Long-term clinical evaluation of platelet-rich plasma in the treatment of human periodontal intraosseous defects: A comparative clinical trial.
OBJECTIVE
To compare the long-term clinical outcomes obtained by the combination of platelet-rich plasma (PRP) and a porous hydroxyapatite at the test site with those obtained from the use of a mixture of hydroxyapatite and saline at the control site in the treatment of human intraosseous defects.


METHODS
Sixty healthy, nonsmoking subjects diagnosed with chronic periodontitis were included in this study. Using a split-mouth design, intraosseous defects were surgically treated with a combination of PRP and a porous hydroxyapatite or a mixture of hydroxyapatite and saline. Clinical measurements and radiographic evaluation were performed at baseline and 1 and 4 years postoperatively.


RESULTS
When compared with baseline, the 1-year results showed no significant changes. However, the 4-year results indicated that while both treatment modalities resulted in significant changes in all clinical parameters (probing depth, relative attachment level, gingival recession, and intraosseous defect fill; P < .001), the test group exhibited statistically significant changes compared with the control group: probing depth reduction, 5.8 ± 0.49 mm vs 4.0 ± 0.45 mm (P < .0001); clinical attachment gain, 5.4 ± 1.2 mm vs 3.1 ± 1.1 mm (P < .0001); and defect fill, 3.2 ± 0.8 mm vs 2.1 ± 0.6 mm (P < .0001).


CONCLUSIONS
Treatment with a combination of PRP and hydroxyapatite compared with hydroxyapatite with saline led to a significantly more favorable clinical improvement in intraosseous periodontal defects.
Department of Periodontology, Government Dental College and Hospital, Bambolim, India. applegate2k@yahoo.com
Lilian Maria
LM
Menezes
Jyoti
J
Rao
D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D055113:Chronic Periodontitis / Q000601:surgery*; D017886:Durapatite; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma / Q000502:physiology; D016037:Single-Blind Method
D018786:Bone Substitutes; D017886:Durapatite