title: Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter.
abstract: OBJECTIVE
  To compare efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in shelter-housed cats with clinical signs of upper respiratory tract disease (URTD).
  
  
  METHODS
  Randomized prospective clinical trial. Animals-48 cats with URTD.
  
  
  METHODS
  Conjunctival and nasal swab specimens were obtained for culture and susceptibility testing, and cats were randomly assigned to 3 treatment groups (16 cats/group) on day 1: amoxicillin-clavulanic acid (12.5 mg/kg [5.68 mg/lb], PO, q 12 h, for 14 days), cefovecin (8.0 mg/kg [3.64 mg/lb], SC, once), or doxycycline (10.0 mg/kg [4.55 mg/lb], PO, q 24 h, for 14 days). Oculonasal discharge, sneezing, coughing, dyspnea, demeanor, and food intake were scored twice daily for 14 days (scale, 0 [subjectively normal] to 3 [markedly abnormal]).
  
  
  RESULTS
  The most common bacterial isolates were Mycoplasma spp (n = 22) and Bordetella bronchiseptica (9). Cats treated with amoxicillin-clavulanic acid or doxycycline had significantly increased body weight by day 14. Cats that received doxycycline had significantly lower overall oculonasal discharge scores than those treated with amoxicillin-clavulanic acid or cefovecin. Cats treated with amoxicillin-clavulanic acid or doxycycline had significantly lower overall sneezing scores than those that received cefovecin. Cats that received amoxicillin-clavulanic acid had significantly decreased demeanor and food intake scores on day 2, whereas this was detected later in other groups (demeanor score on days 5 and 7 and food intake score on days 10 and 11 in the cefovecin and doxycycline groups, respectively).
  
  
  CONCLUSIONS
  Oral administration of amoxicillin-clavulanic acid or doxycycline appeared to be more effective than a single SC injection of cefovecin in treating cats with clinical signs of URTD.
authors: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA. catvet@purdue.edu
authors: Annette L
authors: AL
authors: Litster
authors: Ching Ching
authors: CC
authors: Wu
authors: Peter D
authors: PD
authors: Constable
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002511:Cephalosporins / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006799:Housing, Animal; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C516253:cefovecin; D019980:Amoxicillin-Potassium Clavulanate Combination; D004318:Doxycycline