Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up.
Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease usually having a good prognosis. But the recurrence of uveitis and the chronic progression of kidney injury are still main problems. We report a 15-year-old girl with TINU who showed proteinuria, pathological renal change, multiple organ dysfunction, and immune disorders. After 2 months of 1 mg/kg/day corticosteroid therapy, 24-h urine protein, liver function tests, and creatine kinase returned to normal level. In spite of this, steroid was tapered off slowly and small dose of steroid maintenance therapy lasted for 1 year. Her kidney and ocular symptoms did not recur during 5 years of follow-up. We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome.
Division of Nephrology, Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, Hunan, PR China.
Letian
L
Zhou
Ying
Y
Li
Fuyou
F
Liu
Youming
Y
Peng
Yinghong
Y
Liu
Jun
J
Li
D000293:Adolescent; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D009395:Nephritis, Interstitial / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy*
D005938:Glucocorticoids; D011241:Prednisone