[Expression and clinical significance of calcium-binding protein S100A9 in breast cancer].
OBJECTIVE
To investigate the  expression and clinical significance of calcium-binding protein S100A9 in the patients of breast cancer.


METHODS
The serum S100A9 level from 39 cases of preoperative breast cancer,  15 postoperative patients,  and 10 healthy women was detected by ELISA. Immunohistochemistry was used to detect the S100A9 expression in 12  specimens of  breast cancer tissues.


RESULTS
The serum S100A9 level  was significantly higher   in  the preoperative breast cancer patients  than that in the healthy women (P<0.01) and   the postoperative breast cancer patients(P<0.01). The serum S100A9 level of the breast cancer patients with lymph node metastasis was significantly higher than those without lymph node metastasis (P<0.01). S100A9 level in the serum was related to patient age,  tumour size, histological grade,  and pathological  type (P<0.01). The expression of S100A9 protein in breast cancer tissues was significantly higher than that in   paracancerous benign breast tissues.


CONCLUSIONS
The expression of S100A9  significantly increases in the serum and tissues of patients with breast cancer, which indicates  that S100A9 may function as a marker of diagnosis and treatment effect in breast cancer.
Department of Pathology, Capital Medical University, Beijing, China. duxm212@yeah.net
Xue-mei
XM
Du
Hong
H
Chang
Huan-ying
HY
Sun
Jian-ying
JY
Zhang
Ying
Y
Gao
Bing
B
Shen
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D040502:Calgranulin B / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading
D014408:Biomarkers, Tumor; D040502:Calgranulin B