[Control and analysis of cells by synthetic small molecules].
In human history, small organic molecules have been utilized for improving human health and for revealing secrets of life. Discovery or design of small organic molecules with unique biological activity permits small-molecule-initiated exploration of biology. Our laboratory has been discovering and designing bioactive small synthetic molecules to use them as tools to analyze or modulate biological processes. This personal perspective summarizes our contributions to chemical biology, particularly in the fields of gene transcription, cell therapy, growth factor signaling, and target identification.
Institutes for Integrated Cell-Material Sciences and for Chemical Research, Kyoto University, Japan. uesugi@scl.kyoto-u.ac.jp
Motonari
M
Uesugi
D000218:Adamantane; D000818:Animals; D001578:Benzopyrans / Q000737:chemistry; D064987:Cell- and Tissue-Based Therapy; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008967:Molecular Biology; D008968:Molecular Conformation; D008970:Molecular Weight; D010879:Piperazines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D015398:Signal Transduction; D013449:Sulfonamides; D013844:Thiazoles / Q000737:chemistry; D014158:Transcription, Genetic
D001578:Benzopyrans; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins; C561240:N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide; D010879:Piperazines; D011725:Pyridines; D013449:Sulfonamides; D013844:Thiazoles; C474394:adamanolol; C549555:adhesamine; C560188:chromeceptin; C545733:fatostatin; D000218:Adamantane