Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices.
Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery.
David H. Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, United States.
Yongtae
Y
Kim
Bomy
B
Lee Chung
Mingming
M
Ma
Willem J M
WJ
Mulder
Zahi A
ZA
Fayad
Omid C
OC
Farokhzad
Robert
R
Langer
D008055:Lipids / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
D008055:Lipids; D011108:Polymers