title: [Characteristics of stable chronic obstructive pulmonary disease related to systemic inflammation].
abstract: OBJECTIVE
  Chronic obstructive pulmonary disease (COPD) is characterized by a systemic inflammation. The aim of this study was to evaluate the association between systemic inflammation, measured with C reactive protein (CRP), and clinical and functional outcomes of the disease.
  
  
  METHODS
  A randomized sample of 413 COPD patients from 31 primary health care centers of Barcelona was evaluated. Medical history, anthropometric measurements, toxic habits, treatments, Chronic Respiratory Questionnaire (CRQ) and dyspnea were registered. Spirometry, exhaled CO concentration and CRP in capillary blood were performed.
  
  
  RESULTS
  Median (standard deviation) of the age was 72 (8.4) years and forced expiratory volume in one second (FEV(1)) postbronchodilatador 1.65 (0.65) l. The correlation was negative between CRP and FEV(1) postbronchodilatador(r=-0.25, P<0.001) and between CRP and CRQ scores (r=-0.098, P=0.048) and positive between CRP and CO (r=0.1, P=0.039). The ratio of patients with elevated CRP was higher in advanced GOLD stage (P<0.001), worst dyspnea (P=0.042), patients treated with inhaled corticosteroids (P=0.018) and if they had been hospitalized during the last year (P=0.026). The multivariant analysis showed, as independent factors of elevated CRP, FEV(1) postbronchodilator and CO concentration.
  
  
  CONCLUSIONS
  In COPD patients, active smoking habit and the airway's obstruction degree are associated with a greater intensity of the inflammatory systemic response measured by the CRP.
authors: Departamento de Neumología, Instituto de Investigación Biomédica (IIB Sant Pau), Universidad Autónoma de Barcelona, Barcelona, España. isolanes@santpau.cat
authors: Ingrid
authors: I
authors: Solanes
authors: Ignasi
authors: I
authors: Bolíbar
authors: Maria Antònia
authors: MA
authors: Llauger
authors: Casimira
authors: C
authors: Medrano
authors: Meritxell
authors: M
authors: Peiró
authors: Mar
authors: M
authors: Fraga
authors: Maria Antònia
authors: MA
authors: Pou
authors: Jordi
authors: J
authors: Giner
authors: Montserrat
authors: M
authors: Freixas
authors: Vicente
authors: V
authors: Plaza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein