title: Distribution of delta opioid receptor-expressing neurons in the mouse hippocampus.
abstract: Delta opioid receptors participate to the control of chronic pain and emotional responses. Recent data also identified their implication in spatial memory and drug-context associations pointing to a critical role of hippocampal delta receptors. We examined the distribution of delta receptor-expressing cells in the hippocampus using fluorescent knock-in mice that express a functional delta receptor fused at its carboxyterminus with the green fluorescent protein in place of the native receptor. Colocalization with markers for different neuronal populations was performed by immunohistochemical detection. Fine mapping in the dorsal hippocampus confirmed that delta opioid receptors are mainly present in GABAergic neurons. Indeed, they are mostly expressed in parvalbumin-immunopositive neurons both in the Ammon's horn and dentate gyrus. These receptors, therefore, most likely participate in the dynamic regulation of hippocampal activity.
authors: Department of Human Genetics and Translational Medicine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/UdS, 1 Rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
authors: E
authors: E
authors: Erbs
authors: L
authors: L
authors: Faget
authors: G
authors: G
authors: Scherrer
authors: P
authors: P
authors: Kessler
authors: D
authors: D
authors: Hentsch
authors: J-L
authors: JL
authors: Vonesch
authors: A
authors: A
authors: Matifas
authors: B L
authors: BL
authors: Kieffer
authors: D
authors: D
authors: Massotte
mesh_terms: D000818:Animals; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000235:genetics; D006624:Hippocampus / Q000033:anatomy & histology / Q000166:cytology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D010320:Parvalbumins / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000235:genetics / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism; D050598:Vesicular Glutamate Transport Protein 1 / Q000378:metabolism; D050599:Vesicular Glutamate Transport Protein 2 / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D010320:Parvalbumins; D017465:Receptors, Opioid, delta; D050598:Vesicular Glutamate Transport Protein 1; D050599:Vesicular Glutamate Transport Protein 2; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D013004:Somatostatin; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2