Amino acid sensing mechanisms: an Achilles heel in cancer?
The act of increasing mass, either in non-dividing cells or in dividing cells seeking to provide new material for daughter cells, depends upon the continued presence of extracellular nutrients in order to conserve mass. For amino acid nutrients, it appears that their insufficiency for new protein synthesis is actively monitored by both prokaryotic and eukaryotic cells, eliciting appropriate cellular responses that may depend not only on bulk nutrient supply, but also on the abundance of specific amino acids.
Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Ave., Edmonton, Alberta, Canada. rflamb@ualberta.ca
Richard F
RF
Lamb
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D005658:Fungi / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D053038:Quorum Sensing; D017459:Receptors, Amino Acid / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases
D000596:Amino Acids; D046912:Multiprotein Complexes; D011506:Proteins; D017459:Receptors, Amino Acid; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases