[Thymic carcinoid associated with multiple endocrine neoplasia type 1].
We report a case of a thymic carcinoid associated with multiple endocrine neoplasia type 1( MEN-1). A 37-year-old man was referred to our hospital for further examination of an abnormal chest shadow. A chest computed tomography (CT) showed an anterior mediastinal mass measuring 6.5 cm in diameter. A pathological diagnosis of thymic carcinoid was made from a CT-guided needle biopsy specimen. Preoperative workup including endocrinological examination revealed a pituitary adenoma and hyperparathyroidism, and MEN-1 was clinically diagnosed. We performed total parathyroidectomy with autotransplantation and thymectomy with lymph node dissection through cervical collar incision and median sternotomy. The diagnosis of MEN-1 was confirmed by the genomic analysis postoperatively. Since 25% of thymic carcinoids are MEN-1 related and 95% of MEN-1 patients develop hyperparathyroidism, it should be kept in mind that this condition can be treated by thymectomy and concurrent parathyroidectomy.
Department of Thoracic Surgery, Iwate Prefectural Central Hospital, Morioka, Japan.
Itaru
I
Ishida
Hiroyuki
H
Oura
Hiromichi
H
Niikawa
Ken
K
Onodera
Masashi
M
Handa
Koji
K
Onuki
Minoru
M
Kawamura
D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000601:surgery; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000601:surgery*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000601:surgery; D016105:Parathyroidectomy; D013934:Thymectomy; D013953:Thymus Neoplasms / Q000150:complications* / Q000601:surgery