Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.
The ChREBP transcription factor is regulated by glucose and plays a role in insulin sensitivity, but the mechanism underlying these effects remains unclear. In a recent Nature article, Herman et al. (2012) show that a shorter ChREBP isoform (ChREBP-β) links glucose transport to lipogenesis in white adipose tissue.
Inserm U1016, Institut Cochin, 75014 Paris, France.
Renaud
R
Dentin
Dominique
D
Langin
Catherine
C
Postic