title: Supramolecular core-shell nanosilica@liposome nanocapsules for drug delivery.
abstract: The fabrication of core-shell structural nanosilica@liposome nanocapsules as a drug delivery vehicle is reported. SiO(2) nanoparticles are encapsulated within liposomes by a W/O/W emulsion approach to form supramolecular assemblies with a core of colloidal particles enveloped by a lipid bilayer shell. A nanosilica core provides charge compensation and architectural support for the lipid bilayer, which significantly improves their physical stability. A preliminary application of these core-shell nanocapsules for hemoglobin (Hb) delivery is described. Through the H-bonding interaction between the hydroxyl groups on nanosilicas and the amino nitrogens of Hb, Hb-SiO(2) nanocomplexes in which the saturated adsorption amount of Hb on SiO(2) is 0.47 g g(-1) are coated with lipids to generate core-shell Hb-SiO(2)@liposome nanocapsules with mean diameters of 60-500 nm and Hb encapsulation efficiency of 48.4-87.9%. Hb-SiO(2)@liposome supramolecular nanovehicles create a mode of delivery that stabilizes the encapsulated Hb and achieves long-lasting release, thereby improving the efficacy of the drug. Compared with liposome-encapsulated Hb and Hb-loaded SiO(2) particles, such core-shell nanovehicles show substantially enhanced release performance of Hb in vitro. This finding opens up a new window of liposome-based formulations as drug delivery nanovehicles for widespread pharmaceutical applications.
authors: Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, PR China.
authors: Mingxian
authors: M
authors: Liu
authors: Lihua
authors: L
authors: Gan
authors: Liuhua
authors: L
authors: Chen
authors: Zijie
authors: Z
authors: Xu
authors: Dazhang
authors: D
authors: Zhu
authors: Zhixian
authors: Z
authors: Hao
authors: Longwu
authors: L
authors: Chen
mesh_terms: D000327:Adsorption; D016503:Drug Delivery Systems; D006454:Hemoglobins / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D006454:Hemoglobins; D008081:Liposomes; D046911:Macromolecular Substances; D012822:Silicon Dioxide