Single nucleotide polymorphisms in the regulatory region of gonadotropin-releasing             hormone receptor gene and breast cancer susceptibility.
It is known that exposure to estrogens affects the pathophysiology of breast             cancer. The key role of gonadotropin-releasing hormone (GnRH) in the regulation             of female steroid hormone metabolism raises the question of whether polymorphisms             in its receptor, GnRHR, might influence breast cancer risk. To test this hypothesis,             we analyzed three single nucleotide polymorphisms (SNPs) in the 5'-regulatory             region of the GnRHR gene in a total of 565 women, 254 women with breast cancer             and 311 women without any malignancy by allele-specific PCR. No significant differences             were observed between the breast cancer and control group in terms of genotype,             allele frequency or allele positivity. In contrast, different frequencies of the             SNPs rs13138607, rs12644822 and rs3756159 were observed after sub-grouping the             breast cancer cases according to tumor grading. Our data suggest a potential role             of GnRHR gene polymorphisms in the development of breast cancer.
Department of Obstetrics and Gynecology, University Medical Center                     Regensburg, D-93057 Regensburg, Germany.
Claus
C
Lattrich
Anna-Kristin
AK
Müller
Susanne
S
Schüler
Julia
J
Häring
Alexandra
A
Ruoff
Oliver
O
Treeck
Olaf
O
Ortmann
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D004742:Enhancer Elements, Genetic; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011966:Receptors, LHRH / Q000235:genetics*; D017422:Sequence Analysis, DNA; D055815:Young Adult
D011966:Receptors, LHRH