New insights into the role of NK cells in cancer immunotherapy.
Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity.
Cancer Immunology and Immunotherapy Center; Saint Savas Cancer Hospital; Athens, Greece.
Maria
M
Salagianni
Constantin N
CN
Baxevanis
Michael
M
Papamichail
Sonia A
SA
Perez