title: [Pharmacokinetics effect of shaoyao gancao compound with different decocting methods on characteristic ingredients in rat plasma after oral administration].
abstract: OBJECTIVE
  To observe the pharmacokinetic effect of Shaoyao Gancao compound on rats using different decocting methods, and to pharmacokinetically detect the the compatibility of the component compounds of the Shaoyao Gancao compound from the pharmacokinetic viewpoint.
  
  
  METHODS
  Based on the established HPLC analytical method of plasma effective constituents, rats were orally administered with a single or mixed decoction of Shaoyao and Gancao. Blood at different times after administering these decoctions were collected, and then variance analysis was made for pharmacokinetic parameters.
  
  
  RESULTS
  The results of all six rats indicated that the absorption of the mixed decoction of Shaoyao and Gancao was greater than that of the single decoction. While, the absorption of the characteristic peaks at the retention time of 5.2, 11.0, 12.0, 14.6 min had statistical significance.
  
  
  CONCLUSIONS
  Shaoyao Gancao compound was proved better than that of the single decoction from the pharmacokinetic viewpoint.
authors: Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. alansusu@sina.com
authors: Lan
authors: L
authors: Shen
authors: Rongwan
authors: R
authors: Hu
authors: Xiao
authors: X
authors: Lin
authors: Yanlong
authors: Y
authors: Hong
authors: Yi
authors: Y
authors: Feng
authors: Desheng
authors: D
authors: Xu
authors: Kefeng
authors: K
authors: Ruan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D029596:Paeonia / Q000737:chemistry*; D010949:Plasma / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal