The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis.
Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adipokines and cytokines that are locally released within fat pads. In a recent study published in Nature, Jonker and colleagues identified FGF1 as an important mediator that is selectively induced in fat cells by high-fat diet feeding and established the PPARγ-FGF1 axis as a critical pathway that regulates adipose tissue remodeling and ultimately systemic metabolic homeostasis.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kai
K
Sun
Philipp E
PE
Scherer
D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D059305:Diet, High-Fat; D004734:Energy Metabolism; D016220:Fibroblast Growth Factor 1 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis; D051379:Mice; D018345:Mice, Knockout; D047495:PPAR gamma / Q000378:metabolism*
D054392:Adipokines; D016207:Cytokines; D047495:PPAR gamma; D016220:Fibroblast Growth Factor 1