Distinct roles of central and peripheral prostaglandin E2 and EP subtypes in blood pressure regulation.
Prostaglandin E(2) (PGE(2)) is a major prostanoid with a wide variety of biological activities. PGE(2) can influence blood pressure (BP) both positively and negatively. In particular, centrally administered PGE(2) induces hypertension whereas systemic administration of PGE(2) produces a hypotensive effect. These physiologically opposing effects are generated by the existence of multiple EP receptors, namely EP(1-4), which are G protein-coupled receptors with distinct signaling properties. This review highlights the distinct roles of PGE(2) in BP regulation and the involvement of specific EP receptor subtypes.
Institute of Hypertension, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China. yangtianxin@mail.sysu.edu.cn
Tianxin
T
Yang
Yaomin
Y
Du
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology* / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000294:innervation; D018078:Receptors, Prostaglandin E / Q000502:physiology; D058307:Receptors, Prostaglandin E, EP2 Subtype / Q000187:drug effects / Q000502:physiology; D058308:Receptors, Prostaglandin E, EP3 Subtype / Q000187:drug effects / Q000502:physiology; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000187:drug effects / Q000502:physiology
D018078:Receptors, Prostaglandin E; D058307:Receptors, Prostaglandin E, EP2 Subtype; D058308:Receptors, Prostaglandin E, EP3 Subtype; D058309:Receptors, Prostaglandin E, EP4 Subtype; D015232:Dinoprostone