title: Is there any relationship between decreased AgNOR protein synthesis and human hair loss?
abstract: Argyrophilic nucleolar organizing region associated proteins (AgNORs) play roles in cell proliferation and a variety of diseases. We attempted to determine whether decreased NOR protein synthesis causes human hair loss. We studied 21 healthy males who suffered hair loss on the frontal/vertex portion of the head. Hair root cells from normal and hair loss sites were stained for AgNOR. One hundred nuclei per site were evaluated and the AgNOR number and NORa/TNa proportions of individual cells were determined using a computer program. The cells from normal sites had significantly higher AgNOR counts than those from hair loss sites. Also, the cells from the normal sites had significantly higher NORa/TNa than cells from the hair loss sites. In the normal sites, the cells demonstrated more NOR protein synthesis than cells in hair loss sites. Therefore, decreased NOR protein synthesis appears to be related to hair loss in humans.
authors: Department of Medical Genetics, Duzce University Medical School, Duzce, Turkey. receperoz@duzce.edu.tr
authors: R
authors: R
authors: Eroz
authors: S
authors: S
authors: Tasdemir
authors: H
authors: H
authors: Dogan
mesh_terms: D000328:Adult; D000368:Aged; D000505:Alopecia / Q000378:metabolism*; D034961:Antigens, Nuclear / Q000032:analysis / Q000096:biosynthesis*; D006197:Hair / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000378:metabolism; D016622:Silver Staining; D055815:Young Adult
chemical_list: D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins