Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment.
OBJECTIVE
Rhegmatogenous retinal detachment (RRD) affects the function of the retina before and after surgical repair. We investigated ultra-wide-field autofluorescence (UAF) abnormalities in patients with acute RRD to improve our understanding of the functional changes in the retina before and after surgery.


METHODS
In this retrospective study, we present the UAF imaging findings of 16 patients with acute, non-traumatic RRD. Imaging was obtained with the Optos 200 Tx (Optos) in 14 eyes preoperatively and in 12 eyes postoperatively. Twelve eyes had RRDs that involved the macula (group A), whereas four eyes had macula-sparing RRDs (group B).


RESULTS
All patients (100%) with bullous retinal detachments demonstrated hypofluorescence over the area of retinal detachment. A hyperfluorescent leading edge (HLE) to the retinal detachment was observed preoperatively in 100% of eyes in group A and 75% of eyes in group B. Preoperative UAF through the fovea of group A eyes was normal (30%), hypofluorescent (50%) or hyperfluorescent (20%). In all patients with a HLE preoperatively, the HLE resolved by the 1-month postoperative visit. A residual line of demarcation remained in 8 of the 12 eyes (67%). In group A eyes, postoperative granular autofluorescent changes were present in four of the nine (44%) eyes, and were associated with worse preoperative (P=0.04) and postoperative (P=0.09) visual acuity.


CONCLUSIONS
UAF imaging reveals abnormalities in RRDs that allow excellent demarcation of the extent of the retinal detachment and assist in preoperative characterization of the detachment and postoperative counselling.
Department of Ophthalmology, Weill Cornell Medical College, New York, NY 10021, USA. maw2052@med.cornell.edu
M T
MT
Witmer
M
M
Cho
G
G
Favarone
R V Paul
RV
Chan
D J
DJ
D'Amico
S
S
Kiss
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058450:Endotamponade; D005131:Eye Injuries / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005451:Fluorescein Angiography; D005466:Fluorocarbons / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000293:injuries; D012163:Retinal Detachment / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D012591:Scleral Buckling; D014821:Vitrectomy
D005466:Fluorocarbons; C042852:perflutren