title: The effect of intravenous cyclosporine on rates of colonic surgery in hospitalized patients with severe Crohn's colitis.
abstract: BACKGROUND
  The role of intravenous (IV) cyclosporine in severe Crohn's colitis (CC) is poorly studied.
  
  
  OBJECTIVE
  Our primary aim was to determine the in-hospital colonic resection rate in patients with severe CC who received IV cyclosporine, and the potential predictors of resection among these patients.
  
  
  METHODS
  An inpatient pharmacy query of all patients who received IV cyclosporine at Mount Sinai Medical Center for 12.5 years after January 1, 1996 was reviewed. Patients with CC or indeterminate colitis favoring Crohn's were included and their medical records were reviewed. Subsequent need for colonic surgery was assessed. A Kaplan-Meier plot with log-rank testing was performed to determine the rate of colonic surgery avoidance. Forward stepwise logistic regression was performed to determine independent predictors of surgery.
  
  
  RESULTS
  Forty-eight patients met our inclusion criteria. Prior thiopurine and anti-tumor necrosis factor (anti-TNF) use was 85% and 69%, respectively. The median follow-up time was 12 months (range, 1 to 60 mo). 12.5% of patients required colonic resection during their admission for IV cyclosporine. Anti-TNF use in the 4 weeks preceding IV cyclosporine was the only predictor of surgery in this setting (P=0.05). The cumulative colonic surgery avoidance rate was 72±13% at 6 months and 59±15% at 12 months.
  
  
  CONCLUSIONS
  The use of IV cyclosporine resulted in a low rate of in-hospitalization colonic surgery among CC patients with severe disease, the majority of whom previously failed anti-TNFs and thiopurines.
authors: Department of Medicine, The Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, Division of Gastroenterology, The Johns Hopkins University Medical Institutions, Baltimore, MD 21287, USA. mlazare1@jhmi.edu
authors: Mark
authors: M
authors: Lazarev
authors: Daniel H
authors: DH
authors: Present
authors: Simon
authors: S
authors: Lichtiger
authors: Asher
authors: A
authors: Kornbluth
authors: James
authors: J
authors: Marion
authors: Mark
authors: M
authors: Chapman
authors: Thomas A
authors: TA
authors: Ullman
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D003082:Colectomy / Q000379:methods / Q000706:statistics & numerical data*; D003092:Colitis / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D003106:Colon / Q000601:surgery; D003424:Crohn Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005765:Gastrointestinal Agents; D016572:Cyclosporine