Churg-Strauss syndrome with a clinical condition similar to IgG4-related kidney disease: a case report.
A 68-year-old Japanese woman with asthma of recent onset and a long history of membranous glomerulonephropathy (MN) was admitted because of multifocal pulmonary infiltrates, marked eosinophilia, mild renal dysfunction, a rash on her feet, and right median nerve paralysis. Although MPO- and PR3-ANCA were negative, skin biopsy demonstrated leukocytoclastic vasculitis and Churg-Strauss Syndrome (CSS) was diagnosed. She also had salivary gland swelling and a high serum IgG4 level. Renal biopsy revealed MN with eosinophil-rich tubulointerstitial nephropathy. Her symptoms resolved after the start of corticosteroid therapy. The present case shows that ANCA-negative CSS can have a clinical condition similar to IgG4-related kidney disease.
Nephrology Center, Toranomon Hospital, Japan.
Nobuhiro
N
Ayuzawa
Yoshifumi
Y
Ubara
Sumida
S
Keiichi
Yamanouchi
Y
Masayuki
Eiko
E
Hasegawa
Eriko
E
Hiramatsu
Noriko
N
Hayami
Tatsuya
T
Suwabe
Junichi
J
Hoshino
Naoki
N
Sawa
Masateru
M
Kawabata
Kenichi
K
Ohashi
Kennmei
K
Takaichi
D000368:Aged; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D007674:Kidney Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis / Q000276:immunology
D007074:Immunoglobulin G