title: Role of CD44 in tumour progression and strategies for targeting.
abstract: CD44 or hyaluronan receptor is a transmembrane receptor associated with aggressive tumour growth, proliferation, and metastasis. In normal physiology, this receptor has a crucial role in cell adhesion, inflammation, and repair processes. However, many tumour cells over-express this receptor and abuse it to become progressive and perpetual units. The article comments from common functioning of the CD44 receptor, to its diabolic multi-dimensional effects in promotion of malignant cells. It also illuminates the relations of CD44 endorsed processes with other biomolecular events in cancer progression. In an end, the review focuses comprehensively at ongoing researches to exploit the CD44 over-expression as a probable target in treatment, management, and diagnosis of malignancy.
authors: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors: Lalit Mohan
authors: LM
authors: Negi
authors: Sushama
authors: S
authors: Talegaonkar
authors: Manu
authors: M
authors: Jaggi
authors: Farhan J
authors: FJ
authors: Ahmad
authors: Zeenat
authors: Z
authors: Iqbal
authors: Roop K
authors: RK
authors: Khar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D018450:Disease Progression; D004337:Drug Carriers / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D018432:Drug Resistance, Multiple / Q000502:physiology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D018960:Hyaluronan Receptors / Q000008:administration & dosage / Q000502:physiology*; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000502:physiology; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use; D008954:Models, Biological; D058726:Nanoconjugates / Q000008:administration & dosage; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D020033:Protein Isoforms / Q000008:administration & dosage / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; C497483:CD44 protein, human; D004337:Drug Carriers; D018960:Hyaluronan Receptors; D058726:Nanoconjugates; D020033:Protein Isoforms; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase