[Early administrations of statins after acute coronary syndrome].
In this Cochrane review the potential benefits and harms of early administrations of statins after acute coronary syndrome (ACS) were evaluated in 18 randomized trials including 14,303 patients. No statistically significant effect was found on the primary combined outcome of death, myocardial infarction and stroke, but at four-month follow-up the incidence of unstable angina pectoris was significantly reduced. Despite the lack of evidence for an additional effect of early statin administrations on hard clinical end points, we find good reasons to maintain statins in the early treatment of ACS.
Kardiologisk Sektion, Medicinsk Enhed, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark. jesper_linde@hotmail.com
Jesper James
JJ
Linde
Gorm Boje
GB
Jensen
D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000789:Angina, Unstable / Q000517:prevention & control; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D012196:Review Literature as Topic; D020521:Stroke / Q000517:prevention & control
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors