[Immune-mediated encephalomyelitis following varicella-zoster virus infection after allogeneic stem cell transplantation].
A 40-year-old Japanese man with acute myeloid leukemia received allogeneic bone marrow transplantation. On day 101, varicella-zoster virus (VZV) infection occurred, but was improved by administration of acyclovir and immunoglobulin. On day 119, he complained of numbness and double vision, and he was admitted due to exacerbation of the symptoms. The findings of cerebrospinal fluid and magnetic resonance image examination were consistent with the diagnosis of immune-mediated encephalomyelitis (IMEM). Intravenous immunoglobulin therapy was effective and his neurological findings dramatically improved without recurrence. IMEM is a rare non-infectious inflammatory demyelinating disease that can occur after transplantation. We herein describe a case report with a review of the associated literature.
Department of Hematology, Kanagawa Cancer Center.
Takayoshi
T
Tachibana
Hirotaka
H
Takasaki
Masatsugu
M
Tanaka
Ayumi
A
Numata
Etsuko
E
Yamazaki
Fuminori
F
Segawa
Shin
S
Fujisawa
Atsuo
A
Maruta
Yoshiaki
Y
Ishigatsubo
Heiwa
H
Kanamori
D000212:Acyclovir / Q000008:administration & dosage; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D004679:Encephalomyelitis / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006562:Herpes Zoster / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D000212:Acyclovir