Photoinduced DNA cleavage by anthracene based hydroxamic acids.
Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (≥350nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure.
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Nilanjana
N
Chowdhury
Swagata
S
Dasgupta
N D
ND
Pradeep Singh
D000873:Anthracenes / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects / Q000528:radiation effects*; D006877:Hydroxamic Acids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D013329:Structure-Activity Relationship
D000873:Anthracenes; D006877:Hydroxamic Acids; C034020:anthracene