Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.
The purpose of the current study was to determine whether a tropical ginger derived compound 1'-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Vinita
V
Batra
Zanobia
Z
Syed
Jennifer N
JN
Gill
Malari A
MA
Coburn
Patrick
P
Adegboyega
John
J
DiGiovanni
J Michael
JM
Mathis
Runhua
R
Shi
John L
JL
Clifford
Heather E
HE
Kleiner-Hancock
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D032429:Alpinia / Q000737:chemistry; D000818:Animals; D001592:Benzyl Alcohols / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D001592:Benzyl Alcohols; D016328:NF-kappa B; D010936:Plant Extracts; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D005446:Fluocinolone Acetonide; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate; C047948:1'-acetoxychavicol acetate