Feasibility study of paclitaxel plus carboplatin in patients with endometrial cancer: a Japan Kanto Tumor Board study (JKTB trial).
OBJECTIVE
The optimal chemotherapy regimen for patients with endometrial cancer has not been established. We assessed the feasibility of paclitaxel plus carboplatin (TC) for postoperative chemotherapy in patients with endometrial cancer.


METHODS
Patients with newly diagnosed endometrial cancer received TC (paclitaxel 180 mg/m(2) , carboplatin AUC6 mg/mL/min) every three weeks. Treatment was continued until disease progression or completion of six cycles. Toxicities were evaluated every cycle according to NCI-CTCAE version 3.0.


RESULTS
Sixty patients were registered from December 2005 through November 2006. Forty-four of 60 (73.3%) cases completed all of the planned six cycles. Grades 3 and 4 hematologic toxicities were observed as follows: leukopenia (61.7%), neutropenia (95.0%), anemia (21.7%), and thrombocytopenia (5.0%). There were six patients who dropped out from the protocol by neutropenia. Grade 3 non-hematologic toxicities were observed as follows: nausea (3.3%), vomiting (1.7%), neuropathy (5.0%), myalgia (6.7%) and constipation (1.7%). No grade 4 non-hematologic toxicity was observed.


CONCLUSIONS
This TC regimen is feasible for endometrial cancer patients.
Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Minato-ku Azabu-juban Manami Women's Clinic, Minato-ku, Tokyo, Japan. kyosuke@jikei.ac.jp
Kyosuke
K
Yamada
Hiroshi
H
Tanabe
Manami
M
Imai
Toshiko
T
Jobo
Kazuya
K
Kudo
Hiroyuki
H
Fujiwara
Chie
C
Nagata
Kenichi
K
Furuya
Mitsuaki
M
Suzuki
Kazunori
K
Ochiai
Tadao
T
Tanaka
Makoto
M
Yasuda
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000188:drug therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D016190:Carboplatin; D017239:Paclitaxel