Emergence of nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension.
Multi drug resistance and non specific targeting is a major problem with conventional therapy. To overcome this problem, nanoparticles (NPs) have emerged as an important tool to deliver conventional drugs, recombinant proteins, vaccines and more recently, nucleotides. NPs modify the drug release pattern, absorption, distribution, metabolism, excretion (ADME) and therapeutic response. This review focuses on the potential of nanotechnology in cancer and discusses the different nanoparticulate drug-delivery systems including quantum dot, iron oxide nanoparticles, gold nanoparticles, carbon nanotubes, silica nanoparticles, dendrimer, graphene and polymeric nanoparticles with their applications in therapeutics, diagnostics, and imaging pattern. Further, the recent development and progress of theranostic nanoparticles in the treatment of cancer and toxicity associated with nanoparticles is also covered here.
Dreamz College of Pharmacy, H.P., India. mahfoozkaifi@gmail.com
Mahfoozur
M
Rahman
Mohammad Zaki
MZ
Ahmad
Imran
I
Kazmi
Sohail
S
Akhter
Muhammad
M
Afzal
Gaurav
G
Gupta
Vivek Ranjan
VR
Sinha
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004337:Drug Carriers; D006801:Humans; D050997:Nanomedicine; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D004337:Drug Carriers