The photomorphogenic repressors COP1 and DET1: 20 years later.
COP1 and DET1 are among the first repressors of photomorphogenesis to be identified, more than 20 years ago. Discovery of these repressors as conserved regulators of the ubiquitin-proteasome system has established protein degradation as a central theme in light signal transduction. COP1 is a RING E3 ubiquitin ligase that targets key regulators for degradation, and DET1 complexes with COP10 and DDB1, which is proposed to aid in COP1-mediated degradation. Recent studies have strengthened the role of COP1 as a major signaling center. DET1 is also emerging as a chromatin regulator in repressing gene expression. Here, we review current understanding on COP1 and DET1, with a focus on their role as part of two distinct, multimeric CUL4-based E3 ligases.
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA.
On Sun
OS
Lau
Xing Wang
XW
Deng
D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics / Q000528:radiation effects; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002940:Circadian Rhythm; D044842:Cullin Proteins / Q000235:genetics / Q000378:metabolism; D035264:Flowers / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D056426:Genetic Loci; D047908:Intracellular Signaling Peptides and Proteins; D008027:Light; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D063245:Plant Development / Q000528:radiation effects*; D059748:Proteolysis; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*
D029681:Arabidopsis Proteins; C514806:CULLIN4 protein, Arabidopsis; D044842:Cullin Proteins; C088435:DET1 protein, Arabidopsis; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; C471983:AT2G32950 protein, Arabidopsis; D044767:Ubiquitin-Protein Ligases