Systems and synthetic biology of the vessel wall.
Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.
Department of Bioengineering, Imperial College London, United Kingdom.
Jennifer
J
Frueh
Nataly
N
Maimari
Ying
Y
Lui
Zoltan
Z
Kis
Vikram
V
Mehta
Negin
N
Pormehr
Calum
C
Grant
Emmanuel
E
Chalkias
Mika
M
Falck-Hansen
Sandra
S
Bovens
Ryan
R
Pedrigi
Taka
T
Homma
Gianfillippo
G
Coppola
Rob
R
Krams
D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D001775:Blood Circulation / Q000235:genetics; D001808:Blood Vessels / Q000166:cytology* / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology; D003198:Computer Simulation; D042783:Endothelial Cells / Q000378:metabolism; D023281:Genomics; D021621:Imaging, Three-Dimensional; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D058615:Synthetic Biology / Q000379:methods*; D049490:Systems Biology / Q000379:methods*; D059467:Transcriptome
D051741:Kruppel-Like Transcription Factors; D016328:NF-kappa B