Maternal homocystinuria and Moebius syndrome? Vascular aetiology.
A case of Moebius syndrome is reported in an infant of a mother known to have pyridoxine-unresponsive homocystinuria. The authors suggest that Moebius syndrome could result from early vascular insufficiency or disruption occurring early in development related to maternal homocystinuria. Moebius syndrome consists of congenital complete or partial facial nerve palsy with or without paralysis of other cranial nerves and often in association with other malformations of the limbs and orofacial structures, but usually without gross structural brain abnormalities.
Neonatal Unit, John Radcliffe Hospital, Oxford, UK. neelam27@doctors.org.uk
N
N
Gupta
M Y
MY
Anthony
D005260:Female; D006712:Homocystinuria; D006801:Humans; D007231:Infant, Newborn; D020331:Mobius Syndrome / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications; D014652:Vascular Diseases / Q000150:complications*