Addenbrooke's Cognitive Examination-Revised for mild cognitive impairment in Parkinson's disease.
BACKGROUND
Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed.


METHODS
We investigated the utility of the Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment (MCI) in PD in an incident population-representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219).


RESULTS
Twenty-two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory-Revised and Parkinson's Disease Questionnaire 39.


CONCLUSIONS
This instrument is a useful screening tool for PD-MCI, and poor performance is significantly related to impaired behavior and quality of life.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. pmccolgan02@qub.ac.uk
Peter
P
McColgan
Jonathan R
JR
Evans
David P
DP
Breen
Sarah L
SL
Mason
Roger A
RA
Barker
Caroline H
CH
Williams-Gray
D000368:Aged; D001519:Behavior; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology / Q000523:psychology*; D015331:Cohort Studies; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D011788:Quality of Life; D012372:ROC Curve; D015203:Reproducibility of Results