Obesity and metabolic syndrome: an inflammatory condition.
Obesity causes chronic low-grade inflammation that contributes to systemic metabolic dysfunction associated with obesity-linked disorders that fall under the definition of metabolic syndrome. Adipose tissue is a key endocrine organ as it releases multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have proinflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this emerging context, the gut microbiota-metabolism interactions play an increasingly important role in the understanding and hopefully future treatment of complex metabolic unbalances responsible for insulin resistance and cardiovascular high-risk diseases.
Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Belgium.
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Scarpellini
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Tack
D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications* / Q000473:pathology*; D009765:Obesity / Q000150:complications* / Q000473:pathology*
D054392:Adipokines; D018836:Inflammation Mediators