title: An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome.
abstract: OBJECTIVE
  Experimental and epidemiological evidence shows a beneficial role of vitamin D in cancer. In vitro evidence is consistent with a similar protective function in glioma; however, no study has yet examined the potential role of vitamin D in glioma.
  
  
  METHODS
  We evaluated the association between common genetic variants in the vitamin D pathway and glioma risk and patient outcome in 622 newly diagnosed glioma cases and 628 healthy controls enrolled in a clinic-based case-control study. Subjects were genotyped for 7 candidate and tagging single nucleotide polymorphisms in the vitamin D receptor and 8 additional variants in NADSYN1, GC, CYP24A1, CYP2R1, and C10ORF88 linked in genome-wide association studies to serum concentrations of vitamin D. Unconditional logistic regression was used to estimate age- and gender-adjusted odds ratios and 95 % confidence intervals for glioma risk according to vitamin D genotypes. Proportional hazards regression was used to estimate hazard ratios for glioma-related death among 320 patients diagnosed with high-grade tumors. P values were uncorrected for multiple comparisons.
  
  
  RESULTS
  Risk of astrocytic tumors was associated with variant alleles in rs3829251 (NADSYN1), rs10741657 (CYP2R1), rs2228570 (Fok1, VDR), and rs731236 (Taq1, VDR). No risk associations were found among oligodendroglial tumors. Survival associations were observed according to variant status for rs1544410 (Bsm1, VDR) and rs6013897 (CYP24A1).
  
  
  CONCLUSIONS
  This exploratory analysis provides limited evidence of a role for genetic variation in vitamin D pathway genes with glioma risk and survival.
authors: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
authors: Gabriella M
authors: GM
authors: Anic
authors: Reid C
authors: RC
authors: Thompson
authors: L Burton
authors: LB
authors: Nabors
authors: L
authors: L
authors: Burton Nabors
authors: Jeffrey J
authors: JJ
authors: Olson
authors: James E
authors: JE
authors: Browning
authors: Melissa H
authors: MH
authors: Madden
authors: F Reed
authors: FR
authors: Murtagh
authors: F
authors: F
authors: Reed Murtagh
authors: Peter A
authors: PA
authors: Forsyth
authors: Kathleen M
authors: KM
authors: Egan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005910:Glioma / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D014807:Vitamin D / Q000235:genetics* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D