Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model.
Chronic exposure of skin to ultraviolet (UV) B radiation induces oxidative stress, which in turn, plays a crucial role in the induction of skin aging. The search for strategies to reverse skin aging is being constantly pursued. Here, the cytoprotective effect of quercitrin (QR) on UVB-induced cell injury in HaCaT human keratinocytes and in the zebrafish was investigated. Intracellular reactive oxygen species (ROS) generated by the exposure of HaCaT cells to UVB radiation were significantly decreased after treatment with QR, and significantly so with QR at 50 μM. As a result, QR reduced UVB-induced cell death and apoptosis in HaCaT cells. QR similarly reduced UVB-induced ROS generation and cell death in live zebrafish.
Marine Bio Research Team, Korea Basic Science Institute (KBSI), Jeju 690-140, Republic of Korea.
Hye-Mi
HM
Yang
Young-Min
YM
Ham
Weon-Jong
WJ
Yoon
Seong Woon
SW
Roh
You-Jin
YJ
Jeon
Tatsuya
T
Oda
Sung-Myung
SM
Kang
Min-Cheol
MC
Kang
Eun-A
EA
Kim
Daekyung
D
Kim
Kil-Nam
KN
Kim
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002460:Cell Line; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays; D015027:Zebrafish / Q000254:growth & development
D017382:Reactive Oxygen Species; C012526:quercitrin; D011794:Quercetin