Invasive pneumonia and septic shock in infants as a presentation of cystic fibrosis with vitamin-deficiency.
Herein we describe three infants with the rare presentation of pneumonia with septic shock as their initial medical encounter leading to the diagnosis of cystic fibrosis (CF). At the time of their presentation all three children had significant nutritional deficiency. We initiated an aggressive treatment regimen including nutritional supplementation which resulted in improvement in their pulmonary status and no further recurrences. This series highlights the possible presentation of CF in infancy as a life-threatening invasive infection of Staphylococcus aureus or Pseudomonas aeruginosa. It also supports neonatal screening and emphasizes the role of early attention to nutritional status and vitamin supplementation.
Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. enfantsdoc@gmail.com
Eman S
ES
Al-Khadra
Kin-wai
KW
Chau
Cara Pizzo
CP
Barone
Andrew A
AA
Colin
D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001361:Avitaminosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D002442:Ceftazidime / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications* / Q000175:diagnosis* / Q000382:microbiology; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014031:Tobramycin / Q000627:therapeutic use; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002442:Ceftazidime; D014031:Tobramycin