Combined procedure of vascularized bone marrow transplantation and mesenchymal stem cells graft - an effective solution for rapid hematopoietic reconstitution and prevention of graft-versus-host disease.
Hematopoietic stem cell transplantation (HSCT) is a a standard therapeutic option for several diseases. The success of the procedure depends on quality and quantity of transplanted cells and on stromal capacity to create an optimal microenvironment, that supports survival and development of the hematopoietic elements. Conditions associated with stromal dysfunction lead to slower/insufficient engraftment and/or immune reconstitution. A possible solution to this problem is to realize a combined graft of hematopoietic stem cells along with the medular stroma in the form of vascularized bone marrow transplant (VBMT). Another major drawback of HSCT is the risk of graft versus host disease (GVHD). Recently, mesenchymal stromal cells (MSC) have demonstrated the capacity to down-regulate alloreactive T-cell and to enhance the engraftment. Cotransplantation of MSC could be a therapeutic option for a better engraftment and GVHD prevention.
Colţea Hospital, 1 IC Bratianu Ave., Bucharest 030171, Romania. andreicolita@yahoo.com
Andrei
A
Coliţă
Anca
A
Coliţă
Dragos
D
Zamfirescu
Anca Roxana
AR
Lupu
D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D008962:Models, Theoretical