Myostimulating effect of sesamum radiatum aqueous leaf extract in isolated Guinea-pig Taenia caeci contractile activity.
This study was carried to examine the effects of the aqueous leaf extract of Sesamum radiatum, a laxative plant on the contractile activity of Taenia caeci, an intestinal smooth muscle. Strips of Taenia caeci were rapidly removed from guinea-pig and were suspended between two L-shaped stainless steel hooks in a 10 ml organ bath with Mac Ewen solution. The isometric contractile force of the Taenia caeci strips were recorded by using a strain gauge. S. radiatum aqueous leaf extract (ESera) is a spasmogenic substance. This myostimulant effect is characterized by the increase of the rhythm and the amplitude of isolated guinea-pig Taenia caeci smooth muscle in normal solution and by the development of contracture in modified solution and in solution without calcium. A similar effect was observed with ACh which caused a graded increase of the contractile activity of Taenia caeci. The effects induced by ESera and ACh were reversed in the presence of atropine. The spasmogenic effect induced by ESera could justify partially the use of S. radiatum as laxative in traditional medicine.
Laboratoire de Nutrition et Pharmacologie, Département BA-PA, UFR-Biosciences, Université de Cocody, 22 BP 582 Abidjan 22, Côte d'Ivoire. andre.konan@univ-cocody.ci
André B
AB
Konan
Augustin K
AK
Amonkan
Marie-Louise B
ML
Ahui
Guy-Marcel K
GM
Bouafou
Léandre K
LK
Kouakou
Fidèle Z
FZ
Kpahé
Jacques Y
JY
Datté
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002432:Cecum / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D018727:Muscarinic Antagonists; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011188:Potassium / Q000494:pharmacology; D031685:Sesamum / Q000737:chemistry*
D018727:Muscarinic Antagonists; D010936:Plant Extracts; D001285:Atropine; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium