Relationship between myeloid-related protein 8/14 and survival of Chinese peritoneal dialysis patients.
BACKGROUND
Myeloid-related protein 8/14 (MRP8/14) is released by cells of myeloid lineage upon inflammatory challenges. Experimental data suggested that MRP8/14 is important in the initiation and progression of inflammation and cardiovascular diseases. We examined the relation between serum MRP8/14 level and cardiovascular disease in Chinese peritoneal dialysis (PD) patients.


METHODS
We studied 102 new PD patients (58 males, mean age 57.3 ± 11.9 years). Baseline serum MRP8/14 was determined and grouped to quartiles for analysis. All patients were then followed for an average of 23.9 ± 6.9 months.


RESULTS
There was a trend of lower 3-year cardiovascular event-free survival for patient quartiles with high serum MRP8/14 levels (log-rank test, p = 0.064). The 3-year actuarial survival was significantly lower for quartile groups with higher MRP8/14 levels (96.0, 94.7, 72.9, and 62.5% for quartiles 1-4, respectively, p = 0.003). Cox regression analysis showed that serum MRP8/14 level and Kt/V were independent predictors of actuarial survival; in this model, every 1 µg/ml increase in serum MRP8/14 level confers a 25.1% increase in risk of death (95% confidence interval, 1.3-54.4%, p = 0.037). There was no significant difference in technique survival between the MRP8/14 quartile groups.


CONCLUSIONS
A high baseline serum MRP8/14 level was associated with a lower actuarial survival in Chinese PD patients. The pathogenic role of MRP8/14 in the cardiovascular disease of PD patients needs further investigation.
Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Peter Yam-Kau
PY
Poon
Cheuk-Chun
CC
Szeto
Bonnie Ching-Ha
BC
Kwan
Kai-Ming
KM
Chow
Chi-Bon
CB
Leung
Philip Kam-Tao
PK
Li
D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D015415:Biomarkers / Q000097:blood; D040501:Calgranulin A / Q000097:blood*; D040502:Calgranulin B / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000401:mortality* / Q000639:trends
D015415:Biomarkers; D040501:Calgranulin A; D040502:Calgranulin B