Cycloartane-type triterpenes from the leaves of Homonoia riparia with VEGF-induced angiogenesis inhibitory activity.
Six new cycloartane-type triterpenes (1-6), 24-methylenecycloartane-3β,6β,7β-triol (1), 24-methylenecycloartane-3β,6β,7β,16β-tetraol (2), 24-methylenecycloartane-3β,6β,16β-triol (3), 24-methylenecycloartane-3β,7β,16β-triol 3-O-β-d-xylopyranoside (4), 24-methylenecycloartane-3β,6β,16β-triol 3-O-β-d-xylopyranoside (5), and 24-methylenecycloartane-3β,6β,7β-triol 3-O-β-d-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartane-3β,6β,7β,16β-tetraol 3-O-β-d-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.
Herbal Medicine Research Division,  Korea Institute of Oriental Medicine , Daejeon 305-811, Republic of Korea.
IkSoo
I
Lee
Junghyun
J
Kim
Young Sook
YS
Kim
Nam Hee
NH
Yoo
Chan-Sik
CS
Kim
Kyuhyung
K
Jo
Joo-Hwan
JH
Kim
Tran The
TT
Bach
Jin Sook
JS
Kim
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D019665:Euphorbiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology*; D014744:Vietnam
D020533:Angiogenesis Inhibitors; D014315:Triterpenes; D042461:Vascular Endothelial Growth Factor A; C085352:cycloartane