A novel role for granzymes in anti-tumor immunity.
The cytotoxic properties of granzymes are well established, though recent publications suggest additional roles for granzymes in immunity. We demonstrated that granzymes can act as regulators of cross-presentation by dendritic cells by inducing critical "eat-me" signals on the dying tumor cell, resulting in efficient phagocytosis of cell-associated tumor antigen.
Ludwig Maximilian University of Munich; Division of Clinical Pharmacology and Medical Clinic; Munich, Germany.
Sabine
S
Hoves
Vivien R
VR
Sutton
Joseph A
JA
Trapani