title: HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease.
abstract: Several studies showed increased oxidative and nitrosative stress in plasma from patients with Alzheimer's disease (AD), however, little and controversial knowledge has emerged about the antioxidant functionality of the heme oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system in blood. The current study reports increased levels of both HO-1 and BVR-A in plasma from probable AD patients, as a result of the increased oxidative environment. However, the increase of oxidative stress in plasma result also in the increase of BVR-A 3-nitrotyrosine levels and the decrease of BVR-A phosphotyrosine levels and reductase activity, suggesting that nitrosative stress play the prominent oxidative role in plasma during AD. Our data on HO-1/BVR-A status in plasma closely correlate with recent reports in hippocampus of subjects with AD and arguably its early form, mild cognitive impairment. Moreover, we show that alterations on HO-1/BVR-A system are tightly connected with cognitive decline indexed by Mini-Mental Status Exam scores. We hypothesize that the HO-1/BVR-A system status in plasma might reflect the ongoing situation in the brain, offering an important biochemical tool for the potential prediction of AD at the earliest stages of the disease.
authors: Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy. fabio.didomenico@uniroma1.it
authors: Fabio
authors: F
authors: Di Domenico
authors: Eugenio
authors: E
authors: Barone
authors: Cesare
authors: C
authors: Mancuso
authors: Marzia
authors: M
authors: Perluigi
authors: Annalisa
authors: A
authors: Cocciolo
authors: Patrizia
authors: P
authors: Mecocci
authors: D Allan
authors: DA
authors: Butterfield
authors: Raffaella
authors: R
authors: Coccia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000097:blood / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D018384:Oxidative Stress; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D051547:Heme Oxygenase-1; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019789:biliverdin reductase