Basal and postprandial serum levels of gastrin in normotensive and hypertensive adults.
Gastrin is a peptide hormone, which acts not only to regulate gastric acid secretion, but also to exert physiological actions such as the regulation of sodium balance. From a case (n = 95)-control (n = 82) study in Fuyang People's Hospital, Anhui Province, China, we found that the fasting serum gastrin levels are similar in normotensive and hypertensive adults but increased to higher levels in the latter group than in the former group after a mixed meal. We suggest that gastrin is involved in the regulation of blood pressure, possibly via the regulation of sodium and water metabolism and/or renin-angiotensin-aldosterone system. However, the mechanism remains to be determined.
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Centre, Peking Union Medical College, Beijing, PR China.
Xiaoliang
X
Jiang
Wenjie
W
Wang
Bin
B
Ning
Xing
X
Liu
Jian
J
Gong
Fusheng
F
Gan
Xuezhong
X
Gao
Lianfeng
L
Zhang
Pedro A
PA
Jose
Chuan
C
Qin
Zhiwei
Z
Yang
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D005215:Fasting / Q000097:blood; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D019518:Postprandial Period / Q000502:physiology; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D005755:Gastrins; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin