title: Changes in blood parameters and the expression of coagulation-related genes in lactating Sprague-Dawley rats.
abstract: This study measured blood parameters, particularly those related to coagulation, and alterations in the expression levels of blood-coagulation-related genes in lactating Sprague-Dawley rats. The day of delivery was designated as lactation day 0 (LD 0). On the day after delivery (LD 1), prothrombin time and overall activity of vitamin-K-dependent coagulation factors were decreased, whereas fibrinogen contents, platelet counts and antithrombin III concentrations were increased as compared with those in nonpregnant rats. In addition, hepatic expression of blood-coagulation-related genes in the liver was increased at LD 0 as compared with that in nonpregnant rats. These changes may be physiologic responses to prevent prolonged bleeding at delivery. Except for fibrinogen content, which remained elevated, the described changes returned to baseline on and after LD 7. Activities of AST, ALT, and ALP were increased on LD 7, 14, and 21 as compared with nonpregnant rats. In contrast, total protein, albumin, Cl, and Ca were consistently lower on LD 7, 14, or 21 as compared with levels in nonpregnant rats. These results provide background data for evaluation of nursing rats.
authors: Gotemba Laboratory, Bozo Research Center, Shizuoka, Japan. urasoko@hotmail.co.jp
authors: Yoshinaka
authors: Y
authors: Urasoko
authors: Xi Jun
authors: XJ
authors: He
authors: Takano
authors: T
authors: Masao
authors: Yuichi
authors: Y
authors: Kinoshita
authors: Hiroshi
authors: H
authors: Edamoto
authors: Kazuhisa
authors: K
authors: Hatayama
authors: Yuzo
authors: Y
authors: Asano
authors: Kazutoshi
authors: K
authors: Tamura
authors: Masahiro
authors: M
authors: Mochizuki
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D001777:Blood Coagulation; D005260:Female; D005786:Gene Expression Regulation; D007774:Lactation; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D013997:Time Factors