Imprecise definitions of starting points in retrospectively reviewing potential organ donors causes confusion: call for a reproducible method like 'imminent brain death'.
Low donor supply and the high demand for transplantable organs is an international problem. The efficiency of organ procurement is often expressed by donor conversion rates (DCRs). These rates differ among countries, but a uniform starting point for defining a potential heart-beating donor is lacking. Imprecise definitions cause confusion; therefore, we call for a reproducible method like imminent brain death (IBD), which contains criteria in detail to determine potential heart-beating donors. Medical charts of 4814 patients who died on an ICU in Dutch university hospitals between January 2007 and December 2009 were reviewed for potential heart-beating donors. We compared two starting points: 'Severe Brain Damage' (SBD) (old definition) and IBD (new definition), which differ in the number of absent brainstem reflexes. Of the potential donors defined by IBD 45.6% fulfilled the formal brain death criteria, compared with 33.6% in the larger SBD group. This results in a higher DCR in the IBD group (40% vs. 29.5%). We illustrated important differences in DCRs when using two different definitions, even within one country. To allow comparison among countries and hospitals, one universal definition of a potential heart-beating donor should be used. Therefore, we propose the use of IBD.
Dutch Transplant Foundation, Leiden, The Netherlands. n.jansen@transplantatiestichting.nl
Nichon E
NE
Jansen
Yorick J
YJ
de Groot
Hendrik A
HA
van Leiden
Bernadette J J M
BJ
Haase-Kromwijk
Erwin J O
EJ
Kompanje
Andries J
AJ
Hoitsma
D000328:Adult; D000368:Aged; D001926:Brain Death / Q000145:classification*; D001933:Brain Stem / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012018:Reflex; D012189:Retrospective Studies; D014019:Tissue Donors / Q000145:classification*; D009927:Tissue and Organ Procurement / Q000379:methods*