A pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release.
Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires full-thickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.
Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, 00161 Rome, Italy.
Giovanni
G
Di Nardo
Salvatore
S
Oliva
Marina
M
Aloi
Federica
F
Ferrari
Simone
S
Frediani
Adriana
A
Marcheggiano
Salvatore
S
Cucchiara
D018798:Anemia, Iron-Deficiency / Q000150:complications; D001706:Biopsy; D002675:Child, Preschool; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D005748:Gastric Fundus / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000188:drug therapy*; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D008297:Male; D015282:Octreotide / Q000008:administration & dosage*; D013270:Stomach / Q000473:pathology; D016896:Treatment Outcome
D003692:Delayed-Action Preparations; D015282:Octreotide