title: Dumping symptoms and incidence of hypoglycaemia after provocation test at 6 and 12 months after laparoscopic sleeve gastrectomy.
abstract: BACKGROUND
  A previous study has demonstrated that symptoms suggestive of dumping syndrome appear after a provocation test early after laparoscopic sleeve gastrectomy (LSG) in 45 % of patients, and these are mainly related to early dumping. The aim of this study is to evaluate the evolution of dumping symptoms during the first postoperative year.
  
  
  METHODS
  Twenty-five non-diabetic morbidly obese patients (6 male, 19 female) were evaluated with an oral glucose tolerance test (OGTT) preoperatively, at 6 weeks and at 6 months postoperatively. In addition, 12 of them repeated the OGTT at 12 months after LSG. Sigstad score was used to separate dumpers from non-dumpers and Arts' questionnaire to differentiate between early and late dumping. Insulin and glucose levels were also measured.
  
  
  RESULTS
  Sigstad score remained significantly elevated at 6 and 12 months postoperatively compared to preoperative values. Symptoms suggestive of dumping syndrome were recorded in 40 % of patients at 6 months and in 33 % at 12 months postoperatively. Arts' questionnaire demonstrated that early dumping score remained higher compared to baseline at 6 and 12 months postoperatively. Late dumping scores increased gradually during the time and that difference was statistically significant at 12 months after LSG. Hypoglycaemia occurred at 33 % of patients both at 6 and 12 months postoperatively.
  
  
  CONCLUSIONS
  Symptoms suggestive of dumping syndrome after provocation still exist at 6 and 12 months in a significant proportion of patients after LSG and include both early and late dumping. These findings are consistent with the high incidence of hypoglycaemia after OGTT at 6 and 12 months after LSG.
authors: Department of Endocrinology, University Hospital of Larissa, Larissa, Greece.
authors: Dimitris
authors: D
authors: Papamargaritis
authors: George
authors: G
authors: Koukoulis
authors: Eleni
authors: E
authors: Sioka
authors: Eleni
authors: E
authors: Zachari
authors: Alexandra
authors: A
authors: Bargiota
authors: Dimitris
authors: D
authors: Zacharoulis
authors: George
authors: G
authors: Tzovaras
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004377:Dumping Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D015391:Gastroplasty / Q000009:adverse effects* / Q000379:methods; D005951:Glucose Tolerance Test; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D010535:Laparoscopy; D008297:Male; D009767:Obesity, Morbid / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome