Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain.
L-deprenyl is considered to protect against age-related cognitive deficits by improving long-term learning/memory in the aged brain. The CA1 and CA3 hippocampal areas are the sites at which initial learning and memory processes occur. Chronic deprenyl treatment significantly augmented the basal electrical firing rate (multiple-unit action potentials), and Na+, K(+)-ATPase and protein kinase C activities of both CA1 and CA3 indicating that the drug increased the excitability of CA1 and CA3. The increase, however, was much greater in CA1 than in CA3 suggesting that deprenyl can improve longer-term learning in aged animals by its excitability-enhancing action in CA1. The drug also countered the ageing-related loss of hippocampal protein kinase C activity.
School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
Rameshwar
R
Singh
Monika
M
Mishra
Sangeeta
S
Singh
Deepak
D
Sharma
D000200:Action Potentials / Q000187:drug effects; D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D004569:Electroencephalography; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D007858:Learning / Q000187:drug effects; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012044:Regression Analysis; D012642:Selegiline / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D012642:Selegiline; D011493:Protein Kinase C; D000254:Sodium-Potassium-Exchanging ATPase