MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7.
Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR-26, an LXR-suppressed miRNA, inhibits the expression of the ATP-binding cassette transporter A1 (ABCA1) and ADP-ribosylation factor-like 7 (ARL7), two LXR target genes which play critical roles in cholesterol efflux. These findings have not only figured out an alternative mechanism for LXR regulation, but also provided a potential therapeutic target for cholesterol metabolic disorders.
Department of Geriatrics, Zhejiang Provincial People's Hospital, Hangzhou, PR China.
Dongsheng
D
Sun
Jun
J
Zhang
Jianhong
J
Xie
Wei
W
Wei
Mantao
M
Chen
Xiang
X
Zhao
D020413:3' Untranslated Regions; D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D001692:Biological Transport; D002460:Cell Line; D002784:Cholesterol / Q000378:metabolism*; D017931:DNA Primers; D000071518:Liver X Receptors; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D057093:Orphan Nuclear Receptors / Q000502:physiology*; D014158:Transcription, Genetic
D020413:3' Untranslated Regions; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; C573666:Arl4c protein, mouse; D017931:DNA Primers; D000071518:Liver X Receptors; D035683:MicroRNAs; C543693:Mirn26 microRNA, mouse; D057093:Orphan Nuclear Receptors; D002784:Cholesterol; D020727:ADP-Ribosylation Factors