title: Primary cerebellar histiocytic sarcoma in a 17-month-old girl.
abstract: The authors report on a case of histiocytic sarcoma (HS) in a pediatric patient presenting with a solitary tumor in the cerebellum, with the aim of providing insight into primary HS in the CNS, which is especially rare. A 17-month-old Japanese girl presented with a 2-week history of progressive gait disturbance. Brain MRI revealed a 4.7 × 4.3 × 4.3-cm well-demarcated solitary mass in the right hemisphere of the cerebellum, initially suggestive of medulloblastoma, ependymoma, or anaplastic astrocytoma. On intraoperative inspection the cerebellar tumor showed intensive dural attachment and was subtotally removed. Histological and immunohistochemical findings were consistent with HS. The patient subsequently received chemotherapy, and her preoperative neurological symptoms improved. Primary HS in the CNS usually demonstrates an aggressive clinical course and is currently considered to have a poor prognosis. The possibility of this rare tumor should be included in the differential diagnosis of localized cerebellar tumors in the pediatric age group.
authors: Division of Pathology, Kanagawa Children's Medical Center, Yokohama, Japan. gomikiyoshi@yahoo.co.jp
authors: Kiyoshi
authors: K
authors: Gomi
authors: Mio
authors: M
authors: Tanaka
authors: Mariko
authors: M
authors: Yoshida
authors: Susumu
authors: S
authors: Ito
authors: Masaki
authors: M
authors: Sonoda
authors: Fuminori
authors: F
authors: Iwasaki
authors: Tetsu
authors: T
authors: Niwa
authors: Noriko
authors: N
authors: Aida
authors: Hisato
authors: H
authors: Kigasawa
authors: Yukichi
authors: Y
authors: Tanaka
mesh_terms: D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000601:surgery; D005260:Female; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007223:Infant