Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.
The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Mohannad
M
Abdo
Stephen P
SP
Brown
Joel R
JR
Courter
Matthew J
MJ
Tucker
Robin M
RM
Hochstrasser
Amos B
AB
Smith
D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D055668:Photochemical Processes; D013777:Tetrazoles / Q000737:chemistry*
D010455:Peptides; D013777:Tetrazoles