[Possible aggravation of a Henoch Schoenlein purpura by isotretinoin].
We report on a 16 year old patient with a hemorrhagic bullous form of a Henoch-Schönlein purpura. The cause for the event could not be determined, but the patient recovered without complications. Since he had begun a therapy with isotretinoin due to an acne inversa 3 weeks before, a possible association between the event and the treatment could not be excluded, and the case was reported to Swissmedic. In the comment, we discuss the pharmacology of isotretinoin, drug-induced vasculitis, and its pathomechanisms. As a general reminder, the criteria for the causality assessment of adverse drug reactions as well as the reporting system of adverse drug reactions in Switzerland are discussed.
Abteilung für Klinische Pharmakologie und Toxikologie, Regionales Pharmacovigilance-Zentrum Basel, Universitätsspital Basel, Basel.
A
A
Derungs
K
K
Eberhardt
U
U
Heiniger
C
C
Rudin
Y B
YB
Brauchli Pernus
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000188:drug therapy; D054242:Emigrants and Immigrants; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D007868:Leg Dermatoses / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D013557:Switzerland; D014421:Turkey / Q000208:ethnology
D003879:Dermatologic Agents; D005938:Glucocorticoids; D015474:Isotretinoin