title: A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs.
abstract: The authors evaluated dermal phototoxicity using the world smallest minipig (MMPig: Microminipig). MMPigs were administered 100 mg/kg ciprofloxacin hydrochloride with an infusion pump. The dorsal area of each animal was irradiated with ultraviolet-A irradiation. The left dorsal skin was irradiated at intensities of 5, 10, 15, and 20 J/cm(2), and the right dorsal back skin was set as a nonirradiated site. Gross and histopathological examinations were conducted before irradiation and from 1 to 72 hr after irradiation. Initial changes in the skin were necrosis of the basal and/or prickle cell layer and cellular infiltration from 24 hr after irradiation. Vesicle formation observed from 48 hr after irradiation was considered similar to bullous eruptions, a known side effect of fluoroquinolones in humans. Therefore, the authors suggest that the MMPig may be a useful experimental animal model for dermal phototoxicity studies.
authors: 1Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima, Japan.
authors: Tsuyoshi
authors: T
authors: Yoshikawa
authors: Yoshihiro
authors: Y
authors: Takahashi
authors: Hiroaki
authors: H
authors: Kawaguchi
authors: Shinji
authors: S
authors: Utsunomiya
authors: Naoki
authors: N
authors: Miura
authors: Hiroyuki
authors: H
authors: Izumi
authors: Noriaki
authors: N
authors: Miyoshi
authors: Akihide
authors: A
authors: Tanimoto
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000633:toxicity*; D017484:Dermatitis, Phototoxic; D004195:Disease Models, Animal; D005260:Female; D007262:Infusions, Intravenous; D010787:Photosensitivity Disorders; D012867:Skin / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D012871:Skin Diseases / Q000139:chemically induced / Q000209:etiology*; D013552:Swine; D013556:Swine, Miniature; D018675:Toxicity Tests / Q000379:methods*; D014466:Ultraviolet Rays
chemical_list: D002939:Ciprofloxacin