Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach.
A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga  Gracilaria edulis , has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577, Japan.
Yusuke
Y
Kasai
Takanori
T
Ito
Makoto
M
Sasaki
D002384:Catalysis; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D004187:Disaccharides; D018942:Macrolides; C121303:polycavernoside A; C121304:polycavernoside B