Neurological soft signs in persons with amnestic mild cognitive impairment and the relationships to neuropsychological functions.
BACKGROUND
Neurological abnormalities have been reported in people with amnestic mild cognitive impairment (aMCI). The current study aimed to examine the prevalence of neurological soft signs (NSS) in this clinical group and to examine the relationship of NSS to other neuropsychological performances.


METHODS
Twenty-nine people with aMCI and 28 cognitively healthy elderly people were recruited for the present study. The NSS subscales (motor coordination, sensory integration, and disinhibition) of the Cambridge Neurological Inventory and a set of neuropsychological tests were administered to all the participants.


RESULTS
People with aMCI exhibited significantly more motor coordination signs, disinhibition signs, and total NSS than normal controls. Correlation analysis showed that the motor coordination subscale score and total score of NSS were significantly inversely correlated with the combined Z-score of neuropsychological tests in aMCI group.


CONCLUSIONS
These preliminary findings suggested that people with aMCI demonstrated a higher prevalence of NSS compared to healthy elderly people. Moreover, NSS was found to be inversely correlated with the neuropsychological performances in persons with aMCI. When taken together, these findings suggested that NSS may play a potential important role and serve as a tool to assist in the early detection of aMCI.
Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Hui-Jie
HJ
Li
Peng-Yun
PY
Wang
Yang
Y
Jiang
Raymond C K
RC
Chan
Hua-Li
HL
Wang
Juan
J
Li
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000523:psychology*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009048:Motor Skills; D009460:Neurologic Examination; D009483:Neuropsychological Tests