Iminosugar-ferrocene conjugates as potential anticancer agents.
We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.
Université de Reims Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR des Sciences Exactes et Naturelles, 51687 Reims Cedex 2, France.
Audrey
A
Hottin
Faustine
F
Dubar
Agata
A
Steenackers
Philippe
P
Delannoy
Christophe
C
Biot
Jean-Bernard
JB
Behr
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004354:Drug Screening Assays, Antitumor; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology; D050111:Imino Sugars / Q000737:chemistry* / Q000494:pharmacology; D007536:Isomerism; D000075163:Metallocenes; D011759:Pyrrolidines / Q000737:chemistry; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D050111:Imino Sugars; D000075163:Metallocenes; D011759:Pyrrolidines; D005644:alpha-L-Fucosidase; C004998:ferrocene