[Experience with treatment of chronic polypoid rhinosinusitis using low doses of clarithromycin in the postoperative period].
A total of 37 patients at the age from 25 to 65 years presenting with chronic polipoid rhinosinusitis (CPRS) were available for the observation. They were allocated to two groups based on the results of endoscopic polyposinusotomy. The patients in group 1 (n=18) were instructed at discharge from the clinic to take 250 mg of clarithromycin daily for 3 months in combination with the local application of a topical corticosteroid. The patients in group 2 (n=19) were prescribed topical corticosteroids alone. It was shown that clarithromycin at low doses caused significant stabilization of CPRS remission and prevented the development of relapses in the majority of the patients (66%). Therapy of CPRS with low doses of clarithromycin was associated with a significant decrease of the frequency of acute retroviral infections (ARVI). The intake of clarithromycin had no effect on the development and/or aggravation of intestinal dysbacteriosis nor did it provoke deviation of blood biochemical characteristics from the normal values both at the onset of therapy and after a follow-up period of 3 months.
G Z
GZ
Piskunov
T Iu
TIu
Bobacheva
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D017291:Clarithromycin / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D011184:Postoperative Period; D012220:Rhinitis / Q000188:drug therapy* / Q000517:prevention & control / Q000601:surgery; D055502:Secondary Prevention; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D017291:Clarithromycin