Chronic immune-mediated axonal polyneuropathy following umbilical cord blood transplant for childhood-onset cerebral adrenoleukodystrophy.
Peripheral polyneuropathy is an unusual complication after organ transplantation and HSCT. The present study describes the case of an eight-yr-old boy diagnosed with ALD who underwent HLA-matched UCBT under a reduced-intensity conditioning regimen and developed progressive walking difficulty and hand clumsiness 11 months after transplantation. These symptoms were associated with cGVHD, identified as immune-mediated axonopathy by electrophysiological examination and sural nerve biopsy. Peripheral polyneuropathy should be kept in mind as a complication of GVHD.
Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Minoru
M
Shibata
Takeo
T
Kato
Tomonari
T
Awaya
Souichi
S
Adachi
Toshio
T
Heike
D000326:Adrenoleukodystrophy / Q000628:therapy*; D001369:Axons / Q000473:pathology; D001706:Biopsy; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D004594:Electrophysiology / Q000379:methods; D005312:Fetal Blood / Q000166:cytology*; D006086:Graft vs Host Disease / Q000209:etiology / Q000473:pathology; D006801:Humans; D007107:Immune System; D008297:Male; D011115:Polyneuropathies / Q000209:etiology / Q000276:immunology*; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods