title: Regulated proteolysis as a force to control the cell cycle.
abstract: In this issue of Structure, Rood and colleagues report that substrate architecture is a key factor in promoting the complete and processive degradation of the Caulobacter cell cycle regulator PdeA by the protease ClpXP. This investigation highlights the important role that the adaptor protein CpdR serves in regulating presentation of PdeA to ClpXP.
authors: Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. cambergj@mail.nih.gov
authors: Jodi L
authors: JL
authors: Camberg
authors: Sue
authors: S
authors: Wickner