title: Postchallenge hyperglycemia is positively associated with diabetic polyneuropathy: the KORA F4 study.
abstract: OBJECTIVE
  To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes.
  
  
  METHODS
  Glucose tolerance status was determined in 61- to 82-year-old participants (n = 1,100) of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 Survey (2006-2008). Clinical DSPN was defined as bilaterally impaired foot-vibration perception and/or foot-pressure sensation.
  
  
  RESULTS
  Prevalence of clinical DSPN was similar in subjects with known diabetes (22.0%) and subjects with combined impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) (23.9%). Among prediabetic subgroups, IFG-IGT, but not isolated-IFG and -IGT, was associated with a higher risk of clinical DSPN, compared with normal glucose tolerance. A J-shaped association was observed between clinical DSPN and quartiles of 2-h postchallenge glucose, but not with fasting glucose and HbA(1c) levels.
  
  
  CONCLUSIONS
  Subjects with IFG-IGT and known diabetes had a similar prevalence of clinical DSPN. Elevated 2-h postload glucose levels appeared important for disease risk.
authors: Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors: Brenda W C
authors: BW
authors: Bongaerts
authors: Wolfgang
authors: W
authors: Rathmann
authors: Bernd
authors: B
authors: Kowall
authors: Christian
authors: C
authors: Herder
authors: Doris
authors: D
authors: Stöckl
authors: Christa
authors: C
authors: Meisinger
authors: Dan
authors: D
authors: Ziegler
mesh_terms: D003929:Diabetic Neuropathies / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology*; D008297:Male
chemical_list: D006442:Glycated Hemoglobin