[Hydrolytic property and solution stability of NAMI derivative containing nicotinamide].
OBJECTIVE
To study the influence of ligand structure on hydrolysis and solution stability of NAMI derivatives.


METHODS
NAMI type compound 1, trans- [RuCl4 (DMSO) (nica)] Na x 2DMSO (nica, nicotinamide) were prepared. Their hydrolytic mechanism, kinetics and stability were investigated by UV-Vis spectrophotometer.


RESULTS
Similar to NAMI, compound 1 undergoes two well-separated steps chloro-hydrolysis (I chloro-hydrolysis and II chloro-hydrolysis) (step reaction) in pH 7.4 buffer solution; while dimethyl sulfoxide (DMSO) hydrolyze in pH 5.00 acetic buffer solution. The k(obs) and t1/2 for each hydrolytic reaction were determined.


CONCLUSIONS
The stability of compound 1 in acidic solution is much more stable than that of in neutral solution. Nicotinamide in place of imidazole can decrease chloro hydrolytic rate of NAMI derivatives obviously, while the influence on the DMSO hydrolytic process is not so remarkable.
State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Yaohu
Y
Liang
Wei
W
Bi
Han
H
Yan
Guogang
G
Liang
D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004355:Drug Stability; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D009536:Niacinamide / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry
D007093:Imidazoles; D008024:Ligands; D012996:Solutions; D009536:Niacinamide; D012428:Ruthenium; D004121:Dimethyl Sulfoxide