Signet-ring-cell carcinoma of stomach metastatic to the bladder: a case report with cytological and histological correlation and literature review.
BACKGROUND
Bladder involvement by a secondary tumor is fairly rare and an uncommon source of bladder metastasis is the stomach.


METHODS
The authors report a case of a 38-year-old man with a bladder metastasis from a gastric signet-ring-cell (SRC) adenocarcinoma who presented with ematuria. The clinical history and the presence of SRCs in the voided urinary cytology and histologically in the suburothelial connective, with an overlying intact urothelium suggested a diagnosis of bladder metastasis from gastric carcinoma.


CONCLUSIONS
Bladder involvement by a secondary tumor is very rare, and a SRC carcinoma metastatic to the bladder, albeit extremely rare, should be considered in the differential diagnosis.
University Federico II of Naples, Naples, Italy. elena@vigliar.it
Elena
E
Vigliar
Gilda
G
Marino
Elide
E
Matano
Ciro
C
Imbimbo
De Cecio
de C
Rossella
Luigi
L
Insabato
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy / Q000556:secondary*; D003581:Cytodiagnosis / Q000379:methods; D017809:Fatal Outcome; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000556:secondary*; D014556:Urine / Q000166:cytology
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil