A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1973 to 2006.
BACKGROUND
Prostate cancer is the most commonly diagnosed malignancy in men in Sweden and Geneva, and the third most common in men in Singapore. This population-based study describes trends in the incidence and mortality rates of prostate cancer in Singapore, Sweden and Geneva (Switzerland) from 1973 to 2006 and explores possible explanations for these different trends.


METHODS
Data from patients diagnosed with prostate cancer were extracted from national cancer registries in Singapore (n = 5,172), Sweden (n = 188,783) and Geneva (n = 5,755) from 1973 to 2006. Trends of incidence and mortality were reported using the Poisson and negative binomial regression models. The age, period and birth-cohort were tested as predictors of incidence and mortality rates of prostate cancer.


RESULTS
Incidence rates of prostate cancer increased over all time periods for all three populations. Based on the age-period-cohort analysis, older age and later period of diagnosis were associated with a higher incidence of prostate cancer, whereas older age and earlier period were associated with higher mortality rates for prostate cancer in all three countries.


CONCLUSIONS
This study demonstrated an overall increase in incidence rates and decrease in mortality rates in Singapore, Sweden and Geneva. Both incidence and mortality rates were much lower in Singapore. The period effect is a stronger predictor of incidence and mortality of prostate cancer than the birth-cohort effect.
Saw Swee Hock School of Public Health, National University of Singapore, 28 Medical Drive, Singapore 11745, Singapore.
Cynthia
C
Chen
Nasheen
N
Naidoo
Qian
Q
Yang
Mikael
M
Hartman
Helena M
HM
Verkooijen
En Yun
EY
Loy
Christine
C
Bouchardy
Kee Seng
KS
Chia
Sin Eng
SE
Chia
D000328:Adult; D000368:Aged; D016010:Binomial Distribution; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D011159:Population Surveillance / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality*; D012042:Registries / Q000706:statistics & numerical data*; D012044:Regression Analysis; D012846:Singapore / Q000453:epidemiology; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology; D013557:Switzerland / Q000453:epidemiology; D013997:Time Factors