First attack of Kleine-Levin syndrome triggered by influenza B mimicking influenza-associated encephalopathy.
Six days after the onset of influenza B symptoms, a 14-year-old Japanese boy presented with encephalopathy-like symptoms, somnolence, irritability, and childishness, which we first considered was an atypical type of influenza-associated encephalopathy because the infection symptoms disappeared by day 4. His encephalopathy-like symptoms gradually improved, although he had repetitive hypersomnia attacks. Owing to the patient's clinical presentation and normal interleukin-6 levels in the cerebrospinal fluid during the first period of hypersomnia, we diagnosed him with Kleine-Levin syndrome (KLS) triggered by influenza B. The preceding influenza infection was not only a diagnostic clue of KLS but also a diagnostic confounding factor.
Department of Neurology, Nagano Municipal Hospital, Japan. minori_kodaira@hospital.nagano.nagano.jp
Minori
M
Kodaira
Kanji
K
Yamamoto
D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D006801:Humans; D009981:Influenza B virus; D007251:Influenza, Human / Q000150:complications*; D017593:Kleine-Levin Syndrome / Q000175:diagnosis* / Q000209:etiology*; D008297:Male