title: Magnetic resonance imaging of solitary brain metastases: main findings of nonmorphological sequences.
abstract: OBJECTIVE
  This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases.
  
  
  METHODS
  Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr. The nonmorphological parameters were compared with those from the literature for brain lesions that frequently enter the differential diagnosis with metastases.
  
  
  RESULTS
  Signal intensity and contrast enhancement patterns were variable. There was a wide range of ADC values: min:max 0.59×10(-3):1.88×10(-3). Compared with normal white matter, rCBV was higher in lesions (3.30±1.59) and lower in perilesional oedema (0.42±0.15). Mean and minimum PSR were 57% and 48%, respectively; lip and Cho were elevated and NAA reduced.
  
  
  CONCLUSIONS
  Conventional MR findings of solitary metastases are heterogeneous, and some values of nonmorphological sequences are similar to those of other brain lesions. PWI seems to be the nonmorphological MR technique that may best contribute to the diagnosis of brain metastases.
authors: Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy.
authors: S
authors: S
authors: Gaudino
authors: G M
authors: GM
authors: Di Lella
authors: R
authors: R
authors: Russo
authors: V S
authors: VS
authors: Lo Russo
authors: F
authors: F
authors: Piludu
authors: F R
authors: FR
authors: Quaglio
authors: M R
authors: MR
authors: Gualano
authors: C
authors: C
authors: De Waure
authors: C
authors: C
authors: Colosimo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001810:Blood Volume; D001932:Brain Neoplasms / Q000556:secondary*; D002648:Child; D002794:Choline / Q000378:metabolism; D003287:Contrast Media; D003401:Creatine / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D008055:Lipids; D009942:Organometallic Compounds; C064572:gadobenic acid; D001224:Aspartic Acid; D008536:Meglumine; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline