Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative.
It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407 nm) and green (500-550 nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching.
Dept. of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
Subhas
S
Samanta
Chuanguang
C
Qin
Alan J
AJ
Lough
G Andrew
GA
Woolley
D001391:Azo Compounds / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D055668:Photochemical Processes; D017434:Protein Structure, Tertiary
D001391:Azo Compounds; D010455:Peptides; C009850:azobenzene