Huge pancreatic acinar cell carcinoma with high levels of AFP and fucosylated AFP (AFP-L3).
A 25-year-old Japanese woman with a large abdominal tumor (10 cm in diameter) and high level of serum alpha-fetoprotein (AFP, 1,222.4 ng/mL) was introduced and admitted to our hospital in January 2011. Pre-operative imaging modalities could not identify the tumor origin. There was no chronic hepatic viral disease, however, the elevated level of fucosylated AFP (87.8%) and connection with the left hepatic lobe led us to diagnose the tumor as a hepatocellular carcinoma. Surgical resection was performed in February. Histological findings revealed a pancreatic acinar cell carcinoma (ACC). Herein, we provide details of this difficulty to diagnose a case of ACC.
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan. hirage@m.ehime-u.ac.jp
Atsushi
A
Hiraoka
Hiromasa
H
Nakahara
Hideki
H
Kawasaki
Yuko
Y
Shimizu
Satoshi
S
Hidaka
Yusuke
Y
Imai
Hiroki
H
Utsunomiya
Haruka
H
Tatsukawa
Nayu
N
Tazuya
Hiroka
H
Yamago
Nobukazu
N
Yorimitsu
Tetsuya
T
Tanihira
Aki
A
Hasebe
Yasunao
Y
Miyamoto
Tomoyuki
T
Ninomiya
Masanori
M
Abe
Yoichi
Y
Hiasa
Bunzo
B
Matsuura
Morikazu
M
Onji
Kojiro
K
Michitaka
D000328:Adult; D018267:Carcinoma, Acinar Cell / Q000097:blood* / Q000175:diagnosis*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005643:Fucose / Q000737:chemistry; D006031:Glycosylation; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000737:chemistry / Q000378:metabolism*
C097353:AFP protein, human; D000509:alpha-Fetoproteins; D005643:Fucose