New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm.
To expand the optional laser wavelengths of photodynamic therapy (PDT) for port wine stain (PWS), the feasibility of applying a 457 nm laser to the PDT for infantile PWS was analyzed by mathematical simulation and was validated by clinical experiment. Singlet oxygen yield of 457 nm PDT or 532 nm PDT in an infantile PWS model and an adult PWS model was theoretically simulated. Fifteen PWS patients (14 infants and 1 adult) with 40 spots were treated with 457 nm (20 spots) and 532 nm (20 spots), respectively, in two PDT courses. Simulation results showed that under the same power density and irradiation time, singlet oxygen yield of 457 nm PDT and 532 nm PDT are similar in infantile PWS vessels. Yet, in adult PWS vessels, singlet oxygen yield of 457 nm PDT is lower than 532 nm PDT. Clinical outcomes showed that no statistic difference existed between 457 nm PDT and 532 nm PDT for infantile PWS. The result of this study suggested that 457 nm wavelength laser has the potential to be applied in PDT for infantile PWS.
Chinese People's Liberation Army General Hospital, Department of Laser Medicine, Beijing 100853, China.
Ying
Y
Wang
Zhaohui
Z
Zuo
Ying
Y
Gu
Naiyan
N
Huang
Rong
R
Chen
Buhong
B
Li
Haixia
H
Qiu
Jing
J
Zeng
Jianguo
J
Zhu
Jie
J
Liang
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D053685:Laser Therapy / Q000379:methods*; D008543:Melanins / Q000737:chemistry; D015233:Models, Statistical; D008962:Models, Theoretical; D055095:Optics and Photonics; D010100:Oxygen / Q000737:chemistry; D010778:Photochemotherapy / Q000379:methods*; D010789:Phototherapy / Q000379:methods; D019339:Port-Wine Stain / Q000532:radiotherapy*; D026082:Singlet Oxygen / Q000737:chemistry; D012867:Skin / Q000473:pathology
D006454:Hemoglobins; D008543:Melanins; D026082:Singlet Oxygen; D010100:Oxygen