Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases.
BACKGROUND
Interferon-alpha (IFN-α) therapy is used to treat hepatitis C infection. The exacerbation and occurrence of psoriasis in hepatitis C patients treated with IFN-α is increasingly recognized, but the distinct associated features, aetiology and management have not been reviewed.


OBJECTIVE
To review all published cases of hepatitis C patients who developed psoriasis while receiving IFN-α therapy.


METHODS
The review was conducted by searching the PubMed database using the keywords 'hepatitis C' AND 'psoriasis.' In addition, references to additional publications not indexed for PubMed were followed to obtain a complete record of published data.


RESULTS
We identified 32 publications describing 36 subjects who developed a psoriatic eruption while receiving IFN-α therapy for hepatitis C. Topical therapies were a commonly employed treatment modality, but led to resolution in only 30% of cases in which they were employed solely. Cessation of IFN-α therapy led to resolution in 93% of cases. Hundred per cent of those who developed psoriasis while on IFN-α therapy responded to systemic therapy and were able to continue the drug.


CONCLUSIONS
Further studies and analysis of IFN-α-induced lesions are necessary to clarify the role of IFN-α and the hepatitis C virus in the development of psoriatic lesions.
Division of Dermatology, Department of Medicine, University of California, San Diego, USA. maafshar@ucsd.edu
M
M
Afshar
A D
AD
Martinez
R L
RL
Gallo
T R
TR
Hata
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*
D000998:Antiviral Agents; D016898:Interferon-alpha