[Expression of TMEM16A in gastric carcinoma and its clinical implications].
OBJECTIVE
To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications.


METHODS
A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.


RESULTS
TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).


CONCLUSIONS
Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.
Department of Pathology, Second Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, China. yangjundr@yahoo.com.cn
Jun
J
Yang
Ni
N
Liu
Anjing
A
Kang
Yaofeng
Y
Jin
Junning
J
Wang
Baoshan
B
Su
Xiaoli
X
Chen
Zongfang
Z
Li
D000328:Adult; D000368:Aged; D000075369:Anoctamin-1; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D018118:Chloride Channels / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
C476213:ANO1 protein, human; D000075369:Anoctamin-1; D018118:Chloride Channels; D009363:Neoplasm Proteins