title: 3D Slicer as an image computing platform for the Quantitative Imaging Network.
abstract: Quantitative analysis has tremendous but mostly unrealized potential in healthcare to support objective and accurate interpretation of the clinical imaging. In 2008, the National Cancer Institute began building the Quantitative Imaging Network (QIN) initiative with the goal of advancing quantitative imaging in the context of personalized therapy and evaluation of treatment response. Computerized analysis is an important component contributing to reproducibility and efficiency of the quantitative imaging techniques. The success of quantitative imaging is contingent on robust analysis methods and software tools to bring these methods from bench to bedside. 3D Slicer is a free open-source software application for medical image computing. As a clinical research tool, 3D Slicer is similar to a radiology workstation that supports versatile visualizations but also provides advanced functionality such as automated segmentation and registration for a variety of application domains. Unlike a typical radiology workstation, 3D Slicer is free and is not tied to specific hardware. As a programming platform, 3D Slicer facilitates translation and evaluation of the new quantitative methods by allowing the biomedical researcher to focus on the implementation of the algorithm and providing abstractions for the common tasks of data communication, visualization and user interface development. Compared to other tools that provide aspects of this functionality, 3D Slicer is fully open source and can be readily extended and redistributed. In addition, 3D Slicer is designed to facilitate the development of new functionality in the form of 3D Slicer extensions. In this paper, we present an overview of 3D Slicer as a platform for prototyping, development and evaluation of image analysis tools for clinical research applications. To illustrate the utility of the platform in the scope of QIN, we discuss several use cases of 3D Slicer by the existing QIN teams, and we elaborate on the future directions that can further facilitate development and validation of imaging biomarkers using 3D Slicer.
authors: Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. fedorov@bwh.harvard.edu
authors: Andriy
authors: A
authors: Fedorov
authors: Reinhard
authors: R
authors: Beichel
authors: Jayashree
authors: J
authors: Kalpathy-Cramer
authors: Julien
authors: J
authors: Finet
authors: Jean-Christophe
authors: JC
authors: Fillion-Robin
authors: Sonia
authors: S
authors: Pujol
authors: Christian
authors: C
authors: Bauer
authors: Dominique
authors: D
authors: Jennings
authors: Fiona
authors: F
authors: Fennessy
authors: Milan
authors: M
authors: Sonka
authors: John
authors: J
authors: Buatti
authors: Stephen
authors: S
authors: Aylward
authors: James V
authors: JV
authors: Miller
authors: Steve
authors: S
authors: Pieper
authors: Ron
authors: R
authors: Kikinis
mesh_terms: D001331:Automation; D015415:Biomarkers / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology; D016208:Databases, Factual; D003952:Diagnostic Imaging / Q000379:methods*; D005909:Glioblastoma / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008490:Medical Informatics / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology; D012984:Software; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D015415:Biomarkers