title: Construction of functionalized 2,3-dihydro-1,4-benzoxazines via [5 + 1] annulations of 2-halo-1,3-dicarbonyl compounds with imines.
abstract: A series of functionalized 2,3-dihydro-1,4-benzoxazines were obtained in moderate to excellent yields via domino [5 + 1] annulations of 2-halo-1,3-dicarbonyl compounds 2 with imines 1 under mild conditions and the application of this method in the synthesis of bioactive analogues, such as functionalized tetracyclic-1,4-benzoxazines which contain two new heterocyclic rings and one quaternary carbon center has also been developed.
authors: Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, P.R. of China.
authors: Ya-Ru
authors: YR
authors: Zhang
authors: Jian-Wu
authors: JW
authors: Xie
authors: Xu-Jiao
authors: XJ
authors: Huang
authors: Wei-Dong
authors: WD
authors: Zhu
mesh_terms: D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D006219:Halogens / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D048588:Benzoxazines; D006219:Halogens; D006571:Heterocyclic Compounds; D007097:Imines