title: Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits.
abstract: Cornus wilsoniana Wanger is a woody oil plant distributed in the south region of the Yellow River, China. Its oil has been taken as edible oil for over 100 y, and consumption of such oil is believed to prevent hyperlipidemia in Chinese folk recipe. This study has investigated the hypolipidemic effect of Cornus wilsoniana oil (CWO) in Sprague-Dawley rats. The results demonstrated that CWO could significantly decrease total cholesterol (TC), total triacylglycerol (TG), and low-density lipoprotein cholesterol (HDL-C) in serum, liver weight, hepatic TC, and TG. After analyzing the chemical constituents of CWO, we found that the content of unsaturated fatty acids (UFA) was very high (69.12%). Specially, the n-6 polyunsaturated fatty acids (PUFA), including linoleic acid, γ-linolenic acid, and 11,14-eicosadienoic acid, accounted very great proportion (38.86%). The high hypolipidemic activity of CWO might be attributed to the lipid-lowering functions of these polyunsaturated fatty acids. Molecular docking was further performed to study the binding model of fatty acids (FA) from CWO to a possible hypolipidemic target, peroxisome proliferator-activated receptor δ (PPARδ). The results showed that linoleic acid and γ-linolenic acid could bind PPARδ very well.
  
  
  CONCLUSIONS
  Cornus wilsoniana oil could be used as equilibrated dietary oil, not only having hypolipidemic function, but also helping to overcome essential fatty acids deficiency.
authors: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
authors: Jie
authors: J
authors: Fu
authors: Xue-Wei
authors: XW
authors: Zhang
authors: Kai
authors: K
authors: Liu
authors: Qing-Shan
authors: QS
authors: Li
authors: Li-Rong
authors: LR
authors: Zhang
authors: Xian-Hui
authors: XH
authors: Yang
authors: Zhi-Ming
authors: ZM
authors: Zhang
authors: Chang-Zhu
authors: CZ
authors: Li
authors: Yin
authors: Y
authors: Luo
authors: Zhen-Xiang
authors: ZX
authors: He
authors: Hai-Liang
authors: HL
authors: Zhu
mesh_terms: D000818:Animals; D002681:China; D008078:Cholesterol, LDL / Q000097:blood; D029768:Cornus / Q000737:chemistry*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D004537:Eicosanoic Acids / Q000097:blood; D005638:Fruit / Q000737:chemistry; D006949:Hyperlipidemias / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D019787:Linoleic Acid / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D047494:PPAR delta / Q000378:metabolism; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D017965:gamma-Linolenic Acid / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D004537:Eicosanoic Acids; D000960:Hypolipidemic Agents; D047494:PPAR delta; D010938:Plant Oils; D014280:Triglycerides; C015876:eicosa-11,14-dienoic acid; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid