Metabolic dysfunction under reduced estrogen levels:  looking to exercise for prevention.
Loss of estrogen function leads to the development of metabolic dysfunction that spans numerous tissues. In this review, we explore the concept that estrogens are critical for defining metabolic function in adipose and hepatic tissues and also the possibility that exercise training should be considered a substitute for estrogen replacement therapy in women with impairments in estrogen levels.
Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA. espen@umd.edu
Espen E
EE
Spangenburg
Lindsay M
LM
Wohlers
Ana P
AP
Valencia
D017667:Adipocytes / Q000473:pathology; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004967:Estrogens / Q000172:deficiency*; D015444:Exercise; D005260:Female; D006801:Humans; D006984:Hypertrophy; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism
D004967:Estrogens; D013230:Stearoyl-CoA Desaturase