Dual temperature and thiol-responsive POEOMA-multisegmented polydisulfides: synthesis and thermoresponsive properties.
New thermoresponsive polydisulfides of POEOMA multiblocks linked with disulfide bonds having redox-responsive properties are reported. These POEOMA-multisegmented polydisulfides were synthesized by a new method employing a combined RAFT/aminolysis and reversible thiol-disulfide redox reaction that centers on the synthesis of new disulfide-labeled difunctional RAFT agent. RAFT polymerization proceeded in living fashion, yielding well-defined POEOMA copolymers with middle disulfides and terminal RAFT species. They were then used as precursors for thiol-disulfide polyexchange induced by aminolysis and reductive reaction followed by oxidation: these polydisulfides with different molecular weights and end groups exhibited tunable thermoresponsive properties and thiol-responsive degradation.
Department of Chemistry and Biochemistry and Center for Nanoscience Research, Concordia University, Montreal, Quebec, Canada.
Qian
Q
Zhang
Seung Man
SM
Noh
Joon Hyun
JH
Nam
Hyun Wook
HW
Jung
Jong Myung
JM
Park
Jung Kwon
JK
Oh
D004220:Disulfides / Q000737:chemistry*; D010084:Oxidation-Reduction; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013696:Temperature
D004220:Disulfides; D011108:Polymers; D013438:Sulfhydryl Compounds