Advancing management of hypertension through pharmacogenomics.
Hypertension is the most common, chronic disease in the world, and there are many effective pharmacological agents available for its treatment. Despite the plethora of treatment options, data across the globe suggest that blood pressure control rates are < 50%, a fact likely influenced in part by the inability to predict the antihypertensive drug likely to be most effective for an individual patient. Pharmacogenomics in hypertension holds the promise of identifying genetic biomarkers for antihypertensive drug response, which might be used in the future in treatment selection. Research in the field is also likely to enhance our understanding of hypertension and the mechanisms by which the various drugs produce efficacy. There are several examples in the literature of genes with relatively strong data on associations of genetic polymorphisms with antihypertensive response; the data on ADRB1, CACNB2, and NEDD4L are detailed as examples. Substantial additional data in hypertension pharmacogenomics are expected to be forthcoming from recently completed genome-wide association studies. Increased collaboration among research groups will help insure successful discoveries from these large-scale studies. The next decade should clearly define the potential clinical implications of the research in hypertension pharmacogenomics that is currently in progress.
Colleges of Pharmacy and Medicine and Center for Pharmacogenomics, University of Florida, Gainesville, Florida 100486, USA. Johnson@cop.ufl.edu
Julie A
JA
Johnson
D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics; D020746:Calcium Channels, L-Type / Q000235:genetics; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics*; D000075702:Nedd4 Ubiquitin Protein Ligases; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
C547787:ADRB1 protein, human; C107597:CACNB2 protein, human; D020746:Calcium Channels, L-Type; D056827:Endosomal Sorting Complexes Required for Transport; D018342:Receptors, Adrenergic, beta-1; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618485:Nedd4L protein, human; D044767:Ubiquitin-Protein Ligases