title: Effects of a moderate physical training on the leptin synthesis by adipose tissue of adult rats submitted to a perinatal low-protein diet.
abstract: The aim of the study was to verify if moderate physical training affects leptin content in visceral and subcutaneous adipose tissue of adult rats subjected to a low-protein diet during the perinatal period. Male Wistar rats were divided into 2 groups according to their mother's diet during gestation and lactation: control (17% casein, C, n=12) and low-protein (8% casein, LP, n=12). On postnatal day 60, half of each group was submitted to moderate physical training (8 wks, 5 d · wk - 1, 60 min · d - 1, at 70% of VO2max, T) or not. After the physical training period, visceral and subcutaneous adipose tissues were removed. Leptin content was evaluated by western blotting. Starting from the fifth week on, T pups showed a reduction in the body weight. Similarly, LP+T offspring showed a lower body weight starting from the sixth week on. Western blotting analysis showed that leptin content in the visceral tissue was higher in the LP rats (p<0.01) and it was reversed in LP+T. No difference was found in the subcutaneous tissue. Moderate physical training attenuated the effects of a perinatal low-protein diet on the leptin content in visceral adipose tissue in adult offspring.
authors: Department of Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil. iracemamelo@hotmail.com
authors: I H P
authors: IH
authors: de Mélo Montenegro
authors: L
authors: L
authors: Moita
authors: F K W
authors: FK
authors: Dos Reis
authors: E
authors: E
authors: de Oliveira
authors: P C
authors: PC
authors: Lisboa
authors: E G
authors: EG
authors: de Moura
authors: R
authors: R
authors: Manhães-de-Castro
authors: C G
authors: CG
authors: Leandro
mesh_terms: D000818:Animals; D018753:Diet, Protein-Restricted; D015444:Exercise; D005260:Female; D047109:Fetal Development; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism; D020738:Leptin / Q000096:biosynthesis*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D018743:Perinatal Care; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020738:Leptin