[Macular hole and Alport's syndrome].
METHODS
We present the clinical cases of two male patients of 38 and 39 years, diagnosed with Alport's syndrome, who suffered a bilateral macular hole and a giant unilateral macular hole with retinal thinning in the other eye, respectively.


CONCLUSIONS
Alport's syndrome is a genetic disorder characterised by mutation of genes encoding type IV collagen, the main component of the internal limiting membrane, a structure identified in basal membrane of the retinal pigment epithelium-Brüch's membrane complex. This alteration can influence the predisposition to macular holes.
Servicio de Oftalmología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. gilorio_79@hotmail.com
R
R
Rodríguez-Gil
M A
MA
Gil-Hernández
A
A
Afonso-Rodríguez
D000328:Adult; D006801:Humans; D008297:Male; D009394:Nephritis, Hereditary / Q000150:complications*; D012167:Retinal Perforations / Q000209:etiology*