[Taurine induces apoptosis in pulmonary artery smooth muscle cells].
OBJECTIVE
To study the effect of taurine on apoptosis in PASMCs, and whether the death-receptor pathway act in the mechanism.


METHODS
Culture the PASMCs, and divided the cells into control, SD. Acridine orange(AO) assay and western-blot analysis on the expression of Bax, Bcl-2, Procaspase-3 and Fas were used to study the mechanism.


RESULTS
A major finding of this study is that the Tau effects many apoptosis index, such as increasing the expression of Bax and Fas, decreasing the expression of Procaspase-3, and Bcl-2, accrescencing the mitochondrial depolarization, causing the nuclear shrinkage, all these datas demonstrated that Tau induced the apoptosis in pulmonary artery smooth muscle cells through mitochondrial-dependent pathway.


CONCLUSIONS
Tau induces the apoptosis in pulmonary artery smooth muscle cells through death-receptor.
Harbin University of Commerce, Harbin 150076, China. zhangxd85@163.com
Xiaodan
X
Zhang
Jiejing
J
Sheng
Caixiaz
C
Zhang
Fenghua
F
Zhao
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D032389:Myocytes, Smooth Muscle / Q000187:drug effects*; D011651:Pulmonary Artery / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine