An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi.
OBJECTIVE
To determine if supplementation with corn-soya blend (CSB) or lipid-based nutrient supplement (LNS) improved the weight gain of moderately underweight infants and children when provided through the national health service.


METHODS
A randomised, controlled, assessor-blinded clinical trial. Infants and children were randomised to receive for 12 weeks an average daily ration of 71 g CSB or 43 g LNS, providing 1188 kJ and 920 kJ, respectively, or no supplement (control). Main outcome was weight gain. Secondary outcomes included changes in anthropometric indices and incidence of serious adverse events. Intention-to-treat analyses were used.


METHODS
Kukalanga, Koche, Katema and Jalasi health centres in Mangochi District, rural Malawi.


METHODS
Underweight (weight-for-age Z-score <-2) infants and children aged 6-15 months (n 299).


RESULTS
Mean weight gain was 630 g, 680 g and 750 g in control, CSB and LNS groups, respectively (P = 0·21). When adjusted for baseline age, children receiving LNS gained on average 90 g more weight (P = 0·185) and their weight-for-length Z-score increased 0·22 more (P = 0·049) compared with those receiving no supplementation. No statistically significant differences were observed between the CSB and control groups in mean weight and length gain.


CONCLUSIONS
LNS supplementation provided during the lean season via through the national health service was associated with a modest increase in weight. However, the effect size was lower than that previously reported under more controlled research settings.
Department of Community Health, College of Medicine, University of Malawi, Private Bag 360, Chichiri Blantyre 3, Malawi.
Chrissie M
CM
Thakwalakwa
Per
P
Ashorn
Mpumulo
M
Jawati
John C
JC
Phuka
Yin Bun
YB
Cheung
Kenneth M
KM
Maleta
D019587:Dietary Supplements; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008295:Malawi / Q000453:epidemiology; D012424:Rural Population; D013025:Glycine max; D013851:Thinness / Q000453:epidemiology*; D015430:Weight Gain; D003313:Zea mays