Pulmonary function tests in patients with primary hyperparathyroidism.
BACKGROUND
There is limited information on respiratory muscle functions in patients with primary hyperparathyroidism (PHPT).


OBJECTIVE
To assess respiratory muscle dysfunction in patients with PHPT.


METHODS
This prospective study was carried between January 2005 and December 2006 by the Department of Endocrinology at the Postgraduate Institute of Medical Education and Research, Chandigarh.


METHODS
PHPT was defined as elevated parathyroid hormone in the presence of hypercalcemia. Spirometry was performed using a dry rolling seal spirometer and spirometric indices like forced vital capacity (FVC), forced expiratory volume in first second (FEV(1)), and FEV(1)/FVC ratio were measured using standard guidelines.


RESULTS
Thirty patients were studied with a mean age of 37.1 ± 2.4 years and 18 were women. The most common presenting symptoms were fatigue (75.0%) and bone pain (60.70%). The mean (±SD) of percentage predicted FVE(1), FVC, FEV(1)/FVC ratio, PEF, and FEF were 98.7 ± 16.1, 93.9 ± 14.7, 84.5 ± 3.4, 89.3 ± 22.5, and 99.7 ± 33.6, respectively. Two had obstructive lung disease and two had restrictive lung disease. We did not find correlation with preoperative serum calcium, phosphate, and PTH with FVE(1), FVC, FEV(1)/FVC ratio, PEF, and FEF.


CONCLUSIONS
Elevated calcium, low phosphate, and elevated PTH levels in patients with moderate to severe PHPT do not significantly affect respiratory muscle functions.
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh (UT), India.
Sanjay Kumar
SK
Bhadada
Ahutosh
A
Agrawal
Viral N
VN
Shah
Anil
A
Bhansali
Arnanshu
A
Behera
Anish
A
Bhattacharya
Uma
U
Nahar