Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive antibodies in Ishikawa Prefecture, Japan.
Previous reports of multiple sclerosis (MS) with autoantibodies might include neuromyelitis optica (NMO). We investigated the frequency of autoreactive antibodies (AR) in both MS and NMO. Systemic lupus erythematosus (SLE)-associated autoantibodies such as anti-Sm antibodies, anti-single stranded DNA antibodies and lupus anticoagulants were only identified in MS, whereas SLE itself is more commonly associated with NMO. Moreover, when magnetic resonance imaging features between autoreactive antibody-positive (AR(+))MS and -negative (AR(-))MS were compared, AR(+)MS cases showed significantly fewer than 3 periventricular lesions compared to AR(-)MS cases. These results may indicate different pathogenetic mechanisms underlying AR(+)MS and AR(-)MS.
Department of Neurology, National Hospital Organization Iou Hospital, Ni73-1, Iwade-machi, Kanazawa 920-0192, Japan. ktakaha@ioudom.hosp.go.jp
Kazuya
K
Takahashi
Keiko
K
Tanaka
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000134:cerebrospinal fluid / Q000276:immunology*; D002490:Central Nervous System / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000276:immunology* / Q000473:pathology; D055815:Young Adult
D001323:Autoantibodies