Complex network analysis in microbial systems: theory and examples.
An essential idea in the area of Systems Biology is that a good understanding of interactions between components is crucial for developing deep knowledge of the functioning of the system as a whole. Network analysis is an approach uniquely suited to uncover patterns and organizing principles in a wide variety of complex systems. In this chapter, we will give a detailed description of central network concepts and their algorithmic implementation, and demonstrate how they may be applied on two biological networks: the protein-interaction network of Mus musculus and the reconstructed genome-scale metabolic network of the bacterium Yersinia pestis.
Department of Biotechnology, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Zahra
Z
Zavareh
Eivind
E
Almaas
D000465:Algorithms; D053858:Metabolic Networks and Pathways / Q000502:physiology; D025941:Protein Interaction Mapping; D049490:Systems Biology / Q000379:methods*