DLK: the "preconditioning" signal for axon regeneration?
In this issue of Neuron, Shin et al. (2012) show that the dual leucine zipper kinase (DLK) is responsible for the retrograde injury signal in spinal sensory and motor neurons. DLK is required for the accelerated regeneration seen after axotomy and for the improved regeneration seen after a conditioning injury. DLK KO axons have severely reduced axon regeneration in vivo.
Biology Department, University of Utah, Salt Lake City, UT 84112, USA.
Paola
P
Nix
Michael
M
Bastiani
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000502:physiology*; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D009046:Motor Neurons / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D020930:MAP Kinase Kinase Kinases; C090757:mitogen-activated protein kinase kinase kinase 12