title: Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues.
abstract: Stearic acid, a saturated fatty acid was isolated from the microalga Spirulina platensis. Some novel stearic acid analogues having 1,3,4-oxadiazole, 1,2,4-triazole and 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole are synthesized and characterized by IR, NMR and mass spectral analysis. All the synthesized compounds were screened for antimicrobial activity by using cup plate method. The synthesized compounds have been further screened for their antidepressant activity in swiss albino mice by forced swim test (FST), midbrain dopamine has been estimated and quantified. All the compounds showed good antimicrobial activity and compound 6 showed significant antidepressant activity.
authors: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rock lands, Ooty 643 001, Tamilnadu, India. jubiejawahar@gmail.com
authors: Selvaraj
authors: S
authors: Jubie
authors: Patil Nilesh
authors: PN
authors: Ramesh
authors: Palanichamy
authors: P
authors: Dhanabal
authors: Rajagopal
authors: R
authors: Kalirajan
authors: Nithyanantham
authors: N
authors: Muruganantham
authors: Anthoniswamy Shanish
authors: AS
authors: Antony
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004298:Dopamine / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D008297:Male; D051379:Mice; D013229:Stearic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013550:Swimming
chemical_list: D000890:Anti-Infective Agents; D000928:Antidepressive Agents; D013229:Stearic Acids; C031183:stearic acid; D004298:Dopamine