Lhermitte-Duclos and Cowden diseases: breast cancer as an unusual initial presentation of these overlapping conditions.
The authors report the case of a woman presenting with breast cancer who subsequently developed neck pain and ataxia. She had a family history of breast cancer and Cowden disease. A MRI study of the brain revealed a lesion in the cerebellum consistent with Lhermitte-Duclos disease (LDD) and a lesion consistent with a meningioma in the temporal lobe. This case emphasises the importance of awareness of the overlap between LDD and Cowden disease.
Department of Surgery, St Vincent's University Hospital, Dublin, Ireland. siunwalsh@gmail.com
Siun
S
Walsh
Michael
M
Carter
Niall
N
Tubridy
Enda W
EW
McDermott
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D054643:INDEL Mutation; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D051059:PTEN Phosphohydrolase / Q000235:genetics; D013629:Tamoxifen / Q000627:therapeutic use
D000970:Antineoplastic Agents; D013629:Tamoxifen; D051059:PTEN Phosphohydrolase