Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing.
Eraserhead: Stem cells seem to erase epigenetic information by decarboxylation of the newly discovered epigenetic base 5-carboxycytosine (caC; see picture). This reaction is likely to involve a nucleophilic attack of the C5-C6 double bond.
Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians Universität München, Butenandtstrasse 5-13, 81377 München, Germany.
Stefan
S
Schiesser
Benjamin
B
Hackner
Toni
T
Pfaffeneder
Markus
M
Müller
Christian
C
Hagemeier
Matthias
M
Truss
Thomas
T
Carell
D000818:Animals; D001483:Base Sequence; D003596:Cytosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D003653:Decarboxylation; D053595:Embryonic Stem Cells / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D009587:Nitrogen Isotopes / Q000737:chemistry; D010084:Oxidation-Reduction
C560974:5-carboxylcytosine; D009587:Nitrogen Isotopes; D003596:Cytosine; D004247:DNA