The influence of bleeding on trigger changes for platelet transfusion in patients with chemotherapy-induced thrombocytopenia.
BACKGROUND
For patients with thrombocytopenia without bleeding risk factors, a platelet transfusion trigger of 10 × 10(9) /L is recommended. No studies have evaluated the clinicians' decision-making process leading to trigger changes.


METHODS
We report on the evaluation of trigger changes and the relation with bleeding. Eighty patients previously enrolled in the SPRINT trial represent the patient population for the current analysis.


RESULTS
Seventy-four patients had a starting trigger of 10 × 10(9) /L. Only a minority of patients treated with chemotherapy alone (3/12, 25%) and autologous transplant (6/15, 40%) had a change in their trigger in contrast to the majority of allogeneic transplant (37/47, 79%; p = 0.001 and p = 0.009, respectively, when compared to allogeneic transplant group). Bleeding was the main reason reported by clinicians for a trigger change, but the occurrence of significant bleeding (Grade 2-4) was similar in patients with or without a trigger change (51 and 54%, p = 1.00). Clinicians were influenced by the bleeding system: grade 1 mucocutaneous bleeding leading to a trigger change was overrepresented (71% of cases), as was grade 2 genitourinary bleeding not leading to a trigger change (57% of cases).


CONCLUSIONS
A universal trigger of 10 × 10(9) /L may not be maintained in a diverse population of patients with their respective bleeding risk factors. Because the trigger is changed often, it may not be as effective as previously believed.
Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Institute for Engineering in Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Benjamin
B
Rioux-Massé
Vincent
V
Laroche
Robert J
RJ
Bowman
Bruce R
BR
Lindgren
Claudia S
CS
Cohn
Shelley M
SM
Pulkrabek
Jeffrey
J
McCullough
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000150:complications* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000379:methods; D011379:Prognosis; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
D000970:Antineoplastic Agents