Dose-response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin.
In order to determine the effective dose, the effects of orally administered ketoprofen were evaluated in pigs following intravenous challenge with Escherichia coli endotoxin. One hour after the challenge, five groups of pigs were treated with either tap water or ketoprofen (0.5 mg/kg, 1 mg/kg, 2 mg/kg or 4 mg/kg). The body temperature was measured and a total clinical score was calculated after assessing the general behaviour, respiratory rate and locomotion of the pigs. Thromboxane B(2) and ketoprofen concentrations were analysed from blood samples. Ketoprofen treatment significantly reduced the rectal temperature and total clinical scores, and lowered blood thromboxane B(2) concentrations when compared with the control group. Ketoprofen plasma concentrations were lower than previously reported in healthy pigs after similar doses. The appropriate dose of orally administered ketoprofen in pigs in this model is 2 mg/kg, as the higher dose of 4 mg/kg failed to provide an additional benefit.
Department of Equine and Small Animal Medicine, University of Helsinki, P. O. Box 57, 00014 Helsinki, Finland. katja.m.mustonen@helsinki.fi
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K
Mustonen
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Banting
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Raekallio
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M
Heinonen
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Peltoniemi
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Vainio
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000008:administration & dosage*; D005260:Female; D007660:Ketoprofen / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D010146:Pain / Q000188:drug therapy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000188:drug therapy*; D013929:Thromboxane B2 / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004731:Endotoxins; D013929:Thromboxane B2; C044101:endotoxin, Escherichia coli; D007660:Ketoprofen