Busseihydroquinones A-D from the roots of Pentas bussei.
Four new naphthohydroquinones, named busseihydroquinones A-D (1-4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH(2)Cl(2)/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.
Department of Chemistry,  University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
Milkyas
M
Endale
Annabel
A
Ekberg
Hoseah M
HM
Akala
John Patrick
JP
Alao
Per
P
Sunnerhagen
Abiy
A
Yenesew
Máté
M
Erdélyi
D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007630:Kenya; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*
D000962:Antimalarials; D006873:Hydroquinones; D002738:Chloroquine