title: Prevention or acceleration of type 1 diabetes by viruses.
abstract: Type 1 diabetes is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic β-cell destruction, little is known about the events that trigger the autoimmune process. Recent epidemiological and experimental data suggest that environmental factors are involved in this process. In this review, we discuss the role of viruses as an environmental factor on the development of type 1 diabetes, and the immune mechanisms by which they can trigger or protect against this pathology.
authors: Université Paris Descartes, [corrected] Hôpital Saint Vincent de Paul/Cochin, Bâtiment [corrected] Petit, 82 Avenue Denfert-Rochereau 75014, Paris, France. liana.ghazarian@inserm.fr
authors: Liana
authors: L
authors: Ghazarian
authors: Julien
authors: J
authors: Diana
authors: Yannick
authors: Y
authors: Simoni
authors: Lucie
authors: L
authors: Beaudoin
authors: Agnès
authors: A
authors: Lehuen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D004770:Enterovirus / Q000472:pathogenicity*; D004769:Enterovirus Infections / Q000276:immunology* / Q000821:virology*; D006801:Humans; D061148:Hygiene Hypothesis; D050417:Insulin-Secreting Cells / Q000276:immunology* / Q000821:virology; D051379:Mice; D012307:Risk Factors; D012959:Socioeconomic Factors; D013601:T-Lymphocytes / Q000276:immunology