Spontaneous bacterial peritonitis due to carbapenemase-producing Klebsiella pneumoniae:  the last therapeutic challenge.
Multidrug-resistant infections represent an increasing problem in the management of hospitalized patients worldwide. With respect to Gram-negative infections, carbapenems are an important antimicrobial class for the treatment of infections caused by extended-spectrum beta lactamase producers enterobacteriaceae. However, the emergence of novel β-lactamases with direct carbapenem-hydrolyzing activity has contributed toward an increased prevalence of carbapenem-resistant enterobacteriaceae. Recent reports have described the spread of carbapenemase-producing Klebsiella pneumoniae across the world. There are very few existing agents that can be used against these pathogens and there are limited options on the horizon. In recent years, the epidemiology of bacterial strains involved in the pathogenesis of spontaneous bacterial peritonitis has also been changing rapidly. In this setting, we report the first case of nosocomial spontaneous bacterial peritonitis due to carbapenemase-producing K. pneumoniae.
Department of Medicine, Unit of Hepatic Emergencies and Liver Transplantation, University of Padova, Padova, Italy.
Salvatore
S
Piano
Antonietta
A
Romano
Silvia
S
Rosi
Angelo
A
Gatta
Paolo
P
Angeli
D015780:Carbapenems / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000175:diagnosis; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D005234:Fatty Liver / Q000150:complications*; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology*; D018440:beta-Lactam Resistance
D015780:Carbapenems