Edible Myrciaria vexator fruits: bioactive phenolics for potential COPD therapy.
The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16).
Department of Biological Sciences, Lehman College, and The Graduate Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States.
Keyvan
K
Dastmalchi
Gema
G
Flores
Shi-Biao
SB
Wu
Chunhui
C
Ma
Abdoulaye J
AJ
Dabo
Kathleen
K
Whalen
Kurt A
KA
Reynertson
Robert F
RF
Foronjy
Jeanine M
JM
D Armiento
Edward J
EJ
Kennelly
D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004610:Ellagic Acid / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry; D006801:Humans; D013058:Mass Spectrometry; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D027822:Myrtaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy
D016166:Free Radical Scavengers; D010636:Phenols; D004610:Ellagic Acid; D020781:Matrix Metalloproteinase 1