title: Multiple Loci are associated with dilated cardiomyopathy in Irish wolfhounds.
abstract: Dilated cardiomyopathy (DCM) is a highly prevalent and often lethal disease in Irish wolfhounds. Complex segregation analysis indicated different loci involved in pathogenesis. Linear fixed and mixed models were used for the genome-wide association study. Using 106 DCM cases and 84 controls we identified one SNP significantly associated with DCM on CFA37 and five SNPs suggestively associated with DCM on CFA1, 10, 15, 21 and 17. On CFA37 MOGAT1 and ACSL3 two enzymes of the lipid metabolism were located near the identified SNP.
authors: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany. ute.philipp@tiho-hannover.de
authors: Ute
authors: U
authors: Philipp
authors: Andrea
authors: A
authors: Vollmar
authors: Jens
authors: J
authors: Häggström
authors: Anne
authors: A
authors: Thomas
authors: Ottmar
authors: O
authors: Distl
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000235:genetics* / Q000662:veterinary; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D008297:Male; D015233:Models, Statistical; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D004247:DNA