A case of congenital corneal anesthesia with hypopyon in china.
OBJECTIVE
To report a case of congenital corneal anesthesia (CCA) associated with hypopyon and tactile hypoesthesia.


METHODS
Case report.


RESULTS
A 3-year-old girl presented with redness and mild photophobia in the left eye accompanied by corneal ulcer, hypopyon, and corneal neovascularization. Corneal sensation was reduced bilaterally. She exhibited an absence of normal response to painful stimuli. She also had extensive ulceration of the lateral borders and tip of the tongue. The left corneal biopsy revealed negative cultures for bacteria and fungi. She was treated with human amniotic membrane transplantation in the left eye. The response to treatment was good.


CONCLUSIONS
This is the first case of CCA reported in China. CCA is often misdiagnosed as infectious keratitis. Amniotic membrane transplantation is effective in repairing the severe corneal ulcer which may be associated with CCA.
Department of Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Jianwen
J
Tan
Chaoran
C
Zhang
D000650:Amnion / Q000637:transplantation*; D002675:Child, Preschool; D002681:China; D003315:Cornea / Q000098:blood supply; D003320:Corneal Ulcer / Q000601:surgery*; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000151:congenital*; D015863:Iridocyclitis / Q000151:congenital* / Q000601:surgery; D007634:Keratitis / Q000175:diagnosis; D009389:Neovascularization, Pathologic / Q000175:diagnosis; D014945:Wound Healing