A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: synthesis of 4-bromoisoquinolones.
A method for synthesis of 4-bromoisoquinolones has been developed starting from 2-alkynylbenzaldehydes and primary amines mediated by CuBr under an O(2) atmosphere, where CuBr plays multiple roles to facilitate the present reactions.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Pei Chui
PC
Too
Shunsuke
S
Chiba
D000588:Amines / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry
D000588:Amines; D001547:Benzaldehydes; D001965:Bromides; D007546:Isoquinolines; C408079:cupric bromide; D003300:Copper; D010100:Oxygen