Bioactive cadinane-type compounds from the soft coral Sinularia scabra.
Two new cadinane-type sesquiterpenoids, scabralins A (1) and B (2) were obtained from the soft coral Sinularia scabra. Metabolite 1 was shown to exhibit moderate to weak cytotoxicity against MCF-7, WiDr, Daoy, and HEp 2 cancer cell lines. Also, incubation with 10 µM compound 1 significantly inhibited the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Jui-Hsin
JH
Su
Chiung-Yao
CY
Huang
Po-Ju
PJ
Li
Yi
Y
Lu
Zhi-Hong
ZH
Wen
Yao-Haur
YH
Kao
Jyh-Horng
JH
Sheu
D000818:Animals; D037421:Anthozoa; D002460:Cell Line; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D003603:Cytotoxins; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane