Bioavailable vitamin D in chronic kidney disease.
Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.
Washington University School of Medicine, St Louis, Missouri 63110, USA.
Alex J
AJ
Brown
Daniel W
DW
Coyne
D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D006435:Renal Dialysis; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*
D014807:Vitamin D; C104450:25-hydroxyvitamin D