[Research advances of leukemia mouse hematopoietic stem cell transplantation model].
Mouse model of leukemia hematopoietic stem cell transplantation is the key platform to study leukemia experimental treatment, which has been widely used in anticancer drug screening and in the studies of leukemia pathogenesis and experimental treatment. Transplantation mouse model has several advantages such as short cycle of model establishment, good repetitiveness, and the more stable biological characteristics of the tumor cell lines. The source of leukemia and tumor cell lines, choice of mouse species, the establishment of transplantation model, the recent advances of GVHD model and other aspects of transplantation mouse model are summarized in this review.
Department of Hematology, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province, China.
Yu-Xia
YX
Lu
Xiao-Wen
XW
Tang
Guang-Hua
GH
Chen
D000818:Animals; D004195:Disease Models, Animal; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D007938:Leukemia / Q000601:surgery*; D051379:Mice