Successful treatment of brain ischemia with supplementation therapy in a patient with hyperhomocysteinemia.
The effectiveness of homocysteine-lowering therapy on stroke prevention is still unclear. Although randomized controlled epidemiological trials have yielded mixed findings, a multicenter trial did not show any beneficial effect. Genetic studies are still lacking. Therefore, we report on a female patient with transient ischemic attacks and the thermolabile variant of methylenetetrahydrofolate reductase (TT genotype), who benefited from supplemental therapy for homocysteine lowering.
University Department of Neurology, Ljubljana University Clinical Center, Ljubljana, Slovenia. marjan.zaletel@kclj.si
Marjan
M
Zaletel
Ales
A
Ambrozic
Natasa
N
Gaspersic
Matija
M
Zupan
Bojana
B
Zvan
D000328:Adult; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D002546:Ischemic Attack, Transient / Q000150:complications*; D014803:Vitamin B Complex / Q000627:therapeutic use*; D014804:Vitamin B Deficiency / Q000150:complications / Q000628:therapy
D014803:Vitamin B Complex