Distinct patterns of antiamyloid-β antibodies in typical and atypical Alzheimer disease.
OBJECTIVE
To compare serum antiamyloid-β (Aβ) antibodies in typical and atypical Alzheimer disease (AD).


METHODS
Preliminary observations.


METHODS
Thirteen patients with AD, 8 patients with posterior cortical atrophy with evidence of AD (PCA-AD) pathophysiological process by both cerebrospinal fluid (CSF) biomarkers and amyloid imaging, and 12 age-matched control individuals.


METHODS
The class and subclass levels of serum anti-Aβ antibodies were measured using an oligomer-based enzyme-linked immunosorbent assay. This method allowed measuring both free antibodies and, after acidic treatment, the total fraction that includes all antibodies complexed with circulating Aβ40/42 and any cross-reacting antigen.


RESULTS
Anti-Aβ IgG were restricted to the IgG1 and IgG3 subclasses. Their total levels were strikingly lower and more homogeneous in patients with PCA compared with both typical AD and controls, while biomarkers of amyloid deposition (CSF Aβ42 and positron emission tomography amyloid imaging) were similar in patients with AD and patients with PCA.


CONCLUSIONS
Serum anti-Aβ IgG1 and IgG3 antibodies differ between distinct forms of AD. Its significance is discussed for possible implications as immune effectors in the specific pathophysiology of AD variants.
INSERM,UMRS938, St-Antoine Hospital, Paris, France.
Guillaume
G
Dorothée
Michel
M
Bottlaender
Edmond
E
Moukari
Leonardo C
LC
de Souza
Renaud
R
Maroy
Fabian
F
Corlier
Olivier
O
Colliot
Marie
M
Chupin
Foudil
F
Lamari
Stephane
S
Lehéricy
Bruno
B
Dubois
Marie
M
Sarazin
Pierre
P
Aucouturier
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000276:immunology* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid / Q000276:immunology*; D000906:Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000000981:diagnostic imaging; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D011877:Radionuclide Imaging; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D000906:Antibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016875:tau Proteins