Amphiregulin is a prognostic factor in colorectal cancer.
Amphiregulin is an epidermal growth factor (EGF) which is a ligand of epidermal growth factor receptor (EGFR). Amphiregulin is the most enhanced EGFR ligand in colon cancer. Here we report on the expression of Amphiregulin using immunohistochemical staining in primary colorectal cancer, and the correlations between prognosis and various clinicopathological factors. We examined 174 consecutive patients who underwent curative resection of colorectal cancer, from January 2002 to December 2004. Amphiregulin was positive in 156 (90%) patients. Amphiregulin was found to be an independent predictor of overall survival [hazard ratio=6.25 (95% confidence interval=1.3-111.5; p=0.0144)] and relapse-free survival [hazard ratio=6.94 (95% confidence interval=1.5-123.2; p=0.0075)]. We conclude that the expression of Amphiregulin in a primary colorectal tumor is useful as an indicator of prognosis and as a predictor of recurrence.
Department of Surgery, Faculty of Medicine, Kurume University, Fukuoka, Japan.
Takafumi
T
Ohchi
Yoshito
Y
Akagi
Tetsushi
T
Kinugasa
Tatsuyuki
T
Kakuma
Akihiro
A
Kawahara
Teruo
T
Sasatomi
Yukito
Y
Gotanda
Keizo
K
Yamaguchi
Natsuki
N
Tanaka
Yoshiaki
Y
Ishibashi
Shingo
S
Miyamoto
Masayoshi
M
Kage
Kazuo
K
Shirouzu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066258:Amphiregulin; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D066255:EGF Family of Proteins; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models
C587848:AREG protein, human; D066258:Amphiregulin; D014408:Biomarkers, Tumor; D066255:EGF Family of Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins