title: A recurrent fibronectin glomerulopathy in a renal transplant patient: a case report.
abstract: Fibronectin glomerulopathy (FNG) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end-stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end-stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of renal function four months after transplantation. Five allograft biopsies were underwent from one h to 12 months after the transplantation, including a biopsy 19 d after the transplantation, which revealed dense deposits suggesting fibronectin. A biopsy 134 d after the transplantation showed a feature of lobular glomerulonephritis corresponding FNG. The diagnosis was confirmed by IST4 positive and IST9 negative immunostaining together with typical fibrillary dense deposits in the mesangium and subendothelial spaces in electron microscopy. This is the first report of recurrent FNG in Japan.
authors: Department of Nephrology and Transplantation Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan. tzkr@nagoya2.jrc.or.jp
authors: Yasuhiro
authors: Y
authors: Otsuka
authors: Asami
authors: A
authors: Takeda
authors: Keiji
authors: K
authors: Horike
authors: Daijyo
authors: D
authors: Inaguma
authors: Norihiko
authors: N
authors: Goto
authors: Yoshihiko
authors: Y
authors: Watarai
authors: Kazuharu
authors: K
authors: Uchida
authors: Michael J
authors: MJ
authors: Mihatsch
authors: Kensuke
authors: K
authors: Joh
authors: Kunio
authors: K
authors: Morozumi
mesh_terms: D005260:Female; D005353:Fibronectins / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D012008:Recurrence
chemical_list: D005353:Fibronectins