title: Lovastatin protects mithochondrial and renal function in kidney ischemia-reperfusion in rats.
abstract: OBJECTIVE
  To investigate the effect of lovastatin on renal ischemia followed by reperfusion.
  
  
  METHODS
  Thirty one Wistar rats submitted to left renal ischemia for 60 minutes followed by contralateral nephrectomy were divided into two groups: A (n =17, control, no treatment), and B (n=14, lovastatin 15 mg/kg/day p.o. ten days before ischemia). The animals were sacrificed at the end of ischemia, after 24 hours and at seven days after reperfusion. Survival, serum urea and creatinine levels and renal mitochondrial function were evaluated.
  
  
  RESULTS
  Mortality was 29.4% in group A and 0.7% in group B. Urea and creatinine levels were increased in both groups, but the values were significantly lower in group B. Mitochondrial function showed decoupling in 83.4% of group A, as opposed to 38.4/% of group B.
  
  
  CONCLUSIONS
  The result shows a protective action of renal function by lovastatin administered before ischemia/reperfusion. Since most of the mitochondrial fraction presented membranes with the ability to maintain ATP production in group B, stabilization of the mitochondrial membrane should be considered as part of the protective action of lovastatin on renal function in ischemia/reperfusion.
authors: Division of Urology, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. silvio.tucci@sbu.org.br
authors: Silvio
authors: S
authors: Tucci Junior
authors: Carlos Augusto Fernandes
authors: CA
authors: Molina
authors: Marcelo Ferreira
authors: MF
authors: Cassini
authors: Daniel Mendes
authors: DM
authors: Leal
authors: Cássio Antonio Botene
authors: CA
authors: Schineider
authors: Antonio Carlos Pereira
authors: AC
authors: Martins
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D008148:Lovastatin / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D014508:Urea; D008148:Lovastatin; D003404:Creatinine