Translational neuroprotection research in glaucoma: a review of definitions and principles.
The maintenance of vision, through prevention and attenuation of neuronal injury in glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular pressure is the only proven method to achieve these goals. Although this strategy enjoys considerable success, some patients progress to blindness; hence, additional management options are highly desirable. Several terms describing treatment modalities of neuronal diseases with potential applicability to glaucoma are used in the literature, including neuroprotection, neurorecovery, neurorescue and neuroregeneration. These phenomena have not been defined within a coherent framework. Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic.
South Australian Institute of Ophthalmology, Hanson Institute and Adelaide University, Adelaide, South Australia, Australia. robert.casson@adelaide.edu.au
Robert J
RJ
Casson
Glyn
G
Chidlow
Andreas
A
Ebneter
John P M
JP
Wood
Jonathan
J
Crowston
Ivan
I
Goldberg
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005901:Glaucoma / Q000145:classification / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009901:Optic Nerve Diseases / Q000188:drug therapy*; D009626:Terminology as Topic; D057170:Translational Research, Biomedical
D000959:Antihypertensive Agents; D018696:Neuroprotective Agents