title: Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters.
abstract: Optical dye-dilution techniques can quantify kinetic parameters in a region of tissue, but currently rely on a two-step process-spatial reconstruction of the dye concentration, repeated at every time-point, and subsequent kinetic analysis of the time-dependent change in dye concentration. Inaccuracies, in this approach, are due mainly to the ill-posed nature of the spatial reconstruction problem, which propagates into kinetic analysis and result in errors in extracted dynamic parameters. We present a hybrid kinetic deconvolution optical reconstruction algorithm, effectively combining optical reconstruction and model-independent kinetic analysis into a single inverse problem that is better posed. Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios.
authors: Department of Medical Biophysics, The University of Western Ontario, London, Ontario, N6A 3K7, Canada. jelliott@lawsonimaging.ca
authors: Jonathan T
authors: JT
authors: Elliott
authors: Mamadou
authors: M
authors: Diop
authors: Ting-Yim
authors: TY
authors: Lee
authors: Keith S
authors: KS
authors: Lawrence
mesh_terms: D000328:Adult; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007700:Kinetics; D008954:Models, Biological; D055620:Optical Phenomena