title: Pretreatment plasma levels and diagnostic utility of hematopoietic cytokines in cervical cancer or cervical intraepithelial neoplasia patients.
abstract: In this study, we compared plasma levels and the diagnostic utility of hematopoietic growth factors (HGFs) with SCC-Ag in cervical cancer patients in relation to control groups and cervical intraepithelial neoplasia (CIN) patients and healthy subjects. Pretreatment plasma levels of HGFs (SCF, GM-CSF, G-CSF and M-CSF) were determined by the use of immunoenzyme assay (ELISA), and SCC-Ag by chemiluminescent microparticle immunoassay (CMIA). Significantly different concentrations of GM-CSF, G-CSF and M-CSF were observed in the group of patients with cervical cancer and CIN compared to the healthy controls. Significant differences in plasma levels of GM-CSF and M-CSF between cervical cancer and benign lesions patients were also found. The HGFs and SCC-Ag diagnostic specificities received high values. The diagnostic sensitivity and the predictive value of a positive and negative test result were higher for M-CSF than for antigen SCC in the cancer group. The M-CSF area under the ROC curve (AUC) was the largest from hematopoietic cytokines and SCC-Ag. These results suggest the potential utility of M-CSF as a good candidate for a marker of cervical cancer as well as benign lesions of this organ (CIN).
authors: Department of Biochemical Diagnostics, Medical University of Białystok, Poland.
authors: Sławomir
authors: S
authors: Ławicki
authors: Grażyna E
authors: GE
authors: Będkowska
authors: Ewa
authors: E
authors: Gacuta-Szumarska
authors: Paweł
authors: P
authors: Knapp
authors: Maciej
authors: M
authors: Szmitkowski
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D008875:Middle Aged; D012372:ROC Curve; D015843:Serpins / Q000097:blood; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D016207:Cytokines; D015843:Serpins; C051072:squamous cell carcinoma-related antigen