title: A review on an update of NS5B polymerase hepatitis C virus inhibitors.
abstract: BACKGROUND
  Hepatitis C virus (HCV) infection is widespread, abhorrently under-diagnosed, and radically under-treated. Globally, infection with HCV is a major cause of acute hepatitis and chronic liver disease. Therefore, novel HCV inhibitors are required for the treatment of the HCV infected patients.
  
  
  OBJECTIVE
  This review gives the detailed knowledge of upcoming therapy such as NS5B polymerase inhibitors that are urgently needed.
  
  
  CONCLUSIONS
  In the past decade, intensive hard work has focused on the discovery of both structural and nonstructural inhibitors of the HCV NS5B polymerase. These demanding efforts have resulted in various promising agents advancing in clinical development with emphasis on clinical efficacy and impact for future combination studies.
authors: Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Bypass Crossing, Delhi-Haridwar Highway, NH-58, Meerut, UP, India. jonishvarshney@gmail.com
authors: J
authors: J
authors: Varshney
authors: P K
authors: PK
authors: Sharma
authors: A
authors: A
authors: Sharma
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use*; D015195:Drug Design; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000254:growth & development; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D015394:Molecular Structure; D012367:RNA, Viral / Q000097:blood; D013329:Structure-Activity Relationship; D016896:Treatment Outcome; D019562:Viral Load; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase