Preoperative serum placenta growth factor level as a new marker for stage II or III colorectal cancer patients.
OBJECTIVE
We first reported in this study that serum placenta growth factor and carcinoembryonic antigen in combination were useful markers for selecting early-stage colorectal cancer patients. The aim of the present study was to determine whether serum placenta growth factor could provide carcinoembryonic antigen-independent prognostic information on patients undergoing curative surgery.


METHODS
Serum and tissue samples were collected from 158 patients with colorectal cancer and from 50 controls. Serum and tissue levels of placenta growth factor were measured by enzyme-linked immunosorbent assay. The serum placenta growth factor levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum placenta growth factor levels and clinicopathological findings and survival.


RESULTS
Expression of placenta growth factor was significantly higher in colorectal cancer tissues compared with non-tumor tissues. The mean serum placenta growth factor level in patients was significantly higher than that in controls and significantly higher in patients with large tumor, lymph-node involvement and distant metastasis.


CONCLUSIONS
Elevated serum placenta growth factor levels are significantly associated with colorectal cancer development, lymph or distant invasive phenotypes and survival, especially in stage II or III patients.
Yüzüncü Yıl University, Department of General Surgery, Van, Turkey. ozgurkemik@hotmail.com
Ozgür
O
Kemık
Ahu
A
Sarbay Kemık
Aziz
A
Sümer
Sevim
S
Purısa
Barış
B
Tükenmez
Sefa
S
Tüzün
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002277:Carcinoma / Q000097:blood* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood*; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor