Immune recovery and T cell subset analysis during effective treatment with maraviroc.
OBJECTIVE
Patients treated with maraviroc frequently show high CD4+ T cell increases. The aim of this study was to detail the characteristics of maraviroc-induced immune recovery.


METHODS
We studied T cell subsets from frozen peripheral blood mononuclear cells of patients treated with raltegravir, etravirine and either maraviroc (REM, n = 24) or darunavir/ritonavir (RED, n = 17).


RESULTS
The two groups showed a similar decrease in activated CD4+ and CD8+ T cells. A greater loss of naive CD4+ T cells and a reduction in cells expressing CXCR4 were observed in REM patients, while RED patients showed a greater loss of cells expressing CCR5.


CONCLUSIONS
Our findings do not support a role for reduction in activated T cell subsets to explain the greater maraviroc-induced immune recovery. Reduction in CXCR4+CD4+ and higher expression of CCR5+CD4+ T cells might represent a potential protection from non-R5 tropic viral strain overgrowth.
Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy. cossarini.francesca@hsr.it
Francesca
F
Cossarini
Andrea
A
Galli
Laura
L
Galli
Alba
A
Bigoloni
Stefania
S
Salpietro
Concetta
C
Vinci
Liviana
L
Della Torre
Nicola
N
Gianotti
Vincenzo
V
Spagnuolo
Adriano
A
Lazzarin
Antonella
A
Castagna
Silvia
S
Nozza
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015704:CD4 Antigens / Q000032:analysis; D003510:Cyclohexanes / Q000008:administration & dosage*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D000077592:Maraviroc; D008875:Middle Aged; D019713:Receptors, CCR5 / Q000032:analysis; D019718:Receptors, CXCR4 / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*
D019380:Anti-HIV Agents; D015704:CD4 Antigens; C527276:CXCR4 protein, human; D003510:Cyclohexanes; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D014230:Triazoles; D000077592:Maraviroc