Ovarian volume and gluco-insulinaemic markers in the diagnosis of PCOS during adolescence.
OBJECTIVE
To evaluate the role of mean ovarian volume (MOV) in the diagnosis of polycystic ovary syndrome (PCOS) during adolescence, and its relationship with metabolic and endocrine parameters.


METHODS
Observational study.


METHODS
A total of 134 young girls, including 86 adolescents with PCOS and 48 controls, were studied.


METHODS
During the early follicular phase, a pelvic ultrasound examination was performed to measure the ovarian volume of both ovaries and to calculate the MOV. All subjects underwent hormonal assessment and an ultrasound examination. PCOS subjects were submitted to an oral glucose tolerance test. The homeostasis model assessment for insulin resistance (HOMA-IR) and several insulin resistance indexes were also determined.


RESULTS
Androgens, free androgen index (FAI), LH and insulin resistance indexes were higher in the PCOS group. MOV was significantly different between the two groups: control group 4·6 ± 1·9 cm(3) , adolescent PCOS group 9·6 ± 4·4 cm(3) . The MOV threshold of 5·596 cm(3)  offered the best compromise between sensitivity and specificity based on the characteristics of the operating receiver curve analysis. Therefore, an ovarian volume higher than 5·6 increased the risk of PCOS by about 15 times (OR 16·25 IC 95% 6·3-41·3). In adolescent PCOS girls, the ovarian volume was significantly associated with circulating testosterone and insulin, and indices of insulin resistance.


CONCLUSIONS
During early adolescence MOV evaluation may offer an effective means to screen and follow up young girls with irregular cycles in order to prevent the long-term metabolic disturbances of the polycystic ovary syndrome.
Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Largo F. Vito 1, Rome, Italy. paolavilla@rm.unicatt.it
Paola
P
Villa
Aurora
A
Rossodivita
Francesca
F
Sagnella
Maria Cristina
MC
Moruzzi
Nicoletta
N
Mariano
Anna Pia
AP
Lassandro
Alfredo
A
Pontecorvi
Giovanni
G
Scambia
Antonio
A
Lanzone
D000293:Adolescent; D001786:Blood Glucose; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D016017:Odds Ratio; D010053:Ovary / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000473:pathology*
D001786:Blood Glucose