Malignant transformation of bronchogenic cyst revealed by 99mTc-MIBI-SPECT.
Adenocarcinoma arising from a mediastinal cyst was detected by exercise technetium-99m hexakis-2-methoxyisobuty-lisonitrile (99m)Tc-MIBI scintigraphy in a 65-year-old woman with known coronary disease. This guided further investigations and resection of the tumor which stained positive for P-glycoprotein. Three years earlier, myocardial scintigraphy was negative, probably due to down-expression of P-glycoprotein because the cells were in the early stages of carcinogenesis. After completing malignant transformation, the high P-glycoprotein expression resulted in MIBI uptake on the second myocardial scintigraphy.
Thoracic Surgery Unit, Department of Pathology, Second University of Naples, Naples, Italy.
Alfonso
A
Fiorelli
Pierfrancesco
P
Rambaldi
Marina
M
Accardo
Mario
M
Santini
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D000230:Adenocarcinoma / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D001994:Bronchogenic Cyst / Q000000981:diagnostic imaging*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000601:surgery; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi