Ternifolide A, a new diterpenoid possessing a rare macrolide motif from Isodon ternifolius.
Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Juan
J
Zou
Xue
X
Du
Guo
G
Pang
Yi-Ming
YM
Shi
Wei-Guang
WG
Wang
Rui
R
Zhan
Ling-Mei
LM
Kong
Xiao-Nian
XN
Li
Yan
Y
Li
Jian-Xin
JX
Pu
Han-Dong
HD
Sun
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D004224:Diterpenes; D018942:Macrolides; D013729:Terpenes; C576150:ternifolide A