title: Analysis of selected anticonvulsants by high performance liquid chromatography-tandem mass spectrometry.
abstract: A method for the analysis of the basic antiepileptic compounds felbamate, lamotrigine, carbamazepine, carbamazepine-10,11-epoxide, gabapentin, pregabalin, levetiracetam, and oxcarbazepine monohydroxy derivative (oxcarb MHD) in human plasma is described. This protocol incorporates a simplified sample preparation step followed by quantitative high performance chromatography-tandem mass spectrometry detection of commonly prescribed and monitored anticonvulsant drugs. Since polytherapy is common in epilepsy patients, use of a multiconstituent assay can improve laboratory efficiency and reduce required analytical time.
authors: Forensic Laboratory, MEDTOX Laboratories, Inc, St. Paul, MN, USA. jcollins@medtox.com
authors: Jennifer A
authors: JA
authors: Collins
authors: Gregory C
authors: GC
authors: Janis
mesh_terms: D000927:Anticonvulsants / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D053719:Tandem Mass Spectrometry
chemical_list: D000927:Anticonvulsants