title: A strategy for promoting bone regeneration by inducible expression of 15-LOX-1.
abstract: Repairing large bone defects is a major orthopaedic problem, with current treatments being constrained by the regenerative capacity of human tissue. Current methods for repairing bone defects include osteogenesis, osteoconduction, osteoinduction, and tissue engineering; however, the cumulative effect of these methods is, as of yet, rather unsatisfactory. Recent research has demonstrated that knockout of the cell cycle inhibitor p21, which works as a switch to control regenerative capacity, can promote cell proliferation and appendage regeneration. The enzyme 15-lipoxygenase type 1 (15-LOX-1), which is involved in arachidonic and linoleic acid metabolism, has the potential to down-regulate the expression of p21. Therefore, we hypothesise that the construction of a new bone substitute that expresses 15-LOX-1 locally will promote osteoblast proliferation through inhibition of p21, resulting in an effective and inducible method for promoting bone regeneration.
authors: Department of Orthopaedics, Southwest Hospital, The Third Military Medical University, Chongqing, China.
authors: Hao
authors: H
authors: Pang
authors: Xue-hui
authors: XH
authors: Wu
authors: Jian-zhong
authors: JZ
authors: Xu
mesh_terms: D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D001861:Bone Regeneration; D006801:Humans; D008962:Models, Theoretical
chemical_list: D001093:Arachidonate 15-Lipoxygenase