Acute tubular necrosis due to cutaneous contact with cresol.
The authors report a case of a 43-year-old woman who presented with second degree chemical burns to 9% of the total body surface area due to cutaneous contact with cresol. This was associated with acute oliguric kidney injury requiring haemodialysis. In contrast to previous reports of cresol ingestion, the patient did not have evidence of hepatic dysfunction, possibly due to a low cresol concentration in the portal vein and liver. Renal histopathology showed regional accentuated tubular necrosis and disruption of the tubular basement membrane. Renal toxicity was thought to be due to direct tubular toxicity and impaired renal blood flow.
Department of Nephrology, Immunology, and Vascular Medicine, Shonan Kamakura General Hospital, Kamakura, Japan. okamoto5-tky@umin.ac.jp
Koji
K
Okamoto
Eisei
E
Noiri
Machiko
M
Oka
Hidekazu
H
Moriya
Takayasu
T
Ohtake
Shuzo
S
Kobayashi
D000328:Adult; D002057:Burns, Chemical / Q000209:etiology*; D003408:Cresols / Q000633:toxicity*; D005260:Female; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D012867:Skin / Q000293:injuries*
D003408:Cresols; C077977:cresol