title: Preformed donor HLA-DP-specific antibodies mediate acute and chronic antibody-mediated rejection following renal transplantation.
abstract: Donor-specific HLA alloantibodies may cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. The clinical relevance of antibodies directed against some HLA class II antigens, particularly HLA-DP, is less clear with conflicting reports on their pathogenicity. We report two patients with high levels of pretransplant donor-specific HLA-DP antibodies who subsequently developed recurrent acute AMR and graft failure. In both cases, there were no other donor-specific HLA alloantibodies, suggesting that the HLA-DP-specific antibodies may be directly pathogenic.
authors: Division of Renal Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors: E C
authors: EC
authors: Jolly
authors: T
authors: T
authors: Key
authors: H
authors: H
authors: Rasheed
authors: H
authors: H
authors: Morgan
authors: A
authors: A
authors: Butler
authors: N
authors: N
authors: Pritchard
authors: C J
authors: CJ
authors: Taylor
authors: M R
authors: MR
authors: Clatworthy
mesh_terms: D000328:Adult; D006084:Graft Rejection / Q000276:immunology*; D006682:HLA-DP Antigens / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male
chemical_list: D006682:HLA-DP Antigens