Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.
In this letter, we describe the first synthesis of two recently isolated flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and anticancer activities. Most of the synthesized compounds exhibited antimicrobial activity against the tested microbial strains and some of these compounds were found to be more potent as compared to the standard drugs like neomycin and luteolin. Interestingly, some of these synthesized compounds also showed moderate antioxidant property.
Division of Organic Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India. ahmedkamal@iict.res.in
Ahmed
A
Kamal
J N S R C
JN
Murty
A
A
Viswanath
P
P
Sujitha
C
C
Ganesh Kumar
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C576834:5-carboethoxymethyl-4',7-dihydroxyflavone; C576833:5-carbomethoxymethyl-7-hydroxy-2-pentylchromone; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000975:Antioxidants; D002867:Chromones; D047309:Flavones; D005419:Flavonoids; C085172:4',7-dihydroxyflavone