Abnormal gut integrity is associated with reduced linear growth in rural Malawian children.
The aim of the present study was to investigate the relation of environmental enteropathy, as measured by the dual sugar absorption test, to linear growth faltering in 2- to 5-year-old Malawian children. Dietary quality, food insecurity, anthropometry, and site-specific sugar testing were measured in 418 children, and anthropometry was reassessed 3 months later. A linear regression model predicting linear growth was created. Better growth was associated with less urinary lactulose excretion, more clean water usage, not sleeping with animals, and no previous history of malnutrition. Eighty-seven percent of children studied demonstrated evidence of environmental enteropathy. In conclusion, abnormal gut integrity is associated with reduced linear growth in a population of rural African preschool-age children.
Department of Pediatrics, Washington University, St Louis, MO, USA.
Ariana J
AJ
Weisz
Micah J
MJ
Manary
Kevin
K
Stephenson
Sophia
S
Agapova
Faith G
FG
Manary
Chrissie
C
Thakwalakwa
Robert J
RJ
Shulman
Mark J
MJ
Manary
D000818:Animals; D001284:Atrophy; D002675:Child, Preschool; D019422:Dietary Sucrose / Q000652:urine; D060766:Drinking Water / Q000592:standards; D006128:Growth; D006130:Growth Disorders / Q000209:etiology* / Q000652:urine; D006801:Humans; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D007792:Lactulose / Q000652:urine; D016014:Linear Models; D008295:Malawi / Q000453:epidemiology; D044342:Malnutrition / Q000150:complications; D012424:Rural Population; D012890:Sleep
D019422:Dietary Sucrose; D060766:Drinking Water; D007792:Lactulose