title: Low-grade chondrosarcoma of long bones treated with intralesional curettage followed by application of phenol, ethanol, and bone-grafting.
abstract: BACKGROUND
  A common treatment of low-grade cartilaginous lesions of bone is intralesional curettage with local adjuvant therapy. Because of the wide variety of different diagnoses and treatments, there is still a lack of knowledge about the effectiveness of the use of phenol as local adjuvant therapy in patients with grade-I central chondrosarcoma of a long bone.
  
  
  METHODS
  A retrospective study was done to assess the clinical and oncological outcomes after intralesional curettage, application of phenol and ethanol, and bone-grafting in eighty-five patients treated between 1994 and 2005. Inclusion criteria were histologically proven grade-I central chondrosarcoma and location of the lesion in a long bone. The average age at surgery was 47.5 years (range, 15.6 to 72.3 years). The average duration of follow-up was 6.8 years (range, 0.2 to 14.1 years). Patients were evaluated periodically with conventional radiographs and gadolinium-enhanced magnetic resonance imaging (Gd-MRI) scans. When a lesion was suspected on the basis of the MRI, the patient underwent repeat intervention. Depending on the size of the recurrent lesion, biopsy followed by radiofrequency ablation (for lesions of <10 mm) or repeat curettage (for those of ≥10 mm) was performed.
  
  
  RESULTS
  Of the eighty-five patients, eleven underwent repeat surgery because a lesion was suspected on the basis of the Gd-MRI studies during follow-up. Of these eleven, five had a histologically proven local recurrence (a recurrence rate of 5.9% [95% confidence interval, 0.9% to 10.9%]), and all were grade-I chondrosarcomas. General complications consisted of one superficial infection, and two femoral fractures within six weeks after surgery.
  
  
  CONCLUSIONS
  This retrospective case series without controls has limitations, but the use of phenol as an adjuvant after intralesional curettage of low-grade chondrosarcoma of a long bone was safe and effective, with a recurrence rate of <6% at a mean of 6.8 years after treatment.
authors: Department of Orthopedics, Leiden University Medical Center, J11-70, P.O. Box 9600, 2300 RC Leiden, The Netherlands. shmverdegaal@hotmail.com
authors: Suzan H M
authors: SH
authors: Verdegaal
authors: Hugo F G
authors: HF
authors: Brouwers
authors: Erik W
authors: EW
authors: van Zwet
authors: Pancras C W
authors: PC
authors: Hogendoorn
authors: Antonie H M
authors: AH
authors: Taminiau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050280:Arm Bones / Q000473:pathology / Q000601:surgery; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002813:Chondrosarcoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003287:Contrast Media; D003475:Curettage / Q000379:methods*; D018572:Disease-Free Survival; D000431:Ethanol / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry; D015552:Injections, Intralesional; D007867:Leg Bones / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D018579:Patient Selection; D019800:Phenol / Q000627:therapeutic use*; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019800:Phenol; D000431:Ethanol; D005682:Gadolinium