title: Electrospun nanofibrous 3D scaffold for bone tissue engineering.
abstract: Tissue engineering aims at developing functional substitutes for damaged tissues by mimicking natural tissues. In particular, tissue engineering for bone regeneration enables healing of some bone diseases. Thus, several methods have been developed in order to produce implantable biomaterial structures that imitate the constitution of bone. Electrospinning is one of these methods. This technique produces nonwoven scaffolds made of nanofibers which size and organization match those of the extracellular matrix. Until now, seldom electrospun scaffolds were produced with thickness exceeding one millimeter. This article introduces a new kind of electrospun membrane called 3D scaffold of thickness easily exceeding one centimeter. The manufacturing involves a solution of poly(ε-caprolactone) in DMF/DCM system. The aim is to establish parameters for electrospinning in order to characterize these 3D scaffolds and, establish whether such scaffolds are potentially interesting for bone regeneration.
authors: Institut National de la Santé et de la Recherche Médicale, Unité 977, Strasbourg, France.
authors: Sandy
authors: S
authors: Eap
authors: Alice
authors: A
authors: Ferrand
authors: Carlos Mendoza
authors: CM
authors: Palomares
authors: Anne
authors: A
authors: Hébraud
authors: Jean-François
authors: JF
authors: Stoltz
authors: Didier
authors: D
authors: Mainard
authors: Guy
authors: G
authors: Schlatter
authors: Nadia
authors: N
authors: Benkirane-Jessel
mesh_terms: D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; C016240:polycaprolactone