title: Nanofibrillar cellulose films for controlled drug delivery.
abstract: Nanofibrillar cellulose (NFC) (also referred to as cellulose nanofibers, nanocellulose, microfibrillated, or nanofibrillated cellulose) has gotten recent and wide attention in various research areas. Here, we report the application of nanofibrillar cellulose as a matrix-former material for long-lasting (up to three months) sustained drug delivery. Film-like matrix systems with drug loadings between 20% and 40% were produced by a filtration method. This simple production method had an entrapment efficacy>90% and offers a possibility for the film thickness adjustment as well as applicability in the incorporation of heat sensitive compounds. The films had excellent mechanical properties suitable for easy handling and shape tailoring of the drug release systems. They were characterized in terms of the internal morphology, and the physical state of the encapsulated drug. The drug release was assessed by dissolution tests, and suitable mathematical models were used to explain the releasing kinetics. The drug release was sustained for a three month period with very close to zero-order kinetics. It is assumed that the nanofibrillar cellulose film sustains the drug release by forming a tight fiber network around the incorporated drug entities. The results indicate that the nanofibrillar cellulose is a highly promising new material for sustained release drug delivery applications.
authors: Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland. ruzica.kolakovic@helsinki.fi
authors: Ruzica
authors: R
authors: Kolakovic
authors: Leena
authors: L
authors: Peltonen
authors: Antti
authors: A
authors: Laukkanen
authors: Jouni
authors: J
authors: Hirvonen
authors: Timo
authors: T
authors: Laaksonen
mesh_terms: D002482:Cellulose / Q000008:administration & dosage* / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D057139:Nanofibers / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002482:Cellulose