Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes.
BACKGROUND
Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.


OBJECTIVE
To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.


METHODS
Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.


RESULTS
There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.


CONCLUSIONS
This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.
Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, UK.
Katharine C
KC
Pike
Hazel M
HM
Inskip
Sian
S
Robinson
Jane S
JS
Lucas
Cyrus
C
Cooper
Nicholas C
NC
Harvey
Keith M
KM
Godfrey
Graham
G
Roberts
D000328:Adult; D000465:Algorithms; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000032:analysis; D006306:Health Surveys; D006801:Humans; D007223:Infant; D009569:Nitric Oxide / Q000032:analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D011263:Pregnancy Trimester, Third; D012135:Respiratory Sounds / Q000187:drug effects* / Q000503:physiopathology; D012307:Risk Factors; D012882:Skin Tests; D013147:Spirometry; D011795:Surveys and Questionnaires; D006113:United Kingdom / Q000453:epidemiology; D014807:Vitamin D / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood
D016166:Free Radical Scavengers; D014807:Vitamin D; D009569:Nitric Oxide; C104450:25-hydroxyvitamin D