Subclinical celiac disease and crystal-induced kidney disease following kidney transplant.
Decreased kidney function from kidney deposition of calcium oxalate has been described previously in inflammatory bowel disease and after jejuno-ileal and Roux-en-Y gastric bypass surgeries. Although celiac disease is the most prevalent bowel abnormality associated with intestinal malabsorption, its relationship to high kidney oxalate burden and decreased kidney function has not been established. We report a case of subclinical celiac disease and hyperoxaluria that presented with loss of kidney function as a result of high oxalate load in the absence of overt diarrhea, documented intestinal fat malabsorption, and nephrolithiasis. Subclinical celiac disease is commonly overlooked and hyperoxaluria is not usually investigated in kidney patients. We propose that this entity should be suspected in patients with chronic kidney disease in which the cause of kidney damage has not been clearly established.
Charles & Jane Pak Center for Mineral Metabolism & Clinical Research, University of Texas Southwestern Medical Center, Dallas, USA.
Giovanna
G
Capolongo
Sameh
S
Abul-Ezz
Orson W
OW
Moe
Khashayar
K
Sakhaee
D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000453:epidemiology*; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000209:etiology*; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000378:metabolism; D008286:Malabsorption Syndromes; D026901:Membrane Transport Proteins / Q000378:metabolism; D008875:Middle Aged; D010070:Oxalates / Q000652:urine; D000076988:Sulfate Transporters
D026901:Membrane Transport Proteins; D010070:Oxalates; C439529:SLC26A6 protein, human; D000076988:Sulfate Transporters; D003404:Creatinine