Multifaceted activities of CCR7 regulate T-cell homeostasis in health and disease.
CCR7 is a homeostatically expressed chemokine receptor that is known to regulate the homing of various types of immune cells to primary, secondary, and tertiary lymphoid organs. Recent evidence suggests that, in addition to controlling cell migration, CCR7-mediated signals affect T-cell homeostasis in lymph nodes at various levels and also influence T-cell activation and polarization. In this review, we highlight these findings and discuss recently proposed functions of the CCR7 pathway in the induction and maintenance of chronic inflammation.
Institute of Immunology, Hannover Medical School, Hannover, Germany. Moschovakis.Leandros@mh-hannover.de
Georgios Leandros
GL
Moschovakis
Reinhold
R
Förster
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D054400:Receptors, CCR7 / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology*
C515370:CCR7 protein, human; D054400:Receptors, CCR7