Shedding new light on vasculitis: how the LAMP story unfolded.
The last couple of years have brought some major advances both in our understanding of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis pathogenesis mechanisms and in its treatment options. Recent discoveries of completely new antigens such as lysosome-associated membrane protein-2 (LAMP-2) have meant a huge step forward, and the fact that this antigen is homologous to proteins of bacterial fimbria caused a shift in the focus regarding underlying pathomechanisms of ANCA vasculitis toward bacterial infections, mainly with Klebsiella or Escherichia species, possibly playing a role in triggering the disease. So nephrology has seen real progress in understanding of glomerulonephritis disease mechanisms - not only regarding primary membranous glomerulonephritis (with the recent identification of the phospholipase A2 receptor being the underlying antigen) but also regarding secondary pauci-immune glomerulonephritis due to ANCA-positive vasculitis.
Division of Nephrology and Hypertension, III Medical Department, Coburg General Hospital, Coburg, Germany. Hansjoerg.rothe@klinikum-coburg.de
Hansjörg
H
Rothe
D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D001808:Blood Vessels / Q000276:immunology* / Q000382:microbiology; D004927:Escherichia coli Infections / Q000150:complications / Q000276:immunology; D052120:Glycogen Storage Disease Type IIb / Q000235:genetics / Q000276:immunology; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications / Q000276:immunology; D052119:Lysosomal-Associated Membrane Protein 2 / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors; D015398:Signal Transduction
D001323:Autoantibodies; D001324:Autoantigens; D052119:Lysosomal-Associated Membrane Protein 2