[Comparative evaluation of reamberin and mafusol on acute toxic liver damage models].
Comparative evaluation of the infusion of reamberin and mafusol has been carried out on the model of toxic liver damage caused by ammonium chloride. Reamberin contributed to more rapid normalization of indices due to an increase in the substrate reserve for energy metabolism. In a group of animals with alcohol intoxication, only the treatment with Reamberin allowed the system of antioxidant protection (reduced glutathione, thiol groups) and functional activity of the liver to be to normalized by the end of experiments on a level of the control group (intact animals).
A Iu
AIu
Petrov
V A
VA
Zaplutanov
D S
DS
Sukhanov
M G
MG
Romantsov
A L
AL
Kovalenko
D000255:Adenosine Triphosphate / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000150:complications; D000643:Ammonium Chloride / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D019610:Cytoprotection; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects; D005561:Formates / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008536:Meglumine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage; D013386:Succinates / Q000627:therapeutic use*
D000975:Antioxidants; D005561:Formates; C549374:Reamberin; D013386:Succinates; D000643:Ammonium Chloride; C030544:formic acid; D000431:Ethanol; D012965:Sodium Chloride; D008536:Meglumine; D000255:Adenosine Triphosphate; D005978:Glutathione