Single-step radiofluorination of peptides using continuous flow microreactor.
18F radiolabelling of peptides bearing two different prosthetic groups was successfully conducted in a continuous flow microfluidic device for the first time. Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome. Rapid reaction optimization was possible.
Center for Radiopharmaceutical Sciences, ETH Zurich, Zurich, Switzerland.
Svetlana V
SV
Selivanova
Linjing
L
Mu
Johanna
J
Ungersboeck
Timo
T
Stellfeld
Simon M
SM
Ametamey
Roger
R
Schibli
Wolfgang
W
Wadsak
D005462:Fluorine Radioisotopes / Q000737:chemistry; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*
D005462:Fluorine Radioisotopes; D010455:Peptides