Gluten-dependent intestinal autoimmune response.
Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.
Department of Pediatrics, University of Debrecen, Nagyerdei krt 98, H-4012 Debrecen, Hungary. ilma.korponay-szabo@uta.fi
Ilma Rita
IR
Korponay-Szabó
Zsafia
Z
Simon-Vecsei
Luigina
L
De Leo
Tarcisio
T
Not
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D005903:Gliadin / Q000276:immunology; D005983:Glutens / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D005983:Glutens; D005903:Gliadin; D011503:Transglutaminases