Research on neurodegenerative diseases using induced pluripotent stem cells.
Induced pluripotent stem cells (iPSC) are derived from somatic cells. These somatic cells have had their gene expression experimentally reprogrammed to an embryonic stem cell-like pluripotent state, gaining the capacity to differentiate various cell types in the three embryonic germ layers. Thus, iPSC technology makes it possible to obtain neuronal cells from any human cells. iPSC can be generated from various kinds of somatic cells and from patients with neurodegenerative diseases. Disease modelling using iPSC technology would elucidate the pathogenesis of such diseases and contribute to related drug discoveries. In this review, we discuss the recent advances in iPSC technology as well as its potential applications.
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Keiko
K
Imamura
Haruhisa
H
Inoue
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D004252:DNA Mutational Analysis; D004195:Disease Models, Animal; D055808:Drug Discovery; D004402:Dysautonomia, Familial / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D005091:Exons / Q000235:genetics; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D009134:Muscular Atrophy, Spinal / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D012333:RNA, Messenger / Q000235:genetics; D055533:Survival of Motor Neuron 1 Protein / Q000235:genetics; D055540:Survival of Motor Neuron 2 Protein / Q000235:genetics; D035602:Transcriptional Elongation Factors
D002352:Carrier Proteins; C114720:Elp1 protein, human; D012333:RNA, Messenger; C526471:SMN1 protein, human; C526477:SMN2 protein, human; D055533:Survival of Motor Neuron 1 Protein; D055540:Survival of Motor Neuron 2 Protein; D035602:Transcriptional Elongation Factors