title: [Epidemiological profile and sensitivity pattern of isolates causing invasive fungal infection vs. colonizing isolates in non-neutropenic critically ill patients].
abstract: BACKGROUND
  Patients admitted to critical care units can be infected with a large number of fungal isolates that are occasionally responsible for invasive fungal infections (IFI).
  
  
  OBJECTIVE
  To describe the epidemiological profile and antifungal susceptibility patterns of fungal isolates in our unit, and to identify key risk factors associated with the development of IFI.
  
  
  METHODS
  A descriptive cohort and retrospective study with patients admitted to a polyvalent Critical Care Unit of a university hospital was carried out. The isolation of at least one fungal species in a culture of biological samples, over a period of 48 months was considered.
  
  
  RESULTS
  Twenty patients out of 232 developed IFI. Patients in the IFI group had a higher mortality and higher Candida score value 48 h prior to clinical diagnosis. Risk factors associated with the development of IFI were chronic obstructive pulmonary disease, gastrointestinal surgery, total parenteral nutrition, and prolonged systemic corticosteroid therapy. The predominant fungal species in both groups was Candida albicans, with global resistance to fluconazole and itraconazole of 1.94%.
  
  
  CONCLUSIONS
  We found a low incidence of species of Candida non-C. albicans in our unit. The rate of resistance to azoles in C. albicans was similar to that of larger series. Gastrointestinal surgery, COPD, prolonged treatment with corticosteroids, and parenteral nutrition administration are risk factors associated with the development of IFI.
authors: Servicio de Medicina Intensiva, Hospital General Universitario de Alicante, Alicante, España. serrano_ric@gva.es
authors: Ricardo
authors: R
authors: Serrano
authors: Adelina
authors: A
authors: Gimeno
authors: Lidia
authors: L
authors: Plumed
authors: Javier
authors: J
authors: Pemán
authors: Bernabé
authors: B
authors: Alvarez
authors: Joaquín
authors: J
authors: Plazas
authors: Juan
authors: J
authors: Caturla
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000453:epidemiology / Q000382:microbiology; D002175:Candida / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D058365:Candidiasis, Invasive / Q000453:epidemiology* / Q000382:microbiology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000382:microbiology; D015897:Comorbidity; D016638:Critical Illness; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D025141:Drug Resistance, Fungal; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology; D017052:Hospital Mortality; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000706:statistics & numerical data; D010407:Penicillium / Q000302:isolation & purification; D011183:Postoperative Complications / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D007166:Immunosuppressive Agents