Blue copper proteins (BCPs) comprise classic cases of Nature's profound control over the electronic structures and chemical reactivity of transition metal ions. Early studies of BCPs focused on their inner coordination spheres, that is, residues that directly coordinate Cu. Equally important are the electronic and geometric perturbations to these ligands provided by the outer coordination sphere. In this tribute to Hans Freeman, we review investigations that have advanced the understanding of how inner-sphere and outer-sphere coordination affects biological Cu properties.
Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.
Jeffrey J
JJ
Warren
Kyle M
KM
Lancaster
John H
JH
Richards
Harry B
HB
Gray
D002352:Carrier Proteins / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008667:Metalloproteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D002352:Carrier Proteins; D008667:Metalloproteins; C023548:copper-binding protein; D003300:Copper