[Characteristic of microglial activation of hippocampus in experimental epileptic rats].
To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.



Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.



OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.



Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
Department of Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, China. sunhongxjt@yahoo.cn
Hong
H
Sun
Hai-qin
HQ
Wu
Gui-lian
GL
Zhang
Shu-qin
SQ
Zhan
Ru
R
Zhang
Hu-qing
HQ
Wang
D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006624:Hippocampus / Q000166:cytology / Q000473:pathology; D008297:Male; D017628:Microglia / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000473:pathology*