title: Relieving the pruritus of atopic dermatitis: a meta-analysis.
abstract: The goal of this study was to perform a meta-analysis on randomized controlled trials of topical therapies compared against their vehicles, and systemic therapies compared against their placebos, and to record how these therapies changed the magnitude of pruritus associated with atopic dermatitis. A systematic search of the literature was performed using Medline, Embase, and the Cochrane Controlled Clinical Trials Register, as well as follow-up references in retrieved articles. Data regarding the magnitude of the change in pruritus was extracted from eligible publications and categorized according to the type of treatment modality. Standard inverse variance fixed-effects meta-analysis was used to calculate the pooled estimates for randomized controlled trials falling under each type of treatment. Overall, the topical treatments were more successful at reducing atopic pruritus compared to the systemic treatments. Calcineurin inhibitors were the most effective antipruritic agent.
authors: Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors: Lindsay G
authors: LG
authors: Sher
authors: Jongwha
authors: J
authors: Chang
authors: Isha B
authors: IB
authors: Patel
authors: Rajesh
authors: R
authors: Balkrishnan
authors: Alan B
authors: AB
authors: Fleischer
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000982:Antipruritics / Q000008:administration & dosage / Q000627:therapeutic use*; D065095:Calcineurin Inhibitors; D003876:Dermatitis, Atopic / Q000150:complications / Q000188:drug therapy*; D004333:Drug Administration Routes; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000982:Antipruritics; D065095:Calcineurin Inhibitors; D006633:Histamine Antagonists; D007166:Immunosuppressive Agents