Diffuse tubulointerstitial nephritis accompanied by renal crystal formation in an HIV-infected patient undergoing highly active antiretroviral therapy.
This report presents a human immunodeficiency virus (HIV) patient that developed a slowly progressive renal impairment over years under highly active antiretroviral therapy (HAART). The renal biopsy showed diffuse tubulointerstitial nephritis accompanied by crystal formations that were surrounded by multinuclear giant cells. Furthermore, rod-like crystals were detected in the urinary sediments. Tenofovir and Atazanavir were thought to be the causative drugs for the renal injury. Therefore, the possibility of HARRT-induced nephrotoxicity should be considered in HIV-infected patients, even though the activity of HIV is controlled by such therapies.
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan. g-kanzaki@jikei.ac.jp
Go
G
Kanzaki
Nobuo
N
Tsuboi
Yoichi
Y
Miyazaki
Takashi
T
Yokoo
Yasunori
Y
Utsunomiya
Tatsuo
T
Hosoya
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003460:Crystallization; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced / Q000473:pathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology / Q000652:urine; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000473:pathology / Q000652:urine