title: Personal exposure to specific volatile organic compounds and acute changes in lung function and heart rate variability among urban cyclists.
abstract: BACKGROUND
  Few studies have examined the acute cardiorespiratory effects of specific volatile organic compound (VOC) exposures from traffic pollution.
  
  
  METHODS
  A cross-over study was conducted among 42 healthy adults during summer 2010 in Ottawa, Canada. Participants cycled for 1-h along high and low-traffic routes and VOC exposures were determined along each route. Lung function, exhaled nitric oxide, and heart rate variability were monitored before cycling and 1-4h after the start of cycling. Bayesian hierarchical models were used to examine the relationship between 26 VOCs and acute changes in clinical outcomes adjusted for potential confounding factors.
  
  
  RESULTS
  Each inter-quartile range (IQR) increase in propane/butane exposure was associated with a 2.0 millisecond (ms) (95% CI: 0.65, 3.2) increase in SDNN (standard deviation of normal-to-normal intervals), a 24 ms(2) (95% CI: 6.6, 41) increase in HF (high frequency power), and a 65 ms(2) (95% CI: 11, 118) increase in LF (low frequency power) in the hours following cycling. IQR increases in ethane and isoprene were associated with a 5.8 ms (95% CI: -9.8, -1.7): decrease in SDNN and a 24 ms(2) (95% CI: -44, -7.9) decrease in HF, respectively. IQR increases in benzene exposure were associated with a 1.7 ppb (95% CI: 1.1, 2.3) increase in exhaled nitric oxide and each IQR increase in 3-methylhexane exposure was associated with a 102 mL (95% CI: -157, -47) decrease in forced expiratory volume in 1-s.
  
  
  CONCLUSIONS
  Exposure to traffic-related VOCs may contribute to acute changes in lung function, inflammation, or heart rate variability.
authors: Health Canada, Air Health Sciences Division, Ottawa, ON, Canada. scott.weichenthal@hc-sc.gc.ca
authors: Scott
authors: S
authors: Weichenthal
authors: Ryan
authors: R
authors: Kulka
authors: Patrick
authors: P
authors: Bélisle
authors: Lawrence
authors: L
authors: Joseph
authors: Aimee
authors: A
authors: Dubeau
authors: Christina
authors: C
authors: Martin
authors: Daniel
authors: D
authors: Wang
authors: Robert
authors: R
authors: Dales
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D001499:Bayes Theorem; D001642:Bicycling; D004781:Environmental Exposure; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D014505:Urban Population; D055549:Volatile Organic Compounds / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D055549:Volatile Organic Compounds