RNA in centrosomes: structure and possible functions.
A novel RNA was detected in the centrosomes of Spisula solidissima mollusk oocytes in 2006. This RNA was named centrosomal RNA (cnRNA); five different cnRNAs were described. During the sequencing of the first transcript, cnRNA 11, it was discovered that the transcript contained a conserved structure--a reverse transcriptase domain. In a 2005 study, we speculated about several possible mechanisms for determining the most important functions of centrosomal structures and referred to one of them as an "RNA-dependent mechanism". The discovery of RNA specific to the centrosome is indirect evidence of the centrosomal hypothesis of cellular aging and differentiation. The presence of a reverse transcriptase domain in this type of RNA, together with its uniqueness and specificity, makes the centrosome a place of information storage and reproduction.
I. Beritashvili Center Experimental Biomedicine, 14 Gotua Street, 0160, Tbilisi, Georgia. chichinadze@biphysiol.ge
Konstantin
K
Chichinadze
Ann
A
Lazarashvili
Jaba
J
Tkemaladze
D000818:Animals; D049872:Bivalvia / Q000737:chemistry / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics; D018385:Centrosome / Q000737:chemistry* / Q000502:physiology*; D012313:RNA / Q000737:chemistry* / Q000235:genetics*
D012313:RNA