The emerging role of PEDF in stem cell biology.
Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.
Department of Biomedical and Health Sciences, Victoria University, St Albans, VIC 3021, Australia.
Mina
M
Elahy
Swati
S
Baindur-Hudson
Crispin R
CR
Dass
D000818:Animals; D003585:Cell Biology; D005136:Eye Proteins / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D015843:Serpins / Q000502:physiology*; D057905:Stem Cell Research; D013234:Stem Cells / Q000502:physiology*; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor