title: Taking a bite out of Wnts.
abstract: Proper control of intercellular communication through the Wnt signaling pathway is of critical importance for many aspects of biology, including head formation during vertebrate embryogenesis. A recent Cell paper describes the discovery of a novel protein, TIKI, which controls head size through a surprising new mechanism of Wnt antagonism.
authors: Department of Biochemistry, University of Washington, Seattle, WA 98103-7350, USA.
authors: Cortney M
authors: CM
authors: Bouldin
authors: David
authors: D
authors: Kimelman
mesh_terms: D000818:Animals; D006257:Head / Q000502:physiology; D045726:Metalloproteases / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D051153:Wnt Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D014981:Xenopus; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C574706:TRABD2A protein, Xenopus; D051153:Wnt Proteins; D029867:Xenopus Proteins; D045726:Metalloproteases