Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption.
The authors describe an HIV-positive patient with nodular regenerative hyperplasia of the liver with non-cirrhotic portal hypertension. Despite stopping the culprit drug, didanosine, the radiologic changes persisted for years. When evaluating liver pathologies, antiretroviral drugs must be included in the differential diagnosis, even when they have been stopped years ago.
Medical School, University of Zurich, Zurich, Switzerland.
Daniel
D
Hofmaenner
Helen
H
Kovari
Achim
A
Weber
Dominik
D
Weishaupt
Roberto F
RF
Speck
D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016049:Didanosine / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D006965:Hyperplasia; D006975:Hypertension, Portal / Q000139:chemically induced; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013997:Time Factors
D019380:Anti-HIV Agents; D016049:Didanosine