Aciclovir desensitisation and rechallenge.
A 29-year-old patient with HIV developed a facial angioedema hypersensitivity reaction to aciclovir when treated for acute retinal necrosis secondary to a herpes virus infection. She developed a similar reaction to famciclovir. Successful rapid desensitisation with oral aciclovir was performed and she became tolerant to aciclovir. She successfully completed 28 months of continuous treatment with no further reactions. However, 28 months later she experienced blurred vision and resumed taking oral aciclovir without a preceding desensitisation regimen. No allergic reaction occurred.
Department of Infectious Diseases, Nottingham University Hospitals City Campus, Nottingham, UK.
Susan E
SE
Snape
Roger G
RG
Finch
Pradhib
P
Venkatesan
D000212:Acyclovir / Q000009:adverse effects*; D000328:Adult; D000799:Angioedema / Q000276:immunology*; D000998:Antiviral Agents / Q000009:adverse effects*; D003888:Desensitization, Immunologic; D003875:Drug Eruptions / Q000276:immunology*; D005148:Facial Dermatoses / Q000276:immunology*; D005260:Female; D006801:Humans
D000998:Antiviral Agents; D000212:Acyclovir