title: Pharmacoeconomic issues in psoriatic arthritis.
abstract: Therapies for psoriatic arthritis were inadequate until a short time ago. Nonsteroidal antiinflammatory drugs are helpful in relieving symptoms but do not prevent joint damage. Traditional disease-modifying antirheumatic drugs are used to control symptoms, but there is no evidence that they prevent or significantly slow the progression of structural damage in peripheral joints. The introduction of tumor necrosis factor-α (TNF-α) blocking agents has opened new horizons. These drugs lessen signs and symptoms of inflammation, enhance functional capacity and quality of life, and inhibit structural joint damage. On the other hand, TNF-α blockers are very costly and not easily available to all patients, whether they rely on a national health system or on private insurance. Pharmacoeconomic studies on these drugs so far have shown that they are cost-effective on both the musculoskeletal and skin manifestations of psoriatic disease, offering good value for money.
authors: Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy. ignazioolivieri@tiscalinet.it
authors: Ignazio
authors: I
authors: Olivieri
authors: Salvatore
authors: S
authors: D'Angelo
authors: Carlo
authors: C
authors: Palazzi
authors: Angela
authors: A
authors: Padula
authors: Ennio
authors: E
authors: Lubrano
authors: Lorenzo Giovanni
authors: LG
authors: Mantovani
mesh_terms: D000893:Anti-Inflammatory Agents / Q000191:economics* / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000188:drug therapy* / Q000191:economics* / Q000276:immunology; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D006297:Health Services Accessibility / Q000191:economics; D006801:Humans; D007596:Joints / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D019057:Quality-Adjusted Life Years; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha