Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera.
β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.
Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan.
Reiko
R
Maeda
Tomoaki
T
Ida
Hideshi
H
Ihara
Tatsuji
T
Sakamoto
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D046068:Caulerpa / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002843:Chromatin / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011489:Protein Denaturation; D012972:Sodium Hydroxide / Q000737:chemistry; D013464:Sulfuric Acids / Q000737:chemistry; D014990:Xylans / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D002843:Chromatin; D009844:Oligosaccharides; D010936:Plant Extracts; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D013464:Sulfuric Acids; D014990:Xylans; D012972:Sodium Hydroxide; C065917:1,3-xylan; C033158:sulfuric acid