title: Bile salts predict liver regeneration in rabbit model of portal vein embolization.
abstract: BACKGROUND
  Portal vein embolization (PVE) is employed to increase future remnant liver (FRL) volume through induction of hepatocellular regeneration in the nonembolized liver lobe. The regenerative response is commonly determined by CT volumetry after PVE. The aim of the study was to examine plasma bile salts and triglycerides in the prediction of the regenerative response following PVE.
  
  
  METHODS
  PVE of the cranial liver lobe was performed in 15 rabbits, divided into three groups: NaCl (control), gelatin sponge (short-term occlusion), and polyvinyl alcohol particles with coils (PVAc, long-term occlusion). In all rabbits CT volumetry and blood sampling were performed prior to PVE and on days 3 and 7. Plasma bile salts and triglycerides were correlated with volume increase of the nonembolized liver lobe.
  
  
  RESULTS
  After 3 and 7 d, respectively, FRL volume was increased in both embolized groups, with the largest hypertrophy response observed in the PVAc group. Plasma bile salt levels were increased after PVE, especially in the PVAc group at day 3 (P < 0.01 compared to gelatin sponge). Plasma bile salts at day 3 predicted FRL volume increase at day 7 showing a positive correlation of 0.811 (P < 0.001). Levels of triglycerides were not significantly altered in either of the PVE procedures.
  
  
  CONCLUSIONS
  Plasma bile salt levels early after PVE strongly correlated with the regenerative response in a rabbit model of PVE, showing more pronounced elevation with larger volume increase of the nonembolized lobe. Therefore, plasma bile salts, but not triglycerides, can be used in the prediction of the regenerative response after PVE.
authors: Department of Surgery (Surgical Laboratory), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Lisette T
authors: LT
authors: Hoekstra
authors: Max
authors: M
authors: Rietkerk
authors: Krijn P
authors: KP
authors: van Lienden
authors: Jacomina W
authors: JW
authors: van den Esschert
authors: Frank G
authors: FG
authors: Schaap
authors: Thomas M
authors: TM
authors: van Gulik
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood*; D004621:Embolization, Therapeutic; D005260:Female; D008115:Liver Regeneration / Q000502:physiology*; D009929:Organ Size; D011169:Portal Vein; D011817:Rabbits; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D014280:Triglycerides