An unusual case of DRESS syndrome due to leflunomide.
The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, is a type of drug hypersensitivity syndrome, is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute hepatic failure. In this article, the authors report a case of DRESS syndrome with severe exfoliative dermatitis with acute hepatitis associated with intake of leflunomide. Rapid diagnosis with withdrawal of offending agent is crucial for survival of these cases.
Department of Internal Medicine, CSM Medical University, Lucknow, Uttar Pradesh, India. vaish12@rediffmail.com
Arvind Kumar
AK
Vaish
Anil Kumar
AK
Tripathi
Lokesh Kumar
LK
Gupta
Nirdesh
N
Jain
Abhishek
A
Agarwal
Sudhir Kumar
SK
Verma
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002180:Candidiasis, Oral / Q000139:chemically induced; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D000077339:Leflunomide; D008297:Male; D013577:Syndrome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D000077339:Leflunomide