[Possibilities of systemic radiotherapy with high-purity 89Sr chloride in the treatment of bone metastases].
OBJECTIVE
To study the efficiency of treatment via single administration of high-purity 89Sr chloride in the standard activity of 150 MBq for pain syndrome in patients with multiple bone metastases.


METHODS
The authors carried out clinical trials of high-purity 89Sr chloride used to treat 30 patients with multiple bone metastases from cancers at various sites. The results of treatment were analyzed in 30 patients with multiple bone metastases, who had received systemic radiation therapy with high-purity 89Sr chloride in the standard activity of 150 MBq. These were assessed using some indicators: the intensity of pain syndrome and the blood concentrations of hemoglobin, leukocytes, and platelets.


RESULTS
There was evidence for the use of high-purity 89Sr chloride in the therapy of patients with cancer at various sites with multiple bone metastases. The major indicators (pain syndrome, the blood concentrations of hemoglobin, leukocytes, and platelets) were compared before and after the treatment. These were also compared with those obtained with the use of usual 89Sr chloride.


CONCLUSIONS
The therapeutic action of high-purity 89Sr chloride is comparable with that of 89Sr chloride in the standard activity; moreover, the analgesic effect of high-purity 89Sr chloride is being significantly higher. It has less significant myelotoxic activity than usual 89Sr chloride. High-purity 89Sr chloride is an effective radiopharmaceutical agent and may be used for systemic radiotherapy in patients with multiple bone metastatic lesion.
D K
DK
Fomin
O B
OB
Tararukhina
A A
AA
Nazarov
D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010146:Pain / Q000209:etiology / Q000532:radiotherapy; D059408:Pain Management / Q000379:methods*; D010166:Palliative Care / Q000379:methods; D018579:Patient Selection; D011879:Radiotherapy Dosage; D013324:Strontium / Q000008:administration & dosage* / Q000009:adverse effects; D013326:Strontium Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
D013326:Strontium Radioisotopes; C025700:strontium chloride; D013324:Strontium