Urinary diversion via cutaneous vesicostomy in the megabladder mouse.
Lower urinary tract obstruction in mice can lead to end-stage renal disease and death. We have developed a surgical technique to create a cutaneous vesicostomy in mice providing an external outlet for drainage of urine, thereby relieving the obstruction and slowing and/or preventing the development of end-stage renal disease and death.
Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Ashley.Carpenter@nationwidechildrens.org
Ashley R
AR
Carpenter
Brian
B
Becknell
Daniel A
DA
Hirselj
Kirk M
KM
McHugh
D000818:Animals; D003559:Cystostomy / Q000379:methods*; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D008297:Male; D051379:Mice; D014517:Ureteral Obstruction / Q000601:surgery*; D001743:Urinary Bladder / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*