A DNA nanocapsule with aptamer-controlled open-closure function for targeted delivery.
A DNA capsule fitted with aptamer controlled target sensing has been "woven" using a 7308-base single-stranded DNA "thread" and 196 staple oligonucleotides. The capsule enables logic-gated molecular cargo delivery to targeted cell surfaces.
Department of Cellular and Molecular Medicine; University of Copenhagen; Copenhagen, Denmark. bentin@sund.ku.dk
Thomas
T
Bentin
D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000737:chemistry; D004277:DNA, Single-Stranded / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007128:Immunoglobulin Fragments / Q000008:administration & dosage; D019169:Jurkat Cells / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry; D009841:Oligonucleotides / Q000008:administration & dosage / Q000737:chemistry
D052157:Aptamers, Nucleotide; D004277:DNA, Single-Stranded; D006680:HLA Antigens; D007128:Immunoglobulin Fragments; D053769:Nanocapsules; D009841:Oligonucleotides