C-H activation: a complementary tool in the total synthesis of complex natural products.
The recent advent of transition-metal mediated C-H activation is revolutionizing the synthetic field and gradually infusing a "C-H activation mind-set" in both students and practitioners of organic synthesis. As a powerful testament of this emerging synthetic tool, applications of C-H activation in the context of total synthesis of complex natural products are beginning to blossom. Herein, recently completed total syntheses showcasing creative and ingenious incorporation of C-H activation as a strategic manoeuver are compared with their "non-C-H activation" counterparts, illuminating a new paradigm in strategic synthetic design.
Department of Chemistry, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea. davidchen@snu.ac.kr
David Y-K
DY
Chen
So Won
SW
Youn
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure
D001688:Biological Products