Simultaneous development of acute disseminated encephalomyelitis and Guillain-Barré syndrome associated with H1N1 09 influenza vaccination.
A 36-year-old man was admitted to our hospital because of urinary retention and muscle weakness affecting all 4 limbs after receiving a H1N1 09 influenza vaccination. Magnetic resonance imaging demonstrated multiple lesions in his brain and spinal cord. Furthermore, nerve conduction study showed acute sensorimotor neuropathy, and anti-GM2 antibodies were detected in his serum. Based on the temporal association and exclusion of alternative etiologies, we made a diagnosis of acute disseminated encephalomyelitis (ADEM) and Guillain-Barré syndrome (GBS). To our knowledge, this is the first case of co-morbid ADEM and GBS after influenza vaccination with positive anti-ganglioside antibodies.
Department of Neurology, Tokyo Women's Medical University, Japan. thoshino@nij.twmu.ac.jp
Takao
T
Hoshino
Yumiko
Y
Uchiyama
Eiichi
E
Ito
Shunsuke
S
Osawa
Takashi
T
Ohashi
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005678:G(M2) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male
D001323:Autoantibodies; D007252:Influenza Vaccines; D005678:G(M2) Ganglioside