Diffuse alveolar haemorrhage may be associated with intravitreal injection of bevacizumab in a patient with systemic risk factors.
The authors present a rare case where acute respiratory failure occurred after the intravitreal bevacizumab injection for a branch retinal vein occlusion. Chest CT scan showed ground-glass opacity in the bilateral lung fields. The finding of bronchoalveolar lavage fluid revealed alveolar haemorrhage. Corticosteroid therapy resulted in a rapid improvement of respiratory failure. This report suggests that intravitreal injection of bevacizumab may be associated with diffuse alveolar haemorrhage and acute lung injury.
Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
Ruriko
R
Seto
Hideto
H
Yamada
Hiroshi
H
Wada
Makoto
M
Osawa
Taishi
T
Nagao
Yasutaka
Y
Nakano
D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D000068258:Bevacizumab; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D058449:Intravitreal Injections; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D011650:Pulmonary Alveoli; D012170:Retinal Vein Occlusion / Q000188:drug therapy; D012307:Risk Factors
D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab