Tumor microenvironment in NSCLC suppresses NK cells function.
NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.
Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de Recherche des Cordeliers; Paris, France ; Université Pierre et Marie Curie; Paris, France.
Isabelle
I
Cremer
Wolf Herman
WH
Fridman
Catherine
C
Sautès-Fridman