Protective efficacy of ellagic acid on glycoproteins, hematological parameters, biochemical changes, and electrolytes in myocardial infarcted rats.
The cardioprotective property of ellagic acid in rats has been reported previously. The present study reveals the protective role of ellagic acid in biochemical parameters including serum iron, plasma iron binding capacity, uric acid, glycoprotein, and electrolytes along with hematological parameters. Rats were subcutaneously injected with isoproterenol (ISO) (100 mg/kg) for 2 days to induce myocardial infarction. ISO-induced rats showed a significant increase in their levels of serum iron, serum uric acid, and blood glucose, and a significant decrease in their levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, and heart glycogen, when compared with normal control rats. The altered hematological parameters were also observed in ISO-induced rats when compared with normal control rats. Pretreatment with ellagic acid at doses of 7.5 and 15 mg/kg produced significant beneficial effect by returning all the above-mentioned biochemical and hematological parameters to near normal levels.
SASTRA University, Thirumalaisamudram, Thanjavur, India.
M Mari
MM
Kannan
S Darlin
SD
Quine
T
T
Sangeetha
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001798:Blood Proteins / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004573:Electrolytes / Q000097:blood; D004610:Ellagic Acid / Q000494:pharmacology*; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D007545:Isoproterenol; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D051381:Rats; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D002316:Cardiotonic Agents; D004573:Electrolytes; D006023:Glycoproteins; D004610:Ellagic Acid; D014527:Uric Acid; D007501:Iron; D007545:Isoproterenol