title: Hyalinizing clear cell carcinoma of the tonsil and its treatment.
abstract: Hyalinizing clear cell carcinoma (HCCC) is a rare neoplasm affecting mainly the minor salivary glands of the oral cavity. We describe an unusual case of HCCC involving the tonsil and its successful management. A 67-year-old Hispanic woman was discovered to have an asymptomatic right tonsillar mass on routine clinic visit that revealed HCCC on biopsy. A right radical tonsillectomy was performed and pathology confirmed HCCC with positive deep surgical margins. She declined the recommended adjuvant radiation therapy. A follow-up CT of the neck with contrast done a year later revealed a suspicious area of enhancement around the prior resection margin with regional cervical lymphadenopathy. Further workup, including biopsy, confirmed local recurrence. She was treated with definitive cisplatin-based chemoradiotherapy, achieving complete response. She remains without recurrence with more than 24 months of follow-up.
authors: Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0565, USA.
authors: Shadi B
authors: SB
authors: Hijjawi
authors: Shaad E
authors: SE
authors: Abdullah
authors: Kareem
authors: K
authors: Abdelhadi
authors: Eduardo
authors: E
authors: Eyzaguirre
authors: Maurice
authors: M
authors: Willis
authors: Nihal E
authors: NE
authors: Abdulla
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006818:Hyalin; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014067:Tonsillar Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin