title: Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings.
abstract: Cushing syndrome is associated with significant morbidity and mortality if left untreated because of associated metabolic and cardiovascular complications. An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment. His 4 month long medical treatment resulted in improvement of hypercotisolism clinically and biochemically and in complete disappearance of pituitary macro adenoma without any surgical intervention.
authors: Department of Medicine, The Aga Khan University Hospital, Karachi, Sindh, Pakistan. asma.ahmed@aku.edu
authors: Asma
authors: A
authors: Ahmed
authors: Saira
authors: S
authors: Furqan
authors: Najmul
authors: N
authors: Islam
mesh_terms: D058888:14-alpha Demethylase Inhibitors / Q000627:therapeutic use; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000077465:Cabergoline; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000627:therapeutic use*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D058888:14-alpha Demethylase Inhibitors; D000970:Antineoplastic Agents; D004873:Ergolines; D000077465:Cabergoline; D007654:Ketoconazole