title: Lowered serum amyloid-β1-42 autoantibodies in individuals with lifetime depression.
abstract: Reduced levels of naturally occurring autoantibodies against amyloid-β (Aβ) have been described in Alzheimer's disease (AD). Lifetime depression doubles the risk of AD, thus these autoantibodies may also be reduced in this group. We measured serum IgG autoantibody titers against Aβ1-42, S100b and α-synuclein in 214 individuals with depression and 419 controls. Titers against Aβ1-42 were lower in individuals with lifetime depression (5544.6 ± 389.3) compared to controls (7208.7 ± 482.4; p = 0.048). Titers against S100b and α-synuclein were comparable between the cohorts. These data suggest an AD-like impairment of the humoral immune response in a relevant proportion of individuals with depression.
authors: Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tübingen, Tübingen, Germany. walter.maetzler@uni-tuebingen.de
authors: Walter
authors: W
authors: Maetzler
authors: Markus
authors: M
authors: Langkamp
authors: Stefanie
authors: S
authors: Lerche
authors: Jana
authors: J
authors: Godau
authors: Kathrin
authors: K
authors: Brockmann
authors: Alexandra
authors: A
authors: Gaenslen
authors: Heiko
authors: H
authors: Huber
authors: Isabel
authors: I
authors: Wurster
authors: Raphael
authors: R
authors: Niebler
authors: Gerhard W
authors: GW
authors: Eschweiler
authors: Daniela
authors: D
authors: Berg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers; D015331:Cohort Studies; D003710:Demography; D003863:Depression / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000276:immunology / Q000378:metabolism; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000276:immunology*; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism; D051844:alpha-Synuclein / Q000097:blood
chemical_list: D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D015415:Biomarkers; D009414:Nerve Growth Factors; D010446:Peptide Fragments; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D051844:alpha-Synuclein; C075222:amyloid beta-protein (1-42)