What is the influence of vaccination's routes on the regression of tumors located at mucosal sites?
Tumor-regressions following tumor-associated-antigen vaccination in animal models contrast with the limited clinical outcomes in cancer patients. Most animal studies however used subcutaneous-tumor-models and questions arise as whether these are relevant for tumors growing in mucosae; whether specific mucosal-homing instructions are required; and how this may be influenced by the tumor.
Department of Urology; Centre Hospitalier Universitaire Vaudois; Lausanne, Switzerland.
Denise
D
Nardelli-Haefliger
Pedro
P
Romero
Patrice
P
Jichlinski