Lighting the fat furnace without SFRP5.
WNT signaling plays a central role in the regulation of cellular growth and differentiation. In this issue of the JCI, Mori et al. link WNT signaling to the oxidative capacity of adipocytes during obesity. They show that secreted frizzled-related protein 5 is an extracellular matrix-residing protein that is highly induced during obesity and inhibits oxidative phosphorylation in a tissue-autonomous manner, possibly by sequestering WNT3a. These results implicate local WNT signaling as an attractive target for combating obesity.
Alexander
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Rauch
Susanne
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Mandrup
D048868:Adaptor Proteins, Signal Transducing; D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D005260:Female; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D000094742:Secreted Frizzled-Related Proteins
D048868:Adaptor Proteins, Signal Transducing; D036341:Intercellular Signaling Peptides and Proteins; C487972:Sfrp5 protein, mouse; D000094742:Secreted Frizzled-Related Proteins