title: Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method.
abstract: Accurate and sensitive methods were developed for simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium in their binary mixtures, and in the presence of a methocarbamol related substance (guaifenesin) using mean centering of the ratio spectra method. The results obtained were statistically compared with the reported HPLC methods; no significant difference between the proposed methods and the reported methods was found regarding either accuracy or precision.
authors: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. dr.nourali@hotmail.com
authors: Nouruddin Wageih
authors: NW
authors: Ali
authors: Maha Ahamd
authors: MA
authors: Hegazy
authors: Mohamed
authors: M
authors: Abdelkawy
authors: Eglal Abdelahamid
authors: EA
authors: Abdelaleem
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003205:Computing Methodologies; D004008:Diclofenac / Q000032:analysis*; D004338:Drug Combinations; D004355:Drug Stability; D005100:Expectorants / Q000032:analysis; D006140:Guaifenesin / Q000032:analysis; D007052:Ibuprofen / Q000032:analysis*; D057230:Limit of Detection; D008721:Methocarbamol / Q000032:analysis*; D009125:Muscle Relaxants, Central / Q000032:analysis*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D005100:Expectorants; D009125:Muscle Relaxants, Central; D013607:Tablets; D008721:Methocarbamol; D004008:Diclofenac; D006140:Guaifenesin; D007052:Ibuprofen