title: Characterization of a tamoxifen-tethered single-walled carbon nanotube conjugate by using NMR spectroscopy.
abstract: We report the synthesis and characterization of a tamoxifen-tethered single-walled carbon nanotube (SWCNT) conjugate, in which tamoxifen is covalently attached to the single-walled carbon nanotube via oxidation and esterification reactions for the first time. The functionalized SWCNT derivative was characterized by using spectroscopic techniques: IR, UV-vis, Raman, and (1)H NMR Spectroscopy. The attachment of the drug tamoxifen to SWCNTs is analogous to the gold conjugate, which provided an endocrine treatment for breast cancer.
authors: Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA. djnelson@ou.edu
authors: Donna J
authors: DJ
authors: Nelson
authors: Shagufta
authors: Ravi
authors: R
authors: Kumar
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D006046:Gold; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013629:Tamoxifen / Q000737:chemistry*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D013629:Tamoxifen; D006046:Gold