Itch pathophysiology may differ among ethnic groups.
The prevalence of itch is higher in individuals with darker skin types. In this paper, we review the systems involved in the physiology of itch and how they may differ across the races. Current data point out that the differences may be explained by barrier function, mast cell physiology, and itch receptor polymorphisms.
Department of Dermatology and Venereology, Erasmus Medical Centre, Rotterdam, the Netherlands. e.hajdarbegovic@erasmusmc.nl
Enes
E
Hajdarbegovic
Hok Bing
HB
Thio
D006801:Humans; D008407:Mast Cells / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011537:Pruritus / Q000208:ethnology* / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D044469:Racial Groups; D011968:Receptors, Histamine / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology; D050916:TRPV Cation Channels / Q000502:physiology; D014870:Water Loss, Insensible / Q000502:physiology
D011968:Receptors, Histamine; D050916:TRPV Cation Channels