[Processing and analysis of ChIP-seq data].
The  next-generation sequencing coupled with chromatin immunoprecipitation (ChIP-seq) is becoming a key technology for the study of transcriptional regulation in the context of functional genomics. Due to the overwhelming amount of data generated from ChIP-seq experiments, the ChIP-seq data processing brings many new challenges in the field of bioinformatics. Considering the development of data processing skills largely behind that of the ChIP-seq experiment techniques, it is urgent to give a review on the ChIP-seq data processing for more and more oncoming researchers to build or improve algorithms. This paper provides a brief overview of the ChIP-seq data processing, highlighting the main prob-lems and methods in detail, to allow scientists to understand rapidly and deeply.
College of Mathematics, Nankai University, Tianjin 300071, China. gao_shan@mail.nankai.edu.cn
Shan
S
Gao
Ning
N
Zhang
Bo
B
Li
Shuo
S
Xu
Yan-Bo
YB
Ye
Ji-Shou
JS
Ruan
D000465:Algorithms; D000818:Animals; D047369:Chromatin Immunoprecipitation / Q000379:methods*; D019295:Computational Biology / Q000379:methods; D001330:Electronic Data Processing / Q000379:methods*; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods*