title: Septic disruption of lactiferous ducts with heterogeneous carcinoma of the breast in a lactating woman.
abstract: This report documents the diagnostic histopathological features of heterogeneous breast carcinoma following sepsis and disruption of the lactiferous ducts in a lactating woman and discusses the pathogenesis. Sections from the nipple revealed disrupted collecting lactiferous ducts presenting with intraduct precarcinoma and carcinoma of the epidermoid type, and attached reparative sprouts lined by lactiferous cells. Breast lobules showed generalised benign adenotic change with various foci of carcinoma microscopically identifiable as intraduct primitive lactiferal ectodermal carcinoma, lactating carcinoma, primitive neuroendocrine carcinoma and myoepithelioid granulomatous carcinoma. The findings led to the conclusion that the lactiferous ducts are susceptible to sepsis and disruption, which may predispose a patient to breast carcinoma. The pattern of carcinoma suggested that lactiferous epithelial cells behaved colonially, with different metaplastic changes, precarcinoma and carcinoma.
authors: Department of Pathology, JNMC AMU Aligarh, Aligarh, India. profmnaim@gmail.com
authors: Mohammed
authors: M
authors: Naim
authors: Vanesa T
authors: VT
authors: John
authors: Kavita
authors: K
authors: Gaur
authors: Afzal
authors: A
authors: Anees
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001942:Breast Feeding / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007775:Lactation Disorders / Q000209:etiology*; D042361:Mammary Glands, Human / Q000473:pathology*; D015412:Mastectomy, Segmental / Q000379:methods; D008413:Mastitis / Q000150:complications*; D009558:Nipples / Q000473:pathology; D011230:Precancerous Conditions / Q000150:complications / Q000473:pathology; D018570:Risk Assessment; D018805:Sepsis / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome