Support Vector Machine on fluorescence landscapes for breast cancer diagnostics.
Excitation-emission matrices (EEM) and total synchronous fluorescence spectra (SFS) of normal and malignant breast tissue specimens are measured in UV-VIS spectral region to serve as data inputs in development of Support Vector Machine (SVM) based breast cancer diagnostics tool. Various input data combinations are tested for classification accuracy using SVM prediction against histopathology findings to discover the best combination regarding diagnostics sensitivity and specificity. It is shown that with EEM data SVM provided 67% sensitivity and 62% specificity diagnostics. With SFS data SVM provided 100% sensitivity and specificity for a several input data combinations. Among these combinations those that require minimal data inputs are identified.
Vinča Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia.
Tatjana
T
Dramićanin
Lea
L
Lenhardt
Ivana
I
Zeković
Miroslav D
MD
Dramićanin
D001940:Breast / Q000166:cytology / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D060388:Support Vector Machine