title: Effects of EMD in combination with bone swaging and calcium phosphate bone cement on periodontal regeneration in one-wall intrabony defects in dogs.
abstract: OBJECTIVE
  Although the application of EMD is a widely accepted periodontal-regenerative therapy, its effects on noncontained intrabony defects are unpredictable because of the lack of a space-making property. The combined use of EMD and autogenous bone grafts reportedly stimulates significant periodontal regeneration in intrabony defects. The aim of the present study was to evaluate the effects of EMD in combination with bone swaging (BS) and injectable calcium phosphate bone cement (CPC), which was placed into the spaces between the grafted swaged bone and the proximal host bone, on periodontal healing in one-wall intrabony defects in dogs.
  
  
  METHODS
  One-wall intrabony defects (3 mm wide and 5 mm deep) were surgically created on the mesial and distal sides of the bilateral mandibular premolars in four dogs. The 16 defects were assigned to one of the following treatments: EMD only, BS only, EMD with BS (EMD + BS), or EMD with BS and CPC (EMD + BS + CPC). The animals were killed 8 wk after surgery for histologic evaluation.
  
  
  RESULTS
  The height of newly formed bone was significantly greater in the EMD + BS + CPC group (3.73 ± 0.30 mm) than in the BS-only (2.74 ± 0.33 mm; p < 0.05) and EMD + BS (2.88 ± 0.98 mm; p < 0.05) groups. The area of newly formed bone was significantly larger in the EMD + BS + CPC group (5.68 ± 1.66 mm(2)) than in the EMD-only (3.68 ± 0.33 mm(2); p < 0.05), BS-only (3.48 ± 1.26 mm(2); p < 0.05) and EMD + BS (3.38 ± 1.37 mm(2); p < 0.05) groups. The EMD-only (4.63 ± 0.42 mm), EMD + BS (4.67 ± 0.30 mm) and EMD + BS + CPC (4.78 ± 0.54 mm) groups showed significantly greater cementum formation than did the BS-only group (3.93 ± 0.56 mm; p < 0.05).
  
  
  CONCLUSIONS
  These results indicate that treatment with EMD + BS + CPC promotes favorable periodontal healing in one-wall intrabony defects in dogs.
authors: Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors: Y
authors: Y
authors: Shirakata
authors: T
authors: T
authors: Yoshimoto
authors: N
authors: N
authors: Takeuchi
authors: K
authors: K
authors: Taniyama
authors: K
authors: K
authors: Noguchi
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D016025:Bone Transplantation / Q000379:methods*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D025021:Cementogenesis / Q000187:drug effects; D003094:Collagen / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D003739:Dental Cementum / Q000187:drug effects / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D004846:Epithelial Attachment / Q000187:drug effects / Q000473:pathology; D008297:Male; D008334:Mandible / Q000601:surgery; D010012:Osteogenesis / Q000187:drug effects; D010513:Periodontal Ligament / Q000187:drug effects / Q000473:pathology; D019237:Tooth Cervix / Q000187:drug effects / Q000473:pathology; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D003094:Collagen