title: The relevance of antigen binding to the pathogenicity of lupus autoantibodies.
abstract: Although lupus autoantibodies provide diagnostic value, discordance between serum levels and nephritis poses mechanistic questions. Krishnan and co-workers report that only those that crossreact with basement membrane components produce immune deposits. Thus, other glomerular binding properties probably define where deposits form. Thereafter, Fc- and complement-mediated events influence disease expression. Clearly other factors determine the ultimate phenotype; however, the findings provide insights into the variable disease patterns in lupus nephritis.
authors: Michael P
authors: MP
authors: Madaio
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D004247:DNA / Q000276:immunology*; D050533:Glomerular Basement Membrane / Q000276:immunology*; D008181:Lupus Nephritis / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D004247:DNA