'Tumour-induced osteomalacia'.
A 60-year-old man presented 2 years before his diagnosis with long-standing muscle cramping, progressive generalised weakness and chronic hip pain. The patient was found to have bilateral femoral neck pathologic fractures therefore, underwent reamed intramedullary nailing of both femurs. Laboratory studies showed hypophosphataemia. Bone marrow biopsy was negative for malignancy. Positron emission tomography demonstrated fludeoxyglucose uptake only in the posterior neck. Bone scan showed innumerable foci of increased activity throughout the skeleton consistent with pseudofractures seen in osteomalacia. Fine needle aspiration from the mass in the neck revealed a phosphaturic mesenchymal tumour of mixed connective tissue type. Resection of the mass in the neck resulted in resolution of generalised complaints with no evidence of recurrence with a follow-up of 12 months.
Department of Hematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA. Javier.munoz@me.com
Javier
J
Munoz
Rosa
R
Michel Ortega
Florence
F
Celzo
Vijayalakshmi
V
Donthireddy
D006258:Head and Neck Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D010018:Osteomalacia / Q000209:etiology*; D049268:Positron-Emission Tomography