title: Novel C-9, 9'-O-acyl esters of (-)-carinol as free-radical scavengers and xanthine oxidase enzyme inhibitors: synthesis and biological evaluation.
abstract: New compounds with hydrophyllic esters of (-)-carinol were synthesized and evaluated as xanthine oxidase enzyme inhibitors and antioxidants. Aliphatic esterfication of C-9,9'-OH groups of (-)-carinol resulted in lowering antioxidant and xanthine oxidase inhibitory activities. However certain aromatic acyl esters considerably improved the xathine oxidase inhibition. Aromatic esterification with electron withdrawing substitutions would preferred for improvement in XOD inhibition while retaining radical scavenging activity, electron withdrawing substitution led to the loss of free radical scavenging property and neutral substituents decrease the enzyme inhibitory potential.
authors: St. Jude Children's Research Hospital, Department of Chemical Biology and Therapeutics, Memphis, TN-38105, USA. spk0102@gmail.com
authors: Praveen Kumar
authors: PK
authors: Suryadevara
authors: Hari Babu
authors: HB
authors: Tatipaka
authors: Rama Subba Rao
authors: RS
authors: Vidadala
authors: Ashok K
authors: AK
authors: Tiwari
authors: Janaswamy Madhusudana
authors: JM
authors: Rao
authors: Katragadda Suresh
authors: KS
authors: Babu
mesh_terms: D000215:Acylation; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D016166:Free Radical Scavengers; D017705:Lignans; D014969:Xanthine Oxidase