Unleashing a "true" pSer-mimic in the cell.
In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.
Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.
Kaushik
K
Panigrahi
David L
DL
Nelson
David B
DB
Berkowitz