Quantification of four arsenic species in fruit juices by ion-chromatography-inductively coupled plasma-mass spectrometry.
A method using ion chromatography-inductively coupled plasma-mass spectrometry (IC-ICP-MS) for the quantification of arsenic species in fruit juices has been developed and validated. The method is capable of quantifying four anionic arsenic species - arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) - in the presence of unretained species such as arsenobetaine (AsB). Method validation was based on repeatability, analysis of reference materials, recovery of fortified samples, and determination of detection and quantification limits. The method was tested for use with apple, pear, cranberry, grape (red, white and purple) juices, as well as several juice blends. Limits of detection were 0.35, 0.41, 0.45 and 0.70 µg kg⁻¹ for As(III), DMA, MMA and As(V), respectively. Chromatographic recovery was good for most samples (90-107% compared to total arsenic), though recovery for some grape juice samples was lower (67-78%).
Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, USA. sean.conklin@fda.hhs.gov
Sean D
SD
Conklin
Peter E
PE
Chen
D001152:Arsenicals / Q000032:analysis*; D001628:Beverages / Q000032:analysis*; D002138:Calibration; D002273:Carcinogens / Q000032:analysis*; D002852:Chromatography, Ion Exchange; D005506:Food Contamination; D005513:Food Inspection / Q000379:methods*; D005638:Fruit / Q000737:chemistry*; D057230:Limit of Detection; D013058:Mass Spectrometry; D015203:Reproducibility of Results; D014481:United States; D014486:United States Food and Drug Administration
D001152:Arsenicals; D002273:Carcinogens