title: Polycomb in stem cells: PRC1 branches out.
abstract: Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
authors: Centre for Genomic Regulation (CRG) and UPF, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors: Nuno Miguel
authors: NM
authors: Luis
authors: Lluis
authors: L
authors: Morey
authors: Luciano
authors: L
authors: Di Croce
authors: Salvador Aznar
authors: SA
authors: Benitah
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism; D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D046912:Multiprotein Complexes; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins