title: [Effect of preparation "Korargin" on metabolic syndrome manifestations in adult and old rats exposed to x-ray irradiation].
abstract: Introduction to the diet of adult and old rats for 30 days after R-irradiation at a dose of 5 Gy drug "Korargin" prevented the development of some manifestations of radioinduced metabolic syndrome (MS) in animals of both age groups: in adult irradiated animals--a tendency to decrease insulin levels in blood plasma, increase of cholesterol levels in liver tissue, significantly increased serum high density lipoprotein as compared both to controls and irradiated animals, prevented the decrease in the levels of anions NO2- and NO3- in tissue of the aorta and anions NO2- in tissue of the heart; in old irradiated animals--prevented tended to increase of body weight, the increase in insulinresistance (index HOMA), the decrease in the level of anions NO2- in the aorta tissue, increased levels of anions NO2- and NO3- in the heart tissue compared to controls. Prevention through drug "Korargin" some manifestations of radioinduced MS in adult and old animals, indicates the prospects of exploring the possibility of correction of the violations of carbohydrate and lipid metabolism caused by exposure to ionizing radiation, in individuals of both age groups.
authors: E N
authors: EN
authors: Gorban'
authors: N V
authors: NV
authors: Topol'nikova
authors: E V
authors: EV
authors: Pod''achenko
authors: N V
authors: NV
authors: Osipov
mesh_terms: D000367:Age Factors; D000818:Animals; D000838:Anions; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D001120:Arginine / Q000008:administration & dosage / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D002784:Cholesterol / Q000097:blood; D006321:Heart / Q000187:drug effects / Q000528:radiation effects; D007288:Inosine / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000528:radiation effects; D050356:Lipid Metabolism / Q000187:drug effects* / Q000528:radiation effects; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014965:X-Rays
chemical_list: D000838:Anions; D007328:Insulin; D008075:Lipoproteins, HDL; D009566:Nitrates; D009573:Nitrites; D011837:Radiation-Protective Agents; D007288:Inosine; D001120:Arginine; D002784:Cholesterol