title: Optimising the delivery of tubulin targeting agents through antibody conjugation.
abstract: Despite their side effect profile, there currently remains a heavy reliance on traditional cytotoxics and particularly tubulin targeting agents in cancer chemotherapy. To address this concern, significant progress has been made in the selective delivery of drugs to the tumour site. This review will examine the published data in support of the hypothesis that forming antibody conjugates of tubulin targeting agents is an effective approach towards their more effective delivery to the tumour site. Particular emphasis will be placed on the diversity of concepts under investigation, the efficacy of resultant conjugates, evidence of decreased resistance and the side effect profiles of the conjugates.
authors: School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
authors: Gary D
authors: GD
authors: Stack
authors: John J
authors: JJ
authors: Walsh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage* / Q000276:immunology*; D014404:Tubulin / Q000276:immunology*; D050257:Tubulin Modulators / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D018796:Immunoconjugates; D014404:Tubulin; D050257:Tubulin Modulators