Gastric antral vascular ectasia (GAVE) in a non-cirrhotic patients with diabetes: case report and possible pathophysiological mechanism.
Gastric antral vascular ectasia (GAVE) syndrome is an uncommon but well-described cause of recurrent upper gastrointestinal bleeding or iron deficiency anaemia. Atiology is unknown but several associated diseases have been reported like connective tissue or autoimmune disorders or cirrhosis. Cases have been reported in systemic sclerosis, achlorhydia, atrophic gastritis and chronic renal failure. The most common cause is portal hypertension and portal hypertensive gastropathy. This is especially so after eradication of oesophageal varices by sclerotherapy or banding. Diabetic complications are characterised by microvascular diseases especially in the retina, glomerulus and vasa nervorum. It involves apoptosis and remodelling of endothelial cells. Hyperglycaemia is an essential cause of reactive oxygen species (ROS)-mediated oxidative stress in this complication. Angiopathy of gastric mucosa in diabetes mellitus has not been reported so far in the literature. We are presenting an interesting case of diabetes mellitus with gastric vascular ectasia without evidence of any other systemic illness.
Hera General Hospital, Makkah, Saudi Arabia. dr_wani_majid@yahoo.co.in
Abdul Majid
AM
Wani
Waleed Mohd
WM
Hussain
Abdulhakeem
A
Banjar
Wail H
WH
Almaimani
Jamal Talaat
JT
Hamdi
Khalid J
KJ
Hamdi
Amer Mohd
AM
Khoujah
Mubeena
M
Akhtar
D000328:Adult; D048909:Diabetes Complications / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D020252:Gastric Antral Vascular Ectasia / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D008028:Light Coagulation
D007501:Iron