title: Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer.
abstract: We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.
authors: Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
authors: Dokyoon
authors: D
authors: Kim
authors: Department of Mechanical Engineering, Stanford University, Stanford, CA, 94305, USA.
authors: Jung-Rok
authors: JR
authors: Lee
authors: Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
authors: Eric
authors: E
authors: Shen
authors: Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA. sxwang@stanford.edu.|Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA. sxwang@stanford.edu.
authors: Shan X
authors: SX
authors: Wang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000295:instrumentation*; D004581:Electronics; D004781:Environmental Exposure / Q000032:analysis*; D060328:Magnetic Phenomena; D008962:Models, Theoretical; D053758:Nanoparticles; D036103:Nanotechnology / Q000295:instrumentation*; D009369:Neoplasms / Q000175:diagnosis*
chemical_list: D015415:Biomarkers