[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia].
It is shown that, in rats with global cerebral ischemia modeled by a complete irreversible occlusion of the common carotid artery and forced hypotension, the hemostasis is characterized by a shift toward hypercoagulation. A single preventive introduction of phenibut and, to a greater degree, a composition of phenibut with nicotinic acid, in rats with acute cerebral ischemia reduced the extent of disturbances in the hemostasis system of experimental animals.
I N
IN
Tiurenkov
E V
EV
Volotova
D V
DV
Kurkin
A A
AA
Litvinov
A S
AS
Tarasov
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D009525:Niacin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D000927:Anticonvulsants; D014665:Vasodilator Agents; D009525:Niacin; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid