What have we learned from CONFIRM? Prognostic implications from a prospective multicenter international observational cohort study of consecutive patients undergoing coronary computed tomographic angiography.
Coronary computed tomographic angiography (CCTA) employing CT scanners of 64-detector rows or greater represents a novel non-invasive method for detection of coronary artery disease (CAD), providing excellent diagnostic information when compared to invasive angiography. In addition to its high diagnostic performance, prior studies have shown that CCTA can provide important prognostic information, although these prior studies have been generally limited to small cohorts at single centers. The Coronary CT Angiography EVALUATION FOR CLINICAL OUTCOMES: An International Multicenter registry, or CONFIRM, is a large, prospective, multinational, dynamic observational cohort study of patients undergoing CCTA. This registry currently represents more than 32,000 consecutive adults suspected of having CAD who underwent ≥ 64-detector row CCTA at 12 centers in 6 countries between 2005 and 2009. Based on its large sample size and adequate statistical power, the data derived from CONFIRM registry have and will continue to provide key answers to many important topics regarding CCTA. Based on its multisite international national design, the results derived from CONFIRM should be considered as more generalizable than prior smaller single-center studies. This article summarizes the current status of several studies from CONFIRM registry.
Department of Imaging and Medicine, Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yuka
Y
Otaki
Reza
R
Arsanjani
Heidi
H
Gransar
Victor Y
VY
Cheng
Damini
D
Dey
Troy
T
Labounty
Fay Y
FY
Lin
Stephan
S
Achenbach
Mouaz
M
Al-Mallah
Matthew J
MJ
Budoff
Filippo
F
Cademartiri
Tracy Q
TQ
Callister
Hyuk-Jae
HJ
Chang
Kavitha
K
Chinnaiyan
Benjamin J W
BJ
Chow
Augustin
A
Delago
Martin
M
Hadamitzky
Joerg
J
Hausleiter
Philipp
P
Kaufmann
Erica
E
Maffei
Gilbert
G
Raff
Leslee J
LJ
Shaw
Todd C
TC
Villines
Allison
A
Dunning
Ricardo C
RC
Cury
Gudrun
G
Feuchtner
Yong-Jin
YJ
Kim
Jonathon
J
Leipsic
Daniel S
DS
Berman
James K
JK
Min
D000328:Adult; D000368:Aged; D000465:Algorithms; D000792:Angiography / Q000379:methods; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012306:Risk; D012737:Sex Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016277:Ventricular Function, Left / Q000502:physiology