[Effect of glucosamine hydrochloride in combination with paracetamol on chondrocyte apoptosis under conditions of systemic steroidal arthritis development in rats].
The effect of a combination of glucosamine hydrochloride with paracetamol on the apoptosis of chondrocytes in the articular cartilage of rats with experimental steroidal dystrophy (osteoarthritis) has been studied by hystochemical methods. Untreated control rats are characterized by a significant increase in the fraction of chondrocytes involved in the processes of apoptosis. The treatment of animals by a combination of glucosamine hydrocloride with paracetamol substantially reduced the percentage of apoptic chondrocytes. The pronounced antiapoptic effect of the investigated combination differed but little from the effect of glucosamine hydrochloride alone, but significantly exceeded the antiapoptic activity of paracetamol.
I A
IA
Zupanets
V A
VA
Tuliakov
S K
SK
Shebeko
D000082:Acetaminophen / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D019902:Chondrocytes / Q000378:metabolism* / Q000473:pathology; D005944:Glucosamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D005944:Glucosamine