title: Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety.
abstract: Series of novel derivatives of quinazoline containing thiosemicarbazide moiety 5 and 9 have been synthesized and tested for their antitumor activities in vitro against a panel of five human cancer cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various cancer cells. From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their antitumor activity.
authors: Key Laboratory of Pesiticide & Chemistry Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China.
authors: Junbo
authors: J
authors: He
authors: Xiaoguo
authors: X
authors: Wang
authors: Xiaoqin
authors: X
authors: Zhao
authors: Yongju
authors: Y
authors: Liang
authors: Hongwu
authors: H
authors: He
authors: Liwu
authors: L
authors: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012663:Semicarbazides / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D012663:Semicarbazides; C005151:thiosemicarbazide