title: Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives.
abstract: A series of N(2)-acyl isonicotinic acid hydrazides (1-17) was synthesized and tested for its in vitro antimycobacterial activity against Mycobacterium tuberculosis and the results indicated that the compound, isonicotinic acid N'- tetradecanoyl-hydrazide (12) was more active than the reference compound isoniazid. The results of antimicrobial activity of the synthesized compounds against S. aureus, B. subtilis, E. coli, C. albicans and A. niger indicated that compounds with dichloro, hydroxyl, tri-iodo and N(2)-tetradecanoyl substituent were the most active ones. The antiviral activity studies depicted that none of the tested compounds were active against DNA or RNA viruses. The multi-target QSAR model was found to be effective in describing the antimicrobial activity of N(2)-acyl isonicotinic acid hydrazides.
authors: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, India
authors: Vikramjeet
authors: V
authors: Judge
authors: Balasubramanian
authors: B
authors: Narasimhan
authors: Munish
authors: M
authors: Ahuja
authors: Dharmarajan
authors: D
authors: Sriram
authors: Perumal
authors: P
authors: Yogeeswari
authors: Erik
authors: E
authors: De Clercq
authors: Christophe
authors: C
authors: Pannecouque
authors: Jan
authors: J
authors: Balzarini
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D005658:Fungi / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007538:Isoniazid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D007538:Isoniazid