[Erythrocyte lipid composition at different stages of type 1 diabetes in children].
Complete profiles of phospholipid and ceramide molecular species from erythrocyte lipid extracts of children without carbohydrate metabolism disorders, and children with type 1 diabetes were compared by means of high performance liquid chromatography/mass spectrometry. For the first time a statistically significant increase (p<0.05) of lysophosphatidylcholine content in two groups of diabetic children with different duration of the disease (less than one year and more than one year) was found. Statistically significant changes in other lipid classes were not observed. The dependence of the content of phosphatidylcholine and phosphatidylethanolamine molecular species containing arachidonic acid residue (20:4) on the duration of the disease was found. The observed shift in lipid metabolism suggests of phospholipase A2 and chronic inflammatory process at different stages of diabetes mellitus, in cells (erythrocytes), which aer not involved in the immune response.
V A
VA
Mitianina
V N
VN
Kuptsov
S V
SV
Savel'ev
V I
VI
Shvets
A A
AA
Selishcheva
D000293:Adolescent; D016718:Arachidonic Acid / Q000737:chemistry; D002648:Child; D002851:Chromatography, High Pressure Liquid; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000737:chemistry*; D006801:Humans; D050356:Lipid Metabolism; D008244:Lysophosphatidylcholines / Q000097:blood*; D013058:Mass Spectrometry; D008563:Membrane Lipids / Q000097:blood*; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D013997:Time Factors
D008244:Lysophosphatidylcholines; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D016718:Arachidonic Acid; C483858:phosphatidylethanolamine