title: Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection.
abstract: Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging-related brain disorders. This review is focused on the new developments in oxidative stress-induced neurodegeneration. Further, based on our own investigations, new roles of quercetin, an antioxidant compound in hypoxia and ischemia induced neuroprotection in relation to suppression of oxidative stress, improvement in behavioral function, reduction in infarct volume, brain swelling, and cellular injury in both in vivo and in vitro models are discussed. Our new findings clearly suggest that antioxidant compounds have potential role in therapeutic strategies to treat neurodegenerative diseases in clinical settings.
authors: School of Biomedical Engineering, Institute of Technology, Banaras Hindu University, Varanasi, India.
authors: Anand Kumar
authors: AK
authors: Pandey
authors: Ranjana
authors: R
authors: Patnaik
authors: Dafin F
authors: DF
authors: Muresanu
authors: Aruna
authors: A
authors: Sharma
authors: Hari Shanker
authors: HS
authors: Sharma
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005609:Free Radicals / Q000378:metabolism; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D011794:Quercetin / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D011794:Quercetin