Dyskeratosis congenita with malignant transformation.
Dyskeratosis congenita (DC) is a rare genodermatosis characterised by a classic triad of dystrophic nails, reticular skin pigmentation and mucous membrane leukoplakic patches, which have a high rate of malignant transformation. The case report presented here deals with a sporadic case of DC without similar clinical presentation in the first-degree and second-degree relatives. Of note in this case, there was rapid malignant transformation in the non-homogeneous nodulo-speckled leukoplakic patch on the dorsum of the tongue.
Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College & Hospital, Kolkata, India. jaygopalray@yahoo.co.in
Jay Gopal
JG
Ray
Niharika
N
Swain
Ranjan
R
Ghosh
Richa
Swetag
S
Pattanayak Mohanty
D000328:Adult; D002471:Cell Transformation, Neoplastic; D019871:Dyskeratosis Congenita / Q000473:pathology*; D006801:Humans; D008297:Male; D014062:Tongue Neoplasms / Q000473:pathology*