[Comparison among conventional 4 L polyethylene glycol, split method of 4 L polyethylene glycol and combination of 2 L polyethylene glycol and sodium phosphate solution for colonoscopy preparation].
OBJECTIVE
The aim of this study was to compare polyethylene glycol (PEG) 4 L, split method of PEG 4 L and PEG 2 L plus sodium phosphate (NaP) in the aspect of bowel preparation quality, safety, patients' compliance and preference.


METHODS
Total 249 subjects were prospectively enrolled and received bowel preparation for colonoscopy from August to October in 2010; PEG 4 L (93 subjects), split method of 4 L PEG (74 subjects) and PEG 2 L plus NaP 90 mL group (82 subjects). To investigate the completion, preference for bowel preparation and safety, a questionnaire survey was conducted before colonoscopy.


RESULTS
There were no significant intergroup differences in the aspect of completion of preparation, cecal intubation time and success rate. Satisfaction and preference were higher in PEG 2 L plus NaP 90 mL and split method of 4 L PEG compared with PEG 4 L. In the aspect of the bowel preparation quality PEG 4 L showed significantly higher quality in the morning colonoscopy (p<0.001). However, in the afternoon colonoscopy PEG 2 L plus NaP 90 mL showed better result than PEG 4 L (p=0.009). Hyperphosphatemia was most frequently observed in PEG 2 L plus NaP 90 mL, but no severe adverse events occurred (p<0.001).


CONCLUSIONS
PEG 4 L showed better result than split method of 4 L PEG or PEG 2 L plus NaP 90 mL in the aspect of bowel preparation quality and safety.
Department of Internal Medicine, Seoul National University Bundang Hospital, 82, 173-gil, Gumi-ro, Bundang-gu, Seongnam 463-707, Korea.
So Young
SY
Jo
Nayoung
N
Kim
Jung Won
JW
Lee
Ji Hwan
JH
Lim
Chiun
C
Choi
Ilyoung
I
Chon
Ho
H
Kil
Bo Young
BY
Min
Young Sang
YS
Byoun
Ban Seok
BS
Lee
Sang Eon
SE
Jang
Hyun Kyung
HK
Park
Hyun Jin
HJ
Jo
Cheol Min
CM
Shin
Sang Hyup
SH
Lee
Young Soo
YS
Park
Jin-Hyeok
JH
Hwang
Jin-Wook
JW
Kim
Sook-Hyang
SH
Jeong
Dong Ho
DH
Lee
D000328:Adult; D000368:Aged; D002400:Cathartics / Q000009:adverse effects / Q000494:pharmacology*; D003106:Colon / Q000033:anatomy & histology / Q000187:drug effects*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010710:Phosphates / Q000009:adverse effects / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000494:pharmacology*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors
D002400:Cathartics; D010710:Phosphates; D011092:Polyethylene Glycols; C018279:sodium phosphate