Hollow fiber-based liquid-liquid-liquid micro-extraction with osmosis: I. Theoretical simulation and verification.
Osmosis in hollow fiber-based liquid-liquid-liquid micro-extraction (HF-LLLME) was validated and utilized to improve enrichment factor of extraction in this study. When donor phase (sample solution) with higher ion strength than acceptor phase (extraction phase) was used, osmosis was established from acceptor phase, through organic membrane to donor phase. The mass flux expression of analytes across the organic membrane was established based on the convective-diffusive kinetic model, and the kinetic process for HF-LLLME with osmosis was simulated. Simulation results indicated that osmosis from acceptor phase to donor phase can increase enrichment factor of HF-LLLME, accelerate extraction process, and even result in the distribution ratio of analytes between donor and acceptor phase exceeding their partition coefficient. This phenomenon was verified by the experimental data of extraction with six organic acids and four organic bases as the model analytes.
Department of Instrumentation and Analytical Chemistry, Key Laboratory of Separation Science for Analytical Chemistry of CAS, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Qian
Q
Wu
Dapeng
D
Wu
Xuhui
X
Geng
Zheng
Z
Shen
Yafeng
Y
Guan
D004058:Diffusion; D007700:Kinetics; D059627:Liquid Phase Microextraction; D008956:Models, Chemical; D009994:Osmolar Concentration; D009995:Osmosis