title: Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins.
abstract: The high industrial relevance of the soil bacterium Bacillus megaterium as host for recombinant proteins is driving systems-wide analyses of its metabolic and regulatory networks. The present review highlights novel systems biology tools available to unravel the various cellular components on the level of metabolic and regulatory networks. These provide a rational platform for systems metabolic engineering of B. megaterium. In line, a number of interesting studies have particularly focused on studying recombinant B. megaterium in its industrial bioprocess environment thus integrating systems metabolic engineering with systems biotechnology and providing the full picture toward optimal processes.
authors: Institute of Biochemical Engineering, Technische Universität Braunschweig, Braunschweig, Germany.
authors: Claudia
authors: C
authors: Korneli
authors: Florian
authors: F
authors: David
authors: Rebekka
authors: R
authors: Biedendieck
authors: Dieter
authors: D
authors: Jahn
authors: Christoph
authors: C
authors: Wittmann
mesh_terms: D001410:Bacillus megaterium / Q000235:genetics / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D060847:Metabolic Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics; D049490:Systems Biology
chemical_list: D011994:Recombinant Proteins