Pentosidine, an advanced glycation end-product, may reflect clinical and morphological features of hand osteoarthritis.
The study investigates pentosidine levels, an advanced glycation end-product, in patients with erosive and non-erosive hand osteoarthritis (HOA) and determine its potential association with clinical findings and imaging-defined joint damage.Pentosidine was measured by HPLC in serum and urine of 53 females with HOA (31 erosive and 22 non-erosive HOA) and normalised to the total serum protein or urinary creatinine, respectively. Pain, joint stiffness and disability were assessed by the Australian/Canadian OA hand index (AUSCAN). The hand radiographs scored according to the Kallman grading scale were assessed to determine a baseline value and reassessed after two years.The levels of urine pentosidine, but not of serum pentosidine, were higher in patients with erosive HOA than in non-erosive HOA (p=0.039). Urinary pentosidine correlated with CRP (r=0.302, p=0.031), ESR (r=0.288, p=0.041) and AUSCAN (r=0.408, p=0.003). Serum pentosidine, but not in urine, significantly correlated with the Kallman radiographic score in erosive HOA at the baseline (r=0.409, p=0.022) and after 2 years (r=0.385, p=0.032). However, when corrected for age and disease duration, only correlation between urine pentosidine and AUSCAN remained significant (r=0.397, p=0.004).Our data suggest that serum and urine pentosidine levels may relate to the distinctive clinical and morphological features of HOA.
Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Martin
M
Braun
Hana
H
Hulejová
Jindřiška
J
Gatterová
Mária
M
Filková
Andrea
A
Pavelková
Olga
O
Sléglová
Nikola
N
Kaspříková
Jiří
J
Vencovský
Karel
K
Pavelka
Ladislav
L
Senolt