title: Polycomb group proteins and their roles in regulating stem cell development.
abstract: Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators: PRC1 (polycomb repressive complex 1) and PRC2 (polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.
authors: Department of Histology and Embryology, Jilin Medical College, Jilin 132013, China.
authors: Bing-yang
authors: BY
authors: Huang
authors: Xiao-yan
authors: XY
authors: Pan
authors: Zhi-xin
authors: ZX
authors: Li
authors: Zheng-chao
authors: ZC
authors: Wang
authors: Yong-sheng
authors: YS
authors: Yu
authors: Zhao-hua
authors: ZH
authors: Dou
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism / Q000502:physiology; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism / Q000502:physiology; D063146:Polycomb-Group Proteins / Q000378:metabolism / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
chemical_list: D063146:Polycomb-Group Proteins; D063151:Polycomb Repressive Complex 2; D063150:Polycomb Repressive Complex 1