title: Amiodarone therapy: don't forget thyroid.
abstract: Amiodarone is an effective anti-arrhythmic agent for control of various life threatening ventricular tachyarrhythmias but may give Various side effects. Clinically relevant thyroid dysfunction is not uncommon during amiodarone therapy and is caused by iodide excess and inhibition of deiodinase activity. Amiodarone induced thyroid dysfunction varies from asymptomatic variation in thyroid function to clinically overt hypothyroidism and thyrotoxicosis. Prolonged elimination and half life and associated complications warrant for rational prescribing and long term follow up.
authors: Department of Radiology, The Agha Khan University Hospital (AKUH), Karachi Institute of Radiotherapy And Nuclear Medicine (KIRAN), Karachi, Pakistan.
authors: Maseeh-uz-Zaman
authors: Nosheen
authors: N
authors: Fatima
authors: Zafar
authors: Z
authors: Sajjad
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D013959:Thyroid Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D000889:Anti-Arrhythmia Agents; D013963:Thyroid Hormones; D000638:Amiodarone