[Association of point mutations in human nuclear and mitochondrial genome with coronary artery disease].
In pathogenesis of coronary artery disease (CAD), participate as genes of nuclear genome, regulating a metabolism of lipids and carbohydrates, and genes of mitochondrial DNA (mtDNA) which are the basic regulators of ATP synthesis process and breath of cages. Thanks to expansion of sample of patients and the description of hundreds family trees, data on mutual relation between genotype and a phenotype, structure and frequency of occurrence of mutations at CAD collect the accelerated rates. In the present review, mutations of mitochondrial and nuclear genomes are person, associated with clinical displays of an atherosclerosis (CAD) and accompanying pathologies of the person are presented. Mutations are classified on an accessory to mitochondrial or nuclear genome, the pathologies associated with them and position in genome are specified.
K Iu
KIu
Mitrofanov
M A
MA
Sazonova
D050260:Carbohydrate Metabolism / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D015894:Genome, Human; D054629:Genome, Mitochondrial; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D017354:Point Mutation