title: Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19-39 years old: an evaluation of health checkup data.
abstract: OBJECTIVE
  Japanese public health policies on the prevention of atherosclerotic diseases have focused on controlling obesity. The aim of this study was to assess the prevalence of abnormality in risk factors for atherosclerotic disease among young Japanese classified according to body mass index (BMI).
  
  
  METHODS
  Data were obtained from 359 men (mean age 32 ± 5 years) and 1,108 women (mean age 33 ± 4 years) between 2005 and 2010. Abnormal levels of aspartate aminotransferase, alanine aminotransferase, and/or gamma-glutamyltranspeptidase were considered to indicate liver dysfunction, and abnormal levels of low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and/or triglycerides were considered to indicate dyslipidemia. The cutoff points for high blood pressure (HBP) and hyperglycemia were set as a reference in the high-normal range.
  
  
  RESULTS
  No significant difference was observed in both sexes in all items among each year. In men, HBP (12.9 %), liver dysfunction (33.9 %), dyslipidemia (29.9 %), and hyperglycemia (2.7 %) were observed in the normal BMI group (18.5 < BMI ≤ 25 kg/m(2)). In women, these abnormalities were observed in both the normal BMI group and lean group.
  
  
  CONCLUSIONS
  Asymptomatic abnormalities, particularly liver dysfunction and dyslipidemia, were observed in a substantial percentage of subjects without obesity. Therefore, we recommend that the comprehensive public health policy should be directed at all individuals, including the non-obese group, for the early prevention/detection against atherosclerotic diseases.
authors: Sagamihara Public Health Center, 6-1-1 Fujimi, Chuo-ku, Sagamihara, Kanagawa 252-5277, Japan. kemal-s@umin.ac.jp
authors: Kemal
authors: K
authors: Sasaki
authors: Aya
authors: A
authors: Yoshida
authors: Hiroshi
authors: H
authors: Ohta
authors: Yoshiharu
authors: Y
authors: Aizawa
authors: Akiko
authors: A
authors: Kojima
authors: Hitomi
authors: H
authors: Chiba
authors: Shin
authors: S
authors: Mizuguchi
authors: Tatsunori
authors: T
authors: Ishidzuka
authors: Hiroshi
authors: H
authors: Goto
authors: Chiho
authors: C
authors: Uegaki
authors: Kyuhei
authors: K
authors: Kotake
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D050197:Atherosclerosis / Q000150:complications / Q000453:epidemiology*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000453:epidemiology*; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D007564:Japan / Q000453:epidemiology; D008099:Liver / Q000503:physiopathology*; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase