title: Effect of the interleukin-1β gene on dorsolateral prefrontal cortex function in schizophrenia: a genetic neuroimaging study.
abstract: BACKGROUND
  Genetic studies have found that the interleukin-1β gene (IL1B, 2q13) influences the risk for schizophrenia, but the underlying biological mechanisms of the association are still unclear. Investigation of the effects of genetic variability in this gene on brain function could provide more information about its role in the disorder.
  
  
  METHODS
  The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia. Forty-eight schizophrenia patients and 46 control subjects underwent functional magnetic resonance imaging while performing the n-back task.
  
  
  RESULTS
  In the pooled sample, genetic variability at this locus was associated with differential brain activation in a bilateral frontal region including the dorsolateral prefrontal cortex. There was also a significant diagnosis × genotype interaction effect in an overlapping frontal region: the IL1B polymorphism did not affect activation in the control subjects in this area, but the schizophrenia patients who were T carriers showed significantly higher activation than the CC homozygotes.
  
  
  CONCLUSIONS
  The findings support a role for IL1B variability in the dorsolateral prefrontal cortex dysfunction classically associated with schizophrenia.
authors: Unitat d'Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain. mar.fatjovilas@ub.edu
authors: Mar
authors: M
authors: Fatjó-Vilas
authors: Edith
authors: E
authors: Pomarol-Clotet
authors: Raymond
authors: R
authors: Salvador
authors: Gemma C
authors: GC
authors: Monté
authors: Jesús J
authors: JJ
authors: Gomar
authors: Salvador
authors: S
authors: Sarró
authors: Jordi
authors: J
authors: Ortiz-Gil
authors: Candibel
authors: C
authors: Aguirre
authors: Ramón
authors: R
authors: Landín-Romero
authors: Amalia
authors: A
authors: Guerrero-Pedraza
authors: Sergi
authors: S
authors: Papiol
authors: Josep
authors: J
authors: Blanch
authors: Peter J
authors: PJ
authors: McKenna
authors: Lourdes
authors: L
authors: Fañanás
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods / Q000523:psychology*; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000523:psychology; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D044465:White People / Q000235:genetics / Q000523:psychology
chemical_list: D053583:Interleukin-1beta