Decreased endothelial progenitor cells and increased serum glycated albumin are independently correlated with plaque-forming carotid artery atherosclerosis in type 2 diabetes patients without documented ischemic disease.
BACKGROUND
The aim of the present study was to investigate the serum levels of endothelial progenitor cells (EPCs) in type 2 diabetic patients without documented ischemic disease and the association between EPCs and atherosclerotic plaque formation in the carotid artery.


RESULTS
A clinic-based, prospective study of type 2 diabetic patients was conducted. A total of 73 subjects were enrolled in this study after cardiac magnetic resonance imaging and ankle-brachial index measurements to exclude patients with ischemic disease. Plaque formation in the carotid artery was measured on ultrasonography. Circulating EPCs (CD34(+)/CD133(+)/CD309(+) cells) were counted on flow cytometry. Compared to subjects without carotid artery plaques, patients with plaques were significantly older (P=0.006) and had decreased EPC count (P=0.027). Serum glycated albumin (GA) level and the GA/glycated hemoglobin ratio tended to decrease in patients with plaques (P=0.091 and 0.067, respectively). Other cardiovascular disease risk factors were not significantly different between the 2 groups. On binary logistic regression analysis old age, low EPC count, and high serum GA level were independently correlated with carotid artery plaque formation.


CONCLUSIONS
EPC count and serum GA level appear to be a protective and an aggravating factor for endothelial damage, respectively, and therefore, a reduced EPC count or an increased GA level results in atherosclerotic plaque formation in type 2 diabetic patients.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea.
Jae Hoon
JH
Moon
Min Kyung
MK
Chae
Kwang Joon
KJ
Kim
Hyun Min
HM
Kim
Bong Soo
BS
Cha
Hyun Chul
HC
Lee
Young Jin
YJ
Kim
Byung-Wan
BW
Lee
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D042783:Endothelial Cells; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000209:etiology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism*; D013234:Stem Cells; D000093423:Glycated Serum Albumin
D015703:Antigens, CD; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin