Unsuspected pulmonary embolism in patients with cancer.
BACKGROUND
The natural history of unsuspected pulmonary embolism (PE) in patients with cancer has not been thoroughly studied.


METHODS
We used the RIETE Registry data to compare the clinical characteristics, treatment strategies and outcome in cancer patients with unsuspected PE and in those presenting with symptomatic, acute PE.


RESULTS
Up to December 2011, 78 cancer patients with unsuspected PE and 1,994 with symptomatic PE had been enrolled. Patients with unsuspected PE more likely had colorectal cancer than those with symptomatic PE (28% vs. 13%), and less likely had prostate (3.8% vs. 10%) or hematologic (1.3% vs. 6.4%) cancer, or prior venous thromboembolism (3.8% vs. 12%). While the patients were receiving anticoagulant therapy, the incidence of PE recurrences (0% vs. 1.9%) or major bleeding (2.6% vs. 4.8%) were similar. After completion of anticoagulation, recurrent PE developed in 2.6% vs. 1.4% of patients, and major bleeding in 0% vs. 0.4%, respectively.


CONCLUSIONS
Our findings suggest that the clinical characteristics and outcome in cancer patients with unsuspected PE are quite similar to those in patients with symptomatic PE.
Department of Internal Medicine, Hospital Sant Jaume, Olot, Gerona, Spain.
Silvia
S
Soler
Cristina
C
Delgado
Aitor
A
Ballaz
Elena
E
Cisneros
Radován
R
Malý
Dimitrios
D
Babalis
Manuel
M
Monréal
D000925:Anticoagulants / Q000627:therapeutic use*; D015897:Comorbidity; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D011655:Pulmonary Embolism / Q000188:drug therapy* / Q000453:epidemiology*; D012042:Registries / Q000706:statistics & numerical data*; D018570:Risk Assessment; D016896:Treatment Outcome
D000925:Anticoagulants