Imaging the interaction: epileptic discharges, working memory, and behavior.
Interictal generalized epileptiform discharges may impair cognition. We used simultaneous video-electroencephalography and functional imaging to quantify changes, induced by epileptiform discharges, in the task-related activations during a spatial working-memory paradigm. The number of epileptiform discharges increased during the task with its level of complexity, but were not significantly associated with wrong responses during the task. We observed hemodynamic responses in working-memory related frontal-lobe-network, motor-cortex, precuneus, and parietal lobes in the absence of epileptiform discharges. In the presence of epileptiform discharges during the task, task-related hemodynamic changes were seen only in motor-cortex, precuneus, and parietal lobes. These findings suggest that generalized epileptiform discharges during a high demanding working memory task may change the working memory-related hemodynamic responses in frontal-lobe-network.
DCEE, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom; MRI Unit, Epilepsy Society, Chalfont St. Peter, SL9 0RJ, United Kingdom.
Umair J
UJ
Chaudhary
Maria
M
Centeno
David W
DW
Carmichael
Christian
C
Vollmar
Roman
R
Rodionov
Silvia
S
Bonelli
Jason
J
Stretton
Ronit
R
Pressler
Sofia H
SH
Eriksson
Sanjay
S
Sisodiya
Karl
K
Friston
John S
JS
Duncan
Louis
L
Lemieux
Matthias
M
Koepp
D000328:Adult; D001519:Behavior / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D016001:Confidence Intervals; D017352:Echo-Planar Imaging; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000523:psychology; D004829:Epilepsy, Generalized / Q000473:pathology / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000473:pathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008570:Memory, Short-Term / Q000502:physiology*; D009044:Motor Cortex / Q000098:blood supply / Q000473:pathology; D009415:Nerve Net / Q000098:blood supply / Q000473:pathology; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000473:pathology; D011597:Psychomotor Performance / Q000502:physiology; D012640:Seizures / Q000473:pathology / Q000523:psychology
D010100:Oxygen