[Study on herbal drugs of glycosides in brain].
Many active ingredients in traditional Chinese medicine exist in the form of glycosides. In recent years, the problem of low bioavailability of Chinese glycosides has caused wide public concern. Glycosides and their metabolites organization distribution directly affect glycosides' curative effect after different ways administration. With reports of glycosides medicine for prevention and treatment of brain diseases increasing, the research of glycosides brain tissue distribution is particularly important. According to reports, glycosides widely distributed in tissues, some glycosides can reach the brain, but some glycosides can not. This research reviews glycosides and their metabolites on the role of brain diseases, the distribution in the brain tissue and recent reports of dosage form's effect to brain. So it can provide a reference for the period of such medicine in the prevention and treatment of brain diseases and drug development.
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. lianzi87@126.com
Wei
W
Song
Weikui
W
Wu
Haiyan
H
Zhang
Ming
M
Yang
D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D001927:Brain Diseases / Q000188:drug therapy / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006027:Glycosides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D006027:Glycosides