The physiology of cardiac calcium handling.
Cardiac calcium (Ca(2+)) handling subsumes the mechanisms maintaining the myocardial Ca(2+) homeostasis that contribute essentially to cardiac performance. This review addresses the interaction of transplasmalemmal and transsarcoplasmic Ca(2+) flux, its potential modifications due to β-adrenergic stimulation and its implications on cardiac action potential.
Division of Clinical and Experimental Rhythmology, Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany. nils.boegeholz@googlemail.com
Nils
N
Bögeholz
Adam
A
Muszynski
Christian
C
Pott
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology; D006331:Heart Diseases / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000502:physiology; D019831:Sodium-Calcium Exchanger / Q000502:physiology
D015220:Calcium Channels; D011943:Receptors, Adrenergic, beta; D019831:Sodium-Calcium Exchanger; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D002118:Calcium