title: Relationship between plasma leptin levels and clinical outcomes of pediatric traumatic brain injury.
abstract: High plasma leptin level has been associated with mortality after adult intracerebral hemorrhage. The present study was undertaken to investigate the plasma leptin concentrations in children with traumatic brain injury and to analyze the correlation of leptin with pediatric traumatic brain injury outcome. Plasma leptin concentration of eighty-nine healthy children and 142 children with acute severe traumatic brain injury was measured by enzyme-linked immunosorbent assay. Twenty-six patients (18.3%) died and 42 patients (29.6%) had an unfavorable outcome (Glasgow outcome scale score of 1-3) at 6 months after traumatic brain injury. Upon admission, plasma leptin level in patients was substantially higher than that in healthy controls. A forward stepwise logistic regression selected plasma leptin level as an independent predictor for 6-month mortality and unfavorable outcome of patients. A receiver operating characteristic curve analysis showed plasma leptin level better predicted 6-month mortality and unfavorable outcome. The prognostic value of leptin was similar to that of Glasgow Coma scale score for 6-month clinical outcomes. Thus, plasma leptin level represents a novel biomarker for predicting 6-month clinical outcome in children with traumatic brain injury.
authors: Department of Neurosurgery, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors: Chao
authors: C
authors: Lin
authors: Shou-Jiang
authors: SJ
authors: Huang
authors: Ning
authors: N
authors: Wang
authors: Zhi-Peng
authors: ZP
authors: Shen
mesh_terms: D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood / Q000401:mortality / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D011379:Prognosis
chemical_list: D015415:Biomarkers; D020738:Leptin