title: Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.
abstract: This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP. Alterations to phosphatidylinositol 4-kinase expression levels can modulate MAP kinase and Akt signalling, and are important for chemoresistance, tumour angiogenesis and the suppression of apoptosis and metastases. Recent improvements in high-throughput screening assays, and the discoveries that some anti-viral molecules are isoform selective phosphatidylinositol 4-kinase inhibitors have advanced the drugability of these enzymes.
authors: UCL Institute of Liver and Digestive Health, Royal Free Campus, London, United Kingdom. m.waugh@ucl.ac.uk
authors: Mark G
authors: MG
authors: Waugh
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase / Q000502:physiology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D019008:Drug Resistance, Neoplasm; D057166:High-Throughput Screening Assays; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008840:Microfilament Proteins / Q000502:physiology; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D018129:Phosphatidylinositol Phosphates / Q000502:physiology*; D010743:Phospholipids / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; C502451:CCDC88A protein, human; D008563:Membrane Lipids; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D018129:Phosphatidylinositol Phosphates; D010743:Phospholipids; D033921:Vesicular Transport Proteins; C037178:phosphatidylinositol 4-phosphate; D019869:Phosphatidylinositol 3-Kinases; D019870:1-Phosphatidylinositol 4-Kinase; D010738:Type C Phospholipases