title: Targeted genes and interacting proteins of hypoxia inducible factor-1.
abstract: Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost all nucleated mammalian cells. The fundamental process adapted to cellular oxygen alteration largely depends on the refined regulation on its alpha subunit, HIF-1α. Recent studies have unraveled expanding and critical roles of HIF-1α, involving in a multitude of developmental, physiological, and pathophysiological processes. This review will focus on the current knowledge of HIF-1α-targeting genes and its interacting proteins, as well as the concomitant functional relationships between them.
authors: Wei
authors: W
authors: Liu
authors: Shao-Ming
authors: SM
authors: Shen
authors: Xu-Yun
authors: XY
authors: Zhao
authors: Guo-Qiang
authors: GQ
authors: Chen