Leishmania virulence factors: focus on the metalloprotease GP63.
Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.
Department of Medicine, The Research Institute of the McGill University Health Centre, Faculty of Medicine, McGill University, Montréal, Québec, Canada. martin.olivier@mcgill.ca
Martin
M
Olivier
Vanessa Diniz
VD
Atayde
Amandine
A
Isnard
Kasra
K
Hassani
Marina Tiemi
MT
Shio
D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D007891:Leishmania / Q000201:enzymology / Q000472:pathogenicity*; D007896:Leishmaniasis / Q000469:parasitology*; D008666:Metalloendopeptidases / Q000378:metabolism*; D011576:Psychodidae; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
D037521:Virulence Factors; D008666:Metalloendopeptidases; C055146:glycoprotein gp63, Leishmania