[Research progress on immunocyte senescence - review].
The function of immune system degenerates in an aging-dependent manner and this results in immunosenescence. Human immune system includes two parts: genetic/innate immunity and adaptive immunity. The former is involved in monocytes, nature killer cells, and dendritic cells, the later is involved in acquired B and T lymphocytes. During the aging of immunity system, the both parts of immunity are damaged to some degree. Generally, innate immunity seems well-retained and the acquired immunity is degenerative seriously with aging. Immunocyte senescence is closely related to the elderly decreased ability to control infectious disease, cancer and to their generally poor response to vaccination. This review summarized the research progress on immunosenescence characteristics in aged phase.
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China.
Bo
B
Yang
Xiao-Hua
XH
Chi
Xue-Chun
XC
Lu
Shuai
S
Tuo
Feng
F
Zhang
Wen-Ying
WY
Zhang
Chao-Wei
CW
Tuo
Wei-Dong
WD
Han
Shan-Qian
SQ
Yao
D000367:Age Factors; D000375:Aging / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D016922:Cellular Senescence; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008213:Lymphocyte Activation