[Effect of path-length variations on PLSR calibration model in noninvasive measurement of blood glucose by mid-infrared spectroscopy].
In noninvasive blood glucose measurement, it is difficult to keep the contact area between skin and internal reflectance element uniform while the mid-infrared spectra of human skin are taken, and this would lead to path-length variations. To study the effect of path-length variations on PLSR calibration model, in the present paper, according to the correlation coefficients between path-lengths and glucose concentrations, two PLSR models were achieved respectively and RMSECV were 31.3 and 4.52 mg x dL(-1), RMSEP were 30.3 and 98.7 mg x dL(-1) for the validation set. The results show that the chance correlations between path-lengths and glucose concentrations will lead to calibration models with different accuracy and robustness. This is useful to improving the reliability of noninvasive measurement of blood glucose by mid-infrared spectroscopy.
Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou 510632, China. wdongmin@126.com
Dong-min
DM
Wang
Qi-peng
QP
Lu
Hai-quan
HQ
Ding
Fu-rong
FR
Huang
D001786:Blood Glucose; D002138:Calibration; D006801:Humans; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012867:Skin; D013055:Spectrophotometry, Infrared
D001786:Blood Glucose