Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.
A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiro-ring containing skeletons. Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.
CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
Wenjun
W
Zhang
Zhong
Z
Liu
Sumei
S
Li
Tingting
T
Yang
Qingbo
Q
Zhang
Liang
L
Ma
Xinpeng
X
Tian
Haibo
H
Zhang
Caiguo
C
Huang
Si
S
Zhang
Jianhua
J
Ju
Yuemao
Y
Shen
Changsheng
C
Zhang
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008958:Models, Molecular; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D026121:Indole Alkaloids