[Myocardial injury and inflammatory response after interventional therapy in children with congenital heart disease].
OBJECTIVE
To study myocardial injury and inflammatory response within 7 days after interventional therapy in children with congenital heart disease (CHD).


METHODS
A total of 77 children with CHD, including 12 cases of ventricular septal defect (VSD), 14 cases of atrial septal defect (ASD), 14 cases of pulmonary stenosis (PS) and 37 cases of patent ductus arteriosus (PDA), were enrolled. The levels of myocardial enzyme (AST, CK and CKMB), cardiac troponin I (cTnI) and CRP in serum were measured before operation, immediately after operation, and 6 hrs, 24 hrs, 72 hrs and 7 days after operation.


RESULTS
Serum AST levels in the VSD group were significantly higher than the other CHD groups immediately after operation, and 6 hrs and 24 hrs after operation (P<0.05). There were significant differences in serum CK and CKMB levels among the four CHD groups immediately and 6 hrs after operation (P<0.05), and the highest serum CK and CKMB levels were found in the VSD group. Serum CRP levels in the PDA group were significantly higher than the other CHD groups 72 hrs and 7 days after operation (P<0.05). Compared with before operation, serum AST levels increased significantly in all four CHD groups 6 and 24 hrs after operation groups (P<0.05). Serum CK and CKMB levels increased significantly in the VSD group immediately and 6 hrs after operation (P<0.05). Serum cTnI levels increased significantly in the VSD, PDA and PS groups immediately and 6 hrs after operation (P<0.05). The PDA group showed increased CRP levels 24 hrs, 72 hrs and 7 days after operation (P<0.05).


CONCLUSIONS
Minor myocardial injury can be noted within 7 days after interventional therapy in children with CHD and mainly occurs between immediately and 24 hrs after operation. The injury is more significant in VSD cases. The interventional therapy does not cause significant inflammation.
Department of Cardiology, Anhui Provincial Children's Hospital, Hefei 230051, China. jiangrong_6@163.com
Rong
R
Jiang
Sheng
S
Zhao
Mei
M
Li
Feng
F
Liu
Lin
L
Li
Gui-Ming
GM
Yang
Ze-Long
ZL
Wang
Dong
D
Yu
Li-Hua
LH
Huang
Xiao-Bi
XB
Huang
D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006330:Heart Defects, Congenital / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000209:etiology; D008297:Male; D009206:Myocardium / Q000473:pathology; D019210:Troponin I / Q000097:blood
D019210:Troponin I; D002097:C-Reactive Protein; D052279:Creatine Kinase, MB Form