Preeclampsia, placenta, oxidative stress, and PMCA.
OBJECTIVE
The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration.


METHODS
Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included.


RESULTS
Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described.


CONCLUSIONS
Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.
Laboratorio de Bioenergética Celular, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Cilia
C
Abad
Teresa
T
Proverbio
Sandy
S
Piñero
Desirée
D
Botana
Delia I
DI
Chiarello
Reinaldo
R
Marín
Fulgencio
F
Proverbio
D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D010920:Placenta / Q000378:metabolism*; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy
D053499:Plasma Membrane Calcium-Transporting ATPases