Development and characteristics of children with Usher syndrome and CHARGE syndrome.
OBJECTIVE
Individuals with Usher syndrome or CHARGE syndrome are faced with a number of difficulties concerning hearing, vision, balance, and language development. The aim of the study is to describe the developmental characteristics of children with Usher syndrome and CHARGE syndrome, respectively.


METHODS
Data about the developmental characteristics of 26 children with Usher syndrome and 17 children with CHARGE syndrome was obtained. Associations between deafblindness (dual sensory loss), motor development (age of walking), language abilities, and intellectual outcome of these children were explored for each group independently.


RESULTS
Both groups of children face a number of difficulties associated with vision, hearing, language, balance and intellectual outcome. Intellectual disability and/or language delay was found among 42% of the children with Usher syndrome and among 82% of the children with CHARGE syndrome. Intellectual disability was associated with language delay and age of walking for both groups.


CONCLUSIONS
Even though Usher and CHARGE are two different genetic syndromes, both groups are challenged with a number of similar developmental delays. Clinicians need to be aware of several developmental issues in order to offer adequate support to children with Usher or CHARGE syndrome.
University of Copenhagen, Department of Psychology, Denmark. jesper.dammeyer@psy.ku.dk
Jesper
J
Dammeyer
D000293:Adolescent; D058747:CHARGE Syndrome / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology*; D004185:Disability Evaluation; D005260:Female; D006320:Hearing Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology*; D007804:Language Development; D007805:Language Development Disorders / Q000209:etiology; D008297:Male; D052245:Usher Syndromes / Q000503:physiopathology / Q000523:psychology