The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients.
BACKGROUND
The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.


RESULTS
The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.


CONCLUSIONS
ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.
Department of Rehabilitation Medicine, Tokai University School of Medicine, and Department of Rehabilitation Medicine, National Hokone Hospital, Kanagawa, 259-1193, Japan. rhkasa@is.icc.u-tokai.ac.jp
Takashi
T
Kasahara
Kentaro
K
Terasaki
Yuki
Y
Ogawa
Junichi
J
Ushiba
Harumichi
H
Aramaki
Yoshihisa
Y
Masakado
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications*; D003344:Cortical Synchronization / Q000502:physiology*; D004185:Disability Evaluation; D004569:Electroencephalography; D005260:Female; D006225:Hand; D006801:Humans; D019018:Imagery, Psychotherapy / Q000379:methods; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology*; D011597:Psychomotor Performance / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors