title: Effects of polyunsaturated fatty acids (PUFAs) in the treatment of experimental chronic renal failure.
abstract: OBJECTIVE
  A diet with polyunsaturated fatty acid (PUFA) supplementation has been reported to reduce renal and cardiac diseases. This study sought to elucidate whether PUFAs derived from plant or marine oils could have beneficial effects on the progression of experimental chronic renal failure (CRF).
  
  
  METHODS
  Experimental CRF was achieved by a 5/6 nephrectomy model. Male Wistar rats were divided into groups and given daily supplements of fish oil (group FO), flaxseed oil (group FXO), or soybean oil (control-group SO) for 30 days. Serum creatinine (sCr), 24-h proteinuria, total cholesterol, triglycerides, and creatinine clearance (CLcr) were measured at day 0 and 30 days after surgery when the rats were euthanized for histological analysis of the remnant kidney.
  
  
  RESULTS
  After 30 days, we observed lower levels of sCr in the groups supplemented with PUFA when compared with the control group (FO: 0.92 ± 0.13; FXO: 1.06 ± 0.28; SO: 1.32 ± 0.47 mg/dL) and significantly slower variations of sCr (ΔsCr) in the groups treated with PUFAs (FO = 0.35 ± 0.16; FXO = 0.47 ± 0.31; OS = 0.72 ± 0.43; mg/dL, P = 0.041). Similarly, the CLcr of both of the groups that received PUFAs was significantly slower than the rats in the control group (FO: 0.45 ± 0.15; FXO: 0.60 ± 0.09; SO: 0.28 ± 0.06 mL/min/day; P = 0.01). The rats that received PUFA supplements also presented significantly less histological lesions compared with the control group.
  
  
  CONCLUSIONS
  These results suggest a beneficial effect of dietary supplementation with flaxseed or fish oil in rats with CRF.
authors: Laboratory of Immunology and Experimental Transplantation-LITEX, FAMERP/FUNFARME, Hospital de Base, Av. Brigadeiro Faria Lima 5416-15090-000, São Jose do Rio Preto, SP, Brazil.
authors: Marcelo Bandeira
authors: MB
authors: Fernandes
authors: Heloisa Cristina
authors: HC
authors: Caldas
authors: Leila Rodrigues
authors: LR
authors: Martins
authors: Cristiane Camargo
authors: CC
authors: Ferreira
authors: Maria Alice Sperto Ferreira
authors: MA
authors: Baptista
authors: Ida Maria Maximina
authors: IM
authors: Fernandes
authors: Mario
authors: M
authors: Abbud-Filho
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000652:urine; D019587:Dietary Supplements; D018450:Disease Progression; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005395:Fish Oils / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008043:Linseed Oil / Q000627:therapeutic use; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D014280:Triglycerides; D013024:Soybean Oil; D008043:Linseed Oil; D002784:Cholesterol; D003404:Creatinine