Methanol extract of Sanguisorba officinalis L. with cytotoxic activity             against PC3 human prostate cancer cells.
Sanguisorba officinalis is a natural plant that has been traditionally used             for the treatment of inflammatory and metabolic diseases. Several studies have             reported that its extracts exhibit anticancer, antioxidative and anti-lipid peroxidation             activities. However, the effects of this plant on human prostate cancer cells             have not yet been investigated. In the present study, we investigated the inhibitory             effects and underlying mechanisms of a methanol extract of Sanguisorba officinalis             (MESO) in PC3 human prostate cancer cells. MESO significantly decreased cell growth             and induced apoptosis through the intrinsic apoptosis pathway. MESO decreased             the expression levels of myeloid cell leukemia-1 (Mcl-1), a Bcl‑2‑like anti-apoptotic             protein that is highly expressed in various cancer cell lines. Expression levels             of the pro-apoptotic protein Bax were increased by MESO whereas those of Bak and             Bcl-xL were unchanged. In addition, MESO induced the oligomerization of Bax in             the mitochondrial outer membrane. These results suggest that MESO inhibits the             growth of prostate cancer cells and induces apoptotic cell death by the downregulation             of Mcl-1 protein expression and the oligomerization of Bax. Therefore, MESO has             potential as a drug candidate for the treatment of prostate cancer.
Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Eun-Sun
ES
Choi
Jun-Sung
JS
Kim
Ki-Han
KH
Kwon
Hyng-Seop
HS
Kim
Nam-Pyo
NP
Cho
Sung-Dae
SD
Cho
D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation; D006801:Humans; D008297:Male; D000432:Methanol / Q000737:chemistry*; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D031993:Sanguisorba / Q000737:chemistry*; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000378:metabolism; D051020:bcl-X Protein / Q000378:metabolism
D064549:Myeloid Cell Leukemia Sequence 1 Protein; D010936:Plant Extracts; D019253:Proto-Oncogene Proteins c-bcl-2; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051020:bcl-X Protein; D000432:Methanol