Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease.
OBJECTIVE
To report the restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease after autotransplantation of cryopreserved ovarian cortex.


METHODS
Case report.


METHODS
Gynecology research unit in a university hospital.


METHODS
A 28-year-old woman who underwent bilateral adnexectomy for ovarian abscesses at the age of 18 years.


METHODS
We performed ovarian cortex autotransplantation to a peritoneal pocket in the broad ligament.


METHODS
Restoration of ovarian activity and pregnancy.


RESULTS
Restoration of ovarian function began at 20 weeks and was achieved 24 weeks after transplantation. After the fifth stimulation attempt, two mature oocytes were obtained and microinjected. One embryo (seven cells) was obtained and transferred, leading to a normal pregnancy. The patient delivered a healthy baby boy weighing 2,370 g at 38 weeks of gestation.


CONCLUSIONS
Ovarian cortex cryopreservation can be performed at the time of surgery for benign diseases when fertility is impaired. We report the first pregnancy to occur after ovarian tissue cryopreservation for benign ovarian pathology after bilateral oophorectomy.
Department of Gynecology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, and Institut de Recherche Expérimentale et Clinique, Pôle de Gynécologie, Université Catholique de Louvain, Brussels, Belgium. jacques.donnez@uclouvain.be
Jacques
J
Donnez
Pascale
P
Jadoul
Céline
C
Pirard
Graham
G
Hutchings
Dominique
D
Demylle
Jean
J
Squifflet
Johan
J
Smitz
Marie-Madeleine
MM
Dolmans
D000038:Abscess / Q000601:surgery*; D000328:Adult; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D010049:Ovarian Diseases / Q000601:surgery*; D010052:Ovariectomy; D010053:Ovary / Q000637:transplantation*; D011247:Pregnancy; D014182:Transplantation, Autologous