Developments in the prevention of transfusion-associated graft-versus-host disease.
The transfusion of blood products can result in a variety of consequences, including transfer of pathogens and the induction of immune responses, such as the almost invariably fatal transfusion-associated graft-versus-host disease (TA-GVHD). Exposure of blood products to γ-irradiation is currently the standard of care for the prevention of TA-GVHD. Regulatory, technical and clinical challenges associated with the use of γ-irradiators are driving efforts to develop alternatives. Initially, pathogen reduction methods were developed to reduce the risk of microbial transmission by blood components. Through modifications of nucleic acids, these technologies interfere with the replication of both pathogens and leucocytes. These methods have been found to be as effective as γ-irradiation in preventing T lymphocyte proliferation and TA-GVHD responses. Additional benefits of pathogen reduction protocols potentially include inhibition of antigen presentation, cytokine production and activation of lymphocytes.
Division of Hematology/Oncology, Rhode Island Hospital and Alpert School of Medicine at Brown University, Providence, RI 02903, USA. loren_fast@brown.edu
Loren D
LD
Fast
D001773:Blood Cells / Q000276:immunology; D016913:Blood Component Transfusion / Q000009:adverse effects; D005720:Gamma Rays / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D047589:Leukocyte Reduction Procedures / Q000379:methods; D011073:Polyamines / Q000627:therapeutic use; D018805:Sepsis / Q000517:prevention & control; D065227:Transfusion Reaction; D014467:Ultraviolet Therapy
C451719:PEN 110; D011073:Polyamines