Good mass spectrometry and its place in good science.
The mass spectrometry community has expanded as instruments became more powerful, user-friendly, affordable and readily available. This opens up opportunities for novice users to perform high impact research, using highly advanced instrumentation. This introductory tutorial is targeted at the novice user working in a research setting. It aims to offer the benefit of other people's experiences and to help newcomers avoid known pitfalls and problematic issues. It discusses some of the essential features of sound analytical chemistry and highlights the need to use validated analytical methods that provide high quality results along with a measure of their uncertainty. Examples are used to illustrate potential pitfalls and their consequences.
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver-School of Medicine, Aurora, Colorado 80045, USA. mark.duncan@ucdenver.edu
Mark W
MW
Duncan
D013058:Mass Spectrometry / Q000379:methods* / Q000592:standards*; D040901:Proteomics / Q000379:methods* / Q000592:standards*; D015203:Reproducibility of Results; D012106:Research; D012680:Sensitivity and Specificity