The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis.
Changes of platelet count (PLT) and platelet parameters have been reported in iron deficiency anemia (IDA). However, the relationship between iron metabolism and thrombopoiesis is not yet fully known. We studied the relationship between iron and platelet parameters in women with IDA and thrombocytosis. Forty-one adult women with IDA and thrombocytosis were enrolled. The relationship between iron parameters (such as serum iron, serum ferritin, total iron-binding capacity (TIBC)C, and transferrin saturation (Tfsat)), and platelet parameters (PLT, platelet crit (PCT), mean platelet volume (MPV), mean platelet component (MPC), mean platelet mass, platelet distribution width, and large platelet (LPLT)), which measured with CBC on ADVIA, were investigated. In addition, the difference in platelet and iron parameters between severe IDA (Hb < 7 g/dl) and non-severe IDA were compared. PLT inversely correlated with serum iron and Tfsat (p < 0.05). Serum iron and TIBC revealed no significant relationships with any platelet parameters. PLT, PCT, and MPV inversely correlated with mean corpuscular hemoglobin concentration (MCHC) but MPC exhibited linear correlation with Hb, hematocrit, and MCHC (p < 0.05). PCT had linear correlation with PLT and MPV (p < 0.001), whereas PCT, MPV, and LPLT (p < 0.001 for two formers, p < 0.05) inversely correlated with MPC. In this study, the important iron parameters affecting PLT were serum iron and Tfsat. In addition, patients with more severe and hypochromic anemia had higher PLT, PCT, and MPV.
Departments of Laboratory Medicine, Gachon University Gil Medical Center, Incheon, Korea.
Mi-Jung
MJ
Park
Pil-Whan
PW
Park
Yiel-Hea
YH
Seo
Kyung-Hee
KH
Kim
Soon-Ho
SH
Park
Ji-Hun
JH
Jeong
Jeong-Yeal
JY
Ahn
D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010976:Platelet Count; D010979:Platelet Function Tests; D013922:Thrombocytosis / Q000097:blood / Q000209:etiology / Q000378:metabolism*
D007501:Iron