title: Fumonisin B1 and the kidney: modes of action for renal tumor formation by fumonisin B1 in rodents.
abstract: The mycotoxin fumonisin B1 (FB1) is an important contaminant of maize and maize-based products. In rodent toxicity studies, FB1 was shown to be hepato- and nephrotoxic, and to induce renal tumors in rats when administered via the diet. Of particular note are the aggressive growth characteristics of FB1-induced tumors with a high potential to metastasize. While genotoxicity does not appear to contribute to FB1 carcinogenicity, it is well established that FB1-mediated disruption of sphingolipid metabolism plays a key role in FB1 toxicity. This review provides an overview on human dietary exposure to FB1, FB1 toxicity and carcinogenicity, and potential mechanisms involved in FB1-mediated tumor formation, with a particular focus on cellular functions of sphingolipids and biological consequences of FB1-mediated perturbation of sphingolipid metabolism.
authors: Department of Toxicology, University of Würzburg, Germany.
authors: Stephanie
authors: S
authors: Müller
authors: Wolfgang
authors: W
authors: Dekant
authors: Angela
authors: A
authors: Mally
mesh_terms: D000818:Animals; D005506:Food Contamination; D037341:Fumonisins / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced*; D051381:Rats
chemical_list: D037341:Fumonisins; C056933:fumonisin B1