title: Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation.
abstract: Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids.
authors: Department of Pharmaceutical Chemistry, Institute of Health Biosciences, Graduate School of The University of Tokushima, Tokushima, Japan. nem@ph.tokushima-u.ac.jp
authors: Hisao
authors: H
authors: Nemoto
authors: Ayato
authors: A
authors: Katagiri
authors: Masaki
authors: M
authors: Kamiya
authors: Tsuyoshi
authors: T
authors: Matsushita
authors: Hatsuhiko
authors: H
authors: Hattori
authors: Kosuke
authors: K
authors: Matsumura
authors: Tomohiro
authors: T
authors: Itou
authors: Tomoyuki
authors: T
authors: Kawamura
authors: Toshiyuki
authors: T
authors: Kita
authors: Hana
authors: H
authors: Nishida
authors: Naokatu
authors: N
authors: Arakaki
mesh_terms: D005990:Glycerol / Q000138:chemical synthesis / Q000737:chemistry*; D008928:Mitochondria / Q000378:metabolism; D000077185:Resveratrol; D012995:Solubility; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D013267:Stilbenes; D014867:Water; C041525:3,3',4,5'-tetrahydroxystilbene; D005990:Glycerol; D000077185:Resveratrol