title: Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas.
abstract: A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed.
authors: Department of Applied Chemistry, National Chiao Tung University, Hsinchu 30050, Taiwan.
authors: Tsai-Wen
authors: TW
authors: Chung
authors: Chih-Hau
authors: CH
authors: Chen
authors: Chu-Chung
authors: CC
authors: Lin
authors: Hsien-Jen
authors: HJ
authors: Wu
authors: Chung-Ming
authors: CM
authors: Sun
authors: Wen-Sheng
authors: WS
authors: Chung
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D001554:Benzene / Q000138:chemical synthesis / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D013449:Sulfonamides; D013450:Sulfones; D014508:Urea; D000535:Aluminum; D001554:Benzene