Immune factors in breast milk and the development of atopic disease.
Breast-feeding provides protection against infections and contains numerous factors that modulate and promote the development of the infant immune system. These factors include secretory IgA, antimicrobial proteins like CD14, cytokines, and fatty acids. Studies examining the role of breast-feeding in the development of allergic disease in infants demonstrate potentially protective as well as neutral or nonprotective effects, likely due to the heterogeneity in their study design. In this overview, we explore the potential role of immune factors in the breast milk, as well as selected probiotics, in the development of allergy.
Pediatric Allergy/Immunology Division, Massachusetts General Hospital for Children, Boston, MA, USA. riyengar@partners.org
Shuba R
SR
Iyengar
W A
WA
Walker
D001942:Breast Feeding; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology / Q000517:prevention & control; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000517:prevention & control; D007107:Immune System / Q000254:growth & development*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007155:Immunologic Factors / Q000378:metabolism*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008895:Milk, Human / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D005227:Fatty Acids; D007071:Immunoglobulin A, Secretory; D007155:Immunologic Factors; D018950:Lipopolysaccharide Receptors