Epithelioid hemangioendothelioma of the kidney treated with sunitinib.
BACKGROUND
Metastatic epithelioid hemangioendothelioma of the kidney is a rare malignant vascular tumor with a wide spectrum of behaviors.


METHODS
We present the case of a 53-year-old male patient with tumor metastases which developed after radical nephrectomy. We describe the immunohistochemistry profile of the tumor and the successful long-term results of treatment with sunitinib, a multi-targeted tyrosine kinase inhibitor. Also, we discuss the rationale for using this type of medication based on immunohistochemistry results.


CONCLUSIONS
To the best of our knowledge, this is the first reported case of metastatic renal epithelioid hemangioendothelioma treated successfully with sunitinib.
Urology Clinic, Military Medical Academy, Saint-Petersburg, Russia. yuri.tolkach@gmail.com
Yuri
Y
Tolkach
Sergey
S
Petrov
Evelyne
E
Lerut
Hendrik
H
Van Poppel
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use*; D000077210:Sunitinib; D016896:Treatment Outcome
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib