Modular organization of the mammalian Golgi apparatus.
The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.
Department of Molecular Biosciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita, Kyoto 603-8555, Japan. osaru3@cc.kyoto-su.ac.jp
Nobuhiro
N
Nakamura
Jen-Hsuan
JH
Wei
Joachim
J
Seemann
D000818:Animals; D006056:Golgi Apparatus / Q000737:chemistry* / Q000378:metabolism*; D008322:Mammals