The role of micronutrients in the diet of HIV-1-infected individuals.
Vitamins, zinc and selenium are important micronutrients that play crucial functions at the cellular and molecular level. Immune response of several different cell types can be modulated by these micronutrients. Deficiency in micronutrients has been extensively reported in HIV-1-infected individuals and further correlated with CD4+ T-cell count, HIV-1 plasma viral load, disease progression and mortality. Supplementation by micronutrients has had controversial effects. Thorough future investigations and trials are certainly needed to strategically plan evidence-based interventions. Here, we review the available data on use of micronutrients during the course of HIV-1 infection.
Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Catania, Italy. gnunnari@hotmail.com
Giuseppe
G
Nunnari
Christian
C
Coco
Marilia Rita
MR
Pinzone
Piero
P
Pavone
Massimiliano
M
Berretta
Michelino
M
Di Rosa
Matthias
M
Schnell
Giorgio
G
Calabrese
Bruno
B
Cacopardo
D004032:Diet; D005260:Female; D015658:HIV Infections / Q000178:diet therapy*; D015497:HIV-1; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage*; D018384:Oxidative Stress; D011247:Pregnancy; D012643:Selenium / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage
D018977:Micronutrients; D012643:Selenium; D015032:Zinc