Atrial fibrillation, blood loss, and transfusion in patients with left ventricular dysfunction:  what is the effect of cardiopulmonary bypass?
Despite advancements in surgical technique, intensive care methods and pharmaceutical prophylaxis atrial fibrillation (AF) after on-pump coronary artery bypass remains common. Transfusion, blood loss, and cardiopulmonary bypass (CPB) have been identified as risk factors for AF and adverse outcomes such as early mortality. This study examines outcomes in patients with left ventricular dysfunction after revascularization with and without CPB. A systematic literature review identified 22 studies including 7,454 patients. Meta-analysis through subgroup analysis of the highest-quality studies revealed that the off-pump coronary artery bypass (OPCAB) technique is associated with a significantly lower incidence of blood loss, transfusion requirement, reoperation for bleeding, and length of stay. There was also a reduction in the incidence of AF in the OPCAB group but this was not statistically significant (odds ratio = 0.77, 95% confidence interval 0.58-1.02, p = 0.07). The results strengthen research suggesting that CPB has a damaging effect on hemostasis and subsequent transfusion requirements in this patient group. More research is required to assess the association between OPCAB and AF in patients with ventricular dysfunction.
Department of Surgery and Cancer, Imperial College London, United Kingdom. omarjarral@gmail.com
Omar A
OA
Jarral
Srdjan
S
Saso
Leanne
L
Harling
Roberto
R
Casula
Thanos
T
Athanasiou
D001281:Atrial Fibrillation / Q000150:complications* / Q000628:therapy; D001803:Blood Transfusion; D002309:Cardiology / Q000379:methods; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects / Q000379:methods; D005260:Female; D006470:Hemorrhage; D006487:Hemostasis; D006801:Humans; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000628:therapy*