Two new chlorophenyl glycosides from the bulbs of Lilium brownii var. viridulum.
Two rare new chlorophenyl glycosides, 2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (1) and 4-chlorol-5-hydroxyl-3-methyl-phenol 1-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2), along with three known compounds (3-5) were isolated from the bulbs of Lilium brownii var. viridulum. The structures of the new compounds were elucidated on the basis of spectroscopic and chemical methods. All the compounds exhibited weak inhibition of NO production in LPS-stimulated RAW 264.7 cells.
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Xiao-Xiao
XX
Hong
Jian-Guang
JG
Luo
Ling-Yi
LY
Kong
D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification*; D027762:Lilium / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry
C576113:2,4,6-trichlorol-3-methyl-5-methoxy-phenol 1-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranoside; C576114:4-chlorol-5-hydroxyl-3-methyl-phenol 1-O-alpha-L-rhamnopyranosyl-(1-6)-beta-D-glucopyranoside; D006027:Glycosides; D006843:Hydrocarbons, Chlorinated; D008070:Lipopolysaccharides; D009569:Nitric Oxide