title: Metronidazole esters: a new class of antiglycation agents.
abstract: A series of metronidazole ester derivatives 1-34 has been synthesized with the aim of developing new leads with antiglycation activity. The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28, 16, and 3 have IC(50) values 218.97 ± 2.5, 245.3 ± 5.1, and 278.6 ± 0.8 µM, respectively, comparable to the standard agent, rutin (IC(50) = 294.5 ± 1.50 µM). The study identifies a new class of potent antiglycation agents. A structure-activity relationship has also been evaluated. All the compounds were characterized by using spectroscopic techniques, including (1)H NMR, IR, and EI-MS.
authors: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
authors: Aurang
authors: A
authors: Zeb
authors: Imran
authors: I
authors: Malik
authors: Saima
authors: S
authors: Rasheed
authors: Muhammad Iqbal
authors: MI
authors: Choudhary
authors: Fatima Z
authors: FZ
authors: Basha
mesh_terms: D000818:Animals; D002417:Cattle; D004952:Esters; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D012431:Rutin / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012996:Solutions; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D004952:Esters; D017127:Glycation End Products, Advanced; D012996:Solutions; D008795:Metronidazole; D012710:Serum Albumin, Bovine; D012431:Rutin