Recent trends in development of biosensors for detection of microcystin.
Increased cyanobacterial blooms, a source of cyanotoxins are linked with climate change and eutrophication in aquatic bodies, a major concern worldwide. Microcystins are potently hepatotoxic, nephrotoxic as well as carcinogenic. Thus microcystins are threat to tourism, agriculture and animal's health. However, there is a still lacuna in the knowledge of regulation of microcystins production. Presence of toxic and non-toxic cyanobacterial strains together and occurrence of various microcystin variants in aquatic bodies compounded the problem. Although several analytical techniques for microcystin detection such as bioassay, ELISA, HPLC and LC-MS etc. have been already prevalent, the development of biosensors offered rapid and accurate detection, high reproducibility and portability. Sequencing of Microcystis spp., opened the new vistas towards the development of biosensor at molecular and genetic level. This review incorporates the current trends in the development of biosensors for microcystin detection in the light of state-of-the-art techniques.
Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221005, India.
Shweta
S
Singh
Ankita
A
Srivastava
Hee-Mock
HM
Oh
Chi-Yong
CY
Ahn
Gang-Guk
GG
Choi
Ravi Kumar
RK
Asthana
D015374:Biosensing Techniques / Q000379:methods*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D000458:Cyanobacteria / Q000737:chemistry*; D052998:Microcystins / Q000032:analysis* / Q000235:genetics*; D015394:Molecular Structure; D014876:Water Pollution / Q000032:analysis*
D052998:Microcystins