Correlation of cardiorespiratory fitness with risk factors for cardiovascular disease in children with type 1 diabetes mellitus.
The objective of this study was to correlate CRF with cardiovascular risk factors in T1DM children.


METHODS
Fifty children and adolescents aged between 9 and 17 years with no diabetes complications and a mean diabetes duration of 4.6 years were selected. Antropometric, sexual maturation and blood pressure data were evaluated. CRF level was assessed with a 20-m shuttle run test. Laboratory tests were performed to verify fasting lipids and glycated hemoglobin. Statistical analyses were made with Pearson partial correlation, t test, and one-way ANOVA, with p≤0.05.


RESULTS
After adjustment for body adiposity and sexual maturity, inverse correlations among CRF and TC, TG, TC/HDL-C, TG/HDL-C, non-HDL-C, and SBP were statistically significant. Variables differing by sex included weight Z score, BMI Z score, skinfold thickness, percentage of body fat, and DBP. Boys had higher CRF compared to girls. CRF and TC differed significantly by sexual maturation status.


CONCLUSIONS
An inverse and significant relationship between CRF and most lipid profile's components and SBP in poor controlled T1DM children and adolescents was found, independently of body adiposity.
Physical Education Departament, Federal University of Paraná, Curitiba, PR 80215-370, Brazil. crispetra@uol.com.br
Cristiane P
CP
Miculis
Wagner
W
de Campos
Guilherme S
GS
Gasparotto
Michael P
MP
Silva
Luis P
LP
Mascarenhas
Margaret C S
MC
Boguszewski
D000293:Adolescent; D041923:Adolescent Development; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D002319:Cardiovascular System / Q000503:physiopathology*; D002648:Child; D002657:Child Development; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D010809:Physical Fitness; D012137:Respiratory System / Q000503:physiopathology*; D012307:Risk Factors; D012727:Sex Characteristics
D006442:Glycated Hemoglobin; D008055:Lipids; C517652:hemoglobin A1c protein, human