title: Minireview: nuclear receptor and coregulator proteomics--2012 and beyond.
abstract: The focus of our decade-long National Institutes of Health-sponsored NURSA Proteomics Atlas was to catalog and understand the composition of the steady-state interactome for all nuclear receptor coregulator complexes in a human cell. In this Perspective, we present a summary of the proteomics of coregulator complexes with examples of how one might use the NURSA data for future exploitation. The application of this information to the identification of the coregulator proteins that contribute to the molecular basis of polygenic diseases is emphasized.
authors: Baylor College of Medicine, Department of Cellular Biology, One Baylor Plaza, Houston Texas 77030-3498, USA. berto@bcm.edu
authors: Bert W
authors: BW
authors: O'Malley
authors: Anna
authors: A
authors: Malovannaya
authors: Jun
authors: J
authors: Qin
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism; D056918:Nuclear Receptor Coactivators / Q000378:metabolism; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000378:metabolism; D015513:Oncogene Proteins / Q000378:metabolism; D000071617:Protein Deglycase DJ-1; D025941:Protein Interaction Mapping; D040901:Proteomics; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D056264:Sin3 Histone Deacetylase and Corepressor Complex / Q000378:metabolism; D015534:Trans-Activators
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C089320:MTA1 protein, human; D056918:Nuclear Receptor Coactivators; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D015513:Oncogene Proteins; C539738:RORA protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D015534:Trans-Activators; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1; D006655:Histone Deacetylases; D056264:Sin3 Histone Deacetylase and Corepressor Complex