Xylitol concentrations in artificial saliva after application of different xylitol dental varnishes.
OBJECTIVE
The present study analyzed xylitol concentrations in artificial saliva over time after application of varnishes containing 10% and 20% xylitol.


METHODS
Fifteen bovine enamel specimens (8x4 mm) were randomly allocated to 3 groups (n=5/group), according to the type of varnish used: 10% xylitol, 20% xylitol and no xylitol (control). After varnish application (4 mg), specimens were immersed in vials containing 500 µL of artificial saliva. Saliva samples were collected in different times (1, 8, 12, 16, 24, 48 and 72 h) and xylitol concentrations were analyzed. Data were assessed by two-way repeated-measures ANOVA (p<0.05).


RESULTS
Colorimetric analysis was not able to detect xylitol in saliva samples of the control group. Salivary xylitol concentrations were significantly higher up to 8 h after application of the 20% xylitol varnish. Thereafter, the 10% xylitol varnish released larger amounts of that polyol in artificial saliva.


CONCLUSIONS
Despite the results in short-term, sustained xylitol releases could be obtained when the 10% xylitol varnish was used. These varnishes seem to be viable alternatives to increase salivary xylitol levels, and therefore, should be clinically tested to confirm their effectiveness.
School of Dentistry, University of Cuiabá, Cuiabá, MT, Brazil.
Agnes de Fátima Faustino
Ade F
Pereira
Thiago Cruvinel da
TC
Silva
Thelma Lopes da
TL
Silva
Magali de Lourdes
Mde L
Caldana
José Roberto Magalhães
JR
Bastos
Marília Afonso Rabelo
MA
Buzalaf
D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D003731:Dental Caries / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects; D011897:Random Allocation; D012464:Saliva, Artificial / Q000032:analysis*; D013549:Sweetening Agents / Q000032:analysis*; D013997:Time Factors; D014993:Xylitol / Q000032:analysis*
D012464:Saliva, Artificial; D013549:Sweetening Agents; D014993:Xylitol