Direct substitution of hydroxy group of π-activated alcohols with electron-deficient amines using Re2O7 catalyst.
The first example of simple Re(2)O(7)-catalyzed direct dehydrative coupling between allylic alcohols with electron-deficient amines has been achieved under mild and open flask conditions. The protocol has also been successfully applied to benzylic and propargylic alcohols. The mechanistic proof for the S(N)1-type process has also been provided.
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal-462023, India.
Braja Gopal
BG
Das
Rajender
R
Nallagonda
Prasanta
P
Ghorai