Copper-mediated and copper-catalyzed cross-coupling of indoles and 1,3-azoles: double C-H activation.
A new bronze age: the described copper-mediated cross-coupling with double C-H activation can provide a convergent access to indole-containing biheteroaryls that are of high interest in pharmaceutical and medicinal chemistry. In this strategy an easily attachable and detachable 2-pyrimidyl directing group is used. Moreover, a variant that is catalytic in copper is achieved by using atmospheric oxygen as an ideal co-oxidant.
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Japan.
Mayuko
M
Nishino
Koji
K
Hirano
Tetsuya
T
Satoh
Masahiro
M
Miura
D001393:Azoles / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000494:pharmacology*; D058451:Oxidative Coupling; D010100:Oxygen / Q000737:chemistry*
D001393:Azoles; D001583:Benzoxazoles; D007211:Indoles; D016877:Oxidants; D002244:Carbon; D003300:Copper; D010100:Oxygen