title: Effects of PEG length and iron oxide nanoparticles size on reduced protein adsorption and non-specific uptake by macrophage cells.
abstract: At present, the studies showed that applications of magnetic iron oxide nanoparticels in vivo are hampered by their non-specific uptake by the innate immune system. And surface PEGylation of the nanoparticles maybe a feasible approach to escape from the reticular-endothelial system for a long blood circulation half-life. In this paper, we synthesized two sizes of monodisperse nanoparticles and studied the effects of PEG length on reduced protein adsorption and non-specific uptake by macrophage cells for an ideal material with a relatively long blood half-life. The results show that small nanoparticles with high molecular weight PEGylation may be a more applicable candidate due to their size effect and high efficiency in reducing protein adsorption.
authors: Department of Laboratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors: Fang
authors: F
authors: Ni
authors: Li
authors: L
authors: Jiang
authors: Ruixia
authors: R
authors: Yang
authors: Zhongping
authors: Z
authors: Chen
authors: Xu
authors: X
authors: Qi
authors: Jiwang
authors: J
authors: Wang
mesh_terms: D000327:Adsorption; D000818:Animals; D002460:Cell Line; D005290:Ferric Compounds / Q000737:chemistry*; D008264:Macrophages / Q000378:metabolism*; D053768:Metal Nanoparticles; D051379:Mice; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000378:metabolism*
chemical_list: D005290:Ferric Compounds; D011506:Proteins; C000499:ferric oxide; D011092:Polyethylene Glycols