Novel strategies to enhance survival and growth of pulp cells after dental restorations.
Using ex vivo human tooth, the authors demonstrated that dental pulp stromal cells that survive after placement of composite, mineral trioxide aggregate, and glass ionomer are weaker since they undergo synergistic cell death when exposed to 2-hydroxyethylmethacrylate. DPSCs extracted from teeth that were restored with the combination of composite or MTA or GI with N-acetyl cysteine were protectedfrom cell death. Therefore, application of NAC may protect the DPSCs from adverse effects after tooth restoration.
University of California, Los Angeles School of Dentistry, 90095, USA.
Dipak
D
Chaudhari
Eric C
EC
Sung
Avina
A
Paranjpe
Anahid
A
Jewett
D000111:Acetylcysteine / Q000494:pharmacology*; D017607:Aluminum Compounds / Q000494:pharmacology; D017610:Calcium Compounds / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003188:Composite Resins / Q000494:pharmacology; D003764:Dental Materials / Q000494:pharmacology*; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects*; D003793:Dental Restoration, Permanent; D004338:Drug Combinations; D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005899:Glass Ionomer Cements / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008689:Methacrylates / Q000494:pharmacology; D010087:Oxides / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology; D017640:Silicates / Q000494:pharmacology; D017154:Stromal Cells / Q000187:drug effects / Q000502:physiology
D017607:Aluminum Compounds; D017610:Calcium Compounds; D003188:Composite Resins; D003764:Dental Materials; D004338:Drug Combinations; D016166:Free Radical Scavengers; D005899:Glass Ionomer Cements; D008070:Lipopolysaccharides; D008689:Methacrylates; D010087:Oxides; D020011:Protective Agents; D017640:Silicates; C086631:mineral trioxide aggregate; C005044:hydroxyethyl methacrylate; D000111:Acetylcysteine