Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells.
A new class of hybrid chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.
Organic Chemistry Division-II, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
M
M
Nagaraju
E
E
Gnana Deepthi
C
C
Ashwini
M V P S
MV
Vishnuvardhan
V
V
Lakshma Nayak
Rajesh
R
Chandra
S
S
Ramakrishna
B B
BB
Gawali
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002599:Chalcone / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002599:Chalcone