[Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases].
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Yaxing
Y
Xu
Saifeng
S
Wang
Xiaojun
X
Zhang
Songdong
S
Meng
D000818:Animals; D003141:Communicable Diseases / Q000628:therapy*; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006360:Heat-Shock Proteins