[Pancreas and metabolic syndrome].
The functional state of the pancreas has a significant share in the development of the basic components of MS (hyperinsulinemia, insulin resistance, impaired glucose tolerance) and, conversely, the existing metabolic changes (obesity, atherogenic dyslipidemia) contribute to the violation of the endocrine and exocrine pancreatic function. It is assumed, on the one hand, the fundamental role of fatty pancreas disease in developing metabolic syndrome, with the formation of insulin resistance, on the other hand, indicates that hyperinsulinemia, hyperglycemia and dyslipidemia, as well as microcirculatory disturbances aggravate the state of the pancreas. Trigger mechanism of progression pancreatic pathology in MS appears inflammation closely accompanied with fatty infiltration of the body against obesity. Changes in pancreas specific to MS, are not only secondary to its background, but also contribute to the progression of the syndrome and the development of complications, closing the pathogenic circle.
N G
NG
Samsonova
L A
LA
Zvenigorodskaia
D000818:Animals; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D010179:Pancreas / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D010182:Pancreatic Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology