Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche.
DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for impeding tumor-specific immune responses, linking chemoresistant niche with tumor immune evasion.
Research Center for Infection-Associated Cancer; Institute for Genetic Medicine; Hokkaido University; Sapporo, Japan.
Masahisa
M
Jinushi