title: Colloid update.
abstract: This update aims to provide an evidence based review of natural and synthetic colloids with a special emphasis on the various generations of the synthetic colloid hydroxyethyl starch. The effect of 1(st), 2(nd) and 3(rd) generation hetastarches on bleeding, coagulopathy, acute kidney injury and mortality will be discussed. The results of randomised controlled trials addressing morbidity and mortality outcomes of colloid versus crystalloid resuscitation in critically ill patients will be described. In addition, the rationale and evidence behind early goal directed fluid therapy (EGDFT) including a practical approach to assessment of dynamic measures of fluid responsiveness will be presented.
authors: PACU and SDS, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA. ARGALIM@ccf.org
authors: Maged Y
authors: MY
authors: Argalious
mesh_terms: D000818:Animals; D003102:Colloids; D003422:Critical Care; D016638:Critical Illness; D000077324:Crystalloid Solutions; D005440:Fluid Therapy / Q000009:adverse effects / Q000401:mortality; D006439:Hemodynamics; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects / Q000031:analogs & derivatives / Q000145:classification / Q000627:therapeutic use*; D007552:Isotonic Solutions / Q000627:therapeutic use; D019990:Perioperative Care; D010952:Plasma Substitutes / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012769:Shock / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes