Nonlinear dynamics of heart rate variability in response to orthostatism and hemodialysis in chronic renal failure patients: recurrence analysis approach.
We studied the response of heart rate variability to hemodialysis and orthostatism using traditional linear indexes and 9 recurrence quantification analysis indexes to reveal changes in the heart rate dynamics. Twenty healthy subjects and 19 chronic renal failure patients treated with hemodialysis thrice a week were included. Five-minute heart rate variability time series were obtained during supine position (clinostatism) and orthostatism from each participant; recordings in renal patients were repeated after hemodialysis. Linear indexes were consistent with sympathetic predominance in response to orthostatism in the control group. Renal patients before hemodialysis showed increased sympathetic predominance in clinostatism, with further increase in orthostatism and hemodialysis. In response to orthostatism, 4 recurrence indexes changed in the control group, while in renal patients any of them changed before hemodialysis and 1 changed after hemodialysis. In clinostatism, renal patients (both before and after hemodialysis) had higher laminarity, trapping time, and recurrence time than the control group. Recurrence indexes showed that the heart rate dynamics in renal patients are different from healthy subjects, suggesting loss of access to some regulatory conditions. These findings are consistent with reports of sympathetic stimulation induced by hemodialysis and active standing.
Laboratorio de Biofísica de Sistemas Excitables, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico.
Hortensia
H
González
Oscar
O
Infante
Héctor
H
Pérez-Grovas
Marco V
MV
Jose
Claudia
C
Lerma
D000328:Adult; D016022:Case-Control Studies; D004562:Electrocardiography / Q000379:methods*; D006339:Heart Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D017711:Nonlinear Dynamics; D011187:Posture; D012008:Recurrence; D006435:Renal Dialysis; D013997:Time Factors; D055815:Young Adult