Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.
Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany.
Alexander G
AG
O'Brien
Zoltán
Z
Horváth
François
F
Lévesque
Ju Weon
JW
Lee
Andreas
A
Seidel-Morgenstern
Peter H
PH
Seeberger