The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI-ET treatment.
Chromosomal polymorphism has been reported to be associated with infertility, but its effect on IVF/ICSI-ET outcome is still controversial. To evaluate whether or not chromosomal polymorphism in men plays a role in spermatogenesis and the outcome of IVF/ICSI-ET, we retrospectively analysed 281 infertile couples. Measures included fertilization rate, implantation rate, pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, early miscarriage rate and preterm rate. Men with chromosomal polymorphism had significantly higher frequencies of severe oligozoospermia and azoospermia than those without (37.12% vs. 16.11%, p < 0.001; 27.27% vs. 10.74%, p < 0.001; respectively). Significantly, lower fertilization rate (68.02% vs. 78.00%, p < 0.001) and clinical pregnancy rate (45.00% vs. 66.67%, p = 0.031) were observed in polymorphism-carrying men with severe oligozoospermia compared with non-carriers with severe oligozoospermia. This suggests that chromosomal polymorphism has adverse effects on spermatogenesis, negatively influencing the outcome of IVF/ICSI-ET treatment. Polymorphic variations on the Y chromosome have been found to be the most prevalent polymorphism in infertile men, most frequently occurring in patients with severe oligozoospermia.
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
T
T
Guo
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
Y
Y
Qin
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
X
X
Gao
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
H
H
Chen
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
G
G
Li
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
J
J
Ma
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.|The Key Laboratory for Reproductive Endocrinology of Ministry of Education; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China.
Z-J
ZJ
Chen
D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis