Studies on the function and regulation of mitochondrial uncoupling proteins.
Mitochondrial uncoupling proteins are members of the SLC25 family of solute carriers. Models of mitochondrial transporter function predict that uncoupling proteins are solute carriers. Evidence in the literature suggests that uncoupling proteins can transport protons, fatty acid anions, chloride anions, and recently the dicarboxylate succinate. Studies have also demonstrated that UCPs can be covalently modified and in some instances this covalent modification is needed to affect uncoupling function. The current evidence from functional analyses of mammalian uncoupling proteins is summarized in this chapter.
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. rkporter@tcd.ie
Richard K
RK
Porter
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000032:analysis / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000032:analysis / Q000502:physiology*; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
D007473:Ion Channels; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3