The mammalian microRNA response to bacterial infections.
MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression. In addition to their involvement in a wide range of physiological and pathological processes, including viral infections, microRNAs are increasingly implicated in the eukaryotic response to bacterial pathogens. Recent studies have characterized changes in host microRNA expression following infection with exclusively extracellular (Helicobacter pylori) or intracellular (Salmonella enterica) Gram-negative bacteria, as well as in the response to Gram-positive (Listeria monocytogenes) and other pathogens (Mycobacterium and Francisella species). In this review, we discuss the emerging roles of microRNAs in mammalian host signaling and defense against bacterial pathogens.
Institute for Molecular Infection Biology (IMIB) and Research Centre for Infection Diseases (ZINF), University of Würzburg, Würzburg, Germany.
Ana
A
Eulalio
Leon
L
Schulte
Jörg
J
Vogel
D000818:Animals; D001424:Bacterial Infections / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D006094:Gram-Positive Bacteria / Q000276:immunology / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012475:Salmonella / Q000276:immunology / Q000502:physiology
D035683:MicroRNAs