title: [Role of thrombolysis in massive pulmonary embolism].
abstract: OBJECTIVE
  Massive pulmonary embolism is a life threatening pathology with a high mortality over 20%. Thrombolysis is one of therapy ways that leads to a lower rate of death. The aim of the study is to show interest, limits and complications of thrombolytic therapy in massive pulmonary embolism.
  
  
  METHODS
  This descriptive study presents 8 cases of pulmonary embolism admitted to the Cardiology Division of Grand-Yoff from March 2003 to March 2006. All cases confirmed by Tomodensitometry (TDM) with massive pulmonary embolism were included in this study.
  
  
  RESULTS
  We used thrombolytic only in 8 cases of massive pulmonary embolism about 32. In-hospital prevalence was 25%. The average age was 49.8 ± 19.1 (from 15 to 72) and sex-ratio 0.33. Seven patients had a moderate clinical probability Well's score and one of them 1 had a high clinical probability. The clinical signs were: cardio-vascular collapse (7 cases), syncope (1) and cardio-vascular arrest. The electrocardiogram showed a sub-epicardial ischemia (4 cases), a right bundle branch block and a Mac Ginn White's sign. Two patients had a right-basal opacification at the chest X ray. The echocardiography found 5 cases of right ventricular dilatation, 1 case of paradoxal septum, 1 case of multiple thrombi in the right ventricule. The TDM confirmed diagnosis with 3 cases of bilateral pulmonary embolism, 1 case of pulmonary aneurysm. The treatment used thrombolytic : 1,500,000 IU of streptokinase, sympathomimetic drugs, anticoagulation with heparins and vitamin K antagonists.
authors: Docteur Mouhamadou Bamba Ndiaye Service de Cardiologie, Hopital Aristide Le DANTEC, Dakar, Senegal. bambandiaye75 yahoo.fr
authors: M B
authors: MB
authors: Ndiaye
authors: M
authors: M
authors: Diao
authors: A D
authors: AD
authors: Kane
authors: A
authors: A
authors: Mbaye
authors: A
authors: A
authors: Mohamed
authors: N V
authors: NV
authors: Yameogo
authors: M
authors: M
authors: Bodian
authors: M M
authors: MM
authors: Dia
authors: I B
authors: IB
authors: Diop
authors: M
authors: M
authors: Sarr
authors: A
authors: A
authors: Kane
authors: S A
authors: SA
authors: Ba
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D014812:Vitamin K