Mucormycosis after allogeneic haematopoietic stem cell transplantation: a French Multicentre Cohort Study (2003-2008).
We conducted a nationwide retrospective study to evaluate clinical characteristics and outcome of mucormycosis among allogeneic haematopoietic stem cell transplant recipients. Twenty-nine patients were diagnosed between 2003 and 2008. Mucormycosis occurred at a median of 225 days after allogeneic haematopoietic stem cell transplant, and as a breakthrough infection in 23 cases. Twenty-six patients were receiving steroids, mainly for graft-versus-host disease treatment, while ten had experienced a prior post-transplant invasive fungal infection. Twenty-six patients received an antifungal treatment; surgery was performed in 12. Overall survival was 34% at 3 months and 17% at 1 year.
Service d'Hématologie- Greffe, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France. alienor.xhaard@sls.aphp.fr
A
A
Xhaard
F
F
Lanternier
R
R
Porcher
E
E
Dannaoui
A
A
Bergeron
L
L
Clement
C
C
Lacroix
R
R
Herbrecht
F
F
Legrand
M
M
Mohty
M
M
Michallet
C
C
Cordonnier
S
S
Malak
D
D
Guyotat
L J
LJ
Couderc
G
G
Socié
N
N
Milpied
O
O
Lortholary
P
P
Ribaud
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000706:statistics & numerical data*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents