Implication of high grade intraepithelial neoplasia in adverse pathology after radical prostatectomy.
The implication of high grade prostatic intraepithelial neoplasia (HGPIN)             to prostate cancer aggressiveness and prognosis is conflicted. The aim of the present             study was to evaluate the role of HGPIN in prediction of adverse pathology in             patients undergoing a radical prostatectomy. We retrospectively analysed patients             who underwent a radical prostatectomy between January 2005 and December 2010.             The relationship between HGPIN and the presence of upgrade, positive surgical             margins (PSM), extracapsular disease (ECD), seminal vesicle invasion (SVI) and             lymph node invasion (LNI) was analysed. HGPIN predictive ability was estimated             by using receiver operating characteristic curves. HGPIN was found in 160 (53.3%)             specimens. A statistically significant correlation was found between HGPIN and             preoperative prostate specific antigen (p=0.020) and patients' age (p=0.025). No             significant differences were found, regarding the presence of adverse pathological             findings, between the patients with or without HGPIN, irrespective of the             preoperative risk stratification. HGPIN did not reach significance for the prediction             of upgrade, PSM, ECD, SVI and LNI. The presence of concomitant HGPIN and             prostate cancer found not to be related with tumor aggressiveness in patients             undergoing a radical prostatectomy and should not be considered as a parameter for             the operative outcome prediction.
Department of Urology, University Hospital of Patras, Patras, Greece. sfoungaristosst@gmail.com
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D000368:Aged; D006801:Humans; D008297:Male; D011379:Prognosis; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology / Q000601:surgery*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*