title: Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.
abstract: The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides. This methodology allows the convergent combination of readily available precursors in a regioselective manner and in excellent overall yields. This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds.
authors: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom. hy.donohoe@chem.ox.ac.uk
authors: Timothy J
authors: TJ
authors: Donohoe
authors: Ben S
authors: BS
authors: Pilgrim
authors: Geraint R
authors: GR
authors: Jones
authors: José A
authors: JA
authors: Bassuto
mesh_terms: D002384:Catalysis; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D007546:Isoquinolines; D007659:Ketones; D010165:Palladium