Lamotrigine-induced toxic epidermal necrolysis in a young epileptic.
A 20-year-old young female presented with extensive skin rashes with bullae and extensive epidermal necrolysis about 20 days after the addition of lamotrigine (LTG) to her anticonvulsant medication. The patient was managed by stopping LTG and supportive treatment. The seizures were controlled with increase in the doses of carbamazepine. The report emphasises exercising of caution once LTG is added to a regimen containing valproic acid.
Department of Internal and Pulmonary Medicine, SheriKashmir Institute of Medical Sciences, Srinagar, India.
Fayaz A
FA
Sofi
Parvaiz A
PA
Koul
Showkat A
SA
Mufti
G N
GN
Dhobi
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine