Red laser cyclophotocoagulation in the treatment of secondary glaucoma in eyes with uveal melanoma.
OBJECTIVE
To evaluate retrospectively the usefulness of the red diode and krypton laser for transscleral contact cyclophotocoagulation (CPC) in the treatment of secondary glaucoma in eyes with uveal melanoma.


METHODS
Twenty-seven eyes of 27 patients (mean age, 66 y; range, 33 to 85 y) with a uveal melanoma and secondary glaucoma were treated with a transscleral 670-nm diode (40 treatments) and 647-nm krypton (5 treatments) laser CPC; 25 eyes had been or were subsequently treated with brachytherapy. The energy used was 420 mW at the tip of the probe (exposure time, 10 s). Seventeen eyes were treated once, 6 eyes twice, and 4 eyes 3 to 6 times. The aim was to preserve vision in 21 patients and to relieve pain in 6 patients. Fourteen patients (52%) died during follow-up.


RESULTS
With ≥1 CPCs, the intraocular pressure decreased from a median of 40 mm Hg at baseline to 28 mm Hg at 12 months (n=18) and 23 mm Hg at 24 months (n=10). Hypotony developed in 6 eyes. Before CPC, 12 eyes had a best corrected visual acuity (BCVA) of 20/400 or better. At 12 months, 5 of 18 eyes had BCVA 20/400 or better, and at 24 months 4 of 10 eyes. Four eyes were removed. At the latest visit, 15 of 23 eyes had no light perception, but were preserved. All patients whose aim of treatment was to relieve pain achieved pain relief.


CONCLUSIONS
CPC lowered intraocular pressure and the number of medications needed for secondary glaucoma in eyes with uveal melanoma, also providing pain relief.
Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland.
Anni
A
Piirtola
Päivi
P
Puska
Tero
T
Kivelä
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002924:Ciliary Body / Q000601:surgery*; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017075:Laser Coagulation / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D008875:Middle Aged; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D014792:Visual Acuity / Q000502:physiology; D000098943:Uveal Melanoma