Modeling brain disease in a dish: really?
Cellular programming and reprogramming technology (CPART) presents a novel approach for understanding disease progression and mechanism. In addition, CPART provides an innovative opportunity for developing diagnostic tools and novel drug candidates for therapy. In this Forum, we will discuss obstacles and solutions for modeling brain disease using CPART.
Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Maria C
MC
Marchetto
Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.
Fred H
FH
Gage
D000818:Animals; D001927:Brain Diseases / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D023822:Tissue Engineering