Hippocampal sequences link past, present, and future.
Disrupting the reactivation of hippocampal neurons during sleep impairs memory consolidation in rats. However, the functional importance of reactivation during awake states is unknown. An experiment in which awake reactivation was disrupted suggests that this phenomenon could adaptively guide behavior by linking previous learning with the current state of the world.
Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Andrew M
AM
Wikenheiser
A David
AD
Redish
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D013028:Space Perception / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*