title: Fabrication of glutathione photoelectrochemical biosensor using graphene-CdS nanocomposites.
abstract: A novel glutathione (GSH) photoelectrochemical biosensor was fabricated using the newly synthesized graphene-CdS (GR-CdS) nanocomposites. The GR-CdS nanocomposites were prepared by a fast, one-step, aqueous reaction. The as-prepared GR-CdS structure inherited the excellent electron transport of GR and facilitated the spatial separation of photo-generated charge carrier, therefore resulting in the enhanced photocurrent, and making it a promising candidate for developing photoelectrochemical biosensors. The proposed GSH sensor displays satisfactory analytical performance with an acceptable linear range from 0.01 to 1.5 mmol L(-1) with a detection limit of 0.003 mmol L(-1) at a signal-to-noise ratio of 3, and also shows an excellent specificity against anticancer drugs and can be successfully applied for GSH detection in real samples. The as-synthesized GR-CdS nanocomposites exhibited obviously enhanced photovoltaic properties, which could be extended to the detection of other enzymes and biomolecules, thus providing a promising platform for the development of photoelectrochemical biosensors.
authors: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China.
authors: Xiaomei
authors: X
authors: Zhao
authors: Shiwei
authors: S
authors: Zhou
authors: Qingming
authors: Q
authors: Shen
authors: Li-Ping
authors: LP
authors: Jiang
authors: Jun-Jie
authors: JJ
authors: Zhu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D019187:Cadmium Compounds / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D005978:Glutathione / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000032:analysis / Q000737:chemistry; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013440:Sulfides / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D009883:Ophthalmic Solutions; D013440:Sulfides; C034939:cadmium sulfide; D006108:Graphite; D005978:Glutathione