Renal function after preeclampsia: a longitudinal pilot study.
BACKGROUND
Women with a history of preeclampsia are at increased risk to develop end-stage renal disease. In this longitudinal study, we evaluated renal function in women with a history of severe preeclampsia and parous controls over a period of 14 years.


METHODS
Renal function was measured 1 and then 14 years postpartum by para-aminohippurate and inulin clearances in 20 women with a history of severe preeclampsia and 8 parous controls.


RESULTS
The difference in glomerular filtration rate 1 year postpartum between women with a history of preeclampsia and parous controls (112 ± 10 and 125 ± 8 ml/min/1.73 m(2), p < 0.01) had disappeared 14 years postpartum (104 ± 10 and 109 ± 13 ml/min/1.73 m(2), p = 0.37). There was a consistent trend for a lower effective renal plasma flow both 1 and 14 years postpartum (477 ± 90 and 543 ± 92, p = 0.09 and 473 ± 85 and 543 ± 98 ml/min/1.73 m(2), p = 0.07).


CONCLUSIONS
This explorative study suggests no accelerated renal function loss in the first decade after preeclampsia.
Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands. julia.spaan@maastrichtuniversity.nl
Julia J
JJ
Spaan
Timo
T
Ekhart
Marc E A
ME
Spaanderman
Louis L H
LL
Peeters
D000328:Adult; D000704:Analysis of Variance; D062186:Arterial Pressure; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D008137:Longitudinal Studies; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D017596:Renal Plasma Flow, Effective; D018709:Statistics, Nonparametric; D013997:Time Factors; D014655:Vascular Resistance