Association between visceral adiposity and colorectal polyps on CT colonography.
OBJECTIVE
The purpose of this article is to determine whether there is an association between visceral adiposity measured on CT colonography (CTC) and colorectal polyps.


METHODS
Patients who underwent CTC and same-day optical colonoscopy (n = 1186) were analyzed. Visceral adipose tissue volumes and volume percentages relative to total internal body volume were measured on slices in the L2-L3 regions on supine CTC scans with validated fully automated software. Student t test, odds ratio, logistic regression, and receiver operating characteristic analyses were performed.


RESULTS
For subjects with (n = 345) and without (n = 841) adenomatous polyps, the mean (± SD) volume percentages were 31.2% ± 10.8% and 28.2% ± 11.3%, respectively (p < 0.0001). For subjects with (n = 244) and without (n = 942) hyperplastic polyps, the volume percentages were 31.8% ± 10.7% and 28.3% ± 11.2%, respectively (p < 0.0001). Comparing the lowest and highest quintiles of volume percentage, the odds ratios for having at least one adenomatous polyp or hyperplastic polyp versus no polyp were 2.06 (95% CI, 1.36-3.13) and 1.71 (95% CI, 1.08-2.71), and the prevalence of having adenomatous polyps or hyperplastic polyps increased by 14% and 8%, respectively.


CONCLUSIONS
Subjects with higher visceral adiposity measurements on CTC have a greater risk for the presence of colonic polyps.
Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bldg. 10, Rm 1C224D MSC 1182, Bethesda, MD 20892-1182, USA.
Ronald M
RM
Summers
Jiamin
J
Liu
Daniel L
DL
Sussman
Andrew J
AJ
Dwyer
Bhavya
B
Rehani
Perry J
PJ
Pickhardt
J Richard
JR
Choi
Jianhua
J
Yao
D050154:Adiposity; D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D015897:Comorbidity; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D009929:Organ Size; D012372:ROC Curve