title: A brief history of anti-VEGF for the treatment of ocular angiogenesis.
abstract: In 1994, The American Journal of Pathology published a key article reporting that hypoxic retina produces vascular endothelial growth factor (VEGF), suggesting a role for VEGF in ocular neovascularization. Subsequent developments in anti-VEGF treatment for neovascular eye disease have improved visual outcomes and changed the standard of care in retinal medicine and ophthalmology.
authors: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors: Leo A
authors: LA
authors: Kim
authors: Patricia A
authors: PA
authors: D'Amore
mesh_terms: D020533:Angiogenesis Inhibitors / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D005123:Eye / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A