Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis.
Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM; U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; Cnrs; UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Department of Medical Oncology; Centre Léon Bérard; Lyon, France.
Sana Intidhar
SI
Labidi-Galy
Isabelle
I
Treilleux
Sophie
S
Goddard-Leon
Jean-Damien
JD
Combes
Jean-Yves
JY
Blay
Isabelle
I
Ray-Coquard
Christophe
C
Caux
Nathalie
N
Bendriss-Vermare