Tau Phosphorylation by GSK3 in Different Conditions.
Almost a 20% of the residues of tau protein are phosphorylatable amino acids: serine, threonine, and tyrosine. In this paper we comment on the consequences for tau of being a phosphoprotein. We will focus on serine/threonine phosphorylation. It will be discussed that, depending on the modified residue in tau molecule, phosphorylation could be protective, in processes like hibernation, or toxic like in development of those diseases known as tauopathies, which are characterized by an hyperphosphorylation and aggregation of tau.
Centro de Biologia Molecular "Severo Ochoa" (CSIC-UAM), Nicolás Cabrera 1, Campus Cantoblanco UAM, 28049 Madrid, Spain.
Jesús
J
Avila
Gonzalo
G
León-Espinosa
Esther
E
García
Vega
V
García-Escudero
Félix
F
Hernández
Javier
J
Defelipe