title: Multiple active centers of multi-subunit RNA polymerases.
abstract: The active center of multi-subunit RNA polymerase consists of two modules, the Mg(2+) module, holding the catalytic Mg(2+) ion, and a module made of a flexible domain, the Trigger Loop. Uniquely, the TL module can be substituted by alternative modules, thus changing the catalytic properties of the active center.
authors: Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
authors: Yulia
authors: Y
authors: Yuzenkova
authors: Mohammad
authors: M
authors: Roghanian
authors: Nikolay
authors: N
authors: Zenkin
mesh_terms: D020134:Catalytic Domain; D002412:Cations / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000235:genetics* / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008958:Models, Molecular; D021122:Protein Subunits / Q000235:genetics* / Q000378:metabolism; D013824:Thermus / Q000235:genetics; D014157:Transcription Factors; D035602:Transcriptional Elongation Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002412:Cations; D029968:Escherichia coli Proteins; C079667:GreB protein, E coli; D021122:Protein Subunits; D014157:Transcription Factors; D035602:Transcriptional Elongation Factors; D012321:DNA-Directed RNA Polymerases; D008274:Magnesium