Synthesis and biological evaluation of vinyl ether-containing azole derivatives as inhibitors of Trichophyton rubrum.
In an attempt to search for many target compounds with excellent activities, a series of vinyl ether-containing azole derivatives were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against Trichophyton rubrum in vitro indicated that most of the synthesized compounds showed excellent activities. In comparison with fluconazole, itraconazole, voriconazole, omoconazole and amphotericin B, several compounds (such as 7d, 7g and 7h) exhibited more potent inhibitory activities, suggesting that they were promising leads for the development of novel antifungal agents.
College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China.
Lulu
L
Wang
Wenge
W
Yang
Kai
K
Wang
Jing
J
Zhu
Fei
F
Shen
Yonghong
Y
Hu
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001393:Azoles / Q000737:chemistry*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects*; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D001393:Azoles; D014753:Vinyl Compounds; C100195:vinyl ether