Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs.
A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A-C (11-13), together with 10 known compounds (1-10). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1-5 and 7 were significant inhibitors of xanthine oxidase, with IC(50) values ranging from 7.8 to 36.3 μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.
National Institute of Medicinal Materials, Hanoi, Viet Nam.
Tran Minh
TM
Ngoc
Nguyen Minh
NM
Khoi
Do Thi
do T
Ha
Nguyen Xuan
NX
Nhiem
Bui Huu
BH
Tai
Dao Van
DV
Don
Hoang Van
HV
Luong
Doan Cao
DC
Son
KiHwan
K
Bae
D032904:Cinnamomum aromaticum / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D014969:Xanthine Oxidase