title: Cytotoxic triterpenoids from Abies recurvata.
abstract: Nine triterpenoids (neoabiestrines A-I, 1-9) including six rearranged lanostanes (1-6) and a rare cycloart-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC(50) value of 17.8 μg/mL.
authors: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
authors: Yong-Li
authors: YL
authors: Li
authors: Yan-Xia
authors: YX
authors: Gao
authors: Xian-Wen
authors: XW
authors: Yang
authors: Hui-Zi
authors: HZ
authors: Jin
authors: Ji
authors: J
authors: Ye
authors: Luke
authors: L
authors: Simmons
authors: Ning
authors: N
authors: Wang
authors: Andre
authors: A
authors: Steinmetz
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C576729:neoabiestrine F