Role of epoxide hydrolases in lipid metabolism.
Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host defense, control of development, regulation of blood pressure, inflammation, and pain. In general, the bioactivity of these natural epoxides is significantly reduced upon metabolism to diols. Thus, through the regulation of the titer of lipid epoxides, EHs have important and diverse biological roles with profound effects on the physiological state of the host organism. This review will discuss the biological activity of key lipid epoxides in mammals. In addition, the use of EH specific inhibitors will be highlighted as possible therapeutic disease interventions.
Department of Entomology and U.C.D. Comprehensive Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA. chmorisseau@ucdavis.edu
Christophe
C
Morisseau
D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism; D007605:Juvenile Hormones / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D008322:Mammals; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism; D012995:Solubility
D004852:Epoxy Compounds; D007605:Juvenile Hormones; C002415:cholesterol alpha-oxide; D002784:Cholesterol; D004851:Epoxide Hydrolases