A new butanolide compound from the aerial part of Lindera akoensis with anti-inflammatory activity.
A new butanolide, 3β-((E)-dodec-1-enyl)-4β-hydroxy-5β-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4α,5β)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC₅₀ values of 1.4-179.9 μM.
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
Chung-Ping
CP
Yang
Guan-Jhong
GJ
Huang
Hui-Chi
HC
Huang
Yu-Chang
YC
Chen
Chi-I
CI
Chang
Sheng-Yang
SY
Wang
Ih-Sheng
IS
Chen
Yen-Hsueh
YH
Tseng
Shih-Chang
SC
Chien
Yueh-Hsiung
YH
Kuo
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D027443:Lindera / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry*
C575318:3beta-((E)-dodec-1-enyl)-4beta-hydroxy-5beta-methyldihydrofuran-2-one; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D005663:Furans