Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant.
Scrub typhus is a rickettsial disease, caused by Orientia tsutsugamushi, which is transmitted via the bite of a chigger. This disease is one of the most important infectious diseases in the Asia-Pacific area; however, a severe infant case has not yet been reported. Here, we present the case of an 8-month-old boy with scrub typhus accompanied by hemophagocytic lymphohistiocytosis (HLH). His rapid course was complicated by acute respiratory distress syndrome (ARDS), status epilepticus and disseminated intravascular coagulation (DIC). He recovered after clarithromycin therapy and intensive supportive care. Although being extremely rare, scrub typhus can be life-threatening in an infant; therefore, physicians in endemic countries should be aware of the necessity for early recognition and prompt treatment of suspected cases.
Department of Pediatrics, College of Medicine, Korea University, 152-703 Seoul, Republic of Korea.
Hyo Jin
HJ
Kwon
In Hyuk
IH
Yoo
Jae-Wook
JW
Lee
Nak Gyun
NG
Chung
Bin
B
Cho
Hack-Ki
HK
Kim
Jin Han
JH
Kang
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D006384:Hemagglutination; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000175:diagnosis; D008297:Male; D012285:Orientia tsutsugamushi / Q000276:immunology; D012612:Scrub Typhus / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D045169:Severe Acute Respiratory Syndrome / Q000150:complications*; D013226:Status Epilepticus / Q000150:complications; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D017291:Clarithromycin