Brain structure and spatial sensitivity profile assessing by near-infrared spectroscopy modeling based on 3D MRI data.
The goal of this study is to prove that the light propagation in the head by used the 3-D optical model from in vivo MRI data set can also provide significant characteristics on the spatial sensitivity of cerebral cortex folding geometry based on Monte Carlo simulation. Thus, we proposed a MRI based approach for 3-D brain modeling of near-infrared spectroscopy (NIRS). In the results, the spatial sensitivity profile of the cerebral cortex folding geometry and the arrangement of source-detector separation have being necessarily considered for applications of functional NIRS. The optimal choice of source-detector separation is suggested within 3-3.5 cm by the received intensity with different source-detector separations and the ratio of received light from the gray and white matter layer is greater than 50%. Additionally, this study has demonstrated the capability of NIRS in not only assessing the functional but also detecting the structural change of the brain by taking advantage of the low scattering and absorption coefficients observed in CSF of sagittal view.
Biophotonics and Molecular Imaging Research Center, Institute of Biophotonics, and Biomedical Optical Imaging Lab, National Yang-Ming University, Taipei 11221, Taiwan, ROC.
Ching-Cheng
CC
Chuang
Chung-Ming
CM
Chen
Yao-Sheng
YS
Hsieh
Tsan-Chi
TC
Liu
Chia-Wei
CW
Sun
D000328:Adult; D001921:Brain / Q000166:cytology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D062206:Spatial Analysis; D019265:Spectroscopy, Near-Infrared / Q000379:methods*