title: Lathyrane diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production.
abstract: A new lathyrane diterpene (1), an unreported spectroscopic data lathyrane diterpenene (2), and two known analaogues (3 and 4) have been isolated from Euphorbia prolifera. Their structures were elucidated as (12E,2S,3S,4R,5R,6S,9S,11S,15R)-3-butyryloxy-5,15-diacetoxy-6,17-epoxylathyra- 12-en-14-one (1), (12E,2S,3S,4R,5R,6S,9S,11S,15R)-3-propionyloxy-5,15-diacetoxy-6,17- epoxylathyra-12-en-14-one (2), (12E,2S,3S,4R,5R,6S,9S,11S,15R)-3-benzoyloxy-5,15-diacetoxy -6,17-epoxylathyra-12-en-14-one (3), and 15-O-acetyl-17-hydroxyjolkinol (4) by spectroscopic methods (IR, ESIMS, HR-ESIMS, NMR, and X-ray crystallography). The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and compounds 1, 3 and 4 showed inhibitory effects.
authors: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors: Jing
authors: J
authors: Xu
authors: Da-qing
authors: DQ
authors: Jin
authors: Haibin
authors: H
authors: Song
authors: Yuanqiang
authors: Y
authors: Guo
authors: Yisha
authors: Y
authors: He
mesh_terms: D000818:Animals; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D028481:Euphorbia / Q000737:chemistry*; D008070:Lipopolysaccharides; D051379:Mice; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C577179:(12E,2S,3S,4R,5R,6S,9S,11S,15R)-3-butyryloxy-5,15-diacetoxy-6,17-epoxylathyra-12-en-14-one; C577180:(12E,2S,3S,4R,5R,6S,9S,11S,15R)-3-propionyloxy-5,15-diacetoxy-6,17-epoxylathyra-12-en-14-one; D004224:Diterpenes; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide