[Current aspects of sepsis caused by bacterial translocation].
Bacterial translocation has been put forward as a concept to explain sepsis without an infectious focus, but it has been difficult to prove in humans. Dysfunction of the intestinal barrier, which is composed of physical, biochemical and immunological factors, is the pathophysiological prerequisite for bacterial translocation. Recent findings indicate that not only viable bacteria but also pathogen associated molecular patterns may translocate and cause sepsis. Molecular detection methods for bacteria or their components have been developed to address these new concepts, but they have not yet become widely available. Specific therapeutic interventions within the sepsis cascades and signaling pathways of the innate and specific immune system so far have not been successful. Selective oral decontamination (SOD) und selective digestive tract decontamination (SDD) are efficacious prophylactic measures against nosocomial septic complications. An increased incidence of resistant pathogens has not been encountered. The use of probiotics as prophylaxis against septic complications is controversial and has led in some studies to a worse prognosis.
Universitätsklinik Tübingen, Medizinische Klinik. georg.lamprecht@med.unirostock.de
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Heininger
D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology / Q000517:prevention & control; D018988:Bacterial Translocation / Q000276:immunology / Q000502:physiology; D003428:Cross Infection / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D007121:Immunocompetence / Q000502:physiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D007422:Intestines / Q000098:blood supply; D011379:Prognosis; D015427:Reperfusion Injury / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control; D018805:Sepsis / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology / Q000517:prevention & control; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology