Diastereodivergent de-epimerization in catalytic asymmetric allylic alkylation.
Diastereomers made to order: In an unprecedented ligand-controlled process a racemic mixture of four stereoisomers can be converted with high selectivity into each one of the diastereomers of the product, at will (see scheme). The mechanism of this deracemization of epimers, that is, a de-epimerization, was also studied.
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
Davide
D
Audisio
Marco
M
Luparia
Maria Teresa
MT
Oliveira
Dina
D
Klütt
Nuno
N
Maulide