Assessment of relative brain-skull motion in quasistatic circumstances by magnetic resonance imaging.
Brain-skull relative motion plays a pivotal role in the etiology of traumatic brain injury (TBI). The present study aims to assess brain-skull relative motion in quasistatic circumstances, and to correlate cortical regions with high motion amplitudes with sites prone to cerebral contusions. The study includes 30 healthy volunteers scanned using a clinical 3-T MR scanner in four different head positions. Through image processing and 3D model registration, pairwise comparisons were performed to calculate the brain shift between sagittal and coronal head positional change. Next, local brain deformation was evaluated by comparison between cortical and ventricular amplitudes. Finally, the influence of age, sex, and skull geometry on the cortical and ventricular motion was investigated. The results describe complex brain shift patterns, with high regional and inter-individual variations, outweighing age and sex patterns. Regions with maximum motion amplitudes were identified at the inferolateral aspects of the frontal and temporal lobes, congruent with predilection sites for contusions. No significant influences of age and sex on the cortical shift amplitudes were detected. The 3D cortical deviations varied from -7.86 mm to +5.71 mm for the sagittal head movement, and from -11.46 mm to +7.30 mm for head movement in the coronal plane, for a 95% confidence interval. The present study contributes to a better understanding of the mechanopathogenesis of frontotemporal contusions, and is useful for the optimization of finite-element head models and neurosurgical navigation procedures. Moreover, our results prove that in vivo MRI allows for accurate assessment of brain-skull relative motion in quasistatic conditions.
Division of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, Celestijnenlaan 300, Box 2419, 3001 Heverlee, Belgium. aidageorgeta.asiminei@med.kuleuven.be
Aida Georgeta
AG
Monea
Ignaas
I
Verpoest
Jos
J
Vander Sloten
Georges
G
Van der Perre
Jan
J
Goffin
Bart
B
Depreitere
D000293:Adolescent; D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D019416:Head Movements / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D012886:Skull / Q000033:anatomy & histology / Q000502:physiology*; D055815:Young Adult