Mitochondrial metabolism - neglected link of cancer transformation and treatment.
Physical processes in living cells were not taken into consideration             among the essentials of biological activity, regardless of the fact that they establish             a state far from thermodynamic equilibrium. In biological system chemical energy             is transformed into the work of physical forces for various biological functions.             The energy transformation pathway is very likely connected with generation             of the endogenous electrodynamic field as suggested by experimentally proved             electrodynamic activity of biological systems connected with mitochondrial             and microtubule functions. Besides production of ATP and GTP (adenosine             and guanosine triphosphate) mitochondria form a proton space charge layer,             strong static electric field, and water ordering around them in cytosol - that             are necessary conditions for generation of coherent electrodynamic field by             microtubules. Electrodynamic forces are of a long-range nature in comparison             with bond and cohesive forces. Mitochondrial dysfunction leads to disturbances             of the electromagnetic field; its power and coherence may be diminished, and             frequency spectrum altered. Consequently, defective electrodynamic interaction             forces between cancer and healthy cells may result in local invasion of cancer cells.             Further deformation of interaction forces connected with experimentally disclosed             spatial disarrangement of the cytoskeleton and disordered electrodynamic field             condition metastatic process. Cancer therapeutic strategy targeting mitochondria             may restore normal physiological functions of mitochondria and open the             apoptotic pathway. Apoptosis of too much damaged cancer cells was observed.             Considerable experience with DCA (dichloroacetate) cancer treatment in humans             was accumulated. Clinical trials should assess DCA therapeutic potential and collect             data for development of novel more effective drugs for mitochondrial restoration of             various cancers.
Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
J
J
Pokorný
A
A
Jandová
M
M
Nedbalová
F
F
Jelínek
M
M
Cifra
O
O
Kučera
D
D
Havelka
J
J
Vrba
J
J
Vrba
A
A
Coček
J
J
Kobilková
D000255:Adenosine Triphosphate / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003999:Dichloroacetic Acid / Q000627:therapeutic use; D055724:Electrophysiological Phenomena; D004734:Energy Metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D003999:Dichloroacetic Acid