Human genetic susceptibility to Candida infections.
Infections with Candida spp. have different manifestations in humans, ranging from mucosal to bloodstream and deep-seated disseminated infections. Immunocompromised patients have increased susceptibility to these types of infections, due to reduced capacity to elicit effective innate or adaptive immunity. In addition, rare and common genetic variants in the human genome have been identified that influence susceptibility to Candida infections. Genetic determinants of primary immunodeficiencies leading to chronic mucocutaneous candidiasis have been reported, and polymorphisms in genes that are known to be involved in anti-Candida host defense are associated with increased susceptibility to systemic infection. These findings have greatly increased our understanding of pathways important for anti-Candida defense in humans, and patterns of prevalence of Candida infections. In addition, these pathways may offer novel therapeutic targets for treatment. This review provides an overview of the current insights in genetic susceptibility to Candida infections and their consequences for the immune response against Candida.
Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Theo S
TS
Plantinga
Melissa D
MD
Johnson
William K
WK
Scott
Leo A B
LA
Joosten
Jos W M
JW
van der Meer
John R
JR
Perfect
Bart Jan
BJ
Kullberg
Mihai G
MG
Netea
D002175:Candida / Q000276:immunology / Q000472:pathogenicity; D002177:Candidiasis / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic