Association of chronic plaque psoriasis and severe periodontitis: a hospital based case-control study.
BACKGROUND
Both chronic plaque psoriasis and periodontitis have an increasing prevalence worldwide and have been associated with the metabolic syndrome; however limited information is available on their association.


OBJECTIVE
To evaluate the possible association of severe periodontitis and chronic plaque psoriasis.


METHODS
This was a hospital based case-control study. Chronic plaque psoriasis patients and age- and gender-matched controls have been recruited. Baseline demographic data have been recorded. To explore correlations between different dichotomous variables the Sperman Rho correlation coefficient was used. Correlations were further explored non-parametrically and univariate and multivariate logistic regression was utilized after adjustment for the effect of confounders.


RESULTS
During the study enrollment period 100 patients with CPP and 100 age- and gender-matched controls were included in this study. Mean age for both groups was 57.2 ± 5.3 years. 43% of patients and controls were males. Significant correlations where noted between psoriasis and 1) periodontitis (rho = 0.219, P = 0.02) and 2) metabolic syndrome (rho = 0.191, P = 0.07) using Spearman's Rho correlation co-efficient. Univariate logistic regression reported significant relations between psoriasis and periodontitis (OR = 3.329, 95%CI: 1.513-7.324, P = 0.003) and psoriasis and metabolic syndrome (OR = 2.293, 95%CI: 1.250-4.207, P = 0.007). On the contrary, a non-significant relation between psoriasis and active smoking status was detected (OR = 1.041, 95%CI: 0.597-1.817, P = 0.887). In a multivariate analysis model we found a significant correlation of psoriasis and periodontitis when controlled for the presence of metabolic syndrome (OR: 2.486, 95%CI: 1.002-5.842, P = 0.049).


CONCLUSIONS
Periodontitis may be associated with psoriasis but further studies are required to elucidate their relationship in the context of the biologic plausibility.
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece. bethlaz@med.auth.gr
E
E
Lazaridou
A
A
Tsikrikoni
C
C
Fotiadou
E
E
Kyrmanidou
E
E
Vakirlis
C
C
Giannopoulou
Z
Z
Apalla
D
D
Ioannides
D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications*; D011565:Psoriasis / Q000150:complications*; D012720:Severity of Illness Index