Neurocognitive alterations in hypertensive children and adolescents.
Hypertensive adults demonstrate performance deficits on neuropsychological testing compared with scores of normotensive controls. This article reviews emerging preliminary evidence that children with hypertension also manifest neurocognitive differences when compared with normotensive controls. Database and single-center studies suggest that children with hypertension manifest deficits on measures of neurocognition and have an increased prevalence of learning difficulties and that children with hypertension associated with obesity may be at increased risk for depression and anxiety. Studies suggesting blunted cerebrovascular reactivity in children with hypertension are also reviewed.
Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. marc_lande@urmc.rochester.edu
Marc B
MB
Lande
Juan C
JC
Kupferman
Heather R
HR
Adams
D000293:Adolescent; D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D009483:Neuropsychological Tests; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D000959:Antihypertensive Agents