Role of chemokines polymorphisms in diseases.
The interest into chemokine polymorphisms came with the discovery of allelic variants of HIV co-receptors (CCR5 and CXCR4 mainly) that confers protection against virus entry into usual permissive cells. Since then, chemokines genetic background has been deeply studied in order to find associations between allelic variants and inflammation-related diseases as well as infectious diseases. In addition to HIV infection, chemokines genetic variations have been involved in other infectious diseases as HCV, Malaria and West Nile Virus, and also in a variety of non-infectious diseases such as cancer, auto-immune and cardiovascular diseases. This review aims to present genetic variations in chemokines encoding genes and discuss their role, sometimes controversial, in a variety of diseases.
Laboratory of Immunity and Infection, INSERM UMRS-945, UPMC Univ Paris 06, Paris, France.
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Combadière
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D002318:Cardiovascular Diseases / Q000235:genetics / Q000276:immunology; D002465:Cell Movement; D018925:Chemokines / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007239:Infections / Q000235:genetics / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics* / Q000276:immunology
D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine