Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.
Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 μmol/kg/min; P < .05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Anne
A
Vrieze
Els
E
Van Nood
Frits
F
Holleman
Jarkko
J
Salojärvi
Ruud S
RS
Kootte
Joep F W M
JF
Bartelsman
Geesje M
GM
Dallinga-Thie
Mariette T
MT
Ackermans
Mireille J
MJ
Serlie
Raish
R
Oozeer
Muriel
M
Derrien
Anne
A
Druesne
Johan E T
JE
Van Hylckama Vlieg
Vincent W
VW
Bloks
Albert K
AK
Groen
Hans G H J
HG
Heilig
Erwin G
EG
Zoetendal
Erik S
ES
Stroes
Willem M
WM
de Vos
Joost B L
JB
Hoekstra
Max
M
Nieuwdorp
D000328:Adult; D042481:Alcaligenes faecalis; D041963:Bacteroidetes; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003013:Clostridium; D004926:Escherichia coli; D005051:Eubacterium; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D006801:Humans; D007333:Insulin Resistance; D007421:Intestine, Small / Q000382:microbiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000628:therapy*; D054892:Metagenome; D008875:Middle Aged; D020624:Oxalobacter formigenes; D018709:Statistics, Nonparametric
D001786:Blood Glucose; D005232:Fatty Acids, Volatile