The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers: an experimental and clinical study.
The purpose of this prospective experimental and clinical study is to evaluate the effectiveness of the intralesional injection of platelet-rich plasma (PRP), in the management of non-healing chronic wounds. Skin defects were created in the ears of 20 white New Zealand rabbits. In the study group, autologous PRP was injected intralesionally. The control group was treated conservatively. Nineteen out of 20 cases of the study group healed within a mean time of 24·9 days. In the control group, seven defects healed within a mean period of 26·7 days, seven ulcers did not heal at day 28 and in six cases a full thickness ear defect was recorded. For a 3-year period, 26 patients with chronic ulcers underwent surgical debridement and intralesional injection of PRP. A histological study was performed before and 7 days after PRP injection. Ten patients healed within a mean period of 7 weeks. In 16 cases, PRP prepared the wound bed for the final and simpler reconstructive procedure. Intralesional injection is a newly described method for application of PRP and represents an effective therapeutic option when dealing with non-healing wounds.
Department of Plastic Surgery, Aristotle University Thessaloniki, Thessaloniki, Greece. ddionyssiou@gmail.com
Dimitrios
D
Dionyssiou
Efterpi
E
Demiri
Pericles
P
Foroglou
Aggeliki
A
Cheva
Nikolaos
N
Saratzis
Constantine
C
Aivazidis
George
G
Karkavelas
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001707:Biopsy, Needle; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D016523:Foot Ulcer / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D015552:Injections, Intralesional; D007871:Leg Ulcer / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D011817:Rabbits; D012720:Severity of Illness Index; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D055815:Young Adult