Progression to dementia in a population with amnestic mild cognitive impairment: clinical variables associated with conversion.
The aim of this study was to investigate clinical predictors of, and rates of conversion to, dementia syndrome in a case series of patients with amnestic mild cognitive impairment (aMCI). Two hundred and eight aMCI subjects were followed over a six-year period. A lower Mini Mental State Examination score was a significant predictor of dementia, and mild cognitive impairment patients with behavioral and psychiatric symptoms showed a faster conversion rate.
Department of Clinical Medicine, University of Insubria, Varese, Italy.
Marco
M
Mauri
Elena
E
Sinforiani
Chiara
C
Zucchella
Maria Giovanna
MG
Cuzzoni
Giorgio
G
Bono
D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D003704:Dementia / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies