Radioactive bone cement for the treatment of spinal metastases: a dosimetric analysis of simulated clinical scenarios.
Vertebral metastases are a common manifestation of many cancers, potentially leading to vertebral collapse and neurological complications. Conventional treatment often involves percutaneous vertebroplasty/kyphoplasty followed by external beam radiation therapy. As a more convenient alternative, we have introduced radioactive bone cement, i.e. bone cement incorporating a radionuclide. In this study, we used a previously developed Monte Carlo radiation transport modeling method to evaluate dose distributions from phosphorus-32 radioactive cement in simulated clinical scenarios. Isodose curves were generally concentric about the surface of bone cement injected into cadaveric vertebrae, indicating that dose distributions are relatively predictable, thus facilitating treatment planning (cement formulation and dosimetry method are patent pending). Model results indicated that a therapeutic dose could be delivered to tumor/bone within ∼4 mm of the cement surface while maintaining a safe dose to radiosensitive tissue beyond this distance. This therapeutic range should be sufficient to treat target volumes within the vertebral body when tumor ablation or other techniques are used to create a cavity into which the radioactive cement can be injected. With further development, treating spinal metastases with radioactive bone cement may become a clinically useful and convenient alternative to the conventional two-step approach of percutaneous strength restoration followed by radiotherapy.
Department of Radiological Sciences, B140 Med Sci I, University of California, Irvine, CA 92697, USA. tkaneko@uci.edu
T S
TS
Kaneko
V
V
Sehgal
H B
HB
Skinner
M S A L
MS
Al-Ghazi
N S
NS
Ramsinghani
M
M
Marquez Miranda
J H
JH
Keyak
D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D011874:Radiometry; D011879:Radiotherapy Dosage; D013131:Spine / Q000528:radiation effects
D001843:Bone Cements