title: Select agent and toxin regulations: beyond the eighth edition of the Guide for the Care and Use of Laboratory Animals.
abstract: In the interval between the publication of the seventh and eighth editions of the Guide for the Care and Use of Laboratory Animals (Guide), much has changed with regard to the regulation and funding of highly pathogenic biologic agents and toxins (Select Agents). Funding  of research involving highly pathogenic agents has increased dramatically during this time, thus increasing the demand for facilities capable of supporting this work. The eighth edition of the Guide briefly mentions Select Agents and provides a limited set of references. Here we provide  some background information regarding the relevant laws and regulations, as well as an overview of the programmatic requirements pertaining to the use of Select Agents, with a focus on use in animals.
authors: Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. rkastenmayer@niaid.nih.gov
authors: Robin J
authors: RJ
authors: Kastenmayer
authors: Rashida M
authors: RM
authors: Moore
authors: Allison L
authors: AL
authors: Bright
authors: Rafael
authors: R
authors: Torres-Cruz
authors: William R
authors: WR
authors: Elkins
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001688:Biological Products; D033161:Government Regulation; D017408:Guidelines as Topic; D006801:Humans; D012637:Security Measures / Q000331:legislation & jurisprudence*; D014118:Toxins, Biological; D014481:United States; D016885:United States Department of Agriculture / Q000331:legislation & jurisprudence; D014483:United States Dept. of Health and Human Services / Q000331:legislation & jurisprudence
chemical_list: D001688:Biological Products; D014118:Toxins, Biological