Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production.
Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%.
Department of Life Science, Pohang University of Science and Technology , Pohang 790-784, Korea.
Jaoon Y H
JY
Kim
Jae Wook
JW
Lee
Woo Sirl
WS
Lee
Hyung-Ho
HH
Ha
Marc
M
Vendrell
Jacqueline T
JT
Bork
Youngsook
Y
Lee
Young-Tae
YT
Chang
D056804:Biofuels / Q000032:analysis / Q000382:microbiology; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
D056804:Biofuels; D054852:Small Molecule Libraries; D014227:Triazines