One pot synthesis of structurally different mono and dimeric Ni(II) thiosemicarbazone complexes and N-arylation on a coordinated ligand: a comparative biological study.
One pot synthesis of three structurally different Ni(II) thiosemicarbazone complexes 1, 2 and 3 were obtained from the reaction between [NiCl(2)(PPh(3))(2)], 1,2-bis(diphenylphosphino)ethane, and [H(2)-(Sal-tsc)]. The obtained products were characterized by various spectral and analytical techniques. From the X-ray crystallographic analysis, an unexpected N-arylation on the coordinated salicylaldehydethiosemicarbazone was found in complex 2. The comparative biological evolutions such as DNA/protein binding, antioxidant, cytotoxicity (MTT, LDH, and NO) and cellular uptake studies have been examined for [Ni(Sal-tsc)(PPh(3))] (1) and [(Ni(Sal-tsc))(2)(μ-dppe)] (3). When comparing the cytotoxicity of the complexes, 1 exhibited higher activity than 2 and 3 and by comparing with standard cis-platin, both of them were found to exhibit better activity under identical conditions.
Department of Chemistry, Bharathiar University, Coimbatore 641 046, India. rpnchemist@gmail.com
R
R
Prabhakaran
P
P
Kalaivani
P
P
Poornima
F
F
Dallemer
G
G
Paramaguru
V
V
Vijaya Padma
R
R
Renganathan
R
R
Huang
K
K
Natarajan
D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008024:Ligands; D009113:Muramidase / Q000378:metabolism; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D010851:Picrates / Q000737:chemistry; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
D001713:Biphenyl Compounds; D005609:Free Radicals; D008024:Ligands; D010851:Picrates; D013882:Thiosemicarbazones; D009569:Nitric Oxide; D009532:Nickel; D004247:DNA; C004931:1,1-diphenyl-2-picrylhydrazyl; D007770:L-Lactate Dehydrogenase; D009113:Muramidase