Chronic disfiguring facial lesions in an immunocompetent patient due to Exophiala spinifera: a case report and review of literature.
Exophiala spinifera is a rare fungus causing chromoblastomycosis or different types of phaeohyphomycosis (cutaneous, subcutaneous, disseminated and cyst phaeohyphomycosis). We report a case of a young male with phaeohyphomycosis due to E. spinifera, who had multiple itchy painful papular lesions disfiguring his face for 4 years. His diagnosis was delayed and had received antibacterial and antileishmanial therapy elsewhere without any improvement. While he reported to our hospital, the histopathology of the biopsy collected from the lesion demonstrated acute on chronic inflammation with granuloma formation and darkly pigmented fungal elements. The isolate grown on culture was identified as E. spinifera on the basis of morphological characters. The identification of the isolate was further confirmed by sequencing of the ITS region of ribosomal DNA. After treatment with oral itraconazole, he had marked clinical improvement.
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research-PGIMER, Chandigarh 160012, India.
Gagandeep
G
Singh
M R
MR
Shivaprakash
Dipankar
D
De
Prerna
P
Gupta
Sunita
S
Gupta
A J
AJ
Kanwar
Arunaloke
A
Chakrabarti
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D002862:Chromoblastomycosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D005093:Exophiala / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D005145:Face / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male
D000935:Antifungal Agents