Cellular interactions of a water-soluble supramolecular polymer complex of carbon nanotubes with human epithelial colorectal adenocarcinoma cells.
Water-soluble, PAX-loaded carbon nanotubes are fabricated by employing a synthetic polyampholyte, PDM. To investigate the suitability of the polyampholyte and the nanotubes as drug carriers, different cellular interactions such as the human epithelial Caco-2 cells viability, their effect on the cell growth, and the change in the transepithelial electrical resistance in Caco-2 cells are studied. The resulting complex is found to exhibit an effective anti-cancer effect against colon cancer cells and an increased the reduction of the electrical resistance in the Caco-2 cells when compared to the precursor PAX.
Department of Materials Science and Engineering, Gwangju Institute of Science and Technology-GIST, 1 Oryong-dong, Buk-gu, Gwangju 500-712, South Korea.
Yeonju
Y
Lee
Kurt E
KE
Geckeler
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002021:Buffers; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000494:pharmacology; D004339:Drug Compounding; D017097:Electric Impedance; D006801:Humans; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology*; D058105:Polymerization; D020112:Rhodamine 123; D012995:Solubility; D014867:Water
D000972:Antineoplastic Agents, Phytogenic; D002021:Buffers; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008689:Methacrylates; D037742:Nanotubes, Carbon; D014867:Water; C008384:methacrylic acid; D020112:Rhodamine 123; C049840:2-(dimethylamino)ethyl methacrylate; D017239:Paclitaxel