Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives.
BACKGROUND
Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro.


METHODS
The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recommendations of the Clinical and Laboratory Standards Institute.


RESULTS
Two compounds (P05 et P06) presented a good antibacterial effectiveness against two gram-positive bacteria. No antifungal potency was observed against the three Candida albicans strains used in the test.


CONCLUSIONS
Our results prove that the introduction of substituents on ketone function position 4 decreased the antimicrobial properties of the synthetized compounds.
Laboratoire Antibiotiques Antifongiques, Physico-Chimie, Synthèse et Activité Biologique, Département de Biologie, Faculté des Sciences, Tlemcen University, 13000 Tlemcen, Algeria. nagrah113@hotmail.com
N M
NM
Rahmoun
Z
Z
Boucherit-Otmani
K
K
Boucherit
M
M
Benabdallah
D
D
Villemin
N
N
Choukchou-Braham
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D052978:Disk Diffusion Antimicrobial Tests; D009285:Naphthoquinones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009285:Naphthoquinones; C005090:lawsone