CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma.
The signaling pathways facilitating metastasis of head and neck squamous cell carcinoma (HNSCC) cells are not fully understood. CD147 is a transmembrane glycoprotein known to induce cell migration and invasion. AGR2 is a secreted peptide also known to promote cell metastasis. Here we describe their importance in the migration and invasion of HNSCC cells (FADU and OSC-19) in vitro and in vivo. In vitro, knockdown of CD147 or AGR2 decreased cellular proliferation, migration and invasion. In vivo, knockdown of CD147 or AGR2 expression decreased primary tumor growth as well as regional and distant metastasis.
Department of Surgery, University of Alabama, Division of Otolaryngology-Head and Neck Surgery, Birmingham, Alabama, USA. larissasweeny@gmail.com
Larissa
L
Sweeny
Zhiyong
Z
Liu
Benjamin D
BD
Bush
Yolanda
Y
Hartman
Tong
T
Zhou
Eben L
EL
Rosenthal
D000818:Animals; D051926:Basigin / Q000096:biosynthesis* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000556:secondary*; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009088:Mucoproteins; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D015513:Oncogene Proteins; D011506:Proteins / Q000378:metabolism*; D014407:Tumor Cells, Cultured
C502296:AGR2 protein, human; C497886:BSG protein, human; D009088:Mucoproteins; D015513:Oncogene Proteins; D011506:Proteins; D051926:Basigin