Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA.
Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.
Divisions of Rheumatology and Genetics, Department of Medicine, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Eli A
EA
Stahl
Soumya
S
Raychaudhuri
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D018450:Disease Progression; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006801:Humans; D011379:Prognosis; D019655:Quantitative Trait, Heritable; D012307:Risk Factors; D012720:Severity of Illness Index