No association between PAWR gene polymorphisms and tardive dyskinesia in schizophrenia patients.
Tardive dyskinesia (TD) is a hyperkinetic movement disorder associated with the prolonged use of antipsychotic drugs. Since prostate apoptosis response 4 (Par-4) is a key ligand of the dopamine D2 receptor, the Par-4 gene (PAWR) is a good candidate gene to study in the context of TD susceptibility. We examined the association between PAWR gene polymorphisms and TD. Three single nucleotide polymorphisms of PAWR were selected for the analysis: rs7979987, rs4842318, and rs17005769. Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). Genotype/allele-wise and haplotype-wise analyses were performed. There were no significant differences in genotype and allele frequencies between the two groups. Haplotype analysis also did not reveal a difference between the two groups. Within the limitations imposed by the size of the clinical sample, these findings suggest that PAWR gene variants do not significantly contribute to an increased risk of TD.
Department of Psychiatry, Korea University School of Medicine, Seoul, Korea.
Il-Soo
IS
Kim
Ho-Kyoung
HK
Yoon
Seung-Gul
SG
Kang
Young-Min
YM
Park
Yong-Ku
YK
Kim
Seung-Hyun
SH
Kim
Jung-Eun
JE
Choi
Leen
L
Kim
Heon-Jeong
HJ
Lee