Mechanical properties of porcine femoral cortical bone measured by nanoindentation.
This study uses a nanoindentation technique to examine variations in the local mechanical properties of porcine femoral cortical bone under hydrated conditions. Bone specimens from three age groups (6, 12 and 42 months), representing developing bone, ranging from young to mature animals, were tested on the longitudinal and transverse cross-sectional surfaces. Elastic modulus and hardness of individual lamellae within bone's microstructure: laminar bone, interstitial bone, and osteons, were measured. Both the elastic modulus and hardness increased with age. However, the magnitudes of these increases were different for each microstructural component. The longitudinal moduli were higher than the transverse moduli. Dehydrated samples were also tested to allow a comparison with hydrated samples and these resulted in higher moduli and hardness than the hydrated samples. Again, the degree of variation was different for each microstructural component. These results indicate that the developmental changes in bone have different rates of mechanical change within each microstructural component.
Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Liang
L
Feng
Michael
M
Chittenden
Jeffrey
J
Schirer
Michelle
M
Dickinson
Iwona
I
Jasiuk
D000375:Aging / Q000502:physiology*; D000818:Animals; D001846:Bone Development / Q000502:physiology*; D055119:Elastic Modulus / Q000502:physiology; D005269:Femur / Q000503:physiopathology / Q000648:ultrastructure; D006245:Hardness Tests; D013312:Stress, Physiological / Q000502:physiology*; D013552:Swine