title: Effect of basic fibroblast growth factor on root resorption after delayed autotransplantation of tooth in dogs.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of basic fibroblast growth factor (FGF-2) on root resorption after delayed autotransplantation in dogs.
  
  
  METHODS
  Mandibular second and third premolars of beagle dogs were extracted to create sites for autotransplantation. After 2 months, in the experimental sites the first and fourth mandibular premolars were extracted and air dried before autotransplantation with the application of recombinant FGF-2; the control sites received teeth without FGF-2. At 2, 4, or 8 weeks after surgery, the animals were killed and specimens collected and processed for histologic examination.
  
  
  RESULTS
  Autotransplantation with FGF-2 yielded formation of new periodontal ligament-like tissues with inserting collagen fibers, associated cementum, and bone. The occurrence of replacement resorption in the FGF-2 treated group was significantly lower than in the control group (P < .01).
  
  
  CONCLUSIONS
  It was demonstrated that topical application of FGF-2 reduced the occurrence of ankylosis and root resorption after delayed autotransplantation in this experimental model.
authors: Department of Periodontology, Tokyo Dental College, Chiba, Japan.
authors: Satoru
authors: S
authors: Shiratani
authors: Mikio
authors: M
authors: Ota
authors: Takahisa
authors: T
authors: Fujita
authors: Fumi
authors: F
authors: Seshima
authors: Satoru
authors: S
authors: Yamada
authors: Atsushi
authors: A
authors: Saito
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D004285:Dogs; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology / Q000627:therapeutic use*; D010513:Periodontal Ligament / Q000187:drug effects / Q000254:growth & development; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D012391:Root Resorption / Q000209:etiology / Q000517:prevention & control*; D014070:Tooth / Q000637:transplantation*; D020254:Tooth Ankylosis / Q000209:etiology / Q000517:prevention & control; D014090:Tooth Replantation / Q000009:adverse effects; D014182:Transplantation, Autologous / Q000009:adverse effects
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016222:Fibroblast Growth Factor 2