[Stem cell. New approaches in the treatment of degenerative diseases].
The review describes the mesenchymal and hematopoietic stem cells (SC) of the adult organism. The data on the orthodox and unorthodox ways of cell differentiation was summarized. We discuss various possibilities of stem cells in clinical practice. Particular attention is paid to methods of pharmacological regulation of endogenous SC. Presented their own experimental data on the efficacy of various drugs (neuropharmacological agents, cytokine drugs that alter the structure of the extracellular matrix compounds, pegylated polyethylene glycol to the biologically active compounds) on models of fibrosis and myelosuppression, influencing the function of stem cells.
A M
AM
Dygaĭ
E G
EG
Skurikhin
D000818:Animals; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005355:Fibrosis / Q000473:pathology / Q000628:therapy; D006412:Hematopoietic Stem Cells; D006801:Humans; D059630:Mesenchymal Stem Cells