title: Oxidized low density lipoprotein, stem cells, and atherosclerosis.
abstract: Oxidized low density lipoprotein (ox-LDL), a risk factor of atherosclerosis, facilitates the formation and vulnerability of atherosclerotic plaque, thus contributing to several clinical complications. Stem cells participate in vascular repair after damage and atherosclerosis is a process of inflammation accompanied with vascular injury. Researchers have proposed that stem cells participate in the formation of atherosclerotic plaque. Also, because ox-LDL is capable of inducing toxic effects on stem cells, it is reasonable to postulate that ox-LDL promotes the progress of atherosclerosis via acting on stem cells. In the present article, we review the relationship between ox-LDL, stem cells, and atherosclerosis and a portion of the associated mechanisms.
authors: Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors: Hui
authors: H
authors: Yang
authors: Ahmed Salah Salem
authors: AS
authors: Mohamed
authors: Sheng-Hua
authors: SH
authors: Zhou
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D008077:Lipoproteins, LDL / Q000378:metabolism / Q000502:physiology*; D018384:Oxidative Stress; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein