Serum heat shock protein 60 in acute heart failure: a new biomarker?
Heat shock protein 60 (HSP60) is a mitochondrial protein constitutively expressed in the majority of cells, and its expression is up-regulated by a variety of stressors. In heart failure, HSP60 is released from cardiomyocytes. The authors speculate that increased serum HSP60 (sHSP60) may be related to the severity of heart failure. This investigation sought to assess the association between sHSP60 and the composite end point of death/readmission in patients with acute heart failure (AHF). A total of 132 consecutive patients were admitted for AHF. The independent association between sHSP60 and the end point was assessed with Cox regression. During a median follow-up of 7 months (interquartile range, 3-14), 35 (26.5%) deaths, 40 (30.3%) readmissions, and 65 (49.2%) deaths/readmission were identified. Patients who exhibited the outcome showed higher median sHSP60 values (6.15 ng/mL [8.49] vs 4.71 ng/mL [7.55] P=.010). A monotonic increase in the incidence of the composite end point was observed when moving from lower to higher tertile (4.74, 4.76, and 6.98 per 10 patients-years of follow-up, P for trend <.001). After adjusting for established risk factors, only patients in the upper tertile showed an increased risk of death/readmission (hazard ratio, 2.63; 95% confidence interval, 1.29-5.37; P=.008). In patients with AHF, high sHSP60 was related to a higher risk for subsequent death/readmission for AHF.
Cardiology Department, Hospital Clinico Universitario, INCLIVA, Universidad de Valencia, Valencia, Spain. clarabonanad@gmail.com
Clara
C
Bonanad
Julio
J
Núñez
Juan
J
Sanchis
Vicente
V
Bodi
Fabian
F
Chaustre
Marifina
M
Chillet
Gema
G
Miñana
Maria José
MJ
Forteza
Patricia
P
Palau
Eduardo
E
Núñez
David
D
Navarro
Angel
A
Llàcer
Francisco J
FJ
Chorro
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D018834:Chaperonin 60 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
D015415:Biomarkers; D018834:Chaperonin 60