Is NMDA receptor-coincidence detection required for learning and memory?
The Mg2+ block of NMDA-type glutamate receptors (NMDARs) is crucial to their function as synaptic coincidence detectors. An analysis of Drosophila expressing a Mg2+-independent NMDAR by in this issue of Neuron concludes that the Mg2+ block is required primarily for long-term memory.
Trinity College Institute for Neuroscience, Ireland. christopher.tabone@tcd.ie
Christopher J
CJ
Tabone
Mani
M
Ramaswami