A total synthesis trilogy: calicheamicin γ1(I), Taxol®, and brevetoxin A.
Detailed behind-the-scenes accounts of the total syntheses of calicheamicin γ(1)(I), Taxol(®), and brevetoxin A are discussed with particular emphasis placed on strategies and tactics employed in these campaigns.
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA. kcn@scripps.edu
K C
KC
Nicolaou
Christopher R H
CR
Hale
Christian
C
Nilewski
D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D035964:Oxocins / Q000138:chemical synthesis* / Q000737:chemistry; D017239:Paclitaxel / Q000138:chemical synthesis* / Q000737:chemistry; D000095702:Polyether Toxins
D000617:Aminoglycosides; D001688:Biological Products; D053281:Enediynes; D008387:Marine Toxins; D035964:Oxocins; D017239:Paclitaxel; C055955:calicheamicin gamma(1)I; C076262:Brevetoxin A; D000095702:Polyether Toxins