2,4,6-Trichloro-1,3,5-triazine (TCT) mediated one-pot sequential functionalisation of glycosides for the generation of orthogonally protected monosaccharide building blocks.
Orthogonally protected monosaccharide building blocks have been prepared using TCT in a one-pot multicomponent transformation. The process involves successive steps of arylidene acetalation, esterification and regioselective reductive acetal cleavage. High regioselectivity, scope for using a broad range of substrates, functional group tolerance, mild reaction conditions, easy handling process and wide application range are a few advantages of the current process.
NPC-microbes, Indian Institute of Integrative Medicine (IIIM), Jammu, India.
Madhubabu
M
Tatina
Syed Khalid
SK
Yousuf
Debaraj
D
Mukherjee
D000080:Acetals / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004951:Esterification; D006027:Glycosides / Q000737:chemistry*; D054879:Halogenation; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014227:Triazines / Q000737:chemistry*
D000080:Acetals; D006027:Glycosides; D009005:Monosaccharides; D014227:Triazines