Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis, but do not predict a flare of synovitis.
OBJECTIVE
To investigate whether children with juvenile idiopathic arthritis (JIA) in clinical remission have subclinical synovial disease on ultrasound, and whether ultrasound abnormalities predict an early flare of synovitis.


METHODS
Thirty-nine consecutive children who had clinically defined inactive disease (ID) for a minimum of 3 months underwent ultrasound assessment of 52 joints. All joints were scanned for synovial hyperplasia, joint effusion, power Doppler (PD) signal and tenosynovitis. Patients were then followed clinically for up to 2 years until a flare of synovitis occurred in one or more joints, or until the 2-year visit if the disease remained in clinical remission.


RESULTS
Synovial hyperplasia, joint effusion, PD signal and tenosynovitis in at least one joint were detected in 76.9%, 66.7%, 33.3% and 15.4% of patients, respectively. During the 2-year follow-up, 24 patients (61.5%) experienced sustained ID, whereas 15 patients (38.5%) had a flare of synovitis in a total of 45 joints after a median of 10.6 months (range 6.3-13.7 months). At study entry, the rate of synovial hyperplasia, joint effusion and tenosynovitis was comparable between patients with persistent ID and patients with synovitis flare, whereas patients with persistent ID had a greater frequency of PD signal than patients with synovitis flare. Only 17 of the 45 flared joints had ultrasound abnormalities at study entry.


CONCLUSIONS
The authors found that ultrasound-detected synovial abnormalities are common in children with JIA in clinical remission. However, the presence of ultrasound pathology did not predict an early flare of synovitis in the affected joints.
Correspondence to Dr Silvia Magni-Manzoni, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino Gesù, Rome, 00165, Italy. s.magnimanzoni@smatteo.pv.it
Silvia
S
Magni-Manzoni
Carlo Alberto
CA
Scirè
Angelo
A
Ravelli
Catherine
C
Klersy
Silvia
S
Rossi
Valentina
V
Muratore
Chiara
C
Visconti
Stefano
S
Lanni
Pietro
P
Merli
Carlomaurizio
C
Montecucco
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D013583:Synovial Membrane / Q000000981:diagnostic imaging* / Q000473:pathology; D013585:Synovitis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D014463:Ultrasonography; D055815:Young Adult