Exploring the effect of sialic acid orientation on ligand-receptor interactions.
Here, we present the synthesis of two sialo-micelles to validate the significance of sialic acid orientation during specific carbohydrate-protein and carbohydrate-carbohydrate interactions. Our data clearly suggest that orientation of carboxylic acid and glycerol side chains of sialic acid moieties exert fine tuning of ligand-receptor interactions.
Indian Institute of Science Education and Research, Sai Trinity Building, Pashan, Pune 411021, India.
Rohan
R
Yadav
Raghavendra
R
Kikkeri
D000818:Animals; D001665:Binding Sites; D016466:CHO Cells; D002241:Carbohydrates / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D006224:Cricetinae; D003412:Cricetulus; D005990:Glycerol / Q000737:chemistry; D008024:Ligands; D008823:Micelles; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000737:chemistry / Q000378:metabolism
D002241:Carbohydrates; D002264:Carboxylic Acids; D008024:Ligands; D008823:Micelles; D051918:Sialic Acid Binding Ig-like Lectin 2; D019158:N-Acetylneuraminic Acid; D005990:Glycerol