Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients.
The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. elizabeth_yanik@med.unc.edu
Elizabeth L
EL
Yanik
Sonia
S
Napravnik
Christopher B
CB
Hurt
Ann
A
Dennis
E Byrd
EB
Quinlivan
Joe
J
Sebastian
Joann D
JD
Kuruc
Joseph J
JJ
Eron
D000208:Acute Disease; D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002908:Chronic Disease; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000635:transmission* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood
D044966:Anti-Retroviral Agents; D012367:RNA, Viral