The influence of nanostructured materials on biointerfacial interactions.
Control over biointerfacial interactions in vitro and in vivo is the key to many biomedical applications: from cell culture and diagnostic tools to drug delivery, biomaterials and regenerative medicine. The increasing use of nanostructured materials is placing a greater demand on improving our understanding of how these new materials influence biointerfacial interactions, including protein adsorption and subsequent cellular responses. A range of nanoscale material properties influence these interactions, and material toxicity. The ability to manipulate both material nanochemistry and nanotopography remains challenging in its own right, however, a more in-depth knowledge of the subsequent biological responses to these new materials must occur simultaneously if they are ever to be affective in the clinic. We highlight some of the key technologies used for fabrication of nanostructured materials, examine how nanostructured materials influence the behavior of proteins and cells at surfaces and provide details of important analytical techniques used in this context.
Industrial Research Institute Swinburne, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.
Peter
P
Koegler
Andrew
A
Clayton
Helmut
H
Thissen
Gil Nonato C
GN
Santos
Peter
P
Kingshott
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D018929:Cell Culture Techniques; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods; D011506:Proteins / Q000378:metabolism; D044968:Regenerative Medicine / Q000379:methods
D001672:Biocompatible Materials; D011506:Proteins