title: Mitochondrial roles and cytoprotection in chronic liver injury.
abstract: The liver is one of the richest organs in terms of number and density of mitochondria. Most chronic liver diseases are associated with the accumulation of damaged mitochondria. Hepatic mitochondria have unique features compared to other organs' mitochondria, since they are the hub that integrates hepatic metabolism of carbohydrates, lipids and proteins. Mitochondria are also essential in hepatocyte survival as mediator of apoptosis and necrosis. Hepatocytes have developed different mechanisms to keep mitochondrial integrity or to prevent the effects of mitochondrial lesions, in particular regulating organelle biogenesis and degradation. In this paper, we will focus on the role of mitochondria in liver physiology, such as hepatic metabolism, reactive oxygen species homeostasis and cell survival. We will also focus on chronic liver pathologies, especially those linked to alcohol, virus, drugs or metabolic syndrome and we will discuss how mitochondria could provide a promising therapeutic target in these contexts.
authors: AP-HP, Hôpital Paul Brousse, Service de Biochimie et Biologie Moléculaire, 14 Avenue Paul Vaillant Couturier, 94804 Villejuif Cedex, France.
authors: Davide
authors: D
authors: Degli Esposti
authors: Jocelyne
authors: J
authors: Hamelin
authors: Nelly
authors: N
authors: Bosselut
authors: Raphaël
authors: R
authors: Saffroy
authors: Mylène
authors: M
authors: Sebagh
authors: Alban
authors: A
authors: Pommier
authors: Cécile
authors: C
authors: Martel
authors: Antoinette
authors: A
authors: Lemoine