Intra-CSF administration of chemotherapy medications.
Leptomeningeal carcinomatosis is a devastating complication of cancer and is likely increasing in incidence. The combination of widespread neuro-axial spread based on CSF flow and the blood-brain barrier (BBB) has favored immediate local delivery of antineoplastic agents. With the BBB, the leptomeninges can be a sanctuary site to systemic cancers and goal of therapy includes preventing involvement in this space. Current therapies with U.S. Food and Drug Administration (FDA) approval are limited to treat hematologic cancers. Although lacking FDA guidance, a wider array of therapies is available to treat solid tumors. We provide an updated examination on both well-established intra-CSF chemotherapies as well as agents having limited data, but reports of therapeutic benefit.
Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA.
Michael P
MP
Gabay
Jigisha P
JP
Thakkar
Joan M
JM
Stachnik
Susan K
SK
Woelich
J Lee
JL
Villano
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007276:Injections, Intraventricular; D055756:Meningeal Carcinomatosis / Q000188:drug therapy*; D013129:Spinal Puncture; D016896:Treatment Outcome
D000970:Antineoplastic Agents