title: A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing.
abstract: DNA methylome analysis in a variety of species has revealed elevated 5-methylcytosine at exons relative to introns. These associations raised the possibility that intragenic DNA methylation aids the spliceosome in the process of exon definition. Here, I highlight recent genome-wide associations and direct evidence linking DNA methylation to pre-mRNA splicing.
authors: Mouse Cancer Genetics Program, NCI-Frederick, NIH, Frederick, MD USA. Shalini.oberdoerffer@nih.gov
authors: Shalini
authors: S
authors: Oberdoerffer
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism; D017398:Alternative Splicing; D019175:DNA Methylation; D005091:Exons; D020869:Gene Expression Profiling / Q000379:methods; D056726:Genetic Association Studies / Q000379:methods; D015894:Genome, Human; D006801:Humans; D007438:Introns; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D044503:5-Methylcytosine