title: Liver cirrhosis but not alcohol abuse is associated with impaired outcome in trauma patients - a retrospective, multicentre study.
abstract: BACKGROUND
  Liver cirrhosis has been shown to be associated with impaired outcome in patients who underwent elective surgery. We therefore investigated the impact of alcohol abuse and subsequent liver cirrhosis on outcome in multiple trauma patients.
  
  
  METHODS
  Using the multi-centre population-based Trauma Registry of the German Society for Trauma Surgery, we retrospectively compared outcome in patients (ISS ≥ 9, ≥ 18) with pre-existing alcohol abuse and liver cirrhosis with healthy trauma victims in univariate and matched-pair analysis. Means were compared using Student's t-test and analysis of variance (ANOVA) and categorical variables using χ(2) (p<0.05=significant).
  
  
  RESULTS
  Overall 13,527 patients met the inclusion criteria and were, thus, analyzed. 713 (5.3%) patients had a documented alcohol abuse and 91 (0.7%) suffered from liver cirrhosis. Patients abusing alcohol and suffering from cirrhosis differed from controls regarding injury pattern, age and outcome. More specific, liver cirrhotic patients showed significantly higher in-hospital mortality than predicted (35% vs. predicted 19%) and increased single- and multi-organ failure rates. While alcohol abuse increased organ failure rates as well this did not affect in-hospital mortality.
  
  
  CONCLUSIONS
  Patients suffering from liver cirrhosis presented impaired outcome after multiple injuries. Pre-existing condition such as cirrhosis should be implemented in trauma scores to assess the individual mortality risk profile.
authors: Department of Trauma, Hand and Reconstructive Surgery, Hospital of the Johann Wolfgang, Goethe-University, Frankfurt, Germany. christoph.nau@kgu.de
authors: Christoph
authors: C
authors: Nau
authors: Sebastian
authors: S
authors: Wutzler
authors: Hagen
authors: H
authors: Dörr
authors: Mark
authors: M
authors: Lehnert
authors: Rolf
authors: R
authors: Lefering
authors: Helmut
authors: H
authors: Laurer
authors: Hendrik
authors: H
authors: Wyen
authors: Ingo
authors: I
authors: Marzi
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000401:mortality* / Q000628:therapy; D000704:Analysis of Variance; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015601:Injury Severity Score; D008103:Liver Cirrhosis / Q000150:complications / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D009104:Multiple Trauma; D016017:Odds Ratio; D010976:Platelet Count; D011517:Prothrombin Time; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014193:Trauma Centers; D014947:Wounds and Injuries / Q000150:complications / Q000401:mortality* / Q000628:therapy