title: [Inhibitory effect of bioginseng on radiation-induced carcinogenesis in rats].
abstract: Influence of bioginseng (biotechnological pharmaceutical drug from ginseng radix culture) on radiation-induced carcinogenesis has been studied. LIO female rats were divided into 3 groups. Rats of the first group (n=25) were used as intact control and weren't exposed to any influence. Rats of the second (n=50) and third (n=50) groups were exposed to single total body gamma-irradiation at a dose of 4 Gy. Animals of the 2nd group weren't exposed to any influence after irradiation, while animals of the 3rd group were given bioginseng with tap water (20 ml/l) until the end of study (438 days). In the control group 22,7% of animals developed tumors. In the 2nd group (irradiated control) 70% of animals were bearing multiple tumors one third of which were malignant. Mammary gland tumors were most frequent. Compared to the 2nd group the 3rd group receiving irradiation and bioginseng demonstrated the decrease in tumor incidence by 24.5% and 2,4 rate of decrease in tumors number. For the malign tumors was observed the decrease by 26.8% and 2,9 times, accordingly. For the mammary tumors the decrease was by 23.0% and 2,0 times, for mammary adenocarcinomas by 23.4% and 3,5 times, accordingly. The incidence and number of endocrine and reproductive organs tumors was 20,9% and 5,6 times, accordingly. Therefore, bioginseng effectively inhibits carcinogenesis induced by ionizing radiation in female rats.
authors: V G
authors: VG
authors: Bespalov
authors: V A
authors: VA
authors: Aleksandrov
authors: A L
authors: AL
authors: Semenov
authors: E G
authors: EG
authors: Kovan'ko
authors: S D
authors: SD
authors: Ivanov
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001709:Biotechnology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000517:prevention & control*; D005894:Panax; D028321:Plant Preparations / Q000494:pharmacology*; D051381:Rats; D016019:Survival Analysis; D014916:Whole-Body Irradiation
chemical_list: D016588:Anticarcinogenic Agents; D028321:Plant Preparations