Recent developments on the trifluoromethylation of (hetero)arenes.
Aryl-CF(3) as an extremely important family of fluorinated organic compounds holds wide applications in pharmaceuticals, agrochemicals, and advanced materials. Traditionally, such trifluoromethylated compounds have been synthesized from the corresponding aryl trichlorides via Cl exchange reactions (Scheme 1). This Focus review gives an overview over the recent development of trifluoromethylation of (hetero)arenes.
Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, 310018 People's Republic of China. xiao-feng.wu@catalysis.de
Xiao-Feng
XF
Wu
Helfried
H
Neumann
Matthias
M
Beller
D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry
D001897:Boronic Acids; D056831:Coordination Complexes; D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D011725:Pyridines; D010165:Palladium; D003300:Copper