[Effect of mexidol on the development of the phenomenon of the neuronal excitotoxicity in vitro].
Effect of mexidol on the development of the phenomenon of the excitotoxic syndrome in vitro has been studied. Mexidol inhibits in vitro the development of glutamate-induced neurotoxicity, ascorbate-dependent (non-enzymatic) and NADPH₂-dependent (enzymatic) iron-induced lipid peroxide oxidation, is able in high concentrations to bind superoxide anion-radical, significantly increases the activity of Se-dependent glutathione peroxidase, decreases the activity of induced NO-synthase and does not impact on the activity of glutathione-SH-transferase, catalase and neuronal NO-synthase. These effects underlie the antioxidant and antihypoxic action of the drug.
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Shchul'kin
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005971:Glutamates / Q000633:toxicity; D005979:Glutathione Peroxidase / Q000096:biosynthesis; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009498:Neurotoxins / Q000633:toxicity; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D013481:Superoxides / Q000037:antagonists & inhibitors
D000975:Antioxidants; D005971:Glutamates; D009498:Neurotoxins; D010847:Picolines; D013481:Superoxides; C070020:emoxypine succinate; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D052247:Nitric Oxide Synthase Type II