title: LN-5 antibody against human macrophages cross-reacts with routinely processed human sebaceous glands.
abstract: LN-5 monoclonal antibody against human macrophages was found to selectively stain human sebaceous glands in formalin-fixed, paraffin-embedded skin samples. Undifferentiated sebocyte progenitors were negative, and only sebocytes from the onset of their differentiation revealed positive cytoplasmic immunofluorescence. Since there are very few selective and easy-to-use markers of sebaceous glands, LN-5 antibody can offer a simple and relatively specific way to detect human sebocytes from the onset of their differentiation in routinely processed material, both freshly prepared and archival.
authors: Department of Histology Jagiellonian University Medical College, Krakow, Poland. mmlis@cyf-kr.edu.pl
authors: Grzegorz J
authors: GJ
authors: Lis
authors: Jan A
authors: JA
authors: Litwin
authors: Alicja
authors: A
authors: Furgał-Borzych
authors: Grażyna
authors: G
authors: Pyka-Fościak
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000276:immunology; D016676:Macrophages, Alveolar / Q000166:cytology / Q000276:immunology*; D012627:Sebaceous Glands / Q000166:cytology / Q000276:immunology*; D016707:Tissue Fixation
chemical_list: D000911:Antibodies, Monoclonal