Pentraxin 3 serum levels in children with atopic dermatitis.
PTX3 behaves as an acute-phase response protein as its blood levels rapidly and dramatically increase during endotoxic shock, sepsis, and other inflammatory and infectious conditions. Therefore, this study was designed to investigate a possible role of PTX3 in children with Atopic Dermatitis (AD). One-hundred-and-thirty-six patients (37 females, 99 males, mean age 10.4 years) were enrolled in the study. One hundred patients (74%) had only respiratory symptoms (allergic rhinitis and/or bronchial asthma); thirty-six patients (26%) showed dermatitis associated with respiratory allergy (allergic rhinitis and/or bronchial asthma). PTX3 levels were higher in children with AD and there was a significant correlation between serum PTX3 levels and SCORAD index (p-value=0.0001, rho=0.658). Therefore, this study may show that PTX3 might be a reliable marker for the severity of AD in children with respiratory allergy.
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy.
G L
GL
Marseglia
M
M
De Amici
A
A
Marseglia
S
S
Caimmi
M
M
Miraglia Del Giudice
M C
MC
Leoni
C
C
Salpietro
S
S
Leonardi
I
I
Brambilla
G
G
Ciprandi
D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D000683:Serum Amyloid P-Component / Q000032:analysis*; D000099153:Pentraxins
D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins