title: Activity-dependent energy budget for neocortical signaling: effect of short-term synaptic plasticity on the energy expended by spiking and synaptic activity.
abstract: The available estimate of the energy expended for signaling in rat neocortex is refined to examine the separate contribution of spiking and synaptic activity as a function of average neuronal firing rate. By taking into account a phenomenological model of short-term synaptic plasticity, we show that the transition from low to high cortical activity is accompanied by a substantial increase in relative energy consumed by action potentials vs. synaptic potentials. This consideration might be important for a deeper understanding of how information is represented in the cortex and which metabolic pathways are upregulated to sustain cortical activity.
authors: MARBILab, Museo storico della fisica e Centro di studi e ricerche "Enrico Fermi," Rome, Italy. mauro.dinuzzo@roma1.infn.it
authors: Mauro
authors: M
authors: DiNuzzo
authors: Federico
authors: F
authors: Giove
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D008959:Models, Neurological; D019579:Neocortex / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D055366:Synaptic Potentials / Q000502:physiology*