title: An association study between polymorphisms of the fractalkine receptor gene, CX3CR1, and cerebral infarction in the Han Chinese population.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between polymorphisms of CX3CR1 and the occurrence, neurological rehabilitation and 3-month outcome of cerebral infarction in the Han Chinese population.
  
  
  METHODS
  We investigated the V249I and T280M mutations of CX3CR1 in 308 consecutive Han Chinese patients that were diagnosed with cerebral infarction and 294 age- and gender-matched healthy control subjects. The patients were classified with Oxfordshire Community Stroke Project (OCSP) classification, evaluated with a National Institute of Health Stroke Scale (NIHSS) score for an acute stage of stroke and assessed with a Barthel Index (BI) score 3months after stroke. Polymorphic genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  We found no statistically significant difference in the V249I and T280M polymorphisms between the patients and controls. The I249 and M280 allele frequencies of CX3CR1 were not significantly different between the patients and controls. No differences were observed in the genotype distributions and allele frequencies of CX3CR1 among the OCSP stroke subtypes. No statistically significant association was found between the polymorphisms of CX3CR1 and NIHSS scores of cerebral infarction at the acute stage or with the 3-month BI scores obtained after cerebral infarction.
  
  
  CONCLUSIONS
  Our results demonstrated that the polymorphisms of CX3CR1 might not associate with the occurrence, neurological rehabilitation and 3-month outcome of cerebral infarction in the Han Chinese population.
authors: Neurology Department of the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 51900, China. lizdsysu@163.com
authors: Zhendong
authors: Z
authors: Li
authors: Shijian
authors: S
authors: Luo
authors: Feng
authors: F
authors: Wang
authors: Jun
authors: J
authors: Zhen
authors: Huabin
authors: H
authors: Sun
authors: Chunlian
authors: C
authors: Guo
mesh_terms: D044466:Asian People / Q000235:genetics*; D000073883:CX3C Chemokine Receptor 1; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics* / Q000534:rehabilitation; D005260:Female; D056726:Genetic Association Studies / Q000379:methods / Q000706:statistics & numerical data*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D019707:Receptors, Chemokine / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine