Height, weight, BMI and ovarian cancer survival.
OBJECTIVE
Ovarian cancer is a highly fatal gynecologic malignancy. Prognosis is primarily based on clinicopathologic features. There is interest in the role of modifiable factors including overweight and obesity, although data to date have been inconclusive. Here we evaluate the relationship between body size and ovarian cancer survival among 1423 women diagnosed with epithelial ovarian cancer in a large population-based study.


METHODS
Information on risk factors and characteristics was collected by telephone. Vital status was determined both by computerized record-linkage and by chart review. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for height, weight and body mass index (BMI) in association with ovarian cancer-specific mortality.


RESULTS
Height, weight and BMI 5 years prior to diagnosis did not significantly predict ovarian cancer survival in this study. The HR for ovarian cancer-specific mortality for women with a weight of >61 kg compared with >50-55 kg was 0.91 (95%CI 0.71-1.20). The HR among women with a BMI≥30 kg/m2 compared to 18.5-<25 kg/m2 was 1.11 (95%CI 0.87-1.42). These findings did not vary by histologic subtype.


CONCLUSIONS
Our results do not support a role of height, adult weight or adiposity in ovarian cancer prognosis.
Women's College Research Institute, Women's College Hospital, 790 Bay Street, 7th Floor, Toronto, Ontario, Canada.
Joanne
J
Kotsopoulos
Joel R K
JR
Moody
Isabel
I
Fan
Barry
B
Rosen
Harvey A
HA
Risch
John R
JR
McLaughlin
Ping
P
Sun
Steven A
SA
Narod
D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000401:mortality* / Q000473:pathology; D009864:Ontario / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D011795:Surveys and Questionnaires