title: Myelin basic protein synthesis is regulated by small non-coding RNA 715.
abstract: Oligodendroglial Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. During oligodendrocyte differentiation, MBP mRNA is kept in a translationally silenced state while intracellularly transported, until neuron-derived signals initiate localized MBP translation. Here we identify the small non-coding RNA 715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes to cytoplasmic granular structures and associates with MBP mRNA transport granule components. We also detect increased levels of sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein.
authors: Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128 Mainz, Germany.
authors: Nina M
authors: NM
authors: Bauer
authors: Christina
authors: C
authors: Moos
authors: Jack
authors: J
authors: van Horssen
authors: Maarten
authors: M
authors: Witte
authors: Paul
authors: P
authors: van der Valk
authors: Benjamin
authors: B
authors: Altenhein
authors: Heiko J
authors: HJ
authors: Luhmann
authors: Robin
authors: R
authors: White
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D003594:Cytoplasmic Granules / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology; D004676:Myelin Basic Protein / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D058727:RNA, Small Untranslated / Q000378:metabolism*; D051381:Rats
chemical_list: D004676:Myelin Basic Protein; D012333:RNA, Messenger; D058727:RNA, Small Untranslated