title: Central nervous system aquaporin-4 autoimmunity presenting with an isolated cerebral abnormality.
abstract: Advances in the understanding of central nervous system aquarporin-4 autoimmunity have promoted the recognition of diverse clinical presentations beyond the traditional view of neuromyelitis optica. We describe a patient who developed hemiparesis caused by an extensive cerebral lesion as an initial manifestation of central nervous system aquarporin-4 autoimmunity. Although the patient had no history of optic neuritis or myelitis, not only was serum anti-aquarporin-4 antibody positive, but an imaging, treatment response and histopathological features also revealed characteristic findings suggestive of central nervous system aquarporin-4 autoimmunity. The present case highlights the importance of a comprehensive evaluation for anti-aquarporin-4 antibody even in patients presenting with isolated cerebral lesions.
authors: Department of Neurology, Research Institute and Hospital of National Cancer Center, Korea.
authors: Su-Hyun
authors: SH
authors: Kim
authors: Woojun
authors: W
authors: Kim
authors: Myeong-Cherl
authors: MC
authors: Kook
authors: Eun-kyung
authors: EK
authors: Hong
authors: Ho Jin
authors: HJ
authors: Kim
mesh_terms: D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D001706:Biopsy; D001921:Brain / Q000276:immunology* / Q000473:pathology*; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D010291:Paresis / Q000209:etiology; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies