Effect of HMG-CoA reductase inhibitors on antimicrobial susceptibilities for gram-negative rods.
Epidemiologic evidence suggests a beneficial effect of HMG-CoA reductase inhibitors (statins) in sepsis, and in-vitro data exist for antimicrobial activity of statins against some bacteria and fungi. We examined whether statin exposure at physiologic concentrations enhances activity of selected antimicrobials against Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Broth microdilution was performed with and without dose-ranging concentrations of lovastatin, fluvastatin, atorvastatin, pravastatin and simvastatin. No effects on antimicrobial activity were demonstrated.
Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX, USA. aaron.farmer@amedd.army.mil
Aaron R
AR
Farmer
Clinton K
CK
Murray
Katrin
K
Mende
Kevin S
KS
Akers
Wendy C
WC
Zera
Miriam L
ML
Beckius
Heather C
HC
Yun
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004347:Drug Interactions; D016946:Gram-Negative Aerobic Rods and Cocci / Q000187:drug effects*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors