A case of ANCA-associated vasculitis with glomerular eosinophilic infiltration: a possible pathogenic implication.
We present a 58-year-old male patient with myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with rapidly progressive glomerulonephritis. He failed to fulfill the common American College of Rheumatology criteria for eosinophilic granulomatosis with polyangiitis and was tentatively diagnosed with microscopic polyangiitis. Kidney biopsy showed pauci-immune crescentic necrotizing glomerulonephritis with neutrophilic and eosinophilic infiltration. Previous reports implicate eosinophils in the pathogenesis of this disease. Therefore, this case suggests that infiltrated eosinophils as well as neutrophils might play roles in the development of tissue injury in systemic vasculitis.
Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashiku, Tokyo 173-8610, Japan.
Hiroko
H
Suzuki
Takayuki
T
Fujita
Yoshinobu
Y
Fuke
Minako
M
Yabuki
Mamiko
M
Kajiwara
Yuko
Y
Ishihara
Seiichiro
S
Hemmi
Masayoshi
M
Soma
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology*; D005921:Glomerulonephritis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology*; D008297:Male; D055953:Microscopic Polyangiitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase