New phenolic compounds from Dendrobium capillipes and Dendrobium secundum.
Phytochemical investigation of the stem of Dendrobium capillipes resulted in the isolation of a new flavonol glycoside namely quercetin-3-O-α-L-rhamnopyranosyl-(1 → 2)-β-d-xylopyranoside, along with seven known phenolic compounds which included two flavonol glycosides and five bibenzyls. From the stem of Dendrobium secundum, a new compound named 5-hydroxy-3,4,3',4',5'-pentamethoxybibenzyl was characterized, together with two known bibenzyls and three glycosidic flavonoids. Some of the isolated bibenzyls showed cytotoxicity against KB, NCI-H187, and MCF-7 cancer cells, whereas all of the glycosidic flavonoids were devoid of activity.
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Thanawuth
T
Phechrmeekha
Boonchoo
B
Sritularak
Kittisak
K
Likhitwitayawuid
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031667:Dendrobium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D006027:Glycosides; D010636:Phenols; D011794:Quercetin