title: [Antitumoral bibenzyl derivatives from tuber of Arundina graminifolia].
abstract: OBJECTIVE
  To isolate the bibenzyl derivatives from the tuber of Arundina graminifolia and evaluate the anti-tumor activity of these compounds in vitro.
  
  
  METHODS
  The constituents have been extracted by 95% alcohol and then isolated by column chromatography on silica gel and Sephedax LH-20. The structures were determined by UV, IR, NMR and MS spectral analysis.
  
  
  RESULTS
  Six constituents have been isolated, and their structures have been established as 2,7-dihydroxy-1-(p-hydroxylbenzyl)-4-methoxy-9, 10-dihydrophenanthrene (1), 4,7-dihydroxy-1- (p-hydroxylbenzyl)-2-methoxy-9,10-dihydrophenanthrene (2), 3, 3'-dihydroxy-5-methoxybibenzyl (3), (2E) -2- propenoic acid-3-(4-hydroxy-3-methoxyphenyl) -tetracosyl ester (4), (2E) -2-propenoic acid-3- (4-hydroxy-3- methoxyphenyl) -pentacosyl ester (5) and pentadecyl acid (6), respectively.
  
  
  CONCLUSIONS
  All compounds except for 3 were isolated from the tuber of A. graminifolia for the first time. Compound 3 with bibenzyl ring opening exhibits stronger anti-tumor activity than that of compounds 1 and 2 with bibenzyl ring closing.
authors: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. liumf@scut.edu.cn
authors: Meifeng
authors: M
authors: Liu
authors: Haoran
authors: H
authors: Lv
authors: Yi
authors: Y
authors: Ding
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry* / Q000276:immunology / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D029595:Orchidaceae / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001632:Bibenzyls; D004365:Drugs, Chinese Herbal