Risk factors for primary open-angle glaucoma in South Korea: the Namil study.
OBJECTIVE
To investigate the risk factors for primary open-angle glaucoma (POAG) in the Namil study population.


METHODS
A cross-sectional, population-based epidemiological study of residents aged ≥40 years from Namil-myon, South Korea, was conducted. Fifty-five subjects with POAG and 1,409 controls were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to identify ocular and systemic factors associated with POAG.


RESULTS
Multivariate logistic regression analysis demonstrated that older age, a history of thyroid disease and higher IOP were associated with an increased risk of POAG. Subgroup analysis showed that older age (OR 1.033, 95 % CI 1.003-1.063 per year), a history of thyroid disease (OR 7.373, 95 % CI 1.407-38.636) and higher IOP (OR 1.132, 95 % CI 1.011-1.268 per mmHg) were risk factors for normal tension glaucoma (NTG, POAG with IOP ≤21 mmHg).


CONCLUSIONS
In the Namil study, higher IOP, older age and a history of thyroid disease were significant risk factors for POAG.
Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do 463-707, Korea.
Martha
M
Kim
Tae-Woo
TW
Kim
Ki Ho
KH
Park
Joon Mo
JM
Kim
D000368:Aged; D003430:Cross-Sectional Studies; D016021:Epidemiologic Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D057066:Low Tension Glaucoma / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology