Extracellular NAD(+): a danger signal hindering regulatory T cells.
Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals.
Inserm, U905, 22 boulevard Gambetta, F-76000 Rouen, Normandy, France. sahil.adriouch@univ-rouen.fr
Sahil
S
Adriouch
Friedrich
F
Haag
Olivier
O
Boyer
Michel
M
Seman
Friedrich
F
Koch-Nolte
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D005110:Extracellular Space / Q000276:immunology; D006801:Humans; D009243:NAD / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D009243:NAD