Diversity of mitral valve abnormalities in obstructive hypertrophic cardiomyopathy.
Hypertrophic cardiomyopathy (HCM) is a complex and common genetic disease. The left ventricular outflow tract obstruction is an important determinant of symptoms and outcomes. Its pathophysiology is determined by the complex interaction of the mitral valve, papillary muscles, chordae tendinea, and interventricular septum. The knowledge and importance of the mitral valve apparatus in the physiology of the HCM are expanding with the new imaging modalities, in particular, cardiac magnetic resonance. Several abnormalities of the mitral apparatus have been described in patients with HCM including abnormal papillary muscles, leaflets' lengths, and mitral regurgitation. Ignoring these variables can lead to unnecessary or incomplete surgical treatments and worse outcomes. This review discusses the role of the mitral apparatus in HCM with a focus on a multimodality imaging approach and the clinical importance of each abnormality.
Cleveland Clinic Foundation, Department of Cardiovascular Medicine, Section of Cardiac Imaging, Cleveland, OH 44195, USA.
João L
JL
Cavalcante
Joaquim S
JS
Barboza
Harry M
HM
Lever
D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods; D008943:Mitral Valve / Q000002:abnormalities*; D010210:Papillary Muscles / Q000002:abnormalities*