Conditioned food aversion reconsolidation in snails is impaired by translation inhibitors but not by transcription inhibitors.
Memory is destabilized during retrieval-induced reconsolidation and can therefore be disrupted or modified. In the present study, we examined the role of translation and transcription processes in long-term food aversion memory reconsolidation in the snail Helix lucorum. The administration of the protein synthesis inhibitor anisomycin followed by a reminding procedure (presentation of the conditioned stimulus) led to the development of amnesia that persist for 2 weeks or longer. Administration of the mRNA synthesis inhibitors actinomycin D, α-amanitin, or DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidasole) followed by a reminding procedure did not affect memory retrieval. Our present findings indicate that proteins synthesized from preexisting mRNA that is transcribed during learning and stored in a silent state may be involved in the mechanisms of conditioned food aversion reconsolidation.
Laboratory of Functional Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Mokhovaya str. 11/4, 125009 Moscow, Russian Federation.
Svetlana
S
Solntseva
Vladimir
V
Nikitin
D053959:Alpha-Amanitin / Q000494:pharmacology; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D004004:Dichlororibofuranosylbenzimidazole / Q000494:pharmacology; D005502:Food; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D012908:Snails / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects*
D053959:Alpha-Amanitin; D019384:Nucleic Acid Synthesis Inhibitors; D011500:Protein Synthesis Inhibitors; D012333:RNA, Messenger; D003609:Dactinomycin; D004004:Dichlororibofuranosylbenzimidazole; D000841:Anisomycin