Statins may help lower depression risk.  The key could be that the medication reduces atherosclerosis in the brain.
D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors