title: TAR DNA binding protein-43 and fused in sarcoma/translocated in liposarcoma protein in two neurodegenerative diseases.
abstract: TAR DNA binding protein-43(TDP-43) and fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) have been found to be associated with two neurodegenerative diseases - amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TDP-43 and FUS/TLS lead to abnormal protein expressions, which result in altered RNA processing. The pathological changes of TDP-43 and FUS/TLS-associated ALS and FTD are similar. Although the interactions between ALS and FTD remain unknown, it is speculated that TDP-43 and FUS/TLS-associated neurodegenerative diseases may share similar pathogenesis.
authors: Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Xin-ning
authors: XN
authors: Wang
authors: Li-ying
authors: LY
authors: Cui
mesh_terms: D000690:Amyotrophic Lateral Sclerosis; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D057180:Frontotemporal Dementia; D006801:Humans; D009154:Mutation; D012323:RNA Processing, Post-Transcriptional; D034702:RNA-Binding Protein FUS / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D034702:RNA-Binding Protein FUS