Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension.
Neonatal hyperthyroidism is a rare condition caused either by transplacental passage of thyroid-stimulating immunoglobulins from a mother with Graves' disease or by activating mutations of the thyrotropin receptors and α-subunit of G-protein. The clinical features may vary. We report a case of neonatal thyrotoxicosis in an infant born to a mother with Graves' disease, who presented with cardiorespiratory failure and persistent pulmonary hypertension (PPHN). PPHN resolved with specific antithyroid treatment and extracorporeal membrane oxygenation was not required.
The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit Medical Center, Children's Hospital of Michigan, Detroit, Michigan, USA.
Rawad
R
Obeid
Vaneet Kumar
VK
Kalra
Prem
P
Arora
Felix
F
Quist
Kathleen C
KC
Moltz
Nitin Shashikant
NS
Chouthai
D013956:Antithyroid Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D011669:Pulmonary Wedge Pressure; D013971:Thyrotoxicosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology
D013956:Antithyroid Agents