Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation.
A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by (1)H NMR, (13)C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.
National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Avenue, Wuhan 430064, PR China.
Liqiao
L
Shi
Rui
R
Hu
Yanhong
Y
Wei
Ying
Y
Liang
Ziwen
Z
Yang
Shaoyong
S
Ke
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003958:Diamide / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D007555:Isoxazoles / Q000737:chemistry*; D062367:ortho-Aminobenzoates / Q000737:chemistry*
D000970:Antineoplastic Agents; D007555:Isoxazoles; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D003958:Diamide