Restoration of a peri-implant defect by platelet-rich fibrin.
OBJECTIVE
The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo.


METHODS
Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.0 × 5.0 mm (width × length) were prepared after drilling to host the dental implant in the tibia. Subsequently, the 2 dental implants were installed (diameter, 3.0 mm and length, 8.0 mm). In the experimental group, PRF was applied into the bony defect. In the control group, the peri-implant defect was left unfilled. The animals were humanely killed 8 weeks after implantation and histomorphometric analysis was done.


RESULTS
In the histomorphometric analysis, mean new bone formation was 29.30% ± 7.50% in the experimental group and 11.06% ± 8.94% in the control group (P = .020). Mean bone-to-implant contact was 39.43% ± 7.39% in the experimental group and 17.11% ± 8.12% in the control group (P = .006).


CONCLUSIONS
In the animal model, peri-implant defect sized 3.0 × 5.0 mm (width × length) was successfully repaired by the application of PRF alone.
Resident, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Republic of Korea.
Jong-Won
JW
Lee
Seong-Gon
SG
Kim
Jwa-Young
JY
Kim
Yong-Chan
YC
Lee
Je-Yong
JY
Choi
Rosca
R
Dragos
Horatiu
H
Rotaru
D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000601:surgery*; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001861:Bone Regeneration; D015921:Dental Implants; D005337:Fibrin / Q000627:therapeutic use*; D006133:Growth Substances / Q000627:therapeutic use; D023421:Models, Animal; D011817:Rabbits; D013977:Tibia / Q000601:surgery
D015921:Dental Implants; D006133:Growth Substances; D005337:Fibrin