title: Methylation muscles into transcription factor silencing.
abstract: The transcription factor MyoD is a master regulator of skeletal muscle differentiation. The finding that G9a, an enzyme principally involved in histone H3 lysine 9 di-methylation (H3K9me2), methylates MyoD, identifies previously unappreciated mechanisms by which chromatin modifiers regulate the transcriptional activity of non-histone substrates to control cellular differentiation programs.
authors: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors: Narendra
authors: N
authors: Bharathy
authors: Reshma
authors: R
authors: Taneja
mesh_terms: D000818:Animals; D057890:Epigenomics; D006801:Humans; D008745:Methylation; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000254:growth & development*; D017570:MyoD Protein / Q000737:chemistry / Q000502:physiology*
chemical_list: D017570:MyoD Protein