Uterine sarcomas: then and now.
OBJECTIVE
The purpose of this article is to provide an updated review of uterine sarcomas. The traditionally described neoplasms are reviewed as well as several recently characterized entities in terms of their imaging and clinical aspects. We attempt to provide a longitudinal imaging overview, from initial presentation to follow-up. Imaging features are also described of response to traditional therapeutic agents and newer targeted agents.


CONCLUSIONS
A greater understanding of the pathogenesis has improved our ability to image and treat uterine sarcomas, both at initial staging and on follow-up. Targeted therapy is assuming an increasingly important role in the management of these lesions. It is imperative for radiologists to be aware of response characteristics and potential complications of these agents as well as conventional chemotherapeutic agents.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 20 Chapel St. Unit B401, Brookline, MA 02446, USA. sshah18@partners.org
Shaan H
SH
Shah
Jyothi P
JP
Jagannathan
Katherine
K
Krajewski
Kevin N
KN
O'Regan
Suzanne
S
George
Nikhil H
NH
Ramaiya
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002296:Carcinosarcoma / Q000175:diagnosis / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology; D008137:Longitudinal Studies; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy; D009367:Neoplasm Staging; D010052:Ovariectomy; D011856:Radiographic Image Enhancement; D012509:Sarcoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*