Cardiac adipose tissue: a new frontier for cardiac regeneration?
The human heart has limited regenerative capacity. We focused on cardiac adipose tissue as a source of progenitor cells and biological matrix material for salvaging injured myocardium. First, a population of human adult mesenchymal-like progenitors derived from cardiac adipose tissue, with inherent cardiac and endothelial cell potential, was identified and characterized. Next, a salvage strategy was tested, where a pericardial-derived, vascularized, adipose flap was used to cover oxygen-deprived myocardium in a porcine model. The fat flap reduced the myocardial scar size, in both acute and chronic infarcts. A human clinical trial to examine this novel intervention is currently underway.
ICREC, Heart Failure and Cardiac Regeneration, Research Program, Health Sciences Research Institute Germans Trias i Pujol, Cardiology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. abayes.germanstrias@gencat.cat
Antoni
A
Bayes-Genis
Carolina
C
Gálvez-Montón
Cristina
C
Prat-Vidal
Carolina
C
Soler-Botija
D000273:Adipose Tissue / Q000166:cytology / Q000502:physiology* / Q000637:transplantation*; D000818:Animals; D002478:Cells, Cultured; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000502:physiology; D013552:Swine