title: Presence of cobalt and chromium ions in the seminal fluid of young patients with metal-on-metal total hip arthroplasty.
abstract: We aimed to investigate the effect of metal ions on the semen of males of child fathering age with metal-on-metal (MM) total hip arthroplasty (THA). Semen was collected form 11 patients with MM THA and 5 control of comparable age. Cobalt and chromium concentrations were measured in both the seminal plasma and in the blood of patients. Results showed that cobalt level was higher in the seminal plasma of MM THA patients (2.89 μg/L) compared to control patients (1.12 μg/L) (P = .011). The ejaculate volume, the sperm density, the total sperm count, the pH, and the percentage of cells with normal morphology were in the range of the World Health Organization criteria for fertile population.
authors: Division of Orthopaedic Surgery, McGill University, 3755, Chemin de la Côte Ste-Catherine, Montréal, QC H3T 1E2, Canada.
authors: Vassilios S
authors: VS
authors: Nikolaou
authors: Alain
authors: A
authors: Petit
authors: David J
authors: DJ
authors: Zukor
authors: Constantine
authors: C
authors: Papanastasiou
authors: Olga L
authors: OL
authors: Huk
authors: John
authors: J
authors: Antoniou
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000032:analysis* / Q000097:blood; D003035:Cobalt / Q000032:analysis* / Q000097:blood; D006622:Hip Prosthesis; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013081:Sperm Motility
chemical_list: D002857:Chromium; D003035:Cobalt