Characteristics of pelvic lymph node metastases in prostatic adenocarcinoma: a study of 83 cases.
Pelvic lymph node dissection (PLND) is currently the most accurate staging modality for lymph node metastases in prostate adenocarcinoma. There is no consensus on the optimal sampling method of PLND specimens among pathologists. This study analyzed the effectiveness of the submission of entire adipose tissue in 451 cases and its impact on total lymph node yield and detection of positive lymph nodes. The sizes of metastatic foci and positive lymph nodes in 83 cases were also studied. Submission of entire adipose tissue increased the lymph node yield and positive lymph node detection by 36.7 % and 1.99 %, respectively. Three cases had positive lymph nodes exclusively in adipose tissue. Of the patients examined, 68% had the largest positive lymph node, <1 cm. In conclusion, it was noted that metastases from prostate cancer were frequently small and seen within small lymph nodes. Submission of entire adipose tissue substantially increased the lymph node yield, but its impact on the detection of additional positive lymph nodes was low. Submission of the entire adipose tissue may be considered as an option in patients with high-risk factors for lymph node metastases.
Department of Pathology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Ji Yoon
JY
Yoon
Oleksandr N
ON
Kryvenko
Khurshid R
KR
Ghani
Chad
C
Bertucci
Mani
M
Menon
Nilesh S
NS
Gupta
D000230:Adenocarcinoma / Q000556:secondary*; D000273:Adipose Tissue / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D010388:Pelvis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies