Human immune responses to vaccines in the first year of life: biological, socio-economic and ethical issues - a viewpoint.
Human newborns are vulnerable to infectious diseases that account for majority of the morbidity and mortality, particularly in first year of life. Vaccines have become the most effective public health intervention strategy to curtail the prevalence of these infectious diseases. Although vaccines against a number of diseases exist, there are no vaccines against many other diseases that commonly affect children. The adequate assessment of immune responses to vaccines is an important step in the development of vaccines. However, a number of biological and "non-medical" socio-economic and ethical factors could influence either the administration and/or evaluation of vaccines in infants. Recognition and understanding of these determinants are crucial in planning interventions and for logical interpretations of results.
Vaccinology Theme, Medical Research Council MRC Unit, Banjul, Gambia. mota@mrc.gm
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D003906:Developing Countries; D005260:Female; D006801:Humans; D017589:Immunization Programs / Q000191:economics* / Q000941:ethics*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011634:Public Health; D012959:Socioeconomic Factors; D014612:Vaccines / Q000008:administration & dosage* / Q000191:economics / Q000276:immunology*
D014612:Vaccines