title: Gastroprotective effect of selenium on ethanol-induced gastric damage in rats.
abstract: In the present study, we examined the gastroprotective effect of selenium against ethanol-induced gastric mucosal lesions in rats. The gastric mucosal lesions were produced by oral administration with various concentrations of ethanol for three days, and 80% ethanol treatment was determined to be the optimal condition for induction of gastric damage. To identify the protective effect of selenium on ethanol-induced gastric damage, various doses of selenium were given as pretreatment for three days, and then gastric damage was induced by 80% ethanol treatment. Selenium showed a protective effect against ethanol-induced gastric mucosal lesions in a dose dependent manner. Specifically, 100 μg/kg selenium showed the highest level of gastroprotection. In addition, selenium markedly attenuated ethanol-induced lipid peroxidation in gastric mucosa and increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. Histological data showed that 100 μg/kg selenium distinctly reduced the depth and severity of the ethanol induced gastric lesion. These results clearly demonstrate that selenium inhibits the formation of ethanol-induced gastric mucosal lesions through prevention of lipid peroxidation and activation of enzymatic radical scavenging.
authors: Department of Biomaterial Control (BK21 Program), Dong-Eui University Graduate School, Busan 614-714, Korea.
authors: Jeong-Hwan
authors: JH
authors: Kim
authors: Department of Pathology, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea.
authors: Shin-Hyung
authors: SH
authors: Park
authors: Department of Biomaterial Control (BK21 Program), Dong-Eui University Graduate School, Busan 614-714, Korea.|Department of Biotechnology and Bioengineering, Dong-Eui University, Busan 614-714, Korea.|Blue-Bio Industry RIC, Dong-Eui University, Busan 614-714, Korea.
authors: Soo-Wan
authors: SW
authors: Nam
authors: Blue-Bio Industry RIC, Dong-Eui University, Busan 614-714, Korea.|Anti-Aging Research Center, Dong-Eui University, Busan 614-714, Korea.|Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Korea.
authors: Yung-Hyun
authors: 0000-0002-1454-3124
authors: YH
authors: Choi
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D020011:Protective Agents; D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium