title: [Effects of tadalafil on erectile dysfunction: on-demand versus once-daily dosing].
abstract: OBJECTIVE
  To evaluate the effects of tadalafil administered on demand or once a day in the treatment of erectile dysfunction (ED).
  
  
  METHODS
  We randomly assigned 61 ED patients to three groups to receive tadalafil on demand, at 5 mg once daily, and at 10 mg once daily, respectively. After 42 days of medication, we compared the therapeutic effects among different groups using the patients' sexual encounter profile (SEP) diaries, detected the adverse reactions and assessed the safety of tadalafil.
  
  
  RESULTS
  Fifty-three (86.7%) of the patients completed the investigation, and all responded well to tadalafil medication, with a significantly improved success rate of sexual intercourse and a low rate of mild adverse effects. The mean positive rates of SEP were basically similar between the on-demand and once-daily groups.
  
  
  CONCLUSIONS
  There are no significant differences in the improvement of penile erection and sexual satisfaction of ED patients treated by on-demand and once-daily administration of tadalafil.
authors: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
authors: Yu-Xin
authors: YX
authors: Tang
authors: Hua-Bo
authors: HB
authors: Zhou
authors: Sheng-Lin
authors: SL
authors: Peng
authors: Xian-Zhen
authors: XZ
authors: Jiang
authors: Le-Ye
authors: LY
authors: He
authors: Dong-Jie
authors: DJ
authors: Li
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil