[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].
Activating mutation in K-ras gene is a key event in the pathogenesis of colon carcinoma. This study analyses frequency of this mutation in different age groups of colorectal cancer patients residing in North-Western Russia, and examines its relationship with essential clinical characteristics of tumor disease.
A V
AV
Beliaeva
G A
GA
Ianus
E N
EN
Suspithyn
O A
OA
Zaĭtseva
O S
OS
Iatsuk
A B
AB
Moiseenko
A V
AV
Guliaev
E N
EN
Imianitov
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000473:pathology; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D059645:Mutation Rate; D016133:Polymerase Chain Reaction; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D012426:Russia