title: NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis.
abstract: BACKGROUND
  Rheumatoid arthritis (RA) is an inflammatory disease associated with increased cardiovascular (CV) mortality. A recent study has disclosed association between NFKB1-94ATTG ins/del polymorphism and higher risk of coronary heart disease in healthy Caucasians. Because of that, we assessed the influence of this polymorphism in the risk of CV disease in RA patients.
  
  
  METHODS
  1437 Spanish patients with RA were genotyped for the NFKB1-94ATTG ins/del polymorphism. Two hundred and seventy-one of them (18.8%) had experienced CV events.
  
  
  RESULTS
  After adjusting for sex, age at RA diagnosis and traditional CV risk factors RA patients carrying the NFKB1 del/del genotype had higher risk of CV events than those with ins/ins genotype (Hazard ratio [HR] = 1.76, 95% CI: 1.05-2.97, p = 0.03), while heterozygous patients had an intermediate (but non-significant) risk (HR = 1.31, 95% CI: 0.90-1.92, p = 0.16).
  
  
  CONCLUSIONS
  Our results suggest that NFKB1-94ATTG ins/del polymorphism is associated with CV disease in patients with RA.
authors: Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, s/n 39008 Santander, Spain.
authors: Raquel
authors: R
authors: López-Mejías
authors: Mercedes
authors: M
authors: García-Bermúdez
authors: Carlos
authors: C
authors: González-Juanatey
authors: Santos
authors: S
authors: Castañeda
authors: José A
authors: JA
authors: Miranda-Filloy
authors: Carmen
authors: C
authors: Gómez-Vaquero
authors: Benjamín
authors: B
authors: Fernández-Gutiérrez
authors: Alejandro
authors: A
authors: Balsa
authors: Dora
authors: D
authors: Pascual-Salcedo
authors: Ricardo
authors: R
authors: Blanco
authors: Isidoro
authors: I
authors: González-Álvaro
authors: Javier
authors: J
authors: Llorca
authors: Javier
authors: J
authors: Martín
authors: Miguel A
authors: MA
authors: González-Gay
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain; D013997:Time Factors
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human