In-hospital mortality of intermittent vs daily antitubercular regimen in patients with meningeal tuberculosis--a retrospective study.
BACKGROUND
The Revised National Tuberculosis Control Programme (RNTCP), the State-run Tuberculosis Control Initiative of the Government of India, recommends intermittent thrice a week Directly Observed Treatment Short course (DOTS) both during intensive phase and continuation phase for a total of nine months for tubercular meningitis. However, most recent guidelines recommend daily regimen.


OBJECTIVE
Assessment of the in-hospital mortality in patients with meningeal tuberculosis.


METHODS
We retrospectively analyzed the data of patients (n = 98) admitted with a diagnosis of meningeal tuberculosis from January 1st 2006 to December 31st 2009 in a tertiary care centre in South India. Thwaites index score of four or less was used for diagnosis of meningeal tuberculosis which is a weighted diagnostic index score for dichotomised clinical variables including age, blood white cell count, duration of illness, CSF total white cell count, and CSF neutrophil percentage. We compared in-hospital treatment outcome of patients on thrice weekly intermittent DOTS regimen with daily regimen patients.


RESULTS
The inhospital mortality was same (27%) in the two treatment regimens (p 0.944). However, there was less incidence of hepatic dysfunction in the intermittent DOTS regimen, even though it was not statistically significant (p 0.148).


CONCLUSIONS
In the short-term, both regimens have similar mortality outcomes and no statistically significant difference in hepatic dysfunction during the hospital stay.
Pharmacy College, Medical College, Thiruvananthapuram. beenaiype@gmail.com
Thomas
T
Iype
Litta Elizabeth
LE
George
Ajith
A
Cherian
Aswini
A
Kumar
B K
BK
Ajitha
Sinchu
S
Chandy
K Vijaya
KV
Kumar
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D015897:Comorbidity; D023801:Directly Observed Therapy; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000401:mortality*
D000995:Antitubercular Agents