Clinical relevance of sHLA-G-mediated with better graft acceptance in early posttransplantation.
The aim of this study was to measure the level of soluble human leukocyte antigen (sHLA-G) in renal transplant patients, to determine the relationship between these levels and the occurrence of acute rejection episodes, and to identify their influence on graft acceptance early posttransplantation. sHLA-G, as measured by an enzyme-linked immunosorbent assay, was significantly increased (P < .01) early posttransplantation (3 months); the other group maintained low levels throughout the study. The latter group displayed a high incidence of acute rejection episodes and a lower clearance of serum creatinine with a longer period for hemoglobin to recover to normal (P < .01). These results suggested that HLA-G participates in the induction of immunologic tolerance in these recipients.
The Organ Transplant Center, the 309th Hospital of the Chinese PLA, Beijing, China.
H-L
HL
Jin
C-R
CR
Li
L
L
Xiao
B-Y
BY
Shi
M
M
Cai
Z-L
ZL
Li
S
S
Wang
L-P
LP
Chen
S-L
SL
Zhan
P-C
PC
Li
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002681:China; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D006085:Graft Survival; D059951:HLA-G Antigens / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism; D006648:Histocompatibility; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D023001:Transplantation Tolerance; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D059951:HLA-G Antigens; D006454:Hemoglobins; D007166:Immunosuppressive Agents; D003404:Creatinine