The effect of overweight status on the short-term and 20-y outcomes after hepatic resection in patients with hepatocellular carcinoma.
BACKGROUND
We aimed to evaluate the impact of body mass index (BMI) on the short- and long-term outcomes of hepatic resection in patients with hepatocellular carcinoma (HCC).


METHODS
We performed 371 hepatic resections in HCC patients whom we categorized into two groups based on BMI: BMI ≥ 25 (n = 77) and BMI <25 (n = 294). We compared surgical outcomes between groups.


RESULTS
The incidence of postoperative complications in the BMI ≥ 25 group was comparable to those in the BMI <25 group. However, patients in the BMI <25 group showed a significantly worse long-term prognosis than those in the BMI ≥ 25 group (P < 0.01). The results of multivariate analyses showed that BMI <25 was an independent and prognostic indicator of long-term outcome after hepatic resection in HCC patients.


CONCLUSIONS
A BMI ≥ 25 is not a risk factor for mortality or postoperative complications, and is considered to provide a better long-term prognosis (>20 y) than a BMI <25 in patients with HCC after hepatic resection. Further studies are needed to determine whether these results apply to other patient populations outside Japan where BMI ≥ 30 is more prevalent.
Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan. itoshin@surg2.med.kyushu-u.ac.jp
Shinji
S
Itoh
Yasuharu
Y
Ikeda
Hirofumi
H
Kawanaka
Toshiro
T
Okuyama
Katsumi
K
Kawasaki
Daihiko
D
Eguchi
Daisuke
D
Korenaga
Kenji
K
Takenaka
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications*; D011183:Postoperative Complications / Q000453:epidemiology*