title: On the importance of modelling organ geometry and boundary conditions for predicting three-dimensional prostate deformation.
abstract: The use of an ultrasound probe or a needle guide during biopsy deforms both the rectal wall and the prostate, resulting in lesion motion. An accurate patient-specific finite element (FE)-based biomechanical model can be used to predict prostate deformations. In this study, an FE model of a prostate phantom is developed using magnetic resonance images, while soft-tissue elasticity is estimated in vivo using an ultrasound-based acoustic radiation force impulse imaging technique. This study confirms that three-dimensional FE-predicted prostate deformation is predominantly dependent on accurate modelling of prostate geometry and boundary conditions. Upon application of various compressive displacements, our results show that a linear elastic FE model can accurately predict prostate deformations. The maximum global error between FE-predicted simulations and experimental results is 0.76 mm. Moreover, the effect of including the urethra, puboprostatic ligament and urinary bladder on prostate deformations is investigated by a sensitivity study.
authors: a MIRA - Institute for Biomedical Technology and Technical Medicine, University of Twente , Enschede , The Netherlands.
authors: Alex
authors: A
authors: Jahya
authors: Martijn G
authors: MG
authors: Schouten
authors: Jurgen J
authors: JJ
authors: Fütterer
authors: Sarthak
authors: S
authors: Misra
mesh_terms: D001696:Biomechanical Phenomena; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008953:Models, Anatomic; D009038:Motion; D019047:Phantoms, Imaging; D011467:Prostate / Q000033:anatomy & histology* / Q000000981:diagnostic imaging