Insulin-like growth factors in the peripheral nervous system.
Insulin-like growth factors (IGFs) play an integral role in development, growth, and survival. This article details the current understanding of the effects of IGFs in the peripheral nervous system (PNS) during health and disease, and introduces how the IGF system regulates PNS development and impacts growth and survival of PNS cells. Also discussed are implications of IGF signaling in neurodegeneration and the status and prospects of IGF therapies for PNS conditions. There is substantial support for the application of IGF therapies in the treatment of PNS injury and disease.
A. Alfred Taubman Medical Research Institute, University of Michigan, 109 Zina Pitcher Place, 4019 AAT-BSRB, Ann Arbor, MI 48109, USA.
Stacey A
SA
Sakowski
Eva L
EL
Feldman
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D002470:Cell Survival; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D008297:Male; D051379:Mice; D017933:Peripheral Nervous System / Q000254:growth & development / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D017451:Receptors, Somatomedin / Q000502:physiology; D013002:Somatomedins / Q000502:physiology* / Q000627:therapeutic use; D057170:Translational Research, Biomedical
D018969:Insulin-Like Growth Factor Binding Proteins; D017451:Receptors, Somatomedin; D013002:Somatomedins