title: Antimycobacterial activity: a facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines.
abstract: A series of twelve dispiropyrrolidines were synthesized using [3+2]-cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1 μM. Compound 4'-[5-(4-fluorophenyl)pyridin-3-yl]-1'-methyldispiro[indan-2,2' pyrrolidine-3',2″-indan]-1,3,1″-trione (4b) was found to be the most active with MIC of 0.1215 and 5.121 μM, respectively.
authors: Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
authors: Ang Chee
authors: AC
authors: Wei
authors: Mohamed Ashraf
authors: MA
authors: Ali
authors: Yeong Keng
authors: YK
authors: Yoon
authors: Rusli
authors: R
authors: Ismail
authors: Tan Soo
authors: TS
authors: Choon
authors: Raju Suresh
authors: RS
authors: Kumar
authors: Natarajan
authors: N
authors: Arumugam
authors: Abdulrahman I
authors: AI
authors: Almansour
authors: Hasnah
authors: H
authors: Osman
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C576334:4'-(5-(4-fluorophenyl)pyridin-3-yl)-1'-methyldispiro(indan-2,2' pyrrolidine-3',2''-indan)-1,3,1''-trione; D000995:Antitubercular Agents; D011759:Pyrrolidines; D013141:Spiro Compounds; C032519:pyrrolidine