title: Pluronic lecithin organogel as a topical drug delivery system.
abstract: The objective of this study was to formulate and evaluate the pluronic lecithin organogel containing flurbiprofen for topical application. Different formulations of pluronic lecithin organogels were prepared by using pluronic F127, lecithin, flurbiprofen, isopropyl palmitate, water, sorbic acid, and potassium sorbate. To study the in vitro potential of these formulations, permeation studies were performed with Keshary-Chien diffusion cells. The results of the in vitro permeation studies found that release of flurbiprofen from dialysis membrane-70 was more than excised dorsal rat skin. Gelation temperature study was carried out to determine the temperature where sol-gel transformation takes place. The viscosities of different formulations were determined by using Brookfield Viscometer at 25°C, the viscosity of formulations increases as the lecithin concentration increases. Also the formulations were tested for appearance and feel psychorheologically, pH, and drug content. Interactions between the components of the gel have been investigated by differential scanning calorimetry and X-ray powder diffractometry. The optimized formulation subjected to differential scanning calorimetry shows no drug-polymer interaction. To investigate the in vivo performance of the formulations, a carrageenan-induced rat paw edema model and skin irritation study was used. The stability studies and freeze-thaw thermal cyclic test were carried out, showing no phase separation of gel, and representing gel stability. Statistical analysis of the data of animal study (anti-inflammatory activity) was done by using one way analysis of variance (ANOVA) followed by Dunnett's test. The formulation shows a statistically significant anti-inflammatory activity and is non-irritant to skin.
authors: Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.
authors: Mohit
authors: M
authors: Pandey
authors: Veena
authors: V
authors: Belgamwar
authors: Surendra
authors: S
authors: Gattani
authors: Sanjay
authors: S
authors: Surana
authors: Avinash
authors: A
authors: Tekade
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004355:Drug Stability; D004487:Edema / Q000188:drug therapy; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005782:Gels; D006168:Guinea Pigs; D054709:Lecithins / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D010539:Permeability; D020442:Poloxamer / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D023422:Skin Irritancy Tests; D013499:Surface Properties; D014783:Viscosity; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; D054709:Lecithins; D020442:Poloxamer; D005480:Flurbiprofen