A catalytic asymmetric Ugi-type reaction with acyclic azomethine imines.
An unconventional Ugi: A catalytic asymmetric Ugi-type reaction can be realized by use of N'-alkylbenzohydrazide, instead of a conventional amine, in the presence of an axially chiral dicarboxylic acid. The reaction proceeds through a key acyclic azomethine imine intermediate, which has recently emerged as a promising electrophile in asymmetric catalysis.
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Takuya
T
Hashimoto
Hidenori
H
Kimura
Yu
Y
Kawamata
Keiji
K
Maruoka