title: An efficient three-component, one-pot synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines in water.
abstract: A convenient and practical method for the synthesis of 2-alkylthio-4-amino-5-cyano-6-aryl(alkyl)pyrimidines has been developed via a three-component, one-pot reaction from aldehydes, malononitrile and S-alkylisothiouronium salts in water at room temperature. A series of polysubstituted pyrimidines were prepared by this method in moderate to excellent yields. In addition, two kinds of pyrimidine-fused heterocyclic derivatives with potential pharmacological activity were constructed from our 2-alkylthio-4-amino-5-cyano-6-arylpyrimidines.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
authors: Qiao-Yan
authors: QY
authors: Li
authors: Ze-Mei
authors: ZM
authors: Ge
authors: Tie-Ming
authors: TM
authors: Cheng
authors: Run-Tao
authors: RT
authors: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D009570:Nitriles / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D009570:Nitriles; D011743:Pyrimidines; D014867:Water; C000945:dicyanmethane