[Osteoarthritis and obesity].
Obesity is one of the risk factors for hip or knee osteoarthritis (OA), since mechanical overload on weight-bearing joints activates chondrocytes and accelerates cartilage degeneration. Surprisingly, obesity and overweight also contribute to hand OA due to a systemic effect involving the pro-inflammatory and -degenerative role of some adipokines, secreted by adipose tissue, as well as some joint cells. Obesity-induced OA is now included in a larger phenotype termed "metabolic GA", since OA is associated with various parameters of the metabolic Ssyndrome (including type-2 diabetes) and excess cardiovascular mortality related to this disease. Early-onset OA should lead to suspect a potential metabolic syndrome. Weight loss strategies remain a valuable therapeutic approach to prevent OA and reduce its symptoms, and must be associated with physical activity to allow for optimal outcomes.
Service de rhumatologie, hôpital Saint-Antoine, AP-HP, 75012 Paris. jeremie.sellam@sat.aphp.fr
Jérémie
J
Sellam
Francis
F
Berenbaum
D003131:Combined Modality Therapy; D003210:Concept Formation; D006801:Humans; D018836:Inflammation Mediators / Q000009:adverse effects / Q000378:metabolism; D008954:Models, Biological; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism / Q000628:therapy; D010003:Osteoarthritis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D013314:Stress, Mechanical; D013312:Stress, Physiological / Q000502:physiology; D061217:Weight Reduction Programs; D016474:Weight-Bearing / Q000502:physiology
D018836:Inflammation Mediators