[A case of pulmonary embolism due to heparin-induced thrombocytopenia after the placement of hepatic arterial infusion catheter].
A 68-year-old woman developed acute pulmonary embolism after hepatic arterial infusion therapy for advanced hepatocellular carcinoma. Because the platelet count was significantly reduced, heparin-induced thrombocytopenia (HIT) due to heparin usage in hepatic arterial infusion therapy was clinically suspected. Subsequently, the patient tested positively for HIT antibodies, and a definitive diagnosis was obtained. Antithrombotic therapy with heparin was discontinued and treatment with argatroban was started. After the heparinized hydrophilic catheter was removed, the platelet count improved immediately. HIT should be considered when a decrease in platelet count and thrombosis are involved with the usage of heparin.
Department of Gastroenterology, Saiseikai Kumamoto Hospital. yoki1374@yahoo.co.jp
Yoki
Y
Furuta
Koichi
K
Kudoh
Shuji
S
Tada
Kazuaki
K
Sugihara
Kazuhiro
K
Izumi
Yoshihiro
Y
Kadono
Kentarou
K
Kamikawa
Hideto
H
Chikazawa
Haruo
H
Imamura
D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000188:drug therapy; D011655:Pulmonary Embolism / Q000209:etiology*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications*
D000925:Anticoagulants; D006493:Heparin