Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa.
Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, X-ray diffraction, and CD analyses. Compounds 1 and 2 represent the first examples of Securinega alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways were also proposed.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
Bing-Xin
BX
Zhao
Ying
Y
Wang
Dong-Mei
DM
Zhang
Xiao-Jun
XJ
Huang
Liang-Liang
LL
Bai
Yan
Y
Yan
Jia-Mei
JM
Chen
Tong-Bu
TB
Lu
Yi-Tao
YT
Wang
Qing-Wen
QW
Zhang
Wen-Cai
WC
Ye
D002942:Circular Dichroism; D019665:Euphorbiaceae / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014326:Tropanes / Q000737:chemistry* / Q000302:isolation & purification
D014326:Tropanes; C576140:virosaine A; C576141:virosaine B