Rapid continuous synthesis of 5'-deoxyribonucleosides in flow via Brønsted acid catalyzed glycosylation.
A general, green, and efficient Brønsted acid-catalyzed glycosylation serves as a key step in the one-flow, multistep syntheses of several important 5'-deoxyribonucleoside pharmaceuticals.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Bo
B
Shen
Timothy F
TF
Jamison
D000097:Acetonitriles / Q000737:chemistry*; D002384:Catalysis; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D011726:Pyridinium Compounds / Q000737:chemistry*
D000097:Acetonitriles; D003853:Deoxyribonucleosides; D008698:Mesylates; D011726:Pyridinium Compounds; C032159:acetonitrile