Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network.
A device containing a 3D microchannel network (fabricated using sacrificial melt-spun microfibers) sandwiched between lithographically patterned microfluidic channels offers improved delivery of soluble compounds to a large volume compared to a simple stack of two microfluidic channel layers. With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels.
Massachusetts Institute of Technology, 77 Massachussetts Avenue, The David H. Koch Institute, Cambridge, MA 02139, USA. Lbellan@mit.edu
Leon M
LM
Bellan
Tatiana
T
Kniazeva
Ernest S
ES
Kim
Alla A
AA
Epshteyn
Donald M
DM
Cropek
Robert
R
Langer
Jeffrey T
JT
Borenstein
D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D054802:Molecular Imprinting / Q000295:instrumentation*; D010781:Photography / Q000379:methods*
D004129:Dimethylpolysiloxanes