[Serum sCD44v6 and sE-cadherin levels in patients with esophageal squamous cell carcinoma].
To investigate the serum levels of sCD44v6 and sE-cadherin (sE-cad) in patients with esophageal squamous cell carcinoma.



The serum samples were collected from 65 cases of esophageal squamous cell carcinoma, 32 cases of erosive esophagitis and 35 healthy subjects. Serum sCD44v6 and sE-cad levels were measured by enzyme linked immunosorbent assay (ELISA).



The mean levels of serum sCD44v6 and sE-cad in esophageal squamous cell carcinoma patients were significantly higher than those of erosive esophagitis patients and normal controls (both P<0.05). There was no significant difference in serum sCD44v6 and sE-cad levels between erosive esophagitis patients normal controls (P=0.566 and P=0.708, respectively). Serum sCD44v6 and sE-cad levels of esophageal cancer patients were not correlated with their clinicopathological features. Serum sCD44v6 level is not correlated with sE-cad level in squamous cell carcinoma patients(P=0.651).



Serum sCD44v6 and sE-cad might be a potential marker for screening of esophageal squamous cell carcinoma.
Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Ying
Y
He
Jun
J
Zhang
Shu-kui
SK
Wang
Wen-bin
WB
Huang
Xin-guo
XG
Chen
Bang-shun
BS
He
You-cai
YC
Zhao
Jin-song
JS
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged
C112697:CD44v6 antigen; D015820:Cadherins; D018960:Hyaluronan Receptors