title: Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns.
abstract: Nationally, newborn screening programs use 17-hydroxyprogesterone (17-OHP) as the biomarker to detect the rare but potentially fatal inherited disease, congenital adrenal hyperplasia. However, this biomarker is highly variable, with a high false-positive rate of detection, particularly in neonates born preterm. Several studies have examined various clinical and genetic factors to explain the variability of 17-OHP in preterm infants. The purpose of this study was to replicate previous clinical and genetic associations with 17-OHP in a well-characterized cohort of 762 preterm infants. We replicated previous findings that respiratory distress syndrome (p = 2 x 10(-3)) is associated with higher 17-OHP. Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate.
authors: Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. kelli-ryckman@uiowa.edu
authors: Kelli K
authors: KK
authors: Ryckman
authors: Daniel E
authors: DE
authors: Cook
authors: Stanton L
authors: SL
authors: Berberich
authors: Oleg A
authors: OA
authors: Shchelochkov
authors: Susan K
authors: SK
authors: Berends
authors: Tamara
authors: T
authors: Busch
authors: John M
authors: JM
authors: Dagle
authors: Jeffrey C
authors: JC
authors: Murray
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D001724:Birth Weight; D004247:DNA / Q000097:blood / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D015997:Neonatal Screening; D011379:Prognosis; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D012189:Retrospective Studies
chemical_list: D019326:17-alpha-Hydroxyprogesterone; D004247:DNA