Regulation of store-operated channels by scaffold proteins in a431 cells.
Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that different types of store-operated calcium channels have different sensitivities to Homer proteins.
Institute of Cytology, Russian Academy of Sciences.
A V
AV
Shalygin
M A
MA
Ryazantseva
L N
LN
Glushankova
I B
IB
Bezprozvanny
G N
GN
Mozhayeva
E V
EV
Kaznacheyeva