title: Synthesis of enantioenriched triarylmethanes by stereospecific cross-coupling reactions.
abstract: Coupling with inversion: Chiral diarylmethanol derivatives undergo a stereospecific nickel-catalyzed cross-coupling reaction with aryl Grignard reagents (see scheme). The reaction proceeds with inversion of configuration and high enantiospecificity. The method has been applied to the asymmetric synthesis of a triarylmethane-based anti-cancer compound.
authors: Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
authors: Buck L H
authors: BL
authors: Taylor
authors: Michael R
authors: MR
authors: Harris
authors: Elizabeth R
authors: ER
authors: Jarvo
mesh_terms: D018360:Crystallography, X-Ray; D008697:Methane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D008697:Methane