title: Synthesis of multifunctional Ag@Au@phenol formaldehyde resin particles loaded with folic acids for photothermal therapy.
abstract: Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR core-shell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light.
authors: Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors: Ping
authors: P
authors: Yang
authors: Qi-Zhi
authors: QZ
authors: Xu
authors: Sheng-Yu
authors: SY
authors: Jin
authors: Yang
authors: Y
authors: Lu
authors: Yang
authors: Y
authors: Zhao
authors: Shu-Hong
authors: SH
authors: Yu
mesh_terms: D005492:Folic Acid / Q000737:chemistry*; D005557:Formaldehyde / Q000138:chemical synthesis* / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D019800:Phenol / Q000138:chemical synthesis* / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry*; D010783:Photometry; D010789:Phototherapy; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000627:therapeutic use*; D019265:Spectroscopy, Near-Infrared; D013388:Succinimides / Q000737:chemistry
chemical_list: D010636:Phenols; D011108:Polymers; D013388:Succinimides; D005557:Formaldehyde; D019800:Phenol; D012834:Silver; C011529:phenol-formaldehyde resin; D005492:Folic Acid; C001426:N-hydroxysuccinimide