New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714.
In an experimental permanent stroke model, we report here the contribution of ONO-1714 to brain damage prevention. Daily drug administration, twenty-one days prior to and two days after an experimental infarct, was performed by using mini-osmotic pumps (ALZET). Infarct volumes were assessed by image analysis of sequential coronal brain 1 mm(3) sections stained following the 2,3,5-triphenyltetrazolium chloride histological staining technique. Results of this study provide evidence of a significant reduction of the brain lesion size, suggesting ONO-1714 as a potential neuroprotective agent in stroke patients. ONO-1714 was prepared in our laboratory following a procedure which resulted in the supply of the desired compound in an easy and excellent yield.
Neurovascular Research Group, Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal (CSIC), Av. Doctor Arce 37, 28002 Madrid, Spain.
Andrea
A
Pozo-Rodrigálvarez
Ana
A
Gradillas
Julia
J
Serrano
Ana Patricia
AP
Fernández
Ricardo
R
Martínez-Murillo
Javier
J
Pérez-Castells
D000578:Amidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D060326:Chemistry Techniques, Synthetic; D006574:Heterocyclic Compounds, 2-Ring / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology; D007260:Infusion Pumps; D008297:Male; D051379:Mice; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D020521:Stroke / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*
C407360:7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane; D000578:Amidines; D006574:Heterocyclic Compounds, 2-Ring; D018696:Neuroprotective Agents