Curcumin encapsulation in submicrometer spray-dried chitosan/Tween 20 particles.
Optimal curcumin delivery for medicinal applications requires a drug delivery system that both solubilizes curcumin and prevents degradation. To achieve this, curcumin has been encapsulated in submicrometer chitosan/Tween 20 particles via a benchtop spray-drying process. Spray-drying parameters have been optimized using a Taguchi statistical approach to minimize particle size and to favor spheroid particles with smooth surfaces, as evaluated with scanning electron microscopy (SEM) imaging. Nearly spherical particles with 285 ± 30 nm diameter and 1.21 axial ratio were achieved. Inclusion of curcumin in the spray-drying solution results in complete encapsulation of curcumin within the chitosan/Tween 20 particles. Release studies confirm that curcumin can be released completely from the particles over a 2 h period.
Department of Bioengineering, University of Louisville, Louisville, Kentucky 40292, United States.
Martin G
MG
O'Toole
Richard M
RM
Henderson
Patricia A
PA
Soucy
Brigitte H
BH
Fasciotto
Patrick J
PJ
Hoblitzell
Robert S
RS
Keynton
William D
WD
Ehringer
Andrea S
AS
Gobin
D048271:Chitosan / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D003902:Detergents / Q000737:chemistry*; D004339:Drug Compounding; D008855:Microscopy, Electron, Scanning; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D003902:Detergents; D053769:Nanocapsules; D011136:Polysorbates; D048271:Chitosan; D003474:Curcumin