Sesquiterpenes from the roots of Illicium dunnianum.
Six allo-cedrane sesquiterpenes, four seco-prezizaane-type sesquiterpenes, two monocyclofarnesane sesquiterpenes, together with four known sesquiterpenes, were isolated from the roots of Illicium dunnianum. The structures were elucidated by spectroscopic methods including 1D and 2D NMR. The absolute configuration of 10 was determined by a CD experiment. Compounds 11 and 13 showed potent activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor in vitro, with IC₅₀ values of 2.10±0.40 and 1.93±0.57 μM, respectively. All compounds were evaluated for cytotoxicities against five human cancer cell lines (A549, Bel-7402, BGC-823, HCT-8, and A2780) in the MTT assay, but none of them exhibited activity at concentrations tested (10⁻⁵-10⁻⁷ M).
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Jian
J
Bai
Hui
H
Chen
Zhen-Feng
ZF
Fang
Shi-Shan
SS
Yu
Wen-Jie
WJ
Wang
Yang
Y
Liu
Shuang-Gang
SG
Ma
Yong
Y
Li
Jing
J
Qu
Song
S
Xu
Jun-Hong
JH
Liu
Fen
F
Zhao
Nan
N
Zhao
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000494:pharmacology; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010972:Platelet Activating Factor; D012717:Sesquiterpenes; D005966:Glucuronidase