Design, synthesis and anticancer activity of nitric oxide donating/chalcone hybrids.
A group of nitric oxide (NO) donating chalcone derivatives was prepared by binding amino chalcones with different NO-donating moieties including; nitrate esters, oximes and furoxans. Screening of the anticancer activity of the target compounds revealed that the selected NO-donating compounds exhibited from mild to strong cytotoxic activity. The NO/chalcone hybrids 3a and 3b exhibited remarkable activity against different types of cancer cell lines especially against the colon and melanoma cancer cell lines. The nitrate ester 3a exhibited moderate selectivity toward colon cancer subpanel with selectivity ratio of 5.87 at TGI level.
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
Mai A E
MA
Mourad
Mohamed
M
Abdel-Aziz
Gamal El-Din A A
Gel-D
Abuo-Rahma
Hassan H
HH
Farag
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002599:Chalcone / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry*; D014456:Ulcer / Q000139:chemically induced
D000970:Antineoplastic Agents; D009569:Nitric Oxide; D002599:Chalcone