Feroniellides C-E, new apotirucallane triterpenoids from the stem bark of Feroniella lucida.
Bioassay-directed isolation of Feroniella lucida stem bark yielded three new apotirucallane triterpenoids named feroniellides C-E. The structures of the new compounds were established by extensive analysis of spectroscopic data. Of triterpenoids examined, feroniellides D and E revealed anticancer activity against KB and HeLa cells with IC50 values in range of 3.4-14.2 µg mL(-1), which are significantly more potent than feroniellides A-C (IC50 25.5-60.0 µg mL(-1)). The present investigation suggests that an isovalerate moiety in feroniellides D and E is possibly associated with exerting cytotoxicity against cancer cells.
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Preecha
P
Phuwapraisirisan
Sitthidesch
S
Sombund
Santi
S
Tip-Pyang
Pongpun
P
Siripong
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C586234:feroniellide C; C586235:feroniellide D; C586236:feroniellide E