Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo.
Longitudinal relaxation time in the rotating frame (T1ρ) was measured using continuous wave irradiation in normal and infarcted mouse myocardium in vivo. Significant increase in T1ρ was found after 7 days of infarction when compared with reference myocardium or in myocardium before infarction. Cine MRI and histology were performed to verify the severity of infarction. The time course of T1ρ in the infarct fits better with granulation and scar tissue formation than necrosis and edema. The results of the study show that T1ρ could potentially be a noninvasive quantitative marker for tissue remodeling after ischemic damage.
Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Haja-Sherief N
HS
Musthafa
Galina
G
Dragneva
Line
L
Lottonen
Mari
M
Merentie
Lyubomir
L
Petrov
Tommi
T
Heikura
Elias
E
Ylä-Herttuala
Seppo
S
Ylä-Herttuala
Olli
O
Gröhn
Timo
T
Liimatainen
D000465:Algorithms; D000818:Animals; D005260:Female; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008137:Longitudinal Studies; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D054084:Myocardial Bridging / Q000209:etiology / Q000473:pathology*; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D013382:Subtraction Technique