Clinical outcomes after the use of complete autologous oral mucosa equivalents: preliminary cases.
OBJECTIVE
Previously, we reported how to obtain complete autologous oral mucosa equivalents (CAOMEs) composed of an autologous plasma scaffold and fibroblasts together with immature keratinocytes able to build an oral epithelium with a structure similar to that of the oral mucosa. In this study, we present the clinical outcomes after applying our CAOMEs as grafts.


METHODS
Four patients who needed a CAOME to restore a defect of oral mucosa were selected. Two of the patients suffered from ankyloglossia, and the other 2 required a restoration of the keratinized gum of the alveolar rim. To assess the outcomes, the scale designed by Ewers et al. was used.


RESULTS
Clinical and functional improvements were achieved in the patients with ankyloglossia. In cases of gum restoration, the mucosa was regenerated and a prosthetic restoration with implants was achieved.


CONCLUSIONS
The results obtained points to the potential use of CAOME in intraoral lining.
Oral and Maxillofacial Surgeon, Central University Hospital of Asturias, Oviedo, Spain. napegomaxilo@gmail.com
Ignacio
I
Peña
Luis Manuel
LM
Junquera
Santiago
S
Llorente
Lucas
L
de Villalaín
Juan Carlos
JC
de Vicente
Sara
S
Llames
D018929:Cell Culture Techniques; D002478:Cells, Cultured; D015718:Fibrin Tissue Adhesive; D005347:Fibroblasts / Q000637:transplantation; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D008567:Membranes, Artificial; D009061:Mouth Mucosa / Q000166:cytology* / Q000502:physiology / Q000601:surgery; D009062:Mouth Neoplasms / Q000601:surgery; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous
D015718:Fibrin Tissue Adhesive; D008567:Membranes, Artificial