[Research of xuebijing injection combined with glucocorticoid in treating dermatitis medicamentosa like of trichloroethylene with systemic inflammatory response syndrome].
OBJECTIVE
To study the better efficacy of clinic treatment for dermatitis medicamentosa like of trichloroethylene (DMLT) and observe the clinic efficacy of Xuebejing injection for DMLT patients with systemic inflammatory response syndrome (SIRS).


METHODS
16 DMLT patients with SIRS were randomly divided into control group (conventional therapy) and xuebijing group (conventional therapy plus xuebijing). We evaluated all the patients with APACHE II before treatment and checked the TNF-alpha in blood at the different time (before treatment and the 7th day of treatment). The total usages, first dosage of medrol and the time of therapy for each group were counted.


RESULTS
All patients were cured, there was no significant difference according to APACHE II and TNF-alpha before treatment in two groups . The level of TNF-alpha of all the patients were decreased markedly, but more significantly in xuebijing group (P < 0.01). Moreover, the treatment group patients were given relatively less total usages, first dosage of medrol and time of therapy (P < 0.01).


CONCLUSIONS
Xuebejing injection combined glucocorticoids can cure DMLT patients with SIRS effectively, and reduce the total usages, first dosage of medrol and time of therapy.
Shenzhen hospital for the Prevention and Treatment of Occupational Disease, Shenzhen 518000, China.
Jin-Lin
JL
Wang
Jian-Jie
JJ
Zhang
Shao-Hong
SH
Qiu
Li-Hua
LH
Deng
D018806:APACHE; D000293:Adolescent; D000328:Adult; D003875:Drug Eruptions / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014241:Trichloroethylene / Q000633:toxicity*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha; C549376:Xuebijing; D014241:Trichloroethylene