title: A novel preparation method for 5-aminosalicylic acid loaded Eudragit S100 nanoparticles.
abstract: In this study, solution enhanced dispersion by supercritical fluids (SEDS) technique was applied for the preparation of 5-aminosalicylic acid (5-ASA) loaded Eudragit S100 (EU S100) nanoparticles. The effects of various process variables including pressure, temperature, 5-ASA concentration and solution flow rate on morphology, particle size, 5-ASA loading and entrapment efficiency of nanoparticles were investigated. Under the appropriate conditions, drug-loaded nanoparticles exhibited a spherical shape and small particle size with narrow particle size distribution. In addition, the nanoparticles prepared were characterized by X-ray diffraction, Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses. The results showed that 5-ASA was imbedded into EU S100 in an amorphous state after SEDS processing and the SEDS process did not induce degradation of 5-ASA.
authors: Department of Clinical Pharmacology, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China.|College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors: Daode
authors: D
authors: Hu
authors: Department of Clinical Pharmacology, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China.
authors: Liang
authors: L
authors: Liu
authors: Department of Clinical Pharmacology, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200080, China.
authors: Wenjuan
authors: W
authors: Chen
authors: College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors: Sining
authors: S
authors: Li
authors: College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors: Yaping
authors: Y
authors: Zhao
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D019804:Mesalamine / Q000138:chemical synthesis*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; C050528:Eudragit RS; D019804:Mesalamine