title: An analysis of long-term survival and renal function in simultaneous pancreas and kidney transplantation from the OPTN/UNOS registry.
abstract: SPK was the most frequent method of pancreas transplantation in the US, accounting for 72% of all pancreas transplantations. The number of annual SPK recipients has been consistent over the past 10 years; however, there was an increase in the proportion of recipients with type 2 diabetes. The mean age of recipients has been increasing year by year, whereas the mean age of donors has been decreasing. In contrast to observations for diabetic patients without transplantation, the incidence of cardiovascular death in type 2 diabetic recipients was not higher than type 1 diabetic recipients, whereas infectious death was more common in type 2 diabetic recipients. CKD staging at discharge is an important predictor, not only for kidney graft outcome, but also for pancreas graft outcome. Pancreas graft survival in the CKD stage 3 group, which was the main group of SPK, was similar to those in higher renal function groups, whereas their kidney graft survival rates were different.
authors: Terasaki Foundation Laboratory, Los Angeles, CA, USA. jhoshinoind@gmail.com
authors: Junichi
authors: J
authors: Hoshino
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality; D002423:Cause of Death; D016009:Chi-Square Distribution; D003922:Diabetes Mellitus, Type 1 / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality / Q000639:trends; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000401:mortality / Q000639:trends; D016016:Proportional Hazards Models; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome; D014481:United States; D014850:Waiting Lists; D055815:Young Adult