The KHOALA cohort of knee and hip osteoarthritis in France.
OBJECTIVE
This study aimed to describe the prevalence of symptomatic knee and hip osteoarthritis (OA) and its course over time, as well as identify prognostic factors of OA course and determinants of costs and access to care in France in a patient cohort.


METHODS
Subjects aged 40 to 75 years, with uni- or bilateral symptomatic hip and/or knee OA (ACR criteria), Kellgren and Lawrence (KL) stage 2 or greater, were recruited from a French national prevalence survey for the multicenter KHOALA cohort study. Data collected at baseline included sociodemographic and clinical data; WOMAC, IKS and Harris scores for pain and function; MAQ score for physical activity; functional comorbidity index; GHQ28 score for psychological status; and SF-36 (generic) and OAKHQOL (specific) scores for quality of life. Blood and urine samples were collected.


RESULTS
Eight hundred and seventy-eight subjects were included, 222 with OA of the hip (mean age 61.2±8.8 years), 607 knee (mean age 62.0±8.5 years) and 49 both hip and knee (mean age 64.9±7.9 years). Mean body mass index was 26.9±4.5 for hip OA and 30.3±6.3 for knee OA. Hip and knee OA patients had 1.99 and 2.06 comorbidities, on average, respectively. Disease severity on X-rays for KL stages 2, 3 and 4 for hip OA was 69.8, 26.1 and 4.1%, respectively, and for knee OA, 44.5, 30.3, and 25.2%. As compared with population norms, age- and sex-standardized SF-36 scores were greatly decreased for both knee and hip OA in all dimensions, particularly physical and emotional dimensions.


CONCLUSIONS
Patients will be followed up annually, alternately by mail and clinical visit. This cohort of representative patients with knee and hip OA will be an opportunity for future collaborative research.
Lorraine University, Paris Descartes University, EA 4360 Apemac, France. francis.guillemin@chu-nancy.fr
Francis
F
Guillemin
Anne-Christine
AC
Rat
Christian H
CH
Roux
Bruno
B
Fautrel
Bernard
B
Mazieres
Xavier
X
Chevalier
Liana
L
Euller-Ziegler
Patrice
P
Fardellone
Evelyne
E
Verrouil
Johanne
J
Morvan
Jacques
J
Pouchot
Joel
J
Coste
Alain
A
Saraux
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D017048:Health Care Costs; D006297:Health Services Accessibility; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000175:diagnosis* / Q000191:economics / Q000453:epidemiology*; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000191:economics / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index