Effect of ionic liquid on activity, stability, and structure of enzymes: a review.
Ionic liquids have shown their potential as a solvent media for many enzymatic reactions as well as protein preservation, because of their unusual characteristics. It is also observed that change in cation or anion alters the physiochemical properties of the ionic liquids, which in turn influence the enzymatic reactions by altering the structure, activity, enatioselectivity, and stability of the enzymes. Thus, it is utmost need of the researchers to have full understanding of these influences created by ionic liquids before choosing or developing an ionic liquid to serve as solvent media for enzymatic reaction or protein preservation. So, in the present review, we try to shed light on effects of ionic liquids chemistry on structure, stability, and activity of enzymes, which will be helpful for the researchers in various biocatalytic applications.
Advanced Materials Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mu
M
Naushad
Zied Abdullah
ZA
Alothman
Abbul Bashar
AB
Khan
Maroof
M
Ali
D000818:Animals; D055598:Chemical Phenomena; D004795:Enzyme Stability / Q000187:drug effects; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation / Q000187:drug effects
D004798:Enzymes; D052578:Ionic Liquids