Atypical tumour-like involvement of the colon in secondary systemic amyloidosis which vanished after 1 month of observation.
Amyloidosis occurs as a result of the extracellular deposition of protein fibrils in organs and tissues, thus causing mild to severe pathophysiological changes. The gastrointestinal tract is a common site of amyloid deposition. While intestinal amyloidosis frequently results in polypoid lesions, ulcerations, nodules and petechial mucosal haemorrhage, tumour-like lesions are rarely developed and infrequently diagnosed before the resection because of the difficulty in differentiating them from colon cancer. The authors herein reported a case of intestinal amyloid A amyloidosis with a complication of a tumour-like lesion endoscopically resembling a malignant lesion, which was completely diminished after 1 month of observation with bowel rest. Such conservative treatment is a feasible option to cure intestinal tumour-like lesions in patients with intestinal amyloidosis when no neoplastic change is histologically detected, possibly decreasing the need for surgery of the fragile mucosa.
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
Katuyoshi
K
Ando
Mikihiro
M
Fujiya
Takahiro
T
Ito
Ryuji
R
Sugiyama
Toshie
T
Nata
Yoshiki
Y
Nomura
Nobuhiro
N
Ueno
Shin
S
Kashima
Chisato
C
Ishikawa
Yuhiei
Y
Inaba
Kentaro
K
Moriichi
Kotaro
K
Okamoto
Katsuya
K
Ikuta
Yusuke
Y
Mizukami
Yoshihiko
Y
Tokusashi
Naoyuki
N
Miyokawa
Jiro
J
Watari
Yutaka
Y
Kohgo
D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy; D003108:Colonic Diseases / Q000175:diagnosis* / Q000628:therapy; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D010289:Parenteral Nutrition, Total