Insulin-like growth factor-1 and central neurodegenerative diseases.
The previously undisputed neuroprotective role of insulin-like growth factor 1 (IGF-1) has been challenged by recent observations in IGF-1 receptor (IGF-1R) defective mutants. As new ligand-dependent and ligand-independent roles for IGF-1R are now emerging, new insights into the biologic role of brain IGF-1R and its connection with serum and brain IGF-1 function are urgently required. In the meantime, treatment of specific neurodegenerative diseases with IGF-1 may still be explored using adequate preclinical procedures.
Department of Functional and Systems Neuroscience, Cajal Institute, Avda Doctor Arce 37, Madrid 28002, Spain. torres@cajal.csic.es
Ignacio
I
Torres Aleman
D000375:Aging / Q000378:metabolism; D000818:Animals; D001343:Autophagy / Q000502:physiology; D002493:Central Nervous System Diseases / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D056811:Unfolded Protein Response / Q000502:physiology
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1