title: Synthesis of 5-methyl-1,3-oxathiolane-based nucleoside analogues as potential antiviral agents.
abstract: A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.
authors: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Modena, Italy.
authors: Silvia
authors: S
authors: Franchini
authors: Annalisa
authors: A
authors: Tait
authors: Claudia
authors: C
authors: Sorbi
authors: Livio
authors: L
authors: Brasili
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000633:toxicity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D013876:Thiophenes