Prognostic significance of adipocytokines in systolic heart failure patients.
OBJECTIVE
The goal of this study was designed to assess prognostic values of simultaneous measurement of adipocytokines in systolic heart failure (HF) patients.


METHODS
Patients with HF manifestations and left ventricular ejection fraction (LVEF) ≤ 50% were selected in this study. Gender, age, medications and serum biochemical data were recorded upon admissions. Adipocytokines including adiponectin, leptin, resistin, visfatin and retinol binding protein-4 were measured.


RESULTS
A total of 108 (83 males and 25 females) patients were enroled. The age was 62±15 years and mean LVEF was 35%. Twenty patients died during 776±323 days follow-up. In univariate analysis, mortality was found to be associated with the log-transformed values of serum resistin (β=5·616, P=0·04), log-transformed values of serum adiponectin (β=4·377, P=0·038), age (β=1·071, P<0·001), NTHA functional status (β=3·752, P=0·001) and body mass index (β=0·858, P=0·012). Patients with higher level of serum resistin were associated with higher mortality (P=0·012). In multivariate analysis, mortality is associated with log-transformed values of serum resistin (β=3·666, P=0·045), age (β=1·044, P=0·017) and NTHA functional status (β=2·541, P=0·025).


CONCLUSIONS
Serum resistin level was associated with higher mortality in systolic HF patients even after adjusting clinical parameters. Resistin may be an informative risk marker for systolic HF patients.
Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan.
Xue-Ming
XM
Wu
Yen-Hung
YH
Lin
Aaron
A
Chen
Tse-Pin
TP
Hsu
Yen-Wen
YW
Wu
Hung-Ju
HJ
Lin
Ron-Bin
RB
Hsu
Chi-Ming
CM
Lee
Shoei-Shen
SS
Wang
Men-Tzung
MT
Lo
Yi-Lwun
YL
Ho
Ming-Fong
MF
Chen
D054392:Adipokines / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood / Q000209:etiology / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000150:complications / Q000401:mortality
D054392:Adipokines; D015415:Biomarkers