[Diagnostic accuracy and linked evidence--testing the chain].
In this article we describe the methodological underpinnings in assessing the confidence in estimates of effects (quality of evidence) for diagnostic questions and resulting recommendations in guidelines. In particular, we will describe current considerations and research regarding the link between data relating to diagnostic accuracy and patient important outcomes and how to move from evidence about diagnostic tests and strategies to recommendations. Our deliberations and suggestions, a result of an invited presentation at the annual fall conference of the German Institute for Quality and Efficiency in Healthcare (IQWiG), are based on our work with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.
Department of Clinical Epidemiology & Biostatistics, WHO Collaborating Center for Evidence-informed Policy, Cochrane Applicability and Recommendations Methods Group, McMaster University Health Sciences Centre, Hamilton, ON, Canada. schuneh@mcmaster.ca
Holger J
HJ
Schünemann
Reem
R
Mustafa
Jan
J
Brozek
D015415:Biomarkers; D032921:Consensus; D003955:Diagnostic Tests, Routine; D019317:Evidence-Based Medicine; D005858:Germany; D006801:Humans; D009313:National Health Programs; D017063:Outcome Assessment, Health Care; D017410:Practice Guidelines as Topic; D011787:Quality of Health Care
D015415:Biomarkers