Correlation between ischemia-modified albumin and lipid levels in patients             with acute cerebrovascular disease.
Acute cerebrovascular disease (ACVD) is associated with high morbidity and             mortality rates, however, molecular markers to aid in its early detection are             lacking. In this study, we examined the correlation between serum ischemia-modified             albumin (IMA), a marker used to identify ischemic events in the heart, and blood             lipids in patients with ACVD. Serum IMA levels were determined by enzyme-linked             immuno-sorbent assay, and total cholesterol (TC), low-density lipoprotein (LDL),             high‑density lipoprotein cholesterol (HDL) and triglyceride (TG) levels were determined             biochemically in 62 patients with cerebral infarction (CI), 40 patients with intracerebral             hemorrhage (ICH), 18 patients with subarachnoid hemorrhage (SAH) and 100 healthy             individuals (controls). Serum IMA levels were significantly higher in each of             the ACVD groups compared to the control group (CI, 80.81±11.97 U/ml; ICH, 80.25±10.91 U/ml;             SAH, 74.43±11.39 U/ml and control, 41.08±5.10 U/ml; P<0.05). Additionally,             serum TC, LDL and TG levels significantly increased, while serum HDL significantly             decreased in the ACVD groups compared to the control group (P<0.05). A positive             correlation was found between serum IMA levels and serum TC, LDL and TG levels             in the ACVD patients, while serum IMA levels were negatively correlated with serum             HDL levels (P<0.05). Thus, serum IMA increased following an ACVD event and             was closely correlated with changes in the blood lipid levels. These factors,             when combined, may allow the development of molecular markers for an earlier diagnosis             of ACVD.
Department of Neurology, The First Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning 121001, PR China. jinzhouhk@126.com
Kun
K
Han
Ning
N
Jia
Li
L
Yang
Lian-Qiu
LQ
Min
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000175:diagnosis; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D014280:Triglycerides; C561522:ischemia-modified albumin; D002784:Cholesterol; D000075462:Serum Albumin, Human