title: Therapeutic implications of small interfering RNA in cardiovascular diseases.
abstract: Cardiovascular diseases (CVDs) place a heavy burden on the economies of low- and middle-income countries. Comprehensive action requires combining approaches that seek to reduce the risks throughout the entire population with strategies that target individuals at high risk or with established disease. Small interfering RNA (siRNA) as a functional mediator for regulation of gene expression has been evaluated for potential therapeutic targets for the treatment of various cardiovascular diseases such as hypertension, atherosclerosis, heart failure etc. The present review attempts have been made to provide a brief outline of the current understanding of the mechanism of RNAi and the delivery system and describe the therapeutic application of siRNAs and their potential for treating CVDs which are taking a heavy toll on human life.
authors: Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
authors: Suchi
authors: S
authors: Raghunathan
authors: Bhoomika M
authors: BM
authors: Patel
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D005786:Gene Expression Regulation; D020868:Gene Silencing; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex / Q000378:metabolism
chemical_list: D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex