Molecular mechanisms of IgE mediated food allergy.
The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also known as immediate type hypersensitivity or type I reaction. This review encompasses a wide range of molecular events during IgE mediated reactions like primary exposure of allergens, processing of allergens by antigen presenting cells, role of transcription factors like GATA-3, STAT-6, NF-AT, c-maf, c-kit and NF-κB, Treg cells, toll like receptors, cytokines and chemokines, class switch to IgE, FcεR1 receptor, priming of IgE on mast cells or basophils, signaling events followed by secondary exposure of allergens, degranulation and release of mediators like leukotrienes, histamines, prostaglandins, β-hexosaminidase and ultimately anaphylaxis. This review may be helpful to beginners as well as experts working in the field of allergy and immunology because of the stepwise explanations of molecular mechanisms involved in IgE mediated reactions.
Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research-CSIR-IITR, M.G. Marg, Post Box No. 80, Lucknow‐226001, India.
Sandeep
S
Kumar
Alok Kumar
AK
Verma
Mukul
M
Das
Premendra D
PD
Dwivedi
D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation; D015550:Cell Degranulation; D016207:Cytokines / Q000276:immunology; D005512:Food Hypersensitivity / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology*
D000485:Allergens; D016207:Cytokines; D018836:Inflammation Mediators; D051193:Toll-Like Receptors; D014157:Transcription Factors; D007073:Immunoglobulin E