Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+.
The di-copper(II) cation, [Cu(2)(μ-terephthalate)(1,10-phen)(4)](2+), is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.
School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
Andreea
A
Prisecaru
Michael
M
Devereux
Niall
N
Barron
Malachy
M
McCann
John
J
Colleran
Alan
A
Casey
Vickie
V
McKee
Andrew
A
Kellett
D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000737:chemistry
D056831:Coordination Complexes; D010618:Phenanthrolines; D003300:Copper; D004247:DNA; C025205:1,10-phenanthroline