Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39.
The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATP-degrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
INSERM; U848; Villejuif, France ; Institut Gustave Roussy; Villejuif, France ; Université Paris Sud; Faculté de Médecine Paris XI; Le Kremlin Bicêtre, France.
Mickaël
M
Michaud
Abdul Qader
AQ
Sukkurwala
Isabelle
I
Martins
Shensi
S
Shen
Laurence
L
Zitvogel
Guido
G
Kroemer