Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer.
Laboratory of Medicinal Chemistry, Endocrinology and Genomic Unit, CHUQ-CHUL Research Center, 2705 Boulevard Laurier, Québec G1V 4G2, Canada.
Diana
D
Ayan
René
R
Maltais
Donald
D
Poirier
D015094:3-Hydroxyacyl CoA Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000544:Alzheimer Disease / Q000201:enzymology* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008968:Molecular Conformation; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000378:metabolism; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D013256:Steroids; D015094:3-Hydroxyacyl CoA Dehydrogenases; C108634:HSD17B10 protein, human