[The effect of ionizing radiation with low dose rate on the state of electron transfer chain of enterocyte mitochondria of rat small intestine].
The influence of ionizing radiation with low absorbed dose rate (55 mGy x min(-1)) in 1, 12 and 24 hours after irradiation in doses of 0.1; 0.5 and 1.0 Gy on functional state of the electron transfer chain of the rat small intestine mitochondria was investigated by assessment of the oxygen consumption rate. The uncoupling of oxidation and phosphorylation, a decrease of phosphorylation rate and inhibition of ATP hydrolysis reactions were established in mitochondria in dependence on the irradiation dose and time interval after irradiation. The functional peculiarities of the oxidation-phosphorylation coupling sites of the mitochondrial electron transfer chain were detected.
L V
LV
Grubskaia
V M
VM
Voĭtsitskiĭ
S V
SV
Khizhniak
D019297:2,4-Dinitrophenol / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004579:Electron Transport / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D020895:Enterocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects*; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects*; D011839:Radiation, Ionizing; D051381:Rats; D014475:Uncoupling Agents / Q000494:pharmacology
D014475:Uncoupling Agents; D000255:Adenosine Triphosphate; D019297:2,4-Dinitrophenol