Levels of cathepsins in acute myocardial infarction.
OBJECTIVE
Over expression of matrix degrading enzymes have been implicated in plaque destabilisation and rupture. Cathepsins associated with extracellular matrix breakdown make them intriguing suspects. The aim of the study was to analyse peripheral levels of cathepsin B and cathepsin K and their inhibitor cystatin C during acute myocardial infarction (AMI).


METHODS
Study population included AMI patients at acute event (AMI group, n=48), stable angina patients (stable angina group n = 17), and healthy individuals (Control group, n=31). Cathepsin B, cathepsin K, cystatin C, and matrix metalloproteinases (MMP)-9 were analysed by enzyme-linked immunosorbent assay (ELISA) method.


RESULTS
Cathepsin B (45.9%) and cathepsin K (92.31%) at acute event of myocardial infarction (AMI group) increased (P=0.001) while cystatin C decreased marginally (12.5%) as compared to controls. Stable angina group, demonstrated only marginal reduction in all the parameters studied as compared to controls.


CONCLUSIONS
Cathepsin B and cathepsin K can be further evaluated as biomarkers in identifying high-risk individuals for AMI.
Research Scientist, Sir HN Medical Research Society, Sir HN Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai - 400004. kavita_shalia@hnhospital.com
Kavita K
KK
Shalia
Manoj R
MR
Mashru
Vinod K
VK
Shah
Surendra L
SL
Soneji
Satchidanand
S
Payannavar
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002401:Cathepsin B / Q000378:metabolism*; D056657:Cathepsin K / Q000378:metabolism*; D055316:Cystatin C / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology*
D015415:Biomarkers; D055316:Cystatin C; D002401:Cathepsin B; D056657:Cathepsin K; D020780:Matrix Metalloproteinase 9