NK cells, hypoxia and trophoblast cell differentiation.
Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal interface, natural killer (NK) cells and invasive trophoblast cells. Hypoxia-inducible factor (HIF) transcription factors direct cellular responses to low oxygen, influencing trophoblast lineage commitment and promoting development of the invasive trophoblast lineage. This short review focuses on role of NK cells on uterine spiral artery development and subsequent modulation of oxygen tensions at the maternal fetal interface.
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA.
Damayanti
D
Chakraborty
M A Karim
MA
Rumi
Michael J
MJ
Soares
D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D000860:Hypoxia; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology* / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins