title: Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.
abstract: Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.
authors: Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
authors: Samra
authors: S
authors: Obeid
authors: Holger
authors: H
authors: Busskamp
authors: Wolfgang
authors: W
authors: Welte
authors: Kay
authors: K
authors: Diederichs
authors: Andreas
authors: A
authors: Marx
mesh_terms: D001483:Base Sequence; D020134:Catalytic Domain; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*
chemical_list: D009711:Nucleotides; D004259:DNA-Directed DNA Polymerase