title: Sjögren's syndrome at the crossroad of polyautoimmunity.
abstract: The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases.
authors: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 # 63-C-69, Bogota, Colombia.
authors: Manuel J
authors: MJ
authors: Amador-Patarroyo
authors: Juan Guillermo
authors: JG
authors: Arbelaez
authors: Ruben D
authors: RD
authors: Mantilla
authors: Alberto
authors: A
authors: Rodriguez-Rodriguez
authors: Jorge
authors: J
authors: Cárdenas-Roldán
authors: Ricardo
authors: R
authors: Pineda-Tamayo
authors: Mayra R
authors: MR
authors: Guarin
authors: Liliana Lopez
authors: LL
authors: Kleine
authors: Adriana
authors: A
authors: Rojas-Villarraga
authors: Juan-Manuel
authors: JM
authors: Anaya
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000150:complications / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D012907:Smoking / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000150:complications / Q000276:immunology*
chemical_list: D001323:Autoantibodies