title: Combined macro-/mesoporous microelectrode arrays for low-noise extracellular recording of neural networks.
abstract: Microelectrode arrays (MEAs) are appealing tools to probe large neural ensembles and build neural prostheses. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, several major problems become limiting factors when the size of the microelectrodes decreases. In particular, regarding recording of neural activity, the intrinsic noise level of a microelectrode dramatically increases when the size becomes small (typically below 20-μm diameter). Here, we propose to overcome this limitation using a template-based, single-scale meso- or two-scale macro-/mesoporous modification of the microelectrodes, combining the advantages of an overall small geometric surface and an active surface increased by several orders of magnitude. For this purpose, standard platinum MEAs were covered with a highly porous platinum overlayer obtained by lyotropic liquid crystal templating possibly in combination with a microsphere templating approach. These porous coatings were mechanically more robust than Pt-black coating and avoid potential toxicity issues. They had a highly increased active surface, resulting in a noise level ∼3 times smaller than that of conventional flat electrodes. This approach can thus be used to build highly dense arrays of small-size microelectrodes for sensitive neural signal detection.
authors: Université Bordeaux, ISM, UMR5255, Bordeaux, France.
authors: Matthias
authors: M
authors: Heim
authors: Lionel
authors: L
authors: Rousseau
authors: Stéphane
authors: S
authors: Reculusa
authors: Veronika
authors: V
authors: Urbanova
authors: Claire
authors: C
authors: Mazzocco
authors: Sébastien
authors: S
authors: Joucla
authors: Laurent
authors: L
authors: Bouffier
authors: Karel
authors: K
authors: Vytras
authors: Philip
authors: P
authors: Bartlett
authors: Alexander
authors: A
authors: Kuhn
authors: Blaise
authors: B
authors: Yvert
mesh_terms: D000818:Animals; D008564:Membrane Potentials; D051379:Mice; D046228:Microarray Analysis; D008839:Microelectrodes; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques