[Coumarins from Skimmia arborescens and its anti-inflammatory effect].
To investigate chemical constituents contained in Skimmia arborescens. The chemical constituents were separated by silica gel column chromatography, pharmadex LH-20, RP-C18, and 1H, 13C-NMR spectroscopic analysis were employed for the structural elucidation. Six coumarin compounds were separated from S. arborescens. Their structures were elucidated as umbelliferone (1), scopoletin (2), scopolin (3), nodakenetin (4), skimmin (5), 6, 7-dimethoxycoumarin (6), and all compounds were separated from the plant for the first time. Using the model of ear swelling caused by xylol of mice, the anti-inflammatory effect of its total extract was evaluated. The result indicated that middle and high dose groups of its total extract could obviously inhibit the ear swelling caused by xylol of mice.
Natural Medicine Chemical Research Section, Yunnan Institute of Materia Medica, Kunming 650111, China. alen121@163.com
Lei
L
He
Shunli
S
Yang
Desong
D
Wu
Tao
T
Cui
Di
D
Wei
Zhongtao
Z
Ding
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004423:Ear / Q000473:pathology; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*; D058428:Silica Gel; D013047:Specific Pathogen-Free Organisms
D000893:Anti-Inflammatory Agents; D003374:Coumarins; D058428:Silica Gel