Causative Drugs and Clinical Outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN Overlap in Children.
BACKGROUND
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe adverse drug reactions in children.


OBJECTIVE
The objective was to study the causative drugs and outcome in children with SJS, SJS-TEN overlap, and TEN.


METHODS
Retrospective analysis of all the in-patient records of children below 18 years of age with the diagnosis of SJS, SJS-TEN overlap, and TEN was carried out.


CONCLUSIONS
Twenty children were identified, eight patients each were diagnosed as SJS and TEN and four as SJS-TEN overlap. Multiple drugs were implicated in 15 cases while single drug was responsible in 5 cases. Antibiotics (40.7%) were implicated as the commonest cause followed by NSAIDS (25.9%) and anticonvulsants (7.4%). Seventeen patients recovered completely and three patients died.
Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Gomathy
G
Sethuraman
Vinod K
VK
Sharma
Pooja
P
Pahwa
Pooja
P
Khetan