MSQuant: a platform for stable isotope-based quantitative proteomics.
Quantitative approaches in proteomics are emerging as a powerful tool to probe the dynamics of protein expression across biological conditions. Thereby, quantification helps to recognize proteins with potential biological relevance, which greatly aids in the design of follow-up experiments. Although multiple methods have been established that are based on stable-isotope labeling and label-free approaches, one of the remaining bottlenecks is the analysis and quantification of proteins in large datasets. MSQuant is a platform for protein quantification, capable of handling multiple labeling strategies and supporting several vendor data formats. Here, we report on the use and versatility of MSQuant.
Department of Biochemistry and Molecular Biology, Centre for High-Throughput Biology, University of British Columbia, Vancouver, BC, Canada.
Joost W
JW
Gouw
Jeroen
J
Krijgsveld
D003627:Data Interpretation, Statistical; D001330:Electronic Data Processing; D007553:Isotope Labeling; D020543:Proteome / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics; D012984:Software
D020543:Proteome