[LDL-cholesterol homogeneous assays versus Friedewald's equation].
Low-density lipoprotein (LDL) is an important risk factor for coronary artery disease as well as ischemic stroke. In clinical practice, LDL-cholesterol (LDL-C) is calculated by Friedewald's equation or determined by homogeneous assays for LDL-C. Although Friedewald's equation has some limitations, it has been widely used for LDL-C measurement for nearly 40 years. On the other hand, the first LDL-C homogeneous assay was developed in the late 1990s. New reagents have appeared on the market one after another, and 12 homogeneous assays are now available in Japan; however, they measure LDL-C by different principles, which are not disclosed to the public. There is some debate about which method is superior for LDL-C measurement of clinical samples.
Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. tmiida@juntendo.ac.jp
Takashi
T
Miida
Satoshi
S
Hirayama
D008078:Cholesterol, LDL / Q000097:blood*; D019411:Clinical Laboratory Techniques / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis; D006801:Humans; D020521:Stroke / Q000175:diagnosis
D008078:Cholesterol, LDL