Detection of perioperative myocardial infarction with ischemia-modified albumin.
We assessed the perioperative pattern of serum ischemia-modified albumin and its role as a myocardial ischemia indicator for early detection of perioperative myocardial infarction in patients undergoing off-pump coronary artery bypass grafting. Venous blood samples were collected from 63 consecutive patients before the operation, immediately after the operation, and at 3, 6, 12, and 24 h postoperatively. Serum ischemia-modified albumin levels were analyzed using an albumin cobalt binding test. The patients were divided into 2 groups retrospectively, according to the occurrence of perioperative myocardial infarction. The serum ischemia-modified albumin levels were compared between groups. The levels peaked immediately after the operation, followed by a gradual regression, but remained elevated during the first 24 h in all patients. The occurrence of perioperative myocardial infarction was identified in 10 patients who had significantly higher ischemia-modified albumin levels at 3 h postoperatively and slower regression rates. Perioperative serum ischemia-modified albumin levels might be helpful in predicting perioperative myocardial infarction.
Department of Cardiac Surgery, the First Hospital, Peking University, Beijing 100034, PR China.
Shi-Yong
SY
Dong
Xue-Jing
XJ
Wang
Feng
F
Xiao
Jin
J
Wang
Yi-Fan
YF
Li
Yan
Y
Li
D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002681:China; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D059035:Perioperative Period; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D013997:Time Factors; D015854:Up-Regulation
D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human