An efficient synthesis of the 4'-epimer of 2-fluoronoraristeromycin.
The 4'-epimer of 2-fluoronoraristeromycin was synthesized by employing bis-t-butoxycarbonyl (Boc) protected 2-fluoroadenine as a superior substrate for the Mitsunobu reaction with the appropriate cyclopentenol. Unlike the unsubstituted counterpart 2-fluoroadenine, this substrate is completely soluble in THF and resulted in a very good yield in the Mitsunobu coupling reaction as well as subsequent steps.
Elizabeth City State University, Department of Chemistry, Geology, and Physics Elizabeth city, NC 27909.
Quachel
Q
Bazile
Tesfaye
T
Serbessa
Junyan
J
Zhong