[Clinical and cytogenetic analyses of 45 adult patients with acute lymphoblastic leukemia].
OBJECTIVE
To analyze the correlation between clinical features and cytogenetic finding of 45 adult patients with acute lymphoblastic leukemia (ALL), and to assess the value of chromosomal examination for the diagnosis and prognosis.


METHODS
Fluorescence in situ hybridization (FISH) was utilized for detecting the BCR/ABL fusion gene and P53 gene. Median survival time (MST) of patients was compared using Log-rank test.


RESULTS
Respectively, the MST of patients with white blood cell count (WBC) ≤30 × 10(9)/L, normal karyotype, or without a Philadelphia chromosome were significantly greater than those with WBC > 30 × 10(9)/L, abnormal karyotype or Philadelphia chromosome (P< 0.05).


CONCLUSIONS
WBC, karyotype abnormalities and presence of Philadelphia chromosome are independent factors for the prognosis of ALL in adult patients.
Department of Hematology, The Second People's Hospital of Changzhou Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China.
Ling
L
Cen
Min
M
Zhou
Tao
T
Chen
Rong
R
Xiao
Jian-he
JH
Yang
Nai-ke
NK
Jiang
Yan
Y
Zhang
Xu-zhang
XZ
Lu
D059786:Abnormal Karyotype; D000328:Adult; D000368:Aged; D020732:Cytogenetic Analysis / Q000379:methods; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics*
D016044:Fusion Proteins, bcr-abl