title: [State of bone structures in children with acute leukemia, experiencing unfavorable factors from Chernobyl accident].
abstract: The authors present an assessment of bone structure condition in children with acute leukemia. The changes in the collagen molecule, amino acid composition of urine and proteins reparation processes were revealed. Calcium phosphate excretion in the patients urine were increased. The serum osteocalcin level and colony formation efficiency of bone marrow fibroblasts in acute leukemia patients are lower than in control group. In the initial period of the disease 32% of patients have disturbancies in their endocrine status. The bone structure violation is combined with unfavorable disease outcome. The effectiveness of the treatment and prevention steps in acute leukemia patients depends on the leukemic process stage.
authors: V H
authors: VH
authors: Bebeshko
authors: D A
authors: DA
authors: Bazyka
authors: K M
authors: KM
authors: Bruslova
authors: T T
authors: TT
authors: Volodina
authors: L O
authors: LO
authors: Liashenko
authors: L M
authors: LM
authors: Panchenko
authors: N M
authors: NM
authors: Tsvietkova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000596:Amino Acids / Q000097:blood / Q000652:urine; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects; D002130:Calcium Phosphates / Q000652:urine; D016022:Case-Control Studies; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D003114:Colony-Forming Units Assay; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000652:urine; D008297:Male; D009367:Neoplasm Staging; D015675:Osteocalcin / Q000652:urine; D011829:Radiation Dosage; D014455:Ukraine
chemical_list: D000596:Amino Acids; D002130:Calcium Phosphates; D015675:Osteocalcin; D003094:Collagen; C020243:calcium phosphate