Dementia and diabetes mellitus: association with apolipoprotein e4 polymorphism from a hospital in southern India.
Objective. To evaluate the association of Apolipoprotein E4 (ApoE4) in Alzheimer's dementia (AD) with comorbid diabetes mellitus (DM). Methods. The study included subjects with Alzheimer's dementia (AD) (n = 209), individuals with non-Alzheimer's dementia (nAD) (n = 122), individuals with parental history of AD (f/hAD) (n = 70), and control individuals who had normal cognitive functions and no parental history of dementia (NC) (n = 193). Dementia was diagnosed using International Classification of Diseases-10 revision (ICD-10) criteria. DM was assessed on the basis of self-report and/or use of antidiabetic medications. ApoE genotyping was done using sequence-specific primer polymerase chain reaction. Results. ApoE4 allele frequencies were highest among AD with comorbid DM (0.35) followed by AD without DM (0.25), nAD with DM (0.13), nAD without comorbid DM (0.12), and NC (0.08). Frequency of ApoE4 in persons with f/hAD was 0.13. The association of AD with co-morbid DM in ApoE4 carriers was more in comparison to NC with DM (OR = 5.68, P = 0.04). Conclusion. There is a significant association between AD with co-morbid DM and ApoE4 genotype.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Lakshmi Narayanan
LN
Kota
Bhagyalakshmi Mallapura
BM
Shankarappa
Prafulla
P
Shivakumar
Shilpa
S
Sadanand
Bhavani Shankara
BS
Bagepally
Srinivas Brahmadevarahalli
SB
Krishnappa
Meera
M
Purushottam
Palanimuthu Thangaraju
PT
Sivakumar
Sanjeev
S
Jain
Mathew
M
Varghese
Srikala
S
Bharath