Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC.
OBJECTIVE
Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition.


METHODS
Concentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1,605 prostate cancer cases and 1,697 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regression.


RESULTS
Plasma genistein concentrations were not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 1.00 (95 % confidence interval: 0.79, 1.27; p linear trend = 0.82). There was no evidence of heterogeneity in this association by age at blood collection, country of recruitment, or cancer stage or histological grade.


CONCLUSIONS
Plasma genistein concentration was not associated with prostate cancer risk in this large cohort of European men.
Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK. ruth.travis@ceu.ox.ac.uk
Ruth C
RC
Travis
Naomi E
NE
Allen
Paul N
PN
Appleby
Alison
A
Price
Rudolf
R
Kaaks
Jenny
J
Chang-Claude
Heiner
H
Boeing
Krasimira
K
Aleksandrova
Anne
A
Tjønneland
Nina Føns
NF
Johnsen
Kim
K
Overvad
J
J
Ramón Quirós
Carlos A
CA
González
Esther
E
Molina-Montes
Maria José
MJ
Sánchez
Nerea
N
Larrañaga
José María Huerta
JM
Castaño
Eva
E
Ardanaz
Kay-Tee
KT
Khaw
Nick
N
Wareham
Antonia
A
Trichopoulou
Tina
T
Karapetyan
Snorri Bjorn
SB
Rafnsson
Domenico
D
Palli
Vittorio
V
Krogh
Rosario
R
Tumino
Paolo
P
Vineis
H Bas
HB
Bueno-de-Mesquita
Pär
P
Stattin
Mattias
M
Johansson
Veronika
V
Fedirko
Teresa
T
Norat
Afshan
A
Siddiq
Elio
E
Riboli
Timothy J
TJ
Key
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005060:Europe / Q000453:epidemiology; D019833:Genistein / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D053719:Tandem Mass Spectrometry
D019833:Genistein