Hair dye related acute kidney injury--a clinical and experimental study.
We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats the renal lesions were noted in all and they were glomerular congestion, intertubular (interstitial) hemorrhages, acute tubular necrosis, mesangial proliferation, and intratubular casts. The severity of renal injury appears to be dose dependent.
Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
Yanala
Y
Sandeep Reddy
Shaik
S
Abbdul Nabi
Chippada
C
Apparao
Chinthamaneni
C
Srilatha
Yadla
Y
Manjusha
Parvathina
P
Sri Ram Naveen
Chennu
C
Krishna Kishore
Anappindi
A
Sridhar
Vishnubotla
V
Siva Kumar
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D000818:Animals; D005260:Female; D006202:Hair Dyes / Q000506:poisoning*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010655:Phenylenediamines / Q000506:poisoning*; D051381:Rats; D055815:Young Adult
D006202:Hair Dyes; D010655:Phenylenediamines; C029728:4-phenylenediamine