title: A tumor growth inhibition model for low-grade glioma treated with chemotherapy or radiotherapy.
abstract: OBJECTIVE
  To develop a tumor growth inhibition model for adult diffuse low-grade gliomas (LGG) able to describe tumor size evolution in patients treated with chemotherapy or radiotherapy.
  
  
  METHODS
  Using longitudinal mean tumor diameter (MTD) data from 21 patients treated with first-line procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine (PCV) chemotherapy, we formulated a model consisting of a system of differential equations, incorporating tumor-specific and treatment-related parameters that reflect the response of proliferative and quiescent tumor tissue to treatment. The model was then applied to the analysis of longitudinal tumor size data in 24 patients treated with first-line temozolomide (TMZ) chemotherapy and in 25 patients treated with first-line radiotherapy.
  
  
  RESULTS
  The model successfully described the MTD dynamics of LGG before, during, and after PCV chemotherapy. Using the same model structure, we were also able to successfully describe the MTD dynamics in LGG patients treated with TMZ chemotherapy or radiotherapy. Tumor-specific parameters were found to be consistent across the three treatment modalities. The model is robust to sensitivity analysis, and preliminary results suggest that it can predict treatment response on the basis of pretreatment tumor size data.
  
  
  CONCLUSIONS
  Using MTD data, we propose a tumor growth inhibition model able to describe LGG tumor size evolution in patients treated with chemotherapy or radiotherapy. In the future, this model might be used to predict treatment efficacy in LGG patients and could constitute a rational tool to conceive more effective chemotherapy schedules.
authors: Ribba, INRIA, Project-team NUMED, Ecole Normale Superieure de Lyon, 46 allee d0Italie, 69007 Lyon Cedex 07, France. benjamin.ribba@inria.fr
authors: Benjamin
authors: B
authors: Ribba
authors: Gentian
authors: G
authors: Kaloshi
authors: Mathieu
authors: M
authors: Peyre
authors: Damien
authors: D
authors: Ricard
authors: Vincent
authors: V
authors: Calvez
authors: Michel
authors: M
authors: Tod
authors: Branka
authors: B
authors: Cajavec-Bernard
authors: Ahmed
authors: A
authors: Idbaih
authors: Dimitri
authors: D
authors: Psimaras
authors: Linda
authors: L
authors: Dainese
authors: Johan
authors: J
authors: Pallud
authors: Stéphanie
authors: S
authors: Cartalat-Carel
authors: Jean-Yves
authors: JY
authors: Delattre
authors: Jérôme
authors: J
authors: Honnorat
authors: Emmanuel
authors: E
authors: Grenier
authors: François
authors: F
authors: Ducray
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D008954:Models, Biological; D009367:Neoplasm Staging; D015203:Reproducibility of Results; D047368:Tumor Burden; D055815:Young Adult