Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention.
BACKGROUND
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury.


OBJECTIVE
To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).


METHODS
Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI.


RESULTS
Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels.


CONCLUSIONS
The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.
Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Department of Cardiology, Beijing, China.
Shaomin
S
Chen
Lijun
L
Guo
Ming
M
Cui
Lijie
L
Sun
Lin
L
Mi
D000368:Aged; D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D020107:Troponin T