Not all autophagy is equal.
Autophagy is an important mechanism in cancer cell survival and tumor growth and plays both pro- and anti-oncogenic roles. However, the biochemical basis for these diverse functions is not well understood. Our work provides new evidence for the existence of two separate autophagic programs regulated in an opposite manner by the von Hippel-Lindau tumor suppressor (VHL). These programs, marked by differential requirements for LC3B vs. LC3C, play tumor-promoting and tumor-suppressing roles in renal cancer.
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Maria.Czyzykkrzeska@uc.edu
Maria F
MF
Czyzyk-Krzeska
Jarek
J
Meller
David R
DR
Plas
D000818:Animals; D001343:Autophagy / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics*
D035683:MicroRNAs; D008869:Microtubule-Associated Proteins; D051794:Von Hippel-Lindau Tumor Suppressor Protein