title: Type-specific response to neoadjuvant chemotherapy: ovarian high-grade serous carcinoma versus colorectal mucinous carcinoma.
abstract: BACKGROUND
  Ovarian carcinomas are currently managed as a single entity with no stratification for histological type. The foundation of treatment is a combination of surgery and chemotherapy. Women who are not candidates for up-front debulking surgery, either because of performance status or widespread disease, are often offered neoadjuvant chemotherapy in an effort to shrink their tumour and make resection possible.
  
  
  METHODS
  A 76-year-old woman was treated with neoadjuvant platinum-based chemotherapy for advanced ovarian cancer. At interval debulking surgery, she was found to have a concurrent mucinous colorectal carcinoma that was essentially unaffected by her treatment.
  
  
  CONCLUSIONS
  This case serves as an in vivo demonstration of the greater resistance to platinum-based treatments of mucinous carcinomas than of the "typical" high-grade serous ovarian cancer.
authors: Division of Gynecologic Oncology, University of Calgary, Calgary AB.
authors: Sarah
authors: S
authors: Glaze
authors: Jill
authors: J
authors: Nation
authors: Martin
authors: M
authors: Köbel
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology / Q000628:therapy; D018284:Cystadenocarcinoma, Serous / Q000473:pathology / Q000628:therapy; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin