title: A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds.
abstract: BACKGROUND
  Data regarding several hyaluronic acids (HAs) used identically for facial tissue augmentation have heretofore been unavailable.
  
  
  OBJECTIVE
  This prospective, split-face, randomized, two-armed study sought to determine the long-term safety and effectiveness of three HAs (HA-1 (Belotero Basic/Balance), HA-2 (Restylane), and HA-3 (Juvéderm Ultra 3/Juvéderm Ultra Plus XC) in the treatment of nasolabial folds (NLFs).
  
  
  METHODS
  Twenty participants in Arm A received HA-1 in one NLF and HA-2 in the other. In Arm B, 20 participants received HA-1 in one NLF and HA-3 in the other. Injection was at visit 2, with follow-up visits at 1, 6, 9, and 12 months. Mean volume of HA was slightly <1.5 mL/NLF.
  
  
  RESULTS
  Adverse events were unremarkable across all HAs, with injection site erythema being the most frequent adverse event. Mean pretreatment NLF severity rating for both arms was 2.3; at 12 months, mean posttreatment severity rating was 1.5 for HA-1/HA-2 and 1.6 for HA-1/HA-3. Although not statistically significant, participants tended to show a preference for HA-1.
  
  
  CONCLUSIONS
  All three HAs provided essentially equivalent results, except for 4-week evenness results, which favored HA-1. Injection volumes of the three HAs were also similar.
authors: Dermatologikum, Hamburg, Germany. prager@dermatologikum.de
authors: Welf
authors: W
authors: Prager
authors: Esther
authors: E
authors: Wissmueller
authors: Isabel
authors: I
authors: Havermann
authors: Eva K
authors: EK
authors: Bee
authors: David J
authors: DJ
authors: Howell
authors: Ina
authors: I
authors: Zschocke
authors: Jeannette
authors: J
authors: Simon
mesh_terms: D003357:Cosmetic Techniques; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D007271:Injections, Intradermal; D060052:Nasolabial Fold / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: C526061:Juvederm Ultra; D006820:Hyaluronic Acid; C445361:Restylane