Genetic characteristics of one highly multi-drug-resistant strain of Klebsiella ozaenae.
One highly multi-drug-resistant, mucus-producing and foul-smelling strain of Klebsiella ozaenae was isolated from a patient in the ICU of a Chinese tertiary hospital. MICs of several clinical antimicrobials against the strain were obtained using the Vitek-2 Compact System with AST-GN13 cards and resistance genes were evaluated by PCR and gene sequencing. The strain was resistant to most of the β-lactams and quinolones tested and carried several antibiotic resistance genes, including bla(KPC-2), bla(TEM-98), bla(CTX-M-3), bla(SHV-26) and qnrS. To our knowledge, this is the first report of β-lactam and quinolone resistance genes co-existing in a K. ozaenae strain in China.
Department of Clinical Laboratory, Lishui Central Hospital, Zhejiang Province 323000, PR China.|Lab of Molecular Immunology & State Key Lab of Genetic Engineering, Institute of Biomedical Sciences, School of Life Science, Fudan University, Shanghai 200433, PR China.
Jiansheng
J
Huang
Lab of Molecular Immunology & State Key Lab of Genetic Engineering, Institute of Biomedical Sciences, School of Life Science, Fudan University, Shanghai 200433, PR China.
Xirong
X
Li
Lab of Molecular Immunology & State Key Lab of Genetic Engineering, Institute of Biomedical Sciences, School of Life Science, Fudan University, Shanghai 200433, PR China.
Naishuo
N
Zhu
Department of Clinical Laboratory, Lishui Central Hospital, Zhejiang Province 323000, PR China.
Guoxiong
G
Li
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007709:Klebsiella / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010641:Phenotype; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology; D017422:Sequence Analysis, DNA; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D047090:beta-Lactams