title: Correlation between fecal concentrations of ciprofloxacin and fecal counts of resistant Enterobacteriaceae in piglets treated with ciprofloxacin: toward new means to control the spread of resistance?
abstract: We assessed in a piglet model the relationship between fecal ciprofloxacin concentrations and ciprofloxacin-resistant Enterobacteriaceae counts. Twenty-nine piglets were orally treated with placebo or with 1.5 or 15 mg ciprofloxacin/kg of body weight/day from day 1 (D1) to D5. Areas under the curve (AUC) of concentrations increased sharply with dose and correlated positively with AUC of resistant bacteria log counts between D1 and D9. Removing residual colonic quinolones could help to control the emergence of resistance in fecal flora.
authors: University Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors: Thu Thuy
authors: TT
authors: Nguyen
authors: Elisabeth
authors: E
authors: Chachaty
authors: Clarisse
authors: C
authors: Huy
authors: Carole
authors: C
authors: Cambier
authors: Jean
authors: J
authors: de Gunzburg
authors: France
authors: F
authors: Mentré
authors: Antoine
authors: A
authors: Andremont
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D058491:Bacterial Load; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000254:growth & development; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D010919:Placebos; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D002939:Ciprofloxacin