Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.
PPARγ activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells.
Department of Medicine; University of Colorado Denver; Aurora, CO USA.
Raphael
R
Nemenoff