Inhibition of gastrointestinal lipolysis by green tea, coffee, and gomchui (Ligularia fischeri) tea polyphenols during simulated digestion.
Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus making their beneficial effects doubtful. This study was conducted to evaluate the inhibitory effect of three beverages on lipolysis and the contribution of their major polyphenols during simulated digestion. During simulated digestion, gomchui tea was the most potent at inhibiting gastrointestinal lipolysis, whereas green tea was the least potent. The strongest lipase inhibitor among purified major polyphenols was a green tea polyphenol, (-)-epigallocatechin gallate (EGCG, IC(50) = 1.8 ± 0.57 μM), followed by di-O-caffeoylquinic acid isomers (DCQA, IC(50) from 12.7 ± 4.5 to 40.4 ± 2.3 μM), which are gomchui tea polyphenols. However, the stability of DCQA was greater than that of EGCG when subjected to simulated digestion. Taken together, gomchui tea, which has DCQA as the major polyphenol, showed stronger lipolysis inhibitory activity during simulated digestion compared to both green tea and coffee.
Functional Food Center, Korea Institute of Science and Technology (KIST), Gangneung 210-340, Republic of Korea.
Kwang Hyun
KH
Cha
Dae-Geun
DG
Song
Sang Min
SM
Kim
Cheol-Ho
CH
Pan
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001628:Beverages; D001682:Biological Availability; D003069:Coffee / Q000737:chemistry*; D004063:Digestion; D004791:Enzyme Inhibitors / Q000494:pharmacology; D041981:Gastrointestinal Tract / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D008049:Lipase / Q000037:antagonists & inhibitors*; D008066:Lipolysis / Q000187:drug effects; D010179:Pancreas / Q000201:enzymology; D059808:Polyphenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*
D019440:Anti-Obesity Agents; D003069:Coffee; D004791:Enzyme Inhibitors; D059808:Polyphenols; D013662:Tea; D008049:Lipase