Human coronavirus NL63 in hospitalized children with respiratory infection: a 2-year study from Chongqing, China.
Human coronavirus (HCoV) NL63, a newly discovered coronavirus, has been associated with acute lower respiratory tract infections (ALRTI). We detected HCoV-NL63 via reverse transcriptional PCR (RT-PCR) in eight out of 878 respiratory specimens freshly collected from hospitalized children with ALRTI between April 2006 and March 2008 in Childrens Hospital of Chongqing Medical University. Peak of HCoV-NL63 activity often appeared during the summer and autumn in Chongqing area.  All children with HCoV-NL63 infection were <1 year of age. The diagnosis included bronchial pneumonia, bronchitis, interstitial pneumonia and bronchiolitis.  All children recovered.
Division of Nephrology and Immunology, Childrens Hospital of Chongqing Medical University, Chongqing, China.
Chen
C
Xin
Zhang Zhi
ZZ
Yong
Li
L
Yan
Zhao Xiao
ZX
Dong
D002681:China / Q000453:epidemiology; D018352:Coronavirus Infections / Q000453:epidemiology / Q000821:virology*; D058957:Coronavirus NL63, Human / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000821:virology; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*
D012367:RNA, Viral