The relationship of periodontal disease severity to serum and GCF substance P levels in diabetics.
OBJECTIVE
To compare circulating and gingival crevicular fluid (GCF) substance P concentrations in well- and poorly controlled type 2 diabetic patients with chronic periodontitis.


METHODS
Forty-five serum and 90 GCF samples were collected from diabetic patients with periodontal disease, and the concentrations of substance P were quantified by radioimmunoassay.


RESULTS
Serum substance P levels were higher in the poorly controlled diabetic group than in patients with good glycemic control (P = .01); within the poorly controlled group, patients with severe attachment levels had the highest circulating substance P levels (P = .02). Additionally, the diseased sites showed higher substance P levels than control sites (P = .0016). The GCF substance P concentrations in diseased sites correlated significantly with clinical findings such as Plaque Index (r = 0.51, P = .001) and bleeding on probing (r = 0.35, P = .029).


CONCLUSIONS
Within the limits of this study, our preliminary findings indicate that periodontal inflammation may influence circulating and GCF substance P levels in poorly controlled diabetic subjects.
Department of Periodontology, Ondokuz Mayis University, Samsun, Turkey. aylao@omu.edu.tr
Ayla
A
Ozturk
Birşen
B
Bilgici
Selcen
S
Odyakmaz
Elif
E
Konas
D000328:Adult; D000368:Aged; D055113:Chronic Periodontitis / Q000150:complications* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020078:Neurogenic Inflammation; D012907:Smoking / Q000378:metabolism; D013373:Substance P / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
D006442:Glycated Hemoglobin; D013373:Substance P