Lysine modifications and autophagy.
Nutrient deprivation or cellular stress leads to the activation of a catabolic pathway that is conserved across species, known as autophagy. This process is considered to be adaptive and plays an important role in a number of cellular processes, including metabolism, immunity and development. Autophagy has also been linked to diseases, such as cancer and neurodegeneration, highlighting the importance of a better insight into its regulation. In the present chapter, we discuss how PTMs (post-translational modifications) of lysine residues by acetylation and ubiquitination alter the function of key proteins involved in the activation, maturation and substrate selectivity of autophagy. We also discuss the clinical potential of targeting these modifications to modulate autophagic activities.
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, U.S.A.
Kristi L
KL
Norris
Tso-Pang
TP
Yao
D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000235:genetics / Q000502:physiology; D054875:Ubiquitination
D008239:Lysine