Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride.
An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Brønsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.
Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. mandai@cc.okayama-u.ac.jp
Hiroki
H
Mandai
Kyouta
K
Murota
Koichi
K
Mitsudo
Seiji
S
Suga
D000085:Acetates / Q000737:chemistry*; D000438:Alcohols / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D010879:Piperazines / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000438:Alcohols; D002712:Chlorides; D010756:Phosphoric Acids; D010879:Piperazines; C081124:acetyl chloride; C007306:triethylenediamine