Anti-proliferation effect of Hevea brasiliensis latex B-serum on human breast epithelial cells.
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that the latex whole B-serum and DBP sub-fraction exerted a specific anti-proliferation activity against cancer-origin cells MDA-MB231 but had little effect on non-cancer-origin cells. On the other hand, the anti-proliferative activity was diminished in the pre-heated B-serum fractions. With the low toxicity that the B-serum demonstrated previously in Brine Shrimp Lethality Test (BSLT), the present results suggest the potential use of the B-serum sub-fractions in cancer treatment.
Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Yang Kok
YK
Lee
Lam Kit
LK
Lay
Mansor Sharif
MS
Mahsufi
Teoh Siang
TS
Guan
Sunderasan
S
Elumalai
Ong Ming
OM
Thong
D000818:Animals; D001156:Artemia / Q000187:drug effects; D001940:Breast / Q000166:cytology / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004847:Epithelial Cells / Q000187:drug effects*; D005260:Female; D028482:Hevea / Q000737:chemistry*; D006801:Humans; D007840:Latex / Q000494:pharmacology* / Q000633:toxicity
D007840:Latex