Primary dedifferentiated liposarcoma of the axilla arising in a mixed, well-differentiated and myxoid liposarcoma.
We describe a case of mixed liposarcoma of the axilla presenting as a high grade undifferentiated sarcoma with areas of well-differentiated and myxoid liposarcoma. MRI demonstrated a lobulated, septated intermuscular mass with marked heterogeneous gadolinium enhancement. A small focus of the tumor demonstrated fat suppressed signal more characteristic of well-differentiated liposarcoma. Pathologic analysis following wide local excision revealed a large, high grade sarcomatous component with highly pleomorphic cells with a thin rim of well-differentiated and myxoid liposarcoma on histologic examination. Dedifferentiated liposarcomas arising outside of the retroperitoneum are very rare, as are dedifferentiated liposarcomas arising from a histologically mixed liposarcoma. In this regard, this case illustrates an unusual combination of tumor location and histology which, to our knowledge, has not previously been reported.
Department of Radiology, University of Mississippi Medical Center, Jackson, MS, USA. gcampbell@umc.edu
Garth S
GS
Campbell
Thomas J
TJ
Lawrence
Scott E
SE
Porter
Luminita
L
Rezeanu
D001365:Axilla / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008080:Liposarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D018208:Liposarcoma, Myxoid / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012187:Retroperitoneal Space / Q000473:pathology