Roles and underlying mechanisms of ESAT-6 in the context of Mycobacterium tuberculosis-host interaction from a systems biology perspective.
The 6kDa early secreted antigenic target (ESAT-6), an important and intensively studied virulence factor of Mycobacterium tuberculosis, acts alone or in combination with CFP-10 to influence the outcome of the host-pathogen interaction. Secreted ESAT-6 can disturb the activation of macrophages, induce apoptosis and subvert host immunity. ESAT-6 mediated autophagosome formation and TLR signaling deviation lead to abnormal activation of NF-κB and subsequent erroneous expression of NF-κB-dependent genes. The C-terminal amino acid residues 90-95 in ESAT-6 are essential for the interaction with host. In-depth appreciation of the multiple roles of ESAT-6 upon host can inform improvements for novel vaccines and diagnostic tools for tuberculosis.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
Xiaowen
X
Yu
Jianping
J
Xie
D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D049490:Systems Biology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C093276:ESAT-6 protein, Mycobacterium tuberculosis