[A possible analgesic effect of nicotine on postoperative pain].
Since postoperative pain often is undermanaged, and opioids, although being efficient analgesics, have undesirable side effects, attention has turned towards adjuvant therapies, among them nicotine. We present seven studies of which six show an effect of nicotine on postoperative pain when given in a low dose, with short time of exposure and to non-smokers. Other possible confounders are gender and type of anaesthesia. Nicotine seems to increase the occurrence of nausea and vomiting. More research is needed, and nicotine cannot currently be recommended as part of a multimodal pain management regime.
Anæstesiologisk Afdeling, Sydvestjysk Sygehus Esbjerg, Finsensgade 35, 6700 Esbjerg, Denmark. sannevibenielsen@hotmail.com
Sanne
S
Vibe Nielsen
Rasmus Hjelmar
RH
Petersen
Andra
A
Pachai
D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy*; D012737:Sex Factors; D012907:Smoking
D000700:Analgesics; D009538:Nicotine