Cachexia and oxidative stress in cancer: an innovative therapeutic management.
Cachexia influences morbidity, mortality and quality of life of cancer patients at advanced stage of disease. Therefore, the knowledge of its pathophysiology is critical to develop effective therapies to be integrated in the comprehensive approach of cancer patients. Oxidative stress, unless counteracted by effective antioxidant therapies, contributes to the development of anorexia and cachexia in cancer patients. In the present review the potential role of targeting oxidative stress in the treatment of cachexia is reported. Efficacy data on the use of antioxidants in advanced cancer patients are promising. However, the optimal dosage and route of administration as well as the timing and the most effective combination are not well established. Moreover, since cachexia is a multifactorial syndrome, targeting only oxidative stress as a contributing factor would be inadequate and likely to achieve a limited clinical therapeutic benefit. According to this rationale, antioxidants should be included as essential components of a multitargeted combined treatment of cancer cachexia, which has been shown to be the most successful approach for this syndrome.
Department of Medical Oncology, University of Cagliari SS 554, km 4.500, 09042 Monserrato, Cagliari, Italy. mantovan@medicina.unica.it
Giovanni
G
Mantovani
Clelia
C
Madeddu
Antonio
A
Macciò
D000818:Animals; D000855:Anorexia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D019167:Appetite Stimulants / Q000627:therapeutic use; D002100:Cachexia / Q000178:diet therapy* / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D019587:Dietary Supplements; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D000975:Antioxidants; D019167:Appetite Stimulants