Characterization of an unusual ring-contraction degradant of the antifungal agent posaconazole.
Posaconazole, a clinically useful antifungal agent, has several known oxidative degradation products involving the piperazine ring near the center of the molecule. A novel degradant was recently isolated and characterized spectroscopically as a novel ring-contraction product incorporating a dihydroimidazolium moiety in lieu of the normally present piperazine ring.
Wenqing
W
Feng
Bruce D
BD
Hilton
Wendy
W
Zhong
Jiong
J
Yang
Xi
X
Yang
Weidong
W
Tong
Gary E
GE
Martin
D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D014230:Triazoles / Q000737:chemistry* / Q000378:metabolism
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole