Globus pharyngeus: a review of its etiology, diagnosis and treatment.
Globus is a persistent or intermittent non-painful sensation of a lump or foreign body in the throat. It is a commonly encountered clinical condition that is usually long-lasting, difficult to treat, and has a tendency to recur. Furthermore, due to the uncertain etiology of globus, it remains difficult to establish standard investigation and treatment strategies for affected patients. As a first step for managing globus, careful history taking and nasolaryngoscopy are essential. Given the benign nature of the condition and the recent notion that gastroesophageal reflux disease is a major cause of globus, empirical therapy with a high dose of proton pump inhibitors is reasonable for patients with typical globus. If patients are nonresponsive to this therapy, definitive assessments such as endoscopy, multichannel intraluminal impedance/pH monitoring, and manometry should be considered. Speech and language therapy, anti-depressants, and cognitive-behavioral therapy can be helpful in patients whose symptoms persist despite negative investigations.
Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 602-739, South Korea.
Bong Eun
BE
Lee
Gwang Ha
GH
Kim
D000465:Algorithms; D015928:Cognitive Behavioral Therapy; D006801:Humans; D010608:Pharyngeal Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012677:Sensation; D013070:Speech Therapy
D054328:Proton Pump Inhibitors