title: Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1.
abstract: RNA chaperones are proteins able to rearrange nucleic acid structures towards their most stable conformations. In retroviruses, the reverse transcription of the viral RNA requires multiple and complex nucleic acid rearrangements that need to be chaperoned. HIV-1 has evolved different viral-encoded proteins with chaperone activity, notably Tat and the well described nucleocapsid protein NCp7. We propose here an overview of the recent reports that examine and compare the nucleic acid chaperone properties of Tat and NCp7 during reverse transcription to illustrate the variety of mechanisms of action of the nucleic acid chaperone proteins.
authors: Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, UMR 7213 CNRS, Université de Strasbourg, 67401 Illkirch, France.
authors: Julien
authors: J
authors: Godet
authors: Christian
authors: C
authors: Boudier
authors: Nicolas
authors: N
authors: Humbert
authors: Roland
authors: R
authors: Ivanyi-Nagy
authors: Jean-Luc
authors: JL
authors: Darlix
authors: Yves
authors: Y
authors: Mély
mesh_terms: D015497:HIV-1 / Q000502:physiology*; D018832:Molecular Chaperones / Q000378:metabolism*; D012357:RNA, Transfer, Lys / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D048348:Reverse Transcription; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*; D054322:tat Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D018832:Molecular Chaperones; C071884:NCP7 protein, Human immunodeficiency virus 1; D012357:RNA, Transfer, Lys; D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus