Pharmacological evaluation of fruits of Terminalia belerica Roxb. for antiulcer activity.
The antiulcer activity of 70% methanolic extract of fruits of Terminalia belerica Roxb. (Combretaceae) was evaluated using ethanol induced, aspirin induced, cold stress restraint and pylorus ligated ulcer in rats. The methanolic extract (100, 250, 500, 1000 mg/kg, p.o.) significantly suppressed the peptic ulcer induced by ethanol. Methanolic extract at a dose of 500 mg/kg showed, promising antiulcer activity hence, this dose was selected for further evaluation of antiulcer studies. The methanolic extract (500 mg/kg) showed significant (p<0.05) reduction in gastric volume, free acidity, total acidity, ulcer index, protein and pepsin content and increase in mucus content in pylorus ligated rats as compared to control. Treatment with Terminalia belerica methanolic extract further provided significant antiulcer protection against aspirin induced ulcers but not in cold stress restraint model. These results suggested that the 70% methanolic extract of Terminalia belerica increased resistance to necrotizing agents, providing a direct protective effect on the gastric mucosa and exhibited antiulcer effect.
IPS Academy, Indore, India.
Hitesh
H
Jawanjal
Mithun S
MS
Rajput
Purti
P
Agrawal
Vikramsingh
V
Dange
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin; D015415:Biomarkers / Q000378:metabolism; D003080:Cold Temperature; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D000431:Ethanol; D005260:Female; D005638:Fruit; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008026:Ligation; D008297:Male; D008515:Medicine, Ayurvedic; D000432:Methanol; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D029766:Terminalia
D000897:Anti-Ulcer Agents; D015415:Biomarkers; D010936:Plant Extracts; D000431:Ethanol; D001241:Aspirin; D000432:Methanol