Lycopene effects on serum mineral elements and bone strength in rats.
This study investigated the beneficial effect of lycopene on bone biomarkers in ovariectomized (OVX) rats. Female Wistar rats were either sham operated or surgically ovariectomized and then fed with lycopene for 8 weeks. Serum Ca, P, alkaline phosphatase (ALP), interleukin 6 (IL-6) and bone gla protein (BGP) concentration was significantly higher in the untreated OVX group compared with that of the sham group, whereas serum estrogen levels were lower. Bone mineral density (BMD), BMD/wt, bone mineral content (BMC), BMC/wt values, maximum load, stiffness, energy and maximum stress were significantly lower in the untreated OVX group compared with that of the sham group. Administration of lycopene (20, 30 and 40 mg/kg b.w.) for 8 weeks significantly decreased serum Ca, P, ALP, and IL-6 concentration, and enhanced serum estrogen level, BMD, BMD/wt, BMC, BMC/wt values, maximum load, stiffness, energy and maximum stress in lycopene-treated OVX groups. In conclusion, the consumption of lycopene may have the most protective effect on bone in OVX rats.
Hands and Feet Microsurgery, Dalian Municipal Central Hospital, Dalian 116033, China. lianghddlytt@sina.com
Haidong
H
Liang
Fang
F
Yu
Zhihong
Z
Tong
Weifeng
W
Zeng
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D015850:Interleukin-6 / Q000097:blood; D000077276:Lycopene; D008903:Minerals / Q000097:blood*; D015675:Osteocalcin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D015850:Interleukin-6; D008903:Minerals; D015675:Osteocalcin; D002338:Carotenoids; D000469:Alkaline Phosphatase; D000077276:Lycopene