[Scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro].
OBJECTIVE
To study scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro.


METHODS
The Franz diffusion cell method was used to experiment the permeability test (n = 4), taking fresh nasal mucosa of dog, swine and domestica in vitro as permeation barrier separately, with scutellarin starch microspheres (scutellarin 0.25 mg) above them, and blank pH 6.8 PBS as absorption liquid to detemine the scutellarin by HPLC.


RESULTS
The permeability coefficient of scutellarin starch microspheres through nasal mucosa of dog, swine and domestica in vitro were (5.295 +/- 0.637) x 10(-3) (4.065 +/- 1.140) x 10(-3), (1.855 +/- 0.150) x 10(-3) cm x mL(-1) separately. The permeability coefficient order of scutellarin starch microspheres through nasal mucosa of different animals in vitro is dog > swine > domestica, and there are significant differences between the permeability coefficient of scutellarin starch microspheres through nasal mucosa of dog, swine in vitro, and that through nasal mucosa of swine and domestica in vitro.


CONCLUSIONS
Drugs in scutellarin starch microspheres could permeate through the above-mentioned nasal mucosa in vitro. There might be different permeability coefficient among different species.
jinhua People's Hospital, Jinhua 321000, China. yeshh9282@126.com
Shanghe
S
Ye
Xiaoling
X
Song
Changyu
C
Li
Weihong
W
Ge
Senlin
S
Shi
D000818:Animals; D047310:Apigenin / Q000493:pharmacokinetics*; D004285:Dogs; D005965:Glucuronates / Q000493:pharmacokinetics*; D008863:Microspheres; D009297:Nasal Mucosa / Q000378:metabolism*; D010539:Permeability; D013213:Starch / Q000493:pharmacokinetics*; D013552:Swine; D013556:Swine, Miniature
D005965:Glucuronates; C484876:scutellarin; D047310:Apigenin; D013213:Starch