Non-small cell bronchial carcinoma metastasizing into a prolactin-producing pituitary adenoma.
This study presents the case of a 66-year-old man with a non-small cell bronchial carcinoma that metastasized into a prolactin (PRL)-producing pituitary adenoma. The pituitary adenoma cells were immunoreactive for PRL and vascular endothelial growth factor (VEGF). It is hypothesized that VEGF and PRL played a role in the development of metastasis within the adenoma.
Department of laboratory Medicine, Division of Pathology, Toronto, Ontario, Canada. rotondof@smh.ca
Fabio
F
Rotondo
Kalman
K
Kovacs
R Loch
RL
Macdonald
Gerald J
GJ
Prud'homme
Eleanor
E
Latta
David
D
Munoz
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001984:Bronchial Neoplasms / Q000378:metabolism / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000556:secondary*; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000378:metabolism / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D014408:Biomarkers, Tumor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D011388:Prolactin