Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model.
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.
Department of Anesthesiology and Resuscitology, Okayama University Graduate school of Medicine, Dentistry and Pharmaceutical Sciences, Japan. smizob@cc.okayama-u.ac.jp
Satoshi
S
Mizobuchi
Yoshikazu
Y
Matsuoka
Norihiko
N
Obata
Ryuji
R
Kaku
Yoshitaro
Y
Itano
Naoto
N
Tomotsuka
Arata
A
Taniguchi
Hiroyuki
H
Nishie
Hirotaka
H
Kanzaki
Mamoru
M
Ouchida
Kiyoshi
K
Morita
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D005557:Formaldehyde; D007278:Injections, Spinal; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; D009025:Morpholines; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D005557:Formaldehyde; C077049:landiolol; D014508:Urea