title: How do cytokines trigger genomic instability?
abstract: Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.
authors: Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece. ioaival@gmail.com
authors: Ioannis L
authors: IL
authors: Aivaliotis
authors: Ioannis S
authors: IS
authors: Pateras
authors: Marilena
authors: M
authors: Papaioannou
authors: Christina
authors: C
authors: Glytsou
authors: Konstantinos
authors: K
authors: Kontzoglou
authors: Elizabeth O
authors: EO
authors: Johnson
authors: Vassilis
authors: V
authors: Zoumpourlis
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D042822:Genomic Instability; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology
chemical_list: D016207:Cytokines