title: The correlation between CD4+ T-lymphocyte count and tuberculosis form in TB-HIV coinfected patients in Indonesia.
abstract: OBJECTIVE
  to find whether there is a correlation between CD4+ count and TB form in TB-HIV Coinfected patients in Indonesia.
  
  
  METHODS
  this is a cross-sectional study of the TB-HIV patients at National HIV Center POKDISUS, Cipto Mangunkusumo Hospital in 2008-2011. We classified TB form as pulmonary TB, extrapulmonary TB, milliary TB, and combination form. The data were analyzed by Spearman and lambda correlation test. We also did partial correlation test to eliminate some counfounding factors, including demography and clinical characteristics, that had been determinated before.
  
  
  RESULTS
  there were 122 TB-HIV patients (aged median 31 [18-34], 80% male) included in this study. The most common TB form was pulmonary TB (71.2%), then extrapulmonary TB (7.4%), the combined type (18.9%), and milliary TB (2.5%). Median of CD4+ count was 40 cells/mL (IQR 17.5-100.6). There was a very weak correlation between CD4+ count and TB form in TB-HIV patients in Indonesia (r=0.185; p=0.042). The other factor that also showed a significant correlation to TB form is HIV staging (r=0.289; p=0.001). After adjusting those factors, we found an increase on correlation between CD4+ count and TB form (r=0.353; p=0.000).
  
  
  CONCLUSIONS
  there was a correlation between CD4+ count and TB form in TB-HIV patients in Indonesia, but in a very weak correlation.
authors: Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital. Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia. xilefchikita@hotmail.com
authors: Felix C
authors: FC
authors: Fredy
authors: Frans
authors: F
authors: Liwang
authors: Rudy
authors: R
authors: Kurniawan
authors: Anna Uyainah
authors: AU
authors: Nasir
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007214:Indonesia; D008297:Male; D018709:Statistics, Nonparametric; D014376:Tuberculosis / Q000145:classification* / Q000276:immunology*; D014391:Tuberculosis, Miliary / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology; D055815:Young Adult