Life-threatening retro-pharyngeal bleed in a case of systemic lupus erythematosus--an uncommon but important evil of a common disease.
Acquired inhibitors of coagulation are antibodies that interfere with the coagulation system either by functional inhibition of the activity of clotting factors or by their increased clearance from the plasma. They can be idiopathic or seen in various physiologic (pregnancy and postpartum) or pathologic states (systemic lupus erythematosus (SLE), malignancies, rheumatoid arthritis) and can result in a variety of haemorrhagic sequelae. SLE can be associated with antibodies to multiple clotting factors and bleeding though rare can be an important haematologic manifestation with life-threatening consequences in these patients.
Department of Internal Medicine, Danbury Hospital, Danbury, Connecticut, United States. Amruth.Palla@wcthealthnetwork.org
Amruth
A
Palla
John
J
Rogers
Sindhu
S
Singh
D000906:Antibodies / Q000097:blood; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology*; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006470:Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology*; D010608:Pharyngeal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011994:Recombinant Proteins / Q000627:therapeutic use; D000069283:Rituximab; D013256:Steroids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000906:Antibodies; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D011994:Recombinant Proteins; D013256:Steroids; D000069283:Rituximab; D005169:Factor VIII; C103587:recombinant FVIIa; D015942:Factor VIIa