title: Augmentation of the floor of the maxillary sinus with recombinant human bone morphogenetic protein-7: a pilot radiological and histological study in humans.
abstract: The aim of this study was to evaluate the quantity and quality of bony regeneration after we had used recombinant human bone morphogenetic protein-7 (rhBMP-7 to augment the floor of the maxillary sinus. Nine consecutive patients with bilateral posterior maxillary atrophy who required augmentation of the sinus for interposition of implants were treated simultaneously with rhBMP-7 (Osigraft) with deproteinised bone substitute (0.5 g on the test side) and with deproteinised bone alone (2.0 g on the control side). Computed tomographic images preoperatively, immediately postoperatively, and at 4 months postoperatively showed a mean (SD) postoperative gain of 10.8 (3.0) mm on the test side and of 10.2 (1.8) mm on the control side. Histological and histomorphometric analyses of biopsy specimens showed that there was significantly more new bone on the control side (19.9 (6.8)%) than on the test side (6.6 (4.8)%). In this pilot controlled trial of the use of rhBMP-7, histological analyses showed that it resulted in the formation of less bone than treatment with inorganic bovine hydroxyapatite.
authors: University of Bologna, Department of Oral and Dental Sciences, Via San Vitale 59, 40125 Bologna, Italy. corinaldesigiuseppe@virgilio.it
authors: Giuseppe
authors: G
authors: Corinaldesi
authors: Luigi
authors: L
authors: Piersanti
authors: Adriano
authors: A
authors: Piattelli
authors: Giovanna
authors: G
authors: Iezzi
authors: Francesco
authors: F
authors: Pieri
authors: Claudio
authors: C
authors: Marchetti
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D001284:Atrophy; D015519:Bone Density / Q000502:physiology; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods; D003094:Collagen; D015921:Dental Implants; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008437:Maxilla / Q000473:pathology; D008443:Maxillary Sinus / Q000187:drug effects / Q000473:pathology; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D059745:Piezosurgery / Q000379:methods; D010865:Pilot Projects; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: C525819:BMP7 protein, human; C106416:Bio-Gide; C077540:Bio-Oss; D055419:Bone Morphogenetic Protein 7; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen; D017886:Durapatite