Lasionectrin, a naphthopyrone from a Lasionectria sp.
A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, E-18100 Armilla, Granada, Spain.
Noureddine
N
El Aouad
Guiomar
G
Pérez-Moreno
Paula
P
Sánchez
Juan
J
Cantizani
Francisco Javier
FJ
Ortiz-López
Jesús
J
Martín
Víctor
V
González-Menéndez
Luis M
LM
Ruiz-Pérez
Dolores
D
González-Pacanowska
Francisca
F
Vicente
Gerald
G
Bills
Fernando
F
Reyes
D000962:Antimalarials / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016703:Equatorial Guinea; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000382:microbiology; D010963:Plasmodium falciparum / Q000187:drug effects; D011753:Pyrones / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000962:Antimalarials; D009281:Naphthalenes; D011753:Pyrones; C575019:lasionectrin