title: Role of host cell factor-1 in cell cycle regulation.
abstract: Host cell factor-1(HCF-1) was first discovered as a cellular cofactor in the VP16-induced complex, a multi-protein DNA complex that forms on immediate early gene promoters of herpes simplex virus (HSV) to activate viral gene transcription. Subsequent research has revealed HCF-1 to be an abundant chromatin-associated protein that regulates various stages of the cell cycle. Recent reports show that HCF-1 interacts with diverse E2F proteins to induce cell-cycle-specific transcription. HCF-1 can act as a scaffold to a variety of histone-modifying proteins and these HCF-1-E2F-containing multi-protein complexes can bring about context-dependent activation or repression of transcription. In this review we examine the diversity of HCF-E2F interactions and the variety of multi-protein complexes it occurs in, to influence the local chromatin landscape at the E2F-promoters.
authors: Centre for DNA Fingerprinting and Diagnostics, Hyderabad , India.
authors: Zaffer
authors: Z
authors: Zargar
authors: Shweta
authors: S
authors: Tyagi
mesh_terms: D000818:Animals; D001665:Binding Sites; D002453:Cell Cycle / Q000502:physiology*; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D051863:Host Cell Factor C1 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D021122:Protein Subunits / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; D051863:Host Cell Factor C1; D021122:Protein Subunits