Complexation using direct current: novel batch method for drug-resinate preparation.
Pharmaceutically, resinates are used for the development of drug delivery technologies including targeted drug delivery, taste masking, dissolution improvement of drug and its stabilization. Laboratory methods used for the preparation of resinates involve the reaction between drug and ion exchange polymer by column or batch process. Present study investigated the effect of electric current (0.1-10 mA) on the complexation of drug, verapamil hydrochloride (model drug) with resin. Direct current (DC) (1 mA) applied during activation or complexation alone or both demonstrated significant increase in verapamil hydrochloride-resin complexation as compare to conventional methods. Moreover, further increase in intensity of current above 1 mA failed to increase the drug binding. This study suggests the use of electric current as a novel batch method for the preparation of drug-resinates.
Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India.
Amol Baburao
AB
Jumde
Milind Janrao
MJ
Umekar
Nandkishor Ramdas
NR
Kotagale
D016503:Drug Delivery Systems; D004563:Electrochemistry; D007475:Ion Exchange Resins / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014700:Verapamil / Q000737:chemistry*
D007475:Ion Exchange Resins; D014700:Verapamil