IL-33/ST2 axis in innate and acquired immunity to tumors.
Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
Center for Molecular Medicine and Stem Cell Research; Faculty of Medicine; University of Kragujevac; Kragulevac, Serbia.
Ivan P
IP
Jovanovic
Nada N
NN
Pejnovic
Gordana D
GD
Radosavljevic
Nebojsa N
NN
Arsenijevic
Miodrag L
ML
Lukic