The impact of human papillomavirus (HPV) types 6, 11 in women with genital warts.
OBJECTIVE
Human papillomaviruses (HPV) are etiologically associated with the development of virtually all genital warts. HPV-6 and HPV-11 are the most commonly detected HPV genotypes, but at least 20 other HPV genotypes have occasionally been found in genital wart tissue specimens.


METHODS
The aim of this study was to determine from 100 genital wart tissue specimens collected from female patients using multiplex gap-PCR technique the prevalence of various genital HPV among women with HPV genital warts in south of Iran. 100 genital wart tissue specimens were tested for the presence of HPV PG5/PG6 and also for HPV type using polymerase chain reaction (PCR).


RESULTS
Based on the collected data, 73 (73 %) samples were detected positive for HPV DNA and 23 (23 %) samples out of 100 samples were detected negative for HPV DNA. 49 (49 %) and 67 (67 %) of patients were detected positive for HPV type 6 and 11, respectively. There was a significant association between marital status and HPV genotype 6 (OR = 0.51, 95 % CI = 0.37-0.70, P = 0.01). Nevertheless, no significant association was found between marriage and HPV genotype 11 (OR = 0.85, 95 % CI = 0.58-1, 24, P = 0.7). Similarly, this result was demonstrated, in combined marriage and HPV-general (OR = 0.80, 95 % CI = 0.62-0.05, P = 0.4).


CONCLUSIONS
Concerning the prevalence of HPV in our study, determination of genital HPV prevalence and multiple infections among the normal population of women of Hormozgan Province is recommended.
Infections Research Center, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran.
Mahin
M
Jamshidi
Mohammad
M
Shekari
Abdol Azim
AA
Nejatizadeh
Keyanoush
K
Malekzadeh
Mahnaz
M
Baghershiroodi
Parivash
P
Davudian
Farzaneh
F
Dehghan
Froogh
F
Jamshidi
D000328:Adult; D003218:Condylomata Acuminata / Q000453:epidemiology* / Q000821:virology*; D016001:Confidence Intervals; D004279:DNA, Viral / Q000378:metabolism; D005260:Female; D005838:Genotype; D052140:Human papillomavirus 11 / Q000235:genetics; D052163:Human papillomavirus 6 / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D017533:Marital Status; D016017:Odds Ratio; D015995:Prevalence; D055815:Young Adult
D004279:DNA, Viral