[The role of oxidative stress in the pathogenesis of polycystic ovary syndrome].
OBJECTIVE
To investigate the role of oxidative stress in pathogenesis of polycystic ovary syndrome (PCOS), especially in the obese PCOS.


METHODS
43 PCOS patients with BMI > or = 23 kg/m2 were grouped into PCOS1. 42 PCOS patients with BMI < 23 kg/m2 were grouped into PCOS2. Meanwhile, 85 infertility patients with normal endocrine function and body weight were grouped into control group. All patients were subjected to the measurement of serum levels of superoxide dismutase (SOD), 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) and visfatin. The difference among PCOS1, PCOS2 and control group were compared and the relationships between the indexes were analyzed with simple liner regression analysis.


RESULTS
The serum level of SOD in PCOS1 and PCOS2 were lower than that in the control group (P < 0.05), and the serum level of SOD in PCOS1 was lower than that in PCOS2 (P < 0.05). The serum levels of 8-iso-PGF2alpha and visfatin in PCOS1 were higher than those in PCOS2 and control group (P < 0.05). The serum levels of 8-iso-PGF2alpha and visfatin between PCOS2 and control group were not statistical different. In PCOS1 and PCOS2 groups, SOD activity decreased with increasing levels of 8-iso-PGF2alpha, the regression coefficient was -0.407. For serum vifation, there were positive correlations with both BMI and 8-iso-PGF2alpha, but negative correlation with SOD; the coefficients were 0. 402 (P = 0.008), 0.612 (P = 0.000), and -0.153 (P = 0.000), respectively. The indexes mentioned above did not have the liner relationship in the control group.


CONCLUSIONS
There was oxidative stress in PCOS patients, which was not obvious in the normal weight PCOS patients but quite severe in the obese PCOS patients.
Department of Reproductive Endocrinology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Jin
J
Liu
Dan
D
Zhang
D000293:Adolescent; D000328:Adult; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009765:Obesity / Q000150:complications*; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000209:etiology*; D012044:Regression Analysis; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D013482:Superoxide Dismutase; D054409:Nicotinamide Phosphoribosyltransferase