[Experimental approaches to investigation into the role of the genotype by the locus TAG 1A of dopamine D2-receptors in epileptogenesis].
The effect of genotype in locus TAG 1A of gene receptor dopamine second type on characteristics of peak-and-wave EEG pattern in somatosensory, parietal and occipital areas of the cortex was studied in two groups of rats. Quantitative analysis showed that the peak-wave discharge of the first type in rats with A1/A1 genotype had a significantly longer duration, occurred more frequently leading to a significant increase in their peak-wave index. The results are of clinical interest creating a theoretical basis for improved diagnosis of absence epilepsy and selection of anticonvulsants.
L B
LB
Kalimullina
A M
AM
Musina
G D
GD
Kuznetsova
D000161:Acoustic Stimulation; D000483:Alleles; D000818:Animals; D001931:Brain Mapping; D004569:Electroencephalography / Q000379:methods*; D004832:Epilepsy, Absence / Q000235:genetics* / Q000473:pathology*; D005838:Genotype; D008297:Male; D011110:Polymorphism, Genetic; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000235:genetics*
D017448:Receptors, Dopamine D2