title: [Observation on therapeutic effect of acupuncture of five Shu-points of the liver meridian combined with bloodletting for depression patients and concomitant changes of blood rheology].
abstract: OBJECTIVE
  To observe the clinical efficacy of acupuncture of five Shu-points of the Liver Meridian plus bloodletting for depression patients and its effect on hemorheology.
  
  
  METHODS
  Thirty depression outpatients were randomly and equally divided into medication and acupuncture + bloodletting groups. Patients of the medication group were treated with Fluoxetine (20 mg/d, PO. in the morning) and those of the acupuncture + bloodletting group treated by acupuncture of Xingjian (LR 2), Taichong (LR 3), Zhongfeng (LR 4) and Ququan (LR 5) first, followed by pricking Dadun (LR 1) to let a little bit of blood out. The treatment was given once every other day, two months altogether. The therapeutic effect was assessed by using Hamilton Depression Rating Scale (HAMD) and the Clinical Global Impression Scale for Severity of Illness (CGI-SI) before and 1, 2, 4, 6, and 8 weeks after the treatment, respectively. Changes of hemorheology were detected by using a blood rheology detector.
  
  
  RESULTS
  Of the 15 outpatients in both medication and acupuncture + bloodletting groups, 6 (40.00%) and 6 (40.00%) were cured basically, 5 (33.34%) and 4 (26.67%) experienced marked improvement, 2 (13.33%) and 3 (20.00%) were improved, and 2 (13.33%) and 2 (13.33%) invalid, respectively. No significant difference was found between the two groups in the therapeutic effect (P > 0.05). On the 6th and 8th weeks of the treatment, the CGI-SI score of the acupuncture + bloodletting group was significantly lower than that of the medication group (P < 0.05), suggesting a better therapeutic effect of the acupuncture + bloodletting group. The low and high shear viscosity of whole blood, erythrocyte aggregation index and rigidity index, and fibrinogen levels of the two groups were decreased significantly after the treatment (P < 0.05). No significant difference was found between the two groups in the changes of hemorheology indexes following the treatment (P > 0.05).
  
  
  CONCLUSIONS
  Acupuncture of the five Shu-points of the Liver Meridian combined with bloodletting is effective in relieving depression symptoms and improving blood rheology in depression patients.
authors: College of Chinese Medicine, Chongqing Medical University, Chongqing 400016, China.
authors: Hong-Wu
authors: HW
authors: Xie
authors: Chun-Yan
authors: CY
authors: Bai
authors: Yang
authors: Y
authors: Yi
authors: Fang-Ming
authors: FM
authors: Xu
authors: Yun-E
authors: YE
authors: Song
authors: La-Mei
authors: LM
authors: Li
authors: Xi
authors: X
authors: Tang
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000328:Adult; D000368:Aged; D001815:Bloodletting; D003131:Combined Modality Therapy; D003863:Depression / Q000097:blood* / Q000628:therapy*; D005260:Female; D018056:Hemorheology; D006801:Humans; D016740:Meridians; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult