Naphthalenones from a Perenniporia sp. inhabiting the larva of a phytophagous weevil, Euops chinesis.
The new naphthalenone derivatives perenniporides A-D (1-4) were isolated from solid cultures of a fungus Perenniporia sp. inhabiting the larva of Euops chinesis, a phytophagous weevil with high host specificity to the medicinal plant Fallopia japonica. The structures of 1-4 were elucidated primarily by NMR experiments, and 1 was confirmed by X-ray crystallography. The absolute configuration of 1 and 2 was assigned by electronic circular dichroism (ECD) calculations, whereas that of the C-10 tertiary alcohol in 3 was deduced via the CD data of the in situ formed [Rh(2)(OCOCF(3))(4)] complex and supported by the ECD data. Compound 1 showed antifungal activity against five plant pathogens.
State Key Laboratory of Mycology,  Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.
Yu
Y
Feng
Lin
L
Wang
Shubin
S
Niu
Li
L
Li
Yikang
Y
Si
Xingzhong
X
Liu
Yongsheng
Y
Che
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005658:Fungi; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000382:microbiology; D008968:Molecular Conformation; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011124:Polyporaceae / Q000737:chemistry*; D048889:Weevils
D000935:Antifungal Agents; D006575:Heterocyclic Compounds, 3-Ring; D009281:Naphthalenes