The role of the factor V Leiden mutation in osteonecrosis of the hip.
We examined the hypothesis that the factor V Leiden (FVL) and G20101A prothrombin gene mutations are commonly associated with hip osteonecrosis. We prospectively evaluated 244 consecutively referred adults with osteonecrosis (ON), 161 idiopathic and 83 secondary. Cases (n = 244) did not differ from 104 normal controls by race. Of the 244 patients, 23 (9.4%) were FVL heterozygotes versus 2 of 104 controls (1.9%), P = .013, risk ratio (RR) = 4.90, 95% confidence interval (CI) 1.18 to 20.4. Of the 161 patients with idiopathic ON, 15 (9.3%) were FVL heterozygotes versus 2 of 104 normal controls (1.9%), P = .017, RR = 4.84, 95% CI 1.13 to 20.8. Of the 83 patients with secondary ON, 8 (9.6%) FVL heterozygotes versus 2 of 104 normal controls (1.9%), P = .024, RR = 5.01, 95% CI 1.09 to 23.0. Prothrombin gene heterozygosity in normal controls (2.9%) did not differ from ON cases (3.4%), P = 1.0. The thrombophilic FVL mutation is commonly associated with and may be pathoetiologic for hip osteonecrosis.
1Cholesterol Center, Jewish Hospital of Cincinnati, Cincinnati, OH, USA.
Charles J
CJ
Glueck
Richard A
RA
Freiberg
Gail
G
Boriel
Zia
Z
Khan
Amanpreet
A
Brar
Jagjit
J
Padda
Ping
P
Wang
D000328:Adult; D025861:Blood Coagulation Disorders, Inherited / Q000235:genetics; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D006615:Hip / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010020:Osteonecrosis / Q000097:blood / Q000235:genetics*; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin