High sensitive troponin T in individuals with chest pain of presumed ischemic origin.
This study was aimed at assessing the bias of high sensitive cardiac troponin T vs. the standard cardiac troponin T in a selected population with chest pain of presumed cardiac origin. Serum cTnT was determined in 132 patients and in 106 apparently healthy controls by both assays. The hs-cTnT outperformed the standard generation assay by: i) allowing a larger and earlier diagnosis of AMI (74.2 percent vs. 64.3 percent patients resulted positive at the final diagnosis of AMI when tested with the hs-cTnT or the std-cTnT assay, respectively); ii) showing a better time-dependent dynamics in patients with AMI due to a higher precision at low concentrations; iii) identifying, within the controls, 6 subjects in whom a further examination revealed the presence of chronic asymptomatic cardiac ischemia. The results underscore the excellent performance of the hs-cTnT assay in our population. The use of this test can thus be strongly recommended in subjects presenting to the emergency unit with chest pain of presumed ischemic origin in order to increase the probability of earlier diagnosis of AMI, especially in non-STEMI.
Laboratory of Clinical Biochemistry and Molecular Biology, Fondazione, T. Campanella, University of Magna Graecia, Catanzaro, Italy. cuda@unicz.it
Giovanni
G
Cuda
Margherita
M
Lentini
Luigia
L
Gallo
Fortunata G
FG
Lucia
Lorenzina
L
Giacinto Carinci
Serafina
S
Mancuso
Rosa A
RA
Biondi
Raffaella
R
Sinopoli
Rita
R
Casadonte
Pietro H
PH
Guzzi
Mario
M
Cannataro
Annalisa
A
Mongiardo
Claudio
C
Iaconetti
Angela
A
Bochicchio
Antonio
A
Curcio
Daniele
D
Torella
Pietroantonio
P
Ricci
Ciro
C
Indolfi
Francesco
F
Costanzo
D000368:Aged; D002637:Chest Pain / Q000097:blood*; D005260:Female; D006801:Humans; D057230:Limit of Detection; D008297:Male; D008875:Middle Aged; D020107:Troponin T / Q000097:blood*
D020107:Troponin T