Cardio-ankle vascular index in heterozygous familial hypercholesterolemia.
OBJECTIVE
The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls.


METHODS
82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9±14.9 years, were examined. CAVI was measured using the system VaSera® 1500.


RESULTS
CAVI in FH patients was significantly higher (8.0±1.4) than in healthy subjects (7.5±1.3) p = 0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p = 0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7).


CONCLUSIONS
The study showed no significant difference in CAVI between heterozygous FH and healthy controls.
2nd Clinic of Internal Medicine, Masaryk University of Brno, Czech Republic. vladimir.soska@fnusa.cz
Vladimir
V
Soska
Petr
P
Dobsak
Ladislav
L
Dusek
Kohji
K
Shirai
Jiri
J
Jarkovsky
Marie
M
Novakova
Petr
P
Brhel
Jana
J
Stastna
Lenka
L
Fajkusova
Tomas
T
Freiberger
Tomoyuki
T
Yambe
D000328:Adult; D055109:Ankle Brachial Index; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged