[Treatment of metformin-associated lactate acidosis by haemodialysis].
Metformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two of the patients had normal kidney function previous to hospitalization. Treatment includes fluid replacement, IV sodium bicarbonate and haemodialysis.
Medicinsk Afdeling, Roskilde Sygehus, Køgevej 7-13, 4000 Roskilde, Denmark. karinschousboe@hotmail.com
Karin
K
Schousboe
Daniel
D
El Fassi
Erik Lilja
EL
Secher
Hanne
H
Elming
Knud
K
Rasmussen
Mads
M
Hornum
D000140:Acidosis, Lactic / Q000139:chemically induced / Q000628:therapy*; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D006435:Renal Dialysis / Q000379:methods
D007004:Hypoglycemic Agents; D008687:Metformin