Non-replication of an association of Apolipoprotein E2 with sinistrality.
A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ϵ2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ϵ2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA. psy391@gmail.com
Brian J
BJ
Piper
Alia L
AL
Yasen
Amy E
AE
Taylor
Jonatan R
JR
Ruiz
J William
JW
Gaynor
Catherine A
CA
Dayger
Marcela
M
Gonzalez-Gross
Oh D
OD
Kwon
Lars-Göran
LG
Nilsson
Ian N M
IN
Day
Jacob
J
Raber
Jeremy K
JK
Miller
D000293:Adolescent; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D007839:Functional Laterality / Q000235:genetics*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D055815:Young Adult
D001057:Apolipoproteins E