title: Left ventricular remodeling in patients with metabolic syndrome: influence of gender.
abstract: OBJECTIVE
  The study was aimed to evaluate the influence of gender on left ventricular (LV) remodeling in metabolic syndrome (MetS).
  
  
  RESULTS
  We enrolled 200 subjects without diabetes or overt cardiovascular diseases, never treated with anti-hypertensive drugs or statins: 60 men and 40 women with MetS matched by age, gender and 24 h systolic and diastolic blood pressure (BP) with 60 men and 40 women without MetS. The patients underwent blood tests, 24 h our BP monitoring, LV echocardiographic examination. LV mass indexed by eight(2.7) was significantly greater in men and women with MetS than without MetS. Compared with women without MetS, women with MetS had significantly higher posterior wall thickness and relative wall thickness, greater prevalence of LV concentric remodeling/hypertrophy and lower indices of LV diastolic function, whereas all these parameters were not significantly different between men with and without MetS. MetS was an independent predictor of relative wall thickness and LV mass index in women, but not in men.
  
  
  CONCLUSIONS
  The impact of MetS on LV remodeling is significantly influenced by gender: the effects of MetS are more pronounced in women, with development of LV concentric hypertrophy/remodeling and preclinical diastolic dysfunction.
authors: Ospedale di Circolo-Fondazione Macchi, Varese, Italy. elonikolini@libero.it
authors: E
authors: E
authors: Nicolini
authors: G
authors: G
authors: Martegani
authors: A M
authors: AM
authors: Maresca
authors: C
authors: C
authors: Marchesi
authors: F
authors: F
authors: Dentali
authors: A
authors: A
authors: Lazzarini
authors: S
authors: S
authors: Speroni
authors: L
authors: L
authors: Guasti
authors: A
authors: A
authors: Bertolini
authors: A
authors: A
authors: Venco
authors: A M
authors: AM
authors: Grandi
mesh_terms: D000328:Adult; D000886:Anthropometry; D001794:Blood Pressure; D016022:Case-Control Studies; D003920:Diabetes Mellitus; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D015995:Prevalence; D012737:Sex Factors; D016277:Ventricular Function, Left / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*