A case of acute disseminated encephalomyelitis associated with hepatitis C virus infection.
Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating disease of the central nervous system, which typically follows acute viral or bacterial infection or vaccination. We report a case of ADEM associated with hepatitis C virus (HCV) infection with positive serum and cerebrospinal fluid (CSF) anti-HCV antibody. After steroid treatment, neurologic symptoms were improved. Virus triggers autoimmunity or direct viral invasion plays a part in the genesis of ADEM. This is the first reported case of ADEM with anti-HCV antibody in the CSF.
Department of Neurology, Severance Institute for Vascular and Metabolic Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Jae Eun
JE
Sim
Jun-Bum
JB
Lee
Yu Na
YN
Cho
Sang Hyun
SH
Suh
Ja Kyung
JK
Kim
Kyung-Yul
KY
Lee
D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged
D008775:Methylprednisolone