title: Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.
abstract: BACKGROUND
  Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population.
  
  
  METHODS
  A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model.
  
  
  RESULTS
  We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group.
  
  
  CONCLUSIONS
  Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.
authors: Department of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
authors: Nan
authors: N
authors: Zhao
authors: Xin
authors: X
authors: Liu
authors: Yongqin
authors: Y
authors: Wang
authors: Xiaoqiu
authors: X
authors: Liu
authors: Jiana
authors: J
authors: Li
authors: Litian
authors: L
authors: Yu
authors: Liyuan
authors: L
authors: Ma
authors: Shuyu
authors: S
authors: Wang
authors: Hongye
authors: H
authors: Zhang
authors: Lisheng
authors: L
authors: Liu
authors: Jingbo
authors: J
authors: Zhao
authors: Xingyu
authors: X
authors: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002545:Brain Ischemia / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000208:ethnology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000208:ethnology / Q000235:genetics*