[Role of actin microfilaments in depression of acetylcholine-induced current in Helix lucorum neurons on cellular analogue of habituation].
Toxins that impair the function of actin microfilaments in cytoskeleton, cytochalasin B (disrupts microfilaments by inhibiting actin polymerization) and phalloidin (binds polymeric F-actin, stabilizing it and interfering with the function of actin-rich structures) reduce the depression of acetylcholine-induced inward current in Helix lucorum command neurons of defensive behavior during rhythmical local acetylcholine applications to soma (cellular analogue of habituation). These results and mathematical simulation allow us to suggest that the depression of cholinosensitivity of extrasynaptic membrane zones in command neurons on the cellular analogue of habituation is associated with the involvement of actin microfilaments in reduction of the number of membrane cholinoreceptors.
A S
AS
Pivovarov
N A
NA
Vasil'eva
G B
GB
Murzina
D A
DA
Makhnovskiĭ
D000109:Acetylcholine / Q000378:metabolism* / Q000494:pharmacology; D000199:Actins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D003198:Computer Simulation; D003571:Cytochalasin B / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism; D006185:Habituation, Psychophysiologic; D006372:Helix, Snails; D036881:Long-Term Synaptic Depression / Q000187:drug effects*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*; D010590:Phalloidine / Q000494:pharmacology
D000199:Actins; D010590:Phalloidine; D003571:Cytochalasin B; D000109:Acetylcholine