Harnessing growth factors to influence wound healing.
Cutaneous wound healing is a dynamic process with the ultimate goal of restoring skin integrity. On injury to the skin, inflammatory cells, endothelial cells, fibroblasts, and keratinocytes undergo changes in gene expression and phenotype, leading to cell proliferation, migration, and differentiation. Cytokines and growth factors play an essential role in initiating and directing the phases of wound healing. These signaling peptides are produced by a variety of cells and lead to a concerted effort to restore the skin barrier function.
Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Elizabeth
E
Kiwanuka
Johan
J
Junker
Elof
E
Eriksson
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D003646:Debridement / Q000379:methods; D017719:Diabetic Foot / Q000378:metabolism / Q000628:therapy; D016523:Foot Ulcer / Q000378:metabolism / Q000628:therapy; D015316:Genetic Therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012867:Skin / Q000293:injuries* / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000378:metabolism* / Q000628:therapy*
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D007378:Interleukins; D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins