Voltage-dependent K+ channels as oncotargets in malignant gliomas.
Because both imipramine and citalopram have been commonly used to treat depression, which commonly occurs in glioma patients, it would be interesting to conduct large epidemiological studies to investigate the actual benefit that these two drugs would provide for malignant glioma patients when delivered during their glioma treatment. Such large-scale epidemiological studies have recently revealed the actual benefit provided by digoxin, a Na+/K+ ATPase inhibitor used to treat heart failure, in prostate cancer patients treated for both prostate cancer and heart failure.
Florence
F
Lefranc
Henri-Benjamin
HB
Pouleau
Michal
M
Rynkowski
Olivier
O
De Witte
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects; D015283:Citalopram / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance / Q000187:drug effects; D005910:Glioma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology* / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors*
D000928:Antidepressive Agents; D024642:Potassium Channels, Voltage-Gated; D015283:Citalopram; D007099:Imipramine