Eosinophilic esophagitis after esophageal atresia: is there an association? Case presentation and literature review.
Eosinophilic esophagitis (EoE) is a relatively new condition resulting in dysphagia or symptoms resembling gastroesophageal reflux disease, symptoms that also are common in patients with a history of esophageal atresia. We present 2 patients with persistent dysphagia after repair of esophageal atresia that was caused by EoE. Although the exact etiology and pathogenesis of EoE remain unclear, it is now generally accepted that it is the result of a T-helper cell 2-type immune response with a crucial role for the eosinophil-specific chemotaxis factor eotaxin 3 and eosinophils. Because there are genetic similarities between esophageal atresia and EoE, we speculate that patients with esophageal atresia are at increased risk for developing EoE.
Paediatric Surgical Center of Amsterdam, Emma Children's Hospital and VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
Ramon R
RR
Gorter
Hugo A
HA
Heij
J Patrick
JP
van der Voorn
C M Frank
CM
Kneepkens
D000015:Abnormalities, Multiple / Q000601:surgery; D001003:Anal Canal / Q000002:abnormalities; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000209:etiology; D000075906:Chemokine CCL26; D019742:Chemokines, CC / Q000276:immunology; D002648:Child; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000209:etiology; D004198:Disease Susceptibility; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D004933:Esophageal Atresia / Q000150:complications / Q000235:genetics / Q000601:surgery*; D004941:Esophagitis / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D004947:Esophagus / Q000002:abnormalities; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000150:complications / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000235:genetics; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D017353:Gene Deletion; D006330:Heart Defects, Congenital; D006551:Hernia, Hiatal / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D017880:Limb Deformities, Congenital; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D013131:Spine / Q000002:abnormalities; D018418:Th2 Cells / Q000276:immunology; D014132:Trachea / Q000002:abnormalities; D014138:Tracheoesophageal Fistula / Q000601:surgery
D000897:Anti-Ulcer Agents; C120429:CCL26 protein, human; D000075906:Chemokine CCL26; D019742:Chemokines, CC; D051858:Forkhead Transcription Factors