Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp.
Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Naonobu
N
Tanaka
Shohei
S
Suto
Haruaki
H
Ishiyama
Takaaki
T
Kubota
Akihito
A
Yamano
Motoo
M
Shiro
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D000818:Animals; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D012717:Sesquiterpenes; C576099:halichonadin K; C576100:halichonadin L