Air pollution and hospitalization for acute complications of diabetes in Chile.
Exposure to air pollution has been shown to cause insulin resistance in mice. To determine the relevance to humans, we tested the association between daily air pollution concentrations and daily hospitalization for acute serious complications of diabetes, coma and ketoacidosis, in Santiago between 2001 and 2008, using generalized linear models with natural splines to control for long term trends. For an interquartile range (IQR) increase in air pollutant, the relative risks (95% CI) of hospitalization for diabetes were: 1.15 (1.10, 1.20) for carbon monoxide (IQR=1.00); 1.07 (0.98, 1.16) for ozone (IQR=63.50); 1.14 (1.06, 1.22) for sulfur dioxide (IQR=5.88); 1.12(1.05, 1.20) for nitrogen dioxide (IQR=27.94); 1.11 (1.07, 1.15) for particulate matter≤10 μm diameter(IQR=34.00); and 1.11 (1.06, 1.16) for fine particulate matter ≤2.5 μm diameter (IQR=18.50). Results were similar when stratified by age, sex and season. Air pollution appears to increase the risk of acute complications of diabetes requiring hospitalization, suggesting that improvements in air quality may reduce morbidity from diabetes.
Health Canada, University of Ottawa Departments of Medicine and Epidemiology, The Ottawa Hospital (General Campus), 501 Smyth Road, Box 211, Ottawa, ON, K1H 8L6, Canada.
Robert E
RE
Dales
Sabit
S
Cakmak
Claudia Blanco
CB
Vidal
Maria Angelica
MA
Rubio
D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects; D000397:Air Pollution / Q000009:adverse effects*; D002248:Carbon Monoxide / Q000009:adverse effects; D002677:Chile / Q000453:epidemiology; D003128:Coma / Q000209:etiology; D048909:Diabetes Complications / Q000453:epidemiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007662:Ketosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000009:adverse effects; D010126:Ozone / Q000009:adverse effects; D052638:Particulate Matter / Q000009:adverse effects; D012307:Risk Factors; D012621:Seasons; D013458:Sulfur Dioxide / Q000009:adverse effects
D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D010126:Ozone; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide