Metastasis of sigmoid colon cancer in cryptorchid testis: report of a case.
Isolated testicular metastasis from colorectal cancer is considered an unusual event. In this case report we describe for the first time a metastasis from an adenocarcinoma of the sigmoid colon to a cryptorchid testis. The patient developed a painless testicular nodule three years after the diagnosis of primary sigmoid colon cancer. Recent reports have suggested that the incidence of genitourinary abnormalities in human males has increased over the past 50 years; in particular, cryptorchid testes increase the clinical risk factors for primary or metastatic testicular cancer. In conclusion, there should be awareness of the risk of metastasis of colorectal cancer to the testis in the workup of patients with testicular symptoms. Furthermore, patients with colorectal cancer and cryptorchidism should be managed with a single surgical intervention: when the primary colorectal tumor is removed, the cryptorchid testicle should also be removed to reduce the risk of late metastases.
Division of General Surgery B, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Mario
M
Rampa
Luigi
L
Battaglia
Andrea
A
Caprotti
Giacomo
G
Gazzano
Pierpaolo
P
Prestianni
Cecilia
C
Muscarà
Alberto
A
Vannelli
D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D000068258:Bevacizumab; D014408:Biomarkers, Tumor / Q000032:analysis; D000071616:CDX2 Transcription Factor; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003456:Cryptorchidism / Q000150:complications*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D018398:Homeodomain Proteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D012811:Sigmoid Neoplasms / Q000473:pathology*; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000556:secondary*; D014057:Tomography, X-Ray Computed
D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin