Hemophagocytic syndrome secondary to adult-onset Still's disease but very similar to lymphoma.
Hemophagocytic syndrome (HPS) is a clinicopathologic entity characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. HPS may be primary, or secondary to malignancy, infections, auto-immune diseases and pharmacotherapy. In patients with adult-onset Still's disease (AOSD), HPS is a rare but life-threatening complication. Herein, we described a female patient with HPS secondary to AOSD. During the therapy, giant gastric ulcer similar to lymphoma developed after treatment with corticosteroid and nonsteroidal anti-inflammatory drugs.
Department of Dermatology and Rh.eumatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xin-Hua
XH
Zhang
Yong-Mei
YM
Han
Wen-Wen
WW
Wang
Hao
H
Cheng
Ke-Jian
KJ
Zhu
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001706:Biopsy; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008223:Lymphoma / Q000175:diagnosis*; D011237:Predictive Value of Tests; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013276:Stomach Ulcer / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors