[Intensity of free radical oxidation and superoxide dismutase activity in patients with drug hepatitis in combination therapy with melaxen or epifamin].
Intensity of free radical oxidation processes and superoxide dismutase activity at patients with drug-induced hepatitis at the combined therapy with melaxen or epifamin. Free radical homoeostasis state at patients with drug-induced hepatitis being on standard treatment, including hepatoprotectors, and the combined therapy with melaxen or epifamin has been investigated. Biochemiluminescence parameters in blood serum point out to intensification of free radical processes and inhibition of antioxidant defense of organism, at this time superoxide dismutase activity in blood serum increased. After leading of standard therapy a decline of oxidative stress expression was observed. Incorporation to base treatment of melaxen or epifamin accompanied by correction of antioxidant status of organism and provided more expressed antioxidant effect, that confirmed by changing of biochemiluminescence parameters and superoxide dismutase activity. Obviously, it is related to antiradical properties of melatonin the level of which is corrected under the action of these preparations.
S S
SS
Popov
K K
KK
Shul'gin
A N
AN
Pashkov
V I
VI
Zoloedov
G I
GI
Shvedov
D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010455:Peptides / Q000008:administration & dosage*; D017382:Reactive Oxygen Species / Q000097:blood*; D013482:Superoxide Dismutase / Q000378:metabolism*
D010455:Peptides; D017382:Reactive Oxygen Species; C551699:epifamin; D013482:Superoxide Dismutase