title: Combined PET/CT-perfusion in patients with head and neck cancers.
abstract: OBJECTIVE
  Computed tomography perfusion (CTP) can provide information about angiogenesis and blood-flow characteristics in tumours. [18F]Fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) is one of the major oncological imaging techniques which provides information about viability of the tumour cell and partly also about its aggressiveness. The aim of the study was to investigate the relationship between FDG and CTP data in patients with head and neck cancers.
  
  
  METHODS
  Forty-one patients with a clinically suspected head and neck cancer were prospectively included. All patients underwent a combined PET/CT with an integrated CTP examination in the area of the head and neck tumour. CTP data (BF, BV and MTT) and PET data (SUVmax, SUVmean, TLG, PETvol) were compared between tumours and (1) healthy contralateral tissue, (2) inflammatory lesions, (3) metastatic lymph nodes, and CTP data and PET data were correlated in tumours.
  
  
  RESULTS
  Thirty-five patients had a head and neck cancer. All CTP data were statistically different between tumours, inflammatory lesions, healthy tissue and metastatic lymph nodes; PET/CT data were in part significantly different. CTP and PET parameters were not significantly correlated.
  
  
  CONCLUSIONS
  CTP and PET parameters were not significantly correlated; thus, the additional CTP values provide additional insights into tumour behaviour and their glycolytic status.
authors: Department of Radiology, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland. patrick.veit-haibach@usz.ch
authors: Patrick
authors: P
authors: Veit-Haibach
authors: Daniel
authors: D
authors: Schmid
authors: Klaus
authors: K
authors: Strobel
authors: Jan D
authors: JD
authors: Soyka
authors: Niklaus G
authors: NG
authors: Schaefer
authors: Stephan K
authors: SK
authors: Haerle
authors: Gerhard
authors: G
authors: Huber
authors: Gabriele
authors: G
authors: Studer
authors: Burkhardt
authors: B
authors: Seifert
authors: Thomas F
authors: TF
authors: Hany
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003287:Contrast Media; D003974:Diatrizoate Meglumine; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D003974:Diatrizoate Meglumine; D007472:Iohexol; C038192:iopromide