title: Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.
abstract: Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.
authors: Department of Neurobiology, Interdisciplinary Centre for Neurosciences, University of Heidelberg, Heidelberg, Germany.
authors: Ana M M
authors: AM
authors: Oliveira
authors: Thekla J
authors: TJ
authors: Hemstedt
authors: Hilmar
authors: H
authors: Bading
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000201:enzymology*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D019175:DNA Methylation / Q000502:physiology; D000090205:DNA Methyltransferase 3A; D006624:Hippocampus / Q000201:enzymology*; D008569:Memory Disorders / Q000201:enzymology; D057567:Memory, Long-Term / Q000502:physiology; D051379:Mice
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A