N-terminal acetylation and other functions of Nα-acetyltransferases.
Protein N-terminal acetylation by Nα-acetyltransferases (NATs) is an omnipresent protein modification that affects a large number of proteins. The exact biological role of N-terminal acetylation has, however, remained enigmatic for the overall majority of affected proteins, and only for a rather small number of proteins, N-terminal acetylation was linked to various protein features including stability, localization, and interactions. This minireview tries to summarize the recent progress made in understanding the functionality of N-terminal protein acetylation and also focuses on noncanonical functions of the NATs subunits.
Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology-VIB, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.
Jolien
J
Hollebeke
Petra
P
Van Damme
Kris
K
Gevaert
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D000123:Acetyltransferases