Hypereosinophilic syndrome in children.
Recently, according to the Hypereosinophilic Diseases Working Group of the International Eosinophil Society, six variants of hypereosinophilic syndrome have been proposed, i.e. (1) myeloproliferative, (2) lymphoproliferative, (3) idiopathic/undefined, (4) overlapping, (5) associated and (6) familial variant. Hypereosinophilic syndrome is a rare disorder in children and can occur at any age during childhood. Corticosteroids are the treatment of choice, whereas other treatment options are hydroxyurea, IFNα, imatinib, vincristine, mepolizumab. We present a fulminant fatal case of hypereosinophilic syndrome in a teenager with an initial presentation of an idiopathic thrombocytopenia (ITP) and present a narrative review of literature.
Department of Pediatric Oncology-Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands. m.vangrotel@erasmusmc.nl
M
M
van Grotel
M
M
de Hoog
R R
RR
de Krijger
H B
HB
Beverloo
M M
MM
van den Heuvel-Eibrink
D000293:Adolescent; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000473:pathology* / Q000628:therapy*; D012196:Review Literature as Topic