Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response.
The arrest and directed migration of leukocytes during homeostasis, tumour development and inflammation is orchestrated by a multitude of chemokines, which govern leukocyte migratory activities. Immune cells are particularly adept at adjusting rapidly to changes within the environment by migration in response to chemokines. The confrontation of leukocytes with different combination of chemokines that are concomitantly produced under physiological or pathological conditions in vivo is complex. There are different ways to enhance or reduce leukocyte migration mediated by chemokines such as posttranslational modifications. Here, we described a positive regulatory mechanism in leukocyte trafficking, by the synergism between chemokines to rapidly augment the local leukocyte influx, thereby enhancing the outcome of an inflammatory response in vivo. The cellular mechanisms involved in chemokine synergy are still debated, but probably include chemokine and/or receptor heterodimerization and subsequent cooperation in signal transduction.
Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Mieke
M
Gouwy
Milena
M
Schiraldi
Sofie
S
Struyf
Jo
J
Van Damme
Mariagrazia
M
Uguccioni
D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000276:immunology*; D025461:Feedback, Physiological; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007962:Leukocytes / Q000276:immunology*; D011499:Protein Processing, Post-Translational; D011940:Receptor Aggregation; D020239:Receptor Cross-Talk; D015398:Signal Transduction
D018925:Chemokines