Proof of concept for claudin-targeted drug development.
Claudins (CLs) are a family of tetra-integral membrane proteins that are a key structural and functional component of tight junctions. CLs are overexpressed in some malignant tumors. Claudin-4 is highly expressed in the epithelial cells covering mucosal immune tissues. CLs may therefore be a potential target for improving drug absorption, treating cancer, and developing mucosal vaccine. Research using Clostridium perfringens enterotoxin has resulted in proofs of concept for CL-targeted drug development. A platform for the creation of CL binders, such as immunization of CL and preparation of CL proteins, is now beginning to be established.
Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Hidehiko
H
Suzuki
Masuo
M
Kondoh
Azusa
A
Takahashi
Kiyohito
K
Yagi
D000818:Animals; D057167:Claudins / Q000187:drug effects* / Q000378:metabolism; D015195:Drug Design; D004768:Enterotoxins / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009092:Mucous Membrane / Q000187:drug effects
D057167:Claudins; D004768:Enterotoxins; C035598:enterotoxin, Clostridium