Stereotactic endoscopic placement of third ventricle catheter for long-term infusion of baclofen in patients with secondary generalized dystonia.
Continuous infusion of baclofen is a treatment option for severe generalized dystonia. Catheter insertion within the third ventricle has been described as an alternative to standard intrathecal placement to maximize intracranial concentrations of baclofen. The authors describe their experience with a novel technique for stereotactic endoscopic insertion of baclofen infusion catheters in the third ventricle in 3 patients with severe secondary generalized dystonia. Insertion was successful in all 3 patients, and all of them experienced significant improvement in dystonia scores on the Barry-Albright Dystonia Scale. Follow-up ranged from 5.5 to 7 months (mean 6 months), and no mechanical complications or CSF leaks were observed. The stereotactic endoscopic insertion of a baclofen infusion catheter into the third ventricle appears to be a safe method for continuous intraventricular baclofen infusion in patients with generalized secondary dystonia.
Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children’s Medical Center, University of Utah, Salt Lake City, Utah 84113, USA.
Robert J
RJ
Bollo
Judith L
JL
Gooch
Marion L
ML
Walker
D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage*; D002408:Catheters, Indwelling; D002648:Child; D002675:Child, Preschool; D020821:Dystonic Disorders / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D044583:Neuroendoscopy / Q000379:methods*; D013238:Stereotaxic Techniques; D020542:Third Ventricle
D009125:Muscle Relaxants, Central; D001418:Baclofen