Dna2 offers support for stalled forks.
The ATR and ATM checkpoint kinases preserve the integrity of replicating chromosomes by preventing the reversal of stalled and terminal replication forks. Hu et al. now show that the ATR pathway targets the Dna2 nuclease to process stalled forks and counteract fork reversal.
Fondazione Istituto FIRC di Oncologia Molecolare, IFOM-IEO Campus, Milan, Italy.
Mong Sing
MS
Lai
Marco
M
Foiani