Vault particles: a new generation of delivery nanodevices.
Vault particles possess many attributes that can be exploited in nanobiotechnology, particularly in the creation of drug delivery nanodevices. These include self-assembly, 100 nm size range, a dynamic structure that may be controlled for manipulation of drug release kinetics and natural presence in humans ensuring biocompatibility. The flexibility and the adaptability of this system have been greatly enhanced by the emerging atomic-level information and improved comprehension of vault structure and dynamics. It seems likely that this information will allow their specific tailoring to the individual requirements of each drug and target tissue. These properties provide vaults with an enormous potential as a versatile delivery platform.
Institut de Biología Molecular de Barcelona, Parc Científic de Barcelona, Baldiri i Reixac 10, 08028 Barcelona, Spain.
Arnau
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Casañas
Pablo
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Guerra
Ignasi
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Verdaguer
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D009928:Organ Specificity; D020394:Vault Ribonucleoprotein Particles / Q000737:chemistry* / Q000378:metabolism* / Q000493:pharmacokinetics
D001672:Biocompatible Materials; D020394:Vault Ribonucleoprotein Particles