Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines.
A concise synthesis of polycyclic pyrroloindolines from simple malonic diamides via an intramolecular oxidative coupling/condensative cyclization cascade process is reported. The reaction provides an efficient method to construct polycyclic pyrroloindolines in good to excellent yields, which should be useful in the synthesis of natural products and pharmaceutical molecules.
School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Feng
F
Fan
Weiqing
W
Xie
Dawei
D
Ma
D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods; D003500:Cyclization; D003958:Diamide / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
D007211:Indoles; D008314:Malonates; D011083:Polycyclic Compounds; D011758:Pyrroles; D003958:Diamide