[Morphological factors of productive and persistent developmental cycles of Chlamydia pneumoniae in human coronary and aortic endothelium].
Among 46 patients 39 died of cardial cause and 7--noncardial one. Chlamydia pneumonia (Ch-p) was founded out in aortal endothelium of 26 studied patients. Only 3 patients (11%) had the typical form of inclusions, 23 cases (89% of infected patients) had persistent form of inclusions in aortal endothelium. 7 patients had persistent form of inclusions in coronary epithelium. An acute myocardial infarction was accompanied by Ch-p (9 cases from 11). The productive form of Ch-p developmental cycle was accompanied by three types of inclusions: 1) typical (TI), 2) dystrophic (DI), 3) mixed. The persistent Ch-p developmental cycle was characterized by atypical inclusions (AI) with large reticular bodies, AI with small solitary bodies and mixed inclusions (MI). MI is simultaneous presence of TI and AI in cytoplasm of endothelium. MI could be evidence of Ch-p activation and transition from persistent to productive developmental cycle of infection. The main feature of Ch-p was its reproduction by constriction and budding of inclusions. The damaging effect of persistent Ch-p could be higher than productive form of Ch-p, because of large quantity of inclusion and increase of its membrane area, what crucial for intensive metabolism.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000382:microbiology / Q000473:pathology; D023521:Chlamydophila Infections / Q000473:pathology*; D016993:Chlamydophila pneumoniae; D003324:Coronary Artery Disease / Q000382:microbiology / Q000473:pathology; D003331:Coronary Vessels / Q000382:microbiology / Q000473:pathology; D004730:Endothelium, Vascular / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged