title: A protocol for an asymmetric synthesis of γ-amino acids.
abstract: A new and practical method for the asymmetric synthesis of γ-amino acids from β,γ-butenolides by an in situ esterification, condensation, and reduction in a one-pot procedure is described. This method is quite general for the preparation of both enantiomers of aryl or aliphatic γ-amino acids in high yields. These γ-amino-acid derivatives were also shown to be versatile synthetic intermediates for further transformations by their conversion to γ-lactams, δ-amino alcohols, and hydrolysis products in high yields with no racemization.
authors: Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA. reddylrajender@yahoo.com
authors: Leleti Rajender
authors: LR
authors: Reddy
authors: Kapa
authors: K
authors: Prasad
authors: Mahavir
authors: M
authors: Prashad
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; C004511:butenolide; D015107:4-Butyrolactone