New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker.
Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well as by means of HR-MS. The structure of 1 was firmly confirmed by X-ray crystallography, and the absolute configuration was revealed by experimental and computational optical rotation analyses. Cytotoxicities of 1-4 were measured in vitro against 10 selected cancer cell lines.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Hai-Long
HL
Jiang
Xiao-Hong
XH
Luo
Xiao-Zheng
XZ
Wang
Jun-Li
JL
Yang
Xiao-Jun
XJ
Yao
Phillip
P
Crews
Frederick A
FA
Valeriote
Quan-Xiang
QX
Wu
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003058:Cockroaches / Q000737:chemistry*; D006801:Humans; D049934:Isocoumarins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*
D000470:Alkaloids; D000970:Antineoplastic Agents; D049934:Isocoumarins