A convenient and efficient one-pot conversion of peimisine into cyclopamine.
A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The key steps involve one-pot hydrazination and subsequent Bamford-Stevens reaction. The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be used for the scale-up preparation of cyclopamine.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
Shu-Yan
SY
Zheng
Hong-Sheng
HS
Tan
Jian-Sheng
JS
Tao
Zheng-Wu
ZW
Shen
D000470:Alkaloids / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D031410:Fritillaria / Q000737:chemistry*; D014704:Veratrum Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D014704:Veratrum Alkaloids; C052510:peimisine; C000541:cyclopamine