Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer.
The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p=0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p=0.0222), metastatic lymph node involvement (p=0.0018) and a higher clinical tumor stage (p=0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p=0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.
Institute of Pathology, Hannover Medical School, Germany.
Maximilian
M
Knoener
Till
T
Krech
Florian
F
Puls
Ulrich
U
Lehmann
Hans
H
Kreipe
Matthias
M
Christgen
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D051861:Kangai-1 Protein / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D011379:Prognosis; D040081:Protein Array Analysis / Q000379:methods; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
D014408:Biomarkers, Tumor; C497688:CD82 protein, human; D051861:Kangai-1 Protein