Residual neuromuscular blockade in critical care.
Neuromuscular blockade is a pharmacological adjunct for anesthesia and for surgical interventions. Neuromuscular blockers can facilitate ease of instrumentation and reduce complications associated with intubation. An undesirable sequela of these agents is residual neuromuscular blockade. Residual neuromuscular blockade is linked to aspiration, diminished response to hypoxia, and obstruction of the upper airway that may occur soon after extubation. If an operation is particularly complex or requires a long anesthesia time, residual neuromuscular blockade can contribute to longer stays in the intensive care unit and more hours of mechanical ventilation. Given the risks of this medication class, it is essential to have an understanding of the mechanism of action of, assessment of, and factors affecting blockade and to be able to identify factors that affect pharmacokinetics.
Princeton Baptist Medical Center, Birmingham, AL, USA.
Jason
J
Wilson
Angela S
AS
Collins
Brea O
BO
Rowan
D003422:Critical Care; D004347:Drug Interactions; D006801:Humans; D019148:Neuromuscular Blockade / Q000451:nursing*; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects; D009730:Nursing Assessment; D013527:Perioperative Nursing; D012307:Risk Factors
D009466:Neuromuscular Blocking Agents