Controlled delivery for neuro-bionic devices.
Implantable electrodes interface with the human body for a range of therapeutic as well as diagnostic applications. Here we provide an overview of controlled delivery strategies used in neuro-bionics. Controlled delivery of bioactive molecules has been used to minimise reactive cellular and tissue responses and/or promote nerve preservation and neurite outgrowth toward the implanted electrode. These effects are integral to establishing a chronically stable and effective electrode-neural communication. Drug-eluting bioactive coatings, organic conductive polymers, or integrated microfabricated drug delivery channels are strategies commonly used.
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, NSW 2522, Australia.
Zhilian
Z
Yue
Simon E
SE
Moulton
Mark
M
Cook
Stephen
S
O'Leary
Gordon G
GG
Wallace
D057005:Bioengineering / Q000295:instrumentation*; D016503:Drug Delivery Systems; D004567:Electrodes, Implanted; D006801:Humans; D011108:Polymers
D011108:Polymers