title: [Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men].
abstract: OBJECTIVE
  To investigate the association of prostate cancer (PCa) with PDLIM5 (rs17021918, T), SLC22A3 (rs9364554, C) and NKX3-1 (rs1512268, A) in Chinese men.
  
  
  METHODS
  We included 124 PCa patients and 138 normal controls in this study, compared the alleles and genotypes of PDLIM5 (rs17021918, T) , SLC22A3 (rs9364554, C) and NKX3-1 (rs1512268, A) of the two groups, and explored the association of each of the genes with the age, body mass index (BMI), Gleason score, PSA level and tumor stage of the patients. We analyzed the gene-gene interaction using the multifactor dimensionality reduction method (MDR).
  
  
  RESULTS
  There were no statistically significant differences in the frequency distribution of the risk alleles and genotypes of PDLIM5, SLC22A3 and NKX3-1 between the case and control groups (P > 0.05), nor were the three gene loci significantly associated with the age, Gleason score, PSA level and pathological grade of the PCa patients (CP < 0.05). MDR analysis showed no interaction between PDLIM5 and NKX3-1, but tree-diagram analysis revealed a possible synergistic action of the two polymorphism loci.
  
  
  CONCLUSIONS
  PCa might not be associated with PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) in Chinese men. However, PDLIM5 and NKX3-1 might have a synergistic action on the risk PCa.
authors: Key Laboratory of the Chinese Ministry of Health for Geriatric Medicine/Beijing Institute of Geriatric Medicine, Beijing Hospital, Beijing 100730, China. hui-937@163.com
authors: Juan
authors: J
authors: Hui
authors: Jian-Ye
authors: JY
authors: Wang
authors: Xiao-Hong
authors: XH
authors: Shi
authors: Yao-Guang
authors: YG
authors: Zhang
authors: Ming
authors: M
authors: Liu
authors: Xin
authors: X
authors: Wang
authors: Na-Na
authors: NN
authors: Wang
authors: Xin
authors: X
authors: Chen
authors: Si-Ying
authors: SY
authors: Liang
authors: Dong
authors: D
authors: Wei
authors: Fan
authors: F
authors: Zhao
authors: Yu-Hong
authors: YH
authors: Zhang
authors: Ze
authors: Z
authors: Yang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*; D000099254:Organic Cation Transporter 3
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018398:Homeodomain Proteins; D060588:LIM Domain Proteins; D027701:Organic Cation Transport Proteins; D014157:Transcription Factors; D000099254:Organic Cation Transporter 3; C491178:NKX3-1 protein, human; C512485:PDLIM5 protein, human