Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.
Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-?. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.
Section of Genetics, Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Sun-Don
SD
Kim
Jia Lie
JL
Liu
Tony
T
Roscioli
Michael F
MF
Buckley
Garima
G
Yagnik
Simeon A
SA
Boyadjiev
Jinoh
J
Kim
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D008969:Molecular Sequence Data; D010740:Phospholipases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000502:physiology*; D020449:Repetitive Sequences, Amino Acid; D015398:Signal Transduction
D017931:DNA Primers; D007136:Immunoglobulins; D011494:Protein Kinases; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1; D010740:Phospholipases; D007930:Leucine