Longevity and the long arm of epigenetics: acquired parental marks influence lifespan across several generations.
A recent study reported that longevity in Caenorhabditits elegans can be inherited over several generations. This is probably achieved through the following epigenetic mechanism: inherited demethylated histones at some central loci, such as miRNA, transcription factors or signaling regulators affect the expression of certain genes leading to the longevity phenotype.
University of Southern California, Davis School of Gerontology, Los Angeles, CA, USA.
Shanshan
S
Pang
Sean P
SP
Curran
D000375:Aging; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D056426:Genetic Loci; D015894:Genome, Human; D005838:Genotype; D006657:Histones / Q000378:metabolism; D006801:Humans; D040582:Inheritance Patterns; D008136:Longevity; D010641:Phenotype; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D006657:Histones; D014157:Transcription Factors