Found in translation of mTOR signaling.
The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
John G
JG
Clohessy
Markus
M
Reschke
Pier Paolo
PP
Pandolfi
D000818:Animals; D015536:Down-Regulation / Q000187:drug effects; D039642:Eukaryotic Initiation Factors / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D009287:Naphthyridines / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
C553294:1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one; D039642:Eukaryotic Initiation Factors; D007211:Indoles; D009287:Naphthyridines; D047428:Protein Kinase Inhibitors; D011687:Purines; D012333:RNA, Messenger; D058570:TOR Serine-Threonine Kinases; C572919:PP242