title: Interferon-β-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF.
abstract: IFN-β is induced via a c-fos dependent mechanism that is present downstream of the receptor activator of NF-κB ligand (RANKL)-RANK signal transduction cascade during osteoclast differentiation. Increased production of IFN-β in turn inhibits osteoclastogenesis. However, the mechanism by which IFN-β exerts its suppressive function remains unclear. In the present study, we found that miR-155, an IFN-β-induced miRNA, mediated the suppressive effect of IFN-β on osteoclast differentiation by targeting SOCS1 and MITF, two essential regulators of osteoclastogenesis. These findings have not only demonstrated that miR-155 inhibits osteoclast differentiation, but also provided a new therapeutic target for treatment of osteoclast-mediated diseases.
authors: Department of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, PR China.
authors: Jun
authors: J
authors: Zhang
authors: Hongying
authors: H
authors: Zhao
authors: Jinping
authors: J
authors: Chen
authors: Bing
authors: B
authors: Xia
authors: Yongming
authors: Y
authors: Jin
authors: Wei
authors: W
authors: Wei
authors: Jianjian
authors: J
authors: Shen
authors: Yazeng
authors: Y
authors: Huang
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D001862:Bone Resorption / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D002460:Cell Line; D015536:Down-Regulation; D057809:HEK293 Cells; D006801:Humans; D016899:Interferon-beta / Q000172:deficiency* / Q000235:genetics / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D051739:Microphthalmia-Associated Transcription Factor; C532623:Mirn155 microRNA, mouse; C497235:Mitf protein, mouse; D053245:RANK Ligand; D011994:Recombinant Proteins; C491590:Socs1 protein, mouse; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; C505689:Tnfsf11 protein, mouse; D016899:Interferon-beta