Human carcinogenesis and alcohol in hepato-gastroenterology.
Alcohol consumption is one of the top-10 risks for worldwide burden of disease. The International Agency for Research for Cancer affirmed that there was evidence for the carcinogenicity of ethanol in animals and classified alcohol consumption as carcinogenic for humans. Alcohol consumption causes cancers of the oral cavity, pharynx, larynx, oesophagus, colorectum, liver, pancreas and female breast. Most alcohol-induced diseases increases in a linear fashion as intake increases: oral, oesophagus and colon cancer fall into this pattern: very little is known about safe margins of alcohol consumption. Given the linear dose-response relation between alcohol intake and risk of cancer, control of heavy drinking remains the main target for cancer control. European Code Against Cancer recommends keeping daily consumption within two drinks (20 g [corrected] of alcohol/day) for man and one drink for women and US Department of Health and Human Services suggest as a low risk, a maximum of 10 g [corrected] of alcohol a day in man and half of this in women.
Department of Specialistic Medicine, S. Martino Hospital, Genova, Italy. gianni.testino@hsanmartino.it
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D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology / Q000517:prevention & control; D000818:Animals; D001628:Beverages; D002471:Cell Transformation, Neoplastic; D004067:Digestive System Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D018673:Nutrition Policy; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D012737:Sex Factors
D000431:Ethanol