[Effect of succinate- and methionine-containing drug runihol on reparative regeneration processes in liver under experimental hepatectomy conditions].
The effect of runihol and ademethionine on the processes of reparative regeneration in the liver has been experimentally studied in a group of 78 white male rats subjected to partial hepatectomy, in comparison to intact and drug-untreated operated control animals. The administration of ademethionine and runihol within the first four days after operation led to a decrease in the relative area of discomplexation in liver beams and the appearance of prerequisites of the activation of regeneration processes. A morphometric investigation showed that ademethionine stimulated intracellular regeneration reactions on all terms after the partial extirpation of liver, the most pronounced effect being observed on the 4th and 10th days, while the administration of runihol led to comparable effects only on the 14th day. The activation of regeneration processesin the liver parenchyma is retained after cancellation of the preparations.
D S
DS
Sukhanov
T I
TI
vinogradova
A Iu
AIu
Petrov
N V
NV
Zabolotnykh
A L
AL
Kovalenko
S N
SN
Vasil'eva
M G
MG
romantsov
D000818:Animals; D006498:Hepatectomy; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D051381:Rats; D019802:Succinic Acid / Q000494:pharmacology*; D013997:Time Factors
D019802:Succinic Acid; D008715:Methionine