Design, synthesis, antibacterial activity, and molecular docking studies of novel hybrid 1,3-thiazine-1,3,5-triazine derivatives as potential bacterial translation inhibitor.
Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds 8c and 8f were found active against Gram positive and Gram negative microorganisms. Molecular docking studies have been performed on eubacterial ribosomal decoding A site (Escherichia coli 16S rRNA A site) to rationalize the probable mode of action, binding affinity, and orientation of the molecules at the active site of receptor. The structures of all these newly synthesized compounds were confirmed by their elemental analyses and spectral data techniques viz. IR, ¹H NMR, ¹³C NMR, and mass.
Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture Technology and Sciences, Formerly Allahabad Agricultural Institute, Deemed to be University, 211007 Allahabad, India. udaysingh98@gmail.com
Udaya P
UP
Singh
Manish
M
Pathak
Vaibhav
V
Dubey
Hans R
HR
Bhat
Prashant
P
Gahtori
Ramendra K
RK
Singh
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000235:genetics; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D062105:Molecular Docking Simulation; D014176:Protein Biosynthesis / Q000187:drug effects; D013843:Thiazines / Q000737:chemistry* / Q000494:pharmacology*; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013843:Thiazines; D014227:Triazines