title: NAD(P)H oxidase p22(phox)  polymorphism and cardiovascular function in amateur runners.
abstract: OBJECTIVE
  NAD(P)H system represents the major source of superoxide production at cardiovascular (CV) level. It has several genetic variants: in particular, the C242T polymorphism of its p22(phox)  subunit is associated with a different oxidase activity, being the T allele related to a lower superoxide production. Although several authors investigated the protective effect of T allele in CV diseases, only few data are available on its functional role in physiological conditions. The aim of our study was to investigate the relationship between the p22(phox)  C242T polymorphism and CV function in amateur runners.
  
  
  METHODS
  Seventy-three male amateur runners were screened for CYBA polymorphism. CV analysis was performed by echocardiographic-Doppler examination and by PulsePen tonometer assessment.
  
  
  RESULTS
  The genetic subgroups (CC and CT/TT) did not differ for VM O(2max)  and cardiac dimension. Nevertheless, T carriers (n = 40) were characterized by a more efficient myocardial contraction and left ventricular (LV) filling, as evidenced by significant higher values of the midwall fractional shortening, systolic excursion of the tricuspid annular plane and of early/late diastolic wave velocities ratio and by a lower E wave deceleration time. Pulse wave velocity and augmentation index, parameters related to the arterial stiffness, were higher in CC subjects compared with CT/TT also when the analysis was adjusted for weight and diastolic pressure.
  
  
  CONCLUSIONS
  In amateur runners, CYBA variants may influence both systolic and diastolic function and arterial stiffness. We suppose that the lower oxidative activity that characterizes 242T subjects may positively influence the excitation-contraction and arterial-ventricular coupling mechanisms, thus leading to a more efficient CV function.
authors: Department of Neuroscience and Imaging, University of Chieti-Pescara, Chieti, Italy.
authors: S
authors: S
authors: Gallina
authors: S
authors: S
authors: Di Francescomarino
authors: M
authors: M
authors: Di Mauro
authors: P
authors: P
authors: Izzicupo
authors: E
authors: E
authors: D'Angelo
authors: M A
authors: MA
authors: D'Amico
authors: A
authors: A
authors: Pennelli
authors: F
authors: F
authors: Amicarelli
authors: A
authors: A
authors: Di Baldassarre
mesh_terms: D000328:Adult; D000483:Alleles; D001794:Blood Pressure; D015150:Echocardiography, Doppler; D005838:Genotype; D006339:Heart Rate; D006801:Humans; D008297:Male; D019255:NADPH Oxidases / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012420:Running / Q000502:physiology*
chemical_list: D019255:NADPH Oxidases