Load-bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo.
In this study, a newly developed Mg-Ca-Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4-, 8-, and 16- week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg-Ca-Zn alloy appears to be safe for human use.
Department of Mechanical Engineering, Korea University, Seongbuk, Anam-dong, Seoul, Republic of Korea.
Sung Youn
SY
Cho
Soo-Won
SW
Chae
Kui Won
KW
Choi
Hyun Kwang
HK
Seok
Hyung Seop
HS
Han
Seok Jo
SJ
Yang
Young Yul
YY
Kim
Jong Tac
JT
Kim
Jae Young
JY
Jung
Michel
M
Assad
D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry*; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D013314:Stress, Mechanical; D055114:X-Ray Microtomography; D015032:Zinc / Q000737:chemistry*
D000497:Alloys; D008274:Magnesium; D015032:Zinc; D002118:Calcium