Synthesis of α,γ-peptide hybrids by selective conversion of glutamic acid units.
The site-selective modification of small peptides at a glutamate residue allows the ready preparation of α,γ-hybrids. In this way, a single peptide can be transformed into a variety of hybrid derivatives. The process takes place under very mild conditions, and good global yields are obtained.
Instituto de Productos Naturales y Agrobiología CSIC, Avda. Astrofísico Fco. Sánchez 3, 38206-La Laguna, Tenerife, Spain.
Carlos J
CJ
Saavedra
Alicia
A
Boto
Rosendo
R
Hernández
D018698:Glutamic Acid / Q000737:chemistry*; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; D018698:Glutamic Acid