Photon-manipulated drug release from a mesoporous nanocontainer controlled by azobenzene-modified nucleic acid.
Herein a photon-manipulated mesoporous release system was constructed based on azobenzene-modified nucleic acids. In this system, the azobenzene-incorporated DNA double strands were immobilized at the pore mouth of mesoporous silica nanoparticles. The photoisomerization of azobenzene induced dehybridization/hybridization switch of complementary DNA, causing uncapping/capping of pore gates of mesoporous silica. This nanoplatform permits holding of guest molecules within the nanopores under visible light but releases them when light wavelength turns to the UV range. These DNA/mesoporous silica hybrid nanostructures were exploited as carriers for the cancer cell chemotherapy drug doxorubicin (DOX) due to its stimuli-responsive property as well as good biocompatibility via MTT assay. It is found that the drug release behavior is light-wavelength-sensitive. Switching of the light from visible to the UV range uncapped the pores, causing the release of DOX from the mesoporous silica nanospheres and an obvious cytotoxic effect on cancer cells. We envision that this photocontrolled drug release system could find potential applications in cancer therapy.
Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Biology, and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Quan
Q
Yuan
Yunfei
Y
Zhang
Tao
T
Chen
Danqing
D
Lu
Zilong
Z
Zhao
Xiaobing
X
Zhang
Zhenxing
Z
Li
Chun-Hua
CH
Yan
Weihong
W
Tan
D000970:Antineoplastic Agents / Q000008:administration & dosage; D001391:Azo Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D036103:Nanotechnology; D055668:Photochemical Processes; D017785:Photons; D012822:Silicon Dioxide
D000970:Antineoplastic Agents; D001391:Azo Compounds; D003692:Delayed-Action Preparations; D012822:Silicon Dioxide; D004317:Doxorubicin; D004247:DNA; C009850:azobenzene