Reduced size of sebaceous gland and altered sebum lipid composition in mice lacking fatty acid binding protein 5 gene.
Fatty acid binding proteins (FABPs) are capable of binding long-chain FA and are involved in intracellular FA transport and signal transduction. In sebaceous glands, FABP5 is highly expressed in differentiated sebocytes; though, its function remains unclear. In this study, we examined the role of FABP5 in sebocytes using FABP5-deficient mice. The size of sebaceous glands was significantly reduced, while the sebum volume was increased with altered lipid composition in FABP5-deficient mice. However, no significant differences were discerned in the expression of proliferation or differentiation markers including Blimp1, c-myc, Ki67 and peroxisome proliferator-activated receptors (PPAR)γ between wild-type and FABP5-deficient sebaceous glands. The expression of cellular retinoic acid binding protein-2 (CRABP2) that is a competitor of FABP5 for RA signalling was increased in FABP5-deficient mice. These results suggest that FABP5 is involved in the regulation of sebaceous gland activity through modulation of cellular lipid signalling and/or metabolism in the sebocytes.
Tomoko
T
Sugawara
Kei
K
Nemoto
Yasuhiro
Y
Adachi
Nozomi
N
Yamano
Nobuko
N
Tokuda
Masahiko
M
Muto
Ryuhei
R
Okuyama
Shingo
S
Sakai
Yuji
Y
Owada
D000818:Animals; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D019394:Ki-67 Antigen / Q000378:metabolism; D008055:Lipids / Q000032:analysis*; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D000074462:Positive Regulatory Domain I-Binding Factor 1; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D012627:Sebaceous Glands / Q000378:metabolism* / Q000473:pathology*; D012629:Sebum / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
C082667:Fabp5 protein, mouse; D050556:Fatty Acid-Binding Proteins; D019394:Ki-67 Antigen; D008055:Lipids; D009363:Neoplasm Proteins; D047492:Peroxisome Proliferator-Activated Receptors; C513258:Prdm1 protein, mouse; D016271:Proto-Oncogene Proteins c-myc; D018168:Receptors, Retinoic Acid; D014157:Transcription Factors; C082928:retinoic acid binding protein II, cellular; D000074462:Positive Regulatory Domain I-Binding Factor 1