Baculovirus as a vaccine vector.
Baculovirus is extensively utilized as an excellent tool for production of recombinant protein in insect cells. Baculovirus infects insects in nature and is non-pathogenic to humans. In addition to insect cells, baculovirus is capable of transducing a broad range of animal cells. Due to its biosafety, large cloning capacity, low cytotoxicity, and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has been utilized as RNA interference mediators, gene delivery vectors, and vaccine vectors for a wide variety of applications. This article focuses on the utilization of baculoviruses as vaccine vectors to prepare antigen or subunit vaccines.
Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
Hsin-Yu
HY
Lu
Yi-Hsuan
YH
Chen
Hung-Jen
HJ
Liu
D000818:Animals; D016367:Baculoviridae / Q000235:genetics*; D061505:Cell Surface Display Techniques; D002478:Cells, Cultured; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D007313:Insecta / Q000166:cytology / Q000821:virology; D034622:RNA Interference; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics; D014161:Transduction, Genetic; D022223:Vaccines, Subunit / Q000096:biosynthesis / Q000235:genetics*
D011994:Recombinant Proteins; D022223:Vaccines, Subunit