title: Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms.
abstract: Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with neurocognitive impairments. The neural substrates of cognitive impairments in 22q11DS remain poorly understood. Because the corpus callosum (CC) is found to be abnormal in a variety of neurodevelopmental disorders, we obtained volumetric measurements of the CC and its subregions, examined the relationship between these regions and neurocognition and selected genotypes within candidate genes in the 22q11.2 interval in 59 children with 22q11DS and 53 control subjects. The total CC, splenium and genu were significantly larger in children with 22q11DS and the enlargement was associated with better neurocognitive functioning in the 22q11DS group, suggestive of a compensatory increase in the CC volumes. The expected age-related increase in the volume of the CC was not seen in children with 22q11DS, indicative of dysmaturation of the CC in these children. The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with polymorphisms within the candidate genes: COMT (rs4680), ZDHHC8 (rs175174) and UFD1L (rs5992403). These findings indicate that alterations in the CC volume in children with 22q11DS are associated with cognition and specific genotypes in the 22q11.2 interval.
authors: Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. Vandana.shashi@duke.edu
authors: Vandana
authors: V
authors: Shashi
authors: Alan
authors: A
authors: Francis
authors: Stephen R
authors: SR
authors: Hooper
authors: Peter G
authors: PG
authors: Kranz
authors: Michael
authors: M
authors: Zapadka
authors: Kelly
authors: K
authors: Schoch
authors: Edward
authors: E
authors: Ip
authors: Neeraj
authors: N
authors: Tandon
authors: Timothy D
authors: TD
authors: Howard
authors: Matcheri S
authors: MS
authors: Keshavan
mesh_terms: D000217:Acyltransferases / Q000235:genetics; D033942:Adaptor Proteins, Vesicular Transport; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D003337:Corpus Callosum / Q000473:pathology*; D004062:DiGeorge Syndrome / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D009929:Organ Size / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; C491497:UFD1 protein, human; D002394:Catechol O-Methyltransferase; D000217:Acyltransferases; C488097:ZDHHC8 protein, human