title: Global connectivity of prefrontal cortex predicts cognitive control and intelligence.
abstract: Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify a mechanism--global connectivity--by which components of this network might coordinate control of other networks. A lateral prefrontal cortex (LPFC) region's activity was found to predict performance in a high control demand working memory task and also to exhibit high global connectivity. Critically, global connectivity in this LPFC region, involving connections both within and outside the frontoparietal network, showed a highly selective relationship with individual differences in fluid intelligence. These findings suggest LPFC is a global hub with a brainwide influence that facilitates the ability to implement control processes central to human intelligence.
authors: Psychology Department, Washington University, St. Louis, Missouri 63130, USA. mwcole@mwcole.net
authors: Michael W
authors: MW
authors: Cole
authors: Tal
authors: T
authors: Yarkoni
authors: Grega
authors: G
authors: Repovs
authors: Alan
authors: A
authors: Anticevic
authors: Todd S
authors: TS
authors: Braver
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007206:Individuality; D007360:Intelligence / Q000502:physiology*; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen