Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis.
Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-(99m)Tc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats that had been treated with these liposomes were performed. A high accumulation in infectious foci and high values in the target-non target ratio could be observed. These results indicate the potential of SpHL-(99m)Tc-CF as a potential agent for the diagnosis of bone infections.
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Soraya Maria Zandim Maciel Dias
SM
Ferreira
Giselle Pires
GP
Domingos
Diego dos Santos
Ddos S
Ferreira
Talita Guieiro Ribeiro
TG
Rocha
Rogéria
R
Serakides
Cleuza Maria
CM
de Faria Rezende
Valbert Nascimento
VN
Cardoso
Simone Odília Antunes
SO
Fernandes
Mônica Cristina
MC
Oliveira
D000818:Animals; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D004195:Disease Models, Animal; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D008297:Male; D015394:Molecular Structure; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D010019:Osteomyelitis / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects
D008081:Liposomes; D015609:Organotechnetium Compounds; C510184:technetium 99m ceftizoxime; D015296:Ceftizoxime