An overview of infectious bursal disease.
Infectious bursal disease (IBD) is a viral immunosuppressive disease of chickens attacking mainly an important lymphoid organ in birds [the bursa of Fabricius (BF)]. The emergence of new variant strains of the causative agent [infectious bursal disease virus (IBDV)] has made it more urgent to develop new vaccination strategies against IBD. One of these strategies is the use of recombinant vaccines (DNA and viral-vectored vaccines). Several studies have investigated the host immune response towards IBDV. This review will present a detailed background on the disease and its causative agent, accompanied by a summary of the most recent findings regarding the host immune response to IBDV infection and the use of recombinant vaccines against IBD.
Mansoura University, Mansoura, Egypt. heba.a.mahgoub@gmail.com
Hebata Allah
HA
Mahgoub
Michael
M
Bailey
Pete
P
Kaiser
D000818:Animals; D018175:Birnaviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D002060:Bursa of Fabricius / Q000473:pathology / Q000821:virology; D002645:Chickens; D007243:Infectious bursal disease virus / Q000472:pathogenicity*; D011201:Poultry Diseases / Q000473:pathology* / Q000517:prevention & control / Q000821:virology*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
D019444:Vaccines, DNA; D014765:Viral Vaccines