Involvement of long noncoding RNAs in diseases affecting the central nervous system.
DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies have uncovered that many human genomic sequences are transcribed but not translated, generating an astounding diversity of noncoding RNAs (ncRNAs). This awareness should be taken into account when studying human diseases and may have profound implications on the development of novel biomarkers as well as therapies.
Department of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Chiara
C
Pastori
Claes
C
Wahlestedt
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D025063:Chromosome Disorders / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D018392:Genomic Imprinting; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*
D062085:RNA, Long Noncoding