title: Performance of MAX test and degree of dominance index in predicting the mode of inheritance.
abstract: We evaluate power performance to detect the correct mode of inheritance in gene-disease associations of two different approaches: the MAX test and the degree of dominance index or h-index. The MAX test is a special case of the conditional independence tests that simultaneously test for association and select the most likely genetic model based on a three-dimensional normal distribution. The h-index is based on the philosophy of using orthogonal contrasts to infer the mode of inheritance quantitatively. A population genetic model is developed where the real mode of inheritance is known a priori and power performance can be accurately determined. The simulations showed that none of the two approaches generally outperforms the other, nor each of them provides a panacea to estimate efficiently the mode of inheritance in all parameter space. However, the simultaneous application of both approaches can provide insights in determining the underlying mode of inheritance.
authors: Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Str, Larissa 41110, Greece.
authors: Elias
authors: E
authors: Zintzaras
authors: Mauro
authors: M
authors: Santos
mesh_terms: D005799:Genes, Dominant / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D040582:Inheritance Patterns; D008957:Models, Genetic; D015233:Models, Statistical