Mesoporous silica nanoparticles in nanotechnology.
Mesoporous silica nanoparticles (MSNs) are a versatile drug delivery system that can be used for loading of different guest molecules such as peptides, proteins, anticancer agents, and genetic material. MSNs are considered promising drug carriers due to their tuneable particle size, pore structure, and surface functionalization. Thus, MSNs provide opportunities for their effective application in a wide variety of fields. In the current review, we discuss both conventional and advanced MSNs synthesis methods, including their applications for drug delivery, gatekeepers, and biosensors. In addition, the research progress in biocompatibility, cytotoxicity, and internalization mechanisms is reported.
University of Greenwich, School of Science, Medway Campus, Chatham Maritime, Kent, UK. D.Douroumis@gre.ac.uk
Dennis
D
Douroumis
Ichioma
I
Onyesom
Mohammed
M
Maniruzzaman
John
J
Mitchell
D000818:Animals; D004337:Drug Carriers; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry*
D004337:Drug Carriers; D012822:Silicon Dioxide