[Na+, K(+)-ATPase, endogenous cardiotonic steroids and their transducing role].
Na+, K(+)-ATPase--a protein complex of plasmatic membrane, which performs the dual function: firstly, it supports the Na+ and K+ homeostasis, and also transmembrane potential gradient, secondly, it serves as the transducer of signals and as the regulator of the expression of many key genes. Endogenous cardiotonic steroids, which are synthesized in the adrenal glands and hypothalamus, serve as the signal molecules. New concepts about the mechanisms of the realization of the Na+, K(+)-ATPase signal function and their connection with cellular functions, apoptosis, and with pathologies of cardiovascular system and water-salt homeostasis are described in the survey.
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Tsymbaliuk
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Kosterin
D000311:Adrenal Glands / Q000378:metabolism / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D002298:Cardenolides / Q000378:metabolism*; D002301:Cardiac Glycosides / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000503:physiopathology; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D032383:Myocytes, Cardiac / Q000166:cytology / Q000201:enzymology*; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000378:metabolism*
D002298:Cardenolides; D002301:Cardiac Glycosides; D021122:Protein Subunits; D000254:Sodium-Potassium-Exchanging ATPase