Bluues server: electrostatic properties of wild-type and mutated protein structures.
BACKGROUND
Electrostatic calculations are an important tool for deciphering many functional mechanisms in proteins. Generalized Born (GB) models offer a fast and convenient computational approximation over other implicit solvent-based electrostatic models. Here we present a novel GB-based web server, using the program Bluues, to calculate numerous electrostatic features including pKa-values and surface potentials. The output is organized allowing both experts and beginners to rapidly sift the data. A novel feature of the Bluues server is that it explicitly allows to find electrostatic differences between wild-type and mutant structures.


BACKGROUND
The Bluues server, examples and extensive help files are available for non-commercial use at URL: http://protein.bio.unipd.it/bluues/.
Department of Biology, University of Padova, Viale G. Colombo 3, 35131 Padova, Italy.
Ian
I
Walsh
Giovanni
G
Minervini
Alessandra
A
Corazza
Gennaro
G
Esposito
Silvio C E
SC
Tosatto
Federico
F
Fogolari
D020407:Internet; D007700:Kinetics; D050505:Mutant Proteins / Q000737:chemistry*; D017354:Point Mutation; D011506:Proteins / Q000737:chemistry*; D012984:Software; D055672:Static Electricity
D050505:Mutant Proteins; D011506:Proteins