Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium.
Homeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.
Department of Gastroenterology & Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
Nikè V J A
NV
Büller
Sanne L
SL
Rosekrans
Jessica
J
Westerlund
Gijs R
GR
van den Brink
D000818:Animals; D049109:Cell Proliferation; D053823:Hedgehog Proteins / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D053823:Hedgehog Proteins