Polarizing macrophages through reprogramming of glucose metabolism.
Reprogramming of intracellular metabolism is common in activated immune cells. In this issue of Cell Metabolism, Haschemi et al. (2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.
Goodman Cancer Research Centre, Department of Physiology, McGill University, Montreal, QC, Canada, H3G 1Y6.
Julianna
J
Blagih
Russell G
RG
Jones