[The experimental evaluation of antiradiation effectiveness of beta-estradiol on survival rates and bone marrow hemopoiesis of X-ray irradiated mice].
The study was aimed at evaluating the radioprotective effectiveness of beta-estradiol following its prophylactic administration in conditions of acute irradiation. Evaluation of the radioprotective efficiency was performed by studying the 30-day survival rate, life expectancy, the structure of irradiated mice death, the bone marrow hematopoiesis using the method of exogenous colony formation. The prophylactic use of beta-estradiol at doses of 20 and 40 mg/kg 5 days before irradiation has been established to protect the exposed mice against radiation death induced by X-rays at doses LD50-90/30, thus increasing their survival rate by 17-58%, and to favor the reduced expression of post radiation disorders of bone marrow hematopoiesis.
A N
AN
Grebeniuk
V N
VN
Bykov
V A
VA
Miasnikov
V V
VV
Zatsepin
N V
NV
Aksenova
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects*; D004958:Estradiol / Q000008:administration & dosage*; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D015996:Survival Rate; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects
D011837:Radiation-Protective Agents; D004958:Estradiol