Management of epilepsy associated with tuberous sclerosis complex (TSC): clinical recommendations.
Tuberous sclerosis complex (TSC) is a leading genetic cause of epilepsy. TSC-associated epilepsy generally begins during the first year of life, and is associated with neurodevelopmental and cognitive problems. Management is challenging and seizures tend to persist in a large proportion of patients despite pharmacological and surgical treatment. This report summarizes the clinical recommendations for the management of TSC-associated epilepsy made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined.
Department of Neurosciences, Pediatric Neurology Unit, Tor Vergata University, via Montpellier 1, 00133 Rome, Italy. curatolo@uniroma2.it
Paolo
P
Curatolo
Sergiusz
S
Jóźwiak
Rima
R
Nabbout
D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D032921:Consensus; D055423:Diet, Ketogenic; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D017408:Guidelines as Topic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019635:Neurosurgical Procedures; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D014402:Tuberous Sclerosis / Q000150:complications*; D055536:Vagus Nerve Stimulation
D000927:Anticonvulsants; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases