title: Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS.
abstract: Previous analyses of the naphthomycin biosynthetic gene cluster and a comparison with known naphthomycin-type products from Streptomyces sp. CS have suggested that new products can be found from this strain. In this study, screening by LC-MS of Streptomyces sp. CS products formed under different culture conditions revealed several unknown peaks in the product spectra of extracts derived from oatmeal medium cultures. Three new naphthomycins, naphthomycins L (1), M (2), and N (3), and the known naphthomycins A (4), E (5), and D (6) were obtained. The structures were elucidated using spectroscopic data from 1D and 2D NMR and HRESIMS experiments.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China,  Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors: Yin-He
authors: YH
authors: Yang
authors: Xiao-Li
authors: XL
authors: Fu
authors: Liang-Qun
authors: LQ
authors: Li
authors: Ying
authors: Y
authors: Zeng
authors: Cheng-Yun
authors: CY
authors: Li
authors: Yi-Neng
authors: YN
authors: He
authors: Pei-Ji
authors: PJ
authors: Zhao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D005810:Multigene Family; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009285:Naphthoquinones; C575783:naphthomycin L; C575784:naphthomycin M; C575782:naphthomycin N