Cell adhesion molecules in human embryo implantation.
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms, but also by a mechanism unique to humans. Evidence suggests that the cell adhesion molecules, L-selectin and trophinin, play a unique role in human embryo implantation. Here, we describe the dual roles of mucin carbohydrate ligand for L-selectin and trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells and endometrial epithelial cells. This review also covers cadherin and integrin in human embryo implantation.
Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA. michiko@burnham.org
Michiko N
MN
Fukuda
Kazuhiro
K
Sugihara
D015820:Cadherins / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D010064:Embryo Implantation; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000502:physiology; D019041:L-Selectin / Q000502:physiology; D015398:Signal Transduction
C112245:BYSL protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D016023:Integrins; C093649:TRO protein, human; C093648:TROAP protein, human; D019041:L-Selectin