title: Ability and reproducibility of Fourier-domain optical coherence tomography to detect retinal nerve fiber layer atrophy in Parkinson's disease.
abstract: OBJECTIVE
  To evaluate and compare the ability of 3 protocols of Fourier-domain optical coherence tomography (OCT) to detect retinal thinning and retinal nerve fiber layer (RNFL) atrophy in patients with Parkinson's disease (PD) compared with healthy subjects. To test the intrasession reproducibility of RNFL thickness measurements in patients with PD and healthy subjects using the Cirrus (Carl Zeiss Meditec Inc., Dublin, CA) and Spectralis (Heidelberg Engineering, Inc., Heidelberg, Germany) OCT devices.
  
  
  METHODS
  Observational, cross-sectional study.
  
  
  METHODS
  Patients with PD (n = 75) and age-matched healthy subjects (n = 75) were enrolled.
  
  
  METHODS
  All subjects underwent three 360-degree circular scans centered on the optic disc by the same experienced examiner using the Cirrus OCT instrument, the classic glaucoma application, and the new Nsite Axonal Analytics of the Spectralis OCT instrument.
  
  
  METHODS
  Differences between the eyes of healthy subjects and the eyes of patients with PD were compared using the 3 protocols. The relationship between measurements provided by each OCT protocol was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation.
  
  
  RESULTS
  Retinal nerve fiber layer atrophy was detected in eyes of patients with PD (P = 0.025, P=0.042, and P < 0.001) with the 3 protocols used, but the Nsite Axonal Analytics of the Spectralis OCT device was the most sensitive for detecting subclinical defects. In eyes of patients with PD, RNFL thickness measurements determined by the OCT devices were correlated, but they were significantly different between the Cirrus and Spectralis devices (P = 0.038). Reproducibility was good with all 3 protocols but better using the Glaucoma application of the Spectralis OCT device.
  
  
  CONCLUSIONS
  Fourier-domain OCT can be considered a valid and reproducible device for detecting subclinical RNFL atrophy in patients with PD, especially the Nsite Axonal Analytics of the Spectralis device. Retinal nerve fiber layer thickness measurements differed significantly between the Cirrus and Spectralis devices despite a high correlation of the measurements between the 2 instruments.
authors: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. egmvivax@yahoo.com
authors: Elena
authors: E
authors: Garcia-Martin
authors: Maria
authors: M
authors: Satue
authors: Isabel
authors: I
authors: Fuertes
authors: Sofia
authors: S
authors: Otin
authors: Raquel
authors: R
authors: Alarcia
authors: Raquel
authors: R
authors: Herrero
authors: Maria P
authors: MP
authors: Bambo
authors: Javier
authors: J
authors: Fernandez
authors: Luis E
authors: LE
authors: Pablo
mesh_terms: D000368:Aged; D001284:Atrophy / Q000175:diagnosis; D001369:Axons / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*