Roller compaction: application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics.
This paper reports the use of an in-gap ribbon porosity calculation for the optimisation of roller compaction ribbon parameters in order to control downstream granule and tablet properties for a typical pharmaceutical formulation. The study demonstrates the effect of changes to roll speed and roll gap on the relative level of ribbon compaction for ribbons with equivalent in-gap porosities. It is demonstrated that in-gap ribbon porosity can be applied to enable optimization of the downstream granule processability characteristics for a typical pharmaceutical formulation and an understanding of the control space of a roller compaction process.
Biopharmaceutics R&D, Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral, England. john.gamble@bms.com
John F
JF
Gamble
Michael
M
Tobyn
Andrew B
AB
Dennis
Trupty
T
Shah
D000578:Amidines / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D010316:Particle Size; D016062:Porosity; D011720:Pyrazoles / Q000737:chemistry*; D013607:Tablets
D000578:Amidines; D011720:Pyrazoles; D013607:Tablets; C569626:ibipinabant