Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study.
We conducted a multicenter prospective randomized study to compare a fixed-scheduled induction therapy with a response-oriented individualized induction therapy for elderly patients with acute myeloid leukemia (AML). Newly diagnosed AML patients, aged between 65 and 80, were randomly assigned to receive fixed or individualized induction. Both groups received daunorubicin (DNR) 40 mg/m(2) for 3 days and behenoyl cytarabine (BHAC) 200 mg/m(2) for 8 days. In the individualized group, bone marrow biopsy was done on days 8 and 10, and according to the cellularity and blast ratio, the patients received additional DNR and BHAC for two to four more days. All patients achieving complete remission (CR) were randomized a second time to determine whether they would receive ubenimex. CR was obtained in 60.1 % of the fixed group and 63.6 % of the individualized group. Predicted 4-year relapse-free survival (RFS) was 9 % for the fixed group and 18 % for the individualized group. There were no statistically significant differences in CR and RFS between the fixed and individualized groups. In the ubenimex group, prolonged RFS was observed. Notably, gender was a prognostic factor in this study, as 102 female patients had a significantly higher CR rate (72.5 vs. 54.3 %, p = 0.0048) and better OS (24 vs. 14 % at 4 years, p = 0.018), compared with 140 male patients.
Division of Hematology and Oncology, Nagoya City West Medical Center, 1-1 Hirate-cho 1-chome, Kita-ku, Nagoya, Japan. a.wakita.94@west-med.jp
Atsushi
A
Wakita
Shigeki
S
Ohtake
Satoru
S
Takada
Fumiharu
F
Yagasaki
Hirokazu
H
Komatsu
Yasushi
Y
Miyazaki
Kohmei
K
Kubo
Yukihiko
Y
Kimura
Akihiro
A
Takeshita
Yoko
Y
Adachi
Hitoshi
H
Kiyoi
Takuhiro
T
Yamaguchi
Minoru
M
Yoshida
Kazunori
K
Ohnishi
Shuichi
S
Miyawaki
Tomoki
T
Naoe
Ryuzo
R
Ueda
Ryuzo
R
Ohno
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D060830:Consolidation Chemotherapy; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007930:Leucine / Q000008:administration & dosage / Q000031:analogs & derivatives; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D016019:Survival Analysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D007930:Leucine; C012211:ubenimex