Sudden loss of milk supply following high-dose triamcinolone (Kenacort) injection.
Endogenous corticosteroids are involved in breast development, initiation and maintenance of milk production. Animal studies have shown that exogenous corticosteroids diminish milk production and milk ejection. A high dose depot injection of triamcinolone resulted in dramatic reduction in milk production in an established lactation. Domperidone and frequent expression restored milk production. Lower dose depot injection of betamethasone into the shoulder joint did not noticeably reduce milk production.
Lactation Resource Centre.
Elizabeth
E
McGuire
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects*; D007775:Lactation Disorders / Q000139:chemically induced* / Q000517:prevention & control; D008425:Maternal Behavior / Q000187:drug effects; D008893:Milk Ejection / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects*; D012678:Sensation Disorders / Q000188:drug therapy; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects*
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide