title: Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.
abstract: Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.
authors: Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany.
authors: Inke
authors: I
authors: Lühr
authors: Andreas
authors: A
authors: Friedl
authors: Thorsten
authors: T
authors: Overath
authors: Andreas
authors: A
authors: Tholey
authors: Thomas
authors: T
authors: Kunze
authors: Felix
authors: F
authors: Hilpert
authors: Susanne
authors: S
authors: Sebens
authors: Norbert
authors: N
authors: Arnold
authors: Frank
authors: F
authors: Rösel
authors: Hans-Heinrich
authors: HH
authors: Oberg
authors: Nicolai
authors: N
authors: Maass
authors: Christoph
authors: C
authors: Mundhenke
authors: Walter
authors: W
authors: Jonat
authors: Maret
authors: M
authors: Bauer
mesh_terms: D001940:Breast / Q000166:cytology* / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D048430:Cell Shape; D002478:Cells, Cultured / Q000502:physiology; D018920:Coculture Techniques; D003187:Compliance; D004847:Epithelial Cells / Q000166:cytology* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis; D019899:Paracrine Communication; D010641:Phenotype; D013314:Stress, Mechanical; D017154:Stromal Cells / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000648:ultrastructure; D059016:Tumor Microenvironment / Q000502:physiology*