title: Isthmin inhibits glioma growth through antiangiogenesis in vivo.
abstract: Among glioma treatment strategies, antiangiogenesis emerges as a meaningful and feasible treatment approach for inducing long-term survival. Isthmin is a gene highly expressed in the isthmus of the midbrain-hindbrain organizer in Xenopus, and has recently been identified as a novel angiogenesis inhibitor. However, the potential of isthmin on the glioma angiogenesis has not been well studied. In the present study, we demonstrated that the recombinant adenovirus isthmin (Ad-isthmin) could inhibit VEGF-stimulated endothelial cell proliferation and induce apoptosis through a caspase-dependent pathway. In addition, Ad-isthmin significantly suppressed glioma growth through antiangiogenesis without apparent side effects. Taken together, our results demonstrated that isthmin could act as a novel angiogenesis inhibitor and might be utilized in the glioma antiangiogenesis therapy.
authors: Department of Neurosurgery, The 476th Hospital of Fuzhou General Hospital, Fuzhou, 350025, Fujian, China.
authors: Bangqing
authors: B
authors: Yuan
authors: Ronghua
authors: R
authors: Xian
authors: Jianfang
authors: J
authors: Ma
authors: Yujian
authors: Y
authors: Chen
authors: Chuangan
authors: C
authors: Lin
authors: Yaoming
authors: Y
authors: Song
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005434:Flow Cytometry; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008819:Mice, Nude; D055806:Microvessels / Q000473:pathology; D011506:Proteins / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014161:Transduction, Genetic; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C571340:isthmin protein, mouse