Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis.
A small library of cell-penetrating peptides (CPPs) containing a minimized cationic domain and a lipophilic domain of different size was studied. CPPs that could self-assemble were found to enter cells more efficiently, triggering a glycosaminoglycan-dependent pathway.
UPMC Univ Paris 06, UMR 7203, LBM, F-75005, Paris, France.
Saskia A
SA
Bode
Marion
M
Thévenin
Chérine
C
Bechara
Sandrine
S
Sagan
Sarah
S
Bregant
Solange
S
Lavielle
Gérard
G
Chassaing
Fabienne
F
Burlina
D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism*; D006224:Cricetinae; D004705:Endocytosis; D006025:Glycosaminoglycans / Q000378:metabolism*; D008969:Molecular Sequence Data; D019151:Peptide Library; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*
D057846:Cell-Penetrating Peptides; D006025:Glycosaminoglycans; D019151:Peptide Library; D047428:Protein Kinase Inhibitors