title: Ultrasound in the assessment of pulmonary fibrosis in connective tissue disorders: correlation with high-resolution computed tomography.
abstract: OBJECTIVE
  To investigate the correlation between ultrasound (US) B-lines and high-resolution computed tomography (HRCT) findings in the assessment of pulmonary fibrosis (PF) in patients with connective tissue disorders (CTD).
  
  
  METHODS
  Thirty-four patients with a diagnosis of CTD were included. Each patient underwent clinical examination, pulmonary function test (PFT), chest HRCT, and lung US by an experienced radiologist or rheumatologist. A second rheumatologist carried out US examinations to assess interobserver agreement. In each patient, US B-line lung assessment including 50 intercostal spaces (IS) was performed. For the anterior and lateral chest, the IS were the second to the fifth along the parasternal, mid-clavicular, anterior axillary, and medial axillary lines (the left fifth IS of the anterior and lateral chest was not performed because of the presence of the heart, which limits lung visualization). For the posterior chest, the IS assessed were the seventh to the eighth along the posterior-axillary and subscapular lines. The second to eighth IS were assessed in the paravertebral line. In each IS, the number of US B-lines under the transducer was recorded, summed, and graded according to the following semiquantitative scoring: grade 0 = normal (< 10 B-lines); grade 1 = mild (11 to 20 B-lines); grade 2 = moderate (21 to 50 B-lines); and grade 3 = marked (> 50 B-lines).
  
  
  RESULTS
  A total of 1700 IS in 34 patients were assessed. A significant linear correlation was found between the US score and the HRCT score (p < 0.001; correlation coefficient ρ = 0.875). A positive correlation was found between US B-line assessments and values of DLCO (p = 0.014). Both κ values and overall percentages of interobserver agreement showed excellent agreement.
  
  
  CONCLUSIONS
  Our study demonstrates that US B-line assessment may be a useful and reliable additional imaging method in the evaluation of PF in patients with CTD.
authors: Clinica Reumatologica, Università Politecnica delle Marche, Ospedale "C. Urbani", Via dei Colli 52, 60035 Jesi, Ancona, Italy. dr.gmarwin@gmail.com.
authors: Marika
authors: M
authors: Tardella
authors: Marwin
authors: M
authors: Gutierrez
authors: Fausto
authors: F
authors: Salaffi
authors: Marina
authors: M
authors: Carotti
authors: Alarico
authors: A
authors: Ariani
authors: Chiara
authors: C
authors: Bertolazzi
authors: Emilio
authors: E
authors: Filippucci
authors: Walter
authors: W
authors: Grassi
mesh_terms: D000368:Aged; D003240:Connective Tissue Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011859:Radiography; D012129:Respiratory Function Tests; D035441:Thoracic Wall / Q000000981:diagnostic imaging; D014463:Ultrasonography