Patterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: a multicentric, randomised observational study in northern India.
OBJECTIVE
The aims of the study were to ascertain difference in lipid levels of 'Young' onset of coronary artery disease (CAD) (≤ 45 years) vs. 'Not so Young' onset of CAD (≥ 55 years) among north Indians and also to investigate determinants of 'dyslipidaemia' in CAD patients.


METHODS
This was a prospective, multicentric, randomised, observational study carried in eight centres of UP, India. All blood investigations were performed employing a central laboratory.


RESULTS
Out of a total 435 patients studied, 218 were in the 'young group' (YG) and 235 were in the 'Not so Young Group' (NSYG). Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG.


CONCLUSIONS
We conclude that lipid levels among north Indians are significantly higher in younger patients with CAD when compared with elderly.
Sahara India Medical Institute, Lucknow, Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. sinha.nakul@gmail.com
Nakul
N
Sinha
Sudeep
S
Kumar
Himanshu
H
Rai
Neha
N
Singh
Aditya
A
Kapoor
Satyendra
S
Tewari
R K
RK
Saran
V S
VS
Narain
R P S
RP
Bharadwaj
R K
RK
Bansal
P C
PC
Saxena
P R
PR
Sinha
P R
PR
Gupta
Mukul
M
Mishra
Praveen
P
Jain
C M
CM
Pandey
Uttam
U
Singh
S S
SS
Agarwal
D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D050171:Dyslipidemias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012307:Risk Factors