Successful salvage therapy of Fusarium endophthalmitis secondary to keratitis: an interventional case series.
OBJECTIVE
To describe a combination of treatment modalities used for the successful eradication of Fusarium endophthalmitis.


METHODS
Interventional case series.


METHODS
Three consecutive patients with keratitis-associated Fusarium endophthalmitis.


METHODS
After failure of traditional management options, a combination of intravitreal and long-term, high-dose systemic voriconazole, topical antifungal medications, and surgical intervention, with penetrating keratoplasty, lensectomy, and endoscopic-guided pars plana vitrectomy, was administered to each patient.


RESULTS
All three cases achieved full resolution of the infection, with a final Snellen visual acuity score of 20/50 to 20/70.


CONCLUSIONS
An aggressive combination of therapeutic modalities, including the removal of subiris abscesses, might be needed for the successful resolution of Fusarium endophthalmitis.
University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
Grant M
GM
Comer
Maxwell S
MS
Stem
Stephen J
SJ
Saxe