Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells.
Attempts are being made to identify genes targeted by morphine. It is beneficial for developing new treatments that alleviate side-effects of morphine. Thioredoxin-1 is a small ubiquitous protein that has various biological activities, such as the control of redox balance, the inhibition of apoptosis and the modulation of inflammation. In this study, we found that thioredoxin-1 was induced by morphine in SH-SY5Y cells. Furthermore, opioid receptor, PI3K and ERK pathways were involved in morphine-induced increase of thioredoxin-1 expression. These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. More detailed analysis could clarify cellular and molecular mechanisms involved in the actions of morphine.
Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China.
Fu-Cheng
FC
Luo
Yue-Mei
YM
Feng
Lu
L
Zhao
Kui
K
Li
Sheng-Dong
SD
Wang
Jun-Ying
JY
Song
Jie
J
Bai
D000701:Analgesics, Opioid / Q000008:administration & dosage; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000008:administration & dosage*; D009447:Neuroblastoma / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism*
D000701:Analgesics, Opioid; D011957:Receptors, Opioid; D013879:Thioredoxins; D009020:Morphine; D019869:Phosphatidylinositol 3-Kinases