Probiotics in the treatment of the liver diseases.
The concept that interactions between the gut, the liver, and the immune system play an important role in liver diseases is an old concept that has recently seen a resurgence in interest. Altered intestinal bacterial flora and gut-associated endotoxemia are increasingly recognized as critical components in both nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Probiotics have been proposed in the treatment and prevention of many conditions, including the liver diseases. Probiotics are live microorganisms that, when consumed in adequate amounts, confer a health benefit to the host. There are many mechanisms by which probiotics enhance intestinal health and influence the gut-liver axis, including modulation of the intestinal microflora, modification of intestinal barrier function, and immunomodulation. The present review summarizes the recent studies highlighting the role of the intestinal microflora in the development of NAFLD and ALD and the potential efficacy of probiotics as a therapeutic strategy for liver diseases.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, KY 40202, USA.
Irina A
IA
Kirpich
Craig J
CJ
McClain
D000818:Animals; D019446:Endotoxemia / Q000150:complications / Q000628:therapy; D005234:Fatty Liver / Q000150:complications / Q000628:therapy*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000628:therapy*; D023421:Models, Animal; D065626:Non-alcoholic Fatty Liver Disease; D056692:Prebiotics / Q000382:microbiology; D019936:Probiotics / Q000008:administration & dosage*; D013559:Symbiosis
D056692:Prebiotics