Variants in the SRD5A2 gene are associated with quality of semen.
Spermatogenesis and sperm maturation are androgen-dependent processes. Steroid             5α-reductase (SRD5A) is a key enzyme converting testosterone into the more active             metabolite, dihydrotestosterone (DHT). We aimed to investigate the association             between the genetic variants of SRD5A2 (rs4952197, rs2268797, rs13395648, rs523349             and rs632148) and semen quality. Variant genotyping and semen analysis was performed             in 708 males with definite idiopathic infertility by TaqMan SNP genotyping assays             and computer-assisted semen analysis, respectively. It was found that the rs13395648             TC genotype was associated with a significantly lower semen volume compared with             the TT genotype (P=0.016). The same trend was found between the combination of             the TC and CC genotypes and the TT genotype (P=0.020). With regard to variant             rs632148, subjects with the GC genotype had significantly lower sperm motility             in comparison to those with the GG genotype (P=0.029). The sperm motility between             the combination of the GC and CC genotypes and the GC genotype was also significantly             different (P=0.033). These findings indicate that genetic variants in the SRD5A2             gene may be associated with semen quality.
State Key Laboratory of Reproductive Medicine, Department of Urology, First Affiliated Hospital of Nanjing Medical University, and School of Public Health, Nanjing Medical University, Nanjing 210029, PR China.
Dan
D
Zhao
Wei
W
Wu
Bin
B
Xu
Xiaobing
X
Niu
Hongxing
H
Cui
Yi
Y
Zhang
Zengjun
Z
Wang
Xinru
X
Wang
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000465:Algorithms; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012661:Semen / Q000166:cytology / Q000378:metabolism*; D055101:Semen Analysis; D012984:Software; D013081:Sperm Motility
D008565:Membrane Proteins; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; C548468:SRD5A2 protein, human