title: Patient self-assessment of hospital pain, mood and health-related quality of life in adults with sickle cell disease.
abstract: BACKGROUND
  Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.
  
  
  OBJECTIVE
  To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.
  
  
  METHODS
  Longitudinal study across three time-points.
  
  
  METHODS
  Secondary care, single specialist sickle cell centre.
  
  
  METHODS
  510 adult patients with SCD admitted to hospital daycare or inpatient units.
  
  
  METHODS
  Self-assessments of pain, mood and health-related quality of life with health utility (measured on the EQ-5D) on admission, before discharge and at 1-week postdischarge.
  
  
  RESULTS
  Mood, general health and quality of life showed significant steady improvements with reduction of pain in patients with SCD on admission to hospital, before discharge and at 1-week follow-up (p<0.01). Health utility scores derived from the EQ-5D showed a negative association with pain in regression analysis over the three time-points.
  
  
  CONCLUSIONS
  Examining health-related quality of life and health utility in relation to pain during hospital admissions is valuable in terms of targeting appropriate psychological interventions within the context of a multidisciplinary approach to managing sickle cell pain. This has implications for healthcare costs.
authors: Haematology and Sickle Cell Centre, Central Middlesex Hospital, London, UK.
authors: Kofi A
authors: KA
authors: Anie
authors: Hannah
authors: H
authors: Grocott
authors: Lauren
authors: L
authors: White
authors: Mendwas
authors: M
authors: Dzingina
authors: Gabriel
authors: G
authors: Rogers
authors: Gavin
authors: G
authors: Cho