The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice.
The reactivating and therapeutic efficacy of two combinations ofoximes (HI-6 + trimedoxime and HI-6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI-6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain. Moreover, both combinations of oximes were found to be slightly more efficacious in the reduction of acute lethal toxic effects in cyclosarin-poisoned mice than the antidotal treatment involving single oxime. Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings a beneficial effect for its ability to counteract the acute poisoning with cyclosarin.
University of Defence, Faculty of Military Health Sciences, Hradec Králové, Czech Republic. kassa@pmfhk.cz
Jirí
J
Kassa
Jana Zdarová
JZ
Karasová
Růzena
R
Pavlíková
Filip
F
Caisberger
Jirí
J
Bajgar
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014289:Trimedoxime / Q000627:therapeutic use
C524716:1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene; D000931:Antidotes; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D014289:Trimedoxime; C022870:asoxime chloride; C053914:cyclohexyl methylphosphonofluoridate