Pattern and not magnitude of neural activity determines dendritic spine stability in awake mice.
The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines along these stimulated neurons over a period of weeks, we show that the specific pattern, rather than the total amount of activity, determines spine stability in awake mice.
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Ryan M
RM
Wyatt
Elaine
E
Tring
Joshua T
JT
Trachtenberg
D000200:Action Potentials / Q000502:physiology*; D000679:Amygdala / Q000502:physiology; D000818:Animals; D000075402:Channelrhodopsins; D049229:Dendritic Spines / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D019579:Neocortex / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D000075402:Channelrhodopsins