No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility.
Brain-derived neurotrophic factor (BDNF) plays important roles in neuronal development and reproductive action. Abnormal expression of BDNF gene has been detected in human sperm and seminal serum. In the present study, we investigated the possible association of G196A and C270T polymorphism of BDNF gene with male infertility. The genotypes of the G196A and C270T polymorphisms were in Hardy-Weinberg equilibrium both in fertile and infertile group. The genotype distribution frequencies were similar between infertile and fertile group. The results showed that the G196A and C270T polymorphism of the BDNF gene is unrelated to the male infertility, at least in a Chinese population.
College of Animal Science and Veterinary Medicine, Jilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, Jilin Province 130062, China.
Ch
Ch
Li
L
L
Zheng
Y
Y
Sun
Ch
Ch
Wang
W
W
Li
Ch
Ch
Lu
X
X
Zhou
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
D019208:Brain-Derived Neurotrophic Factor