title: The zebrafish as a tool in leukemia research.
abstract: The zebrafish has proven to be a valuable vertebrate model in which to elucidate the molecular mechanisms of various diseases. A high degree of genetic and morphological similarity in hematopoiesis between the zebrafish and human indicates that zebrafish can provide valuable knowledge about the mechanisms behind pathogenesis of leukemia. To date, a small number of zebrafish leukemia models have been published and they have already provided some interesting information. However, the full potential of these models, especially the identification of contributing genetic factors and high-throughput drug screens, is yet to be fulfilled. Further transgenic or mutant animals are needed, especially for modeling high-risk leukemias, such as MLL rearranged infant leukemias.
authors: Paediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, 33520 Tampere, Finland.
authors: Kaisa J
authors: KJ
authors: Teittinen
authors: Toni
authors: T
authors: Grönroos
authors: Mataleena
authors: M
authors: Parikka
authors: Mika
authors: M
authors: Rämet
authors: Olli
authors: O
authors: Lohi
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D017690:Cell Transplantation / Q000379:methods; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012106:Research / Q000639:trends; D023041:Xenograft Model Antitumor Assays / Q000379:methods; D015027:Zebrafish / Q000235:genetics / Q000502:physiology*