[Simultaneous determination of four tanshinones in Salvia miltiorrhiza by QAMS].
OBJECTIVE
To establish a new method and validate its feasibilities for quality evaluation of Salvia miltiorrhiza.


METHODS
Four main effective components, dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone II(A), were selected as analytes to evaluate the quality of S. miltiorrhiza. The relative correction factors (RCF) of tanshinone II(A) to the other three tanshinones were calculated. The method was evaluated by comparison of the quantitative results between external standard method and QAMS method.


RESULTS
No significant differences were found in the quantitative results of four tanshinones by external standard method and QAMS method.


CONCLUSIONS
It is a convenient and accurate method to determine multi-components when some authentic standard substances were unavailable. It can be used to control the quality of S. miltiorrhiza.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine of Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Beijing 100193, China. lqaijiaren@126.com
Qian
Q
Li
Wei
W
Liu
Zuliang
Z
Luo
Meihua
M
Yang
D045784:Abietanes / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D008516:Medicine, Chinese Traditional; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012015:Reference Standards; D015203:Reproducibility of Results; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D045784:Abietanes; C021751:tanshinone