title: A model for the structure of satellite tobacco mosaic virus.
abstract: Satellite tobacco mosaic virus (STMV) is an icosahedral T=1 single-stranded RNA virus with a genome containing 1058 nucleotides. X-ray crystallography revealed a structure containing 30 double-helical RNA segments, with each helix having nine base pairs and an unpaired nucleotide at the 3' end of each strand. Based on this structure, Larson and McPherson proposed a model of 30 hairpin-loop elements occupying the edges of the icosahedron and connected by single-stranded regions. More recently, Schroeder et al. have combined the results of chemical probing with a novel helix searching algorithm to propose a specific secondary structure for the STMV genome, compatible with the Larson-McPherson model. Here we report an all-atom model of STMV, using the complete protein and RNA sequences and the Schroeder RNA secondary structure. As far as we know, this is the first all-atom model for the complete structure of any virus (100% of the atoms) using the natural genomic sequence.
authors: School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
authors: Yingying
authors: Y
authors: Zeng
authors: Steven B
authors: SB
authors: Larson
authors: Christine E
authors: CE
authors: Heitsch
authors: Alexander
authors: A
authors: McPherson
authors: Stephen C
authors: SC
authors: Harvey
mesh_terms: D002213:Capsid / Q000737:chemistry / Q000648:ultrastructure*; D018360:Crystallography, X-Ray; D055029:Inverted Repeat Sequences; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D020836:Protein Structure, Quaternary; D012367:RNA, Viral / Q000737:chemistry / Q000648:ultrastructure*; D019400:Tobacco mosaic satellite virus / Q000648:ultrastructure*
chemical_list: D012367:RNA, Viral