title: Introduction of multiphosphonate ligand to peptide nucleic acid for metal ion conjugation.
abstract: Peptide nucleic acid (PNA) is one of the most widely used synthetic DNA analogs. Conjugation of functional molecules to PNA is very effective to further widen its potential applications. For this purpose, here we report the synthesis of several ligand monomers and introduced them to PNA. These ligand-modified PNAs attract cerium ion and are useful for site-selective DNA hydrolysis. It should be noted that these ligands on PNA are also effective even under the conditions of invasion complex.
authors: Research Center for Advanced Science and Technology; The University of Tokyo, Tokyo, Japan.
authors: Yuichiro
authors: Y
authors: Aiba
authors: Yuta
authors: Y
authors: Honda
authors: Yue
authors: Y
authors: Han
authors: Makoto
authors: M
authors: Komiyama
mesh_terms: D001483:Base Sequence; D002563:Cerium / Q000737:chemistry* / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects; D008024:Ligands; D063065:Organophosphonates / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D002614:Chelating Agents; D008024:Ligands; D063065:Organophosphonates; D020135:Peptide Nucleic Acids; D002563:Cerium