title: 6-Trifluoromethylpyridoxine: novel (19)F NMR pH indicator for in vivo detection.
abstract: pH plays an important role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy, and accurate noninvasive assessment of tumor pH promises to provide insight into developmental processes and prognostic information. In this paper, we report the design, synthesis, and characterization of two novel pH indicators 6-trifluoromethylpyridoxine 8 and α(4),α(5)-di-O-[3'-O-(β-d-glucopyranosyl)propyl]-6-trifluoromethylpyridoxine 17 and demonstrate 8 as an extracellular (19)F NMR pH probe to assess pH(e) of various tumors in vivo.
authors: Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center at Dallas , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9058, United States. Jian-Xin.Yu@UTSouthwestern.edu
authors: Jian-Xin
authors: JX
authors: Yu
authors: Weina
authors: W
authors: Cui
authors: Vincent A
authors: VA
authors: Bourke
authors: Ralph P
authors: RP
authors: Mason
mesh_terms: D000818:Animals; D005110:Extracellular Space / Q000737:chemistry; D005260:Female; D005461:Fluorine; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009206:Myocardium / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000737:chemistry; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D051381:Rats; D011916:Rats, Inbred F344; D059016:Tumor Microenvironment
chemical_list: C576046:6-trifluoromethylpyridoxine; D007202:Indicators and Reagents; D005461:Fluorine; D011736:Pyridoxine