Frequency of circulating autoreactive T cells committed to myelin determinants in relapsing-remitting multiple sclerosis patients.
Multiple sclerosis (MS) is considered as an autoimmune disease in which T cell reactivity to self-antigens expressed in the brain, particularly myelin antigens, plays a pivotal role. Various myelin-derived peptides, including peptides of myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) have been studied as putative target in MS. However, CD4(+) and CD8(+) T cells recognizing autoantigens from brain have been detected in the blood of MS patients as well as the blood of normal individuals. Here we review and discuss studies focused on the assessment of the frequency of autoreactive T cells responding to a given antigen using different assays including LDA, IFNγ-ELISPOT and TRAP (T cell Recognition of Antigen Presenting Cells by Protein transfer) in MS.
INSERM, UMR 643, Nantes, F44093, France.
Annie
A
Elong Ngono
Ségolène
S
Pettré
Marion
M
Salou
Bouchaib
B
Bahbouhi
Jean-Paul
JP
Soulillou
Sophie
S
Brouard
David-Axel
DA
Laplaud
D015551:Autoimmunity; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D006680:HLA Antigens