Binuclear copper(II), cobalt(II) and nickel(II) complexes of N1-ethyl-N2-(pyridin-2-yl) hydrazine-1,2-bis(carbothioamide): structural, spectral, pH-metric and biological studies.
Binuclear Cu(II), Co(II) and Ni(II) complexes derived from N(1)-ethyl-N(2)-(pyridin-2-yl) hydrazine-1,2-bis(carbothioamide) (H(2)PET) have been prepared and characterized by elemental analysis, spectral (IR, UV-vis, EI mass, ESR and (1)HNMR) and magnetic measurements. The isolated complexes assigned the general formula, [M(HPET)(H(2)O)(n)Cl](2)·xH(2)O where M=Cu(II), Co(II) and Ni(II), n=2, 1, 0 and x=0, 0.5 and 0, respectively. IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(∗) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group. In Ni(II) complex, H(2)PET acts as NSNS monobasic tetradente via (CN)(py), (C-S), (CS) and the new azomethine, (NC)(∗) groups. An octahedral geometry is proposed for all complexes. pH- metric titration was carried out in 50% dioxane-water mixture at 298, 308 and 318 °K, respectively and the dissociation constant of the ligand as well as the stability constants of its complexes were evaluated. Also the kinetic and thermodynamic parameters for the different thermal decomposition steps of the complexes were determined by Coats-Redfern and Horowitz-Metzger methods. Moreover, the anti-oxidant, anti-hemolytic, and cytotoxic activities of the compounds have been tested.
Department of Chemistry, Faculty of Science, Mansoura University, P.O. Box 70, Mansoura, Egypt.
O A
OA
El-Gammal
G M
GM
Abu El-Reash
M M
MM
El-Gamil
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001201:Ascites / Q000473:pathology; D003035:Cobalt / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D004912:Erythrocytes / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006834:Hydrazines / Q000737:chemistry* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007700:Kinetics; D060328:Magnetic Phenomena; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009532:Nickel / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D013818:Thermogravimetry
D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D006834:Hydrazines; C029424:hydrazine; D003035:Cobalt; D003300:Copper; D009532:Nickel