Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
Fibroblast Growth Factors play critical roles during development, tissue homeostasis and repair by controlling cell proliferation, survival, migration and differentiation. Of the 22 mammalian FGFs, FGF22, a member of the FGF7/10/22 subfamily, has been shown to have a clear role in synaptogenesis, but its roles in other tissues have not been studied. We have investigated the in vivo functions of FGF22 in mice. Fgf22 null animals were viable, fertile and did not display any obvious abnormalities. Despite the known expression profile of FGF22 in the skin, no differences in either skin or pelage were observed, demonstrating that FGF22 is dispensable during embryogenesis and in unchallenged adult skin. Mice lacking FGF22 were able to heal acute wounds just as efficiently as wild type mice. However, classical two-step skin carcinogenesis challenge revealed that FGF22 null mice developed fewer papillomas than wild type controls, suggesting a potential pro-oncogenic role for FGF22 in the skin.
Centre for Tumour Biology, Barts Cancer Institute-Cancer Research UK Centre of Excellence, Queen Mary University of London, London, United Kingdom.
Monika
M
Jarosz
Luisa
L
Robbez-Masson
Athina-Myrto
AM
Chioni
Barbara
B
Cross
Ian
I
Rosewell
Richard
R
Grose
D000818:Animals; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006579:Heterozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D010212:Papilloma / Q000378:metabolism; D012867:Skin / Q000473:pathology; D014945:Wound Healing
C476387:Fgf22 protein, mouse; D005346:Fibroblast Growth Factors