Selectivity enhancement arising from interactions at the PI3K unique pocket.
Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
Yujeong
Y
Jeong
Junghyun
J
Lee
Yoonji
Y
Lee
Kyungrok
K
Ham
Sun
S
Choi
Sungwoo
S
Hong
D001665:Binding Sites; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D061986:MCF-7 Cells; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D051357:Cyclin-Dependent Kinase 2; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; D011725:Pyridines; C023666:pyridine