Adult neural stem cells bridge their niche.
Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), with signaling pathways that control the behavior of NSCs. NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche.
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Luis C
LC
Fuentealba
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Kirsten
K
Obernier
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: abuylla@stemcell.ucsf.edu.
Arturo
A
Alvarez-Buylla
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology; D001921:Brain / Q000166:cytology*; D006801:Humans; D058953:Neural Stem Cells / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D015398:Signal Transduction; D055153:Stem Cell Niche