Responsive electrical stimulation suppresses epileptic seizures in rats.
BACKGROUND
A responsive electrical stimulation pattern based on our recently developed novel seizure prediction method was designed to suppress the penicillin-induced epileptic seizures.


METHODS
Seizures were induced by Penicillin injection at rat cortex. A responsive electrical stimulation system was triggered prior to seizures predicted with phase synchronisation. Rats with induced seizures were stimulated by the electrical pulses at a responsive or 1 Hz periodic pattern of an open system. The effectiveness of stimulation on seizures suppression was assessed by measuring the average number and duration of seizures per hour.


RESULTS
The prediction algorithm reliably identified seizures in real time and triggered the responsive stimulation. This type of electrical stimulation dramatically suppressed seizure activity and the performance was better than the open stimulation system with fewer and shorter seizures.


CONCLUSIONS
A responsive electrical stimulation system triggered by the phase synchronisation prediction is able to significantly suppress seizures.


CONCLUSIONS
Responsive electrical stimulation could achieve superior treatment performance and reduce power consumption and side effects.
Faculty of Biomedical Engineering, the Fourth Military Medical University, Xi'an, China.
Lei
L
Wang
Heng
H
Guo
Xiao
X
Yu
Shouyan
S
Wang
Canhua
C
Xu
Feng
F
Fu
Xiaorong
X
Jing
Hua
H
Zhang
Xiuzhen
X
Dong
D000818:Animals; D002540:Cerebral Cortex; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D010406:Penicillins / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D010406:Penicillins