Tumor-specific MAGE proteins as regulators of p53 function.
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
Departamento de Química Biológica, FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
María Fátima
MF
Ladelfa
Leticia Yamila
LY
Peche
María Fernanda
MF
Toledo
Julieta Eva
JE
Laiseca
Claudio
C
Schneider
Martín
M
Monte
D000818:Animals; D048708:Cell Growth Processes / Q000502:physiology; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism*; D058950:Melanoma-Specific Antigens / Q000235:genetics* / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D058950:Melanoma-Specific Antigens; D016159:Tumor Suppressor Protein p53