Transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line approach in uveal melanoma liver metastases: tumor response and predictive value of diffusion-weighted MR imaging in five patients.
Five patients with uveal melanoma metastatic to the liver (two to five lesions per patient) were prospectively enrolled and treated with transarterial chemoembolization with drug-eluting beads preloaded with irinotecan as a first-line therapy. An overall response rate of 80% was obtained per Response Evaluation Criteria In Solid Tumors. All patients were alive after mean follow-up durations of 10.6 months and 16.3 months, respectively, after the first treatment and the diagnosis of liver metastasis. The apparent diffusion coefficient values obtained by diffusion-weighted magnetic resonance imaging were significantly lower in lesions that showed a response. These findings are very promising and can constitute the background for further studies involving larger cohorts of patients.
Department of Radiology, Scientific Institute H.S. Raffaele, Via Olgettina 60, 20132 Milan, Italy. venturini.massimo@hsr.it
Massimo
M
Venturini
Lorenzo
L
Pilla
Giulia
G
Agostini
Stefano
S
Cappio
Claudio
C
Losio
Marcello
M
Orsi
Francesca
F
Ratti
Luca
L
Aldrighetti
Francesco
F
De Cobelli
Alessandro
A
Del Maschio
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016461:Chemoembolization, Therapeutic / Q000379:methods; D017024:Chemotherapy, Adjuvant / Q000379:methods; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D008863:Microspheres; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000473:pathology / Q000628:therapy*
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D000077146:Irinotecan; D002166:Camptothecin