title: Syntheses of novel diaryl[d,f ][1,3]diazepines via one-pot Suzuki coupling followed by direct ring closure with carboxylic acids.
abstract: A series of novel and diverse diaryl[d,f][1,3]diazepines were designed and synthesized to expand the pharmaceutical utility of the [6,7]bicyclic molecular skeletons. The facile synthesis involved two key steps: a one-pot Suzuki coupling to construct the bi-aryl intermediates from corresponding halides, and a ring closure by direct condensation with carboxylic acids.
authors: The Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, Changchun, 130012 Jilin, People's Republic of China.
authors: Longjia
authors: L
authors: Yan
authors: Xin
authors: X
authors: Che
authors: Xu
authors: X
authors: Bai
authors: Yazhong
authors: Y
authors: Pei
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic
chemical_list: D001381:Azepines; D002264:Carboxylic Acids