title: Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis.
abstract: BACKGROUND
  Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis.
  
  
  METHODS
  We investigated the dipole moment of M100 auditory evoked response using a magnetoencephalography in 18 patients with schizophrenia, 16 ultra-high-risk for psychosis and 16 healthy controls, and their relation to cortical thinning on Heschl's gyrus and planum temporale.
  
  
  RESULTS
  The auditory evoked M100 dipole moment was decreased in the ultra-high-risk subjects and in the patients with schizophrenia. Ultra-high-risk subjects showed impaired right M100 dipole magnitude, similar to patients with schizophrenia. Robust correlations between the cortical thickness of left Heschl's gyrus and the left M100 dipole moment were found in patients with schizophrenia. Moreover, correlations were also evident between right Heschl's gyrus and right M100 in subjects at ultra-high-risk for psychosis.
  
  
  CONCLUSIONS
  The primary feature of auditory perception in ultra-high-risk subjects and schizophrenia patients is an encoding deficit that manifests as a reduced M100 dipole moment. The relationship between abnormal M100, thinning of cortical generators and their symptomatology were shown to exist prior to the onset of overt psychosis and progressively worsen over time. Therefore, they may be a potential indicator of the development of schizophrenia.
authors: Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, Republic of Korea.
authors: Kyung Soon
authors: KS
authors: Shin
authors: Wi Hoon
authors: WH
authors: Jung
authors: June Sic
authors: JS
authors: Kim
authors: Joon Hwan
authors: JH
authors: Jang
authors: Jae Yeon
authors: JY
authors: Hwang
authors: Chun Kee
authors: CK
authors: Chung
authors: Jun Soo
authors: JS
authors: Kwon
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001308:Auditory Perceptual Disorders / Q000175:diagnosis / Q000209:etiology*; D002540:Cerebral Cortex / Q000473:pathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D011569:Psychiatric Status Rating Scales; D012306:Risk; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*; D055815:Young Adult