Transdifferentiation of hepatic oval cells into pancreatic islet beta-cells.
Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcription factors (Pdx-1, Ngn-3, MafA). We explore the process of hepatic oval cell transdifferentiation into pancreatic islet beta-cells and the cellular signaling pathways involved.
Institute and Department of Endocrinology and Metabolism of Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ying
Y
Li
Li-Juan
LJ
Zhao
Fang-Zhen
FZ
Xia
Yan-Xiang
YX
Li
Ying-li
YL
Lu
D028341:Activins / Q000378:metabolism; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D054338:Cell Transdifferentiation / Q000187:drug effects / Q000502:physiology*; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000096:biosynthesis; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000166:cytology*; D016215:Macrophage-Activating Factors / Q000378:metabolism; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
D028341:Activins; D051792:Basic Helix-Loop-Helix Proteins; D016326:Extracellular Matrix Proteins; D005947:Glucose; D018398:Homeodomain Proteins; D007328:Insulin; D016215:Macrophage-Activating Factors; D009419:Nerve Tissue Proteins; D015534:Trans-Activators; C498695:NEUROG3 protein, human; C422405:activin A; C084010:pancreatic and duodenal homeobox 1 protein