Tissue doppler echocardiography detects preclinical markers of cardiac lesion in MDS patients.
Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder of elderly people. Cardiac dysfunction is a marker of grim prognosis in MDS. We evaluated cardiac dysfunction of MDS patients with or without transfusion dependency by tissue doppler echocardiography. We found the average values of ventricular end-systolic and end-diastolic volumes in transfusion dependency MDS group higher than others. These results were strongly correlated to hemoglobin levels. Tissue Doppler Echocardiography should be routinely performed in MDS patients to detect preclinical cardiac alterations and prevent more heart insults in this group of chronic anemic aged patients.
Post-Graduate Program of Pathology- Federal University of Ceará, Fortaleza, Brazil.
Cláudio César Monteiro
CC
de Castro
Carlos Bellini
CB
Gondim Gomes
Manoel Ricardo Alves
MR
Martins
Juliana Cordeiro
JC
de Sousa
Silvia M M
SM
Magalhaes
Ronald F
RF
Pinheiro
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000000981:diagnostic imaging* / Q000209:etiology; D015415:Biomarkers / Q000032:analysis*; D015150:Echocardiography, Doppler; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011379:Prognosis; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
D015415:Biomarkers; D006454:Hemoglobins