Genetic fine structure of a Salmonella enterica serovar Typhi strain associated with the 2005 outbreak of typhoid fever in Kelantan, Malaysia.
Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of Salmonella Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent Salmonella Typhi strain BL196/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere.
Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Ramani
R
Baddam
Narender
N
Kumar
Kwai-Lin
KL
Thong
Soo-Tein
ST
Ngoi
Cindy Shuan Ju
CS
Teh
Kien-Pong
KP
Yap
Lay-Ching
LC
Chai
Tiruvayipati Suma
TS
Avasthi
Niyaz
N
Ahmed
D004196:Disease Outbreaks; D016680:Genome, Bacterial; D008296:Malaysia / Q000453:epidemiology; D008969:Molecular Sequence Data; D012485:Salmonella typhi / Q000235:genetics / Q000472:pathogenicity; D017422:Sequence Analysis, DNA; D014435:Typhoid Fever / Q000453:epidemiology / Q000382:microbiology; D014774:Virulence