Involvement of claudins in zebrafish brain ventricle morphogenesis.
Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Jingjing
J
Zhang
Martin
M
Liss
Hartwig
H
Wolburg
Ingolf E
IE
Blasig
Salim
S
Abdelilah-Seyfried
D000818:Animals; D002552:Cerebral Ventricles / Q000196:embryology* / Q000378:metabolism; D057167:Claudins / Q000235:genetics / Q000378:metabolism*; D009024:Morphogenesis; D038081:Organogenesis; D010802:Phylogeny; D019108:Tight Junctions / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism; D029961:Zebrafish Proteins / Q000378:metabolism*
D057167:Claudins; D029961:Zebrafish Proteins