Efficient iodine catalyzed three components domino reaction for the synthesis of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives possessing anticancer activities.
A simple and efficient three components domino reaction of γ-butyrolactam (2-pyrrolidinone), aromatic aldehyde and substituted thiophenol catalyzed by elemental iodine resulted in the formation of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives. The stability of the synthesized analogues was evaluated in stimulated gastric fluid (SGF) and bovine serum albumin (BSA). In vitro anticancer activity was investigated in the low micromolar range and a few analogues were found to possess good activity. This current protocol provides several advantages like shorter reaction time, excellent yield and convenient work-up.
Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632014, Tamilnadu, India.
Gunasekar
G
Ramachandran
Natesan S
NS
Karthikeyan
Periyasamy
P
Giridharan
Kulathu I
KI
Sathiyanarayanan
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002384:Catalysis; D002417:Cattle; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods; D006801:Humans; D007455:Iodine / Q000737:chemistry*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000378:metabolism
D000970:Antineoplastic Agents; D011760:Pyrrolidinones; D012710:Serum Albumin, Bovine; D007455:Iodine; C028537:2-pyrrolidone