Need for a well-balanced sunscreen to protect human skin from both Ultraviolet A and Ultraviolet B damage.
Skin exposure to sunlight can cause many adverse effects. It is now recognized that both Ultraviolet A (UVA) and UVB wavelengths are responsible for the detrimental effects of solar radiation on skin. With our increasing knowledge on the harmful effects of UVA, the need for effective, well-balanced photoprotection has become more crucial. Numerous clinical studies showed that well-balanced sunscreen, with a SPF/UVAPF ratio ≤ 3, provide the most effective protection against pigmentation (especially on dark skin), DNA damage, UV-induced skin immunosuppression and photodermatoses. The calculation of UVA protection required in Asia revealed its particular importance in India, and gives clear evidence that the SPF value alone is not sufficient to evaluate the efficacy of a sunscreen.
L'Oréal Research and Innovation, France.
Dominique
D
Moyal
D001208:Asia; D004249:DNA Damage / Q000528:radiation effects; D004268:DNA-Binding Proteins / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007108:Immune Tolerance / Q000528:radiation effects; D010787:Photosensitivity Disorders / Q000517:prevention & control*; D012867:Skin / Q000528:radiation effects*; D012880:Skin Pigmentation / Q000528:radiation effects; D013472:Sunlight; D013473:Sunscreening Agents / Q000627:therapeutic use*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004268:DNA-Binding Proteins; C478985:PDRG1 protein, human; D013473:Sunscreening Agents