Preclinical evaluation of an MRI-compatible pneumatic robot for angulated needle placement in transperineal prostate interventions.
OBJECTIVE
To evaluate the targeting accuracy of a small profile MRI-compatible pneumatic robot for needle placement that can angulate a needle insertion path into a large accessible target volume.


METHODS
We extended our MRI-compatible pneumatic robot for needle placement to utilize its four degrees-of-freedom (4-DOF) mechanism with two parallel triangular structures and support transperineal prostate biopsies in a closed-bore magnetic resonance imaging (MRI) scanner. The robot is designed to guide a needle toward a lesion so that a radiologist can manually insert it in the bore. The robot is integrated with navigation software that allows an operator to plan angulated needle insertion by selecting a target and an entry point. The targeting error was evaluated while the angle between the needle insertion path and the static magnetic field was between -5.7° and 5.7° horizontally and between -5.7° and 4.3° vertically in the MRI scanner after sterilizing and draping the device.


RESULTS
The robot positioned the needle for angulated insertion as specified on the navigation software with overall targeting error of 0.8 ± 0.5mm along the horizontal axis and 0.8 ± 0.8mm along the vertical axis. The two-dimensional root-mean-square targeting error on the axial slices as containing the targets was 1.4mm.


CONCLUSIONS
Our preclinical evaluation demonstrated that the MRI-compatible pneumatic robot for needle placement with the capability to angulate the needle insertion path provides targeting accuracy feasible for clinical MRI-guided prostate interventions. The clinical feasibility has to be established in a clinical study.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. tokuda@bwh.harvard.edu
Junichi
J
Tokuda
Sang-Eun
SE
Song
Gregory S
GS
Fischer
Iulian I
II
Iordachita
Reza
R
Seifabadi
Nathan B
NB
Cho
Kemal
K
Tuncali
Gabor
G
Fichtinger
Clare M
CM
Tempany
Nobuhiko
N
Hata
D001707:Biopsy, Needle; D001918:Brachytherapy; D002138:Calibration; D004867:Equipment Design; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D010502:Perineum; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D012371:Robotics / Q000295:instrumentation*; D012984:Software