title: Delayed action of serotonin in molluscan development.
abstract: Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT2-like type receptors are required for the appearence of these phenomena.
authors: Department of Comparative Physiology, Institute of Developmental Biology RAS, Moscow, Russia.
authors: Elena E
authors: EE
authors: Voronezhskaya
authors: Marina Yu
authors: MY
authors: Khabarova
authors: L P
authors: LP
authors: Nezlin
authors: E G
authors: EG
authors: Ivashkin
mesh_terms: D000818:Animals; D047108:Embryonic Development; D008124:Locomotion; D008195:Lymnaea / Q000196:embryology*; D012701:Serotonin / Q000502:physiology*
chemical_list: D012701:Serotonin