title: Pulpal and periapical response after restoration of deep cavities in dogs' teeth with Filtek Silorane and Filtek Supreme XT systems.
abstract: OBJECTIVE
  This study evaluated, histopathologically, the pulpal and periapical response to a silorane-based resin (Filtek Silorane) and a methacrylate-based nanoparticle resin (Filtek Supreme XT) in deep cavities in dogs, having zinc oxide and eugenol-based cement (ZOE) as a control.
  
  
  METHODS
  The tooth/bone blocks were collected after 10 and 90 days and processed for microscopic analysis of the dentin, pulp, and periapical tissues using a score system. Data were analyzed statistically by Kruskal-Wallis and Dunn post-test (α=0.05).
  
  
  RESULTS
  At 10 days, the pulp, connective tissue, and periodontal ligament showed normal characteristics. No resorption areas were observed. Both resins caused significantly less (p<0.05) periapical and pulpal inflammatory response than ZOE. At 90 days, for all materials, the connective pulp tissue was healthy and dense, with a normal blood vessel system. The apical and periapical region had normal structure and thickness.
  
  
  CONCLUSIONS
  The use of the Filtek Silorane and the Filtek Supreme XT resins caused no adverse pulpal and periapical reactions after restoration of deep dentin cavities in vivo.
authors: Catalan Societey of Dentistry and Stomatology, Academy of Medical Sciences and Health of Catalonia and Balears, Barcelona, Spain.
authors: E
authors: E
authors: Ruiz-de-Castañeda
authors: P
authors: P
authors: Gatón-Hernández
authors: E G
authors: EG
authors: Rodriguez
authors: R A B
authors: RA
authors: Silva
authors: P
authors: P
authors: Nelson-Filho
authors: L A B
authors: LA
authors: Silva
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000473:pathology; D003188:Composite Resins / Q000737:chemistry*; D003238:Connective Tissue / Q000473:pathology; D003731:Dental Caries / Q000628:therapy*; D003737:Dental Cavity Preparation / Q000145:classification; D003739:Dental Cementum / Q000473:pathology; D003764:Dental Materials / Q000737:chemistry*; D003782:Dental Pulp / Q000098:blood supply / Q000473:pathology*; D003786:Dental Pulp Cavity / Q000473:pathology; D003789:Dental Pulp Exposure / Q000473:pathology; D003793:Dental Restoration, Permanent / Q000145:classification*; D003804:Dentin / Q000473:pathology; D004285:Dogs; D005347:Fibroblasts / Q000473:pathology; D008768:Methylmethacrylates / Q000737:chemistry; D009804:Odontoblasts / Q000473:pathology; D010486:Periapical Tissue / Q000473:pathology*; D010513:Periodontal Ligament / Q000473:pathology; D016300:Radiography, Bitewing; D011897:Random Allocation; D062047:Silorane Resins / Q000737:chemistry*; D013997:Time Factors; D015035:Zinc Oxide-Eugenol Cement / Q000737:chemistry
chemical_list: D003188:Composite Resins; D003764:Dental Materials; C474035:Filtek Supreme; D008768:Methylmethacrylates; D062047:Silorane Resins; D015035:Zinc Oxide-Eugenol Cement; C555513:silorane composite resin; C031667:IRM cement