Coordination between RAB GTPase and phosphoinositide regulation and functions.
Membrane trafficking relies on dynamic changes in membrane identities that are determined by the regulation of distinct RAB GTPases and phosphoinositides. RABs and phosphoinositides both act to spatiotemporally recruit effectors of membrane remodelling, including sequential RAB and phosphoinositide activities. New ideas on coordinated regulation of specific RABs and phosphoinositides, achieved by direct physical and functional interactions between their regulatory enzymes, are emerging as a central mechanism to ensure precision and fidelity of membrane trafficking.
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA. sjean@ucsd.edu
Steve
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Jean
Amy A
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Kiger
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000737:chemistry*; D021381:Protein Transport; D020543:Proteome; D015398:Signal Transduction; D013997:Time Factors; D020691:rab GTP-Binding Proteins / Q000737:chemistry*
D010716:Phosphatidylinositols; D020543:Proteome; D020691:rab GTP-Binding Proteins