A toy model of fractal glioma development under RF electric field treatment.
A toy model for glioma treatment by a radio frequency electric field is suggested. This low-intensity, intermediate-frequency alternating electric field is known as the tumor-treating field (TTF). In the framework of this model the efficiency of this TTF is estimated, and the interplay between the TTF and the migration-proliferation dichotomy of cancer cells is considered. The model is based on a modification of a comb model for cancer cells, where the migration-proliferation dichotomy becomes naturally apparent. Considering glioma cancer as a fractal dielectric composite of cancer cells and normal tissue cells, a new effective mechanism of glioma treatment is suggested in the form of a giant enhancement of the TTF. This leads to the irreversible electroporation that may be an effective non-invasive method of treating brain cancer.
Department of Physics, Technion, Haifa, Israel. iomin@physics.technion.ac.il
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Iomin
D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy; D002465:Cell Movement / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D018274:Electroporation; D017709:Fractals; D005910:Glioma / Q000473:pathology* / Q000628:therapy*; D007700:Kinetics; D055909:Magnetic Field Therapy; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D000078702:Radiofrequency Therapy; D013269:Stochastic Processes