Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings.
A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Ya Lin
YL
Tnay
Cheng
C
Chen
Yi Yuan
YY
Chua
Line
L
Zhang
Shunsuke
S
Chiba
D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D053138:Cyclohexenes / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*
D001372:Aza Compounds; D053138:Cyclohexenes; D007097:Imines; D009942:Organometallic Compounds; D013141:Spiro Compounds; C507608:cyclohexadienone; D003300:Copper; D010100:Oxygen