title: Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.
abstract: Mitotic arrest deficiency 2 (MAD2) is a key component of the mitotic spindle checkpoint pathway. A compromised mitotic spindle checkpoint results in an abnormal number of chromosomes. This is referred to as chromosomal instability, and has been reported in most types of human cancer. The aim of this study was to examine the expression of MAD2 in mucinous ovarian tumors exhibiting varying degrees of malignancy. We reviewed 128 cases of mucinous ovarian tumors initially treated at Osaka City University Medical School Hospital, Japan. Tumor samples were obtained following surgery. The cases were divided into three groups: benign (group B; n=30), borderline malignant (group BM; n=55) and malignant (group M; n=43). MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method. Results showed MAD2 expression to be significantly greater in group M compared to groups B and BM (P<0.05). In addition, there was a moderate correlation between MAD2 expression and the degree of malignancy (r=0.51, P<0.05). However, when the samples in group M were classified according to a low or high expression of MAD2, no difference was observed in terms of overall survival. These findings suggest that the overexpression of MAD2 may be correlated to carcinogenesis in mucinous ovarian tumors.
authors: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
authors: Yusuke
authors: Y
authors: Nakano
authors: Toshiyuki
authors: T
authors: Sumi
authors: Masanari
authors: M
authors: Morishita
authors: Takeshi
authors: T
authors: Fukuda
authors: Hiroyuki
authors: H
authors: Nobeyama
authors: Hiroyuki
authors: H
authors: Yoshida
authors: Yoshinari
authors: Y
authors: Matsumoto
authors: Tomoyo
authors: T
authors: Yasui
authors: Osamu
authors: O
authors: Ishiko