Polyphenols: key issues involved in chemoprevention of prostate cancer.
Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.
Department of Urology, University of Catania, 95125 Catania, Italy. ciminonello@hotmail.com
Sebastiano
S
Cimino
Giuseppe
G
Sortino
Vincenzo
V
Favilla
Tommaso
T
Castelli
Massimo
M
Madonia
Salvatore
S
Sansalone
Giorgio Ivan
GI
Russo
Giuseppe
G
Morgia
D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D003474:Curcumin / Q000737:chemistry / Q000627:therapeutic use; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use; D019833:Genistein / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008297:Male; D059808:Polyphenols / Q000737:chemistry / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D011794:Quercetin / Q000737:chemistry / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000627:therapeutic use
D000975:Antioxidants; D005419:Flavonoids; D059808:Polyphenols; D013267:Stilbenes; D002392:Catechin; D011794:Quercetin; C045651:epigallocatechin gallate; D019833:Genistein; D003474:Curcumin; D000077185:Resveratrol