title: Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?
abstract: OBJECTIVE
  To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Cohort.
  
  
  METHODS
  Academic practice.
  
  
  METHODS
  A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects.
  
  
  METHODS
  Blood and ovarian ultrasound at baseline and after 5 years. MAJOR OUTCOME MEASURE(S): Serum antimüllerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound.
  
  
  RESULTS
  After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH ≤ 4 ng/mL was associated with ovulatory function.
  
  
  CONCLUSIONS
  Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.
authors: Department of Medical and Biological Sciences, University of Palermo, Palermo, Italy.
authors: Enrico
authors: E
authors: Carmina
authors: Anna Maria
authors: AM
authors: Campagna
authors: Pasquale
authors: P
authors: Mansuet
authors: Giustina
authors: G
authors: Vitale
authors: Daniel
authors: D
authors: Kort
authors: Roger
authors: R
authors: Lobo
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D000728:Androgens / Q000097:blood; D000858:Anovulation / Q000097:blood / Q000503:physiopathology; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008875:Middle Aged; D010053:Ovary / Q000000981:diagnostic imaging / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D000728:Androgens; D015415:Biomarkers; D006062:Gonadotropins; D054304:Anti-Mullerian Hormone