Cholinesterase-responsive supramolecular vesicle.
Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using "superamphiphiles", provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer's disease, and therefore, the present system may have potential for the delivery of Alzheimer's disease drugs.
Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Dong-Sheng
DS
Guo
Kui
K
Wang
Yi-Xuan
YX
Wang
Yu
Y
Liu
D047250:Calixarenes / Q000737:chemistry / Q000378:metabolism*; D002460:Cell Line; D002794:Choline / Q000031:analogs & derivatives / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000378:metabolism*
D003692:Delayed-Action Preparations; D047028:Macrocyclic Compounds; D010636:Phenols; C511968:p-sulfonatocalix(4)arene; D047250:Calixarenes; D002802:Cholinesterases; D002794:Choline