Mechanisms of developmental robustness.
We present a review of noise buffering mechanisms responsible for developmental robustness. We focus on functions of chaperone Hsp90, miRNA, and cross-regulation of gap genes in Drosophila. The noise buffering mechanisms associated with these functions represent specific examples of the developmental canalization, reducing the phenotypical variability in presence of either genetic or environmental perturbations. We demonstrate that robustness often appears as a function of a network of interacting elements and that the system level approach is needed to understand the mechanisms of noise filtering.
Theoretical Department, Ioffe Physical-Technical Institute of the Russian Academy of Sciences, St. Petersburg, 194021, Russia. gursky@math.ioffe.ru
Vitaly V
VV
Gursky
Svetlana Yu
SY
Surkova
Maria G
MG
Samsonova
D000818:Animals; D004330:Drosophila / Q000196:embryology*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*
D020690:GTPase-Activating Proteins; D018841:HSP90 Heat-Shock Proteins; D035683:MicroRNAs