Vaccine and Immunization Surveillance in Ontario (VISION) - using linked health administrative databases to monitor vaccine safety.
Vaccine safety surveillance is a critical component of any population-wide vaccination program. In the province of Ontario, Canada we developed a vaccine safety surveillance system utilizing linked health administration databases. VISION (Vaccine and Immunization Surveillance in Ontario) has conducted population based self-controlled case series analyses to evaluate the safety of recommended pediatric vaccines in the general population and in specific subgroups. We present our experiences with developing this system including preliminary findings and challenges. Key methodological observations include: (1) aggregate health services data as an endpoint appears useful (2) graphical description of events following vaccination are valuable and (3) relative incidence ratios are helpful for overcoming the healthy vaccinee effect.
Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Administrative Services Building, Room 1009, Box 684, Ottawa, ON K1Y 4E9, Canada. kwilson@ohri.ca
Kumanan
K
Wilson
Steven
S
Hawken
Jeffrey C
JC
Kwong
Shelley L
SL
Deeks
Natasha S
NS
Crowcroft
Douglas
D
Manuel
D016907:Adverse Drug Reaction Reporting Systems; D002648:Child; D016208:Databases, Factual; D006801:Humans; D015994:Incidence; D009864:Ontario; D011159:Population Surveillance; D014611:Vaccination / Q000009:adverse effects; D014612:Vaccines / Q000009:adverse effects*
D014612:Vaccines