Mirror image phage display--generating stable therapeutically and diagnostically active peptides with biotechnological means.
Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches.
ICS-6, Forschungszentrum Jülich, 52425 Jülich, Germany.
Na
N
Sun
Susanne Aileen
SA
Funke
Dieter
D
Willbold
D001709:Biotechnology / Q000379:methods*; D061505:Cell Surface Display Techniques / Q000379:methods*; D055808:Drug Discovery; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
D010455:Peptides; D010447:Peptide Hydrolases