title: Specific expression of human intelectin-1 in malignant pleural mesothelioma and gastrointestinal goblet cells.
abstract: Malignant pleural mesothelioma (MPM) is a fatal tumor. It is often hard to discriminate MPM from metastatic tumors of other types because currently, there are no reliable immunopathological markers for MPM. MPM is differentially diagnosed by some immunohistochemical tests on pathology specimens. In the present study, we investigated the expression of intelectin-1, a new mesothelioma marker, in normal tissues in the whole body and in many cancers, including MPM, by immunohistochemical analysis. We found that in normal tissues, human intelectin-1 was mainly secreted from gastrointestinal goblet cells along with mucus into the intestinal lumen, and it was also expressed, to a lesser extent, in mesothelial cells and urinary epithelial cells. Eighty-eight percent of epithelioid-type MPMs expressed intelectin-1, whereas sarcomatoid-type MPMs, biphasic MPMs, and poorly differentiated MPMs were rarely positive for intelectin-1. Intelectin-1 was not expressed in other cancers, except in mucus-producing adenocarcinoma. These results suggest that intelectin-1 is a better marker for epithelioid-type MPM than other mesothelioma markers because of its specificity and the simplicity of pathological assessment. Pleural intelectin-1 could be a useful diagnostic marker for MPM with applications in histopathological identification of MPM.
authors: Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan.
authors: Kota
authors: K
authors: Washimi
authors: Tomoyuki
authors: T
authors: Yokose
authors: Makiko
authors: M
authors: Yamashita
authors: Taihei
authors: T
authors: Kageyama
authors: Katsuo
authors: K
authors: Suzuki
authors: Mitsuyo
authors: M
authors: Yoshihara
authors: Yohei
authors: Y
authors: Miyagi
authors: Hiroyuki
authors: H
authors: Hayashi
authors: Shoutaro
authors: S
authors: Tsuji
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D058851:GPI-Linked Proteins / Q000096:biosynthesis; D015972:Gene Expression Regulation, Neoplastic; D020397:Goblet Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D037102:Lectins / Q000096:biosynthesis*; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009928:Organ Specificity; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D009363:Neoplasm Proteins