(99m)Tc-labeled ubiquicidin scintigraphy: a promising method in hip prosthesis infection diagnosis.
OBJECTIVE
Hip prosthesis implantation has witnessed a significant increase in recent years. Despite the advantages of this surgical procedure, it has some complications, the most serious of which is prosthetic infection. This study was conducted to investigate the feasibility of 99mTc-UBI scintigraphy in detection of infectious foci in painful hip prosthesis. UBI (Ubiquicidin 29-41) is an antimicrobial peptide fragment with the ability to target the bacterial colony directly.


METHODS
34 patients, aged 20-79 years, with painful hip prosthesis were included. 99mTc-UBI scan and three phase bone scan were performed and two nuclear medicine specialists interpreted the UBI scans with and without bone scan results at hand. Both qualitative and semi-quantitative methods were used to interpret the 30 minute post injection images. The patients were actively followed up. According to the surgical findings, microbiological culture and active follow up, final diagnosis was made.


RESULTS
24 negative and 10 positive UBI scans were recorded. The sensitivity, specificity, negative and positive predictive values and accuracy of the study were all 100%. Bone scan did not have any influence on UBI interpretation. We were able to achieve excellent differentiation between infected and non-infected prostheses with a cut off value of 1.8 for target to non target (T/NT) ratio. No adverse effects were noticed following UBI scan.


CONCLUSIONS
Based on the findings, the authors believe that 99mTc-UBI scintigraphy, with its high sensitivity and specificity, provides the physician with an excellent tool for differentiating infection from aseptic loosening of hip prostheses. Using this radiopharmaceutical, it is possible to obtain highly accurate results only 30 minutes after the beginning of the study.
Nuclear Medicine Research Center, Mashhad University of Medical Science, Imam Reza Hospital, Mashhad, Iran.
K
K
Aryana
A
A
Hootkani
R
R
Sadeghi
Y
Y
Davoudi
M
M
Naderinasab
M
M
Erfani
N
N
Ayati
D000328:Adult; D000368:Aged; D000818:Animals; D005240:Feasibility Studies; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000209:etiology*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012269:Ribosomal Proteins; D012680:Sensitivity and Specificity; D013667:Technetium; D055815:Young Adult
D019275:Radiopharmaceuticals; D012269:Ribosomal Proteins; C040469:ribosomal protein S30; D013667:Technetium