Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.
BACKGROUND
Atopic asthma, the most common chronic disease affecting children and young adults, is a complex disorder with variable phenotypes. Cysteine leukotrienes (Cys-LTs) are powerful bronchoconstrictors and play a critical role in airway inflammation and remodeling that are characteristic of asthma.


OBJECTIVE
To investigate the association of ALOX5, LTC4S and CysLTR2 gene polymorphisms with atopic asthma in an Indian population.


METHODS
A total of 19 single nucleotide polymorphisms (SNPs) within these genes were genotyped in a family-based cohort (n = 239) and a case-control cohort (139 cases and 194 controls) followed by association analyses.


RESULTS
We found a significant association of the -1072G/A (rs3776944) SNP with atopic asthma in the family-based association analysis (p = 0.0004). These results were also replicated in the case-control cohort (p = 0.009). The allele A was negatively associated with atopic asthma. We also noted a significant association in the two-locus (rs3776944G/A and rs730012A/C) haplotypic analysis of this gene both in the family-based (p = 0.03) and the case-control (p = 0.02) analyses.


CONCLUSIONS
This study supports the role of the LTC4S gene polymorphism in genetic susceptibility to atopic asthma in an Indian population.
Molecular Immunogenetics Laboratory and Center of Excellence for Translational Research in Asthma and Lung Disease, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Amrendra
A
Kumar
Shilpy
S
Sharma
Anurag
A
Agrawal
Balaram
B
Ghosh
D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000483:Alleles; D001249:Asthma / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D018077:Receptors, Leukotriene / Q000235:genetics / Q000276:immunology; D044465:White People
D058927:5-Lipoxygenase-Activating Proteins; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase