Six new chalcones from Angelica keiskei inducing adiponectin production in 3T3-L1 adipocytes.
Angelica keiskei (Ashitaba in Japanese), a traditional herb in Japan, contains abundant prenylated chalcones. It has been reported that the chalcones from A. keiskei showed such bioactivities as anti-bacterial, anti-cancer and anti-diabetic effects. Xanthoangelol, 4-hydroxyderricin and six new chalcones were isolated in this study from an ethanol extract of A. keiskei by octadecyl silyl (ODS) and silica gel chromatography, and identified by 1D- and 2D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometric analyses. The chalcones from A. keiskei markedly increased the expression of the adiponectin gene and the production of adiponectin in 3T3-L1 adipocytes. These results suggest that the chalcones from A. keiskei might be useful for preventing the metabolic syndrome.
Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan. onogih@takara-bi.co.jp
Hiromu
H
Ohnogi
Yoko
Y
Kudo
Kenichi
K
Tahara
Katsumi
K
Sugiyama
Tatsuji
T
Enoki
Shoko
S
Hayami
Hiroaki
H
Sagawa
Yuko
Y
Tanimura
Wataru
W
Aoi
Yuji
Y
Naito
Ikunoshin
I
Kato
Toshikazu
T
Yoshikawa
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D052242:Adiponectin / Q000096:biosynthesis* / Q000235:genetics; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D000431:Ethanol / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D018517:Plant Roots / Q000737:chemistry*
D052242:Adiponectin; D007004:Hypoglycemic Agents; D000431:Ethanol; C068243:4-hydroxyderricin; D002599:Chalcone; C068244:xanthoangelol