title: [The immune stressor effects of T-regulatory cells under infiltrative tuberculosis of lungs].
abstract: The article deals with the characteristics of sup-population composition of T-regulator: cells with suppressor activity and production of immunoregulatory cytokines suppressing immune response (IL-10, TGF-beta) in patients with infiltrative tuberculosis of lungs. It is proved that the leading role in formation of immunodepression and tuberculin anergy under infiltrative tuberculosis of lungs is played by T-regulatory, cells with phenotype CD4+CD25+Foxp3+. It is demonstrated that the immunodepression mediated by cytokine production is connected with increasing of both basal and BCG-induced secretion of IL-10 on the background of decrease of level of production of TGF-beta by mononuclear leukocytes in vitro.
authors: E G
authors: EG
authors: Churina
authors: O I
authors: OI
authors: Urazova
authors: V V
authors: VV
authors: Novitskiĭ
authors: A E
authors: AE
authors: Kolosova
authors: E V
authors: EV
authors: Sionina
authors: O V
authors: OV
authors: Filiniuk
authors: O V
authors: OV
authors: Voronkova
authors: I O
authors: IO
authors: Naslednikova
mesh_terms: D000293:Adolescent; D000328:Adult; D017635:Clonal Anergy; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000276:immunology*; D014373:Tuberculin / Q000008:administration & dosage / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology
chemical_list: C508609:IL10 protein, human; D016212:Transforming Growth Factor beta; D014373:Tuberculin; D016753:Interleukin-10