Synthesis and neuropharmacological evaluation of some novel quinoxaline 2, 3-dione derivatives.
Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using (1)H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer test were performed. Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration.
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Off Campus, JSS University, Mysore 570015, India. jubiejawahar@gmail.com
Selvaraj
S
Jubie
Rajamanickam
R
Gayathri
Rajagopal
R
Kalirajan
D000818:Animals; D004996:Ethidium; D005106:Exploratory Behavior / Q000187:drug effects; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009468:Neuromuscular Diseases / Q000139:chemically induced / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D008352:Mannich Bases; D018696:Neuroprotective Agents; D011810:Quinoxalines; D004996:Ethidium