Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis.
Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), a native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases. The aim of this study was to evaluate the cytotoxic and leishmanicidal effects of GFC using in vitro models. The experimental data demonstrated that the polyisoprenylated benzophenone GFC possesses cytotoxic and leishmanicidal activities.
Departamento de Química, Instituto Federal do Piauí, PI 64000-040, Teresina, Brazil.
Joaquim S
JS
Costa Júnior
Antonia Amanda Cardoso
AA
de Almeida
Alexandre
A
de Barros Falcão Ferraz
Raíssa Rebés
RR
Rossatto
Teresinha G
TG
Silva
Paulo B N
PB
Silva
Gardenia C G
GC
Militão
Antonia Maria
AM
das Graças Lopes Citó
Lorena Citó Lopes Resende
LC
Santana
Fernando Aécio
FA
de Amorim Carvalho
Rivelilson M
RM
Freitas
D001577:Benzophenones / Q000737:chemistry*; D045744:Cell Line, Tumor; D028084:Clusiaceae / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D014315:Triterpenes; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*
D001577:Benzophenones; D014315:Triterpenes; D014344:Trypanocidal Agents; C573355:garcinielliptone FC; C047723:benzophenone