Catalytic enantioselective tert-aminocyclization by asymmetric binary acid catalysis (ABC): stereospecific 1,5-hydrogen transfer.
Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5-H transfer specifically and stereoselectively in tert-aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).
Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
Liujuan
L
Chen
Long
L
Zhang
Jian
J
Lv
Jin-Pei
JP
Cheng
Sanzhong
S
Luo