title: Short-term presynaptic plasticity.
abstract: Different types of synapses are specialized to interpret spike trains in their own way by virtue of the complement of short-term synaptic plasticity mechanisms they possess. Numerous types of short-term, use-dependent synaptic plasticity regulate neurotransmitter release. Short-term depression is prominent after a single conditioning stimulus and recovers in seconds. Sustained presynaptic activation can result in more profound depression that recovers more slowly. An enhancement of release known as facilitation is prominent after single conditioning stimuli and lasts for hundreds of milliseconds. Finally, tetanic activation can enhance synaptic strength for tens of seconds to minutes through processes known as augmentation and posttetantic potentiation. Progress in clarifying the properties, mechanisms, and functional roles of these forms of short-term plasticity is reviewed here.
authors: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Wade G
authors: WG
authors: Regehr
mesh_terms: D000818:Animals; D006801:Humans; D009473:Neuronal Plasticity; D017729:Presynaptic Terminals / Q000502:physiology*