title: Bone mineral crystallisation kinetics.
abstract: The kinetics of bone apatite crystallisation are examined using a novel approach to obtain quantitative, direction dependence features such as growth rate and activation energy. X-ray diffraction was employed for analysis of bovine, porcine and 'anorganic' bone specimens. Apatite coherence length was utilised as the independent variable within a Johnson-Mehl-Avrami (JMA) model. A direction averaged crystallisation activation energy of 183 ± 8 kJ mol(-1) was observed for the three bone groups. The Johnson-Mehl-Avrami 'n' exponent decreased with increasing temperature for all bone groups, indicating that apatite crystallisation changes to a diffusion limited process at higher temperatures. The results revealed little evidence to support any organic component 'protective' effect, and, on the contrary indicated that the organic matrix promotes apatite crystallisation.
authors: Department of Engineering and Applied Science, Cranfield University, Shrivenham, Wiltshire, SN6 8LA, UK. c.greenwood@cranfield.ac.uk
authors: C
authors: C
authors: Greenwood
authors: K
authors: K
authors: Rogers
authors: S
authors: S
authors: Beckett
authors: J
authors: J
authors: Clement
mesh_terms: D000818:Animals; D001031:Apatites / Q000737:chemistry / Q000493:pharmacokinetics; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001842:Bone and Bones / Q000737:chemistry* / Q000378:metabolism; D002113:Calcification, Physiologic / Q000502:physiology*; D002152:Calorimetry, Differential Scanning; D002417:Cattle; D002484:Cementation / Q000379:methods; D003460:Crystallization; D007700:Kinetics; D013552:Swine; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D018786:Bone Substitutes