Living with disability: patterns of health problems and symptom mediation of health consequences.
BACKGROUND
People with disability experience a range of symptoms that may serve as an important linkage between disability and other health consequences. The aims of this study were to describe and compare symptom experiences of people with and without disability using a population-based sample and to test direct relationships between disability and health status and indirect effects of disability mediated through symptom experience.


METHODS
A Midwestern sample of 12,249 adults aged 40 and older responded to a cross-sectional survey. Data collected included symptom prevalence and frequencies for 21 commonly reported symptoms, self-perceived health status and physical functioning, number of medications, and demographic variables. Two mediation analyses were conducted using cumulative symptom frequency as the mediator between disability status and both self-rated health and physical functioning.


RESULTS
Adults with disability reported significantly greater prevalence and frequencies for all 21 symptoms, with pain and fatigue being the most common. The indirect effect through cumulative symptom frequency explained roughly half of the total effect of disability on general health status, and about one third of the total effect of disability on physical functioning.


CONCLUSIONS
This study found evidence supporting the diverse and significant symptom experience of people living with disability, especially for symptoms of pain and fatigue. Moreover, symptom experience was found to partially mediate the effects of disability on self-reported general health status and physical functioning. This provides support for symptoms serving as an important link to health outcomes in patients with disability.
Department of Pharmacy Practice and Science, University of Iowa College of Pharmacy, Iowa City, IA 52242, USA. brandonjpatterson@gmail.com
Brandon J
BJ
Patterson
William R
WR
Doucette
Scott D
SD
Lindgren
Elizabeth A
EA
Chrischilles
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D059026:Diagnostic Self Evaluation; D006233:Persons with Disabilities; D005221:Fatigue / Q000453:epidemiology*; D005260:Female; D006262:Health; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D015146:Midwestern United States / Q000453:epidemiology; D010146:Pain / Q000453:epidemiology*; D010465:Perception; D004364:Pharmaceutical Preparations; D015995:Prevalence; D057566:Self Report
D004364:Pharmaceutical Preparations