title: Syntheses, properties and cellular studies of metalloisoporphyrins.
abstract: b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature.
authors: Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
authors: Sandra C
authors: SC
authors: Mwakwari
authors: Haijun
authors: H
authors: Wang
authors: Timothy J
authors: TJ
authors: Jensen
authors: M Graça H
authors: MG
authors: Vicente
authors: Kevin M
authors: KM
authors: Smith