[Polymorphisms of FEM1A gene in patients with polycystic ovary syndrome].
OBJECTIVE
To assess the association between FEM1A gene polymorphisms and polycystic ovary syndrome (PCOS) in Chinese Han patients.


METHODS
DNA sequencing was utilized to determine the genotypes of rs12460989 and rs8111933 loci of FEM1A gene in 120 PCOS patients and 155 healthy controls. Association between above polymorphisms and hyperandrogenism and insulin resistance (IR) was assessed.


RESULTS
Genotypes TT, TG and GG of the rs12460989 locus, and GG, GC and CC of the rs8111933 locus were detected. There were significant differences in allelic frequencies (Chi square= 33.302, P< 0.01; Chi square = 11.252, P<0.01, respectively) for above loci between the two groups. Multifactorial logistic regression analysis indicated that TG+GG genotype of rs12460989 and GC+CC genotype of rs8111933 were included into the main effect model of hyperandrogenism, and GC+CC genotype of rs8111933 was included into the main effect model of IR.


CONCLUSIONS
Particular genotypes of the rs12460989 and rs8111933 loci of FEM1A gene are associated with PCOS in Chinese Han and may be a potential risk factor of hyperandrogenism. Polymorphisms of the rs8111933 locus of FEM1A gene may be a risk factor of IR.
Department of Obstetrics and Gynecology, Fujian Medical University Teaching Hospital, Fujian Maternity and Child Health Hospital, Fuzhou, Fujian 350001, P. R. China. alice-96@163.com
Yuan
Y
Lin
Yan
Y
Sun
D000328:Adult; D044466:Asian People; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D017588:Hyperandrogenism / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics; D008969:Molecular Sequence Data; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011110:Polymorphism, Genetic
D018797:Cell Cycle Proteins; C444344:FEM1A protein, human