FOXO3: A master switch for regulating tolerance and immunity in dendritic cells.
Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.
Tumor Immunity and Tolerance Section; Laboratory of Molecular Immunoregulation; Cancer and Inflammation Program; NCI-Frederick; Frederick, MD USA.
Stephanie K
SK
Watkins
Arthur A
AA
Hurwitz