title: Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line.
abstract: Cytotrophoblasts are the key trophoblast cells which differentiate into different trophoblast lineages. In this report, glycodelin-A action on fusion of a cytotrophoblast-like cell line (BeWo) was investigated. It significantly reduced the spontaneous fusion of BeWo cells. The treatment enhanced the invasion and extracellular-signal regulated kinases activation of BeWo cells. The mRNA expression of syncytialization markers, human chorionic gonadotrophin and glial cells missing homolog 1 were suppressed upon glycodelin-A treatment. The data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation.
authors: Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong Special Administrative Region.
authors: K K W
authors: KK
authors: Lam
authors: R T K
authors: RT
authors: Pang
authors: C-L
authors: CL
authors: Lee
authors: H
authors: H
authors: Koistinen
authors: M
authors: M
authors: Seppala
authors: P-C
authors: PC
authors: Ho
authors: W S B
authors: WS
authors: Yeung
authors: P C N
authors: PC
authors: Chiu
mesh_terms: D002272:Carcinoembryonic Antigen / Q000235:genetics; D002454:Cell Differentiation / Q000502:physiology; D002459:Cell Fusion; D045744:Cell Line, Tumor; D002822:Choriocarcinoma; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000235:genetics; D004789:Enzyme Activation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000032:analysis / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D000071816:Glycodelin; D006023:Glycoproteins / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D011257:Pregnancy Proteins / Q000494:pharmacology* / Q000502:physiology; D014327:Trophoblasts / Q000187:drug effects / Q000502:physiology*
chemical_list: C075729:CEACAM3 protein, human; D002272:Carcinoembryonic Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D048049:Extracellular Signal-Regulated MAP Kinases