Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.
Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Marta
M
Owczarek-Lipska
Béatrice
B
Lauber
Vivianne
V
Molitor
Sabrina
S
Meury
Marcin
M
Kierczak
Katarina
K
Tengvall
Matthew T
MT
Webster
Vidhya
V
Jagannathan
Yvette
Y
Schlotter
Ton
T
Willemse
Anke
A
Hendricks
Kerstin
K
Bergvall
Ake
A
Hedhammar
Göran
G
Andersson
Kerstin
K
Lindblad-Toh
Claude
C
Favrot
Petra
P
Roosje
Eliane
E
Marti
Tosso
T
Leeb
D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000235:genetics*; D004285:Dogs; D007073:Immunoglobulin E / Q000097:blood*
D007073:Immunoglobulin E