[Surfactant protein D--endogenous regulator of inflammation and immune defense].
Surfactant protein D (SP-D) is a component of lung surfactant, the representative of collagen-like lectines (collectines) family. It plays one of the significant roles in innate antibody-independent immune response. Structural features of SP-D, the possibility of its influence on pathogenetic componentes of inflammatory reaction, expression of inflammatory mediators and attainment of necessary balance between control of inflammatory reaction intensity and formation of the proper response to pathogens allow to consider SP-D as a part of innate immune system of the lung and endogenous regulator of inflammatory reactions in the organism.
S V
SV
Liamina
Sh L
ShL
Shimshelashvili
I Iu
IIu
Malyshev
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008168:Lung / Q000276:immunology* / Q000378:metabolism; D011014:Pneumonia / Q000276:immunology* / Q000378:metabolism; D037663:Pulmonary Surfactant-Associated Protein D / Q000276:immunology* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism
D037663:Pulmonary Surfactant-Associated Protein D; D011971:Receptors, Immunologic; C116303:glycoprotein 340