Peptide nanotube composed of cyclic tetra-β-peptide having polydiacetylene.
A cyclic tetra-β-peptide composed of three β-alanine residues and a L-β-homolysine residue having 10,12-pentacosadiynoic amide at the side chain was synthesized. The cyclic tetra-β-peptide formed peptide nanotubes in CDCl(3) . The diacetylene units along the peptide nanotubes were polymerized by UV irradiation to obtain peptide nanotubes with polydiacetylene along the nanotube. TEM and AFM observations of the polymerized cyclic tetra-β-peptides confirmed that the peptide nanotube structure was preserved after polymerization.
Department of Material Chemistry, Kyoto University, Kyoto, Japan.
Yusuke
Y
Ishihara
Shunsaku
S
Kimura
D008239:Lysine / Q000031:analogs & derivatives / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D045333:Nanotubes, Peptide / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D000078789:Polyacetylene Polymer; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*; D015091:beta-Alanine / Q000737:chemistry*
D045333:Nanotubes, Peptide; D010455:Peptides; D000078789:Polyacetylene Polymer; D011108:Polymers; D015091:beta-Alanine; D053279:Polyynes; C082361:polydiacetylene; D008239:Lysine