title: Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and cytokine expression in SZ95 sebocytes.
abstract: Acne vulgaris is the most common disease of the pilosebaceous unit. The pathogenesis of this inflammatory disease is complex, involving increased sebum production and perifollicular inflammation. To identify effective agents for factors that induce acne vulgaris, we explored the pharmacological potential of epigallocatechin-3-gallate (EGCG), which has been widely investigated as an anti-proliferative and anti-inflammatory agent. In this study, we demonstrated that topical application of EGCG to rabbit auricles reduced the size of the sebaceous glands. When applied to cultured human SZ95 sebocytes, EGCG strongly suppressed cell proliferation and lipogenesis. These actions of EGCG were reproduced in IGF-I-differentiated SZ95 sebocytes. To investigate the anti-inflammatory potential of EGCG, we evaluated pro-inflammatory cytokine synthesis in IGF-I-differentiated SZ95 sebocytes and found that expression of IL-1, IL-6, and IL-8 was decreased. These results provide early evidence that EGCG is an effective candidate for acne therapy whose mechanisms of action in IGF-I-differentiated SZ95 sebocytes include the inhibition of lipogenesis and inflammation.
authors: Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea.
authors: Myung
authors: M
authors: Im
authors: Soo Y
authors: SY
authors: Kim
authors: Kyung C
authors: KC
authors: Sohn
authors: Dae K
authors: DK
authors: Choi
authors: Young
authors: Y
authors: Lee
authors: Young J
authors: YJ
authors: Seo
authors: Chang D
authors: CD
authors: Kim
authors: Yul L
authors: YL
authors: Hwang
authors: Christos C
authors: CC
authors: Zouboulis
authors: Jeung H
authors: JH
authors: Lee
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002461:Cell Line, Transformed; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D054644:Ear Auricle / Q000166:cytology / Q000187:drug effects; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007375:Interleukin-1 / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D016209:Interleukin-8 / Q000276:immunology / Q000378:metabolism; D050155:Lipogenesis / Q000187:drug effects* / Q000276:immunology; D011817:Rabbits; D012627:Sebaceous Glands / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D012629:Sebum / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D007334:Insulin-Like Growth Factor I; D002392:Catechin; C045651:epigallocatechin gallate