title: Endoscopic imaging of Cerenkov luminescence.
abstract: We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 µCi of radioactivity emitted from (18)F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with (18)F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.
authors: Sri-Rajasekhar
authors: SR
authors: Kothapalli
authors: Hongguang
authors: H
authors: Liu
authors: Joseph C
authors: JC
authors: Liao
authors: Zhen
authors: Z
authors: Cheng
authors: Sanjiv Sam
authors: SS
authors: Gambhir