Etiology and clinical outcome of non-resolving pneumonia in a tertiary care centre.
BACKGROUND
A patient diagnosed to have pneumonia and put on empirical antibiotics but did not show the expected resolution is a common problem faced by the clinician.


OBJECTIVE
(1) To find out the etiology and clinical outcome of nonresolving pneumonia in a tertiary care centre, (2) To find out the co-morbid conditions associated with nonresolution.


METHODS
70 patients who did not show expected resolution after two weeks of adequate antibiotics were investigated systematically to find out the possible cause for non resolution and the associated co-morbid conditions.


RESULTS
Tuberculosis was the commonest cause of nonresolving pneumonia (35.7%), followed by malignancy (27.1%), Bronchiectasis (8.6%), Pneumocystis pneumonia (7.1%),BOOP (5.7%) and Resistance to antibiotics (14.3%). Co-morbidities like COPD, diabetes, alcoholism, smoking and immunosuppression are significant factors causing nonresolution.


CONCLUSIONS
This study stresses the need for a systematic approach to find out the etiology and properly manage nonresolving pneumonias.
Department of Pulmonary Medicine, Medical College, Thiruvananthapuram, Kerala.
B
B
Jayaprakash
Vipin
V
Varkey
K
K
Anithakumari
D000328:Adult; D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015897:Comorbidity; D003937:Diagnosis, Differential; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D011446:Prospective Studies; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
D000900:Anti-Bacterial Agents