The faces and friends of RhoGDI2.
RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases that plays dual opposite roles in tumor progression, being both a promoter in tissues such as breast and a metastasis suppressor in tissues such as the bladder. Despite a clear role for this protein in modulating the invasive and metastatic process, the mechanisms through which RhoGDI2 executes these functions remain unclear. This review will highlight the current state of our knowledge regarding how RhoGDI2 functions in metastasis with a focus on bladder cancer and will also seek to highlight other potential underappreciated avenues through which this protein may affect cancer cell behavior.
Center for Cell Signaling and Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.
Erin M
EM
Griner
Dan
D
Theodorescu
D000818:Animals; D017209:Apoptosis; D019332:Endothelin-1 / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control; D051571:Protein Kinase C-alpha / Q000502:physiology; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D062949:rho Guanine Nucleotide Dissociation Inhibitor beta / Q000502:physiology*
D019332:Endothelin-1; D062949:rho Guanine Nucleotide Dissociation Inhibitor beta; C496628:PRKCA protein, human; D051571:Protein Kinase C-alpha; D020558:GTP Phosphohydrolases