Renal sympathetic nerve activity is increased in monosodium glutamate induced hyperadipose rats.
The literature suggests that both obesity and hypertension are associated with increased sympathetic nerve activity. In the present study we evaluated the renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) in hyperadipose rats induced by neonatal administration of monosodium glutamate (MSG). Neonatal Wistar male rats were injected with MSG (4 mg/g body weight ID) or equimolar saline (control) for 5 days. At 90th day, all rats were anesthetized (urethane 1.4 g/kg) and prepared for MAP, HR and renal sympathetic nerve activity recordings. The anesthetized MSG rats presented baseline hypertension and increased baseline RSNA compared with control. Our results suggest the involvement of the renal sympathetic nervous system in the physiopathology of the MSG obesity.
Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil.
Alexandro Márcio
AM
da Silva Mattos
Carlos Henrique
CH
Xavier
Marlusa
M
Karlen-Amarante
Natália Veronez
NV
da Cunha
Marco Antonio Peliky
MA
Fontes
Marli Cardoso
MC
Martins-Pinge
D050154:Adiposity; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D006339:Heart Rate; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D007668:Kidney / Q000294:innervation*; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D012970:Sodium Glutamate