How viruses affect the cell cycle through manipulation of the APC/C.
Viruses frequently exploit host cell cycle machineries for their own benefit, often by targeting 'master switches' of cell cycle regulation. By doing so, they achieve maximum effect from minimal input. One such master switch is the anaphase promoting complex or cyclosome (APC/C), a multicomponent ubiquitin ligase and a dominant regulator of the cell cycle. A growing number of viruses have been shown to target the APC/C. Although differing strategies are employed, viral manipulation of the APC/C seems to serve a common purpose, namely, to create an environment supportive of viral replication. Here, the molecular mechanisms employed by these viruses are summarized and discussed.
Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9016, New Zealand.
Min
M
Mo
Saleha
S
Shahar
Stephen B
SB
Fleming
Andrew A
AA
Mercer
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*; D014780:Viruses / Q000378:metabolism*
D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome