Clinical epidemiologic profile of a cohort of post-kala-azar dermal leishmaniasis patients in Bihar, India.
Post-kala-azar dermal leishmaniasis (PKDL) has important public health implications for transmission of visceral leishmaniasis (VL). Clinical and epidemiologic profiles of 102 PKDL patients showed that median age of males and females at the time of diagnosis was significantly different (P = 0.013). A significant association was observed between family history of VL and sex of PKDL patients (χ(2) = 5.72, P < 0.01). Nearly 33% of the patients showed development of PKDL within one year of VL treatment. The observed time (median = 12 months) between appearance of lesions and diagnosis is an important factor in VL transmission. A significant association was observed between type of lesions and duration of appearance after VL treatment (χ(2) = 6.59, P = 0.001). Because PKDL was observed during treatment with all currently used anti-leishmanial drugs, new drug regimens having high cure rates and potential to lower the PKDL incidence need to be investigated.
Rajendra Memorial Research Institute of Medical Sciences (ICMR), Agamkuan, Patna, Bihar, India. drvnrdas@yahoo.com
Vidya Nand Rabi
VN
Das
Alok
A
Ranjan
Krishna
K
Pandey
Dharmendra
D
Singh
Neena
N
Verma
Sushmita
S
Das
Chandra S
CS
Lal
Naresh K
NK
Sinha
Rakesh B
RB
Verma
Niyamat A
NA
Siddiqui
Pradeep
P
Das
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D000981:Antiprotozoal Agents; D000666:Amphotericin B