A 45-bp insertion/deletion polymorphism in uncoupling protein 2 is not associated with obesity in a Chinese population.
The association of a 45-bp insertion/deletion (UCP2-45 bp I/D) polymorphism in uncoupling protein 2 with body mass index (BMI) remains controversial. A case-control study was conducted to examine the association in a Chinese population. The 1,526 subjects recruited in downtown Beijing and genotyped included 616 obese subjects with BMI >28 and 910 age- and gender-matched controls with BMI <24. The association of the polymorphisms with obesity was estimated using multivariate logistic regression in three models of inheritance. The odds ratios were 1.08 (95 % CI 0.846-1.368; P = 0.551) in the dominant model, 0.931 (0.751-1.154; P = 0.513) in the additive model, and 1.18 (0.550-2.550; P = 0.666) in the recessive model. The overall comparison of the genotype distributions in obese and control subjects using the chi-square test yielded P = 0.801. Our study demonstrated no association between UCP2-45 bp I/D and BMI variation in the Chinese population.
Department of Epidemiology, Public Health School, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin, Heilongjiang, China.
Xiaoqiu
X
Liu
Bin
B
Zhang
Xin
X
Liu
Yue
Y
Shen
Jiana
J
Li
Nan
N
Zhao
Lina
L
Ma
Qingmao
Q
Du
Lisheng
L
Liu
Jingbo
J
Zhao
Xingyu
X
Wang
D000328:Adult; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population / Q000379:methods; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D007473:Ion Channels / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D000071246:Uncoupling Protein 2
D007473:Ion Channels; D008077:Lipoproteins, LDL; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2