Correlation between butyrylcholinesterase variants and sensitivity to soman toxicity.
Butyrylcholinesterase (BChE) is synthesized in the liver and found in high concentrations in blood plasma, liver, heart, pancreas, vascular endothelium, skin, brain white matter, smooth muscle cells and adipocytes. BChE is a non specific enzyme that hydrolyzes different choline esters (succinylcholine, mivacurium) and many other drugs such as aspirin, cocaine and procaine. The enzyme is also considered as a bioscavenger due to its ability to neutralize the toxic effects of organophosphorus compounds (nervous system fs agents) such as soman. BChE displays several polymorphisms that influence its serum activity; therefore they could determine the individual sensitivity to chemical nerve agents. In this study, we investigated the correlation between BChE variants and the degree of enzyme inhibition and reactivation after soman application on blood samples of 726 individuals. The blood samples of individuals expressing abnormal variants, were more sensitive to soman compared to variants of homozygotes and heterozygotes for U-allele. We found significant differences in the degree of enzyme reactivation between different variants (with and without U-presence).
Disaster Medicine and Toxicology Deparment, Military Medical Academy, Sofia, Bulgaria.
Dimo
D
Dimov
Kamen
K
Kanev
Ivanka
I
Dimova
D000328:Adult; D002091:Butyrylcholinesterase / Q000097:blood / Q000235:genetics*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010091:Oximes / Q000494:pharmacology; D011110:Polymorphism, Genetic; D011726:Pyridinium Compounds / Q000494:pharmacology; D012999:Soman / Q000633:toxicity*
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D010091:Oximes; D011726:Pyridinium Compounds; D012999:Soman; D002091:Butyrylcholinesterase; C022870:asoxime chloride