The influence of physical activity in the progression of experimental lung cancer in mice.
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb - C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
School of Medicine of São José do Rio Preto - FAMERP, Department of Pathology and Forensic Medicine, Brazil.
Renato Batista
RB
Paceli
Rodrigo Nunes
RN
Cal
Carlos Henrique Ferreira
CH
dos Santos
José Antonio
JA
Cordeiro
Cassiano Merussi
CM
Neiva
Kazuo Kawano
KK
Nagamine
Patrícia Maluf
PM
Cury
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D004195:Disease Models, Animal; D018450:Disease Progression; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010805:Physical Conditioning, Animal / Q000502:physiology*; D003074:Solitary Pulmonary Nodule / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D013550:Swimming; D014520:Urethane / Q000633:toxicity
D002273:Carcinogens; D014520:Urethane