title: Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves.
abstract: In a crossover study, 5 calves were made acidotic by intermittent intravenous infusion of isotonic hydrochloric acid (HCl) over approximately 24 h. This was followed by rapid (4 h) or slow (24 h) correction of blood pH with isotonic sodium bicarbonate (NaHCO(3)) to determine if rapid correction of acidemia produced paradoxical cerebrospinal fluid (CSF) acidosis. Infusion of HCl produced a marked metabolic acidosis with respiratory compensation. Venous blood pH (mean ± S(x)) was 7.362 ± 0.021 and 7.116 ± 0.032, partial pressure of carbon dioxide (Pco(2), torr) 48.8 ± 1.3 and 34.8 ± 1.4, and bicarbonate (mmol/L), 27.2 ± 1.27 and 11 ± 0.96; CSF pH was 7.344 ± 0.031 and 7.240 ± 0.039, Pco(2) 42.8 ± 2.9 and 34.5 ± 1.4, and bicarbonate 23.5 ± 0.91 and 14.2 ± 1.09 for the period before the infusion of hydrochloric acid and immediately before the start of sodium bicarbonate correction, respectively. In calves treated with rapid infusion of sodium bicarbonate, correction of venous acidemia was significantly more rapid and increases in Pco(2) and bicarbonate in CSF were also more rapid. However, there was no significant difference in CSF pH. After 4 h of correction, CSF pH was 7.238 ± 0.040 and 7.256 ± 0.050, Pco(2) 44.4 ± 2.2 and 34.2 ± 2.1, and bicarbonate 17.8 ± 1.02 and 14.6 ± 1.4 for rapid and slow correction, respectively. Under the conditions of this experiment, rapid correction of acidemia did not provoke paradoxical CSF acidosis.
authors: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, USA.
authors: Saman
authors: S
authors: Abeysekara
authors: Gordon A
authors: GA
authors: Zello
authors: Katharina L
authors: KL
authors: Lohmann
authors: Jane
authors: J
authors: Alcorn
authors: Don L
authors: DL
authors: Hamilton
authors: Jonathan M
authors: JM
authors: Naylor
mesh_terms: D000138:Acidosis / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D018592:Cross-Over Studies; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D016014:Linear Models; D011897:Random Allocation; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
chemical_list: D002245:Carbon Dioxide; D017693:Sodium Bicarbonate