N-domain isoform of Angiotensin I converting enzyme as a marker of hypertension: populational study.
The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n = 1150) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n = 795), ACE 90(+) (65/90) (n = 186), and ACE 90(-) (65/190) (n = 169) based on the presence (+) or absence (-) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90(+) compared with the ACE 90(-) and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90(+) group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90(-) group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.
Nephrology Division, Department of Medicine, Federal University of Sao Paulo, 740 Botucatu Street, 04023-900 Sao Paulo, SP, Brazil.
Leila C V
LC
Maluf-Meiken
Fernanda B
FB
Fernandes
Danielle S
DS
Aragão
Fernanda A
FA
Ronchi
Maria C C
MC
Andrade
Maria C
MC
Franco
Andreia C S
AC
Febba
Frida L
FL
Plavnik
José E
JE
Krieger
Jose G
JG
Mill
Ricardo C C
RC
Sesso
Dulce E
DE
Casarini