title: Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice.
abstract: The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P < 0.01). The result of tests of anti-GAD antibody suggested that FTY720 treatment could suppress the anti-GAD response.
authors: College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China; E-Mail:  lijianrong@mail.zjgsu.edu.cn.
authors: Xiaoqiang
authors: X
authors: Chen
authors: Sudan
authors: S
authors: Ye
authors: Shikang
authors: S
authors: Zhang
authors: Jianrong
authors: J
authors: Li
authors: Hongying
authors: H
authors: Zhu
authors: Gaoli
authors: G
authors: Zheng
authors: Yin
authors: Y
authors: Lu
authors: Haitong
authors: H
authors: Wan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D000068876:Fingolimod Hydrochloride; D005968:Glutamate Decarboxylase / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D051379:Mice; D016688:Mice, Inbred NOD; D011409:Propylene Glycols / Q000008:administration & dosage*; D013110:Sphingosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013154:Spleen / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine