Difficulties and pitfalls in the laboratory diagnosis of bleeding disorders.
von Willebrand disease (VWD) is the most common inherited bleeding disorder, but variable severity and several classification types mean that diagnosis is often not straightforward. In many countries, the assays are not readily available and/or are not well standardized. The latest methods and the basis of VWD are discussed here, together with information from the international quality assessment programme (IEQAS). Factor XIII deficiency is a rare, but important bleeding disorder, which may be missed or diagnosed late. A discussion and update on this diagnosis is considered in the final section of our review.
University of Manchester and Manchester Blood Centre, Manchester, UK. paula.bolton-maggs@manchester.ac.uk
P H B
PH
Bolton-Maggs
E J
EJ
Favaloro
A
A
Hillarp
I
I
Jennings
H P
HP
Kohler
D019411:Clinical Laboratory Techniques / Q000592:standards*; D003094:Collagen; D005177:Factor XIII Deficiency / Q000175:diagnosis*; D006388:Hemagglutinins; D006467:Hemophilia A / Q000175:diagnosis; D006801:Humans; D010974:Platelet Aggregation; D011786:Quality Control; D012310:Ristocetin; D014842:von Willebrand Diseases / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000378:metabolism
D006388:Hemagglutinins; D014841:von Willebrand Factor; D012310:Ristocetin; D003094:Collagen