4-aminoquinazoline analogs: a novel class of anticancer agents.
4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.
Dr. K.N. Modi Institute of Pharmaceutical Education and Research, Modinagar-201201, U.P., India.
Kalpana
K
Singh
P P
PP
Sharma
A
A
Kumar
Anurag
A
Chaudhary
R K
RK
Roy
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D055808:Drug Discovery / Q000639:trends*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use
C573775:4-aminoquinazoline; D000970:Antineoplastic Agents; D011799:Quinazolines; D066246:ErbB Receptors