title: Gene expression profiles induced by E6 from non-European HPV18 variants reveals a differential activation on cellular processes driving to carcinogenesis.
abstract: Cervical cancer in developed countries remains as a major concern on public health policies due to incidence and mortality rates. Persistent infection with high risk human papillomavirus is a necessary etiological agent in the progression to invasive cervical carcinoma. A proposed hypothesis is the association between more aggressive HPV variants and the risk to develop cervical cancer. In order to have a global perspective in terms of cellular transcripts and molecular pathways affected by HPV18 E6 intratype variants; we conducted a genome wide analysis of gene expression. Our results show that E6 derived from non-European variants are able to up-regulate cellular transcripts associated to the hallmarks of cancer; such as cell cycle, migration, Wnt pathway and mTor signaling. Moreover, we were able to show that HPV18 E6 from African variant had a major effect on cellular processes such as cell cycle and migration as confirmed by functional studies.
authors: Laboratorio de Genómica, Instituto Nacional de Cancerología. Av. San Fernando 22, Col. Sección XVI, CP 14080 Tlalpan, DF, Mexico. ontiverosfvero@yahoo.com.mx
authors: Verónica
authors: V
authors: Fragoso-Ontiveros
authors: Rosa
authors: R
authors: María Alvarez-García
authors: Adriana
authors: A
authors: Contreras-Paredes
authors: Felipe
authors: F
authors: Vaca-Paniagua
authors: Luis
authors: L
authors: Alonso Herrera
authors: Cesar
authors: C
authors: López-Camarillo
authors: Nadia
authors: N
authors: Jacobo-Herrera
authors: Marcela
authors: M
authors: Lizano-Soberón
authors: Carlos
authors: C
authors: Pérez-Plasencia
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D052161:Human papillomavirus 18 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000821:virology; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D037521:Virulence Factors