Decline in semicircular canal and otolith function with age.
OBJECTIVE
To characterize the physiologic nature of the vestibular dysfunction that occurs with the normative aging process.


METHODS
Cross-sectional study.


METHODS
Tertiary care academic medical center.


METHODS
Fifty individuals age 70 years and above.


METHODS
Head thrust dynamic visual acuity testing and cervical and ocular vestibular-evoked myogenic potential (VEMP) testing.


METHODS
Semicircular canal function measured by head thrust dynamic visual acuity testing in each of the 3 semicircular canal planes, and saccular and utricular function measured by cervical VEMP and ocular VEMP testing, respectively.


RESULTS
We observed significant declines in semicircular canal function in each of the canal planes as well as otolith function associated with aging. We found that individuals with impaired horizontal and superior semicircular canal function also were likely to have concomitant deficits in utricular but not saccular function. Overall, we noted that the prevalence of semicircular canal dysfunction was highest followed by saccular then utricular impairment, although we did observe individuals with isolated otolith deficits.


CONCLUSIONS
These data suggest an overall decline in semicircular canal as well as otolith function associated with aging, although the magnitude of impairment was greater for the semicircular canals than the otoliths in this elderly population. A better understanding of the specific vestibular deficits that occur with aging can inform the development of rational screening, vestibular rehabilitation, and fall risk reduction strategies in older individuals.
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. yagrawa1@jhmi.edu
Yuri
Y
Agrawal
Maria Geraldine
MG
Zuniga
Marcela
M
Davalos-Bichara
Michael C
MC
Schubert
Jeremy D
JD
Walston
Jennifer
J
Hughes
John P
JP
Carey
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D010037:Otolithic Membrane / Q000502:physiology*; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D012665:Semicircular Canals / Q000502:physiology*; D058585:Vestibular Evoked Myogenic Potentials / Q000502:physiology; D014724:Vestibular Function Tests