[Neuroprotection in epilepsy].
Brain damage and neuronal loss caused by traumatic brain injury, ischemic stroke, and symptomatic status epilepticus can lead to severe long-term consequences, such as impairment in learning and memory and cognitive functions, and development of chronic epilepsy. This can be the result of morphologic and functional changes underlying temporal lobe epilepsy. Epilepsy patients have increased risk of status epilepticus. It is a life-threatening condition when seizures last for more than 30 min and trigger processes leading to neuronal apoptosis and necrosis in various parts of brain. Administration of neuroprotective drugs preventing these pathologic processes could improve the prognosis for such patients. However despite of active research of neuroprotective drugs, the effective ways to prevent brain damage resulting from prolonged seizures are yet to be found. Studies of neuroprotective properties of classic and novel anticonvulsant drugs showed that most of them do not have the sufficient neuroprotective effect and are not able to prevent epileptogenesis. Thus the studies of other potential neuroprotective drugs seem to be promising.
S A
SA
Chepurnov
E M
EM
Suleĭmanova
M V
MV
Guliaev
K R
KR
Abbasova
Iu A
IuA
Pirogov
N E
NE
Chepurnova
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications*; D016923:Cell Death / Q000502:physiology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D009479:Neuropeptides / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D005894:Panax / Q000737:chemistry; D011859:Radiography; D051381:Rats
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D009479:Neuropeptides; D018696:Neuroprotective Agents