Target practice: modeling tumors with stem cells.
A variant neoplastic line of human pluripotent stem cell (hPSC) displays unique tumorigenic properties, including enhanced self-renewal and survival, and aberrant blockade in differentiation. Sachlos et al. adopted a neoplastic hPSC differentiation platform to screen small molecules that selectively induce differentiation of cancer stem cells.
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA.
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Sheng
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Ding