Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA. irfan_rahman@urmc.rochester.edu
Irfan
I
Rahman
Vuokko L
VL
Kinnula
D000975:Antioxidants / Q000378:metabolism; D002986:Clinical Trials as Topic; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D001239:Inhalation / Q000187:drug effects; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000503:physiopathology; D012906:Smoke / Q000009:adverse effects*; D012907:Smoking / Q000009:adverse effects*
D000975:Antioxidants; D005609:Free Radicals; D016877:Oxidants; D012906:Smoke