title: Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles.
abstract: The targeted delivery of anticancer agents is a promising field in anticancer therapy. Mesenchymal stem cells (MSCs) have inherent tumor-tropic and migratory properties, which allow them to serve as vehicles for targeted drug delivery systems for isolated tumors and metastatic diseases. MSCs have been successfully studied and discussed as a vehicle for cancer gene therapy. However, MSCs have not yet been discussed adequately as a potential vehicle for traditional anticancer drugs. In this review, we will examine the potential of MSCs as a targeted-delivery vehicle for anticancer drug-loaded nanoparticles (NPs), summarize various challenges, and discuss possible solutions for these challenges.
  
  
  BACKGROUND
  In this review, the feasibility of mesenchymal stem cell-based targeted delivery of anticancer agents is discussed.
authors: Department of Pharmacy, Hebei University of Science and Technology, Shijiazhuang, PR China. zbgao74@163.com
authors: Zibin
authors: Z
authors: Gao
authors: Linan
authors: L
authors: Zhang
authors: Jie
authors: J
authors: Hu
authors: Yongjun
authors: Y
authors: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D053758:Nanoparticles / Q000032:analysis*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents