Fe and Cu do not differ in Parkinson's disease: a replication study plus meta-analysis.
To evaluate whether iron and copper levels in serum, plasma, and cerebrospinal fluid are disarranged in Parkinson's disease (PD), we performed meta-analyses of 33 studies on the topic published from 1987 to 2011 and contextually carried out a replication study in serum by ourselves as well. We found no variation in metals between PD patients and healthy controls, according to our replication study. The metaregression for sex revealed that serum copper differences found in some studies could be referred to the different percentage of women in the PD sample. Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.
Department of Neurology, Campus Bio-Medico University, Rome, Italy. s.mariani@unicampus.it
Stefania
S
Mariani
Mariacarla
M
Ventriglia
Ilaria
I
Simonelli
Silvia
S
Donno
Serena
S
Bucossi
Fabrizio
F
Vernieri
Jean-Marc
JM
Melgari
Patrizio
P
Pasqualetti
Paolo M
PM
Rossini
Rosanna
R
Squitti
D000328:Adult; D003300:Copper / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D003300:Copper; D007501:Iron