title: Inflammation linking EMT and cancer stem cells.
abstract: Similar to actors changing costumes during a performance, cancer cells undergo many rapid changes during the process of tumor metastasis, including epithelial-mesenchymal transition (EMT), acquisition of cancer stem cells (CSCs) properties, and mesenchymal-epithelial transition (MET). Such changes allow the tumor to compete with the normal microenvironment to overcome anti-tumorigenic pressures. Then, once tissue homeostasis is lost, the altered microenvironment, like that accompanying inflammation, can itself become a potent tumor promoter. This review will discuss the changes that cancer cells undergo in converting from EMT to CSCs in an inflammation microenvironment, to understand the mechanisms behind invasion and metastasis and provide insights into prevention of metastasis.
authors: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No 14, Sec 3, Renminnan Road, Chengdu Sichuan 610041, People's Republic of China.
authors: Chenchen
authors: C
authors: Zhou
authors: Jeffrey
authors: J
authors: Liu
authors: Yaling
authors: Y
authors: Tang
authors: Xinhua
authors: X
authors: Liang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology*; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines