title: Impact of VEGF polymorphisms on the severity of peripheral artery disease in diabetic patients.
abstract: OBJECTIVE
  To determine the potential genotype vascular endothelial growth factor (VEGF) gene differences in diabetic patients with peripheral arterial disease (PAD), which might be associated with different stages of the vascular disease.
  
  
  METHODS
  A study was conducted with type 2 diabetic patients with PAD [n = 70; 32 intermittent claudication and 38 critical limb ischaemia (CLI)]. Genotyping of the VEGF gene insertion/deletion - 2549, - 2578 C/A and +405 G/C polymorphisms was done in both groups and correlated them with the severity of PAD. We compared serum VEGF levels in both groups.
  
  
  RESULTS
  There was a higher frequency of +405 CC and - 2578 CC genotypes in claudication group [(31.3% vs. 5.4%, p = 0.01) and (37.5% vs. 15.8%, p = 0.05), respectively]. The presence of +405 GG and - 2578 AA genotypes was more common among CLI patients [(57.8% vs. 37.5%, p = 0.01) and (42.1% vs. 18.8%, p = 0.05), respectively]. There were higher serum VEGF levels in patients with CLI (p = 0.029).
  
  
  CONCLUSIONS
  We found preliminary evidence regarding the association between VEGF polymorphisms and different stages of PAD in diabetic patients.
authors: Angiology and Vascular Surgery Department of Hospital Universitario de Getafe, Madrid, Spain. silbleik@yahoo.es
authors: Silvia
authors: S
authors: Bleda
authors: Joaquin
authors: J
authors: De Haro
authors: Cesar
authors: C
authors: Varela
authors: Leticia
authors: L
authors: Esparza
authors: Ignacio Lopez
authors: IL
authors: De Maturana
authors: Francisco
authors: F
authors: Acin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007383:Intermittent Claudication / Q000150:complications; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A