Lysine methylation and the regulation of p53.
The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular reference to lysine methylation, and discuss implications for future research.
Laboratory of Cancer Biology, Department of Oncology, Medical Sciences Division, University of Oxford, Headington, Oxford OX3 7DQ, U.K.
Simon M
SM
Carr
Shonagh
S
Munro
Nicholas B
NB
La Thangue
D000818:Animals; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D008745:Methylation; D008954:Models, Biological; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D008239:Lysine