Intermittent administration of recombinant human soluble thrombomodulin successfully controlled chronic disseminated intravascular coagulation in a patient with dissecting aortic aneurysm on an outpatient basis.
Chronic disseminated intravascular coagulation (DIC) is a rare but life-threatening complication of dissecting aortic aneurysm. Although anticoagulant therapy may often proves effective for controlling DIC itself, patients would have to be hospitalized for a long period due to continuous infusion therapy. Subcutaneous injection of a highly concentrated preparation of heparin calcium may offer one alternative treatment for DIC; however, daily subcutaneous use of heparin for the treatment of DIC has impaired quality of life (QOL). The other alternative therapy is intravenous administration of recombinant human soluble thrombomodulin (rTM), which includes the active extracellular domain of thrombomodulin. Reportedly, rTM effectively resolves DIC by only 6 consecutive days of administration; however, how frequently rTM should be administered after the resolution of chronic DIC to have good control of it has been unclear. We report herein a case of chronic DIC complicated with dissecting aortic aneurysm, whose resolution of chronic DIC achieved by 6 consecutive days of rTM has been maintained by once a week administration of rTM on an outpatient basis.
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Satoshi
S
Iyama
Tsutomu
T
Sato
Kazuyuki
K
Murase
Yusuke
Y
Kamihara
Kaoru
K
Ono
Shohei
S
Kikuchi
Kohichi
K
Takada
Koji
K
Miyanishi
Yasushi
Y
Sato
Rishu
R
Takimoto
Masayoshi
M
Kobune
Junji
J
Kato
D061605:Administration, Intravenous; D000553:Ambulatory Care; D000784:Aortic Dissection / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001014:Aortic Aneurysm / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011994:Recombinant Proteins / Q000008:administration & dosage*; D018180:Thrombomodulin / Q000008:administration & dosage*
D011994:Recombinant Proteins; D018180:Thrombomodulin