Photodegradation of lipopolysaccharides and the inhibition of macrophage activation by anthraquinone-boronic acid hybrids.
Target-selective photodegradation of 3-deoxy-D-manno-2-octulopyranosonic acid (KDO) was achieved without additives and under neutral conditions using a designed anthraquinone-boronic acid hybrid and long wavelength UV light irradiation. The hybrid can photodegrade lipopolysaccharides (LPS) and inhibit macrophage activation induced by LPS.
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Daisuke
D
Takahashi
Takuya
T
Miura
Kazunobu
K
Toshima
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000276:immunology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D051379:Mice; D010782:Photolysis; D013400:Sugar Acids / Q000737:chemistry / Q000276:immunology; D014466:Ultraviolet Rays
D000880:Anthraquinones; D001897:Boronic Acids; D008070:Lipopolysaccharides; D013400:Sugar Acids; C052138:2,6-anhydro-3-deoxyoctonate