Hemimandibulectomy after bisphosphonate treatment for complex regional pain syndrome: a case report and review on the prevention and treatment of bisphosphonate-related osteonecrosis of the jaw.
BACKGROUND
The increase in reported cases of osteonecrosis of the jaw has increased the clinical significance of bisphosphonate therapeutic agents in the dentistry field.


METHODS
We present a rare and severe case of bisphosphonate-related osteonecrosis of the jaw caused by medicamentous treatment of complex regional pain syndrome. This article reviews the current international prevention and treatment guidelines with regard to bisphosphonate treatment.


RESULTS
Even rare indications for bisphosphonate treatment may lead to devastating effects on the patient.


CONCLUSIONS
Dentists and physicians who prescribe bisphosphonates should be familiar with the side effects of these drugs and the management of these side effects. To prevent negative outcomes, it is important that there be a close collaboration among the doctors involved and that a thorough medical history is obtained; this is especially true because the range of indications for bisphosphonate treatment increases every year.
Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Würzburg, Germany.
Thomas
T
Bittner
Natascha
N
Lorbeer
Tobias
T
Reuther
Hartmut
H
Böhm
Alexander C
AC
Kübler
Urs D A
UD
Müller-Richter
D000328:Adult; D000818:Animals; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery*; D001733:Bites and Stings / Q000150:complications; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D016025:Bone Transplantation; D002921:Cicatrix / Q000209:etiology / Q000601:surgery; D017742:Dental Care for Chronically Ill / Q000379:methods*; D004285:Dogs; D005157:Facial Pain / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008334:Mandible / Q000601:surgery*; D019647:Oral Surgical Procedures / Q000379:methods; D010348:Patient Care Team; D019651:Plastic Surgery Procedures / Q000379:methods; D012019:Reflex Sympathetic Dystrophy / Q000188:drug therapy* / Q000209:etiology; D014081:Tooth Extraction / Q000009:adverse effects*
D050071:Bone Density Conservation Agents