title: Viral perturbations of host networks reflect disease etiology.
abstract: Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia.
authors: Center for Complex Networks Research-CCNR and Department of Physics, Northeastern University, Boston, Massachusetts, United States of America.
authors: Natali
authors: N
authors: Gulbahce
authors: Han
authors: H
authors: Yan
authors: Amélie
authors: A
authors: Dricot
authors: Megha
authors: M
authors: Padi
authors: Danielle
authors: D
authors: Byrdsong
authors: Rachel
authors: R
authors: Franchi
authors: Deok-Sun
authors: DS
authors: Lee
authors: Orit
authors: O
authors: Rozenblatt-Rosen
authors: Jessica C
authors: JC
authors: Mar
authors: Michael A
authors: MA
authors: Calderwood
authors: Amy
authors: A
authors: Baldwin
authors: Bo
authors: B
authors: Zhao
authors: Balaji
authors: B
authors: Santhanam
authors: Pascal
authors: P
authors: Braun
authors: Nicolas
authors: N
authors: Simonis
authors: Kyung-Won
authors: KW
authors: Huh
authors: Karin
authors: K
authors: Hellner
authors: Miranda
authors: M
authors: Grace
authors: Alyce
authors: A
authors: Chen
authors: Renee
authors: R
authors: Rubio
authors: Jarrod A
authors: JA
authors: Marto
authors: Nicholas A
authors: NA
authors: Christakis
authors: Elliott
authors: E
authors: Kieff
authors: Frederick P
authors: FP
authors: Roth
authors: Jennifer
authors: J
authors: Roecklein-Canfield
authors: James A
authors: JA
authors: Decaprio
authors: Michael E
authors: ME
authors: Cusick
authors: John
authors: J
authors: Quackenbush
authors: David E
authors: DE
authors: Hill
authors: Karl
authors: K
authors: Münger
authors: Marc
authors: M
authors: Vidal
authors: Albert-László
authors: AL
authors: Barabási
mesh_terms: D019295:Computational Biology; D004194:Disease / Q000209:etiology* / Q000235:genetics; D005199:Fanconi Anemia / Q000209:etiology / Q000235:genetics / Q000821:virology; D020022:Genetic Predisposition to Disease; D004854:Herpesvirus 4, Human / Q000378:metabolism / Q000472:pathogenicity; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000502:physiology; D052162:Human papillomavirus 16 / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D008954:Models, Biological; D060066:Protein Interaction Maps; D014764:Viral Proteins / Q000378:metabolism; D014777:Virus Diseases / Q000150:complications*
chemical_list: D014764:Viral Proteins