Synthesis of aza-fused polycyclic quinolines via double C-H bond activation.
Simple but efficient: Aza-fused polycyclic quinolines were efficiently assembled through rhodium(III)-based direct double C-H activation of N-aryl azoles followed by cyclization with alkynes without heteroatom-assisted chelation. Copper(II) acetate, aside from acting as an oxidant, could also play an important role in the C-H activation process.
Key Laboratory of Drug-Targeting and Drug Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, 17/3 South Renmin Road, Chengdu, 610041, PR China.
Ji-Rong
JR
Huang
Lin
L
Dong
Bo
B
Han
Cheng
C
Peng
Ying-Chun
YC
Chen
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006860:Hydrogen Bonding; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
D001372:Aza Compounds; D011083:Polycyclic Compounds; D011804:Quinolines; D003300:Copper; D012238:Rhodium