Genome-wide analysis of human preimplantation aneuploidy.
An exciting era in preimplantation genetic diagnosis (PGD) is emerging with the adaptation and development of new high throughput genome-wide methodologies for the evaluation of aneuploidy. In fact, many promising preclinical studies and clinical trials involving comprehensive chromosome screening (CCS) have renewed clinician interest in the use of PGD for aneuploidy screening as an embryo selection tool to improve the success of in vitro fertilization (IVF). This review will provide an overview of the basic underlying features and applications of the growing number of platforms and strategies for preimplantation genome-wide analysis of aneuploidy.
Reproductive Medicine Associates of New Jersey, Morristown, New Jersey, USA. ntreff@rmanj.com
Nathan R
NR
Treff
D000782:Aneuploidy; D001757:Blastomeres; D055028:Comparative Genomic Hybridization / Q000379:methods*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D005820:Genetic Testing / Q000379:methods; D016678:Genome; D060005:Genotyping Techniques / Q000379:methods*; D006801:Humans; D021141:Nucleic Acid Amplification Techniques / Q000379:methods; D059705:Polar Bodies; D016133:Polymerase Chain Reaction / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*