Incidence of malignancy after living kidney transplantation: a multicenter study from iran.
Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59% of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2%. Kaposis' sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95% CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation.
1. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Behzad
B
Einollahi
Zohreh
Z
Rostami
Mohammad Hossein
MH
Nourbala
Mahboob
M
Lessan-Pezeshki
Naser
N
Simforoosh
Eghlim
E
Nemati
Vahid
V
Pourfarziani
Fatemeh
F
Beiraghdar
Mohsen
M
Nafar
Fatemeh
F
Pour-Reza-Gholi
Mitra Mahdavi
MM
Mazdeh
Manochehr
M
Amini
Pedram
P
Ahmadpour
Khadijeh
K
Makhdoomi
Ali
A
Ghafari
Mohammad Reza
MR
Ardalan
Hamid Taebi
HT
Khosroshahi
Farshid
F
Oliaei
Shahrzad
S
Shahidi
Shahin
S
Abbaszadeh
Mohammad Reza
MR
Fatahi
Fatemeh
F
Hiedari
Atehieh
A
Makhlogh
Jalal
J
Azmandian
Hamid Reza
HR
Samimagham
Heshmatollah
H
Shahbazian
Fatemeh
F
Nazemian
Massih
M
Naghibi
Masoud
M
Khosravi
Ali
A
Monfared
Seyed Majid
SM
Mosavi
Javad
J
Ahmadi
Mojgan
M
Jalalzadeh