Brain structural and functional recovery following initiation of combination antiretroviral therapy.
NeuroAIDS persists in the era of combination antiretroviral therapies. We describe here the recovery of brain structure and function following 6 months of therapy in a treatment-naive patient presenting with HIV-associated dementia. The patient's neuropsychological test performance improved and his total brain volume increased by more than 5 %. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. beckerjt@upmc.edu
James T
JT
Becker
Pablo
P
Cuesta
Melissa
M
Fabrizio
Gustavo
G
Sudre
Emanuel N
EN
Vergis
Antoine
A
Douaihy
Ricardo
R
Bajo
Allie
A
Schubert
Oscar L
OL
Lopez
Lauri
L
Parkkonen
Fernando
F
Maestu
Anto
A
Bagic
D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects; D004359:Drug Therapy, Combination; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000187:drug effects / Q000473:pathology; D009483:Neuropsychological Tests
D019380:Anti-HIV Agents