title: Quantitative short echo time 1H MRSI of the peripheral edematous region of human brain tumors in the differentiation between glioblastoma, metastasis, and meningioma.
abstract: OBJECTIVE
  To assess metabolite levels in peritumoral edematous (PO) and surrounding apparently normal (SAN) brain regions of glioblastoma, metastasis, and meningioma in humans with (1)H-MRSI to find biomarkers that can discriminate between tumors and characterize infiltrative tumor growth.
  
  
  METHODS
  Magnetic resonance (MR) spectra (semi-LASER MRSI, 30 msec echo time, 3T) were selected from regions of interest (ROIs) under MRI guidance, and after quality control of MR spectra. Statistical testing between patient groups was performed for mean metabolite ratios of an entire ROI and for the highest value within that ROI.
  
  
  RESULTS
  The highest ratios of the level of choline compounds and the sum of myo-inositol and glycine over N-acetylaspartate and creatine compounds were significantly increased in PO regions of glioblastoma versus that of metastasis and meningioma. In the SAN region of glioblastoma some of these ratios were increased. Differences were less prominent for metabolite levels averaged over entire ROIs.
  
  
  CONCLUSIONS
  Specific metabolite ratios in PO and SAN regions can be used to discriminate glioblastoma from metastasis and meningioma. An analysis of these ratios averaged over entire ROIs and those with most abnormal values indicates that infiltrative tumor growth in glioblastoma is inhomogeneous and extends into the SAN region.
authors: Department of Radiology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.
authors: J P
authors: JP
authors: Wijnen
authors: A J S
authors: AJ
authors: Idema
authors: M
authors: M
authors: Stawicki
authors: M W
authors: MW
authors: Lagemaat
authors: P
authors: P
authors: Wesseling
authors: A J
authors: AJ
authors: Wright
authors: T W J
authors: TW
authors: Scheenen
authors: A
authors: A
authors: Heerschap
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000556:secondary*; D008875:Middle Aged; D011522:Protons
chemical_list: D015415:Biomarkers; D011522:Protons