title: Get on the exosome bus with ALIX.
abstract: Exosomes have a growing inventory of functions, but the mechanism of protein sorting into exosomes has been unclear. Now, a signal sequence first described in viral budding provides just such a cargo sorting mechanism, revealing closer-than-expected parallelism between exosome biogenesis and the ESCRT-dependent endolysosomal pathway.
authors: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. James.hurley@nih.gov
authors: James H
authors: JH
authors: Hurley
authors: Greg
authors: G
authors: Odorizzi
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D053667:Syndecans / Q000378:metabolism*; D053676:Syntenins / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; C117020:PDCD6IP protein, human; C492144:Pdcd6ip protein, mouse; D053667:Syndecans; D053676:Syntenins