[Bioinformatic research of the family of PEX11, peroxisome proliferous factor in fungus].
The family members of PEX11 are key factors involved in regulation of peroxisome proliferation. Sixty-six PEX11p candidates of PEX11 gene family from 26 representative fungal species were obtained and analyzed by bioinformatic strategies. In most filamentous fungi, 2 or 3 potential PEX11ps were found, in contrast with 1 or 2 in yeast species. Compared with other fungal species, the Ascomycetes tend to have more PEX11ps, and even 5 in several individuals. The data of phylogenetic analysis and protein structure indicated that all of the PEX11ps were divided into 3 groups: I, II, and III. The members of group I and group III existed in most species, while those in group II were found only in Pezizomycotina. By MEME analysis, 5-6 conserved motifs were found in each PEX11ps. Among them,motif 8 in C-terminal had the most conservation, indicating that this motif probably plays a key role in maintaining the proper function of PEX11p.
College of Life and Environment Sciences, Hangzhou Normal University, Hangzhou 310036, China. aaazxaaa@qq.com
Xin
X
Zhang
Hua
H
Jiang
Yan-Li
YL
Wang
Zhen
Z
Zhang
Xue-Qin
XQ
Mao
Rong-Yao
RY
Chai
Hai-Ping
HP
Qiu
Xin-Fa
XF
Du
Jiao-Yu
JY
Wang
Guo-Chang
GC
Sun
D000595:Amino Acid Sequence; D049109:Cell Proliferation; D019295:Computational Biology; D005656:Fungal Proteins / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D000074401:Peroxins; D020675:Peroxisomes / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D005656:Fungal Proteins; D008565:Membrane Proteins; C092128:PEX11 protein, S cerevisiae; D000074401:Peroxins; D029701:Saccharomyces cerevisiae Proteins