Class-specific effector functions of therapeutic antibodies.
Physiology usually combines polyclonal antibodies of multiple classes in a single humoral response. Beyond their common ability to bind antigens, these various classes of human immunoglobulins carry specific functions which can each serve specific goals. In many cases, the function of a monoclonal therapeutic antibody may thus be modulated according to the class of its constant domains. Depending on the immunoglobulin class, different functional assays will be used in order to evaluate the functional activity of a monoclonal antibody.
CNRS UMR6101, Contrôle des Réponses Immunes B et Lymphoproliférations, Université de Limoges, Limoges, France.
Virginie
V
Pascal
Brice
B
Laffleur
Michel
M
Cogné
D000818:Animals; D000906:Antibodies / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007136:Immunoglobulins / Q000009:adverse effects / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D051379:Mice
D000906:Antibodies; D000911:Antibodies, Monoclonal; D007136:Immunoglobulins