title: Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds.
abstract: A one-pot tandem process involving an Overman rearrangement, ring closing enyne metathesis and a hydrogen bonding directed Diels-Alder reaction has been developed for the efficient diastereoselective synthesis of functionalised amino substituted tetralin and indene ring systems.
authors: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
authors: Mark W
authors: MW
authors: Grafton
authors: Louis J
authors: LJ
authors: Farrugia
authors: Hans Martin
authors: HM
authors: Senn
authors: Andrew
authors: A
authors: Sutherland
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D006860:Hydrogen Bonding; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D007192:Indenes; D013764:Tetrahydronaphthalenes; C093581:indene; C095210:tetralin