Novel sulphur-rich BODIPY systems that enable stepwise fluorescent O-atom turn-on and H2O2 neuronal system probing.
Bis-arylsulfide BODIPY systems were prepared and studied for multiple O-atom sensing (at 522 nm); 2- and 3-atom loading was optimal (50-fold, "turn on"). Neuronal studies showed greater H(2)O(2) sensitivity than 2',7'-dichlorofluorescein diacetate. The novel 1,3,6-trimethyl BODIPY formed as a biproduct under Lindsey conditions.
Molecular Logic Gate Laboratory, Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Atul P
AP
Singh
Kang Mun
KM
Lee
Dhiraj P
DP
Murale
Taehong
T
Jun
Hyunjeong
H
Liew
Yoo-Hun
YH
Suh
David G
DG
Churchill
D001896:Boron Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D002723:Chlorobenzoates / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D008968:Molecular Conformation; D009474:Neurons / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D002723:Chlorobenzoates; D005456:Fluorescent Dyes; D013455:Sulfur; D003300:Copper; D006861:Hydrogen Peroxide; C000433:3-chloroperbenzoic acid; D010100:Oxygen