title: [Relapsing non-traumatic intracerebral hemorrhage: study of 28 patients].
abstract: OBJECTIVE
  To characterize the clinical factors and prognosis and identify determinants of hemorrhage recurrence (HCR) in patients with acute non-traumatic intracerebral hemorrhage.
  
  
  METHODS
  Stroke patterns were studied in 28 consecutive recurrent non-traumatic intracerebral hemorrhage patients admitted to the Department of Neurology of the Sagrat Cor Hospital of Barcelona for a 19 year period. Demographic, risk factors, clinical, neuroimaging and outcome variables were analyzed and compared with patients with first-ever non-traumatic intracerebral hemorrhage (n=380) to identify predictors of hemorrhage recurrence. Significant variables were entered into a multivariate logistic regression analysis.
  
  
  RESULTS
  HCR accounted for 6.8% of all patients with acute consecutive non-traumatic intracerebral hemorrhages. The HCR were mostly lobar (67.9%). Other topographies include: thalamus (10.7%), capsule-ganglionar (7.1%), intraventricular (3.6%) and multiple topographies (10.7%). Although the HCR have poor prognosis, it is not worse compared to the first-ever intracerebral hemorrhages, both at the high hospital mortality (17.9 vs. 28.2%) as the low frequency of absence of limitation at discharge (3.6 vs. 6.1%). The clinical profile significantly associated with HCR was: valvular heart disease (odds ratio [OR] 5.32; 95% confidence interval [95% CI] 1.45-19.47), lobar topography (OR 3.53, 95% IC 1.53-8.13), and the presence of nausea and vomiting (OR 2.43, 95% IC 1.06-5.52).
  
  
  CONCLUSIONS
  HCR constitute less than one tenth of non-traumatic intracerebral hemorrhages and are most commonly located in the brain lobes. Although the prognosis is serious, this is no worse during the acute phase, than of the first-ever non-traumatic intracerebral hemorrhages. Clinical profiles were different in recurrent non-traumatic intracerebral hemorrhage patients when compared to first-ever non-traumatic intracerebral hemorrhage patients.
authors: Unidad de Enfermedades Vasculares Cerebrales, Servicio de Neurología, Capio-Hospital Universitari del Sagrat Cor, Universitat de Barcelona, Barcelona, España. aarboix@hscor.com
authors: Adrià
authors: A
authors: Arboix
authors: Joan
authors: J
authors: Massons
authors: Luís
authors: L
authors: García-Eroles
authors: Emili
authors: E
authors: Comes
authors: Cecilia
authors: C
authors: Targa
authors: Montserrat
authors: M
authors: Oliveres
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020785:Central Nervous System Vascular Malformations / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D003141:Communicable Diseases / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications / Q000453:epidemiology; D006402:Hematologic Diseases / Q000453:epidemiology; D017052:Hospital Mortality; D006786:Hospitals, Urban / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000453:epidemiology; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D019851:Thrombophilia / Q000188:drug therapy / Q000209:etiology; D014839:Vomiting / Q000453:epidemiology
chemical_list: D010975:Platelet Aggregation Inhibitors