Tumor suppression by p53: fall of the triumvirate?
p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.
The Beatson Institute for Cancer Research, Glasgow, UK.
Andreas K
AK
Hock
Karen H
KH
Vousden