Stem cell-based therapies: promises, obstacles, discordance, and the agora.
Stem cell research has entered the public consciousness through the media. Proponents and opponents of all such research, or of human embryonic stem cell research specifically, engage in heated exchanges in the modern public forum where stakeholders negotiate, the agora. One common claim that emerges from the fray is that a particular type of stem cell research should be pursued as the most promising path toward the reduction of suffering and untimely death for all of humanity. Upon evaluation, experimental data regarding the potential role of stem cells in regenerative therapies for three conditions-spinal cord injury, type 1 diabetes, and cardiovascular disease-tell distinct, complex, and inconclusive stories. Further analyses in this article incorporate realistic considerations of a broad range of relevant factors: limited funding for biomedical research, media motives, the discordance hypothesis of evolutionary medicine, the relationship between religion and science, medical care in developing nations, and culture wars over abortion. Holistic investigation inspired by the current agora conversation supports the need to drastically change interactions regarding stem cell research so that its potential to benefit humanity may be more fully realized.
Center for Nano Science and Technology, University of Notre Dame, Notre Dame, IN 46556, USA. keggleso@nd.edu
Kathleen K
KK
Eggleson
D002318:Cardiovascular Diseases / Q000628:therapy*; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D053595:Embryonic Stem Cells / Q000502:physiology / Q000637:transplantation*; D006293:Health Promotion; D006801:Humans; D050417:Insulin-Secreting Cells / Q000502:physiology / Q000637:transplantation; D011634:Public Health / Q000191:economics; D044968:Regenerative Medicine / Q000191:economics / Q000379:methods; D013119:Spinal Cord Injuries / Q000628:therapy*; D058630:Spinal Cord Regeneration; D057905:Stem Cell Research / Q000191:economics; D033581:Stem Cell Transplantation / Q000191:economics / Q000379:methods*