title: Direct and highly regioselective and enantioselective allylation of β-diketones.
abstract: The enantioselective allylation of ketones is a problem of fundamental importance in asymmetric reaction design, especially given that only a very small number of methods can generate tertiary carbinols. Despite the vast amount of attention that synthetic chemists have given to this problem, success has generally been limited to just a few simple ketone types. A method for the selective allylation of functionally complex ketones would greatly increase the utility of ketone allylation methods in the chemical synthesis of important targets. Here we describe the operationally simple, direct, regioselective and enantioselective allylation of β-diketones. The strong tendency of β-diketones to act as nucleophilic species was overcome by using their enol form to provide the necessary Brønsted-acid activation. This reaction significantly expands the pool of enantiomerically enriched and functionally complex tertiary carbinols that may be easily accessed. It also overturns more than a century of received wisdom regarding the reactivity of β-diketones.
authors: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors: Wesley A
authors: WA
authors: Chalifoux
authors: Samuel K
authors: SK
authors: Reznik
authors: James L
authors: JL
authors: Leighton
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006851:Hydrochloric Acid / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D010422:Pentanones / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism; D000095702:Polyether Toxins
chemical_list: D006851:Hydrochloric Acid; D007659:Ketones; D018942:Macrolides; D000432:Methanol; D010422:Pentanones; D012821:Silanes; C083856:spongistatin 1; D000095702:Polyether Toxins; C008790:acetylacetone