Iron-catalyzed reductive radical cyclization of organic halides in the presence of NaBH4: evidence of an active hydrido iron(I) catalyst.
Iron made'em: iron(II) complexes such as FeCl(2) and [FeCl(2)(dppe)(2) ] (dppe=1,2-bisdiphenylphosphinoethane) are efficient precatalysts for the radical cyclization of unsaturated iodides and bromides in the presence of NaBH(4). Cyclic voltammetry studies suggests that the reaction occurs through a radical mechanism via an anionic hydrido iron(I) species as the key intermediate for the activation of the substrates by electron transfer.
Institut Parisien de Chimie Moléculaire, UMR CNRS, UPMC Univ-Paris, Sorbonne Universités, France.
Audrey
A
Ekomié
Guillaume
G
Lefèvre
Louis
L
Fensterbank
Emmanuel
E
Lacôte
Max
M
Malacria
Cyril
C
Ollivier
Anny
A
Jutand