Post-translational modulation of pluripotency.
The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.
National Laboratory of Biomacromolecules, Institute of Biophysics,  Chinese Academy of Sciences, Beijing 100101,  China.
Ning
N
Cai
Mo
M
Li
Jing
J
Qu
Guang-Hui
GH
Liu
Juan Carlos
JC
Izpisua Belmonte
D006801:Humans; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D025841:Small Ubiquitin-Related Modifier Proteins; D014157:Transcription Factors