Chemo- and regioselective direct hydroxylation of arenes with hydrogen peroxide catalyzed by a divanadium-substituted phosphotungstate.
Peroxide in, phenol out: The catalyst [γ-PW(10)O(38)V(2)(μ-OH)(2)](3-) showed high activity in the hydroxylation of various aromatic compounds with aqueous H(2)O(2). The system was regioselective, producing para-phenols from monosubstituted benzene derivatives. Furthermore, alkylarenes with reactive side-chain C sp 3-H bonds could be chemoselectively hydroxylated without significant formation of side-chain oxygenated products.
Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 , Japan.
Keigo
K
Kamata
Taiyo
T
Yamaura
Noritaka
N
Mizuno
D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006900:Hydroxylation; D010636:Phenols / Q000737:chemistry*; D010772:Phosphotungstic Acid / Q000737:chemistry*; D013237:Stereoisomerism; D017968:Vanadium Compounds / Q000737:chemistry*
D001555:Benzene Derivatives; D010636:Phenols; D017968:Vanadium Compounds; D010772:Phosphotungstic Acid; D006861:Hydrogen Peroxide