Role of neuroactive steroids in the peripheral nervous system.
Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system. In the present review we summarize observations indicating that synthesis and metabolism of neuroactive steroids also occur in the peripheral nerves. Interestingly, peripheral nervous system is also a target of their action. Indeed, as here reported neuroactive steroids are physiological regulators of peripheral nerve functions and they may also represent interesting therapeutic tools for different types of peripheral neuropathy.
Department of Endocrinology, Pathophysiology and Applied Biology - Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano Milano, Italy.
Roberto Cosimo
RC
Melcangi
Silvia
S
Giatti
Marzia
M
Pesaresi
Donato
D
Calabrese
Nico
N
Mitro
Donatella
D
Caruso
Luis Miguel
LM
Garcia-Segura