Chronological and morphological study of heart development in the rat.
Adult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice.
Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez, México.
Salazar García
SG
Marcela
Revilla Monsalve María
RM
Cristina
Palomino Garibay Miguel
PG
Angel
Arteaga Martínez
AM
Manuel
Díaz-Cintra
DC
Sofía
De La Rosa-Santander
de LR
Patricia
Roque-Ramírez
RR
Bladimir
Sánchez Gómez
SG
Concepción
D000818:Animals; D000831:Animals, Newborn; D002642:Chick Embryo; D047108:Embryonic Development; D006321:Heart / Q000033:anatomy & histology* / Q000196:embryology*; D006801:Humans; D051379:Mice; D038081:Organogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley