Copper(II) mediated facile and ultra fast peptide synthesis in methanol.
A novel, ultrafast, mild and scalable amide bond formation strategy in methanol using simple thioacids and amines is described. The mechanism suggests that the coupling reactions are initially mediated by CuSO(4)·5H(2)O and subsequently catalyzed by in situ generated copper sulfide. The pure peptides were isolated in satisfactory yields in less than 5 minutes.
Department of Chemistry, Indian Institute of Science Education and Research, Dr Homi Bhabha Road, Pashan, Pune-411008, India.
Sachitanand M
SM
Mali
Sandip V
SV
Jadhav
Hosahudya N
HN
Gopi
D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000577:Amides; D000588:Amines; D010455:Peptides; D013438:Sulfhydryl Compounds; D003300:Copper; D000432:Methanol