title: Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand.
abstract: Retrospective case series from Thailand have reported the presence of intra-abdominal abscesses in around half of patients with melioidosis, a much higher rate than our clinical experience would suggest. We performed a prospective, observational study of 230 adult patients with culture-confirmed melioidosis in which all patients underwent abdominal ultrasound. One or more abscesses were detected in the liver and/or spleen in 77 (33%) cases. These were often multiple (70%, 31/44 in hepatic abscesses and 88%, 50/57 in splenic abscesses) and clinically silent (27% of cases with abscesses presenting with abdominal pain). The mortality rate at 4 weeks post-discharge was lower in patients who were abscess-positive vs abscess-negative (10%, 8/77 vs 20%, 31/153).
authors: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Rajthevi, Bangkok, Thailand. rapeephan.maude@gmail.com
authors: Rapeephan R
authors: RR
authors: Maude
authors: Teerapon
authors: T
authors: Vatcharapreechasakul
authors: Pitchayanant
authors: P
authors: Ariyaprasert
authors: Richard J
authors: RJ
authors: Maude
authors: Maliwan
authors: M
authors: Hongsuwan
authors: Prayoon
authors: P
authors: Yuentrakul
authors: Direk
authors: D
authors: Limmathurotsakul
authors: Gavin C K W
authors: GC
authors: Koh
authors: Wipada
authors: W
authors: Chaowagul
authors: Nicholas P J
authors: NP
authors: Day
authors: Sharon J
authors: SJ
authors: Peacock
mesh_terms: D018784:Abdominal Abscess / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D015746:Abdominal Pain / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016957:Burkholderia pseudomallei / Q000472:pathogenicity*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008554:Melioidosis / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008875:Middle Aged; D011446:Prospective Studies; D013158:Splenic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D015996:Survival Rate; D013785:Thailand / Q000453:epidemiology; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents