title: Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.
abstract: Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts. The fibrous septa are generally thin and there is no discernible expansile nodule. Microscopically, the cyst walls are lined with tumor cells with clear to occasionally slightly eosinophilic cytoplasm. The Fuhrman nuclear grade is generally low and usually corresponds to grade 1. The deletion of chromosome 3p was identified in most tumors using FISH analysis and VHL gene mutation was identified in 25% of MCRCC. As MCRCC generally exhibits a low stage of TNM classification, the great majority of these tumors have a favorable clinical course. To date, there are no reports of metastasis, vascular invasion or sarcomatoid change in MCRCC. Accordingly, nephron sparing surgery is first recommended as a therapeutic strategy.
authors: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan. kurochankochi@yahoo.co.jp
authors: Naoto
authors: N
authors: Kuroda
authors: Chisato
authors: C
authors: Ohe
authors: Shuji
authors: S
authors: Mikami
authors: Keiji
authors: K
authors: Inoue
authors: Yoji
authors: Y
authors: Nagashima
authors: Ronald J
authors: RJ
authors: Cohen
authors: Chin-Chen
authors: CC
authors: Pan
authors: Michal
authors: M
authors: Michal
authors: Ondrej
authors: O
authors: Hes
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D033162:Incidental Findings; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D052177:Kidney Diseases, Cystic / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D009154:Mutation; D009367:Neoplasm Staging; D035583:Rare Diseases; D014463:Ultrasonography; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human