Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides.
Aryl and heteroaryl boronic acids and boronate esters are rapidly, often within minutes, transformed into the corresponding phenols by N-oxides in an open flask at ambient temperature. This transformation has broad compatibility with a variety of functional groups.
Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. chen.zhu@utsouthwestern.edu
Chen
C
Zhu
Rui
R
Wang
J R
JR
Falck
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006900:Hydroxylation; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*
D000438:Alcohols; D001897:Boronic Acids; D004952:Esters; D010087:Oxides