Meta-analysis of laparoscopic versus open colorectal surgery within fast-track perioperative care.
BACKGROUND
Both laparoscopic surgery and fast-track perioperative care have demonstrated advantages in patients undergoing elective colorectal resections. It is unclear whether there is an additive effect by combining these 2 procedures.


OBJECTIVE
The study aimed to conduct a meta-analysis of the randomized evidence to compare laparoscopic with open colorectal surgery within fast-track perioperative care.


METHODS
PubMed, MEDLINE, Embase, and the Cochrane library databases were electronically searched (January 1985 to August 2011).


METHODS
Randomized clinical trials compared laparoscopic with open colorectal resections within fast-track programs.


METHODS
Investigators independently reviewed articles, extracted data, and assessed study quality according to standardized criteria.


METHODS
The main outcomes measured were postoperative hospital stay, overall hospital stay, readmission rate, morbidity, and mortality.


RESULTS
Three trials were considered suitable for meta-analysis. A total of 171 patients underwent laparoscopic surgery, and 142 had open surgery. Meta-analysis showed that laparoscopic colorectal surgery had shorter postoperative hospital stays (weighted mean difference -1.06; 95% CI, -2.06 to -0.06, z = 2.08, p = 0.04) and shorter overall hospital stays (weighted mean difference -2.04; 95% CI, -3.50 to -0.58, z = 2.74, p < 0.01). No significant differences were noted for readmission rate (OR 0.54; 95% CI, 0.26-1.12, z = 1.65, p = 0.10), morbidity (OR 0.68; 95% CI, 0.42-1.10, z =1.58, p = 0.11), and mortality (OR 0.33; 95% CI, 0.09-1.18, z =1.70, p = 0.09). No publication bias and no significant heterogeneity were noted.


CONCLUSIONS
This study was limited because of its small sample size.


CONCLUSIONS
Laparoscopic colorectal surgery has shorter postoperative hospital stays and overall hospital stays than open surgery within fast-track perioperative care. There is no significant difference with respect to readmission rate, morbidity, and mortality. Because the number of patients included in the present trials was small, further studies should be undertaken to confirm these findings.
Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ming-zhe
MZ
Li
Long-bin
LB
Xiao
Wen-hui
WH
Wu
Shi-bin
SB
Yang
Shou-zhi
SZ
Li
D003107:Colorectal Surgery / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay / Q000706:statistics & numerical data; D009017:Morbidity; D009026:Mortality; D017063:Outcome Assessment, Health Care; D010359:Patient Readmission / Q000706:statistics & numerical data; D019990:Perioperative Care; D016032:Randomized Controlled Trials as Topic