Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells.
Hematopoietic stem cell transplantation is the most powerful treatment modality for a large number of hematopoietic malignancies, including leukemia. Successful hematopoietic recovery after transplantation depends on homing of hematopoietic stem cells to the bone marrow and subsequent lodging of those cells in specific niches in the bone marrow. Migration of hematopoietic stem cells to the bone marrow is a highly regulated process that requires correct regulation of the expression and activity of various molecules including chemoattractants, selectins and integrins. This review will discuss recent studies that have extended our understanding of the molecular mechanisms underlying adhesion, migration and bone marrow homing of hematopoietic stem cells.
Department of Hematology and Erasmus MC Stem Cell Institute for Regenerative Medicine, Erasmus MC, Rotterdam, The Netherlands.
Aysegul Ocal
AO
Sahin
Miranda
M
Buitenhuis
D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism* / Q000502:physiology; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002448:Cell Adhesion; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D015973:Gene Expression Regulation, Leukemic; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D039441:Integrin alpha4 / Q000378:metabolism; D016023:Integrins / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D054377:Chemokine CXCL12; D039441:Integrin alpha4; D016023:Integrins; D019869:Phosphatidylinositol 3-Kinases; D000099152:Cadherin 5; C515255:CXCL12 protein, human