Common genetic variants in the microRNA biogenesis pathway are not associated with breast cancer risk in Asian women.
BACKGROUND
Although the role of miRNA in cancer development and progression has been well established, the association between genetic variants in miRNA biogenesis pathway genes and breast cancer risk has been yet unclear.


METHODS
We analyzed data from two genome-wide association studies conducted in East Asian women including 5,066 cases and 4,337 controls. Among the single-nucleotide polymorphisms (SNP), which were directly genotyped or imputed, we selected 237 SNPs in 32 genes involved in miRNA biogenesis pathway and its regulation.


RESULTS
Although eight SNPs were nominally associated with breast cancer risk in combined samples (P < 0.05), none of them were significant after adjustment for multiple comparisons.


CONCLUSIONS
The common genetic variants in miRNA biogenesis pathway genes may not be associated with breast cancer risk.


CONCLUSIONS
This study suggests no association between the polymorphisms in miRNA biogenesis pathway genes and breast cancer risk. Studies with large sample size and more genetic variants should be warranted to adequately evaluate the potential association.
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Hyuna
H
Sung
Ben
B
Zhang
Ji-Yeob
JY
Choi
Jirong
J
Long
Sue K
SK
Park
Keun-Young
KY
Yoo
Dong-Young
DY
Noh
Sei-Hyun
SH
Ahn
Wei
W
Zheng
Daehee
D
Kang
D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
D035683:MicroRNAs