Quantitative spectroscopic photoacoustic imaging: a review.
Obtaining absolute chromophore concentrations from photoacoustic images obtained at multiple wavelengths is a nontrivial aspect of photoacoustic imaging but is essential for accurate functional and molecular imaging. This topic, known as quantitative photoacoustic imaging, is reviewed here. The inverse problems involved are described, their nature (nonlinear and ill-posed) is discussed, proposed solution techniques and their limitations are explained, and the remaining unsolved challenges are introduced.
University College London, Department of Medical Physics and Bioengineering, Gower Street, London WC1E 6BT, United Kingdom. b.cox@ucl.ac.uk
Ben
B
Cox
Jan G
JG
Laufer
Simon R
SR
Arridge
Paul C
PC
Beard
D000162:Acoustics; D000465:Algorithms; D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D008027:Light; D033401:Microscopy, Acoustic / Q000379:methods*; D015233:Models, Statistical; D057054:Molecular Imaging / Q000379:methods; D009010:Monte Carlo Method; D055095:Optics and Photonics; D010100:Oxygen / Q000378:metabolism; D061088:Photoacoustic Techniques / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000379:methods*
D010100:Oxygen