[Progress and extensive meaning of mammalian target of rapamycin involved in restoration of nervous system injury].
OBJECTIVE
To review the possible mechanisms of the mammalian target of rapamycin (mTOR) in the neuronal restoration process after nervous system injury.


METHODS
The related literature on mTOR in the restoration of nervous system injury was extensively reviewed and comprehensively analyzed.


RESULTS
mTOR can integrate signals from extracellular stress and then plays a critical role in the regulation of various cell biological processes, thus contributes to the restoration of nervous system injury.


CONCLUSIONS
Regulating the activity of mTOR signaling pathway in different aspects can contribute to the restoration of nervous system injury via different mechanisms, especially in the stress-induced brain injury. mTOR may be a potential target for neuronal restoration mechanism after nervous system injury.
Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu Sichuan 610041, PR China.
Hongju
H
Chen
Binzhi
B
Tang
Yi
Y
Qu
Dezhi
D
Mu
D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D018384:Oxidative Stress; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020196:Trauma, Nervous System / Q000378:metabolism* / Q000503:physiopathology
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009419:Nerve Tissue Proteins; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus