HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth.
Cancer cells in culture obtain ATP and biosynthetic precursors primarily by aerobic glycolysis, not by mitochondrial glucose oxidation. In this issue of Cell Metabolism, Marin-Valencia et al. (2012) demonstrate that glioblastoma, an aggressive and, in culture, highly glycolytic cancer, primarily uses glucose oxidation to meet energetic and biosynthetic demands in vivo.
Departments of Pathology and Laboratory Medicine and Molecular and Medical Pharmacology, The David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA. pmischel@mednet.ucla.edu
Paul S
PS
Mischel