Breathless on bortezomib.
The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition of this complication, which has so far been described in only a handful of patients, but the pattern seen may offer clues to pathogenesis and potential treatments. This case highlights the need for both physicians and patients consenting to bortezomib treatment to be more aware of this potentially fatal adverse effect.
Respiratory Medicine Department, MAHSC at Salford Royal NHS Foundation Trust, Manchester, UK. devaki.o’riordan@srft.nhs.uk
Devaki
D
O'Riordan
John
J
Houghton
Roger
R
Chisholm
B Ronan
BR
O'Driscoll
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001897:Boronic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000069286:Bortezomib; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D011014:Pneumonia / Q000139:chemically induced*; D011719:Pyrazines / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib