Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney.
Dental amalgam is a source of exposure to elemental mercury vapor in the general population. The aim of this study was to elucidate the effect of elemental mercury vapor exposure from dental amalgam restorations on gene expression profiles. Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the cerebellum, increase the expression of 2 genes (Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
Department of Dental Material Science, School of Dentistry, Aichi Gakuin University, Aichi, Japan. yoshi@dpc.agu.ac.jp
Yoshifumi
Y
Takahashi
Shozo
S
Tsuruta
Akiko
A
Honda
Yasuyuki
Y
Fujiwara
Masahiko
M
Satoh
Akira
A
Yasutake
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D054022:Cerebrum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003723:Dental Amalgam / Q000009:adverse effects*; D005260:Female; D020869:Gene Expression Profiling; D050956:HSP40 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008628:Mercury / Q000009:adverse effects / Q000493:pharmacokinetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome / Q000187:drug effects*
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; C494643:Dnaja2 protein, rat; D050956:HSP40 Heat-Shock Proteins; D008565:Membrane Proteins; C486172:Tap1 protein, rat; D003723:Dental Amalgam; D000254:Sodium-Potassium-Exchanging ATPase; D008628:Mercury