Refractory Salmonella enterica serotype choleraesuis-related renal cyst infection in a patient with autosomal dominant polycystic kidney disease undergoing hemodialysis treated successfully with intracystic ciprofloxacin infusion.
OBJECTIVE
To report a potential salvage therapy for refractory renal cyst infection secondary to Salmonellaenterica serotype choleraesuis (S. choleraesuis).


METHODS
A 52-year-old male with autosomal dominant polycystic kidney disease undergoing hemodialysis experienced an episode of S. choleraesuis-related gastroenteritis subsequently complicated by bloodstream and refractory renal cyst infection with formation of multiple pyocysts. The patient was treated with intracystic indwelling diluted ciprofloxacin solution.


CONCLUSIONS
In this patient, intracystic infusion of ciprofloxacin achieved a sufficient antibiotic level in infected renal cysts and hence completely eradicated S. choleraesuis. Therefore, intracystic antiobiotic infusion could be a potential salvage therapy for refractory renal cyst infection.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
Chih-Chao
CC
Yang
Feng-Rong
FR
Chuang
Chien-Hsing
CH
Wu
Jin-Bor
JB
Chen
Chih-Hsiung
CH
Lee
Chien-Te
CT
Lee
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003560:Cysts / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000628:therapy; D006435:Renal Dialysis; D012480:Salmonella Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D019779:Salmonella enterica / Q000302:isolation & purification*; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D002939:Ciprofloxacin