title: Quercetin liposome sensitizes colon carcinoma to thermotherapy and thermochemotherapy in mice models.
abstract: Thermotherapy and thermochemotherapy have been used in clinics to treat patients with malignant diseases, including colon cancer, and their efficacy has been well proved. Heat shock proteins (HSPs), especially Hsp70, play important roles in neutralizing their efficacy. It has been reported that quercetin can suppress cancer by inhibiting the intratumoral expression of Hsp70. This study was designed to investigate whether quercetin could enhance sensitivity to thermotherapy and thermochemotherapy. Soluble quercetin liposome was used in this study. The effects of quercetin were investigated in vitro and in mouse colon cancer models of subcutaneous tumor and peritoneal carcinomatosis. The results showed that quercetin liposome inhibited the upregulation of Hsp70 and enhanced apoptosis induced by hyperthermia and thermochemotherapy. Systemic administration of quercetin liposome can sensitize CT26 cells to thermotherapy and chemothermotherapy. This study suggests that quercetin liposome might be potentially applied for clinical cancer therapy.
authors: State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors: Bing
authors: B
authors: He
authors: Xin
authors: X
authors: Wang
authors: Hua-shan
authors: HS
authors: Shi
authors: Wen-jing
authors: WJ
authors: Xiao
authors: Jing
authors: J
authors: Zhang
authors: Bo
authors: B
authors: Mu
authors: Yong-qiu
authors: YQ
authors: Mao
authors: Wei
authors: W
authors: Wang
authors: Yong-sheng
authors: YS
authors: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D003131:Combined Modality Therapy; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006979:Hyperthermia, Induced / Q000379:methods*; D008081:Liposomes / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011794:Quercetin / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008081:Liposomes; D011794:Quercetin