Solid-phase synthesis of γ-AApeptides using a submonomeric approach.
The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.
Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
Haifan
H
Wu
Mohamad Nassir
MN
Amin
Youhong
Y
Niu
Qiao
Q
Qiao
Nassier
N
Harfouch
Abdelfattah
A
Nimer
Jianfeng
J
Cai
D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides