Insulin-like growth factors in normal and diseased kidney.
This article reviews the physiology of the insulin-like growth factor (IGF) system in the kidney and the changes and potential role of this system in selected renal diseases. The potential therapeutic uses of recombinant human IGF-I for the treatment of acute and chronic kidney failure are briefly discussed.
Department of Pediatrics I, University Children's Hospital Heidelberg, INF 430, D-69120 Heidelberg, Germany. daniela.choukair@med.uni-heidelberg.de
Daniela
D
Kiepe
Burkhard
B
Tönshoff
D000818:Animals; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism*; D051379:Mice; D051381:Rats; D013002:Somatomedins / Q000502:physiology* / Q000627:therapeutic use*
D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins