Malignant pleural mesothelioma: from the bench to the bedside.
Optimal management of malignant pleural mesothelioma (MPM), which is mainly based on patient characteristics and clinical stage, is not clearly defined yet, although detailed, practical guidelines for these patients have been proposed by some scientific societies. Translational research, in the field of this disease, is currently in progress and different molecular oncogenic pathways leading to the growth and progression of MPM have been characterized with recent pharmaceutical developments. However, further in-depth analysis still needs to be done for a more advanced deciphering of the step-by-step process leading from early increased mesothelial cell proliferation to invasive mesothelioma, from which we are expecting the development of definitively effective therapy. Thus, this review is an overview of the recent advances in the biology of MPM and their potential therapeutic applications in the field of MPM diagnosis and treatment.
Department of Thoracic Oncology, Pleural Diseases and Interventional Pulmonology, Hôpital Nord, Marseille, France. philippejean.astoul@ap-hm.fr
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P
Astoul
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Roca
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F
Galateau-Salle
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A
Scherpereel
D014408:Biomarkers, Tumor; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D018919:Neovascularization, Physiologic / Q000502:physiology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000502:physiology; D020239:Receptor Cross-Talk / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor / Q000502:physiology; D057170:Translational Research, Biomedical
D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; C498780:IGF2BP3 protein, human; D016601:RNA-Binding Proteins; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor