[Significance of the efflux phenomenon as a mechanism of bacterial resistance on active substances of biocide].
Efflux phenomenon induced by the presence of efflux pumps is one of the bacterial resistance mechanisms against active substances ofbiocides. Proteins and protein systems create efflux pumps, which are connected with the cell envelope structure ofbacteria. The efflux pump's function is transportation of active substances of disinfectants outside the bacterial cell. The biocides active substances rinsed out of bacterial cell by efflux were described for quaternary ammonium compounds, biguanides, phenols and diamidine. Bacterial resistance induced by efflux was not confirmed in the presence of such active substances like: alcohols, aldehydes, peroxides and chlorine compounds and their derivates. Bacterial resistance to active substance ofbiocides can be caused by two or more resistance mechanisms i.e. efflux mechanisms and reduce diffusion. The cooperation of resistance mechanisms to biocides can result difficulties in pathogenic bacteria eradication. The spread of these bacteria can be an epidemic threat.
Zakład Zwalczania Skazeń Biologicznych Narodowego Instytutu Zdrowia Publicznego--Państwowego Zakładu Higieny w Warszawie. achojecka@pzh.gov.pl
Agnieszka
A
Chojecka
Katarzyna
K
Jakubiec
Bozenna
B
Jakimiak
Ewa
E
Röhm-Rodowald
Krzysztof
K
Kanclerski
D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001426:Bacterial Proteins / Q000378:metabolism*; D018441:Biofilms / Q000187:drug effects; D002473:Cell Wall / Q000502:physiology; D004202:Disinfectants / Q000008:administration & dosage / Q000494:pharmacology*; D004203:Disinfection; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D026901:Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism*
D001426:Bacterial Proteins; D004202:Disinfectants; D026901:Membrane Transport Proteins