[Mitochondria couple cellular Ca(2+) signal transduction].
It has been shown that mitochondria not only control their own Ca(2+) concentration ([Ca(2+)]), but also exert an influence over Ca(2+) signaling of the entire cell, including the endoplasmic reticulum or the sarcoplasmic reticulum, the plasma membrane, and the nucleus. That is to say, mitochondria couple cellular metabolic state with Ca(2+) transport processes. This review focuses on the ways in which the mitochondrial Ca(2+) handling system provides integrity and modulation for the cell to cope with the complex actions throughout its life cycle, enumerates some indeterminate aspects about it, and finally, prospects directions of future research.
Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou, China.
Ya-Man
YM
Song
Zhong-Qiu
ZQ
Lu
Min-Xin
MX
Guan
D001692:Biological Transport; D020013:Calcium Signaling; D002462:Cell Membrane / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000502:physiology