Modulation of telomere binding proteins: a future area of research for skin protection and anti-aging target.
Telomere shortening is considered as one of the main characteristics of cellular aging by limiting cellular division. Besides the fundamental advances through the discoveries of telomere and telomerase, which were recognized by a Nobel Prize, telomere protection remains an essential area of research. Recently, it was evidenced that studying the cross-talks between the proteins associated with telomere should provide a better understanding of the mechanistic basis for telomere-associated aging phenotypes. In this review, we discuss the current knowledge on telomere shortening, telomerase activity, and the essential role of telomere binding proteins in telomere stabilization and telomere-end protection. This review highlights the capacity of telomere binding proteins to limit cellular senescence and to maintain skin tissue homeostasis, which is of key importance to reduce accelerated tissue aging. Future studies addressing telomere protection and limitation of DNA damage response in human skin should include investigations on telomere binding proteins. As little is known about the expression of telomere binding proteins in human skin and modulation of their expression with aging, it remains an interesting field of skin research and a key area for future skin protection and anti-aging developments.
ASI-Vincience, Global Skin Research Center, Sophia-Antipolis Cedex, France. iimbert@ashland.com
Isabelle
I
Imbert
Jean-Marie
JM
Botto
Claude D
CD
Farra
Nouha
N
Domloge
D006801:Humans; D012867:Skin / Q000201:enzymology* / Q000378:metabolism; D015595:Skin Aging; D012879:Skin Physiological Phenomena; D019098:Telomerase / Q000378:metabolism*; D059505:Telomere Homeostasis; D034501:Telomere-Binding Proteins / Q000378:metabolism*
D034501:Telomere-Binding Proteins; D019098:Telomerase