Synthesis of trifluoromethyl-substituted cyclopropanes via sequential Kharasch-dehalogenation reactions.
A two-step process for the synthesis of trifluoromethyl-substituted cyclopropanes is described. Halothane, an anesthetic agent, is added to olefins in a ruthenium-catalyzed Kharasch reaction. The resulting 1,3-dihalides are converted into cyclopropanes by dehalogenation with magnesium. This procedure represents an alternative to metal-catalyzed cyclopropanations involving trifluoromethyl diazomethane.
Institut des Sciences et Ingénieries Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Julie
J
Risse
Mariano A
MA
Fernández-Zúmel
Yanouk
Y
Cudré
Kay
K
Severin
D002384:Catalysis; D003521:Cyclopropanes / Q000138:chemical synthesis*; D017611:Fluorine Compounds / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure
D003521:Cyclopropanes; D017611:Fluorine Compounds; D006219:Halogens