title: InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.
abstract: A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl(3) with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules.
authors: Cosmic Discoveries, Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, India. naveen071280@gmail.com
authors: Naveen
authors: N
authors: Mulakayala
authors: Bhaskar
authors: B
authors: Kandagatla
authors: Ismail
authors: Rajesh Kumar
authors: RK
authors: Rapolu
authors: Pallavi
authors: P
authors: Rao
authors: Chaitanya
authors: C
authors: Mulakayala
authors: Chitta Suresh
authors: CS
authors: Kumar
authors: Javed
authors: J
authors: Iqbal
authors: Srinivas
authors: S
authors: Oruganti
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001665:Binding Sites; D002384:Catalysis; D020134:Catalytic Domain; D045744:Cell Line, Tumor; D003198:Computer Simulation; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007204:Indium / Q000737:chemistry*; D020014:K562 Cells; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D056564:Sirtuin 1 / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011744:Pyrimidinones; D052999:Quinazolinones; D007204:Indium; C020758:indium trichloride; C447939:SIRT1 protein, human; D056564:Sirtuin 1