title: Improved blood compatibility of polyethersulfone membrane with a hydrophilic and anionic surface.
abstract: In this study, a novel triblock copolymer of poly (styrene-co-acrylic acid)-b-poly (vinyl pyrrolidone)-b-poly(styrene-co-acrylic acid) (P(St-co-AA)-b-PVP-b-P(St-co-AA)) is synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and used for the modification of blood contacting surface of polyethersulfone (PES) membrane to improve blood compatibility. The synthesized block copolymer can be directly blended with PES to prepare PES membranes by a liquid-liquid phase separation technique. The compositions and structure of the PES membranes are characterized by thermogravimetric analysis (TGA), ATR-FTIR, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM); the surface charge density of the modified PES membrane was measured by Zeta-potential; the blood compatibility of the PES membranes was assessed by detecting bovine serum albumin (BSA) and bovine serum fibrinogen (BFG) adsorption, platelet adhesion, activated partial thromboplastin time (APTT), platelet activation, and thrombin-antithrombin III (TAT) generation. The results indicated that the blood compatibility of the modified PES membrane was improved due to the membrane surface modification by blending the amphiphilic block copolymer and the surface segregation of the block copolymer.
authors: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.
authors: Shengqiang
authors: S
authors: Nie
authors: Jimin
authors: J
authors: Xue
authors: Yi
authors: Y
authors: Lu
authors: Yeqiu
authors: Y
authors: Liu
authors: Dongsheng
authors: D
authors: Wang
authors: Shudong
authors: S
authors: Sun
authors: Fen
authors: F
authors: Ran
authors: Changsheng
authors: C
authors: Zhao
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000494:pharmacology; D000327:Adsorption; D000328:Adult; D000818:Animals; D000990:Antithrombin III / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002417:Cattle; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008567:Membranes, Artificial; D010314:Partial Thromboplastin Time; D015539:Platelet Activation; D010973:Platelet Adhesiveness / Q000187:drug effects; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011205:Povidone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry; D055672:Static Electricity; D013450:Sulfones / Q000737:chemistry*; D013499:Surface Properties / Q000187:drug effects; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013917:Thrombin / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D011137:Polystyrenes; D013450:Sulfones; D013501:Surface-Active Agents; C576528:poly(styrene-co-acrylic acid)-b-poly(vinyl pyrrolidone)-b-poly(styrene-co-acrylic acid); C022840:polyether sulfone; D012710:Serum Albumin, Bovine; D000990:Antithrombin III; D005340:Fibrinogen; D013917:Thrombin; D011205:Povidone