title: The myeloid cytokine network in AIDS pathogenesis.
abstract: The complex pathogenesis of HIV and SIV infections involves the activation, dysfunction, and increased turnover of numerous immune cell subsets. Myeloid cells, including monocytes, macrophages, and myeloid dendritic cells (mDCs), are a particularly relevant cell type capable of providing targets for virus infection as well as a source of immunomodulatory cytokines and chemokines. Here, we review recent literature about the interplay between HIV/SIV and myeloid cells, including viral infection, type I interferon signaling, and the contribution of myeloid cells to HIV-associated immune activation. Understanding the cytokine and chemokine networks in which monocytes, macrophages, and mDCs participate during HIV infection may yield new insights into the pathogenesis of the disease.
authors: Yerkes National Primate Research Center, Emory University, & Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, United States. kiran.d.mir@emory.edu
authors: Kiran D
authors: KD
authors: Mir
authors: Maud
authors: M
authors: Mavigner
authors: Guido
authors: G
authors: Silvestri
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000821:virology; D018448:Models, Immunological; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology
chemical_list: D016207:Cytokines