Cross metathesis assisted solid-phase synthesis of glycopeptoids.
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds.
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, South Korea.
Sharaf Nawaz
SN
Khan
Arim
A
Kim
Robert H
RH
Grubbs
Yong-Uk
YU
Kwon
D000475:Alkenes / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis; D002241:Carbohydrates / Q000737:chemistry*; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis*; D060327:Solid-Phase Synthesis Techniques
D000475:Alkenes; D002241:Carbohydrates; D034444:Peptoids