title: Liver transplantation as an ultimate step in the management of iatrogenic bile duct injury complicated by secondary biliary cirrhosis.
abstract: BACKGROUND
  This report summarizes a single center's experience with liver transplantation (LT) performed for secondary biliary cirrhosis resulting from iatrogenic bile duct injury (BDI) sustained during cholecystectomy.
  
  
  METHODS
  Secondary biliary cirrhosis was the indication for LT in 5 (1.7%) out of 300 LTs performed in our center between Feb 2002 and April 2011. We analyzed the medical history of the patients, perioperative course and outcome following LT.
  
  
  RESULTS
  The BDI was classified as Strasberg A in 1 case, B in two cases, and E in 2 cases. There was no hepatic arterial or portal vein injury in any patient. All of the surgical repairs prior to the development of cirrhosis were performed in general surgical units. The median time between BDI and listing the patient for LT was 11 years. The cadaveric whole-organ LT was done in all patients using the Piggy-Back technique. All patients are alive with a median follow-up of 53 months.
  
  
  CONCLUSIONS
  Liver transplantation in patients with secondary biliary cirrhosis appears to result from a series of inadequate multiple surgical repairs following BDI. The immediate referral of such patients to centers with bile duct surgery experience is crucial.
authors: Division of Hepatobiliary Surgery and Liver Transplantation, M. Curie Hospital, Szczecin, Poland. jerzy@lubikowski.pl
authors: Jerzy
authors: J
authors: Lubikowski
authors: Tomasz
authors: T
authors: Chmurowicz
authors: Mariola
authors: M
authors: Post
authors: Konrad
authors: K
authors: Jarosz
authors: Andrzej
authors: A
authors: Białek
authors: Piotr
authors: P
authors: Milkiewicz
authors: Maciej
authors: M
authors: Wójcicki
mesh_terms: D001652:Bile Ducts / Q000293:injuries* / Q000601:surgery; D002763:Cholecystectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome