Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: study and human post-mortem examination.
The involvement of psychotropic drugs in sudden deaths has been highlighted. The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem in heart, brain and liver. Histological examination evidenced dilated cardiomyopathy in 45% of cases, left ventricular hypertrophy in 36%, and ischemic coronaropathy in 18%. A significant reduction of myocardial selenium levels compared to controls was seen in patients treated with neuroleptic drugs or meprobamate. No changes in brain or liver selenium levels were seen. These results suggest that selenium deficiency can facilitate sudden death in patients on psychotropic drugs. The reduced activity of glutathione peroxidase due to selenium deficiency can result in augmented oxidative stress in myocardial cells and myocardiopathy leading to sudden death.
Laboratory of Medical Pharmacology, EA 4612 Neurocardiology, Lyon, France.
Lamia
L
Hamdan
Muriel
M
Bost
Guy
G
Chazot
Bernard
B
Bui-Xuan
Fanny
F
Vaillant
Leila
L
Dehina
Jacques
J
Descotes
Alain
A
Tabib
Zahida
Z
Mamou
Quadiri
Q
Timour
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001344:Autopsy; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000172:deficiency*
D014150:Antipsychotic Agents; D012643:Selenium