On the origin of sustained negative BOLD response.
Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
MARBILab, Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, Roma, Italy.
Marta
M
Moraschi
Mauro
M
DiNuzzo
Federico
F
Giove
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000502:physiology; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D011323:Primates
D010100:Oxygen