Sesquiterpenes and an intermediate 1alpha, 6beta, 11-eudesmanetriol in the biosynthesis of geosmin from Streptomyces sp.
One new sesquiterpene was isolated from the fermentation broth of Streptomyces sp. and the structure was elucidated by spectral analysis as caryolane-1, 6beta-diol (1). An intermediate 1alpha, 6beta, 11-eudesmanetriol (2) in the biosynthesis of geosmin was also found in this strain which proved sequence for the reactions, especially bicyclization preceding dealkylation.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Ya-Bin
YB
Yang
Zhi
Z
Yang
Xue-Qiong
XQ
Yang
Yong
Y
Zhang
Li-Xing
LX
Zhao
Li-Hua
LH
Xu
Zhong-Tao
ZT
Ding
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry* / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
C582744:1alpha,6beta,11-eudesmanetriol; D009284:Naphthols; D012717:Sesquiterpenes; C582743:caryolane-1,6beta-diol; C001278:geosmin