Effects of beta-blocker use on volume status in hemodialysis patients.
BACKGROUND
Removal and control of excess fluid with dialysis is considered critical for protection against cardiovascular sequelae. Antihypertensive agents including beta-blockers may influence hemodynamics, which may limit fluid removal during hemodialysis (HD).


METHODS
Fifty chronic HD patients underwent bioimpedance measurement before and after a midweek dialysis session. Data on volume status, blood pressure, antihypertensive medications, and bioimpedance were analyzed.


RESULTS
Patients in the high-volume status group used a significantly higher percentage of beta-blockers than patients in the low-volume status group (54.2 vs. 19.2%, respectively, p = 0.01). Multivariable regression revealed that the use of beta-blockers was independently positively associated with fluid overload (p < 0.05). Intradialytic muscle cramping occurred more often in the beta-blocker group than the control group (44.4 vs. 12.5%, respectively, p = 0.02).


CONCLUSIONS
Our results suggest that the use of beta-blockers was associated with fluid overload in HD patients, and patients being treated with them experienced more intradialytic muscle cramping during dialysis.
Division of Nephrology, Peking University Third Hospital, Beijing, PR China. bishh6690@yahoo.com.cn
Shu-Hong
SH
Bi
Lori
L
Linke
Jimmy
J
Wu
Li-Tao
LT
Cheng
Tao
T
Wang
Suhail
S
Ahmad
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001834:Body Water / Q000187:drug effects / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000139:chemically induced; D006435:Renal Dialysis / Q000379:methods
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents