title: Noninvasive prediction of intra-amniotic infection and/or inflammation in women with preterm labor: various cytokines in cervicovaginal fluid.
abstract: OBJECTIVE
  To determine the value of cervicovaginal interleukin (IL)-1β, IL-6, and IL-8 in predicting intra-amniotic infection and/or inflammation (IAI) in women with preterm labor.
  
  
  METHODS
  Cervicovaginal fluid samples were collected for IL-1β, IL-6, and IL-8 measurements immediately before amniocentesis in 85 consecutive women with preterm labor. The IAI was defined as a positive amniotic fluid (AF) culture and/or an elevated AF IL-6 level (>2.6 ng/mL).
  
  
  RESULTS
  Receiver-operating characteristic curves demonstrated that cervicovaginal IL-6 and IL-8, but not IL-1β, predicted IAI. Cervicovaginal IL-6 had a significantly higher area under the curve (AUC) than cervicovaginal IL-8 (P = .009). However, the AUCs for the cervicovaginal IL-6 and AF white blood cell (WBC) were not significantly different.
  
  
  CONCLUSIONS
  Among measured cytokines, cervicovaginal IL-6 is the best marker to noninvasively identify IAI in women with preterm labor. Overall, this noninvasive parameter performed as well as AF WBC count for predicting IAI.
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Jeong Woo
authors: JW
authors: Park
authors: Kyo Hoon
authors: KH
authors: Park
authors: Sung Youn
authors: SY
authors: Lee
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000379:methods; D000653:Amniotic Fluid / Q000378:metabolism / Q000382:microbiology*; D002584:Cervix Uteri / Q000378:metabolism / Q000382:microbiology*; D015331:Cohort Studies; D016207:Cytokines / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology; D007752:Obstetric Labor, Premature / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology*; D011446:Prospective Studies; D014621:Vagina / Q000378:metabolism / Q000382:microbiology*
chemical_list: D016207:Cytokines