[Pleomorphic fibrosarcoma].
263 tumors diagnosed as malignant fibrous histiocytomas and undifferentiated pleomorphic sarcomas have been reassessed morphologically, immunohistochemically and ultrastructurally. The diagnosis of pleomorphic fibrosarcoma was made in 19 patients (5%). The tumors occur in the lower and upper extremities and trunk. The patients have a long history of painless intramuscular mass (for a median of 6 months). Follow up showed disease recurrence in 24% of patients and metastases in 32% of patients. All tumors consisted of spindle-shaped fibroblasts and myofibroblasts with a prominent rough endoplasmic reticulum and Golgi apparatus, extracellular collagen fibrils. Variable number of histiocite-like fibroblasts and undifferentiated cells were found. No other signs of tumor cell line differentiation were noted. A pleomorphic fibrosarcoma and malignant fibrous histiocytoma have similar clinical and radiographic manifestation and survival rates.
O P
OP
Blizniukov
Ia A
IaA
Zamogil'naia
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D005354:Fibrosarcoma / Q000737:chemistry / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D058628:Myofibroblasts / Q000473:pathology; D010146:Pain / Q000209:etiology; D011859:Radiography; D012189:Retrospective Studies