A framework of whole heart extracellular volume fraction estimation for low-dose cardiac CT images.
Cardiac CT (CCT) is widely available and has been validated for the detection of focal myocardial scar using a delayed enhancement technique in this paper. CCT, however, has not been previously evaluated for quantification of diffuse myocardial fibrosis. In our investigation, we sought to evaluate the potential of low-dose CCT for the measurement of myocardial whole heart extracellular volume (ECV) fraction. ECV is altered under conditions of increased myocardial fibrosis. A framework consisting of three main steps was proposed for CCT whole heart ECV estimation. First, a shape-constrained graph cut (GC) method was proposed for myocardium and blood pool segmentation on postcontrast image. Second, the symmetric demons deformable registration method was applied to register precontrast to postcontrast images. So the correspondences between the voxels from precontrast to postcontrast images were established. Finally, the whole heart ECV value was computed. The proposed method was tested on 20 clinical low-dose CCT datasets with precontrast and postcontrast images. The preliminary results demonstrated the feasibility and efficiency of the proposed method.
School of Electrical and Information Engineering, Soochow University, Jiangsu 215006, China. xjchen@suda.edu.cn
Xinjian
X
Chen
Marcelo S
MS
Nacif
Songtao
S
Liu
Christopher
C
Sibley
Ronald M
RM
Summers
David A
DA
Bluemke
Jianhua
J
Yao
D000368:Aged; D003935:Diagnostic Techniques, Cardiovascular; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D012044:Regression Analysis; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*