[Genome-wide association study with memory measures as a quantitative trait locus for schizophrenia].
OBJECTIVE
To assess the association between gene polymorphisms and memory function through a genome-wide association study (GWAS) of schizophrenia and control group. Memory cognition was used as a quantitative trait (QT).


METHODS
Ninty-eight subjects with chronic schizophrenia and 60 matched controls were genotyped with HumanHap660 Bead Array. The results were correlated with quantitative traits including memory and memory delay.


RESULTS
Five candidate genes, including RASGRF2 (rs401758, P = 8.03×10(-5)), PLCG2 (rs7185362, P= 4.54×10(-5)), LMO1 (rs484161, P=9.80×10(-7), CSMD1 (rs2469383, P= 2.77×10(-6)) and PRKG1 (rs7898516, P=6.94×10(-5)) were associated with memory cognition deficits.


CONCLUSIONS
Using memory cognition as a quantitative trait, this Genome- wide association study has identified 5 susceptibility loci. With their association with nervous system development, neuronal growth, axon guidance and plasticity, brain development, above loci may play a role in the development of memory dysfunction in schizophrenia.
Psychiatric Laboratory, National Key Laboratory of Biotherapy & Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Bo
B
Xiang
Jun-yao
JY
Wu
Xiao-hong
XH
Ma
Ying-cheng
YC
Wang
Wei
W
Deng
Zhuang-fei
ZF
Chen
Ming-li
ML
Li
Qiang
Q
Wang
Zong-ling
ZL
He
Li-jun
LJ
Jiang
Tao
T
Li
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult