Autopsy case of delayed anaphylactic shock due to contrast medium.
We report an autopsy case of delayed anaphylactic shock due to contrast medium. A 17-year-old Japanese man underwent angiography using non-ionic contrast medium under the suspected diagnosis of Buerger's disease. Initial symptoms appeared 6 h after the administration of the contrast medium, and death was confirmed 11 h later. Considering the clinical course and the results of the autopsy, we concluded that the direct cause of the patient's death was severe acute circulatory failure due to a delayed allergic reaction to the contrast medium. The reported incidence of serious delayed reactions or biphasic reactions to non-ionic contrast medium is extremely low; however, we should be aware of such rare adverse reactions.
Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan. yanagai@showa.gunma-u.ac.jp
Yayoi
Y
Nagai
Yuko
Y
Tanaka
Yoichi
Y
Nakazato
Nobuyuki
N
Sugawara
Miho
M
Arai
Etsuko
E
Okada
Yoshinari
Y
Koyama
Hiroshi
H
Hinohara
Koujirou
K
Yamamoto
Masahiko
M
Kurabayashi
Yoshihisa
Y
Nojima
Osamu
O
Ishikawa
D000293:Adolescent; D000707:Anaphylaxis / Q000209:etiology* / Q000473:pathology*; D001344:Autopsy; D003287:Contrast Media / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology*; D008297:Male; D011859:Radiography; D012769:Shock / Q000401:mortality; D013919:Thromboangiitis Obliterans / Q000000981:diagnostic imaging*
D003287:Contrast Media