New insights of T cells in the pathogenesis of psoriasis.
Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully understood, there is ample evidence suggesting that the dysregulation of immune cells in the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we mainly focus on the pathogenic T cells and discuss how these T cells are activated and involved in the disease pathogenesis. Newly identified 'professional' IL-17-producing dermal γδ T cells and their potential role in psoriasis will also be included. Finally, we will briefly summarize the recent progress on the T cell and its related cytokine-targeted therapy for psoriasis treatment.
Department of Medicine and Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Yihua
Y
Cai
Chris
C
Fleming
Jun
J
Yan
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D049109:Cell Proliferation; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D015603:Keratinocytes / Q000276:immunology*; D058990:Molecular Targeted Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta