Kaposi sarcoma: review and medical management update.
Despite recent advances in our understanding of pathogenic mechanisms involved, the true nature of Kaposi sarcoma remains an enigma. Four clinical variants have been described for the disease, differing in natural history, site of predilection, and prognosis. All forms of Kaposi sarcoma may manifest in the oral cavity and Kaposi sarcoma-associated virus appears essential to development of all clinical variants. The spectrum of therapeutic strategies is broad and selection of appropriate intervention mandates a thorough understanding of disease spread and the patient's symptomatology, as well as risks and benefits of therapy. This article provides an overview of epidemiology, subtypes, clinical course, pathogenesis, and management strategies for Kaposi sarcoma.
Division of Oral Medicine, Department of Diagnostic Sciences, New Jersey Dental School-UMDNJ, Newark, NJ 07103, USA. fatahza@umdnj.edu
Mahnaz
M
Fatahzadeh
D000970:Antineoplastic Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D017742:Dental Care for Chronically Ill / Q000379:methods*; D006566:Herpesviridae Infections / Q000097:blood / Q000635:transmission; D019288:Herpesvirus 8, Human; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy* / Q000821:virology; D011878:Radiotherapy; D012514:Sarcoma, Kaposi / Q000473:pathology* / Q000628:therapy* / Q000821:virology
D000970:Antineoplastic Agents