[Carcinosarcomas of the uterus: molecular-genetic and morphological features].
13 cases of uterine carcinosarcomas have been studied by molecular-genetic method. The impairment of some genes (K-RAS gene in the first exon, TP53 in the 5th-9th exons, PTEN in the 5th and 8th exons) has been found out. The loss of heterozygosity of TP53 gene in epithelium and mesenchyme of the uterus has been detected. According to the estimation of impairment the studied tumors was divided into monoclonal and biclonal ones. This stratification could be use as prognostic criteria of uterine carcinosarcomas clinical presentation.
N V
NV
Levitskaia
K M
KM
Pozharisskiĭ
O A
OA
Vostriukhina
L N
LN
Alekseeva
M V
MV
Nemtsova
I V
IV
Matrosova
T V
TV
Kharitonova
I V
IV
Poddubnaia
D002296:Carcinosarcoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005091:Exons; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D014594:Uterine Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D016283:Proto-Oncogene Proteins p21(ras)