Molecular epidemiological features of Mycobacterium tuberculosis in an endemic region of Henan Province, China.
Henan Province is one of the regions with the highest tuberculosis (TB) burden in China. Among isolates collected from Zhongmou County, Henan, 21.28% (10/47) of those from 2001 and 22.95% (10/61) from 2007 were resistant to at least one drug (isoniazid, rifampicin, ethambutol or streptomycin);  90.74% (98/108) of the isolates were from the Beijing family, and 108 exhibited 105 different mycobacterial interspersed repetitive units-variable number of tandem repeats patterns. This study preliminarily reveals that Henan Province is still a high prevalence region for drug-resistant TB,  and strains collected from local TB cases have diverse genotypes, of which the Beijing family type is predominant.
Henan Center for Disease Control and Prevention, Zhengzhou, China. lihui2005yan@126.com
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D019353:Endemic Diseases; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018598:Minisatellite Repeats; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D010641:Phenotype; D016133:Polymerase Chain Reaction; D015995:Prevalence; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D055815:Young Adult
D000995:Antitubercular Agents