title: Tracking bisphosphonates through a 20 mm thick porcine tissue by using surface-enhanced spatially offset Raman spectroscopy.
abstract: Track it down: A recognized surface-enhanced Raman scattering (SERS) nanotag signal was monitored from a thin, dispersed layer of bisphosphonate-functionalized nanotags on a bone sample, through a 20 mm thick specimen of porcine muscle tissue by surface-enhanced spatial offset Raman spectroscopy (SESORS; see picture). The result demonstrates the great potential for non-invasive in vivo bisphosphonate drug tracking.
authors: Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK.
authors: Hai-nan
authors: HN
authors: Xie
authors: Ross
authors: R
authors: Stevenson
authors: Nicholas
authors: N
authors: Stone
authors: Aaron
authors: A
authors: Hernandez-Santana
authors: Karen
authors: K
authors: Faulds
authors: Duncan
authors: D
authors: Graham
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry*; D004164:Diphosphonates / Q000032:analysis* / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry* / Q000378:metabolism; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013552:Swine
chemical_list: D004164:Diphosphonates