Palladium-catalyzed sequential formation of C-C bonds: efficient assembly of 2-substituted and 2,3-disubstituted quinolines.
A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Xiaochen
X
Ji
Huawen
H
Huang
Yibiao
Y
Li
Huoji
H
Chen
Huanfeng
H
Jiang