Neurological disorders: towards a mechanistic understanding of restless legs syndrome.
Restless legs syndrome is a curious neurological disorder of unknown aetiology. A new study has found that Drosophila mutants in the fly homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs display important features of the syndrome.
Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Ave Campus Box 8108, St. Louis, MO 63110, USA. shawp@pcg.wustl.edu
Paul J
PJ
Shaw
Stephen P
SP
Duntley
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics*; D004298:Dopamine / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D012148:Restless Legs Syndrome / Q000235:genetics* / Q000503:physiopathology*; D012892:Sleep Deprivation / Q000235:genetics*
C575814:BTBD9 protein, Drosophila; D002352:Carrier Proteins; D029721:Drosophila Proteins; D007501:Iron; D004298:Dopamine