title: [Isotretinoin embryopathy with microtia-anotia and congenital heart disease: case report].
abstract: Isotretinoin is a retinoid that derivates from vitamin A. It is indicated for recalcitrant nodular acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart and nervous system malformations have been described associated to prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including facial paralysis, right anotia, left microtia and complex heart disease. Key words: isotretinoin, congenital abnormalities, teratology.
authors: Departamento de Ciencias Básicas Médicas, Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia. hmpachajoa@icesi.edu.co
authors: Harry
authors: H
authors: Pachajoa
authors: Adriana
authors: A
authors: Ordoñez
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000013:Congenital Abnormalities / Q000209:etiology*; D065817:Congenital Microtia; D004423:Ear / Q000002:abnormalities; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin / Q000009:adverse effects*
chemical_list: D015474:Isotretinoin