Relationship of Medication Management Test-Revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV.
While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates of performance on one such measure (i.e., Medication Management Test-Revised; MMT-R) were examined in 448 HIV+ adults who were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics (e.g., education), hepatitis C co-infection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities. MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications for evaluation of HAND.
Children's Diagnostic & Treatment Center, 1401 South Federal Highway, Fort Lauderdale, FL, 33316, USA. d1patton@browardhealth.org
Doyle E
DE
Patton
Steven Paul
SP
Woods
Donald
D
Franklin
Jordan E
JE
Cattie
Robert K
RK
Heaton
Ann C
AC
Collier
Christina
C
Marra
David
D
Clifford
Benjamin
B
Gelman
Justin
J
McArthur
Susan
S
Morgello
David
D
Simpson
J Allen
JA
McCutchan
Igor
I
Grant
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D017678:Sex Distribution; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis; D055815:Young Adult
D044966:Anti-Retroviral Agents