Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy.
Antibody-dependent cell cytotoxicity (ADCC) is critical in monoclonal antibody (mAb)-mediated cancer therapy. We recently showed that a tumor-specific mAb in combination with cyclophosphamide inhibited tumor cell growth and induced ADCC-synapses between tumor and effector cells in vivo, opening perspectives to enhance anti-tumor responses by manipulating the immune system.
Institut Curie; Centre de Recherche; Paris, France ; INSERM; U93; Paris, France.
Pascale
P
Hubert
Sebastian
S
Amigorena