Haemodynamic responses to temperature changes of human skeletal muscle studied by laser-Doppler flowmetry.
Using a small, but very instructive experiment, it is demonstrated that laser-Doppler flowmetry (LDF) at large interoptode spacing represents a unique tool for new investigations of thermoregulatory processes modulating the blood flow of small muscle masses in humans. It is shown on five healthy subjects that steady-state values of blood flow (perfusion) in the thenar eminence muscle group depend in a complex manner on both the local intramuscular temperature and local skin temperature, while the values of blood flow parameters measured during physiological transients, such as the post-ischaemic hyperhaemic response, depend only on the intramuscular temperature. In addition, it is shown that the so-called biological zero (i.e. remaining LDF signal during arterial occlusion) is influenced not only as expected by the intramuscular temperature, but also by the skin temperature. The proposed results reveal that the skeletal muscle has unique thermoregulatory characteristics compared, for example, to human skin. These and other observations represent new findings and we hope that they will serve as a stimulus for the creation of new experimental protocols leading to better understanding of blood flow regulation.
Département de Neurosciences Fondamentales, University of Geneva, Geneva, Switzerland. tiziano.binzoni@unige.ch
Tiziano
T
Binzoni
David
D
Tchernin
Jonas
J
Richiardi
Dimitri
D
Van De Ville
Jean-Noël
JN
Hyacinthe
D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D006225:Hand / Q000000981:diagnostic imaging / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology*; D015424:Reperfusion; D013997:Time Factors; D014463:Ultrasonography