Low prevalence of renal, cardiac, pulmonary, and neurological extra-articular clinical manifestations in spondyloarthritis: analysis of the Brazilian Registry of Spondyloarthritis.
OBJECTIVE
To describe the extra-articular manifestations (cardiac, renal, pulmonary, and neurological), usually not related to spondyloarthritis (SpA), in a large cohort of Brazilian patients.


METHODS
This retrospective study analyzed 1,472 patients diagnosed with SpA and cared for at 29 health care centers distributed in the five major geographic regions in the country, participating in the Brazilian Registry of Spondyloarthritis (BRS). All patients were assessed for the prevalence of major extra-articular manifestations (cardiac, renal, pulmonary, and neurological), classified according to the diagnosis [ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease (IBD), undifferentiated spondyloarthritis (uSpA), and juvenile SpA], and according to the clinical presentation (axial, peripheral, mixed, and enthesitis).


RESULTS
Of the patients with SpA assessed, 963 had AS, 271 PsA, 49 ReA, 48 arthritis associated with IBD, 98 uSpA, and 43 juvenile SpA. Cardiac involvement was reported in 44 patients (3.0%), pulmonary involvement in 19 (1.3%), renal involvement in 17 (1.2%), and neurological involvement in 13 patients (0.9%). Most patients with visceral involvement had AS or PsA, and the mixed (axial + peripheral) and/or predominantly axial clinical form.


CONCLUSIONS
Cardiac, renal, pulmonary, and neurological extra-articular manifestations are quite infrequent in SpA, ranging from 0.9% to 3% in this large Brazilian cohort, and affected predominantly patients with AS and PsA.
Universidade de Fortaleza. carlosewerton@hotmail.com
Carlos Ewerton Maia
CE
Rodrigues
Walber Pinto
WP
Vieira
Adriana B
AB
Bortoluzzo
Célio Roberto
CR
Gonçalves
José Antonio Braga
JA
da Silva
Antonio Carlos
AC
Ximenes
Manoel B
MB
Bértolo
Sandra L E
SL
Ribeiro
Mauro
M
Keiserman
Rita
R
Menin
Thelma L
TL
Skare
Sueli
S
Carneiro
Valderílio F
VF
Azevedo
Elisa N
EN
Albuquerque
Washington A
WA
Bianchi
Rubens
R
Bonfiglioli
Cristiano
C
Campanholo
Hellen M S
HM
Carvalho
Izaias P
IP
Costa
Angela P
AP
Duarte
Charles L
CL
Kohem
Nocy H
NH
Leite
Sonia A L
SA
Lima
Eduardo S
ES
Meirelles
Ivânio A
IA
Pereira
Marcelo M
MM
Pinheiro
Elizandra
E
Polito
Gustavo G
GG
Resende
Francisco Airton C
FA
Rocha
Mittermayer B
MB
Santiago
Maria de Fátima L C
Mde F
Sauma
Valeria
V
Valim
Percival D
PD
Sampaio-Barros
D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006331:Heart Diseases / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology*; D008171:Lung Diseases / Q000453:epidemiology* / Q000209:etiology*; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology*; D015995:Prevalence; D000091402:Prohibitins; D012042:Registries; D012189:Retrospective Studies; D025241:Spondylarthritis / Q000150:complications* / Q000175:diagnosis