title: [Potential of impression cytology in diagnosis and evaluation of efficacy of pharmacological correction of dry eye syndrome associated with contact lens wearing].
abstract: Potential of impression cytology in diagnosis and evaluation of efficacy of pharmacological correction of dry eye syndrome (DES) associated with contact lens wearing was studied. When wearing contact lenses for a long time DES with tear film instability and reduction of tear production occurs in more than 50% patients. Morphological changes of epithelium of tarsal and bulbar conjunctiva manifest consequently. Impression cytology reveals structural damage of epithelium with keratinization signs and decrease of goblet cells density down to total absence. After tear substitution therapy tear break-up time increased by 65,3% and total tear production by 11,4%. In control impression cytology of tarsal and bulbar conjunctiva during tear substitution therapy the following changes were revealed: recovery of goblet cells density and differentiation, recovery of epithelial structure and reduction of epithelium keratinization.
authors: G B
authors: GB
authors: Egorova
authors: A A
authors: AA
authors: Fedorova
authors: T S
authors: TS
authors: Mitichkina
mesh_terms: D000328:Adult; D003228:Conjunctiva / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D003261:Contact Lenses / Q000009:adverse effects*; D003581:Cytodiagnosis / Q000379:methods*; D015352:Dry Eye Syndromes / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D019573:Epithelium, Corneal / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000503:physiopathology; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D013666:Tears / Q000378:metabolism; D016896:Treatment Outcome; D055675:Viscosupplements / Q000627:therapeutic use
chemical_list: D009883:Ophthalmic Solutions; D055675:Viscosupplements; D006820:Hyaluronic Acid