euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling.
The loss of cardiac pump function accounts for a significant increase in both mortality and morbidity in Western society, where there is currently a one in four lifetime risk, and costs associated with acute and long-term hospital treatments are accelerating. The significance of cardiac disease has motivated the application of state-of-the-art clinical imaging techniques and functional signal analysis to aid diagnosis and clinical planning. Measurements of cardiac function currently provide high-resolution datasets for characterizing cardiac patients. However, the clinical practice of using population-based metrics derived from separate image or signal-based datasets often indicates contradictory treatments plans owing to inter-individual variability in pathophysiology. To address this issue, the goal of our work, demonstrated in this study through four specific clinical applications, is to integrate multiple types of functional data into a consistent framework using multi-scale computational modelling.
Imaging Sciences and Biomedical Engineering Division ,  St Thomas' Hospital, King's College London ,  London ,  UK.
Nic
N
Smith
Adelaide
A
de Vecchi
Matthew
M
McCormick
David
D
Nordsletten
Oscar
O
Camara
Alejandro F
AF
Frangi
Hervé
H
Delingette
Maxime
M
Sermesant
Jatin
J
Relan
Nicholas
N
Ayache
Martin W
MW
Krueger
Walther H W
WH
Schulze
Rod
R
Hose
Israel
I
Valverde
Philipp
P
Beerbaum
Cristina
C
Staicu
Maria
M
Siebes
Jos
J
Spaan
Peter
P
Hunter
Juergen
J
Weese
Helko
H
Lehmann
Dominique
D
Chapelle
Reza
R
Rezavi