Cancer cells use exosomes as tools to manipulate immunity and the microenvironment.
Exosomes are small vesicles secreted in relative abundance by cancer cells, which may prove useful as disease markers. However, exosomes also exhibit potent functions; modulating the behavior of immune- and other cells. Bridging our understanding of their molecular phenotype and functional mechanisms will provide key insight into their importance in cancer.
Department of Pharmacology, Oncology and Radiology, School of Medicine; Cardiff University; Velindre Cancer Centre; Whitchurch, Cardiff UK.
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Clayton