The brain activity map project and the challenge of functional connectomics.
The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits. This technological challenge could prove to be an invaluable step toward understanding fundamental and pathological brain processes.
Materials Science Division, Lawrence Berkeley National Lab and Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
A Paul
AP
Alivisatos
Miyoung
M
Chun
George M
GM
Church
Ralph J
RJ
Greenspan
Michael L
ML
Roukes
Rafael
R
Yuste
D000200:Action Potentials / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology