Cardiac actions of protein kinase C isoforms.
Protein kinase C (PKC) isoforms have emerged as important regulators of cardiac contraction, hypertrophy, and signaling pathways that influence ischemic/reperfusion injury. This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics.
Department of Pharmacology, Columbia University, New York, New York, USA. sfs1@columbia.edu
Susan F
SF
Steinberg
D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*
D007527:Isoenzymes; D011493:Protein Kinase C