Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial.
Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin-8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne.
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Hyuck Hoon
HH
Kwon
Ji Young
JY
Yoon
Jong Soo
JS
Hong
Jae Yoon
JY
Jung
Mi Sun
MS
Park
Dae Hun
DH
Suh
D000152:Acne Vulgaris / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D050528:Diet, Carbohydrate-Restricted; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats; D004044:Dietary Proteins; D002149:Energy Intake; D005260:Female; D038321:Glycemic Index; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D056910:Republic of Korea; D012627:Sebaceous Glands / Q000473:pathology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D055815:Young Adult
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D016209:Interleukin-8; D051780:Sterol Regulatory Element Binding Protein 1; D016212:Transforming Growth Factor beta