Quinacrine induced mood disturbance--the unmasking of bipolar affective disorder.
The authors report the case of a 20-year-old man who presented with a de novo episode of hypomania subsequent to the initiation of quinacrine for treatment resistant giardiasis. The hypomanic episode commenced some 20 days after the successful completion of a week long course of quinacrine 100 mg three times daily. The hypomanic episode was treated with olanzapine 10 mg daily. Two months subsequent to this, the patient developed a moderate depressive episode which was treated with escitalopram and olanzapine. One month after the resolution of the depressive episode, he once again presented with a hypomanic episode. The recurring episodes of discrete mood disturbance all occurred within 5 months of the commencement of quinacrine in an individual with no personal history of affective disorders.
Department of Psychiatry, National University of Ireland, Galway (NUIG), Galway, Ireland. john.lally@nuigalway.ie
John
J
Lally
Fintan
F
Byrne
Elizabeth
E
Walsh
D000328:Adult; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005873:Giardiasis / Q000188:drug therapy; D006801:Humans; D008297:Male; D011796:Quinacrine / Q000009:adverse effects*; D055815:Young Adult
D000981:Antiprotozoal Agents; D011796:Quinacrine