title: Microfluidic reactor geometries for radiolysis reduction in radiopharmaceuticals.
abstract: Autoradiolysis describes the degradation of radioactively labeled compounds due to the activity of the labeled compounds themselves. It scales with activity concentration and is of importance for high activity and microfluidic PET tracer synthesis. This study shows that microfluidic devices can be shaped to reduce autoradiolysis by geometric exclusion of positron interaction. A model is developed and confirmed by demonstrating in-capillary storage of non-stabilized [(18)F]FDG (2-[(18)F]Fluoro-2-deoxy-d-glucose) at max. 23 GBq/ml while maintaining >90% radiochemical purity over 14 h.
authors: GE Global Research, Germany. rensch@ge.com
authors: Christian
authors: C
authors: Rensch
authors: Bjoern
authors: B
authors: Waengler
authors: Andriy
authors: A
authors: Yaroshenko
authors: Victor
authors: V
authors: Samper
authors: Marko
authors: M
authors: Baller
authors: Nicole
authors: N
authors: Heumesser
authors: Johan
authors: J
authors: Ulin
authors: Stefan
authors: S
authors: Riese
authors: Gerald
authors: G
authors: Reischl
mesh_terms: D044085:Microfluidics / Q000295:instrumentation*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals