Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus.
A 5-year and 10-month old boy was diagnosed with classical type 1 diabetes mellitus (T1DM) without celiac disease. He started on a gluten-free diet after 2-3 week without need of insulin treatment. At the initiation of gluten-free diet, HbA1c was 7.8% and was stabilised at 5.8%-6.0% without insulin therapy. Fasting blood glucose was maintained at 4.0-5.0 mmol/l. At 16 months after diagnosis the fasting blood glucose was 4.1 mmol/l and after 20 months he is still without daily insulin therapy. There was no alteration in glutamic acid decarboxylase positivity. The gluten-free diet was safe and without side effects. The authors propose that the gluten-free diet has prolonged remission in this patient with T1DM and that further trials are indicated.
Paediatric Unit, Copenhagen University Hospital, Herlev, Denmark. stinesildorf@dadlnet.dk
Stine Møller
SM
Sildorf
Siri
S
Fredheim
Jannet
J
Svensson
Karsten
K
Buschard
D001786:Blood Glucose / Q000378:metabolism; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000178:diet therapy*; D055050:Diet, Gluten-Free; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D012074:Remission Induction
D001786:Blood Glucose; D006442:Glycated Hemoglobin