Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression.
OBJECTIVE
Major depressive disorder (MDD) is an increasingly recognized risk factor of coronary artery disease (CAD). The aim of this study was to assess the relationship between renin-angiotensin system (RAS) genetic polymorphisms and CAD in a sample of depressed Iranian patients.


METHODS
A total of 191 patients with a history of unipolar depression were enrolled in a case/control study. The presence of MDD was reconfirmed at study entry using DSM-IV criteria and CAD was diagnosed by coronary angiography. Genotyping of six RAS genes polymorphisms was performed by a modified PCR-RFLP method.


RESULTS
DD genotype of ACE I/D was independently associated with the incidence of CAD in depressed patients (P=0.011, OR=9.41, 95% CI: 1.68-17.81). Moreover, serum creatinine (P=0.033, OR=11.91, 95%CI: 7.23-15.62) was an independent predictor of CAD among depressed individuals.


CONCLUSIONS
ACE I/D polymorphism may play a major role in the development of CAD amongst Iranian depressed patients.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Negar
N
Firouzabadi
Nader
N
Tajik
Ehsan
E
Bahramali
Hooman
H
Bakhshandeh
Soltan Ahmed
SA
Ebrahimi
Mohsen
M
Maadani
Maryam
M
Rasoulian
Tahereh
T
Mobasheri
Massoumeh
M
Shafiei
D000368:Aged; D054458:Amplified Fragment Length Polymorphism Analysis; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology / Q000235:genetics*; D003866:Depressive Disorder / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012084:Renin-Angiotensin System / Q000235:genetics; D012307:Risk Factors; D017422:Sequence Analysis, DNA
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A