Ultradeformable liposomes with terpenes for delivery of hydrophilic compound.
Ultradeformable liposomes containing penetration enhancers were created to deliver NaFl. Vesicles were investigated for their particle size, zeta potential, NaFl entrapment efficiency (%EE), loading efficiency, and in vitro skin penetration. The vesicles obtained were spherical in shape, with a particle size of less than 100 nm and a negative surface charge (-6 to -11 mV). The %EE of NaFl loaded in vesicles ranged from 37 to 48%. Ultradeformable liposomes with monoterpenes (d-limonene, 1,8-cineole and geraniol) significantly improved NaFl penetration through the skin. Confocal laser scanning microscopy analysis confirmed skin-penetration results and was used to evaluate the behavior of hydrophilic compounds penetrating through the skin.
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Thirapit
T
Subongkot
Sureewan
S
Duangjit
Theerasak
T
Rojanarata
Praneet
P
Opanasopit
Tanasait
T
Ngawhirunpat
D000080462:Acyclic Monoterpenes; D000279:Administration, Cutaneous; D000818:Animals; D000831:Animals, Newborn; D003511:Cyclohexanols / Q000737:chemistry; D053138:Cyclohexenes / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D000077591:Eucalyptol; D019793:Fluorescein / Q000008:administration & dosage* / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D000077222:Limonene; D008081:Liposomes; D018613:Microscopy, Confocal; D039821:Monoterpenes / Q000737:chemistry; D010316:Particle Size; D012867:Skin; D012869:Skin Absorption; D055672:Static Electricity; D013499:Surface Properties; D013552:Swine; D013729:Terpenes / Q000737:chemistry*
D000080462:Acyclic Monoterpenes; D003511:Cyclohexanols; D053138:Cyclohexenes; D004337:Drug Carriers; D008081:Liposomes; D039821:Monoterpenes; D013729:Terpenes; D000077222:Limonene; C007836:geraniol; D000077591:Eucalyptol; D019793:Fluorescein