title: Serum kinetics, distribution and excretion of silver in rabbits following 28 days after a single intravenous injection of silver nanoparticles.
abstract: Serum kinetics, tissue distribution, and excretion of citrate-coated silver nanoparticles (AgNPs) were investigated in rabbits (n = 4) up to 28 days after a single intravenous injection. Following a single injection of AgNPs, the AUC(last) was reported to be 3.65 ± 0.68 μg·day/ml in 5 mg/kg-treated group and 0.90 ± 0.16 μg·day/ml in 0.5 mg/kg-treated group, respectively. The accumulation of silver was observed in all the tested organs including liver, kidney, spleen, lung, brain, testis, and thymus at 1 day, 7 day, and 28 day of measurement. The liver and spleen seemed to be the major targets because of high accumulation of silver. Excretion via feces and urine was also monitored during the entire experimental period. Unexpectedly, much more excretion of silver occurred via feces than through urine after an intravenous injection, which suggests biliary excretion of AgNPs. General toxicity was analyzed and histopathological changes were also evaluated.
authors: College of Pharmacy, Dongduk Women's University, Seoul 136-714, Korea.
authors: Yeonjin
authors: Y
authors: Lee
authors: Pilje
authors: P
authors: Kim
authors: Junheon
authors: J
authors: Yoon
authors: Byoungcheun
authors: B
authors: Lee
authors: Kyunghee
authors: K
authors: Choi
authors: Ki-Hyun
authors: KH
authors: Kil
authors: Kwangsik
authors: K
authors: Park
mesh_terms: D000818:Animals; D019540:Area Under Curve; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D007275:Injections, Intravenous; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits; D012834:Silver / Q000097:blood / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D013047:Specific Pathogen-Free Organisms; D014018:Tissue Distribution; D018675:Toxicity Tests
chemical_list: D012834:Silver