Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowers.
We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 μg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 μg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
Laboratoire des Maladies Transmissibles et des Substances Biologiquement Actives, Faculté de Pharmacie, Monastir 5000, Tunisia.
Hayet
H
Edziri
Maha
M
Mastouri
Mohamed Ali
MA
Mahjoub
Zine
Z
Mighri
Aouni
A
Mahjoub
Luc
L
Verschaeve
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D000935:Antifungal Agents / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000494:pharmacology* / Q000633:toxicity; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D035264:Flowers / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047309:Flavones; D005419:Flavonoids; D010936:Plant Extracts; C575324:derrone; C533963:licoflavone C