Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2.
Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA.
Niroshika
N
Keppetipola
Shalini
S
Sharma
Qin
Q
Li
Douglas L
DL
Black
D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology*; D000818:Animals; D006801:Humans; D038941:Polypyrimidine Tract-Binding Protein / Q000235:genetics / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D012322:RNA Precursors; D016601:RNA-Binding Proteins; D038941:Polypyrimidine Tract-Binding Protein