[Effective dose and time window of ginseng total saponins treatment in rat after traumatic brain injury].
OBJECTIVE
To investigate the neuroprotective effect, effective dose and time window of ginseng total saponins (GTS) treatment in rat after traumatic brain injury (TBI).


METHODS
The modified Feeney's method was used to establish TBI model in rat. GTS was treated intraperitoneally. The neurological function and histological morphology of brain tissue were observed.


RESULTS
Different doses of GTS were used 6 h after TBI. The neurological and histological results showed that: compared with the TBI group, significant efficacy was observed 2 - 14 days after injury with GTS treatment at 10, 20, 40, 60 and 80 mg/kg (P < 0.05); The effects of GTS at 20, 40, and 60 mg/kg were better than those of GTS at 10 and 80 mg/kg. During the research on the time window of GTS intervention, GTS (20 mg/kg) showed significant effect when used at 3 h and 6 h after TBI; however 12 h, 24 h after TBI, application of GTS did not exert any significant effect.


CONCLUSIONS
GTS intervention after TBI could reduce brain damage and promote recovery of the neurological function. Among doses of GTS 5 - 80 mg/kg, 20 - 60 mg/kg is the best dose limit. The effective time window of GTS is 6 h after TBI.
Institute of Nautical Medicine, Nantong University, Nantong 226001, China.
Bao-Ying
BY
Hu
Zheng-Lin
ZL
Jiang
Guo-Hua
GH
Wang
Xia
X
Li
Hong-Mei
HM
Shen
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D008297:Male; D018696:Neuroprotective Agents; D005894:Panax / Q000737:chemistry; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000008:administration & dosage* / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D012503:Saponins