[The advancement of cancer-associated fibroblasts in lung cancer].
Cancer-associated fibroblasts (CAFs) is fibroblast cells activated by cancer cells in tumor with myofibroblasts cells (MFs) properties. CAFs is the main components of the tumor microenvironment. Malignant conversion of CAFs phenotype is closely related to the tumor evolution. In this review, we summarized that: (1) The source of CAFs and morphology, and the relation between heterogenicity and the malignant phenotype conversion of CAFs with time-space change; (2) The current research status and question of clinical application on CAFs; (3) The relation of CAFs and invasion and metastasis of lung cancer; (4) CAFs in the prognosis and treatment of lung cancer.
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Cheng
C
Shen
Guowei
G
Che
D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis