title: Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy.
abstract: The aim of this study was to determine the levels of proinflammatory tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) cytokines in whole unstimulated saliva in subjects with burning mouth syndrome (BMS) before and after treatment with low-level laser therapy (LLLT). BMS is characterized by a continuous, painful burning sensation in a clinically normal-appearing oral mucosa. A sample consisting of 40 consecutive subjects was selected on a voluntary basis from the pool of patients who presented for diagnosis and treatment of BMS at the Oral Medicine Unit of the Faculty of Medicine of the University of Rijeka. For determination of salivary levels of TNF-α and IL-6, ELISA (Sigma Immunochemicals, St. Louis, MO, USA) was performed to determine the salivary levels of TNF-α and IL-6. After 4 weeks of LLLT, the salivary levels of TNF-α and IL-6 in the experimental group decreased significantly (p < 0.001). There was no significant difference in the experimental group regarding visual analogue scale.
authors: Department of Oral Medicine and Periodontology, School of Dentistry, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka, Croatia. sonja.pezelj-ribaric@medri.hr
authors: Sonja
authors: S
authors: Pezelj-Ribarić
authors: Lumnije
authors: L
authors: Kqiku
authors: Gordana
authors: G
authors: Brumini
authors: Miranda Muhvić
authors: MM
authors: Urek
authors: Robert
authors: R
authors: Antonić
authors: Davor
authors: D
authors: Kuiš
authors: Irena
authors: I
authors: Glažar
authors: Peter
authors: P
authors: Städtler
mesh_terms: D000704:Analysis of Variance; D002054:Burning Mouth Syndrome / Q000378:metabolism* / Q000532:radiotherapy*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012463:Saliva / Q000737:chemistry*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha