The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury.
Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Roselló 149-153, 3rd Floor, Office 3.8, 08036 Barcelona, Spain.
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M
Elias-Miró
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MB
Jiménez-Castro
M
M
Mendes-Braz
A
A
Casillas-Ramírez
C
C
Peralta