The M5nr: a novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools.
BACKGROUND
Computing of sequence similarity results is becoming a limiting factor in metagenome analysis. Sequence similarity search results encoded in an open, exchangeable format have the potential to limit the needs for computational reanalysis of these data sets. A prerequisite for sharing of similarity results is a common reference.


METHODS
We introduce a mechanism for automatically maintaining a comprehensive, non-redundant protein database and for creating a quarterly release of this resource. In addition, we present tools for translating similarity searches into many annotation namespaces, e.g. KEGG or NCBI's GenBank.


CONCLUSIONS
The data and tools we present allow the creation of multiple result sets using a single computation, permitting computational results to be shared between groups for large sequence data sets.
Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
Andreas
A
Wilke
Travis
T
Harrison
Jared
J
Wilkening
Dawn
D
Field
Elizabeth M
EM
Glass
Nikos
N
Kyrpides
Konstantinos
K
Mavrommatis
Folker
F
Meyer
D019295:Computational Biology; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D056186:Metagenomics; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D012984:Software
D011506:Proteins