Haplotype inference.
The information carried by combination of alleles on the same chromosome, called haplotypes, is of crucial interest in several fields of modern genetics as population genetics or association studies. However, this information is usually lost by sequencing and needs, therefore, to be recovered by inference. In this chapter, we give a brief overview on the methods able to tackle this problem and some practical concerns to apply them on real data.
Chaire de Bioinformatique, Conservatoire National des Arts et Métiers, Paris, France.
Olivier
O
Delaneau
Jean-François
JF
Zagury
D000465:Algorithms; D000483:Alleles; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D056426:Genetic Loci; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide