Partially hydrolyzed guar gums reduce dietary fatty acid and sterol absorption in guinea pigs independent of viscosity.
This study investigated the effect of two partially hydrolyzed guar gums (PHGG) on fatty acid and sterol excretion. PHGG were obtained by chemical hydrolysis of guar gum (GG) with H(2)O:EtOH (1:1) at 100 °C for 1 h (PHGG1) or 2 h (PHGG2). The viscosity of the PHGG in a 1 % (w/v) aqueous solution corresponded to that of a pseudoplastic fluid and was higher for PHGG1 than PHGG2. Guinea pigs (n = 8 per group) were fed high fat diets (17/100 g) that contained 12/100 g of cellulose, PHGG1, or PHGG2 for 4 weeks. Despite the differences in viscosity, the two PHGG exerted similar physiological effects. Compared to the control cellulose group, the body weight gain was lower in animals fed PHGG, although no effect on food consumption was observed. PHGG increased the excretion of fatty acids and neutral sterols, but not bile acids. Consumption of PHGG did not alter the fecal fatty acid profile, while intestinal bioconversion of sterols tended to increase in response to PHGG2. A reduction in the viscosity within the range tested did not correlate with losses in the hypocholesterolemic capacity of PHGG as both were effective in reducing plasma cholesterol. Thus, we conclude that the chemical hydrolysis of guar gum renders the gum suitable for inclusion in food products without significantly altering its beneficial health effects.
Department of Nutrition and Food Science, XaRTA-INSA, University of Barcelona, 08028, Barcelona, Spain.
Jonathan
J
Santas
Jordi
J
Espadaler
Jordi
J
Cuñé
Magda
M
Rafecas
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D059305:Diet, High-Fat; D004043:Dietary Fiber / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005685:Galactans / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D050356:Lipid Metabolism / Q000187:drug effects; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology*; D053149:Plant Gums / Q000737:chemistry / Q000494:pharmacology*; D013261:Sterols / Q000378:metabolism*; D014783:Viscosity / Q000187:drug effects
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005227:Fatty Acids; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013261:Sterols; C007894:guar gum