[The origin of elementary units of multicellularity and development of a spatial organization of cell layers].
The concept of the elementary unit of multicellularity, the histion, which also serves as a morphofunctional unit of cell layers, is introduced. Histions are cell groups formed as a result of division of labor between cells. Cell layers are regarded as regular cell networks (lattices) formed through polymerization of histions. The theory constructed based on this concept allows the composition and structure of a multitude of histions to be calculated; their development to be quantified; and families of topological and geometrical models for the histoarchitecture of cell layers to be constructed, visualized with computer programs, and experimentally verified. In addition, this model can predict previously unknown topological variants of the histoarchitecture of epithelial tissues, as well as their presence in normal development and pathology.
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Savost'ianov
D000818:Animals; D002477:Cells / Q000166:cytology* / Q000648:ultrastructure; D003198:Computer Simulation; D004848:Epithelium / Q000196:embryology / Q000648:ultrastructure; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis