title: [Prostate cancer with disseminated carcinomatosis of bone marrow initially presenting with disseminated intravascular coagulation syndrome: a case report].
abstract: A 56-year-old man was admitted to our hospital complaining of dyspnea, general fatigue and lumbago. Several examinations revealed severe pancytopenia with disseminated intravascular coagulation (DIC), multiple lymph node metastases, and extremely high serum prostate specific antigen (PSA) level. Hormonal therapy under a diagnosis of advanced prostate cancer was started. Bone marrow biopsy, performed for the assessment of pancytopenia, revealed that there were no hematopoietic cells but only diffuse infiltration of prostate cancer cells. His bone scintigraphy showed a super scan image. Therefore, our diagnosis was prostate cancer with disseminated carcinomatosis of bone marrow. Although the response to hormonal therapy had been initially good, the time to PSA nadir was 9 weeks and he died 34 weeks after the start of the treatment. To our knowledge, 20 cases of prostate cancer with disseminated carcinomatosis of bone marrow have been reported in the Japanese literature including this case and the clinical features are reviewed.
authors: The Department of Urology, Minoh City Hospital.
authors: Noriko
authors: N
authors: Minato
authors: Tsuyoshi
authors: T
authors: Takada
authors: Minoru
authors: M
authors: Koga
authors: Hideki
authors: H
authors: Sugao
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002277:Carcinoma / Q000150:complications / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen