title: Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis.
abstract: OBJECTIVE
  to assess the ability of curcuminoid from Curcuma domestica Val in reducing the cycloxygenase-2 secretion by synovial fluid's monocytes compared to diclofenac sodium in patients with osteoarthritis.
  
  
  METHODS
  this was a prospective randomized open end blinded evaluation (PROBE) study. The subjects were patients with knee osteoarthritis who were divided randomly into two groups, the first group received 30 mg 3 times daily of curcuminoid and the second group received 25 mg 3 times daily of diclofenac sodium. The joints aspiration was done and the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes was evaluated by scoring method before and after 4 weeks of treatments.
  
  
  RESULTS
  a total of 80 patients with knee osteoarthritis were enrolled. In curcuminoid group the average scores were 1.84±0.37 and 1.15±0.28 respectively (p<0.001). In diclofenac group the average scores were 1.79±0.38 and 1.12±0.27 respectively (p<0.001). In curcuminoid group the decreasing score of cycloxygenase-2 secretion was 0.70±0.51 while in diclofenac group was 0.67±0.45. There was no significant difference in decreasing the score of cycloxygenase enzyme secretion between both treatment groups (p=0.89).
  
  
  CONCLUSIONS
  the ability of curcuminoid from Curcuma domestica Val. rhizome extract was not significantly different compared to diclofenac sodium in suppressing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes.
authors: Department of Internal Medicine, Faculty of Medicine, Gadjah Mada University - dr. Sardjito Hospital. Jl. Kesehatan no. 1, Yogyakarta, Indonesia. kertianyoman@yahoo.com
authors: Nyoman
authors: N
authors: Kertia
authors: Ahmad H
authors: AH
authors: Asdie
authors: Wasilah
authors: W
authors: Rochmah
authors: Marsetyawan
mesh_terms: D000368:Aged; D030024:Curcuma; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004008:Diclofenac / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology; D020370:Osteoarthritis, Knee / Q000188:drug therapy / Q000201:enzymology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome; D016037:Single-Blind Method; D013582:Synovial Fluid / Q000187:drug effects / Q000201:enzymology
chemical_list: D016861:Cyclooxygenase Inhibitors; D010936:Plant Extracts; D004008:Diclofenac; D051546:Cyclooxygenase 2