title: Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats.
abstract: This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.
authors: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan 250021, Shandong, People's Republic of China.
authors: Ling
authors: L
authors: Guo
authors: Yong Le
authors: YL
authors: Sun
authors: Ai Hong
authors: AH
authors: Wang
authors: Chong En
authors: CE
authors: Xu
authors: Meng Yuan
authors: MY
authors: Zhang
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins; D031174:Atractylodes / Q000737:chemistry*; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry*; D000068103:Serine-Arginine Splicing Factors; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D051017:Apoptosis Regulatory Proteins; D002316:Cardiotonic Agents; D002352:Carrier Proteins; C489013:DIABLO protein, rat; D007155:Immunologic Factors; D024101:Mitochondrial Proteins; D009419:Nerve Tissue Proteins; D010936:Plant Extracts; D011134:Polysaccharides; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C490770:Tra2b protein, rat; D000068103:Serine-Arginine Splicing Factors; C505410:Casp3 protein, rat; D053148:Caspase 3