Intermolecular gold-catalyzed diastereo- and enantioselective [2+2+3] cycloadditions of 1,6-enynes with nitrones.
Going for gold: The title reaction has been developed and demonstrates a wide substrate scope with respect to the 1,6-enynes and nitrones (see scheme; DCE = 1,2-dichloroethane, Tf = trifluoromethanesulfonyl). The results for the enantioselective versions are also presented.
Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Sagar Ashok
SA
Gawade
Sabyasachi
S
Bhunia
Rai-Shung
RS
Liu
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000737:chemistry*; D050607:Organogold Compounds / Q000737:chemistry*; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000480:Alkynes; D009589:Nitrogen Oxides; D050607:Organogold Compounds; D010077:Oxazepines; C015388:nitrones; D006046:Gold