Chronic liver inflammation dominated by interferon-γ can prevent hepatocarcinogenesis.
Inflammation is a major stimulus for carcinogenesis; however inflammation can also inhibit tumor growth and deplete malignant cells. The differences between cancer-promoting and cancer-inhibitory inflammation are not clear. We identified Interferon-γ as a major mediator of cancer-inhibitory inflammation that promotes anti-cancer immunity in the liver and sensitizes malignant hepatocytes for apoptosis.
Department of Medicine I; University Medical Centre Hamburg-Eppendorf; Hamburg, Germany.
Jörg
J
Schrader
Johannes
J
Herkel