Platelet adhesion and human umbilical vein endothelial cell cytocompatibility of biodegradable segmented polyurethanes prepared with 4,4'-methylene bis(cyclohexyl isocyanate), poly(caprolactone) diol and butanediol or dithioerythritol as chain extenders.
Biodegradable segmented polyurethanes were prepared with poly(caprolactone) diol as a soft segment, 4,4'-methylene bis(cyclohexyl isocyanate) (HMDI) and either butanediol or dithioerythritol as chain extenders. Platelet adhesion was similar in all segmented polyurethanes studied and not different from Tecoflex® although an early stage of activation was observed on biodegradable segmented polyurethane prepared with dithioerythritol. Relative viability was higher than 80% on human umbilical vein endothelial cells in contact with biodegradable segmented polyurethane extracts after 1, 2 and 7 days. Furthermore, both biodegradable segmented polyurethane materials supported human umbilical vein endothelial cell adhesion, spreading, and viability similar to Tecoflex® medical-grade polyurethane. These biodegradable segmented polyurethanes represent promising materials for cardiovascular applications.
Centro de Investigación Científica de Yucatán, A.C., Calle 43 # 130 Col. Chuburná de Hidalgo, Mérida, Yucatán, México.
L H
LH
Chan-Chan
R F
RF
Vargas-Coronado
J M
JM
Cervantes-Uc
J V
JV
Cauich-Rodríguez
R
R
Rath
E A
EA
Phelps
A J
AJ
García
J
J
San Román Del Barrio
J
J
Parra
Y
Y
Merhi
M
M
Tabrizian
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002072:Butylene Glycols / Q000737:chemistry / Q000378:metabolism; D003485:Cyanates / Q000737:chemistry / Q000378:metabolism; D004226:Dithioerythritol / Q000737:chemistry / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008422:Materials Testing; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism; D011140:Polyurethanes / Q000737:chemistry / Q000378:metabolism*; D014471:Umbilical Veins / Q000166:cytology* / Q000187:drug effects
D001672:Biocompatible Materials; D002072:Butylene Glycols; D003485:Cyanates; D011091:Polyesters; D011140:Polyurethanes; C016240:polycaprolactone; C013606:methylene bis(4-cyclohexylisocyanate); D004226:Dithioerythritol