Residential environmental tobacco smoke exposure during pregnancy and low birth weight of neonates: case control study in a public hospital in Lucknow, India.
OBJECTIVE
To determine whether residential environmental tobacco smoke (ETS) exposure during pregnancy is associated with low birth weight (LBW) neonates and establish a dose response relationship.


METHODS
Case control study.


METHODS
Tertiary care hospital.


METHODS
Mothers giving birth to LBW neonate (<2.5 kg) were cases and those whose neonates weighed =2.5 kg at birth were controls. Excluded were women smokers and tobacco chewers, high parity (>3), multiple pregnancy and still births. Included were 100 cases and 200 controls, aged 20 to 30 years.  Information was collected on ETS exposure and other risk factors of LBW within 24 hours of delivery. Clinical information like maternal haemoglobin levels, birth weight and gestational age of the neonate was extracted from hospital records.


RESULTS
On univariate analysis, preterm pregnancy, low socioeconomic status, previous LBW neonate, no utilization of antenatal care (ANC), severe anemia and ETS exposure were statistically significantly associated with LBW neonate and controlling for these in logistic regression analysis, adjusted Odds ratio for ETS exposure association with LBW neonate was 3.16 (95% CI=1.88-5.28). A dose response relationship was also found which was statistically significant (10-20 cigarettes smoked/day: OR = 4.06, 95% CI=1.78-9.26 and >20 cigarettes smoked/day, OR = 17.62, 95% CI= 3.76-82.43).


CONCLUSIONS
Exposure to ETS during pregnancy is associated with LBW of neonates.  Hence, there is an urgent need to increase awareness about health hazards of ETS during pregnancy and bring about behavioural changes accordingly as a one of the strategies to reduce LBW deliveries in India.
Department of Pediatrics, King Georges Medical University, Lucknow, Uttar Pradesh, India.
Divya
D
Khattar
Shally
S
Awasthi
Vinita
V
Das
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006779:Hospitals, Public; D006801:Humans; D007194:India / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D011247:Pregnancy; D012907:Smoking / Q000453:epidemiology; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data*
D014028:Tobacco Smoke Pollution