title: Acute febrile respiratory reaction after praziquantel treatment during asymptomatic late form of acute schistosomiasis.
abstract: Paradoxical reactions (Jarish Herxheimer-like reactions) have been described in patients treated with praziquantel (PZQ) during acute schistosomiasis (infected≤ 3 mo), while PZQ treatment of chronic schistosomiasis is generally considered to be safe. We report an acute febrile reaction with respiratory decompensation following PZQ treatment in a 17-year-old male patient who had no potential (re)exposure to infection for at least 5 months and was therefore considered to have reached the chronic stage of disease. We speculate that the clinical manifestations in our patient constitute a very late paradoxical reaction in an unusually long acute phase of infection.
authors: Swiss Tropical and Public Health Institute, Medical and Diagnostic Services, Socinstrasse 57, Basel, Switzerland. andreas.neumayr@unibas.ch
authors: Andreas L C
authors: AL
authors: Neumayr
authors: Beatrice
authors: B
authors: Tschirky
authors: Ashley
authors: A
authors: Warren
authors: Christoph F R
authors: CF
authors: Hatz
authors: Johannes A
authors: JA
authors: Blum
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D003371:Cough / Q000139:chemically induced; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000139:chemically induced*; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000009:adverse effects* / Q000627:therapeutic use; D012552:Schistosomiasis / Q000188:drug therapy*; D012556:Schistosomicides / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012556:Schistosomicides; D011223:Praziquantel