Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities.
Two new triterpenoids and a chromone glycoside, namely, 24-epi-cimigenol-3-one (1), foetinoside (2), cimifugin-4'-O-[6″-feruloyl]-β-D-glucopyranoside (3), together with 18 known compounds, were isolated from the rhizomes of Cimicifuga foetida L. collected in Guizhou Province, China. All of the compounds were identified by spectroscopic methods, as well as chemical methods. In the in vitro cytotoxicity evaluation of these compounds against 5 human cancer cell lines, cimigenol (8) exerted the most potent cytotoxic activity against SMMC-7721 (7.87 µM) and A-549 (12.16 µM), while cimiacerin B (9) also showed obvious cytotoxicity against the A-549 cell line, with an IC(50) value of 16.77 µM.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
Lu
L
Lu
Jian-Chao
JC
Chen
Yan
Y
Li
Chen
C
Qing
Yuan-Yuan
YY
Wang
Yin
Y
Nian
Ming-Hua
MH
Qiu
D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D031885:Cimicifuga / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C575522:24-epi-cimigenol-3-one; D002867:Chromones; D006027:Glycosides; D014315:Triterpenes; C575524:cimifugin-4'-O-(6''-feruloyl)-beta-D-glucopyranoside; C575523:foetinoside