Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells.
A mild and versatile method for the synthesis of some novel indole-1-carbinols has been developed via one-pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO(2). The solvent-free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole-1-carbinols on cell proliferation of the hepatoma cell line FaO was evaluated.
Dipartimento Farmaco Chimico Tecnologico, Universita` degli Studi di Cagliari, Cagliari, Italy.
Gloria
G
Zedda
Gabriella
G
Simbula
Michela
M
Begala
Monica
M
Pibiri
Costantino
C
Floris
Mariano
M
Casu
Laura
L
Casu
Graziella
G
Tocco
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D049109:Cell Proliferation / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008113:Liver Neoplasms / Q000188:drug therapy; D000432:Methanol / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D000432:Methanol