Alpinetin/hydroxypropyl-β-cyclodextrin host-guest system: preparation, characterization, inclusion mode, solubilization and stability.
The inclusion complexation behavior, characterization and binding ability of alpinetin with hydroxypropyl-β-cyclodextrin (HPβCD) has been investigated in both solution and the solid state by means of UV-vis spectroscopy, FT-IR, ¹H and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and stability of alpinetin were obviously increased in the inclusion complex with HPβCD. This satisfactory water solubility and high stability of the alpinetin/HPβCD complex will be potentially useful for its application as herbal medicine or healthcare products.
Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, PR China.
Shui-Xian
SX
Ma
Wen
W
Chen
Xiao-Dong
XD
Yang
Na
N
Zhang
Shao-Jie
SJ
Wang
Lin
L
Liu
Li-Juan
LJ
Yang
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D044950:Flavanones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D033362:Powder Diffraction; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
D044950:Flavanones; C436748:alpinetin; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin