Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair.
A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 μm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.
Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China. sujiacan2012@yahoo.cn
Jiacan
J
Su
Liehu
L
Cao
Baoqing
B
Yu
Shaojun
S
Song
Xinwei
X
Liu
Zhiwei
Z
Wang
Ming
M
Li
D000704:Analysis of Variance; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D005269:Femur / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D005898:Glass / Q000737:chemistry*; D006651:Histocytochemistry; D006801:Humans; D008422:Materials Testing; D009757:Nylons / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D011817:Rabbits; D054457:Tissue Scaffolds / Q000737:chemistry*
D018786:Bone Substitutes; D009757:Nylons