A giant neuroendocrine tumor of the thymus gland causing superior vena cava syndrome.
We describe the case of a 37-year-old man with a rare giant thymic neuroendocrine tumor. The patient presented with a swelling of the neck associated with superior vena cava syndrome and underwent stent implantation in the right innominate vein (brachiocephalic vein). Computed tomography imaging revealed a large tumor of the mediastinum, measuring 15 × 10 × 12 cm. CT-guided core-needle biopsy for histology revealed a thymic carcinoid. Surgical resection of the tumor and repair with interposition of a 14-mm Gore-Tex prosthesis between the left innominate vein and the right atrial appendage were performed. Histopathological analysis classified the tumor as an atypical thymic carcinoid. Postoperative course was uneventful. Since complete resection could not be achieved, the patient received two cycles of peptide-receptor radionuclide therapy followed by conventional radiotherapy, and remains symptom-free at 12 months after surgery.
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. satsuki@dhzb.de
Satsuki
S
Komoda
Takeshi
T
Komoda
Christoph
C
Knosalla
Marianne E
ME
Pavel
Lars
L
Morawietz
Ludwig Fischer
LF
von Weikersthal
Hans B
HB
Lehmkuhl
Roland
R
Hetzer
D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D035583:Rare Diseases / Q000150:complications* / Q000473:pathology; D015607:Stents; D013479:Superior Vena Cava Syndrome / Q000209:etiology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology; D047368:Tumor Burden