The coalescence of intrahost HIV lineages under symmetric CTL attack.
Cytotoxic T lymphocytes (CTLs) are immune system cells that are thought to play an important role in controlling HIV infection. We develop a stochastic ODE model of HIV-CTL interaction that extends current deterministic ODE models. Based on this stochastic model, we consider the effect of CTL attack on intrahost HIV lineages assuming that CTLs attack several epitopes with equal strength. In this setting, we introduce a limiting version of our stochastic ODE under which we show that the coalescence of HIV lineages can be described through Poisson-Dirichlet distributions. Through numerical experiments, we show that our results under the limiting stochastic ODE accurately reflect HIV lineages under CTL attack when the HIV population size is on the low end of its hypothesized range. Current techniques of HIV lineage construction depend on the Kingman coalescent. Our results give an explicit connection between CTL attack and HIV lineages.
Department of Mathematics, Georgetown University, Washington, DC, USA. sr286@georgetown.edu
Sivan
S
Leviyang
D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006678:HIV / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008957:Models, Genetic; D018448:Models, Immunological; D013269:Stochastic Processes; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes