Adipocyte dysfunction and hypertension.
Obesity is increasingly a public health problem due to its high risk of developing insulin resistance, diabetes, atherosclerosis, hypertension, chronic kidney disease, and increased cardiovascular morbidity and mortality. In particular, the association of obesity and hypertension is well recognized; however, the underlying mechanisms are not fully understood. This article reviews recent advancements of cellular and molecular mechanisms by which adipocyte dysfunction and obesity contribute to hypertension through endocrine and paracrine effects of the adipose tissue-derived adipokines on the function of vascular endothelial cells, smooth muscle cells and macrophages.
Feinberg Cardiovascular Research Institute, Department of Medicine - Cardiology, Northwestern Univesity Feinberg School of Medicine Chicago, IL, USA.
Junlan
J
Zhou
Gangjian
G
Qin