title: Marked elevation of interferon-γ in acute focal bacterial nephritis.
abstract: Acute focal bacterial nephritis (AFBN) is a localized, interstitial bacterial infection of the renal parenchyma. In this study, we measured the serum levels of several cytokines in patients with AFBN. A total of 11 children were enrolled in the study and classified into two groups of patients: an AFBN group and a control group. There was no significant difference in the serum levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, granulocyte-colony stimulating factor, or tumor necrosis factor-α among the patients in the two groups. However, the serum levels of interferon-γ among the patients in the AFBN group were significantly higher than those among the patients in the control group. The current results suggest that the bacterial kidney infection in the AFBN group is localized and that interferon-γ may be produced locally in response to the infection.
authors: Yasuyo
authors: Y
authors: Kashiwagi
authors: Hisashi
authors: H
authors: Kawashima
authors: Shonosuke
authors: S
authors: Nara
authors: Masanobu
authors: M
authors: Ushio
authors: Shigeo
authors: S
authors: Nishimata
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D013293:Enterococcus faecalis / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008297:Male; D009393:Nephritis / Q000097:blood* / Q000382:microbiology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor