title: Oncocytic-type intraductal papillary mucinous neoplasm (IPMN)-derived invasive oncocytic pancreatic carcinoma with brain metastasis - a case report.
abstract: Pancreatic cancer is a lethal disease without effective treatments at present. It ranks as s as 4th and 5th in cancer-related mortality in the western countries and worldwide. Locally advanced pancreatic duct carcinoma (PDAC) and metastatic PDAC, usually found the metastases over liver, peritoneum, or lung, have been shown to be with dismal prognosis. Brain metastasis is a rare entity and most cases reported before were found post-mortem. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) has been deemed as a precursor of PDAC with very slow progression rate. Here we reported a case diagnosed with IPMN-derived PDAC with brain metastasis. After surgeries for PDAC and brain metastasis, subsequent chemotherapy and radiotherapy were also given. One and half year after surgery, this patient is still living with good performance status, which may warrant individualization of therapeutic strategy for PDAC with only brain metastasis.
authors: General Surgery Department, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung 204, Taiwan.
authors: Kun-Chun
authors: KC
authors: Chiang
authors: Chi-Chang
authors: CC
authors: Yu
authors: Jim-Ray
authors: JR
authors: Chen
authors: Yu-Ting
authors: YT
authors: Huang
authors: Cheng-Cheng
authors: CC
authors: Huang
authors: Chun-Nan
authors: CN
authors: Yeh
authors: Chien-Sheng
authors: CS
authors: Tsai
authors: Li-Wei
authors: LW
authors: Chen
authors: Hsien-Cin
authors: HC
authors: Chen
authors: Jun-Te
authors: JT
authors: Hsu
authors: Cheng-Hsu
authors: CH
authors: Wang
authors: Huang-Yang
authors: HY
authors: Chen
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy