[Post-thymus transplant vitiligo in a child with Foxn1 deficiency].
BACKGROUND
Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma.


METHODS
A 3-year-old boy underwent thymus transplantation at the age of 9 months for Foxn1 deficiency. He had developed urticaria and autoimmune hypothyroidism after thymus grafting. On examination, he had universal non-scarring alopecia, nail changes (atrophy, partial onycholysis and longitudinal grooves) and leucoderma on both big toes.


CONCLUSIONS
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. The pathogenic hypotheses discussed were post-graft vitiligo and leucoderma induced by Foxn1 deficiency.
Clinique dermatologique, hôpital Civil, centre hospitalier universitaire de Strasbourg, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France. evelevy@hotmail.fr
E
E
Levy
B
B
Neven
N
N
Entz-Werle
B
B
Cribier
D
D
Lipsker
D000483:Alleles; D000505:Alopecia / Q000235:genetics; D002675:Child, Preschool; D005091:Exons / Q000235:genetics; D005500:Follow-Up Studies; D051858:Forkhead Transcription Factors / Q000172:deficiency* / Q000235:genetics*; D006580:Genetic Carrier Screening; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000601:surgery*; D007223:Infant; D008297:Male; D020125:Mutation, Missense / Q000235:genetics; D009264:Nails, Malformed / Q000235:genetics; D011183:Postoperative Complications / Q000235:genetics*; D013950:Thymus Gland / Q000637:transplantation*; D014820:Vitiligo / Q000235:genetics*
D051858:Forkhead Transcription Factors; C090140:Whn protein