title: Role of tumor-associated macrophages and angiogenesis in desmoid-type fibromatosis.
abstract: Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor with fibroblastic features affecting two to four individuals per million population per year. Despite its bland microscopic appearance, the tumor behaves aggressively. Although unable to metastasize, DTF tends to recur and local recurrences in anatomically critical sites can be fatal. Tumor-associated macrophages (TAM) play an important role in tumor development through the activation of angiogenesis, particularly in cases of epithelial malignancies. The aim of this study is to investigate the prognostic significance of TAMs and the number of microvessels in DTF. Tumor macrophages (CD163), microvessel density (CD31), and beta-catenin were investigated on 69 primary DTF cases with follow-up information. CTNNB1 mutations were also studied. High density of tumor macrophages and high number of microvessels were associated with a significantly worse recurrence-free survival (P = 0.03 and P = 0.007, respectively). There was a significant correlation between microvessel density and CD163 macrophages (P = 0.02). Furthermore, combination of high number of tumor macrophages and high microvessel density greatly improved the statistical significance (P = 0.000005). Macrophages and microvessels may play an important role in the biologic behavior of DTF. This finding could help in the clinical management of patients with DTF.
authors: Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research, Autonomous University of Barcelona, Barcelona, Spain.
authors: Stefhanie
authors: S
authors: Romero
authors: Justyna
authors: J
authors: Szafranska
authors: Eliovel
authors: E
authors: Cabrera
authors: Allan
authors: A
authors: Gonzalez
authors: Ana
authors: A
authors: Peiró
authors: Jaume
authors: J
authors: Llauger
authors: Luis
authors: L
authors: Ortega
authors: Silvia
authors: S
authors: Bague
authors: Belén
authors: B
authors: Canet
authors: Inigo
authors: I
authors: Espinosa
authors: Jaime
authors: J
authors: Prat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D018222:Desmoid Tumors / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D046888:Tissue Array Analysis; D055815:Young Adult; D051176:beta Catenin / Q000235:genetics
chemical_list: C495270:CTNNB1 protein, human; D051176:beta Catenin