Nickel-catalyzed reductive coupling of aryl halides with secondary alkyl bromides and allylic acetate.
A room-temperature Ni-catalyzed reductive method for the coupling of aryl bromides with secondary alkyl bromides has been developed, providing C(sp(2))-C(sp(3)) products in good to excellent yields. Slight modification of this protocol allows efficient coupling of activated aryl chlorides with cyclohexyl bromide and aryl bromides with allylic acetate.
Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
Shulin
S
Wang
Qun
Q
Qian
Hegui
H
Gong
D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
D000085:Acetates; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D009942:Organometallic Compounds; D009532:Nickel