[Application of ADME process in vivo in combination with network pharmacology in study of traditional Chinese medicine].
Application of network pharmacology in traditional Chinese medicine (TCM) will be benefit for clarifying active components and mechanism of action of TCM and increase the study level of new drug of Chinese medicine. ADME process can identify drug components from TCM and obtain the possible metabolites which can clarify active components in vivo. For the complexity of active constituents of TCM, it indicated that the ADME process will be the precondition for application of network pharmacology in TCM. This paper introduced the study ideas of the combination of ADME process in vivo and network pharmacology.
Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. hy_xu627@163.com
Haiyu
H
Xu
Luqi
L
Huang
Peng
P
Lu
Hongjun
H
Yang
D016503:Drug Delivery Systems / Q000379:methods; D004358:Drug Therapy / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D010600:Pharmacology / Q000379:methods*
D004365:Drugs, Chinese Herbal