Serum (1->3)-β-D-glucan measurement in coccidioidomycosis.
The serum (1→3)-β-d-glucan assay has emerged as an important diagnostic test for invasive fungal disease. The utility of this assay in coccidioidomycosis has not been previously studied. Using a cutoff value of ≥80 pg/ml, we found the sensitivity (43.9%), specificity (91.1%), positive predictive value (81.8%), and negative predictive value (64.1%) to be similar to those of the assay in diagnosing other invasive mycoses.
Department of Medical Microbiology and Immunology, Coccidioidomycosis Serology Laboratory, University of California-Davis, Davis, California, USA. grthompson@ucdavis.edu
George R
GR
Thompson
Derek J
DJ
Bays
Suzanne M
SM
Johnson
Stuart H
SH
Cohen
Demosthenes
D
Pappagianis
Malcolm A
MA
Finkelman
D003047:Coccidioidomycosis / Q000175:diagnosis*; D006801:Humans; D011237:Predictive Value of Tests; D011509:Proteoglycans; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry*; D047071:beta-Glucans / Q000097:blood*
D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K