[Role of receptor transactivation in the cardioprotective effects of preconditioning and postconditioning].
Analysis of published data indicates that the activity of receptors for adenosine, opioids, bradykinin, calcitonin-gene related peptides (CGRP) and epidermal growth factor (EGF) play important role in triggering the cardioprotective effects of ischemic preconditioning. Cannabinoids mimic the infarct-sparing effects of preconditioning. Endogenous adenosine, opioids, bradykinin and CGRP have also been implicated in infarct-reduction with ischemic postconditioning. Again, cannabinoids also mimic the protective effect of postconditioning. Recent works support heterodimerization of G-protein coupled receptors (GPCRs), and GPCR transactivation of EGF receptors. It was found that cross-talk between delta(j)-opioid receptors and adenosine A(1)-receptors is essential to cardiac protection. Furthermore, evidence implicates EGF receptor transactivation in cardioprotective effect of multiple GPCrs including adenosine, acetylcholine, bradykinin, and opioid receptors. Such findings support a convergent pathway in which multiple GPCRs may interact (or function independently) to transactivate EGF receptor-dependent kinase signaling and cytoprotection.
L N
LN
Maslov
J P
JP
Headrick
R
R
Mechoulam
A V
AV
Krylatov
A Iu
AIu
Lishmanov
E I
EI
Barzakh
N V
NV
Naruzhnaia
Y
Y
Zhang
D000109:Acetylcholine / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism*; D001920:Bradykinin / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D015398:Signal Transduction
D018015:Receptors, Calcitonin Gene-Related Peptide; D011957:Receptors, Opioid; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D000241:Adenosine; D000109:Acetylcholine; D001920:Bradykinin