Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease.
We studied the number and function of angiogenic progenitor cells and growth factors in children aged 5-18 years without acute illness, 43 with Hemoglobin SS and 68 with normal hemoglobin. Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor cell than Control subjects. Plasma concentrations of erythropoietin, angiopoietin-2, and stromal-derived growth factor (SDF)-1α were significantly higher in children with Hemoglobin SS compared to Control subjects. In a multivariate analysis model, SDF-1α concentration was found to be associated with both CPC number and total white blood cell count in the Hemoglobin SS group, suggesting that SDF-1α produced by ischemic tissues plays a role in mobilizing these cells in children with Hemoglobin SS. Despite having a higher number of angiogenic progenitor cells, children with Hemoglobin SS had slower migration of cultured mononuclear cells.
Department of Pediatrics, Division of Hematology/Oncology, Emory University School of Medicine, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USA.
Solomon F
SF
Ofori-Acquah
Iris D
ID
Buchanan
Ifeyinwa
I
Osunkwo
Jerry
J
Manlove-Simmons
Feyisayo
F
Lawal
Alexander
A
Quarshie
Arshed A
AA
Quyyumi
Gary H
GH
Gibbons
Beatrice E
BE
Gee