Comparative activities of the S-enantiomer and racemic forms of equol on bone fragility in ovariectomized mice.
We compared the effects of the S-enantiomer and racemic forms of equol on bone using ovariectomized (OVX) mice. Femoral bone mineral density and bone strength decreased in the OVX mice, but not in OVX mice administered 0.5 mg/d S-equol. This, however, did not hold for racemic equol. Serum and urine S-equol concentrations were higher in the mice administered S-equol than in those administered racemic equol. These results suggest that the inhibitory effects of S-equol on bone fragility in OVX mice are greater than those of racemic equol.
Department of Nutritional Science, Tokyo University of Agriculture, Japan.
Yoshifumi
Y
Kimira
Shin-ichi
S
Katsumata
Kazuharu
K
Suzuki
Yoshiko
Y
Ishimi
Tomomi
T
Ueno
Shigeto
S
Uchiyama
Herman
H
Adlercreutz
Mariko
M
Uehara
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D060754:Equol / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D005269:Femur / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D051379:Mice; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D058866:Osteoporotic Fractures / Q000097:blood / Q000517:prevention & control* / Q000652:urine; D010052:Ovariectomy; D048789:Phytoestrogens / Q000008:administration & dosage* / Q000737:chemistry; D013237:Stereoisomerism
D048789:Phytoestrogens; D060754:Equol