title: A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection.
abstract: Based on Ru(bpy)(3)(2+)-Au nanoparticles decorated multi-walled carbon nanotubes composites and a molecularly imprinted polymer (MIP), we propose a novel molecularly imprinted electrochemiluminescence (ECL) sensor to selectively determine isoniazid (INH). The MIP is synthesized through electrochemical copolymerization of acrylamide and N,N'-methylene diacrylamide in the presence of INH template molecules. The enhanced ECL intensity is linear in the range of 0.1 to 110 μg cm(-3) and the detection limit is 0.08 μg cm(-3) (3σ) INH with relative standard deviation 3.8% (n = 6) for 8 μg cm(-3). As a result, the sensor has been successfully applied to the determination of INH in human urine and pharmaceutical samples. Moreover, the possible ECL mechanism is discussed.
authors: Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
authors: Bowan
authors: B
authors: Wu
authors: Zhihua
authors: Z
authors: Wang
authors: Zhonghua
authors: Z
authors: Xue
authors: Xibin
authors: X
authors: Zhou
authors: Jie
authors: J
authors: Du
authors: Xiuhui
authors: X
authors: Liu
authors: Xiaoquan
authors: X
authors: Lu
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007538:Isoniazid / Q000032:analysis* / Q000737:chemistry; D008163:Luminescent Measurements / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry
chemical_list: D000178:Acrylamides; D037742:Nanotubes, Carbon; D009942:Organometallic Compounds; C415768:tris(2,2'-bipyridyl)ruthenium(II); D006046:Gold; D007538:Isoniazid