title: Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture.
abstract: Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-κB signaling and increased production of IL1β and nitric oxide (NO). IL1β classically an inflammatory cytokine surprisingly did not increase but inhibited LPS+IFNγ-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation.
authors: Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago, Chile.
authors: B
authors: B
authors: Godoy
authors: P
authors: P
authors: Murgas
authors: J
authors: J
authors: Tichauer
authors: R
authors: R
authors: Von Bernhardi
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D007371:Interferon-gamma / Q000494:pharmacology; D053583:Interleukin-1beta / Q000378:metabolism*; D008024:Ligands; D008070:Lipopolysaccharides / Q000494:pharmacology; D020935:MAP Kinase Signaling System / Q000502:physiology; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D051117:Scavenger Receptors, Class A / Q000096:biosynthesis*
chemical_list: D053583:Interleukin-1beta; D008024:Ligands; D008070:Lipopolysaccharides; D016328:NF-kappa B; D051117:Scavenger Receptors, Class A; D009569:Nitric Oxide; D007371:Interferon-gamma