The role of Eph receptors in lens function and disease.
Cataract is the single largest contributor to blindness in the world, with the disease having a strong genetic component. In recent years the Eph family of receptor tyrosine kinases has been identified as a key regulator in lens clarity. In this review we discuss the roles of the Eph receptors in lens biology and cataract development.
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Alexander I
AI
Son
Jeong Eun
JE
Park
RenPing
R
Zhou
D000818:Animals; D005128:Eye Diseases / Q000503:physiopathology*; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D051379:Mice; D036082:Receptor, EphA1 / Q000502:physiology*
D036082:Receptor, EphA1