Zinc and vitamin A can minimise the severity of oral submucous fibrosis.
We report a case of a 24-year-old man who presented with a complaint of reduced mouth opening and a burning sensation. On examination, he was clinically diagnosed with oral submucous fibrosis (OSF). Following routine biopsy and histopathological confirmation of OSF, the patient was supplemented with zinc acetate along with vitamin A and was followed up for 4 months. Following treatment the patient reported increased mouth opening and a reduced burning sensation. Histopathologically re-epithelialisation was evident along with the appearance of normal rete pegs. The data for mouth opening, collagen content and epithelial thickness of six other cases similarly treated are also presented, showing a significant increase in mouth opening and epithelial thickness and decrease in collagen content. We propose the use of zinc acetate and vitamin A for the management of OSF.
Dr R Ahmed Dental College & Hospital, Kolkata-700014, India, Oral and Maxillofacial Pathology, 114, Acharya Jagadish Chandra Bose Road, Kolkata, 700014, India.
Richa
R
Dhariwal
Sanjit
S
Mukherjee
Sweta Pattanayak
SP
Mohanty
Avirup
A
Chakraborty
Jay Gopal
JG
Ray
Keya
K
Chaudhuri
D000284:Administration, Oral; D001706:Biopsy; D006801:Humans; D008297:Male; D009914:Oral Submucous Fibrosis / Q000175:diagnosis / Q000188:drug therapy*; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult; D019345:Zinc Acetate / Q000008:administration & dosage / Q000627:therapeutic use*
D014801:Vitamin A; D019345:Zinc Acetate