title: Differential expression of PDZ domain-containing proteins in human diseases - challenging topics and novel issues.
abstract: The general features of the PDZ domain structure and functions have been extensively studied during the last decade. PDZ domains are generally present in proteins that are involved in multiple interactions to assemble functional protein complexes that control key cellular processes. One of the best characterized functions of PDZ domain-containing proteins is control of epithelial cell polarity and cell-cell contacts. In the present review, we summarize the current knowledge on regulation of expression of certain PDZ polarity proteins localized at the intercellular junctions. In addition, we provide a critical overview of recent findings regarding the role of these proteins during development of human diseases. Complete understanding of these issues is valuable for the design of novel therapeutic intervention for common pathologies, such as cancer.
authors: Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario (IBR)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rosario, Argentina.
authors: Florencia
authors: F
authors: Facciuto
authors: Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario (IBR)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rosario, Argentina.
authors: Ana L
authors: AL
authors: Cavatorta
authors: Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario (IBR)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rosario, Argentina.
authors: Marina Bugnon
authors: MB
authors: Valdano
authors: Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario (IBR)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rosario, Argentina.
authors: Federico
authors: F
authors: Marziali
authors: Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario (IBR)-Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Rosario, Argentina.
authors: Daniela
authors: D
authors: Gardiol
mesh_terms: D004194:Disease / Q000209:etiology*; D005786:Gene Expression Regulation; D006801:Humans; D054731:PDZ Domains / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins