Synthesis, characterization, and evaluation of five coordinated copper(II) complexes as antibacterial, artificial nuclease, and SOD mimics.
The copper(II) complexes with ciprofloxacin (CFLH), levofloxacin (LFLH), norfloxacin (NFLH), and neutral bidentate ligands have been synthesized and characterized. The complexes have been evaluated for their antibacterial activity against selective species. Complexes have been also checked for their interacting behavior with DNA, and were found to have two different modes of interaction, classical and partial intercalation. Tested complexes were found to be better antioxidants with their IC(50) values ranging from 0.51 to 0.97 μM.
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenen@gmail.com
M N
MN
Patel
D S
DS
Gandhi
P A
PA
Parmar
D000042:Absorption; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism*; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D014783:Viscosity
D000900:Anti-Bacterial Agents; D008024:Ligands; D009942:Organometallic Compounds; D003300:Copper; D004247:DNA; D013482:Superoxide Dismutase; D003851:Deoxyribonucleases