title: Incidence and clinical characteristics of periocular infantile hemangiomas.
abstract: OBJECTIVE
  To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas.
  
  
  METHODS
  The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed.
  
  
  RESULTS
  Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40-year period, yielding an incidence of 5.4 per 100,000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid.
  
  
  CONCLUSIONS
  In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
authors: Mayo Clinic College of Medicine, Rochester, MN, USA.
authors: Saba T
authors: ST
authors: Alniemi
authors: Gregory J
authors: GJ
authors: Griepentrog
authors: Nancy
authors: N
authors: Diehl
authors: Brian G
authors: BG
authors: Mohney
mesh_terms: D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005142:Eyelid Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006391:Hemangioma / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D008910:Minnesota / Q000453:epidemiology; D010331:Paternal Age; D047928:Premature Birth; D015995:Prevalence; D012189:Retrospective Studies