DNA repair polymorphisms in B-cell chronic lymphocytic leukemia in sufferers of Chernobyl Nuclear Power Plant accident.
An association between DNA repair gene polymorphisms, environmental factors, and development of some types of cancer has been suggested by several studies. Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the clean-up workers of the Chernobyl Nuclear Power Plant (NPP) accident and it has some specific features. Therefore, we have studied the possible differences in DNA repair gene polymorphisms in CLL patients depending on ionizing radiation (IR) exposure history and their clinical characterictics. Arg399Gln XRCC1, Thr241Met XRCC3, and Lys751Gln XPD polymorphisms were studied in 64 CLL patients, exposed to IR due to the Chernobyl NPP accident, 114 IR-non-exposed CLL patients, and 103 sex- and age-matched IR-exposed controls using polymerase chain reaction-restriction fragment-length polymorphism analysis. All investigated polymorphisms were equally distributed between two groups of CLL patients and IR-exposed controls, except that that there was a significant reduction of the common homozygous Lys/Lys XPD genotype among IR-exposed CLL patients (23.7%) compared with IR-exposed controls (45.6%), OR = 0.37; 95% CI = 0.18-0.75; (P = 0.005). The number of IR-non-exposed CLL patients (37.4%) with the Lys/Lys XPD genotype was also decreased compared to IR-exposed controls, although this difference was not significant (P = 0.223). These preliminary data suggest a possible modifying role of Lys751Gln XPD polymorphism for the development of CLL, expecially in radiation-exposed persons.
Research Center for Radiation Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
Iryna
I
Abramenko
Nadiia
N
Bilous
Anatolyi
A
Chumak
Alexey
A
Kostin
Zoya
Z
Martina
Iryna
I
Dyagil
D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology / Q000235:genetics* / Q000266:history; D007953:Leukemia, Radiation-Induced / Q000209:etiology / Q000235:genetics* / Q000266:history; D008297:Male; D008875:Middle Aged; D055848:Nuclear Power Plants / Q000266:history; D011110:Polymorphism, Genetic; D014455:Ukraine; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics
D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human