Antimicrobial therapy of febrile complications after high-dose chemotherapy and autologous hematopoietic stem cell transplantation--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).
More than 18,000 autolgous transplantation were performed in Europe in the year 2009. It as a routine procedure in experienced centres. Even if there is a low mortality rate, infections are a major issue after transplantation, occurring in more than 60 % of the patients. In this review we discuss all aspects of infections after autologous stem transplantation, including epidemiology, diagnostics, therapeutic algorithms, prophylaxis and supportive therapy.
Klinik für Innere Medizin, Hämatologie/Onkologie und Palliativmedizin, Evangelisches Krankenhaus Bielefeld, Schildescher Str. 99, 33611 Bielefeld, Germany. Florian.Weissinger@evkb.de
Florian
F
Weissinger
Holger W
HW
Auner
Hartmut
H
Bertz
Dieter
D
Buchheidt
Oliver A
OA
Cornely
Gerlinde
G
Egerer
Werner
W
Heinz
Meinolf
M
Karthaus
Michael
M
Kiehl
William
W
Krüger
Olaf
O
Penack
Stefan
S
Reuter
Markus
M
Ruhnke
Michael
M
Sandherr
Hans-Jürgen
HJ
Salwender
Andrew J
AJ
Ullmann
Dirk T
DT
Waldschmidt
Hans H
HH
Wolf
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D003141:Communicable Diseases / Q000188:drug therapy* / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000188:drug therapy*; D005858:Germany; D006405:Hematology / Q000331:legislation & jurisprudence / Q000458:organization & administration; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000706:statistics & numerical data; D006801:Humans; D008495:Medical Oncology / Q000331:legislation & jurisprudence / Q000458:organization & administration; D009787:Occupational Medicine / Q000331:legislation & jurisprudence / Q000458:organization & administration; D017410:Practice Guidelines as Topic; D012955:Societies, Medical; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000706:statistics & numerical data
D000890:Anti-Infective Agents