Two new diterpenoids from the buds of Wikstroemia chamaedaphne.
Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P₂ (2), P₃ (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (−)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jieru
J
Guo
Jinwen
J
Zhang
Penghua
P
Shu
Lingmei
L
Kong
Xincai
X
Hao
Yongbo
Y
Xue
Zengwei
Z
Luo
Yan
Y
Li
Gao
G
Li
Guangmin
G
Yao
Yonghui
Y
Zhang
D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019906:Nuclear Magnetic Resonance, Biomolecular; D032365:Wikstroemia / Q000737:chemistry*
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C575315:prostratin Q; C575314:wikstroelide Q