title: Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist.
abstract: OBJECTIVE
  Idiopathic central precocious puberty and its postponement with a (gonadotropin-releasing hormone) GnRH agonist are complex conditions, the final effects of which on bone mass are difficult to define. We evaluated bone mass, body composition, and bone remodeling in two groups of girls with idiopathic central precocious puberty, namely one group that was assessed at diagnosis and a second group that was assessed three years after GnRH agonist treatment.
  
  
  METHODS
  The precocious puberty diagnosis and precocious puberty treatment groups consisted of 12 girls matched for age and weight to corresponding control groups of 12 (CD) and 14 (CT) girls, respectively. Bone mineral density and body composition were assessed by dual X-ray absorptiometry. Lumbar spine bone mineral density was estimated after correction for bone age and the mathematical calculation of volumetric bone mineral density. CONEP: CAAE-0311.0.004.000-06.
  
  
  RESULTS
  Lumbar spine bone mineral density was slightly increased in individuals diagnosed with precocious puberty compared with controls; however, after correction for bone age, this tendency disappeared (CD = -0.74 + 0.9 vs. precocious puberty diagnosis = -1.73 + 1.2). The bone mineral density values of girls in the precocious puberty treatment group did not differ from those observed in the CT group.
  
  
  CONCLUSIONS
  There is an increase in bone mineral density in girls diagnosed with idiopathic central precocious puberty. Our data indicate that the increase in bone mineral density in girls with idiopathic central precocious puberty is insufficient to compensate for the marked advancement in bone age observed at diagnosis. GnRH agonist treatment seems to have no detrimental effect on bone mineral density.
authors: Department of Internal Medicine, School of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
authors: Sandra B
authors: SB
authors: Alessandri
authors: Francisco de A
authors: Fde A
authors: Pereira
authors: Rosângela A
authors: RA
authors: Villela
authors: Sonir R R
authors: SR
authors: Antonini
authors: Paula C L
authors: PC
authors: Elias
authors: Carlos E
authors: CE
authors: Martinelli
authors: Margaret de
authors: Md
authors: Castro
authors: Ayrton C
authors: AC
authors: Moreira
authors: Francisco J A de
authors: FJ
authors: Paula
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000367:Age Factors; D001823:Body Composition / Q000187:drug effects / Q000502:physiology*; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000473:pathology*; D012016:Reference Values; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007987:Gonadotropin-Releasing Hormone