CCR5 in cancer immunotherapy: More than an "attractive" receptor for T cells.
Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5 expression by both CD4+ and CD8+ T cells is necessary to boost anti-tumor responses by optimizing helper-dependent CD8+ T cell priming. Our findings could have implications for cancer treatment in patients with defective CCR5 expression.
Department of Immunology and Oncology; Centro Nacional de Biotecnología CNB/CSIC; Darwin 3; Campus Cantoblanco; Madrid, Spain.
Alicia
A
González-Martín
Emilia
E
Mira
Santos
S
Mañes