Spatiotemporal analysis of indigenous and imported dengue fever cases in Guangdong province, China.
BACKGROUND
Dengue fever has been a major public health concern in China since it re-emerged in Guangdong province in 1978. This study aimed to explore spatiotemporal characteristics of dengue fever cases for both indigenous and imported cases during recent years in Guangdong province, so as to identify high-risk areas of the province and thereby help plan resource allocation for dengue interventions.


METHODS
Notifiable cases of dengue fever were collected from all 123 counties of Guangdong province from 2005 to 2010. Descriptive temporal and spatial analysis were conducted, including plotting of seasonal distribution of cases, and creating choropleth maps of cumulative incidence by county. The space-time scan statistic was used to determine space-time clusters of dengue fever cases at the county level, and a geographical information system was used to visualize the location of the clusters. Analysis were stratified by imported and indigenous origin.


RESULTS
1658 dengue fever cases were recorded in Guangdong province during the study period, including 94 imported cases and 1564 indigenous cases. Both imported and indigenous cases occurred more frequently in autumn. The areas affected by the indigenous and imported cases presented a geographically expanding trend over the study period. The results showed that the most likely cluster of imported cases (relative risk = 7.52, p < 0.001) and indigenous cases (relative risk = 153.56, p < 0.001) occurred in the Pearl River Delta Area; while a secondary cluster of indigenous cases occurred in one district of the Chao Shan Area (relative risk = 471.25, p < 0.001).


CONCLUSIONS
This study demonstrated that the geographic range of imported and indigenous dengue fever cases has expanded over recent years, and cases were significantly clustered in two heavily urbanised areas of Guangdong province. This provides the foundation for further investigation of risk factors and interventions in these high-risk areas.
Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China.
Zhongjie
Z
Li
Wenwu
W
Yin
Archie
A
Clements
Gail
G
Williams
Shengjie
S
Lai
Hang
H
Zhou
Dan
D
Zhao
Yansha
Y
Guo
Yonghui
Y
Zhang
Jinfeng
J
Wang
Wenbiao
W
Hu
Weizhong
W
Yang
D002681:China / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000635:transmission; D040362:Geographic Information Systems; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D012621:Seasons; D013029:Space-Time Clustering; D014195:Travel