[Comparative study on toxicity of Euphorbia before and after being prepared by vinegar].
OBJECTIVE
To study and compare the changes of toxicity of Euphorbia pekinensis, E. kansui and E. ebracteolata before and after being prepared by vinegar.


METHODS
Small intestinal accentuation of mice and peritoneal macrophage NO release experiments were assessed to investigate the changes of toxicity of the three Chinese Medicines of Euphorbia before and after being prepared.


RESULTS
E. pekinensis, E. kansui and E. ebracteolata and vinegar can obviously promot small intestinal accentuation and peritoneal macrophage NO release with the intensity of toxicity in the order of E. kansui > E. pekinensis > E. ebracteolata. After being prepared with vinegar, the toxicity of the three medicines decreased obviously compared to crude one.


CONCLUSIONS
E. pekinensis, E. kansui and E. ebracteolata can induce inflammation and accelerate enterokinesis. After being prepared with vinegar, the irritation on Euphorbia decreased obviously.
Pharmacology College of Nanjing University of Chinese Medicine, Nanjing 210029, China. qiuyunying990165@163.com
Yunying
Y
Qiu
Hongli
H
Yu
Hao
H
Wu
Fagen
F
Zhu
Wenting
W
Tao
Qiuxiang
Q
Xu
D019342:Acetic Acid / Q000737:chemistry*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity*; D028481:Euphorbia / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry / Q000633:toxicity; D018675:Toxicity Tests
D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D019342:Acetic Acid