title: Neurofibromatosis type 1 associated with papillary thyroid carcinoma incidentally detected by thyroid ultrasonography: a case report.
abstract: BACKGROUND
  Neurofibromatosis type 1 is a common heritable neurocutaneous disorder. Neurofibromatosis type 1 may be associated with tumors of the central nervous system and pheochromocytoma. However, papillary thyroid carcinoma associated with neurofibromatosis type 1 is very rare. We present what is, to the best of our knowledge, the first case of papillary thyroid carcinoma to be detected incidentally by ultrasonography in a patient with neurofibromatosis type 1.
  
  
  METHODS
  A 63-year-old South Korean man with neurofibromatosis type 1 presented to our study hospital because of thyroid nodules detected incidentally by ultrasonography. Papillary thyroid carcinoma was diagnosed by ultrasonography-guided fine-needle aspiration, and then a total thyroidectomy with central compartment neck dissection was performed. The B isoform of the RafV600E mutation was identified by multiplex real-time polymerase chain reaction assay.
  
  
  CONCLUSIONS
  Papillary thyroid carcinoma associated with neurofibromatosis type 1 is very rare. However, it is speculated that papillary thyroid carcinoma is more likely to be detected in patients with neurofibromatosis type 1 if screening by ultrasonography is performed for them.
authors: Department of Internal Medicine, Kosin University College of Medicine, 262 Gamcheon Street SeoGu, Busan, 602-703, South Korea. yschoi@kosinmed.or.kr.
authors: Bu Kyung
authors: BK
authors: Kim
authors: Young Sik
authors: YS
authors: Choi
authors: Sangeon
authors: S
authors: Gwoo
authors: Yo Han
authors: YH
authors: Park
authors: Song I
authors: SI
authors: Yang
authors: Jeong Hoon
authors: JH
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