Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women.
OBJECTIVE
Alveolar cancellous bone biopsy samples were extracted during dental implant preparation for investigating microstructural changes due to menopause and relationships between these changes and bone turnover markers.


METHODS
Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (≤5 years; n = 3), and late postmenopausal (>5 years; n = 10). Bone turnover markers were measured and the samples analyzed using microscopic computerized tomography and 3-dimensional bone morphometry.


RESULTS
The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones (P < .05). Each alveolar bone parameter was significantly (P < .05) related to at least 1 bone turnover marker.


CONCLUSIONS
Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers.
Division of Comprehensive Prosthodontics, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Emi
E
Yamashita-Mikami
Mikako
M
Tanaka
Naoki
N
Sakurai
Yoshiaki
Y
Arai
Akira
A
Matsuo
Hayato
H
Ohshima
Shuichi
S
Nomura
Sadakazu
S
Ejiri
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000539:Alveolar Process / Q000378:metabolism / Q000648:ultrastructure*; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001706:Biopsy; D015519:Bone Density / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D017698:Postmenopause / Q000502:physiology*; D017697:Premenopause / Q000502:physiology*; D055114:X-Ray Microtomography / Q000379:methods; D055815:Young Adult
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase