[Isomeric derivatives of lupinine and epilupinine--organophosphorus inhibitors of cholinesterases].
The isomeric-structure analysis data of anticholinesterase action of organophosphorous inhibitors with similar structure help in the search of specific effectors and detection of differences in reactivity of various animals' enzymes. This study compared the data of efficacy in respect of 4 mammal and 5 arthropoda cholinesterase preparations for 26 quinolizidine inhibitors, which molecules contain both the isomeric unbranched and branched alkoxyl radicals in the phosphoryl group, and the epimeric lupinine and epilupinine derivatives in the leaving group. The changes in the alkoxyl radical structure of inhibitor molecules act on their efficacy only with respect to the mammal enzymes ("group" inhibitor specificity). The differences between lupinine and epilupinine derivatives were revealed. Highly specific inhibitors of different enzymes were detected among the tested compounds.
N E
NE
Basova
B N
BN
Kormilitsyn
A Iu
AIu
Perchenok
E V
EV
Rosengart
V S
VS
Saakov
A A
AA
Suvorov
D000438:Alcohols / Q000737:chemistry; D000818:Animals; D001181:Arthropods; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D002802:Cholinesterases / Q000737:chemistry / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes; D007536:Isomerism; D007700:Kinetics; D008322:Mammals; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013034:Sparteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013045:Species Specificity; D013329:Structure-Activity Relationship; D000093843:Quinolizidine Alkaloids
D000438:Alcohols; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases; D007527:Isoenzymes; D009943:Organophosphorus Compounds; D013034:Sparteine; C059688:alkoxyl radical; C015971:lupinine; D000093843:Quinolizidine Alkaloids