Hematopoietic stem cell heterogeneity takes center stage.
Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, V5Z 1L3 BC, Canada.
Michael R
MR
Copley
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, V5Z 1L3 BC, Canada.
Philip A
PA
Beer
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, V5Z 1L3 BC, Canada. Electronic address: ceaves@bccrc.ca.
Connie J
CJ
Eaves
D000818:Animals; D002454:Cell Differentiation; D002999:Clone Cells / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*