Occupational exposure during pregnancy and the risk of hay fever in 7-year-old children.
OBJECTIVE
The prevalence of allergic diseases including hay fever has increased in the last decades, especially in Westernised countries. The aim of this study was to analyse whether occupational exposure during pregnancy is associated with development of hay fever in 7-year-old Danish children.


METHODS
A total of 42,696 women and their children from the Danish National Birth Cohort were categorised according to maternal occupational exposure. Exposure information was obtained by combining job title in pregnancy with a commonly used asthma Job Exposure Matrix. Information on hay fever in the child was obtained by an internet questionnaire at follow-up at 7 years of age.


RESULTS
Adjusted logistic regression analyses showed no significant association between maternal occupational exposure during pregnancy and hay fever among the 7-year-old children. Stratifying for atopic status in the children did not change the results. The prevalence of hay fever was 10.0% in the atopic children compared with 3.6% in the non-atopic children. Maternal atopic disposition increased the risk of hay fever in the offspring, odds ratio (OR) 2.49 [95% confidence interval (CI) 2.26; 2.74]. Rural residence during pregnancy decreased the risk for hay fever [OR 0.74 (95% CI 0.59; 0.92)] as did parity, OR 0.72 (95% CI 0.66; 0.80) and 0.70 (95% CI 0.48; 1.00) for 2nd and 3rd child, respectively, compared with the firstborn child.


CONCLUSIONS
The results suggest that occupational exposure among pregnant women in Denmark is not a risk factor for hay fever among young children.
Section of Environmental and Occupational Medicine, Department of Public Health, Aarhus University, Aarhus, Denmark.bvch@mil.au.dk
Berit Hvass
BH
Christensen
Ane Marie
AM
Thulstrup
Karin Sørig
KS
Hougaard
Lars R
LR
Skadhauge
Kirsten Skamstrup
KS
Hansen
Vivi
V
Schlünssen
D000328:Adult; D000485:Allergens / Q000009:adverse effects / Q000032:analysis; D001249:Asthma / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D055815:Young Adult
D000485:Allergens