NHC-catalyzed C-O or C-N bond formation: efficient approaches to α,β-unsaturated esters and amides.
Simple and efficient NHC-catalyzed transformations of bromoenal or α,β-dibromoenal into α,β-unsaturated esters or amides with high stereoselectivity through C-O or C-N bond formation have been demonstrated. The NHC-catalyzed processes occur under mild conditions. The ready availability of the starting materials, avoidance of external oxidants and the usefulness of the products all make the strategy attractive.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China.
Bo
B
Zhang
Peng
P
Feng
Yuxin
Y
Cui
Ning
N
Jiao
D000577:Amides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D013237:Stereoisomerism
D000577:Amides; D004952:Esters; D006571:Heterocyclic Compounds; C030011:carbene; D002244:Carbon; D009584:Nitrogen; D008697:Methane; D010100:Oxygen