Role of prophylactic antibiotic in elective laparoscopic cholecystectomy.
This prospective study was conducted to investigate the efficacy of single-dose Ceftazidime as a prophylactic antibiotic to prevent surgical site infections in low-risk patients undergoing LC. Two hundred patients included in the study were randomly divided into two groups (100 each): G1: patients received intravenous Ceftazidime within 60 minutes prior to surgery and G2: received intravenous placebo (10 ml isotonic sodium chloride 0.9% solution). All patients were invited for examination 10, 20 and 30 days post-operatively and any post-operative complications were recorded and managed. Preoperatively; there was no significant differences existed between the 2 groups regarding sex, age; body mass index and ASA score. Also, the duration of LC surgery, incidence of intra-operative gallbladder perforations and spill of bile or stones, incidents of intra-operative bleeding from either cystic artery or gall bladder liver bed and mean postoperative hospital stay were found not significantly different between the 2 groups. Post operatively there was no statistical difference regarding the surgical site infection between the two groups.
Department of General Surgery, Theodor Bilharz Research Institute, Warak El-Hadar, Kornish El-Nile, Imbaba P.O. Box 30, Giza, 12411, Egypt. ahmedelmaghney@yahoo.com
Ahmed Mohamed Abdelaziz
AM
Hassan
Magid Mahmoud
MM
Nasr
Hosam Eldien
HE
Hamdy
Mohamed
M
Abbas
Mohammed Saied
MS
Hedaya
Magdy Mohamed
MM
Elsebae
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002442:Ceftazidime / Q000008:administration & dosage* / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control; D055815:Young Adult
D000900:Anti-Bacterial Agents; D002442:Ceftazidime