title: Association of epidermal growth factor receptor gene polymorphisms with advanced endometriosis in a Korean population.
abstract: OBJECTIVE
  To determine if specific single nucleotide polymorphisms (SNPs) in the Epidermal Growth Factor Receptor (EGFR) gene were meaningful markers for the risk of advanced stage endometriosis in a Korean population.
  
  
  METHODS
  Case-control study in a collective of 299 women with endometriosis and 285 controls. Three polymorphisms (151904 A>T [T628T] on exon 16 [rs 17337023], 162093 G>A [Q787Q] on exon 20 [rs 10251977], and 181946 C>T [D994D] on exon 25 [rs 2293347]) were assessed by a Minor Groove Binder (MGB) primer/probe Taqman assay. In-silico haplotypes were deduced using the Haploview (version 3.32) software package.
  
  
  RESULTS
  There were no statistically significant differences in the genotype or haplotype frequencies of the three EGFR polymorphisms between subjects with endometriosis versus the control group. Even when the endometriosis cases were subdivided into stage III and IV based on the ASRM criteria, no statistically significant differences in genotype distribution or haplotype frequencies were observed between the three groups.
  
  
  CONCLUSIONS
  Our results suggest that the 151904 A>T, 162093 G>A, and 181946 C>T polymorphisms in the EGFR gene are not associated with advanced stage endometriosis in a Korean population. Our results are in agreement with the results reported by Inagaki et al.
authors: Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Republic of Korea.
authors: Gyoung Hoon
authors: GH
authors: Lee
authors: Young Min
authors: YM
authors: Choi
authors: Jong Mee
authors: JM
authors: Kim
authors: Jae Jun
authors: JJ
authors: Shin
authors: Jung Gu
authors: JG
authors: Kim
authors: Shin Yong
authors: SY
authors: Moon
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D019295:Computational Biology; D004715:Endometriosis / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005091:Exons; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006785:Hospitals, University; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors