Sleep spindles predict neural and behavioral changes in motor sequence consolidation.
The purpose of this study was to investigate the predictive function of sleep spindles in motor sequence consolidation. BOLD responses were acquired in 10 young healthy subjects who were trained on an explicitly known 5-item sequence using their left nondominant hand, scanned at 9:00 pm while performing that same task and then were retested and scanned 12 h later after a night of sleep during which polysomnographic measures were recorded. An automatic algorithm was used to detect sleep spindles and to quantify their characteristics (i.e., density, amplitude, and duration). Analyses revealed significant positive correlations between gains in performance and the amplitude of spindles. Moreover, significant increases in BOLD signal were observed in several motor-related areas, most of which were localized in the right hemisphere, particularly in the right cortico-striatal system. Such increases in BOLD signal also correlated positively with the amplitude of spindles at several derivations. Taken together, our results show that sleep spindles predict neural and behavioral changes in overnight motor sequence consolidation.
Functional Neuroimaging Unit, Centre de recherche de l'institut gériatrique de l'université de Montréal, Québec, Canada; Center of Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada; Centre de recherche en neuropsychologie et en cognition, Department of Psychology, University of Montreal, Montreal, Québec, Canada.
Marc
M
Barakat
Julie
J
Carrier
Karen
K
Debas
Ovidiu
O
Lungu
Stuart
S
Fogel
Gilles
G
Vandewalle
Richard D
RD
Hoge
Pierre
P
Bellec
Avi
A
Karni
Leslie G
LG
Ungerleider
Habib
H
Benali
Julien
J
Doyon
D000328:Adult; D000465:Algorithms; D002540:Cerebral Cortex / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D017072:Neostriatum / Q000502:physiology; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D011597:Psychomotor Performance / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D055815:Young Adult
D010100:Oxygen