title: Prevention of cisplatin ototoxicity: Efficacy of micronized flavonoid fraction in a guinea pig model.
abstract: OBJECTIVE
  To evaluate the effectiveness of micronized flavonoid fraction in preventing cisplatin ototoxicity in a guinea pig model.
  
  
  METHODS
  This study was conducted on 23 guinea pigs in the Animal Laboratory of Izmir Atatürk Training and Research Hospital. Animals were divided into three groups: Group 1 consisted of eight animals receiving cisplatin only; Group 2 contained eight animals receiving cisplatin+micronized flavonoid fraction; and Group 3 contained seven animals that received micronized flavonoid fraction only. Their cochlear reserve was evaluated by measuring the distortion product otoacoustic emission on days 0 and 7.
  
  
  RESULTS
  In Groups 1 and 2, the intragroup signal-noise ratios were statistically different at all frequencies tested (based on negative ranks, p<0.05). In Group 3, the intragroup signal-noise ratios did not differ significantly at the frequencies tested (p>0.05). Comparison of the three groups showed statistically significant differences among the groups (p<0.05). The post hoc Bonferroni correction showed statistically significant differences among all three groups (p<0.016). The median signal-noise ratio of the three groups tended to increase (z-value was positive for all the frequencies tested; p<0.01).
  
  
  CONCLUSIONS
  Micronized flavonoid fraction (Daflon) is effective against cisplatin-induced ototoxicity in guinea pigs.
authors: Department of Otolaryngology Head & Neck Surgery, Atatürk Research and Education Hospital, İzmir, Turkey.
authors: M Sinan
authors: MS
authors: Başoğlu
authors: Erdem
authors: E
authors: Eren
authors: Hale
authors: H
authors: Aslan
authors: Aslıhan Gürcan
authors: AG
authors: Bingölballı
authors: Sedat
authors: S
authors: Oztürkcan
authors: Hüseyin
authors: H
authors: Katılmış
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects*; D004145:Diosmin / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000517:prevention & control*; D005260:Female; D005419:Flavonoids; D006168:Guinea Pigs; D017084:Otoacoustic Emissions, Spontaneous
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D004145:Diosmin; D002945:Cisplatin; C041477:3-hydroxyflavone