Palladium-catalyzed alkenylation and alkynylation of ortho-C(sp2)-H bonds of benzylamine picolinamides.
An efficient functionalization of ortho-C(sp(2))-H bonds of picolinamide (PA)-protected benzylamine substrates with a range of vinyl iodides as well as acetylenic bromide is reported. ortho-Phenyl benzoic acid (oPBA) acts as an effective promoter in this reaction system. This method provides a practical strategy to access highly functionalized benzylamine compounds for organic synthesis.
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Yingsheng
Y
Zhao
Gang
G
He
William A
WA
Nack
Gong
G
Chen