Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial.
Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena(®) ELFA(®)955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements.



A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement.



Chronic WGOE supplementation did not affect any measures of cognition.



It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic treatment in older adults with normal cognition. It remains to be seen whether sustained effects of WGOE supplementation may be more evident in those with mild cognitive impairment.
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia 5001, Australia. rachel.wong@mymail.unisa.edu.au
Rachel H X
RH
Wong
Peter R C
PR
Howe
Janet
J
Bryan
Alison M
AM
Coates
Jonathan D
JD
Buckley
Narelle M
NM
Berry
D000368:Aged; D001288:Attention / Q000187:drug effects*; D018554:Avena / Q000737:chemistry*; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts