title: ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca.
abstract: The ZNF804A rs1344706 variant was the first risk factor to be identified through genome-wide association studies and follow-up studies with meta-analysis for schizophrenia as well as bipolar disorders; we investigated 231 schizophrenia and 222 controls to see whether this particular variant was associated with schizophrenia in a Romanian population from Cluj Napoca. Clearly, there was no association between the ZNF804A rs1344706 variant and schizophrenia. Our study provides evidence for those that found no association with schizophrenia. A surprising result of our study was that the T allele frequency is the highest, thus far among the ethnic groups studied. We used a PCR-RFLP method that had been recently developed in our laboratory to the genotype ZNF804A rs1344706 variant. In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693).
authors: Department of Psychiatry, University of Medicine and Pharmacy Iuliu Hatieganu Cluj, Cluj Napoca, Romania.
authors: Andreea
authors: A
authors: Zaharie
authors: Emel
authors: E
authors: Ergul
authors: Mavi Deniz
authors: MD
authors: Ozel
authors: Ioana Valentina
authors: IV
authors: Miclutia
authors: Mihaela Fadgyas
authors: MF
authors: Stanculete
authors: Ali
authors: A
authors: Sazci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012383:Romania; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human