title: Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C-O reduction approach.
abstract: Unsaturated cyclic ethers can be mildly and selectively reduced with catalytic amounts of B(C(6)F(5))(3) in the presence of an alkylsilane. The allylic position is preferentially reduced with minimal or no scrambling of olefin geometry. For electronically equivalent substrates, steric factors guide the reducing agent to the least substituted site.
authors: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY, USA.
authors: Daniel J
authors: DJ
authors: Mack
authors: Boying
authors: B
authors: Guo
authors: Jon T
authors: JT
authors: Njardarson