Intra-operatively customized implant coating strategies for local and controlled drug delivery to bone.
Bone is one of the few tissues in the human body with high endogenous healing capacity. However, failure of the healing process presents a significant clinical challenge; it is a tremendous burden for the individual and has related health and economic consequences. To overcome such healing deficits, various concepts for a local drug delivery to bone have been developed during the last decades. However, in many cases these concepts do not meet the specific requirements of either surgeons who must use these strategies or individual patients who might benefit from them. We describe currently available methods for local drug delivery and their limitations in therapy. Various solutions for drug delivery to bone focusing on clinical applications and intra-operative constraints are discussed and drug delivery by implant coating is highlighted. Finally, a new set of design and performance requirements for intra-operatively customized implant coatings for controlled drug delivery is proposed. In the future, these requirements may improve approaches for local and intra-operative treatment of patients.
Julius Wolff Institute, Charité-Universitätsmedizin Berlin, Berlin, Germany. branko.trajkovski@charite.de
Branko
B
Trajkovski
Ansgar
A
Petersen
Patrick
P
Strube
Manav
M
Mehta
Georg N
GN
Duda
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000008:administration & dosage*; D004867:Equipment Design; D004864:Equipment and Supplies; D006801:Humans; D007430:Intraoperative Care / Q000379:methods
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004343:Drug Implants