[Study on the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage].
OBJECTIVE
To study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage.


METHODS
Choose 34 confirmed pneumoconiosis patients as drug treatment group and complex treatment group, and 17 tested workers as control group. Collected the content of TGF-beta1 and P III P which in these three investigated groups.


RESULTS
Drug treatment group and complex treatment group of patients improved the clinical symptoms and lung function Compared with Pretreatment, the FVC, FEV1.0, FEV1.0/FVC, MVV was obviously higher than those before treatment (P < 0.05). Complex treatment group than in the drug treatment group increased more significantly (P < 0.05). The level of TGF-beta1 and P III P was reduced after complex treatment (P < 0.05). Moreover,the level of TGF-beta1 and P III P in these patients are lower than in those patients treated with tetrandrine combined with whole lung lavage (P < 0.05).


CONCLUSIONS
Tetrandrine combined with whole-lung lavage could significantly retard the development of pneumoconiosis by lessening the TGF-beta1 and P III P in serum.
The West China 4th Hospital of Sichuan University, Chengdu 610041, China.
Li-Jun
LJ
Peng
Qi-Shang
QS
Zhu
D000328:Adult; D044182:Benzylisoquinolines / Q000627:therapeutic use*; D018893:Bronchoalveolar Lavage; D024061:Collagen Type III / Q000097:blood; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000097:blood / Q000628:therapy*; D053773:Transforming Growth Factor beta1 / Q000097:blood; D016896:Treatment Outcome
D044182:Benzylisoquinolines; D024061:Collagen Type III; D053773:Transforming Growth Factor beta1; C009438:tetrandrine