Analgesic effect of the electromagnetic resonant frequencies derived from the NMR spectrum of morphine.
Exposure to various types of electromagnetic fields (EMFs) affects pain specificity (nociception) and pain inhibition (analgesia). Previous study of ours has shown that exposure to the resonant spectra derived from biologically active substances' NMR may induce to live targets the same effects as the substances themselves. The purpose of this study is to investigate the potential analgesic effect of the resonant EMFs derived from the NMR spectrum of morphine. Twenty five Wistar rats were divided into five groups: control group; intraperitoneal administration of morphine 10 mg/kg body wt; exposure of rats to resonant EMFs of morphine; exposure of rats to randomly selected non resonant EMFs; and intraperitoneal administration of naloxone and simultaneous exposure of rats to the resonant EMFs of morphine. Tail Flick and Hot Plate tests were performed for estimation of the latency time. Results showed that rats exposed to NMR spectrum of morphine induced a significant increase in latency time at time points (p < 0.05), while exposure to the non resonant random EMFs exerted no effects. Additionally, naloxone administration inhibited the analgesic effects of the NMR spectrum of morphine. Our results indicate that exposure of rats to the resonant EMFs derived from the NMR spectrum of morphine may exert on animals similar analgesic effects to morphine itself.
Laboratory of Physiology, University of Ioannina, Ioannina, Greece. aevaggel@cc.uoi.gr
Ioannis I
II
Verginadis
Yannis V
YV
Simos
Anastasia P
AP
Velalopoulou
Athina N
AN
Vadalouca
Vicky P
VP
Kalfakakou
Spyridon Ch
SCh
Karkabounas
Angelos M
AM
Evangelou
D000698:Analgesia / Q000379:methods*; D000818:Animals; D001522:Behavior, Animal; D055909:Magnetic Field Therapy / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009020:Morphine / Q000737:chemistry*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar
D009020:Morphine