Liver dysfunction in patients with early syphilis: a retrospective study.
Syphilis is one of the unrecognized etiologies of liver dysfunction. The incidence of syphilitic hepatitis is currently unknown. We conducted a retrospective study of causative agents of liver dysfunction at the time of diagnosis of early syphilis. Our study shows that 39 % (44/112) of early syphilis patients have liver enzyme abnormalities at the time of diagnosis and that 2.7 % (3/112) of patients are diagnosed with syphilitic hepatitis. Clinicians should include syphilitic hepatitis in the differential diagnosis for those patients with sexually transmitted diseases presenting with liver enzyme abnormalities.
Department of Infectious Diseases and Applied Immunology, Research Hospital of the Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Eisuke
E
Adachi
Tomohiko
T
Koibuchi
Michio
M
Okame
Hidenori
H
Sato
Tadashi
T
Kikuchi
Michiko
M
Koga
Hitomi
H
Nakamura
Aikichi
A
Iwamoto
Takeshi
T
Fujii
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D013587:Syphilis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D014210:Treponema pallidum / Q000276:immunology
D000907:Antibodies, Bacterial