Exercise training-induced regulation of mitochondrial quality.
Mitochondria are dynamic organelles in skeletal muscle critical in physical performance and disease. The mitochondrial life cycle spans biogenesis, maintenance, and clearance. Exercise training may promote each of these processes, conferring positive impacts on skeletal muscle contractile and metabolic functions. This review focuses on the regulation of these processes by endurance exercise and discusses potential benefits in health and disease.
Departments of Medicine and Pharmacology, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA. zhen.yan@virginia.edu
Zhen
Z
Yan
Vitor A
VA
Lira
Nicholas P
NP
Greene
D000818:Animals; D001343:Autophagy; D015444:Exercise; D006801:Humans; D008928:Mitochondria / Q000502:physiology*