title: 11C-methionine uptake correlates with combined 1p and 19q loss of heterozygosity in oligodendroglial tumors.
abstract: OBJECTIVE
  Oligodendroglial tumors with 1p/19q LOH are known to show longer patient survival than those without 1p/19q LOH, but the reason for this clinical difference has not been elucidated, to our knowledge. This study was designed to clarify whether uptake of MET correlates with 1p/19q LOH of oligodendroglial tumors.
  
  
  METHODS
  This study included 102 consecutive patients with supratentorial WHO grade II and III oligodendroglial tumors (39 oligoastrocytic and 63 oligodendroglial tumors) that were resected and diagnosed between January 2008 and August 2011 at Tokyo Women's Medical University Hospital. These patients underwent MET PET T/N ratio measurement before treatment. T/N ratios were calculated by dividing the maximum SUV for the tumor by the mean SUV of the contralateral normal frontal cortex. After surgery, FISH for resected tissues was used to determine 1p/19q LOH.
  
  
  RESULTS
  The mean T/N ratio of tumors with 1p/19q LOH was significantly greater than that of tumors without 1p/19q LOH (P = .0166). The threshold T/N ratio value of 2.46 was found to correlate significantly with 1p/19q LOH by univariate (P = .0011) and multivariate analyses (P = .0209) in all tumors.
  
  
  CONCLUSIONS
  The T/N ratio on MET PET might be a useful aid to the diagnosis of 1p/19q LOH. Our data add new information on the biology and imaging characteristics of oligodendroglial tumors with 1p/19q LOH.
authors: Department of Neurosurgery and Faculty of Advanced Techno-Surgery, Tokyo Women's Medical University, Tokyo, Japan. taiichis@gmail.com
authors: T
authors: T
authors: Saito
authors: T
authors: T
authors: Maruyama
authors: Y
authors: Y
authors: Muragaki
authors: M
authors: M
authors: Tanaka
authors: M
authors: M
authors: Nitta
authors: J
authors: J
authors: Shinoda
authors: T
authors: T
authors: Aki
authors: H
authors: H
authors: Iseki
authors: K
authors: K
authors: Kurisu
authors: Y
authors: Y
authors: Okada
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008875:Middle Aged; D009836:Oligodendroglia / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D011859:Radiography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D008715:Methionine; C038344:methionine methyl ester