Viral modulation of stress granules.
Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production. In the last decade, several reports have shown that viruses modulate the assembly of stress granules (SGs), which are translationally silent ribonucleoproteins (RNPs) and sites of RNA triage. This review discusses recent advances in our understanding of the interactions between viruses and the host response and how virus-induced modulations in SG abundance play fundamental roles in dictating the success of viral replication.
HIV-1 RNA Trafficking Laboratory, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec H3T 1E2, Canada.
Fernando
F
Valiente-Echeverría
Luca
L
Melnychuk
Andrew J
AJ
Mouland
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D010944:Plants; D012367:RNA, Viral / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000276:immunology*
D012367:RNA, Viral; D012261:Ribonucleoproteins