Modulation of DNA repair genes induced by TLR9 agonists: A strategy to eliminate "altered" cells?
We provided evidence that the TLR9 engagement of innate immune cells present in the tumor microenvironment by CpG-oligodeoxynucleotide (CpG-ODN) induces down-modulation of DNA repair gene expression in tumor cells, sensitizing cancer cells to DNA-damaging chemotherapy. These findings expand the benefits of CpG-ODN therapy beyond induction of a strong immune response.
Department of Human Morphology and Biomedical Sciences "Città Studi"; Università degli Studi di Milano; Milan, Italy ; Molecular Targeting Unit Fondazione IRCCS; Istituto Nazionale Tumori; Milan, Italy.
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