Severe dyslipidaemia after the addition of raltegravir to a lopinavir/ritonavir-containing regimen.
We describe a 55-year-old HIV-1-infected male who developed severe dyslipidaemia (total cholesterol 600 mg/dl, triglycerides >5,000 mg/dl, high density lipoprotein <5 mg/dl) after raltegravir was added to his lopinavir/ritonavir-containing regimen. To our knowledge, this is the first reported case of severe dyslipidaemia associated with the addition of raltegravir to a lopinavir/ritonavir-based regimen, suggestive of a possible drug interaction. The lipid profile quickly normalized following discontinuation of lopinavir/ritonavir and continuation of raltegravir, suggesting that lopinavir/ritonavir was the primary driver for the adverse event. With increasing interest in nucleoside-sparing regimens, knowledge of clinically significant adverse events such as this is important for HIV clinicians when selecting regimens for patients with highly resistant virus or drug tolerability issues.
Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, USA.
Emily
E
Huesgen
Rodrigo
R
Burgos
Debra A
DA
Goldstein
Blake
B
Max
Olamide D
OD
Jarrett
D008076:Cholesterol, HDL / Q000097:blood; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000139:chemically induced* / Q000473:pathology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D061466:Lopinavir / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011760:Pyrrolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D019438:Ritonavir / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D017320:HIV Protease Inhibitors; D011760:Pyrrolidinones; D014280:Triglycerides; D061466:Lopinavir; D000068898:Raltegravir Potassium; D019438:Ritonavir