A case of multiple brown tumors with primary hyperparathyroidism.
We report a case of large multiple brown tumors in a patient with primary hyperparathyroidism. A 52-year-old woman suffered from pain in the ribs and developed left facial swelling and deformity. CT showed a large destructive osteolytic lesion in the left maxillary sinus. Biopsy showed a lesion with newly formed bone tissue, diffuse giant cells and deposits of hemosiderin. In addition, similar lesions were also observed in the ribs, iliac bones and pelvis. The laboratory data showed hypercalcemia and hyperparathyroidism. Cervical echo and (201)Tl-(99m)TcO(4-) scintigraphy demonstrated a right lower swollen parathyroid adenoma. The diagnosis was multiple brown tumors with primary hyperparathyroidism and parathyroidectomy was performed. Follow-up CT showed marked decreases in the size of osteolytic lesions with calcification in the brown tumors compared to pre-treatment findings. These changes were associated with marked improvement in pain and facial deformity. We described a rare case of multiple brown tumors appeared in the maxilla associated with primary hyperparathyroidism.
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushyu, 807-8555, Japan.
Hiroko
H
Mori
Yosuke
Y
Okada
Tadashi
T
Arao
Shohei
S
Shimaziri
Yoshiya
Y
Tanaka
D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D005260:Female; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006961:Hyperparathyroidism / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D010282:Parathyroid Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D010858:Pigmentation
D006485:Hemosiderin