Celiac disease in subjects with type 1 diabetes mellitus: a prevalence study in western Sicily (Italy).
The association between celiac disease and type 1 diabetes mellitus is well known. Up to now, celiac disease prevalence in children and adults with type 1 diabetes in Sicily has not been reported. The aim of this study was to assess the prevalence of celiac disease in patients with type 1 diabetes mellitus who come from a defined geographical area in western Sicily and to investigate the clinical features of these subjects. The records of 492 consecutive patients with type 1 diabetes mellitus referred in a period of 5 years were analyzed. During the period of the survey, out of 492 patients with type 1 diabetes, 22 (4.5 %) had a previous diagnosis of celiac disease. There were 14 females and 8 males; these patients showed a mean age of 13 years at diabetes onset. Diagnosis of celiac disease was often simultaneous or subsequent to that of diabetes. Autoimmune thyroiditis was coexisting in 8 patients (36 %). Our data confirm, in a Sicilian population, the not unusual association between celiac disease and type 1 diabetes, although prevalence rate is lower than in others Italian studies. Autoimmune thyroiditis is present with high prevalence in these patients. Celiac disease diagnosis often followed onset of type 1 diabetes, particularly in female subjects with a young age at diabetes onset; therefore, in these subjects, an active search for the presence of celiac disease is warranted for many years after appearance of diabetes.
Division of Diabetology, Paolo Borsellino Hospital, Marsala, Italy. drgreco@alice.it
Domenico
D
Greco
Maria
M
Pisciotta
Francesco
F
Gambina
Filippo
F
Maggio
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015551:Autoimmunity; D002446:Celiac Disease / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D015995:Prevalence; D012189:Retrospective Studies; D012802:Sicily / Q000453:epidemiology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult