Effect of sodium fluoride, ampicillin, and chlorhexidine on Streptococcus mutans biofilm detachment.
We examined the effect of three clinically used antimicrobials on Streptococcus mutans UA159 biofilm detachment under flow conditions. Sodium fluoride (NaF) and chlorhexidine at MIC levels promoted biofilm detachment and inhibited detachment when concentrations were higher than the MIC and reduced detached-cell viability only at high concentrations. Ampicillin at all concentrations tested inhibited detachment and reduced the percentage of viable biofilm-detached cells. All the three antimicrobial treatments reduced biofilm live/dead cell ratios.
Institute of Stomatological Research, Guanghua School of Stomotology, Sun Yat-sen University, Guangzhou, China.
Jia
J
Liu
Jun-Qi
JQ
Ling
Kai
K
Zhang
Li-Jun
LJ
Huo
Yang
Y
Ning
D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002327:Cariostatic Agents / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012969:Sodium Fluoride / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D000667:Ampicillin; D012969:Sodium Fluoride; D002710:Chlorhexidine