Delay discounting in Lewis and Fischer 344 rats: steady-state and rapid-determination adjusting-amount procedures.
Lewis rats have been shown to make more impulsive choices than Fischer 344 rats in discrete-trial choice procedures that arrange fixed (i.e., nontitrating) reinforcement parameters. However, nontitrating procedures yield only gross estimates of preference, as choice measures in animal subjects are rarely graded at the level of the individual subject. The present study was designed to examine potential strain differences in delay discounting using an adjusting-amount procedure, in which distributed (rather than exclusive) choice is observed due to dynamic titration of reinforcer magnitude across trials. Using a steady-state version of the adjusting-amount procedure in which delay was manipulated between experimental conditions, steeper delay discounting was observed in Lewis rats compared to Fischer 344 rats; further, delay discounting in both strains was well described by the traditional hyperbolic discounting model. However, upon partial completion of the present study, a study published elsewhere (Wilhelm & Mitchell, 2009) demonstrated no difference in delay discounting between these strains with the use of a more rapid version of the adjusting-amount procedure (i.e., in which delay is manipulated daily). Thus, following completion of the steady-state assessment in the present study, all surviving Lewis and Fischer 344 rats completed an approximation of this rapid-determination procedure in which no strain difference in delay discounting was observed.
University of Kansas, USA. jeff.stein@aggiemail.usu.edu
Jeffrey S
JS
Stein
Jonathan W
JW
Pinkston
Adam T
AT
Brewer
Monica T
MT
Francisco
Gregory J
GJ
Madden
D000818:Animals; D002755:Choice Behavior; D003216:Conditioning, Operant; D007175:Impulsive Behavior / Q000523:psychology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000523:psychology; D011917:Rats, Inbred Lew / Q000523:psychology; D012054:Reinforcement, Psychology; D013997:Time Factors