The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: a randomized clinical trial in obese Mexican women.
BACKGROUND
Obesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women.


METHODS
In a randomized controlled clinical trial 144 women (18-50 y) with BMI ≥ 25 kg/m², were allocated into one of the following treatments during 3 months: 1) Two doses/d of a partial meal replacement (PMR), 2) Two doses/d of PMR with inulin (PMR + I) , 3) Two doses/d of 5 g of inulin (INU) and 4) Control group (CON). All groups received a low calorie diet (LCD). Weight, height, hip and waist circumference were measured every 2 weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3 months.


RESULTS
All groups significantly reduced weight, BMI, waist and hip circumference. Differences between groups were only observed in BMI and weight adjusted changes: At 45 days PMR group lost more weight than INU and CON groups by 0.9 and 1.2Kg, respectively. At 60 days, PMR + I and PMR groups lost more weight than in INU by 0.7 and 1Kg, respectively. Subjects in PMR, PMR + I and INU significantly decreased triglycerides. Energy intake was reduced in all groups. Fiber intake increased in PMR + I and INU groups. Some minerals and vitamins intakes were higher in PMR and PMR + I compared with INU and CON groups.


CONCLUSIONS
Inclusion of PMR with and without inulin to a LCD had no additional effect on weight reduction than a LCD alone but reduced triglycerides and improved intake of micronutrients during caloric restriction. PMR could be a good alternative for obese populations with micronutrient deficiencies.
School of Natural Sciences, University of Queretaro, Queretaro, Mexico.
Alma Rosa
AR
Tovar
María del Carmen
Mdel C
Caamaño
Sandra
S
Garcia-Padilla
Olga Patricia
OP
García
Miguel Angel
MA
Duarte
Jorge L
JL
Rosado
D000293:Adolescent; D000328:Adult; D000601:Amino Acids, Essential / Q000008:administration & dosage / Q000172:deficiency / Q000627:therapeutic use; D015992:Body Mass Index; D003906:Developing Countries; D004038:Diet, Reducing / Q000009:adverse effects / Q000379:methods*; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology / Q000517:prevention & control*; D007444:Inulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008800:Mexico; D018977:Micronutrients / Q000008:administration & dosage* / Q000172:deficiency / Q000627:therapeutic use; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D050177:Overweight / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D010352:Patient Dropouts; D015431:Weight Loss; D055815:Young Adult
D000601:Amino Acids, Essential; D018977:Micronutrients; D007444:Inulin