Serum cotinine and prognosis in breast cancer.
Various studies have suggested that women who smoke have a worse prognosis if they develop breast cancer. Cotinine levels have been measured in sera from 511 patients with stage I and II breast cancer diagnosed between 1975 and 1980, all of whom had complete follow-up. Although the known prognostic factors, axillary nodal status, tumour size and grade were found to be significant, there was no relationship between serum cotinine and metastasis-free survival. A point estimate of serum cotinine was not found to be a determinant of survival in women with early breast cancer.
Research Oncology, Kings College London, Guy's Hospital, 3rd Floor Bermondsey Wing, London, SE1 9RT, UK.
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L
Johnson
O
O
Agbaje
M
M
Doig
I S
IS
Fentiman
D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology*; D015331:Cohort Studies; D003367:Cotinine / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000097:blood
D003367:Cotinine