No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.
BACKGROUND
A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.


RESULTS
We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.


CONCLUSIONS
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. sawai@m.u-tokyo.ac.jp
Hiromi
H
Sawai
Nao
N
Nishida
Hamdi
H
Mbarek
Koichi
K
Matsuda
Yoriko
Y
Mawatari
Megumi
M
Yamaoka
Shuhei
S
Hige
Jong-Hon
JH
Kang
Koichi
K
Abe
Satoshi
S
Mochida
Masaaki
M
Watanabe
Masayuki
M
Kurosaki
Yasuhiro
Y
Asahina
Namiki
N
Izumi
Masao
M
Honda
Shuichi
S
Kaneko
Eiji
E
Tanaka
Kentaro
K
Matsuura
Yoshito
Y
Itoh
Eiji
E
Mita
Masaaki
M
Korenaga
Keisuke
K
Hino
Yoshikazu
Y
Murawaki
Yoichi
Y
Hiasa
Tatsuya
T
Ide
Kiyoaki
K
Ito
Masaya
M
Sugiyama
Sang Hoon
SH
Ahn
Kwang-Hyub
KH
Han
Jun Yong
JY
Park
Man-Fung
MF
Yuen
Yusuke
Y
Nakamura
Yasuhito
Y
Tanaka
Masashi
M
Mizokami
Katsushi
K
Tokunaga
D001208:Asia; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000821:virology*; D002681:China; D015331:Cohort Studies; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000821:virology*; D020641:Polymorphism, Single Nucleotide