title: CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection.
abstract: We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
authors: Department of Immunology; Memorial Sloan-Kettering Cancer Center; Howard Hughes Medical Institute; New York, NY USA.
authors: Rebecca
authors: R
authors: Waitz
authors: Marcella
authors: M
authors: Fassò
authors: James P
authors: JP
authors: Allison