title: Oxaliplatin, 5-fluorouracil and leucovorin (modified FOLFOX-6) as first-line chemotherapy for advanced gastric cancer patients with poor performance status.
abstract: This study was designed to retrospectively evaluate the efficacy and safety of modified FOLFOX-6 regimen in advanced gastric cancer (AGC) patients with poor performance status (PS). From January 2005 to August 2010, 23 AGC patients with poor PS who received mFOLFOX-6 as first-line chemotherapy were reviewed. Patients received 100 mg/m(2) oxaliplatin and 100 mg/m(2) leucovorin (LV) as a 2-h intravenous infusion on day 1, followed by 5-fluorouracil (5-FU) at 2000 mg/m(2) as a 46-h continuous infusion. A total of 22 patients received more than 3 cycles of chemotherapy and were evaluable for tumor response. Seven patients achieved partial response, giving an overall response rate of 31.8%. The median time to progression and overall survival were 3.5 and 9.2 months, respectively. Grade 3-4 hematological toxicities were noted: neutropenia in four patients (17.4%), anemia in two (8.7%) and thrombocytopenia in one (4.3%). Two patients developed febrile neutropenia and one of these patients succumbed to sepsis. Grade 3-4 gastrointestinal toxicities, such as nausea, vomiting and diarrhea were observed in less than 10% of patients. Peripheral neuropathy was observed in 9 patients (39.1%). In conclusion, the mFOLFOX-6 regimen for AGC patients with poor PS was effective with acceptable toxicity. Our results suggest that this regimen may be an effective option for these patients.
authors: Department of Internal Medicine Hallym Medical Center, Hallym University College of Medicine, Seoul 150-950.
authors: Hyeong Su
authors: HS
authors: Kim
authors: Jung Han
authors: JH
authors: Kim
authors: Hee Jun
authors: HJ
authors: Kim
authors: Hyun Joo
authors: HJ
authors: Jang
authors: Jin Bae
authors: JB
authors: Kim
authors: Ji Won
authors: JW
authors: Kim
authors: So Young
authors: SY
authors: Jung
authors: Byung Chun
authors: BC
authors: Kim
authors: Dae Hyun
authors: DH
authors: Yang
authors: Soah
authors: S
authors: Park
authors: Keong Ju
authors: KJ
authors: Kim
authors: Soon Il
authors: SI
authors: Lee
authors: Dae Young
authors: DY
authors: Zang