EGFR inhibitors, MHC expression and immune responses : Can EGFR inhibitors be used as immune response modifiers?
A recent study from our laboratory demonstrated that epidermal growth factor receptor (EGFR) inhibitors (EGFRIs) augment the expression of class I and class II MHC molecules. This finding provides an additional mechanism through which EGFRIs may exert anti-tumor effects and supports the notion that EGFRIs may influence adaptive immune responses by altering immune gene expression.
Emory University School of Medicine, Decatur, GA.
Brian P
BP
Pollack