Placental expression of indoleamine 2,3-dioxygenase.
This review focuses on the placental expression of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase-1 (IDO1) and its potential roles, which may not only encompass immunosuppression and antimicrobial activity, but also vasodilation based on the endothelial expression on both sides of the feto-maternal interface.
Center for Molecular Medicine, Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria. peter.sedlmayr@medunigraz.at
Peter
P
Sedlmayr
Astrid
A
Blaschitz
D001424:Bacterial Infections / Q000276:immunology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D005865:Gestational Age; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000502:physiology*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology; D010920:Placenta / Q000098:blood supply / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase