Lifestyle behaviors associated with exposures to endocrine disruptors.
Identifying and characterizing sources of exposure to phthalates and bisphenol A (BPA) have proved challenging due to the presence of multiple co-exposures resulting from a wide variety of home environments and lifestyles. We hypothesized that the consistent lifestyle of an Old Order Mennonite (OOM) community would provide an ideal setting in which to characterize sources of exposure to BPA and phthalates. We obtained urine samples from ten mid-term pregnant OOM women (ages-21-39) to determine concentrations of 9 phthalate metabolites and BPA and collected a self-reported survey of participants' household environment, product use, and lifestyle within a 48-h period prior to urine collection. We compared their metabolite concentrations to pregnant women included in the National Health and Nutrition Examination Survey (NHANES 2007-2008). Although OOM participants reported some use of plastic and fragranced household products, concentrations of metabolites were lower and significantly less for BPA (p=0.002) and phthalate metabolites MEHP (p=0.0215), MiBP (p=0.0020) and MEP (p=0.021), when compared to NHANES pregnant women. Levels of other phthalate metabolites were also lower in this population. Our data suggest three practices that may contribute to these lower levels: (1) consuming mostly homegrown produce (ingestion), (2) no cosmetics and limited use of personal care products, and (3) transportation primarily by sources other than automobiles.
Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester, 265 Crittenden Blvd., CU 420644, Rochester, NY 14642-0644, USA. Electronic address: Camille_Martina@urmc.rochester.edu.
Camille A
CA
Martina
Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA. Electronic address: bernard_weiss@urmc.rochester.edu.
Bernard
B
Weiss
Department of Preventive Medicine, Mount Sinai Medical Center, 1 Gustave L. Levy Place (Box 1057), New York, NY 10029, USA. Electronic address: shanna.swan@mssm.edu.
Shanna H
SH
Swan
D000328:Adult; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000652:urine; D015415:Biomarkers / Q000652:urine; D001711:Biotransformation; D003358:Cosmetics / Q000009:adverse effects; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000652:urine; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006795:Household Products / Q000009:adverse effects; D006801:Humans; D006920:Hygiene; D008019:Life Style; D010636:Phenols / Q000009:adverse effects* / Q000652:urine; D010795:Phthalic Acids / Q000009:adverse effects* / Q000652:urine; D011247:Pregnancy; D033303:Protestantism; D011795:Surveys and Questionnaires; D013997:Time Factors; D014186:Transportation; D055815:Young Adult; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D015415:Biomarkers; D003358:Cosmetics; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds