Pathophysiology of obesity-related renal dysfunction contributes to diabetic nephropathy.
Recent studies have demonstrated the role of insulin resistance in renal injury related to obesity, with hyperfiltration leading to glomerulomegaly in a pattern similar to that found in diabetic nephropathy. Similarities in the histologic patterns of damage from obesity and diabetes point to overlapping mechanisms of injury. In this review, we will examine the hormonal mechanisms, signaling pathways and injury patterns in renal injury resulting from obesity and attempt to draw conclusions on the reasons for these similarities.
Division of Kidney Diseases and Hypertension, Rhode Island and Miriam Hospitals, Providence, USA. gbayliss@lifespan.org
George
G
Bayliss
Larry A
LA
Weinrauch
John A
JA
D'Elia
D052242:Adiponectin / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D050199:Podocytes / Q000378:metabolism; D052243:Resistin / Q000097:blood; D015398:Signal Transduction; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D052242:Adiponectin; D020738:Leptin; D008565:Membrane Proteins; D052243:Resistin; C113267:nephrin