[Pulmonary inflammation in cystic fibrosis].
Inflammation in Cystic Fibrosis is higher than bacterial clearance needs and contributes significantly to the deterioration of lung tissue and vital prognosis. Its physiology remains controversial and is more complex than the cycle infection-obstruction-inflammation previously described with many interactions and potentiating of the responsible different mechanisms (Mechanical factors, cells, protease/anti-protease, oxidative stress, leukotriens...). This perpetual inflammatory spiral is an important therapeutic target due to its crucial prognosis.
CHU de Bordeaux, Hôpital Pellegrin-Enfants, CRCM Pédiatrique (Centre de Ressource et de Compétence en Mucoviscidose), F-33076 Bordeaux, France. stephanie.bui@chu- bordeaux.fr
S
S
Bui
V
V
Boisserie-Lacroix
F
F
Ceccato
H
H
Clouzeau
S
S
Debeleix
M
M
Fayon
D002648:Child; D003550:Cystic Fibrosis / Q000150:complications* / Q000276:immunology*; D006801:Humans; D011014:Pneumonia / Q000209:etiology* / Q000276:immunology*