Rhodium(III)-catalyzed cyclization-olefination of N-acetoxyl ketoimine-alkynes.
N-Acetoxyl ketoimine-alkynes undergo Rh(III)-catalyzed oxidative olefination to afford (2-acetoxymethyl)isoquinolines bearing an ortho-olefinated aryl group via a sequence that involves (1) Rh(III)-catalyzed alkyne cyclization with intramolecular 1,3-acetoxyl migration and (2) isoquinoline-directed ortho C-H olefination.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China.
Peng
P
Zhao
Fen
F
Wang
Keli
K
Han
Xingwei
X
Li
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D000480:Alkynes; D007097:Imines; D009942:Organometallic Compounds; D012238:Rhodium