Detection of the rare HLA-B*40:97 allele in an unrelated Taiwanese bone marrow donor.
We detected a rare HLA-B locus allele, B*40:97, in a Taiwanese unrelated donor in our routine HLA SBT (sequence-based typing) exercise for a possible hematopoietic stem cell donation. In exons 2, 3 and 4, the sequence of B*40:97 is identical to the sequence of B*40:02:01 except one nucleotide at nucleotide position 760 (C->T) in exon 4. The nucleotide variation caused one amino acid alteration at residue 230 (L->F). B*40:97 was probably derived from a nucleotide substitution event where C was replaced by T at nucleotide 760 involving B*40:02:01. The HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 haplotype in association with B*40:97 may be deduced as A*26:01-B*40:97-C*03:03-DRB1*11:01-DQB1*03:03. Our recognition of B*40:97 in Taiwanese helps to fill the void of ethnic information for the allele B*40:97 reported to the IMGT/HLA Database.
Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry, Buddhist Tzu Chi General Hospital, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan.
K L
KL
Yang
S K
SK
Lee
R H
RH
Kao
C L
CL
Lin
P Y
PY
Lin
D000483:Alleles; D000596:Amino Acids / Q000235:genetics; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism*; D059947:HLA-B40 Antigen / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000235:genetics; D013624:Taiwan; D014019:Tissue Donors
D000596:Amino Acids; D059947:HLA-B40 Antigen; D009711:Nucleotides