Resurrecting DNAzymes as sequence-specific therapeutics.
In a mouse model of skin cancer, intratumoral injection of a sequence-specific mRNA-cleaving DNA enzyme caused potent inhibition of tumor growth and unusually benign pharmacodynamic profiles.
Department of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. jrossi@coh.org
John J
JJ
Rossi
D000818:Animals; D021881:DNA, Catalytic / Q000627:therapeutic use*; D006801:Humans; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics*; D012878:Skin Neoplasms / Q000188:drug therapy*
D021881:DNA, Catalytic; D016755:Proto-Oncogene Proteins c-jun