Membrane biology: fission behind BARs.
Membrane bending is accomplished in part by amphipathic helix insertion into the bilayer and the assembly of BAR domain scaffolds preparing the membrane for fission. Two recent studies highlight the roles of amphipathic helices and BAR scaffolds in membrane fission and establish the structural basis of membrane bending by the N-BAR protein endophilin.
Leibniz Institut für Molekulare Pharmakologie, 13125 Berlin, Germany. yasu@igm.hokudai.ac.jp
Volker
V
Haucke
D000217:Acyltransferases / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*
D008565:Membrane Proteins; D000217:Acyltransferases; C018764:2-acylglycerophosphate acyltransferase