Aneuploidy and copy number variation in early human development.
Early human in vitro fertilized embryos frequently accumulate whole chromosome aneuploidies and segmental imbalances. This embryonic chromosomal instability does not necessarily undermine normal human development, but it may lead to loss of conception, genetic disease, and genetic variation development. In this review we provide an overview of how this instability of chromosomes arises and evolves during early human embryogenesis.
Laboratory for Cytogenetics and Genome Research, Center for Human Genetics, KU Leuven, UZ Gasthuisberg, Leuven, Belgium.
Evelyne
E
Vanneste
Niels
N
Van der Aa
Thierry
T
Voet
Joris Robert
JR
Vermeesch
D000782:Aneuploidy; D043171:Chromosomal Instability / Q000502:physiology*; D002869:Chromosome Aberrations / Q000196:embryology*; D056915:DNA Copy Number Variations / Q000502:physiology*; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy