Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones.
A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma cell line, human cervix carcinoma cell line, human hepatocellular carcinoma cell line and human keratinocyte cell line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g and 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity against a hepatocellular carcinoma cell line with IC(50) = 3.5 μg/mL and 3.0 μg/mL, respectively.
Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen campus, Nakhon Pathom, Thailand.
Weerachai
W
Phutdhawong
Gedsirin
G
Eksinitkun
Wanwikar
W
Ruensumran
Thongchai
T
Taechowisan
Waya S
WS
Phutdhawong
D002460:Cell Line; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000502:physiology; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology*
D009285:Naphthoquinones