title: Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus.
abstract: Na-FAR-1 is an unusual α-helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.
authors: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland. mgabr@chem.gla.ac.uk
authors: Mads
authors: M
authors: Gabrielsen
authors: M Florencia
authors: MF
authors: Rey-Burusco
authors: Kate
authors: K
authors: Griffiths
authors: Andrew J
authors: AJ
authors: Roe
authors: Alan
authors: A
authors: Cooper
authors: Brian O
authors: BO
authors: Smith
authors: Malcolm W
authors: MW
authors: Kennedy
authors: Betina
authors: B
authors: Corsico
mesh_terms: D000818:Animals; D003460:Crystallization; D050556:Fatty Acid-Binding Proteins / Q000737:chemistry*; D015801:Helminth Proteins / Q000737:chemistry*; D017221:Necator americanus / Q000737:chemistry*
chemical_list: D050556:Fatty Acid-Binding Proteins; D015801:Helminth Proteins