Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.
Rodent models and molecular tools, mainly omics and RNA interference, have been rigorously used to decode the intangible etiology and pathogenesis of Parkinson's disease (PD). Although convention of contemporary molecular techniques and multiple rodent models paved imperative leads in deciphering the role of putative causative factors and sequential events leading to PD, complete and clear-cut mechanisms of pathogenesis are still hard to pin down. The current article reviews the implications and pros and cons of rodent models and molecular tools in understanding the molecular and cellular bases of PD pathogenesis based on the existing literature. Probable rationales for short of comprehensive leads and future possibilities in spite of the extensive applications of molecular tools and rodent models have also been discussed.
CSIR-Indian Institute of Toxicology Research, Lucknow-226 001, Uttar Pradesh, India.
Sharawan
S
Yadav
Anubhuti
A
Dixit
Sonal
S
Agrawal
Ashish
A
Singh
Garima
G
Srivastava
Anand Kumar
AK
Singh
Pramod Kumar
PK
Srivastava
Om
O
Prakash
Mahendra Pratap
MP
Singh
D000818:Animals; D004195:Disease Models, Animal; D023281:Genomics; D008967:Molecular Biology / Q000379:methods*; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D034622:RNA Interference; D012377:Rodentia