Hypoglycemic effects of an aqueous extract of Bauhinia forficata on the salivary glands of diabetic mice.
The objective of this study was to evaluate the salivary glands in diabetic mice, analyzing alterations in the secretory epithelium and interactions with the stromal compartment acquired during a prolonged period of treatment with Bauhinia forficata extract. Female mice were divided into two groups: Nonobese diabetic (NOD) mice treated with Bauhinia forficata (I), and NOD mice not treated with the hypoglycemic agent (II). After treatment, the salivary glands were collected for analysis by transmitted and polarized light microscopy, complemented by three-dimensional analysis of these tissues. The results showed weight loss in animals of group II and weight recovery in treated animals. Glucose levels were elevated in group II, but declined in group I. In the two groups, the salivary glands were characterized by involution of the secretory epithelium, presence of an inflammatory infiltrate and an increase of extracellular fibrillar components. It can be concluded that treatment with Bauhinia forficata reduced glucose levels and contributed to weight recovery in treated animals. However, the observation of tissue destructuring and compromised epithelial-stromal interactions, with consequent impairment of glandular function, demonstrates that Bauhinia forficata exerts an effect on the recovery of body metabolism but this improvement does not influence in the tissue recovery.
Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí, FMJ, Jundiaí, São Paulo, Brazil.
Sergio Augusto Fudaba
SA
Curcio
Luciana Francine Bocchi
LF
Stefan
Bruno Azevedo
BA
Randi
Marco Antonio
MA
Dias
Rodrigo Eduardo
RE
da Silva
Eduardo José
EJ
Caldeira
D000818:Animals; D036481:Bauhinia; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D016688:Mice, Inbred NOD; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D012469:Salivary Glands / Q000187:drug effects* / Q000473:pathology; D015431:Weight Loss / Q000187:drug effects
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts