Non-apoptotic routes to defeat cancer.
The mechanism of tumor cell death after treatment with DNA alkylating agents in vivo previously remained largely unknown. We demonstrate that tumor regression after chemotherapy occurs via sporadic necrosis and relies on activation of innate immunity in a manner dependent on high mobility group box 1 protein (HMGB1).
Department of Molecular Genetics & Microbiology; Stony Brook University; Stony Brook, NY USA.
Jennifer L
JL
Guerriero
Dara
D
Ditsworth
Wei-Xing
WX
Zong