UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
OBJECTIVE
To test whether the genetic polymorphisms within the gene encoding the UGT2B7 gene may have an impact on methadone treatment.


METHODS
Twelve SNPs in UGT2B7 were selected. 366 methadone maintenance treatment patients in Taiwan were recruited and genotyped.


RESULTS
In a genotype recessive model, rs6600879, rs6600880, rs4554144, rs11940316, rs7438135, rs7662029, rs7668258, rs7439366, rs4292394 and rs6600893 showed significant associations with severity of withdrawal symptoms (permutation p < 0.002), pupil size (permutation p < 0.048) and tremor (permutation p < 0.008). Haplotypes of GATCAGCCGC and CTCTGATTCT were significantly associated with pupil size score and tremor score (p < 0.034).


CONCLUSIONS
These results suggest that SNPs of the UGT2B7 gene may play important roles in opiate withdrawal symptoms.
Division of Mental Health & Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan.
Jia-Ni
JN
Tian
Ing-Kang
IK
Ho
Hsiao-Hui
HH
Tsou
Chiu-Ping
CP
Fang
Chin-Fu
CF
Hsiao
Chia-Hui
CH
Chen
Happy Kuy-Lok
HK
Tan
Linen
L
Lin
Chi-Shin
CS
Wu
Lien-Wen
LW
Su
Chieh-Liang
CL
Huang
Yi-Hong
YH
Yang
Ming-Lun
ML
Liu
Yu-Ting
YT
Chen
Shu Chih
SC
Liu
Ya-Ting
YT
Hsu
Hsiang-Wei
HW
Kuo
Chen Ting
CT
Liu
Yi-Ting
YT
Yang
Andrew Ch
ACh
Chen
Yu-Huei
YH
Shih
Yu-Li
YL
Liu
D000328:Adult; D000639:Amitriptyline / Q000097:blood; D005260:Female; D056726:Genetic Association Studies; D014453:Glucuronosyltransferase / Q000235:genetics*; D006239:Haplotypes; D006556:Heroin Dependence / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D008875:Middle Aged; D009020:Morphine / Q000097:blood / Q000652:urine; D020641:Polymorphism, Single Nucleotide; D011759:Pyrrolidines / Q000097:blood; D013375:Substance Withdrawal Syndrome / Q000235:genetics* / Q000473:pathology; D013624:Taiwan
D011759:Pyrrolidines; D000639:Amitriptyline; D009020:Morphine; C491474:UGT2B7 protein, human; D014453:Glucuronosyltransferase; D008691:Methadone; C010724:2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine