Development and validation of a risk calculator for prediction of mortality after infrainguinal bypass surgery.
OBJECTIVE
For peripheral arterial disease, infrainguinal bypass grafting (BPG) carries a higher perioperative risk compared with peripheral endovascular procedures. The choice between the open and endovascular therapies is to an extent dependent on the expected periprocedural risk associated with each. Tools for estimating the periprocedural risk in patients undergoing BPG have not been reported in the literature. The objective of this study was to develop and validate a calculator to estimate the risk of perioperative mortality ≤30 days of elective BPG.


METHODS
We identified 9556 patients (63.9% men) who underwent elective BPG from the 2007 to 2009 National Surgical Quality Improvement Program data sets. Multivariable logistic regression analysis was performed to identify risk factors associated with 30-day perioperative mortality. Bootstrapping was used for internal validation. The risk factors were subsequently used to develop a risk calculator.


RESULTS
Patients had a median age of 68 years. The 30-day mortality rate was 1.8% (n = 170). Multivariable logistic regression analysis identified seven preoperative predictors of 30-day mortality: increasing age, systemic inflammatory response syndrome, chronic corticosteroid use, chronic obstructive pulmonary disease, dependent functional status, dialysis dependence, and lower extremity rest pain. Bootstrapping was used for internal validation. The model demonstrated excellent discrimination (C statistic, 0.81; bias-corrected C statistic, 0.81) and calibration. The validated risk model was used to develop an interactive risk calculator using the logistic regression equation.


CONCLUSIONS
The validated risk calculator has excellent predictive ability for 30-day mortality in a patient after an elective BPG. It is anticipated to aid in surgical decision making, informed patient consent, preoperative optimization, and consequently, risk reduction.
Department of Surgery, Creighton University, Omaha, Neb., USA.
Prateek K
PK
Gupta
Bala
B
Ramanan
Thomas G
TG
Lynch
Abhishek
A
Sundaram
Jason N
JN
MacTaggart
Himani
H
Gupta
Xiang
X
Fang
Iraklis I
II
Pipinos
D001157:Arterial Occlusive Diseases / Q000401:mortality* / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007264:Inguinal Canal / Q000098:blood supply*; D016015:Logistic Models; D015233:Models, Statistical; D015999:Multivariate Analysis; D018570:Risk Assessment