title: Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects.
abstract: OBJECTIVE
  Serum uric acid (SUA) is a cardiovascular risk marker associated with inflammation. The serum amyloid A protein (SAA) is an inflammatory factor and is associated with cardiovascular disease (CVD). However, the relationship between genetic polymorphisms of SAA and SUA levels has not been studied. The objective of this study was to investigate the association between SUA levels and SAA genetic polymorphisms.
  
  
  METHODS
  All participants were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. The single nucleotide polymorphism (SNP) rs12218 of the SAA1 gene was genotyped by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The association of SUA levels with genotypes was assessed by using the general liner mode.
  
  
  RESULTS
  The SNP rs12218 was associated with SUA levels by analyses of a dominate model (P = 0.002) and additive model (P = 0.005), and the difference remained significant after adjustment of sex, age, obesity, ethnicity, HDL-C, alcohol intake, smoking, and creatinine (P = 0.006 and P = 0.023, respectively). The TT genotype was associated with an increased SUA concentration of 39.34 mmol/L (95% confidence interval [CI], 3.61-75.06, P = 0.031) compared with the CC genotype, and the TT genotype was associated with an increased SUA concentration of 2.48 mmol/L (95% CI, 6.86-38.10; P = 0.005) compared with the CT genotype.
  
  
  CONCLUSIONS
  The rs12218 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia.
authors: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
authors: Xiang
authors: X
authors: Xie
authors: Yi-Tong
authors: YT
authors: Ma
authors: Yi-Ning
authors: YN
authors: Yang
authors: Xiao-Mei
authors: XM
authors: Li
authors: Zhen-Yan
authors: ZY
authors: Fu
authors: Ying-Ying
authors: YY
authors: Zheng
authors: Xiang
authors: X
authors: Ma
authors: Bang-Dang
authors: BD
authors: Chen
authors: Fen
authors: F
authors: Liu
authors: Ying
authors: Y
authors: Huang
authors: Zi-Xiang
authors: ZX
authors: Yu
authors: You
authors: Y
authors: Chen
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D015986:Confounding Factors, Epidemiologic; D003710:Demography; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014527:Uric Acid / Q000097:blood*
chemical_list: C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein; D014527:Uric Acid