Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial.
OBJECTIVE
Nutritional and vitamin status may be related to cognitive function and decline in older adults. The aim of this study was to investigate the effects of nutritional supplementation on cognition in older men.


METHODS
The current study was an 8-week, placebo-controlled, double-blind investigation into the effects of a multivitamin, mineral and herbal supplement (Swisse Men's Ultivite®, Swisse Vitamins Pty Ltd, Melbourne, Australia) on cognitive performance in older men. Participants were 51 male individuals aged between 50 and 74 years, with a sedentary lifestyle. Cognitive performance was assessed at baseline and post-treatment using a computerised battery of cognitive tasks, enabling the measurement of a range of attentional and memory processes. Blood measures of vitamin B(12) , folate and homocysteine were collected prior to and after supplementation.


RESULTS
The results of this study revealed that contextual recognition memory performance was significantly improved following multivitamin supplementation (p < 0.05). Performance on other cognitive tasks did not change. Levels of vitamin B(12) and folate were significantly increased with a concomitant decrease in homocysteine, indicating that relatively short-term supplementation with a multivitamin can benefit these risk factors for cognitive decline.


CONCLUSIONS
Findings from this study indicate that daily multivitamin supplementation may improve episodic memory in older men at risk of cognitive decline.
NICM Collaborative Centre for Neurocognition, Centre for Human Psychopharmacology, Swinburne University, Hawthorn, Victoria, Australia.
Elizabeth
E
Harris
Helen
H
Macpherson
Luis
L
Vitetta
Joni
J
Kirk
Avni
A
Sali
Andrew
A
Pipingas
D000368:Aged; D015415:Biomarkers / Q000097:blood; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D061212:Memory, Episodic; D008875:Middle Aged; D008903:Minerals / Q000008:administration & dosage / Q000494:pharmacology*; D009752:Nutritional Status; D008517:Phytotherapy / Q000379:methods*; D012307:Risk Factors; D057185:Sedentary Behavior; D014805:Vitamin B 12 / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D015415:Biomarkers; D008903:Minerals; D014815:Vitamins; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12