A Peptide-Based Material for Therapeutic Carbon Monoxide Delivery.
We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.
Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, 60611, USA. ; Tel: (+312) 503-6713.
John B
JB
Matson
Matthew J
MJ
Webber
Vibha K
VK
Tamboli
Benjamin
B
Weber
Samuel I
SI
Stupp