HDX workbench: software for the analysis of H/D exchange MS data.
Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page                             http://hdx.florida.scripps.edu                                                     .
Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL 33458, USA.
Bruce D
BD
Pascal
Scooter
S
Willis
Janelle L
JL
Lauer
Rachelle R
RR
Landgraf
Graham M
GM
West
David
D
Marciano
Scott
S
Novick
Devrishi
D
Goswami
Michael J
MJ
Chalmers
Patrick R
PR
Griffin
D000465:Algorithms; D000595:Amino Acid Sequence; D041961:Deuterium Exchange Measurement / Q000379:methods*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D015203:Reproducibility of Results; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D012984:Software; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014584:User-Computer Interface
D010455:Peptides; D011506:Proteins