KiSS1 and its G-protein-coupled receptor GPR54 in cancer development and metastasis.
KiSS1 and its cognate G-protein-coupled receptor, GPR54, have diverse functions. While KiSS1 and GPR54 have been intensively studied in physiology, their role in cancer is still unclear. In cancer, KiSS1 and GPR54 have been known to suppress metastasis by inhibiting cancer cell motility. However, recent studies suggest that KiSS1 and GPR54 have varied roles even in cancer development and metastasis. Here, we examine recent advances in understanding the roles of KiSS1 and GPR54 in cancer development and metastasis.
Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA.
Sung-Gook
SG
Cho
Dali
D
Li
Kunrong
K
Tan
Stefan K
SK
Siwko
Mingyao
M
Liu
D000818:Animals; D006801:Humans; D059648:Kisspeptins / Q000502:physiology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D000074502:Receptors, Kisspeptin-1; D015398:Signal Transduction
C106628:KISS1 protein, human; C118688:KISS1R protein, human; D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1