title: Eryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotus eryngii.
abstract: Eryngiolide A (1), the first member of C20 diterpenoids with the skeleton deriving from a cyclododecane core fused with two γ-lactone units, was isolated from the solid culture of the edible mushroom Pleurotus eryngii. The structure of 1 was elucidated by extensive analysis of NMR spectra. Compound 1 exhibited moderate cytotoxicity against two human cancer lines in vitro.
authors: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , No. 9 Beiertiao, Zhongguancun, Haidian District, Beijing 100190, People's Republic of China, and College of Pharmacy, Soochow University , No. 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, People's Republic of China.
authors: Shao-juan
authors: SJ
authors: Wang
authors: Yong-xia
authors: YX
authors: Li
authors: Li
authors: L
authors: Bao
authors: Jun-jie
authors: JJ
authors: Han
authors: Xiao-li
authors: XL
authors: Yang
authors: He-ran
authors: HR
authors: Li
authors: Ya-qi
authors: YQ
authors: Wang
authors: Shao-jie
authors: SJ
authors: Li
authors: Hong-wei
authors: HW
authors: Liu
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020076:Pleurotus / Q000737:chemistry*
chemical_list: D004224:Diterpenes; C000588481:eryngiolide A