Relationship between serum omentin-1 level and bone mineral density in girls with anorexia nervosa.
BACKGROUND
Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Omentin- 1, the main circulating adipocytokine, plays an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown.


METHODS
Serum omentin-1, bone turnover biochemical markers, and BMD were determined in 26 girls with AN and 24 healthy girls (15-18 years old).


RESULTS
Omentin-1 levels increased in AN subjects, and the differences became greater after controlling for fat mass. Omentin-1 was negatively correlated with BMD. In the multiple linear stepwise regression analysis, omentin-1, body mass index and lean mass, but not fat mass, were independent predictors of BMD for the combined group. Significant negative correlations were found between omentin-1 and bone-specific alkaline phosphatase, bone cross-linked N-telopeptides of type I collagen. Omentin-1 was also independently associated with BMD and bone turnover markers in the AN and control groups considered separately.


CONCLUSIONS
Omentin-1 was an independent predictor of BMD in adolescents with AN, and negatively correlated with bone turnover markers. This suggested that omentin-1 may exert a negative effect on bone mass by inhibiting bone formation in girls with AN.
Department of Endocrinology, Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
L-J
LJ
Guo
T-J
TJ
Jiang
L
L
Liao
H
H
Liu
H-B
HB
He
D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D020738:Leptin / Q000097:blood; D012044:Regression Analysis
C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D020738:Leptin