title: Trajectories and predictors of symptom occurrence, severity, and distress in prostate cancer patients undergoing radiation therapy.
abstract: BACKGROUND
  Radiation therapy (RT) is a common treatment for prostate cancer. Despite available research, prostate cancer patients report that information about side effects is their most important unmet need. Additional research is needed that focuses on specific dimensions of the patient's symptom experience.
  
  
  OBJECTIVE
  The study's purposes were to evaluate the trajectories of occurrence, severity, and distress of the six most prevalent symptoms reported by patients undergoing RT for prostate cancer and the effects of selected demographic and clinical characteristics on these trajectories.
  
  
  METHODS
  Patients completed the Memorial Symptom Assessment Scale 11 times before, during, and after RT. For problems with urination, pain, lack of energy, feeling drowsy, difficulty sleeping, and diarrhea, the trajectories of occurrence, severity, and distress were evaluated using multilevel generalized linear models.
  
  
  RESULTS
  Across all three dimensions, pain, lack of energy, feeling drowsy, and difficulty sleeping followed a decreasing linear trend. Problems with urination and diarrhea demonstrated more complex patterns of change over time.
  
  
  CONCLUSIONS
  Although longitudinal data on pain, lack of energy, feeling drowsy, and difficulty sleeping are limited, they are highly prevalent symptoms in these patients. In addition, diarrhea becomes a significant problem for these patients over the course of RT. A number of demographic and clinical characteristics affect the trajectories of these common symptoms differentially.
authors: School of Nursing, University of California at San Francisco, CA 94143, USA.
authors: Katie
authors: K
authors: Knapp
authors: Bruce
authors: B
authors: Cooper
authors: Theresa
authors: T
authors: Koetters
authors: Janine
authors: J
authors: Cataldo
authors: Anand
authors: A
authors: Dhruva
authors: Steven M
authors: SM
authors: Paul
authors: Claudia
authors: C
authors: West
authors: Bradley E
authors: BE
authors: Aouizerat
authors: Christine
authors: C
authors: Miaskowski
mesh_terms: D000368:Aged; D005221:Fatigue / Q000209:etiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects*; D012720:Severity of Illness Index; D063189:Symptom Assessment