Neurocysticercosis case with tuberculoma-like epithelioid granuloma strongly suspected by serology and confirmed by mitochondrial DNA.
An Indian woman with multiple and nodular cerebral lesions presenting epithelioid granulomas was diagnosed as suspected malignant tumours and the biopsy was carried at local hospital in Japan. The specimen was pathologically diagnosed as tuberculoma. However, due to her nationality, the authors suspected it to be neurocysticercosis (NCC) and carried out serology and applied mitochondrial DNA analysis of Taenia solium. These diagnostic tools revealed it as NCC radiologically and pathologically mimicking central nervous tuberculomas. Molecular confirmation of NCC cases is strongly recommended when we can get the biopsy specimens.
Division of Infectious Diseases and Pulmonary Medicine, Department on Internal Medicine 2, National Defense Medical College, Tokorozawa, Saitama, Japan. tmaeda@ndmc.ac.jp
Takuya
T
Maeda
Akira
A
Ito
Yasuhito
Y
Sako
Hiroshi
H
Yamasaki
Naoki
N
Oyaizu
Takashi
T
Odawara
Aikichi
A
Iwamoto
Takeshi
T
Fujii
D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001706:Biopsy; D003287:Contrast Media; D004272:DNA, Mitochondrial / Q000032:analysis*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D020019:Neurocysticercosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D059906:Neuroimaging; D041201:Taenia solium; D016862:Tuberculoma, Intracranial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D000871:Anthelmintics; D003287:Contrast Media; D004272:DNA, Mitochondrial; D015766:Albendazole