Sensitive biological detection with a soluble and stable polymeric paramagnetic nanocluster.
We describe the design, synthesis, and biological characterization of manganese oxocluster-based "single molecule magnets (SMMs)". We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelle that features SMM.
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, Missouri 63108, USA.
Benjamin
B
Kim
Anne H
AH
Schmieder
Allen J
AJ
Stacy
Todd A
TA
Williams
Dipanjan
D
Pan
D000818:Animals; D004355:Drug Stability; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008345:Manganese / Q000737:chemistry*; D008823:Micelles; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D012680:Sensitivity and Specificity; D012995:Solubility
D008823:Micelles; D011108:Polymers; D008345:Manganese