Bioactivity and viscoelastic characterization of chitosan/bioglass® composite membranes.
Membranes of chitosan (CTS) and composite membranes of CTS with bioglass are prepared by solvent casting. The composite membranes are shown to induce the precipitation of apatite upon immersion in SBF. The biomineralization process is followed by measuring the variation of the viscoelastic properties of the membranes immersed in SBF, both online and offline. Non-conventional DMA is used to measure the change in the storage modulus, E', and the loss factor, tan δ, as a function of the immersion in SBF. A simple model is used to estimate the E' of the apatite layer formed in vitro that is about 130 MPa. This work shows that innovate mechanical tests can be useful to characterize the mechanical performance of composites under physiological conditions.
3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, 4806-909 Taipas, Guimarães, Portugal. sofia.caridade@dep.uminho.pt
Sofia G
SG
Caridade
Esther G
EG
Merino
Natália M
NM
Alves
João F
JF
Mano
D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D040761:Biomimetic Materials; D001826:Body Fluids / Q000737:chemistry; D002516:Ceramics / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014783:Viscosity
D001031:Apatites; D001672:Biocompatible Materials; C022107:Bioglass; D008567:Membranes, Artificial; D048271:Chitosan