In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography.
Conventional imaging modalities are unable to depict the early degeneration of articular cartilage in osteoarthritis, especially in small joints. Optical coherence tomography has previously been used successfully in high-resolution imaging of cartilage tissue. This pilot cadaver study demonstrates the use of intra-articular optical coherence tomography in imaging of articular cartilage of the first carpometacarpal joint, producing high resolution images of the articular surface in which cartilage thickness and surface characteristics were assessed. Findings on optical coherence tomography were confirmed with histology. Furthermore, co-registration of optical coherence tomography and computed tomography was used to accurately determine the scanned trajectory and reconstruct a true-scale image overlay.
Paul
P
Cernohorsky
Daniel M
DM
de Bruin
Marcel
M
van Herk
Johannes
J
Bras
Dirk J
DJ
Faber
Simon D
SD
Strackee
Ton G
TG
van Leeuwen
D002102:Cadaver; D052737:Carpometacarpal Joints / Q000473:pathology*; D002356:Cartilage / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology*; D003661:Decision Support Techniques; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D010003:Osteoarthritis / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014953:Wrist