title: Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation.
abstract: Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 ± 0.4 μM), while both are less toxic in the dark.
authors: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
authors: Samya
authors: S
authors: Banerjee
authors: Puja
authors: P
authors: Prasad
authors: Akhtar
authors: A
authors: Hussain
authors: Imran
authors: I
authors: Khan
authors: Paturu
authors: P
authors: Kondaiah
authors: Akhil R
authors: AR
authors: Chakravarty
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003474:Curcumin / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008027:Light; D018613:Microscopy, Confocal; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013057:Spectrum Analysis; D014638:Vanadates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D017319:Photosensitizing Agents; C075743:oxovanadium IV; D014638:Vanadates; D003474:Curcumin