title: A mucormycosis case in a cirrhotic patient successfully treated with posaconazole and review of published literature.
abstract: Mucormycosis is an invasive fungal infection associated with a high mortality rate, especially in immunocompromised hosts. Mucormycosis rarely occurs in cirrhotic patients. Here, we report a case of mucormycosis with underlying liver cirrhosis and diabetes mellitus. The patient suffered from maxillary sinusitis and osteomyelitis, and the infection was successfully treated with antifungal agents, surgical debridement, and hyperbaric oxygen therapy. The antifungal treatments used were liposomal amphotericin B, itraconazole, and posaconazole. Although our patient had liver cirrhosis (Child-Pugh classification B), no hepatic decompensation was developed during the treatment course of posaconazole. This is the first report of the safe and effective use of posaconazole for the treatment of mucormycosis in a cirrhotic patient.
authors: Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: Shang-Yi
authors: SY
authors: Lin
authors: Po-Liang
authors: PL
authors: Lu
authors: Kun-Bow
authors: KB
authors: Tsai
authors: Chun-Yu
authors: CY
authors: Lin
authors: Wei-Ru
authors: WR
authors: Lin
authors: Tun-Chieh
authors: TC
authors: Chen
authors: Ya-Ting
authors: YT
authors: Chang
authors: Chung-Hao
authors: CH
authors: Huang
authors: Chi-Yu
authors: CY
authors: Chen
authors: Chung-Chih
authors: CC
authors: Lai
authors: Yen-Hsu
authors: YH
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009090:Mucorales / Q000302:isolation & purification* / Q000502:physiology; D009091:Mucormycosis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole