The predictive value of plasma cystatin C for acute coronary syndrome treated with percutaneous coronary intervention.
BACKGROUND
This study was designed to evaluate the value of plasma cystatin C in predicting adverse cardiac events after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).


METHODS
A total of 605 patients (404 male, mean age 60.4 ± 10.6 years) with ACS underwent successful PCI. Patients were divided into 4 groups according to the level of cystatin C, which was measured before the PCI: Q1 (<1.02 mg/L), Q2 (1.02-1.16 mg/L), Q3 (1.17-1.34 mg/L), and Q4 (≥1.35 mg/L).


RESULTS
After a follow-up of 14.3 ± 1.7 months, the incidence of mortality, nonfatal myocardial infarction, and target lesion revascularization in the Q2, Q3, and Q4 groups was higher than in the Q1 group (P < .001). The incidence of heart failure in the Q3 and Q4 groups was higher than in the Q1 group (P < .05). Multivariate Cox regression analysis showed that cystatin C elevation was an independent predictor of major adverse cardiac events. The cumulative survival rate of the Q3 and Q4 groups was lower than in the Q1 group (P < .001).


CONCLUSIONS
High plasma cystatin C concentration is an independent predictor of major adverse cardiac events in patients with ACS treated with PCI.
Department of Integrated ICU, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.
Tong-Wen
TW
Sun
Qing-Yan
QY
Xu
Hai-Mu
HM
Yao
Xiao-Juan
XJ
Zhang
Qiong
Q
Wu
Jin-Ying
JY
Zhang
Ling
L
Li
Yan-Zhou
YZ
Zhang
Quan-Cheng
QC
Kan
Fang-Xia
FX
Guan
Le-Xin
LX
Wang
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D055316:Cystatin C / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index
D015415:Biomarkers; D055316:Cystatin C