title: In vivo activity of (8-hydroxymethylen)-trieicosanyl acetate against Trypanosoma cruzi during acute phase of the infection.
abstract: The antiprotozoal activity in vivo against Trypanosoma cruzi of (8-hydroxymethylen)-trieicosanyl acetate was evaluated in BALB/c mice during the acute phase of Chagas' disease (15 days after infection). Animals were treated during 15 days at doses of 16.8 and 33.6 µg/g, reduced parasitemia of 77.6 and 64.1% was observed respectively, in comparison with positive control mice (allopurinol 8.5 µg/g) which reduced only 29.7%. Also, amastigote nests in cardiac tissue were significant reduced in treated mice groups. The regression of effect induced after the suppression of the treatment with the compound was evaluated; animals were infected and simultaneously began the treatment with the compound during 20 days (16.8 and 33.6 µg/g). Mice were monitored after the end of the treatment for one more week. A good antitrypanosomal response was observed (66.1 and 68.9% less than untreated mice) during treatment, but 8 days after suspension of treatment, parasitemia level increased, reducing only 58.6 and 56.29 % respectively in treated animals compared with no treated.
authors: Laboratorio de Biologia Celular, CIR Dr. Hideyo Noguchi, Universidad Autonoma de Yucatán, Ave. Itzaes # 490 x 59, Centro, C P 97000, Merida Yucatan, Mexico. mjcoello@uady.mx
authors: Matilde
authors: M
authors: Jiménez-Coello
authors: Karla Yolanda
authors: KY
authors: Acosta-Viana
authors: Maria Salud
authors: MS
authors: Pérez G
authors: Eugenia del S
authors: Edel S
authors: Guzmán-Marín
mesh_terms: D000085:Acetates / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000284:Administration, Oral; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004305:Dose-Response Relationship, Drug; D015777:Eicosanoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007887:Fabaceae / Q000737:chemistry*; D006321:Heart / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D018512:Parasitemia / Q000188:drug therapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: C534089:(8-hydroxymethylen)trieicosanyl acetate; D000085:Acetates; D015777:Eicosanoids; D010936:Plant Extracts; D014344:Trypanocidal Agents