Photo-responsive interpenetrating network beads of alginate/polyvinyl alcohol-coumarin conjugate.
Interpenetrating network (IPN) beads composed of alginate and poly(vinyl alcohol)-epoxypropoxy coumarin (PVA-EPC) conjugate were prepared by dropping the mixture solution into CaCl2 solution under UV irradiation (λ = 365 nm). EPC residues of PVA-EPC could readily be dimerized by λ = 365 nm and de-dimerized by λ= 254 nm even in the presence of alginate. In addition, the viscosity of the mixture solution increased with the time of UV irradiation due to the photo-dimerization. The percentage release in 360 min of FITC-dextran loaded in the beads, which were prepared using the mixture solutions of which alginate/PVA-EPC concentrations were 0.5%/0.5%, 0.5%/1%, and 0.5%/2.5%, were about 2%, 11%, and 5%, respectively. Interestingly, in case of beads prepared using the mixture solution of which alginate/PVA-EPC concentration was 0.5%/2.5%, the release was a little but significantly promoted by the irradiation of λ= 254 nm.
College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University , Hyoja 2 dong, Chunchon, Kangwon-do , Korea.
Seung Ree
SR
Seo
Jin-Chul
JC
Kim
D000464:Alginates / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D019281:Dimerization; D004339:Drug Compounding; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013997:Time Factors; D014466:Ultraviolet Rays; D014783:Viscosity
D000464:Alginates; D003374:Coumarins; D003911:Dextrans; D006603:Hexuronic Acids; C015219:fluorescein isothiocyanate dextran; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; C030123:coumarin; D016650:Fluorescein-5-isothiocyanate; D002122:Calcium Chloride