Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate.
Carboxylesterase 1 is the enzyme involved in methylphenidate (MPH) metabolism. The aim of this study was to evaluate the association between a -75 T>G polymorphism and appetite reduction in children with attention-deficit/hyperactivity disorder (ADHD). A sample of 213 children with ADHD was investigated. The primary outcome was appetite reduction measured by the Barkley Stimulant Side Effect Rating Scale applied at baseline, at 1 and 3 months of treatment. MPH doses were augmented until no further clinical improvement or significant adverse events occurred. The G allele presented a trend for association with appetite reduction scores (P=0.05). A significant interaction between the G allele and treatment over time for appetite reduction scores was also observed (P=0.03). The G allele carriers presented a higher risk for appetite reduction worsening when compared with T allele homozygotes (odds ratio=3.47, P=0.01). The present results suggest an influence of carboxylesterase 1 -75 T>G polymorphism on the worsening of appetite reduction with MPH treatment in youths with ADHD.
Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
E M
EM
Bruxel
A
A
Salatino-Oliveira
J P
JP
Genro
C P
CP
Zeni
G V
GV
Polanczyk
R
R
Chazan
L A
LA
Rohde
M H
MH
Hutz
D000293:Adolescent; D000483:Alleles; D001066:Appetite / Q000187:drug effects / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000235:genetics*; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002648:Child; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D011110:Polymorphism, Genetic
D008774:Methylphenidate; D002265:Carboxylic Ester Hydrolases; C474609:CES1 protein, human