title: Isolactarane and sterpurane sesquiterpenoids from the basidiomycete Phlebia uda.
abstract: Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete Phlebia uda. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus Fusarium graminearum at 10 and 5 μg/mL, respectively, and were active against Jurkat cells with IC(50) values of 101 and 42 μM, respectively.
authors: Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Strasse 56, 67663 Kaiserslautern, Germany.
authors: Anja
authors: A
authors: Schüffler
authors: Beate
authors: B
authors: Wollinsky
authors: Timm
authors: T
authors: Anke
authors: Johannes C
authors: JC
authors: Liermann
authors: Till
authors: T
authors: Opatz
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes