[Treatment resistant depression: therapy and novel neuromodulatory treatments].
Unipolar depression is among the leading cause of invalidity and disability-adjusted life-years. Many depressed patients do not respond to several antidepressant treatments. Several treatments have been investigated in resistant depression using electrical or magnetic stimulation of the brain. In this field, electroconvulsivotherapy remains to date the only treatment validated for efficacy and security. Novel neuromodulatory treatments used in neurological conditions are currently under investigation. Vagus nerve stimulation and deep brain stimulation may offer long-term efficacy and therefore justify expensive and highly specialized treatment programs.
Programme Bipolaire, Service de psychiatrie générale, HUG, 1207 Genève. markus.kosel@hcuge.ch
Markus
M
Kosel
Alexandre
A
Berney
D000928:Antidepressive Agents / Q000627:therapeutic use; D046690:Deep Brain Stimulation / Q000379:methods / Q000706:statistics & numerical data; D061218:Depressive Disorder, Treatment-Resistant / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods / Q000639:trends; D006801:Humans; D018377:Neurotransmitter Agents / Q000627:therapeutic use; D035703:Therapies, Investigational / Q000379:methods* / Q000639:trends; D055536:Vagus Nerve Stimulation / Q000379:methods / Q000706:statistics & numerical data
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents