title: Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice.
abstract: In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice showed a significant decrease in mechanical threshold compared with the sham-operated mice, characterizing the development of mechanical allodynia. The selective and irreversible MAO-B inhibitor selegiline, at a dose sufficient to selectively inhibit MAO-B activity (10 mg/kg), showed an anti-allodynic effect from 0.5 to 6 h after incision. Likewise, partial sciatic nerve ligation submitted mice also developed mechanical allodynia, which was reversed by selegiline (10 mg/kg) from 2 to 6 h after treatment. In addition, a significant increase on striatal MAO-B activity was observed in neuropathic mice compared with the sham-operated animals, which was reversed by selegiline treatment. Taken together, our results showed that MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain.
authors: Laboratório de Neurotoxicidade e Psicofarmacologia, Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Avenida Roraima 1000, RS 97105-900, Santa Maria, Brazil.
authors: Jardel Gomes
authors: JG
authors: Villarinho
authors: Sara Marchesan
authors: SM
authors: Oliveira
authors: Cássia Regina
authors: CR
authors: Silva
authors: Thaíssa Nunes
authors: TN
authors: Cabreira
authors: Juliano
authors: J
authors: Ferreira
mesh_terms: D000818:Animals; D003010:Clorgyline / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D009437:Neuralgia / Q000188:drug therapy / Q000201:enzymology*; D011183:Postoperative Complications / Q000188:drug therapy / Q000201:enzymology*; D045442:Rotarod Performance Test; D012642:Selegiline / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline