Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus.
Noroviruses (NoVs) are important pathogens causing epidemic acute gastroenteritis that affects millions of people worldwide. The protruding (P) domain of the NoV capsid protein, the surface antigen of NoV, forms a 24-mer subviral particle called the P particle that is an excellent candidate vaccine against NoVs. The P particles are easily produced in Escherichia coli, highly stable and highly immunogenic. Each P domain has three surface loops that can be used for foreign antigen presentation, making the P particles a useful platform for vaccine development against other infectious diseases. This article summarizes the discovery, structure, development and applications of the P particles as a vaccine against NoVs, as well as a vaccine platform against rotavirus, influenza virus and possibly other pathogens in the future.
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA.
Ming
M
Tan
Xi
X
Jiang
D000818:Animals; D017250:Caliciviridae Infections / Q000276:immunology / Q000517:prevention & control*; D036022:Capsid Proteins / Q000737:chemistry / Q000276:immunology*; D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry; D029322:Norovirus / Q000737:chemistry / Q000276:immunology*; D009975:Orthomyxoviridae / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control; D017434:Protein Structure, Tertiary; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control; D014765:Viral Vaccines / Q000737:chemistry / Q000276:immunology*
D036022:Capsid Proteins; D014765:Viral Vaccines