Glaucoma progression in eyes with a history of refractive corneal surgery.
OBJECTIVE
To evaluate the glaucoma progression in patients with a history of refractive corneal surgery (RCS).


METHODS
A total of 313 eyes of 313 glaucoma patients (RCS group, 34 eyes; non-RCS group, 279 eyes) with a mean follow-up period of 2.7 years were included. Glaucoma progression was determined either by experts' stereoscopic optic disc/retinal nerve fiber layer (RNFL) photographs or by serial visual field (VF) data. Uni- and multivariate Cox's proportional hazards models were used to determine associations between potential risk factors including a history of RCS and glaucoma progression.


RESULTS
Among 313 eyes, 87 (27.8%) eyes showed progression either by optic disc/RNFL photographs or VF assessment during the follow-up period. Ten (29.4%) of eyes in the RCS group and 77 (27.6%) of eyes in the non-RCS group showed glaucoma progression; however, prevalence of progression did not differ between the two groups (P = 0.482). Among all participants, baseline age and VF pattern standard deviation (PSD; hazard ratios of 1.013 and 1.119; P = 0.026 and P < 0.001, respectively) were significant risk factors for progression. In both the RCS and the non-RCS group, only VF PSD was a significant risk factor for progression according to multivariate Cox proportional hazards (1.193, 1.099, P < 0.001, P < 0.001, respectively).


CONCLUSIONS
Baseline VF PSD and age substantially affected glaucoma progression in all study participants, although their RCS history was not a significant risk factor for glaucoma progression.
Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Yoon Jeon
YJ
Kim
Sung-Cheol
SC
Yun
Jung Hwa
JH
Na
Hung Won
HW
Tchah
Jong Jin
JJ
Jung
Kyung Rim
KR
Sung
D000328:Adult; D048988:Corneal Surgery, Laser; D018450:Disease Progression; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D016016:Proportional Hazards Models; D012165:Retinal Ganglion Cells / Q000473:pathology; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology