title: Salivary basic fibroblast growth factor in patients with oral squamous cell carcinoma or oral lichen planus.
abstract: OBJECTIVE
  The objective of this study was to gather preliminary data concerning the feasibility of using salivary basic fibroblast growth factor (bFGF) for detecting development of oral squamous cell carcinoma (OSCC) in patients with oral lichen planus (OLP), and in patients with OSCC whose disease was in remission.
  
  
  METHODS
  Saliva samples were collected from 5 patient groups: patients with newly diagnosed OSCC, patients with OSCC whose disease was in remission, patients with OLP in disease-active state, patients with OLP in disease-inactive state, and healthy controls. Salivary bFGF levels were determined by enzyme-linked immunosorbent assay, and data were analyzed using the Mann-Whitney U test.
  
  
  RESULTS
  Salivary bFGF levels were significantly elevated in patients with newly diagnosed OSCC compared with patients with OSCC in remission, patients with disease-active OLP, and healthy controls. No significant difference was found between patients with newly diagnosed OSCC and patients with disease-inactive OLP.
  
  
  CONCLUSIONS
  Our results suggested that salivary bFGF might be a potential biomarker for detecting OSCC development in patients with OSCC in remission, but not in patients with OLP.
authors: Department of Biomedical Sciences, Texas A&M Health Science Center-Baylor College of Dentistry, Dallas, Texas 75246, USA.
authors: Lakshmi Mitreyi
authors: LM
authors: Gorugantula
authors: Terry
authors: T
authors: Rees
authors: Jacqueline
authors: J
authors: Plemons
authors: Huey-Shys
authors: HS
authors: Chen
authors: Yi-Shing Lisa
authors: YS
authors: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism*; D016022:Case-Control Studies; D005240:Feasibility Studies; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D006801:Humans; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000378:metabolism; D009365:Neoplasm Regression, Spontaneous; D012463:Saliva / Q000737:chemistry*; D018401:Sample Size; D018709:Statistics, Nonparametric
chemical_list: D016222:Fibroblast Growth Factor 2