Improved antibacterial activity of cephalosporins loaded in magnetic chitosan microspheres.
During the present study, we have evaluated magnetic chitosan as a potential drug delivery device, by specifically determining if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting Staphylococcus aureus and Escherichia coli growth. We have demonstrated that the incorporation of cephalosporins of second, third and fourth generation into magnetic chitosan microspheres can possibly lead to an improved delivery of antibiotics in active forms, probably due to the inherent properties of chitosan.
Faculty of Biology, University of Bucharest, Romania.
Carmen Mariana
CM
Chifiriuc
Alexandru Mihai
AM
Grumezescu
Crina
C
Saviuc
Cristina
C
Croitoru
Dan Eduard
DE
Mihaiescu
Veronica
V
Lazar
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D048271:Chitosan / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D007501:Iron / Q000737:chemistry; D060328:Magnetic Phenomena; D008826:Microbial Sensitivity Tests; D008863:Microspheres; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D048271:Chitosan; D007501:Iron