title: Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotyping.
abstract: A consensus conference was held in order to provide guidelines for the use of adjuvant therapy in patients with Stage I carcinoma of the breast, using traditional information, such as tumor size, microscopic character, Nottingham index, patient age and co-morbidities, but also incorporating steroid hormone and Her-2-neu data as well as other immunohistochemical markers. The role of the genetic analysis of breast cancer and proprietary gene prognostic signatures was discussed, along with the molecular profiling of breast cancers into several groups that may predict prognosis. These molecular data are not currently sufficiently mature to make them part of decision making algorithms of recommendations for the treatment of individual patients.
authors: Breast Care Center, Professor of Surgery & Medical Oncology, Jefferson Medical College, Philadelphia, PA 19107, USA. Gordon.schwartz@jefferson.edu
authors: Gordon F
authors: GF
authors: Schwartz
authors: Harry
authors: H
authors: Bartelink
authors: Harold J
authors: HJ
authors: Burstein
authors: Blake
authors: B
authors: Cady
authors: Luigi
authors: L
authors: Cataliotti
authors: Ian S
authors: IS
authors: Fentiman
authors: Roland
authors: R
authors: Holland
authors: Kevin S
authors: KS
authors: Hughes
authors: Shahla
authors: S
authors: Masood
authors: Beryl
authors: B
authors: McCormick
authors: Juan A
authors: JA
authors: Palazzo
authors: Peter I
authors: PI
authors: Pressman
authors: Jorge
authors: J
authors: Reis-Filho
authors: Lajos
authors: L
authors: Pusztai
authors: Emiel J T
authors: EJ
authors: Rutgers
authors: Andrew D
authors: AD
authors: Seidman
authors: Lawrence J
authors: LJ
authors: Solin
authors: Joseph A
authors: JA
authors: Sparano
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005820:Genetic Testing; D006801:Humans; D061206:Neoplasm Micrometastasis; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D021701:Sentinel Lymph Node Biopsy; D059467:Transcriptome
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human