title: Low Grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Clinicopathological Factors Associated with Helicobacter pylori Eradication and Tumor Regression.
abstract: OBJECTIVE
  Eradication of Helicobacter pylori is widely accepted as initial therapy for low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, approximately 20% of patients with this disease are not responsive to H. pylori eradication therapy. The aim of this study was to assess remission and relapse rates of low-grade gastric MALT lymphoma after H. pylori eradication and identify the clinical factors that affect remission.
  
  
  METHODS
  Thirty-nine patients diagnosed with gastric MALT lymphoma (May 2003 to May 2010) were retrospectively analyzed.
  
  
  RESULTS
  Of the 39 patients, 30 (77%) had a H. pylori infection. There were 35/39 (90%) patients with stage I. Among stage I, 25 patients with the infection underwent eradication therapy and 22/25 (88%) achieved remission. The total regression rate with eradication only in stage I was 24/28 (86%). The median time to remission was 98 days (range, 22 to 397 days). Age, tumor location, invasion depth, H. pylori burden, and severity of mononuclear leukocyte and neutrophil infiltration were not related to remission. However, patients with less neutrophil infiltration were more likely to achieve a successful first H. pylori eradication (p=0.049).
  
  
  CONCLUSIONS
  The results show that the rate of low-grade gastric MALT lymphoma regression (86%) with H. pylori eradication alone was higher than that in Western studies (77.8%) and that neutrophil infiltration was inversely related to success of the first H. pylori eradication procedure.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Yoon Jin
authors: YJ
authors: Choi
authors: Dong Ho
authors: DH
authors: Lee
authors: Ji Yeon
authors: JY
authors: Kim
authors: Ji Eun
authors: JE
authors: Kwon
authors: Jae Yeon
authors: JY
authors: Kim
authors: Hyun Jin
authors: HJ
authors: Jo
authors: Cheol Min
authors: CM
authors: Shin
authors: Hyun Young
authors: HY
authors: Kim
authors: Young Soo
authors: YS
authors: Park
authors: Nayoung
authors: N
authors: Kim
authors: Hyun Chae
authors: HC
authors: Jung
authors: In Sung
authors: IS
authors: Song