Role of BAG3 protein in leukemia cell survival and response to therapy.
The ability of BAG3, a member of the BAG family of heat shock protein (Hsp) 70 - cochaperones, to sustain the survival of human primary B-CLL and ALL cells was recognized about nine years ago. Since then, the anti-apoptotic activity of BAG3 has been confirmed in other tumor types, where it has been shown to regulate the intracellular concentration and localization of apoptosis-regulating factors, including NF-κB-activating (IKKγ) and Bcl2-family (Bax) proteins. Furthermore, growing evidences support its role in lymphoid and myeloid leukemia response to therapy. Moreover in the last years, the contribution of BAG3 to autophagy, a process known to be involved in the pathogenesis and response to therapy of leukemia cells, has been disclosed, opening a new avenue for the interpretation of the role of this protein in leukemias' biology.
University of Salerno, Fisciano, Italy.
Alessandra
A
Rosati
Anna
A
Basile
Antonia
A
Falco
Morena
M
d'Avenia
Michelina
M
Festa
Vincenzo
V
Graziano
Vincenzo
V
De Laurenzi
Claudio
C
Arra
Maria
M
Pascale
Maria Caterina
MC
Turco
D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D001343:Autophagy; D002470:Cell Survival; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000628:therapy*
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C414431:BAG3 protein, human