CD73 promotes tumor growth and metastasis.
Our recent data and that of others demonstrate that both tumor and host CD73-generated adenosine promote tumor growth and metastasis in a multifactorial manner. Results with small molecule inhibitors or monoclonal antibodies against CD73 in multiple tumor models suggest that CD73 is a previously unappreciated important target for effective cancer therapy.
Department of Medicine; Cancer Therapy & Research Center; University of Texas Health Sciences Center; San Antonio, TX USA.
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Zhang