Hydatidiform mole in Turkey: results from six centers.
OBJECTIVE
To evaluate the clinical profile of gestational trophoblastic disease and to determine the incidence of hydatidiform mole (HM) from six centers in Turkey.


METHODS
A retrospective analysis of patients diagnosed with HM in six medical centers in Turkey from 2000 to 2010 was undertaken. Patients' age, gravidity, parity and abortion, presenting signs, histopathological results and their follow-up were recorded.


RESULTS
From 2000 to 2010, 351,650 deliveries were recorded in six centers in Turkey, and 263 cases were diagnosed as HMs. Of the 263 patients the mean age was 28.2 years. The mean numbers of gravidity, parity and abortion were 2.6, 1.3 and 0.3, respectively. According to the medical histories, 3 (1.1%) patients had molar pregnancy previously and the presenting symptom was vaginal bleeding in symptomatic cases. After evacuation, histopathologic examination revealed complete mole in 175 (66.5%) patients and partial mole in 86 (32.6%) patients, and methotrexate was given as a prophylactic chemotherapy in 17 patients (6.4%) while 6 (2.2%) patients underwent hysterectomy procedure.


CONCLUSIONS
According to the results the incidence of molar pregnancy is 0.7/1,000 deliveries. Because of its rarity, multicenter, community-based studies are needed to determine the real incidence.
Department of Obstetrics and Gynecology, Eskisehir Osmangazi University School of Medicine, Eskisehir; Zekai Tahir Burak Maternity and Gynecology Training and Research Hospital, Ankara, Turkey. tufanoge@yahoo.com
Tufan
T
Oge
S Sinan
SS
Ozalp
Tayfun
T
Güngör
Yusuf
Y
Yildirim
Muzaffer
M
Sanci
Askin
A
Dogan
I Egemen
IE
Ertas
Hakan
H
Yetimalar
Saffet
S
Dilek
Cetin
C
Celik
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D020073:Gravidity; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D007044:Hysterectomy; D008727:Methotrexate / Q000008:administration & dosage; D010298:Parity; D011247:Pregnancy; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D014592:Uterine Hemorrhage; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy
D000970:Antineoplastic Agents; D006063:Chorionic Gonadotropin; D008727:Methotrexate