title: [The effect of SSH&H on the lifespan and spontaneous cancer development in transgenic mice with HER-2/neu mutation].
abstract: 10 months old mice receiving SSH&H with daily food increased the lifespan in comparison to the control group. The maximal lifespan was increased by 1,6 months. For the long-living 10% group the mean lifespan increased by 8,7% compared to the control group (p<0,05). The mammary gland neoplasia rate was the same in both groups. The mean latent tumor development period duration, number and size of the tumors were also similar. There was a tendency to lower lung metastases rate in the experimental group. The cumulative neoplastic frequency curve for the experimental group was shifted to the right in comparison to the control group curve giving evidence to the inhibitory effect of SSH&H on the neoplastic rate in transgenic mice with HER-2/neu mutation.
authors: M L
authors: ML
authors: Tyndyk
authors: I G
authors: IG
authors: Popovich
authors: I V
authors: IV
authors: Anikin
authors: P A
authors: PA
authors: Egormin
authors: M N
authors: MN
authors: Iurova
authors: M A
authors: MA
authors: Zabezhinskiĭ
authors: V N
authors: VN
authors: Anisimov
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D005260:Female; D005503:Food Additives / Q000494:pharmacology; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*
chemical_list: D016588:Anticarcinogenic Agents; D005503:Food Additives; D018719:Erb-b2 Receptor Tyrosine Kinases; C524056:Erbb2 protein, mouse