Steric-electronic effects in malarial peptides inducing sterile immunity.
Conserved Plasmodium falciparum high activity binding peptides' (HABPs) most relevant proteins involved in malaria parasite invasion are immunologically silent; critical binding residues must therefore be specifically replaced to render them highly immunogenic and protection-inducing. Such changes have a tremendous impact on these peptides' steric-electronic effects, such as modifications to peptide length peptide bonds and electronic orbitals' disposition, to allow a better fit into immune system MHCII molecules and better interaction with the TCR which might account for the final immunological outcome.
Fundación Instituto de Inmunología de Colombia, Bogotá, Colombia.
Armando
A
Moreno-Vranich
Manuel E
ME
Patarroyo
D000818:Animals; D001029:Aotus trivirgatus; D004583:Electrons; D007107:Immune System / Q000276:immunology; D007109:Immunity; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
D010455:Peptides; D011948:Receptors, Antigen, T-Cell