title: Synthesis of vanadyl-hypocrellin A complex and its photodynamic properties research.
abstract: Hypocrellin A is an efficient photodynamic agent against many tumor cells and viruses. However, it was found that the preparation of injectable formula for HA was highly hampered by the poor water solubility of these compounds. So, here, a new water-soluble vanadyl-hypocrellin A complex was first synthesized and the complex forming process was studied using spectral and thermal dynamics methods. The results indicated that VO(2+)-HA can stable in aqueous solutions and exhibit increased photostability, affinity and photocleavage ability toward ctDNA under anaerobic condition. Moreover, in vitro studies illustrated that VO(2+)-HA also had strong anti-cancer activity.
authors: Analysis and Testing Center, Nanjing Normal University, Nanjing, PR China.
authors: Chao
authors: C
authors: Yang
authors: Fei
authors: F
authors: Ma
authors: Jing
authors: J
authors: Tang
authors: Lina
authors: L
authors: Han
authors: Shaohua
authors: S
authors: Wei
authors: Lin
authors: L
authors: Zhou
authors: Jiahong
authors: J
authors: Zhou
authors: Jian
authors: J
authors: Shen
authors: Fang
authors: F
authors: Wang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008027:Light; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D019800:Phenol; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D012995:Solubility; D014638:Vanadates / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D011809:Quinones; D014867:Water; D019800:Phenol; D014638:Vanadates; D010569:Perylene; C048388:hypocrellin A