Are the severe injuries of cutaneous leishmaniasis caused by an exacerbated Th1 response?
American tegumentary leishmaniasis (ATL) is a disease whose clinical features are strongly related to the type of immune response it induces. Herein we report an atypical presentation of cutaneous leishmaniasis in a woman with a severe and extensive sore located in her leg, and we describe the differences between the usual local immune response in ATL and the local immune response in this patient. We observed an intense inflammatory response characterized by Th1 cells and cytokines with conspicuous expression of Toll-like receptor 3 (TLR-3). Few parasites were present, but there was an extensive tissue damage. We also discuss the immunological factors that could be related to the atypical presentation.
Department of Infectious Diseases, University of São Paulo, Medical School, São Paulo, Brazil. ac_nicodemo@uol.com.br
Antonio C
AC
Nicodemo
V S
VS
Amato
A M
AM
Miranda
L M F
LM
Floeter-Winter
R A
RA
Zampieri
E R
ER
Fernades
M I S
MI
Duarte
D000328:Adult; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D007866:Leg / Q000473:pathology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000473:pathology*; D012867:Skin / Q000276:immunology* / Q000473:pathology*; D018417:Th1 Cells / Q000276:immunology*; D051196:Toll-Like Receptor 3 / Q000096:biosynthesis
D016207:Cytokines; D051196:Toll-Like Receptor 3