A hypothesis on chemical mechanism of the effect of hydrogen.
Many studies have shown that hydrogen can play important roles on the antioxidant, anti-inflammatory and other protective effects. Ohsawa et al have proved that hydrogen can electively and directly scavenge hydroxyl radical. But this mechanism cannot explain more new experimental results. In this article, the hypothesis, which is inspired by H2 could bind to the metal as a ligand, come up to explain its extensive biology effect: Hydrogen could regulate particular metalloproteins by bonding (M-H2 interaction) it. And then it could affect the metabolization of ROS and signal transduction. Metalloproteins may be ones of the target molecules of H2 action. Metal ions may be appropriate role sites for H2 molecules. The hypothesis pointed out a new direction to clarify its mechanisms.
Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Gansu Provincial Key Laboratory of Aridland Crop Sciences, Gansu Agricultural University, Lanzhou 730070, China.|Gansu Agricultural University, Anning District, Lanzhou City, Gansu Province, China.
Penghui
P
Shi
Gansu Key Lab of Crop Improvement & Germplasm Enhancement, Gansu Provincial Key Laboratory of Aridland Crop Sciences, Gansu Agricultural University, Lanzhou 730070, China.
Wancang
W
Sun
Inner Mongolia University of Science and Technology, School of Material and Metallurgy, Baotou 014010, China.
Pengzhong
P
Shi