Cerebral venous sinus thrombosis: association with primary varicella zoster virus infection.
Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy and an acquired antibody-mediated coagulopathy associated with purpura fulminans and generalized thromboembolism. There are no published reports of cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We report 2 cases that highlight an unusual presentation of VZV infection: CVST with primary varicella infection. One patient had extensive CVST with coexistent middle cerebral artery involvement. Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses.
Department of Neurology, Infectious Diseases, Medicine and Radiology, Aga Khan University, Karachi, Pakistan.
Shaista Anwar
SA
Siddiqi
Sadia
S
Nishat
Durreshahwar
D
Kanwar
Farheen
F
Ali
Muhammad
M
Azeemuddin
Mohammad
M
Wasay
D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002533:Cerebral Angiography / Q000379:methods; D002536:Cerebral Arteries / Q000473:pathology / Q000821:virology*; D038524:Diffusion Magnetic Resonance Imaging; D006562:Herpes Zoster / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000821:virology; D018810:Magnetic Resonance Angiography; D008297:Male; D010690:Phlebography / Q000379:methods; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D016896:Treatment Outcome; D055815:Young Adult
D000925:Anticoagulants; D000998:Antiviral Agents