Tenascin-C in human cardiac pathology.
Tenascin-C (TN-C), a hexameric extracellular matrix glycoprotein, is a pleiotropic regulator of a variety of cell functions associated with embryogenesis, wound healing, cell proliferation, differentiation, motility, and nerve regeneration. Due to its role in remodeling processes, TN-C is involved with many pathologic states including cardiac and vascular diseases as well as inflammation and cancer. Assessment of circulating TN-C may help with identification of heart disease, especially in conjunction other cardiac biomarkers. It may be considered a specific biomarker useful in detecting cardiac pathology, especially in early disease stages and subsequent monitoring of cardiologic therapy. This review will highlight the biochemistry and usefulness of TN-C in clinical laboratory diagnostics to date.
Neuromuscular Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw 02-106, Poland. dobosz@cmdik.pan.pl
Irena
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Niebroj-Dobosz
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000235:genetics / Q000473:pathology; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D019063:Tenascin / Q000097:blood* / Q000235:genetics; D014945:Wound Healing
D015415:Biomarkers; D005353:Fibronectins; D019063:Tenascin