The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention.
BACKGROUND
The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance.


METHODS
Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2 kg/m²) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34 kcal/day) and food intake (1882±68.8 kcal/day) were tightly controlled.


RESULTS
Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33±1.3 vs -1.46±0.70, p=0.004).


CONCLUSIONS
PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.
Department of Clinical Nursing Science, Yonsei University College of Nursing, Nursing policy and Research Institute, Biobehavioral Research Center, Seoul, Korea.
Sang Hui
SH
Chu
Ji-Hye
JH
Park
Mi Kyung
MK
Lee
Yoonsuk
Y
Jekal
Ki Yong
KY
Ahn
Jae Youn
JY
Chung
Dong Hoon
DH
Lee
Eun Sung
ES
Kim
Masayo
M
Naruse
Jee-Aee
JA
Im
In Deok
ID
Kong
Deok
D
Kong
Choon Hee
CH
Chung
Ji Won
JW
Lee
Kyong-Mee
KM
Chung
Young-Bum
YB
Kim
Justin Y
JY
Jeon
D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D004435:Eating; D015444:Exercise; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
D001786:Blood Glucose; D002097:C-Reactive Protein; D007328:Insulin; D000683:Serum Amyloid P-Component; D000099153:Pentraxins