[Assessment of airway inflammation in chronic obstructive pulmonary disease: biomarkers in exhaled breath condensate].
Airway inflammation plays a central role in the pathophysiology of chronic obstructive pulmonary disease. Exposure to cigarette smoke induces the recruitment of inflammatory cells in the airways, which in turn produces various cytokines, chemokines, proteases and pro-inflammatory mediators leading ultimately to increased oxidative stress, a protease/anti-protease imbalance and progressive lung tissue injury. Biomarkers may be useful in monitoring airway inflammation and oxidative stress, defining different phenotypes of the disease and evaluating the response of therapies. Exhaled breath condensate collection is a simple and completely non-invasive method of sampling the lower respiratory tract in humans. Exhaled breath condensate may be a rich source of pulmonary biomarkers including hydrogen peroxide, cytokines, metabolites of the arachidonic acid, nitric oxides and the pH. However, the concentration of these biomarkers is often very low, which may cause several problems in their detection. The clinical applicability of exhaled breath condensate biomarkers cannot be assessed until methods of sample collection and analysis have been standardized.
Országos Korányi Tbc- és Pulmonológiai Intézet Budapest Pihenő út. antusb@hotmail.com
Balázs
B
Antus
D016718:Arachidonic Acid / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000175:diagnosis* / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000473:pathology; D012137:Respiratory System / Q000378:metabolism* / Q000473:pathology*
D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D016718:Arachidonic Acid; D009569:Nitric Oxide; D006861:Hydrogen Peroxide