title: Placental factor in spontaneous term labor in uncomplicated pregnancy.
abstract: OBJECTIVE
  To investigate the placental role in uncomplicated pregnancies and spontaneous term labor.
  
  
  METHODS
  Placentas were retrieved from women with uncomplicated pregnancies and compared between those with spontaneous term labor to those with elective cesarean delivery without labor. Placentas were analyzed for lesions consistent with maternal circulation abnormalities, lesions consistent with fetal thrombo-occlusive disease and inflammatory lesions, maternal or fetal responses.
  
  
  RESULTS
  The study included 139 pregnancies, 76 with term spontaneous deliveries (cases) and 63 with term elective cesarean deliveries (controls). Maternal age, gravidity, parity and BMI were significantly lower in the study group, but gestational age was higher as compared with the control group. Higher rate of maternal inflammatory lesions was observed in the study group compared to the control group, 21 vs. 1.6%, respectively, p = 0.001. No differences were observed in vascular lesions or in fetal inflammatory lesions between the groups.
  
  
  CONCLUSIONS
  Placental maternal inflammatory changes play a role in spontaneous term labor, different from the involvement of the fetal compartment and placental vascular component in preterm labor.
authors: Department of Obstetrics & Gynecology, The Edith Wolfson Medical Center, P.O. Box 5, Holon 58100, Israel.
authors: Jacob
authors: J
authors: Bar
authors: Letizia
authors: L
authors: Schreiber
authors: Abraham
authors: A
authors: Golan
authors: Michal
authors: M
authors: Kovo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D005260:Female; D006262:Health; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000502:physiology*; D010920:Placenta / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D011247:Pregnancy; D012422:Rupture, Spontaneous / Q000473:pathology; D047929:Term Birth / Q000502:physiology*; D055815:Young Adult