title: Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children.
abstract: Low serum 25-hydroxyvitamin D [25 (OH) D] is common in healthy children particularly in blacks. However, serum 25 (OH) D concentrations for optimal bone turnover in children is unknown and few data exist that describe effects of increasing serum 25 (OH) D on bone turnover markers during puberty. The purpose of this study was to determine the relationships between serum 25 (OH) D and changes in serum 25 (OH) D and bone turnover in white and black pubertal adolescents. Bone turnover markers were measured in 318 healthy boys and girls from Georgia (34°N) and Indiana (40°N) who participated in a study of oral vitamin D(3) supplementation (0 to 4000 IU/d). Serum 25 (OH) D, osteocalcin, bone alkaline phosphatase, and urine N-telopeptide cross-links were measured at baseline and 12 weeks. Relationships among baseline 25 (OH) D and bone biomarkers, and between changes over 12 weeks were determined and tested for effects of race, sex, latitude, and baseline 25 (OH) D. Median 25 (OH) D was 27.6 ng/mL (n=318, range 10.1-46.0 ng/mL) at baseline and 34.5 ng/mL (n=302, range 9.7-95.1 ng/mL) at 12 weeks. Neither baseline nor change in 25 (OH) D over 12 weeks was associated with bone turnover. The lack of association was not affected by race, sex, latitude, or baseline serum 25 (OH) D. Serum 25 (OH) D in the range of 10-46 ng/mL appears to be sufficient for normal bone turnover in healthy black and white pubertal adolescents.
authors: Indiana University School of Medicine, Department of Medicine, Division of Endocrinology, 541 N. Clinical Drive, Indianapolis, IN 46202-5111, USA.
authors: Kathleen M
authors: KM
authors: Hill
authors: Emma M
authors: EM
authors: Laing
authors: Dorothy B
authors: DB
authors: Hausman
authors: Anthony
authors: A
authors: Acton
authors: Berdine R
authors: BR
authors: Martin
authors: George P
authors: GP
authors: McCabe
authors: Connie M
authors: CM
authors: Weaver
authors: Richard D
authors: RD
authors: Lewis
authors: Munro
authors: M
authors: Peacock
mesh_terms: D000293:Adolescent; D044383:Black People; D016723:Bone Remodeling; D005260:Female; D006801:Humans; D008297:Male; D011627:Puberty; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D044465:White People
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D