The spectrum of genital human papillomavirus infection among men attending a Swedish sexually-transmitted infections clinic: human papillomavirus typing and clinical presentation of histopathologically benign lesions.
There have been a number of Swedish studies on human papillomavirus (HPV) typing in men, most of which have used less sensitive HPV-typing techniques. The present study included male patients with genital HPV-induced lesions planned for surgery. Samples were prepared for histopathology and PCR. HPV was detected in 233/253 (92%) and HPV 6 or 11 in 89% of the HPV-positive lesions. There were statistically significant differences regarding morphology (p=0.002), location (p=0.000001) and colour (p=0.005) of the lesions for low- vs. mixed or high-risk HPV types. For example, acuminate lesions were mostly found among men with low-risk HPV types, whereas macular lesions were over-represented among them with mixed or high-risk types. The HPV type distribution is similar to that in earlier studies, but we also found correlations with some clinical parameters.
Department of Dermatology and Venereology, Karolinska Hospital and Institute of Medicine, Karolinska Institutet, Stockholm, Sweden. arne.vikstrom@karolinska.se
Arne
A
Wikström
Ismini
I
Vassilaki
Mari-Anne
MA
Hedblad
Stina
S
Syrjänen
D000554:Ambulatory Care Facilities; D001706:Biopsy; D003218:Condylomata Acuminata / Q000473:pathology / Q000821:virology*; D015344:DNA Probes, HPV; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000635:transmission / Q000821:virology*; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013548:Sweden; D047568:Unsafe Sex
D015344:DNA Probes, HPV