title: H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine.
abstract: Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus. Recent work has shown that the maternal genome is protected from this remodeling step by an interaction between a modified histone, H3K9me2, and the oocyte-derived factor, PGC7, to prevent oxidation of the maternal DNA by the Tet3 5-methylcytosine oxidase.
authors: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA. pszabo@coh.org
authors: Piroska E
authors: PE
authors: Szabó
authors: Gerd P
authors: GP
authors: Pfeifer
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D049308:Dioxygenases / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D057890:Epigenomics / Q000379:methods; D016678:Genome / Q000235:genetics; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D008322:Mammals / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D010084:Oxidation-Reduction; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015053:Zygote / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; D012097:Repressor Proteins; D044503:5-Methylcytosine; D004247:DNA; D049308:Dioxygenases