Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer.
This review focuses on phase-shift perfluorocarbon nanoemulsions whose action depends on an ultrasound-triggered phase shift from a liquid to gas state. For drug-loaded perfluorocarbon nanoemulsions, microbubbles are formed under the action of tumor-directed ultrasound and drug is released locally into tumor volume in this process. This review covers in detail mechanisms involved in the droplet-to-bubble transition as well as mechanisms of ultrasound-mediated drug delivery.
Department of Bioengineering, University of Utah, Salt Lake City, UT, USA. natasha.rapoport@utah.edu
Natalya
N
Rapoport
D016503:Drug Delivery Systems / Q000379:methods*; D005466:Fluorocarbons / Q000627:therapeutic use*; D006801:Humans; D045423:Microbubbles; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D044367:Phase Transition; D014465:Ultrasonics
D005466:Fluorocarbons