An unusual case of an osteosarcoma arising in a leiomyoma of the uterus.
Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies.
Department of Pathology, Ondokuz Mayis University, Medical School, Gazi State Hospital, Samsun, Turkey. mehmetkefeli@gmail.com
Mehmet
M
Kefeli
Sancar
S
Baris
Oguz
O
Aydin
Levent
L
Yıldız
Seda
S
Yamak
Bedri
B
Kandemir
D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*