Meta-analysis of association between particulate matter and stroke attack.
OBJECTIVE
We conducted systematic review as well as meta-analyses on the association between particulate matter and daily stroke attack from a number of epidemiologic studies.


METHODS
Twelve quantitative studies about the associations between particulate matter and stroke attack met the inclusive criteria. We evaluated the odds ratio (OR) of stroke attack associated with per 10 μg/m(3) increase of the concentration of PM(10) (particulate matter with aerodynamic diameter ≤ 10 μm) or PM(2.5) (particulate matter with aerodynamic diameter ≤ 2.5 μm) as effect scale, and a sensitivity analysis for the results was conducted.


RESULTS
In the time-series design, PM(10) exposure wasn't related to an increased risk of daily stroke attack [OR per 10 μg/m(3) = 1.002, 95% confidence interval (CI): 0.999~1.005], PM(2.5) exposure were related to an increased risk of daily stroke attack (OR per 10 μg/m(3) = 1.006, 95%CI: 1.002~1.010]; but in the case-crossover studies, PM(10) exposure was related to increase in risk of daily stroke attack (OR per 10 μg/m(3) = 1.028, 95%CI: 1.001~1.057). PM(2.5) exposure was not significant association with daily stroke attack (OR per 10 μg/m(3) = 1.016, 95%CI: 0.937~1.097). Sensitivity analysis showed that the results for PM(10) , PM(2.5) and daily stroke attack were robust in the time-series design.


CONCLUSIONS
We found some evidence for an effect of air pollutants on stroke attack risk.
Department of Public Health, Zhejiang University, Hangzhou, China.
Xiu-Yang
XY
Li
Xiao-Bo
XB
Yu
Wei-Wei
WW
Liang
Nan
N
Yu
Li
L
Wang
Xu-Jun
XJ
Ye
Kun
K
Chen
Ping-Da
PD
Bian
D018592:Cross-Over Studies; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D006801:Humans; D016017:Odds Ratio; D052638:Particulate Matter / Q000009:adverse effects*; D018570:Risk Assessment; D020521:Stroke / Q000139:chemically induced*; D013997:Time Factors
D052638:Particulate Matter