Optic nerve head morphology and visual field function in patients with AIDS and without infectious retinitis.
OBJECTIVE
To evaluate morphology of the optic nerve head and visual field in AIDS patients without retinitis.


METHODS
One randomly selected eye from 246 patients with AIDS without retinitis was evaluated from prospective multicenter Longitudinal Studies of Ocular Complications of AIDS. Stereo fundus photographs of OHN and serial VF data over 5-years were analyzed. Main outcomes included vertical cup-to-disc ratio (CDR), mean deviation, and pattern standard deviation scores on VF testing.


RESULTS
The median CDR was 0.39 at enrollment and 0.40 at 5-year follow-up. An unadjusted linear regression model revealed a mean change in CDR of 0.004 after 5-years (P = 0.04). After adjustment for practice effect, there were no statistically significant changes in VF performance observed during the 5 years of follow-up.


CONCLUSIONS
We detected clinically minimal, but statistically significant changes in ONH morphology and no change in VF performance among eyes of patients with AIDS and without retinitis.
Department of Ophthalmology, University of California San Diego, Jacobs Retina Center at Shiley Eye Center, La Jolla, California 92037, USA. ikozak@eyecenter.ucsd.edu
Igor
I
Kozak
Alka
A
Ahuja
Sapna
S
Gangaputra
Mark L
ML
Van Natta
Jennifer E
JE
Thorne
William R
WR
Freeman
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D000328:Adult; D017726:Cytomegalovirus Retinitis / Q000473:pathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D058609:Visual Field Tests; D014794:Visual Fields