A functional polymorphism on chromosome 15q25 associated with survival of early stage non-small-cell lung cancer.
BACKGROUND
The 15q25 region has been associated with lung-cancer risk and might also be associated with the prognosis of lung cancer. This study was conducted to determine the impact of a functional polymorphism in the CHRNA3 gene on chromosome 15q25 in the survival of patients with early-stage non-small-cell lung cancer (NSCLC).


METHODS
Five hundred and eighty-three consecutive patients with surgically resected NSCLC were enrolled. The rs6495309C > T polymorphism in the promoter of the CHRNA3 gene was investigated. The association between genotype and overall survival (OS) and disease-free survival (DFS) was analyzed.


RESULTS
Patients with the rs6495309 CT or TT genotype had a significantly better OS and DFS than the rs6495309 CC genotype (adjusted hazard ratio for OS = 0.56, 95% confidence interval = 0.41-0.75, p = 0.0001; and adjusted hazard ratio for DFS = 0.61, 95% confidence interval = 0.48-0.79, p = 0.0001). An association between the rs6495309C > T polymorphism and survival outcome was demonstrated in smokers and never-smokers, and in squamous-cell carcinomas and adenocarcinomas.


CONCLUSIONS
The CHRNA3 rs6495309C > T polymorphism may affect survival in patients with early-stage NSCLC. Analysis of the rs6495309C > T polymorphism can help identify patients at high risk of a poor disease outcome.
Department of Pharmacy, Yanbian, P. R. China.
Guang
G
Jin
Eun Young
EY
Bae
Enyue
E
Yang
Eung Bae
EB
Lee
Won-Kee
WK
Lee
Jin Eun
JE
Choi
Hyo-Sung
HS
Jeon
Seung Soo
SS
Yoo
Shin Yup
SY
Lee
Jaehee
J
Lee
Sung Ick
SI
Cha
Chang Ho
CH
Kim
Sukki
S
Cho
Sanghoon
S
Jheon
Jae Yong
JY
Park
D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011978:Receptors, Nicotinic / Q000235:genetics*; D015996:Survival Rate
D004247:DNA; D011978:Receptors, Nicotinic