title: Microbial production of itaconic acid: developing a stable platform for high product concentrations.
abstract: Biotechnologically produced itaconic acid (IA) is a promising organic acid with a wide range of applications and the potential to open up new application fields in the area of polymer chemistry, pharmacy, and agriculture. In this study, a systematic process optimization was performed with an own isolated strain of Aspergillus terreus and transferred from a 250-mL to a 15-L scale. An IA concentration of 86.2 g/L was achieved within 7 days with an overall productivity of 0.51 g/(L h), a maximum productivity of 1.2 g/(L h), and a yield of 86 mol%. A cultivation of other well-known A. terreus strains with the developed process showed no significant differences. Based on this, a process is developed providing a high final IA concentration independent of the used strain combined with high reproducibility.
authors: vTI-Institute of Agricultural Technology and Biosystems Engineering, Bundesallee 50, 38116, Braunschweig, Germany. anja.kuenz@vti.bund.de
authors: Anja
authors: A
authors: Kuenz
authors: Yvonne
authors: Y
authors: Gallenmüller
authors: Thomas
authors: T
authors: Willke
authors: Klaus-Dieter
authors: KD
authors: Vorlop
mesh_terms: D001230:Aspergillus / Q000254:growth & development / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D013386:Succinates / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013386:Succinates; C005229:itaconic acid