Lack of association between serum uric acid levels and outcome in acute ischemic stroke.
BACKGROUND
The prognostic value of serum uric acid (UA) in acute ischemic stroke is controversial. The aim of this study is to further analyse the relation between UA and outcome after acute ischemic stroke.


METHODS
We analysed UA levels in blood samples collected within 6h of stroke onset from patients included in the placebo arm of the US and Canadian Lubeluzole Ischemic Stroke Study (LUB-INT-9). We compared mean serum UA levels in patients with and without early neurological improvement (≥ 4 versus <4 points improvement on NIHSS after 5 days) and in patients with good functional and poor functional outcome (mRS 0-2 versus mRS 3-6). Multivariable logistic regression analyses were performed to adjust for possible confounders.


RESULTS
UA levels of 226 patients were available for analysis. Mean serum UA levels were not significantly higher in patients with than without early neurological improvement (0.33 mmol/L versus 0.30 mmol/L, p=0.070). The difference between patients with good and patients with poor functional outcome was borderline statistically significant (0.34 mmol/L versus 0.31 mmol/L, p=0.050). After adjustment for confounders, higher serum UA levels were neither associated with early neurological improvement OR (1.30, 95% CI 0.98-1.73, p=0.069), nor with a good functional outcome (OR 1.09, 95% CI 0.72-1.65, p=0.690).


CONCLUSIONS
We found no association between admission serum UA levels and both short- and long-term outcome in acute ischemic stroke.
Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands. i.miedema@neuro.umcg.nl
Irene
I
Miedema
Maarten
M
Uyttenboogaart
Marcus
M
Koch
Berry
B
Kremer
Jacques
J
de Keyser
Gert-Jan
GJ
Luijckx
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology*; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid