title: [Nitric oxide acts as an excitatory neurotransmitter at hypoglossal motor nucleus].
abstract: OBJECTIVE
  The study is to observe the effect of nitric oxide (NO) donor and scavenger to the hypoglossal motor nucleus (HMN) activity and explore the underlying mechanism.
  
  
  METHODS
  Male adult anesthetized Wistar rats were anesthetized. The activity of genioglossus (GG), diaphragma, blood pressure (BP) and respiratory rate (RR) were recorded when constant microdialysis perfusion of artificial cerebrospinal fluid (ACSF) to HMN as control, followed with diethylamine NONOate sodium salt hydrate (DEA), a NO donor, and 2-(4-carboxyphenyl)-4,4,5,5-tetra-methylimidazoline-1-oxyl-3-oxide potassium salt (carboxy-PTIO), a NO scavenger.
  
  
  RESULTS
  Compared with ACSF, application of DEA and carboxy-PTIO at HMN increased and decreased the GG activity respectively and significantly (P<0.05), mainly respiratory-related activity. The tonic GG, diaphragma activity, BP and RR had not been affected statistically between 30-120 min when microdialysis perfusion of both DEA and carboxy-PTIO were delivered.
  
  
  CONCLUSIONS
  Acting as an excitatory neurotransmitter of HMN, NO may contribute to the patency of upper airway physiologically.
authors: Dept. of Otolaryngology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China.
authors: Haiying
authors: H
authors: Wu
authors: Hattie
authors: H
authors: Liu
authors: Richard L
authors: RL
authors: Horner
authors: Liu
authors: L
authors: Liu
mesh_terms: D000818:Animals; D003964:Diaphragm; D004576:Electromyography; D007002:Hypoglossal Nerve; D008297:Male; D017551:Microdialysis; D009046:Motor Neurons; D018377:Neurotransmitter Agents; D009569:Nitric Oxide; D051381:Rats; D017208:Rats, Wistar; D014059:Tongue
chemical_list: D018377:Neurotransmitter Agents; D009569:Nitric Oxide