Fundus autofluorescence findings of choroidal osteoma.
OBJECTIVE
To describe fundus autofluorescence (FAF) characteristics associated with choroidal osteomas and their secondary complications.


METHODS
Retrospective descriptive case series of six eyes of five patients with choroidal osteomas. Findings of FAF correlated with visual acuity, clinical features, lesion characteristics, and findings from other imaging modalities.


RESULTS
All 6 choroidal osteomas (100%) had totally or partially calcified, orange portions that were isoautofluorescent. Partial decalcification also produced areas of hyperautofluorescence and granular hypoautofluorescence corresponding to overlying retinal pigment epithelium mottling in 3 eyes (50%). Total decalcification with retinal pigment epithelial atrophy produced decreased FAF in 2 eyes (33%). Serous retinal detachment was present in 3 eyes (50%). When the overlying retinal pigment epithelium was viable, hyperautofluorescence as a result of elongation of the outer segments of photoreceptor was observed. In one eye where geographic atrophy of the retinal pigment epithelium was present, FAF was decreased even in the presence of serous retinal detachment. Portions of three partially or totally decalcified osteomas within the treatment field of photodynamic therapy for choroidal neovascularization were hypoautofluorescent. Four eyes (67%) had reduced foveal FAF and visual acuity <20/20, while both eyes with foveal isoautofluorescence had normal (20/20) visual acuity.


CONCLUSIONS
Calcified portions of choroidal osteomas not previously treated with photodynamic therapy were isoautofluorescent. Decalcification and secondary complications of serous retinal detachment, choroidal neovascularization, and geographic atrophy altered foveal autofluorescence and were associated with reduced visual acuity.
Cincinnati Eye Institute, Cincinnati, Ohio 45242, USA. rsisk@cincinnatieye.com
Robert A
RA
Sisk
Christopher D
CD
Riemann
Michael R
MR
Petersen
Robert E
RE
Foster
Daniel M
DM
Miller
Timothy G
TG
Murray
James J
JJ
Augsburger
D000293:Adolescent; D000328:Adult; D002114:Calcinosis / Q000175:diagnosis*; D002648:Child; D002830:Choroid Neoplasms / Q000175:diagnosis*; D020256:Choroidal Neovascularization / Q000175:diagnosis; D005260:Female; D005451:Fluorescein Angiography; D057092:Geographic Atrophy / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010016:Osteoma / Q000175:diagnosis*; D012163:Retinal Detachment / Q000175:diagnosis; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology