A combination of ascorbic acid and α-tocopherol or a combination of Mg and Zn are both able to reduce the adverse effects of lindane-poisoning on rat brain and liver.
The purpose of this study, carried out on male Wistar rats, was to evaluate the beneficial effects of supplementation with ascorbic acid (Vit C) and α-tocopherol (Vit E) or with Mg and Zn upon lindane-induced damages in liver and brain. Under our experimental conditions, lindane poisoning (5mg/kg body weight per day for 3 days) resulted in (1) an increased level of plasma glucose, cholesterol and triglycerides, (2) an increased activity of LDH, ALP, AST, ALT, (3) an oxidative stress in liver and brain as revealed by an increased level of lipids peroxidation (TBARS) and a decrease of glutathione-peroxidase, superoxide dismutase and catalase activities in liver and brain. In conclusion, both Vit C+E or Mg+Zn treatments display beneficial effects upon oxidative stress induced by lindane treatment in liver and brain.
Laboratoire d'Ecophysiologie Animale, Sfax, Tunisia. najlaharrathi@yahoo.fr
Najla
N
Hfaiedh
Jean-Claude
JC
Murat
Abdelfettah
A
Elfeki
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D004338:Drug Combinations; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D008099:Liver / Q000187:drug effects*; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D015032:Zinc / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000627:therapeutic use*
D004338:Drug Combinations; D001556:Hexachlorocyclohexane; D024502:alpha-Tocopherol; D008274:Magnesium; D015032:Zinc; D001205:Ascorbic Acid