The insulin-like growth factor system in bone: basic and clinical implications.
The insulin-like growth factor (IGF) regulatory system is critical for skeletal growth and maintenance. Initially there was great hope that the recombinant IGFs might be used clinically for disorders ranging from short stature to fracture repair and osteoporosis. Although this potential was not realized, basic and translational studies have continued, providing significant insights into the role of this family of growth factors in skeletal homeostasis and the pathophysiology of several bone disorders. This article reviews the importance of the IGF regulatory system in skeletal growth and maintenance.
Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
Masanobu
M
Kawai
Clifford J
CJ
Rosen
D000818:Animals; D015519:Bone Density / Q000502:physiology; D001847:Bone Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D013002:Somatomedins / Q000378:metabolism* / Q000627:therapeutic use; D057170:Translational Research, Biomedical
D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins