Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: expedient access to substituted 13C2-labeled phenethylamines.
A novel and general approach for (13)C(2)- and (2)H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.
Department of Chemistry, Center for Insoluble Protein Structures (InSPIN), and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Dennis U
DU
Nielsen
Karoline
K
Neumann
Rolf H
RH
Taaning
Anders T
AT
Lindhardt
Amalie
A
Modvig
Troels
T
Skrydstrup
D002247:Carbon Isotopes; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000737:chemistry
D002247:Carbon Isotopes; D009942:Organometallic Compounds; D010627:Phenethylamines; D010165:Palladium; D002248:Carbon Monoxide