Roles of cADPR and NAADP in pancreatic cells.
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca(2+)-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca(2+) signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.
Department of Physiology,  The University of Hong Kong, Hong Kong,  China.
Yongjuan
Y
Zhao
Richard
R
Graeff
Hon Cheung
HC
Lee
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D036563:Cyclic ADP-Ribose / Q000378:metabolism / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008954:Models, Biological; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology; D010179:Pancreas / Q000166:cytology / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology
D036563:Cyclic ADP-Ribose; D009249:NADP; C024376:NAADP; D051997:ADP-ribosyl Cyclase 1; D002118:Calcium