Medicinal flowers. XXXVI.1) Acylated oleanane-type triterpene saponins with inhibitory effects on melanogenesis from the flower buds of Chinese Camellia japonica.
Four acylated oleanane-type triterpene oligoglycosides, sanchakasaponins E-H, were isolated from the flower buds of Camellia japonica cultivated in Yunnan province, China, together with four known triterpene oligoglycosides. The chemical structures of the new triterpene oligoglycosides were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the triterpene oligoglycoside constituents on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells were investigated.
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Japan.
Seikou
S
Nakamura
Katsuyoshi
K
Fujimoto
Souichi
S
Nakashima
Takahiro
T
Matsumoto
Tomoko
T
Miura
Kaoru
K
Uno
Hisashi
H
Matsuda
Masayuki
M
Yoshikawa
D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D028244:Camellia / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D035264:Flowers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008546:Melanoma, Experimental; D000432:Methanol / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D012503:Saponins; D009828:Oleanolic Acid; D000432:Methanol