Enantioselective synthesis of 3,3'-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction.
An organocatalytic three-component reaction of isatins, malononitrile and isocyanoacetates provided 3,3'-dihydropyrryl-spirooxindoles in excellent yields and enantioselectivities. The products could be readily converted to valuable 3,3'-pyrrolidinyl-spirooxindoles.
Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wen-Tao
WT
Wei
Chun-Xia
CX
Chen
Rui-Jiong
RJ
Lu
Jin-Jia
JJ
Wang
Xue-Jing
XJ
Zhang
Ming
M
Yan
D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D006900:Hydroxylation; D007211:Indoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D000078183:Oxindoles; D011758:Pyrroles / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001688:Biological Products; D007211:Indoles; D000078183:Oxindoles; D011758:Pyrroles; D013141:Spiro Compounds; C022960:2-oxindole