Insulin-like growth factor 1 physiology: lessons from mouse models.
Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly regulated and it plays significant roles during early development, maturation, and adulthood. This article discusses the roles of IGF-1 in determination of body size, skeletal acquisition, muscle growth, carbohydrate metabolism, and longevity, as learned from mouse models.
Department of Basic Science and Craniofacial Biology, David B. Kriser Dental Center, New York University College of Dentistry, New York, NY 10010-4086, USA. sy1007@nyu.edu
Shoshana
S
Yakar
Martin L
ML
Adamo
D000818:Animals; D049628:Body Size / Q000502:physiology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007335:Insulin-Like Growth Factor II / Q000502:physiology; D050356:Lipid Metabolism; D008136:Longevity / Q000502:physiology; D008297:Male; D051379:Mice; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000502:physiology; D012098:Reproduction / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
C513121:IGF2 protein, mouse; C519530:insulin-like growth factor-1, mouse; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II