title: Long-term glucose tolerance in highly experienced HIV-infected patients receiving nucleoside analogue-sparing regimens.
abstract: Thirty-nine HIV-1-infected patients treated for 156 weeks with a new nucleoside analogue-sparing regimen [raltegravir, etravirine and maraviroc (REM) or raltegravir, etravirine and darunavir/ritonavir (RED)] showed a uniform increase in fasting glucose levels and a uniform decrease in insulin secretory capacity. Diabetes mellitus occurred in one RED-treated and four REM-treated patients. A worsening glucose tolerance was observed in highly treatment-experienced HIV-infected patients receiving effective antiretroviral therapy after virological failure.
authors: Alba
authors: A
authors: Bigoloni
authors: Nicola
authors: N
authors: Gianotti
authors: Vincenzo
authors: V
authors: Spagnuolo
authors: Laura
authors: L
authors: Galli
authors: Silvia
authors: S
authors: Nozza
authors: Francesca
authors: F
authors: Cossarini
authors: Stefania
authors: S
authors: Salpietro
authors: Elisabetta
authors: E
authors: Carini
authors: Piermarco
authors: P
authors: Piatti
authors: Concetta
authors: C
authors: Vinci
authors: Adriano
authors: A
authors: Lazzarin
authors: Antonella
authors: A
authors: Castagna
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects*; D003510:Cyclohexanes / Q000494:pharmacology; D000069454:Darunavir; D005215:Fasting; D005951:Glucose Tolerance Test; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D006679:HIV Seropositivity / Q000097:blood* / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D000077592:Maraviroc; D009570:Nitriles; D011724:Pyridazines / Q000494:pharmacology; D011743:Pyrimidines; D011760:Pyrrolidinones / Q000494:pharmacology; D000068898:Raltegravir Potassium; D019438:Ritonavir / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D001786:Blood Glucose; D003510:Cyclohexanes; D017320:HIV Protease Inhibitors; D007328:Insulin; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D011760:Pyrrolidinones; D013449:Sulfonamides; D014230:Triazoles; C451734:etravirine; D000068898:Raltegravir Potassium; D000077592:Maraviroc; D019438:Ritonavir; D000069454:Darunavir