Cell-free screening for NOX inhibitors.
NOX enzymes are major ROS generators in pathological states and represent a promising pharmacological target. In this issue of Chemistry & Biology, Smith and colleagues developed an original and elegant cell-free assay to identify specific Nox2 inhibitors in a high throughput manner.
Department of Pathology, Dalhousie University, Halifax, B3H 4R2, Canada.
Karen
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Bedard
Vincent
V
Jaquet