[Clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation].
OBJECTIVE
To study the clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation.


METHODS
275 patients with hepatitis B virus--related acute-on-chronic liver failure were investigated. The patients were divided into familial aggregation and non-familial aggregation group basis on their epidemiological features. Clinical data and biochemical indicators between the two groups were analyzed statistically.


RESULTS
93 of 275 patients (33.82%) case were family aggregation. There was no significant difference compared with chronic hepatitis B patients (38.3%). The mean age of the two groups was 45.98 and 43.61 years old, respectively (P > 0.05). The rates of liver cirrhosis in family aggregation group were significant higher than non-familial aggregation group (73.91% vs 58.24%, p < 0.05). Serum total (TBil) and prothrombin activities (PTA) were no significant difference between the two groups, but ALT level in familial aggregation group was much higher (407.80 U/L vs 256.45 U/L, P 0.05).


CONCLUSIONS
Familial aggregation were not related to acute-on-chronic liver failure in chronic HBV hepatitis patients. But the rate of liver cirrhosis were higher in patients with familial aggregation.
302 Military Hospital, Beijing 100039, China.
Bing
B
Zhu
Yi-Hui
YH
Rong
Hong-Ling
HL
Liu
Ai-Min
AM
Zhang
Hong
H
Zang
Long
L
Xiao
Shao-Li
SL
You
Shao-Jie
SJ
Xin
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D058625:End Stage Liver Disease / Q000209:etiology / Q000235:genetics*; D005190:Family; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
D000410:Alanine Transaminase