Tumor-to-tumor metastasis: pathology and neuroimaging considerations.
The phenomenon of tumor-to-tumor metastasis has been reported in the literature for over a century. However, it remains fairly uncommon, with fewer than 100 cases being described during that time. Virtually any benign or malignant tumor can be a recipient, but meningiomas have been implicated as the most common intracranial neoplasm to harbor metastasis. The donor neoplasm is most frequently lung or breast carcinoma, while rare cases of metastasis from other primary tumors have been reported. We report here three examples of such rare metastases. This case series reports the first documented instance involving rectal adenocarcinoma. In addition, we report two cases of metastatic prostate adenocarcinoma to a meningioma; to date of which only three cases have been published. The terms "tumor-to-tumor metastasis" and "collision tumor" are addressed, as are details of the pathology. The limitations of standard radiological imaging techniques, such as standard CT and MR, which cannot reliably identify the presence of metastasis within a meningioma are compared with physiology-based neuroimaging methods, such as perfusion MR and MR spectroscopy, which may be more useful in noninvasively differentiating tumor histology.
Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA.
Patricia
P
Moody
Kevin
K
Murtagh
Sarat
S
Piduru
Steven
S
Brem
Reed
R
Murtagh
Amyn M
AM
Rojiani
D000230:Adenocarcinoma / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D059906:Neuroimaging / Q000379:methods; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D012004:Rectal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
D014408:Biomarkers, Tumor