title: Application of Jatropha curcas L. seed oil (Euphorbiaceae) and microcurrent on the healing of experimental wounds in Wistar rats.
abstract: OBJECTIVE
  To investigate the effects of Jatropha curcas L. seed oil and microcurrent stimulation on the healing of wounds experimentally induced in Wistar rats.
  
  
  METHODS
  Forty-eight animals were divided into four groups: (A) control; (B) treated with microcurrent (10 µA/2 min); (C) treated with J. curcas seed oil, and (D) treated with J. curcas seed oil plus microcurrent. Tissues samples were obtained two, six, ten and 14 days after injury and submitted to structural and morphometric analyses.
  
  
  RESULTS
  The animals of groups A and C showed similar responses in terms of repair area, total number of cells, number of newly formed blood vessels, epithelial thickness, and percentage of area occupied by mature collagen fibers. Significant differences in all parameters analyzed were observed between animals of groups B and D and the control 10 and 14 days after experimentally induced injury. The morphometric data confirmed the structural findings
  
  
  CONCLUSIONS
  The application of J. curcas seed oil alone was not effective on experimental wound healing when compared to control, but microcurrent application alone or combined with the oil exerted significant differences in the parameters studied. These findings suggest that the positive results were due to microcurrent stimulation.
authors: School of Pharmacy, Herminio Ometto University Center, UNIARARAS, Araras, SP, Brazil.
authors: José Roberto
authors: JR
authors: Passarini Junior
authors: Fernanda Oliveira de Gaspari de
authors: FO
authors: Gaspi
authors: Lia Mara Grosso
authors: LM
authors: Neves
authors: Marcelo Augusto Marreto
authors: MA
authors: Esquisatto
authors: Gláucia Maria Tech dos
authors: GM
authors: Santos
authors: Fernanda Aparecida Sampaio
authors: FA
authors: Mendonça
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D031286:Jatropha; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D010938:Plant Oils