Development of innovative techniques for the endoscopic implantation and securing of a novel, wireless, miniature gastrostimulator (with videos).
BACKGROUND
Gastric stimulation via high-frequency, low-energy pulses can provide an effective treatment for gastric dysmotility; however, the current commercially available device requires surgical implantation for long-term stimulation and is powered by a nonrechargeable battery.


OBJECTIVE
To test and describe endoscopic implantation techniques and testing of stimulation of a novel, wireless, batteryless, gastric electrical stimulation (GES) device.


METHODS
Endoscopic gastric implantation techniques were implemented, and in vivo gastric signals were recorded and measured in a non-survival swine model (n = 2; 50-kg animals).


METHODS
Five novel endoscopic gastric implantation techniques and stimulation of a novel, wireless, batteryless, GES device were tested on a non-survival swine model.


METHODS
Feasibility of 5 new endoscopic gastric implantation techniques of the novel, miniature, batteryless, wireless GES device while recording and measurement of in vivo gastric signals.


RESULTS
All 5 of the novel endoscopic techniques permitted insertion and securing of the miniaturized gastrostimulator. By the help of these methods and miniaturization of the gastrostimulator, successful GES could be provided without any surgery. The metallic clip attachment was restricted to the mucosal surface, whereas the prototype tacks, prototype spring coils, percutaneous endoscopic gastrostomy wires/T-tag fasteners, and submucosal pocket endoscopic implantation methods attach the stimulator near transmurally or transmurally to the stomach. They allow more secure device attachment with optimal stimulation depth.


CONCLUSIONS
Non-survival pig studies.


CONCLUSIONS
These 5 techniques have the potential to augment the utility of GES as a treatment alternative, to provide an important prototype for other dysmotility treatment paradigms, and to yield insights for new technological interfaces between non-invasiveness and surgery.
Department of Electrical Engineering, University of Texas at Arlington, Arlington, Texas, USA.
Sanchali
S
Deb
Shou-jiang
SJ
Tang
Thomas L
TL
Abell
Tyler
T
McLawhorn
Wen-Ding
WD
Huang
Christopher
C
Lahr
S D Filip
SD
To
Julie
J
Easter
J-C
JC
Chiao
D000818:Animals; D004599:Electric Stimulation Therapy / Q000295:instrumentation; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D018589:Gastroparesis / Q000628:therapy; D058542:Implantable Neurostimulators; D008297:Male; D019919:Prosthesis Implantation / Q000379:methods*; D013270:Stomach / Q000502:physiology; D013552:Swine; D059015:Wireless Technology