The quest for self-identity: not all cancer stem cells are the same.
A central critique of the cancer stem cell (CSC) hypothesis involves the robustness of CSC markers. Zorniak and colleagues suggest that different progenitor marker profiles can classify CSCs, and improved modeling of cellular hierarchies can be achieved by incorporating inter- and intratumoral diversity.
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. richj@ccf.org
Anita B
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Hjelmeland
Jeremy N
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Rich
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000201:enzymology*; D015870:Gene Expression; D005909:Glioblastoma / Q000201:enzymology*; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571337:CNP protein, human