Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma.
We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non-Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1-3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9-2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4-0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5-1.0). A similar pattern was also observed for B-cell lymphoma but not for T-cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (P(forinteraction) = 0.003) and TNF (rs1800629) (P(forinteraction) = 0.012) for NHL overall and IL10RA (rs9610) (P(forinteraction) = 0.001) and TNF (rs1800629) (P(forinteraction) = 0.019) for B-cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk.
Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Xiaofeng
X
Bi
Tongzhang
T
Zheng
Qing
Q
Lan
Zhijian
Z
Xu
Yingtai
Y
Chen
Gongjian
G
Zhu
Francine
F
Foss
Christopher
C
Kim
Min
M
Dai
Ping
P
Zhao
Theodore
T
Holford
Brian
B
Leaderer
Peter
P
Boyle
Qian
Q
Deng
Stephen J
SJ
Chanock
Nathaniel
N
Rothman
Yawei
Y
Zhang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D006801:Humans; D053709:Interleukin-10 Receptor alpha Subunit / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D053709:Interleukin-10 Receptor alpha Subunit; D014409:Tumor Necrosis Factor-alpha