Immediate and long-term somatic effects, and health-related quality of life of BM donation during early childhood. A single-center report in 210 pediatric donors.
Since 1968, when Leiden undertook the first successful European pediatric BM transplantation with a 7-year-old sibling donor, more than 300 young children have donated BM in our unit. We first retrospectively studied a cohort of 210 donors, younger than 13 years at donation, to survey procedures of donor eligibility and study immediate effects of BM donation. We then performed a long-term follow-up (FU) and health-related quality of life (HRQoL) study. Despite documentation of previous medical conditions, no child was declared unfit to donate. We found that iron deficiency anemia or low-iron stores in BM did not result in treatment or extended FU. Harvest volumes exceeded 15 mL/kg in 65% of donors, with more than half requiring allogeneic blood transfusions. Donors had no structured FU after their first post-donation control. In this study, 25% of donors reported at least one somatic complaint at long-term FU. Finally long-term HRQoL revealed high scores in most subdomains (representing a higher QoL), compared to norm groups. These results indicate the need for development of (inter)national guidelines for pediatric stem cell donor care management.
Department of Pediatric SCT, Leiden University Medical Centre, Leiden, The Netherlands. walraven@europdonor.nl
S M
SM
van Walraven
L M
LM
Straathof
G E
GE
Switzer
A
A
Lankester
E T
ET
Korthof
A
A
Brand
L M
LM
Ball
D018798:Anemia, Iron-Deficiency / Q000209:etiology / Q000517:prevention & control / Q000523:psychology / Q000628:therapy; D001803:Blood Transfusion / Q000523:psychology; D001854:Bone Marrow Cells / Q000166:cytology* / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D015331:Cohort Studies; D033001:Directed Tissue Donation; D046148:Donor Selection; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008499:Medical Records; D009426:Netherlands; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D002666:Psychology, Child; D011788:Quality of Life; D012189:Retrospective Studies; D035781:Siblings; D014019:Tissue Donors / Q000523:psychology*; D065227:Transfusion Reaction