Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process.
A simple and highly efficient strategy for the synthesis of 3-substituted isocoumarins through a copper(I)-catalyzed reaction of 1-(2-halophenyl)-1,3-diones has been developed. The procedure is based on a cascade copper-catalyzed intramolecular Ullmann-type C-arylation and rearrangement process. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.
College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, People's Republic of China.
Zhi-Yuan
ZY
Ge
Xiang-Dong
XD
Fei
Ting
T
Tang
Yong-Ming
YM
Zhu
Jing-Kang
JK
Shen
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry
D049934:Isocoumarins; D007659:Ketones; D009942:Organometallic Compounds; D003300:Copper