Spontaneous splenic rupture: an unusual presentation of CML.
A 47-year-old man presented with sudden onset of severe, generalised abdominal pain and collapse. He also had a 4-month history of lethargy and weight loss. On examination he was shocked with a distended tender abdomen. He had haemoglobin of 3.8 g/dl and a white cell count count of 280.3×10(9)/l with predominance of neutrophils. Arterial gases showed mixed metabolic-respiratory acidosis. A CT scan of abdomen showed active extravasation in splenic bed. In view of probable hyperviscosity syndrome, it was decided to attempt an angiographic embolisation. This was successfully carried out but 4 h later, he developed abdominal compartment syndrome and underwent a laparotomy and splenectomy. Subsequently, bone marrow aspirates were taken which showed granulocytic hyperplasia. Cytogenetic studies confirmed the presence of Philadelphia Chromosome and he was started on Imatinib. It is now 5 months since diagnosis and he has achieved complete haematological and cytogenetic response.
Department of General Surgery, Royal Hallamshire Hospital, Sheffield, UK. sjafferbhoy@doctors.org.uk
Sadaf
S
Jafferbhoy
Andrew
A
Chantry
Neil
N
Atkey
Douglas
D
Turner
Lynda
L
Wyld
D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012422:Rupture, Spontaneous / Q000175:diagnosis / Q000209:etiology; D013161:Splenic Rupture / Q000175:diagnosis / Q000209:etiology*