Copper-catalyzed arylation of o-bromoanilides: highly flexible synthesis of hexahydropyrroloindole alkaloids.
In the presence of catalytic amount of copper iodide, a remote amide-assisted intramolecular arylation followed by alkylation leads to a general and flexible synthetic method toward the synthesis of medicinally interesting hexahydropyrroloindole alkaloids.
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Yongyun
Y
Zhou
Yongkai
Y
Xi
Jingfeng
J
Zhao
Xianfu
X
Sheng
Shuqin
S
Zhang
Hongbin
H
Zhang
D000470:Alkaloids / Q000138:chemical synthesis*; D000478:Alkylation; D000813:Anilides / Q000737:chemistry*; D017605:Bromine Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006900:Hydroxylation; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
D000470:Alkaloids; D000813:Anilides; D017605:Bromine Compounds; D007211:Indoles; D011758:Pyrroles; D003300:Copper; C030374:indole