[Effects of L-carnitine on ejaculate parameters in males from infertile couples].
The aim of our investigation was detection of molecular mechanisms of an antioxidant action of L-carnitine (a transmembrane carrier of long-chain fatty acids) in idiopathic pathospermia. We treated 60 males from infertile couples with karniton (1 g/day). L-carnitine impact on ejaculate antioxidant status was assessed by registration of chemiluminescence and total antioxidant activity by colorimetric method according to changes in the color of ABTS chromogen. High dose-dependent antioxidant activity of the drug was found in testing on model systems in vitro. In vivo trials showed that patients given L-carnitine demonstrated a significant increase of the number of mobile spermatozoa of A category, positive changes in parameters of luminal-dependent and Fe2+ induced chemiluminescence of ejaculate in elevated antioxidant capacity of spermoplasma. After karniton treatment of the husbands 23% of their wives got pregnant. The treatment efficacy may be due to normalization of antioxidant status of ejaculate.
Sh N
ShN
Galimov
D S
DS
Gromenko
É F
ÉF
Galimova
Iu Iu
IuIu
Gromenko
I R
IR
Iskhakov
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002331:Carnitine / Q000494:pharmacology*; D004542:Ejaculation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D013094:Spermatozoa / Q000187:drug effects*; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002331:Carnitine