[Fatal haemophagocytic lymphohistiocytosis and mononucleosis in a patient with colitis ulcerosa].
We report a case of Epstein-Barr virus primo infection with the development of lethal haemophagocytic lymphohistiocytosis (HLH) in a 22 year-old man, who was being treated with azathioprin for colitis ulcerosa. HLH is a rare, life-threatening disease, which is caused by an inappropriate activation of the immune system with haemophagocytosis and multiorgan system dysfunction. Early initiation of treatment significantly improves survival.
Øre-næse-og halskirurgisk Afdeling, Rigshospitalet, Blegdamsvej 9, København Ø. ci@dadlnet.dk
Charlotte Juul
CJ
Ingvardsen
Vibe Cecilie
VC
Ballegaard
Preben
P
Homøe
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007244:Infectious Mononucleosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D008297:Male; D017410:Practice Guidelines as Topic; D012307:Risk Factors
D007166:Immunosuppressive Agents