title: Bergmann glial AMPA receptors are required for fine motor coordination.
abstract: The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
authors: Department of Molecular Physiology, University of Saarland, Homburg, Germany.
authors: Aiman S
authors: AS
authors: Saab
authors: Alexander
authors: A
authors: Neumeyer
authors: Hannah M
authors: HM
authors: Jahn
authors: Alexander
authors: A
authors: Cupido
authors: Antonia A M
authors: AA
authors: Šimek
authors: Henk-Jan
authors: HJ
authors: Boele
authors: Anja
authors: A
authors: Scheller
authors: Karim
authors: K
authors: Le Meur
authors: Magdalena
authors: M
authors: Götz
authors: Hannah
authors: H
authors: Monyer
authors: Rolf
authors: R
authors: Sprengel
authors: Maria E
authors: ME
authors: Rubio
authors: Joachim W
authors: JW
authors: Deitmer
authors: Chris I
authors: CI
authors: De Zeeuw
authors: Frank
authors: F
authors: Kirchhoff
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000648:ultrastructure; D002525:Cerebellar Cortex / Q000166:cytology* / Q000254:growth & development / Q000502:physiology; D003215:Conditioning, Eyelid; D019706:Excitatory Postsynaptic Potentials; D008124:Locomotion; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity; D016501:Neurites / Q000502:physiology / Q000648:ultrastructure; D018408:Patch-Clamp Techniques; D011597:Psychomotor Performance; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology; D018091:Receptors, AMPA / Q000378:metabolism*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure; D009435:Synaptic Transmission
chemical_list: D018091:Receptors, AMPA; C104724:glutamate receptor ionotropic, AMPA 4