Clinical outcomes in patients with renal artery stenosis treated with stent placement with embolic protection compared with those treated with stent alone.
OBJECTIVE
To compare the clinical outcomes in patients with chronic renal insufficiency (CRI) and renal artery stenosis (RAS) following renal artery (RA) stent placement with and without embolic protection device (EPD) usage.


METHODS
Eighteen patients who had RA stent placement with EPD were matched to control patients (RA stent only). Blood pressure, number of hypertensive medications, and estimated glomerular filtration rate (eGFR) at 3 months before the procedure and after 12 months were determined. An increase of ≥ 20% in eGFR at 12 months from baseline was defined as "improvement," decrease of ≥ 20% as "deterioration," and an eGFR change between those values as "stabilization" at 12 months.


RESULTS
At 12 months, stage 4 patients treated with EPD had significantly higher eGFR than controls (P = .01). There was no statistical difference in blood pressure outcomes between the 2 groups.


CONCLUSIONS
Patients with stage 4 CRI did significantly better with EPD than those treated without it.
Department of Radiology, School of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Ankaj
A
Khosla
Sanjay
S
Misra
Eddie L
EL
Greene
Axel
A
Pflueger
Steve C
SC
Textor
Haraldur
H
Bjarnason
Michael A
MA
McKusick
D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000009:adverse effects / Q000295:instrumentation*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D057505:Embolic Protection Devices; D017700:Embolism, Cholesterol / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008910:Minnesota; D012078:Renal Artery Obstruction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents