title: Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.
abstract: The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
authors: Viral Immune Evasion and Pathogenicity Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia.
authors: L
authors: L
authors: Wiltzer
authors: F
authors: F
authors: Larrous
authors: S
authors: S
authors: Oksayan
authors: N
authors: N
authors: Ito
authors: G A
authors: GA
authors: Marsh
authors: L F
authors: LF
authors: Wang
authors: D
authors: D
authors: Blondel
authors: H
authors: H
authors: Bourhy
authors: D A
authors: DA
authors: Jans
authors: G W
authors: GW
authors: Moseley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000378:metabolism; D018114:Lyssavirus / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D008969:Molecular Sequence Data; D011820:Rabies virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D050791:STAT Transcription Factors / Q000276:immunology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000276:immunology; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D007370:Interferon Type I; D050791:STAT Transcription Factors; D014764:Viral Proteins