Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles.
BACKGROUND
Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.


RESULTS
Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.


CONCLUSIONS
The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.
Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. banik@utpa.edu.
Rosario Astrid Vargas
RA
Cárdenas
Blanca Olinda Quintanilla
BO
Leal
Ashwini
A
Reddy
Debasish
D
Bandyopadhyay
Bimal K
BK
Banik