Subtype-specific parafollicular localization of the neuropeptide manserin in the rat thyroid gland.
The thyroid gland is an endocrine organ which is involved in metabolism, neuroexcitability, body growth and development. The thyroid gland is also involved in the regulation of calcium metabolism, which is not yet fully understood. In this study, we investigated the localization of the granin-derived neuropeptide, manserin, in the adult rat thyroid gland. Manserin immunoreactivity was detected in thyroid follicular epithelial cells. Intense manserin signals were also detected in some, but not all, parafollicular cells, indicating that parafollicular manserin may be subtype-specific. These results indicate that thyroid manserin may play pivotal roles in parafollicular cells and follicular epithelial cells such as in calcium metabolism and/or thyroid hormone secretion.
Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, Mie, Japan. tohkawara@doc.medic.mie-u.ac.jp
Takeshi
T
Ohkawara
Akiko
A
Oyabu
Michiru
M
Ida-Eto
Yasura
Y
Tashiro
Naoko
N
Narita
Masaaki
M
Narita
D000818:Animals; D002864:Chromogranins / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism
D002864:Chromogranins; D009479:Neuropeptides; D010446:Peptide Fragments; C492467:manserin, rat; D013972:Thyrotropin