Escherichia coli: great diversity around a common core.
Escherichia coli outbreak in Germany, which resulted in more than 4,000 cases, including 908 cases of hemolytic-uremic syndrome (HUS) and at least 50 deaths, highlighted the genome plasticity of E. coli and the potential for new virulent strains to emerge. The analysis of 170 E. coli genome sequences for the presence of nine previously identified protective extraintestinal pathogenic E. coli antigens suggested the feasibility of a combination vaccine as a universal intervention against all pathogenic E. coli strains.


OBJECTIVE
This article reports on the feasibility of a combination vaccine as a universal intervention against all pathogenic Escherichia coli strains.
Novartis Vaccines and Diagnostics, Sienna, Italy.
Danilo G
DG
Moriel
Roberto
R
Rosini
Kate L
KL
Seib
Laura
L
Serino
Mariagrazia
M
Pizza
Rino
R
Rappuoli
D000942:Antigens, Bacterial / Q000235:genetics; D017124:Conserved Sequence; D004196:Disease Outbreaks; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000382:microbiology*; D022361:Escherichia coli Vaccines / Q000235:genetics; D014644:Genetic Variation; D016680:Genome, Bacterial; D005858:Germany / Q000453:epidemiology; D006801:Humans
D000942:Antigens, Bacterial; D022361:Escherichia coli Vaccines