Rapid characterization of perfluoralkyl carboxylate, sulfonate, and sulfonamide isomers by high-performance liquid chromatography-tandem mass spectrometry.
A rapid (<23 min) new HPLC-MS/MS method was developed for simultaneous characterization of 24 per- and polyfluoroalkyl compounds in landfill leachate. In addition to isomer-specific analysis of perfluorooctane sulfonate and perfluorooctanoate, branched from linear isomer separation was accomplished for C6 and C10 perfluoroalkyl sulfonates, C6, C7 and C9-C11 perfluoroalkyl carboxylates, perfluorooctane sulfonamide and, for the first time, 3 perfluorooctane sulfonamidoacetates. The method utilizes a fused-core pentafluorophenylpropyl (PFP) stationary phase and is approximately 4 times faster than previous comprehensive isomer-specific HPLC-MS/MS methods. This is the first isomer-specific methodology which can be adopted for routine analysis without sacrificing throughput from lengthy run times or limited target lists.
AXYS Analytical Services Ltd., Sidney BC, Canada V8L5X2. jbenskin@axys.com
Jonathan P
JP
Benskin
Michael G
MG
Ikonomou
Million B
MB
Woudneh
John R
JR
Cosgrove
D017738:Alkanesulfonic Acids / Q000737:chemistry*; D002210:Caprylates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005466:Fluorocarbons / Q000737:chemistry*; D007536:Isomerism; D015203:Reproducibility of Results; D013449:Sulfonamides / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons; D013449:Sulfonamides; C063900:perfluorooctanesulfonamide; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid