Manganese(III) acetate mediated oxidative radical cyclizations. Toward vicinal all-carbon quaternary stereocenters.
Manganese(III) acetate mediated oxidative radical cyclizations have been used to synthesize a range of densely functionalized and sterically congested cyclopentane-lactones. A number of the resulting lactones contain vicinal all-carbon quaternary stereocenters adjacent to a tertiary benzylic stereocenter and are formed with high levels of stereocontrol.
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Angus W J
AW
Logan
Jeremy S
JS
Parker
Michal S
MS
Hallside
Jonathan W
JW
Burton
D000085:Acetates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000085:Acetates; D005609:Free Radicals; D009942:Organometallic Compounds; C521134:manganese(III) acetate dihydrate; D002244:Carbon