Overweight and obesity are increased in childhood-onset cerebrovascular disease.
The objective of this work was to determine whether overweight/obesity is a risk factor for cerebrovascular disease in children. The study included 53 children with non-neonatal-onset cerebral sinovenous thrombosis or arterial ischemic stroke. The prevalence of overweight/obesity was compared between this cohort and healthy children from the National Health and Nutrition Examination Survey. In addition, cerebral sinovenous thrombosis patients were compared to a group of matched hospitalized controls. The prevalence of overweight/obesity was significantly higher in the cerebral sinovenous thrombosis cohort (55%), but not the arterial ischemic stroke cohort (36%), relative to national controls (32%; P = .04 and P = .81, respectively). Similarly, the prevalence of overweight/obesity was significantly higher in the cerebral sinovenous thrombosis cohort than in Colorado controls (25%; P = .02). In conclusion, the prevalence of overweight/obese was significantly increased in cerebral sinovenous thrombosis patients as compared to both national and local controls. Results should be evaluated in a larger multi-institutional cohort.
School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. timothy.bernard@ucdenver.edu
Virginia
V
Pearson
Chris
C
Ruzas
Nancy F
NF
Krebs
Neil A
NA
Goldenberg
Marilyn J
MJ
Manco-Johnson
Timothy J
TJ
Bernard
D000293:Adolescent; D002561:Cerebrovascular Disorders / Q000150:complications / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors