C-reactive protein and procalcitonin during febril attacks in PFAPA syndrome.
OBJECTIVE
To assess the levels of procalcitonin (PCT) and C-reactive protein (CRP) in children diagnosed with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) during their febrile attacks.


METHODS
23 patients with diagnosis of PFAPA included into the study prospectively during a three years period. In these patients, CRP and PCT values were recorded during 78 febrile episodes. Furthermore, 20 patients with diagnosis of pneumonia were chosen as a control group and their CRP and PCT values were measured. Normal reference values for CRP and PCT were 0-10 mg/L and 0-0.5 ng/mL, respectively.


RESULTS
Mean CRP and PCT values of patients with PFAPA were 94.8±71.6 mg/L and 0.29±0.14 ng/mL, respectively. In control group, mean CRP value was 153.2±26 mg/L and PCT was 1.59±0.53 ng/mL. CRP and PCT were high in control group. CRP was detected high and PCT was normal in PFAPA. Compared to control group, in PFAPA group, CRP values were not significantly (p>0.05) and PCT values were significantly lower (p<0.001).


CONCLUSIONS
During febrile episodes in the patients with diagnosis of PFAPA, CRP values were substantially elevated, whereas PCT values were within normal levels. Concomitant assessment of CRP and PCT in addition to clinical diagnostic criteria may be of help in making diagnosis and distinguishing febrile attacks from infections. However, studies in larger groups are required.
Dept of Pediatrics, Sema Hospital, Turkey. hyazgan@semahastanesi.com.tr
Hamza
H
Yazgan
Esengül
E
Keleş
Zerrin
Z
Yazgan
Arzu
A
Gebeşçe
Mehmet
M
Demirdöven
D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D005260:Female; D056660:Hereditary Autoinflammatory Diseases / Q000097:blood*; D006801:Humans; D008199:Lymphadenitis / Q000097:blood; D008297:Male; D010612:Pharyngitis / Q000097:blood; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D013281:Stomatitis, Aphthous / Q000097:blood; D013577:Syndrome
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide