Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells.
The mechanisms whereby medulloblastoma stem cells coordinate tumor propagation are poorly understood. Using microarray analysis, Corno and colleagues draw parallels and distinctions between medulloblastoma stem cells from the Ptch(+/-) mouse and normal neural stem cells, identifying Ebf3 as a cancer stem cell-specific transcript critical for tumor growth.
Department of Pathology, The Pediatric Brain Tumor Foundation Institute, and The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA.
Matthew
M
Wortham
Hai
H
Yan
D000818:Animals; D002528:Cerebellar Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics*