[Correction of protein-lipid composition in liver mitochondria during experimental widespread purulent peritonitis].
Experiments performed in a group of 55 chinchilla rabbits showed that the development of widespread purulent peritonitis is accompanied by the expressed changes of protein-lipid structure of liver mitochondria. A comparative analysis of the application of metabolic preparations citoflavin and neoton for the purpose of eliminating pathological deviations in the structure of liver mitochondrian has been carried out. The application of citoflavin more effectively prevents decrease in total phospholipids and cholesterol in mitochondrial membranes. In combination with stimulation of an increase in the amount of protein, this points to high protective properties of this preparation which allow the functional potential of liver mitochondria to be retained under conditions of experimental widespread purulent peritonitis.
V A
VA
Kosinets
S S
SS
Osochuk
N N
NN
Iarotskaia
D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology* / Q000627:therapeutic use; D007290:Inosine Diphosphate / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology* / Q000627:therapeutic use; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D010725:Phosphocreatine / Q000494:pharmacology* / Q000627:therapeutic use; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism; D011506:Proteins / Q000032:analysis / Q000378:metabolism; D011817:Rabbits; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D013492:Suppuration
D004338:Drug Combinations; D010743:Phospholipids; D011506:Proteins; D013386:Succinates; C507879:cytoflavin; D010725:Phosphocreatine; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D002784:Cholesterol