Role of signal-to-cutoff ratios in hepatitis C virus antibody detection.
We reviewed results from 12,800 samples tested for hepatitis C virus (HCV) antibody detection in our laboratory by screening (Ortho chemiluminescence immunoassay [CIA]) and supplemental tests (Chiron recombinant immunoblot assay [RIBA]). We found that a signal-to-cutoff (S/Co) ratio of 10.3 was, in our setting, the most efficient cutoff point to improve the diagnostic algorithm of HCV infection.
Laboratorio Patologia Clinica, Ospedale S. Croce, A.O.R.M.N., Fano, Italy. marcomoretti18@libero.it
Marco
M
Moretti
Barbara
B
Pieretti
Annamaria
A
Masucci
Davide
D
Sisti
Marco
M
Rocchi
Ernesto
E
Delprete
D019411:Clinical Laboratory Techniques / Q000379:methods / Q000592:standards*; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000175:diagnosis*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D007118:Immunoassay / Q000379:methods / Q000592:standards
D018937:Hepatitis C Antibodies