HIV-associated opportunistic infections of the CNS.
Survival in people infected with HIV has improved because of an increasingly powerful array of antiretroviral treatments, but neurological symptoms due to comorbid conditions, including infection with hepatitis C virus, malnutrition, and the effects of accelerated cardiovascular disease and ageing, are increasingly salient. A therapeutic gap seems to exist between the salutary effects of antiretroviral regimens and the normalisation of neurological function in HIV-associated neurocognitive disorders. Despite the advances in antiretroviral therapy, CNS opportunistic infections remain a serious burden worldwide. Most opportunistic infections can be recognised by a combination of characteristic clinical and radiological features and are treatable, but some important challenges remain in the diagnosis and management of HIV-associated opportunistic infections.
HIV Neuroscience Program, Johns Hopkins University, Baltimore, MD 21287, USA.
Ik Lin
IL
Tan
Bryan R
BR
Smith
Gloria
G
von Geldern
Farrah J
FJ
Mateen
Justin C
JC
McArthur
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002494:Central Nervous System Infections / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans
D000890:Anti-Infective Agents