[Perspectives on pharmacological and clinical benefits from sirtuin 1 activators in oxidative damage].
Sirtuins, named after their homology to the Saccharomyces cerevisiae Silent Information Regulator Two, constitute a family of highly conserved nicotinamide adenine dinucleotide-dependent enzymes that deacetylate histones and residues of acetylated lysine. The main aim of this article is to put forward the pharmacological importance of major sirtuin 1 activators of natural or synthetic origin tested in last years in cases of oxidative tissue damage. The related bioactivity of these activators as "leading" compounds in the search for new drugs and remedies is also described. With the recent development of our knowledge on the cross talks between sirtuin 1 and its modulators (e.g. resveratrol), pharmacological and clinical research on this topic is getting a new horizon.
Karlova Univerzita v Praze, 1. lékarská fakulta, Farmakologický ustav. ncano@lf1.cuni.cz
Canová Nikolina
CN
Kutinová
Norbert
N
Gaier
Hassan
H
Farghali
D000975:Antioxidants / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D056564:Sirtuin 1 / Q000502:physiology*
D000975:Antioxidants; D056564:Sirtuin 1