Deoxy Derivatives of L-like 5'-Noraristeromycin.
Several base variations of 2'- and 3'-deoxy derivatives of (+)-4'-deoxy-5'-noraristeromycin have been prepared from enantiomerically pure precursors following standard purine nucleoside construction. These carbocyclic nucleosides were evaluated against hepatitis B virus (HBV) and found to be inactive. No cytotoxicity to the cell line was observed.
Elizabeth City State University, Department of Chemistry, Geology, and Physics, Elizabeth city, NC 27909.
Shante
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Hinton
Alecia
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Riddick
Tesfaye
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Serbessa