Imaging of highly malignant osteosarcoma with iodine-123-vascular endothelial growth factor.
OBJECTIVE
Vascular endothelial growth factor (VEGF) is an important angiogenic factor, and its receptors have been shown to be overexpressed in various human carcinomas. In this study, we investigated the role of scanning with iodine-123 ((123)I)-labelled VEGF(165) in patients with highly malignant osteosarcoma.


METHODS
Two patients (a 15-year-old female and a 14-year-old male) with osteosarcoma were injected with 140 MBq [<130 pmol (<5 µg) VEGF(165) per patient] of (123)I-VEGF(165). Dynamic acquisition was initiated immediately after administration and carried out until 30 min after injection. Whole-body images were done in anterior and posterior views at various time points. All patients underwent single-photon emission tomography imaging.


RESULTS
(123)I-VEGF(165) scans were positive in these patients. Sequential images clearly showed increased (123)I-VEGF(165) activity in osteosarcoma lesions. The tumour lesions were still visualized in whole-body images and single-photon emission tomography examinations 2 h after injection. Intravenous injection of (123)I-VEGF(165) did not cause any side effects.


CONCLUSIONS
Our results suggest that (123)I-VEGF(165) receptor scintigraphy may be useful for the visualization of highly malignant osteosarcoma and/or metastasis and the angiogenic activity of the tumour.
Department of Orthopaedics, Medical University of Vienna, Vienna, Austria.
G
G
Holzer
G
G
Hamilton
P
P
Angelberger
D
D
Lai
P
P
Ubl
R
R
Dudczak
M
M
Dominkus
S
S
Li
D001859:Bone Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009389:Neovascularization, Pathologic; D012516:Osteosarcoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D042461:Vascular Endothelial Growth Factor A; D051598:Whole Body Imaging / Q000379:methods*
D007457:Iodine Radioisotopes; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A