pH-responsive NIR enhanced drug release from gold nanocages possesses high potency against cancer cells.
We report a smart therapeutic nanoplatform based on Fe(3)O(4)@CaP capped gold nanocages, which integrates magnetic targeting, photothermal therapy and chemotherapy for killing cancer cells. Combining photothermal- and chemo-therapy results in a synergistic effect in cancer treatment.
Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
Peng
P
Shi
Konggang
K
Qu
Jiasi
J
Wang
Meng
M
Li
Jinsong
J
Ren
Xiaogang
X
Qu
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D006046:Gold; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000628:therapy*
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D006046:Gold; D004317:Doxorubicin