Molecular characterization of a new D- - haplotype in a Comorian man.
The D- - phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D- - phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice-site changes. This article reports the identification of a new D- - haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 3-8 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen.
Établissement Français du Sang Alpes Méditerranée, Laboratoire d'Hématologie Moléculaire, UMR 7268, Aix-Marseille Université, France.
M
M
Silvy
S
S
Chapel-Fernandes
S
S
Beley
C
C
Durousseau
T
T
Granier
J P
JP
Zappitelli
P
P
Bailly
J
J
Chiaroni
D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology; D017507:Comoros; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D008297:Male; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics* / Q000276:immunology
D001789:Blood Group Antigens; D000939:Epitopes; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen