Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension.
The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.
Department of Regional Medicine, Tottori University Faculty of Medicine, Yonago, Japan. thammer@chukai.ne.jp
Toshihiro
T
Hamada
Kensaku
K
Yamada
Einosuke
E
Mizuta
Arisa
A
Watanabe
Tomohiro
T
Osaki
Katsunori
K
Ishida
Akira
A
Hasegawa
Shinji
S
Sakata
Mutsuo
M
Mishima
Kazuhide
K
Ogino
Yoshihito
Y
Nosaka
Satoshi
S
Miyazaki
Akira
A
Ohtahara
Haruaki
H
Ninomiya
Masahiko
M
Kato
Akio
A
Yoshida
Shin-ichi
S
Taniguchi
Kazuhiro
K
Yamamoto
Ichiro
I
Hisatome
D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004095:Dihydropyridines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000652:urine*; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D017311:Amlodipine; D014527:Uric Acid; D009569:Nitric Oxide; C065927:cilnidipine