Risk factors of chest pain after endoscopic resection of early esophageal cancer.
OBJECTIVE
Although endoscopic resection is sometimes associated with chest pain, the risk factors for this complication have not been investigated.


METHODS
From January 2003 to December 2007, 241 patients were treated by endoscopic resection and 139 patients who met our criteria were analyzed. The case group was 40 patients who took an analgesic after endoscopic resection because of chest pain. The controls were 79 patients who did not experience chest pain after endoscopic resection. Twenty patients experienced chest pain, but did not take any analgesics.


RESULTS
Although, 60 patients (43%) experienced chest pain, this was treatable by a common analgesic. Univariate analysis revealed that female gender had significant association and resection of posterior wall mucosa had marginal association with chest pain and analgesic use. No significant association with chest pain and analgesic use was found for age, resection method, use of acid suppressing drugs, lesion size and site. Logistic-regression analysis showed that significant risk factors for chest pain and analgesic use were female gender (odds ratio 3.45) and resection of posterior wall mucosa (odds ratio 3.13).


CONCLUSIONS
Female gender and resection of posterior wall mucosa were associated with chest pain and analgesic use after endoscopic resection.
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Takuya
T
Inoue
Ryu
R
Ishihara
Noriya
N
Uedo
Natsuko
N
Kawada
Yoshiki
Y
Tsujii
Hiromitsu
H
Kanzaki
Masao
M
Hanahusa
Noboru
N
Hanaoka
Sachiko
S
Yamamoto
Yoji
Y
Takeuchi
Koji
K
Higashino
Hiroyasu
H
Iishi
Masaharu
M
Tatsuta
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D002637:Chest Pain / Q000188:drug therapy / Q000209:etiology*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000601:surgery; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
D000700:Analgesics