[Expression and significances of FSCN1 and HGF in nasal inverted papilloma].
OBJECTIVE
To study the expressions of FSCN1 and HGF in nasal inverted papilloma (NIP) and explore their role in occurrence and development of this disease.


METHODS
Immunohistochemical method was used to determine the expression of FSCN1 and HGF in 12 cases of chronic hypertrophic rhinitis, 40 cases of NIP and 14 cases of NIP with malignant transformation.


RESULTS
FSCN1 was expressed in 52.5% of NIP, 78.6% of NIP with malignant transformation and 8.3% of inferior turbinate of chronic hypertrophic rhinitis. Expression of FSCN1 was significantly higher in NIP and NIP with malignant transformation than in inferior turbinate (P<0.05). HGF was expressed in 85.7% of NIP with malignant transformation and 8.3% of inferior turbinate. Expression of HGF was significantly higher in NIP with malignant transformation than in inferior turbinate (P<0.05). HGF was expressed in 40.0% of NIP,which was higher than that of inferior turbinate. Expression of HGF was positively related to expression of FSCN1 in NIP and NIP with malignant transformation.


CONCLUSIONS
The abnormal expression of FSCN1 and HGF may be closely correlated with NIP and its malignant process. Analysis of FSCN1 and HGF expression in NIP may be useful in predicting malignant transformation.
Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Linlin
L
Yuan
Weihua
W
Lou
Jianzhong
J
Sang
D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D017228:Hepatocyte Growth Factor / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009669:Nose Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018308:Papilloma, Inverted / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014420:Turbinates / Q000378:metabolism* / Q000473:pathology
D002352:Carrier Proteins; C502658:FSCN1 protein, human; C066855:HGF protein, human; D008840:Microfilament Proteins; D017228:Hepatocyte Growth Factor