Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury.
Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-κB independently of p53.
Bairbre A
BA
McNicholas
Matthew D
MD
Griffin
D058186:Acute Kidney Injury / Q000201:enzymology*; D000818:Animals; D007249:Inflammation / Q000201:enzymology*; D007684:Kidney Tubules / Q000201:enzymology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D015427:Reperfusion Injury / Q000201:enzymology*; D014945:Wound Healing
C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2