Invariant natural killer T cells reconstitution and the control of leukemia relapse in pediatric haploidentical hematopoietic stem cell transplantation.
CD1d-restricted invariant (i)NKT cells are innate-like, lipid-reactive T lymphocytes implicated in the control of infections, cancer and autoimmunity. Our study suggests that the reconstitution of the peripheral iNKT cell compartment, following HLA-haploidentical hematopoietic stem cell transplantation, associates with leukemia control in children affected by different hematological malignancies.
Experimental immunology Unit; Division of Immunology; Transplantation and Infectious Diseases; San Raffaele Scientific Institute; Milano, Italy.
Giulia
G
Casorati
Claudia
C
de Lalla
Paolo
P
Dellabona