title: New insights into ER stress-induced insulin resistance.
abstract: Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the last decade, endoplasmic reticulum (ER) stress has emerged as a new player in this field and a considerable number of recent studies have pointed out its role in the onset of insulin resistance (IR). ER stress appears to act directly as a negative modulator of the insulin signaling pathway but also indirectly by promoting lipid accumulation. This review aims to summarize and decipher the abundant new literature concerning the emerging and multifaceted involvement of ER stress in the development of metabolic dysfunctions in insulin target tissues.
authors: Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers, Unité Mixte de Recherche en Santé (UMR-S) 872, Paris, F-75006 France.
authors: Mélissa
authors: M
authors: Flamment
authors: Eric
authors: E
authors: Hajduch
authors: Pascal
authors: P
authors: Ferré
authors: Fabienne
authors: F
authors: Foufelle
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology; D009765:Obesity; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: D014157:Transcription Factors