Infiltrating CTLs are bothered by HLA-E on tumors.
We recently described the upregulation of HLA-E in ovarian and cervical cancers. Instead of interacting with natural killer cells, HLA-E appeared to inhibit intratumoral cytotoxic T lymphocytes (CTL) via the receptor CD94/NKG2A. Strikingly, the survival benefit of intraepithelial infiltrating CTL was lost in those cancers with high HLA-E expression.
Department of Obstetrics & Gynecology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands.
Marloes J M
MJ
Gooden
Thorbald
T
van Hall