One-pot multicomponent cascade reaction of N,S-ketene acetal: solvent-free synthesis of imidazo[1,2-a]thiochromeno[3,2-e]pyridines.
Unprecedented imidazo[1,2-a]thiochromeno[3,2-e]pyridines have been synthesized via a three-component cascade reaction under solvent-free conditions. This one-pot transformation involving multiple steps and not requiring the use of transition metal catalysts constructs three new C-C bonds, two C-N bonds, one C-S bond, and three new rings with all reactants efficiently utilized.
State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China. liming928@qust.edu.cn
Ming
M
Li
Han
H
Cao
Yong
Y
Wang
Xiu-Liang
XL
Lv
Li-Rong
LR
Wen
D000080:Acetals / Q000737:chemistry*; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D005030:Ethylenes / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D000080:Acetals; D002839:Chromans; D005030:Ethylenes; D007093:Imidazoles; D007659:Ketones; D011725:Pyridines; C576097:imidazo(1,2-a)thiochromeno(3,2-e)pyridine; C008223:ketene