Comparative antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing mouthrinse and a cetylpyridinium chloride-containing mouthrinse: A 6-month randomized clinical trial.
OBJECTIVE
This 6-month, examiner-blind, single-center, randomized, parallel group clinical trial compared the antiplaque and antigingivitis effects of an essential oil-containing mouthrinse with zinc chloride and sodium fluoride (EO) to a 0.05% cetylpyridinium chloride-containing mouthrinse (CPC) also with fluoride.


METHODS
Four hundred and eight gingivitis subjects were monitored for the primary outcomes of modified Gingival Index (MGI) and Plaque Index (PI) at baseline and 3 and 6 months. Subjects were randomly assigned to 6-month twice a day unsupervised use of EO, CPC, or negative control rinse in conjunction with normal brushing and flossing.


RESULTS
EO was always better than CPC at 3 and 6 months considering all parameters. All benefits allowed by EO increased from 3 to 6 months. CPC was better than the negative control at 3 and 6 months with respect to whole mouth plaque, and the proportion of more severe sites (baseline scores ≥ 3) in PI and MGI. At 6 months, CPC did not differ from negative control in relation to whole mouth MGI reduction, proximal MGI reduction, and percentages of sites improved over baseline in PI and MGI.


CONCLUSIONS
This new EO mouthrinse provided superior clinical benefits to CPC and demonstrated increasing plaque and gingivitis reductions over 6 months. Our findings support the regular long-term use of the EO mouthrinse and selection over a 0.05% CPC rinse for better efficacy.
Department of Periodontology, University of Taubaté, SP, Brazil. cavalcacortelli@uol.com.br
Sheila Cavalca
SC
Cortelli
José Roberto
JR
Cortelli
Mei-Miau
MM
Wu
Krista
K
Simmons
Christine Ann
CA
Charles
D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D002712:Chlorides / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D009822:Oils, Volatile / Q000627:therapeutic use*; D010512:Periodontal Index; D016037:Single-Blind Method; D012969:Sodium Fluoride / Q000627:therapeutic use; D017967:Zinc Compounds / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D002712:Chlorides; D009067:Mouthwashes; D009822:Oils, Volatile; D017967:Zinc Compounds; C016837:zinc chloride; D012969:Sodium Fluoride; D002594:Cetylpyridinium