Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model.
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada.
Atul
A
Bhardwaj
Sri N
SN
Batchu
Jatinder
J
Kaur
Zhangjian
Z
Huang
John M
JM
Seubert
Edward E
EE
Knaus
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D004195:Disease Models, Animal; D015195:Drug Design; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000188:drug therapy*; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D007783:Lactones; D020030:Nitric Oxide Donors; D013450:Sulfones; C116926:rofecoxib; D009569:Nitric Oxide; D051546:Cyclooxygenase 2