Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue.
The advent of the obesity epidemic has highlighted the need to re-assess more closely the pathophysiology of obesity-related hypertension with the aim of identifying new therapies. In this article, we review the role of the renin-angiotensin-aldosterone system, sympathetic nervous system, and inflammation in relation to the pathophysiology of this condition. We also discuss the potential role of the perivascular adipose tissue in the context of obesity-related hypertension.
Cardiovascular Research Group, University of Manchester, UK.
Reza
R
Aghamohammadzadeh
Anthony M
AM
Heagerty
D000273:Adipose Tissue / Q000378:metabolism*; D001808:Blood Vessels / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D007249:Inflammation / Q000150:complications; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D012084:Renin-Angiotensin System; D013564:Sympathetic Nervous System / Q000378:metabolism
D017382:Reactive Oxygen Species