Impact of statin use before the onset of acute myocardial infarction on coronary plaque morphology of the culprit lesion.
Statins favorably stabilize coronary plaque. We evaluated the impact of statin use before the onset of acute myocardial infarction (AMI) on culprit lesion plaque morphology. Patients (n = 127) with AMI were divided into either a statin group (n = 31) or a nonstatin group (n = 96) based on statin use before the onset of AMI. Coronary plaque morphology of the culprit lesion was evaluated using intravascular ultrasound virtual histology (IVUS-VH) with radiofrequency data analysis before coronary intervention. The IVUS-VH identified 4 types of plaque components: fibrous, fibrofatty, dense calcium, and necrotic core. The IVUS-VH showed less percentage of necrotic area, greater percentage fibrous area, and greater percentage of fibrofatty area of the culprit lesion in the statin group. In conclusion, statin use before the onset of AMI might have effects on coronary plaque morphology of the AMI culprit lesion with less necrotic core and greater fibrous and fibrofatty component.
Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Kanagawa, Japan. hihikita2000@yahoo.co.jp
Hiroyuki
H
Hikita
Shunsuke
S
Kuroda
Yuki
Y
Oosaka
Naohiko
N
Kawaguchi
Emiko
E
Nakashima
Tomoyo
T
Sugiyama
Daiki
D
Akiyama
Tetsuo
T
Kamiishi
Shigeki
S
Kimura
Yoshihide
Y
Takahashi
Taishi
T
Kuwahara
Akira
A
Sato
Atsushi
A
Takahashi
Mitsuaki
M
Isobe
D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors; D018084:Ultrasonography, Interventional
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors