Wnt signaling and injury repair.
Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway plays in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California 94305, USA.
Jemima L
JL
Whyte
Andrew A
AA
Smith
Jill A
JA
Helms
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008954:Models, Biological; D012038:Regeneration / Q000502:physiology*; D013045:Species Specificity; D060449:Wnt Signaling Pathway / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*