[Oral combined hormonal contraception containing nomegestrol acetate and 17beta-oestradiol--the statement of Polish Gynecological Society Experts Group].
Nomegestrol acetate (NOMAC) combined with E2 (Zoely) is a monophasic oral contraceptive (OC) which safety and efficacy was confirmed in a number of level I evidence clinical trials. Zoely is highly effective OC, especially in overweight and obese patients, with good cycle control, safe and well tolerated. NOMAC/E2 combination causes no or minimal weight gain and is characterized by minimal influence on bone mineral density or blood pressure and presence of acne. Moreover lipids profile, carbohydrates metabolism, haemostasis and endocrine glands functioning were not affected. High tolerance and acceptance of NOMAC/E2 combination by women, low adverse event profile, fast recovery of ovarian activity and ovulation is a reasonable treatment tool in everyday practice.
Romuald
R
Debski
Jan
J
Kotarski
Tomasz
T
Paszkowski
Leszek
L
Pawelczyk
Ryszard
R
Poreba
Violetta
V
Skrzypulec-Plinta
Jacek
J
Tomaszewski
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage*; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006176:Gynecology / Q000592:standards; D006801:Humans; D007318:Inservice Training / Q000592:standards; D008535:Megestrol / Q000008:administration & dosage*; D009313:National Health Programs / Q000592:standards; D009649:Norpregnadienes / Q000008:administration & dosage*; D009774:Obstetrics / Q000592:standards; D010060:Ovulation / Q000187:drug effects; D011044:Poland; D017410:Practice Guidelines as Topic; D055815:Young Adult
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D009649:Norpregnadienes; D004958:Estradiol; C038501:nomegestrol acetate; D008535:Megestrol