title: Peripheral ameloblastoma of the lower molar gingiva: a case report and immunohistochemical study.
abstract: Peripheral ameloblastoma (PA) is a rare extraosseous odontogenic tumor with histological characteristics similar to those of the common intraosseous ameloblastoma. Two questions regarding PA remain: its histogenic origin and how to differentiate between PA and intraoral basal cell carcinoma. We describe a patient with PA. The result of immunohistochemistry showed cytokeratin (CK) 7-, CK14+, CK19+, AE1/AE3+, CAM5.2-, 34 β E12+, epithelial membrane antigen-, Ber-EP4-, p53-, p63+, and low Ki-67, that was similar to those of 4 cases of intraosseous ameloblastoma. Our results suggest that a PA originates from odontogenic epithelial remnants, rather than from the oral epithelium.
authors: Department of Oral and Maxillofacial Surgery Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. hisashi@tokai-u.jp
authors: Hisashi
authors: H
authors: Kato
authors: Yoshihide
authors: Y
authors: Ota
authors: Masashi
authors: M
authors: Sasaki
authors: Kazunari
authors: K
authors: Karakida
authors: Akihiro
authors: A
authors: Kaneko
authors: Yasutomo
authors: Y
authors: Sekido
authors: Keiichi
authors: K
authors: Tsukinoki
mesh_terms: D000564:Ameloblastoma / Q000175:diagnosis* / Q000378:metabolism*; D017920:Antiporters / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000378:metabolism; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008963:Molar; D018396:Mucin-1 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D000951:Antigens, Neoplasm
chemical_list: D017920:Antiporters; D014408:Biomarkers, Tumor; D007633:Keratins; D019394:Ki-67 Antigen; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53; C495901:TP53 protein, human; C115012:human epithelial antigen-125; D000951:Antigens, Neoplasm