title: Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt.
abstract: The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer (serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection) in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity (100%). We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential.
authors: Department of Experimental and Clinical Surgery, Medical Research Institute, University of Alexandria, Alexandria, Egypt. medhatanwar@gmail.com
authors: M M
authors: MM
authors: Anwar
authors: A I
authors: AI
authors: Youssef
authors: M I
authors: MI
authors: Sheta
authors: A
authors: A
authors: Zaki
authors: N R
authors: NR
authors: Bernaba
authors: M A
authors: MA
authors: El-Toukhi
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000097:blood*; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000378:metabolism; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D004534:Egypt; D005260:Female; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000175:diagnosis; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D005755:Gastrins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human