[Role of NO-dependent mechanisms at normal prenansy and on background of disturbance of utero placental blood circulation of white rats].
Condition of NO-dependent mechanisms, free-radical processes and calcium level in normal and on background of disturbance of uteroplacental circulation of white rats is studied. At normal pregnancy at animals activity of NO-dependent mechanisms increases, free radical processes are activated, hypocalcemia is appeared. Being injected of antagonist NO (10 mg/kg) and disturbance of uteroplacental circulation similar changes in the form of reducing of a level of nitrites, activation of free radical processes and hypercalcemia are observed. At the combined pathology synthesis of NO and nitrothyrosine increases, that in such conditions plays the protective role, providing adaptation of disturbance of uteroplacental circulation for needs of a fetus.
A S
AS
Ivanova
O G
OG
Sitnikova
S B
SB
Nazarov
D000818:Animals; D005260:Female; D006996:Hypocalcemia / Q000097:blood / Q000503:physiopathology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000097:blood; D014599:Uterus / Q000098:blood supply*
D009569:Nitric Oxide; C002744:3-nitrotyrosine; D014443:Tyrosine