title: Selective inhibition of inducible nitric oxide synthase by derivatives of acetamidine.
abstract: A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.
authors: Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Chieti, Italy.
authors: Cristina
authors: C
authors: Maccallini
authors: Antonia
authors: A
authors: Patruno
authors: Alessandra
authors: A
authors: Ammazzalorso
authors: Barbara
authors: B
authors: De Filippis
authors: Marialuigia
authors: M
authors: Fantacuzzi
authors: Sara
authors: S
authors: Franceschelli
authors: Letizia
authors: L
authors: Giampietro
authors: Simona
authors: S
authors: Masella
authors: Maria Luisa
authors: ML
authors: Tricca
authors: Rosa
authors: R
authors: Amoroso
mesh_terms: D000578:Amidines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008024:Ligands; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D061987:Sf9 Cells; D018411:Spodoptera; D013379:Substrate Specificity
chemical_list: D000578:Amidines; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D008024:Ligands; D052247:Nitric Oxide Synthase Type II; C023731:acetamidine