Knowledge translation: airway epithelial cell migration and respiratory diseases.
Airway epithelial cell migration is essential for lung development and growth, as well as the maintenance of respiratory tissue integrity. This vital cellular process is also important for the repair and regeneration of damaged airway epithelium. More importantly, several lung diseases characterized by aberrant tissue remodeling result from the improper repair of damaged respiratory tissue. Epithelial cell migration relies upon extracellular matrix molecules and is further regulated by numerous local, neuronal, and hormonal factors. Under inflammatory conditions, cell migration can also be stimulated by certain cytokines and chemokines. Many well-known environmental factors involved in the pathogenesis of chronic lung diseases (e.g., cigarette smoking, air pollution, alcohol intake, inflammation, viral and bacterial infections) can inhibit airway epithelial cell migration. Further investigation of cellular and molecular mechanisms of cell migration with advanced techniques may provide knowledge that is relevant to physiological and pathological conditions. These studies may eventually lead to the development of therapeutic interventions to improve lung repair and regeneration and to prevent aberrant remodeling in the lung.
Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.
Helan
H
Xiao
Debbie X
DX
Li
Mingyao
M
Liu
D056151:Airway Remodeling; D000428:Alcohol Drinking / Q000009:adverse effects; D002465:Cell Movement; D003550:Cystic Fibrosis / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology / Q000502:physiology; D006801:Humans; D008168:Lung / Q000166:cytology / Q000503:physiopathology; D012038:Regeneration; D020545:Respiratory Mucosa / Q000166:cytology / Q000503:physiopathology*; D012140:Respiratory Tract Diseases / Q000473:pathology / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects