Transmission, attenuation and reflection of shear waves in the human brain.
Traumatic brain injuries (TBIs) are caused by acceleration of the skull or exposure to explosive blast, but the processes by which mechanical loads lead to neurological injury remain poorly understood. We adapted motion-sensitive magnetic resonance imaging methods to measure the motion of the human brain in vivo as the skull was exposed to harmonic pressure excitation (45, 60 and 80 Hz). We analysed displacement fields to quantify the transmission, attenuation and reflection of distortional (shear) waves as well as viscoelastic material properties. Results suggest that internal membranes, such as the falx cerebri and the tentorium cerebelli, play a key role in reflecting and focusing shear waves within the brain. The skull acts as a low-pass filter over the range of frequencies studied. Transmissibility of pressure waves through the skull decreases and shear wave attenuation increases with increasing frequency. The skull and brain function mechanically as an integral structure that insulates internal anatomic features; these results are valuable for building and validating mathematical models of this complex and important structural system.
Department of Mechanical Engineering and Materials Science, Washington University in St Louis, One Brookings Drive, Campus Box 1185, St Louis, MO 63130, USA. clayton@wustl.edu
Erik H
EH
Clayton
Guy M
GM
Genin
Philip V
PV
Bayly
D001696:Biomechanical Phenomena; D001930:Brain Injuries / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009038:Motion; D011312:Pressure; D012886:Skull / Q000503:physiopathology*