Postoperative global amnesia reversed with flumazenil.
Global postoperative amnesia (profound anterograde and retrograde amnesia) is rare and usually attributed to transient global amnesia-a poorly understood condition with no broadly accepted mechanism. We report an incident of probable transient global amnesia in a patient after endoscopic retrograde cholangiopancreatogram under general anesthesia, which was successfully treated with flumazenil. On the basis of the results of flumazenil administration in this and a previous case report, we would recommend a trial dose of 0.2 mg for cases of global postoperative amnesia, repeated if the first dose seems effective.
Department of Anesthesiology and Perioperative Care, University of California, Orange, CA 92868, USA. jrinehar@uci.edu
Joseph B
JB
Rinehart
Brandee
B
Baker
Darren
D
Raphael
D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology*; D000700:Analgesics / Q000008:administration & dosage; D000768:Anesthesia, General / Q000009:adverse effects*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D000077335:Desflurane; D003924:Diabetes Mellitus, Type 2; D005283:Fentanyl / Q000008:administration & dosage; D005442:Flumazenil / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives; D008297:Male; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D010195:Pancreatitis / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy*; D015742:Propofol / Q000008:administration & dosage
D000700:Analgesics; D018757:GABA Modulators; D005442:Flumazenil; D000077335:Desflurane; D007530:Isoflurane; D004091:Hydromorphone; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol