CD38 gene polymorphism and risk of chronic lymphocytic leukemia.
rs6449182 CD38 gene polymorphism was determined by polymerase chain reaction with restriction of products in 328 chronic lymphocytic leukemia (CLL) patients and 271 age- and sex-matched controls. An association between GG genotype and CLL risk was found in the whole group of patients (OR=2.12; p=0.009) and in patients with unmutated immunoglobulin heavy chain variable genes (OR=2.17; p=0.011) comparing to the controls. In the subgroup of 174 controls with evaluated lipids the genotype distributions in CLL patients and dyslipidemic controls were similar. An association between GG genotype and CLL risk was significant compared to controls without lipids' abnormalities (OR=3.92; p=0.006).
Department of Clinical Immunology, National Research Center for Radiation Medicine, National Academy of Medical Sciences, Kyiv, Ukraine. nbilous@yahoo.com
Iryna V
IV
Abramenko
Nadiia I
NI
Bilous
Gleb V
GV
Pleskach
Anatoliy A
AA
Chumak
Iryna A
IA
Kryachok
Zoya V
ZV
Martina
Iryna S
IS
Dyagil
D051997:ADP-ribosyl Cyclase 1 / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D004247:DNA; D051997:ADP-ribosyl Cyclase 1