The risk of acute myocardial infarction and arterial hypertension in a cohort of male employees of a Siberian Group of Chemical Enterprises exposed to long-term irradiation.
During the period from 1998 to 2007, a prospective cohort study of acute myocardial infarction morbidity cases as well as a "case-control" study of arterial hypertension was carried out. The risk of acute myocardial infarction was assessed as well as arterial hypertension; the dose-response relationship and the role of radiation in the mechanism of acute myocardial infarction as well as arterial hypertension development were studied. As a result of this study, a statistically significant increased risk of acute myocardial infarction among the male staff at the Siberian Group of Chemical Enterprises [standardized relative risk = 1.16 (1.04; 1.29)] exposed to external irradiation in comparison with employees unexposed to ionizing radiation was observed. A significant increase in the risk of acute myocardial infarction was observed at external radiation dose accumulation of more than 300 mSv [standardized relative risk = 1.46 (1.09; 1.91)]. The increase in arterial hypertension risk has been established among the analyzed group of employees exposed to long-term irradiation in the absence of the linear dependence of risk, based on cumulative dose of external γ-irradiation [risk due to external radiation dose in the range of 7.3-21.3 mSv = 1.6 (0.96; 2.51) and in the range of external radiation dose 21.4-68.5 mSv = 1.7 (1.04; 2.67) for 68.6-864 mSv = 1.6 (1.01; 2.57)]. This led to the conclusion that radiation can act also as a factor that might potentiate the negative effects of the "traditional" risk factors in the pathogenesis of acute myocardial infarction and hypertension.
Seversk Biophysics Research Center, Seversk, Russia. mail@sbrc.ru
Andrey B
AB
Karpov
Yulia V
YV
Semenova
Ravil M
RM
Takhauov
Tatyana M
TM
Litvinenko
Dmitry E
DE
Kalinkin
D000208:Acute Disease / Q000453:epidemiology; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D011832:Radiation Injuries / Q000453:epidemiology* / Q000209:etiology*; D012306:Risk; D012800:Siberia; D013997:Time Factors