Regulation of transforming growth factor-β1 activation and expression in the tissue remodeling involved in chronic rhinosinusitis.
Transforming growth factor-β1 (TGF-β1) plays a key role in the tissue remodeling processes involved in chronic rhinosinusitis (CRS), with the biological functions of secreted TGF-β1 regulated by multiple proteins. Among these regulators, latency-associated peptide and latent TGF-β-binding protein inhibit TGF-β1 function, whereas different proteases and integrins activate it. Progress in understanding the factors responsible for the bioactivity and expression of TGF-β1 has revealed that the dysregulation of TGF-β1 activation and expression is closely associated with the chronic respiratory inflammatory diseases involved in CRS. This review of the regulation of TGF-β1 activation and expression provides insight into the mechanism responsible for the different CRS subtypes, which will help further the investigation of novel therapy targets for the treatment of CRS.
Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei
W
Kou
Guo-Hua
GH
Hu
Hong-Bing
HB
Yao
Xiao-qiang
XQ
Wang
Yang
Y
Shen
Hong-Yong
HY
Kang
Su-Ling
SL
Hong
D002908:Chronic Disease; D006801:Humans; D012220:Rhinitis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*; D012852:Sinusitis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D053773:Transforming Growth Factor beta1 / Q000502:physiology*
D053773:Transforming Growth Factor beta1