Cardiovascular phenotype in Turner syndrome--integrating cardiology, genetics, and endocrinology.
Cardiovascular disease is emerging as a cardinal trait of Turner syndrome, being responsible for half of the 3-fold excess mortality. Turner syndrome has been proposed as an independent risk marker for cardiovascular disease that manifests as congenital heart disease, aortic dilation and dissection, valvular heart disease, hypertension, thromboembolism, myocardial infarction, and stroke. Risk stratification is unfortunately not straightforward because risk markers derived from the general population inadequately identify the subset of females with Turner syndrome who will suffer events. A high prevalence of endocrine disorders adds to the complexity, exacerbating cardiovascular prognosis. Mounting knowledge about the prevalence and interplay of cardiovascular and endocrine disease in Turner syndrome is paralleled by improved understanding of the genetics of the X-chromosome in both normal health and disease. At present in Turner syndrome, this is most advanced for the SHOX gene, which partly explains the growth deficit. This review provides an up-to-date condensation of current state-of-the-art knowledge in Turner syndrome, the main focus being cardiovascular morbidity and mortality. The aim is to provide insight into pathogenesis of Turner syndrome with perspectives to advances in the understanding of genetics of the X-chromosome. The review also incorporates important endocrine features, in order to comprehensively explain the cardiovascular phenotype and to highlight how raised attention to endocrinology and genetics is important in the identification and modification of cardiovascular risk.
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.
Kristian H
KH
Mortensen
Niels H
NH
Andersen
Claus H
CH
Gravholt
D002318:Cardiovascular Diseases / Q000209:etiology* / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006330:Heart Defects, Congenital / Q000209:etiology / Q000235:genetics; D006728:Hormones / Q000378:metabolism; D006801:Humans; D012307:Risk Factors; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics
D006728:Hormones