Characterizing the major sonographic textural difference between metastatic and common benign lymph nodes using support vector machine with histopathologic correlation.
Sonographic texture analysis can reflect histopathological components and their arrangement in metastatic and common benign lymph nodes. It is helpful in differentiation between metastatic and benign lymph node lesions for target selection during biopsy of multiple lymph nodes and the strategy of the management. Two ultrasound systems, 107 sonographic regions of interest (ROIs) of metastases and 174 sonographic ROIs of common benign lymph nodes, were recruited in the study. Thirteen texture features derived from co-occurrence matrix were used in characterization of above ROI ultrasound images. Support vector machine (SVM) was used as a classifier and a feature selector. The experimental results show that the entropy gains the best cross-validation accuracy of 94.66% and 87.73% in both ultrasound systems 1 and 2 for the classification of metastatic and benign lymph nodes disease. The accuracy can be further increased to 97.86% and 100% by the combination of the sum average in the study. There are significantly higher entropy and sum average values of the metastatic lymph nodes than of the benign lymph nodes, which are due to the heterogeneous compositions and arrangement of larger cancer cells, lymphocytes, and stroma in metastatic lymph nodes that contrast with simple inflammatory cells infiltration in common benign lymph nodes.
Department of Medical Imaging, Buddhist Dalin Tzu Chi General, Hospital, Chia-Yi, Taiwan, ROC.
Shao-Jer
SJ
Chen
Chun-Hung
CH
Lin
Chuan-Yu
CY
Chang
Ku-Yaw
KY
Chang
Hsu-Chueh
HC
Ho
Shih-Hsuan
SH
Hsiao
Chih-Wen
CW
Lin
Jeh-En
JE
Tzeng
Yen-Ting
YT
Chen
Hong-Ming
HM
Tsai
D000293:Adolescent; D000328:Adult; D000368:Aged; D001365:Axilla / Q000473:pathology; D001707:Biopsy, Needle; D016022:Case-Control Studies; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008199:Lymphadenitis / Q000000981:diagnostic imaging / Q000473:pathology; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results; D060388:Support Vector Machine; D018608:Ultrasonography, Doppler / Q000379:methods*; D055815:Young Adult