[Effect of the histone deacetylase inhibitor sodium butyrate on the viability and life span in Drosophila melanogaster].
Histone acetylation (one of the most important epigenetic mechanisms controlling gene expression) has been recently shown to be involved in life span (LS) determination. There are some data indicating the geroprotective potential of histone deacetylase (HDAC) inhibitors. In the present study, the effects of HDAC inhibitor, sodium butyrate (SB), on the parameters of viability and LS of Drosophila melanogaster were studied. Since SB is an efficient inducer of epigenetic changes, it can be assumed that its use as a life-extending agent (geroprotector) can be quite promising.
A M
AM
Vaĭserman
A K
AK
Koliada
N M
NM
Koshel'
A V
AV
Simonenko
E G
EG
Pasiukova
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D044127:Epigenesis, Genetic / Q000187:drug effects; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism*; D059165:Hormesis / Q000187:drug effects; D006358:Hot Temperature; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D008297:Male; D012098:Reproduction / Q000187:drug effects / Q000235:genetics; D016019:Survival Analysis
D002087:Butyrates; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases