Developing intrathoracic sentinel lymph node mapping with near-infrared fluorescent imaging in non-small cell lung cancer.
With poor survival and high recurrence rates, early-stage lung cancer currently appears to be understaged or undertreated, or both. Although sentinel lymph node biopsy is standard for patients with breast cancer and melanoma, its success has been unreliable in non-small cell lung cancer. Sentinel lymph node biopsy might aid in the identification of lymph nodes at the greatest risk of metastasis and allow for more detailed analysis to select for patients who might benefit from adjuvant therapy. The early results in our recent clinical trial of patients with early-stage lung cancer have suggested that near-infrared imaging might offer a platform for reliable sentinel lymph node identification in these patients.
Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA, USA. dmgilmore@partners.org
Denis M
DM
Gilmore
Onkar V
OV
Khullar
Yolonda L
YL
Colson
D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary* / Q000628:therapy; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008163:Luminescent Measurements / Q000266:history / Q000295:instrumentation; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D025202:Molecular Diagnostic Techniques / Q000266:history / Q000295:instrumentation; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy; D019265:Spectroscopy, Near-Infrared / Q000266:history / Q000295:instrumentation; D014741:Video Recording