title: Orthokeratology vs. spectacles: adverse events and discontinuations.
abstract: OBJECTIVE
  To assess the relative clinical success of orthokeratology contact lenses (OK) and distance single-vision spectacles (SV) in children in terms of incidences of adverse events and discontinuations over a 2-year period.
  
  
  METHODS
  Sixty-one subjects 6 to 12 years of age with myopia of - 0.75 to - 4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or SV correction. Subjects were followed at 6-month intervals and advised to report to the clinic immediately should adverse events occur. Adverse events were categorized into serious, significant, and non-significant. Discontinuation was defined as cessation of lens wear for the remainder of the study.
  
  
  RESULTS
  Thirty-one children were corrected with OK and 30 with SV. A higher incidence of adverse events was found with OK compared with SV (p < 0.001). Nine OK subjects experienced 16 adverse events (7 significant and 9 non-significant). No adverse events were found in the SV group. Most adverse events were found between 6 and 12 months of lens wear, with 11 solely attributable to OK wear. Significantly more discontinuations were found with SV in comparison with OK (p < 0.05).
  
  
  CONCLUSIONS
  The relatively low incidence of adverse events and discontinuations with OK is conducive for the correction of myopia in children with OK contact lenses.
authors: Menicon Co., Ltd. (Madrid Office), Madrid, Spain. j.santodomingo@menicon.com
authors: Jacinto
authors: J
authors: Santodomingo-Rubido
authors: César
authors: C
authors: Villa-Collar
authors: Bernard
authors: B
authors: Gilmartin
authors: Ramón
authors: R
authors: Gutiérrez-Ortega
mesh_terms: D001251:Astigmatism / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003316:Corneal Diseases / Q000453:epidemiology / Q000209:etiology*; D005139:Eyeglasses / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D054158:Orthokeratologic Procedures / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D012029:Refraction, Ocular; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology