Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.
A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
Centre for Research in Environmental Epidemiology, Barcelona, Spain. mbustamante@creal.cat
M
M
Bustamante
A
A
Danileviciute
A
A
Espinosa
J R
JR
Gonzalez
I
I
Subirana
S
S
Cordier
C
C
Chevrier
L
L
Chatzi
R
R
Grazuleviciene
J
J
Sunyer
J
J
Ibarluzea
F
F
Ballester
C M
CM
Villanueva
M
M
Nieuwenhuijsen
X
X
Estivill
M
M
Kogevinas
D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D005333:Fetus / Q000201:enzymology*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000235:genetics*
D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase; C491107:GSTT2 protein, human