title: [Tadalafil improves total testosterone, IIEF score and SEP in old and middle-aged males with late-onset hypogonadism].
abstract: OBJECTIVE
  To observe the clinical effect of tadalafil combined with testosterone undecanoate on late-onset hypogonadism (LOH) in old and middle-aged males.
  
  
  METHODS
  A total of 125 old and middle-aged (40 to 60 years) males with LOH were randomly assigned to a treatment group (n = 65) and a control group (n = 60) to be treated with tadalafil + testosterone undecanoate and testosterone undecanoate alone, respectively. We compared the levels of total testosterone (T), IIEF scores and the patients' sexual encounter profile (SEP) diaries before and 4 weeks after medication.
  
  
  RESULTS
  The T level, IIEF score and SEP score were significantly improved in both groups after medication as compared with the baseline (P < 0.05), and even more so in the treatment than in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Tadalafil combined with testosterone undecanoate, superior to testosterone undecanoate alone, can improve the T level, IIEF score and SEP score in old and middle-aged males with LOH and increase their sexual satisfaction and self-confidence.
authors: Department of Urology, The First Hospital Affiliated to Guangdong Pharmaceutical College, Guangzhou, Guangdong. 18820030620@139.com
authors: Xi-Kun
authors: XK
authors: Wang
authors: Li
authors: L
authors: Luo
authors: Sen
authors: S
authors: Wang
authors: Jun
authors: J
authors: Li
authors: Wen-Xiong
authors: WX
authors: Li
mesh_terms: D002243:Carbolines / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D012725:Sexual Behavior; D000068581:Tadalafil; D013739:Testosterone / Q000031:analogs & derivatives / Q000032:analysis* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D013739:Testosterone; D000068581:Tadalafil; C010792:testosterone undecanoate