Systemic sarcoidosis with caseating granuloma.
Sarcoidosis is a multi-systemic disease, the diagnosis of which depends on the presence of non-necrotising granulomas in a biopsy specimen. However, variants such as necrotising sarcoid granuloma make it difficult to differentiate the disease from other infectious processes, especially tuberculosis. Here the authors describe the case of a 58-year-old Iranian woman who developed granulomas with extensive necrosis in a systemic sarcoidosis that affected the lung, liver and spleen. These findings led to a diagnosis of tuberculosis and delayed appropriate treatment.
Pathology Department, Shahid Sadoghi University, Yazd, Islamic Republic of Iran. binesh44@yahoo.com
Fariba
F
Binesh
Hassan
H
Halvani
Hossein
H
Navabii
D001706:Biopsy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D013158:Splenic Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D011241:Prednisone