Ligand binding by PDZ domains.
The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Celestine N
CN
Chi
Anders
A
Bach
Kristian
K
Strømgaard
Stefano
S
Gianni
Per
P
Jemth
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009422:Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D054731:PDZ Domains; D057786:Peptidomimetics / Q000494:pharmacology / Q000627:therapeutic use; D011485:Protein Binding; D017433:Protein Structure, Secondary; D021381:Protein Transport; D015398:Signal Transduction
D008024:Ligands; D009419:Nerve Tissue Proteins; D057786:Peptidomimetics