Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation.
It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses.
Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.
Jonathan
J
Campbell
Joanne
J
Trgovcich
Michelle
M
Kincaid
Peter D
PD
Zimmerman
Paul
P
Klenerman
Stuart
S
Sims
Charles H
CH
Cook
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D007156:Immunologic Memory / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014775:Virus Activation / Q000276:immunology; D017735:Virus Latency / Q000276:immunology*
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides