Plasma cell tumor of the clivus: report of two cases.
BACKGROUND
Plasma cell tumor only rarely affects the cranium and may be found as an isolated lesion or as a part of multiple myeloma. In this review we present the clinical and radiological characteristics and analyze the evolution of two cases of this tumor located at the skull base, specifically in the clivus and sellar region. We also present a brief review of the literature.


METHODS
Case #1: The patient was a 66-year-old female with a solitary plasmacytoma of the bone (the isolated form of plasma cell tumor) that was totally removed. Case #2: The patient was a 61-year-old male with the diffuse form of this disease who was submitted to subtotal removal. In both patients, adjuvant treatment based on radiotherapy and chemotherapy was proposed; however, only one patient (Case #2) accepted adjuvant treatment and had a very favorable result. Most clinical symptoms disappeared and the patient is currently alive and with a very good quality of life (>3-year follow-up). The other patient (Case #1), despite the presence of the localized form of the disease, died 3 months after diagnosis.


CONCLUSIONS
Early diagnosis and removal of as much of the tumor as possible, but mainly the opportune indication of adjuvant treatment with radiotherapy and chemotherapy, are the keys to management of these cases.
Neurocirugía del Hospital de Especialidades del Centro Médico Nacional Siglo XXI, México, Distrito Federal, Mexico. gguinto@prodigy.net.mx
Gerardo
G
Guinto-Balanzar
Miguel
M
Abdo-Toro
Norma
N
Aréchiga-Ramos
Roberto
R
Leal-Ortega
Erick
E
Zepeda-Fernández
María de Jesús
Mde J
Nambo-Lucio
D000368:Aged; D003388:Cranial Fossa, Posterior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000175:diagnosis / Q000628:therapy; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000628:therapy