Sodium alginate oligosaccharides attenuate hypertension in spontaneously hypertensive rats fed a low-salt diet.
We investigated the effects of sodium alginate oligosaccharides (alginate) on the development of spontaneous hypertension in rats. Spontaneous hypertensive rats were treated with alginate for 7 weeks. Systolic blood pressure (SBP) and cardiovascular and kidney damage were assessed. Systolic blood pressure increased in SHRs and this elevation was attenuated with alginate treatment. The heart weight tended to decline. Alginate did not change plasma cholesterol levels or urinary sodium excretions. The slightly higher urinary protein excretion in SHRs was not changed with the treatment; however, morphologic glomerular damage was significantly attenuated. Sodium alginate oligosaccharide attenuates spontaneous hypertension in SHRs, and may help prevent early-stage kidney injury.
Department of Clinical Nutrition, Kyoritsu Women's University, Chiyoda-ku, Tokyo, Japan.
Mai
M
Ueno
Yuki
Y
Tamura
Natsuko
N
Toda
Mariko
M
Yoshinaga
Shouko
S
Terakado
Kie
K
Otsuka
Atsushi
A
Numabe
Yukari
Y
Kawabata
Itsuki
I
Murota
Nobuyuki
N
Sato
Yoshio
Y
Uehara
D000464:Alginates / Q000737:chemistry / Q000627:therapeutic use*; D000821:Animal Feed; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D020723:Glucuronic Acid / Q000737:chemistry / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use*; D006603:Hexuronic Acids / Q000737:chemistry / Q000627:therapeutic use; D006973:Hypertension / Q000178:diet therapy*; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000503:physiopathology / Q000652:urine; D008297:Male; D009844:Oligosaccharides / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D012964:Sodium / Q000652:urine
D000464:Alginates; D006490:Hemostatics; D006603:Hexuronic Acids; D009844:Oligosaccharides; D020723:Glucuronic Acid; D012964:Sodium