Chemotherapy improves thymoma-associated graft-versus-host-disease-like erythroderma.
Graft-versus-host-disease (GVHD) with erythroderma can rarely occur in the context of thymoma and is associated with a poor prognosis due to an increased risk of infection-related death. The present study describes a case of a 50-year-old man with malignant thymoma who developed sepsis in addition to skin manifestations similar to that seen in GVHD. This patient experienced marked improvement in skin lesions in response to steroids and combination chemotherapy with carboplatin and paclitaxel, with subsequent resolution of infection. The present study describes the clinical course of this patient, followed by a review of pertinent reports of thymoma associated with GVHD with particular focus on the efficacy of treatment strategies.
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tatsuya
T
Nagano
Yoshikazu
Y
Kotani
Kazuyuki
K
Kobayashi
Nanako
N
Tomita
Kyosuke
K
Nakata
Akihiro
A
Sakashita
Yasuhiro
Y
Funada
Hiroshi
H
Nagai
Tomoo
T
Itoh
Yoshihiro
Y
Nishimura
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006086:Graft vs Host Disease / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D013945:Thymoma / Q000150:complications* / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D017239:Paclitaxel; D002945:Cisplatin; D008775:Methylprednisolone