Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles.
In recent years, there has been an increased interest in using nanoparticles for drug delivery and pharmaceutical development. Nanoparticles can offer significant advantages over the conventional drug delivery systems in terms of high drug loading, stability and specificity, controlled release capability, and the ability to deliver both hydrophilic and hydrophobic drug molecules through various routes of administration. This review article focuses on the use of the single emulsion solvent evaporation method, the first method proposed for the preparation of polymeric nanoparticles, and modifications that have been developed over the years to improve the results obtained with this technique.
Laboratorio de Investigacion y Posgrado en Tecnologia Farmaceutica, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico. Av 1 de Mayo s/n, Col. Santa Maria las Torres, Cuautitlan Izcalli, Estado de Mexico, 54740, Mexico. gpearz@hotmail.com
María G
MG
Nava-Arzaluz
Elizabeth
E
Piñón-Segundo
Adriana
A
Ganem-Rondero
David
D
Lechuga-Ballesteros
D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015195:Drug Design; D004355:Drug Stability; D004655:Emulsions; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
D003692:Delayed-Action Preparations; D004655:Emulsions; D004364:Pharmaceutical Preparations; D011108:Polymers; D012997:Solvents