Fungal keratitis responsive to moxifloxacin monotherapy.
OBJECTIVE
To report 5 cases of culture-proven fungal keratitis that resolved with moxifloxacin monotherapy.


METHODS
Case reports and review of medical literature. Five patients with fungal keratitis were treated with topical moxifloxacin.


RESULTS
All 5 patients had resolution of their infection with topical moxifloxacin monotherapy.


CONCLUSIONS
Topical fluoroquinolone agents may have significant antifungal properties. However, the vast majority of fungal keratitis patients cannot be cured with fluoroquinolone monotherapy. An initial response of keratitis to topical fluoroquinolone therapy should not lead to the assumption that the infection is bacterial because the possibility of fungal infection cannot be ruled out on that basis.
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA. amatoba@bcm.edu
Alice Y
AY
Matoba
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000302:isolation & purification; D001230:Aspergillus / Q000302:isolation & purification; D001372:Aza Compounds / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D010143:Paecilomyces / Q000302:isolation & purification; D011804:Quinolines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin