title: Comparison of specificities between two interferon-gamma release assays in Japan.
abstract: We compared the specificities of two interferon-gamma release assays (IGRAs), T-SPOT®.TB (T-SPOT) and the QuantiFERON®-TB Gold In-Tube (QFT-GIT) assay, in strictly selected subjects with a low risk of tuberculosis (TB) infection in a Japanese population. Of 111 subjects  who were mostly bacille Calmette-Guérin vaccinated, one was positive using both assays and 110 were negative, using international cut-off values. Although several meta-analyses report that QFT-GIT has higher specificity than T-SPOT, our study demonstrates that the specificity of both  assays is equally high in a population with a truly low risk of TB infection.
authors: Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Tokyo, Japan. higuchi@jata.or.jp
authors: K
authors: K
authors: Higuchi
authors: Y
authors: Y
authors: Sekiya
authors: H
authors: H
authors: Igari
authors: A
authors: A
authors: Watanabe
authors: N
authors: N
authors: Harada
mesh_terms: D000328:Adult; D001500:BCG Vaccine / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D058501:Enzyme-Linked Immunospot Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D059425:Interferon-gamma Release Tests; D007564:Japan; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D001500:BCG Vaccine; D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma