On-chip digital microfluidic architectures for enhanced actuation and sensing.
An on-chip system is presented with integrated architectures for digital microfluidic actuation and sensing. Localized actuation is brought about by a digital microfluidic multiplexer layout that overcomes the challenges of multi-microdrop interference, and complete two-dimensional motion is shown for microdrops on a 14 × 14 grid with minimized complexity by way of 14+14 inputs. At the same time, microdrop sensing is demonstrated in a folded-cavity design for enhanced optical intensity probing of internal fluid refractive indices. The heightened intensities from this on-chip refractometer are shown to have a linear response to the underlying fluid refractive index. An electro-dispensing technique is used to fabricate the folded-cavity optical architecture in a format that is tuned for the desired refractive index range and sensitivity. The overall lab-on-a-chip system is successful in integrating localized microdrop actuation and sensing.
University of British Columbia, 3333 University Way, Kelowna, British Columbia, V1V1V7, Canada.
Jacqueline
J
Nichols
Christopher M
CM
Collier
Emily L
EL
Landry
Michael
M
Wiltshire
Brandon
B
Born
Jonathan F
JF
Holzman
D000818:Animals; D003198:Computer Simulation; D004566:Electrodes; D004867:Equipment Design; D005898:Glass / Q000737:chemistry; D006801:Humans; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D044085:Microfluidics / Q000379:methods*; D009038:Motion; D055095:Optics and Photonics; D011108:Polymers / Q000737:chemistry; D012031:Refractometry / Q000379:methods; D014867:Water / Q000737:chemistry
D011108:Polymers; D014867:Water