MicroRNAs: molecular features and role in cancer.
microRNAs (miRNAs) are small noncoding endogenously produced RNAs that play key roles in controlling the expression of many cellular proteins. Once they are recruited and incorporated into a ribonucleoprotein complex miRISC, they can target specific mRNAs in a miRNA sequence-dependent process and interfere in the translation into proteins of the targeted mRNAs via several mechanisms. Consequently, miRNAs can regulate many cellular pathways and processes. Dysregulation of their physiological roles may largely contribute to disease. In particular, in cancer, miRNAs can be involved in the deregulation of the expression of important genes that play key roles in tumorigenesis, tumor development, and angiogenesis and have oncogenic or tumor suppressor roles. This review focuses on the biogenesis and maturation of miRNAs, their mechanisms of gene regulation, and the way their expression is deregulated in cancer. The involvement of miRNAs in several oncogenic pathways such as angiogenesis and apoptosis, and in the inter-cellular dialog mediated by miRNA-loaded exosomes as well as the development of new therapeutical strategies based on miRNAs will be discussed.
INSERM, U836, Team7 Nanomedicine and Brain, BP 170, Grenoble, France.
Elodie
E
Lages
Helene
H
Ipas
Audrey
A
Guttin
Houssam
H
Nesr
Francois
F
Berger
Jean-Paul
JP
Issartel
D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism* / Q000627:therapeutic use; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D034743:RNA-Induced Silencing Complex