title: Receptor for advanced glycation end products (RAGE) and glyoxalase I gene polymorphisms in pathological pregnancy.
abstract: OBJECTIVE
  The aim of the study was to analyze polymorphisms of receptor for advanced glycation end products (RAGE) gene, and glyoxalase I gene and soluble RAGE, sRAGE, in physiological and pathological pregnancy.
  
  
  METHODS
  Polymorphisms of RAGE gene (-429 T/C, -374 T/A, 557 G/A, 2184 A/G) and glyoxalase I gene (A419C) and sRAGE serum levels were determined in 284 women with pathological and physiological pregnancy.
  
  
  RESULTS
  No differences in distribution of genotype and allelic frequencies of studied polymorphisms were found. GA genotype of RAGE 557 G/A polymorphism (known as Gly82Ser) is associated with lower sRAGE serum levels in healthy pregnant women compared to GG genotype (483 ± 104 vs. 692 ± 262 pg/mL, p=0.008). sRAGE correlates negatively with ALT in patients with pregnancy intrahepatic cholestasis (r=-0.536, p=0.05).
  
  
  CONCLUSIONS
  We did not show any association of RAGE and glyoxalase I gene polymorphisms with pathological pregnancy, however further studies are needed to confirm the results.
authors: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08, Prague, Czech Republic.
authors: Anna
authors: A
authors: Germanová
authors: Alexandra
authors: A
authors: Muravská
authors: Marie
authors: M
authors: Jáchymová
authors: Zdeněk
authors: Z
authors: Hájek
authors: Michal
authors: M
authors: Koucký
authors: Oto
authors: O
authors: Mestek
authors: Tomáš
authors: T
authors: Zima
authors: Marta
authors: M
authors: Kalousová
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D007752:Obstetric Labor, Premature / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000235:genetics; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D000410:Alanine Transaminase; D007791:Lactoylglutathione Lyase