[Structural changes in heart at experimental widespread purulent peritonitis].
Structural changes in the heart are studied at an experimental widespread purulent peritonitis. It was established that in 6 hours after initiation of peritonitis in a myocardium the severe disorders of blood circulation, interstitial edema, the phenomena of kariopyknosis, development of systemic toxic damages specifying in high speed at this disease were observed. One of the mechanism of their development is a energy deficiency. The proof of this is destructive changes of cardiomyocytes mitochondria. The comparative analysis of use of metabolic preparations "Citoflavin", containing amber acid, and "Neoton", containing phosphocreatine, for the purpose of pharmacological support of cardiac activity at an experimental widespread purulent peritonitis has revealed high efficiency of the preparation "Citoflavin". It caused more intensive decrease of inflammatory changes in a myocardium, preventing of cardiomyocytes necrobiosis, contribution to preservation of normal structure and growth of quantity of mitochondria.
V A
VA
Kosinets
I V
IV
Samsonova
E L
EL
Ryzhkovskaia
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage; D004195:Disease Models, Animal; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D058958:Organs at Risk; D010538:Peritonitis / Q000139:chemically induced / Q000150:complications / Q000378:metabolism; D010725:Phosphocreatine / Q000008:administration & dosage*; D010784:Photomicrography / Q000379:methods; D011817:Rabbits; D012720:Severity of Illness Index; D013492:Suppuration / Q000209:etiology / Q000378:metabolism; D016896:Treatment Outcome
D002316:Cardiotonic Agents; D010725:Phosphocreatine