IL-23 receptor gene rs7517847 and rs1004819 SNPs in ulcerative colitis.
BACKGROUND
Crohn's disease (CD) and ulcerative colitis (UC) are two major clinical presentations of inflammatory bowel disease (IBD). Many novel candidate genes have been found to be associated with increased risk for IBD. Recently IL-23 receptor gene is identified as an IBD associated gene in genome-wide studies.


OBJECTIVE
To ascertain whether rs7517847 and rs1004819 SNPs in the IL-23 receptor gene are associated with UC in our population in Kerman, south east of Iran.


METHODS
A total of 85 patients with UC and 100 healthy controls enrolled in our study. Endoscopic procedure was performed for all patients to determine their disease severity. IL-23 receptor genotyping at positions rs7517847 and rs1004819 was done by PCR-RFLP technique.


RESULTS
The results of this study showed no association between the studied polymorphisms in the IL-23 receptor gene and UC in our population. However, we found a significant association between rs7517847 gene polymorphism in IL-23 receptor and two important clinical variables including blood in stool and bowel movements in UC patients.


CONCLUSIONS
The rs7517847 gene polymorphism in IL-23R may be related to the presence of blood in stool and bowel movements in patients with UC. Further functional analysis with other known IL-23 receptor genotypes and/or other candidate genes is necessary to confirm any genetic association with UC in our population.
Physiology Research Centre, Kerman University of Medical Sciences, Kerman, Iran, e-mail: mozhganmohammadi69@yahoo.co.uk.
Mohammad Mahdi
MM
Hayatbakhsh
Mohammad Javad
MJ
Zahedi
Mohsen
M
Shafiepour
Amin Reza
AR
Nikpoor
Mojgan
M
Mohammadi
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003093:Colitis, Ulcerative / Q000235:genetics*; D004252:DNA Mutational Analysis; D004724:Endoscopy; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*; D055815:Young Adult
C515500:IL23R protein, human; D018123:Receptors, Interleukin