Sequential FDG PET and MRI findings in a case of human herpes virus 6 limbic encephalitis.
A 50-year-old woman developed a human herpes virus 6 limbic encephalitis characterized by memory loss and somnolence, 3 weeks after a cord blood-derived stem cell transplantation. Sequential scalp electroencephalogram failed to detect seizure activity. Cerebrospinal fluid polymerase chain reaction assay demonstrated human herpes virus 6 deoxyribonucleic acid (positive, 3.74 log). Acute phase FDG PET imaging showed bilateral intense FDG uptake in both hippocampi and amygdalae. After antiviral treatment (gancyclovir followed by foscarnet), neurologic symptoms disappear gradually. Late phase FDG PET imaging showed a regression in FDG uptake representing hippocampal hypometabolism because of hippocampal sclerosis.
Service de Biophysique et Médecine Nucléaire, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, and Université de Strasbourg/CNRS, UMR 7237, France.
Fabrice
F
Hubele
Karin
K
Bilger
Stéphane
S
Kremer
Alessio
A
Imperiale
Bruno
B
Lioure
Izzie Jacques
IJ
Namer
D005260:Female; D019788:Fluorodeoxyglucose F18; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D020363:Limbic Encephalitis / Q000000981:diagnostic imaging* / Q000821:virology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019349:Roseolovirus Infections / Q000000981:diagnostic imaging / Q000821:virology*
D019788:Fluorodeoxyglucose F18