Clinical and histopathologic parameters in survival of oral squamous cell carcinoma.
OBJECTIVE
The aim of this study was to assess the relevance of clinical and histopathologic parameters on survival of oral squamous cell carcinoma (OSCC) patients in Sri Lanka.


METHODS
A cohort of 193 previously diagnosed OSCC patients were followed for up to 5 years. Clinical and histopathologic parameters were analyzed regarding local recurrence and 5-year survival after treatment.


RESULTS
Site, stage, local recurrence, degree of differentiation, degree of keratinization, pattern of invasion, and status of the excision margins showed a significant association with the 5-year survival (P < .05). Multivariate analysis identified stage, pattern of invasion, and status of the excision margins as true independent prognostic indicators of OSCC. Pattern of invasion was the best prognosticator of both local recurrence and overall survival in the Cox regression model (P < .001).


CONCLUSIONS
Stage, pattern of invasion, and status of the excision margins are superior prognostic indicators of OSCC compared with other parameters.
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
Waruna Lakmal
WL
Dissanayaka
Gayani
G
Pitiyage
Pallegoda Vithanage Ranjith
PV
Kumarasiri
Rubasinha Liyanage Pemith Ranura
RL
Liyanage
Kumara Dayanath
KD
Dias
Wanninayake Mudiyanselage
WM
Tilakaratne
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009333:Neck; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013188:Sri Lanka / Q000453:epidemiology; D015996:Survival Rate