Thyroid disorders during pregnancy.
Thyroid physiology is altered during pregnancy as a result of an increase in thyroid-binding globulin, the stimulatory effect of hCG on TSH receptors, and increased peripheral thyroid hormone requirements. In addition, hyper and hypothyroid disorders are prevalent among women of reproductive age, and most of them have a significant impact on the gravida, fetus and neonate. Aberrant thyroid function can be readily recognized and treated during pregnancy, avoiding such complications. Here, we will review the thyroid function changes occurring during pregnancy, the different disorders, their maternal and fetal implications, and the ways to screen, prevent and treat these conditions.
Department of OB & GYN, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Ilana L
IL
Parkes
Joseph G
JG
Schenker
Yoel
Y
Shufaro
D000818:Animals; D003409:Congenital Hypothyroidism / Q000517:prevention & control; D005260:Female; D006111:Graves Disease / Q000151:congenital / Q000517:prevention & control; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D007037:Hypothyroidism / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011296:Prenatal Diagnosis; D013959:Thyroid Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013961:Thyroid Gland / Q000503:physiopathology*