title: Cytoskeleton dynamics in early zebrafish development: A matter of phosphorylation?
abstract: Early morphogenic movements are an important feature of embryonic development in vertebrates. During zebrafish gastrulation, epiboly progression is driven by the coordinated remodeling of the YSL microtubule network and F-actin cables. We recently described the implication of Nrz, an anti-apoptotic Bcl-2 homolog, in the control of the YSL cytoskeleton dynamics. Nrz knock-down induces premature actin-myosin ring formation leading to margin constriction, epiboly arrest and embryo lethality. At the molecular level, the Nrz protein controls the actin-myosin dynamics through IP3R-dependent calcium levels variation. Here, we discuss these novel findings and propose a model in which reversible phosphorylation of the Nrz/IP3R complex modulates the permeability of the IP3R calcium channel and thus may explain the Nrz-dependent control of IP3R opening required for proper epiboly completion.
authors: Université Lyon I; Centre de Recherche en Cancérologie de Lyon; Centre Léon Bérard; Lyon, France.
authors: Benjamin
authors: B
authors: Bonneau
authors: Nikolay
authors: N
authors: Popgeorgiev
authors: Julien
authors: J
authors: Prudent
authors: Germain
authors: G
authors: Gillet