Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response.
A 20-y-old male presented with symptoms of meningococcal sepsis and died despite appropriate medical interventions. Blood cultures grew N. meningitidis serogroup Y. The patient had received the meningococcal quadrivalent (A,C,W-135,Y) polysaccharide vaccine 15 mo previously. Because the patient had a history of meningococcal meningitis at age 10, archived serum was obtained for further analysis. Complement component C7 was found to be deficient, and antibody levels to meningococcal polysaccharides were undetectable for two serogroups and low for the infecting serogroup 10 mo post-vaccination. This case highlights the fact that some individuals with terminal complement component deficiencies mount an impaired or short-lived response to vaccination with meningococcal capsular polysaccharides, and underscores the appropriateness of a more aggressive vaccination strategy in this patient population.
Department of Allergy/Immunology/Immunizations, Walter Reed National Military Medical Center, Bethesda, MD, USA. paul.keiser@us.army.mil
Paul B
PB
Keiser
Michael
M
Broderick
D000907:Antibodies, Bacterial / Q000097:blood*; D003184:Complement C7 / Q000172:deficiency; D017809:Fatal Outcome; D000081208:Hereditary Complement Deficiency Diseases; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000276:immunology; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D038581:Neisseria meningitidis, Serogroup Y / Q000276:immunology / Q000302:isolation & purification; D018805:Sepsis / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult
D000907:Antibodies, Bacterial; D003184:Complement C7; D022401:Meningococcal Vaccines