Mass Spectrometry Imaging: facts and perspectives from a non-mass spectrometrist point of view.
Mass Spectrometry Imaging (MSI, also called Imaging Mass Spectrometry) can be used to map molecules according to their chemical abundance and spatial distribution. This technique is not widely used in mass spectrometry circles and is barely known by other scientists. In this review, a brief overview of the mass spectrometer hardware used in MSI and some of the possible applications of this powerful technique are discussed. I intend to call attention to MSI uses from cell biology to histopathology for biological scientists who have little background in mass spectrometry. MSI facts and perspectives are presented from a non-mass spectrometrist point of view.
Laboratório de Bioquímica de Proteínas, Universidade Federal do Estado do Rio de Janeiro, Av. Pasteur, 296, Térreo, Urca, 22290-240 Rio de Janeiro, Brazil. cameron@unirio.br
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D000818:Animals; D003627:Data Interpretation, Statistical; D005583:Fourier Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D025341:Principal Component Analysis