[Glial satellites as the source of additional energy supply to the neurons during the increased frequency of firing activity].
Using surviving slices of guinea pig somatosensory cortex, it was shown that functionally different regulation of spontaneous firing activity in different neurons corresponded to irregular distribution of glial satellites. Maximal increase of spike activity induced by acetylcholine (up to 36 spikes per second) was detected in "silent" neurons which account for 37.2% of nerve cells in layer V. According to the morphometric analysis, the same relative number of neurons (38.6%) were surrounded with glial satellites. In spontaneously active neurons only a small elevation of firing activity (5-22 spikes per second) above the basal level was recorded. The results allow to suggest that M-cholinergic reaction, controlling the spontaneous activity level, requires the additional energy supply for its maximal expression in inactive neurons. This is achieved by contacts of neurons with the surrounding glial satellites.
N V
NV
Pasikova
Iu S
IuS
Mednikova
D N
DN
Voronkov
R M
RM
Khudoerkov
F V
FV
Kopytova
D000109:Acetylcholine / Q000008:administration & dosage*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001931:Brain Mapping; D004734:Energy Metabolism; D006168:Guinea Pigs; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D013003:Somatosensory Cortex / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure
D000109:Acetylcholine