[Peculiarities of stress erosive ulcerous injuries of stomach and small intestine].
OBJECTIVE
The aim of this investigation is to estimate the role of systemic injuries of lipid metabolism in pathogenesis of ulceration on the model of stress ulcerogenesis.


METHODS
There have been assumed as a basis of the work experimental investigations on 60 pubertal white rats of both sexes weighing 200 gr. There was studied the state of macroscopic picture of stomach and small intestine, qualitative and quantitative lipid composition, lipid peroxidation, phospholipase A2, catalase, superoxide dismutase in stomach tissues, small intestine and blood plasma.


RESULTS
The facts of the experimental investigations show, that by the effect of ulceration stress there are processes, that underlie modifications of lipid components of cell structures' biomembranes, and registered by qualitative and quantitative changes of lipid composition. Intensification of lipid peroxidation and activation of phospholipase A2 are the key mechanisms of qualitative and quantitative composition of biomembranes' lipid components, and they reduce to beginnings of cascade of pathomorphological and pathophysiological reactions in cell structures, which cause beginnings of membrane destructive processes, that is as a basis of ulcerogenesis.


CONCLUSIONS
In the result there is broken morphofunctional state of mucous membrane (one of the main factors of protection), that in the end makes it accessible substratum for other aggressive factors and promotes the formation of ulcerous defects.
L V
LV
Mosina
L V
LV
Matveeva
E A
EA
Mitina
A E
AE
Geras'kin
D000818:Animals; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D013276:Stomach Ulcer / Q000378:metabolism* / Q000473:pathology; D013312:Stress, Physiological
D010088:Oxidoreductases; D010741:Phospholipases A