[Ultrastructural changes in cells of mycobacteria affected by flurenizid derivatives].
In cells of micobacteria of all investigated samples the following ultrastructural changes were observed: disorganization of a nucleoid and citoplasm, formation of the citoplasmic vacuoles and endocellular lipide-like inclusions, and also change of the cells form into spheroid and formeless mass, disappearance of periplasmatic space, occurrence of cells of small-size and short incompletely divided cells in the samples. They were observed more often after 72 hours of exposition of the cultures with antibacterial substances, than after 24 hours of exposition. The highest concentration of these substances being used, the ultrastructural changes were more essential. No significant difference between the nature of changes in the structure of cells studied using antibacterial substances has been found.
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D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D048430:Cell Shape / Q000187:drug effects; D003470:Culture Media; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D009163:Mycobacterium bovis / Q000187:drug effects* / Q000648:ultrastructure; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000648:ultrastructure; D019897:Periplasm / Q000187:drug effects / Q000648:ultrastructure; D012492:Salts / Q000737:chemistry; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
D000995:Antitubercular Agents; D003470:Culture Media; D006571:Heterocyclic Compounds; D012492:Salts; C065925:flurenizid