Management of experimental benign prostatic hyperplasia in rats using a food-based therapy containing Telfairia occidentalis seeds.
The usefulness of diet containing Telfairia occidentalis seeds, in managing benign prostatic hyperplasia (BPH) in rats was studied. Twenty male Wistar rats were divided into four equal groups. BPH was induced by sub-cutaneous injection of dihydrotestosterone (DHT) and estradiol valerate (ratio, 10:1) every other day for 28 days. Rats in the test group were placed on the test diet for 7 days following disease induction. One control group (DC) was fed on a normal diet for 7 days following disease induction. Two other control groups, HC and HDC, were given sub-cutaneous olive oil (vehicle) for the same duration, and placed on the test diet and normal diet, respectively. Markers of BPH, and hormone profile were determined using standard methods. The results show that relative prostate weight and protein content of the prostates were lower [albeit not significantly (p>0.05)] in the test group, relative to the DC group. Serum prostatic acid phosphatase concentrations (U/L) decreased significantly (p<0.05) from 2.9 ± 0.2 in the DC group to 2.1 ± 0.7 in the test group. Histological findings corroborate these data. The testosterone: estradiol ratio (× 10(3)) was increased from 4.0 ± 0.2 in the DC group to 4.6 ± 0.2 in the test group. The test diet reduced the mass and secretory activity of the enlarged prostate and may act by increasing the testosterone: estradiol ratio.
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Nigeria. ejike.nonso@mouau.edu.ng
Chukwunonso E C C
CE
Ejike
Lawrence U S
LU
Ezeanyika
D000135:Acid Phosphatase; D000818:Animals; D028464:Cucurbita / Q000737:chemistry*; D013196:Dihydrotestosterone / Q000009:adverse effects / Q000097:blood; D019468:Disease Management; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009549:Nigeria; D009929:Organ Size; D010936:Plant Extracts / Q000627:therapeutic use*; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D017027:Protein Tyrosine Phosphatases; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry* / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D010936:Plant Extracts; D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases