[Stroke-induced nosocomial pneumonia in the acute period of cerebral hemorrhage: clinical pathogenic and age-associated aspects].
The article presents the clinical features of stroke-induced nosocomial pneumonia and interleukin-1alpha level monitoring in serum and cerebrospinal fluid of 100 patients with cerebral hemorrhage on the 1st, 3rd and 10th day. The authors show that 66% of patients with cerebral hemorrhage develop nosocomial pneumonia since the end of 2nd up to 5th day of conservative hospital treatment, more frequently in the serious cases with high level of neurological deficiency. The most important risk factors of stroke-induced nosocomial pneumonia are chronic focal infection, diabetes mellitus, cardiac failure, smoking, obesity. Since the first day of stroke the interleukin-1alpha level both in serum and cerebrospinal fluid exceeds 25-30 times its content in healthy people and increases more in the presence of nosocomial pneumonia. Interleukin-1alpha level can serve as an early risk marker of lethal outcome in patients with cerebral hemorrhage.
G S
GS
Dzhulaĭ
O A
OA
Pogorel'tseva
T A
TA
Sliusar'
S A
SA
Vorob'ev
D000208:Acute Disease; D000367:Age Factors; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002543:Cerebral Hemorrhage / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology / Q000401:mortality; D003428:Cross Infection / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000382:microbiology / Q000401:mortality; D005260:Female; D006801:Humans; D053582:Interleukin-1alpha / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000382:microbiology / Q000401:mortality; D011237:Predictive Value of Tests; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology / Q000401:mortality
D015415:Biomarkers; D053582:Interleukin-1alpha