Low-dose radiation exposure and carcinogenesis.
Absorption of energy from ionizing radiation by the genetic material in the cell leads to damage to DNA, which in turn leads to cell death, chromosome aberrations and gene mutations. While early or deterministic effects result from organ and tissue damage caused by cell killing, latter two are considered to be involved in the initial events that lead to the development of cancer. Epidemiological studies have demonstrated the dose-response relationships for cancer induction and quantitative evaluations of cancer risk following exposure to moderate to high doses of low-linear energy transfer radiation. A linear, no-threshold model has been applied to assessment of the risks resulting from exposure to moderate and high doses of ionizing radiation; however, a statistically significant increase has hardly been described for radiation doses below 100 mSv. This review summarizes our current knowledge of the physical and biological features of low-dose radiation and discusses the possibilities of induction of cancer by low-dose radiation.
Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Keiji
K
Suzuki
Shunichi
S
Yamashita
D000367:Age Factors; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000528:radiation effects*; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations / Q000528:radiation effects; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology; D018499:Linear Energy Transfer; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D054043:Nuclear Weapons; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D017741:Survivors / Q000706:statistics & numerical data; D013961:Thyroid Gland / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology*