Three-component assembly of conjugated enyne scaffolds via E-selective olefination of ynals.
Benefited by the accessible ynamido-lithium intermediates Ib from a Cu-catalyzed azide-alkyne cycloaddition in the presence of stoichiometric amounts of LiOH, a mild and flexible three-component route to conjugated enyne scaffolds was successfully achieved via a formal E-selective olefination strategy.
Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, People's Republic of China.
Dong
D
Cheng
Fei
F
Ling
Zexiang
Z
Li
Weijun
W
Yao
Cheng
C
Ma
D000475:Alkenes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D015394:Molecular Structure
D000475:Alkenes; D001386:Azides