Clinical differences between acute CVST and non-thrombotic CVSS.
BACKGROUND
Cerebral venous sinus thrombosis (CVST) is a rare stroke subtype, which has many overlapping symptoms with non-thrombotic cerebral venous sinus stenosis (CVSS) in the acute phase. Despite these similarities, their therapeutic regimens and outcomes are entirely different, and treatment delay is life-threatening. This study aims to address their clinical differences to help promote proper patient care.


METHODS
34 cases of CVST and 34 cases of non-thrombotic CVSS diagnosed with digital subtraction angiography (DSA) in the acute phase (symptoms onset within 7days) were consecutively enrolled in this prospective non-randomized and controlled study. Differences between CVST and CVSS in their clinical manifestation, plasma biomarkers, and MR or DSA imaging were compared.


RESULTS
CVST and CVSS overlap in many ways, but differ in their respective medical histories and neurological deficits. However, 20.6% of CVST and 64.7% of CVSS occur without a definitive medical history, and 70.6% of CVST and 64.7% of CVSS occur without focal neurologic deficits. In the acute phase of CVST, d-dimer and fibrinogen are found to be abnormally elevated in 94.1% and 73.5% of cases, respectively. In the CVSS group, d-dimer and fibrinogen are only elevated in 17.6% and 5.9% of cases, respectively (binary logistic regressions test, all P<0.001). In the CVST group, the predominant features in MRI/MRV and DSA imaging include local brain lesions, flow void signal loss, non-visualization, and a local filling defect sign at the involved sinus. Conversely, in the CVSS group, imaging revealed symmetrically small bilateral ventricles and the spread of cerebral edema in MRI/MRV. DSA imaging in the CVSS group revealed external compression and a narrow sinus with disproportionate venous engorgement. Despite these findings, positive imaging only appears in a minority of patients in the two groups during the acute phase (Table 4).


CONCLUSIONS
DSA may be beneficial to diagnose CVST in ambiguous patients suspected to have either CVST or CVSS. Clinically useful biomarkers (d-dimer and fibrinogen) may predict CVST in the emergency room in the ambiguous patients with or without equivocal MRI/MRV imaging.
Department of Neurology, Beijing Shijitan Hospital affiliated Capital Medical University, the Ninth Clinical Medical College of Peking University, Beijing, China.
Ran
R
Meng
David
D
Dornbos
Lu
L
Meng
Yan
Y
Wu
Yu
Y
Liu
Guoqing
G
Li
Guangwen
G
Li
Sijie
S
Li
Fei
F
Sun
Xiaoying
X
Wang
Yuchuan
Y
Ding
Xunming
X
Ji
D000208:Acute Disease; D000328:Adult; D015901:Angiography, Digital Subtraction; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D002550:Cerebral Veins / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000503:physiopathology; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology; D011446:Prospective Studies; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen