Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice.
Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.
Laboratory of Host Defense Modulation, College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, Republic of Korea.
Tae Joon
TJ
Won
Bongjoon
B
Kim
Yunjung
Y
Lee
Joon Seok
JS
Bang
Eun Seul
ES
Oh
Jong-Sun
JS
Yoo
Kyeong Eun
KE
Hyung
Joowon
J
Yoon
Sehee
S
Hwang
Eon Sub
ES
Park
So-Young
SY
Park
Kwang Woo
KW
Hwang
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D017449:Dermatitis, Allergic Contact / Q000382:microbiology* / Q000473:pathology / Q000628:therapy*; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D048191:Lactiplantibacillus plantarum; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008407:Mast Cells / Q000473:pathology; D051379:Mice; D039981:Pyroglyphidae / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
D016207:Cytokines; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma