Chemoselective ligation of sulfinic acids with aryl-nitroso compounds.
Making a comeback: The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems.
Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
Mauro
M
Lo Conte
Kate S
KS
Carroll
D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*
D009603:Nitroso Compounds; D013441:Sulfinic Acids