Chromatin organizer SATB1 is an important determinant of T-cell differentiation.
T-cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation. SATB1 mediates Wnt signaling by recruiting β-catenin to its genomic targets and coordinates T helper type 2 (T(H)2) differentiation by positively regulating GATA-3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1-mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells.
Centre of Excellence in Epigenetics, Indian Institute of Science Education and Research, Pune, India.
Mithila
M
Burute
Kamal
K
Gottimukkala
Sanjeev
S
Galande
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology*; D002843:Chromatin / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
D002843:Chromatin; D050990:GATA3 Transcription Factor; D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human