Synthesis of some novel thiocyanotopurine derivatives and investigation of their antimicrobial activity and DNA interactions.
A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.
Department of Chemistry, Gazi University, Teknikokullar, Ankara, Turkey.
Gülay
G
Dilek Çelik
Ali
A
Dişli
Yağmur
Y
Öner
Leyla
L
Açık
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004247:DNA