Cycloartane triterpenes and ingol diterpenes isolated from Euphorbia neriifolia in a screening program for death-receptor expression-enhancing activity.
In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O-tigloylingol (9), (24R)-cycloartane-3β,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Kazufumi
K
Toume
Takafumi
T
Nakazawa
Tahmina
T
Hoque
Takashi
T
Ohtsuki
Midori A
MA
Arai
Takashi
T
Koyano
Thaworn
T
Kowithayakorn
Masami
M
Ishibashi
D003110:Colonic Neoplasms / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004224:Diterpenes; D010936:Plant Extracts; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D014315:Triterpenes