Weight variation before and after surgery in Parkinson's disease: a noradrenergic modulation?
Changes in the nutritional profile of patients with Parkinson's disease have been reported before and after deep brain stimulation surgery. The major determinants of the weight variation in Parkinson's disease are not yet understood, and the mechanism seems complex. Based on the influence of the sympathetic nervous system in metabolic syndrome obesity, the intent of the present review is to consider the role of noradrenergic modulation on weight variations in Parkinson's disease. In this review the authors raise the following hypothesis: weight variation in Parkinson's disease before and after deep brain stimulation of the subthalamic nucleus could be influenced by noradrenergic interaction between the locus coeruleus, subthalamic nucleus, and hypothalamic nucleus.
Neurology Department, Faculty of Medicine, University of Porto, Hospital de São João, Porto, Portugal. joana.guimarães@med.up.pt
Joana
J
Guimarães
Eduardo
E
Moura
Maria Augusta
MA
Vieira-Coelho
Carolina
C
Garrett
D001835:Body Weight / Q000502:physiology; D046690:Deep Brain Stimulation; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D008125:Locus Coeruleus / Q000503:physiopathology; D009638:Norepinephrine / Q000502:physiology*; D010300:Parkinson Disease / Q000601:surgery*; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000601:surgery; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D015431:Weight Loss
D009638:Norepinephrine