Lifting the threshold between life and death: SUMO and HDAC fine-tune HIPK2 to sense redox status.
In the current issue of Molecular Cell, de la Vega et al. (2012) propose an intriguing model for HIPK2 posttranslational modifications in response to oxidative stress, explaining how HIPK2 can possess both prosurvival as well as proapoptotic activities.
European Institute of Oncology, Department of Experimental Oncology, IFOM-IEO Campus, Milan, Italy. susanna.chiocca@ifom-ieo-campus.it
Susanna
S
Chiocca
Christian
C
Seiser