Genomics screens for metastasis genes.
Metastasis is responsible for most cancer mortality. The process of metastasis is complex, requiring the coordinated expression and fine regulation of many genes in multiple pathways in both the tumor and host tissues. Identification and characterization of the genetic programs that regulate metastasis is critical to understanding the metastatic process and discovering molecular targets for the prevention and treatment of metastasis. Genomic approaches and functional genomic analyses can systemically discover metastasis genes. In this review, we summarize the genetic tools and methods that have been used to identify and characterize the genes that play critical roles in metastasis.
University of Washington Medical Center, 1959 N. E. Pacific Street, Seattle, WA 98195, USA. jyan@u.washington.edu
Jinchun
J
Yan
Qihong
Q
Huang
D000818:Animals; D003582:Cytogenetics; D020869:Gene Expression Profiling; D015723:Gene Library; D023281:Genomics / Q000379:methods*; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D040641:Quantitative Trait Loci; D034622:RNA Interference