title: Structural elucation of a novel impurity in rifaximin.
abstract: Rifaximin is a semi-synthetic rifamycin derivate. It acts on RNA polymerase of the subunit of DNA beta-2 in bacteria to restrain synthesis of RNA leading to antibacterial activity. The purpose of this study was to analyse the structure of the prepared impurity a. We found that the impurity a is the isomeride of impurity G defined in the European Pharmacopoeia.
authors: Pharmacy Department of Medical Institute of Nanchang University, Nanchang, China. dxy885511@126.com
authors: Liuchao
authors: Maixi
authors: Wangchao
authors: Chunpeng
authors: C
authors: Wan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002725:Chloroform; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012294:Rifamycins / Q000737:chemistry*; D000078262:Rifaximin; D012997:Solvents
chemical_list: D000890:Anti-Infective Agents; D012294:Rifamycins; D012997:Solvents; D002725:Chloroform; D000078262:Rifaximin