Steroid receptor coupling becomes nuclear.
In this issue of Chemistry & Biology, Grossman et al. report a study on aldosterone-dependent nuclear translocation of the mineralocorticoid receptor (MR). They analyze the dependency of MR retrotransport, DNA-binding, and transcriptional activity on Hsp90 and demonstrate that MR dimerization is a nuclear event.
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires/INQUIBICEN and IBYME/CONICET, Buenos Aires C1428ADN, Argentina. mgali@qb.fcen.uba.ar
Mario D
MD
Galigniana