Radical one-pot α,β-dual and β-mono-oxymethylation of alkylidenemalonate.
Dimethylzinc-mediated radical conjugate addition reaction of dimethyl alkylidenemalonates with iodomethyl pivalate gave a high yield of the α,β-dual oxymethylation product in one pot under air and the β-pivaloyloxymethylation product under argon.
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo, Kyoto 606-8501, Japan. yamak@pharm.kyoto-u.ac.jp
Ken-ichi
K
Yamada
Takehito
T
Konishi
Mayu
M
Nakano
Shintaro
S
Fujii
Romain
R
Cadou
Yasutomo
Y
Yamamoto
Kiyoshi
K
Tomioka
D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure
D005609:Free Radicals; D008314:Malonates