[T-cell subpopulations and macrophages in stable and unstable coronary atherosclerotic plaques].
Unstable atherosclerotic plaques are a cause of acute myocardium infarction. Because peripheral blood mononuclear cells are often present in atherosclerotic plaques, we've examined T-cells (CD4, CD8) and macrophages (CD68) in the different areas of atherosclerotic plaques. The cells were counted individually in the center, shoulder at the bottom and in the cap of plaque. All types of studied cells prevailed in the unstable plaque cap than in the stable one (p < 0.05). CD4 and CD68 cells dominated in the shoulder of atherosclerotic plaque (p < 0.05). The difference between the numbers of macrophages at the bottom or in the center of stable and unstable plaques was statistically insignificant (p > 0.05). Prevalence of peripheral blood mononuclears in the cap and at the periphery of unstable plaques points their participation in the development of atherosclerotic plaque instability.
P V
PV
Chumachenko
E V
EV
Belokon'
R S
RS
Akchurin
V S
VS
Zhdanov
D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology*; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000473:pathology*