title: Two malignant tumours in the anterior mediastinum positive for CD5.
abstract: To our knowledge, the simultaneous involvement of the anterior mediastinum by a thymic carcinoma and a B-cell chronic lymphocytic leukaemia has not been reported previously. The authors describe the case of a 62-year-old man, suffering from severe bronchitis. Chest x-ray and CT scan showed a mediastinal tumour, resected short-time after diagnosis. First, standard based histological examination revealed a thymic carcinoma admixed by a dense lymphatic infiltrate. Additional immunohistochemical staining for CD5-labelled epithelial thymic carcinoma cells as well as neoplastic B cells and led in combination with blood tests to confirm the diagnosis of the composite occurrence of a thymic carcinoma and a B-cell chronic lymphocytic leukaemia.
authors: Department of Cardiac Surgery, Medical University Innsbruck, Austria. Christina.M.Steger@i-med.ac.at
authors: C M
authors: CM
authors: Steger
authors: A
authors: A
authors: Morresi-Hauf
authors: J
authors: J
authors: Krugmann
authors: P
authors: P
authors: Schirmacher
authors: R J
authors: RJ
authors: Rieker
authors: G
authors: G
authors: Mechtersheimer
mesh_terms: D018956:CD5 Antigens / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D013902:Radiography, Thoracic; D013945:Thymoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D018956:CD5 Antigens