N-acetylcysteine use for amelioration of aminoglycoside-induced ototoxicity in dialysis patients.
Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.
Leonid
L
Feldman
Richard A
RA
Sherman
Joshua
J
Weissgarten
D000111:Acetylcysteine / Q000627:therapeutic use*; D000617:Aminoglycosides / Q000009:adverse effects*; D004427:Ear Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D006435:Renal Dialysis; D012307:Risk Factors
D000617:Aminoglycosides; D016166:Free Radical Scavengers; D000111:Acetylcysteine