Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation.
SULF1/SULF2 enzymes regulate the activities of several growth factors by selective hydrolysis of 6-O-sulphates of heparan sulphate proteoglycan co-receptors, the sulfation of which is essential for signal transduction of some ligand/receptor interactions but not others. This study demonstrates the existence of SULF1 variants with a wide spectrum of splicing patterns in mammalian tumours. The levels and relative proportions of SULF1/SULF2 splice variants markedly vary in different tumours with a potential to regulate cell growth differentially. Although mammalian Sulf1 compared with Sulf2 gene generates a much larger number of splice variants, both enzymes follow generally similar distribution and signalling association trends in hepatocellular carcinomas.
Department of Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW1 OTU, UK.
Rai B S
RB
Gill
Amy
A
Day
Amy
A
Barstow
Gul
G
Zaman
Chantal
C
Chenu
Gurtej K
GK
Dhoot
D017398:Alternative Splicing; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006801:Humans; D007527:Isoenzymes; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D015238:Sulfotransferases / Q000235:genetics* / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
D007527:Isoenzymes; D051153:Wnt Proteins; D015238:Sulfotransferases