title: Identification of ankylosing spondylitis-associated genes by expression             profiling.
abstract: Ankylosing spondylitis (AS) is a chronic inflammation attacking the sacroiliac             joints and the spine. Certain genes have been associated with the occurrence of             AS. Gene chip data were utilized to recognize genes associated with AS for the             association of the clinical diagnosis and the biomedical study. Microarray expression             data of AS were acquired from the public microarray database GEO (gene expression             omnibus), and AS-related genes were obtained by differential gene expression profiling.             The transcriptional and translational levels of these genes were further examined.             The transcriptional and translational levels of three genes were shown to be upregulated             in a mouse model of AS by real-time PCR and Elisa assay, respectively. Differential             expression of AS-related genes was identified by analysis of gene chip data, contributing             to the advancement of the understanding of the pathogenesis of AS.
authors: Department of Orthopaedics, Changhai Hospital, Second Military                     Medical University, Shanghai, P.R. China.
authors: Hui
authors: H
authors: Ma
authors: Dabo
authors: D
authors: Xu
authors: Qiang
authors: Q
authors: Fu
mesh_terms: D000818:Animals; D060908:CTLA-4 Antigen / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D051379:Mice; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000378:metabolism
chemical_list: D060908:CTLA-4 Antigen