title: Oral local drug delivery and new perspectives in oral drug formulation.
abstract: Modern pharmaceutical science has provided us with a wide range of substances to be administered with a wide large variety of dosage forms. Local drug delivery systems have been used for a long time; in particular, for the local therapy of diseases affecting the oral cavity. Although these diseases are often extremely responsive to local therapy, the mouth often presents various difficulties in the application of topical compounds (owing to saliva and the mouth's different functions), resulting in a short retention time of dosage forms with a consequent low therapeutic efficacy. To resolve these limitations, research today concentrates on the development of bioadhesive formulations. This review focuses on the permeability features of oral mucosa, the rationale of oral local drug delivery, and new potential bioadhesive local delivery systems. Furthermore, the most promising mucoadhesive systems proposed to locally treat oral diseases are discussed.
authors: Department of Surgical and Oncological Disciplines, Section of Oral Medicine V. Margiotta, University of Palermo, Palermo, Italy.
authors: Carlo
authors: C
authors: Paderni
authors: Domenico
authors: D
authors: Compilato
authors: Libero Italo
authors: LI
authors: Giannola
authors: Giuseppina
authors: G
authors: Campisi
mesh_terms: D000269:Adhesives; D000278:Administration, Buccal; D058956:Administration, Mucosal; D000286:Administration, Sublingual; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism; D010539:Permeability; D053210:Pharmaceutical Preparations, Dental / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000269:Adhesives; D004304:Dosage Forms; D053210:Pharmaceutical Preparations, Dental