Antioxidant effect of MnTE-2-PyP on lung in asthma mice model.
OBJECTIVE
To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.


METHODS
The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.


RESULTS
The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.


CONCLUSIONS
The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.
Sector of Clinical Immunology and Allergology, Pelven Medical University, 5800 Pleven, Bulgaria. luterzi@mail.bg
Lyudmil
L
Terziev
Violeta
V
Dancheva
Veneta
V
Shopova
Galya
G
Stavreva
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008665:Metalloporphyrins / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects
D000975:Antioxidants; D008665:Metalloporphyrins; C520506:manganese tetrakis-(N-ethyl-2 pyridyl) porphyrin