A common genetic variant of  5p15.33 is associated with risk for prostate cancer in the Chinese population.
Recent  evidence has suggested that single-nucleotide polymorphisms (SNPs) located at  5p15.33 contribute to susceptibilities for several cancer types, including  prostate cancer. To determine whether SNP rs402710 in this region plays a role  in prostate cancer, we analyzed these associations in a Chinese population; 251  prostate cancer patients and 273 control subjects were included in this  case-control study. Genotypes were determined by PCR-RFLP. We found that  subjects carrying the CC homozygote had a decreased risk for prostrate cancer  compared to those carrying TT/TC genotypes (odds ratio (OR) = 0.69, 95%  confidence interval (CI) = 0.48-0.98, P = 0.038). Compared with the TT  homozygote, subjects carrying the CC homozygote also had a decreased risk for  prostate cancer (OR = 0.71, 95%CI = 0.51-0.99, P = 0.043). We conclude that  rs402710 polymorphisms in the 5p15.33 region are associated with prostate  cancer risk in the Chinese population. Further investigations with large  cohorts and done worldwide are warranted to determine whether our findings are  detected in other populations.
Department of Anesthesiology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
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Ren
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Xu
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Chen
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Yang
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Wang
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Wang
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Wang
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Hua
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Chen
D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*