Genomic characteristics of adhesion molecules in patients with symptomatic             pulmonary embolism.
The aim of this study was to identify the differences in the expression             of cell adhesion molecule-related mRNAs between symptomatic pulmonary embolism             (PE) and a control group, and to investigate the interactions among activated             leukocytes, platelets and endothelial cells. Whole human gene chip was applied             to detect the expression of cell adhesion molecule-related mRNAs in symptomatic             PE and in the control group, and statistical analysis was performed. In patients             with PE, the expression of the majority of integrin mRNAs located on leukocytes             and platelets was significantly upregulated. The expression of mRNAs related to             L-selectin and P-selectin glycoprotein ligand was significantly upregulated, while             the expression of mRNA related to E-selectin was significantly downregulated.             The expression of mRNAs related to classic cadherins and protocadherins was downregulated,             and the expression of mRNAs related to vascular endothelial cadherin was significantly             downregulated; the expression of mRNAs related to the immunoglobulin superfamily             had no obvious difference between the 2 groups. In conclusion, we demonstrated             that, in symptomatic PE patients, the adhesion of leukocytes and platelets was             enhanced; the activation of endothelial cells was obviously weakened; the adherens             junctions among endothelial cells were weakened, with the endothelium becoming             more permeable.
Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, PR China.
Yuan
Y
Xie
Qianglin
Q
Duan
Leming
L
Wang
Zhu
Z
Gong
Qiang
Q
Wang
Haoming
H
Song
Hao
H
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D019040:E-Selectin / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D015894:Genome, Human; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000378:metabolism; D016023:Integrins / Q000235:genetics / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D015854:Up-Regulation
D015820:Cadherins; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D007136:Immunoglobulins; D016023:Integrins; D012333:RNA, Messenger