Non-islet cell tumour hypoglycaemia.
Non-islet cell tumour hypoglycaemia is a rare paraneoplastic phenomenon where there is spontaneous hypoglycaemia due to secretion of insulin-like growth factor-2 (IGF-2) from large mesenchymal or epithelial tumours. A 67-year-old man presented to the accident and emergency department with a 6-week history of confusion and collapse. Investigations confirmed that he was having recurrent hypoglycaemic attacks. He had been diagnosed with a pelvic solitary fibrous tumour 1 year previously. Further tests demonstrated a high circulating level of IGF-2, which was being secreted by the tumour, confirming a diagnosis of non-islet cell tumour hypoglycaemia. The episodes of hypoglycaemia have resolved following treatment with glucocorticoids. He is currently awaiting radiotherapy.
Department of Diabetes and Endocrinology, West Suffolk Hospitals, Bury St. Edmunds, UK. leenadamu@gmail.com
Leena
L
Krishnan
John
J
Clark
D000368:Aged; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010386:Pelvic Neoplasms / Q000150:complications* / Q000378:metabolism; D054364:Solitary Fibrous Tumors / Q000150:complications* / Q000378:metabolism
D007335:Insulin-Like Growth Factor II