A possible association between ZNRD1 and aspirin-induced airway bronchoconstriction in a Korean population.
BACKGROUND
The etiology of aspirin-exacerbated respiratory disease (AERD) has been attributed to the combination of environmental and genetic risk factors. Although widely investigated in various diseases associated with immune dysfunction, the human zinc ribbon domain containing 1 (ZNRD1) gene is thought to play a role in the pathogenesis of AERD by altering the mechanisms involved in disease development.


METHODS
We selected 6 single-nucleotide polymorphisms (SNPs) for genotyping from the International HapMap database in order to analyze the association between polymorphisms in ZNRD1 and AERD in a Korean asthma cohort. Genotyping was carried out using the TaqMan assay, and differences in genotype frequency distributions were analyzed using logistic regression models.


RESULTS
Nominal associations were found between ZNRD1 rs1150740 and risk ofAERD via codominant and dominant genetic inheritance (P=.03; odds ratio, 1.14 [1.14-10.16]). The same polymorphism was found to be significantly associated with a decrease in forced expiratory volume in the first second of expiration, an important diagnostic marker of AERD, even after multiple testing corrections (P=.006, P(corr)=.03 in codominant and dominant models).


CONCLUSIONS
These preliminary findings suggest a possible relationship between ZNRD1 and aspirin-induced respiratory dysfunctions in a Korean population and provide essential information on the etiology of AERD.
Department of Life Science, Sogang University, Seoul, Republic of Korea.
C F A
CF
Pasaje
J S
JS
Bae
B-L
BL
Park
H S
HS
Cheong
A-S
AS
Jang
S-T
ST
Uh
M-K
MK
Kim
J-H
JH
Kim
T-J
TJ
Park
J-S
JS
Lee
Y
Y
Kim
C-S
CS
Park
H D
HD
Shin
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000235:genetics; D016084:Bronchoconstriction / Q000187:drug effects / Q000235:genetics; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060148:HapMap Project; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
D004268:DNA-Binding Proteins; C406241:POLR1H protein, human; D001241:Aspirin