FT-IR study on interactions between medroxyprogesterone acetate and solvent in CHCl₃/cyclo-C6H₁₂ and CCl₄/cyclo-C6H₁₂ binary solvent systems.
The intermolecular interactions between medroxyprogesterone acetate (MPA) and CHCl(3) and CCl(4) solvent in CHCl(3)/cyclo-C(6)H(12) and CCl(4)/cyclo-C(6)H(12) binary solvent systems have been studied by Fourier transform infrared spectroscopy (FT-IR). The experimental results showed that there are hydrogen bonding interactions between oxygen atoms of all carbonyl groups in MPA and hydrogen atom of CHCl(3) so as to form 1:3 complex of MPA with CHCl(3) and produce three new absorption bands at 1728.9-1736.1, 1712.7-1717.4 and 1661.9-1673.8 cm(-1), respectively. And, 1:1 complex of MPA with CCl(4) is formed in CCl(4)/cyclo-C(6)H(12) binary solvent as a result of hydrogen bonding interaction between C3 carbonyl group and empty d-orbital in chlorine atom of CCl(4) leading to producing new absorption band at 1673.2-1674.2 cm(-1). However, all free carbonyl and associated carbonyl stretching vibrations of MPA in CHCl(3)/cyclo-C(6)H(12) and CCl(4)/cyclo-C(6)H(12) binary solvent systems shift to lower wavenumbers with the increasing of volume fraction of CHCl(3) and CCl(4) in binary solvent systems owing to the dipole-dipole interaction and the dipole-induced dipole interaction between MPA and solvents.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310032, China. shijh@zjut.edu.cn
Jie-hua
JH
Shi
Chun-hui
CH
Fan
D002251:Carbon Tetrachloride / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry*; D003510:Cyclohexanes / Q000737:chemistry*; D006860:Hydrogen Bonding; D017258:Medroxyprogesterone Acetate / Q000737:chemistry*; D012996:Solutions; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014732:Vibration
D003510:Cyclohexanes; D012996:Solutions; D012997:Solvents; C506365:Cyclohexane; D002725:Chloroform; D017258:Medroxyprogesterone Acetate; D002251:Carbon Tetrachloride