Topography of maturational changes in EEG burst spectral power of the preterm infant with a normal follow-up at 2 years of age.
OBJECTIVE
To quantify the electroencephalography (EEG) burst frequency spectrum of preterm infants by automated analysis and to describe the topography of maturational change in spectral parameters.


METHODS
Eighteen preterm infants <32weeks gestation and normal neurological follow-up at 2years underwent weekly 4-h EEG recordings (10-20 system). The recordings (n=77) represent a large variability in postmenstrual age (PMA, 28-36weeks). We applied an automated burst detection algorithm and performed spectral analysis. The frequency spectrum was divided into δ1 (0.5-1Hz), δ2 (1-4Hz), θ (4-8Hz), α (8-13Hz) and β (13-30Hz) bands. Spectral parameters were evaluated as a function of PMA by regression analysis. Results were interpolated and topographically visualised.


RESULTS
The majority of spectral parameters show significant change with PMA. Highest correlation is found for δ and θ band. Absolute band powers decrease with increasing PMA, while relative α and β powers increase. Maturational change is largest in frontal and temporal region.


CONCLUSIONS
Topographic distribution of maturational changes in spectral parameters corresponds with studies showing ongoing gyration and postnatal white matter maturation in frontal and temporal lobes.


CONCLUSIONS
Computer analysis of EEG may allow objective and reproducible analysis for long-term prognosis and/or stratification of clinical treatment.
Máxima Medical Centre, Department of Clinical Physics, Veldhoven, The Netherlands.
Ward
W
Jennekens
Hendrik J
HJ
Niemarkt
Marjolein
M
Engels
Jaco W
JW
Pasman
Carola
C
van Pul
Peter
P
Andriessen
D000465:Algorithms; D001921:Brain / Q000254:growth & development* / Q000502:physiology*; D001931:Brain Mapping; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000254:growth & development / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D007234:Infant, Premature / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D013057:Spectrum Analysis; D013702:Temporal Lobe / Q000254:growth & development / Q000502:physiology