Angiographically-assessed coronary artery disease associates with HDL particle size in women.
It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects.


OBJECTIVE
To investigate, in women, the relationship between HDL particle size and coronary artery disease (CAD).


METHODS
Average HDL particle size was measured in a sample of 239 women on whom CAD was assessed by angiography.


RESULTS
Overall, women who had CAD were characterized by a deteriorated fasting metabolic risk profile, which was accompanied by smaller HDL particles compared to women without CAD (80.4 ± 2.2 Å vs. 81.5 ± 2.7 Å, p < 0.01). In addition, a reduced HDL particle size was a significant correlate of several features of the atherogenic metabolic profile of abdominal obesity such as increased triglyceride and apolipoprotein B concentrations, decreased HDL cholesterol levels, an elevated cholesterol/HDL cholesterol ratio and hyperinsulinemia and was also associated with an increased waist circumference (0.13≤|r|≤0.21, p < 0.05). Odds ratio of being affected by CAD was increased by 2.5-fold (95% CI: 1.4-4.5; p < 0.01) among women with smaller HDL particles compared to women with larger HDL particles. Finally, women characterized by the presence of the NCEP-ATP III clinical criteria or by hypertriglyceridemic waist were characterized by smaller HDL particles compared to women without these clinical phenotypes (p < 0.05).


CONCLUSIONS
HDL particle size appears to be another relevant feature of a dysmetabolic state which is related to CAD risk in women.
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec (Québec), Canada.
Patricia
P
Blackburn
Isabelle
I
Lemieux
Benoît
B
Lamarche
Jean
J
Bergeron
Patrice
P
Perron
Gérald
G
Tremblay
Daniel
D
Gaudet
Jean-Pierre
JP
Després
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004586:Electrophoresis; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood*; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000175:diagnosis / Q000453:epidemiology; D016017:Odds Ratio; D010316:Particle Size; D010641:Phenotype; D011237:Predictive Value of Tests; D011792:Quebec / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D055105:Waist Circumference
D015415:Biomarkers; D008075:Lipoproteins, HDL