Tudor domain proteins in development.
Tudor domain proteins function as molecular adaptors, binding methylated arginine or lysine residues on their substrates to promote physical interactions and the assembly of macromolecular complexes. Here, we discuss the emerging roles of Tudor domain proteins during development, most notably in the Piwi-interacting RNA pathway, but also in other aspects of RNA metabolism, the DNA damage response and chromatin modification.
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604. pek@ciwemb.edu
Jun Wei
JW
Pek
Amit
A
Anand
Toshie
T
Kai
D000818:Animals; D001120:Arginine / Q000737:chemistry / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D006801:Humans; D008239:Lysine / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051379:Mice; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism; D012326:RNA Splicing; D034741:RNA, Small Interfering / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D002843:Chromatin; D029721:Drosophila Proteins; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; D012313:RNA; D001120:Arginine; D008239:Lysine