New ruthenium(II) complexes functionalized with coumarin derivatives: synthesis, energy-transfer-based sensing of esterase, cytotoxicity, and imaging studies.
Two new bichromophoric ruthenium(II) complexes, [Ru(bpy)(2)(bpy-CM)](PF(6))(2) and [Ru(bpy)(2)(bpy-CM343)](PF(6))(2) (bpy=2,2'-bipyridine, CM=coumarin) with appended coumarin ligands have been designed and synthesized. The energy-transfer-based sensing of esterase by the complexes has been studied by using UV/Vis and luminescence spectroscopic methods. The cytotoxicity and the cellular uptake of one of the complexes have also been investigated.
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China.
Mei-Jin
MJ
Li
Keith Man-Chung
KM
Wong
Changqing
C
Yi
Vivian Wing-Wah
VW
Yam
D000818:Animals; D003374:Coumarins / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004735:Energy Transfer; D004950:Esterases / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D049449:Luminescence; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry*; D013552:Swine
D003374:Coumarins; D009942:Organometallic Compounds; D012428:Ruthenium; D004950:Esterases