Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL).
A lady in her late 20s was admitted with a history of headaches and intermittent focal neurological symptoms which were greatly exacerbated by catheter angiography of the cerebral circulation. Cerebrospinal fluid analysis demonstrated a lymphocytic pleocytosis. She subsequently made a spontaneous recovery, without neurological sequelae. Her presentation fits the diagnostic criteria for the previously described syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL). HaNDL is a probably underdiagnosed nosological entity, characterised by often dramatic clinical manifestations but ultimately a good prognosis.
Department of Neurology, Queen's Hospital, Romford, Essex, UK. Alberto.Cifelli@nhs.net
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Cifelli
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Vaithianathar
D000328:Adult; D005260:Female; D006261:Headache / Q000175:diagnosis*; D006801:Humans; D008218:Lymphocytosis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D009422:Nervous System Diseases / Q000175:diagnosis*; D013577:Syndrome