Clinical heterogeneity of desmoplastic infantile ganglioglioma:  a case series and literature review.
Desmoplastic infantile gangliogliomas (DIG) are intracranial tumors described in 1987 as benign lesions of infancy. A literature review and the clinical course of 3 patients reported herein suggest that the initial description should be amended. Nearly 23% of DIG cases occur in children older than 24 months. Approximately 40% of DIG cases require additional medical, radiation, and/or further surgical intervention, and 15% of infants and children develop leptomeningeal spread or die from DIG. Such adverse outcomes, combined with the recognition that DIG represents a heterogeneous disease, underscore the need for an expanded biological and molecular investigation.
Cancer and Blood Diseases Institute, Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati OH 45229-3039, USA. trent.hummel@cchmc.org
Trent R
TR
Hummel
Lili
L
Miles
Francesco T
FT
Mangano
Blaise V
BV
Jones
James I
JI
Geller
D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D018303:Ganglioglioma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012196:Review Literature as Topic; D015173:Supratentorial Neoplasms / Q000473:pathology* / Q000628:therapy