A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core.
A synthesis of the core ring structure of the fargenin/fargenone family of natural products is presented. The general strategy is based upon biosynthetic speculation and exploits a cascade reaction, which transforms a spirocyclic dienone into the core ring system via a deprotonation-oxy-Michael-Wittig olefination sequence. This study represents the first synthesis work towards this family of natural products.
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. ross.denton@nottingham.ac.uk
Ross M
RM
Denton
James T
JT
Scragg
D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis*; D029523:Illicium / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D001688:Biological Products; D017705:Lignans; C007633:estragole