title: Proteomics, genomics, and molecular biology in the personalized treatment of colorectal cancer.
abstract: Colorectal cancer develops and progresses from genetic and genomic changes that occur within and transforms the growth behavior of a normal colonic cell. Molecular tools have advanced enough to allow the scientific community to probe deeper into risk alleles within a population as well as into individual patient genetic data that can ascribe such a risk. Detected genetic and genomic changes from colorectal cancer can help determine a patient's prognosis, predict response to chemotherapy, and determine the approach to care with biological therapies. Utilizing stool, blood/plasma, and tumor tissue to obtain genetic, genomic, and pharmacokinetic information contribute to a person's profile to direct specific cancer care.
authors: Division of Gastroenterology, Department of Internal Medicine, University of Michigan, 3901 Taubman Center, SPC 5368, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5368, USA. jcarethe@umich.edu
authors: John M
authors: JM
authors: Carethers
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000628:therapy*; D023281:Genomics; D006801:Humans; D008967:Molecular Biology; D057285:Precision Medicine; D040901:Proteomics