title: Scheduled perioperative switch from oral sildenafil to intravenous epoprostenol in a patient with Eisenmenger syndrome undergoing a sigmoidectomy.
abstract: The perioperative management of pulmonary hypertension in a patient with Eisenmenger syndrome, the most advanced form of associated pulmonary artery hypertension (PAH), who required a sigmoidectomy is presented. The treatment for pulmonary hypertension was switched from oral sildenafil to intravenous epoprostenol to avoid the unexpected discontinuation of vasodilation during the perioperative period. The scheduled perioperative conversion should be considered for patients with severe PAH undergoing major abdominal surgery to ensure the stabilization of pulmonary and systemic hemodynamics.
authors: Department of Anesthesiology, Kyorin University Faculty of Medicine, Tokyo 181-8611, Japan. mokiyo@ks.kyorin-u.ac.jp
authors: Kiyoshi
authors: K
authors: Moriyama
authors: Koji
authors: K
authors: Uzawa
authors: Takehiko
authors: T
authors: Iijima
authors: Mariko
authors: M
authors: Kotani
authors: Kumi
authors: K
authors: Moriyama
authors: Yuki
authors: Y
authors: Ohashi
authors: Toru
authors: T
authors: Satoh
authors: Tomoko
authors: T
authors: Yorozu
mesh_terms: D000284:Administration, Oral; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003082:Colectomy / Q000379:methods; D004541:Eisenmenger Complex / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D065627:Familial Primary Pulmonary Hypertension; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care / Q000379:methods; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011687:Purines / Q000008:administration & dosage / Q000627:therapeutic use; D012811:Sigmoid Neoplasms / Q000601:surgery; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D011464:Epoprostenol