Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs.
Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.
Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu 300, Taiwan.
Shang-Hsiu
SH
Hu
Bang-Jie
BJ
Liao
Chin-Sheng
CS
Chiang
Po-Jung
PJ
Chen
I-Wei
IW
Chen
San-Yuan
SY
Chen
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D004655:Emulsions / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D051379:Mice; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D011108:Polymers / Q000737:chemistry*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D004655:Emulsions; D005290:Ferric Compounds; D053769:Nanocapsules; D011108:Polymers; C000499:ferric oxide; D004317:Doxorubicin; D017239:Paclitaxel