Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes.
BACKGROUND
The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.


RESULTS
The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with erythromycin (ERY).


CONCLUSIONS
The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.
Department of Biochemistry, Faculty of science, University of Dschang, P,O, Box 67, Dschang, Cameroon, Africa.
Igor K
IK
Voukeng
Victor
V
Kuete
Jean P
JP
Dzoyem
Aimé G
AG
Fankam
Jaures A K
JA
Noumedem
Jules R
JR
Kuiate
Jean-Marie
JM
Pages
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D002163:Cameroon; D024901:Drug Resistance, Multiple, Bacterial; D004357:Drug Synergism; D000432:Methanol / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry*; D017365:Spices
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000432:Methanol; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010936:Plant Extracts; D012997:Solvents