Effect of parenteral fish oil lipid emulsion in parenteral nutrition supplementation combined with enteral nutrition support in patients undergoing pancreaticoduodenectomy.
BACKGROUND
The effect of parenteral fish oil lipid emulsion in parenteral nutrition (PN) supplementation combined with enteral nutrition (EN) support on pancreaticoduodenectomy (PD) was investigated with a randomized controlled clinical trial at the Affiliated Drum Tower Hospital.


METHODS
Seventy-six patients who underwent PD in the Department of Hepatobiliary Surgery were randomly divided into 2 groups: the polyunsaturated fatty acid (PUFA) group (n = 38) and control group (n = 38). Patients in the PUFA group received parenteral fish oil lipid emulsion supplementation combined with early EN support for 5 days after PD. Venous blood samples were obtained for assay on the day before surgery and on day 6 after surgery.


RESULTS
Compared with the results of the control group, a significant difference was seen in the extent of the decrease in total protein and prealbumin in the PUFA group (P < .05). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were significantly decreased on day 6 in the PUFA group (P < .01), and a significant difference was seen in the extent of decrease in ALT, AST, and LDH in the PUFA group (P < .05). The ratio of infectious complications in the PUFA group was significantly decreased, as well as the postoperative hospital stay (P < .05), and there was no hospital mortality in this study.


CONCLUSIONS
Parenteral fish oil lipid emulsion in PN supplementation combined with EN support can greatly improve the nutrition state and liver function of patients, decrease the incidence of infectious morbidities, and shorten the postoperative hospital stay.
Medical School of Nanjing University, Nanjing, China.
Xinhua
X
Zhu
Yafu
Y
Wu
Yudong
Y
Qiu
Chunping
C
Jiang
Yitao
Y
Ding
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D003428:Cross Infection / Q000517:prevention & control; D004041:Dietary Fats / Q000494:pharmacology / Q000627:therapeutic use; D019587:Dietary Supplements; D004750:Enteral Nutrition / Q000379:methods*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology / Q000627:therapeutic use*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology / Q000627:therapeutic use*; D005395:Fish Oils / Q000494:pharmacology / Q000627:therapeutic use*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007902:Length of Stay; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009752:Nutritional Status / Q000187:drug effects; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D010288:Parenteral Nutrition / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D011228:Prealbumin / Q000378:metabolism
D001798:Blood Proteins; D004041:Dietary Fats; D005217:Fat Emulsions, Intravenous; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D011228:Prealbumin; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase