Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998-2008.
In this study, the presence of bisphenol A (BPA) in human placental and fetal liver samples collected from 1998 to 2008 was investigated to provide a more detailed analysis of the transfer of BPA across the placenta and fetal exposure to BPA. The average concentrations in placental samples were 12.6 ng g(-1) for free BPA, 17.2 ng g(-1) for BPA-glu, and 30.2 ng g(-1) for total BPA. The highest concentrations in placental samples were 165 ng g(-1) for free BPA, 178 ng g(-1) for BPA-glu, and 280 ng g(-1) for total BPA. Samples with higher levels of BPA-glu had higher levels of free BPA in general. Fetal age was observed to have a significant effect on BPA-glu levels in placental samples, but not on free or total BPA. The percentages of free BPA relative to total BPA for the placental samples varied considerably from 4.2% to 100%, suggesting that the ability of maternal liver and/or the placenta to conjugate BPA is highly variable during early to mid-gestation. The average concentrations in fetal liver samples were 9.02 ng g(-1) for free BPA, 19.1 ng g(-1) for BPA-glu, and 25.8 ng g(-1) for total BPA. The highest concentrations in fetal liver samples were 37.7 ng g(-1) for free BPA, 93.9 ng g(-1) for BPA-glu, and 123 ng g(-1) for total BPA. The percentages of free BPA level relative to total BPA for all fetal liver samples varied from 12.4% to 99.1%, indicating extensive variability in the ability of the human feto-placental unit to glucuronidate BPA.
Health Canada, Ottawa, Ontario, Canada K1A 0K9. xu-liang.cao@hc-sc.gc.ca
Xu-Liang
XL
Cao
Jie
J
Zhang
Cynthia G
CG
Goodyer
Stephen
S
Hayward
Gerard M
GM
Cooke
Ivan H A
IH
Curran
D001559:Benzhydryl Compounds; D004785:Environmental Pollutants / Q000032:analysis* / Q000493:pharmacokinetics; D005260:Female; D005333:Fetus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010636:Phenols / Q000032:analysis* / Q000493:pharmacokinetics; D010920:Placenta / Q000737:chemistry* / Q000378:metabolism; D011247:Pregnancy; D011792:Quebec; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds