Healing of fresh extraction sockets filled with bioactive glass particles: histological findings in humans.
OBJECTIVE
The aim of the present study was to histologically evaluate fresh human sockets filled with bioactive glass after 6 months of healing.


METHODS
In 13 patients, 32 single extraction sites in the anterior area underwent socket ridge preservation procedure (RPP) with a bioactive glass (BioRestore™, Inion Oy, Tampere, Finland). At implant installation, 22 bone cores were trephined out and processed for histomorphometric and immunohistochemical analysis.


RESULTS
Newly formed immature bone around residual particles of bioactive glass was found in all 22 biopsies. The histomorphometry of the amount of bone, provisional matrix, and residual graft returned a mean ± SD value of 54 ± 31%, 37.9 ± 25.6%, and 8.1 ± 7.8, respectively, 6 months after RPP.


CONCLUSIONS
The use of this grafting material in fresh extraction sockets appears to delay the healing processes of the alveolar bone; therefore, its indication as a material for RPP when implant placement is considered within 6 months after extraction should be revised.
Resident, Ashman Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY, USA Head, Department of Pathology, Ospedale Orlandi, Bussolengo, Verona, Italy Director, Research Unit of Paleoradiology and Allied Sciences, Ospedali Riuniti di Trieste, Trieste, Italy R&D manager, Inion Oy, Tampere, Finland Full professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy Assistant professor, Division of Dental Sciences and Biomaterials, Department of Biomedicine, University of Trieste, Trieste, Italy.
Emanuele
E
Clozza
Maurizio
M
Pea
Fabio
F
Cavalli
Loredana
L
Moimas
Roberto
R
Di Lenarda
Matteo
M
Biasotto
D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D005260:Female; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D014081:Tooth Extraction; D020390:Tooth Socket; D014945:Wound Healing
D001672:Biocompatible Materials