The first full-length endogenous hepadnaviruses: identification and analysis.
In silico screening of metazoan genome data identified multiple endogenous hepadnaviral elements in the budgerigar (Melopsittacus undulatus) genome, most notably two elements comprising about 1.3 × and 1.0 × the full-length genome. Phylogenetic and molecular dating analyses show that endogenous budgerigar hepatitis B viruses (eBHBV) share an ancestor with extant avihepadnaviruses and infiltrated the budgerigar genome millions of years ago. Identification of full-length genomes with preserved key features like ε signals could enable resurrection of ancient BHBV.
Key Laboratory of Medical Molecular Virology (MOH & MOE) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wei
W
Liu
Shaokun
S
Pan
Huijuan
H
Yang
Weiya
W
Bai
Zhongliang
Z
Shen
Jing
J
Liu
Youhua
Y
Xie
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016679:Genome, Viral; D015613:Hepadnaviridae / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018347:Hepadnaviridae Infections / Q000662:veterinary* / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011533:Proviruses / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
D014764:Viral Proteins