The functional effect of soybean extract and isolated isoflavone on myocardial infarction and ventricular dysfunction: the soybean extract on myocardial infarction.
BACKGROUND
Myocardial infarction is a public health problem. Functional food is an alternative treatment for cardiovascular diseases.


OBJECTIVE
The objective was to analyze the functional and anatomopathological post-myocardial-infarction effects of soybean extract (SE) and isoflavone (IF).


METHODS
Myocardial infarction was induced in adult Wistar rats. After 5 days, an echocardiogram was performed to determine heart rate (HR), ejection fraction (EF), systolic volume (LVESV) and diastolic volume (LVEDV). Animals with ventricular dysfunction (EF<45%) were selected for study. The animals were divided into three groups: control (n=14), SE (n=15) and IF (n=12). The IF group received 120 mg/kg/day isolated IF, and the SE group received 12.52 g/day. After 30 days, a new echocardiogram was performed. A histological exam was carried out to determine the collagen. Activity of biochemical markers [arginase, lactate dehydrogenase (LDH) and malate dehydrogenase] was measured.


RESULTS
The animals of the control, IF and SE groups showed a reduction in EF after the infarction (P=.432, P=.017 and P=.320, respectively). An increase of LVESV and LVEDV was observed in all groups (P=.009, P=.001 and P=.140; and P=.003, P=.008 and P=.205, respectively). A reduction of HR was found in the SE group (P=.020). There was a greater activity of LDH in the SE group. A smaller quantity of mature collagen was found in the region proximal to the myocardial infarction in the SE group.


CONCLUSIONS
A protective effect in the SE group was observed 30 days after the myocardial infarction.
Experimental Laboratory of the Center for Biological and Health Sciences, Pontifical Catholic University of Parana (PUCPR), Brazil.
Ana C
AC
Miguez
Julio C
JC
Francisco
Sílvio H
SH
Barberato
Rossana
R
Simeoni
Dalton
D
Précoma
Vivian Ferreira
VF
do Amaral
Edson
E
Rodrigues
Márcia
M
Olandoski
Lúcia
L
de Noronha
Fernando H
FH
Greca
Katherine Athayde Teixeira
KA
de Carvalho
José Rocha
JR
Faria-Neto
Luiz C
LC
Guarita-Souza
D000818:Animals; D001835:Body Weight; D003094:Collagen / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D004452:Echocardiography; D007529:Isoflavones / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max / Q000737:chemistry*; D018754:Ventricular Dysfunction; D016277:Ventricular Function, Left / Q000187:drug effects
D007529:Isoflavones; D010936:Plant Extracts; D003094:Collagen; D007770:L-Lactate Dehydrogenase