Age-related changes in the response of intestinal cells to 1α,25(OH)2-vitamin D3.
The hormonally active form of vitamin D(3), 1α,25(OH)(2)-vitamin D(3), acts in intestine, its major target tissue, where its actions are of regulatory and developmental importance: regulation of intracellular calcium through modulation of second messengers and activation of mitogenic cascades leading to cell proliferation. Several causes have been postulated to modify the hormone response in intestinal cells with ageing, among them, alterations of vitamin D receptor (VDR) levels and binding sites, reduced expression of G-proteins and hormone signal transduction changes. The current review summarizes the actual knowledge regarding the molecular and biochemical basis of age-impaired 1α,25(OH)(2)-vitamin D(3) receptor-mediated signaling in intestinal cells. A fundamental understanding why the hormone functions are impaired with age will enhance our knowledge of its importance in intestinal cell physiology.
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Consejo Nacional de Investigaciones Científicas y Técnicas, Bahía Blanca, Argentina.
Verónica
V
Gonzalez Pardo
Ana
A
Russo de Boland
D000375:Aging / Q000502:physiology*; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology*; D002120:Calcium Channel Agonists / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation; D020895:Enterocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010739:Phospholipase D / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology; D018167:Receptors, Calcitriol / Q000187:drug effects / Q000378:metabolism; D054507:Receptors, Phospholipase A2 / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014815:Vitamins / Q000494:pharmacology*; D019061:src-Family Kinases / Q000378:metabolism
D002120:Calcium Channel Agonists; D018167:Receptors, Calcitriol; D054507:Receptors, Phospholipase A2; D014815:Vitamins; D019869:Phosphatidylinositol 3-Kinases; D019061:src-Family Kinases; D020928:Mitogen-Activated Protein Kinases; D017027:Protein Tyrosine Phosphatases; D010739:Phospholipase D; D002117:Calcitriol