Autophagy and ageing: insights from invertebrate model organisms.
Ageing in diverse species ranging from yeast to humans is associated with the gradual, lifelong accumulation of molecular and cellular damage. Autophagy, a conserved lysosomal, self-destructive process involved in protein and organelle degradation, plays an essential role in both cellular and whole-animal homeostasis. Accumulating evidence now indicates that autophagic degradation declines with age and this gradual reduction of autophagy might have a causative role in the functional deterioration of biological systems during ageing. Indeed, loss of autophagy gene function significantly influences longevity. Moreover, genetic or pharmacological manipulations that extend lifespan in model organisms often activate autophagy. Interestingly, conserved signalling pathways and environmental factors that regulate ageing, such as the insulin/IGF-1 signalling pathway and oxidative stress response pathways converge on autophagy. In this article, we survey recent findings in invertebrates that contribute to advance our understanding of the molecular links between autophagy and the regulation of ageing. In addition, we consider related mechanisms in other organisms and discuss their similarities and idiosyncratic features in a comparative manner.
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Crete, Greece.
Eirini
E
Lionaki
Maria
M
Markaki
Nektarios
N
Tavernarakis
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D004777:Environment; D006801:Humans; D007448:Invertebrates / Q000502:physiology*; D008136:Longevity / Q000187:drug effects; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological