title: Heterogeneous length of stay of hosts' movements and spatial epidemic spread.
abstract: Infectious diseases outbreaks are often characterized by a spatial component induced by hosts' distribution, mobility, and interactions. Spatial models that incorporate hosts' movements are being used to describe these processes, to investigate the conditions for propagation, and to predict the spatial spread. Several assumptions are being considered to model hosts' movements, ranging from permanent movements to daily commuting, where the time spent at destination is either infinite or assumes a homogeneous fixed value, respectively. Prompted by empirical evidence, here we introduce a general metapopulation approach to model the disease dynamics in a spatially structured population where the mobility process is characterized by a heterogeneous length of stay. We show that large fluctuations of the length of stay, as observed in reality, can have a significant impact on the threshold conditions for the global epidemic invasion, thus altering model predictions based on simple assumptions, and displaying important public health implications.
authors: Computational Epidemiology Laboratory, Institute for Scientific Interchange-ISI, Torino, Italy.
authors: Chiara
authors: C
authors: Poletto
authors: Michele
authors: M
authors: Tizzoni
authors: Vittoria
authors: V
authors: Colizza
mesh_terms: D000465:Algorithms; D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D003198:Computer Simulation; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D014943:Global Health / Q000706:statistics & numerical data; D006801:Humans; D008954:Models, Biological; D011156:Population Density; D011157:Population Dynamics; D011634:Public Health / Q000706:statistics & numerical data; D013997:Time Factors; D014195:Travel