NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis.
Published data have implicated NAT2 polymorphisms as risk factors for various cancers. A number of studies have focused on the association of NAT2 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the relationship. We first carried out a deliberate search in the databases without a language limitation, covering all papers published up to Dec 2011. A total of seven case-control studies including 1,379 cases and 1,868 controls were selected and the relevant data were extracted for systematic meta-analyses. No significant association was found for the overall data (OR: 1.04, 95 % CI: 0.79-1.39). In subgroup analyses according to ethnicity, slow acetylators might increase oral cancer risk among Asians (OR: 1.38, 95 % CI: 1.04-1.82) but not Caucasians or Mixed races. The data suggested that NAT2 polymorphisms might be a low-penetrant risk factor for oral carcinoma in Asians.
Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Xian-Lu
XL
Zhuo
Jun-Jun
JJ
Ling
Yan
Y
Zhou
Hou-Yu
HY
Zhao
Yu-Feng
YF
Song
Ying-Hui
YH
Tan
D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human