Vitamin D receptor polymorphisms in colorectal cancer in New Zealand: an association study.
OBJECTIVE
Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for colorectal cancer (CRC). We investigated the association of three single nucleotide polymorphisms (SNPs) of the VDR gene with CRC in age and gender matched patients and controls of European origin in New Zealand.


METHODS
CRC (N=200) and healthy control (N=200) samples were genotyped for the Fok1 (rs2228570), Taq1 (rs731236) and Cdx2 (rs11568820) polymorphisms using Taqman® SNP genotyping assays. Chi-squared analysis was used to test for overall association of VDR genotype with disease, and by age and gender subgroups.


RESULTS
There were no significant associations of the three VDR SNPs with disease either by allelic frequencies (p=0.43-0.73) or genotypic distribution (p=0.15-0.90). Furthermore, no significant differences for allelic frequencies of the three SNPs were revealed in subgroup analysis by age (above/below median age of 72 yrs; p=0.38-0.91), gender (p=0.22-0.88), or age/gender (p=0.33-0.93)


CONCLUSIONS
We found no evidence to suggest that the VDR SNPs Fok1, Taq1 and Cdx2 influence CRC risk in New Zealand Europeans.
Department of Medicine, University of Otago, Christchurch, New Zealand. Robert.Bentley@otago.ac.nz
Robert W
RW
Bentley
Dayle A
DA
Keown
Richard B
RB
Gearry
Vicky A
VA
Cameron
Jacqui
J
Keenan
Rebecca L
RL
Roberts
Andrew S
AS
Day
D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People / Q000235:genetics
D018167:Receptors, Calcitriol