Recent progress in interfacial tissue engineering approaches for osteochondral defects.
This review provides a brief synopsis of the anatomy and physiology of the osteochondral interface, scaffold-based and non-scaffold based approaches for engineering both tissues independently as well as recent developments in the manufacture of gradient constructs. Novel manufacturing techniques and nanotechnology will be discussed with potential application in osteochondral interfacial tissue engineering.
Department of Mechanical and Aerospace Engineering, Institute for Biomedical Engineering and Institute for Nanotechnology, The George Washington University, 726 Phillips Hall, 801 22nd Street NW, Washington, DC 20052, USA.
Nathan J
NJ
Castro
S Adam
SA
Hacking
Lijie Grace
LG
Zhang
D000818:Animals; D001847:Bone Diseases / Q000628:therapy*; D002357:Cartilage Diseases / Q000628:therapy*; D006801:Humans; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends