title: Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper.
abstract: Homodyne detection can dramatically enhance measurement sensitivity for weak signals. In nonlinear optical microscopy it can make accessible a range of novel, intrinsic, contrast like nonlinear absorption and nonlinear phase contrast. Here a compact and rapid pulse shaper is developed, implemented, and demonstrated for homodyne detection in nonlinear microscopy with high-repetition rate mode-locked femtosecond lasers. With this method we generate two-photon absorption (TPA) and self-phase modulation images of gold nanostars in biological samples. Simultaneous imaging of two-photon luminescence and TPA also enables us to produce two-photon quantum yield images.
authors: Department of Physics, Duke University, Durham, North Carolina 27708, USA.
authors: Baolei
authors: B
authors: Li
authors: Kevin E
authors: KE
authors: Claytor
authors: Hsiangkuo
authors: H
authors: Yuan
authors: Tuan
authors: T
authors: Vo-Dinh
authors: Warren S
authors: WS
authors: Warren
authors: Martin C
authors: MC
authors: Fischer
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D053768:Metal Nanoparticles; D008853:Microscopy / Q000379:methods*; D017711:Nonlinear Dynamics; D055620:Optical Phenomena; D059629:Signal-To-Noise Ratio
chemical_list: D006046:Gold