title: Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells.
abstract: Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effective in reducing cancer cell viability. The combination of 3-HF and imatinib mesylate resulted in significant apoptotic cell death in imatinib mesylate-resistant leukemia cells. Combined treatment resulted in apparent activation of caspases and decrease of the oncoprotein phosphor-Bcr/Abl in leukemia cells. Our results suggest that this combined treatment is beneficial in imatinib mesylate-resistant chronic myelogenous leukemia.
authors: Department of Animal Biotechnology and Animal Resources Research Center, Konkuk University, Seoul, Republic of Korea.
authors: Jung-Hyun
authors: JH
authors: Kim
authors: Minjung
authors: M
authors: Song
authors: Geun-Ho
authors: GH
authors: Kang
authors: Eung-Ryoung
authors: ER
authors: Lee
authors: Hye-Yeon
authors: HY
authors: Choi
authors: Chung
authors: C
authors: Lee
authors: Jin-Hoi
authors: JH
authors: Kim
authors: Youngsoo
authors: Y
authors: Kim
authors: Bon-Nyeo
authors: BN
authors: Koo
authors: Ssang-Goo
authors: SG
authors: Cho
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D001549:Benzamides; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004285:Dogs; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D005419:Flavonoids / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D000068877:Imatinib Mesylate; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology*; D010879:Piperazines / Q000008:administration & dosage* / Q000494:pharmacology; D011743:Pyrimidines / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D001549:Benzamides; D005419:Flavonoids; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; C041477:3-hydroxyflavone