title: Copper(I)-catalyzed azide-alkyne cycloadditions in microflow: catalyst activity, high-T operation, and an integrated continuous copper scavenging unit.
abstract: AVOIDING THE COPPERS: A continuous-flow synthesis for the Cu(I) -catalyzed azide-alkyne cycloaddition reaction using [Cu(phenanthroline)(PPh₃)₂]NO₃ as a homogeneous catalyst is developed (up to 92 % isolated yield). Elevated temperatures allow achieving full conversions and using lower catalyst loadings. Residual copper in the triazole compound is efficiently removed via an inline extraction process, employing aqueous EDTA as a copper scavenger.
authors: Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, The Netherlands.
authors: Alvaro Carlos
authors: AC
authors: Varas
authors: Timothy
authors: T
authors: Noël
authors: Qi
authors: Q
authors: Wang
authors: Volker
authors: V
authors: Hessel
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D013696:Temperature
chemical_list: D000480:Alkynes; D001386:Azides; D003300:Copper