Continuous flow photocatalysis enhanced using an aluminum mirror: rapid and selective synthesis of 2'-deoxy and 2',3'-dideoxynucleosides.
A unique photochemical flow reactor featuring quartz tubing, an aluminum mirror and temperature control has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2'-deoxy and 2',3'-dideoxynucleosides. The continuous flow format significantly increased the efficiency and selectivity of the reaction.
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA.
Bo
B
Shen
Matthew W
MW
Bedore
Adam
A
Sniady
Timothy F
TF
Jamison
D000535:Aluminum / Q000737:chemistry; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000295:instrumentation*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D004867:Equipment Design; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry*; D013997:Time Factors; D014466:Ultraviolet Rays
D002227:Carbazoles; D015224:Dideoxynucleosides; D017319:Photosensitizing Agents; D000535:Aluminum