Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction.
Total parenteral nutrition (TPN) administration in a mouse model leads to a local mucosal inflammatory response, resulting in a loss of epithelial barrier function (EBF). Although, the underlying mechanisms are unknown, a major contributing factor is a loss of growth factors and subsequent critical downstream signaling. An important component of these is the p-Akt pathway. An additional contributing factor to the loss of EBF with TPN is an increase in proinflammatory cytokine abundance within the mucosal epithelium, including TNF-α and IFN-γ. Loss of critical nutrients, including glutamine and glutamate, may affect EBF, contributing to the loss of tight junction proteins. Finding protective modalities for the small intestine during TPN administration may have important clinical applications. Supplemental glutamine and glutamate may be examples of such agents.
Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Yongjia
Y
Feng
Matthew W
MW
Ralls
Weidong
W
Xiao
Eiichi
E
Miyasaka
Richard S
RS
Herman
Daniel H
DH
Teitelbaum
D000818:Animals; D004750:Enteral Nutrition; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D051379:Mice; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D019108:Tight Junctions
D036341:Intercellular Signaling Peptides and Proteins; D051057:Proto-Oncogene Proteins c-akt