Nrf2 as a converging node for cellular signaling pathways of gasotransmitters.
Gasotransmitters is a family of endogenous molecules of gases or gaseous signaling molecules. To date, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H(2)S) have been found to be important gasotransmitters in humans. Three gasotransmitters at high concentrations have been confirmed to be detrimental to human health, while evidence shows they at low concentrations may confer protective effects. There are important interactions among three gasotransmitters. Recent evidence reveals that these gasotransmitters may converge at Nrf2, an important transcription factor able to induce the expressions of some critical antioxidant enzymes, which may attribute to the protective effects of these gasotransmitters. Thus, we hypothesize that Nrf2 serves as a converging node for cellular signaling pathways of gasotransmitters, which adds evidence on the interactions among them.
Department of Diving Medicine, The Second Military Medical University, Shanghai, PR China.
Wenwu
W
Liu
Dong
D
Wang
Kan
K
Liu
Xuejun
X
Sun
D002248:Carbon Monoxide / Q000494:pharmacology; D005740:Gases / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000494:pharmacology; D008962:Models, Theoretical; D051267:NF-E2-Related Factor 2 / Q000096:biosynthesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D005740:Gases; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D002248:Carbon Monoxide; D006862:Hydrogen Sulfide