Relation between C-reactive protein and impaired fasting glucose in obese subjects.
Chronic systemic inflammation, characterized by elevated levels of the acute phase proteins, such as C-reactive protein (CRP), plays an important role in the pathogenesis of glucose metabolic disturbances and diabetes. The aim of this study was to determine if the elevated levels of CRP are associated with impaired fasting glucose (IFG) in obese subjects. Healthy obese men and nonpregnant obese women were enrolled in a case-control study. Individuals with new diagnosis of IFG were considered as cases and compared with a control group without IFG. Elevated CRP was defined by high-sensitivity C-reactive protein (hsCRP) levels between 3.0 and 10.0 mg/L and new diagnosis of IFG by the presence of fasting plasma glucose levels of 100 to 126 mg/dL. A total of 74 subjects were allocated into the case group and compared with 74 subjects in the control group. Elevated hsCRP was identified in 61 (41.2 %) and 34 (23.0 %) individuals in the case and control groups, respectively (p < 0.001). The adjusted odds ratio used to assess the association between elevated hsCRP levels and IFG was 3.36; 95 % confidence interval was 1.66-6.79. In conclusion, the elevated hsCRP levels are associated with IFG in obese subjects.
Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas No. 100, Col. Los Ángeles, C.P. 34067, Durango, México.
Luis E
LE
Simental-Mendía
Brissia
B
Lazalde
Graciela
G
Zambrano-Galván
Luis
L
Simental-Saucedo
Elizabeth
E
Rábago-Sánchez
Martha
M
Rodríguez-Morán
Fernando
F
Guerrero-Romero
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005215:Fasting / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009765:Obesity / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D001786:Blood Glucose; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D005947:Glucose