Cervical human papillomavirus infection and shedding of human immunodeficiency virus in cervicovaginal fluids:  a cross-sectional study.
We evaluated the association between human papillomavirus cervical infection and HIV shedding in cervicovaginal lavage fluid (CVL), studying 89 HIV-infected women recruited at the Department of Infectious Diseases of Brescia (Italy). HIV shedding in CVL was found in a similar proportion of women with (30%; 21/70) and without (31.6%; 6/19) cervical human papillomavirus infection. A statistically significant correlation was found between HIV viral load in serum and CVL among the 27 women with detectable HIV in CVL (r = 0.4; P = 0.04). However, women on highly active antiretroviral therapy were more likely to have detectable HIV-RNA in CVL despite negative viremia (80% vs. 8%; P < 0.005).
Institute of Infectious and Tropical Diseases, Spedali Civili Hospital and University of Brescia, Brescia, Italy.
Chiara
C
Fornabaio
Anna C C
AC
Carvalho
Flavia
F
Lillo
José R
JR
Fiore
Viviana
V
Bergamaschi
Sara
S
Bigoni
Petra R
PR
Puzzi
Graziella
G
Cristini
Mario
M
Comelli
Maria R
MR
Parisi
Alberto
A
Matteelli
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D001769:Blood / Q000821:virology; D001826:Body Fluids / Q000821:virology*; D002584:Cervix Uteri / Q000821:virology; D003430:Cross-Sectional Studies; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D007558:Italy; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*; D014621:Vagina / Q000821:virology; D019562:Viral Load; D017201:Virus Shedding; D055815:Young Adult
D044966:Anti-Retroviral Agents