title: Serum levels of 25-hydroxy-vitamin D3 among sun-protected outdoor workers in Israel.
abstract: The objective of this study was to evaluate the effect of reduced sun exposure of outdoor workers on vitamin D status using different modalities of sun protection, for primary prevention of skin cancer. 25-OH-D3 measurements were performed in two successive winters, 8 (interim) and 20 months after initiation of the study, in three groups of male outdoor workers, enrolled in either a complete, partial or minimal sun protection program. Ambient solar UVB radiation was monitored simultaneously. No intragroup or intergroup differences were observed between the interim- and postintervention measurements of mean 25-OH-D3, which were close to 30 ng mL(-1). Significant risk factors for postintervention 25-OH-D3 levels >33.8 ng mL(-1) (a surrogate for reduced sun protection) were: previous sunburn episodes (OR 2.5; 95% CI 1.01-6.3; P=0.05) and younger age (OR 0.92; 95 CI 0.86-0.98; P=0.009). Outdoor workers of Western, compared with those of Eastern paternal origin had a borderline significant risk (OR 2.4; 95% CI 0.9-6.3; P=0.07). A borderline significant effect (OR 2.9; 95% CI 0.97-10.1; P=0.085) was also noted for those in the minimal intervention group. In conclusion, sun protection among outdoor workers following a successful intervention did not suppress mean winter 25-OH-D3.
authors: Department of Dermatology, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel. esaz1@post.tau.ac.il
authors: Esther
authors: E
authors: Azizi
authors: Felix
authors: F
authors: Pavlotsky
authors: Avraham
authors: A
authors: Kudish
authors: Pazit
authors: P
authors: Flint
authors: Arie
authors: A
authors: Solomon
authors: Yehuda
authors: Y
authors: Lerman
authors: Bernice
authors: B
authors: Oberman
authors: Siegal
authors: S
authors: Sadetzki
mesh_terms: D000328:Adult; D000375:Aging; D002112:Calcifediol / Q000097:blood*; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016273:Occupational Exposure; D016017:Odds Ratio; D013471:Sunburn / Q000517:prevention & control; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013473:Sunscreening Agents; D002112:Calcifediol