Inhibition of bacterial adhesion to live human cells: activity and cytotoxicity of synthetic mannosides.
Bacterial adhesion to glycosylated surfaces is a key issue in human health and disease. Inhibition of bacterial adhesion by suitable carbohydrates could lead to an anti-adhesion therapy as a novel approach against bacterial infections. A selection of five α-mannosides has been evaluated as inhibitors of bacterial adhesion to the polysaccharide mannan, as well as to the surface of live human HT-29 cells. Cell toxicity studies were performed to identify the therapeutic window for a potential in vivo-application of the tested carbohydrates. A previously published mannosidic squaric acid diamide was shown to be exceptionally effective as inhibitor of the bacterial lectin FimH.
Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Kiel, Germany.
Mirja
M
Hartmann
Heike
H
Papavlassopoulos
Vijayanand
V
Chandrasekaran
Carsten
C
Grabosch
Femke
F
Beiroth
Thisbe K
TK
Lindhorst
Claudia
C
Röhl
D001422:Bacterial Adhesion; D002448:Cell Adhesion; D002470:Cell Survival / Q000187:drug effects; D006031:Glycosylation; D019073:HT29 Cells; D006801:Humans; D008362:Mannosides / Q000494:pharmacology*
D008362:Mannosides