Magnetic response of mitochondria-targeted cancer cells with bacterial magnetic nanoparticles.
We first demonstrate the effects of magnetic trapping of mitochondria using aptamer conjugated to bacterial magnetic nanoparticles that allowed targeting of the mitochondrial cytochrome c in the treatment of cancer cells. Our findings offer a new approach for targeted cell therapy, with the advantage of remote control over subcellular elements.
Interdisciplinary Program of Bioengineering, Seoul National University, San 56-1, Shinlim, Kwanak, Seoul, 151-742, Korea.
Jungin
J
Choi
Jaeha
J
Shin
Junghoon
J
Lee
Misun
M
Cha
D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000494:pharmacology*; D016923:Cell Death; D045304:Cytochromes c / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D060526:Magnetic Fields; D055944:Magnetosomes / Q000378:metabolism* / Q000648:ultrastructure; D042201:Magnetospirillum / Q000648:ultrastructure; D008928:Mitochondria / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*
D052157:Aptamers, Nucleotide; D045304:Cytochromes c