title: Evaluation of Pistacia lentiscus fatty oil effects on glycemic index, liver functions and kidney functions of New Zealand rabbits.
abstract: Pistacia lentiscus fatty oil (PLFO) is a well known natural remedy in eastern Algeria folk medicine. It is widely used in the treatment of respiratory disorders and dermal burns. The present study has been carried out to investigate effects of this oil on fasting glucose and some functional parameters of the liver and kidney in white male New Zealand rabbits (Initial mean weight 1.95 Kg). PLFO was applied to tested rabbits (PLFO group) via rectal route, once daily 5-day per week, for six consecutive weeks at the dose of 1 ml/Kg body weight. The same number of animals (n=6) was not treated and served as control (CRL group). The results showed that PLFO was tolerated by rectal route. No significant differences were observed in body weights of the two groups. Biochemical analysis showed that aspartate transaminase (AST) and alanine transaminase (ALT) were significantly decreased in blood plasma at (P< 0.05) and (P< 0.01) respectively in PLFO group (Mann-Whitney test). On the other hand, the fasting glucose level (GLU) was significantly increased (Mann-Whitney test, P< 0.05), while the rest of the tested parameters (Albumin, total proteins, creatinine, urea) was not significantly affected. However, these variations have not biologic signification toxicity. The study concludes that PLFO is tolerable via rectal route; it is safe with no adverse effect on liver functions and renal functions with possible anti-glycogenesis activity.
authors: Department of Veterinary Sciences, Pharmaco toxicology Laboratory, Mentouri Constantine University, Algeria. zouhir21265@yahoo.fr
authors: Zouhir
authors: Z
authors: Djerrou
authors: Y
authors: Y
authors: Hamdi-Pacha
authors: A M
authors: AM
authors: Belkhiri
authors: H
authors: H
authors: Djaalab
authors: F
authors: F
authors: Riachi
authors: M
authors: M
authors: Serakta
authors: A
authors: A
authors: Boukeloua
authors: Z
authors: Z
authors: Maameri
mesh_terms: D000285:Administration, Rectal; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D038321:Glycemic Index / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008111:Liver Function Tests; D008297:Male; D009520:New Zealand; D027927:Pistacia / Q000737:chemistry*; D010938:Plant Oils / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D010938:Plant Oils; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase