title: The effect of pulmonary blood flow changes on oxygen-enhanced lung magnetic resonance imaging.
abstract: In this study, we investigated the effects of changes in pulmonary blood flow on oxygen-enhanced lung magnetic resonance imaging. Increased pulmonary blood flow was produced by intravenous infusion of sildenafil (0.2 mg/kg) in 10 New Zealand white rabbits. Decreased pulmonary blood flow was produced by single subcutaneous injection of monocrotaline (60 mg/kg). A velocity-encoded cine magnetic resonance imaging for pulmonary blood flow and an oxygen-enhanced lung magnetic resonance imaging were performed at baseline, during sildenafil infusion, and after monocrotaline injection. We compared the baseline data to those obtained during sildenafil infusion and after monocrotaline injection for pulmonary blood flow changes and signal intensity enhancement ratios of oxygen-enhanced lung magnetic resonance imaging. Wilcoxon's signed rank test was used for statistical analysis. There was a significant difference between pulmonary blood flow at baseline (418.6±108.9 mL/min) and after sildenafil (491.9±118.0 mL/min; P=0.005) or between pulmonary blood flow at baseline and after monocrotaline administration (356.3±85.8 mL/min; P=0.017). However, there was no significant difference between the signal intensity enhancement ratios at baseline (23.8±11.4%) and after sildenafil (24.0±7.9%; P=0.953) or the signal intensity enhancement ratios at baseline and after monocrotaline administration (22.7±10.3%; P=0.374). Changes in pulmonary blood flow had little effect on the signal intensity enhancement ratio of oxygen-enhanced lung magnetic resonance imaging.
authors: Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University Health System, Seoul, Korea.
authors: Hye-Jeong
authors: HJ
authors: Lee
authors: Jaeseok
authors: J
authors: Park
authors: Jin
authors: J
authors: Hur
authors: Young Jin
authors: YJ
authors: Kim
authors: Ji Eun
authors: JE
authors: Nam
authors: Byoung Wook
authors: BW
authors: Choi
authors: Kyu Ok
authors: KO
authors: Choe
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D003287:Contrast Media / Q000008:administration & dosage; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood*; D011652:Pulmonary Circulation / Q000502:physiology*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D010100:Oxygen