Rasburicase for huge hepatocellular carcinoma with tumor lysis syndrome: case report.
OBJECTIVE
To report a case of huge hepatocellular carcinoma associated with tumor lysis syndrome and its management.


METHODS
A 51-year-old hepatitis B carrier visited our clinic with progressive weight loss over recent months. Abdominal ultrasonography and magnetic resonance imaging revealed a huge hepatic mass in a cirrhotic liver, identified as hepatocellular carcinoma. A hepatologist and surgeon recommended transarterial chemoembolization followed by hepatectomy. The patient underwent the procedure, with the complication of tumor lysis syndrome. He was treated with a single high dose (9 mg) of rasburicase and his clinical condition improved dramatically, with acute kidney injury subsiding without emergent hemodialysis.


CONCLUSIONS
This was a case of hepatocellular carcinoma with tumor lysis syndrome and acute kidney injury, treated successfully with rasburicase.
Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Ter
CT
Chao
Chih-Kang
CK
Chiang
D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015275:Tumor Lysis Syndrome / Q000209:etiology; D014503:Urate Oxidase / Q000627:therapeutic use*
D006074:Gout Suppressants; C469709:rasburicase; D014503:Urate Oxidase