title: A pathogenic non coding RNA that replicates and accumulates in chloroplasts traffics to this organelle through a nuclear-dependent step.
abstract: Viroids belonging to the family Avsunviroidae are the only functional RNAs known to traffic selectively into chloroplasts. Subcellular targeting is a critical step in guaranteeing their access to the machineries involved in their replication. However, the host mechanisms exploited by these non coding pathogenic RNAs to be selectively imported into chloroplasts are poorly understood. Recently, we provide evidence supporting the idea that the Avsunviroidae have evolved to subvert a signaling mechanism between the nucleus and chloroplasts to regulate their differential compartmentalization into the chloroplast of infected cells. Here, we discuss our model and previous observations that provide biological relevance to our hypothesis.
authors: Instituto de Biología Molecular y Celular de Plantas, CSIC-Universidad Politécnica de Valencia, CPI, Valencia, Spain.
authors: Gustavo
authors: G
authors: Gómez
authors: Vincente
authors: V
authors: Pallás
mesh_terms: D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism* / Q000821:virology; D002736:Chloroplasts / Q000378:metabolism* / Q000821:virology; D008954:Models, Biological; D010942:Plant Viruses / Q000235:genetics* / Q000502:physiology; D034443:RNA Transport; D022661:RNA, Untranslated / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
chemical_list: D022661:RNA, Untranslated