title: Life-threatening disseminated tuberculosis as a complication of treatment by infliximab for Crohn's disease: report of two cases, including cerebral tuberculomas and miliary tuberculosis.
abstract: Tumor necrosis factor α antagonist therapies represent an increased risk of reactivation of tuberculosis. We report two cases of life-threatening disseminated tuberculosis in patients undergoing treatment with infliximab for Crohn's disease including one case of a patient with cerebral tuberculomas. We discuss the implication of tumor necrosis factor α in the genesis of tuberculosis infection and the features of tuberculosis under infliximab. Tuberculosis screening and eventually preventive chemotherapy should become the standard of care for individual undergoing tumor necrosis factor α antagonist therapies.
authors: Service de pneumologie et d'oncologie thoracique, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite Cedex, France.
authors: Claire
authors: C
authors: Tissot
authors: Sébastien
authors: S
authors: Couraud
authors: Lun
authors: L
authors: Meng
authors: Philippe
authors: P
authors: Girard
authors: Virginie
authors: V
authors: Avrillon
authors: Laurence
authors: L
authors: Gérinière
authors: Emilie
authors: E
authors: Perrot
authors: Pierre-Jean
authors: PJ
authors: Souquet
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology*; D054022:Cerebrum; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D012008:Recurrence; D014375:Tuberculoma / Q000188:drug therapy / Q000209:etiology*; D016862:Tuberculoma, Intracranial / Q000188:drug therapy / Q000209:etiology; D014391:Tuberculosis, Miliary / Q000188:drug therapy / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab