Primary effusion lymphoma with central nervous system involvement in an HIV-negative homosexual male.
Primary effusion lymphoma (PEL) is a rare form of non-Hodgkin lymphoma that presents with body cavity effusions. It occurs chiefly in immunodeficient HIV-positive patients. The tumor cells generally express gene sequences of human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV). Tumor cells of HIV-negative patients usually express HHV-8 gene sequences, but rarely those of EBV. We report a novel case of PEL in an HIV-negative homosexual male whose tumor cells expressed both HHV-8 and EBV gene sequences and who developed evidence of central nervous system involvement.
New York University Langone Medical Center, New York, NY 10016, USA.
Oluyomi E
OE
Kabiawu-Ajise
Jonathan
J
Harris
Naima
N
Ismaili
Edward
E
Amorosi
Sherif
S
Ibrahim
D000368:Aged; D002493:Central Nervous System Diseases / Q000473:pathology*; D018023:HIV Seronegativity; D018451:Homosexuality, Male; D006801:Humans; D016130:Immunophenotyping; D054685:Lymphoma, Primary Effusion / Q000473:pathology*; D008297:Male