Outcomes of repeat endothelial keratoplasty in patients with failed Descemet stripping endothelial keratoplasty.
OBJECTIVE
To report the outcomes of repeat endothelial keratoplasty (EK) in patients with failed Descemet stripping endothelial keratoplasty (DSEK).


METHODS
The clinical records of patients with failed DSEK who underwent repeat EK surgery at a single institution were reviewed.


RESULTS
A total of 20 eyes of 20 patients (8 men and 12 women) were included. The mean age at initial DSEK surgery was 69.9 ± 11.9 years (range, 41-83 years). The causes of DSEK failure included progressive endothelial failure (8 eyes; 40%), primary graft failure (8 eyes; 40%), and endothelial rejection (4 eyes; 20%). The mean duration from primary DSEK to repeat EK was 13.1 ± 10.3 months (range, 2-33 months). Removal of the failed DSEK donor disc was performed in all eyes. Mean preoperative corrected distance visual acuity (logMAR) before repeat EK surgery was 1.76, and this improved to 0.5 (P < 0.001) at the final follow-up at 27 months. Three eyes had limited corrected distance visual acuity secondary to ocular comorbidities (age-related macular degeneration and advanced glaucomatous optic neuropathy).


CONCLUSIONS
Repeat EK in patients with DSEK failure is an effective treatment modality. This is the preferred management option compared with penetrating keratoplasty because the advantages of EK surgery are maintained with repeat EK surgery.
Department of Ophthalmology, Toronto Western Hospital, University of Toronto, Ontario, Canada. peterkim76@gmail.com
Peter
P
Kim
Sonia N
SN
Yeung
Alejandro
A
Lichtinger
Maoz D
MD
Amiran
Shobha V
SV
Shanmugam
Alfonso
A
Iovieno
Allan R
AR
Slomovic
David S
DS
Rootman
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055954:Corneal Endothelial Cell Loss / Q000209:etiology / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty; D004728:Endothelium, Corneal / Q000637:transplantation*; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology