The interplay of monolayer structure and serum protein interactions on the cellular uptake of gold nanoparticles.
A critical factor for controlling serum albumin binding is surface hydrophobicity, which in turn decreases the cellular uptake of gold nanoparticles. Hydrophobic nanoparticles bind albumin more tightly, inhibiting particle uptake, with a direct correlation observed between uptake and surface hydrophobicity.
Department of Chemistry, University of Massachusetts, Amherst, 01003 USA.
Zheng-Jiang
ZJ
Zhu
Tamara
T
Posati
Daniel F
DF
Moyano
Rui
R
Tang
Bo
B
Yan
Richard W
RW
Vachet
Vincent M
VM
Rotello
D001798:Blood Proteins / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D053768:Metal Nanoparticles
D001798:Blood Proteins; D006046:Gold