[Comparative evaluation of therapeutic efficacy of early amnion covering the cornea, temporary blepharorrhaphy and its combination in severe alkali burns of the eye in the experiment].
In four groups of rabbits on model of a heavy alkaline burn of a cornea and a limbus of various extent character and outcomes of healing of an eye surface as a result of early (it is direct after a burn) applications is investigated: only conservative treatment - group I, conservative treatment + time blepharorrhaphy - group II, conservative treatment + covering of a cornea and a limbus of amnionic membrane - group III, and also combinations of conservative treatment, temporary of blepharorrhaphy and coverings of a cornea and a limbus amnionic membrane - group IV. In all groups conservative treatment included: an instillation of maxitrol within 14 days with transition to a mortgaging of Unguentum Tetracyclini of 1% 3 times a day. Depending on width of sector of the burn measured in circular degrees, each group included 4 subgroups: 60° - a subgroup "A", 120° " " - 180° - "B", 270° "Γ" - (on 4 eyes in a subgroup). Results estimated daily within the first 10 days, and further every 5 days (during 3 months) after a burn with photoregistration at colouring of an eye surface of 1% a solution fluorescein-natrium. On the basis of the received results it is established that the early fortnight time blepharorrhaphy (as addition to conservative treatment) is the most effective and accessible method (from considered) optimisation of healing of an eye surface at heavy burns of eyes with capture to 75% of the area of a cornea and a limbus.
É V
ÉV
Boĭko
S V
SV
Churashov
V F
VF
Chernysh
A S
AS
Rud'ko
D000468:Alkalies / Q000009:adverse effects*; D000818:Animals; D001684:Biological Dressings; D002057:Burns, Chemical / Q000473:pathology / Q000628:therapy*; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D065306:Corneal Injuries; D011817:Rabbits; D012720:Severity of Illness Index; D013997:Time Factors
D000468:Alkalies