Design, synthesis and antiviral potential of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes using an efficient polymer-supported catalyst.
Polyethyleneglycol bound sulfonic acid (PEG-OSO₃H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biological properties of these synthesized title compounds revealed that compounds 3b, 3c, 3f and 3i showed highly significant anti-viral activity against tobacco mosaic virus.
Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Kalla
K
Reddi Mohan Naidu
Balam
B
Satheesh Krishna
Mungara
M
Anil Kumar
Palanisamy
P
Arulselvan
Shaik
S
Ibrahim Khalivulla
Ola
O
Lasekan
D000447:Aldehydes / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D009284:Naphthols / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D014027:Tobacco Mosaic Virus / Q000187:drug effects; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000447:Aldehydes; D000998:Antiviral Agents; D009284:Naphthols; D011108:Polymers; D014966:Xanthenes; D011092:Polyethylene Glycols; C028405:2-naphthol