A movie of RNA polymerase II transcription.
We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.
Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Munich, Germany.
Alan C M
AC
Cheung
Patrick
P
Cramer
D001105:Archaea / Q000201:enzymology / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology / Q000378:metabolism; D005658:Fungi / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D009040:Motion Pictures; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic
D014157:Transcription Factors; D012319:RNA Polymerase II