[Primitive neuroectodermal tumor of the testis. Molecular analysis and discussion of genesis].
We describe a case of a testicular primitive neuroectodermal tumor (PNET) with intratubular germ cell neoplasia of the adjacent testicular parenchyma. The occurrence of testicular PNET is rare because malignant transformation of testicular germ cell tumors into somatic malignancy is uncommon. Based on morphological, immunohistochemical and molecular pathological findings these tumors resemble central PNETs as they otherwise typically occur in children without rearrangement of the Ewing sarcoma breakpoint region (EWSR) gene on chromosome 22. This case also showed no evidence for a translocation.
Institut für Klinische Pathologie, Universitätsspital Zürich, Schmelzbergstr. 12, 8091, Zürich, Schweiz. simone.brandt@usz.ch
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S
Brandt
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Lohe
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Vogetseder
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Rüdiger
H
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Moch
P
P
Bode
D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017730:Ki-1 Antigen / Q000235:genetics; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000601:surgery; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D009919:Orchiectomy; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D013737:Testis / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics
D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D017730:Ki-1 Antigen; D050814:Octamer Transcription Factor-3; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins