IRGM gene polymorphisms and risk of gastric cancer.
OBJECTIVE
The study aimed to assess the possible association of polymorphisms in the autophagy gene IRGM (rs13361189 and rs4958847) with the risk of gastric cancer.


METHODS
A total of 102 patients with gastric adenocarcinoma, 52 with chronic gastritis and 351 healthy controls were included in this study. IRGM allelic variants were genotyped by quantitative real-time polymerase chain reaction. The association between polymorphisms and gastric cancer risk was estimated by odds ratios (OR) and 95% confidence interval (CI).


RESULTS
A significant difference was found for rs4958847 A allele. Carriers of the A allele were protected against gastric cancer (OR = 0.58, 95% CI 0.35-0.97, P = 0.038). Moreover, the presence of this allele seems to play an important role in decreasing the risk for the intestinal type of gastric cancer (OR = 0.47, 95% CI 0.23-0.94, P = 0.03). In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer. None of the targeted polymorphisms were associated with chronic gastritis.


CONCLUSIONS
IRGM rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type.
Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy from Craiova, Craiova, Romania.
Florin
F
Burada
Theo S
TS
Plantinga
Mihai
M
Ioana
Diana
D
Rosentul
Cristina
C
Angelescu
Leo A
LA
Joosten
Mihai G
MG
Netea
Adrian
A
Saftoiu
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D001343:Autophagy / Q000235:genetics; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005756:Gastritis / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D009363:Neoplasm Proteins; D019204:GTP-Binding Proteins; C513539:IRGM protein, human