Sleep disturbance, inflammation and depression risk in cancer survivors.
Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.
University of California, Los Angeles - Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, CA 90095-7076, USA. mirwin1@ucla.edu
Michael R
MR
Irwin
Richard E
RE
Olmstead
Patricia A
PA
Ganz
Reina
R
Haque
D003863:Depression / Q000209:etiology* / Q000523:psychology; D003866:Depressive Disorder / Q000209:etiology* / Q000523:psychology; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000523:psychology; D009369:Neoplasms / Q000150:complications* / Q000523:psychology; D011788:Quality of Life; D012306:Risk; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000523:psychology; D017741:Survivors / Q000523:psychology*