Lymph node vascular-stromal growth and function as a potential target for controlling immunity.
Lymphadenopathy occurs in many autoimmune and inflammatory diseases, and vascular proliferation is a common feature in the enlarged lymph nodes. The lymph node vasculature plays critical roles in delivering immune cells as well as oxygen and micronutrients, and therefore represents a potential target for therapeutic manipulation of immunity. In this review, we discuss recent insights made in understanding the growth and function of the vascular and associated stromal compartment in immune-stimulated lymph nodes and the potential utility of altering this process in autoimmune diseases.
Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA. BenahmedF@hss.edu
Fairouz
F
Benahmed
Scott
S
Ely
Theresa T
TT
Lu
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D001808:Blood Vessels / Q000166:cytology; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008198:Lymph Nodes / Q000098:blood supply* / Q000276:immunology*; D042601:Lymphatic Vessels / Q000166:cytology*; D017154:Stromal Cells / Q000166:cytology