[Osmoregulatory reactions of frog erythrocytes under conditions of activation and blockade of Ca2+-channels].
The kinetics of cell osmoregulatory reactions under conditions of activation and blockade of Ca2+-channels was studied on a model of frog polyfunctional nuclear erythrocyte. Both activation and blockade of Ca2+-channels has been established to promote swelling of nuclei and an increase of the nuclear-cytoplasmic ratios under conditions of hypotonic exposure. The osmoregulatory cell reactions after activation of Ca2+-channels are expressed as a decrease of the cell volume. The blockator of Ca2+-channels verapamil produces an alternated increase and decrease of the erythrocyte volume with time intervals of 30 and 60 s. The clearly expressed functional activity of the nuclear membrane in response to the hypotonic action under conditions of activation and blockade of Ca2+-channels indicates participation of Ca2+ ions in mechanisms of the nuclear-cytoplasmic transfer.
M Iu
MIu
Skorkina
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D002467:Cell Nucleus / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D011895:Rana ridibunda / Q000502:physiology*; D013499:Surface Properties; D014700:Verapamil / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D015220:Calcium Channels; D014700:Verapamil; D002118:Calcium