[Anti-atherosclerotic effects of peptidic geroprotector].
The study of peptide geroprotector's biological activity was conducted on basis of calf aorta extract Slavinorm in experimental models of hiperlypidemia and acute myocardial infarction. The study results show that Slavinorm possesses the evident antiatherogenic effect. It appears in blood lipid spectrum parameters optimization, including atherogenic coefficient normalization at the expense of high density lipids level increase and other cholesterol fractions decrease. Slavinorm manifested antiischemic effects in the model of acute myocardial infarction, which was expressed in significant decrease of necrotic zone after 4-hours coronary artery occlusion in comparison with parameters in control animals and in low frequency of postobstructive arythmia.
A P
AP
Ryzhak
B I
BI
Kuznik
V N
VN
Putkovskaia
G A
GA
Ryzhak
D000375:Aging / Q000097:blood / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001011:Aorta / Q000737:chemistry; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D002417:Cattle; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D016896:Treatment Outcome
D008055:Lipids; D010455:Peptides