Tumour invasion: a new twist on Rac-driven mesenchymal migration.
Elongated mesenchymal migration of cancer cells is driven by Rac1 activation mediated by the adaptor NEDD9 and the exchange factor DOCK3. A new study reports a role for the transcription factor Twist1 in inducing mesenchymal migration by relieving the suppression of NEDD9 and DOCK3 by the microRNA let-7i.
Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, New Hunts House, Guy's Campus, King's College London, London SE1 1UL, UK. victoria.sanz_moreno@kcl.ac.uk
Victoria
V
Sanz-Moreno
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; C485840:DOCK3 protein, human; D020662:Guanine Nucleotide Exchange Factors; D035683:MicroRNAs; C099942:NEDD9 protein, human; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; C487931:mirnlet7 microRNA, human; D020830:rac1 GTP-Binding Protein