Association of serum ferritin with coronary artery disease.
BACKGROUND
Published results regarding the association of serum ferritin with coronary artery disease (CAD) were conflicting, thus a case-control study and a meta-analysis were performed to assess the association between serum ferritin and CAD risk.


METHODS
A hospital-based case-control study was conducted with 258 CAD cases and 282 healthy controls. The restricted cubic spline (RCS) function with three knots was used to assess the concentration-risk association between serum ferritin and CAD risk. A meta-analysis was performed including 20 outcomes. Fixed or random effect pooled measure was selected on the basis of homogeneity test among studies.


RESULTS
In our case-control study, compared with serum ferritin concentrations less than 200 μg/L as the reference, the trend of CAD risk increased by 4.2% for every 50 μg/L increase in serum ferritin (OR=1.042, 95% CI=0.946-1.147). In the meta-analysis and after excluding articles that were the key contributors to between-study heterogeneity, the standardized mean difference (SMD) of serum ferritin was associated with increased CAD risk (FEM: SMD=0.119, 95% CI=0.073-0.165). And the concentration-risk meta-analysis suggested that, for every 50 μg/L increase of serum ferritin, the risk of CAD increases by 2.4% (OR=1.024, 95% CI=1.001-1.048).


CONCLUSIONS
These findings indicate that serum ferritin is weakly positively associated with CAD risk. This risk needs to be confirmed by further studies.
Department of Epidemiology and Health Statistics, Shandong University, PR China.
Yunping
Y
Zhou
Tongtao
T
Liu
Changwei
C
Tian
Peipei
P
Kang
Chongqi
C
Jia
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
D005293:Ferritins