Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma.
OBJECTIVE
To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).


METHODS
A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed.


RESULTS
Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001).


CONCLUSIONS
High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.
Center of Therapeutic Research for Liver Cancer, The 302nd Hospital, Beijing 100039, China.
Jian-Hui
JH
Qu
Xiu-Juan
XJ
Chang
Yin-Ying
YY
Lu
Wen-Lin
WL
Bai
Yan
Y
Chen
Lin
L
Zhou
Zhen
Z
Zeng
Chun-Ping
CP
Wang
Lin-Jing
LJ
An
Li-Yan
LY
Hao
Gui-Lin
GL
Xu
Xu-Dong
XD
Gao
Min
M
Lou
Ji-Yun
JY
Lv
Yong-Ping
YP
Yang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D012189:Retrospective Studies; D016019:Survival Analysis; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*; D055815:Young Adult
D014408:Biomarkers, Tumor; C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D019859:Proto-Oncogene Proteins c-met