The marmoset monkey: a multi-purpose preclinical and translational model of human biology and disease.
The development of biologic molecules (monoclonal antibodies, cytokines, soluble receptors) as specific therapeutics for human disease creates a need for animal models in which safety and efficacy can be tested. Models in lower animal species are precluded when the reagents fail to recognize their targets, which is often the case in rats and mice. In this Feature article we will highlight the common marmoset, a small-bodied nonhuman primate (NHP), as a useful model in biomedical and preclinical translational research.
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands. hart@bprc.nl
Bert A
BA
't Hart
David H
DH
Abbott
Katsuki
K
Nakamura
Eberhard
E
Fuchs
D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D002144:Callithrix; D004195:Disease Models, Animal; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D013045:Species Specificity; D057170:Translational Research, Biomedical / Q000379:methods*
D007155:Immunologic Factors