Newborn lamb as a new model for studying gastroesophageal reflux.
We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle-fed lambs, ages 2 to 3 days, underwent esophageal multichannel intraluminal impedance-pH monitoring (MII-pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acidic. No acid refluxes were observed. Median bolus clearance time was 4  seconds (3; 5.5), and proximal reflux extent was 35% (26). This first report of MII-pH in the newborn mammal sets the foundations for future studies with physiological and clinical relevance to human neonates.
Neonatal Respiratory Research Unit, Department of Pediatrics and Physiology, Université de Sherbrooke, Sherbrooke, Quebec, Canada. djamaldine.djeddi@usherbrooke.ca
Djamal
D
Djeddi
Nathalie
N
Samson
Nadia
N
Boudaa
Jean-Paul
JP
Praud
D000818:Animals; D000831:Animals, Newborn; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D005772:Gastrointestinal Transit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D007231:Infant, Newborn; D023421:Models, Animal; D015203:Reproducibility of Results; D012756:Sheep