Antioxidant and antitumor activities of the polysaccharide from seed cake of Camellia oleifera Abel.
To explore biomedical potential of the polysaccharide from seed cake of Camellia oleifera Abel, we investigated antioxidant and antitumor capacities of the polymer. The results showed that the polysaccharide is capable of scavenging both superoxide anion and hydroxyl radicals in vitro. The highest scavenging rate of superoxide anion and hydroxyl radicals is 85% and 76%, respectively. Using the model animal, Caenorhabditis elegans, we further show that the polysaccharide can increase antioxidant enzyme activity, decrease lipid peroxidation level, and reduce paraquat-induced oxidative damage at a polysaccharide concentration more than 50mg/l. We also revealed that the polysaccharide has some ferric chelating ability and strong in vivo antitumor activity. The antitumor rate against Sarcoma180 solid tumor grown in BALB/C mice reached 85.6% at the highest dose of 40 × 20 mg/kg days.
School of Sciences, Henan Agricultural University, Zhengzhou 450002, China. xchjin100@gmail.com
Xianchun
X
Jin
Yu
Y
Ning
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000201:enzymology; D028244:Camellia / Q000737:chemistry*; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D007502:Iron Chelating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D010269:Paraquat / Q000633:toxicity; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry
D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D007502:Iron Chelating Agents; D011134:Polysaccharides; D013481:Superoxides; D017665:Hydroxyl Radical; D010269:Paraquat