title: The molecular circuitry underlying pluripotency in embryonic stem cells.
abstract: Cells in the pluripotent state have the ability to self-renew indefinitely and to differentiate to all the cells of the embryo. These cells provide an in vitro window into development, including human development, as well as holding extraordinary promise for cell-based therapies in regenerative medicine. The recent demonstration that somatic cells can be reprogrammed to the pluripotent state has raised the possibility of patient and disease-specific induced pluripotent cells. In this article, we review the molecular underpinning of pluripotency. We focus on the transcriptional and signaling networks that underlie the state of pluripotency and control differentiation. In general, the action of each of the molecular components and pathways is dose and context dependent highlighting the need for a systems approach to understanding pluripotency.
authors: Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY, USA.
authors: Aryeh
authors: A
authors: Warmflash
authors: Brigitte L
authors: BL
authors: Arduini
authors: Ali H
authors: AH
authors: Brivanlou
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D044968:Regenerative Medicine; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors