Effect of diet-induced weight loss on inflammatory cytokines in obese women.
BACKGROUND
Obesity is associated with lowgrade systemic inflammation which has been linked to the increased risk of cardiovascular disease and Type 2 diabetes in obese patients.


OBJECTIVE
To evaluate changes in pro/anti-inflammatory adipocytokines and metabolic profile after moderate diet-induced weight loss.


METHODS
Twenty-nine pre-menopausal obese women (body mass index ≥30 kg/m2) aged 21 to 54 years without diabetes, hypertension, or hyperlipidemia, were enrolled in this study. We measured anthropometric parameters, lipid and glucose profiles, interleukin (IL)-6, IL-10, and IL-18 in obese women, who then entered a medically supervised program aimed at reducing body weight by 10% or more. Obese women restricted their caloric intake (by 500-1000 kcal/day) and consumed 50 g/day of a fiber supplement (Slim Last Powder) for 12 weeks.


RESULTS
By completing the dietary intervention program, weight (Δ = -10.0%, p<0.0001), body mass index, waist circumference, triceps skinfold thickness, total cholesterol, triglyceride, and fasting plasma glucose significantly decreased, while HDL-cholesterol significantly increased. While plasma levels of IL-6 and IL-18 decreased by 27% after 12 weeks, no significant change was observed in circulating levels of IL-10.


CONCLUSIONS
Our study suggests that an improved body composition induced by restriction of energy intake is associated with favorable serum concentrations of IL-6 and IL-18 in obese women. However, the anti-inflammatory IL-10 is not affected by a moderate weight decrease.
Nutrition and Biochemistry Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
N
N
Tajik
S A
SA
Keshavarz
F
F
Masoudkabir
M
M
Djalali
H Hale
HH
Sadrzadeh-Yeganeh
M R
MR
Eshraghian
M
M
Chamary
Z
Z
Ahmadivand
T
T
Yazdani
M H
MH
Javanbakht
D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D004038:Diet, Reducing / Q000379:methods; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000178:diet therapy* / Q000276:immunology; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000276:immunology / Q000502:physiology*; D055815:Young Adult
D016207:Cytokines; D018836:Inflammation Mediators; D020382:Interleukin-18; D015850:Interleukin-6; D014280:Triglycerides; D016753:Interleukin-10