NOMID: the radiographic and MRI features and review of literature.
Neonatal onset multisystem inflammatory disease (NOMID) is a rare autoinflammatory disorder, which manifests early in infancy. We describe a case of a 10-year-old boy who has been unwell since infancy. He presented with urticarial rash, intermittent fever and hepatosplenomegaly followed by progressive arthropathy. His joint symptoms started at two years of age, which progressively involved multiple joints, resulting in bone and joint deformities. A series of joint radiographs demonstrated bizarre enlarging physeal mass with heterogenous calcification. Magnetic resonance imaging (MRI) of the involved right ankle and knee showed characteristic thickened and calcified physeal lesions, which enhanced post-gadolinium. This debilitating disease is also known to involve the central nervous system and eyes. This case report aims to highlight the conventional radiographic and magnetic resonance imaging (MRI) findings of this physeal abnormality in NOMID syndrome.
Department of Radiology, Universiti Kebangsaan Malaysia Medical Center (UKMMC), Malaysia.
Faizah Mohd
FM
Zaki
Radhika
R
Sridharan
Tan Sook
TS
Pei
Sharaf
S
Ibrahim
Tang Swee
TS
Ping
D000843:Ankle Joint / Q000000981:diagnostic imaging / Q000473:pathology; D001168:Arthritis / Q000209:etiology; D002648:Child; D056587:Cryopyrin-Associated Periodic Syndromes / Q000000981:diagnostic imaging* / Q000473:pathology*; D005076:Exanthema / Q000209:etiology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography