DroPNet: a web portal for integrated analysis of Drosophila protein-protein interaction networks.
DroPNet (Drosophila Protein Network) is a Drosophila-dedicated web portal for generating and analyzing protein-protein interaction (PPI) networks. This platform integrates users' experimental data provided as one or two lists of genes with PPI data from Drosophila and other species. These experimental data can, for example, come from RNAi screens, for which this approach is known to be valuable. DroPNet, therefore, provides an essential basis for further biological analysis by linking functional and physical interactions and reinforcing the relevance of each. DroPNet focuses on the search of PPIs between genes of the entry list, and includes the possibility of searching for intermediate genes for which the corresponding protein indirectly links two entry data. It also offers multiple functions for editing the networks obtained, providing users with interactive possibilities to progressively improve and refine the results. This approach gives a global view of the studied process and makes it possible to highlight specific interactions that have so far been understudied. DroPNet is freely available at http://dropnet.isima.fr.
GReD Laboratory, Unité Mixte de Recherche Centre National de la Recherche Scientifique 6293, Clermont Université, Institut de la Santé Et de la Recherche Médicale U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France.
Yoan
Y
Renaud
Alexandre
A
Baillif
Jean-Baptiste
JB
Perez
Marie
M
Agier
Engelbert
E
Mephu Nguifo
Vincent
V
Mirouse
D000818:Animals; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D020407:Internet; D025941:Protein Interaction Mapping / Q000379:methods*; D012984:Software; D018511:Systems Integration
D029721:Drosophila Proteins