title: Orexins cause epileptic activity.
abstract: Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.
authors: Balikesir State Hospital, Balikesir, Turkey. haerken@yahoo.com
authors: Haydar Ali
authors: HA
authors: Erken
authors: Gülten
authors: G
authors: Erken
authors: Osman
authors: O
authors: Genç
authors: Selim
authors: S
authors: Kortunay
authors: Melike
authors: M
authors: Sahiner
authors: Günfer
authors: G
authors: Turgut
authors: Sebahat
authors: S
authors: Turgut
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D007276:Injections, Intraventricular; D047908:Intracellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000009:adverse effects*; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000068797:Orexins; D051381:Rats; D017208:Rats, Wistar
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins