title: Chemical methods for degradation of target proteins using designed light-activatable organic molecules.
abstract: Molecular design, chemical synthesis, and biological evaluation of several designed organic molecules, which target-selectively degrade proteins upon photo-irradiation, are introduced. The designed molecules for protein photo-degradation include 2-phenylquinoline-steroid hormone hybrids and porphyrin derivatives, both of which selectively photo-degrade estrogen receptor-α, and fullerene-sugar and -sulfonic acid hybrids, which selectively photo-degrade HIV-1 protease and amyloid β, respectively. The information will provide a novel and effective way to control specific functions of proteins, and contribute to the molecular design of novel protein photo-degrading agents, which should find wide application in chemistry, biology, and medicine.
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors: Shuho
authors: S
authors: Tanimoto
authors: Daisuke
authors: D
authors: Takahashi
authors: Kazunobu
authors: K
authors: Toshima
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D047628:Estrogen Receptor alpha / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry; D016333:HIV Protease / Q000737:chemistry; D006801:Humans; D009005:Monosaccharides / Q000737:chemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000138:chemical synthesis*; D011166:Porphyrins / Q000737:chemistry; D059748:Proteolysis; D011804:Quinolines / Q000737:chemistry; D051381:Rats; D013256:Steroids / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: C541577:2-phenylquinoline; D016229:Amyloid beta-Peptides; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D037741:Fullerenes; D009005:Monosaccharides; D017319:Photosensitizing Agents; D011166:Porphyrins; D011804:Quinolines; D013256:Steroids; D013451:Sulfonic Acids; D016333:HIV Protease; C514803:p16 protease, Human immunodeficiency virus 1