title: The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters.
abstract: The ABC proteins are a family of membrane transporters that mediates the extrusion from cells of a wide variety of structurally unrelated substrates. The current review focuses on the role of these efflux pumps located in the intestine on the low oral bioavailability of trans-resveratrol. The enterocytes hold in the apical membrane three transporters, namely, P-glycoprotein (P-gp), multidrug resistance associated protein 2 (MRP2) and breast cancer resistance protein (BCRP), whereas the basolateral membrane contains multidrug resistance associated protein 3 (MRP3). The use of different specific inhibitors of these transporters as well as knockout mice enabled us to conclude that MRP2 and BCRP are involved in the extrusion of trans-resveratrol glucuronide and sulfate to the intestinal lumen without the participation of P-gp. The role of these transporters as a bottleneck in the absorption of trans-resveratrol cannot be undervalued affecting not only the bioavailability of its glucuronide and sulfate but also their distribution in the different organs.
authors: Departament de Fisiologia and Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB), Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain. jmplanas@ub.edu
authors: Joana M
authors: JM
authors: Planas
authors: Irene
authors: I
authors: Alfaras
authors: Helena
authors: H
authors: Colom
authors: M Emília
authors: ME
authors: Juan
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001682:Biological Availability; D006801:Humans; D007408:Intestinal Absorption; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D018528:ATP-Binding Cassette Transporters; D013267:Stilbenes; D000077185:Resveratrol