A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy.
Patients with acute myeloid leukemia (AML) receiving induction chemotherapy (IC) were enrolled in a supervised exercise intervention to determine safety, feasibility, and efficacy. Physical fitness measures, quality of life (QOL) and fatigue were assessed using standardized measures at baseline, post-induction, and post first consolidation. Retention was excellent, the intervention was safe, and efficacy estimates suggested benefits in physical fitness and QOL outcomes. Exercise is a safe, promising intervention for improving fitness and QOL in this patient population. These results provide a foundation for a randomized trial to better understand the impact of exercise during IC on clinically important outcomes.
Department of Medicine, University Health Network, Toronto, ON, Canada. shabbir.alibhai@uhn.on.ca
Shabbir M H
SM
Alibhai
Sara
S
O'Neill
Karla
K
Fisher-Schlombs
Henriette
H
Breunis
Joseph M
JM
Brandwein
Narhari
N
Timilshina
George A
GA
Tomlinson
Heidi D
HD
Klepin
S Nicole
SN
Culos-Reed
D000328:Adult; D000368:Aged; D015444:Exercise; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007297:Inpatients; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome