title: Lack of effect of sleep apnea on oxidative stress in obstructive sleep apnea syndrome (OSAS) patients.
abstract: OBJECTIVE
  The aim of this study was to evaluate markers of systemic oxidative stress and antioxidant capacity in subjects with and without OSAS in order to investigate the most important factors that determine the oxidant-antioxidant status.
  
  
  METHODS
  A total of 66 subjects referred to our Sleep laboratory were examined by full polysomnography. Oxidative stress and antioxidant activity were assessed by measurement of the derivatives of reactive oxygen metabolites (d-ROMs) and the biological antioxidant capacity (BAP) in blood samples taken in the morning after the sleep study. Known risk factors for oxidative stress, such as age, sex, obesity, smoking, hypelipidemia, and hypertension, were investigated as possible confounding factors.
  
  
  RESULTS
  42 patients with OSAS (Apnea-Hypopnea index >15 events/hour) were compared with 24 controls (AHI<5). The levels of d-ROMS were significantly higher (p = 0.005) in the control group but the levels of antioxidant capacity were significantly lower (p = 0.004) in OSAS patients. The most important factors predicting the variance of oxidative stress were obesity, smoking habit, and sex. Parameters of sleep apnea severity were not associated with oxidative stress. Minimal oxygen desaturation and smoking habit were the most important predicting factors of BAP levels.
  
  
  CONCLUSIONS
  Obesity, smoking, and sex are the most important determinants of oxidative stress in OSAS subjects. Sleep apnea might enhance oxidative stress by the reduction of antioxidant capacity of blood due to nocturnal hypoxia.
authors: 1st Department of Respiratory Medicine, Medical School, University of Athens, Sotiria Hospital for Chest Diseases, Athens, Greece.
authors: M
authors: M
authors: Simiakakis
authors: F
authors: F
authors: Kapsimalis
authors: E
authors: E
authors: Chaligiannis
authors: S
authors: S
authors: Loukides
authors: N
authors: N
authors: Sitaras
authors: M
authors: M
authors: Alchanatis
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017286:Polysomnography; D011379:Prognosis; D012307:Risk Factors; D012737:Sex Factors; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D015415:Biomarkers