title: Guided bone regeneration using cyanoacrylate-combined calcium phosphate in a dehiscence defect: a histologic study in dogs.
abstract: OBJECTIVE
  This study evaluated the effects of cyanoacrylate-combined calcium phosphate (CCP) as a candidate for a barrier membrane substitute in guided bone regeneration and the space maintenance capability of CCP placed in a dehiscence defect model.
  
  
  METHODS
  Six standardized dehiscence defects (5 × 3 mm, height × width) around dental implants were created on unilateral edentulous ridges in 5 dogs, where each defect was treated with sham surgery, biphasic calcium phosphate (BCP), CCP, barrier membrane (MEM), BCP + MEM, and CCP + MEM. The animals were sacrificed after an 8-week healing interval for histologic and histometric analyses.
  
  
  RESULTS
  The BCP and CCP sites showed increased bone formation compared with the control sites, although incomplete defect resolution occurred; bone regeneration heights (area) averaged 3.52 ± 0.69 mm (4.94 ± 2.59 mm(2)), 3.51 ± 0.16 mm (4.10 ± 1.99 mm(2)), and 1.53 ± 0.42 mm (1.01 ± 0.74 mm(2)) for the BCP, CCP, and control sites, respectively. All the MEM sites showed more bone formation compared with the sites that received the same biomaterials without a MEM, and the BCP + MEM and CCP + MEM sites showed extensive bone formation within the defect and on top of the implant; the bone regeneration heights (area) averaged 3.96 ± 2.86 mm (12.46 ± 11.61 mm(2)), 5.45 ± 0.25 mm (11.63 ± 1.97 mm(2)), and 2.62 ± 0.27 mm (3.43 ± 0.98 mm(2)) for the BCP + MEM, CCP + MEM, and MEM sites, respectively.
  
  
  CONCLUSIONS
  CCP can be a good scaffold for supporting an MEM as opposed to acting as a substitute for the MEM in guided bone regeneration.
authors: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors: Jung-Seok
authors: JS
authors: Lee
authors: Seung-Hee
authors: SH
authors: Ko
authors: Young-Taek
authors: YT
authors: Kim
authors: Ui-Won
authors: UW
authors: Jung
authors: Seong-Ho
authors: SH
authors: Choi
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000737:chemistry*; D003487:Cyanoacrylates / Q000737:chemistry*; D015921:Dental Implants; D004195:Disease Models, Animal; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006882:Hydroxyapatites / Q000627:therapeutic use; D007575:Jaw, Edentulous / Q000473:pathology / Q000601:surgery; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D011138:Polytetrafluoroethylene; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003487:Cyanoacrylates; D015921:Dental Implants; D006882:Hydroxyapatites; D008567:Membranes, Artificial; C074950:hydroxyapatite-beta tricalcium phosphate; D011138:Polytetrafluoroethylene; C020243:calcium phosphate