Silicone-coated non-woven polyester dressing enhances reepithelialisation in a sheep model of dermal wounds.
Negative-pressure wound therapy (NPWT) also known as V.A.C. (Vacuum-assisted closure), is widely used to manage various type of wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane (PU) foam or medical gauze. In this study an experimental setup of sheep wound model was used to evaluate, under NPWT conditions, the performance of a silicone-coated non-woven polyester (N-WPE) compared with PU foam and cotton hydrophilic gauze, used as reference materials. Animals were anesthetized with spontaneous breathing to create three 3 × 3 cm skin defects bilaterally; each animal received three different samples on each side (n = 6 in each experimental group) and was subjected to negative and continuous 125 mmHg pressure up to 16 days. Wound conditions after 1, 8 and 16 days of treatment with the wound dressings were evaluated based on gross and histological appearances. Skin defects treated with the silicone-coated N-WPE showed a significant decrease in wound size, an increase of re-epithelialization, collagen deposition and wound neovascularisation, and a minimal stickiness to the wound tissue, in comparison with gauze and PU foam. Taken all together these findings indicate that the silicone-coated N-WPE dressing enhances wound healing since stimulates higher granulation tissue formation and causes minor tissue trauma during dressing changes.
Laboratory for Biomaterials and Graft Technology, Institute of Clinical Physiology (CNR), via Aurelia Sud, 54100, Massa, Italy.
Paola
P
Losi
Enrica
E
Briganti
Manolo
M
Costa
Elena
E
Sanguinetti
Giorgio
G
Soldani
D019412:Anatomy, Cross-Sectional; D000818:Animals; D001458:Bandages; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020405:Dermis / Q000033:anatomy & histology / Q000293:injuries* / Q000473:pathology / Q000648:ultrastructure; D004195:Disease Models, Animal; D054843:Negative-Pressure Wound Therapy / Q000295:instrumentation / Q000379:methods; D009779:Occlusive Dressings; D010539:Permeability / Q000187:drug effects; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D062326:Re-Epithelialization / Q000187:drug effects / Q000502:physiology*; D012756:Sheep; D012828:Silicones / Q000737:chemistry* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D020099:Coated Materials, Biocompatible; D011091:Polyesters; D012828:Silicones