The insulin-like growth factor system in cancer.
Insulin-like growth factor (IGF) plays an important role in tissue growth and development. Several studies have demonstrated the association between circulating levels of IGF-1 and -2 and cancer risk, and the IGF system has been implicated in the oncogenesis of essentially all solid and hematologic malignancies. The optimal strategy for targeting IGF signaling in patients with cancer is not clear. The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach.
Department of Oncology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA.
S John
SJ
Weroha
Paul
P
Haluska
D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D005260:Female; D005910:Glioma / Q000097:blood / Q000378:metabolism; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism; D009369:Neoplasms / Q000097:blood / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000097:blood / Q000378:metabolism; D011972:Receptor, Insulin / Q000502:physiology; D012306:Risk; D012509:Sarcoma / Q000097:blood / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D011972:Receptor, Insulin