Lymphocyte choriomeningitis virus plays hide-and-seek with type 1 interferon.
In this issue, Macal et al. (2012); Walsh et al. (2012), and Wang et al. (2012) examine how adaptive immune responses to acute and chronic lymphocyte choriomeningitis virus infection are regulated by type 1 interferon produced early during infection by different cell types upon activation by intracellular nucleic acid sensors.
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. trinchig@mail.nih.gov
Giorgio
G
Trinchieri
D000818:Animals; D003713:Dendritic Cells / Q000821:virology*; D006801:Humans; D007836:Lassa virus / Q000502:physiology*; D008217:Lymphocytic choriomeningitis virus / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D051199:Toll-Like Receptor 7 / Q000378:metabolism*; D053585:Virus Attachment
D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D051199:Toll-Like Receptor 7