Conjugated linoleic acid in the maternal diet differentially enhances growth and cortical spreading depression in the rat progeny.
BACKGROUND
Conjugated linoleic acids (CLA) are fatty acids that are found in the lipids from goat milk, and appear to protect neurons from excitotoxicity.


METHODS
We investigated in developing rats the effects of a maternal CLA-rich diet (containing 7% lipids from goat milk) on body development and cerebral electrical activity of the progeny from dams receiving the CLA diet during gestation (G), lactation (L) or both periods (G+L).


RESULTS
Compared to a control group (C) receiving a diet with 7% soybean oil, body weight increased at 14, 21 and 28 days, but not at 35-45 days, in L and G+L groups (P<0.05). No intergroup difference was found on body and brain weights, body length, abdominal and thoracic circumferences, body mass index and abdominal to thoracic circumference ratio at 35-45 days. In contrast, at this later age the CSD velocities of propagation were significantly higher (P<0.05) in L as compared with the C and G group, and in the L+G, as compared with the C, G and L groups, suggesting a long-lasting brain effect.


CONCLUSIONS
These data indicate that a maternal CLA-rich diet can differentially influence body weight increment (short-term effect), and CSD propagation (long-term effect) in the progeny, and the lactation is the most critical period for such diet actions.


CONCLUSIONS
The facilitating effect of the lipids from goat milk on an excitability-related phenomenon in the brain (CSD) can be of clinical relevance, since CSD has been associated to neurological disturbances like migraine and epilepsy.
Laboratório de Fisiologia da Nutrição Naíde Teodósio, Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Juliana K B
JK
Soares
Ana P
AP
Rocha-de-Melo
Maria C
MC
Medeiros
Rita C R E
RC
Queiroga
Marco A D
MA
Bomfim
Amanda F O
AF
de Souza
Ana L V
AL
Nascimento
Rubem C A
RC
Guedes
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D013181:Cortical Spreading Depression / Q000187:drug effects*; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D005260:Female; D006128:Growth / Q000187:drug effects*; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated