High pressure study of molecular dynamics of protic ionic liquid lidocaine hydrochloride.
In this paper, we investigate the effect of pressure on the molecular dynamics of protic ionic liquid lidocaine hydrochloride, a commonly used pharmaceutical, by means of dielectric spectroscopy and pressure-temperature-volume methods. We observed that near T(g) the pressure dependence of conductivity relaxation times reveals a peculiar behavior, which can be treated as a manifestation of decoupling between ion migration and structural relaxation times. Moreover, we discuss the validity of thermodynamic scaling in lidocaine HCl. We also employed the temperature-volume Avramov model to determine the value of pressure coefficient of glass transition temperature, dT(g)/dP|(P = 0.1). Finally, we investigate the role of thermal and density fluctuations in controlling of molecular dynamics of the examined compound.
Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice, Poland.
A
A
Swiety-Pospiech
Z
Z
Wojnarowska
J
J
Pionteck
S
S
Pawlus
A
A
Grzybowski
S
S
Hensel-Bielowka
K
K
Grzybowska
A
A
Szulc
M
M
Paluch
D052578:Ionic Liquids / Q000737:chemistry*; D008012:Lidocaine / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D011312:Pressure; D013696:Temperature
D052578:Ionic Liquids; D008012:Lidocaine