Severe obesity:  evidence for a deranged metabolic program in skeletal muscle?
Severe obesity is increasing at a disproportionate rate compared with milder grade obesity. Our research group has obtained evidence indicative of an "obesity metabolic program" in skeletal muscles of severely obese individuals, which may be determined genetically or epigenetically. We believe that this represents a paradigm shift in thinking about metabolic regulation in obesity.
Department of Kinesiology and Human Performance Laboratory, College of Health and Human Performance, East Carolina University, Greenville, NC 27858, USA. houmardj@ecu.edu
Joseph A
JA
Houmard
Walter J
WJ
Pories
G Lynis
GL
Dohm
D000818:Animals; D004041:Dietary Fats / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology; D009767:Obesity, Morbid / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D046509:Tissue Culture Techniques; D015431:Weight Loss
D004041:Dietary Fats