Immunotherapy: Is it different for sarcomas?
The Janus-faced roles of macrophages in cancer imply both tumor-suppressive and -stimulating actions of these innate immune cells. Whereas the balance is toward tumor promotion in most epithelial cancers, we have recently shown that osteosarcoma metastasis seems to be inhibited by macrophages. Here we discuss the possible mechanism of this observation.
Department of Pathology; Leiden University Medical Center; Leiden, The Netherlands.
Anne-Marie
AM
Cleton-Jansen
Emilie P
EP
Buddingh
Arjan C
AC
Lankester