Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: a Chinese cohort study.
OBJECTIVE
Little is known about serum uric acid (SUA) role for hypertension in the Asian countries with low cardiovascular events. We aimed to explore the relationship in a comprehensive Chinese cohort.


METHODS
Participants in the Taiwanese Survey on Prevalences of Hypertension, Hyperglycemia, and Hyperlipidemia (TwSHHH) who were free of hypertension at baseline recruitment in 2002 (n=3257) were evaluated for the longitudinal association between baseline SUA and blood pressure progression (BPP) and incident hypertension.


RESULTS
During a mean follow-up of 5.41 years, 1119 persons (34.3%) had experienced progression to a higher blood pressure stage and 496 persons (15.2%) had developed hypertension. In multivariate analyses, the adjusted hazard ratios (HRs) [95% confidence intervals (CIs)] comparing the highest and lowest SUA quartiles were 1.78 (1.11-2.02, P for trend .004) for BPP and 1.68 (1.23-2.04, P for trend .028) for incident hypertension. The positively graded relationships between SUA concentration and blood pressure outcomes were observed in both males and females. More interestingly, a statistically significant trend for increasing risk of BPP and incident hypertension across SUA quartiles was most pronounced in participants with abdominal obesity.


CONCLUSIONS
We concluded that SUA level was an independent predictor of blood pressure progression and incident hypertension in a Chinese population.
Department of Health Business Administration, Meiho University, Pingtung, County, Taiwan.
Tsan
T
Yang
Chi-Hong
CH
Chu
Chyi-Huey
CH
Bai
San-Lin
SL
You
Yu-Ching
YC
Chou
Lee-Ching
LC
Hwang
Kuo-Liong
KL
Chien
Ta-Chen
TC
Su
Chin-Hsiao
CH
Tseng
Chien-An
CA
Sun
D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid