The effect of bone marrow-derived cells on diastolic function and exercise capacity in patients after acute myocardial infarction.
BACKGROUND
The early- to mid-term impact of bone-marrow-derived stem cells (BMC) on diastolic function and exercise capacity after acute myocardial infarction (AMI) remains controversial. We performed a systematic analysis to assess whether BMC transfer is related to an early improvement in diastolic function and exercise capacity after AMI.


METHODS
Randomized controlled trials (RCTs) of BMC therapy after AMI were extracted from MEDLINE, EMBASE and CENTRAL and analyzed for a change in tissue Doppler annular early (Ea) and late diastolic (Aa) velocities, mitral inflow E velocity to tissue Doppler Ea (E/Ea) ratio, exercise time and exercise capacity.


RESULTS
A total of 365 patients were included from 6 trials. A greater improvement was observed in the E/Ea ratio after 1 year in the BMC group compared to the control group. Additionally, the BMC-treated patients had a larger improvement in exercise time, ventilation/CO₂ production (VE/VCO₂ slope) and respiratory exchange ratio (RER) after 1 year.


CONCLUSIONS
The results indicate that intracoronary BMC treatment in AMI patients leads to a mid-term improvement in diastolic function and exercise capacity.
Department of Cardiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Meng
M
Jiang
Jialiang
J
Mao
Ben
B
He
D000368:Aged; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003971:Diastole / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D017594:Publication Bias