Spatial regulation of BMP activity.
The bone morphogenetic protein (BMP) signalling pathway is critical for embryonic development and tissue homeostasis, and impaired BMP signalling has been implicated in multiple diseases. Molecular tools have been developed to visualise BMP activity in vivo and these have allowed a better understanding of the intricate ways in which BMP activity is regulated spatially. In particular, generation and interpretation of BMP activity gradients during development result from the complex interplay between core BMP signalling components and specific regulators. In this essay we discuss the mechanisms by which spatial regulation of BMP activity is achieved and its functional consequences.
Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, United Kingdom.
Marie-Christine
MC
Ramel
Caroline S
CS
Hill
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D015509:Developmental Biology / Q000379:methods; D004331:Drosophila melanogaster / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D010766:Phosphorylation; D011485:Protein Binding; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014982:Xenopus laevis / Q000378:metabolism; D015027:Zebrafish
D019485:Bone Morphogenetic Proteins; D008024:Ligands; D016212:Transforming Growth Factor beta