Budesonide efficacy and safety in patients with bronchiectasis not due to cystic fibrosis.
OBJECTIVE
The therapeutic benefit of inhaled corticoids in bronchiectasis not due to cystic fibrosis is still not well documented. The aim of the present study was to assess the efficacy and safety of inhaled corticoids in this disease.


METHODS
This study was conducted at a tertiary university hospital in the city of Barcelona, Catalonia, (Spain).


METHODS
A prospective, double-blind, parallel, placebo-masked study was conducted. Seventy-seven patients (40 women; mean age: 68 years) were randomly assigned to receive either 400 mcg budesonide twice daily or placebo and were regularly reviewed for six months.


RESULTS
Differences in forced vital capacity and forced expiratory volume in the first second between the beginning and end of the study were not significantly lower in the budesonide group than in the placebo group, either in absolute values [-17.4 (386.9) versus -21.4 (375.5)] or in percentages [-1.9(9.5) versus -2.8 (11.6)]. Microbiological criteria applied to evaluate changes between the beginning and end of the study showed no worsening in the budesonide group compared with the control group, whereas a non-significant improvement was obtained in 8.1 % of cases in the budesonide group compared to 3 % in the placebo group. Although significance was only achieved for sputum eosinophils (p = 0.021), a consistent tendency towards improvement was also observed in secondary end-points (symptoms, number and duration of exacerbations, quality of life, sputum cytology and interleukin-8) in the budesonide group.


CONCLUSIONS
Although further studies are required, inhaled corticoid treatment may be efficacious and safe in bronchiectasis not due to cystic fibrosis.
Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, 08035, Barcelona, Catalonia, Spain.
Rosana
R
Hernando
María Estrella
ME
Drobnic
María Jesús
MJ
Cruz
Adelaida
A
Ferrer
Pilar
P
Suñé
J Bruno
JB
Montoro
Ramon
R
Orriols
D000280:Administration, Inhalation; D000368:Aged; D001987:Bronchiectasis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D011788:Quality of Life; D013183:Sputum / Q000166:cytology / Q000382:microbiology; D014797:Vital Capacity / Q000187:drug effects
D005938:Glucocorticoids; D016209:Interleukin-8; D019819:Budesonide