In vitro 5-LOX inhibitory and antioxidant activities of extracts and compounds from the aerial parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm.
The aim of this study was to investigate the antioxidant and anti-inflammatory potentials of crude extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. and its isolated compounds. Separation and structure elucidation of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. were conducted using chromatographic and spectroscopic method. The antioxidant activities of the extracts in this study were determined by the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene bleaching assays meanwhile the anti-inflammatory activity was evaluated using the 5-lipoxygenase assay. Seven known compounds quercetin 3-O-glucoside (1), naringenin 7-O-glucoside (2), seneciphylline-O-glucoside (3), chrysoeriol (4), retrorsine (5), adonifiline (6) and 5,4'-di-O-methyl alpinumisoflavone (7) were isolated from ethanol extract of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. The ethanol and water extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. elicited potent antioxidant and anti-inflammatory properties. Amongst the isolated compounds quercetin 3-O-glucoside gave strong antioxidant activity and adonifiline strongly inhibited 5-lipoxygenase activity.
The University of Nottingham, Malaysia Campus.
Sumi
S
Wijaya
Khoo Teng
KT
Jin
Ting Kang
TK
Nee
Christophe
C
Wiart
D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D019659:Asteraceae / Q000737:chemistry*; D001713:Biphenyl Compounds; D005296:Ferrous Compounds; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D016859:Lipoxygenase Inhibitors / Q000737:chemistry*; D010851:Picrates; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D019207:beta Carotene
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005296:Ferrous Compounds; D005419:Flavonoids; D007783:Lactones; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D010936:Plant Extracts; D011763:Pyrrolizidine Alkaloids; C546218:adonifoline; D019207:beta Carotene; C016527:isoquercitrin; C020748:ferrous sulfate; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl