[Drastic changes in serotypes of carried pneumococci due to an increased vaccination rate in Hungary].
Introduction of the conjugate pneumococcal vaccine into the voluntary childhood vaccine program in Hungary in April 2009 resulted in a sharp increase of the vaccination rate. However, changes in serotypes as a consequence of vaccination should be considered.


OBJECTIVE
The aim of the authors was to compare pneumococci isolated from children with high-level and low-level vaccination rates.


METHODS
Nasal specimens from 854 children attending 20 nurseries at various locations in Hungary have been collected since 2009. The serotypes, antibiotic susceptibility and genetic relatedness of the isolated pneumococci were determined.


RESULTS
324 strains were isolated, and the carriage rate was 37.94%. The strains were sensitive to most antibiotics, except for macrolides. A definite suppression of vaccine types was detected during these 3 years, from the initial 78.85% to 35.30%.


CONCLUSIONS
The authors conclude that the results reflect the efficacy of the vaccine, which underlines the need for the inclusion of pneumococcal vaccine into the list of obligatory vaccines.
Semmelweis Egyetem, Általános Orvostudományi Kar Orvosi Mikrobiológiai Intézet Budapest Nagyvárad tér 4. 1089.
Adrienn
A
Tóthpál
Orsolya
O
Dobay
D002353:Carrier State; D006801:Humans; D006814:Hungary; D007223:Infant; D032541:Mass Vaccination / Q000706:statistics & numerical data / Q000639:trends*; D009666:Nose / Q000382:microbiology; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000302:isolation & purification; D018074:Vaccines, Conjugate / Q000008:administration & dosage
D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate