Synthetic biology, inspired by synthetic chemistry.
The topic synthetic biology appears still as an 'empty basket to be filled'. However, there is already plenty of claims and visions, as well as convincing research strategies about the theme of synthetic biology. First of all, synthetic biology seems to be about the engineering of biology - about bottom-up and top-down approaches, compromising complexity versus stability of artificial architectures, relevant in biology. Synthetic biology accounts for heterogeneous approaches towards minimal and even artificial life, the engineering of biochemical pathways on the organismic level, the modelling of molecular processes and finally, the combination of synthetic with nature-derived materials and architectural concepts, such as a cellular membrane. Still, synthetic biology is a discipline, which embraces interdisciplinary attempts in order to have a profound, scientific base to enable the re-design of nature and to compose architectures and processes with man-made matter. We like to give an overview about the developments in the field of synthetic biology, regarding polymer-based analogs of cellular membranes and what questions can be answered by applying synthetic polymer science towards the smallest unit in life, namely a cell.
University of Basel, Department of Chemistry, Klingelbergstr. 80, CH-4056 Basel, Switzerland. vmalinova@unibas.ch
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Malinova
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Nallani
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Meier
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Sinner
D058045:Artificial Cells / Q000378:metabolism; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D036103:Nanotechnology; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D058615:Synthetic Biology / Q000379:methods*
D008565:Membrane Proteins; D011108:Polymers