title: Diffuse sclerosing osteomyelitis of the mandible successfully treated with pamidronate: a long-term follow-up report.
abstract: Diffuse sclerosing osteomyelitis of the mandible (DSOM) is an uncommon chronic inflammatory disease of bone that is refractory to conventional treatments, such as antibiotics, nonsteroidal anti-inflammatory drugs, and decortication. We report a case of chronic DSOM of 15 years' duration in a 61-year-old woman that was successfully treated with a single infusion of pamidronate. Persistent, intractable pain resolved 3 days after infusion. Intense accumulation on (99m)Tc scintigraphy decreased 2 months after infusion, and almost disappeared after 3 years. Panoramic radiography demonstrated a clear decrease in pathologic changes, close to that of normal bone architecture, which has not been reported in DSOM treated with bisphosphonates.
authors: Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo, Japan. uradem@hyo-med.ac.jp
authors: Masahiro
authors: M
authors: Urade
authors: Kazuma
authors: K
authors: Noguchi
authors: Kazuki
authors: K
authors: Takaoka
authors: Kuniyasu
authors: K
authors: Moridera
authors: Hiromitsu
authors: H
authors: Kishimoto
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077268:Pamidronate; D011862:Radiography, Panoramic; D011877:Radionuclide Imaging; D012598:Sclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate