A historical perspective on sepsis.
In North America, approximately 700,000 cases of sepsis occur each year, with mortality ranging between 30% and 50%. The American Journal of Pathology has featured numerous articles on the topic, revealing mechanistic insights gleaned from both experimental rodent models and human sepsis. Nonetheless, there remains urgent need to determine the basis for sepsis-related complications and how they can be avoided, as well as how they can be most effectively treated once recognized. This historical perspective reviews what we currently understand about the mechanisms of sepsis, as well as the barriers that remain in our treatment strategies.
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-5602, USA. pward@med.umich.edu
Peter A
PA
Ward
Markus
M
Bosmann
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D012377:Rodentia; D018805:Sepsis / Q000150:complications / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome