Tyrosinase inhibition constituents from the roots of Morus australis.
The phytochemical profiles of Morus australis roots, stems and twigs were firstly compared by HPLC analysis. It was found that Morus australis stem extract mainly contained one known tyrosinase inhibitor, oxyresveratrol, while its root and twig extract might contain some unknown potential tyrosinase inhibitors. The root extract of Morus australis was further investigated in this study. One new compound, austraone A, together with 21 known compounds, was isolated and their structures were identified by interpretation of MS and NMR data. In the tyrosinase inhibitory testing, some of them, such as oxyresveratrol, moracenin D, sanggenon T, and kuwanon O, exhibited stronger tyrosinase inhibitory activities than that of kojic acid. These results suggested the Morus australis root extract as a good source of natural tyrosinase inhibitors with a great potential to be used in foods as anti-browning agents and in cosmetics as skin-whitening agents.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, PR China.
Zong-Ping
ZP
Zheng
Hui-Yuan
HY
Tan
Mingfu
M
Wang
D000363:Agaricales / Q000201:enzymology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D031625:Morus / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D011753:Pyrones / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D001572:Benzofurans; D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D010636:Phenols; D010936:Plant Extracts; D011753:Pyrones; D013267:Stilbenes; C576422:austraone A; C574050:moracenin D; C011890:kojic acid; D014442:Monophenol Monooxygenase; D000077185:Resveratrol