title: Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman.
abstract: Rosuvastatin (Crestor, AstraZeneca) is a commonly used drug for managing hypercholesterolaemia. It is a very safe medication with mostly acceptable side effects. Rare but serious side effects are not well known. A 64-year-old woman presented with bloody diarrhoea after starting rosuvastatin for hypercholesterolaemia. Stool microscopy and culture ruled out infective causes. Abdominal CT scan revealed normal calibre celiac axis and superior mesenteric artery. Colonoscopic biopsy revealed ischaemic colitis as the final histological diagnosis. The patient is in complete remission after ceasing the medication. Rosuvastatin causing ischaemic colitis should be considered a rare but serious adverse drug reaction.
authors: General Sugery Department, Mackay Base Hospital, Mackay, Australia. jackie.tan@uqconnect.edu.au
authors: Jackie
authors: J
authors: Tan
authors: Casper Francois
authors: CF
authors: Pretorius
authors: Paul Vincent
authors: PV
authors: Flanagan
authors: Antonio
authors: A
authors: Pais
mesh_terms: D017091:Colitis, Ischemic / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005464:Fluorobenzenes / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D006937:Hypercholesterolemia / Q000188:drug therapy; D008875:Middle Aged; D011743:Pyrimidines / Q000009:adverse effects*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000009:adverse effects*; D028761:Withholding Treatment
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium