CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms.
The distinction of CLL from other mature B-cell neoplasms, especially from leukemic forms of mantle cell lymphoma or splenic marginal zone lymphoma, can be difficult but has important prognostic and therapeutic implications. We measured CLLU1 (CLL upregulated gene1) mRNA by qPCR and found a highly significant difference between CLL and other lymphoid neoplasms (AUC 0.96, 95%CI 0.93-0.99). Based on our cut-off values we can predict CLL and other mature B-cell neoplasms with high probability (PPV 99% and 94%). Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.
Department of Hematology, University Hospital and University of Bern, Bern, Switzerland. elisabeth.oppliger@insel.ch
Elisabeth
E
Oppliger Leibundgut
Daniela
D
Rogenmoser-Dissler
Dirk
D
de Beer
Naomi A
NA
Porret
Silvia
S
Zibellini
Jan
J
Dürig
Alexander
A
Röth
Dirk
D
Klingbiel
Gabriela M
GM
Baerlocher
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002454:Cell Differentiation / Q000235:genetics; D003937:Diagnosis, Differential; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D016130:Immunophenotyping; D015448:Leukemia, B-Cell / Q000175:diagnosis* / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding; D012189:Retrospective Studies; D015854:Up-Regulation / Q000235:genetics
D014408:Biomarkers, Tumor; C510032:CLLU1 lncRNA, human; D009363:Neoplasm Proteins; D062085:RNA, Long Noncoding