A Romanian therapeutic approach to peripheral nerve injury.
The study of nerve regeneration and functional recovery of the injured peripheral nerves represents a worldwide subject of clinical and scientific research. Our team aimed to obtain the first guide for nerve regeneration, bioartificial and biodegradable, using exclusively Romanian resources and having the advantages of price and quality, over the imported nerve conduits already used in clinical practice. First steps of this project consisted in obtaining the prototype of nerve guide conduit and its' testing in vitro and in vivo. Tests of physicochemical characterization, FTIR (Fourier Transform Infrared) spectrometry, thermal analysis (differential calorimetry, thermo-gravimetry), electron microscopy, water absorption and enzymatic degradation of the obtained prototype were followed by in vivo testing. The first results, obtained on a group of Brown Norway rats who suffered experimental lesions of 1 cm at the level of left sciatic nerve, which have then been repaired using the Romanian conduit prototype, are favorable in terms of biocompatibility, biodegradable capacity and support of nerve regeneration.
Department of Plastic Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
I
I
Zegrea
Laura Ioana
LI
Chivu
Mădălina Georgiana
MG
Albu
D
D
Zamfirescu
R D
RD
Chivu
Daniela Adriana
DA
Ion
I
I
Lascăr
D000818:Animals; D003094:Collagen; D048091:Guided Tissue Regeneration / Q000379:methods*; D008854:Microscopy, Electron; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000628:therapy*; D051381:Rats; D011914:Rats, Inbred BN; D012383:Romania; D012584:Sciatic Nerve / Q000293:injuries* / Q000502:physiology; D054457:Tissue Scaffolds
D003094:Collagen