title: Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide.
abstract: A water-soluble polysaccharide (APP), with a molecular weight of 4.6×10(4) Da, was isolated from Andrographis paniculata and gas chromatography (GC) analysis showed APP was composed of galactose, mannose, fucose, arabinose and rhamnose with molar ratios of 15.4:2.5:4.3:1.5:1.6. The synergetic effect of APP in combination with andrographolide on renal complication in streptozotocin (STZ) induced diabetic mice was investigated. Wistar rats were made diabetic by injection of STZ, and APP and/or andrographolide was administered to diabetic mice for continuous two weeks. APP plus andrographolide not only increased the body weight and creatinine clearance rate (Ccr), but also decreased the levels of serum creatinine, serum urea nitrogen, urinary albumin excretion (UAE), serum urea and blood glucose in diabetic rats, as well as the relative kidney weight. In summary, APP plus andrographolide can improve the metabolic abnormalities of diabetic mice and prevent or delay the progression of diabetic renal complications, which may be useful as a therapeutic agent for inhibiting the progression of diabetic nephropathy.
authors: Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
authors: Jie
authors: J
authors: Xu
authors: Zhanting
authors: Z
authors: Li
authors: Min
authors: M
authors: Cao
authors: Han
authors: H
authors: Zhang
authors: Jifeng
authors: J
authors: Sun
authors: Jie
authors: J
authors: Zhao
authors: Qiang
authors: Q
authors: Zhou
authors: Zhifen
authors: Z
authors: Wu
authors: Lianjia
authors: L
authors: Yang
mesh_terms: D000419:Albuminuria / Q000188:drug therapy; D035685:Andrographis / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D055598:Chemical Phenomena; D003404:Creatinine / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D004224:Diterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014508:Urea / Q000097:blood; D014867:Water / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D004224:Diterpenes; D011134:Polysaccharides; D014867:Water; C030419:andrographolide; D014508:Urea; D003404:Creatinine