[Genetic aspects in nicotine dependence].
Genetic epidemiology of smoking and nicotine dependence has been studied for decades. Twin, family and adoption studies show evidence for genetic effects on smoking and nicotine dependence. Gene-environment interactions exist, such as parental monitoring moderating genetic vulnerability for smoking. Molecular genetic analyses have identified a few genes associated with the amount smoked and nicotine dependence. Genome-wide association studies have identified some nicotine dependence genes. The nicotinic receptor alpha 5 gene variant associated with nicotine dependence is functional. Studies with sophisticated phenotypes, larger samples and better environment measures are needed.
Helsingin yliopisto, Hjelt instituutti, PL 41, 00014 Helsinki.
Tellervo
T
Korhonen
Jaakko
J
Kaprio
D016021:Epidemiologic Studies; D059647:Gene-Environment Interaction; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D010641:Phenotype; D011978:Receptors, Nicotinic / Q000235:genetics; D012907:Smoking / Q000453:epidemiology / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000453:epidemiology / Q000235:genetics*
D011978:Receptors, Nicotinic