Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array.
Photoacoustics has recently been proposed as a potential method to guide and/or monitor therapy based on high-intensity focused ultrasound (HIFU). We experimentally demonstrate the creation of a HIFU lesion at the location of an optical absorber, by use of photoacoustic signals emitted by the absorber detected on a dual mode transducer array. To do so, a dedicated ultrasound array intended to both detect photoacoustic waves and emit HIFU with the same elements was used. Such a dual-mode array provides automatically coregistered reference frames for photoacoustic detection and HIFU emission, a highly desired feature for methods involving guidance or monitoring of HIFU by use of photoacoustics. The prototype is first characterized in terms of both photoacoustic and HIFU performances. The probe is then used to perform an idealized scenario of photoacoustic-guided therapy, where photoacoustic signals generated by an absorbing thread embedded in a piece of chicken breast are used to automatically refocus a HIFU beam with a time-reversal mirror and necrose the tissue at the location of the absorber.
Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM ERL U979, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Amaury
A
Prost
Arik
A
Funke
Mickaël
M
Tanter
Jean-François
JF
Aubry
Emmanuel
E
Bossy
D000042:Absorption; D000162:Acoustics; D000818:Animals; D002645:Chickens; D003952:Diagnostic Imaging / Q000379:methods; D004581:Electronics; D004867:Equipment Design; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D008027:Light; D055095:Optics and Photonics; D009991:Oscillometry / Q000379:methods; D061088:Photoacoustic Techniques / Q000379:methods*; D011312:Pressure; D013696:Temperature; D014159:Transducers; D014464:Ultrasonic Therapy / Q000379:methods*