Runt-related transcription factor 3 methylation as a possible prognosticator in muscle-invasive bladder cancer.
This study sought to determine if runt-related transcription factor 3 (RUNX3) methylation could accurately predict the overall survival in patients with muscle invasive bladder cancer (MIBC). Forty-seven patients with a longer followup period (cohort 1; reported previously) were analyzed. Tumor samples (cohort 2; newly collected) were obtained from 139 MIBC patients. The prognostic significance of RUNX3 methylation was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. RUNX3 methylation affected the overall survival in cohort 1 (log-rank test; P=0.030). Among the patients in cohort 2, RUNX3 promoter methylation was observed in 93 of the 139 tumor samples (66.9%). Kaplan-Meier estimates showed a significant difference in overall survival according to RUNX3 methylation (P=0.020). By multivariate Cox regression analysis, positive RUNX3 methylation was an independent predictor of overall survival. These results suggest that RUNX3 promoter methylation is a significant prognostic factor for overall survival in MIBC patients.
Department of Urology, College of Medicine School of Medicine, Chungbuk National University, Cheongju, Korea.
Pildu
P
Jeong
Yun-Sok
YS
Ha
Ji Sang
JS
Kim
In-Chang
IC
Cho
Won Tae
WT
Kim
Yong-June
YJ
Kim
Isaac
I
Yi Kim
Seok-Joong
SJ
Yun
Sang-Cheol
SC
Lee
Eun-Jong
EJ
Cha
Wun-Jae
WJ
Kim
D000368:Aged; D015331:Cohort Studies; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics*; D019175:DNA Methylation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D011401:Promoter Regions, Genetic; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000628:therapy
D050677:Core Binding Factor Alpha 3 Subunit