title: [HLA-class I gene polymorphisms in Japanese Stevens-Johnson syndrome patients with ocular surface complications].
abstract: OBJECTIVE
  Our previous study of polymorphisms in the HLA-class I genes of 71 Japanese SJS/TEN patients with ocular surface complications and 113 Japanese healthy controls showed that in the Japanese, HLA-A*0206 was strongly associated with SJS/ TEN. In this study, we examined 118 Japanese SJS/ TEN patients with ocular surface complications and a new control group consisting of 220 healthy Japanese volunteers, and investigated the association between HLA class I antigens, HLA-A, B, C, and the SJS/ TEN.
  
  
  METHODS
  For HLA genotyping we enrolled 118 Japanese patients with SJS/TEN in the chronic or sub-acute phase at Kyoto Prefectural University of Medicine; all presented with ocular surface complications. We also enrolled 220 healthy Japanese volunteers. We performed polymerase chain reaction amplification followed by hybridization with sequence-specific oligonucleotide probes (PCR-SSO). Results : HLA-A*0206 was most strongly associated with Japanese SJS/TEN patients with ocular surface complications (carrier frequency: p = 0.0000000002, OR = 5.2; gene frequency : p = 0.000000007, OR = 4.2).
  
  
  CONCLUSIONS
  HLA-A* 0206 is strongly associated with Japanese SJS/TEN patients with ocular surface complications.
authors: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Shinnosuke
authors: S
authors: Nakaji
authors: Mayumi
authors: M
authors: Ueta
authors: Chie
authors: C
authors: Sotozono
authors: Tsutomu
authors: T
authors: Inatomi
authors: Shigeru
authors: S
authors: Kinoshita
mesh_terms: D044466:Asian People; D005128:Eye Diseases / Q000150:complications*; D005805:Genes, MHC Class I / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000235:genetics*