title: Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients.
abstract: Immunophenotype is critical for diagnosing common B-cell acute lymphoblastic leukemia (common ALL) and detecting minimal residual disease. We developed a protocol to explore the immunophenotypic profiles of common ALL based on the expression levels of the antigens associated with B lymphoid development, including IL-7Rα (CD127), cytoplasmic CD79a (cCD79a), CD19, VpreB (CD179a), and sIgM, which are successive and essential for progression of B cells along their developmental pathway. Analysis of the immunophenotypes of 48 common ALL cases showed that the immunophenotypic patterns were highly heterogeneous, with the leukemic cell population differing from case to case. Through the comprehensive analysis of immunophenotypic patterns, the profiles of patient-specific composite leukemia cell populations could provide detailed information helpful for the diagnosis, therapeutic monitoring, and individualized therapies for common ALL.
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
authors: Jian-Hua
authors: JH
authors: Yu
authors: Jing-Tao
authors: JT
authors: Dong
authors: Yong-Qian
authors: YQ
authors: Jia
authors: Neng-Gang
authors: NG
authors: Jiang
authors: Ting-Ting
authors: TT
authors: Zeng
authors: Hong
authors: H
authors: Xu
authors: Xian-Ming
authors: XM
authors: Mo
authors: Wen-Tong
authors: WT
authors: Meng
mesh_terms: D000328:Adult; D018941:Antigens, CD19 / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D051925:CD79 Antigens / Q000378:metabolism; D005260:Female; D006801:Humans; D054444:Immunoglobulin Light Chains, Surrogate / Q000378:metabolism; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000473:pathology; D020395:Receptors, Interleukin-7 / Q000378:metabolism
chemical_list: D018941:Antigens, CD19; D051925:CD79 Antigens; C497881:CD79A protein, human; D054444:Immunoglobulin Light Chains, Surrogate; D020395:Receptors, Interleukin-7; C515639:VPREB1 protein, human; C415350:interleukin-7 receptor, alpha chain