title: Two cases of tuberculosis with multiple drug hypersensitivity after drug-induced hypersensitivity syndrome.
abstract: Here, we report 2 cases of drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine and allopurinol during tuberculosis treatment. Both patients also developed multiple drug hypersensitivity (MDH) to several antituberculosis drugs that were used at around the period of DIHS onset, and thus, the treatment could not be successfully completed. Our cases show that MDH can easily occur after development of DIHS. Considering that treatment for tuberculosis requires long-term management with several drugs, it is important to refrain from administering drugs that can cause DIHS during tuberculosis treatment.
authors: Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital, Terunuma 825, Tokai-mura, Naka-gun, Ibaraki, Japan. Akimasa.Sekine@gmail.com
authors: Akimasa
authors: A
authors: Sekine
authors: Takefumi
authors: T
authors: Saito
authors: Shusaku
authors: S
authors: Ito
authors: Yoshiya
authors: Y
authors: Tsunoda
authors: Yuki
authors: Y
authors: Sumazaki
authors: Toru
authors: T
authors: Tanaka
authors: Hiroyuki
authors: H
authors: Takoi
authors: Shih-Yuan
authors: SY
authors: Lin
authors: Yohei
authors: Y
authors: Yatagai
authors: Kenji
authors: K
authors: Hayasihara
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D010495:Pericarditis, Tuberculous / Q000188:drug therapy*; D012867:Skin / Q000473:pathology; D012460:Sulfasalazine / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D012460:Sulfasalazine; D000493:Allopurinol