Polycyclic polyprenylated acylphloroglucinols and cytotoxic constituents of Hypericum androsaemum.
Two new polycyclic polyprenylated acylphloroglucinols (PPAPs), androforin A and hyperandrone A, together with twelve known compounds, were isolated from the aerial parts of Hypericum androsaemum. Their structures were established by detailed spectral analysis. In the cytotoxic assay, 1,4-O-diferuloylsecoisolariciresinol showed activities comparable with those of cisplatin, and acetyloleanolic acid exhibited moderate inhibitory effects against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cancer cell lines.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Kou
K
Wang
Yuan-Yuan
YY
Wang
Xiu
X
Gao
Xuan-Qin
XQ
Chen
Li-Yan
LY
Peng
Yan
Y
Li
Gang
G
Xu
Qin-Shi
QS
Zhao
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D011083:Polycyclic Compounds / Q000737:chemistry*
D011083:Polycyclic Compounds; C575708:androforin A; C575709:hyperandrone A; D010696:Phloroglucinol