title: Impact of gender and blood pressure on poststroke cognitive decline among older Latinos.
abstract: BACKGROUND
  Poststroke cognitive decline (PSCD) is an important consequence of stroke that may be more severe in women than in men. The existence of any gender differences in PSCD among Mexican Americans, and their potential mechanisms, such as blood pressure (BP), remain unknown. We assessed PSCD stratified on gender in older Mexican Americans and explored the influence of pre- and poststroke systolic BP on PSCD.
  
  
  METHODS
  Among 1576 nondemented, stroke-free adults 60 years of age or older when recruited between 1998 and 1999 in the Sacramento Area Latino Study on Aging (SALSA) cohort, we examined pre- and poststroke longitudinal changes in Spanish English Verbal Learning test scores (WL), a verbal memory test, and errors on the Modified Mini Mental State Examination (3MSE) scores, a global cognition test, stratified by gender, adjusting for baseline and time-varying covariates with linear mixed effects models.
  
  
  RESULTS
  We identified 151 adults (mean age 72 ± 8 years) with incident first-ever stroke during 10 years of follow-up. After adjustment for age, education, and time-varying depressive symptoms, 3MSE errors increased by 22% per year (95% confidence interval [CI] 6.8-36.7%) in men and 13.2% per year (95% CI 3.5-22.9%) in women over the poststroke period. Poststroke WL scores improved by 0.05 words per year (95% CI -0.24 to 0.33) in men and by 0.09 words per year (95% CI -0.16 to 0.34) in women. Results persisted after adjustment for time-varying systolic BP.
  
  
  CONCLUSIONS
  Among this population of older Mexican Americans, PSCD did not differ by gender. We found no evidence that systolic BP influenced PSCD in women or men.
authors: Division of General Medicine, University of Michigan Health System, and Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, Michigan; Veterans Affairs Health Services Research and Development Center of Excellence, Ann Arbor, Michigan; The Stroke ProgramUniversity of Michigan, Ann Arbor, Michigan. Electronic address: deblevin@umich.edu.
authors: Deborah A
authors: DA
authors: Levine
authors: Mary N
authors: MN
authors: Haan
authors: Kenneth M
authors: KM
authors: Langa
authors: Lewis B
authors: LB
authors: Morgenstern
authors: John
authors: J
authors: Neuhaus
authors: Anne
authors: A
authors: Lee
authors: Lynda D
authors: LD
authors: Lisabeth
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology; D001794:Blood Pressure / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D009483:Neuropsychological Tests; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D020521:Stroke / Q000150:complications* / Q000503:physiopathology / Q000523:psychology