[Chemical constituents from Corydalis yanhusuo].
OBJECTIVE
To investigate the chemical constituents of Corydalis yanhusuo.


METHODS
The compounds were isolated and purified by column chromatography over macroporous absorption resin, silica gel, and Sephadex LH-20. Their structures were elucidated on the basis of physicochemical properties and spectral data.


RESULTS
22 compounds were isolated and identified as corydaline (1), tetrahydropalmatine (2), protopine (3), tetrahydrocorysamine (4), tetrahydrocoptisine (5) , tetrahydroberberine (6), tetrahydrocolumbamine (7), noroxyhydrastine (8), dehydrocorydaline (9), glaucine (10), columbamine (11), 8-oxocoptisine (12), 13-methyl-columbamine (13), coptisine (14), palmatine (15), herberine (16), oxoglaucine (17), 13-methyl-palmatrubine (18), dehydrocorybulbine (19), stepharanine (20), adenosine (21), and N5 -acetylornithine (22).


CONCLUSIONS
Compounds 13, 20, 21, and 22 were isolated from this plant for the first time.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Ziming
Z
Lu
Wuxing
W
Sun
Xuhong
X
Duan
Zhiyun
Z
Yang
Yadong
Y
Liu
Pengfei
P
Tu
D000241:Adenosine / Q000032:analysis / Q000302:isolation & purification; D000470:Alkaloids / Q000032:analysis / Q000302:isolation & purification; D001058:Apomorphine / Q000031:analogs & derivatives / Q000032:analysis / Q000302:isolation & purification; D001060:Aporphines / Q000032:analysis / Q000302:isolation & purification; D001599:Berberine / Q000032:analysis / Q000302:isolation & purification; D001600:Berberine Alkaloids / Q000032:analysis / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000379:methods; D031311:Corydalis / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis* / Q000302:isolation & purification*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
C539140:13-methyl-palmatrubine; D000470:Alkaloids; D001060:Aporphines; D001600:Berberine Alkaloids; D010936:Plant Extracts; C452799:corydaline; D001599:Berberine; C007232:dehydrocorydalin; C014215:tetrahydropalmatine; C111587:oxoglaucine; C055786:columbamine; D000241:Adenosine; C092892:tetrahydrocolumbamine; D001058:Apomorphine; C005004:glaucine