FeCl2-promoted cleavage of the unactivated C-C bond of alkylarenes and polystyrene: direct synthesis of arylamines.
Ironing it out: an efficient and convenient nitrogenation strategy involving C-C bond cleavage for the straightforward synthesis of versatile arylamines is presented. Various alkyl azides and alkylarenes, including the common industrial by-product cumene, react using this protocol. Moreover, this method provides a potential strategy for the degradation of polystyrene.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Chong
C
Qin
Tao
T
Shen
Conghui
C
Tang
Ning
N
Jiao
D000588:Amines / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000494:pharmacology*; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry* / Q000378:metabolism*
D000588:Amines; D001555:Benzene Derivatives; D005296:Ferrous Compounds; D011137:Polystyrenes; D002244:Carbon; C029451:ferrous chloride