Sox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors.
Neural precursor cells play important roles in the neocortical development, but the mechanisms of neural progenitor proliferation, neuronal differentiation, and migration, as well as patterning are still unclear. Sox11, one of SoxC family members, has been reported to be essential for embryonic and adult neurogenesis. But there is no report about the roles of Sox11 in corticogenesis. In order to investigate Sox11 function during cortical development, loss of function experiment was performed in this study. Knockdown of Sox11 by Sox11 siRNA constructs resulted in a diminished neuronal differentiation, but enhanced proliferation of intermediate progenitors. Accompanied with the high expression of Sox11 in the postmitotic neurons, but low expression of Sox11 in the dividing neural progenitors, all the observations indicate that Sox11 induces neuronal differentiation during the neocortical development.
Department of Neurosurgery, The 2nd Affiliated Hospital, Harbin Medical University, Harbin 150086,  China.
Yongzhe
Y
Li
Jianjiao
J
Wang
Yongri
Y
Zheng
Yan
Y
Zhao
Mian
M
Guo
Yang
Y
Li
Qiuli
Q
Bao
Yu
Y
Zhang
Lizhuang
L
Yang
Qingsong
Q
Li
D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D049109:Cell Proliferation; D018274:Electroporation; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry / Q000379:methods; D051379:Mice; D008957:Models, Genetic; D008969:Molecular Sequence Data; D019579:Neocortex / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D016366:Open Reading Frames; D012333:RNA, Messenger / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D055751:SOXC Transcription Factors / Q000235:genetics / Q000502:physiology*; D013997:Time Factors
D012333:RNA, Messenger; D034741:RNA, Small Interfering; D055751:SOXC Transcription Factors; C490793:Sox11 protein, mouse