The syntheses and characterizations of molybdenum(VI) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities.
The reactions of (NH(4))(2)Mo(2)O(7)·2H(2)O with polyhydroxy phenols (catechol or 2,3-dihydroxynaphthalene) and ethylenediamine (en), trimethylenediamine (tn), 1,2-propanediamine (pn), triethylamine (Et(3)N) respectively, in the mixed-solvent of MeCN-EtOH-amine, have resulted in five molybdenum(VI) complexes, (enH(2))[Mo(VI)O(3)(cat)(en)] (1), (tnH(2))[Mo(VI)O(3)(cat)(tn)] (2), (enH)(2)[Mo(VI)O(2)(cat)(2)](en)(0.5) (3), (pnH(2))(2)[Mo(VI)O(2)(cat)(2)] (4) and (HNEt(3))(2)[Mo(VI)O(2)(C(10)H(8)O(2))(2)] (5), of which the structural features were investigated by X-ray diffraction. MTT assay tests indicated that their inhibition ratios against human cancer cells decreased in the order: (1) ≈ (2) > (3) ≈ (4) > (5), i.e. the activities decreased when the chelation number or the size of the aromatic ligand increased, which was consistent with the Gibbs free energies (ΔG) determined from theoretical computations by Gaussian 03. The mechanisms behind this trend were discussed preliminarily.
Department of Chemistry, Capital Normal University, Beijing, 100037, China.
Jun
J
Feng
Xiao-ming
XM
Lu
Guo
G
Wang
Shi-zhen
SZ
Du
Yi-feng
YF
Cheng
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002396:Catechols / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry* / Q000494:pharmacology; D009284:Naphthols / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002396:Catechols; D009284:Naphthols; D009942:Organometallic Compounds; D008982:Molybdenum; C034221:catechol; C053499:2,3-dihydroxynaphthalene