title: Environmental hypothermia in porcine polytrauma and hemorrhagic shock is safe.
abstract: We have previously demonstrated survival benefit to induced hypothermia in a porcine model of controlled hemorrhagic shock simulating an associated delay to definitive care. In the current study, we wished to evaluate the effects of environmental hypothermia in a porcine model of hemorrhagic shock with the addition of polytrauma. Sixteen pigs were randomized to normothermic (39°C, n = 7) or hypothermic (34°C, n = 9) groups. The model included instrumentation, chest injury (captive bolt device), hemorrhage to systolic blood pressure (SBP) of ∼50 mmHg, and crush liver injury. Animals received limited fluid resuscitation for a 1-h period with goal SBP of greater than 80 mmHg and ice packs or warming blankets to achieve goal temperatures, followed by full resuscitation with goal SBP of greater than 90 mmHg, adequate urine output, and hemoglobin by protocol for 20 h. Survivors were observed for an additional 24 h with end points including mortality, markers of organ injury, and neurologic function. There were no differences in survival between the groups (mortality = 1/9, hypothermia group vs. 2/7, normothermia group, P = 0.39). Markers of organ injury were elevated in the hypothermia group at 24 h after injury but were identical between groups at the end of the experimental protocol (48 h after injury). There were no noted differences in neurologic function between the two groups. Environmental hypothermia in a model of polytrauma and hemorrhagic shock was not associated with worse outcomes.
authors: Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors: Uroghupatei P
authors: UP
authors: Iyegha
authors: Joseph J
authors: JJ
authors: Greenberg
authors: Kristine E
authors: KE
authors: Mulier
authors: Jeffrey
authors: J
authors: Chipman
authors: Mark
authors: M
authors: George
authors: Greg J
authors: GJ
authors: Beilman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007035:Hypothermia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D009104:Multiple Trauma / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D013552:Swine; D013997:Time Factors