Bioactive sesquiterpenoids from the rhizomes of Acorus calamus.
Eight new sesquiterpenes (1-8) and one new norsesquiterpene (9) named calamusins A-I were isolated from the ethanol extract of Acorus calamus rhizomes. The absolute configuration of compound 8 was determined by comparing its experimental and calculated ECD spectra. The absolute configurations of the other compounds were determined from their CD spectra. Furthermore, in in vitro assays, compounds 3, 4, 7, and 9 (10 μM) exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Zhi-You
ZY
Hao
Dong
D
Liang
Huan
H
Luo
Yan-Fei
YF
Liu
Gang
G
Ni
Qing-Jian
QJ
Zhang
Li
L
Li
Yi-Kang
YK
Si
Hua
H
Sun
Ruo-Yun
RY
Chen
De-Quan
DQ
Yu
D000082:Acetaminophen / Q000494:pharmacology; D029023:Acorus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D000082:Acetaminophen