Vaccenic acid in serum triglycerides is associated with markers of insulin resistance in men.
Serum triglyceride levels are associated with metabolic disorders; however, it remains unclear whether the fatty acid (FA) composition of triglycerides is also changed. Although there were no differences in circulating triglyceride levels between normoglycaemic-normoinsulinaemic and hyperglycaemic-hyperinsulinaemic men, inspection of individual FA revealed that vaccenic acid was enriched with hyperglycaemia-hyperinsulinaemia. Moreover, vaccenic acid levels were positively correlated with insulin and HOMA-IR. This reinforces that examination of individual FA in the context of insulin resistance is warranted.
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Michael A
MA
Zulyniak
Jessica C
JC
Ralston
Amy J
AJ
Tucker
Kathy A
KA
MacKay
Lyn M
LM
Hillyer
Paul D
PD
McNicholas
Terry E
TE
Graham
Lindsay E
LE
Robinson
Alison M
AM
Duncan
David W L
DW
Ma
David M
DM
Mutch
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015930:Diet Records; D005227:Fatty Acids / Q000032:analysis / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D006946:Hyperinsulinism / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009829:Oleic Acids / Q000032:analysis / Q000097:blood*; D025341:Principal Component Analysis; D014280:Triglycerides / Q000097:blood* / Q000737:chemistry
D015415:Biomarkers; D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D009829:Oleic Acids; D014280:Triglycerides; C050413:11-octadecenoic acid