Improved protocol for indoline synthesis via palladium-catalyzed intramolecular C(sp2)-H amination.
An efficient method has been developed for the synthesis of indoline compounds from picolinamide (PA)-protected β-arylethylamine substrates via palladium-catalyzed intramolecular amination of ortho-C(sp(2))-H bonds. These reactions feature high efficiency, low catalyst loadings, mild operating conditions, and the use of inexpensive reagents.
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Gang
G
He
Chengxi
C
Lu
Yingsheng
Y
Zhao
William A
WA
Nack
Gong
G
Chen
D000586:Amination; D002384:Catalysis; D006860:Hydrogen Bonding; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D007211:Indoles; D010165:Palladium; C057812:indoline