[Significance expression and relationships with endothelin-1, matrix metalloproteinase-9 in the laryngeal carcinoma].
OBJECTIVE
To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9 (MMP-9) in laryngeal carcinoma and their correlations with clinical features.


METHODS
The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.


RESULTS
The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues (P < 0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-land MMP-9 correlated significantly with each other (r(s) = 0.693, P < 0.05).


CONCLUSIONS
The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
Department of Otorhinolaryngology, the Second Affiliated.Hospital of Kunming Medical College, Kunming, 650101, China.
Yan
Y
Lin
Jingjing
J
Zhang
Shixi
S
Liu
Feng
F
Liu
Jian
J
Zou
Mingxiu
M
Zheng
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging
D019332:Endothelin-1; D020780:Matrix Metalloproteinase 9