Muscle diseases in the zebrafish.
Animal models in biomedical research are important for understanding the pathological mechanisms of human diseases at a molecular and cellular level. Several aspects of mammalian animals, however, may limit their use in modelling neuromuscular disorders. Many attributes of zebrafish (Danio rerio) are complementary to mammalian experimental systems, establishing the zebrafish as a powerful model organism in disease biology. This review focuses on a number of key studies using the zebrafish to model hereditary muscle diseases with additional emphasis on recent advances in zebrafish functional genomics and drug discovery. Increasing research in zebrafish disease models, combined with knowledge from mammalian models, will bring novel insights into the disease pathogenesis of neuromuscular disorders, as well as facilitate the development of effective therapeutic strategies.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom. YYL@sanger.ac.uk
Yung-Yao
YY
Lin
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000639:trends; D023281:Genomics; D009135:Muscular Diseases / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D012518:Sarcomeres / Q000502:physiology; D015027:Zebrafish / Q000235:genetics* / Q000502:physiology