Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.
The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea.
So Jin
SJ
Lee
Myung Sook
MS
Huh
Seung Young
SY
Lee
Solki
S
Min
Seulki
S
Lee
Heebeom
H
Koo
Jun-Uk
JU
Chu
Kyung Eun
KE
Lee
Hyesung
H
Jeon
Yongseok
Y
Choi
Kuiwon
K
Choi
Youngro
Y
Byun
Seo Young
SY
Jeong
Kinam
K
Park
Kwangmeyung
K
Kim
Ick Chan
IC
Kwon
D000818:Animals; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D034741:RNA, Small Interfering; D013438:Sulfhydryl Compounds; D042461:Vascular Endothelial Growth Factor A; C118638:glycol-chitosan; D048271:Chitosan