BOLD responses to tactile stimuli in visual and auditory cortex depend on the frequency content of stimulation.
Although some brain areas preferentially process information from a particular sensory modality, these areas can also respond to other modalities. Here we used fMRI to show that such responsiveness to tactile stimuli depends on the temporal frequency of stimulation. Participants performed a tactile threshold-tracking task where the tip of either their left or right middle finger was stimulated at 3, 20, or 100 Hz. Whole-brain analysis revealed an effect of stimulus frequency in two regions: the auditory cortex and the visual cortex. The BOLD response in the auditory cortex was stronger during stimulation at hearable frequencies (20 and 100 Hz) whereas the response in the visual cortex was suppressed at infrasonic frequencies (3 Hz). Regardless of which hand was stimulated, the frequency-dependent effects were lateralized to the left auditory cortex and the right visual cortex. Furthermore, the frequency-dependent effects in both areas were abolished when the participants performed a visual task while receiving identical tactile stimulation as in the tactile threshold-tracking task. We interpret these findings in the context of the metamodal theory of brain function, which posits that brain areas contribute to sensory processing by performing specific computations regardless of input modality.
Department of Integrative Medical Biology, Physiology Section, Umeå University,SE 90187 Umeå, Sweden. per.nordmark@physiol.umu.se
Per F
PF
Nordmark
J Andrew
JA
Pruszynski
Roland S
RS
Johansson
D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D010812:Physical Stimulation / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D014110:Touch / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D055815:Young Adult