Resveratrol still has something to say about aging!
A votre Santé! The mechanism by which resveratrol, a hydroxystilbenoid polyphenol found in grapes and present in wine, exerts antiaging metabolic benefits has been uncovered. Chung and co-workers have found that it works by inhibiting cAMP phosphodiesterases, thus triggering a signaling cascade that leads to the possible activation of the mammalian enzyme sirtuin 1.
Univ. Bordeaux, Institut des Sciences Moléculaires & Institut Européen de Chimie et Biologie, Pessac, France. s.quideau@iecb.u-bordeaux.fr
Stéphane
S
Quideau
Denis
D
Deffieux
Laurent
L
Pouységu
D000375:Aging / Q000187:drug effects*; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D059808:Polyphenols / Q000494:pharmacology*; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects*; D056564:Sirtuin 1 / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology*; D027843:Vitis / Q000737:chemistry; D014920:Wine
D000975:Antioxidants; D059808:Polyphenols; D013267:Stilbenes; D056564:Sirtuin 1; D000077185:Resveratrol