Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai.
Phytochemical investigation of Hypericum nakamurai (Masamune) Robson has led to the isolation of three phloroglucinol derivatives 1-3. The structures of these compounds were determined by the analysis of their spectroscopic data (IR, mass and UV), and by the application of 1-D and 2-D-NMR techniques. Hyperinakin (1) is a new compound. The anti-inflammatory activities of compounds 1-3 were also tested and evaluated. A biogenetic pathway for compounds 1-3 was also proposed.
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan.
Yuan-Bin
YB
Cheng
Ahmed Eid
AE
Fazary
Yu-Chi
YC
Lin
I-Wen
IW
Lo
Seow-Chin
SC
Ong
Shun-Ying
SY
Chen
Ching-Te
CT
Chien
Yen-Jung
YJ
Lin
Wan-Wan
WW
Lin
Ya-Ching
YC
Shen
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification*; D002460:Cell Line; D020902:Hypericum / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; C586232:hyperinakin; D010696:Phloroglucinol