title: Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II).
abstract: Formulation of liposome delivery system loaded with water insoluble 2-(4-(tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II), LipoTHP-C11 was carried out. The particle size distributions were determined by dynamic light scattering and asymmetrical flow field-flow fractionation indicating size of around 120 nm. Stability study showed that LipoTHP-C11 was stable at 4 °C for more than two months. To test suitability of chosen formulation, LipoTHP-C11 was investigated against several tumor cell lines: H12.1, 1411HP, 518A2, A549, HT-29, MCF-7 and SW1736. Furthermore, toxicity against normal fibroblasts was examined. LipoTHP-C11 may be used as an attractive candidate for further assessment in vivo as antitumor agent.
authors: Biozentrum, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 22, D-06120 Halle, Germany. goran.kaluderovic@chemie.uni-halle.de
authors: Goran N
authors: GN
authors: Kaluđerović
authors: Andrea
authors: A
authors: Dietrich
authors: Harish
authors: H
authors: Kommera
authors: Judith
authors: J
authors: Kuntsche
authors: Karsten
authors: K
authors: Mäder
authors: Thomas
authors: T
authors: Mueller
authors: Reinhard
authors: R
authors: Paschke
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008081:Liposomes; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: C576615:2-(4-(tetrahydro-2H-pyran-2-yloxy)undecyl)propane-1,3-diamminedichloroplatinum(II); D000970:Antineoplastic Agents; D008081:Liposomes; D009944:Organoplatinum Compounds; D014867:Water