title: Correlation of indocyanine green angiography and optical coherence tomography findings after intravitreal ranibizumab for polypoidal choroidal vasculopathy.
abstract: OBJECTIVE
  To evaluate findings in eyes with polypoidal choroidal vasculopathy on indocyanine green angiography (ICGA) and optical coherence tomography (OCT) over 3 months after ranibizumab treatment.
  
  
  METHODS
  Fifty-one eyes from 51 patients with treatment-naive polypoidal choroidal vasculopathy received intravitreal ranibizumab injections. We evaluated changes in polypoidal lesions on ICGA and OCT and their correlation over 3 months. Ranibizumab was injected again based on the presence of residual fluid on OCT.
  
  
  RESULTS
  Indocyanine green angiography detected 75 polypoidal lesions. All corresponding OCT lesions showed baseline protrusion of the retinal pigment epithelium. At 3 months, 26 lesions (35%) resolved on ICGA: retinal pigment epithelium protrusion on OCT resolved in 10 lesions (38%), 10 lesions (38%) decreased in height, and 6 lesions (24%) remained unchanged. Forty-nine lesions persisted on ICGA, retinal pigment epithelium protrusion resolved in 2 lesions (4%), decreased in 4 lesions (8%), were stable in 36 lesions (73%), and increased in 7 lesions (15%). Three lesions newly developed. Six eyes (12%) had resolved lesions, and 33 eyes (67%) had persistent lesions on ICGA and OCT. Residual exudative changes were associated with persistent lesions on OCT.
  
  
  CONCLUSIONS
  Indocyanine green angiography and OCT baseline findings of polypoidal lesions in polypoidal choroidal vasculopathy were well correlated; however, a discrepancy was seen during treatment. Polypoidal lesions persisted more often on OCT, although ICGA and OCT showed the efficacy of ranibizumab for some polypoidal lesions.
authors: Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Chikako
authors: C
authors: Ueno
authors: Fumi
authors: F
authors: Gomi
authors: Miki
authors: M
authors: Sawa
authors: Kohji
authors: K
authors: Nishida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D002829:Choroid / Q000098:blood supply; D015862:Choroid Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000188:drug therapy; D011127:Polyps / Q000175:diagnosis* / Q000188:drug therapy; D000069579:Ranibizumab; D013223:Statistics as Topic; D041623:Tomography, Optical Coherence
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D004396:Coloring Agents; D007208:Indocyanine Green; D000069579:Ranibizumab