Small-Molecule Library Synthesis on Silicon-Functionalized SynPhase Lanterns.
Silicon-functionalized SynPhase Lanterns are useful for the combinatorial synthesis of small-molecule libraries. Lanterns bearing an alkyl tethered diisopropylarylsilane are first activated with triflic acid to afford the corresponding diisopropylsilyl triflate, which is then reacted with a library scaffold bearing a free alcohol. Once the scaffold has been loaded onto the solid phase, a variety of transformations can be run, including amine cappings, cross-coupling reactions and amide bond formation. These reactions can yield a variety of products when run sequentially using split-pool synthesis strategies. Upon completion of the solid-phase transformations, the small-molecules are released from the Lanterns using HF/pyridine. Using the techniques described within, libraries can be made ranging from a few compounds to >10,000 members in a highly efficient manner.
Chemical Biology Platform, The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge Massachusetts 02142.
Jeremy R
JR
Duvall
Anita
A
Vrcic
Lisa A
LA
Marcaurelle