title: Bioactive alkaloids produced by Pseudomonas brassicacearum subsp. Neoaurantiaca, an endophytic bacterium from Salvia miltiorrhiza.
abstract: Eleven compounds were isolated from the culture of an endophytic bacterium Pseudomonas brassicacearum subsp. Neoaurantiaca in Salvia miltiorrhiza Bunge. Their structures were elucidated by spectroscopic methods as cyclo-(Gly-L-Ala) (1), cyclo-(L-Ala-L-Ala) (2), cyclo-(L-Pro-Gly) (3), cyclo-(L-Pro-L-Ser) (4), cyclo-(L-Ala-trans-4-hydroxy-L-Pro) (5), cyclo-(L-Val-L-Pro) (6), cyclo-(Gly-L-Tyr) (7), cyclo-(L-Ala-L-Tyr) (8), cyclo-(L-Tyr-trans-4-hydroxy-L-Pro) (9), 3-methylhydantoin (10) and 2-piperidinone (11). All these compounds were isolated from this bacterium for the first time. The brine shrimp lethality, antifungal and antibacterial activities of these compounds were evaluated. The results indicated that some cyclodipeptides may play an important role in plant-bacteria interactions.
authors: Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi, PR China.
authors: Xiao-Jun
authors: XJ
authors: Li
authors: Hao-Yu
authors: HY
authors: Tang
authors: Jia-Li
authors: JL
authors: Duan
authors: Jin-Ming
authors: JM
authors: Gao
authors: Quan-Hong
authors: QH
authors: Xue
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D015394:Molecular Structure; D011549:Pseudomonas / Q000737:chemistry* / Q000502:physiology*; D027561:Salvia miltiorrhiza / Q000382:microbiology*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents