Nitric oxide inhibitory activity of monogalactosylmonoacylglycerols from a freshwater microalgae Chlorella sorokiniana.
Chemical investigation of the freshwater microalgae Chlorella sorokiniana led to the isolation of a new monogalactosylmonoacylglycerol, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (1) together with a known glycolipid (2S)-1-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O-β-D-galactopyranosylglycerol (2). Both monogalactosylmonoacylglycerols showed dose-dependent nitric oxide (NO) inhibitory activity against lipopolysaccharide-induced NO production in RAW264.7 macrophage cells suggesting their possible use as anti-inflammatory agents.
Institute for Marine Biosciences, National Research Council, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, Canada. arjun.banskota@nrc-cnrc.gc.ca
Arjun H
AH
Banskota
Roumiana
R
Stefanova
Pamela
P
Gallant
Jane A
JA
Osborne
Ronald
R
Melanson
Stephen J B
SJ
O'Leary
D002708:Chlorella / Q000737:chemistry*; D005618:Fresh Water; D005990:Glycerol / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*
D009569:Nitric Oxide; D005990:Glycerol