[Influence of intravenous injection of fucoidan from brown seaweed Fucus evanescens by plasma rabbits anticoagulant activity and neutralisation by sulphate protamin of fucoidans antithrombin activity in vitro].
With fucoidan from Fucus evanescens dose increase from 1 to 5 mg/kg plasma coagulation time in test A(see symbol)TB increases. Sulphate protamin in final concentration 0.67-1.35 mkg/ml will neutralise antithrombin activity of fucoidans from brown seaweed Fucus evanescens and Laminaria cichorioides. The gravimetrichesky relation for the investigated samples makes an antidot/anticoagulant 1.
E S
ES
Lapikova
N N
NN
Drozd
V A
VA
Makarov
T N
TN
Zviagintseva
N M
NM
Shevchenko
T A
TA
Kuznetsova
N N
NN
Besednova
D000818:Animals; D000925:Anticoagulants / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D004336:Drug Antagonism; D005343:Fibrinolytic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D044645:Fucus / Q000737:chemistry*; D006494:Heparin Antagonists / Q000493:pharmacokinetics* / Q000494:pharmacology; D011134:Polysaccharides / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D011479:Protamines / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics* / Q000494:pharmacology; D011817:Rabbits
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006494:Heparin Antagonists; D011134:Polysaccharides; D011479:Protamines; C007789:fucoidan