Association between obesity and gallbladder cancer.
Obesity has become a global health issue because of its increased morbidity and mortality, and a close association with at least 20 different cancers. Clinical and epidemiological studies have suggested that obesity and overweight are positively related with the risk of GBC. Gallbladder cancer (GBC) is a relatively infrequent but highly lethal neoplasm. Obesity may disturb lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and thus plays a role in GBC. Control of obesity through measures such as lifestyle modification, healthy diet, and regular exercise may prove useful in the prevention of GBC.
Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China. wangby@medmail.com.cn
Fei
F
Wang
Bingyuan
B
Wang
Liang
L
Qiao
D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000818:Animals; D005260:Female; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D042882:Gallstones / Q000150:complications; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D007333:Insulin Resistance; D008019:Life Style; D050356:Lipid Metabolism; D008297:Male; D008954:Models, Biological; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D012307:Risk Factors; D013002:Somatomedins / Q000378:metabolism
D054392:Adipokines; D012739:Gonadal Steroid Hormones; D013002:Somatomedins