title: Optimized outcomes for renal allografts with cold ischemic times of 20 h or greater.
abstract: BACKGROUND
  Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term outcomes and to determine the possible ways to optimize the use of these organs.
  
  
  METHODS
  All kidney transplants from April 2001 to December 2010 with CIT ≥ 20 h were considered. Donor and recipient data were analyzed with uni- and multivariate Cox proportional hazard analyses. Graft and patient survival were calculated using the Kaplan-Meier method.
  
  
  RESULTS
  One hundred and eighty-one patients were transplanted with 184 grafts. Median recipient age and waiting time on dialysis were 52.5 and 4.9 years, respectively. After a median follow-up of 4.9 years, 148 of 181 patients are alive, 143 of them with functioning grafts. One-, three, and five-year graft and patient survival rates were 90, 87, and 79 %, and 96, 91, and 85 %, respectively. Donor age (p < 0.0001), retransplantation (p = 0.0025), and induction therapy with interleukin-2 antagonists (p = 0.0487) were predictors of graft survival by univariate analysis. Donor age and retransplantation remained significant by multivariate analysis (p < 0.001 and p = 0.0046, respectively). Donor age (p = 0.0176) and creatinine level at 1-month post-KT (p = 0.0271) were predictors of patient survival by univariate analysis. Only donor age reached multivariate significance (p = 0.0464). The calculated donor age cut off was 60 years.
  
  
  CONCLUSIONS
  Satisfactory long-term kidney transplant outcomes in the setting of CIT ≥ 20 h can be achieved with grafts from donors <60 years in first-time recipients. Induction therapy should preferably be with an interleukin-2 antagonist.
authors: Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany.
authors: Anja
authors: A
authors: Gallinat
authors: Andreas
authors: A
authors: Paul
authors: Thomas
authors: T
authors: Minor
authors: Jürgen W
authors: JW
authors: Treckmann
authors: Ernesto P
authors: EP
authors: Molmenti
authors: Oliver
authors: O
authors: Witzke
authors: Georgios C
authors: GC
authors: Sotiropoulos
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D050377:Cold Ischemia / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000209:etiology*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012086:Reoperation; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D007376:Interleukin-2; D003404:Creatinine