Restoring stem cell function in aged tissues by direct reprogramming?
Adult stem cells are responsible for the cellular turnover of many organs, and an impairment in their function leads to aging and disease. In efforts to reverse the process of tissue stem cell aging, we speculate on the promise and challenges of in vivo direct reprogramming strategies.
Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Münster, Germany.
Natalia
N
Tapia
Department of Stem Cell Biology, School of Medicine, SMART Institute of Advanced Biomedical Science, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Dong Wook
DW
Han
Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstraße 20, 48149 Münster, Germany; University of Münster, Medical Faculty, Domagkstrasse 3, 48149 Münster, Germany. Electronic address: office@mpi-muenster.mpg.de.
Hans R
HR
Schöler
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology* / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*