Microwave-enhanced solid-phase synthesis of N,N'-linked aliphatic oligoureas and related hybrids.
A practical and efficient microwave-assisted solid-phase method for the synthesis of N,N'-linked oligoureas and related amide/urea hybrid oligomers, featuring the use of succinimidyl (2-azido-2-substituted ethyl) carbamate monomers, is reported. The rate enhancement of urea formation under microwave irradiation combined with the mild conditions of the phosphine-based azide reduction makes this approach very effective for routine synthesis of oligoureas and possibly for library production.
Université de Bordeaux -CNRS UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac Cedex, France.
Céline
C
Douat-Casassus
Karolina
K
Pulka
Paul
P
Claudon
Gilles
G
Guichard
D001386:Azides / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D060327:Solid-Phase Synthesis Techniques; D014508:Urea / Q000138:chemical synthesis*
D001386:Azides; D014508:Urea