3D hybrid wound devices for spatiotemporally controlled release kinetics.
This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.
Mechanical and Industrial Engineering Department, The University of Iowa, 2130 Seamans Center, Iowa City, IA 52242, USA. ibrahim-ozbolat@uiowa.edu
Ibrahim T
IT
Ozbolat
Bahattin
B
Koc
D000464:Alginates / Q000008:administration & dosage / Q000493:pharmacokinetics; D004058:Diffusion; D016503:Drug Delivery Systems; D004867:Equipment Design; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008962:Models, Theoretical; D010599:Pharmacokinetics; D014945:Wound Healing
D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid