title: Lanreotide autogel-induced acute pancreatitis in a patient with acromegaly.
abstract: Somatostatin and somatostatin analogues are considered very useful for the treatment of hormone producing tumors and acute variceal bleeding. They have also been proposed for the treatment of acute pancreatitis and for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis although clinical trials have failed to show any efficacy. The authors report the case of a 45-year-old man, recently diagnosed of acromegaly, which developed an acute pancreatitis shortly after his first injection of lanreotide autogel. The patient developed a severe dilatation of his hypocontractile gallbladder with distension of the intra and extrahepatic biliary ducts, the choledochus and the main pancreatic duct, without lithiasis or other abnormalities at the papilla, which resolved spontaneously in a month. We consider that lanreotide most likely induced a functional spasm of the Sphincter of Oddi, with impairment of the biliary-pancreatic outflow, leading to an acute pancreatitis, and review the literature concerning this drug related pancreatitis.
authors: Department of Internal Medicine, Hospital Perpetuo Socorro, Badajoz, Spain. j.tiago.silva@hotmail.com
authors: José Tiago
authors: JT
authors: Sequeira Lopes da Silva
authors: Olga
authors: O
authors: González Casas
authors: Verónica
authors: V
authors: Bejarano Moguel
authors: Maria
authors: M
authors: Lobo Pascua
authors: Antonio
authors: A
authors: López-Santamaría Redondo
authors: Remigio
authors: R
authors: Cordero Torres
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced*; D010456:Peptides, Cyclic / Q000009:adverse effects*; D013004:Somatostatin / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin