title: Vaccine potential of an attenuated Pasteurella multocida that expresses only the N-terminal truncated fragment of P. multocida toxin in pigs.
abstract: Previously we described the development of an attenuated Pasteurella multocida mutant that expresses only the N-terminal truncated fragment of P. multocida toxin (N-PMT) and its protective effects in a mouse model. This paper details our evaluation of the vaccine potential of this mutant strain in pigs. Pigs vaccinated with the mutant showed significantly higher rates of antibody induction and lower nasal conchal (turbinate) scores for atrophic rhinitis than controls, which suggests that this mutant strain may be a good candidate for a live attenuated vaccine.
authors: College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors: Taejung
authors: T
authors: Kim
authors: Changho
authors: C
authors: Son
authors: Jaeil
authors: J
authors: Lee
authors: Kwanghyun
authors: K
authors: Kim
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology / Q000494:pharmacology*; D009154:Mutation / Q000276:immunology; D010326:Pasteurella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; C062258:Pasteurella multocida toxin; D010446:Peptide Fragments