[The role of matrix metalloproteinases in pancreatic ductal adenocarcinoma].
Matrix metalloproteinases-7, -9 (MMP) are crucial factors for prognosis of pancreatic ductal adenocarcinoma (PDA). The expressions of MMP-2, 7, 9 increased in 60 patients with PDA and depended from stage of disease. Metastasis and invasive growth of tumor correlated with increase of MMP production and decrease of MMP inhibitors' expression, stimulated invasive growth of tumor.
S E
SE
Tsyganov
O V
OV
Paklina
G R
GR
Setdikova
A V
AV
Shabunin
V V
VV
Bedin
M M
MM
Tavobilov
P N
PN
Nikitin
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000201:enzymology* / Q000473:pathology; D017364:Collagenases / Q000096:biosynthesis*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000473:pathology
D009363:Neoplasm Proteins; D017364:Collagenases