title: Syzygium cumini seed extract protects the liver against lipid peroxidation with concurrent amelioration of hepatic enzymes and lipid profile of alcoholic rats.
abstract: The in vitro oxidative stress induced by ethanol/Fenton's reaction in rat liver homogenates decreased significantly in the presence of Syzygium cumini seed extract, suggesting the protective effect of the seed extract against the oxidative stress in liver. To corroborate the in vitro effects by an in vivo experiment, 24 rats were divided into four groups: control, S. cumini seed-extract-administered (SE), 15% ethanol-fed (Alc) and Alc+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 7 weeks significantly decreased the levels of liver LPO in the Alc+SE rats, suggesting that S. cumini seed not only obstructed the in vitro free radical production and subsequent oxidative stress, but also inhibited their in vivo formation. The oral administration of extract also reduced the enzyme activities of serum gammaglutamyl transferase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase and the levels of serum creatinine and blood urea nitrogen, serum/liver triglycerides and total cholesterol of the alcoholic rats. The levels of fecal cholesterol were increased by the extract. Fatty degenerations in liver and kidney were absent with S. cumini seed extract treatment. The results suggest that S. cumini seed may be a potential therapy for alcoholics and related dysfunctions by restraining oxidative stress.
authors: Department of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Bangladesh. shahdat@dhaka.net
authors: Shahdat
authors: S
authors: Hossain
authors: Imrul Hasan
authors: IH
authors: Chowdhury
authors: Mafroz Ahmed
authors: MA
authors: Basunia
authors: Taslima
authors: T
authors: Nahar
authors: Asiqur
authors: A
authors: Rahaman
authors: Bazlur Karim
authors: BK
authors: Choudhury
authors: Shahabuddin Kabir
authors: SK
authors: Choudhuri
authors: Ishtiaq
authors: I
authors: Mahmud
authors: Borhan
authors: B
authors: Uddin
mesh_terms: D000437:Alcoholism / Q000150:complications / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D005235:Fatty Liver, Alcoholic / Q000517:prevention & control*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012639:Seeds; D027842:Syzygium
chemical_list: D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D020011:Protective Agents