title: Biomarkers for early diagnosis of AKI in the ICU: ready for prime time use at the bedside?
abstract: Because of its still rising incidence and high mortality rate in intensive care unit (ICU) patients, early recognition of acute kidney injury (AKI) remains a critical issue. Surprisingly, effective biomarkers for early detection and hence appropriate and timely therapy of AKI have not yet entered the clinical arena. We performed a systematic search of the literature published between 1999 and 2011 on potential early biomarkers for acute renal failure/kidney injury in an at-risk adult and pediatric population following the Quorum Guidelines. Based on this review, recommendations for the clinical use of these biomarkers were proposed. In general, kidney biomarkers may aid to direct early aggressive treatment strategies for AKI thereby decreasing the associated high mortality. To date, however, sensitivity and specificity of individual biomarker assays are low and do not sustain their routine clinical use. "Kits" containing a combination of established biomarkers, in conjunction with measured glomerular filtration rate, may enhance diagnostic and prognostic accuracy in the future.
authors: Intensive Care Dept, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. Patrick.Honore@uzbrussel.be.
authors: Patrick M
authors: PM
authors: Honore
authors: Rita
authors: R
authors: Jacobs
authors: Olivier
authors: O
authors: Joannes-Boyau
authors: Lies
authors: L
authors: Verfaillie
authors: Jouke
authors: J
authors: De Regt
authors: Viola
authors: V
authors: Van Gorp
authors: Elisabeth
authors: E
authors: De Waele
authors: Willem
authors: W
authors: Boer
authors: Vincent
authors: V
authors: Collin
authors: Herbert D
authors: HD
authors: Spapen