title: Antihyperglycaemic and renoprotective effect of Boerhaavia diffusa L. in experimental diabetic rats.
abstract: The present study evaluates the efficacy of ethanolic extract of Boerhaavia diffusa L (BD) administered orally at a dose of 500mg/kg body weight for a period of 30 days to alloxanized diabetic rats and its efficacy compared with the standard hypoglycaemic drug metformin. Diabetic animals showed glycemic dysregulation, altered ionic balance, increased levels of serum markers of kidney function, and reduced Na+-K+ ATPase activity and endogenous antioxidant status. Administration of BD not only maintained the ionic balance and renal Na+-K+ ATPase activity but also significantly minimized diabetic hyperglycaemia. The renal antioxidant status (GPx, Catalase, SOD and GSH) remained in the near normal range and LPO level lower than the non-diabetic level. These effects are comparable to the changes brought about by metformin treatment and even better. Over all, the present study provides evidence for BD to be a potent renoprotective and antihyperglycaemic agent in diabetic animals.
authors: The MS University of Baroda.
authors: Prem Kumar
authors: PK
authors: Singh
authors: Darshee
authors: D
authors: Baxi
authors: Ankita
authors: A
authors: Doshi
authors: A V
authors: AV
authors: Ramachandran
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D000431:Ethanol; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D039281:Nyctaginaceae; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol; D000496:Alloxan