Integrin triplets of marine sponges in human D2 receptor heteromers.
The evidence for the existence of receptor heteromers opens up a new field for a better understanding of neural transmission. Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several dopamine D2 receptor heteromers of human brain. The obtained results probably mean a general molecular mechanism for receptor-receptor interactions in heteromers originated from the lowest animals (marine sponges).
Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia. tar@iias.spb.su
Alexander O
AO
Tarakanov
Kjell G
KG
Fuxe
Dasiel O
DO
Borroto-Escuela
D000595:Amino Acid Sequence; D000818:Animals; D059001:Aquatic Organisms / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D016023:Integrins / Q000737:chemistry*; D008969:Molecular Sequence Data; D011161:Porifera / Q000378:metabolism*; D055503:Protein Multimerization; D017448:Receptors, Dopamine D2 / Q000737:chemistry* / Q000378:metabolism*; D016415:Sequence Alignment
D016023:Integrins; D017448:Receptors, Dopamine D2