title: Control of DNA capture by nanofluidic transistors.
abstract: We report the use of an array of electrically gated ~200 nm solid-state pores as nanofluidic transistors to manipulate the capture and passage of DNA. The devices are capable of reversibly altering the rate of DNA capture by over 3 orders of magnitude using sub-1 V biasing of a gate electrode. This efficient gating originates from the counter-balance of electrophoresis and electroosmosis, as revealed by quantitative numerical simulations. Such a reversible electronically tunable biomolecular switch may be used to manipulate nucleic acid delivery in a fluidic circuit, and its development is an important first step toward active control of DNA motion through solid-state nanopores for sensing applications.
authors: Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA.
authors: Kee-Hyun
authors: KH
authors: Paik
authors: Yang
authors: Y
authors: Liu
authors: Vincent
authors: V
authors: Tabard-Cossa
authors: Matthew J
authors: MJ
authors: Waugh
authors: David E
authors: DE
authors: Huber
authors: J
authors: J
authors: Provine
authors: Roger T
authors: RT
authors: Howe
authors: Robert W
authors: RW
authors: Dutton
authors: Ronald W
authors: RW
authors: Davis
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification* / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008846:Micromanipulation / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D014173:Transistors, Electronic
chemical_list: D004247:DNA