title: Association of the IL-10 polymorphisms and periodontitis: a meta-analysis.
abstract: No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case-control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 -1082 (-1087) A>G, -819 (-824) C>T and -592 (-597) C>A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95 % confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive "per-allele" model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case-control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 -819 (-824) C>T and IL-10 -592 (-597) C>A polymorphisms in Caucasians. The IL-10 -819 (-824) T and -592 (-597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.
authors: Centre of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Institute for Biotechnology and Bioengineering (CGB-UTAD/IBB), Quinta dos Prados, P.O. Box 1013, 5001-801 Vila Real, Portugal. cmralb@hotmail.com
authors: C M
authors: CM
authors: Albuquerque
authors: A J
authors: AJ
authors: Cortinhas
authors: F J
authors: FJ
authors: Morinha
authors: J C
authors: JC
authors: Leitão
authors: C A
authors: CA
authors: Viegas
authors: E M
authors: EM
authors: Bastos
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015810:Linkage Disequilibrium; D010518:Periodontitis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012306:Risk
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10