The healing effect of bioglue in articular cartilage defect of femoral condyle in experimental rabbit model.
BACKGROUND
The full-thickness articular cartilage defects of knee have a poor healing capacity that may progress to osteoarthritis and need a knee replacement. This study determines the healing effect of bioglue in fullthickness articular cartilage defect of femoral condyle in rabbit.


METHODS
Forty-eight male rabbits were randomly divided into four equal groups. In group A, 4 mm articular cartilage defects were created in the right and left medial femoral condyles. Then a graft from xiphoid cartilage was transferred into the defect together with a designed bioglue and the knees were closed. In group B, an articular cartilage defect was created identical to group A, but the defect size was 6 mm. In group C, 4 and 6 mm articular cartilage defects were created in the right and left medial femoral condyles respectively. The graft was transferred into the defect and the knees were stitched. In group D, articular cartilage defects were created similar to group C, just filled with bioglue and closed. The rabbits were euthanized and subgroups were defined as A1, B1, C1 and D1 after 30 days and A2, B2, C2 and D2 after 60 days. The cartilages were macroscopically and histologically investigated for any changes.


RESULTS
Microscopic and macroscopic investigations showed that bioglue had a significant healing effect in the femoral condyle.


CONCLUSIONS
Addition of bioglue can effectively promote the healing of articular cartilage defects.
Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran.
N
N
Tanideh
S
S
Dehghani Nazhvani
F
F
Mojtahed Jaberi
D
D
Mehrabani
S
S
Rezazadeh
S
S
Pakbaz
A
A
Tamadon
B
B
Nikahval