title: How to modulate the chemical structure of polyoxazolines by appropriate functionalization.
abstract: Polyoxazolines (POx) are increasingly being studied as polymeric building blocks due to the possibility of affording tunable properties. Additionally, as the biocompatibility and stealth behavior of POx are similar to that of poly(ethylene glycol) (PEG), it has become challenging to develop polyoxazoline-based (co)polymers. Even if POx have a lot of advantages, they also show an important drawback, as it has been impossible, to date, to prepare high-molecular-weight polyoxazolines with a low polydispersity index. Thus, it appears important that they be judiciously functionalized. This review covers the multiple ways that polyoxazolines can be functionalized. The use of functional initiators, functional terminating agents, and 2-R-2-oxazolines with an R functional side group is detailed. In conclusion, some perspectives on POx functionalizations are also reported, with functions permitting selective "click" reactions.
authors: Institut Charles Gerhardt Montpellier UMR5253, CNRS-UM2-ENSCM-UM1-Equipe Ingénierie et Architectures, Macromoléculaires, Université Montpellier II, Montpellier Cedex 5, France.
authors: Brieuc
authors: B
authors: Guillerm
authors: Sophie
authors: S
authors: Monge
authors: Vincent
authors: V
authors: Lapinte
authors: Jean-Jacques
authors: JJ
authors: Robin
mesh_terms: D001880:Boranes / Q000737:chemistry; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D010080:Oxazoles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D001880:Boranes; D010080:Oxazoles; C577913:poly(2-oxazoline); D011092:Polyethylene Glycols; C021274:boron trifluoride