Fluoroform-derived CuCF3 for low-cost, simple, efficient, and safe trifluoromethylation of aryl boronic acids in air.
Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF(3)  in DMF in non-dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional-group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield.
Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona, Spain.
Petr
P
Novák
Anton
A
Lishchynskyi
Vladimir V
VV
Grushin
D000388:Air; D001897:Boronic Acids / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D001897:Boronic Acids; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; C519478:trifluoromethylcopper