title: [Reversible immunosuppression, liver and kidney markers, calcium and phosphorus in the healthy rabbit].
abstract: OBJECTIVE
  The aim of this study was to determine one or several doses of Methylprednisolone ( MP) who leads a long time of immunosuppression without disrupting phosphor and calcium, liver and kidney markers at the healthy rabbit.
  
  
  METHODS
  This study was made to fifteen rabbit. Five (5) batches were constituted according to Nacl and Methylpredmisolone administered dose by body weight. Control batch ( Nacl 0,9%); batch I (2,5mg / kg MP); batch II ( 5mg / kg MP); batch III ( 10mg / kg MP) and batch IV ( 15 mg / kg MP). Biochemical parameters were measured by chemical and enzymatic methods.
  
  
  RESULTS
  The results of this study showed an immunosuppression during seven days with 10 and 15 mg / kg of MP doses (P < 0.05). The biochemical disturbances were only observed with 15 mg / kg dose where calcium was lowered to day 15 and TGO increased to day 3 according to day 0 (P < 0.05).
  
  
  CONCLUSIONS
  This study showed that the doses which lead a long time of immunosuppression ( 7 days) are 10 and 15 mg / kg of MP, then the dose which does not disrupt the biochemical parameters is 10 mg / kg of MP.
authors: Laboratoire de Pharmacodynamie-Biochimique, UFR Biosciences, Universite de Cocody-Abidjan, Cote d’Ivoire, Abidjan. felhouph@yahoo.fr
authors: Félix
authors: F
authors: Yapi Houphouet
authors: Adou
authors: A
authors: Yapo
authors: Dit Phillipe
authors: DP
authors: Bidié Alain
authors: Hugues
authors: H
authors: Ahiboh
authors: Eric
authors: E
authors: Yayo
authors: Marie-Laure
authors: ML
authors: Hauhouot-Attounbre
authors: Angèle
authors: A
authors: Nguessan-Edjeme
authors: Dagui
authors: D
authors: Monnet
authors: Allico Joseph
authors: AJ
authors: Djaman
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000008:administration & dosage*; D007165:Immunosuppression Therapy; D008775:Methylprednisolone / Q000008:administration & dosage*; D010758:Phosphorus / Q000097:blood; D011817:Rabbits; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D005938:Glucocorticoids; D010758:Phosphorus; D014508:Urea; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002118:Calcium; D008775:Methylprednisolone