Biomarkers intersect with the exposome.
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.
Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720-7356, USA. srappaport@berkeley.edu
Stephen M
SM
Rappaport
D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood; D004781:Environmental Exposure; D006801:Humans; D055442:Metabolome; D055432:Metabolomics; D009369:Neoplasms / Q000097:blood; D019636:Neurodegenerative Diseases / Q000097:blood; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome