The feto-placental endothelium in pregnancy pathologies.
This review aims to provide a comprehensive summary of the aspects of endothelial and vascular dysfunction in the feto-placental vasculature occurring in pregnancy pathologies. This endothelium is continuous with the fetal circulation. Its function and potential dysfunction in pathologies will have a profound impact on fetal development. Gestational diabetes mellitus represents one of these pathologies, in which its associated metabolic derangements will alter feto-placental endothelial functions. These, in turn, may result in functional changes of the placenta, which may entail impaired fetal development. By contrast, changes in the feto-placental vasculature observed in cases of fetal growth restriction and preeclampsia may be causative (fetal growth restriction) or secondary (preeclampsia) for the pathology.
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria. christian.wadsack@medunigraz.at
Christian
C
Wadsack
Gernot
G
Desoye
Ursula
U
Hiden
D016640:Diabetes, Gestational / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology
D040281:Vascular Endothelial Growth Factor Receptor-1