DoReMi stem cells and DNA damage workshop. Introduction.
OBJECTIVE
The target cells for radiation carcinogenesis are widely held to be stem or stem-like cells. Classically, stem cells are considered to be those capable of renewing tissues while differentiated cells lose the potential to replicate. More recently it has become apparent that greater developmental plasticity exists and that cells can be reprogrammed to form induced pluripotent stem cells. Modelling of radiation cancer-risk requires understanding of the characteristics, numbers and responses of target stem cells to radiation. Therefore progress in understanding mechanisms of radiation-induced carcinogenesis is dependent on knowledge of stem cell radiobiology.


RESULTS
In this context, the European Community's network of excellence on low dose radiation risk called, 'Low Dose Research towards Multidisciplinary Integration (DoReMi)' ( www.doremi-noe.net ) and the United Kingdom's Health Protection Agency organised a workshop on Stem Cells and DNA damage in Oxfordshire on 7/8 December 2011 to address issues relating to radiation, DNA damage and stem cells. In keeping with the aim of improving understanding of low dose ionising radiation health risk, a panel of experts in stem cells and radiobiology were invited to this workshop. This summary includes all presentations at this workshop and is accompanied by full reports of several speakers.
Biological Effects Department, Health Protection Agency, Didcot, Oxfordshire, UK. Ken.raj@hpa.org.uk
Kenneth
K
Raj
Simon
S
Bouffler
D000818:Animals; D002460:Cell Line; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012306:Risk; D055153:Stem Cell Niche / Q000528:radiation effects; D013234:Stem Cells / Q000378:metabolism / Q000528:radiation effects*
D017382:Reactive Oxygen Species; D046988:Proteasome Endopeptidase Complex