Traumatic ulcerative granuloma with stromal eosinophilia of the palate showing an angiocentric/angiodestructive growth pattern.
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign, self-limiting lesion of the oral mucosa with unknown pathogenesis. A 65-year-old male patient presented with an ulcerative palate lesion, which on microscopic examination exhibited an exuberant polymorphic lymphoid proliferation, numerous eosinophils, and extensive vascular destruction. The atypical lymphoid cells infiltrating the medium-sized vessels showed positivity for CD3, CD30, and granzyme B, implicating an activated cytotoxic T-cell phenotype. The lesion diagnosed as TUGSE achieved complete resolution within 3 months. This unusual presentation has expanded the spectrum of oral CD30+ T-cell atypical infiltrates and must be distinguished from lymphomas showing angiocentric/angiodestructive growth pattern.
Department of Oral Pathology, Dentistry School, Federal University of Sergipe, Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju-SE, Brazil.
Bernardo Ferreira
BF
Brasileiro
Daniel Berretta
DB
Alves
Bruno Augusto Benevenuto
BA
Andrade
Pablo Agustin
PA
Vargas
Jorge Esquiche
JE
León
Oslei Paes De
OP
Almeida