title: The correlation between hepatitis B virus infection and IL-27.
abstract: OBJECTIVE
  To investigate the correlation between HBV infection and interleukin 27 (IL-27).
  
  
  METHODS
  Serum IL-27 levels in patients with HBV infection and in healthy individuals were measured by ELISA, regulation of IL-27 by HBV in vitro were analyzed by RT-PCR and ELISA.
  
  
  RESULTS
  IL-27 was significantly elevated in patients as compared to healthy individuals (P<0.001). IL-27 was also detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with acute hepatitis B or chronic hepatitis B (P<0.05). We also found that IL-27 expression was influenced by HBV e antigen. In addition, our in vitro studies demonstrated that mRNA and protein expression were all stimulated in cells transfected with infectious HBV clone.
  
  
  CONCLUSIONS
  IL-27 would be a novel cytokine for clinical management of HBV-infected patients, which may establish novel HBV therapeutic approaches.
authors: Department of Clinical Laboratory, Huangshi Central Hospital, Huangshi, China. jy69970@163.com
authors: Hong-Liang
authors: HL
authors: Wang
authors: Hai-Yan
authors: HY
authors: Zhang
authors: Zhong-Liang
authors: ZL
authors: Zhai
authors: Xin
authors: X
authors: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D005260:Female; D005786:Gene Expression Regulation; D006509:Hepatitis B / Q000097:blood / Q000235:genetics / Q000276:immunology*; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D006513:Hepatitis B e Antigens; D020381:Interleukin-17