Anesthesia, surgery, illness and Alzheimer's disease.
Patients and their families have, for many decades, detected subtle changes in cognition subsequent to surgery, and only recently has this been subjected to scientific scrutiny. Through a combination of retrospective human studies, small prospective biomarker studies, and experiments in animals, it is now clear that durable consequences of both anesthesia and surgery occur, and that these intersect with the normal processes of aging, and the abnormal processes of chronic neurodegeneration. It is highly likely that inflammatory cascades are at the heart of this intersection, and if confirmed, this suggests a therapeutic strategy to mitigate enhanced neuropathology in vulnerable surgical patients.
Department of Anesthesiology & Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: Roderic.Eckenhoff@uphs.upenn.edu.
Roderic G
RG
Eckenhoff
Krzysztof F
KF
Laudansky
D000544:Alzheimer Disease / Q000209:etiology*; D000758:Anesthesia / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D011183:Postoperative Complications / Q000503:physiopathology*