Tiki casts a spell on Wnt.
Negative feedback is a widespread feature of signaling pathways. In an unexpected twist described in this issue, He and colleagues identify a membrane-tethered metalloprotease named Tiki that inhibits Wnt signaling by removing an essential eight-residue fragment from Wnt itself.
MRC's National Institute for Medical Research, London NW7 1AA, UK. jvincen@nimr.mrc.ac.uk
Jean-Paul
JP
Vincent
Tony
T
Magee