Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible.
OBJECTIVE
The effect of intermittent parathyroid hormone (PTH[1-34]) treatment on bone regeneration in a rat model of mandibular distraction was evaluated using microcomputed tomography.


METHODS
After a 5-day latency period, mandibles of 18 rats were distracted at 0.2 mm/12 hours for 10 days, and rats in the PTH and control groups received subcutaneous injections of PTH(1-34) at a dosage of 60 μg/kg body weight or a vehicle only, respectively, 3 times a week. The animals were humanely killed after 10 days of distraction and after 1 week and 3 weeks of consolidation.


RESULTS
In reconstructed 3-dimensional images of the distracted mandible, mean bone volumes of the desired region of interest in the PTH group were significantly larger than those in the control group at all time points.


CONCLUSIONS
Intermittent PTH(1-34) treatment enhances new bone formation during mandibular distraction in a rat model, and it may be effective for shortening the consolidation period.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mir Nowazesh
MN
Ali
Tadaharu
T
Kobayashi
Mikako
M
Tanaka
Hayato
H
Ohshima
Sadakazu
S
Ejiri
Chikara
C
Saito
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D021621:Imaging, Three-Dimensional; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000601:surgery*; D023421:Models, Animal; D019857:Osteogenesis, Distraction; D010027:Osteotomy; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D055114:X-Ray Microtomography
D010281:Parathyroid Hormone