Is it time for a metagenomic basis of therapeutics?
The trillions of microbes associated with the human body are a key part of a comprehensive view of pharmacology. A mechanistic understanding of how the gut microbiota directly and indirectly affects drug metabolism is beginning to emerge.
Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA, USA.
Henry J
HJ
Haiser
Peter J
PJ
Turnbaugh
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D004358:Drug Therapy; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D054892:Metagenome; D056186:Metagenomics; D018977:Micronutrients / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018977:Micronutrients; D004364:Pharmaceutical Preparations