Child abuse in medical setting presenting as gross hematuria: diagnosis by DNA short tandem repeats.
Two sisters, aged 15 and 13 years, had previous epithelioid angiomyolipoma of the kidney and suspected thin basement membrane disease, respectively. They presented with 2 years of gross hematuria and new-onset heavy proteinuria. Extensive investigations failed to find an overt cause of their urinary manifestations. The diagnosis of child abuse in a medical setting was confirmed by DNA short tandem repeats analysis, which are the first documented cases in which factitious hematuria was thus diagnosed. Complex forms of child abuse in a medical setting may require forensic tests such as DNA short tandem repeats analysis for diagnosis.
Division of Pediatric Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsin-Lin
HL
Tsai
Ling-Yu
LY
Yang
Tai-Wai
TW
Chin
Po-Hon
PH
Chen
Hsiu-Ju
HJ
Yen
Chin-Su
CS
Liu
Hsin-Hui
HH
Wang
Jei-Wen
JW
Chang
D000293:Adolescent; D005260:Female; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D018895:Microsatellite Repeats; D016735:Munchausen Syndrome by Proxy / Q000175:diagnosis*; D017422:Sequence Analysis, DNA