Churg-Strauss syndrome presenting with acute renal insufficiency accompanied by eosinophilic tubulointerstitial nephritis.
We encountered an unusual and rare case of 59-year-old woman with Churg-Strauss syndrome (CSS) showing myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-related acute renal insufficiency accompanied by eosinophilic tubulointerstitial nephritis. To date, reports in English of CSS presenting with rapidly progressive/acute renal insufficiency and biopsy-proven renal lesions have been uncommon. Here, we discuss this unusual case and review the previously reported CSS cases. The complication of eosinophilic tubulointerstitial nephritis in CSS cases with acute renal insufficiency might be higher than generally thought. Furthermore, the presence of eosinophilic infiltration and eosinophilic tubulointerstitial nephritis might be associated with the good renal outcome in CSS patients.
Nephrology Center, Toranomon Hospital, Japan. hirohama-tky@umin.ac.jp
Daigoro
D
Hirohama
Junichi
J
Hoshino
Keiichi
K
Sumida
Eiko
E
Hasegawa
Rikako
R
Hiramatsu
Masayuki
M
Yamanouchi
Noriko
N
Hayami
Tatsuya
T
Suwabe
Naoki
N
Sawa
Fumi
F
Takemoto
Yoshifumi
Y
Ubara
Shigeko
S
Hara
Kenichi
K
Ohashi
Kenmei
K
Takaichi
D058186:Acute Kidney Injury / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D004802:Eosinophilia / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009195:Peroxidase / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D009195:Peroxidase