title: Response to topical clonazepam in patients with burning mouth syndrome: a clinical study.
abstract: Burning Mouth Syndrome (BMS) is a difficult disease for patients and clinicians. Moreover, there is not a general consensus on how to treat the disease. The main objective of this paper is to evaluate BMS patients' response to topical clonazepam treatment. A double blind study was performed. Among a total of 66 patients, 33 were treated with tablets of clonazepam and another 33 were treated with a placebo. Symptoms were evaluated after 1 month and 6 months of treatment and scored on an analogical scale from 0 to 10. Among the 33 patients treated with clonazepam, 23 showed at least a 50% reduction in symptoms after 1 month of treatment. On the contrary, only 4 in the placebo group exhibited significant improvement. After 6 months, significant differences were observed again, as 23 of the 33 patients treated with the drug reported at least a 50% reduction in symptoms, whereas only 2 among those treated with the placebo significantly improved. However, when measured in terms of a complete cure (lack of symptoms), the differences were not significant: 5 drug-treated patients and one belonging to the placebo group were asymptomatic after one month of treatment. In summary, it seems that clonazepam applied topically was effective in treating BMS in a large proportion of patients.
authors: Dentistry Department, Faculty of Dentistry, University of Barcelona, Spain.
authors: E
authors: E
authors: Rodríguez de Rivera Campillo
authors: J
authors: J
authors: López-López
authors: E
authors: E
authors: Chimenos-Küstner
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D002054:Burning Mouth Syndrome / Q000188:drug therapy*; D016009:Chi-Square Distribution; D002998:Clonazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D018757:GABA Modulators / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D010147:Pain Measurement; D016896:Treatment Outcome
chemical_list: D018757:GABA Modulators; D009067:Mouthwashes; D002998:Clonazepam