title: Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
abstract: We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.
authors: Ovarian Cancer Research Center; Perelman School of Medicine; University of Pennsylvania; Philadelphia, USA.
authors: Andrea
authors: A
authors: Facciabene
authors: Stephen
authors: S
authors: Santoro
authors: George
authors: G
authors: Coukos