Vitamin K status in patients with short bowel syndrome.
OBJECTIVE
Available evidence suggests that patients with short bowel syndrome (SBS) might be at risk of vitamins A, D, E and B(1) deficiency. However, there is little clinical data describing the vitamin K status. Therefore, in the present study we aimed to assess the body resources of vitamin K in a subset of SBS patients.


METHODS
The study comprised 33 patients aged 1 month to 16 years. PIVKA-II concentrations were determined in all subjects.


RESULTS
In all studied subjects, coagulation parameters were normal. PIVKA-II levels indicative of vitamin K deficiency was found in 3 (9.1%) SBS patients. One patient had been receiving an additional intravenous vitamin K dose of 5 mg/week. In all SBS patients with cirrhosis and cholestasis, PIVKA-II concentrations were low (<2 ng/ml). However, all patients with severe liver disease were receiving vitamin K several times a month.


CONCLUSIONS
Vitamin K deficiency may appear in SBS patients.
Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Patrycja
P
Krzyżanowska
Janusz
J
Książyk
Małgorzata
M
Kocielińska-Kłos
Elżbieta
E
Banaś
Małgorzata
M
Kaleta
Katarzyna
K
Popińska
Tomasz
T
Szczapa
Jarosław
J
Walkowiak
D000293:Adolescent; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000097:blood; D008297:Male; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D012778:Short Bowel Syndrome / Q000097:blood* / Q000150:complications; D014812:Vitamin K / Q000008:administration & dosage / Q000097:blood*; D014813:Vitamin K Deficiency / Q000150:complications / Q000175:diagnosis*; D014815:Vitamins / Q000008:administration & dosage / Q000097:blood*
D000933:Antifibrinolytic Agents; D015415:Biomarkers; D011498:Protein Precursors; D014815:Vitamins; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin