A pilot study of segmental mandibulectomy with surgical navigation using fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography.
OBJECTIVE
To evaluate the efficacy of treating lower gum cancer using fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18] F-FDG PET/CT) surgical navigation to control bony margins during segmental mandibulectomy.


METHODS
This study was conducted between September 2010 and June 2011 in a tertiary referral center in southern Taiwan.


METHODS
Segmental mandibulectomy was performed using surgical navigation via [18] F-FDG PET/CT. Bony margins after decalcification, the 1-year survival rate, and local control rate were evaluated.


RESULTS
Ten cases of advanced lower gum cancer in male patients were treated by mandibulectomy, and the bony margins required to excise all neoplastic cells were negative in all cases by using surgical navigation. The minimal distance from the tumor border to the bony incision was 2 cm (2.0-2.9 cm). The mean follow-up period was 15.2 months (range, 6-24 months) with a 1-year survival rate of 90% and local control rate of 100%.


CONCLUSIONS
The segmental mandibulectomy aided by surgical navigation with [18] F-FDG PET/CT guidance is simple and feasible to ensure adequate bony margins intraoperatively, but more patients are necessary to support these findings.
Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. cychien3965@adm.cgmh.org.tw
Chih-Yen
CY
Chien
Hui-Ching
HC
Chuang
Shu-Hua
SH
Huang
Wei-Che
WC
Lin
Husan-Ying
HY
Huang
D000368:Aged; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D063168:Mandibular Osteotomy / Q000379:methods* / Q000401:mortality; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D025321:Surgery, Computer-Assisted / Q000379:methods*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
D019788:Fluorodeoxyglucose F18