Ultrasonic treatment of canine ORNM.
OBJECTIVE
To investigate the effect of low-intensity ultrasound on mandibular osteoradionecrosis.


METHODS
Using a canine model, radiotherapy was delivered to the mandible at doses of 25 and 28 Gy. The microstructure of the mandible and changes in microvascular density in the low-intensity ultrasound treatment (group A) and nontreatment (group B) groups were determined and compared with those of the control group.


RESULTS
At a single dose of 28 Gy, the canines developed epilation of the mandibular skin, ulcers, and small pieces of oral sequestered material. The microvascular density in group A was significantly greater than that in group B (P<.05). Most osteocytes in group B had disappeared, with atrophy of the cancellous bone trabeculae. In contrast, in group A, a substantial amount of bone had been formed, with increasing amounts of bone trabeculae and a large number of osteoblasts.


CONCLUSIONS
Low-intensity ultrasound effectively improves the healing of irradiated bone.
Department of Stomatology, Jinan General Military Hospital, Jinan, China.
Gaoyi
G
Wu
Lei
L
Chen
Tiejun
T
Qu
Guoxiong
G
Zhu
Yanliang
Y
Wang
Chunsheng
C
Zhu
D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D005260:Female; D008297:Male; D008334:Mandible / Q000098:blood supply / Q000000981:diagnostic imaging; D008336:Mandibular Diseases / Q000628:therapy*; D023421:Models, Animal; D010025:Osteoradionecrosis / Q000628:therapy*; D036542:Tomography, Spiral Computed; D014464:Ultrasonic Therapy / Q000379:methods; D055114:X-Ray Microtomography