Topical and systemic therapies for nickel allergy.
Nickel allergy can result in both cutaneous and systemic manifestations, and can range from mild to severe symptoms. A severe form of this allergy is the Systemic nickel allergy syndrome, clinically characterized by cutaneous manifestions (contact dermatitis, pompholyx, hand dermatitis dyshydrosis, urticaria) with chronic course and systemic symptoms (headache, asthenia, itching, and gastrointestinal disorders related to histopathological alterations of gastrointestinal mucosa, borderline with celiac disease). This review aims to briefly update the reader on past and current therapies for nickel contact allergy.
Department of Dermatology, University of Rome Sapienza, Rome, Italy.
Antonella
A
Tammaro
Alessandra
A
Narcisi
Severino
S
Persechino
Cristiano
C
Caperchi
Anthony
A
Gaspari
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000628:therapy*; D004035:Diet Therapy / Q000379:methods; D004221:Disulfiram / Q000008:administration & dosage; D004643:Emollients / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000628:therapy; D009532:Nickel / Q000009:adverse effects*; D010789:Phototherapy / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D015032:Zinc / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D004643:Emollients; D004791:Enzyme Inhibitors; D009532:Nickel; D015032:Zinc; D004221:Disulfiram