Organocatalyzed Michael-Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate.
Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.
Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621, Taiwan, R.O.C. chebch@ccu.edu.tw
Bor-Cherng
BC
Hong
Po-Yuan
PY
Chen
Prakash
P
Kotame
Pei-Ying
PY
Lu
Gene-Hsiang
GH
Lee
Ju-Hsiou
JH
Liao