Proteasome and neurodegeneratıve diseases.
Proteasomal degradation of damaged proteins is involved in the pathogenesis of many neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, stroke, and amyotrophic lateral sclerosis. A malfunction of the proteasomal activity may be the result or the consequence of protein aggregation, which is a key process for most neurodegenerative diseases. Because of the widespread aspects of the proteasomal involvement in the progression of these diseases, many studies are focused on this research.
Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center (GEMHAM), Marmara University, Haydarpasa, Istanbul, Turkey.
Betul
B
Catalgol
Tilman
T
Grune
D000818:Animals; D006801:Humans; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000201:enzymology* / Q000473:pathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D020836:Protein Structure, Quaternary
D046988:Proteasome Endopeptidase Complex