'Green'-synthesized near-infrared PbS quantum dots with silica-PEG dual-layer coating: ultrastable and biocompatible optical probes for in vivo animal imaging.
In this paper, PbS semiconductor quantum dots (QDs) with near-infrared (NIR) photoluminescence were synthesized in oleic acid and paraffin liquid mixture by using an easily handled and 'green' approach. Surface functionalization of the QDs was accomplished with a silica and polyethylene glycol (PEG) phospholipid dual-layer coating and the excellent chemical stability of the nanoparticles is demonstrated. We then successfully applied the ultrastable PbS QDs to in vivo sentinel lymph node (SLN) mapping of mice. Histological analyses were also carried out to ensure that the intravenously injected nanoparticles did not produce any toxicity to the organism of mice. These experimental results suggested that our ultrastable NIR PbS QDs can serve as biocompatible and efficient probes for in vivo optical bioimaging and has great potentials for disease diagnosis and clinical therapies in the future.
Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, Zhejiang University, Hangzhou 310058, People's Republic of China.
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D
Wang
J
J
Qian
F
F
Cai
S
S
He
S
S
Han
Y
Y
Mu
D000818:Animals; D004355:Drug Stability; D005456:Fluorescent Dyes; D055772:Green Chemistry Technology / Q000379:methods*; D006651:Histocytochemistry; D006801:Humans; D007854:Lead / Q000737:chemistry*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D019301:Oleic Acid; D010232:Paraffin; D019047:Phantoms, Imaging; D011092:Polyethylene Glycols / Q000737:chemistry*; D045663:Quantum Dots; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013440:Sulfides / Q000737:chemistry*
D005456:Fluorescent Dyes; D013440:Sulfides; C018391:lead sulfide; D007854:Lead; D019301:Oleic Acid; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D010232:Paraffin