title: An overview of the chemistry and biology of reactive aldehydes.
abstract: The nonenzymatic free radical generation of reactive aldehydes is known to contribute to diseases of sustained oxidative stress including rheumatoid arthritis, atherosclerosis, neurodegeneration, and a number of liver diseases. At the same time, the accumulation of lipid electrophiles has been demonstrated to play a role in cell signaling events through modification of proteins critical for cellular homeostasis. Given the broad scope of reactivity profiles and the ability to modify numerous proteomic and genomic processes, new emphasis is being placed on a systems-based analysis of the consequences of electrophilic adduction. This review focuses on the generation and chemical reactivity of lipid-derived aldehydes with a special focus on the homeostatic responses to electrophilic stress.
authors: Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver Anschutz Medical Center, 12850 E. Montview Blvd, Campus Box C-238, Aurora, CO 80045, USA.
authors: Kristofer S
authors: KS
authors: Fritz
authors: Dennis R
authors: DR
authors: Petersen
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000737:chemistry
chemical_list: D000447:Aldehydes; D005609:Free Radicals; D008055:Lipids