Nuclear GPS for interchromosomal clustering.
Nuclear architecture and the relative position of a gene can play roles in the regulation of its expression. In this issue of Developmental Cell, Brickner et al. (2012) analyze nuclear global positioning of genes and reveal that the Put3 transcription factor functions with cis-encoded DNA elements and nuclear pore complexes to regulate interchromosomal gene clustering.
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Laura T
LT
Burns
Susan R
SR
Wente