Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion.
Smart surfaces presenting both antifouling molecules with a charged functional group at their distal end, and molecules that are terminated by RGD peptides for cell adhesion, were fabricated and characterized (see picture). By applying potentials of +300 or -300 mV, the surfaces could be dynamically switched to make the peptide accessible or inaccessible to cells.
School of Chemistry and Australian Centre for NanoMedicine, The University of New South Wales, Sydney NSW 2052, Australia.
Cheuk Chi Albert
CC
Ng
Astrid
A
Magenau
Siti Hawa
SH
Ngalim
Simone
S
Ciampi
Muthukumar
M
Chockalingham
Jason Brian
JB
Harper
Katharina
K
Gaus
John Justin
JJ
Gooding
D002448:Cell Adhesion / Q000187:drug effects; D004583:Electrons; D018922:HL-60 Cells; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry*; D013499:Surface Properties
D009842:Oligopeptides; D000644:Quaternary Ammonium Compounds; D013451:Sulfonic Acids; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid