title: Enantioselective synthesis of levomilnacipran.
abstract: A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.
authors: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191 Gif-sur-Yvette, France.
authors: Julien
authors: J
authors: Alliot
authors: Edmond
authors: E
authors: Gravel
authors: Florence
authors: F
authors: Pillon
authors: David-Alexandre
authors: DA
authors: Buisson
authors: Marc
authors: M
authors: Nicolas
authors: Eric
authors: E
authors: Doris
mesh_terms: D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry*; D000078764:Milnacipran; D010648:Phenylacetates / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000928:Antidepressive Agents; D003521:Cyclopropanes; D010648:Phenylacetates; C030797:cyclopropane; C025136:phenylacetic acid; D000078764:Milnacipran