[Characteristics of sleep apnea syndrome in a cohort of patients with acromegaly].
BACKGROUND
Sleep apnoea syndrome (SAS) has a prevalence of between 40 and 80 % in patients with acromegaly. The objective of our study was to focus on the occurrence of SAS and its relation with acromegalic characteristics in this population as well as to study patients' comorbidities.


METHODS
This study was retrospective, monocentric and related to a cohort of 106 acromegalic patients of whom 55 patients had performed ventilatory polygraphic recordings looking for SAS in addition to assessment of comorbidities.


RESULTS
Within the screened patients, 42 had sleep apnoea syndrome with a majority of them having severe SAS. In this population, SAS was associated with hypertension, diabetes and a longer duration of acromegaly but acromegaly control was not a risk factor. Patients with severe SAS were older (mean 64 years) than the ones without SAS (47 years) (P=0.01).


CONCLUSIONS
SAS prevalence is twenty times higher in the acromegalic population than for the normal population, even more so if patients are diabetic, hypertensive, older and if acromegaly has had a long evolution. Knowing this high prevalence, systematic screening for SAS may be justified in this population.
Service de pneumologie-allergologie, hôpital Larrey, CHU de Toulouse, 24 chemin de Pouvourville, Toulouse, France.
M
M
Chevallier
S
S
Pontier
K
K
Sedkaoui
P
P
Caron
A
A
Didier
D000172:Acromegaly / Q000150:complications* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology