Novel amphiphilic compounds effectively inactivate the vaccinia virus.
Recent studies demonstrated the ability of artificial ribonucleases (aRNases, small organic RNA cleaving compounds) to inactivate RNA-viruses via the synergetic effect of viral RNA cleavage and disruption of viral envelope [1,2]. Herein, we describe the antiviral activity of aRNases against DNA-containing vaccinia virus: screening of aRNases of various structures revealed that amphiphilic compounds built of positively charged 1,4-diazabicyclo[2.2.2] octane substituted at the bridge nitrogen atoms with aliphatic residues efficiently inactivate this virus. The first stage was the destruction of viral membrane and structure of surface proteins (electron microscopy data). Thus, 1,4-diazabicyclo[2.2.2] octane-based aRNases are novel universal agents inactivating both RNA- and DNA-containing viruses.
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. fedorova.antonia@gmail.com
A A
AA
Fedorova
E P
EP
Goncharova
E I
EI
Ryabchikova
V V
VV
Vlasov
M A
MA
Zenkova
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D057927:Hydrophobic and Hydrophilic Interactions; D012260:Ribonucleases / Q000378:metabolism; D013997:Time Factors; D014616:Vaccinia virus / Q000187:drug effects* / Q000502:physiology; D038301:Virus Inactivation / Q000187:drug effects*
D000998:Antiviral Agents; D012260:Ribonucleases