Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate.
The enzyme-guided asymmetric synthesis of (+)-verbenone from geranyl diphosphate in a simple two-step, one pot transformation highlights the potential of chemoenzymatic procedures for the generation of high-value terpenoids.
School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom.
Zulfa
Z
Yoosuf-Aly
Juan A
JA
Faraldos
David J
DJ
Miller
Rudolf K
RK
Allemann
D000081008:Bicyclic Monoterpenes; D003500:Cyclization; D011756:Diphosphates / Q000737:chemistry / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D019753:Intramolecular Lyases / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
D000081008:Bicyclic Monoterpenes; D011756:Diphosphates; D004224:Diterpenes; D013729:Terpenes; C511282:geranyl diphosphate; C052875:verbenone; D019753:Intramolecular Lyases; C040265:pinene cyclase I