title: Temperature control at DBS electrodes using a heat sink: experimentally validated FEM model of DBS lead architecture.
abstract: There is a growing interest in the use of deep brain stimulation (DBS) for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. The extent of temperature increases around DBS electrodes during normal operation (joule heating and increased metabolic activity) or coupling with an external source (e.g. magnetic resonance imaging) remains poorly understood and methods to mitigate temperature increases are being actively investigated. We developed a heat transfer finite element method (FEM) simulation of DBS incorporating the realistic architecture of Medtronic 3389 leads. The temperature changes were analyzed considering different electrode configurations, stimulation protocols and tissue properties. The heat-transfer model results were then validated using micro-thermocouple measurements during DBS lead stimulation in a saline bath. FEM results indicate that lead design (materials and geometry) may have a central role in controlling temperature rise by conducting heat. We show how modifying lead design can effectively control temperature increases. The robustness of this heat-sink approach over complimentary heat-mitigation technologies follows from several features: (1) it is insensitive to the mechanisms of heating (e.g. nature of magnetic coupling); (2) it does not interfere with device efficacy; and (3) can be practically implemented in a broad range of implanted devices without modifying the normal device operations or the implant procedure.
authors: Department of Biomedical Engineering, The City College of New York of The City University of New York, NY, USA.
authors: Maged M
authors: MM
authors: Elwassif
authors: Abhishek
authors: A
authors: Datta
authors: Asif
authors: A
authors: Rahman
authors: Marom
authors: M
authors: Bikson
mesh_terms: D001921:Brain / Q000502:physiology; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004567:Electrodes, Implanted; D006358:Hot Temperature; D006801:Humans; D008959:Models, Neurological; D013814:Thermal Conductivity