Stir bar sorptive extraction coupled to gas chromatography-mass spectrometry for the determination of bisphenols in canned beverages and filling liquids of canned vegetables.
This paper describes a method for the simultaneous determination of bisphenol A (BPA), bisphenol F (BPF), bisphenol Z (BPZ) and biphenol (BP), using stir bar sorptive extraction (SBSE) in combination with thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). Several parameters affecting both extraction and thermal desorption of the SBSE stages were carefully optimized by multivariate designs. SBSE was performed with two derivatization procedures, in situ acetylation and in tube silylation, and the results were compared with those obtained when the analytes were not derivatized. The proposed method, determining the analytes as acyl derivatives, was applied to analyze commercially canned beverages, as well as the filling liquids of canned vegetables, providing detection limits of between 4.7 and 12.5 ng L⁻¹, depending on the compound. The intraday and interday precisions were lower than 6% in terms of relative standard deviation. Recovery studies at two concentration levels, 0.1 and 1 μg L⁻¹, were performed providing recoveries in the 86-122% range. The samples analyzed contained higher concentrations of BPA than of the other analytes.
Department of Analytical Chemistry, Faculty of Chemistry, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, E-30071 Murcia, Spain.
J I
JI
Cacho
N
N
Campillo
P
P
Viñas
M
M
Hernández-Córdoba
D000089:Acetic Anhydrides / Q000737:chemistry; D001559:Benzhydryl Compounds / Q000032:analysis*; D001628:Beverages / Q000032:analysis*; D002254:Carbonates / Q000737:chemistry; D005591:Chemical Fractionation / Q000295:instrumentation / Q000379:methods*; D003510:Cyclohexanes / Q000032:analysis*; D057141:Food, Preserved / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D057230:Limit of Detection; D010636:Phenols / Q000032:analysis*; D015203:Reproducibility of Results; D012965:Sodium Chloride / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry; D000098704:Bisphenols; D000098826:Bisphenol A Compounds; D000098833:Bisphenol F Compounds
D000089:Acetic Anhydrides; D001559:Benzhydryl Compounds; D002254:Carbonates; D003510:Cyclohexanes; D010636:Phenols; D012965:Sodium Chloride; D014297:Trimethylsilyl Compounds; C031800:acetic anhydride; C005686:sodium carbonate; C047270:N,N-bis(trimethylsilyl)-2,2,2-trifluoroacetamide; C517113:bisphenol Z; D000098704:Bisphenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C008745:4,4'-bisphenol F; D000098833:Bisphenol F Compounds