Trophectoderm morphology significantly affects the rates of ongoing pregnancy and miscarriage in frozen-thawed single-blastocyst transfer cycle in vitro fertilization.
OBJECTIVE
To determine which parameter of blastocyst morphology is the most important predictor of ongoing pregnancy or miscarriage.


METHODS
Retrospective analysis.


METHODS
One in vitro fertilization (IVF) center.


METHODS
Women who underwent a total of 1,087 frozen-thawed single-blastocyst transfer cycles.


METHODS
First IVF treatment with blastocysts after frozen-thawed cycle.


METHODS
Ongoing pregnancy and miscarriage rates as related to blastocyst morphology (blastocyst expansion, inner cell mass, and trophectoderm), and interaction tests in unadjusted logistic regression models to assess clinical factors affecting outcomes.


RESULTS
After adjustment for trophectoderm, inner cell mass, and age as confounders, trophectoderm was determined to be statistically significantly related to the rate of ongoing pregnancy. Trophectoderm was also statistically significantly related to the miscarriage rate. By contrast, neither inner cell mass nor blastocyst expansion was statistically significantly related.


CONCLUSIONS
In frozen-thawed embryo transfer cycles, trophectoderm morphology is statistically significantly related to the rates of ongoing pregnancy and miscarriage after adjusting for confounders. Trophectoderm morphology may be the most important parameter when selecting a single blastocyst for transfer.
Asada Ladies' Clinic, Aichi, Japan. hihonma@sapmed.ac.jp
Hiroyuki
H
Honnma
Tsuyoshi
T
Baba
Masahiro
M
Sasaki
Yoshiki
Y
Hashiba
Hiroshi
H
Ohno
Takanori
T
Fukunaga
Toshiaki
T
Endo
Tsuyoshi
T
Saito
Yoshimasa
Y
Asada
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D001755:Blastocyst / Q000502:physiology; D015925:Cryopreservation / Q000379:methods / Q000639:trends*; D004475:Ectoderm / Q000166:cytology* / Q000502:physiology; D004624:Embryo Transfer / Q000379:methods / Q000639:trends*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000639:trends*; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies