The mitochondrial Ca(2+) uniporter.
Mitochondrial Ca(2+) uptake plays a fundamental role in the regulation of energy production and cell survival. Under physiological conditions, mitochondrial Ca(2+) uptake occurs by a uniport mechanism driven electrophoretically by the membrane potential created by the respiratory chain. The activity and the biochemical properties of the mitochondrial calcium uniporter (MCU) were extensively characterized for decades but the molecular identity of the channel has remained elusive. Here, we review the recent discovery of the mitochondria Ca(2+) uniporter that represents a groundbreaking result for the molecular understanding of mitochondrial Ca(2+) homeostasis and will provide insight into the role of mitochondrial Ca(2+) deregulation in the pathogenesis of human disorders.
Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G. Colombo 3, 35131 Padua, Italy.
Anna
A
Raffaello
Diego
D
De Stefani
Rosario
R
Rizzuto
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling; D020868:Gene Silencing; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism
D015220:Calcium Channels; C034703:mitochondrial calcium uniporter; D002118:Calcium