Echocardiographic epicardial fat thickness is associated with arterial stiffness.
BACKGROUND
Epicardial adipose tissue represents visceral adiposity, the early detection of which could be helpful for assessing subclinical target organ damage. Although previous studies have reported a relationship between epicardial fat thickness (EFT) and carotid intima-media thickness, there have been no studies detailing the relationship between EFT and brachial-ankle pulse wave velocity (baPWV).


METHODS
We consecutively enrolled 655 subjects (445 men, 55 ± 9 years) who underwent echocardiography and baPWV and had an ankle-brachial index greater than 0.95. The subjects were divided into four quartile groups depending on EFT. Subjects were also classified into two groups according to baPWV: group I (324 subjects), baPWV ≤ 1366 cm/s, and group II (331 subjects), baPWV>1366 cm/s.


RESULTS
The EFT in group II was significantly higher than in group I (4.2mm vs. 3.7 mm, p<0.001). There were significant differences in baPWV values among the EFT quartile groups (quartile I, 1327 ± 148.8 cm/s; quartile II, 1371 ± 215.0 cm/s; quartile III, 1434 ± 228.3 cm/s; quartile IV, 1507 ± 233.1 cm/s; p-value<0.001). In multivariate regression models, the highest quartile groups of EFT had higher odds ratios (ORs) for increased baPWV compared with that of the lowest quartile group (OR [95% confidence interval (CI)]: 2.19[1.21-3.95]), irrespective of confounding factors. Moreover, EFT was an independent determinant of baPWV (standard β=0.113, p=0.001).


CONCLUSIONS
This study demonstrates an independent relationship between EFT and arterial stiffness, suggesting that echocardiographic EFT measurement could be an easy-to-measure tool for early detection of subclinical target organ damage.
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Republic of Korea. bjjake.kim@samsung.com
Byung Jin
BJ
Kim
Bum Soo
BS
Kim
Jin Ho
JH
Kang
D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000502:physiology; D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index / Q000379:methods; D059168:Carotid Intima-Media Thickness / Q000009:adverse effects; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging* / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology