Pleomorphic carcinoma of the breast with expression of macrophage markers: report of two cases.
Pleomorphic ductal carcinoma of the breast is a rare variant included in the morphological group of infiltrating ductal carcinoma. The pleomorphic carcinoma is composed predominantly of epithelial and multinucleated tumor giant cells. We report here two cases presenting a lesion composed microscopically of a proliferation of large pleomorphic cells with a predominance of multinucleated giant cells. These lesions were negative for estrogen receptor, progesterone receptor and Her2-neu (triple-negative phenotype). Basal markers (cytokeratin 5/6, cytokeratin 17 and epidermal growth factor receptor [EGFR]) were present, accompanied by the presence of histiocyte marker CD163 in most neoplastic giant cells. High-grade pleomorphic breast carcinomas with the triple-negative phenotype and expression of basal markers might be included in the basal subtype. This is the first report about the co-expression of macrophage marker CD163, with tumor (P53) or epithelial markers (CAM5.2), as indicated by double immunohistochemistry in pleomorphic ductal carcinoma of the breast.
Department of Pathology Section A, Hospital Complex of Navarra, Navarra Health System, Navarra, Spain. acordobi@cfnavarra.es
Alicia
A
Córdoba
Maria
M
Del Rosario Mercado
Francisco
F
Vicente
Maria
M
Ederra
Natalia
N
Torrea
David
D
Guerrero-Setas
D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D014408:Biomarkers, Tumor; C400901:CAM 5.2 antigen; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; D016159:Tumor Suppressor Protein p53; D007633:Keratins; C512478:EGFR protein, human; D066246:ErbB Receptors