6-hydroxy-L-nicotine from Arthrobacter nicotinovorans sustain spatial memory formation by decreasing brain oxidative stress in rats.
Male Wistar rats were subjected to chronic 6-hydroxy-L-nicotine treatment (6HLN, 0.3 mg/kg, i.p., seven consecutive days) and their memory performance was studied by means of Y-maze and radial arm-maze tasks. 6HLN significantly increased spontaneous alternations in Y-maze task and working memory in radial arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial arm-maze task. In addition, 6HLN increased antioxidant enzymes activity and decreased production of lipid peroxidation, suggesting antioxidant effects. Also, the linear regression between behavioral measures and oxidative stress markers resulted in significant correlations. Therefore, positive effects of 6HLN on spatial memory may occur by antioxidant actions.
Department of Biology, Alexandru Ioan Cuza University, Boulevardul Carol I No. 11, Iasi, Romania. hritcu@uaic.ro
Lucian
L
Hritcu
Marius
M
Stefan
Roderich
R
Brandsch
Marius
M
Mihasan
D000818:Animals; D001173:Arthrobacter / Q000737:chemistry*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D009538:Nicotine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
C502317:6-hydroxynicotine; D008315:Malondialdehyde; D009538:Nicotine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase