Cucurbit[7]uril pseudorotaxane-based photoresponsive supramolecular nanovalve.
Light relief! Mesoporous silica materials equipped with photoresponsive cucurbit[7]uril-pseudorotaxane nanovalves operate in biological media to trap cargo molecules within nanopores, but undergo controlled release when irradiated with light of a suitable wavelength (see figure). Significantly, a "ladder"-release pattern is obtained to balance maximal therapeutic efficacy and minimal dose frequency in the development of "pulsed" drug therapy.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012, PR China.
Yu-Long
YL
Sun
Bing-Jie
BJ
Yang
Sean Xiao-An
SX
Zhang
Ying-Wei
YW
Yang
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D058608:Nanopores; D010782:Photolysis; D043862:Rotaxanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D007093:Imidazoles; D043862:Rotaxanes; D012822:Silicon Dioxide; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils