Lessons in nonhuman primate models for AIDS vaccine research: from minefields to milestones.
Nonhuman primate (NHP) disease models for AIDS have made important contributions to the search for effective vaccines for AIDS. Viral diversity, persistence, capacity for immune evasion, and safety considerations have limited development of conventional approaches using killed or attenuated vaccines, necessitating the development of novel approaches. Here we highlight the knowledge gained and lessons learned in testing vaccine concepts in different virus/NHP host combinations.
AIDS and Cancer Virus Program, SAIC Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA.
Jeffrey D
JD
Lifson
Nancy L
NL
Haigwood
D016915:AIDS Vaccines / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D057131:Immune Evasion; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D016915:AIDS Vaccines; D018449:SAIDS Vaccines; D014613:Vaccines, Attenuated