βig-h3 supports gastric cancer cell adhesion, migration and proliferation             in peritoneal carcinomatosis.
βig-h3 is an extracellular matrix protein and its expression is highly induced             by transforming growth factor (TGF-β). It has also been suggested to play an important             role in the growth and invasion of colon and pancreatic cancers. In the present             study, we demonstrated that βig-h3 is expressed in mesothelial cells, especially             in patients with advanced gastric cancer. The positive rate of βig-h3 was significantly             higher in cases with a more invasive and advanced serous-type, with visible peritoneal             metastasis, and in peritoneal lavage cytological examination (PLC) (+) and peritoneal             lavage fluid CEA mRNA(+) subgroups (p<0.05). Our study also showed that the             expression of βig-h3 gradually increased with increasing TGF-β1 concentrations             in vitro in a time-dependant manner. In addition, βig-h3 also induced human gastric             carcinoma cell line (SGC-7901) cell adhesion in a dose-dependent manner and significantly             increased cell migration and proliferation. The results suggest that βig-h3 expression             in peritoneal mesothelial cells in gastric cancer patients is a marker of the             biological behavior of gastric cancer and plays an important role in the process             of peritoneal carcinomatosis.
Department of General Surgery, Fourth Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
Zhen
Z
Li
Zhifeng
Z
Miao
Guanghua
G
Jin
Xiaoxia
X
Li
Hongwu
H
Li
Zhidong
Z
Lv
Hui-Mian
HM
Xu
D002272:Carcinoembryonic Antigen / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D000099222:betaIG-H3 Protein
D002272:Carcinoembryonic Antigen; D016326:Extracellular Matrix Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein