Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.
An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.
Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, USA.
Shaolin
S
Zhu
David W C
DW
MacMillan
D000470:Alkaloids / Q000138:chemical synthesis*; D001555:Benzene Derivatives / Q000138:chemical synthesis; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis*; D009861:Onium Compounds / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis*
D000470:Alkaloids; D001555:Benzene Derivatives; D007211:Indoles; D009861:Onium Compounds; D011758:Pyrroles; C057812:indoline; D003300:Copper