Field outbreak strains of serotype O foot-and-mouth disease virus from India with a deletion in the immunodominant βG-βH loop of the VP1 protein.
Foot-and-mouth disease virus serotype O accounts for around 80 % of the outbreaks in India. Although Indian serotype O isolates belongs to the ME-SA topotype, circulation of different lineages has been noted. After its emergence in the year 2001, the 'Ind2001' lineage outcompeted the PanAsia lineage in causing serotype O outbreaks in the year 2009. Three isolates had an amino acid deletion at position 139 in the VP1 coding region and grouped with the 'Ind2001' lineage. The currently used Indian vaccine strain of serotype O covers all of the field isolates antigenically.
Project Directorate on Foot-and-Mouth Disease, Mukteswar-Kumaon, Nainital, Uttarakhand, India.
Biswajit
B
Das
Aniket
A
Sanyal
Saravanan
S
Subramaniam
Jajati K
JK
Mohapatra
Bramhadev
B
Pattnaik
D000818:Animals; D036022:Capsid Proteins / Q000235:genetics* / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary*; D005536:Foot-and-Mouth Disease / Q000453:epidemiology* / Q000821:virology; D029544:Foot-and-Mouth Disease Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D016056:Immunodominant Epitopes / Q000235:genetics; D007194:India / Q000453:epidemiology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D012703:Serotyping
D036022:Capsid Proteins; D016056:Immunodominant Epitopes; C442501:VP1 protein, Foot-and-mouth disease virus