Hybrid isoprenoids from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64.
Indotertine A (1), a hybrid isoprenoid with a condensed pentacyclic skeleton, together with two related hybrid isoprenoids, drimentines F (2) and G (3), were isolated from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. Their structures including absolute configurations were elucidated by spectroscopic methods, X-ray single crystal diffraction analysis, and TDDFT ECD calculations. Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC(50)'s down to 1.01 μM, while 1 and 2 showed no significant activity.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Qian
Q
Che
Tianjiao
T
Zhu
Xin
X
Qi
Attila
A
Mándi
Tibor
T
Kurtán
Xiaomei
X
Mo
Jing
J
Li
Qianqun
Q
Gu
Dehai
D
Li
D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry* / Q000378:metabolism; D011789:Quantum Theory; D058441:Rhizosphere; D012989:Soil Pollutants / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism
D012989:Soil Pollutants; D013729:Terpenes