REV-ERBs: more than the sum of the individual parts.
REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.
Department of Molecular Biology, Sciences III, University of Geneva, 1211 Geneva, Switzerland.
Markus
M
Stratmann
Ueli
U
Schibler