Effect of intraoperative amino acid infusion on blood glucose under general anesthesia combined with epidural block.
OBJECTIVE
To investigate the effect of intraoperative amino acid infusion on blood glucose in patients under general anesthesia combined with epidural block.


METHODS
36 patients were randomly assigned to receive an intraoperative infusion of 18 compound amino acids (group AA) or lactated Ringer solution (group LR) at 2 ml·kg(-1)·h(-1). Nasopharyngeal temperature, and blood glucose, plasma insulin, C-peptide and glucagon concentrations were measured 30 min before induction (T0), 10 min after induction (T1), 30 min and 2 h after skin incision (T2, T3), and 30 min and 2 h postoperatively (T4, T5).


RESULTS
Nasopharyngeal temperature values, which decreased during surgery in both groups, were significantly higher in group AA than in group LR from T3 to T5. Compared with T0, the blood glucose concentration increased significantly from T2 in group AA and T3 in group LR to T5. Plasma insulin and C-peptide concentrations did not change significantly in group LR, while both increased significantly in group AA from T1 to T4. The plasma glucagon concentration did not change significantly in either group.


CONCLUSIONS
Intraoperative amino acid infusion in patients under general anesthesia combined with epidural block may accelerate the increase of blood glucose concentration and stimulate insulin secretion, and can alleviate hypothermia during the later period of surgery and postoperatively.
Department of Anesthesia, Zhongshan Hospital, and Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, China.
Jing
J
Zhong
Sheng Jin
SJ
Ge
Xiao Feng
XF
Zhuang
Jing
J
Cang
Zhang Gang
ZG
Xue
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage*; D000767:Anesthesia, Epidural / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology / Q000517:prevention & control; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D000077325:Ringer's Lactate; D055815:Young Adult
D000596:Amino Acids; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D005934:Glucagon