Mobilizing endogenous stem cells for repair and regeneration: are we there yet?
Harnessing endogenous repair mechanisms to promote tissue regeneration in situations in which it does not normally occur has long been a goal in biomedical science. Recent advances in tissue stem cells indicate that this goal may now be achievable. Here we consider both the promise and the hurdles we still have to overcome.
Developmental and Stem Cell Biology Program, Hospital for Sick Children, Toronto M5G 1L7, Canada; McEwen Center for Regenerative Medicine, University of Toronto, Toronto M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1X5, Canada; Department of Physiology, University of Toronto, Toronto M5G 1X5, Canada. Electronic address: fredam@sickkids.ca.
Freda D
FD
Miller
Cell Biology Program, Hospital for Sick Children, Toronto M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5G 1X5, Canada.
David R
DR
Kaplan
D000818:Animals; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*; D014945:Wound Healing