7-oxygenated derivatives of dehydroepiandrosterone and obesity.
7-hydroxy/oxo derivatives of dehydroepiandrosterone are potential             regulators of the local cortisol activity due to their competition in the cortisolcortisone             balance mediated by 11ß-hydroxysteroid dehydrogenase. 7-hydroxy-dehydroepiandrosterone             is marketed as anti-obesity medication, though no             clinical study aimed at the benefit of administering 7-oxygenated derivatives of             dehydroepiandrosterone has appeared until now. We tried to show whether there             exist differences in levels of circulating 7-hydroxy/oxo-dehydroepiandrosterone             derivatives between lean and obese boys and girls. From a cohort of adolescents             investigated within the frame of anti-obesity programme 10 obese boys and             10 obese girls were compared with age-matched lean boys and girls in their             anthropometric data, and concentrations of both epimers of 7-hydroxy-dehydroepiandrosterone             and 7-oxo-dehydroepiandrosterone were determined by             the RIA method. The basal levels of 7α-hydroxy-dehydroepiandrosterone were             significantly higher in obese boys than in lean boys but not in girls. The association             was found for anthropometric parameters and 7α-hydroxy-dehydroepiandrosterone,             however again only in boys and not in girls. Higher levels of 7α-hydroxy-dehydroepiandrosterone             its positive association with anthropometric data in obese             boys may serve as a sign that, at least in boys, 7-oxygenated 5-ene-steroids may take             part in regulating the hormonal signal for fat formation or distribution.
Institute of Endocrinology, Prague, Czech Republic.
B
B
Sedláčková
L
L
Dušátková
H
H
Zamrazilová
P
P
Matucha
M
M
Bičíková
L
L
Stárka
D000293:Adolescent; D049628:Body Size; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*
C002914:7-oxodehydroepiandrosterone; D003687:Dehydroepiandrosterone