Survivin the battle against immunosuppression.
Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to "escape" protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule Stat3, and a Survivin vaccine to suppress growth of aggressive murine tumors.
Division of Translational Vaccine Research; City of Hope; Duarte, CA USA.
Edwin R
ER
Manuel
Céline A
CA
Blache
Joshua D I
JD
Ellenhorn
Don J
DJ
Diamond