title: Rash, hepatotoxicity and hyperbilirubinemia among Kenyan infants born to HIV-infected women receiving triple-antiretroviral drugs for the prevention of mother-to-child HIV transmission.
abstract: We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.
authors: Epidemic Intelligence Service and †Division of HIV/AIDS Prevention, CDC, Atlanta, GA, USA. iyo4@cdc.gov
authors: Timothy D
authors: TD
authors: Minniear
authors: Clement
authors: C
authors: Zeh
authors: Nicholas
authors: N
authors: Polle
authors: Rose
authors: R
authors: Masaba
authors: Philip J
authors: PJ
authors: Peters
authors: Boaz
authors: B
authors: Oyaro
authors: Benta
authors: B
authors: Akoth
authors: Richard
authors: R
authors: Ndivo
authors: Frank
authors: F
authors: Angira
authors: Lisa A
authors: LA
authors: Mills
authors: Timothy K
authors: TK
authors: Thomas
mesh_terms: D000328:Adult; D019588:Aging, Premature; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced*; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007630:Kenya / Q000453:epidemiology; D019888:Nelfinavir / Q000009:adverse effects / Q000627:therapeutic use; D019829:Nevirapine / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D019380:Anti-HIV Agents; D019829:Nevirapine; D019888:Nelfinavir