Complex regional pain syndrome following spine surgery: clinical and prognostic implications.
BACKGROUND
Complex regional pain syndrome (CRPS) has been reported following spinal surgery, but its frequency after spinal surgery is unknown. The aim of this study was to determine the frequency of spinal surgery preceding CRPS and to examine these patients regarding the course of the disease and prognostic factors.


METHODS
We examined 35 CRPS patients regarding the symptoms and signs of CRPS, the type of CRPS (I or II), the origin and grade of the disease, the type of surgeries prior to CRPS onset, the course of the disease, and the therapies following diagnosis of CRPS.


RESULTS
In 6 patients, CRPS began during the postoperative course (lumbar spine surgery, n = 5; cervical spine surgery, n = 1). Four of these patients suffered from CRPS II. The course of the disease in the 6 patients was not different from that of patients with CRPS of other origins. First symptoms of CRPS could be observed 1-14 days after surgery.


CONCLUSIONS
CRPS is a rare complication after spinal surgery, but spinal surgery precedes the onset of CRPS of the lower limb in almost one-third of the cases. The first typical symptoms of CRPS emerge within 2 weeks after spinal surgery.
Interdisciplinary Pain Center, University Hospital Freiburg, Freiburg, Germany. tilman.wolter@uniklinik-freiburg.de
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Knöller
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Rommel
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D020918:Complex Regional Pain Syndromes / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D011379:Prognosis; D012189:Retrospective Studies; D013131:Spine / Q000601:surgery*; D055815:Young Adult