Gold-catalyzed synthesis of substituted 2-aminofurans via formal [4+1]-cycloadditions on 3-en-1-ynamides.
Gold-catalyzed formal [4+1]-cycloadditions between 3-en-1-ynamides 1 and 8-methylquinoline oxide are reported. The success of this reaction relies on a hypothetic oxa-Nazarov cyclization on gold-stabilized allylic cations. Preliminary results on a new 1,2-difunctionalization of 3-en-1-ynamide are also reported.
Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
Ramesh B
RB
Dateer
Kamalkishore
K
Pati
Rai-Shung
RS
Liu