[Liver, lung, kidney, heart and spleen structure of rats after multiple intravenous injections of magnetite nanosuspension].
Effects of multiple intravenous magnetite nanosuspension injections on the structure of rat liver, lungs, kidney, heart and spleen have been studied. Histology of the organs listed have found haemodynamic distortions and necrotic lesions in the parenchyma of these organs. With the help of Pearls histochemical method significant piling of nanoparticles were found in the cells of the mononuclear phagocytes in liver, lungs and spleen of the rats. Only singular Pearls-positive cells were found in kidneys and hearts of the rats.
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Sukhodolo
D000818:Animals; D006321:Heart / Q000187:drug effects*; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000008:administration & dosage*; D008297:Male; D009206:Myocardium / Q000473:pathology; D010586:Phagocytes / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D013535:Suspensions
D058185:Magnetite Nanoparticles; D013535:Suspensions