Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts.
This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming processes, including retro-free, enantiodivergent, entropy-controlled, and cycle-specific organocatalysis. Special emphasis is placed on the key requirements to attain high selectivity and on functional switching by exploiting the structural flexibility of our organocatalysts.
Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, 2-24-26 Naka-cho, Koganei, Tokyo, Japan.
Yoshihiro
Y
Sohtome
Kazuo
K
Nagasawa
D002384:Catalysis; D019277:Entropy; D019791:Guanidine / Q000737:chemistry*; D006860:Hydrogen Bonding; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
D012997:Solvents; D013890:Thiourea; D019791:Guanidine