Daphnetin prevents chronic unpredictable stress-induced cognitive deficits.
Chronic exposure to stress hormones might impair cognitive functions such as learning and memory, which were associated with many mood disorders and neurodegenerative diseases. In this study, we aimed to screen for effective compounds to prevent cognitive deficits induced by chronic stress. Daphnetin was found to protect the cortical neurons against dexamethasone-induced reduction of cell viability in a dose-dependent manner in vitro. We further evaluated its effects on chronic unpredictable stress (CUS) mice in vivo. Two and 8 mg/kg administration of daphnetin could improve the performance of stress mice in Morris water maze tests and forced swimming tests. The results suggested that daphnetin might be a potent compound to treat cognitive deficits induced by CUS.
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Min-Jing
MJ
Liao
Lian-Feng
LF
Lin
Xing
X
Zhou
Xiao-Wen
XW
Zhou
Xiao
X
Xu
Xin
X
Cheng
Qin
Q
Gao
Huan-Min
HM
Luo
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000009:adverse effects / Q000037:antagonists & inhibitors; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D014468:Umbelliferones / Q000008:administration & dosage / Q000627:therapeutic use*
D005938:Glucocorticoids; D018696:Neuroprotective Agents; D014468:Umbelliferones; C039952:daphnetin