Proteoglycan metabolism, cell death and Kashin-Beck disease.
Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan metabolism and loss of proteoglycans in articular cartilage from KBD patients has been observed. In this mini-review, we discuss the close relationship between chondrocyte death including necrosis and loss of proteoglycan, and its potential mechanism during KBD onset and development, which may provide new clues for KBD research.
Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, China.
Siyuan
S
Li
Junling
J
Cao
Bruce
B
Caterson
Clare E
CE
Hughes
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death; D002648:Child; D002675:Child, Preschool; D019902:Chondrocytes / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D057767:Kashin-Beck Disease / Q000378:metabolism* / Q000473:pathology; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism*; D051381:Rats
D016207:Cytokines; D011509:Proteoglycans