title: Chronic exercise promotes alterations in the neuroendocrine profile of elderly people.
abstract: Aging and physical inactivity are 2 factors that favour the development of cardiovascular disease, metabolic syndrome, obesity, and diabetes. In contrast, adopting a habitual moderate exercise routine may be a nonpharmacological treatment alternative for neuroendocrine aging disorders. We aimed to assess the effects of moderate exercise training on the metabolic profiles of elderly people with sedentary lifestyles. Fourteen sedentary, healthy, elderly male volunteers participated in a moderate training regimen for 60 min/day, 3 days/week for 24 weeks at a work rate equivalent to their ventilatory aerobic threshold. The environment was maintained at a temperature of 23±2°C, with a humidity of 60±5%. Blood samples for analysis were collected at 3 intervals: at baseline (1 week before training began), and 3 and 6 months after training. The training promoted increased aerobic capacity (relative VO(2), and time and velocity to VO(2)max; (p<0.05)) and reduced serum α-MSH (p<0.05) after 3 months of training when compared with the baseline data. In addition, serum thyroid hormone (T3 and T4) was reduced after 6 months of training compared with baseline levels. Our results demonstrate that a moderate exercise training protocol improves the metabolic profile of older people, and metabolic adaptation is dependent on time.
authors: Centro de Estudo em Psicobiologia do Exercício, São Paulo, Brazil.
authors: E S
authors: ES
authors: Alves
authors: H S
authors: HS
authors: Souza
authors: J P P
authors: JP
authors: Rosa
authors: F S
authors: FS
authors: Lira
authors: G D
authors: GD
authors: Pimentel
authors: R V T
authors: RV
authors: Santos
authors: L M
authors: LM
authors: Oyama
authors: A R
authors: AR
authors: Damaso
authors: C M
authors: CM
authors: Oller do Nascimento
authors: V A R
authors: VA
authors: Viana
authors: R A
authors: RA
authors: Boscolo
authors: V
authors: V
authors: Grassmann
authors: M G
authors: MG
authors: Santana
authors: S
authors: S
authors: Tufik
authors: M T
authors: MT
authors: de Mello
mesh_terms: D000368:Aged; D015444:Exercise; D005247:Feeding Behavior; D006728:Hormones / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D009478:Neuropeptide Y / Q000097:blood; D010101:Oxygen Consumption; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D006728:Hormones; D020738:Leptin; D009478:Neuropeptide Y; D013963:Thyroid Hormones