Synthesis of berbamine acetyl glycosides and evaluation of antitumor activity.
A series of berbamine glycosides was designed, synthesized and evaluated as a new class of antitumor agents. An efficient glycosylation route was developed for berbamide derivatives. The newly synthesized glycosides were evaluated for their cytotoxic activity in vitro against a human leukemia cell line K562, a human lung adenocarcinoma cell line A549 and mouse lymphocytic leukemia cells L1210. In contrast to berbamine most of its glycosides manifested potent cytotoxic activities. The acetyl glycosyl berbamine 5a, 5d caused distinct improvement against K562, A549 and L1210. It is suggested that the acetyl D-glucose residue has affinity to these cancer cells.
Department of Chemistry, Zhejiang University, Zheda Road 38, Hangzhou 310027, PR China. hnzzcyl@hotmail.com
Yanli
Y
Cui
Minghan
M
Xu
Jianwei
J
Mao
Jingfeng
J
Ouyang
Rongzhen
R
Xu
Yongping
Y
Yu
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044182:Benzylisoquinolines / Q000737:chemistry*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; D006027:Glycosides; C027870:berbamine