Evaluating objective and subjective quantitative parameters at the initial visit to predict future glaucomatous visual field progression.
OBJECTIVE
To evaluate the ability of structural assessment to predict glaucomatous visual field progression.


METHODS
A total of 119 healthy eyes with suspected glaucoma and glaucomatous eyes with 5 or more optic nerve stereophotographs, optical coherence tomography (OCT), and confocal scanning laser ophthalmoscopy (CSLO) all acquired within 6 months of each other were enrolled. Odds ratios to predict progression were determined by generalized estimating equation models.


RESULTS
Median follow-up was 4.0 years (range: 1.5 to 5.7 years). Fifteen eyes progressed by glaucoma progression analysis, 20 by visual field index, and 10 by both. Baseline parameters from stereophotographs (vertical cup-to-disc ratio and Disc Damage Likelihood Scale), OCT (global, superior quadrant, and inferior quadrant retinal nerve fiber layer thickness), and CSLO (cup shape measure and mean cup depth) were significant predictors of progression. Comparing the single best parameter from all models, only the OCT superior quadrant RNFL predicted progression.


CONCLUSIONS
Baseline stereophotographs, OCT, and CSLO measurements may be clinically useful to predict glaucomatous visual field progression.
UPMC Eye Center, Eye and Ear Institute, 203 Lothrop St., Pittsburgh, PA 15213, USA.
Allison K
AK
Ungar
Gadi
G
Wollstein
Hiroshi
H
Ishikawa
Lindsey S
LS
Folio
Yun
Y
Ling
Richard A
RA
Bilonick
Robert J
RJ
Noecker
Juan
J
Xu
Larry
L
Kagemann
Cynthia
C
Mattox
Joel S
JS
Schuman
D000553:Ambulatory Care; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis; D016017:Odds Ratio; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis*; D014792:Visual Acuity; D014794:Visual Fields