How do we collect better granulocyte?
We studied retrospectively the factors affecting the product quality in 459 donor granulocyte apheresis procedures from 420 donors for 71 neutropenic patients from 2004 to 2010 in a single center. The counts of the granulocyte and platelet collected were measured to evaluate the product quality. The data was analyzed to determine a possible relationship between product quality and several parameters including gender, preleukapheresis neutrophil count, type of anticoagulation and separator type and mode of the apheresis system. We found that collection of better granulocyte is possible from a donor in a single procedure by changing anticoagulation type and separator mode during apheresis.
Hacettepe University Hospital, Blood Center and Apheresis Unit, F-06100 Altındağ-Ankara, Turkey. drtulaykaraagac@yahoo.com
Tülay Karaağaç
TK
Akyol
Yahya
Y
Büyükaşık
Salih
S
Aksu
Osman İlhami
Oİ
Ozcebe
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000628:therapy*; D012189:Retrospective Studies