[Comparison of effects of badu shengji san on rats with different injured skins].
OBJECTIVE
To compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins.


METHODS
The injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity.


RESULTS
Compared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise.


CONCLUSIONS
The renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yanli
Y
Lu
Rong
R
He
Bo
B
Peng
Qihua
Q
Xu
Xuhui
X
Zhang
Han
H
Lin
Jianrong
J
Li
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008628:Mercury / Q000633:toxicity* / Q000652:urine; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012177:Retinol-Binding Proteins / Q000652:urine; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D012883:Skin Ulcer / Q000188:drug therapy* / Q000382:microbiology; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D012177:Retinol-Binding Proteins; D000118:Acetylglucosaminidase; D008628:Mercury