[Analysis of the prevalence of HBV markers relevant to the risk of reactivation of infection in patients with hematologic diseases].
The study assessed the incidence of HBV markers (HBsAg, anti-HBc, anti-HBs) important for determination of the risk of reactivation of infection, with particular interest of occult infection (presence of HBV DNA in the absence of HBsAg) in patients treated at the Institute of Hematology and Transfusion Medicine. Anti-HBc frequency was correlated with the age and sex of patients. HBsAg was detected in 16/468 examined patients, 98/468 (21%) were anti-HBc positive. HBV DNA was detected in 41/98 anti-HBc positives; in 13 simultaneously with HBsAg. 28 patients had occult HBV infection (HBV DNA+/HBsAg). Antibody to HBsAg was detected in 163/430 (38%) patients, 81 out of them on protective level (> 100 IU/l). It was shown that occult HBV infection occurs in approximately 6% of patients. In most of them the protective levels of anti-HBs are detected.
Zaklad Wirusologii, Instytut Hematologii i Transfuzjologii w Warszawie.
Aneta
A
Kopacz
Anna
A
Bielecka
Maria
M
Mikulska
Piotr
P
Grabarczyk
Paulina
P
Zwolińska
Beata
B
Wojciechowska
Magdalena
M
Łetowska
Elzbieta
E
Kisiel
Krzysztof
K
Warzocha
Bernadetta
B
Ceglarek
Andrzej B
AB
Szczepanik
Andrzej
A
Szczepiński
Katarzyna
K
Owczarska
Konrad
K
Pielaciński
Ewa
E
Brojer
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000453:epidemiology*; D006512:Hepatitis B Core Antigens / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D015415:Biomarkers; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens