The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans.
INRA, UMR866 Dynamique Musculaire Et Métabolisme, 2 Place Viala, 34060 Montpellier, France. anthony.sanchez@univ-montp1.fr
Anthony M J
AM
Sanchez
Robin B
RB
Candau
Alfredo
A
Csibi
Allan F
AF
Pagano
Audrey
A
Raibon
Henri
H
Bernardi
D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000378:metabolism*
D055372:AMP-Activated Protein Kinases