[Comments on the pathogenesis of Behçet's disease. A key to understanding new therapies?].
The etiology and pathogenesis of Behçet's syndrome remains unclear. It has been postulated that an infectious agent may induce an immune-mediated, generalized vasculitis in genetically predisposed individuals (HLA-B51 +). There is accumulating evidence that an abnormality of the innate and adaptive immune response, e.g. directed against heat shock proteins plays an important role in Behçet's syndrome. This article is intended to evaluate the more recent knowledge on this disorder and evaluate new therapeutic options.
Augenklinik, Uveitis Zentrum, Charité Universitätsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland. uwe.pleyer@charite.de
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Pleyer
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Hazirolan
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Stübiger
D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D018448:Models, Immunological
D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents