title: Genome organizing function of SATB1 in tumor progression.
abstract: When cells change functions or activities (such as during differentiation, response to extracellular stimuli, or migration), gene expression undergoes large-scale reprogramming, in cell type- and function-specific manners. Large changes in gene regulation require changes in chromatin architecture, which involve recruitment of chromatin remodeling enzymes and epigenomic modification enzymes to specific genomic loci. Transcription factors must also be accurately assembled at these loci. SATB1 is a genome organizer protein that facilitates these processes, providing a nuclear architectural platform that anchors hundreds of genes, through its interaction with specific genomic sequences; this activity allows expression of all these genes to be regulated in parallel, and enables cells to thereby alter their function. We review and describe future perspectives on SATB1 function in higher-order chromatin structure and gene regulation, and its role in metastasis of breast cancer and other tumor types.
authors: Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA. tkohwi-shigematsu@lbl.gov
authors: Terumi
authors: T
authors: Kohwi-Shigematsu
authors: Krzysztof
authors: K
authors: Poterlowicz
authors: Ellen
authors: E
authors: Ordinario
authors: Hye-Jung
authors: HJ
authors: Han
authors: Vladimir A
authors: VA
authors: Botchkarev
authors: Yoshinori
authors: Y
authors: Kohwi
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D018450:Disease Progression; D044127:Epigenesis, Genetic / Q000235:genetics; D005260:Female; D015894:Genome, Human / Q000502:physiology; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics*
chemical_list: D002843:Chromatin; D036961:Matrix Attachment Region Binding Proteins; C076189:SATB1 protein, human