title: Antibacterial hemostatic dressings with nanoporous bioglass containing silver.
abstract: Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m(2)/g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS's clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.
authors: The First People's Hospital of Xiaoshan, Hangzhou, China. gangfenghu@yahoo.cn
authors: Gangfeng
authors: G
authors: Hu
authors: Luwei
authors: L
authors: Xiao
authors: Peijian
authors: P
authors: Tong
authors: Dawei
authors: D
authors: Bi
authors: Hui
authors: H
authors: Wang
authors: Haitao
authors: H
authors: Ma
authors: Gang
authors: G
authors: Zhu
authors: Hui
authors: H
authors: Liu
mesh_terms: D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001458:Bandages; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy; D006489:Hemostatic Techniques / Q000295:instrumentation; D006490:Hemostatics / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D058608:Nanopores; D010316:Particle Size; D016062:Porosity; D011817:Rabbits; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry; D012867:Skin / Q000293:injuries
chemical_list: D000900:Anti-Bacterial Agents; C022107:Bioglass; D006490:Hemostatics; D012834:Silver