Host-gut microbiota metabolic interactions.
The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. j.nicholson@imperial.ac.uk
Jeremy K
JK
Nicholson
Elaine
E
Holmes
James
J
Kinross
Remy
R
Burcelin
Glenn
G
Gibson
Wei
W
Jia
Sven
S
Pettersson
D000375:Aging; D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D004032:Diet; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000382:microbiology*; D006262:Health; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism / Q000382:microbiology*; D053858:Metabolic Networks and Pathways; D054892:Metagenome; D015398:Signal Transduction