Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals.
BACKGROUND
High serum resistin levels have been associated with kidney dysfunction. Most of these studies have been carried out in individuals with severe kidney impairment, diabetes, cardiovascular disease and related treatments. Thus, the observed association might have been influenced by these confounders. Our aim was to study the relationship between serum resistin, urinary albumin/creatinine ratio (ACR) and glomerular filtration rate (GFR) in a family-based sample, the Gargano Family Study (GFS) of 635 non diabetic, untreated Whites.


METHODS
A linear mixed effects model and bivariate analyses were used to evaluate the phenotypic and genetic relations between serum resistin and both ACR and eGFR. All analyses were adjusted for sex, age, age squared, BMI, systolic blood pressure, smoking habits and physical exercise.


RESULTS
After adjustments, resistin levels were slightly positively associated with ACR (β±SE = 0.049±0.023, p = 0.035) and inversely related to eGFR (β±SE = -1.43±0.61, p = 0.018) levels. These associations remained significant when either eGFR or ACR were, reciprocally, added as covariates. A genetic correlation (ρg = -0.31±0.12; adjusted p = 0.013) was observed between resistin and eGFR (but not ACR) levels.


CONCLUSIONS
Serum resistin levels are independently associated with ACR and eGFR in untreated non-diabetic individuals. Serum resistin and eGFR share also some common genetic background. Our data strongly suggest that resistin plays a role in modulating kidney function.
Research Unit of Diabetes and Endocrine Disease, IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, Italy. c.menzaghi@operapadrepio.it
Claudia
C
Menzaghi
Lucia
L
Salvemini
Grazia
G
Fini
Ryan
R
Thompson
Davide
D
Mangiacotti
Rosa
R
Di Paola
Eleonora
E
Morini
Maddalena
M
Giorelli
Concetta
C
De Bonis
Salvatore
S
De Cosmo
Alessandro
A
Doria
Vincenzo
V
Trischitta
D000367:Age Factors; D000419:Albuminuria / Q000652:urine; D001794:Blood Pressure; D015992:Body Mass Index; D003404:Creatinine / Q000652:urine; D015444:Exercise; D005190:Family; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016014:Linear Models; D052243:Resistin / Q000097:blood*; D012737:Sex Factors; D012907:Smoking; D044465:White People
D052243:Resistin; D003404:Creatinine