Serum SP-D levels as a biomarker of lung injury in children suffering of bronchopneumonia.
The efficacy of SP-D concentration as a useful biomarker of the severity of lung injury in children with bronchopneumonia with or without chronic airway disease was studied. A total of 48 patients (2 to 4 years old) diagnosed bronchopneumonia were admitted to Department of Pediatrics, Al-Dar hospital, Al-Madinah, Saudi Arabia over the year 2009. They were divided into two groups: G1 included patients without any underlying disease and G2 included asthmatic patients. They were assigned to one of three categories. Stage A patients without oxygen dosage, Stage B patients required oxygen dosage, and Stage C patients required ICU admission. We evaluated baseline characteristics, clinical features, and serum SP-D concentration in G1, G2, and G3a (healthy control cross-matched infants). The mean serum SP-D concentrations in G1 and G2 were higher than those in G3 (118.7 +/- 46.2 & 39.7 +/- 18.7 ng/ml, respectively), but also higher in G2 than in G1 (149.9 +/- 52.8 & 109.8 + 36.7 ng/ml, respectively). The mean serum SP-D concentrations were higher in Stage C than in Stages A or B patients, and mean serum SP-D concentrations were higher in Stage B than in Stage A.
Department of Pediatric Medicine, Faculty of Medicine, Cancer Institute, Cairo University, Cairo, Egypt.
Amira A Abd El-rahman
AA
Mosbah
Nahla A Bahgat
NA
Abdellatif
Ehab Ibrahim
EI
Sorour
Mohamed Fawzy M
MF
Awadallah
D015415:Biomarkers; D001996:Bronchopneumonia / Q000097:blood* / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*
D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D