title: Rottlerin and curcumin: a comparative analysis.
abstract: Rottlerin and curcumin are natural plant polyphenols with a long tradition in folk medicine. Over the past two decades, curcumin has been extensively investigated, while rottlerin has received much less attention, in part, as a consequence of its reputation as a selective PKCδ inhibitor. A comparative analysis of genomic, proteomic, and cell signaling studies revealed that rottlerin and curcumin share a number of targets and have overlapping effects on many biological processes. Both molecules, indeed, modulate the activity and/or expression of several enzymes (PKCδ, heme oxygenase, DNA methyltransferase, cyclooxygenase, lipoxygenase) and transcription factors (NF-κB, STAT), and prevent aggregation of different amyloid precursors (α-synuclein, amyloid Aβ, prion proteins, lysozyme), thereby exhibiting convergent antioxidant, anti-inflammatory, and antiamyloid actions. Like curcumin, rottlerin could be a promising candidate in the fight against a variety of human diseases.
authors: Department of Physiology, University of Siena, Siena, Italy. emanuela.maioli@unisi.it
authors: Emanuela
authors: E
authors: Maioli
authors: Claudia
authors: C
authors: Torricelli
authors: Giuseppe
authors: G
authors: Valacchi
mesh_terms: D000098:Acetophenones / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D001578:Benzopyrans / Q000032:analysis / Q000494:pharmacology*; D003474:Curcumin / Q000032:analysis / Q000494:pharmacology*; D044127:Epigenesis, Genetic / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D008517:Phytotherapy / Q000379:methods; D028321:Plant Preparations / Q000032:analysis / Q000494:pharmacology; D051745:Protein Kinase C-delta / Q000037:antagonists & inhibitors; D047428:Protein Kinase Inhibitors / Q000032:analysis / Q000494:pharmacology
chemical_list: D000098:Acetophenones; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001578:Benzopyrans; D028321:Plant Preparations; D047428:Protein Kinase Inhibitors; C085746:rottlerin; D051745:Protein Kinase C-delta; D003474:Curcumin