Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.
Introduction of a novel influenza virus into the human population leads to the occurrence of pandemic events, such as the one caused by pandemic influenza A (H1N1) 2009 virus. The severity of infections caused by this virus in young adults was greater than that observed in patients with seasonal influenza. Fatal cases have been associated with an abnormal innate, proinflammatory immune response. A critical role for natural killer cells during the initial responses to influenza infections has been suggested. In this study, we assessed the association of killer-cell immunoglobulin-like receptors (KIRs) with disease severity by comparing KIR gene content in patients with mild and severe pandemic influenza virus infections to a control group. We found that activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes, encoded in group B haplotypes containing the cB01, cB03 and tB01 motifs, are associated with severe pandemic influenza A (H1N1) 2009 infections. Better understanding of how genetic variability contributes to influenza virus pathogenesis may help to the development of immune intervention strategies aiming at controlling the severity of disease.
Departamento de Microbiología, Universidad Autónoma de San Luis Potosí, Avenida Venustiano Carranza #2405, Colonia los Filtros, 78210 San Luis Potosí, Mexico.
Saray
S
Aranda-Romo
Christian A
CA
Garcia-Sepulveda
Andreu
A
Comas-García
Fernando
F
Lovato-Salas
Mariana
M
Salgado-Bustamante
Alejandro
A
Gómez-Gómez
Daniel E
DE
Noyola
D000293:Adolescent; D000328:Adult; D000368:Aged; D020816:Amino Acid Motifs; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D058873:Pandemics; D020033:Protein Isoforms / Q000235:genetics; D054340:Receptors, KIR / Q000235:genetics*; D054346:Receptors, KIR2DL5 / Q000235:genetics*; D054349:Receptors, KIR3DS1 / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
C531595:KIR2DS5 protein, human; D020033:Protein Isoforms; D054340:Receptors, KIR; D054346:Receptors, KIR2DL5; D054349:Receptors, KIR3DS1