Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature.
We report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner's syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilateral prophylactic oophorectomy to the patient. One year later the patient presented with abdominal mass, biopsy of the specimen following resection confirmed dysgerminoma originating from right ovary with no invasion or metastasis. The literature is reviewed with regard to the various pathogenetic mechanisms proposed for the development of germ cell tumors in ovary, the cytogenetic findings and recommendations to handle such scenario.
Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.
Sunil Kumar
SK
Kota
Kotni
K
Gayatri
Jaya Prakash
JP
Pani
Siva Krishna
SK
Kota
Lalit Kumar
LK
Meher
Kirtikumar D
KD
Modi