Pathogenesis of porcine reproductive and respiratory syndrome virus.
Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.
Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, United States.
Ranjni J
RJ
Chand
Benjamin R
BR
Trible
Raymond R R
RR
Rowland
D000818:Animals; D057131:Immune Evasion; D019318:Porcine Reproductive and Respiratory Syndrome / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology / Q000472:pathogenicity*; D013552:Swine; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism
D037521:Virulence Factors