Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents.
OBJECTIVE
Short leukocyte telomere length (LTL) is associated with cardiovascular (CV) disease in adulthood. However, the biological basis of this association remains unclear. We sought to define early determinants of the association between CV disease and LTL in an adolescent population.


RESULTS
One thousand eighty adolescents, aged 13 to 16 years and participating in the Ten Towns Heart Health Study, provided blood samples for DNA extraction and measurement of a range of CV risk factors. LTL was measured by real-time polymerase chain reaction. LTL was inversely associated with age (P=0.04), longer in females than in males (P=0.03), and longer in South Asians than in white Europeans (P=0.01). No associations were found between LTL and traditional CV risk factors. There was a significant and inverse association between LTL and inflammatory markers, including C-reactive protein (P<0.001) and fibrinogen (P=0.001). The associations between LTL and inflammatory markers were not affected by multiple adjustments for behavioral and metabolic factors.


CONCLUSIONS
High levels of inflammation are associated with shorter LTL from early adolescence; traditional CV risk factors have little association with LTL in adolescence. Inflammation in early life may play a causal role in the adult association between short LTL and CV disease.
Vascular Physiology Unit, Institute of Cardiovascular Science, UCL, 34 Great Ormond St, London WC1N 1JE, UK. s.masi@ucl.ac.uk
Stefano
S
Masi
Claire M
CM
Nightingale
Ian N M
IN
Day
Philip
P
Guthrie
Ann
A
Rumley
Gordon D O
GD
Lowe
Thomas
T
von Zglinicki
Francesco
F
D'Aiuto
Stefano
S
Taddei
Nigel
N
Klein
Klelia
K
Salpea
Derek G
DG
Cook
Steve E
SE
Humphries
Peter H
PH
Whincup
John E
JE
Deanfield
D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics*; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D012307:Risk Factors; D016615:Telomere
D002097:C-Reactive Protein