Levels of non enzymatic antioxidants in Down syndrome.
OBJECTIVE
To confirm the clinical diagnosis of Down syndrome by chromosomal analysis and to explore the oxidative stress in children with Down syndrome by estimating the levels of non enzymatic antioxidants like reduced glutathione(GSH) and total antioxidants status (TAS).


METHODS
The study included 31 clinically diagnosed children with Down syndrome with equal number of age and sex matched controls. Trisomy 21 was confirmed by conventional lymphocyte cell culture. Erythrocytic reduced glutathione (GSH) and plasma total antioxidant status (TAS) were measured sphectrophotometrically.


RESULTS
The levels of erythrocytic reduced glutathione (GSH) and plasma total antioxidant status (TAS) were significantly reduced in children with Down syndrome.


CONCLUSIONS
Children with Down syndrome have elevated levels of oxidative stress . Hence antioxidant therapy can be beneficial among them.
Cytogenetics Division, Department of Anatomy, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
S Mehar
SM
Sulthana
S Nandha
SN
Kumar
M G
MG
Sridhar
B Vishnu
BV
Bhat
K Ramachandra
KR
Rao
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018384:Oxidative Stress
D000975:Antioxidants; D015415:Biomarkers; D005978:Glutathione