Assessing cell and organ senescence biomarkers.
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.
Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Madrid, Spain.
Bruno
B
Bernardes de Jesus
Maria A
MA
Blasco
D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D016922:Cellular Senescence / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D009857:Oncogenes; D010641:Phenotype; D016615:Telomere / Q000378:metabolism; D059506:Telomere Shortening
D015415:Biomarkers; D005819:Genetic Markers