A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood.
BACKGROUND
Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause.


METHODS
We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35 years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN.


CONCLUSIONS
This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
Kenji
K
Tsuji
Haruhito Adam
HA
Uchida
Tetsuichirou
T
Ono
Tatsuyuki
T
Inoue
Katsuji
K
Shinagawa
Shinji
S
Kitamura
Yohei
Y
Maeshima
Hitoshi
H
Sugiyama
Hirofumi
H
Makino
D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D016896:Treatment Outcome