Use of daptomycin for the treatment of methicillin-resistant coagulase-negative staphylococcal ventriculitis.
Coagulase-negative staphylococci (CoNS) are the main pathogens causing hospital-acquired external-ventricular-drain- (EVD-) and lumbar-drain- (LD-) associated meningitis and ventriculitis. The treatment of these infections can be challenging and may require combination of intraventricular and intravenous administration of antibiotics. Limited animal data demonstrate rapid daptomycin bactericidal activity, adequate penetration in the setting of inflamed meninges, and extended half-life in the ventricles Steenbergen et al. (2009). There are limited clinical data using daptomycin intravenously and/or intraventricularly for the treatment of central nervous system infections (CNS) Elvy et al. (2008), Stucki et al. (2007), Lee et al. (2008) and Wallace et al. (2009). We report here our experience in the treatment of an EVD-related infection.
Division of Infectious Diseases, Department of Medicine, New York Hospital Queens, Flushing, NY 11355, USA.
Mohamed
M
Erritouni
Nessrine
N
Ktaich
James J
JJ
Rahal
Deborah
D
Figueroa
Jaime
J
Nieto
Carl
C
Urban
Noriel
N
Mariano
Frank
F
Eisinger
Jonathan
J
Abayev
David
D
Nicolau
David
D
Rubin
Murisiku
M
Raifu
Sorana
S
Segal-Maurer