Inverse relationship between central obesity and osteoporosis in osteoporotic drug naive elderly females: The Tianliao Old People (TOP) Study.
To examine the relationship between central obesity and osteoporosis in elderly females in a rural community, a total of 368 ambulatory elderly women were recruited by random sampling during July 2009. Structured questionnaires were completed to survey possible osteoporosis-related risk factors. Subjects were dichotomized into either noncentral obese (waist circumference [WC]<80cm) or central obese subgroups (WC≥80cm) for further analysis. Bone mineral densities were scanned by dual-energy X-ray absorptiometry installed in a mobile bus. Thoracolumbar spine X-ray examination was interpreted by the same radiologist. Of the 365 subjects with completed data, 275 (75.3%) aged women were classified as having osteoporosis based on diagnostic Model III. Compared with the nonosteoporosis subjects, the subjects with osteoporosis had relatively higher mean age, lower body mass index, and a lower percentage of central obesity. Using the binary logistic regression method, central obesity was negatively associated with osteoporosis in all 3 models (odds ratios in the 3 models were 0.348, 95% confidence interval [CI]: 0.130-0.927; 0.444, 95% CI: 0.218-0.905; and 0.415, 95% CI: 0.184-0.936, respectively; p<0.05). Our study suggests that the paradox between central obesity and osteoporosis in elderly women should be of concern and warrants further study.
Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
Chin-Sung
CS
Chang
Yin-Fan
YF
Chang
Mei-Wen
MW
Wang
Chuan-Yu
CY
Chen
Yu-Jang
YJ
Chao
Hsuan-Jui
HJ
Chang
Po-Hsiu
PH
Kuo
Yi-Ching
YC
Yang
Chih-Hsing
CH
Wu
D000368:Aged; D015519:Bone Density; D015897:Comorbidity; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D056128:Obesity, Abdominal / Q000453:epidemiology*; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D012424:Rural Population; D013624:Taiwan; D055105:Waist Circumference