Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: an overview.
The purpose of the present article is to review our actual knowledge on the desensitization of metabotropic glutamate receptors based on the literature available so far, with the attempt to emphasize all converging data and to give a possible explanation to those evidences that still remain controversial. 1. We review our knowledge on the regulation of mGlu receptors based on the available literature 2. We report converging data and we comment on issues that still remain controversial. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.
Dept. of Physiology and Pharmacology "V. Erspamer", University of Rome "Sapienza", P.le Aldo Moro 5, 00185 Rome, Italy. luisa.iacovelli@uniroma1.it
Luisa
L
Iacovelli
Ferdinando
F
Nicoletti
Antonio
A
De Blasi
D000818:Animals; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D048049:Extracellular Signal-Regulated MAP Kinases / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
D018094:Receptors, Metabotropic Glutamate; D000242:Cyclic AMP; D048049:Extracellular Signal-Regulated MAP Kinases