Strategies for excluding false Y-chromosomal SNP entries from human genome databases.
Current human genome databases for public single nucleotide polymorphisms (SNPs) still contain a substantial fraction of false entries. The main reasons for errors include sequencing or assembly errors, paralogous sequence-, and private variants. In the course of our studies on the Y chromosome, we established a set of internal laboratory guidelines for reliably identifying false SNP entries in databases.
Department of Forensic Genetics, Institute of Legal Medicine and Forensic Sciences, Berlin, Germany. jessica.rothe@charite.de
Jessica
J
Rothe
Marion
M
Nagy
D001483:Base Sequence; D041322:Chromosomes, Human, Y; D030541:Databases, Genetic / Q000592:standards*; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000592:standards