title: [Erythrocytic enzymopathy in Uzbekistan].
abstract: Erythrocyte enzymes participate in the main interactions promoting utilization of glucose-glycolytic, pentosophosphate cycles and glutation system. In this report we study on erythrocyte G6PD deficiency which is the impairment related to the gender and expressed with development of acute drug-associated hemolytic anemia. Out of 13187 studied subjects 122 showed carrying of deficiency of erythrocyte G6PD activity, from them 98 (80.3%) subjects were male, and 24 (19.7%) female. As a whole, among the revealed in the population studies, and also verified in clinic of the persons with deficiency of erythrocyte G6PD there were marked different pathological phenotypes: hereditary nonspherecytary hemolytic anemia, acute drug-induced hemolytic anemia, asymptomatic gene carrying and, selected by us disease with few symptoms. As a whole, among the revealed in the population studies, and also verified in clinic of the persons with deficiency of erythrocyte G6PD there were marked different pathological phenotypes: hereditary nonspherecytary hemolytic anemia, acute drug-induced hemolytic anemia, asymptomatic gene carrying and, selected by us disease with few symptoms.
authors: S M
authors: SM
authors: Bakhramov
authors: K K
authors: KK
authors: Ashrabhodzhaeva
mesh_terms: D000483:Alleles; D000743:Anemia, Hemolytic / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D000746:Anemia, Hemolytic, Congenital Nonspherocytic / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D002353:Carrier State; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D016877:Oxidants / Q000009:adverse effects; D010641:Phenotype; D055553:Prescription Drugs / Q000009:adverse effects; D015995:Prevalence; D014610:Uzbekistan / Q000453:epidemiology
chemical_list: D016877:Oxidants; D055553:Prescription Drugs; D005954:Glucosephosphate Dehydrogenase