Systemic therapy in the management of metastatic or advanced salivary gland cancers.
Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia. Electronic address: aymen.lagha@hotmail.com.
Aymen
A
Lagha
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Nesrine
N
Chraiet
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Mouna
M
Ayadi
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Sarra
S
Krimi
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Bassem
B
Allani
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Hela
H
Rifi
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Henda
H
Raies
Department of Medical Oncology, Salah Azaiez Institute, Tunis, Tunisia.
Amel
A
Mezlini
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009362:Neoplasm Metastasis; D011446:Prospective Studies; D012468:Salivary Gland Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal