title: Periductal induction of high endothelial venule-like vessels in type 1 autoimmune pancreatitis.
abstract: OBJECTIVE
  Type 1 autoimmune pancreatitis (AIP) is histologically characterized by dense lymphoplasmacytic infiltration and marked storiform fibrosis, manifestations associated with pancreatic ducts. Such periductal lymphocyte recruitment is thought to be elicited by dysregulation of mechanisms governing physiological lymphocyte homing. The present study was undertaken to determine whether vascular addressins including peripheral lymph node addressin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) play a role in type 1 AIP histogenesis.
  
  
  METHODS
  Tissue sections of type 1 AIP and tumor-associated non-AIP chronic pancreatitis, as well as normal pancreas, were subjected to immunohistochemical analysis using vascular addressin-related antibodies.
  
  
  RESULTS
  The number of periductal mouse endothelial cell antigen 79-positive high endothelial venule (HEV)-like vessels was increased in type 1 AIP relative to that seen in non-AIP chronic pancreatitis, whereas the number of MAdCAM-1-positive HEV-like vessels did not differ between the 2 conditions. Mouse endothelial cell antigen 79 antigens are expressed on duct-forming epithelial cells not only in pancreas but also in salivary glands, which often harbor extrapancreatic lesions in type 1 AIP.
  
  
  CONCLUSIONS
  Type 1 AIP can be characterized by periductal induction of MECA-79-positive HEV-like vessels. MECA-79-positive 6-sulfo sialyl Lewis X-related carbohydrate antigens expressed on duct-forming epithelial cells could be associated with type 1 AIP pathogenesis.
authors: Department of Molecular Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
authors: Masafumi
authors: M
authors: Maruyama
authors: Motohiro
authors: M
authors: Kobayashi
authors: Yasuhiro
authors: Y
authors: Sakai
authors: Nobuyoshi
authors: N
authors: Hiraoka
authors: Ayumi
authors: A
authors: Ohya
authors: Shunsuke
authors: S
authors: Kageyama
authors: Eiji
authors: E
authors: Tanaka
authors: Jun
authors: J
authors: Nakayama
authors: Toshio
authors: T
authors: Morohoshi
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001327:Autoimmune Diseases / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D015815:Cell Adhesion Molecules; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D042601:Lymphatic Vessels / Q000737:chemistry / Q000473:pathology*; D008565:Membrane Proteins / Q000032:analysis; D009088:Mucoproteins / Q000032:analysis; D010183:Pancreatic Ducts / Q000737:chemistry / Q000473:pathology*; D010195:Pancreatitis / Q000378:metabolism / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D000954:Antigens, Surface; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D007074:Immunoglobulin G; D007136:Immunoglobulins; C069886:L-selectin counter-receptors; C504265:MADCAM1 protein, human; D008565:Membrane Proteins; D009088:Mucoproteins; D007633:Keratins