title: Palladium-catalyzed N-monoarylation of amidines and a one-pot synthesis of quinazoline derivatives.
abstract: A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.
authors: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors: Meredeth A
authors: MA
authors: McGowan
authors: Camille Z
authors: CZ
authors: McAvoy
authors: Stephen L
authors: SL
authors: Buchwald
mesh_terms: D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000578:Amidines; D006846:Hydrocarbons, Halogenated; D011799:Quinazolines; D010165:Palladium