Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles.
BACKGROUND
The acquirement of resistance by microorganisms to the antimicrobial arsenal is a threat to public health. A recent WHO report estimated that 1.3 million HIV-negative people and 0.38 million HIV-positive people died from TB in 2009. Various forms of cancer account for a high percentage of deaths in both women (breast cancer) and men (prostate cancer).


CONCLUSIONS
In vitro activity assessment of newly constructed s-triazines against a panel of microorganisms including bacteria, fungi and Mycobacteria demonstrated that the compounds are of immense attraction for impending drug discovery. They were further examined for in vitro activity against breast cancer and prostate cancer cell lines, as well as HIV-1 (III(B)) and HIV-2 (ROD) viral strains. Proposed structural confirmation studies by IR, (1)H NMR, (13)C NMR, (19)F NMR spectroscopy and elemental analysis were in accordance.


CONCLUSIONS
Activity profiles of the products may contribute considerably to future drug-discovery studies.
Department of Applied Chemistry, S.V. National Institute of Technology, Surat 395 007, India. rahul.svnit11@gmail.com
Rahul V
RV
Patel
Premlata
P
Kumari
Dhanji P
DP
Rajani
Christophe
C
Pannecouque
Erik
E
De Clercq
Kishor H
KH
Chikhalia
D019380:Anti-HIV Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D005260:Female; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000737:chemistry*
D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D006571:Heterocyclic Compounds; D014227:Triazines