Mucin production and mucous cell metaplasia in otitis media.
Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM. In addition, infectious agents, mucin production triggers, and relevant signaling pathways will be discussed.
Department of Otolaryngology Head and Neck Surgery, University of Minnesota, 2001 6th Street SE, Minneapolis, MN 55455, USA.
Jizhen
J
Lin
Per
P
Caye-Thomasen
Tetsuya
T
Tono
Quan-An
QA
Zhang
Yoshihisa
Y
Nakamura
Ling
L
Feng
Jianmin
J
Huang
Shengnan
S
Ye
Xiaohua
X
Hu
Joseph E
JE
Kerschner