Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
To investigate the role of alternative activation of macrophages, in particular, the role of the CD163/HO-1 axis in systemic juvenile idiopathic arthritis (s-JIA), we serially examined the concentrations of HO-1, sCD163 and pro-inflammatory cytokines (IL-10, IL-18, IL-6, neopterin, soluble TNF-α receptor types I and II) in patients with s-JIA complicated by macrophage activation syndrome (MAS/s-JIA). Serum concentrations of HO-1, sCD163 and IL-10 in s-JIA patients were markedly elevated in the active phase including MAS and correlated positively with indicators for s-JIA disease activity. Serum concentrations of HO-1, sCD163 and IL-10, as well as IL-18, remained elevated in s-JIA patients even in the inactive phase of disease, whereas clinical parameters and other pro-inflammatory cytokines normalized. These findings indicate that alternative macrophage activation plays an important role not only in the active phase but also in the inactive phase of s-JIA. These findings suggest that the inactive phase of s-JIA represents a state of compensated inflammation rather than absence of immune activity.
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-8641, Japan. shimizum@staff.kanazawa-u.ac.jp
Masaki
M
Shimizu
Akihiro
A
Yachie
D000293:Adolescent; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D001171:Arthritis, Juvenile / Q000097:blood* / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000097:blood* / Q000150:complications; D016753:Interleukin-10 / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008262:Macrophage Activation; D055501:Macrophage Activation Syndrome / Q000097:blood / Q000150:complications; D008264:Macrophages / Q000378:metabolism; D008297:Male; D019798:Neopterin / Q000097:blood; D011956:Receptors, Cell Surface / Q000097:blood*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D013997:Time Factors; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D020382:Interleukin-18; D015850:Interleukin-6; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D016753:Interleukin-10; D019798:Neopterin; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1