[Progress in calcium regulation in myocardial and vascular ischemia-reperfusion injury].
Ischemia-reperfusion injury (IRI) has been recognized as a serious problem for therapy of cardiovascular diseases. Calcium regulation appears to be an important issue in the study of IRI. This article reviews calcium regulation in myocardial and vascular IRI, including the calcium overload and calcium sensitivity in IRI. This review is focused on the key players in Ca(2+) handling in IRI, including membrane damage resulting in increase in Ca(2+) influx, reverse-mode of Na(+)-Ca(2+) exchangers leading to increased Ca(2+) entry, the decreased activity of sarcoplasmic reticulum (SR) Ca(2+)-ATPase causing SR Ca(2+) uptake dysfunction, and increased activity of Rho kinase. These key players in Ca(2+) homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.
Department of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
Xi
X
He
Xue-Yuan
XY
Bi
Hao
H
Wang
Xiao-Jiang
XJ
Yu
Wei-Jin
WJ
Zang
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006321:Heart / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000378:metabolism
D019831:Sodium-Calcium Exchanger; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium