[Effects of penetration enhancers on curcumin transdermal drug delivery].
OBJECTIVE
To study the effects of penetration enhancers and their combinations on the curcumine transdermal drug delivery (CUR-TDDS).


METHODS
The penetration rate of curcumin through rat skin in vitro was measured using Valia-Chien diffusion cells, and orthogonal design method was set up for experimental design.


RESULTS
The optimum penetration enhancers were: 3% hydroxypropyl beta cyclodextrins (HP-beta-CD), 9% borneol and 3% peppermint oil.


CONCLUSIONS
The HP-beta-CD has the most potent enhancing effect.
College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn
Zhen-Shen
ZS
Gao
Lan
L
Wang
Mei
M
Zhang
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000279:Administration, Cutaneous; D000818:Animals; D001892:Camphanes / Q000008:administration & dosage / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D036142:Mentha piperita; D051379:Mice; D008813:Mice, Inbred ICR; D010539:Permeability / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D057968:Transdermal Patch; D047392:beta-Cyclodextrins / Q000008:administration & dosage* / Q000494:pharmacology
D001892:Camphanes; D004337:Drug Carriers; D010938:Plant Oils; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C015424:peppermint oil; D003474:Curcumin; C022871:isoborneol