Otoprotection in guinea pigs exposed to pesticides and ginkgo biloba.
Pesticides are widely used in agriculture, despite the risk of hearing loss related to the exposure to their chemical components. This study looks into protective drugs to counteract the ototoxicity of pesticides.


OBJECTIVE
This study aims to analyze the effect ginkgo biloba extract may have in protecting against possible cochlear damage caused by organophosphate pesticides (methamidophos). Anatomic changes are assessed through surface and electron microscopy.


METHODS
This is a prospective experimental study. Twenty-one guinea pigs were given saline solution, pesticide, and ginkgo biloba alone or combined for seven consecutive days. Then their cochleas were removed and examined in a scanning electron microscope.


RESULTS
Pesticide-exposed guinea pigs had morphological alterations in their cochleas and injuries in the three turns analyzed through electron microscopy. Injury intensity varied according to the dosages of the agents given to the test subjects. Guinea pigs treated with pesticide and ginkgo biloba maintained the architecture of their outer hair cells in all cochlear turns.


CONCLUSIONS
The antioxidant properties found in the ginkgo biloba extract protected guinea pigs from pesticide ototoxicity.
Concordia Special Teaching Unit, Speech and Hearing Program, ULBRA.
Andréa Dulor
AD
Finkler
Aron Ferreira da
AF
Silveira
Gisiane
G
Munaro
Crisley Dossin
CD
Zanrosso
D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000648:ultrastructure; D020441:Ginkgo biloba / Q000737:chemistry*; D006168:Guinea Pigs; D008855:Microscopy, Electron, Scanning; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies
D009946:Organothiophosphorus Compounds; D010575:Pesticides; D010936:Plant Extracts; C014655:methamidophos