CYP2J2 -50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension.
BACKGROUND
Hypertension is a result of complex factors including multiple genetic polymorphisms.


OBJECTIVE
This study aims to check for the association of genetic polymorphisms of the cytochrome P450 2J2 (CYP 2J2) and beta-2-adrenergic receptor (ADRB2) genes with hypertension among Saudi subjects.


METHODS
This study included 116 cases with documented hypertension of at least 1 year duration. Their data were compared to that of 250 unrelated healthy nonhypertensive subjects from the same locality. For all participants, DNA was extracted and analyzed using real time polymerase chain reaction technique for the identification of genotypic and allelic variants of the CYP2J2 -50 G/T and ADRB2 G46A genes.


RESULTS
Hypertensive cases showed a significantly higher frequency of mutant CYP2J2 -50 T allele carriage (TT and GT genotypes) compared with controls (odds ratio [OR]=3.7, p=0.0003). The same was observed among subgroups of hypertension associated with diabetes and obesity (OR=3.6, p=0.007) and cases with isolated hypertension (OR=8.4, p=0.0002). On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05).


CONCLUSIONS
This study showed positive association of CYP2J2 gene polymorphism with hypertension among Saudi cases.
Molecular Biology Research Center, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Abdullah
A
Alghasham
Ahmad
A
Ali
Hisham
H
Ismail
Moataz
M
Dowaidar
Ahmad A
AA
Settin
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012529:Saudi Arabia
C553443:ADRB2 protein, human; C000717350:CYP2J2 protein, human; D018343:Receptors, Adrenergic, beta-2; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2