[Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars].
In addition to major allergens, also minor allergens, i.e. panallergens have been shown to be responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. It can be explained also by cross-allergenicity underlying the T cell response to conserved regions of panallergens. In this article, we focus on known panallergens which presently comprise a few protein families, including non-specific lipid transfer proteins (nsLTP) (PR-14), thaumatin like proteins (TLP) (PR-5), profilins, and polcalcins. Food allergy has an impact on the quality of life of an allergic patient. The way of developing novel plant cultivars with decreased allergenicity and possibility of down-regulating the expression of an allergen by genetic modification are discussed.
Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Ogrodnictwa i Architektury Krajobrazu, Katedra Genetyki Hodowli i Biotechnologii Roślin. kamilabokszczanin@o2.pl
Kamila Ł
KŁ
Bokszczanin
Andrzej A
AA
Przybyła
D000485:Allergens / Q000235:genetics*; D052179:Antigens, Plant / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D001947:Breeding; D002352:Carrier Proteins / Q000378:metabolism; D003429:Cross Reactions / Q000276:immunology; D032621:DNA Shuffling; D015536:Down-Regulation; D005512:Food Hypersensitivity / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000235:genetics* / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D051304:Profilins / Q000378:metabolism
D000485:Allergens; D052179:Antigens, Plant; D002352:Carrier Proteins; D010940:Plant Proteins; D051304:Profilins; C511920:lipid transfer proteins, plant; D007073:Immunoglobulin E; C003427:thaumatin protein, plant