title: Heterologous interactions between NS1 proteins from different influenza A virus subtypes/strains.
abstract: Non-structural protein 1 (NS1) of the influenza virus plays a crucial role in modulating the host immune response and facilitating virus replication. The formation of a homodimer or an oligomer is necessary for NS1 to exert its function efficiently. In the present study, the NS1 protein from the A/Shantou/602/06(H3N2) virus (herein abbreviated as NS32) was found to interact with NS1 from A/Shantou/169/06(H1N1), A/Chicken/Guangdong/1/05(H5N1) and A/Quail/Hong Kong/G1/97(H9N2) (abbreviated as NS11, NS51 and NS92, respectively) viruses, although NS32 shares 17.4%-20.9% sequence diversity with NS11, NS51 and NS92. This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/ strains may be a common event during co-infection.
authors: Department of Microbiology and Immunology, Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515041, China.
authors: Weizhong
authors: W
authors: Li
authors: Heng
authors: H
authors: Zhang
authors: Gefei
authors: G
authors: Wang
authors: Chi
authors: C
authors: Zhang
authors: Xiangxing
authors: X
authors: Zeng
authors: Hui
authors: H
authors: Liu
authors: Xiaoxuan
authors: X
authors: Chen
authors: Yanxuan
authors: Y
authors: Xu
authors: Kangsheng
authors: K
authors: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D002645:Chickens; D014644:Genetic Variation; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D015151:Immunoblotting; D047468:Immunoprecipitation; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000378:metabolism*; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000378:metabolism*; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000378:metabolism*; D053127:Influenza A Virus, H9N2 Subtype / Q000235:genetics / Q000378:metabolism*; D005585:Influenza in Birds / Q000821:virology; D007251:Influenza, Human / Q000821:virology; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D011485:Protein Binding; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D020798:Two-Hybrid System Techniques; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D049452:Green Fluorescent Proteins