Finite element analysis of mechanics of lateral transmission of force in single muscle fiber.
Most of the myofibers in long muscles of vertebrates terminate within fascicles without reaching either end of the tendon, thus force generated in myofibers has to be transmitted laterally through the extracellular matrix (ECM) to adjacent fibers; which is defined as the lateral transmission of force in skeletal muscles. The goal of this study was to determine the mechanisms of lateral transmission of force between the myofiber and ECM. In this study, a 2D finite element model of single muscle fiber was developed to study the effects of mechanical properties of the endomysium and the tapered ends of myofiber on lateral transmission of force. Results showed that most of the force generated is transmitted near the end of the myofiber through shear to the endomysium, and the force transmitted to the end of the model increases with increased stiffness of ECM. This study also demonstrated that the tapered angle of the myofiber ends can reduce the stress concentration near the myofiber end while laterally transmitting force efficiently.
Sibley School of Mechanical and Aerospace Engineering, 220 Upson Hall, Cornell University, Ithaca, NY 14853, USA.
Chi
C
Zhang
Yingxin
Y
Gao
D000818:Animals; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D013314:Stress, Mechanical