Neuroendocrine tumor of the uterine cervix: a clinicopathologic study of 14 cases.
OBJECTIVE
The study explored the clinicopathologic characteristics of the neuroendocrine tumor of uterine cervix (NTUC).


METHODS
The general information and the clinical-pathological characteristics of 14 NTUC cases were reviewed.


RESULTS
The median age of the cases was 41 years. Six cases (42.9 %) were FIGO stage Ib1, four cases (28.6 %) were Ib2, one case was IIa2 (7.1 %), one case (7.1 %) was IIb, one case (7.1 %) was IIIb and one case (7.1 %) was IVb. Radical hysterectomy and bilateral salpingo-oophorotomy plus pelvic lymphadenectomy were performed on seven cases: three cases had radical hysterectomy plus pelvic lymphadenectomy; one case had transabdominal hysterectomy; and one case had a residual cervical resection. Four cases had positive pelvic lymph nodes. Two cases (14.3 %) had the tumor infiltrated to the parametrium and five cases (35.7 %) to lymphovascular space. One case had positive margin of vagina. Nine cases (64.3 %) were administered post-surgery radiotherapy and all cases were given adjuvant chemotherapy. The median follow-up time was 10 months. The median disease-free survival was 6 months, and the median total survival time was 18 months. The median estimated survival time was 32.0 months (95 % CI 16.9-47.1 months).


CONCLUSIONS
NTUC is a very rare malignant tumor of female genital tract. Multi-center cooperation to gather more cases is the best method to explore the biological behavior and for the proper treatment of NTUC.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, People's Republic of China. pengp1999@yahoo.com.cn
Peng
P
Peng
Wu
W
Ming
Yang
Y
Jiaxin
Shen
S
Keng
D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000556:secondary / Q000628:therapy*; D018287:Carcinoma, Large Cell / Q000556:secondary / Q000628:therapy*; D018288:Carcinoma, Small Cell / Q000556:secondary / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010052:Ovariectomy; D018714:Radiotherapy, Adjuvant; D058994:Salpingectomy; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*