Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study.
OBJECTIVE
To evaluate sleep disturbances or sleep related events and their characteristics among patients with medically refractory epilepsy, compared to those with controlled epilepsy.


METHODS
In a prospective case-controlled study, patients of medically refractory and controlled epilepsy were recruited and history pertaining to epilepsy and sleep related events and Epworth sleepiness scores were recorded and all patients underwent over night polysomnography.


RESULTS
Among 40 patients, 20 with medically refractory (Group 1) and 20 with controlled epilepsy (Group 2) (median age 18, range 10-35 years), the self reported sleep parameters in Group 1 patients were found to be significantly different as compared to Group 2, in terms of the duration of night time sleep, day time sleep, day time nap frequency, total sleep hours per day, excessive daytime sleepiness (EDS)(45% vs. 15%) and average sleep hours over the week prior to polysomnography. On PSG, Group 1 patients showed significantly less total sleep time [340.4 min (147-673) vs. 450.3 min (330-570)] with delayed sleep latency and REM latency, poor sleep efficiency [80.45 (40.5-98.0) vs. 95.45 (88.4-99.7)] and frequent arousals and wake after sleep onset (WASO) compared to Group 2 patients. Four patients (20%) in Group 1 compared to none in Group 2 were found to have mild obstructive sleep apnea.


CONCLUSIONS
Our results indicate that medically refractory epilepsy patients believe that they spend more time sleeping, in contrast to the documented shorter sleep duration on polysomnography. This difference between perceived and actual sleep seems, by their data, to arise mainly from sleep fragmentation, disturbed architecture and the interesting finding of associated sleep apnea among the medically refractory epilepsy patients.
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Paresh
P
Zanzmera
Garima
G
Shukla
Anupama
A
Gupta
Hariom
H
Singh
Vinay
V
Goyal
Achal
A
Srivastava
Madhuri
M
Behari
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D012890:Sleep; D012893:Sleep Wake Disorders / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult
D000927:Anticonvulsants