The Gly460Trp polymorphism of alpha-adducin gene as a predictor of renal function decline over 4 years of follow-up in an apparently healthy Chinese population.
There were conflict data between alpha-adducin Gly460Trp genetic variant and changes of renal function. We conducted a prospective study to investigate the influence of alph-adducin Gly460Trp polymorphism on the quantitative changes of renal function. Of 1500 people screened, 112 non-diabetic normotensive elderly Chinese were recruited and received biochemistry examination at the baseline, at the second and fourth year follow-up. Serum creatinine and calculated renal parameter, using Modification of Diet in Renal Disease (MDRD) Study, were used to evaluate renal function and their progression. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Age was 71.9 ± 3.7 years (range 60-81). Serum creatinine and MDRD glomerular filtration rate (GFR) were significantly worsened at the 2 and 4-year follow-up (all P < 0.001). The magnitude of 4-year decline of MDRD GFR was significantly higher in subjects carrying the a-adducin Gly460Trp G-allele than TT genotype (P = 0.045). The multivariate analyses showed that a-adducin Gly460Trp (P = 0.034), baseline MDRD GFR (P < 0.001), diastolic blood pressure (P = 0.021) and body weight (P = 0.022) could independently predict 4-year change of MDRD GFR. This longitudinal study showed that the aging process was associated with decline of renal function in the healthy elderly. The alpha-adducin Gly460Trp gene polymorphism might modulate these changes in the Chinese. This provides further knowledge essential in the assessment of renal disease and determination of renal function in the older subjects.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Department of Internal Medicine, Faculty of Medicine, Kaohsiung, Taiwan.
Tsung-Hsien
TH
Lin
Herng-Chia
HC
Chiu
Chiao-Ling
CL
Wang
Po-Chao
PC
Hsu
Ho-Ming
HM
Su
Wen-Chol
WC
Voon
Wen-Ter
WT
Lai
Sheng-Hsiung
SH
Sheu
D000375:Aging / Q000235:genetics; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D058070:Asymptomatic Diseases; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000208:ethnology / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D000099291:Adducins