title: Chromosomal alterations, prognostic factors, and targeted molecular therapies for malignant meningiomas.
abstract: Meningiomas are the second most common intracranial neoplasm in adults and originate from arachnoidal cap cells. Malignant meningiomas are resistant to conventional treatments such as surgery, chemotherapy, and radiotherapy. Unlike benign meningiomas, atypical and anaplastic tumors generally display more complex karyotypes associated with aggressive behavior. While these chromosomal anomalies are associated with greater malignancy in meningiomas, the specific genes involved remain unknown. Malignant meningiomas are characterized by increased tumor aggressiveness, rapid recurrence, local invasion, atypical histological appearance, and a high mitotic index. Potential prognostic factors include extent of resection, treatment with radiotherapy or stereotactic radiosurgery, Ki-67/MIB-1 labeling index, p53 overexpression, percentage of tumor cells in the S-phase, telomerase activity, and numerous genetic expression profiles. A greater understanding of prognostic factors and molecular markers involved in critical signaling pathways may aid in the identification of novel therapeutic targets. As such, further studies are needed to establish reliable prognostic factors and develop more effective treatments for malignant meningiomas.
authors: UCLA Department of Neurosurgery, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1761, USA.
authors: Andrew
authors: A
authors: Yew
authors: Andy
authors: A
authors: Trang
authors: Daniel T
authors: DT
authors: Nagasawa
authors: Marko
authors: M
authors: Spasic
authors: Winward
authors: W
authors: Choy
authors: Heather M
authors: HM
authors: Garcia
authors: Isaac
authors: I
authors: Yang
mesh_terms: D002869:Chromosome Aberrations; D006801:Humans; D016898:Interferon-alpha / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008579:Meningioma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D058990:Molecular Targeted Therapy / Q000379:methods*; D011379:Prognosis; D011979:Receptors, Pituitary Hormone / Q000378:metabolism
chemical_list: D016898:Interferon-alpha; D019394:Ki-67 Antigen; D011979:Receptors, Pituitary Hormone