title: Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography.
abstract: The goal of the research was analysis of the effect of collagen condition in formation of cross-polarized CP OCT images. We used of the CP OCT technique for studying collagen condition on an example of oral mucosa. Special histologic picrosirius red (PSR) staining of cheek mucosa specimens was used with subsequent assessing of the result of collagen staining in polarized light. High correlation (r = 0.692, p = 0.0001) between OCT signal standard deviation (SD) in cross-polarized images and brightness of PSR stained collagen fibers in cheek mucosa specimens was demonstrated in patients with inflammatory intestine and oral mucosa diseases. We have found that the OCT signal SD in cross-polarized images reflects two boundary conditions of collagen disorganization, namely, loss of fiber properties at active inflammation which attenuates the signal and fibrosis that occurs due to synthesis of a new remodeled collagen which amplifies the OCT signal.
authors: Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia. natalia.gladkova@gmail.com
authors: Natalia
authors: N
authors: Gladkova
authors: Elena
authors: E
authors: Kiseleva
authors: Natalia
authors: N
authors: Robakidze
authors: Irina
authors: I
authors: Balalaeva
authors: Maria
authors: M
authors: Karabut
authors: Ekaterina
authors: E
authors: Gubarkova
authors: Felix
authors: F
authors: Feldchtein
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
chemical_list: D003094:Collagen