Structure and function of the ubiquitin-proteasome system: modulation of components.
The ubiquitin-proteasome system (UPS) is directly or indirectly involved in all aspects of the cellular metabolic networks linked to either normal or pathologic processes. The highly orchestrated coordination of the many different parts that constitute the UPS augments the levels of difficulty in elucidating the unknown regulatory mechanisms of the system. At the same time, this increased complexity endows the system with the possibility of interfering in its different parts, depending on the surrounding cellular conditions and still specifically modulating the whole pathway. In this chapter, the main features of the UPS are summarized, with special attention given to the current data regarding the modulation of the different parts of this major system, either via genetic intervention or via treatment with naturally occurring or synthetic compounds.
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
Niki
N
Chondrogianni
Efstathios S
ES
Gonos
D000818:Animals; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology / Q000628:therapy; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D025801:Ubiquitin / Q000737:chemistry* / Q000378:metabolism*
D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex