title: T1R3: a human calcium taste receptor.
abstract: Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3.
authors: Monell Chemical Senses Center, Philadelphia, PA 19104, USA. tordoff@monell.org
authors: Michael G
authors: MG
authors: Tordoff
authors: Laura K
authors: LK
authors: Alarcón
authors: Sitaram
authors: S
authors: Valmeki
authors: Peihua
authors: P
authors: Jiang
mesh_terms: D001555:Benzene Derivatives / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002122:Calcium Chloride / Q000494:pharmacology; D017610:Calcium Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression; D057809:HEK293 Cells; D006801:Humans; D007773:Lactates / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D013649:Taste / Q000502:physiology*; D055697:Taste Perception / Q000187:drug effects / Q000235:genetics*
chemical_list: D001555:Benzene Derivatives; D017610:Calcium Compounds; D007773:Lactates; D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1; C110051:calcium lactate; D002122:Calcium Chloride; D002118:Calcium; C495512:lactisole