IgG4-related tubulointerstitial nephritis and lymphadenopathy after therapy for malignant lymphoma.
We report a middle-aged Japanese man who had a past history of malignant lymphoma with tubulointerstitial nephritis (TIN) presenting a high serum immunoglobulin G4 (IgG4) concentration and bilateral kidney enlargement and swelling of many lymph nodes. Although lymph node biopsy was not evident of a recurrence of lymphoma, kidney biopsy showed prominent infiltration of IgG4-positive plasma cells in a tubulointerstitial lesion but not in glomeruli. We made a diagnosis of IgG4-related TIN and lymphadenopathy; administration of oral prednisolone improved his physical and laboratory parameters. This is the first report of a case of IgG4-related TIN and lymphadenopathy after therapy for malignant lymphoma.
Department of Medicine, Division of Nephrology, Yokohama Rosai Hospital, Japan.
Yasuko
Y
Oshima
Ryosuke
R
Usui
Shun
S
Manabe
Naoki
N
Hasegawa
Yukio
Y
Kakuta
Kosaku
K
Nitta
Michiyasu
M
Hatano
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003110:Colonic Neoplasms / Q000150:complications / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008224:Lymphoma, Follicular / Q000150:complications / Q000628:therapy*; D008297:Male; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D011239:Prednisolone