Bartter syndrome and growth hormone deficiency: three cases.
BACKGROUND
Bartter syndrome is a rare autosomal recessive disorder characterized by hypokalemia, salt loss, and metabolic alkalosis. Short stature is one of the clinical manifestations in these children. Although polyuria, polydipsia, hypokalemia, and salt loss may be responsible for growth retardation, the exact pathogenesis of short stature in Bartter syndrome is not known.


METHODS
In this study, we present three children diagnosed as having Bartter syndrome with short stature and growth hormone (GH) deficiency. After recombinant human growth hormone therapy (rhGH), their growth velocities were improved.


CONCLUSIONS
These results indicate that GH deficiency may contribute to short stature in children with Bartter syndrome, and rhGH therapy would be an excellent adjunctive treatment for short children with this syndrome whose condition is resistant to conventional therapies in terms of growth.
Pediatric Nephrology, Gaziantep University, Gaziantep, Turkey. buyukcelikm66@yahoo.com.
Mithat
M
Buyukcelik
Pediatric Endocrinology, Gaziantep University, Gaziantep, Turkey.
Mehmet
M
Keskin
Pediatric Nephrology, Gaziantep University, Gaziantep, Turkey.
Beltinge Demircioglu
BD
Kilic
Pediatric Endocrinology, Gaziantep University, Gaziantep, Turkey.
Yilmaz
Y
Kor
Pediatric Nephrology, Gaziantep University, Gaziantep, Turkey.
Ayse
A
Balat
D001477:Bartter Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D001827:Body Height / Q000187:drug effects / Q000235:genetics*; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006130:Growth Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010641:Phenotype; D016896:Treatment Outcome
D015415:Biomarkers; D019382:Human Growth Hormone