Natural products locally modulators of the cellular response: therapeutic perspectives in skin burns.
Local cellular response plays a major role in restoring skin integrity, in burns with infectious complications, chronic fibrous sequelae, etc. For the study of wound-healing process, different experimental models of skin burn were developed. Mice, rats, rabbits and guinea pigs are the most used laboratory animals, kept under standard conditions of light, temperature, food and water (ad libitum). Commonly, by intramuscular injection, general anesthesia was induced with ketamine hydrochloride. Most times, skin burns were inflicted on the dorsal region of animals. Metal devices with different shapes and weights, heated in water at various temperatures were applied locally, for few seconds. The paper reports on 65 natural medicinal products recommended for the external and internal treatment of skin damages (first- or second-degree burns, various wounds, ulcerations). Some of them are traditionally used in the Romanian ethnopharmacology, supporting the wound-healing process mainly because of their epithelizing, astringent, emollient, demulcent, anti-inflammatory, antimicrobial, immunomodulatory and antioxidant properties.
Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. mogosanu@umfcv.ro
G D
GD
Mogoşanu
Florina Carmen
FC
Popescu
Cristina Jana
CJ
Busuioc
H
H
Pârvănescu
I
I
Lascăr
D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D002056:Burns / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051379:Mice; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D001688:Biological Products