Primary synovial sarcoma involving the submandibular gland.
Synovial sarcoma represents 5.6%-10% of all soft-tissue sarcomas. Adolescents and young adults are most frequently affected, mainly in the deep soft tissue of the extremities. Only 10% of synovial sarcomas affect the head and neck region; most of these are biphasic. We describe a case of an 18-year-old man who complained of a mass in the right submandibular region that had been present for approximately 12 months. On surgical removal, microscopic analysis showed a tumor formed by sheets of malignant spindle cells involving the submandibular gland. Immunohistochemistry displayed positivity for AE1/AE3, CK18/8, epithelial membrane antigen, CD99, CD56, and TLE-1. Based on these immunohistochemical and histopathologic features, a diagnosis of monophasic synovial sarcoma was rendered. The patient was treated with adjuvant radiotherapy and after 1 year was free of disease. To the best of our knowledge, this is the first reported case of synovial sarcoma involving the submandibular gland.
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. nanda@fop.unicamp.br
Fernanda Viviane
FV
Mariano
Rogério
R
Oliveira Gondak
Matheus Vieira
MV
da Costa
Marcelo Brum
MB
Corrêa
Márcio Ajudarte
MA
Lopes
Oslei Paes
OP
de Almeida
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D013584:Sarcoma, Synovial / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D014463:Ultrasonography
D014408:Biomarkers, Tumor