A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect.
BACKGROUND
Peden et al. have revealed a significant association between four new risk loci and coronary heart disease (CHD) in Europeans and South Asians. The goal of this study is to evaluate the contribution of these genetic loci to CHD risk in Han Chinese.


METHODS
We recruited 161 CHD patients and 112 controls proved by angiography originated from Ningbo in the Eastern China, and performed a case-control association study of the four significant SNPs.


RESULTS
Among the four tested SNPs, we found a significant association of rs974819 in PDGFD gene with CHD (allele p=0.04; OR=1.45, 95% CI=1.02 - 2.08) and the allele A/G of rs974819 shows significant difference in females (allele p=0.04; OR=1.83, 95% CI=1.01 - 3.31). A further meta-analysis showed that rs974819 of PDGFD gene was significantly associated with an increasing risk of CHD (OR=1.08, 95% CI=1.05 - 1.11) in both Europeans and South Asians including Han Chinese.


CONCLUSIONS
Our findings suggests that rs974819 of PDGFD is also a CHD risk factor in Han Chinese. In addition, it presents a sex-dependent genetic effect.
Ningbo Medical Center, Lihuili hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Jianqing
J
Zhou
Yi
Y
Huang
R Stephanie
RS
Huang
Feiming
F
Wang
Limin
L
Xu
Yanping
Y
Le
Xi
X
Yang
Weifeng
W
Xu
Xiaoyan
X
Huang
Jiangfang
J
Lian
Shiwei
S
Duan
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008222:Lymphokines / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D044465:White People / Q000235:genetics
D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor