Synthesis and characterization of modified starch hydrogels for photodynamic treatment of cancer.
The objective of the present study was to develop carboxymethyl starch (CMS) and dextran sulfate (DS) hydrogels that are able to efficiently encapsulate 5-,10-,15-,20-tetrakis(meso-hydroxyphenyl)porphyrin (mTHPP), a porphyrin-based PS agent. The study showed that the lifetime of the triplet state for porphyrin PS is significantly increase when encapsulate into hydrogel. In addition to the possible enhancement of ¹O₂ generation, other advantages to incorporating porphyrin-based PS agents into hydrogel include the ability to solubilize these generally hydrophobic agents, the small and uniform size of hydrogels, and potential for passive targeting of solid tumors via the enhanced permeation and retention effect decreasing systemic photosensitization. This novel type of carboxymethyl starch (CMS) hydrogel using dextran sulfate (DS) as a polyanionic polymer was developed to achieve complex coacervation for the incorporation and controlled release of an anti-angiogenesis hexapeptide, this was the first report describing the use of DS to formulate CMS based hydrogels.
Nanostructured Materials Synthesis Lab., International Research Institute of Arian Chemie Gostar, Tabriz, Iran. saboktakin123@yahoo.com
Mohammad Reza
MR
Saboktakin
Roya M
RM
Tabatabaie
Parvaneh
P
Ostovarazar
Abel
A
Maharramov
Mohammad Ali
MA
Ramazanov
D000681:Amylases / Q000378:metabolism; D060326:Chemistry Techniques, Synthetic; D016264:Dextran Sulfate / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry; D014783:Viscosity
D004337:Drug Carriers; D020100:Hydrogels; D017319:Photosensitizing Agents; D011166:Porphyrins; C437342:tetra(3-hydroxyphenyl)porphine; D013213:Starch; D016264:Dextran Sulfate; C034848:carboxymethyl starch; D000681:Amylases