Functional brain activity within the medial and lateral portion of BA10 during a prospective memory task.
In this study we tested the gateway hypothesis of Broadmann area 10 (BA10). With a functional magnetic resonance imaging (fMRI) protocol we manipulated the saliency--stimulus-oriented (SO) attending--and the memory load--stimulus-independent (SI) attending--during a prospective memory (PM) task. We found a significant main effect of the SO manipulation within the medial BA10 and a significant interaction between SI attending and PM task within the left lateral BA10. Our results give experimental support to the gateway hypothesis.
Clinical and Behavioural Neurology Laboratory, IRCCS Fondazione Santa Lucia, Rome, Italy. f.barban@hsantalucia.it
Francesco
F
Barban
Giovanni Augusto
GA
Carlesimo
Emiliano
E
Macaluso
Carlo
C
Caltagirone
Alberto
A
Costa
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003463:Cues; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult