Oral manifestations in patients with hypogammaglobulinemia.
OBJECTIVE
The overall objective of this study was to assess the oral manifestations and their association with immunologic status and health history, of individuals with hypogammaglobulinemia.


METHODS
A case-controlled study of 100 subjects with hypogammaglobulinemia and 93 control individuals was performed. All participants were examined for dental caries, periodontal disease, mucosal lesions/infections, and general oral health problems. Decayed, missing, filled teeth and community periodontal index were recorded. Complete blood count, serum immunoglobulins, and lymphocyte immunophenotyping were measured on the same day of the oral health assessment.


RESULTS
Individuals with hypogammaglobulinemia showed higher prevalence of enamel hypoplasia and complaints of dry mouth, and lower prevalence of dental caries and periodontal disease.


CONCLUSIONS
The systemic conditions associated with hypogammaglobulinemia were not associated with enhanced susceptibility to caries, gingivitis, or periodontitis; however, individuals with hypogammaglobulinemia were more likely to report more episodes of recurrent aphthous ulcers compared with control individuals.
Post-graduate student, Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Karin Sá
KS
Fernandes
Cristina Maria
CM
Kokron
Myrthes Toledo
MT
Barros
Jorge
J
Kalil
Marina
M
Gallottini
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001772:Blood Cell Count; D017252:CD3 Complex / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D016022:Case-Control Studies; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology; D003744:Dental Enamel Hypoplasia / Q000209:etiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007694:Killer Cells, Natural / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology*; D010510:Periodontal Diseases / Q000209:etiology; D010512:Periodontal Index; D013281:Stomatitis, Aphthous / Q000209:etiology; D013283:Stomatitis, Herpetic / Q000209:etiology; D013601:T-Lymphocytes / Q000145:classification; D014987:Xerostomia / Q000209:etiology; D055815:Young Adult
D017252:CD3 Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M