The role of bioactive compounds on the promotion of neurite outgrowth.
Neurite loss is one of the cardinal features of neuronal injury. Apart from neuroprotection, reorganization of the lost neuronal network in the injured brain is necessary for the restoration of normal physiological functions. Neuritogenic activity of endogenous molecules in the brain such as nerve growth factor is well documented and supported by scientific studies which show innumerable compounds having neurite outgrowth activity from natural sources. Since the damaged brain lacks the reconstructive capacity, more efforts in research are focused on the identification of compounds that promote the reformation of neuronal networks. An abundancy of natural resources along with the corresponding activity profiles have shown promising results in the field of neuroscience. Recently, importance has also been placed on understanding neurite formation by natural products in relation to neuronal injury. Arrays of natural herbal products having plentiful active constituents have been found to enhance neurite outgrowth. They act synergistically with neurotrophic factors to promote neuritogenesis in the diseased brain. Therefore use of natural products for neuroregeneration provides new insights in drug development for treating neuronal injury. In this study, various compounds from natural sources with potential neurite outgrowth activity are reviewed in experimental models.
Department of Biotechnology, Research Institute for Biomedical and Health Science, Konkuk University, Chungju 380-701, Korea.
Sandeep Vasant
SV
More
Sushruta
S
Koppula
In-Su
IS
Kim
Hemant
H
Kumar
Byung-Wook
BW
Kim
Dong-Kug
DK
Choi
D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009414:Nerve Growth Factors / Q000737:chemistry / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D016501:Neurites / Q000187:drug effects* / Q000378:metabolism*; D055495:Neurogenesis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry
D001688:Biological Products; D009414:Nerve Growth Factors; D010936:Plant Extracts