The double-edge sword effect of anti-CD73 cancer therapy.
We and others have identified CD73 as a new cancer target. I hereafter discuss that targeted blockade of CD73 has the effect of a "double-edge sword," able on the one hand to rescue endogenous adaptive anti-tumor immune responses, and on the other hand, inhibit the metastatic potential of tumor cells.
Centre de Recherche du Centre Hospitalier de l'Université de Montréa; Faculté de Pharmacie et Institut du Cancer de Montréal; Montréal, Québec, Canada.
John
J
Stagg