title: Time course production of indole alkaloids by an endophytic strain of Penicillium brasilianum cultivated in rice.
abstract: During our studies concerning endophytic fungi, two indole alkaloids were co-produced with verruculogen by Penicillium brasilianum isolated from Melia azedarach (Meliaceae). The compounds were isolated by the use of combined chromatographic procedures and identified by physical methods, mainly 1D- and 2D-NMR experiments. This article also describes the production of verruculogen TR-2, first described for this species of Penicillium, and a verruculogen TR-2C-11 epimer, that is a novel fungal natural product. The kinetic production of verruculogen and verruculogen TR-2 produced by P. brasilianum were evaluated in order to understand the involvement of verruculogen TR-2 in verruculogen biosynthesis.
authors: Departamento de Química, Universidade Federal de São Carlos, CP 676, 13.565-905 São Carlos, São Paulo, Brazil. taicia@gmail.com
authors: Taicia Pacheco
authors: TP
authors: Fill
authors: Heloísa Briganti Rodrigues
authors: HB
authors: Asenha
authors: Anna Silvia
authors: AS
authors: Marques
authors: Antônio Gilberto
authors: AG
authors: Ferreira
authors: Edson
authors: E
authors: Rodrigues-Fo
mesh_terms: D002853:Chromatography, Liquid; D026121:Indole Alkaloids / Q000378:metabolism*; D007700:Kinetics; D012275:Oryza / Q000382:microbiology*; D010407:Penicillium / Q000378:metabolism*; D053719:Tandem Mass Spectrometry
chemical_list: D026121:Indole Alkaloids