[Population-related peculiarities of molecular stress-responsive systems of bivalve mollusk under the effect of tetrazine pesticide].
Tetrazine pesticides are widely used for the treatment of crops in most EU countries and USA. However, data about the effect of environmentally realistic concentrations of biocides on the molecular stress response system in non-target organisms are absent. The aim of our study was the comparison of adaptive capability of bivalve mollusk Anodonta cygnea from two populations under the effects of commercial pesticide Apollo in terms of biochemical parameters of the digestive gland. The differences between parameters of oxidative stress and glutathione transferase activity in specimens of control groups from clean (I group) and polluted (B group) areas have been shown. Under the effect of Apollo, the level of protein carbonyls and microsomal oxidation processes increased, and the level of metallothioneins and oxyradical formation decreased in the specimens from both populations. However, the treatment provoked the activation of antioxidant processes in the I group and their inhibition in B group. Potentially the injury of cellular thiols, glutathione and metallothioneins, seems to be key point of tetrazine pesticides toxicity.
H I
HI
Fal'fushins'ka
L L
LL
Hnatyshyna
O B
OB
Stoliar
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D049872:Bivalvia / Q000187:drug effects* / Q000378:metabolism; D002722:Chlorobenzenes / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D004784:Environmental Monitoring; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D008668:Metallothionein / Q000037:antagonists & inhibitors / Q000378:metabolism; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D010575:Pesticides / Q000633:toxicity*; D050050:Protein Carbonylation / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D000975:Antioxidants; D002722:Chlorobenzenes; D010575:Pesticides; D013438:Sulfhydryl Compounds; D014874:Water Pollutants, Chemical; D008668:Metallothionein; D005982:Glutathione Transferase; D005978:Glutathione; C062106:clofentezine