title: MicroRNAs in esophageal cancer (review).
abstract: Esophageal cancer (EC) is one of the most common malignant tumors worldwide.             EC is usually diagnosed at a locally advanced stage or at a stage with involvement             of lymph nodes. Despite aggressive treatment, the overall five-year survival rate             remains poor. microRNAs (miRNAs) are small, non-coding endogenous RNAs that negatively             regulate gene expression at the post-transcriptional and/or translational level.             Accumulating evidence suggests that the deregulation of miRNAs not only results             in cancer progression, but also directly promotes tumor initiation. Previous studies             found that miRNAs are frequently deregulated in EC, indicating that miRNAs are             important in tumorigenesis. In this review, we summarize therecently recognized             miRNA expression and its impact on the biology of EC and the potential applications             for EC.
authors: Department of Cardiothoracic Surgery, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
authors: Bin
authors: B
authors: He
authors: Bangliang
authors: B
authors: Yin
authors: Baoxiang
authors: B
authors: Wang
authors: Zhenkun
authors: Z
authors: Xia
authors: Chen
authors: C
authors: Chen
authors: Jingqun
authors: J
authors: Tang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs