TRAIL as biomarker and potential therapeutic tool for cardiovascular diseases.
This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.
Department of Morphology and Embriology, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy.
Stella
S
Bernardi
Daniela
D
Milani
Bruno
B
Fabris
Paola
P
Secchiero
Giorgio
G
Zauli
D015415:Biomarkers / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
D015415:Biomarkers; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human