Inhibitory effect of BMP-2 on the proliferation of breast cancer cells.
Bone morphogenetic proteins (BMPs) are involved in diverse biological processes,             including cell proliferation, differentiation and apoptosis. Results from the             MTT assay revealed that BMP-2 significantly inhibited the proliferation of MDA-MB‑231             and MCF-7 breast cancer cells. The flow cytometric analysis demonstrated that             BMP-2 caused G1 arrest and promoted apoptosis. An increase in p21 and cleaved             caspase-3 in the two cell lines was detected by western blot analysis, which may             be responsible for the suppression of cancer cell proliferation caused by BMP-2.             BMP-2 protected MDA-MB-231 and MCF-7 cells from generating xenograft tumors in             nude mice. Thus, BMP-2 may be considered as an inhibitor of breast cancer at the             early stages of disease.
Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, PR China.
Anan
A
Chen
Dingding
D
Wang
Xueting
X
Liu
Shuilian
S
He
Zhihong
Z
Yu
Ju
J
Wang
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology* / Q000627:therapeutic use; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000235:genetics / Q000378:metabolism; D052006:Bone Morphogenetic Protein Receptors, Type II / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D059585:G1 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D051901:Smad4 Protein / Q000235:genetics / Q000378:metabolism; D014183:Transplantation, Heterologous
D055396:Bone Morphogenetic Protein 2; D051901:Smad4 Protein; C498211:BMPR1A protein, human; C498214:BMPR1B protein, human; C498218:BMPR2 protein, human; D052005:Bone Morphogenetic Protein Receptors, Type I; D052006:Bone Morphogenetic Protein Receptors, Type II; D053148:Caspase 3