Renal functional reserve in children with apparently normal congenital solitary functioning kidney.
OBJECTIVE
The aim of the study was to investigate renal functional reserve (RFR) and to assess its relationship with serum cystatin C and blood pressure in children with apparently normal congenital solitary functioning kidney (SFK).


METHODS
RFR was obtained from the difference of endogenous creatinine clearance (CrCs) before and after a meat-free oral protein load (OPL) in the patients who were pre-treated with cimetidine. Serum cystatin C and urinary protein excretion were determined before and after OPL.


RESULTS
Among 22 patients (13 boys), aged 9.5 ± 4.3 years, 72.7% had increased serum cystatin C, and 54.5% had decreased RFR. Following OPL, CrCs and urine creatinine increased, while serum creatinine and cystatin C remained unchanged. The multiple regression analysis demonstrated that cystatin C could predict more than 90% of RFR variability.


CONCLUSIONS
Half of the patients with apparently normal SFK had decreased RFR. Serum cystatin C is one of the best predictors of RFR.
Medical Faculty, University of Belgrade, Belgrade, Serbia. amirapecoantic@yahoo.com
Amira
A
Peco-Antić
Dušan
D
Paripović
Jelena
J
Kotur-Stevuljević
Aleksandra
A
Stefanović
Gordana
G
Sćekić
Gordana
G
Miloševski-Lomić
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology*; D007674:Kidney Diseases / Q000097:blood / Q000151:congenital* / Q000503:physiopathology; D008297:Male; D021782:Multicystic Dysplastic Kidney / Q000097:blood / Q000503:physiopathology; D015999:Multivariate Analysis; D009929:Organ Size; D012044:Regression Analysis
D055316:Cystatin C