Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development.
Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated "senescence surveillance," restricts liver cancer development.
Helmholtz Centre for Infection Research; Braunschweig, Germany ; Hannover Medical School; Department of Gastroenterology, Hepatology and Endocrinology; Hannover, Germany.
Tetyana
T
Yevsa
Tae-Won
TW
Kang
Lars
L
Zender