title: A pathogenetic link between non-alcoholic fatty liver disease and celiac disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) has recently been recognized as the leading cause of the abnormalities in the liver function tests in the Western countries. Celiac disease (CD) is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. CD has been reported in 4-13 % of the cases with steatohepatitis, although the pathogenesis of the liver steatosis in CD patients is unclear. Based on the literature data, it can be concluded that the inclusion of serological markers of CD should be a part of the general workup in the patients with steatosis when other causes of the liver disease are excluded and in the patients with NAFLD when metabolic risk factors are not evident.
authors: Department of Health Sciences, University "Magna Græcia", Viale Europa, 88100, Catanzaro, Italy. l.abenavoli@unicz.it
authors: Ludovico
authors: L
authors: Abenavoli
authors: Natasa
authors: N
authors: Milic
authors: Antonino
authors: A
authors: De Lorenzo
authors: Francesco
authors: F
authors: Luzza
mesh_terms: D002446:Celiac Disease / Q000178:diet therapy / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D055050:Diet, Gluten-Free / Q000009:adverse effects; D005234:Fatty Liver / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D006090:Gram-Negative Bacteria / Q000254:growth & development / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008070:Lipopolysaccharides / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D065626:Non-alcoholic Fatty Liver Disease; D010539:Permeability
chemical_list: D008070:Lipopolysaccharides