Primary care management of tuberous sclerosis complex in children.
OBJECTIVE
To provide primary care providers with a general overview of the genetic disorder tuberous sclerosis complex (TSC). By understanding the disease mechanism for this genetic condition, providers can effectively care for TSC patients and properly educate families who are affected by TSC. The article also describes the multi-system clinical presentation of the disease to assist primary care providers with an early diagnosis.


METHODS
Research articles and evidence-based guidelines found through MEDLINE and the World Wide Web.


CONCLUSIONS
Using various diagnostic tools and treatment options, providers can offer the multidisciplinary approach needed to manage this disease appropriately. New treatment options, such as rapamycin, may be the future drug of choice in treating TSC.


CONCLUSIONS
By following evidence-based clinical practice guidelines, providers can hope to reduce TSC-related morbidity and mortality.
Columbia University, School of Nursing, New York, New York 10032, USA. dmanohara@gmail.com
Deepa
D
Manohara
D002648:Child; D002669:Child Welfare; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000451:nursing; D010371:Pediatric Nursing / Q000379:methods*; D011320:Primary Health Care / Q000379:methods*; D012640:Seizures / Q000188:drug therapy; D020123:Sirolimus / Q000627:therapeutic use; D014402:Tuberous Sclerosis / Q000150:complications / Q000175:diagnosis / Q000451:nursing*
D007166:Immunosuppressive Agents; D020123:Sirolimus