Human atrial fibrillation: insights from computational electrophysiological models.
Computational electrophysiology has proven useful to investigate the mechanisms of cardiac arrhythmias at various spatial scales, from isolated myocytes to the whole heart. This article reviews how mathematical modeling has aided our understanding of human atrial myocyte electrophysiology to study the contribution of structural and electrical remodeling to human atrial fibrillation. Potential new avenues of investigation and model development are suggested.
Department of Pharmacology, University of California at Davis, Davis, CA 95616-8636, USA. dmbers@ucdavis.edu
Donald M
DM
Bers
Eleonora
E
Grandi
D001281:Atrial Fibrillation / Q000503:physiopathology*; D003198:Computer Simulation; D004594:Electrophysiology; D006801:Humans; D015398:Signal Transduction / Q000502:physiology