Dissection of inflammatory processes using chemokine biology: Lessons from clinical models.
Chemokines help facilitate the recruitment of inflammatory cells into tissues in response to infection or inflammation, and help coordinate the actions of the leukocytes that underlie an immune response. Animal models are the experimental tools of choice for the validation of chemokine biology and have provided much insight into the workings of chemokine biology. This review summarizes findings from chemokine research obtained through the application of animal models of pulmonary fibrosis, graft-versus-host disease, colitis, renal disease and allograft rejection.
Medizinische Klinik und Poliklinik IV, Schillerstrasse 42, Ludwig-Maximilians-Universität Munich, 80336 Munich, Germany. peter.nelson@med.uni-muenchen.de
Peter J
PJ
Nelson
Mauro M
MM
Teixeira
D000818:Animals; D018925:Chemokines / Q000276:immunology*; D003092:Colitis / Q000276:immunology*; D004195:Disease Models, Animal; D055808:Drug Discovery; D006084:Graft Rejection / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007674:Kidney Diseases / Q000276:immunology*; D058990:Molecular Targeted Therapy; D016377:Organ Transplantation; D011658:Pulmonary Fibrosis / Q000276:immunology*
D018925:Chemokines