Role of granulocyte/neutrophil transfusions for haematology/oncology patients in the modern era.
Infections continue to be a serious problem for severely neutropenic oncology and haematopoietic progenitor cell (HPC) transplant patients. Although it is now possible to collect much larger numbers of neutrophils (PMNs) from donors stimulated with granulocyte colony-stimulating factor + corticosteroids, the efficacy of these 'modern' granulocyte/PMN transfusions, with higher doses of PMNs, has not been established by convincing randomized control trials. Accordingly, they cannot be recommended for standard therapy at this time.
Department of Pathology & Pediatrics, University of Iowa College of Medicine, Iowa City, USA. ronald-strauss@uiowa.edu
Ronald G
RG
Strauss
D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006098:Granulocytes / Q000637:transplantation*; D006402:Hematologic Diseases / Q000628:therapy*; D006801:Humans; D017708:Leukocyte Transfusion / Q000379:methods; D009369:Neoplasms / Q000628:therapy*; D009504:Neutrophils / Q000637:transplantation*
D016179:Granulocyte Colony-Stimulating Factor