Egfl7 promotes tumor escape from immunity.
Egfl7 is an endothelial-specific gene which expression is deregulated in human cancers. We showed that Egfl7 promotes tumor escape from immunity by downregulating the expression of leukocyte adhesion molecules in endothelial cells, thus repressing immune cell extravasation into tumors.
CNRS UMR8161; Institut de Biologie de Lille; Lille, France.
Sébastien
S
Pinte
CNRS UMR8161; Institut de Biologie de Lille; Lille, France.
Fabrice
F
Soncin