Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection.
Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP) and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP), have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.
Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
Shu-Her
SH
Chiao
Siou-Hong
SH
Lin
Ching-I
CI
Shen
Jiunn-Wang
JW
Liao
I-Jiuan
IJ
Bau
Jiun-Chiou
JC
Wei
Li-Ping
LP
Tseng
Shan-hui
SH
Hsu
Ping-Shan
PS
Lai
Shinn-Zong
SZ
Lin
Jiang-Jen
JJ
Lin
Hong-Lin
HL
Su
D000538:Aluminum Silicates / Q000494:pharmacology* / Q000633:toxicity; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D002645:Chickens; D000077215:Clay; D004355:Drug Stability; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000737:chemistry; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity; D012480:Salmonella Infections / Q000188:drug therapy*; D019779:Salmonella enterica / Q000187:drug effects*; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D012834:Silver / Q000494:pharmacology* / Q000633:toxicity; D016019:Survival Analysis
D000538:Aluminum Silicates; D000900:Anti-Bacterial Agents; D012834:Silver; D000077215:Clay