title: High throughput synthesis of extended pyrazolo[3,4-d]dihydropyrimidines.
abstract: Thirteen 5-hetarylaminopyrazoles were synthesized in 62-93% yield through the arylation of 1-isopropyl- and 1-phenyl-5-aminopyrazoles with electrophilic hetarylhalides under optimized conditions. Condensation of 5-hetarylaminopyrazoles with carbonyl compounds facilitated by AcOH or Me(3)SiCl furnished 23 pyrazolo[3,4-d]dihydropyrimidines in 69-86% yield. The target compounds were isolated through simple crystallization. The scope and limitation of the method are discussed.
authors: The Institute of High Technologies, Kyiv National Taras Shevchenko University, Ukraine. s.v.ryabukhin@gmail.com
authors: Sergey V
authors: SV
authors: Ryabukhin
authors: Dmitry S
authors: DS
authors: Granat
authors: Andrey S
authors: AS
authors: Plaskon
authors: Alexander N
authors: AN
authors: Shivanyuk
authors: Andrey A
authors: AA
authors: Tolmachev
authors: Yulian M
authors: YM
authors: Volovenko
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines