Ordered mesoporous silica material SBA-15: loading of new calcium channel blocker--lacidipine.
Mesoporous material SBA-15 of hexagonal structure was synthesised and its usefulness as a carrier for a poorly soluble drug--lacidipine (LA)--was tested. The source of silica was tetraethyl orthosilicate (TEOS) and the structure ordering agent was non-ionic surfactant Pluronic P123. SBA-15 with encapsulated LA was characterised by X-ray diffraction (XRD), infrared spectroscopy (FTIR), thermogravimetry (TG), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM). Adsorption of the therapeutically active substance was performed in anhydrous environment (chloroform). The content of the therapeutic substance in SBA-15 estimated from TG measurements reached 9%. The properties of the compound obtained were compared with those of a physical mixture of the components.
Faculty of Physics, A. Mickiewicz University, ul. Umultowska 85, 61-614 Poznań, Poland.
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A
Kiwilsza
J
J
Mielcarek
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Pajzderska
J
J
Wąsicki
D002121:Calcium Channel Blockers / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004095:Dihydropyridines / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D011060:Poloxalene / Q000737:chemistry; D033362:Powder Diffraction; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C509969:SBA-15; C060285:lacidipine; C464484:pluronic block copolymer P123; D012822:Silicon Dioxide; D011060:Poloxalene