title: An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae.
abstract: We described herein a concise synthesis of 3',4'-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3',4'-diaminoflavone 11 and 5,7-dimethoxy-3',4'-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with -102.3% of ROS-scavenging rate.
authors: Department of Chemistry, Tamkang University, Tamsui Dist., 25137 New Taipei City, Taiwan. tlshih@mail.tku.edu.tw
authors: Tzenge-Lien
authors: TL
authors: Shih
authors: Chih-Ang
authors: CA
authors: Hsiao
authors: Zi-Yu
authors: ZY
authors: Lin
authors: Yau-Hung
authors: YH
authors: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D019610:Cytoprotection / Q000187:drug effects / Q000528:radiation effects; D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D007814:Larva / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D047309:Flavones; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species