18F-FDG PET/CT useful for the early detection of rapidly progressive fatal interstitial lung disease in dermatomyositis.
Interstitial lung disease (ILD) frequently accompanies polymyositis (PM) and dermatomyositis (DM) and is a major cause of mortality. The rapid diagnosis of ILD is paramount. However, the early changes of presymptomatic ILD are difficult to detect. We present a patient with DM who had positive uptake in the lung of FDG-PET/CT as well as 'mechanic's hands' appearance, increased serum ferritin and serum anti-CADM-140 antibody, all before the detection of ILD by CT. Although aggressive treatment was initiated, the patient died of diffuse alveolar damage. These observations suggest that the pulmonary uptake of (18)F-FDG predicts rapidly progressive ILD in DM.
Department of Medicine, Otsu Municipal Hospital, Japan.
Yoshikata
Y
Morita
Shogo
S
Kuwagata
Noriko
N
Kato
Yoshinori
Y
Tsujimura
Hiromi
H
Mizutani
Mitsuhiro
M
Suehiro
Motohide
M
Isono
D000368:Aged; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D018450:Disease Progression; D042241:Early Diagnosis; D017809:Fatal Outcome; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18