[Balance of steroid hormones among children and teenagers with epilepsies].
The level of steroid hormones (cortisol, cortisone, aldosterone) in children with epilepsy, aged from 4 to 18 years, was investigated. The levels of cortisol, cortisone and aldosterone were changed in 58.0%, 32.0% and 62.0% of patients with pharmacoresistant epilepsy, respectively, compared to age-matched controls. In case of epilepsy with positive effect of antiepileptic treatment, the changes of aldosterone were found only in 40.6% of patients. The level of hormones was, to a certain extent, age-dependent only in pharmacoresistant epilepsy. The greatest changes are registered in the following periods: at the age 4-7 years, the cortisone level corresponded to the norm in 33.3%, aldosterone in 44.4%; at the age 12-16 years, the indexes of cortisol corresponded to the norm in 26.7%, aldosterone in 20.0%; at the age 8 − 11 years, only the level of aldosterone was changed, it corresponded to the norm in 35.3% of cases.
G A
GA
Gol'tvanitsa
Iu A
IuA
Shirshov
N A
NA
Marueva
Iu A
IuA
Kritskaia
E V
EV
Leont'eva
I V
IV
Temnikova
D000293:Adolescent; D000450:Aldosterone / Q000097:blood*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000097:blood*; D004351:Drug Resistance; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D016896:Treatment Outcome
D000927:Anticonvulsants; D000450:Aldosterone; D003348:Cortisone; D006854:Hydrocortisone