title: Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.
abstract: Canine distemper virus (CDV) uses signaling lymphocyte activation molecule (SLAM), expressed on immune cells, as a receptor. However, epithelial and neural cells are also affected by CDV in vivo. Wild-type CDV strains showed efficient replication with syncytia in Vero cells expressing dog nectin4, and the infection was blocked by an anti-nectin4 antibody. In dogs with distemper, CDV antigen was preferentially detected in nectin4-positive neurons and epithelial cells, suggesting that nectin4 is an epithelial cell receptor for CDV and also involved in its neurovirulence.
authors: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors: Watanyoo
authors: W
authors: Pratakpiriya
authors: Fumio
authors: F
authors: Seki
authors: Noriyuki
authors: N
authors: Otsuki
authors: Kouji
authors: K
authors: Sakai
authors: Hideo
authors: H
authors: Fukuhara
authors: Hiromu
authors: H
authors: Katamoto
authors: Takuya
authors: T
authors: Hirai
authors: Katsumi
authors: K
authors: Maenaka
authors: Somporn
authors: S
authors: Techangamsuwan
authors: Nguyen Thi
authors: NT
authors: Lan
authors: Makoto
authors: M
authors: Takeda
authors: Ryoji
authors: R
authors: Yamaguchi
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002522:Chlorocebus aethiops; D004216:Distemper / Q000821:virology; D004217:Distemper Virus, Canine / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology*; D004285:Dogs; D054884:Host-Pathogen Interactions / Q000502:physiology; D000075983:Nectins; D009474:Neurons / Q000821:virology; D011991:Receptors, Virus / Q000502:physiology*; D014709:Vero Cells; D014774:Virulence / Q000502:physiology
chemical_list: D000956:Antigens, Viral; D015815:Cell Adhesion Molecules; D000075983:Nectins; D011991:Receptors, Virus