[2-Methyl-3-phenylaminomethylquinolin-4-one as potential antidepressant with nootropic properties].
The new compound, 2-methyl-3-phenylaminomethylquinolin-4-on, belongs to V class of toxicity and exhibits antidepressant and antiamnesic properties. It is established that this compound reduces the duration of immobilization in the test of behavioral despair, prevents from the scopolamine induced amnesia, and exhibits antagonism with reserpine in mice. In a dose of 100 mg/kg, the synthesized compound influences the levels of cerebral catecholamines similarly to imipramine, but with a more pronounced decrease in the level of 5-hydroxytryptamine.
S Iu
SIu
Shtrygol'
V A
VA
Zubkov
I N
IN
Podol'skiĭ
I S
IS
Gritsenko
D042462:4-Quinolones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000647:Amnesia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007103:Immobilization / Q000379:methods; D008297:Male; D051379:Mice; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000494:pharmacology; D012601:Scopolamine / Q000009:adverse effects / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism
C573674:2-methyl-3-phenylaminomethylquinolin-4-one; D042462:4-Quinolones; D000928:Antidepressive Agents; D002395:Catecholamines; D018727:Muscarinic Antagonists; D012701:Serotonin; D012601:Scopolamine