Intraventricular rituximab and systemic chemotherapy for treatment of central nervous system post-transplant lymphoproliferative disorder after kidney transplantation.
PTLD of the CNS is a rare complication of solid organ transplantation, and there are only case reports/series available in the literature. Current literature suggests that CNS PTLD carries a worse prognosis than PTLD outside the CNS, and most are of B-cell lineage, predominantly monomorphic, and are associated with EBV infection. Because this disorder is so rare, there is no standard chemotherapy for pediatric patients with CNS PTLD and reported therapies for EBV-associated CNS PTLD are heterogeneous with mixed results. Since outcomes of CNS PTLD are historically poor, we attempted to develop a novel therapeutic treatment regimen. Based on a review of the literature and with the help of a multidisciplinary team, we created a regimen of chemotherapy that included dexamethasone and high-dose methotrexate in addition to intravenous and intraventricular Rituximab in two pediatric patients. The intraventricular chemotherapy succeeded in shrinking the tumor in both of our patients; however, as shown in the second case, the clinical outcome depends on the location of the tumor. Systemic and intraventricular therapies hold promise in the management of EBV-associated CNS PTLD; however the rarity of this entity prevents the development of well-designed studies necessary for the establishment of an evidence-based treatment standard.
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Katherine
K
Twombley
Hanumantha
H
Pokala
Monica I
MI
Ardura
Paul
P
Harker-Murray
Sarah F
SF
Johnson-Welch
Arthur
A
Weinberg
Mouin
M
Seikaly
D000293:Adolescent; D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage*; D001402:B-Lymphocytes / Q000166:cytology; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000188:drug therapy; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D057967:Infusions, Intraventricular; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008232:Lymphoproliferative Disorders / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D011183:Postoperative Complications; D011379:Prognosis; D000069283:Rituximab; D012640:Seizures; D016896:Treatment Outcome
D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab; D003907:Dexamethasone; D008727:Methotrexate