title: Sharp-needle intradermal fat grafting (SNIF).
abstract: BACKGROUND
  Reversing the effects of facial aging is best accomplished with a combination of techniques. Minimizing the appearance of fine wrinkles is an essential part of treatment, which can involve resurfacing, intradermal filler injections, or a combination of the two. The quest for the ideal filler material is ongoing, but intradermal fat injections can serve as an inexpensive and safe alternative to classic intradermal fillers.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the feasibility, validity, and safety of the sharp-needle intradermal fat grafting (SNIF) technique.
  
  
  METHODS
  The records of 250 consecutive patients treated over a 3-year period with the authors' SNIF technique were reviewed to evaluate the SNIF technique and its results, including complications.
  
  
  RESULTS
  Results were evaluated by clinical examination and patient photographs. Good improvement was achieved with SNIF, with results lasting more than 1 year, which exceeds the expected duration for resorbable dermal fillers (typically 3 to 6 months). No major complications occurred; the most common minor complications were bruising and swelling.
  
  
  CONCLUSIONS
  SNIF is a safe and effective alternative to classic resorbable dermal fillers for patients who can accept the minor discomfort involved in extracting fat from the donor site. The harvesting and injection techniques should be performed with precision to achieve favorable results and avoid complications.
authors: University Hospital, Brussels, Belgium.
authors: Assaf A
authors: AA
authors: Zeltzer
authors: Patrick L
authors: PL
authors: Tonnard
authors: Alexis M
authors: AM
authors: Verpaele
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D001530:Belgium; D003357:Cosmetic Techniques / Q000009:adverse effects / Q000295:instrumentation; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D009339:Needles; D012060:Rejuvenation; D012189:Retrospective Studies; D015595:Skin Aging; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000009:adverse effects / Q000379:methods; D014182:Transplantation, Autologous; D016896:Treatment Outcome