[Neurobiology in borderline personality disorder].
Borderline personality disorder (BPD) is a severe psychiatric disorder characterised by instability of affect regulation, impulse control, interpersonal relationships, and self-image. The aim of this status article is to provide a brief overview of the neurobiological underpinnings of the core dimensions in BPD, as well as of the potential clinical implications. The latest results from genetic, endocrinologic, neuropsychologic, and neuroimaging research in identifying the dysfunctional neurobiological systems that could play a role in diathesis to BPD are presented.
Psykiatrisk Forskningsenhed, Region Sjælland, Toftebakken 9, 4000 Roskilde, Denmark. runan@regionsjaelland.dk
Rune
R
Andersen
Erik
E
Simonsen
D000342:Affective Symptoms / Q000503:physiopathology; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005625:Frontal Lobe / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D010641:Phenotype; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins