The involvement of the orbitofrontal cortex in psychiatric disorders: an update of neuroimaging findings.
OBJECTIVE
To report structural and functional neuroimaging studies exploring the potential role of the orbitofrontal cortex (OFC) in the pathophysiology of the most prevalent psychiatric disorders (PD).


METHODS
A non-systematic literature review was conducted by means of MEDLINE using the following terms as parameters: "orbitofrontal cortex", "schizophrenia", "bipolar disorder", "major depression", "anxiety disorders", "personality disorders" and "drug addiction". The electronic search was done up to July 2011.


CONCLUSIONS
Structural and functional OFC abnormalities have been reported in many PD, namely schizophrenia, mood disorders, anxiety disorders, personality disorders and drug addiction. Structural magnetic resonance imaging studies have reported reduced OFC volume in patients with schizophrenia, mood disorders, PTSD, panic disorder, cluster B personality disorders and drug addiction. Furthermore, functional magnetic resonance imaging studies using cognitive paradigms have shown impaired OFC activity in all PD listed above.


CONCLUSIONS
Neuroimaging studies have observed an important OFC involvement in a number of PD. However, future studies are clearly needed to characterize the specific role of OFC on each PD as well as understanding its role in both normal and pathological behavior, mood regulation and cognitive functioning.
Interdisciplinary Laboratory of Neurosciences, Universidade Federal de São Paulo, São Paulo, Brazil. andrea.jackowski@gmail.com
Andrea Parolin
AP
Jackowski
Gerardo Maria de
GM
Araújo Filho
Amanda Galvão de
AG
Almeida
Célia Maria de
CM
Araújo
Marília
M
Reis
Fabiana
F
Nery
Ilza Rosa
IR
Batista
Ivaldo
I
Silva
Acioly L T
AL
Lacerda
D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D001523:Mental Disorders / Q000473:pathology* / Q000503:physiopathology*; D059906:Neuroimaging