Using a quartz crystal microbalance biosensor for the study of metastasis markers on intact cells.
The use of biosensors has become a standard method to characterize biomolecular interactions. Data obtained from biosensor studies are widely used to evaluate drug candidates, particularly in relation to their binding properties towards a selected target. The importance of measuring such interactions in a biologically relevant environment has become the new challenge for the biosensor technologies. In this chapter we describe a method for studying interactions between proteins and targets at the surface of intact cells using a quartz crystal microbalance (QCM) biosensor.
R&D Department, DHR Finland Oy, Innotrac Diagnostics, Turku, Finland.
Julien
J
Saint-Guirons
Björn
B
Ingemarsson
D014408:Biomarkers, Tumor / Q000378:metabolism*; D015374:Biosensing Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D006801:Humans; D009362:Neoplasm Metastasis; D011485:Protein Binding; D058525:Quartz Crystal Microbalance Techniques / Q000379:methods*
D014408:Biomarkers, Tumor