title: ¹H, ¹³C and ¹⁵N assignment of D2 domain of human fibroblast growth factor receptor 4.
abstract: Fibroblast growth factor receptor (FGFR) 4 has been associated with progression of melanoma, breast, head and neck and hepatocellular carcinoma and is therefore an interesting target for therapeutic intervention (Ho et al. in J Hepatol 50:118-127, 2009). The extracellular D2 domain of the FGFR4 receptor contains a heparin binding site and the main interaction site with the fibroblast growth factor. We report the sequential backbone and side chain resonance assignment of the D2 domain of human FGFR4.
authors: Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438 Frankfurt, Germany.
authors: Bettina
authors: B
authors: Elshorst
authors: Krishna
authors: K
authors: Saxena
authors: Ulrich
authors: U
authors: Schieborr
authors: Harald
authors: H
authors: Schwalbe
mesh_terms: D000595:Amino Acid Sequence; D002247:Carbon Isotopes; D006801:Humans; D008969:Molecular Sequence Data; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary; D011522:Protons; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000737:chemistry*
chemical_list: D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011522:Protons; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4