[Neuromediator systems of brain cortex and cerebellum under alcohol and morphine withdrawal syndrome conditions].
The content of key neuromidiators and some neuromediator amino acids in the brain cortex and cerebellum of rats has been investigated under conditions of alcohol and morphin withdrawal syndrome. By the end of the period of a 5-day forced intoxication, distinctions in the neurochemical effects of alcohol and morphin are manifested. At the maximum (1st day) of behavioural manifestations of withdrawal, similar changes of the state of katecholamine brain system are observed for both alcohol and morphin. By the end of one-week withdrawal (both alcohol and morphin) there is no full normalization of impaired neuromediator functions revealed at the earlier stages of withdrawal syndrome.
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Lelevich
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004298:Dopamine / Q000032:analysis / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism
D018377:Neurotransmitter Agents; D012701:Serotonin; D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D004298:Dopamine