Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis.
To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.
Tianjin Lung Cancer Institute, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, China.
Yibing
Y
Yao
Yu
Y
Fan
Jun
J
Wu
Haisu
H
Wan
Jing
J
Wang
Stephen
S
Lam
Wan L
WL
Lam
Luc
L
Girard
Adi F
AF
Gazdar
Zhihao
Z
Wu
Qinghua
Q
Zhou
D000912:Antibodies, Neoplasm / Q000097:blood*; D000951:Antigens, Neoplasm / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000276:immunology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D055088:Early Detection of Cancer; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis / Q000276:immunology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000276:immunology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000096:biosynthesis / Q000276:immunology; D019151:Peptide Library; D010750:Phosphoproteins / Q000096:biosynthesis / Q000276:immunology; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000096:biosynthesis / Q000276:immunology; D000097667:Polyamine Oxidase
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; D018960:Hyaluronan Receptors; D009687:Nuclear Proteins; D000587:Oxidoreductases Acting on CH-NH Group Donors; D019151:Peptide Library; D010750:Phosphoproteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D000097667:Polyamine Oxidase; C557041:MALAT1 long non-coding RNA, human; C075564:NOLC1 protein, human; C098946:hyaluronan-mediated motility receptor