Utilization of low-molecular-weight heparin prophylaxis in pediatric and adolescent trauma patients.
The objective of this study was to use trauma registry data to describe the number and characteristics of patients 21 years or younger receiving thromboprophylaxis with low-molecular-weight heparin at 2 pediatric and 2 adult level 1 trauma centers. Among 706 patients, the average age was 18.5 years, and 94.6% were hospitalized at adult centers. The most common injuries were lower extremity fractures (35.6%) and head injuries (20.4%). Major bleeding was reported in 3 patients (0.4%), and thrombotic events were reported in 15 patients (2.1%). Despite a lack of scientific evidence, low-molecular-weight heparin prophylaxis is being used in young trauma patients (primarily those 14 years or older). Prospective multicenter studies are needed to accurately describe the risks and benefits of low-molecular-weight heparin prophylaxis in young trauma patients, thereby identifying those who truly benefit from this intervention.
Nationwide Children’s Hospital, Columbus, OH 43205, USA. sarah.obrien@nationwidechildrens.org
Sarah H
SH
O'Brien
Jennifer
J
Klima
Barbara A
BA
Gaines
Sally
S
Betz
Mazen S
MS
Zenati
D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology* / Q000451:nursing / Q000517:prevention & control*; D014193:Trauma Centers / Q000706:statistics & numerical data; D014947:Wounds and Injuries / Q000453:epidemiology* / Q000451:nursing; D055815:Young Adult
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight