[New bioaffine sorbents for selective elimination of autoantibodies against human thyroperoxidase in autoimmune thyroid diseases].
New bioaffine sorbents containing bioselective ligand, synthetic analog of the human thyroperoxidase antigenic determinant--tetrapeptide H-Glu-Gln-betaAla-Lys-OMe, immobilized on two polymeric matrixes--a polyacrylamide gel and CNBr-activated sepharose 4B were synthesized. The offered immunosorbents were shown have high selectivity in relation to autoantibodies against thyroperoxidase and can find an application for medicine and experimental biochemistry for selective elimination of autoantibodies from serum or plasma of the patients suffering from autoimmune thyroid diseases.
O V
OV
Gribovsakaia
I V
IV
Shutova
O V
OV
Tsyganova
V P
VP
Martinovich
V P
VP
Golubovich
D000180:Acrylic Resins / Q000737:chemistry; D001323:Autoantibodies / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D001327:Autoimmune Diseases / Q000276:immunology*; D002846:Chromatography, Affinity / Q000379:methods; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000276:immunology; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D007164:Immunosorbents / Q000097:blood / Q000138:chemical synthesis / Q000737:chemistry*; D007453:Iodide Peroxidase / Q000276:immunology*; D009842:Oligopeptides / Q000097:blood / Q000138:chemical synthesis / Q000737:chemistry*; D012685:Sepharose / Q000737:chemistry; D013959:Thyroid Diseases / Q000276:immunology*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D001323:Autoantibodies; D004800:Enzymes, Immobilized; D000939:Epitopes; D007164:Immunosorbents; D007453:Iodide Peroxidase; D009842:Oligopeptides; D012685:Sepharose; D000099166:Polyacrylamides