A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.
MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Katja
K
Branitzki-Heinemann
Cheryl Y
CY
Okumura
Lena
L
Völlger
Yuko
Y
Kawakami
Toshiaki
T
Kawakami
Hassan Y
HY
Naim
Victor
V
Nizet
Maren
M
Von Köckritz-Blickwede
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002478:Cells, Cultured; D004448:Echinomycin / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology*; D015850:Interleukin-6 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D008407:Mast Cells / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010879:Piperazines / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000472:pathogenicity
C575838:AKB-4924; D000890:Anti-Infective Agents; C497442:HIF1A protein, human; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D015850:Interleukin-6; D016209:Interleukin-8; D010879:Piperazines; D011728:Pyridones; D004448:Echinomycin