TGF-β drives DNA demethylation.
In this issue of Molecular Cell, Thillainadesan et al. (2012) provide evidence that Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth factor β (TGF-β) transcriptional response.
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA. dw2p@virginia.edu
David
D
Wotton