Single-nucleotide polymorphisms in inflammatory bowel disease.
Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental factors play important roles. This review discusses several single-nucleotide polymorphisms with either susceptibility or protective effects on inflammatory bowel disease.
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, and In Vitro Drug Safety and Biotechnology, MaRS, Toronto, Ontario, Canada. manuela.neuman@utoronto.ca
Manuela G
MG
Neuman
Radu M
RM
Nanau
D053468:CARD Signaling Adaptor Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D010588:Phagosomes / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics; D057170:Translational Research, Biomedical; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D053468:CARD Signaling Adaptor Proteins; D002352:Carrier Proteins; D018123:Receptors, Interleukin; D014409:Tumor Necrosis Factor-alpha; D046988:Proteasome Endopeptidase Complex