Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles.
An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields.
Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan, ROC. jchsieh@mail.tku.edu.tw
Jen-Chieh
JC
Hsieh
An-Yi
AY
Cheng
Jun-Hao
JH
Fu
Ting-Wei
TW
Kang
D000814:Aniline Compounds / Q000138:chemical synthesis; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D013141:Spiro Compounds / Q000138:chemical synthesis
D000814:Aniline Compounds; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C480174:coerulescine; C443722:horsfiline; C022960:2-oxindole; D003300:Copper