[Causes and consequences of glycated hemoglobin variability on pediatric population].
BACKGROUND
Type one diabetes mellitus is the second most frequent disease in childhood, presenting with serious complications when inadequately controlled. The most useful measure of metabolic control is hemoglobin A1c (HbA1c), being essential the awareness of the causes of its variability.


OBJECTIVE
to evaluate the effect of age and time of disease on HbA1c; to evaluate the relationship between HbA1c and serum lipid and microalbuminuria values.


METHODS
Observational, transversal and analytic study, based on data obtained in the files of all patients that attain the Pediatric Diabetic Consult. The studied variables were: sex, actual age, diagnostic age, metabolic control and chronic complications. Statistical analysis was made with Excel2003® and SPSS 15.0®. A significance level of 5% was adopted.


RESULTS
a 96 diabetic population was obtained. Last year HbA1c average was 8,3% and was less than 7,5% in one third of the cases. Adolescent's HbA1c (8,4%) was significantly higher than in children (7,8%) (p=0,03). Diabetics with a disease longer than five years presented higher HbA1c values (9% vs. 7,8%; p<0,01). Microalbuminuria was present in 9% and lipid abnormalities in 10%. The ones with dyslipidemia had a significantly higher HbA1c (9,7% vs. 8%; p=0,001) as well as the ones with microalbuminuria (10% vs. 8%; p<0,001).


CONCLUSIONS
In this study it was verified that adolescents and diabetics with a longer time of disease have higher HbA1c. It was also verified that the consequences of a poor metabolic control, such as microalbuminuria and lipid disorder, can be observed even at pediatric age.
Consulta de Diabetologia Infantil, Serviço de Pediatria, Hospital de São Teotónio, Viseu, Portugal.
Maria Inês
MI
Santos
Catarina
C
Resende
Frederico
F
Rosário
Joana
J
Campos
Graça
G
Carvalho
Cecília
C
Figueiredo
D000293:Adolescent; D000419:Albuminuria / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D055815:Young Adult
D006442:Glycated Hemoglobin