[Closed-chest porcine model is superior in intervention studies of ischaemia reperfusion injury].
Ischaemia reperfusion injury affects the patients' clinical outcomes. An animal model is therefore required in order to test pharmacological interventions and improve the current treatment of acute myocardial infarction (AMI). This review focuses on the endovascular closed-chest porcine model of ischaemia and reperfusion. In contrast to the open-chest porcine model the closed-chest model closely mimics the clinical situation of an AMI and makes it possible to extrapolate the results directly to humans. The model is well suited for future interventional studies.
Gastroenheden, Kirurgisk Sektion D, Herlev Hospital, Denmark. sarah_ekeloef@hotmail.com
Sarah Victoria Ekeløf
SV
Busch
Natalie Løvland
NL
Halladin
Svend Eggert
SE
Jensen
Jacob
J
Rosenberg
Ismail
I
Gögenur
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D000818:Animals; D021721:Balloon Occlusion / Q000009:adverse effects; D006328:Cardiac Catheterization / Q000379:methods*; D004195:Disease Models, Animal; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*; D013552:Swine; D013997:Time Factors