Anti-inflammatory and anti-atherogenic properties of adiponectin.
Obesity-related disorders, such as insulin resistance, hypertension and atherosclerosis, are associated with chronic inflammation. Adiponectin is an adipocyte-derived secreted factor that is down-regulated in obese states. Adiponectin exerts the protective actions on obesity-linked diseases, such as insulin resistance and atherosclerosis by attenuating chronic inflammation in its target organs. Adiponectin also exerts the salutary effects on vascular disorders by directly acting on vascular component cells including endothelial cells, smooth muscle cells and macrophages. This review will focus on the role of adiponectin in control of inflammatory responses and atherogenic processes.
Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-Ku, Nagoya, Japan. ohashik@med.nagoya-u.ac.jp
Koji
K
Ohashi
Noriyuki
N
Ouchi
Yuji
Y
Matsuzawa
D052242:Adiponectin / Q000378:metabolism*; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000517:prevention & control*; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000517:prevention & control*; D008264:Macrophages / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism
D052242:Adiponectin