Multifunctional Fe3O4/TaO(x) core/shell nanoparticles for simultaneous magnetic resonance imaging and X-ray computed tomography.
Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe(3)O(4) nanoparticles (NPs) was used to synthesize multifunctional Fe(3)O(4)/TaO(x) core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.
World Class University Program of Chemical Convergence for Energy & Environment, Institute of Chemical Processes, and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
Nohyun
N
Lee
Hye Rim
HR
Cho
Myoung Hwan
MH
Oh
Soo Hong
SH
Lee
Kangmin
K
Kim
Byung Hyo
BH
Kim
Kwangsoo
K
Shin
Tae-Young
TY
Ahn
Jin Woo
JW
Choi
Young-Woon
YW
Kim
Seung Hong
SH
Choi
Taeghwan
T
Hyeon
D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D003952:Diagnostic Imaging; D004655:Emulsions; D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis*; D051381:Rats; D013635:Tantalum / Q000737:chemistry*; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D004655:Emulsions; D005290:Ferric Compounds; D013635:Tantalum