A systematic review: influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration.
BACKGROUND
Few studies in subjects over 50 yr of age have evaluated the influence of variable doses of vitamin D supplementation on serum 25-hydroxyvitamin D levels.


OBJECTIVE
We performed a meta-analysis of changes in circulating 25-hydroxyvitamin D level associated with vitamin D supplementation in Caucasian subjects over 50 yr old.


METHODS
We conducted a systematic search in literature databases and in references of past reviews.


METHODS
Randomized placebo or open-label trials that evaluated the influence of vitamin D supplementation on clinical outcomes were included in the study.


METHODS
We reviewed trial characteristics and serum 25-hydroxyvitamin D concentrations at baseline and during the trial.


RESULTS
Seventy-six trials published from 1984 to March 2011 included 6207 subjects allocated to 101 intervention groups that tested supplement doses ranging from 5 to 250 μg/d (median, 20 μg/d). For similar doses, trials could obtain increases in 25-hydroxyvitamin D three to four times lower than other trials. A meta-regression showed that in the absence of concomitant use of calcium supplements, the average increase in serum 25-hydroxyvitamin D concentrations was 0.78 ng/ml (1.95 nmol/liter) per microgram of vitamin D3 supplement per day. Compared to the vitamin D3, the vitamin D2 was associated with significantly lower increases (P = 0.03). Concomitant use of calcium supplementation and high 25-hydroxyvitamin D concentration at baseline was nonsignificantly associated with lower increases in 25-hydroxyvitamin D concentrations.


CONCLUSIONS
Dietary recommendations and randomized trials on vitamin D supplementation should evaluate whether increases in circulating 25-hydroxyvitamin D levels match expectations--for instance, the average increases obtained by trials on vitamin D3 without concomitant calcium supplements.
International Prevention Research Institute, Lyon, France. philippe.autier@i-pri.org
Philippe
P
Autier
Sara
S
Gandini
Patrick
P
Mullie
D000368:Aged; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood
D014807:Vitamin D; C104450:25-hydroxyvitamin D