Collagen I confers gamma radiation resistance.
The effect of collagen on the response of somatomammotroph tumor cells (GH3) to gamma, radiation therapy was studied in vitro. After incubating confluent GH3 cell monolayers in a serum-free, maintaining medium, either with or without collagen, the monolayers were irradiated with 137Cs, gamma radiation. Collagen reduces cell mortality via ERK1/2 activation, abolishing gamma radiation, cell death, and promotes cell invasion when acting in synergy with collagen and in association with the, MAPK/ERK1/2 signaling pathway activation. The presence of collagen in somatomammotroph tumors, confers resistance to radiation.
Technology Research Management, Nuclear Research National Institute, Dr Nabor Carrillo Flores, Carr México-Toluca S/N La Marquesa, 52750 Ocoyoacac, Mexico. erica.azorin@inin.gob.mx
E
E
Azorin
P R
PR
González-Martínez
J
J
Azorin
D000818:Animals; D045744:Cell Line, Tumor; D024042:Collagen Type I / Q000494:pharmacology*; D005720:Gamma Rays; D020935:MAP Kinase Signaling System / Q000502:physiology; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance / Q000187:drug effects*; D051381:Rats
D024042:Collagen Type I