The effect of systemically administrated zoledronic acid on the osseointegration of dental implants.
OBJECTIVE
The aim of conducting this study was to evaluate the effect of zoledronic acid (ZA) on the new bone formation (NBF) after the insertion of a titanium dental implant, which is very popular treatment in dentistry.


METHODS
Twelve New Zealand white rabbits were used in this study. The rabbits were divided in two groups. ZA was systemically administered to the study group. Titanium implants were placed to the left and right tibias of the rabbits.


RESULTS
The data from the ZA group revealed a statistically significant increase in the bone mineral content and the bone mineral density. A non-decalcified histomorphometric examination conducted on the study group revealed a significant increase of NBF and bone-implant contact (BIC) at 2 and 4 weeks.


CONCLUSIONS
A single dose of systemic ZA administration increases the rate of NBF and augments the quality of the bone.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Selcuk University, Konya, Turkey.
M
M
Ayan
D
D
Dolanmaz
A
A
Mihmanlı
A
A
Ayan
M
M
Kürkçü
D015502:Absorptiometry, Photon / Q000379:methods; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003720:Densitometry / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011817:Rabbits; D011897:Random Allocation; D013977:Tibia / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D015921:Dental Implants; D003764:Dental Materials; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D014025:Titanium