[T-lymphocyte subpopulations and immune response in mice of the ASC strain with depressive-like behaviour].
Analysis of the content of CD16/32+, CD4+ and CD8+ -cells was perfomed in the peripheral blood and spleen ofmice of the ASC strain with high predisposition to depressive-like state in comparison with mice of parent CBA strain having no depressive behaviour. In both cases, ASC mice showed a decrease in the percentage of CD16/32+ and CD4+-cells along with an increase CD8 cells and lowering of immunoreactivity index (CD4+/CD8+). Changes in cellular subpopulations found in intact ASC mice was accompanied with animals' low capacity to respond to T-dependent antigen: sheep red blood cells at the dose of 5 x 10(8). In contrast to CBA mice the percentage and absolute number of IgM-antibody-forming cells were significantly decreased in the spleen of ASC mice on the 4th and 5th days after immunization as well as the numbers of IgG-antibody-forming cells on the 6th day of the immune response. Possible mechanisms underlying the immune reactivity inhibition under depressive-like state are discussed.
G V
GV
Idova
E L
EL
Al'perina
M M
MM
Gevorgian
E N
EN
Zhukova
A V
AV
Kulikov
D V
DV
Iur'ev
D000818:Animals; D000957:Antigens, Viral, Tumor; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003863:Depression / Q000276:immunology* / Q000473:pathology; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D013154:Spleen / Q000276:immunology
D000957:Antigens, Viral, Tumor; D007074:Immunoglobulin G; D007075:Immunoglobulin M