Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances.
Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Wei-Ye
WY
Liu
Zhi-Bin
ZB
Wang
Li-Chao
LC
Zhang
Xin
X
Wei
Ling
L
Li
D000818:Animals; D001812:Blood-Brain Barrier / Q000033:anatomy & histology / Q000502:physiology* / Q000648:ultrastructure; D057167:Claudins / Q000502:physiology; D003593:Cytoplasm / Q000502:physiology; D004777:Environment; D006728:Hormones / Q000502:physiology; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000502:physiology; D062793:Occludin / Q000502:physiology; D062725:Tight Junction Proteins; D019108:Tight Junctions / Q000502:physiology* / Q000648:ultrastructure*
D057167:Claudins; D006728:Hormones; D019006:Neural Cell Adhesion Molecules; D062793:Occludin; D062725:Tight Junction Proteins