[Observation on effect of badu shengji san and its decomposed recipes on morphological changes of injured skin tissues in rats].
OBJECTIVE
To study the effect of Badu Shengji San (BDSJS) and its decomposed recipes on morphological changes of injured skin in rats.


METHODS
SD rats with injured skin were treated with BDSJS and its different decomposed recipes for consecutively 14 days. Morphological changes in the injured skin were observed by H&E staining.


RESULTS
Mercury and lead-containing ingredients significantly decreased epidermal thickness and caused vascular hemorrhage, hyperemia and inflammatory cell infiltration in reticular layer of dermis. The compatible herbs alleviated epidermal thickness and reduced dermal lesions.


CONCLUSIONS
BDSJS' mercury and lead-containing ingredients can accelerate the healing of skin wound and its compatible herbs can relieve the dermis injury induced by mercury and lead.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Rong
R
He
Bo
B
Peng
Yanli
Y
Lu
Jie
J
Gao
Lianqiang
L
Hui
Jianrong
J
Li
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004817:Epidermis / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced; D006940:Hyperemia / Q000139:chemically induced; D007854:Lead / Q000633:toxicity*; D008297:Male; D008628:Mercury / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D007854:Lead; D008628:Mercury