A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin.
The prognosis of patients with chronic respiratory tract infections, especially diffuse panbronchiolitis, is remarkably improved by long-term administration of low-dose macrolides. However, in some cases, patients are refractory to macrolide treatment and show a low or no response; therefore, new treatment strategies are required. Here we present a patient refractory to either single low-dose clarithromycin or azithromycin but responded remarkably to the combination usage of both macrolides.
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Yoshihiro
Y
Yamamoto
Koichi
K
Izumikawa
Naoki
N
Hosogaya
Yoshitomo
Y
Morinaga
Shigeki
S
Nakamura
Yoshifumi
Y
Imamura
Taiga
T
Miyazaki
Noriho
N
Sakamoto
Yuji
Y
Ishimatu
Hiroshi
H
Kakeya
Katsunori
K
Yanagihara
Akira
A
Yasuoka
Shigeru
S
Kohno
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017963:Azithromycin / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D017963:Azithromycin; D017291:Clarithromycin