title: [Is single-dose local anesthetic chondrotoxic?].
abstract: Intraarticular injection of local anesthetics is widely used in the pain management during and following arthroscopic surgery. In recent years, basic scientific studies have demonstrated local anesthetic chondrotoxicity in vivo and in vitro in both human and animal cartilage. There are some evidences suggesting a higher risk for chondrotoxicity with a longer exposure to a higher concentration of local anesthetics. The outcome of a single intraarticular injection of local anesthetics remains unclear and requires further investigation.
authors: Department of Orthopedics and Traumatology, Medicine Faculty of Gazi University, Ankara, Turkey. satikmd@gmail.com
authors: O Sahap
authors: OS
authors: Atik
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000187:drug effects*; D019902:Chondrocytes / Q000187:drug effects; D006801:Humans; D007270:Injections, Intra-Articular; D010149:Postoperative Pain / Q000517:prevention & control*
chemical_list: D000779:Anesthetics, Local