[Intravascular large B-cell lymphoma with low signal intensity lesions on T2 weighted spinal magnetic resonance image that were suspected to be hemorrhages].
A 79-year-old female had a spinal lesion that was definitely diagnosed as intravascular large B-cell lymphoma on the basis of skin biopsy findings, and she was treated by rituximab-containing chemotherapy. The spinal lesion showed high and low signal intensities on T₂ weighted magnetic resonance imaging (MRI) scans, those low signal intensity lesions were suspected to be hemorrhages. The hemorrhages were thought to have been caused by interaction between atypical lymphoma cells and the endothelial cells of spinal blood vessels, by hemorrhagic infarction or by rupture of the capillary endothelium due to interaction between rituximab and lymphoma cells. Intravascular large B-cell lymphoma cases rarely show low signal intensity on spinal T₂ weighted MRI scans.
Department of Neurology, Nishibeppu National Hospital.
Tomoko
T
Ishikawa
Yuko
Y
Ogata
Junko
J
Tsuda
Katsumasa
K
Goto
Hiroshi
H
Kikuchi
D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D000069283:Rituximab; D012867:Skin / Q000098:blood supply / Q000473:pathology; D013116:Spinal Cord / Q000098:blood supply; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000209:etiology*; D019043:Vascular Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology
D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab