title: Successful treatment of osteomalacia caused by renal tubular acidosis associated with Sjögren's syndrome.
abstract: A 62-year-old woman was diagnosed with severe osteomalacia caused by renal tubular acidosis associated with Sjögren's syndrome. She was treated with sodium bicarbonate, risedronate, alfacalcidol, and prednisolone (1 mg/kg). By 24 months, renal tubular acidosis was improved and the bone density had normalized. Here we report the successful amelioration of bone lesions through a multidisciplinary approach that improved renal tubular acidosis, with a special focus on treatment of the underlying inflammatory disorder with glucocorticoids.
authors: The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
authors: Sunao
authors: S
authors: Yamamoto
authors: Yosuke
authors: Y
authors: Okada
authors: Hiroko
authors: H
authors: Mori
authors: Shintaro
authors: S
authors: Hirata
authors: Kazuyoshi
authors: K
authors: Saito
authors: Nobuo
authors: N
authors: Inokuchi
authors: Yoshiya
authors: Y
authors: Tanaka
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D012968:Etidronic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D008875:Middle Aged; D010018:Osteomalacia / Q000188:drug therapy* / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D000068296:Risedronic Acid; D012859:Sjogren's Syndrome / Q000150:complications*; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D005938:Glucocorticoids; D006887:Hydroxycholecalciferols; D017693:Sodium Bicarbonate; D011239:Prednisolone; D000068296:Risedronic Acid; D012968:Etidronic Acid; C008088:alfacalcidol