title: Synthesis and in-vitro photodynamic studies of the superparamagnetic chitosan hydrogel/chlorin E6 nanocarriers.
abstract: The objective of the present study was to develop superparamagnetic chitosan(CS) � dextran sulfate(DS) hydrogels as a intelligent drug system for effective carrying of Chlorin E6(chn E6) photosensitizer to cancer cells. This system can be detectable by magnetic Resonance Imaging technique. The study shows that the lifetime of the triplet state for chn E6 photosensitizer is significantly increase when encapsulate into hydrogel. In addition to the possible enhancement of 1O2 generation, other advantages to incorporating chn E6 -based PS agents into hydrogel include the ability to solubilize these generally hydrophobic agents, the small and uniform size of hydrogels, and potential for passive targeting of solid tumors via the enhanced permeation and retention effect decreasing systemic photosensitization.
authors: Nanostructured Materials Synthesis Lab., International Research Institute of Arian Chemie Gostar, Tabriz, Iran.
authors: Mohammad Reza
authors: MR
authors: Saboktakin
authors: Roya M
authors: RM
authors: Tabatabaie
authors: Fahimeh Satarzade
authors: FS
authors: Amini
authors: Abel
authors: A
authors: Maharramov
authors: Mohammad Ali
authors: MA
authors: Ramazanov
mesh_terms: D002214:Capsules; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002735:Chlorophyllides; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D008027:Light; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D002214:Capsules; D002735:Chlorophyllides; D004337:Drug Carriers; D011166:Porphyrins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C062985:phytochlorin