Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis.
There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M. pneunomiae strains was investigated using the multilocus variable-number tandem-repeat assay (MLVA). Among 152 M. pneunomiae isolates, the 137 macrolide-resistant strains were clustered into 15 MLVA types, indicating that the high macrolide resistance rate in M. pneumoniae is a result of the dissemination of the multiple resistant clones.
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Yang
Y
Liu
Xinye
X
Ye
Hong
H
Zhang
Xiaogang
X
Xu
Minggui
M
Wang
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology / Q000379:methods; D058889:Molecular Typing; D009177:Mycoplasma pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000453:epidemiology / Q000382:microbiology
D000900:Anti-Bacterial Agents; D018942:Macrolides