Rhabdomyolysis as a potential complication of carbamazepine-induced toxic epidermal necrolysis.
Toxic epidermal necrolysis (TEN) is a rare and severe exfoliative skin disorder characterized as widespread epidermis destruction and is usually a drug-induced condition. TEN has a high mortality rate, and multisystemic involvement is very frequent. Gastrointestinal, respiratory, hepatic, pancreatic, ocular, and hematological disturbances are common complications of TEN. Here, we report on a 30-year-old male with TEN who developed concurrent rhabdomyolysis. The exact relationship between TEN and rhabdomyolysis remains unknown. Because of lack of underlying etiology, we hypothesized that rhabdomyolysis is a potential TEN-related complication.
Department of Critical Care Medicine, Armed Forces Taoyuan General Hospital, Taoyuan, Taiwan.
Li-Yen
LY
Huang
Chih-Ming
CM
Lin
Chien-Chun
CC
Chiou
Wei-Shiang
WS
Lin
Shu-Meng
SM
Cheng
D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000175:diagnosis* / Q000209:etiology; D012559:Schizophrenia / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis*
D018692:Antimanic Agents; D002220:Carbamazepine