title: Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride.
abstract: Chitosan has become a focus of major interest in recent years due to its excellent biocompatibility, biodegradability and non-toxicity. Although this material has already been extensively investigated in the design of different types of drug delivery systems, it is still little explored for stomach specific drug delivery systems. The objective of the present investigation was to explore the potential of low molecular mass chitosan (LMCH) as carrier for a hydrodynamically balanced system (HBS) for sustained delivery of water soluble drug ciprofloxacin hydrochloride (CP). Various formulations were prepared by physical blending of drug and polymer(s) in varying ratios followed by encapsulation into hard gelatin capsules. All the formulations remained buoyant in 0.1 mol L⁻¹ HCl (pH 1.2) throughout the experiment. Effect of addition of xanthan gum (XG) or ethyl cellulose (EC) on drug release was also investigated. Zero order drug release was obtained from the formulations containing LMCH alone or in combination with XG, and in one instance also with EC. Our results suggest that LMCH alone or in combination with XG is an excellent material for stomach specific sustained delivery of CP from hydrodynamically balanced single unit capsules.
authors: Department of Pharmaceutics, College of Pharmacy, IFTM, Moradabad, India. anuragverma_iftm@yahoo.co.in
authors: Anurag
authors: A
authors: Verma
authors: Ashok K
authors: AK
authors: Bansal
authors: Amitava
authors: A
authors: Ghosh
authors: Jayanta K
authors: JK
authors: Pandit
mesh_terms: D002152:Calorimetry, Differential Scanning; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D055598:Chemical Phenomena; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry / Q000378:metabolism; D005240:Feasibility Studies; D005744:Gastric Acid / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D057446:Hydrodynamics; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008970:Molecular Weight; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D011135:Polysaccharides, Bacterial; D002939:Ciprofloxacin; C013517:ethyl cellulose; D005780:Gelatin; D002482:Cellulose; D048271:Chitosan; C002563:xanthan gum