Immunological function of sphingosine 1-phosphate in the intestine.
It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. kunisawa@ims.u-tokyo.ac.jp
Jun
J
Kunisawa
Hiroshi
H
Kiyono
D000818:Animals; D004032:Diet / Q000009:adverse effects; D005502:Food / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology / Q000378:metabolism; D007410:Intestinal Diseases / Q000276:immunology*; D007422:Intestines / Q000201:enzymology / Q000276:immunology*; D008246:Lysophospholipids / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D051381:Rats; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D007070:Immunoglobulin A; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine