Body composition and skeletal health: too heavy? Too thin?
The relationship between body composition and skeletal metabolism has received growing recognition. Low body weight is an established risk factor for fracture. The effect of obesity on skeletal health is less well defined. Extensive studies in patients with anorexia nervosa and obesity have illuminated many of the underlying biologic mechanisms by which body composition modulates bone mass. This review examines the relationship between body composition and bone mass through data from recent research studies throughout the weight spectrum ranging from anorexia nervosa to obesity.
BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. afaje@partners.org
Alexander
A
Faje
Anne
A
Klibanski
D000273:Adipose Tissue / Q000378:metabolism*; D000856:Anorexia Nervosa / Q000503:physiopathology; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D006801:Humans; D009765:Obesity / Q000503:physiopathology; D012307:Risk Factors