Cardiovascular risk assessment in children following kidney transplantation.
CV diseases are the leading cause of death among patients with ESRD. RTX decreases the CV risk; however, it still remains definitely higher than that of the general population. Large multicenter and longitudinal studies are difficult to perform and hard end-points of CV events are usually missing among pediatric population. Thus, appropriate estimation of CV risk is of crucial importance to define the potential hazards and to evaluate the effect of treatments aimed to reduce the risk. A number of validated non-invasive methods are available to assess the extent of CV damage in adults, such as calcification scores, cIMT, aPWV, 24-h ABPM, AASI, and HRV; however, they need adaptation, standardization, and validation in pediatric studies. cIMT and PWV are the most promising methods, as pediatric normative values are already present. The up-to-date treatment of ESRD aims not only to save life, but to offer the patient a life expectancy approaching that of the healthy population and to ensure a reasonable quality of life.
First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
Arianna
A
Dégi
Andrea
A
Kerti
Eva
E
Kis
Orsolya
O
Cseprekál
Kálmán
K
Tory
Attila J
AJ
Szabó
George S
GS
Reusz
D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis*; D059168:Carotid Intima-Media Thickness; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008137:Longitudinal Studies; D010372:Pediatrics / Q000379:methods; D011788:Quality of Life; D012107:Research Design; D018570:Risk Assessment / Q000379:methods*; D061205:Vascular Calcification / Q000150:complications