Gastric hairballs in rabbits: significance in developmental toxicity study.
We surveyed 1053 pregnant rabbits of the Kbl:NZW strain collected from 27 developmental toxicity studies to reveal the prevalence and significance of gastric hairballs. The incidence of hairballs was 2/525 (0.4%) in the control group and 17/528 (3.2%) in the high dose group. In the high dose group, 16 dams resulted in abortion or death. In addition, decreases in body weight and food consumption were more severe in dams with hairballs than in their group-mates without hairballs.
Kannami Laboratory, Bozo Research Center Inc., Shizuoka, Japan.
Kanako
K
Fukumura
Ryo
R
Haneda
Takako
T
Endoh
Masao
M
Takano
Yasumoto
Y
Mizoguchi
Tetsuya
T
Matsuoka
Yuzo
Y
Asano
D000034:Abortion, Veterinary; D000818:Animals; D001835:Body Weight; D005247:Feeding Behavior; D005260:Female; D017219:Gastric Outlet Obstruction / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D006120:Grooming; D015994:Incidence; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D018675:Toxicity Tests