title: Enamino-oxindole HIV protease inhibitors.
abstract: We have designed and synthesized a series of HIV protease inhibitors (PIs) with enamino-oxindole substituents optimized to interact with the S2' subsite of the HIV protease binding pocket. Several of these inhibitors have sub-nanomolar K(i) and antiviral IC(50) in the low nM range against WT HIV and against a panel of multi-drug resistant (MDR) strains.
authors: Sequoia Pharmaceuticals, Inc., Gaithersburg, MD 10878, USA. eissenst@comcast.net
authors: Michael
authors: M
authors: Eissenstat
authors: Tanya
authors: T
authors: Guerassina
authors: Sergei
authors: S
authors: Gulnik
authors: Elena
authors: E
authors: Afonina
authors: Abelardo M
authors: AM
authors: Silva
authors: Douglas
authors: D
authors: Ludtke
authors: Hiroko
authors: H
authors: Yokoe
authors: Betty
authors: B
authors: Yu
authors: John
authors: J
authors: Erickson
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D000069454:Darunavir; D024882:Drug Resistance, Viral / Q000187:drug effects; D016333:HIV Protease / Q000737:chemistry* / Q000378:metabolism; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000078183:Oxindoles; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D017320:HIV Protease Inhibitors; D007211:Indoles; D000078183:Oxindoles; D013449:Sulfonamides; C022960:2-oxindole; D016333:HIV Protease; D000069454:Darunavir