title: Local deposition fractions of ultrafine particles in a human nasal-sinus cavity CFD model.
abstract: Ultrafine particle deposition studies in the human nasal cavity regions often omit the paranasal sinus regions. Because of the highly diffusive nature of nanoparticles, it is conjectured that deposition by diffusion may occur in the paranasal sinuses, which may affect the residual deposition fraction that leaves the nasal cavity. Two identical CFD models of a human nasal cavity, one with sinuses and one without, were reconstructed from CT-scans to determine the uptake of ultrafine particles. In general, there was little flow passing through the paranasal sinuses. However, flow patterns revealed that some streamlines reached the upper nasal cavity near the olfactory regions. These flow paths promote particle deposition in the sphenoid and ethmoid sinuses. It was found that there were some differences in the deposition fractions and patterns for 5 and 10 nm particles between the nasal-sinus and the nasal cavity models. This difference is amplified when the flow rate is decreased and at a flow rate of 4 L/min the maximum difference was 17%. It is suggested that evaluations of nanoparticle deposition should consider some deposition occurring in the paranasal sinuses especially if flow rates are of concern.
authors: School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Vic, Australia.
authors: Qin Jiang
authors: QJ
authors: Ge
authors: Kiao
authors: K
authors: Inthavong
authors: Ji Yuan
authors: JY
authors: Tu
mesh_terms: D000393:Air Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity; D019295:Computational Biology; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D008954:Models, Biological; D053758:Nanoparticles / Q000633:toxicity; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000378:metabolism*; D010256:Paranasal Sinuses / Q000033:anatomy & histology / Q000378:metabolism*; D010316:Particle Size; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D000393:Air Pollutants