Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives.
Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.
Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, Cali, Colombia. braulio.insuasty@correounivalle.edu.co
Braulio
B
Insuasty
Angélica
A
García
Juan
J
Bueno
Jairo
J
Quiroga
Rodrigo
R
Abonia
Alejandro
A
Ortiz
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001381:Azepines; D011743:Pyrimidines