Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides.
Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc(2)O and MgCl(2).
Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
Hongyu
H
Yin
Chenglong
C
Zhao
Hengzhi
H
You
Kunhua
K
Lin
Hegui
H
Gong
D000812:Anhydrides / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000812:Anhydrides; D006846:Hydrocarbons, Halogenated; D007659:Ketones; D009532:Nickel