Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections.
Rabbits, mice, rats, non-human primates, sheep and cattle have been used to study the effect of Clostridium perfringens enterotoxin (CPE). CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood.
California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA. fuzal@cahfs.ucdavis.edu
Francisco A
FA
Uzal
Bruce A
BA
McClane
D000818:Animals; D002417:Cattle; D003015:Clostridium Infections / Q000382:microbiology* / Q000473:pathology*; D003016:Clostridium perfringens / Q000472:pathogenicity*; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000633:toxicity; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D051379:Mice; D011188:Potassium / Q000097:blood; D011323:Primates; D011817:Rabbits; D051381:Rats; D012756:Sheep; D037521:Virulence Factors / Q000633:toxicity
D004768:Enterotoxins; D037521:Virulence Factors; C035598:enterotoxin, Clostridium; D011188:Potassium