title: A simple Bayesian decision-theoretic design for dose-finding trials.
abstract: A flexible and simple Bayesian decision-theoretic design for dose-finding trials is proposed in this paper. In order to reduce the computational burden, we adopt a working model with conjugate priors, which is flexible to fit all monotonic dose-toxicity curves and produces analytic posterior distributions. We also discuss how to use a proper utility function to reflect the interest of the trial. Patients are allocated based on not only the utility function but also the chosen dose selection rule. The most popular dose selection rule is the one-step-look-ahead (OSLA), which selects the best-so-far dose. A more complicated rule, such as the two-step-look-ahead, is theoretically more efficient than the OSLA only when the required distributional assumptions are met, which is, however, often not the case in practice. We carried out extensive simulation studies to evaluate these two dose selection rules and found that OSLA was often more efficient than two-step-look-ahead under the proposed Bayesian structure. Moreover, our simulation results show that the proposed Bayesian method's performance is superior to several popular Bayesian methods and that the negative impact of prior misspecification can be managed in the design stage.
authors: Department of Statistics and Biostatistics, California State University at East Bay, Hayward, CA 94542, USA. kelly.fan@csueastbay.edu
authors: Shenghua Kelly
authors: SK
authors: Fan
authors: Ying
authors: Y
authors: Lu
authors: You-Gan
authors: YG
authors: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001499:Bayes Theorem; D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards; D003198:Computer Simulation; D003603:Cytotoxins / Q000008:administration & dosage / Q000493:pharmacokinetics; D003662:Decision Theory; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016015:Logistic Models; D020714:Maximum Tolerated Dose; D012043:Regression, Psychology; D012107:Research Design; D018709:Statistics, Nonparametric
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins