Massive calcium channel blocker overdose: intravenous insulin and glucose as a therapy.
We describe a case of massive overdosage with cardiac medications that proved resistant to conventional support, including fluid replacement, inotropes, mechanical ventilation, cardiac pacing and haemofiltration. The use of a high-dose insulin and glucose infusion proved to be beneficial in the acute management although the patient has been left with significant impairment of cardiac function.
Department of Cardiology, Hillingdon Hospital, Uxbridge, Middlesex, UK.
Gareth
G
Rosser
Simon William
SW
Dubrey
D000328:Adult; D002121:Calcium Channel Blockers / Q000506:poisoning*; D062787:Drug Overdose / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006946:Hyperinsulinism / Q000139:chemically induced* / Q000188:drug therapy; D006973:Hypertension / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose