Type 2C protein phosphatases in plants.
Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg(2+)-/Mn(2+)-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.
Department of Botany, Technische Universität München, Freising, Germany.
Stefan
S
Fuchs
Erwin
E
Grill
Irute
I
Meskiene
Alois
A
Schweighofer
D000040:Abscisic Acid / Q000378:metabolism / Q000494:pharmacology; D019143:Evolution, Molecular; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D008958:Models, Molecular; D010749:Phosphoprotein Phosphatases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D010937:Plant Growth Regulators / Q000378:metabolism / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D000071636:Protein Phosphatase 2C; D017434:Protein Structure, Tertiary
D010937:Plant Growth Regulators; D010940:Plant Proteins; D000040:Abscisic Acid; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C