title: Weekly nab-Paclitaxel in Metastatic Breast Cancer - Summary and Results of an Expert Panel Discussion.
abstract: Taxanes are regarded as the most effective single agents in the treatment of metastatic breast cancer (MBC). For conventional taxanes, crucial toxicities and impairments in clinical efficacy are related to solvents necessary because of the agents' hydrophobicity. The mandatory premedication with corticosteroids causes additional side effects. Nab-paclitaxel is a solvent-free colloidal suspension of paclitaxel and human serum albumin that exploits the physiological transport properties of albumin. It is registered as monotherapy with a recommended dose of 260 mg/m(2) every 3 weeks for the treatment of patients with MBC, who have failed a first-line treatment of metastatic disease and for whom a standard anthracycline treatment is not indicated. Clinical evidence is available for the registered 3-weekly administration and for alternative weekly schedules in first and further lines of therapy of patients with MBC. During an advisory board meeting, a group of 8 German breast cancer experts reviewed the clinical data of nab-paclitaxel in MBC and discussed how nab-paclitaxel could be used in clinical practice on the basis of the current data.
authors: Klinik für Gynäkologie und Geburtshilfe, Klinikum Offenbach, Germany.
authors: Christian
authors: C
authors: Jackisch
authors: Hans-Joachim
authors: HJ
authors: Lück
authors: Michael
authors: M
authors: Untch
authors: Joachim
authors: J
authors: Bischoff
authors: Volkmar
authors: V
authors: Müller
authors: Marcus
authors: M
authors: Schmidt
authors: Marc
authors: M
authors: Thill
authors: Marion
authors: M
authors: Kiechle