title: Subchronic feeding study of stacked trait genetically-modified soybean (3Ø5423 × 40-3-2) in Sprague-Dawley rats.
abstract: The genetically-modified (GM) soybean 3Ø5423 × 40-3-2 expresses siRNA for the fatty acid desaturase-2 enzyme which results in higher concentrations of oleic acid (18:1) relative to linoleic acid (18:2) compared with non-GM soybeans. It also expresses the CP4 EPSPS protein for tolerance to glyphosate. In this study, three different dietary concentrations (7.5%, 15% and 30% wt/wt) of 3Ø5423 × 40-3-2 or non-GM soybeans were fed to Sprague-Dawley rats for 90 days during which in-life nutritional and growth performance variables were evaluated followed by analysis of standard clinical chemistry, hematology and organ variables. Compared with rats fed the non-GM control diet, some statistically significant differences were observed in rats fed the 3Ø5423 × 40-3-2 diet. However the differences were not considered treatment-related and commonly fell within the normal ranges of the control group consuming the commercial diet. These results demonstrated that the GM soybean 3Ø5423 × 40-3-2 is as safe as non-GM soybeans.
authors: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
authors: Xiaozhe
authors: X
authors: Qi
authors: Xiaoyun
authors: X
authors: He
authors: Yunbo
authors: Y
authors: Luo
authors: Shuangying
authors: S
authors: Li
authors: Shiying
authors: S
authors: Zou
authors: Sishuo
authors: S
authors: Cao
authors: Maozhi
authors: M
authors: Tang
authors: Bryan
authors: B
authors: Delaney
authors: Wentao
authors: W
authors: Xu
authors: Kunlun
authors: K
authors: Huang
mesh_terms: D000818:Animals; D001835:Body Weight; D004032:Diet; D005247:Feeding Behavior; D009929:Organ Size; D030821:Plants, Genetically Modified; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max; D015430:Weight Gain