The dysplastic nevus: from historical perspective to management in the modern era: part II. Molecular aspects and clinical management.
The dysplastic nevus is a discreet histologic entity that exhibits some clinical and histologic features overlapping with common nevi and melanoma. These overlapping features present a therapeutic challenge, and with a lack of accepted guidelines, the management of dysplastic nevi remains a controversial subject. Although some differences between dysplastic and common nevi can be detected at the molecular level, there are currently no established markers to predict biologic behavior. In part II of this continuing medical education article, we will review the molecular aspects of dysplastic nevi and their therapeutic implications. Our goal is to provide the clinician with an up-to-date understanding of this entity to facilitate clinical management of patients with nevi that have histologic dysplasia.
Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Keith
K
Duffy
Douglas
D
Grossman
D017209:Apoptosis; D049109:Cell Proliferation; D004416:Dysplastic Nevus Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D016147:Genes, Tumor Suppressor; D006801:Humans; D053842:Microsatellite Instability; D009154:Mutation