Association between serum platelet-derived growth factor BB and degree of liver damage, fibrosis and hepatitis B e antigen (HBeAg) status in CHB patients.
OBJECTIVE
The objective of this study was to determine the association of PDGF-BB with degree of liver damage, fibrosis and HBeAg status in CHB patients.


METHODS
A total of 740 patients with previously untreated chronic hepatitis B were included in the study. We conducted the correlations analysis of se-rum PDGF-BB with the age, gender, medical history, se-rum HBV-DNA, liver function parameters and serum fibrosis markers (HA, PCIII, CIV, LN), analyzed the cor-relations of degree of liver damage with liver fibrosis markers and the serum levels of PDGF-BB and compared serum liver fibrosis markers and levels of PDGF- BB between HbeAg-negative and HbeAg-positive CHB patients.


RESULTS
Liver function parameters and se-rum liver fibrosis markers were significantly correlated with serum PDGF-BB (p<0.01). Liver fibrosis markers and serum levels of PDGF-BB in CHB were positive correlated with degree of liver damage. Serum levels of PDGF-BB in HBeAg-negative CHB was significantly higher than that in the HBeAg-positive CHB (p<0.05).


CONCLUSIONS
Serum levels of PDGF-BB can reflect degree of liver damage and degree of liver fibrosis in CHB.Serum levels of PDGF-BB in HBeAg-negative CHB were higher than the HBeAg-positive CHB.
Department of Infectious Diseases, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiang-Chun
XC
Diang
Li-Na
LN
Ma
Yu-Fang
YF
Li
Xiao-Yan
XY
Liu
Xu
X
Zhang
Jun-Ying
JY
Liu
Yun-Jian
YJ
Sheng
Da-Zhi
DZ
Zhang
Huai-Dong
HD
Hu
Hong
H
Ren
D000293:Adolescent; D000328:Adult; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D020574:Proto-Oncogene Proteins c-sis / Q000097:blood*; D012720:Severity of Illness Index; D015854:Up-Regulation; D019562:Viral Load; D055815:Young Adult
D015415:Biomarkers; D004279:DNA, Viral; D006513:Hepatitis B e Antigens; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin