Endometrial carcinoma tumorigenesis and pharmacotherapy research.
Endometrial carcinoma is the common malignant tumor of the female genital tract, and its incidence is increasing. Two different clinicopathological subtypes are recognized based on epidemiology, genetic carcinogenesis and clinical behavior. Understanding and identifying molecular biology and genetics is essential to the development of novel therapies. This article reviews the current understanding of its risk factors, recent conceptions on its tumorigenesis and advances on its drug therapies.
School of Medicine, Zhejiang University, Hangzhou, China.
J
J
Shu
S
S
Fang
P G
PG
Teichman
L
L
Xing
H
H
Huang
D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002986:Clinical Trials as Topic; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D004967:Estrogens / Q000009:adverse effects / Q000502:physiology; D005260:Female; D006801:Humans; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D009376:Neoplasms, Hormone-Dependent / Q000453:epidemiology / Q000209:etiology; D009765:Obesity / Q000150:complications / Q000378:metabolism; D011374:Progesterone / Q000172:deficiency / Q000502:physiology; D012307:Risk Factors
D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D052246:Cyclooxygenase 2 Inhibitors; D004967:Estrogens; D009363:Neoplasm Proteins; D011374:Progesterone; D008687:Metformin