Endocrine symptoms as the initial manifestation of Wilson's disease.
Wilson's disease is a rare genetic disorder of copper metabolism. The difference in copper tissue accumulation is responsible for the various clinical manifestations of this disorder. If left untreated, Wilson's disease progresses to hepatic failure, severe neurological disability, and even death. Due to the complex clinical picture of Wilson's disease, its diagnosis relies on a high index of suspicion. In our paper, we present endocrine symptoms suggesting the presence of insulinoma and hyperprolactinemia as the initial clinical manifestation of Wilson's disease in a young female. Zinc acetate treatment resulted in the disappearance of hypoglycemia, galactorrhea, and menstrual abnormalities.
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl
Robert
R
Krysiak
Gabriela
G
Handzlik-Orlik
Boguslaw
B
Okopien
D000568:Amenorrhea / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D005687:Galactorrhea / Q000175:diagnosis / Q000209:etiology; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006966:Hyperprolactinemia / Q000175:diagnosis* / Q000209:etiology; D007340:Insulinoma / Q000175:diagnosis* / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult; D019345:Zinc Acetate / Q000627:therapeutic use
D019345:Zinc Acetate