Germline stem cells: origin and destiny.
Germline stem cells are key to genome transmission to future generations. Over recent years, there have been numerous insights into the regulatory mechanisms that govern both germ cell specification and the maintenance of the germline in adults. Complex regulatory interactions with both the niche and the environment modulate germline stem cell function. This perspective highlights some examples of this regulation to illustrate the diversity and complexity of the mechanisms involved.
Howard Hughes Medical Institute; Skirball Institute, The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. Electronic address: lehmann@saturn.med.nyu.edu.
Ruth
R
Lehmann
D000328:Adult; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*