title: Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche.
abstract: Hematopoietic stem cells (HSCs) are characterized with long-term self-renewal and multi-lineage differentiation. HSCs preferentially reside in osteoblastic niche that is hierarchically organized so as to exactly regulate HSCs properties and maintain organism hematopoietic homeostasis. Hematopoietic stem cell-mesenchymal stem cell pairings share stem cell niches in adult bone marrow under immune-humoral-neural regulation. Here, we review the hierarchical HSC osteoblastic niche in terms of its localization, composition, function, and multi-layer regulation systems.
authors: Center for Clinical Molecular Medicine, Chongqing Medical University, Chongqing 400014, China.
authors: Hongxu
authors: H
authors: Wang
authors: Penghui
authors: P
authors: Zhang
authors: Lin
authors: L
authors: Liu
authors: Lin
authors: L
authors: Zou
mesh_terms: D000328:Adult; D000818:Animals; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D055153:Stem Cell Niche / Q000502:physiology*