A molecular profile of T-cell exhaustion in cancer.
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in "exhausted" T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease.
Ludwig Center and Radiation Oncology; University of Lausanne; Lausanne, Switzerland.
Daniel E
DE
Speiser