Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications.
Micro- and nanotechnologies have emerged as potentially effective fabrication tools for addressing the challenges faced in tissue engineering and drug delivery. The ability to control and manipulate polymeric biomaterials at the micron and nanometre scale with these fabrication techniques has allowed for the creation of controlled cellular environments, engineering of functional tissues and development of better drug delivery systems. In tissue engineering, micro- and nanotechnologies have enabled the recapitulation of the micro- and nanoscale detail of the cell's environment through controlling the surface chemistry and topography of materials, generating 3D cellular scaffolds and regulating cell-cell interactions. Furthermore, these technologies have led to advances in high-throughput screening (HTS), enabling rapid and efficient discovery of a library of materials and screening of drugs that induce cell-specific responses. In drug delivery, controlling the size and geometry of drug carriers with micro- and nanotechnologies have allowed for the modulation of parametres such as bioavailability, pharmacodynamics and cell-specific targeting. In this review, we introduce recent developments in micro- and nanoscale engineering of polymeric biomaterials, with an emphasis on lithographic techniques, and present an overview of their applications in tissue engineering, HTS and drug delivery.
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hojae
H
Bae
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Hunghao
H
Chu
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Faramarz
F
Edalat
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jae Min
JM
Cha
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Shilpa
S
Sant
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.|Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology Zurich (ETH), 8092 Zurich, Switzerland.
Aditya
A
Kashyap
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Amir F
AF
Ahari
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chung Hoon
CH
Kwon
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jason W
JW
Nichol
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sam
S
Manoucheri
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Behnam
B
Zamanian
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Yadong
Y
Wang
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.|Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Ali
A
Khademhosseini
D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D057166:High-Throughput Screening Assays; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D001672:Biocompatible Materials