[Expression of mechano-growth factor and its roles in tissue repairs and regeneration].
OBJECTIVE
To review the expression of mechano-growth factor (MGF) and its roles in tissue repairs and regeneration.


METHODS
The literature about the expression of MGF and its roles in tissue repairs and regeneration in recent years was reviewed.


RESULTS
MGF is sensitive to mechanical stimulation and can be expressed in various tissues/cells. MGF is responsible for satellite cell activation, myoblast proliferation, and plays important roles in the treatment of muscle coloboma, prevention of myocardial injury, and neuroprotection.


CONCLUSIONS
The important role of MGF in tissue repairs and regeneration has been identified, however, the detailed mechanisms remain unclear up to now and still need a further study.
College of Bioengineering, Chongqing University, Chongqing 400044, PR China.
Bingyu
B
Zhang
Guanbin
G
Song
Qing
Q
Luo
Li
L
Yang
D017398:Alternative Splicing; D000818:Animals; D015870:Gene Expression; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D015398:Signal Transduction; D013314:Stress, Mechanical; D014945:Wound Healing
D018696:Neuroprotective Agents; D020033:Protein Isoforms; D007334:Insulin-Like Growth Factor I