title: Methotrexate sodium-associated UV reactivation in a patient with acute lymphoblastic leukemia.
abstract: UV reactivation is an uncommon reaction characterized by recurrent inflammation in areas of prior sunburn or UV exposure following the administration of a triggering drug. We report a case of UV reactivation following administration of intravenous methotrexate sodium (MTX) 4 days after prolonged sun exposure in a 9-year-old boy with relapsed acute lymphoblastic leukemia. Our patient's MTX-associated UV reactivation occurred despite the use of sunscreen and without prior sunburn or sun-induced erythema, which suggests that even subclinical sun damage can trigger MTX-associated UV reactivation. Therefore, patients must be strongly encouraged to utilize a 3-pronged approach to sun safety including sun avoidance, sun-protective clothing, and broad-spectrum sunscreen use, especially during the week before MTX therapy.
authors: Penn State College of Medicine, Hershey, Pennsylvania, USA.
authors: Jessica
authors: J
authors: Yankura
authors: Nicole
authors: N
authors: Saddic
authors: Christopher R
authors: CR
authors: Jones
authors: David R
authors: DR
authors: Adams
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D013473:Sunscreening Agents / Q000008:administration & dosage; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000964:Antimetabolites, Antineoplastic; D013473:Sunscreening Agents; D008727:Methotrexate