Adaptive trials in clinical research: scientific and ethical issues to consider.
University Medical Center Utrecht, Utrecht, The Netherlands. r.vandergraaf@umcutrecht.nl
Rieke
R
van der Graaf
Kit C B
KC
Roes
Johannes J M
JJ
van Delden
D032984:Ethics, Research; D006801:Humans; D007258:Informed Consent; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000941:ethics*; D015203:Reproducibility of Results; D012107:Research Design; D012945:Social Values