Clinical factors influencing corrected count increment.
Refractoriness to platelet transfusions is a common clinical problem. The present study was conducted to look into patient characteristics affecting the corrected count increment in a tertiary care referral hospital. A total of 161 aphaeresis platelet units were transfused to 40 patients with varied clinical diagnoses. The mean platelet increment was 17,789/mm(3). Median corrected count increment was 7344 and percentage platelet recovery was 22.82%. Logistic regression analysis revealed significant influence of splenomegaly and anti-platelet drugs on refractoriness. Fever, bleeding, sepsis, disseminated intravascular coagulation and cyclosporine use, though more common in the patients with refractoriness they were not statistically significant.
Department of Transfusion Medicine in Kasturba, Medical College, Manipal University, Manipal, India.
Shamee
S
Shastry
Rajendra
R
Chaudhary
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000295:instrumentation / Q000379:methods*; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods*; D010983:Plateletpheresis / Q000379:methods*; D011446:Prospective Studies; D055815:Young Adult