Emerging role of autophagy in kidney function, diseases and aging.
Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.
Renal Division, University Hospital Freiburg; Freiburg, Germany. tobias.huber@uniklinik-freiburg.de
Tobias B
TB
Huber
Charles L
CL
Edelstein
Björn
B
Hartleben
Ken
K
Inoki
Man
M
Jiang
Daisuke
D
Koya
Shinji
S
Kume
Wilfred
W
Lieberthal
Nicolas
N
Pallet
Alejandro
A
Quiroga
Kameswaran
K
Ravichandran
Katalin
K
Susztak
Sei
S
Yoshida
Zheng
Z
Dong
D000375:Aging / Q000473:pathology* / Q000502:physiology; D001343:Autophagy; D006262:Health; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000502:physiology* / Q000503:physiopathology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000473:pathology* / Q000503:physiopathology*; D008954:Models, Biological