title: AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
abstract: Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.
authors: Department of Physiology, University of California, San Francisco, San Francisco, CA 94158-2517, USA.
authors: Katherine A
authors: KA
authors: Cunningham
authors: Zhaolin
authors: Z
authors: Hua
authors: Supriya
authors: S
authors: Srinivasan
authors: Jason
authors: J
authors: Liu
authors: Brian H
authors: BH
authors: Lee
authors: Robert H
authors: RH
authors: Edwards
authors: Kaveh
authors: K
authors: Ashrafi
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000166:cytology / Q000201:enzymology* / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D002628:Chemoreceptor Cells / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005247:Feeding Behavior; D005769:Gastrointestinal Motility; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology; D010614:Pharynx / Q000294:innervation / Q000378:metabolism / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism; D059326:Serotonergic Neurons / Q000201:enzymology / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D055372:AMP-Activated Protein Kinases; D051792:Basic Helix-Loop-Helix Proteins; D029742:Caenorhabditis elegans Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D018698:Glutamic Acid; D017346:Protein Serine-Threonine Kinases; D011985:Receptors, Serotonin; D012701:Serotonin; C510541:AAK-2 protein, C elegans