title: The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.
abstract: We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.
authors: CEA, Institut de Biologie et Technologies de Saclay, Gif-sur-Yvette, France.
authors: Pascal
authors: P
authors: Belin
authors: Mireille
authors: M
authors: Moutiez
authors: Sylvie
authors: S
authors: Lautru
authors: Jérôme
authors: J
authors: Seguin
authors: Jean-Luc
authors: JL
authors: Pernodet
authors: Muriel
authors: M
authors: Gondry
mesh_terms: D000595:Amino Acid Sequence; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D054659:Diketopiperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010453:Peptide Synthases / Q000378:metabolism*; D011487:Protein Conformation; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*
chemical_list: D001688:Biological Products; D054659:Diketopiperazines; D012346:RNA, Transfer, Amino Acyl; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase