ModuLand plug-in for Cytoscape: determination of hierarchical layers of overlapping network modules and community centrality.
The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.


BACKGROUND
The plug-in and its user guide can be downloaded freely from: http://www.linkgroup.hu/modules.php.
Department of Medical Chemistry, Semmelweis University, Budapest 1444, Hungary.
Máté
M
Szalay-Beko
Robin
R
Palotai
Balázs
B
Szappanos
István A
IA
Kovács
Balázs
B
Papp
Péter
P
Csermely
D000465:Algorithms; D003116:Color; D019295:Computational Biology / Q000379:methods; D053858:Metabolic Networks and Pathways; D060066:Protein Interaction Maps; D011506:Proteins / Q000737:chemistry*; D012984:Software; D014584:User-Computer Interface
D011506:Proteins