Prognostic significance of relevant markers of cancer stem cells in colorectal cancer - a meta analysis.
OBJECTIVE
To evaluate the correlation between the expression of stem cell makers and prognosis in colorectal cancer.


METHODS
Eligible studies evaluating the correlation between stem cell makers and prognosis were selected based on the references in PubMed, Embase and Cochrane libraries. Outcome measures included overall survival, relevant pathological parameters. Meta-analyses were performed by RevMan 5.0.


RESULTS
Seventeen eligible articles involving 3098 patients were included. Meta-analysis showed CD44 expression is not significant difference of 5-year overall survival rate (OR=0.69, p=0.22) and relevant clinical parameters, such as histological grade (OR=1.98, p=0.06), dukes grade (OR=0.77, p=0.43) and metastasis (OR=1.03, p=0.89). Likewise, there is no correlation between CD44v6 and dukes stage (OR=0.56, p=0.23), metastasis (OR= 2.81, p=0.33), except for histological grade (OR=0.48, p=0.02). However, CD44v6 positive cells (OR=0.36, p=0.02) were significantly associated with poor overall survival.


CONCLUSIONS
Based on current retrospective evidence, a stem cell maker, CD44 cannot become a prognostic marker in colorectal cancer. In contrast, CD44v6, an isoform of CD44 plays a significant role to predict clinic outcome.
Institute of Digestive Surgery, Sichuan University, Chengdu, China.
Chuan-Wen
CW
Fan
Lei
L
Wen
Zhong-De
ZD
Qiang
Tie
T
Chen
Zong-Guang
ZG
Zhou
Xian-Ming
XM
Mo
Jian-Kun
JK
Hu
D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016001:Confidence Intervals; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D060787:Neoplasm Grading; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D016017:Odds Ratio; D011379:Prognosis
D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors