QT variability in amyloidosis of familial Mediterranean fever.
BACKGROUND
The association between familial Mediterranean fever (FMF) and increased risk for ventricular arrhythmias is controversial, and data on this subject are meager.


OBJECTIVE
To evaluate QT variability index (QTVI) and other repolarization markers associated with arrhythmogenity in patients with amyloidosis of FMF.


METHODS
The study group comprised 12 FMF patients with amyloidosis, and 14 age and gender-matched healthy subjects served as the control group. QT measurements were conducted according to accepted procedure, using computerized software for recording and analysis.


RESULTS
No differences were found in clinical and demographic parameters in the study and control groups, except for hypertension which was more common in the FMF amyloidosis group. QTc and power spectral analysis of QT variability parameters were similar in both groups. Nevertheless, QTVI values in FMF amyloidosis patients were significantly higher than in healthy individuals (-1.02 +/- 0.38, vs. -1.36 +/- 0.32 respectively, P = 0.02).


CONCLUSIONS
Compared with healthy controls, amyloidosis of FMF is associated with increased QTVI. It remains unknown whether this finding is solely amyloidosis related and whether it has any prognostic significance.
Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa, Israel.
Udi
U
Nussinovitch
Ilan
I
Ben-Zvi
Avi
A
Livneh
D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000209:etiology*; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D010505:Familial Mediterranean Fever / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged