Claudin expression profile separates Alzheimer's disease cases from normal aging and from vascular dementia cases.
We have reported earlier that tight-junction proteins are detectable by standard immunohistochemistry in the brain parenchyma, namely in the cell bodies of neurons, astrocytes, and oligodendrocytes. Here we show, by projection to latent structures - discriminate analysis (PLS-DA), that the immunohistochemical detection profile of tight junction proteins clearly distinguishes the AD cases from healthy aging controls and from the cases of dementia with a predominantly vascular pathology underlying the symptoms (vascular dementia, VaD; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL; and cerebral amyloid angiopathy, CAA). Our findings might be valuable in the perspective of developing biomarkers for AD.
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stefan
S
Spulber
Nenad
N
Bogdanovic
Mihaela Oana
MO
Romanitan
Ovidiu A
OA
Bajenaru
Bogdan O
BO
Popescu
D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D057167:Claudins / Q000378:metabolism*; D015140:Dementia, Vascular / Q000145:classification / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D025341:Principal Component Analysis
D057167:Claudins