Hypercalcaemia from genitourinary tuberculosis in a female with multiple exostoses.
The authors present a puzzling case of nephrolithiasis, hypercalcaemia, amenorrhoea, short stature and gross skeletal deformities in a 30-year-old female. Multiple pituitary hormone deficiency and metabolic bone disease were initially considered but were eventually excluded. The final diagnosis is genitourinary tuberculosis (TB) which caused the hypercalcaemia, nephrolithiasis and amenorrhoea, and also found to have the syndrome of multiple exostoses which explained the gross skeletal deformities and the short stature. After treatment with anti-TB therapy, there was resolution of hypercalcaemia and return of regular menstruation. The short stature and gross skeletal deformities remain as part of the congenital syndrome.
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Joselynna
J
Anel-Quimpo
Mark Anthony Santiago
MA
Sandoval
Frances Lina
FL
Lantion-Ang
D000328:Adult; D000568:Amenorrhea / Q000382:microbiology*; D003937:Diagnosis, Differential; D005097:Exostoses, Multiple Hereditary / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000382:microbiology*; D053040:Nephrolithiasis / Q000175:diagnosis / Q000209:etiology*; D014384:Tuberculosis, Female Genital / Q000150:complications / Q000175:diagnosis*