Preliminary studies of gastroprotective effect of Celtis iguanaea (Jacq.) Sargent leaves (Ulmaceae).
Antiulcerogenic activity of crude ethanolic extract of Celtis iguanaea leaves (CEE) was observed with experimental models such as ethanol, indomethacin, stress and pyloric ligation-induced gastric ulcers. Results obtained from indomethacin-induced ulcer showed the hexane fraction (HF) as the active fraction of CEE. This fraction inhibits the gastric acid secretion, increasing the gastric pH, decreasing the gastric acidity and total gastric contents. Neither the CEE nor the HF alters intestinal motility, thereby excluding a cholinergic antagonist mechanism. Further studies need to be conducted with HF in order to elucidate the active principle and the pharmacological mechanism involved.
Laboratório de Farmacologia de Produtos Naturais, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Brasil. fbs_cowboy@hotmail.com
Fábio Borges
FB
de Sousa
José Luís Rodrigues
JL
Martins
Iziara Ferreira
IF
Florentino
Renê Oliveira
RO
do Couto
Marcus Vinícius Mariano
MV
Nascimento
Pablinny Moreira
PM
Galdino
Paulo César
PC
Ghedini
José Realino
JR
de Paula
Elson Alves
EA
Costa
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006586:Hexanes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology; D014456:Ulcer / Q000139:chemically induced / Q000517:prevention & control; D034401:Ulmaceae / Q000737:chemistry*
D000897:Anti-Ulcer Agents; D006586:Hexanes; D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol; D007213:Indomethacin