title: Influence of an acetate- and a lactate-based balanced infusion solution on acid base physiology and hemodynamics: an observational pilot study.
abstract: BACKGROUND
  The current pilot study compares the impact of an intravenous infusion of Ringer's lactate to an acetate-based solution with regard to acid-base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects have been reported when using acetate buffered solutions in hemodialysis, hemodynamics were also evaluated.
  
  
  METHODS
  Twenty-four women who had undergone abdominal gynecologic surgery and who had received either Ringer's lactate (Strong Ion Difference 28 mmol/L; n = 12) or an acetate-based solution (Strong Ion Difference 36.8 mmol/L; n = 12) according to an established clinical protocol and its precursor were included in the investigation. After induction of general anesthesia, a set of acid-base variables, hemodynamic values and serum electrolytes was measured three times during the next 120 minutes.
  
  
  RESULTS
  Patients received a mean dose of 4,054 ± 450 ml of either one or the other of the solutions. In terms of mean arterial blood pressure and norepinephrine requirements there were no differences to observe between the study groups. pH and serum HCO3- concentration decreased slightly but significantly only with Ringer's lactate. In addition, the acetate-based solution kept the plasma effective strong ion difference more stable than Ringer's lactate.
  
  
  CONCLUSIONS
  Both of the solutions provided hemodynamic stability. Concerning consistency of acid base parameters none of the solutions seemed to be inferior, either. Whether the slight advantages observed for the acetate-buffered solution in terms of stability of pH and plasma HCO3- are clinically relevant, needs to be investigated in a larger randomized controlled trial.
authors: Clinic of Anesthesiology, Ludwig-Maximilians University, City of Munich, Germany. Klaus.Hofmann-Kiefer@med.uni-muenchen.de
authors: Klaus F
authors: KF
authors: Hofmann-Kiefer
authors: Daniel
authors: D
authors: Chappell
authors: Tobias
authors: T
authors: Kammerer
authors: Matthias
authors: M
authors: Jacob
authors: Michaela
authors: M
authors: Paptistella
authors: Peter
authors: P
authors: Conzen
authors: Markus
authors: M
authors: Rehm
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology*; D000328:Adult; D000368:Aged; D062186:Arterial Pressure; D001639:Bicarbonates / Q000097:blood; D002021:Buffers; D004562:Electrocardiography; D004573:Electrolytes / Q000097:blood; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007260:Infusion Pumps; D007262:Infusions, Intravenous / Q000379:methods*; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage; D010865:Pilot Projects; D000077325:Ringer's Lactate; D055815:Young Adult
chemical_list: D000085:Acetates; D001639:Bicarbonates; D002021:Buffers; D004573:Electrolytes; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D009638:Norepinephrine