Role of E-cadherin and other cell adhesion molecules in survival and differentiation of human pluripotent stem cells.
The survival, proliferation, self-renewal and differentiation of human pluripotent stem cells (hPSCs, including human embryonic stem cells and human induced pluripotent stem cells) involve a number of processes that require cell-cell and cell-matrix interactions. The cell adhesion molecules (CAMs), a group of cell surface proteins play a pivotal role in mediating such interactions. Recent studies have provided insights into the essential roles and mechanisms of CAMs in the regulation of hPSC fate decisions. Here, we review the latest research progress in this field and focus on how E-cadherin and several other important CAMs including classic cadherins, Ig-superfamily CAMs, integrins and heparin sulfate proteoglycans control survival and differentiation of hPSCs.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON Canada.
Li
L
Li
Steffany A L
SA
Bennett
Lisheng
L
Wang
D015703:Antigens, CD / Q000378:metabolism; D001665:Binding Sites; D015820:Cadherins / Q000378:metabolism; D002454:Cell Differentiation; D002470:Cell Survival; D021982:Cell-Matrix Junctions / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D019812:Heparan Sulfate Proteoglycans; D016023:Integrins; D000099152:Cadherin 5; C050361:CDH2 protein, human