Construction and performance characteristics of new ion selective electrodes based on carbon nanotubes for determination of meclofenoxate hydrochloride.
This work offers construction and comparative evaluation the performance characteristics of conventional polymer (I), carbon paste (II) and carbon nanotubes chemically modified carbon paste ion selective electrodes (III) for meclofenoxate hydrochloride are described. These electrodes depend mainly on the incorporation of the ion pair of meclofenoxate hydrochloride with phosphomolybdic acid (PMA) or phosphotungestic acid (PTA). They showed near Nernestian responses over usable concentration range 1.0 × 10(-5) to 1.0 × 10(-2)M with slopes in the range 55.15-59.74 mV(concentrationdecade)(-1). These developed electrodes were fully characterized in terms of their composition, response time, working concentration range, life span, usable pH and temperature range. The electrodes showed a very good selectivity for Meclo with respect to a large number of inorganic cations, sugars and in the presence of the degradation product of the drug (p-chloro phenoxy acetic acid). The standard additions method was applied to the determination of MecloCl in pure solution, pharmaceutical preparations and biological samples. Dissolution testing was also applied using the proposed sensors.
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt. rasha.elnashar@guc.edu.eg
Rasha M
RM
El-Nashar
Nour T
NT
Abdel Ghani
Sherif M
SM
Hassan
D002244:Carbon / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D002504:Meclofenoxate / Q000032:analysis* / Q000097:blood / Q000652:urine; D008982:Molybdenum / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D010772:Phosphotungstic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011199:Potentiometry; D012680:Sensitivity and Specificity
D037742:Nanotubes, Carbon; D010756:Phosphoric Acids; D011108:Polymers; D010772:Phosphotungstic Acid; D002244:Carbon; D008982:Molybdenum; D002504:Meclofenoxate; C003125:phosphomolybdic acid