Magnetoencephalography in pediatric lesional epilepsy surgery.
This study was performed to assess the usefulness of magnetoencephalography (MEG) as a presurgical evaluation modality in Korean pediatric patients with lesional localization-related epilepsy. The medical records and MEG findings of 13 pediatric patients (6 boys and 7 girls) with localization-related epilepsy, who underwent epilepsy surgery at Seoul National University Children's Hospital, were retrospectively reviewed. The hemispheric concordance rate was 100% (13/13 patients). The lobar or regional concordance rate was 77% (10/13 patients). In most cases, the MEG spike sources were clustered in the proximity of the lesion, either at one side of the margin (nine patients) or around the lesion (one patient); clustered spike sources were distant from the lesion in one patient. Among the patients with clustered spike sources near the lesion, further extensions (three patients) and distal scatters (three patients) were also observed. MEG spike sources were well lateralized and localized even in two patients without focal epileptiform discharges in the interictal scalp electroencephalography. Ten patients (77%) achieved Engel class I postsurgical seizure outcome. It is suggested that MEG is a safe and useful presurgical evaluation modality in pediatric patients with lesion localization-related epilepsy.
Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Hunmin
H
Kim
Byung Chan
BC
Lim
Woorim
W
Jeong
June Sic
JS
Kim
Jong-Hee
JH
Chae
Ki Joong
KJ
Kim
Chun Kee
CK
Chung
Yong Seung
YS
Hwang
Hee
H
Hwang
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000473:pathology / Q000601:surgery*; D004827:Epilepsy; D005260:Female; D018303:Ganglioglioma / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D054220:Malformations of Cortical Development / Q000473:pathology; D065703:Malformations of Cortical Development, Group I; D018302:Neoplasms, Neuroepithelial / Q000473:pathology; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis