Maximal lipid oxidation during exercise: a target for individualizing endurance training in obesity and diabetes?
This review summarizes the rationale for personalized exercise training in obesity and diabetes, targeted at the level of maximal lipid oxidation as can be determined by exercise calorimetry. This measurement is reproducible and reflects muscles' ability to oxidize lipids. Targeted training at this level is well tolerated, increases the ability to oxidize lipids during exercise and improves body composition, lipid and inflammatory status, and glycated hemoglobin, thus representing a possible future strategy for exercise prescription in patients suffering from obesity and diabetes.
INSERM U1046 Physiologie et Médecine Exprimentale du Coeur et du Muscle, Université Montpellier 1, Université Montpellier 2, CHRU Montpellier, France. j-brun@chu-montpellier.fr
J F
JF
Brun
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D
Malatesta
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A
Sartorio
D002153:Calorimetry, Indirect; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy*; D015444:Exercise; D006801:Humans; D050356:Lipid Metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000628:therapy*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010807:Physical Endurance; D057285:Precision Medicine