Role of chromatography in the development of Standard Reference Materials for organic analysis.
The certification of chemical constituents in natural-matrix Standard Reference Materials (SRMs) at the National Institute of Standards and Technology (NIST) can require the use of two or more independent analytical methods. The independence among the methods is generally achieved by taking advantage of differences in extraction, separation, and detection selectivity. This review describes the development of the independent analytical methods approach at NIST, and its implementation in the measurement of organic constituents such as contaminants in environmental materials, nutrients and marker compounds in food and dietary supplement matrices, and health diagnostic and nutritional assessment markers in human serum. The focus of this review is the important and critical role that separation science techniques play in achieving the necessary independence of the analytical steps in the measurement of trace-level organic constituents in natural matrix SRMs.
Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. stephen.wise@nist.gov
Stephen A
SA
Wise
Karen W
KW
Phinney
Lane C
LC
Sander
Michele M
MM
Schantz
D002845:Chromatography / Q000379:methods* / Q000592:standards*; D013058:Mass Spectrometry / Q000379:methods / Q000592:standards; D009930:Organic Chemicals / Q000032:analysis*; D012015:Reference Standards
D009930:Organic Chemicals