PABPN1 shuts down alternative poly(A) sites.
Although overlooked for many years, alternative cleavage and polyadenylation (APA) is now emerging as a major mechanism of gene regulation. A recent study identifies poly(A)-binding protein nuclear 1 (PABPN1), a general factor of polyadenylation, as a suppressor of alternative poly(A) sites.
mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, Montpellier Cedex 5, France. Martine.Simonelig@igh.cnrs.fr
Martine
M
Simonelig
D020413:3' Untranslated Regions; D000818:Animals; D002460:Cell Line; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009154:Mutation; D011061:Poly A / Q000378:metabolism*; D039122:Poly(A)-Binding Protein I / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
D020413:3' Untranslated Regions; D029721:Drosophila Proteins; D039122:Poly(A)-Binding Protein I; D012333:RNA, Messenger; D029702:Schizosaccharomyces pombe Proteins; D011061:Poly A