Cardiac conduction block at multiple levels caused by arsenic trioxide therapy.
We present a rare case of a woman aged 62 years with refractory acute promyelocytic leukemia treated with arsenic trioxide leading to progressive, multilevel cardiac conduction block. After chelation treatment with dimercaprol, there was normalization of conduction.
Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.
Kala
K
Kathirgamanathan
Paul
P
Angaran
Alejandro
A
Lazo-Langner
Lorne J
LJ
Gula
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects* / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use; D004112:Dimercaprol / Q000627:therapeutic use; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006131:Growth Inhibitors; D006327:Heart Block / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D008875:Middle Aged; D010087:Oxides / Q000009:adverse effects* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001152:Arsenicals; D002614:Chelating Agents; D006131:Growth Inhibitors; D010087:Oxides; D004112:Dimercaprol; D000077237:Arsenic Trioxide