title: Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast.
abstract: Benign papillary lesions of the breast include papilloma and papillomatosis. A retrospective analysis of patients with a papillary breast lesion diagnosed between October 1992 and December 2009 was performed. Patients were excluded if they had a previous or concurrent diagnosis of invasive or in situ cancer or less than 6 months of follow-up. The Kaplan-Meier method was used to determine the risk of developing subsequent malignancy. The log rank test was used to compare groups of patients. Median follow-up for the 167 patients included in the study was 4.6 years. Fifty-one patients had a papillary lesion with atypia and 116 patients had a papillary lesion without atypia. Patients with a papillary lesion with atypia were more likely to develop invasive or in situ breast cancer with a 5 year risk of 13.0% versus 4.6% in patients with no atypia (p = 0.03).
authors: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors: Kyle C
authors: KC
authors: Cuneo
authors: Rajesh C
authors: RC
authors: Dash
authors: Lee G
authors: LG
authors: Wilke
authors: Janet K
authors: JK
authors: Horton
authors: Bridget F
authors: BF
authors: Koontz
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D042361:Mammary Glands, Human / Q000473:pathology*; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology*; D012189:Retrospective Studies