Long-term quality of life in young adults treated for oral cavity squamous cell cancer.
OBJECTIVE
We assessed the long-term quality of life (QOL) in patients who survived oral cavity squamous cell cancer when they were young and looked for any clinical factors that might adversely affect function and QOL.


METHODS
We performed a retrospective case series and questionnaire survey in a tertiary care center. The subjects were consecutive patients treated for oral cancers during a 25-year period, when they were 40 years of age or less. The patients completed the University of Washington Quality of Life questionnaire and the M. D. Anderson Dysphagia Inventory (MDADI). We made an overall descriptive report of swallowing and QOL measures in the study population and looked for any clinical factors associated with functional outcomes.


RESULTS
Among the 62 patients treated over the course of 25 years, 46 were alive and disease-free. Twenty-six participated. The median follow-up duration was 14.7 years (range, 3 to 27 years). Age at diagnosis and duration of follow-up did not correlate with overall QOL or health-related QOL. Seventy-seven percent rated their overall QOL as outstanding, very good, or good. The key domains affected by cancer were appearance, mood, saliva, and shoulder function. Radiotherapy significantly adversely affected the QOL. The median MDADI scores on all 4 subscales were at least 85%. Higher T-stage and radiotherapy were significantly associated with lower scores on all subscales.


CONCLUSIONS
The long-term health-related QOL in this cohort was quite good. Radiotherapy and tumor stage correlated with swallowing outcomes, and only radiotherapy seemed to adversely affect the overall QOL.
Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ligy
L
Thomas
Eric J
EJ
Moore
Kerry D
KD
Olsen
Jan L
JL
Kasperbauer
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D003679:Deglutition; D005260:Female; D006258:Head and Neck Neoplasms / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D011788:Quality of Life; D053484:RecQ Helicases; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D011795:Surveys and Questionnaires; D017741:Survivors; D014062:Tongue Neoplasms / Q000503:physiopathology / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome
D053484:RecQ Helicases