title: Synthesis of 5,6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents.
abstract: Indan derivatives, namely, 5-(5',6'-dichloroindan-1'-yl)-tetrazole (12a) and 5-(5',6'-dichloroindan-1'-yl)- methyltetrazole (12b), were synthesized conveniently from 5,6-dichloroindan-1-carboxylic acid (9a) and 5,6- dichloroindan-1-acetic acid (9b), respectively, as potential analgesic and anti-inflammatory agents. The analgesic and anti-inflammatory properties of 9a, 9b, 12a and 12b were evaluated by the acetic acid induced writhing in Swiss albino mice and the carrageenan-induced rat paw edema models, respectively. Compounds 9a and 12a exhibited significant analgesic activity with the doses of 50 and 100 mg/kg body weight, comparable to that of the positive controls, phenylbutazone, indomethacin and aminopyrine. The anti-inflammatory potencies of 9a and 12a were also comparable to that of the positive control, phenylbutazone. Compounds 9b and 12b showed analgesic and anti-inflammatory activities, but were weaker than that of compounds 9a and 12a.
authors: National Institute of Health, National Institute on Aging, 251 Bayview Blvd, Suite no. 100, Room no. 9C009, Baltimore, MD 21224, USA.
authors: Rajib Kumar
authors: RK
authors: Pal
authors: Hasina
authors: H
authors: Yasmin
authors: Lutfun
authors: L
authors: Nahar
authors: Bidyut Kanti
authors: BK
authors: Datta
authors: Abul Kalam Azad
authors: AK
authors: Chowdhury
authors: Joydeb Kumar
authors: JK
authors: Kundu
authors: Sitesh Chandra
authors: SC
authors: Bachar
authors: Satyajit Dey
authors: SD
authors: Sarker
mesh_terms: D019342:Acetic Acid; D000632:Aminopyrine / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D007189:Indans; D013777:Tetrazoles; D000632:Aminopyrine; D002351:Carrageenan; D010653:Phenylbutazone; D019342:Acetic Acid; D007213:Indomethacin