Radiosynthesis of carbon-11 labeled 6-methyldopamine ([¹¹C]MeDA).
A rapid and efficient n.c.a. radiosynthesis of 6-[(11)C]methyldopamine ([(11)C]MeDA) using the Stille cross-coupling reaction as a key step was developed. The labeling conditions for the formation of the intermediate compound (protected [(11)C]MeDA, [(11)C]7) were determined with respect to reaction temperature and time. The radiochemical yield 89 ± 1.4% (decay-corrected) of the protected intermediate [(11)C]7 was obtained at a reaction temperature of 60°C and a reaction time of 5 min using Pd(2)(dba)(3)/P(o-tolyl)(3) and CsF/CuBr as a co-catalyst system. The overall yield after deprotection with 45% HBr at 140°C for 10 min was 64 ± 3.9% (decay-corrected) within a total preparation time of 40 min, including hydrolysis, HPLC purification and formulation.
Clinic for Nuclear Medicine, University Ulm, Germany.
E
E
Al-Momani
B D
BD
Zlatopolskiy
H-J
HJ
Machulla
S N
SN
Reske
C
C
Solbach
D002250:Carbon Radioisotopes / Q000737:chemistry*; D003846:Deoxyepinephrine / Q000138:chemical synthesis*; D006358:Hot Temperature
D002250:Carbon Radioisotopes; D003846:Deoxyepinephrine