Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls.
To identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.
Institute of Psychiatry - University of Sao Paulo, Medical School (FMUSP), São Paulo (SP), Brazil; CIPE - AC Camargo Hospital, São Paulo (SP), Brazil.
Mariana
M
Maschietto
Aderbal R
AR
Silva
Renato D
RD
Puga
Leandro
L
Lima
Carlos B
CB
Pereira
Eduardo Y
EY
Nakano
Barbara
B
Mello
Clarissa S
CS
Gama
Paulo
P
Belmonte-de-Abreu
Dirce M
DM
Carraro
Joana A
JA
Palha
Helena
H
Brentani
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D012680:Sensitivity and Specificity
D014150:Antipsychotic Agents; D015415:Biomarkers