An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection.
We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C-O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.
Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, China.
Shaobo
S
Long
Lin
L
Chen
Yumi
Y
Xiang
Minggui
M
Song
Yuguo
Y
Zheng
Qing
Q
Zhu
D001665:Binding Sites; D003374:Coumarins / Q000737:chemistry* / Q000378:metabolism; D057075:Enzyme Assays / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000032:analysis / Q000378:metabolism*; D010084:Oxidation-Reduction; D011485:Protein Binding; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods
D003374:Coumarins; D005456:Fluorescent Dyes; D008995:Monoamine Oxidase