title: Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype.
abstract: BACKGROUND
  The sticky platelet syndrome (SPS) seems to be a common cause of thrombosis, although no molecular substrate to explain platelet hyperaggregability has been found.
  
  
  OBJECTIVE
  To analyze an association between the SPS phenotype and the platelet glycoprotein (GP) IIIa PL(A1/A2) (human platelet antigen [HPA]-1a/b) gene polymorphism.
  
  
  METHODS
  Along an 18-month period, Mexican mestizo thrombophilic patients were prospectively accrued. The SPS phenotype was assessed by aggregometry, whereas a tetra-primer amplification refractory mutation system (ARMS) polymerase chain reaction analysis was used to detect the PLA1 and PLA2 alleles.
  
  
  RESULTS
  A total of 95 individuals with SPS and 127 healthy donors were studied; in 11 of the donors and 16 of the patients with SPS the A2 allele of the GP IIb/IIIA was found, yielding a weak and nonsignificant association (odds ratio 2.14, 95% CI 0.94-4.85).
  
  
  CONCLUSIONS
  In Mexican mestizo patients, the platelet GP IIIa PL(A1/A2) gene polymorphism does not lead to the SPS phenotype.
authors: 1Centro de Hematología y Medicina Interna de Puebla, Mexico.
authors: Guillermo J
authors: GJ
authors: Ruiz-Argüelles
authors: Javier
authors: J
authors: Garcés-Eisele
authors: Cecilia
authors: C
authors: Camacho-Alarcón
authors: Virginia
authors: V
authors: Reyes-Nuñez
authors: Benjamín
authors: B
authors: Moncada-González
authors: Patricia
authors: P
authors: Valdés-Tapia
authors: Nancy
authors: N
authors: León-Montes
authors: Guillermo J
authors: GJ
authors: Ruiz-Delgado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001791:Blood Platelet Disorders / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010641:Phenotype; D010974:Platelet Aggregation / Q000235:genetics*; D011110:Polymorphism, Genetic; D013577:Syndrome; D019851:Thrombophilia / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D055815:Young Adult
chemical_list: D039661:Integrin beta3