The negative feedback regulation of TRPV4 Ca2+ ion channel function by its C-terminal cytoplasmic domain.
The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues where it participates in the generation of a Ca(2+) signal and/or depolarization of the membrane potential. Regulation of the abundance of TRPV4 at the cell surface is critical in osmo- and mechanotransduction. In this review, we discussed that the potential effect of Ca(2+) occurs via its action at an intracellular site in the C-terminus of the channel protein by the effect of the modulation on TRPV4 (such as 824 Ser residue phosphorylation), and its regulation for TRPV4 functions related with cell surface spread, wound healing or its polarity reorientation through its differential affinity with actin or tubulin.
Department of Biology Education, Korea National University of Education, Cheongwon, Chungbuk, Republic of Korea.
Jaesun
J
Chun
Sung Hwa
SH
Shin
Sang Sun
SS
Kang
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D050916:TRPV Cation Channels / Q000737:chemistry* / Q000378:metabolism*
D050916:TRPV Cation Channels; D002118:Calcium