[Mechanisms of self-regulation of myocardial contractile function during hypokinesia and muscle training].
This article analyzes the literature devoted to the role of the myocardial contractile apparatus in the regulation of cardiac pump function during hypokinesia, moderate and excessive physical exercises. These data indicate that moderate exercises increase the role of myocardial contractile apparatus, thereby efficiency of cardiac and extracardiac mechanisms for its regulation increase. Excessive loads increase adrenergic inotropic effects on the myocardium in combination with a reduction of the contribution of its contractile apparatus in a common set of regulatory influences on cardiac pump function. Weakening of self regulation mechanisms is typical for the regime of hypokinesia also. However, in the latter case the enhancement of adrenergic inotropic effects is absent.
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Chinkin
D000222:Adaptation, Physiological; D001810:Blood Volume / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology; D009132:Muscles / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*