[Morpho-functional changes of rat ileum in ethanol intoxication].
The effect of chronic alcohol intoxication of 2, 4 and 6 months' duration on the morpho-functional state of the ileum was studied in male rats (n = 36) using histological, morphometric and histochemical methods. The results show that alcohol intoxication for a period of 2 months induced the changes in the mucous membrane of the ileum which in the form of its hypertrophy accompanied by the increase of epitheliocyte mitotic activity and goblet cell number. The activity of succinate dehydrogenase in the enterocytes and muscular tunic myocytes of the ileum wall was increased. After 4 and 6 months the changes included the inhibition of enterocyte mitotic activity. By 6 months of the experiment marked atrophy of the mucous membrane was noted. Succinate dehydrogenase activity was decreased in all the structures studied.
L M
LM
Iakovleva
L A
LA
Lobovtseva
D000435:Alcoholic Intoxication / Q000201:enzymology / Q000473:pathology*; D000818:Animals; D020895:Enterocytes / Q000187:drug effects* / Q000201:enzymology; D000431:Ethanol / Q000008:administration & dosage; D007082:Ileum / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D000431:Ethanol; D013385:Succinate Dehydrogenase