Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease.
BACKGROUND
Patients with Parkinson's disease (PD) may develop freezing of gait (FOG) with chronic deep brain stimulation (DBS) of the subthalamic nucleus (STN) at the commonly used frequency of 130 Hz and FOG can be ameliorated by 60 Hz stimulation in some patients. It is not clear whether the development of FOG is due to the disease progression or the chronic stimulation at this 130 Hz frequency.


OBJECTIVE
To investigate the effect of stimulation frequency on immediate FOG in newly activated STN DBS patient with PD and determine if stimulation frequency alone could affect the FOG.


METHODS
Two cases of PD who developed FOG immediately upon activation of the newly placed STN DBS were studied for the effect of stimulation frequency on FOG in both `off' and `on' medication status.


RESULTS
Both patients developed severe FOG with the commonly used 130 Hz stimulation. Switching the frequency to 60 Hz immediately alleviated the FOG, without change in contacts, voltages and pulse widths. This frequency effect on FOG was present in both `off' and `on' statuses and remained effective during the 10-month follow-up period.


CONCLUSIONS
These two cases demonstrate that lower frequency stimulation of 60 Hz could improve FOG, while the commonly used 130 Hz stimulation could cause FOG or make it worse. In addition, the beneficial effect of low frequency DBS was additive to dopaminergic medication effect and included other axial symptoms.
Department of Neurology, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 2030, Chicago, IL 60637, USA. txie@bsd.uchicago.edu
Tao
T
Xie
Un Jung
UJ
Kang
Peter
P
Warnke
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000379:methods*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D004567:Electrodes, Implanted; D005260:Female; D005684:Gait; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D018476:Hypokinesia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000978:Antiparkinson Agents; D018491:Dopamine Agonists