title: The association between Chiari-like malformation, ventriculomegaly and seizures in cavalier King Charles spaniels.
abstract: Cavalier King Charles spaniels (CKCSs) with Chiari-like malformation (CM) and associated seizures are frequently diagnosed with idiopathic epilepsy. There could be an association between ventriculomegaly (V) or caudal fossa overcrowding (CCFP) and seizures. A retrospective case-control study was performed using MRI to investigate the possible association between these morphological abnormalities and seizures. Seizure semiology and, where possible, electroencephalographic (EEG) abnormalities were documented. Eighty-five CKCS with CM were included, 27 with seizures. There was no association between V or CCFP and seizures (P=0.10 and 0.71, respectively). Seizures were classified as having partial onset in 61% of individuals in the study population (95% CI 42.41-76.43%). Another cause of recurrent seizures in CKCS (such as familial epilepsy) is suspected, as previously reported.
authors: Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Potters Bar, Herts AL9 7TA, UK. cdriver@rvc.ac.uk
authors: C J
authors: CJ
authors: Driver
authors: K
authors: K
authors: Chandler
authors: G
authors: G
authors: Walmsley
authors: N
authors: N
authors: Shihab
authors: H A
authors: HA
authors: Volk
mesh_terms: D000818:Animals; D001139:Arnold-Chiari Malformation / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D006849:Hydrocephalus / Q000209:etiology / Q000662:veterinary*; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology / Q000662:veterinary*