Study of time reversibility/irreversibility of cardiovascular data: theoretical results and application to laser Doppler flowmetry and heart rate variability signals.
Time irreversibility can be qualitatively defined as the degree of a signal for temporal asymmetry. Recently, a time irreversibility characterization method based on entropies of positive and negative increments has been proposed for experimental signals and applied to heart rate variability (HRV) data (central cardiovascular system (CVS)). The results led to interesting information as a time asymmetry index was found different for young subjects and elderly people or heart disease patients. Nevertheless, similar analyses have not yet been conducted on laser Doppler flowmetry (LDF) signals (peripheral CVS). We first propose to further investigate the above-mentioned characterization method. Then, LDF signals, LDF signals reduced to samples acquired during ECG R peaks (LDF_R(ECG) signals) and HRV recorded simultaneously in healthy subjects are processed. Entropies of positive and negative increments for LDF signals show a nonmonotonic pattern: oscillations--more or less pronounced, depending on subjects--are found with a period matching the one of cardiac activity. However, such oscillations are not found with LDF_R(ECG) nor with HRV. Moreover, the asymmetry index for LDF is markedly different from the ones of LDF_R(ECG) and HRV. The cardiac activity may therefore play a dominant role in the time irreversibility properties of LDF signals.
LUNAM Université, LISA-Laboratoire d'Ingénierie des Systèmes Automatisés, 62 avenue Notre Dame du Lac, 49000 Angers, France.
Anne
A
Humeau-Heurtier
Guillaume
G
Mahé
François
F
Chapeau-Blondeau
David
D
Rousseau
Pierre
P
Abraham
D000328:Adult; D005260:Female; D006339:Heart Rate; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008297:Male; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors