Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats.
Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200 mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.
Protein Laboratory, Institute of Neuroscience and Pharmacology, Panum Institute, Blegdamsvej 3C, Building 24.2, Copenhagen DK-2200, Denmark. mellis@sund.ku.dk
Oksana
O
Dmytriyeva
Boris
B
Klementiev
Vladimir
V
Berezin
Elisabeth
E
Bock
D000818:Animals; D000831:Animals, Newborn; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D005865:Gestational Age; D007093:Imidazoles / Q000633:toxicity*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011247:Pregnancy; D011273:Pregnancy, Prolonged / Q000139:chemically induced*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects; D012919:Social Behavior
D005659:Fungicides, Industrial; D007093:Imidazoles; C045362:prochloraz