Circadian rhythm-dependent alterations of gene expression in Drosophila brain lacking fragile X mental retardation protein.
Fragile X syndrome is caused by the loss of the FMR1 gene product, fragile X mental retardation protein (FMRP). The loss of FMRP leads to altered circadian rhythm behaviors in both mouse and Drosophila; however, the molecular mechanism behind this phenomenon remains elusive. Here we performed a series of gene expression analyses, including of both mRNAs and microRNAs (miRNAs), and identified a number of mRNAs and miRNAs (miRNA-1 and miRNA-281) with circadian rhythm-dependent altered expression in dfmr1 mutant flies. Identification of these RNAs lays the foundation for future investigations of the molecular pathway(s) underlying the altered circadian rhythms associated with loss of dFmr1.
Department of Neurology, 2nd Hospital of Shandong University, Jinan City, Shandong Province, People's Republic of China. sl_hsu@yahoo.com
Shunliang
S
Xu
Mickael
M
Poidevin
Enji
E
Han
Jianzhong
J
Bi
Peng
P
Jin
D000818:Animals; D001921:Brain / Q000378:metabolism; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D017353:Gene Deletion; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*
D029721:Drosophila Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1; D035683:MicroRNAs; D012333:RNA, Messenger; C467328:FMR1 protein, Drosophila; C574927:MIRN1 microRNA, Drosophila