Study of clinical and aetiological profile of 100 patients of pancytopenia at a tertiary care centre in India.
Pancytopenia is not a disease but an important clinico-haematological entity encountered in our day-to-day clinical practice with findings that may result from a number of disease processes. A total of 100 patients of pancytopenia admitted in medicine wards of Civil Hospital, Ahmedabad, Gujuarat, India, were studied. The most common cause of pancytopenia was megaloblastic anaemia (45%) followed by infections (20%) and hypersplenism (15%). As compared with other causes, megaloblastic anaemia was statistically significant cause (P < 0.01) of pancytopenia, in our study. The most common clinical presentation of patients with megaloblastic anaemia was lethargy (100%) and pallor (100%). In patients with megaloblastic anaemia, mean haemoglobin (Hb) was 5.6 ± 1.7 g/dl, mean white blood corpuscle (WBC) count was 2735 ± 4152 and mean platelet count was 52,250 ± 24,213. Mean corpuscular volume (MCV) was 101.2 ± 11 in patients of megaloblastic anaemia. Morphology of RBC was marocytic in 95% of patients with megaloblastic anaemia, whereas hypersegmented neutrophils and macrovalocytes were seen in 60-65% patients of megaloblastic anaemia.
Medicine Department, D-4 Civil Hospital, Ahmedabad, Gujarat, India.
Dhaval
D
Doshi
Asha N
AN
Shah
Shrikant
S
Somani
Abhinav
A
Jain
Harsha
H
Jivarajani
Pooja
P
Kothari
D000328:Adult; D000368:Aged; D000749:Anemia, Megaloblastic / Q000150:complications / Q000473:pathology*; D001772:Blood Cell Count; D003141:Communicable Diseases / Q000150:complications / Q000473:pathology*; D003151:Community Health Centers; D004909:Erythrocyte Indices; D006801:Humans; D006971:Hypersplenism / Q000150:complications / Q000473:pathology*; D007194:India; D053609:Lethargy / Q000503:physiopathology; D008875:Middle Aged; D010167:Pallor / Q000503:physiopathology; D010198:Pancytopenia / Q000209:etiology / Q000473:pathology*