Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channels.
The dopaminergic modulation of long-term potentiation (LTP) has been studied well, but the mechanism by which dopamine induces LTP (DA-LTP) in CA1 pyramidal neurons is unknown. Here, we report that DA-LTP in basal dendrites is dependent while in apical dendrites it is independent of activation of L-type voltage-gated calcium channels (VDCC). Activation via NMDAR is critical for the induction of DA-LTP in both apical and basal dendrites, but only BDNF is required for the induction and maintenance of DA-LTP in apical dendrites. We report that dopaminergic modulation of LTP is lamina-specific at the Schaffer collateral/commissural synapses in the CA1 region.
Division of Cellular Neurobiology, Zoological Institute, Braunschweig D-38106, Germany. sheejanavakkode@yahoo.com.uk
Sheeja
S
Navakkode
Sreedharan
S
Sajikumar
Martin
M
Korte
Tuck Wah
TW
Soong
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D001703:Biophysics; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism*; D003712:Dendrites / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D020813:Receptor, trkB / Q000494:pharmacology
D019208:Brain-Derived Neurotrophic Factor; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D018691:Excitatory Amino Acid Antagonists; D015763:2-Amino-5-phosphonovalerate; D020813:Receptor, trkB; D009543:Nifedipine; D004298:Dopamine