[Immune mechanisms in pathogenesis of chronic heart failure].
In the review the new information about a participation of immune mechanisms in a pathogenesis of a chronic heart failure (CHF) is presented. Significance of a bacterial endotoxin, as inductor of activation of immune system at CHF, and factors of a system inflammation in a pathogenesis of the disease, breaking balance of matrix metalloproteinases and tissue inhibitors of metalloproteinases system, leading to change of structure of an extracellular matrix of a myocardium, are discussed.
E N
EN
Egorova
M N
MN
Kalinkin
E S
ES
Mazur
D002908:Chronic Disease; D017364:Collagenases / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology* / Q000473:pathology; D006333:Heart Failure / Q000276:immunology* / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D019714:Tissue Inhibitor of Metalloproteinases / Q000276:immunology*
D004731:Endotoxins; D019714:Tissue Inhibitor of Metalloproteinases; D017364:Collagenases