Simvastatin-loaded macroporous calcium phosphate cement: preparation, in vitro characterization, and evaluation of in vivo performance.
The aim of our study was to construct macroporous calcium phosphate bone cements (CPCs) with enhanced osteogenic potential. For this purpose, 300 mM sodium dodecyl sulfate (SDS) as an air-entraining agent was added to the liquid phase and 1, 5, and 10% simvastatin (SIM) was homogenized with the solid phase. The physical and mechanical characteristics of the test samples were investigated. Biological properties of the new CPCs were examined after intramuscular and endosteal implantation in rabbits. The introduction of SDS produced interconnected macropores and did not significantly affect initial setting time, transformation of solid phase to hydroxyapatite, and biocompatibility of CPCs. Large amounts (10 wt %) of SIM could decrease the compressive strength and induce severe muscular necrosis and inflammatory reaction. Small amounts (1 wt %) of SIM were compatible with the CPCs did not affect the physico-chemical properties or biocompatibility and were sufficient to enhance the osteogenic potential of macroporous CPCs.
Department of Orthopaedics, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong, China.
Han
H
Yin
Yong-Gang
YG
Li
Meng
M
Si
Jian-Min
JM
Li
D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D001842:Bone and Bones / Q000293:injuries / Q000648:ultrastructure; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008422:Materials Testing; D010012:Osteogenesis; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D019821:Simvastatin / Q000008:administration & dosage*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D014961:X-Ray Diffraction
D001843:Bone Cements; D002130:Calcium Phosphates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D012967:Sodium Dodecyl Sulfate; C020243:calcium phosphate; D019821:Simvastatin