Changes of serum adiponectin and soluble intercellular adhesion molecule-1 concentrations after smoking cessation.
BACKGROUND
This study aims to investigate the effect of increased serum adiponectin concentration during smoking cessation on soluble intercellular adhesion molecule-1 (sICAM-1) concentration.


METHODS
One hundred and sixty-six eligible smokers were assessed at baseline and were followed up at the 1st, 5th, and 9th weeks after smoking cessation. Demographic data, body weight and blood pressure of these participants were obtained; serum glucose biochemical data, sICAM-1 and adiponectin concentrations were measured. Repeated measures analysis paired t-tests and generalized estimating equations for balanced repeated measures were used for statistical analyses.


RESULTS
Forty-one individuals completed the 2-month smoking cessation program. The mean cigarette consumption dramatically decreased (p<0.0001) and the cotinine concentration also decreased significantly (p<0.0001) among the quitters. Serum adiponectin concentration significantly increased (p=0.0186) and sICAM-1 significantly decreased (p<0.0001) in quitters after smoking cessation. The elevation of serum adiponectin concentration significantly correlated with lowering of sICAM-1 (p=0.0001) concentration. Body weight changes at the end of 2-month smoking cessation was inversely correlated with adiponectin increment from baseline (p=0.0003).


CONCLUSIONS
An increase in serum adiponectin concentration is an independent factor correlated with lowering of sICAM-1 concentration during smoking cessation.
Department of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jaw-Shiun
JS
Tsai
Fei-Ran
FR
Guo
Su-Chiu
SC
Chen
Bee-Horng
BH
Lue
Long-Teng
LT
Lee
Kuo-Chin
KC
Huang
Chin-Ying
CY
Chen
Shou-Hung
SH
Hung
Lee-Ming
LM
Chuang
Ching-Yu
CY
Chen
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D016540:Smoking Cessation; D012995:Solubility
D052242:Adiponectin; D018799:Intercellular Adhesion Molecule-1