Recent progress in structure-based anti-influenza drug design.
Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.
Department of Physics, Florida State University, Tallahassee, FL 32306, USA.
Juan
J
Du
Timothy A
TA
Cross
Huan-Xiang
HX
Zhou
D000998:Antiviral Agents / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy / Q000378:metabolism*; D015394:Molecular Structure; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
D000998:Antiviral Agents; D014764:Viral Proteins