title: Conjugated hyperbilirubinemia in children.
abstract: A variety of anatomic, infectious, autoimmune, and metabolic diseases can lead to conjugated hyperbilirubinemia, both in the newborn period and later in childhood. The pediatric practitioner is most likely to encounter conjugated hyperbilirubinemia in the neonatal period.It is crucial to maintain a high degree of suspicion for cholestasis in the persistently jaundiced newborn. The goal is recognition of conjugated hyperbilirubinemia between 2 and 4 weeks after birth, allowing for the prompt identification and management of infants who have biliary atresia, which remains the most common cause of neonatal cholestasis.
authors: Digestive Health Institute, Children's Hospital of Colorado, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
authors: David
authors: D
authors: Brumbaugh
authors: Cara
authors: C
authors: Mack
mesh_terms: D000293:Adolescent; D016738:Alagille Syndrome / Q000175:diagnosis; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis; D001656:Biliary Atresia / Q000175:diagnosis / Q000601:surgery; D001660:Biliary Tract Diseases / Q000175:diagnosis; D001663:Bilirubin / Q000097:blood; D002648:Child; D015529:Choledochal Cyst / Q000175:diagnosis; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis; D003937:Diagnosis, Differential; D042882:Gallstones / Q000175:diagnosis; D006506:Hepatitis A / Q000175:diagnosis; D006527:Hepatolenticular Degeneration / Q000175:diagnosis; D006801:Humans; D006932:Hyperbilirubinemia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008107:Liver Diseases / Q000175:diagnosis; D015997:Neonatal Screening
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin