BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke.
Genetic factors might be involved in stroke prognosis, however the role of brain-derived neurotrophic factor (BDNF) in stroke recovery is unknown. We have studied BDNF -196 G>A and -270 C>T polymorphisms in ischemic and hemorrhagic stroke and their impact on stroke prognosis. There was higher occurrence of BDNF -270 CC genotype in patients with hemorrhagic than ischemic stroke (96% versus 86%, p=0.0495). In hemorrhagic stroke BDNF -196 GG carriers scored better in NIHSS at admission (14.23 versus 21.00, p=0.0192) and after 7days (8.60 versus 15.00, p=0.0408) of onsets. None of the determined polymorphisms had any impact on 30-day early outcome in ischemic and hemorrhagic stroke.
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland.
Dagmara
D
Mirowska-Guzel
Grazyna
G
Gromadzka
Andrzej
A
Czlonkowski
Anna
A
Czlonkowska
D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D020127:Recovery of Function / Q000235:genetics*; D020521:Stroke / Q000209:etiology / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor