Preparation of quinolinium salts differing in the length of the alkyl side chain.
Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C₈ to C₂₀) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. In vitro testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and Candida species.
Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove 50001, Czech Republic.
Jan
J
Marek
Vladimir
V
Buchta
Ondrej
O
Soukup
Petr
P
Stodulka
Jiri
J
Cabal
Kallol K
KK
Ghosh
Kamil
K
Musilek
Kamil
K
Kuca
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008826:Microbial Sensitivity Tests; D011806:Quinolinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012492:Salts
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011806:Quinolinium Compounds; D012492:Salts