[The application of intravenous laser irradiation of the blood for the combined treatment of psoriasis].
The objective of the present comparative study was to estimate the efficacy of the treatment of 104 patients presenting with psoriasis with the use of PUVA therapy and intravenous laser irradiation of the blood or the combination of the two methods. It was shown that the latter treatment caused a faster reduction of the inflammatory processes than the former whereas their joint application was especially efficacious in inducing regression of concomitant infiltrative events. Erythrocytes from the patients undergoing intravenous laser irradiation of the blood were characterized by the enhanced activity of antioxidative enzymes that are known to play an important role in the cellular protection from oxidants. At the same time, PUVA therapy caused no appreciable changes in the antioxidtive status. Both treatments increased the levels of antiinflammatory cytokines and decreased those ofproinflammatory ones which suggests their immunomodulatory effect that was especially pronounced in the case of combined therapy. It is concluded that the introduction of intravenous laser irradiation of the blood in the combined treatment of psoriatic patients exerts positive effect on compromised immunoregulation, stimulates the antioxidative system, and improves microcirculation.
A S
AS
Shakhova
A G
AG
Kulikov
I M
IM
Korsunskaia
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011701:PUVA Therapy; D011565:Psoriasis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*
D000975:Antioxidants; D016207:Cytokines