Oxidative stress and metal carcinogenesis.
Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.
Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Jeong-Chae
JC
Lee
Young-Ok
YO
Son
Poyil
P
Pratheeshkumar
Xianglin
X
Shi
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000378:metabolism; D004249:DNA Damage; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008670:Metals / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
D004785:Environmental Pollutants; D008670:Metals; D017382:Reactive Oxygen Species