Biocompatible poly(L-lactide)/MWCNT nanocomposites: morphological characterization, electrical properties, and stem cell interaction.
The promising perspectives of PLLA-based nanostructured biomaterials and their relevance in tissue engineering are reported. Nanocomposites based on PLLA and MWCNTs are developed with an MWCNT content ranging from 0 to 3 wt%. The electrical properties show a percolation threshold within a range of 0.21-0.33 wt% MWCNTs, and the conductivity increases by six orders of magnitude. The surface structure shows changes with the carbon nanotube concentration. The functional role of MWCNTs incorporation in terms of interactions with adult stem cells suggests that PLLA/MWCNT nanocomposites are suitable substrates for primary stem cell culture.
Department of Mining-Metallurgy and Materials Science School of Engineering, University of the Basque Country (EHU-UPV), Bilbao, Spain.
Erlantz
E
Lizundia
Jòsè Ramon
JR
Sarasua
Francesco
F
D'Angelo
Aldo
A
Orlacchio
Sabata
S
Martino
Josè Maria
JM
Kenny
Ilaria
I
Armentano
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D053687:Adult Stem Cells / Q000166:cytology / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004553:Electric Conductivity; D005455:Fluorescent Antibody Technique; D006801:Humans; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D061251:Primary Cell Culture; D013499:Surface Properties; D023822:Tissue Engineering
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D011091:Polyesters; C033616:poly(lactide)