Host responses in malaria disease evaluated through nuclear magnetic resonance-based metabonomics.
Malaria is a widespread disease caused by several species of Plasmodium. The parameters that render the hosts susceptible to severe disease complications are not completely understood. Nuclear magnetic resonance (NMR)–based studies offer a convenient platform to investigate the disease process in a noninvasive, nondestructive, and unbiased manner.NMR-based metabonomics allows a systems biological view of the global changes in host metabolism due to the parasite infection. Parasite-infected host red blood cells influence the neighboring uninfected host red blood cells metabolically. In the murine model of malaria, a sexually dimorphic host response is observed upon parasitic infection. Also the animals that are prone to cerebral malaria have different metabolic status vis-a-vis the ones that do not. Early prediction of susceptibility to cerebral malaria may be explored using such metabonomic methods.
Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai, Maharashtra, India.
Haripalsingh M
HM
Sonawat
Shobhona
S
Sharma
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005947:Glucose / Q000378:metabolism; D006790:Host-Parasite Interactions; D006801:Humans; D008288:Malaria / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D055432:Metabolomics / Q000379:methods; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010961:Plasmodium / Q000378:metabolism*
D005947:Glucose