[Association study of polymorphic markers of F12, PON1, PON2, NOS2, PDE4D, HIF1a, GPIba, CYP11B2 genes with ischemic stroke in Russian patients].
Allele and genotype frequencies of 10 single nucleotide polymorphisms in F12, PON1, PON2, NOS2, PDE4D, HIF1a,GPIba, CYP11B2 genes were studied in a group of Russian patients with ischemic stroke (IS) from central regions of the Russian Federation and healthy donors matched for sex, age and ethnicity. The genotyping procedure included the amplification of selected DNA sequences with the following hybridization of fluorescently-labeled regions with allele-specific DNA-probes immobilized on a biochip. An analysis of allele and genotype frequencies for each gene in IS patients and controls did not reveal any significant differences. The pair-wise comparison of genes demonstrated that the frequency of the combination PON1A/-x PON2 GG was higher in the group of patients (p=0.044, OR=3.4 95% CI 1.06 − 10.4) compared to the controls and, thus, was associated with the higher risk for stroke.
M A
MA
Avdonina
T V
TV
Nasedkina
A Iu
AIu
Ikonnikova
E V
EV
Bondarenko
P A
PA
Slominskiĭ
N A
NA
Shamalov
I M
IM
Shetova
S A
SA
Limborskaia
A S
AS
Zasedatelev
V I
VI
Skvortsova
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000235:genetics; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000235:genetics; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics; D004252:DNA Mutational Analysis; D005174:Factor XII / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000235:genetics; D019038:Platelet Glycoprotein GPIb-IX Complex; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
D005819:Genetic Markers; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008562:Membrane Glycoproteins; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor; D005174:Factor XII; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D019405:Cytochrome P-450 CYP11B2; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human