title: Biological significance of HORMA domain containing protein 1 (HORMAD1) in epithelial ovarian carcinoma.
abstract: The present study was undertaken to determine the expression and biological significance of HORMAD1 in human epithelial ovarian carcinoma. We found that a substantial proportion of human epithelial ovarian cancers expressed HORMAD1. In vitro, HORMAD1 siRNA enhanced docetaxel induced apoptosis and substantially reduced the invasive and migratory potential of ovarian cancer cells (2774). In vivo, HORMAD1 siRNA-DOPC treatment resulted in reduced tumor weight, which was further enhanced in combination with cisplatin. HORMAD1 gene silencing resulted in significantly reduced VEGF protein levels and microvessel density compared to controls. Our data suggest that HORMAD1 may be an important therapeutic target.
authors: Department of Gynecologic Oncology, U.T.M.D. Anderson Cancer Center, Houston, TX 77030, United States.
authors: Mian M K
authors: MM
authors: Shahzad
authors: Yong-Hyun
authors: YH
authors: Shin
authors: Koji
authors: K
authors: Matsuo
authors: Chunhua
authors: C
authors: Lu
authors: Masato
authors: M
authors: Nishimura
authors: De-Yo
authors: DY
authors: Shen
authors: Yu
authors: Y
authors: Kang
authors: Wei
authors: W
authors: Hu
authors: Edna M
authors: EM
authors: Mora
authors: Cristian
authors: C
authors: Rodriguez-Aguayo
authors: Arvinder
authors: A
authors: Kapur
authors: Justin
authors: J
authors: Bottsford-Miller
authors: Gabriel
authors: G
authors: Lopez-Berestein
authors: Aleksandar
authors: A
authors: Rajkovic
authors: Anil K
authors: AK
authors: Sood
mesh_terms: D000818:Animals; D000077216:Carcinoma, Ovarian Epithelial; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051379:Mice; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D012333:RNA, Messenger / Q000032:analysis; D034741:RNA, Small Interfering / Q000235:genetics; D059016:Tumor Microenvironment; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000235:genetics / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; C576915:HORMAD1 protein, human; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D042461:Vascular Endothelial Growth Factor A