Sex-specific impact of prenatal stress on growth and reproductive parameters of guinea pigs.
Body condition and reproductive maturation are parameters of reproductive success that are influenced by sexual hormones rising in the circulation during the time of puberty. Various endocrine systems can be programmed by conditions experienced during early life. Stress for instance is supposed to be capable of influencing fetal development, leading to adjustments of offspring's later physiology. We examined whether prenatal stress (induced by exposure to strobe light) during early- to mid-gestation was capable of affecting later reproductive parameters in guinea pigs (Cavia aperea f. porcellus). Therefore, we measured the levels of testosterone and progesterone from the age of day 12-124 in prenatally stressed (PS, n = 20) and unaffected control animals (n = 24). Furthermore, we determined the timing of puberty and growth. Body weight development revealed significantly faster growth in PS females compared to control animals. The onset of first estrus was slightly earlier in PS females, however not significantly so. Cycle lengths and levels of progesterone differed between groups over the course of time with higher progesterone levels and more constant cycles among PS females compared to control females who displayed marked differences between first and subsequent cycles. Levels of testosterone did not differ between groups. We conclude that prenatal stress accelerates growth and maturity in females, but not in males.
Department of Integrative Biology and Evolution, Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Austria. Hanna.Schoepper@vetmeduni.ac.at
Hanna
H
Schöpper
Teresa
T
Klaus
Rupert
R
Palme
Thomas
T
Ruf
Susanne
S
Huber
D000818:Animals; D017849:Animals, Inbred Strains; D001522:Behavior, Animal; D030762:Estrous Cycle; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D008297:Male; D008425:Maternal Behavior; D010775:Photic Stimulation / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D011374:Progesterone / Q000097:blood; D012727:Sex Characteristics; D012741:Sexual Maturation; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood; D015430:Weight Gain
D013739:Testosterone; D011374:Progesterone