Rolling the dice to discover the role of DICER in tumorigenesis.
In an effort to identify the consequences of complete DICER1 loss in tumorigenesis, in this issue of Cancer Cell, Ravi et al. characterize the effects of homozygous deletion of Dicer1. Using an in vivo mouse model, they show that genetic deletion of Dicer1 does not preclude tumor formation.
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, 08908 Catalonia, Spain.
Veronica
V
Davalos
Manel
M
Esteller