title: Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting.
abstract: BACKGROUND
  Leg swelling is a modern-day affliction of sedentary working women. The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.
  
  
  RESULTS
  Single intake trials and 14 day intake trials were held in a double-blind, placebo-controlled, crossover clinical study. A prolonged sedentary position was maintained for 6 h after GSE or placebo administration. Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.
  
  
  CONCLUSIONS
  The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.
authors: Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba, Japan. asano@mail.kikkoman.co.jp
authors: Atsushi
authors: A
authors: Sano
authors: Shoichi
authors: S
authors: Tokutake
authors: Akihiko
authors: A
authors: Seo
mesh_terms: D000328:Adult; D001823:Body Composition; D001834:Body Water / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004487:Edema / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D056604:Grape Seed Extract / Q000008:administration & dosage*; D006801:Humans; D007866:Leg; D010919:Placebos; D011187:Posture; D044945:Proanthocyanidins / Q000008:administration & dosage*; D027843:Vitis
chemical_list: D056604:Grape Seed Extract; C511402:Grape Seed Proanthocyanidins; D010919:Placebos; D044945:Proanthocyanidins