Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats.
OBJECTIVE
Stroke is a major cause of disability and death worldwide. Hypertension is one of the most important risk factors for stroke. The objective of this work was to study the synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats (SHR).


METHODS
Blood pressure was continuously monitored in conscious SHR. For acute study, a single dose of drugs was administrated via an intragastric catheter. For chronic study (4 months), drugs were delivered via rat chow.


RESULTS
A single dose of levamlodipine (from 1 mg/kg), bisoprolol (from 0.125 mg/kg), and their combinations significantly decreased blood pressure. The levamlodipine-induced tachycardia and the bisoprolol-induced bradycardia were temporized by the combination of these two drugs. Upon chronic treatment, this combination also decreased blood pressure variability and reduced organ damage.


CONCLUSIONS
Levamlodipine and bisoprolol produce synergic effects on blood pressure reduction and organ protection in SHR.
Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering & Research Center, China State Institute of Pharmaceutical Industry, Shanghai, China.
Yan-Ling
YL
Yang
Li-Ting
LT
Yu
Zhao-Tang
ZT
Wu
Jian-Guang
JG
Yu
Jing-Ming
JM
Zhang
Qing-Hua
QH
Chen
Yong-Chu
YC
Bao
Jian-Guo
JG
Liu
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D017298:Bisoprolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D009525:Niacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011336:Probability; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
D000959:Antihypertensive Agents; C542574:levamlodipine; D009525:Niacin; D017298:Bisoprolol