title: Difficult clinical challenges in haemophilia: international experiential perspectives.
abstract: Haemostasis management in people with haemophilia can present a range of challenges to physicians. Specific challenges that may be encountered relate to regimens for immune tolerance induction, use of central venous access devices, optimizing care of paediatric patients with inhibitors and improving outcomes in acquired haemophilia. There are also challenges related to performing surgery, and the establishment of specialist centres is valuable with regard to this. These challenges are considered in the light of available data, and with perspectives gained from the experience of experts treating patients around the world. Sharing this knowledge may help to improve patient management.
authors: RUSH Hemophilia and Thrombophilia Center, RUSH University Medical Center, Chicago, Illinois, USA.
authors: Angela L
authors: AL
authors: Forsyth
authors: Paul
authors: P
authors: Giangrande
authors: Charles R M
authors: CR
authors: Hay
authors: Gili
authors: G
authors: Kenet
authors: Craig M
authors: CM
authors: Kessler
authors: Paul N
authors: PN
authors: Knöbl
authors: Adolfo
authors: A
authors: Llinás
authors: Elena
authors: E
authors: Santagostino
authors: Guy
authors: G
authors: Young
mesh_terms: D019774:Blood Coagulation Factor Inhibitors / Q000097:blood; D055499:Catheter-Related Infections / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003029:Coagulants / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005169:Factor VIII / Q000008:administration & dosage* / Q000627:therapeutic use; D006395:Hemarthrosis / Q000517:prevention & control; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D013203:Staphylococcal Infections / Q000209:etiology; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D003029:Coagulants; D005169:Factor VIII