Diagnostic and therapeutic challenges of hepatic sarcoidosis.
The authors report three cases of hepatic sarcoidosis complicated by portal hypertension in Caucasian patients. The cases varied in their presentations from normal liver function to symptomatic cholestasis and established liver cirrhosis. In one particular case the authors discovered hepatic sarcoid after a diagnostic gastroscopy for upper gastrointestinal (GI) bleeding which showed changes of portal hypertension. In all of these cases the authors gave our patients a prolonged course of immunosuppressive treatment with over all good long-term results. The authors hope that our work will provide a modern approach into treating this disease.
Gastroenterology Department, Cheltenham General Hospital, Cheltenham, Gloucestershire, UK. Dr.H.Mosea@doctors.org.uk
Haider
H
Mosea
James
J
Gotto
Zubair
Z
Khan
D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D005260:Female; D005773:Gastroscopy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine