[Oxydative stress and beneficial effect of sodium restriction on kidney damage associated with insulin resistance in rats].
The aim of this work was to evaluate the influence of dietary sodium restriction on metabolic and renal changes associated with insulin resistance. At 8 weeks of age, rats received either a diet containing 60% fructose with or without sodium or a standard diet for 12 weeks. The insulin resistance and albuminuria induced by the high fructose diet were associated with a fibrosis and increase in oxidative stress in the kidney. The low salt diet prevented insulin resistance, renal fibrosis and albuminuria induced by the fructose diet. These beneficial effects on the kidney were associated with a decrease in kidney NADPH oxidase activity. Oxidative status is probably one of the major targets of the favourable effect of salt restriction on renal changes associated with insulin resistance, without excluding the involvement of other mechanisms.
Centre de pharmacologie et innovation dans le diabète, FRE 3400 Montpellier, université de Montpellier, 34093 Montpellier, France.
C
C
Oudot
A-D
AD
Lajoix
B
B
Jover
C
C
Rugale
D000419:Albuminuria / Q000517:prevention & control*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D004195:Disease Models, Animal; D005355:Fibrosis; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects*; D007333:Insulin Resistance; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009249:NADP / Q000378:metabolism; D019255:NADPH Oxidases / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage / Q000009:adverse effects
D001786:Blood Glucose; D017673:Sodium Chloride, Dietary; D005632:Fructose; D009249:NADP; D019255:NADPH Oxidases