Limb immobilization and corticobasal syndrome.
BACKGROUND
Recently, we evaluated two patients with corticobasal syndrome (CBS) who reported symptom onset after limb immobilization. Our objective was to investigate the association between trauma, immobilization and CBS.


METHODS
The charts of forty-four consecutive CBS patients seen in the Mayo Clinic Alzheimer Disease Research Center were reviewed with attention to trauma and limb immobilization.


RESULTS
10 CBS patients (23%) had immobilization or trauma on the most affected limb preceding the onset or acceleration of symptoms. The median age at onset was 61. Six patients manifested their first symptoms after immobilization from surgery or fracture with one after leg trauma. Four patients had pre-existing symptoms of limb dysfunction but significantly worsened after immobilization or surgery.


CONCLUSIONS
23 percent of patients had immobilization or trauma of the affected limb. This might have implications for management of CBS, for avoiding injury, limiting immobilization and increasing movement in the affected limb.
Department of Neurology, Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Jonathan
J
Graff-Radford
Bradley F
BF
Boeve
Daniel A
DA
Drubach
David S
DS
Knopman
J Eric
JE
Ahlskog
Erin C
EC
Golden
Dina I
DI
Drubach
Ronald C
RC
Petersen
Keith A
KA
Josephs
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology*; D001479:Basal Ganglia / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000150:complications* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D018450:Disease Progression; D005121:Extremities / Q000293:injuries; D005260:Female; D006801:Humans; D007103:Immobilization / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology; D013577:Syndrome; D024801:Tauopathies / Q000150:complications / Q000503:physiopathology; D014947:Wounds and Injuries / Q000150:complications* / Q000628:therapy