Multifocal intraepithelial neoplasia and the psychological consequence of vulvectomy.
A 41-year-old female with significant psychiatric history presented with persistent vulvar lesions that were refractory to common clinic and home based wart therapies. Vulvoscopy directed biopsies confirmed invasive vulvar squamous cell carcinoma and further investigation revealed cervical and anal intraepithelial neoplasia in a patient who remained HIV negative with no other cause of immunosuppression detected other than smoking. Vulvectomy following cancer diagnosis lead to a relapse of her psychiatric illness and excessive alcohol intake. Her psychiatric illness in turn affected her further management and follow-up. This case highlights the need for the case based, medical, surgical, psychological and social considerations when managing persistent anogenital warts and anogenital neoplasia as well as the psychological impact of vulvectomy.
Sexual Health, Homerton University Hospital, London, UK. shahidshah@doctors.net.uk
Shahid Hussain
SH
Shah
Sashidharan
S
Parameswaran
Nicola
N
Hickey
Sarah
S
Zetler
Mayura
M
Nathan
D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000379:methods; D006801:Humans; D001523:Mental Disorders / Q000209:etiology*; D014844:Vulva / Q000601:surgery*; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery