Cytotoxic constituents from the fungus Daldinia concentrica (Xylariaceae).
Phytochemical study on the methanol extract of the fruit bodies of Vietnamese fungus Daldinia concentrica has led to the isolation and structural elucidation of three cytotoxic constituents, 6,8-dihydroxy-3-methyl-3,4-dihydroisocoumarin (1), (22R)-hydroxylanosta-7,9(11),24-trien-3-one (2) and ergosterol (3). Their structures were elucidated by 2D-NMR and FT-ICR-MS. All the three compounds showed moderate cytotoxicity against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma). In addition, the isocoumarin (1) inhibited the growth of Staphylococcus aureus with the IC50 value of 87.81 µg mL(-1).
Faculty of Chemistry, Hanoi University of Education, 136 Xuan Thuy Road, Cau Giay, Hanoi, Vietnam. quangdn@hnue.edu.vn
Dang Ngoc
DN
Quang
Duong Minh
DM
Lam
Nguyen Thi Hong
NT
Hanh
Do Duc
do D
Que
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013211:Staphylococcus aureus; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D013098:Xylariales / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D049934:Isocoumarins; D014315:Triterpenes