Anticoagulation for the treatment of thrombotic complications in patients with cirrhosis.
Cirrhotic patients can develop thrombotic complications, which in this group of patients occur with a greater frequency than in the general population. Portal vein thrombosis (PVT) is the most common thrombotic phenomenon, although deep venous thrombosis and pulmonary embolism can also occur. Risk factors for thrombosis include inherited and acquired deficiency of factors involved in anticoagulation mechanisms, venous stasis of the portal vein owing to architectural derangement of the liver and possibly local factors related to the endothelium. Clinical manifestations of PVT range from asymptomatic disease to a life-threatening complication, and although it is no longer considered an absolute contraindication for liver transplant, its presence may require challenging surgical techniques, which entail greater morbidity. Anticoagulation therapy is henceforth an important strategy to treat cirrhotic patients with PVT, although experience in this group of patients is limited. Vitamin K antagonists and low-molecular-weight heparin have been used successfully, achieving recanalization of the thrombosed vessel in patients with cirrhosis; however, the precise drug regimen management and monitoring has not be fully explored in this group of patients.
Multivisceral Transplant Unit, Department of Surgical, Oncological, and Gastroenterological Sciences, Padua University Hospital, Padua, Italy.
Kryssia I
KI
Rodriguez-Castro
Paolo
P
Simioni
Patrizia
P
Burra
Marco
M
Senzolo
D000925:Anticoagulants / Q000627:therapeutic use*; D000075202:Contraindications; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications*; D016031:Liver Transplantation; D015995:Prevalence; D012307:Risk Factors; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology*; D014812:Vitamin K / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D014812:Vitamin K; D006493:Heparin