High cut-off and high-flux membrane haemodialysis in a patient with rhabdomyolysis-associated acute kidney injury.
In a patient with rhabdomyolysis-associated anuric acute kidney injury, an 8-hour haemodialysis session was performed with a large-pore, high cut-off (HCO) membrane (in-vivo cutoff, 60 kDa). Subsequently, during another 8-hour dialysis session, a standard high-flux (HF) membrane (in-vivo cut-off, 15kDa) was used. Serum myoglobin levels were measured throughout both sessions. HCO haemodialysis reduced myoglobin serum levels by 50% within 4 hours (from 44946μg/L to 22315μg/L). In contrast, myoglobin serum levels increased from 21430μg/L to 34336μg/L during HF haemodialysis. Thus, HCO haemodialysis achieved a reduction in serum myoglobin level that is superior to any other renal replacement technique so far.
Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany. christian.albert@med.ovgu.de
Christian
C
Albert
Michael
M
Haase
Rinaldo
R
Bellomo
Peter R
PR
Mertens
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy*; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000295:instrumentation*; D012206:Rhabdomyolysis / Q000150:complications*
D008567:Membranes, Artificial