A dual mechanism of action for skeletal muscle FAT/CD36 during exercise.
Carnitine palmitoyltransferase I has been viewed historically as the sole regulator of fatty acid oxidation. However, we have identified fatty acid translocase/CD36 as an additional control point. Specifically, fatty acid translocase/CD36 seems to have a novel dual mechanism of action with regard to fatty acid oxidation during exercise, influencing transport of lipids across the sarcolemmal membrane and into the mitochondria.
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Brennan K
BK
Smith
Arend
A
Bonen
Graham P
GP
Holloway
D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D012508:Sarcolemma / Q000378:metabolism*; D015854:Up-Regulation
D018955:CD36 Antigens