Copper-catalyzed alkene arylation with diaryliodonium salts.
Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Robert J
RJ
Phipps
Lindsay
L
McMurray
Stefanie
S
Ritter
Hung A
HA
Duong
Matthew J
MJ
Gaunt
D000475:Alkenes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009861:Onium Compounds / Q000737:chemistry*
D000475:Alkenes; D001555:Benzene Derivatives; D009861:Onium Compounds; D003300:Copper