Nuclear translation or nuclear peptidyl transferase?
It is widely accepted that protein synthesis occurs in the cytoplasms of eukaryotic cells, but some investigators believe that it also occurs in the nucleus. In spite of experiments performed in several labs over many years, the issue of nuclear translation remains unresolved. Advocates assert that it would serve as an economical and convenient way to explain how cells monitor the quality of newly made mRNAs or ribosomes. Skeptics argue that regardless of its esthetic appeal, compelling evidence for nuclear translation has been absent. The key question--also central to the debate more than 30 years ago--is whether alleged nuclear translation can be proven to represent "genuine polypeptide synthesis that is a function of the nuclear compartment".
Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. dahlberg@wisc.edu
James
J
Dahlberg
Elsebet
E
Lund
D002467:Cell Nucleus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011691:Puromycin / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011691:Puromycin; D010458:Peptidyl Transferases