Effect of magnesium supplementation on the distribution patterns of zinc, copper, and magnesium in rabbits exposed to prolonged cadmium intoxication.
The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO₃ and HClO₄ (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.
Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia. zorica.bulat@pharmacy.bg.ac.rs
Zorica
Z
Bulat
Danijela
D
Dukić-Ćosić
Biljana
B
Antonijević
Petar
P
Bulat
Dragana
D
Vujanović
Aleksandra
A
Buha
Vesna
V
Matović
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000378:metabolism*; D019587:Dietary Supplements; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects; D011817:Rabbits; D014018:Tissue Distribution / Q000187:drug effects*; D016896:Treatment Outcome; D015032:Zinc / Q000378:metabolism*
D002104:Cadmium; D003300:Copper; D008274:Magnesium; D015032:Zinc