Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature.
Otitis media is one of the common organ injuries that appear during the course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We experienced four patients with myeloperoxidase (MPO)-ANCA-positive AAV with otitis media. All were elderly Japanese women. MPO-ANCA in our patients was reminiscent of microscopic polyangiitis (MPA), although chest computed tomography (CT) scans revealed characteristics of both granulomatosis with polyangiitis (GPA), showing bronchial lesions and nodule formation, and MPA, showing interstitial changes. Whether our cases should be classified as GPA or MPA is a matter of discussion. We detail their profiles, and review previous literature on MPO-ANCA-positive AAV with otitis media.
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, 5-30 Kitatakamatsu-cho, Miyazaki, Miyazaki 880-8510, Japan. nono@pref-hp.miyazaki.miyazaki.jp
Nobuyuki
N
Ono
Kyoko
K
Yoshihiro
Daisuke
D
Oryoji
Motohiro
M
Matsuda
Yoshihiro
Y
Ueki
Shigehiro
S
Uezono
Yasufumi
Y
Kai
Daisuke
D
Himeji
Hiroaki
H
Niiro
Akira
A
Ueda
D000369:Aged, 80 and over; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D010033:Otitis Media / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D012263:Ribonucleosides / Q000627:therapeutic use; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D009195:Peroxidase