Atypical patterns in portable monitoring for sleep apnoea: features of nocturnal epilepsy?
Atypical cardiorespiratory patterns can be found during routine clinical use of portable monitoring for diagnosis of sleep-disordered breathing (SDB). Over 1,000 consecutive portable recordings were analysed to study the potential ictal nature of stereotyped cardiorespiratory and motor patterns. Snoring, airflow, thoracic effort, pulse rate, body position, oxygen saturation and activity of the anterior tibialis muscles were quantified. Recordings showing stereotyped polygraphic patterns recurring throughout the night, but without the features of sleep apnoea (apnoea/hypopnoea index <5 events·h(-1)), were selected for investigation. Once included in the study, patients underwent attended nocturnal video polysomnography. A total of 15 recordings showing repeated polygraphic patterns characterised by a sequence of microphone activation, respiratory activity atypical for sleep and wakefulness, heart rate acceleration and limb movements, followed by body position change, were selected for investigation. Once included in the study, patients underwent attended nocturnal video polysomnography that showed frontal epileptic discharges triggering periodic electroencephalographic arousals, autonomic activation and stereotyped motor patterns. A diagnosis of nocturnal frontal lobe epilepsy (NFLE) was established for all patients. NFLE should be taken into consideration in patients with stereotyped and recurrent behavioural features during portable monitoring carried out for diagnosis of SDB.
Dept of Neurosciences, University of Parma, Via Gramsci 14, Parma, Italy. liborio.parrino@unipr.it
Liborio
L
Parrino
Giulia
G
Milioli
Andrea
A
Grassi
Fernando
F
De Paolis
Silvia
S
Riccardi
Elena
E
Colizzi
Marcello
M
Bosi
Mario Giovanni
MG
Terzano
D000328:Adult; D017034:Epilepsy, Frontal Lobe / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D009068:Movement; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000378:metabolism; D017286:Polysomnography / Q000379:methods; D012119:Respiration; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology; D012913:Snoring
D010100:Oxygen