Strategies for targeting the DNA damage response for cancer therapeutics.
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
Dan
D
Zhang
Hai-Bo
HB
Wang
Kathryn L
KL
Brinkman
Su-Xia
SX
Han
Bo
B
Xu
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016923:Cell Death; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004307:Dose-Response Relationship, Radiation; D019008:Drug Resistance, Neoplasm; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000494:pharmacology; D011829:Radiation Dosage
D000970:Antineoplastic Agents; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases