title: Fluoxetine is a potent inhibitor of coxsackievirus replication.
abstract: No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.
authors: Department of Pediatrics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA.
authors: Jun
authors: J
authors: Zuo
authors: Kevin K
authors: KK
authors: Quinn
authors: Steve
authors: S
authors: Kye
authors: Paige
authors: P
authors: Cooper
authors: Robert
authors: R
authors: Damoiseaux
authors: Paul
authors: P
authors: Krogstad
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004770:Enterovirus / Q000187:drug effects* / Q000254:growth & development; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D057166:High-Throughput Screening Assays; D006801:Humans; D020128:Inhibitory Concentration 50; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D054852:Small Molecule Libraries / Q000494:pharmacology; D014162:Transfection; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D000998:Antiviral Agents; D012367:RNA, Viral; D054852:Small Molecule Libraries; D005473:Fluoxetine; D049452:Green Fluorescent Proteins; C036139:norfluoxetine