title: Nortriterpene glycosides of the sarasinoside class from the sponge Lipastrotethya sp.
abstract: Five new nortriterpene glycosides, along with eight known compounds of the sarasinoside class, were isolated from the tropical sponge Lipastrotethya sp. collected from Chuuk, Micronesia. The structures of these new compounds, designated as sarasinosides N-R (9-13), were determined by combined spectroscopic and chemical methods. The aglycone portions of 10-13 were found to be unprecedented among nortriterpeneoids on the basis of extensive NMR analyses. Several of these compounds exhibited cytotoxicity against A549 and K562 cell lines as well as weak inhibitory activity against Na(+)/K(+)-ATPase.
authors: Natural Products Research Institute, College of Pharmacy,  Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors: Jung-Ho
authors: JH
authors: Lee
authors: Ju-eun
authors: JE
authors: Jeon
authors: Yeon-Ju
authors: YJ
authors: Lee
authors: Hyi-Seung
authors: HS
authors: Lee
authors: Chung J
authors: CJ
authors: Sim
authors: Ki-Bong
authors: KB
authors: Oh
authors: Jongheon
authors: J
authors: Shin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes