[Correction of a connective tissue dysplasia in the treatment of postoperative abdominal hernias].
There were analyzed the results of treatment of 112 patients, suffering postoperative abdominal hernia, in whom the anterior abdominal wall alloplasty was performed as well as postoperative pathogenetically substantiated complex therapy, taking into account the presence of a connective tissue dysplasia syndrome (CTDS) and the early and late postoperative complications prophylaxis. The peculiarities of postoperative period course and late follow-up results were studied up. Phenotypic features of CTDS were revealed in 53 (47.3%) patients, immunohistochemical features of a connective tissue dysplasia (a failed collagen type I and III ratio, manifested by increase of a collagen type III fibers quantity in 3 or more times) were revealed in 78 (69.6%) patients, in whom the processes of a collagen and its supermolecular formations synthesis were stimulated, using a magnesium orotate (Magnerot), which was prescribed in 1 g dose twice a day during 4 - 6 weeks. Application of composite nets, owing big pores, in a complex with a postoperative pathogenetically substantiated therapy conduction have positively influenced the disease course and the late follow-up results achieved.
S H
SH
Chetverikov
V Iu
VIu
Vododiuk
Iu V
IuV
Ier'omin
D M
DM
Osadchyĭ
D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery; D003094:Collagen / Q000819:agonists / Q000096:biosynthesis; D003238:Connective Tissue / Q000187:drug effects / Q000637:transplantation*; D005500:Follow-Up Studies; D046449:Hernia, Abdominal / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy* / Q000601:surgery; D011184:Postoperative Period; D013526:Surgical Mesh; D014184:Transplantation, Homologous
D009963:Orotic Acid; D003094:Collagen; C104468:magnesium orotate