Total synthesis of (-)-FR901483.
A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
Ai-Jun
AJ
Ma
Yong-Qiang
YQ
Tu
Jin-Bao
JB
Peng
Qing-Yun
QY
Dou
Si-Hua
SH
Hou
Fu-Min
FM
Zhang
Shao-Hua
SH
Wang
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; C098358:FR 901483; D007166:Immunosuppressive Agents; D009943:Organophosphorus Compounds