Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus.
Shampoo therapy is frequently used on pruritic dogs. However, there are few double-blinded, placebo-controlled studies of this form of therapy. This randomised, double-blinded, placebo-controlled study evaluated the efficacy of a commercial medicated shampoo (DermaTopic; Almapharm) containing chlorhexidine, lactoferrin, piroctone olamine, chitosan and essential fatty acids in 27 dogs with mild to moderate allergic pruritus without secondary skin infections. All dogs received shampoo therapy with either DermaTopic or a shampoo vehicle as placebo twice weekly for four weeks. The extent of pruritus was evaluated before the study and then on a daily basis by the owners using a visual analogue scale. Before beginning the treatment and after four weeks, the skin lesions were evaluated by an experienced clinician with a validated lesion score (Canine Atopic Dermatitis Extent and Severity Index - CADESI). The pruritus was reduced significantly by both DermaTopic and placebo. However, there was no significant difference between both groups. There was no statistically significant difference in the CADESI scores pre- and post-treatment in either group or between the two types of treatment. This study provides further evidence of the benefit of shampoo therapy for pruritic dogs.
Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstrasse 13, 80539 Munich, Germany.
J
J
Schilling
R S
RS
Mueller
D000279:Administration, Cutaneous; D000818:Animals; D003876:Dermatitis, Atopic / Q000628:therapy / Q000662:veterinary; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000628:therapy / Q000662:veterinary; D006203:Hair Preparations / Q000627:therapeutic use*; D006969:Hypersensitivity, Immediate / Q000628:therapy / Q000662:veterinary; D008297:Male; D011537:Pruritus / Q000628:therapy / Q000662:veterinary*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D003879:Dermatologic Agents; D006203:Hair Preparations