High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration.
BACKGROUND
The pathophysiology of pigment epithelial detachment (PED) secondary to age-related macular degeneration (AMD) is as yet incompletely understood and treatment remains challenging. Spectral domain optical coherence tomography (SD-OCT) allows for improved morphological characterisation of the space underneath the retinal pigment epithelium (RPE).


OBJECTIVE
To investigate eyes with PED for structures underneath the detached RPE cell layer.


METHODS
In a retrospective observational case study, SD-OCT scans of AMD-related PEDs were assessed for the presence of distinctive morphological features in the space between the detached RPE and inner Bruch's membrane.


RESULTS
Structures present in the space between the detached RPE and Bruch's membrane were found in 14 of 90 eyes with AMD-related PED. Each of these eyes shows hyper-reflective material underneath the PED, presenting as highly reflective, multilayered, laminar structures, usually orientated parallel to Bruch's membrane.


CONCLUSIONS
The findings indicate that SD-OCT may be useful for a more refined phenotypic stratification of AMD-associated PED. Further studies are warranted to explore the correlates on other imaging modalities, to investigate the composition of this material and to assess the potential prognostic relevance of this new finding.
Department of Ophthalmology, University of Muenster, Muenster, Germany.
Christoph R
CR
Clemens
Tim U
TU
Krohne
Peter
P
Charbel Issa
Hans-Martin
HM
Helb
Nina
N
Kosanetzky
Albrecht
A
Lommatzsch
Frank G
FG
Holz
Nicole
N
Eter
D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D016570:Bruch Membrane / Q000473:pathology; D022082:Cellular Structures / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D012163:Retinal Detachment / Q000175:diagnosis* / Q000209:etiology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A