title: Modafinil improves event related potentials P300 and contingent negative variation after 24 h sleep deprivation.
abstract: OBJECTIVE
  The efficacy of modafinil as a countermeasure in the reduction of cognitive decline following 24 h of sleep deprivation (SD) on subjective sleepiness scales, event-related potential (ERP) P300, and contingent negative variation (CNV) was evaluated.
  
  
  METHODS
  Eleven healthy males, age 25-30 years participated. The experiment was performed in five sessions on different days between 7 and 8a.m. Session 1, baseline recordings; Session 2, after one night's SD; Session 3, 48 h of recovery from SD; Session 4, after 1 week of Session 1, following one night's SD along with modafinil (400mg/day); Session 5, 48 h of recovery after SD+modafinil.
  
  
  RESULTS
  Subjective sleepiness scores increased significantly after SD as compared to baseline (P<0.01), but remained unaltered after modafinil supplementation. There was an increase in N100 and P300 peak latencies of ERP following SD (P<0.01), which was reduced with modafinil (P<0.05). There was an increase in CNV M100 and P300 peak latencies after SD (P<0.01) which decreased with the use of modafinil (P<0.05). The CNV reaction time increased following SD (P<0.01) and decreased with the use of modafinil (P<0.05). No significant effects on ERP N200, P200 latencies and P200, P300 amplitudes and CNV N100, M200 peak latencies and M100, M200 amplitudes were observed.
  
  
  CONCLUSIONS
  The results strongly suggest that modafinil in a dose of 400mg/day, reduces the subjective sleepiness and cognitive decline following 24 h of SD.
authors: Neurophysiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi, 110054, India.
authors: Koushik
authors: K
authors: Ray
authors: Abhirup
authors: A
authors: Chatterjee
authors: Usha
authors: U
authors: Panjwani
authors: Sanjeev
authors: S
authors: Kumar
authors: Surajit
authors: S
authors: Sahu
authors: Sayan
authors: S
authors: Ghosh
authors: Lalan
authors: L
authors: Thakur
authors: Jag Parvesh
authors: JP
authors: Anand
mesh_terms: D056044:Actigraphy / Q000379:methods; D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001835:Body Weight; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003071:Cognition; D003072:Cognition Disorders / Q000378:metabolism; D004594:Electrophysiology / Q000379:methods; D018913:Event-Related Potentials, P300; D006801:Humans; D008297:Male; D000077408:Modafinil; D015233:Models, Statistical; D009482:Neurophysiology / Q000379:methods; D012892:Sleep Deprivation; D011795:Surveys and Questionnaires; D013997:Time Factors; D014851:Wakefulness
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil