Whole-body retention and distribution of orally administered radiolabelled zerovalent iron nanoparticles in mice.
Zerovalent iron nanoparticles (nZVI) are used for in situ remediation of contaminated ground water, raising the possibility that nZVI particles or their altered residues could contaminate the ground water. Therefore, it is important to study their effects on humans and other organisms in vivo. The objective of this study was to assess the whole-body retention and terminal disposition of neutron-activated radioactive nZVI administered by oral gavage in mice. Radioactivity was primarily eliminated in the faeces within 1 day of administration. However, a small amount of iron-derived radioactivity appeared in the liver after three repeated daily doses. This prototypic study further suggests that neutron activation applied judiciously may be broadly applicable to studies of nanoparticles derived from other biologically abundant metals.
Divisions of Integrated Systems Toxicology and Toxicity Assessment, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, USA.
Michael F
MF
Hughes
Thomas C
TC
Long
William K
WK
Boyes
Ram
R
Ramabhadran
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000378:metabolism; D007501:Iron / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008643:Mesentery / Q000378:metabolism; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution
D007501:Iron