Cerium chloride improves protein and carbohydrate metabolism of fifth-instar larvae of Bombyx mori under phoxim toxicity.
The organophosphorus pesticide poisoning of the silkworm Bombyx mori is one of the major events causing serious damage to sericulture. Added low-dose rare earths are demonstrated to increase resistance in animals. However, very little is known about whether or not added CeCl₃ can increase resistance of silkworm to phoxim poisoning. The present findings suggested that added CeCl₃ to mulberry leaves markedly increased contents of protein, glucose and pyruvate, and carbohydrate metabolism-related enzyme activities, including lactate dehydrogenase, succinate dehydrogenase and malate dehydrogenase, and attenuated free amino acids, urea, uric acid and lactate levels and inhibited the protein metabolism-related enzymes activities, such as protease, alanine aminotransferase and aspartate aminotransferase in the haemolymph of B. mori, under phoxim toxicity. These findings suggest that added CeCl₃ may improve protein and carbohydrate metabolisms, thus leading to increases of growth and survival rate of B. mori under phoxim stress.
Medical college, Suzhou, 215123, People's Republic of China.
Bing
B
Li
Yi
Y
Xie
Zhe
Z
Cheng
Jie
J
Cheng
Rengping
R
Hu
Xuezi
X
Sang
Suxin
S
Gui
Qingqing
Q
Sun
Xiaolan
X
Gong
Yaling
Y
Cui
Weide
W
Shen
Fashui
F
Hong
D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D012831:Bombyx / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002563:Cerium / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D003433:Crosses, Genetic; D006458:Hemolymph / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D019476:Insect Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007305:Insecticide Resistance / Q000187:drug effects*; D007306:Insecticides / Q000037:antagonists & inhibitors; D045022:Lactate Dehydrogenases / Q000737:chemistry / Q000378:metabolism; D007814:Larva / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000037:antagonists & inhibitors*; D014176:Protein Biosynthesis / Q000187:drug effects; D059748:Proteolysis / Q000187:drug effects; D013385:Succinate Dehydrogenase / Q000737:chemistry / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D019476:Insect Proteins; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D002563:Cerium; C003135:phoxim; D045022:Lactate Dehydrogenases; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C026690:cerous chloride