title: Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI vs. Sperm Slow: a prospective, randomized trial.
abstract: OBJECTIVE
  To compare, in a strict, randomized way, the efficiency of two ready-to-use systems for hyaluronic acid (HA)-intracytoplasmic sperm injection (ICSI): an HA culture dish (PICSI Sperm Selection Device) and a viscous medium containing HA (Sperm Slow).
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  Medical center.
  
  
  METHODS
  Fifty subjects per treatment group (100 total).
  
  
  METHODS
  One hundred ICSI treatments were randomly carried out with PICSI or with Sperm Slow for sperm selection. Randomization was conducted with sealed envelopes. Intracytoplasmic sperm injection was performed by a single embryologist with 5 years' experience in HA-ICSI.
  
  
  METHODS
  
  
  
  METHODS
  good-quality embryo rate.
  
  
  METHODS
  oocyte fertilization, pregnancy and implantation rate, and the duration of the ICSI procedure.
  
  
  RESULTS
  The good-quality embryo rate was comparable between the two groups (58.5% with PICSI vs. 56% with Sperm Slow). Overall there were no statistically significant differences in secondary outcome measures except ICSI procedure duration, which was 3 minutes longer in the PICSI group.
  
  
  CONCLUSIONS
  Both PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa.
  
  
  BACKGROUND
  ISRCTN72668039.
authors: Reproductive Medicine Unit, GynePro Medical Centers, Bologna, Italy. l.parmegiani@gynepro.it
authors: Lodovico
authors: L
authors: Parmegiani
authors: Graciela Estela
authors: GE
authors: Cognigni
authors: Silvia
authors: S
authors: Bernardi
authors: Enzo
authors: E
authors: Troilo
authors: Stefania
authors: S
authors: Taraborrelli
authors: Alessandra
authors: A
authors: Arnone
authors: Antonio Manuel
authors: AM
authors: Maccarini
authors: Marco
authors: M
authors: Filicori
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
chemical_list: D006820:Hyaluronic Acid