title: An interesting collection of paraneoplastic syndromes in a patient with a malignant thymoma.
abstract: Paraneoplastic neurological syndromes are conditions that manifest as the remote effects of cancer. These are very rare, occurring in 1/10000 patients with a malignancy, and include Lambert-Eaton myasthenic syndrome, limbic encephalitis, subacute cerebellar ataxia, opsoclonus-myoclonus, Stiff-Person Syndrome, retinopathies, chronic gastrointestinal pseudo-obstruction and sensory neuropathy. This report describes a case of 41-year-old man who presented with elements of multiple paraneoplastic syndromes, including chronic gastrointestinal pseudo-obstruction, myasthenia gravis-Lambert-Eaton overlap syndrome and polymyositis, and who was subsequently found to have a malignant thymoma. There are only three reported cases in the literature describing cases of Lambert-Eaton myasthenic syndrome in association with a thymoma, and only one case of a myasthenia gravis-Lambert-Eaton overlap syndrome in a patient with thymoma. However, there are no documented cases in the literature of this constellation of syndromes in a patient with a malignant thymoma.
authors: Department of Surgery and Cancer, Imperial College London, London, UK.
authors: Emaddin S
authors: ES
authors: Kidher
authors: Natalia
authors: N
authors: Briceno
authors: Ali
authors: A
authors: Taghi
authors: Andrew
authors: A
authors: Chukwuemeka
mesh_terms: D000328:Adult; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology*; D015624:Lambert-Eaton Myasthenic Syndrome / Q000209:etiology*; D008297:Male; D009157:Myasthenia Gravis / Q000209:etiology*; D017285:Polymyositis / Q000209:etiology*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery