title: Cardiac rhythm disturbances associated with amlodipine acute intoxication.
abstract: Amlodipine is a dihydropyridine calcium channel antagonist extensively used for the treatment of arterial hypertension, with predominant effect on the peripheral vascular territory. In most cases of severe intoxication, important hypotension and reflex tachycardia are usually observed. We report a case of young man with severe amlodipine intoxication that developed important bradyarrhythmias, such as low atrial rhythm, prolonged PR interval, atrioventricular block, and left bundle branch block. These rhythm disturbances suggest that, during acute intoxication, dihydropyridine loses its selective action on the vascular territory and can depress automatism and conduction of cardiac electrical stimulus.
authors: Division of Emergency Medicine, Department of Internal Medicine, São Paulo University Medical School at Ribeirão Preto, Rua Bernardino de Campos, 1000, Ribeirão Preto, SP 14015-130, Brazil. chmirand@yahoo.com.br
authors: Carlos Henrique
authors: CH
authors: Miranda
authors: Leudo
authors: L
authors: Xavier
authors: Flávio
authors: F
authors: Fiorante
authors: Gustavo Prata
authors: GP
authors: Misiara
authors: Ellen Gonçalves
authors: EG
authors: Guimarães
authors: Ana Marta
authors: AM
authors: Galli
authors: Antônio
authors: A
authors: Pazin-Filho
authors: Marcos
authors: M
authors: de Carvalho Borges
mesh_terms: D000293:Adolescent; D017311:Amlodipine / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D017311:Amlodipine