Structure, biosynthesis, and properties of kurstakins, nonribosomal lipopeptides from Bacillus spp.
A new family of lipopeptides produced by Bacillus thuringiensis, the kurstakins, was discovered in 2000 and considered as a biomarker of this species. Kurstakins are lipoheptapeptides displaying antifungal activities against Stachybotrys charatum. Recently, the biosynthesis mechanism, the regulation of this biosynthesis and the potential new properties of kurstakins were described in the literature. In addition, kurstakins were also detected in other species belonging to Bacillus genus such as Bacillus cereus. This mini-review gathers all the information about these promising bioactive molecules.
Laboratoire des Procédés Biologiques, Génie Enzymatique et Microbien-ProBioGEM, UPRES-EA 1026, Polytech'Lille/IUT A, Université Lille Nord de France-Sciences et Technologies, USTL, 59655 Villeneuve d'Ascq Cedex, France.
Max
M
Béchet
Thibault
T
Caradec
Walaa
W
Hussein
Ahmed
A
Abderrahmani
Marlène
M
Chollet
Valérie
V
Leclère
Thomas
T
Dubois
Didier
D
Lereclus
Maude
M
Pupin
Philippe
P
Jacques
D000935:Antifungal Agents / Q000737:chemistry; D001409:Bacillus cereus / Q000378:metabolism; D001413:Bacillus thuringiensis / Q000378:metabolism*; D055666:Lipopeptides / Q000096:biosynthesis* / Q000737:chemistry*; D015394:Molecular Structure; D046908:Peptide Biosynthesis, Nucleic Acid-Independent; D011487:Protein Conformation
D000935:Antifungal Agents; D055666:Lipopeptides