title: CyberKnife with Tumor Tracking: An Effective Treatment for High-Risk Surgical Patients with Single Peripheral Lung Metastases.
abstract: Standard treatment for operable patients with single peripheral lung metastases is metastasectomy. We report mature CyberKnife outcomes for high-risk surgical patients with biopsy proven single peripheral lung metastases. Twenty-four patients (median age 73 years) with a mean maximum tumor diameter of 2.5 cm (range, 0.8-4.5 cm) were treated over a 6-year period extending from September 2004 to September 2010 and followed for a minimum of 1 year or until death. A mean dose of 52 Gy (range, 45-60 Gy) was delivered to the prescription isodose line in three fractions over a 3-11 day period (mean, 7 days). At a median follow-up of 20 months, the 2-year Kaplan-Meier local control and overall survival rates were 87 and 50%, respectively. CyberKnife with fiducial tracking is an effective treatment for high-risk surgical patients with single small peripheral lung metastases. Trials comparing CyberKnife with metastasectomy for operable patients are necessary to confirm equivalence.
authors: Department of Radiation Medicine, Georgetown University Hospital Washington, DC, USA.
authors: James W
authors: JW
authors: Snider
authors: Eric K
authors: EK
authors: Oermann
authors: Viola
authors: V
authors: Chen
authors: Jennifer
authors: J
authors: Rabin
authors: Simeng
authors: S
authors: Suy
authors: Xia
authors: X
authors: Yu
authors: Saloomeh
authors: S
authors: Vahdat
authors: Sean P
authors: SP
authors: Collins
authors: Filip
authors: F
authors: Banovac
authors: Eric
authors: E
authors: Anderson
authors: Brian T
authors: BT
authors: Collins