title: Can delivery dialysis dose affect survival of acute kidney injury patients?
abstract: Intensity of dialysis dose in acute kidney injury (AKI) might benefit critically ill patients. The aim of this study was to evaluate the effect of intermittent hemodialysis (IHD) dose on mortality in patients with AKI.
  
  
  METHODS
  Prospective observational study was performed on AKI patients treated with IHD. The delivered dialysis dose per session was calculated based on single-pool Kt/V urea. Patients were allocated in two groups according to the weekly delivered median Kt/V: higher intensity dialysis dose (HID: Kt/V higher than median) and lower intensity dialysis dose (LID: Kt/V lower than median). Thereafter, AKI patients were divided according to the presence or absence of sepsis and urine output. Clinical and lab characteristics and survival of AKI patients were compared.
  
  
  RESULTS
  A total of 121 AKI patients were evaluated. Forty-two patients did not present with sepsis and 45 did not present with oliguria. Mortality rate after 30 days was lower in the HID group without sepsis (14.3% × 47.6%; p = 0.045) and without oliguria (31.8% × 69.5%; p = 0.025). Survival curves also showed that the HID group had higher survival rate when compared with the LID group in non-septic and non-oliguric patients (p = 0.007 and p = 0.003, respectively).
  
  
  CONCLUSIONS
  Higher dialysis doses can be associated with better survival of less seriously ill AKI patients.
authors: Department of Internal Medicine, Botucatu School of Medicine, UNESP, Botucatu, São Paulo, Brazil. abrao_ju@yahoo.com.br
authors: Juliana Maria Gera
authors: JM
authors: Abrão
authors: Daniela
authors: D
authors: Ponce
authors: Germana Alves
authors: GA
authors: de Brito
authors: André Luís
authors: AL
authors: Balbi
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality* / Q000628:therapy; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000628:therapy; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D018805:Sepsis / Q000453:epidemiology / Q000401:mortality*; D015996:Survival Rate