The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.
The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use.
The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Edinburgh, Midlothian EH25 9RG, UK. katherine.staines@roslin.ed.ac.uk
Katherine A
KA
Staines
Vicky E
VE
MacRae
Colin
C
Farquharson
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D058574:Integrin-Binding Sialoprotein / Q000502:physiology; D016023:Integrins / Q000502:physiology; D053495:Osteopontin / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D012795:Sialoglycoproteins / Q000502:physiology; D000099311:Dentin Sialophosphoprotein
D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D058574:Integrin-Binding Sialoprotein; D016023:Integrins; D053495:Osteopontin; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D000099311:Dentin Sialophosphoprotein; C513309:DMP1 protein, human; C486579:MEPE protein, human