Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
Bioassay-guided isolation of the CH(2)Cl(2)/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC(50) values of 3.4 and 4.7 μM, respectively.
Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
Yunjiang
Y
Feng
Rohan A
RA
Davis
Melissa L
ML
Sykes
Vicky M
VM
Avery
Ronald J
RJ
Quinn
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002518:Ceramides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
D000962:Antimalarials; D002518:Ceramides; C534669:iotrochotamide I; C534670:iotrochotamide II