Aromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activity.
Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an in vitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.
Dipartimento di Chimica, Sapienza Università di Roma, Piazzale Aldo Moro, 5-00185-Roma, Italy. alessandro.venditti@uniroma1.it
Alessandro
A
Venditti
Anna Maria
AM
Serrilli
Luisa
L
Rizza
Giuseppina
G
Frasca
Venera
V
Cardile
Francesco Paolo
FP
Bonina
Armandodoriano
A
Bianco
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D018932:Chemokine CCL2 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D031658:Olea / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005419:Flavonoids; D016209:Interleukin-8; C080220:aromadedrin