title: MiR-1246: a new link of the p53 family with cancer and Down syndrome.
abstract: Since the discovery of miRNAs, a number of miRNAs have been identified as p53's transcriptional targets. Most of them are involved in regulation of the known p53 functions, such as cell cycle, apoptosis and senescence. Our recent study revealed miR-1246 as a novel target of p53 and its analogs p63 and p73 to suppress the expression of DYRK1A and consequently activate NFAT, both of which are associated with Down syndrome and possibly with tumorigenesis. This finding suggests that miR-1246 might serve as a likely link of the p53 family with Down syndrome. Here, we provide some prospective views on the potential role of the p53 family in Down syndrome via miR-1246 and propose a new p53-miR-1246-DYRK1A-NFAT pathway in cancer.
authors: Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA.
authors: Jun-Ming
authors: JM
authors: Liao
authors: Xiang
authors: X
authors: Zhou
authors: Yu
authors: Y
authors: Zhang
authors: Hua
authors: H
authors: Lu
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D002869:Chromosome Aberrations; D004314:Down Syndrome / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D050778:NFATC Transcription Factors / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D000097603:Dyrk Kinases
chemical_list: D035683:MicroRNAs; D050778:NFATC Transcription Factors; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D016159:Tumor Suppressor Protein p53; D000097603:Dyrk Kinases