Evaluation of gastric processing and duodenal digestion of starch in six cereal meals on the associated glycaemic response using an adult fasted dynamic gastric model.
OBJECTIVE
To identify the key parameters involved in cereal starch digestion and associated glycaemic response by the utilisation of a dynamic gastro-duodenal digestion model.


METHODS
Potential plasma glucose loading curves for each meal were calculated and fitted to an exponential function. The area under the curve (AUC) from 0 to 120 min and total digestible starch was used to calculate an in vitro glycaemic index (GI) value normalised against white bread. Microscopy was additionally used to examine cereal samples collected in vitro at different stages of gastric and duodenal digestion.


RESULTS
Where in vivo GI data were available (4 out of 6 cereal meals) no significant difference was observed between these values and the corresponding calculated in vitro GI value.


CONCLUSIONS
It is possible to simulate an in vivo glycaemic response for cereals when the gastric emptying rate (duodenal loading) and kinetics of digestible starch hydrolysis in the duodenum are known.
Nofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, Norway. simon.ballance@nofima.no
Simon
S
Ballance
Stefan
S
Sahlstrøm
Per
P
Lea
Nina E
NE
Nagy
Petter V
PV
Andersen
Tzvetelin
T
Dessev
Sarah
S
Hull
Maria
M
Vardakou
Richard
R
Faulks
D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D004041:Dietary Fats / Q000032:analysis; D004044:Dietary Proteins / Q000032:analysis; D004063:Digestion / Q000502:physiology; D004386:Duodenum / Q000378:metabolism*; D002523:Edible Grain / Q000737:chemistry*; D005215:Fasting; D005511:Food Handling; D038321:Glycemic Index; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007091:Image Processing, Computer-Assisted; D062407:Meals; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D008954:Models, Biological; D011134:Polysaccharides / Q000032:analysis; D013213:Starch / Q000378:metabolism*; D014783:Viscosity; D055815:Young Adult; D047071:beta-Glucans / Q000032:analysis
D001786:Blood Glucose; D004041:Dietary Fats; D004044:Dietary Proteins; D011134:Polysaccharides; D047071:beta-Glucans; D013213:Starch