Characteristics of HIV-positive patients infected by vertical transmission, Campo Grande, MS, Brazil, 1993-2009.
OBJECTIVE
The goal of the authors was to determine the epidemiological and clinical characteristics of all HIV-positive children and adolescents infected by vertical transmission.


METHODS
A descriptive, cross-sectional and retrospective study was conducted that included all HIV-positive patients infected by vertical transmission who attended the referral services of the municipality of Campo Grande from 1993 to 2009, and who used antiretrovirals (ARV). The data were collected from medical records after local institutional review board approval.


RESULTS
78 patients were included, and almost half of the living patients (75) in 2009 were 11-15 years of age. The average age at diagnosis was 38.8 months, treatment was most often initiated from 12 to 35 months of age, and HAART was the most common treatment. Most patients (51.3%) were hospitalised between one and five times, and the first regimen was not associated with hospitalisation (p=0.2). The majority of patients did not exhibit virological suppression at the last examination, and genotyping revealed the presence of resistance mutations. Failure of therapy was often the result of non-adherence to therapy. Five patients died, and the causes of death were pneumonia, sepsis, cerebral cryptococcosis and myocarditis.


CONCLUSIONS
Despite the availability of drugs and appropriate laboratory tests, a significant number of paediatric patients were failing ARV therapy due to non-adherence. Further interventions to enhance adherence in this population are needed.
1Section of Hospital Pharmacy, University Medical Centre, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil. vanematos@ibest.com.br
Vanessa Terezinha Gubert
VT
de Matos
Ana Lúcia Lyrio
AL
de Oliveira
Albert Schiaveto
AS
de Souza
Márcia Maria Ferrairo Janini
MM
Dal Fabbro
D000293:Adolescent; D019380:Anti-HIV Agents / Q000008:administration & dosage; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult; D016903:Drug Monitoring
D019380:Anti-HIV Agents