Pentoxifylline use in dermatology.
Pentoxifylline is methylxanthine derivative which is used in microcirculatory disorders as a vasoactive drug. Novel immunomodulatory properties of pentoxifylline have been reported including the down regulation of tumour necrosis factor-α synthesis and other inflammatory cytokines. Studies have shown that pentoxifylline might be efficacious in a wide spectrum of skin diseases. This article focuses on the use of pentoxifylline which is a safe and cheap drug in various dermatological disorders.
Ankara Numune Education and Research Hospital Dermatology Clinic, 701. sok 18/8 Yildiz Çankaya, Ankara, Turkey. seraycakmak@yahoo.com
Seray Külcü
SK
Çakmak
Atil
A
Çakmak
Müzeyyen
M
Gönül
Arzu
A
Kiliç
Ülker
Ü
Gül
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D016527:Drug Costs; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D010431:Pentoxifylline / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000187:drug effects
D016207:Cytokines; D010726:Phosphodiesterase Inhibitors; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline