title: TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.
abstract: OBJECTIVE
  In experimental studies, lysyl oxidase like-1 (LOX-L1) (-/-) mice were shown to have similar pelvic floor dysfunction to female rats. LOX-L1 levels in endopelvic fascia decrease as a result of increasing births in women with pelvic prolapse. For these reasons, we investigated the LOX-L1 gene polymorphism, which has an important role in connective tissue and collagenous metabolism in stress urinary incontinence (SUI).
  
  
  METHODS
  A total of 87 women with SUI who underwent normal vaginal delivery and 87 controls were involved in the study. Single nucleotide gene polymorphisms in LOX-L1's rs1048661, G>T, pArg141Leu, Exon-1 SmaI; rs3825942, C>T, pGly153Asp, Hinf-1 and rs2165241, C>T, İntron-1 BsrI regions were searched. The results were statistically compared as alleles with 3×2 χ(2) -test.
  
  
  RESULTS
  A total of 32 (34%) GG, 20 (21%) GT, 42 (45%) TT, 32 (37%) GG, 43 (39%) GT, 21 (24%) TT polymorphisms in rs1048661; 30 (36%) CC, 16 (19%) CT, 37 (45%) TT, 41 (59%) CC, 15 (22%) CT, 13 (19%) TT polymorphisms in rs2165241; and 63 (72%) CC, 21 (24%) CT, 3 (4%) TT; 48 (6%) CC, 22 (30%) CT, 3 (4%) TT polymorphisms in rs3825942 were found in patients and the control group, respectively. In patients, the TT polymorphism in the rs1048661 and rs2165241 region were found to be significant.
  
  
  CONCLUSIONS
  The homozygote TT polymorphism in the rs1048661 and rs2165241 region of LOX-L1 gene may be responsible from SUI physiopathology.
authors: Department of Urology, Okmeydani Research and Education Hospital, Istanbul Istanbul, Turkey. ozbekemin@hotmail.com
authors: Emin
authors: E
authors: Ozbek
authors: Emre Can
authors: EC
authors: Polat
authors: Levent
authors: L
authors: Ozcan
authors: Alper
authors: A
authors: Otunctemur
authors: Zeliha
authors: Z
authors: Emrence
authors: Duran
authors: D
authors: Ustek
mesh_terms: D000328:Adult; D000483:Alleles; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D036861:Delivery, Obstetric; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014550:Urinary Incontinence, Stress / Q000235:genetics*
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human