[The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, aconitase and citrate synthase activities at ischemia-reperfusion of rats brain].
The influence of some guanidine derivatives on the level of brain citrate, brain activities of aconitase and citrate synthase has been investigated in rats subjected to ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Treatment with these compounds also decreased the degree of DNA fragmentation markedly increased in rats with ischemia-reperfusion.
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Sukhoveeva
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Popova
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Makeeva
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Iskusnykh
D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D002950:Citrate (si)-Synthase / Q000378:metabolism*; D019343:Citric Acid / Q000032:analysis / Q000097:blood / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D008297:Male; D008760:Methylguanidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D009025:Morpholines; C573673:N-(imino(1-piperidinyl)methyl)guanidine; C550620:N-(imino(4-morpholyl)methyl)guanidine; D018696:Neuroprotective Agents; D010880:Piperidines; D019343:Citric Acid; D008760:Methylguanidine; D002950:Citrate (si)-Synthase; D000154:Aconitate Hydratase