title: Multiple eruptive squamous cell carcinoma in a patient with chronic plaque psoriasis on adalimumab.
abstract: A 67-year-old man with chronic plaque psoriasis previously treated with psoralen plus PUVA, ciclosporin, methotrexate and acitretin developed eruptive squamous cell carcinoma after seven doses of adalimumab. We review the association of squamous cell carcinoma with immunosuppressive agents used for the treatment of chronic plaque psoriasis. Initiation of tumour necrosis factor (TNF)-α inhibitors in a patient at high risk of non-melanoma skin cancer may warrant chemoprophylaxis with acitretin.
authors: Department of Dermatology, Waikato Hospital, Hamilton, New Zealand. susansimpkin@gmail.com
authors: Susan
authors: S
authors: Simpkin
authors: Amanda
authors: A
authors: Oakley
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000068879:Adalimumab; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D011565:Psoriasis / Q000473:pathology* / Q000628:therapy*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; D007641:Keratolytic Agents; D000068879:Adalimumab; D017255:Acitretin