NMR spectroscopic characterization of new 2,3-dihydro-1,3,4-thiadiazole derivatives.
The (1) H and (13) C NMR resonances of twenty-seven 2,2-dimethyl-5-(2-nitrophenyl-5-substituted)-2,3-dihydro-1,3,4-thiadiazoles, and twenty-seven 3-acyl-5-(2-amino-5-substituted)-2,2-dimethyl-2,3-dihydro-1,3,4-thiadiazoles were assigned completely using the concerted application of one-dimensional and two-dimensional experiments (DEPT, HMQC and HMBC). NOESY experiments, X-ray crystallography and conformational analysis confirm the preferred conformation of these compounds.
Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, Granada, Spain.
M Dora
MD
Carrión
Luisa C
LC
López-Cara
Mariem
M
Chayah
Duane
D
Choquesillo-Lazarte
Miguel A
MA
Gallo
Antonio
A
Espinosa
Antonio
A
Entrena
M Encarnación
ME
Camacho
D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D013830:Thiadiazoles / Q000737:chemistry*
D013830:Thiadiazoles