Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Four hinge-binding scaffolds have been explored for novel selective Aurora kinase inhibitors. The structure activity relationship, selectivity and pharmacokinetic profiles have been evaluated.
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA. zhiqin.ji@abbott.com
Zhiqin
Z
Ji
Yujia
Y
Dai
Cele
C
Abad-Zapatero
Daniel H
DH
Albert
Jennifer J
JJ
Bouska
Keith B
KB
Glaser
Patrick A
PA
Marcotte
Nirupama B
NB
Soni
Terry J
TJ
Magoc
Kent D
KD
Stewart
Ru-Qi
RQ
Wei
Steve K
SK
Davidsen
Michael R
MR
Michaelides
D000818:Animals; D064127:Aurora Kinases; D002460:Cell Line; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases