[Benign ethnic neutropenia; an unrecognised cause of leukopenia in negroid patients].
Leukopenia has a high incidence and is usually a reason for additional testing. Benign ethnic neutropenia is a relatively common cause of neutropenia in the negroid population. It can be the cause of aberrant laboratory results in negroid patients. A 55-year-old woman from Ghana was referred to the outpatient clinic because of malaise, leukopenia and neutropenia. Viral infection, haematological malignancy, auto-immune disease and vitamin deficiency were considered, but could not be confirmed by additional testing. Upon further investigation, the neutropenia in this patient was found to have existed for years. Moreover, our patient's son also had asymptomatic leukopenia. Therefore, benign ethnic neutropenia was considered the most likely diagnosis. Serological analysis of the patient's erythrocytes revealed the absence of Duffy (Fy) blood group antigens Fy(a) and Fy(b), which is associated with benign ethnic neutropenia.
Medisch Centrum Alkmaar, Afd. Interne Geneeskunde, the Netherlands.
Cleo R
CR
van Rooijen
Walentina A T
WA
Slieker
Suat
S
Simsek
D044383:Black People; D005260:Female; D005869:Ghana / Q000208:ethnology; D006801:Humans; D007970:Leukopenia / Q000175:diagnosis; D008875:Middle Aged; D009503:Neutropenia / Q000175:diagnosis* / Q000208:ethnology*