Protective effect of Tribulus terrestris linn on liver and kidney in cadmium intoxicated rats.
Administration of cadmium (Cd) significantly increased the peroxidation markers such as malondialdehyde and protein carbonyls along with significant decrease in antioxidant markers such as super oxide dismutase and reduced glutathione in liver and kidney tissues. Cadmium also caused a significant alteration in hepatic and renal functional markers in serum viz. total protein, albumin, alanine transaminase, blood urea nitrogen and creatinine. Prominent pathological changes observed in liver were severe vascular and sinusoidal congestion with diffuse degenerative changes and mononuclear infiltration into peripheral areas, while the kidney showed vascular and glomerular congestion, cloudy swelling of tubular epithelium. Coadministration of ethonolic extract of T. terrestris or vitamin E along with Cd significantly reversed the Cd induced changes along with significant reduction in Cd load.
Department of Pharmacology & Toxicology, NTR College of Veterinary Science, Gannavaram 521 102, India.
G Dhana
GD
Lakshmi
P Ravi
PR
Kumar
K
K
Bharavi
P
P
Annapurna
B
B
Rajendar
Pankaj T
PT
Patel
C S V Satish
CS
Kumar
G S
GS
Rao
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D000431:Ethanol; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D032444:Tribulus / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects
D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D020011:Protective Agents; D002104:Cadmium; D000431:Ethanol