title: Systemic-lupus-erythematosus-related acute pancreatitis: a cohort from South China.
abstract: Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for the mortality of patients with SLE-related AP in a cohort of South China.
  
  
  METHODS
  Inpatient medical records of SLE-related AP were retrospectively reviewed.
  
  
  RESULTS
  27 out of 4053 SLE patients were diagnosed as SLE-related AP, with an overall prevalence of 0.67%, annual incidence of 0.56‰ and mortality of 37.04%. SLE patients with AP presented with higher SLEDAI score (21.70 ± 10.32 versus 16.17 ± 7.51, P = 0.03), more organ systems involvement (5.70 ± 1.56 versus 3.96 ± 1.15, P = 0.001), and higher mortality (37.04% versus 0, P = 0.001), compared to patients without AP. Severe AP (SAP) patients had a significant higher mortality rate compared to mild AP (MAP) (75% versus 21.05%, P = 0.014). 16 SLE-related AP patients received intensive GC treatment, 75% of them exhibited favorable prognosis.
  
  
  CONCLUSIONS
  SLE-related AP is rare but concomitant with high mortality in South Chinese people, especially in those SAP patients. Activity of SLE, multiple-organ systems involvement may attribute to the severity and mortality of AP. Appropriate glucocorticosteroid (GC) treatment leads to better prognosis in majority of SLE patients with AP.
authors: Department of Rheumatology, The 1st Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
authors: Yanlong
authors: Y
authors: Yang
authors: Yujin
authors: Y
authors: Ye
authors: Liuqin
authors: L
authors: Liang
authors: Tianfu
authors: T
authors: Wu
authors: Zhongping
authors: Z
authors: Zhan
authors: Xiuyan
authors: X
authors: Yang
authors: Hanshi
authors: H
authors: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult