title: Formal synthesis of 7-methoxymitosene and synthesis of its analog via a key PtCl2-catalyzed cycloisomerization.
abstract: A formal synthesis of 7-methoxymitosene is achieved via a key platinum-catalyzed cycloisomerization. The precursor for the Pt catalysis, a fully functionalized benzene intermediate, was prepared via a regioselective electrophilic bromination followed by a chemoselective Sonogashira cross-coupling. It underwent the PtCl2-catalyzed cycloisomerization smoothly despite its hindered and highly electron-rich nature. Analogs of 7-methoxymitosene can be accessed in an expedient manner by following a similar synthetic sequence.
authors: Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106, United States.
authors: Lianzhu
authors: L
authors: Liu
authors: Yanzhao
authors: Y
authors: Wang
authors: Liming
authors: L
authors: Zhang
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D017671:Platinum Compounds