Wnt/β-catenin signaling and disease.
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands. h.clevers@hubrecht.eu
Hans
H
Clevers
Roel
R
Nusse
D000818:Animals; D004194:Disease / Q000235:genetics; D006801:Humans; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism*
D051153:Wnt Proteins; D051176:beta Catenin