Urinary sodium to creatinine ratio in healthy infants.
Rationale Sodium is essential for adequate growth; the daily requirement in infants is 2 to 3 mmol/kg/d.  Objectives The study aimed to establish a reference range for the ratio of urinary sodium (UNa) to creatinine (UCr) in healthy infants in a suburban setting in the United States.  Methods UNa and UCr were measured in healthy infants and UNa:UCr was calculated. Daily sodium intake was estimated by parental report.  Results Mean estimated sodium intake in the 71 infants was 1.34 mEq/kg/d (95% confidence interval = 1.23-1.44). The mean UNa:UCr was 11.73 (95% confidence interval = 10.24-13.23) and did not differ significantly in age-groups. There was no direct correlation between sodium intake and UNa:UCr in healthy infants.  Conclusions The UNa:UCr was 11.73 in this population of healthy infants. This likely reflects the appropriate physiologic response to sodium intake in the study population, which was at the lower end of the usual estimated needs for infants.
Baylor College of Medicine, Houston, TX 77030, USA. mcmann@texaschildrenshospital.org
Michelle
M
Mann
Wayne
W
Waz
James
J
Poupoulos
Rohini
R
Kadle
Ariella
A
Korn
Russell
R
Vaughan
Drucy
D
Borowitz
D017677:Age Distribution; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine*; D003430:Cross-Sectional Studies; D004032:Diet; D004034:Diet Surveys; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016014:Linear Models; D009518:New York; D012016:Reference Values; D012964:Sodium / Q000652:urine*; D012982:Sodium, Dietary; D018881:Suburban Health
D015415:Biomarkers; D012982:Sodium, Dietary; D012964:Sodium; D003404:Creatinine