RNA polymerase backtracking in gene regulation and genome instability.
RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking--the reversible sliding of RNA polymerase along DNA and RNA--has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability.
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. evgeny.nudler@nyumc.org
Evgeny
E
Nudler
D001419:Bacteria / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D056890:Eukaryota / Q000235:genetics; D005786:Gene Expression Regulation; D042822:Genomic Instability; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
D012321:DNA-Directed RNA Polymerases