Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin.
Using a murine model of liver metastases, we found that oxaliplatin can enhance the immunostimulatory effect of interleukin-12 delivered by an adenoviral vector. A shift toward a favorable immune microenvironment was observed in tumors, with a relative increase in CD8+ T cells vs. T regulatory and myeloid-derived suppressor cells.
Division of Gene Therapy and Hepatology; CIMA, University of Navarra; Foundation for Applied Medical Research; Pamplona, Spain.
Ruben
R
Hernandez-Alcoceba
Pedro
P
Berraondo