A flexible depth probe using liquid crystal polymer.
We proposed a method of making a flexible depth-type neural probe using liquid crystal polymer. Conventional depth neural probes made of metal or silicon have the limitations of a single recording site per shank or the brittleness of the silicon substrate. To avoid these drawbacks, polymer-based depth neural probes have been developed with biocompatible polymers such as polyimides or parylenes. However, those have suffered from the difficulty of inserting the probes into brain tissues due to their high flexibility, requiring mechanical reinforcements. Herein, we report the first attempt to use a flexible material, liquid crystal polymer (LCP), as a substrate for a depth-type neural probe. The LCP-based probe offers a controllable stiffness vs. flexibility and compatibility with thin-film processes in addition to its inherent characteristics such as high reliability and biocompatibility. In the present study, an LCP neural probe was fabricated to have enough stiffness to penetrate the dura mater of rodent brains without a guide tool or additional reinforcement structures. A simultaneous multichannel neural recording was successfully achieved from the somatosensory motor cortex of the rodents. Immunohistochemistry showed that the electrodes could be inserted into the desired regions in the brain.
Department of Electrical Engineering and Computer Science, Inter-University Semiconductor Research Center, Seoul National University, Seoul, 151-744, Korea. shauon83@gmail.com
Sung Eun
SE
Lee
Sang Beom
SB
Jun
Hyun Joo
HJ
Lee
Jinhyung
J
Kim
Seung Woo
SW
Lee
Changkyun
C
Im
Hyung-Cheul
HC
Shin
Jin Woo
JW
Chang
Sung June
SJ
Kim
D000818:Animals; D001921:Brain / Q000502:physiology* / Q000601:surgery*; D004567:Electrodes, Implanted; D009474:Neurons / Q000502:physiology*; D019635:Neurosurgical Procedures / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012815:Signal Processing, Computer-Assisted; D012825:Silicon / Q000737:chemistry
D011108:Polymers; C422409:liquid crystal polymer; D012825:Silicon