title: Genome-wide linkage and association scans for pulse pressure in Chinese twins.
abstract: Elevated pulse pressure (PP) is associated with cardiovascular disorders and mortality in various populations. The genetic influence on PP has been confirmed by heritability estimates using related individuals. Recently, efforts have been made by mapping genes that are linked to the phenotype. We report the results of our gene mapping studies conducted in the Chinese population in mainland China. The genome-wide linkage and association scans were carried out on 63 middle-aged dizygotic twin pairs using high-density markers. The linkage analysis identified three significant linkage peaks (all with a single point P<1e(-05)) on chromosome 11 (LOD core 4.06 at 30.5 cM), chromosome 12 (LOD score 3.97 at 100.7 cM) and chromosome 18 (LOD score 4.01 at 70.7 cM), with the last two peaks closely overlapping with linkage peaks reported by two American studies. Multiple regions with suggestive linkages were identified, with many of the peaks overlapping with published linkage regions. The genome-wide association analysis detected a suggestive association on chromosome 4 (rs17031508, P<8.34e(-08)) located within a wide region of suggestive linkage. Our results provide some evidence for genetic linkages and associations with PP in the Chinese population. Further investigation is warranted to replicate the findings and to explore the susceptibility loci or genes for PP.
authors: Department of Public Health, Qingdao University Medical College, Qingdao, China. zhangdf1961@126.com
authors: Dongfeng
authors: D
authors: Zhang
authors: Zengchang
authors: Z
authors: Pang
authors: Shuxia
authors: S
authors: Li
authors: Wenjie
authors: W
authors: Jiang
authors: Shaojie
authors: S
authors: Wang
authors: Mads
authors: M
authors: Thomassen
authors: Jacob V B
authors: JV
authors: Hjelmborg
authors: Torben A
authors: TA
authors: Kruse
authors: Kirsten
authors: K
authors: Ohm Kyvik
authors: Kaare
authors: K
authors: Christensen
authors: Gu
authors: G
authors: Zhu
authors: Qihua
authors: Q
authors: Tan
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D002681:China; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014429:Twins, Dizygotic / Q000235:genetics*