[Clinical study of different bowel preparations on changes of gut flora in patients undergoing colorectal resection].
OBJECTIVE
To compare the impact of traditional and fast bowel preparation on the changes of gut flora in the patients following colorectal resection.


METHODS
Sixty patients undergoing colorectal resection from March 2010 to March 2011 in the Nanfang Hospital were randomly divided into the control group(n=27, 3 days of bowel preparation) and the experimental group(n=33, 1 day of bowel preparation). Fresh feces were collected before bowel preparation and on the first defecation after surgery. The postoperative changes in gut flora and septic complications were observed.


RESULTS
Gut flora disturbance was found in both groups. The postoperative population of Bifidobacterium and Lactobacillus decreased significantly(P<0.05), and the decrease was more significant in the experimental group compared to the control group(P<0.05), while E.coli and Staphylococcus were much higher than the preoperative level(P<0.05), which was more significant in the control group. The incidence of postoperative infection was 9.1%(3/33) in the experimental group, which was significantly lower than  29.6%(8/27) in the control group(P<0.05).


CONCLUSIONS
Fast bowel preparation is effective in reducing gut flora disturbance and the incidence of postoperative infection.
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ying-jun
YJ
Wu
Cheng-tang
CT
Wu
Xiao-bin
XB
Zhang
Wen-tao
WT
Ou
Peng
P
Huang
D015179:Colorectal Neoplasms / Q000382:microbiology* / Q000601:surgery; D013505:Digestive System Surgical Procedures; D004733:Enema / Q000379:methods*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D064307:Microbiota; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D011446:Prospective Studies