Detection of autoantibodies and increased concentrations of interleukins in plasma from patients with Tourette's syndrome.
The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n = 40) and healthy control individuals (n = 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group (P < 0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group (P < 0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group (P < 0.05). These findings suggest that immune activity is altered in patients with TS.
Clinical Examination and Experimental Center, Beijing An Ding Hospital, Capital Medical University, Beijing, 100088, People's Republic of China.
Yu-hang
YH
Cheng
Yi
Y
Zheng
Fan
F
He
Jian-hong
JH
Yang
Wen-biao
WB
Li
Min-ling
ML
Wang
De-yan
DY
Cui
Ying
Y
Chen
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D050822:Cytokine Receptor gp130 / Q000097:blood; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D019947:Receptors, Interleukin-6 / Q000097:blood; D016036:Seroepidemiologic Studies; D005879:Tourette Syndrome / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D055815:Young Adult
D001323:Autoantibodies; D015415:Biomarkers; C508717:IL17A protein, human; C508600:IL6 protein, human; C508603:IL6R protein, human; D020381:Interleukin-17; D053583:Interleukin-1beta; D015850:Interleukin-6; D007378:Interleukins; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130