title: [The new paradigm of neonatal hemochromatosis: fetal alloimmune hepatitis].
abstract: The classical model of neonatal hemochromatosis was based on the analogy with hereditary hemochromatosis. Medical treatment consisted on the antioxidant-chelator cocktail. The new hypothesis of an alloimmune origin of the process by which the pregnant woman mounts an IgG-based destructive response against fetal hepatocytes offers a pathogenic explanation, allowing treatment to be focused on the immunological aspects, with excellent results, and opens the possibility of preventive treatment in future pregnancies. This new paradigm produces a deep impact in diagnosis, prognosis and treatment of the disease, that should be called "fetal alloimmune hepatitis".
authors: Unidad de Hígado y Trasplante Hepático, Sanatorio de Niños, Rosario, Argentina. alejandro.costaguta@gmail.com
authors: Alejandro
authors: A
authors: Costaguta
authors: Fernando
authors: F
authors: Alvarez
mesh_terms: D005315:Fetal Diseases / Q000276:immunology; D006432:Hemochromatosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn