title: Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?
abstract: For the past few decades, there has been a considerable research interest in the area of oral drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been used as a physical approach to improve the solubility and the stability of active pharmaceutical ingredients (APIs) in the gastrointestinal juices, to enhance the intestinal permeability of drugs, to sustain and to control the release of encapsulated APIs allowing the dosing frequency to be reduced, and finally, to achieve both local and systemic drug targeting. Numerous materials have been used in the formulation of oral NPs leading to different nanoparticulate platforms. In this paper, we review various aspects of the formulation and the characterization of polymeric, lipid, and inorganic NPs. Special attention will be dedicated to their performance in the oral delivery of drug molecules and therapeutic genes.
authors: Pharmaceutical Technology Group, CITHÉFOR EA 3452, Faculty of Pharmacy, University of Lorraine, 54001, Nancy Cedex, France. roudayna.diab@pharma.uhp-nancy.fr
authors: Roudayna
authors: R
authors: Diab
authors: Chiraz
authors: C
authors: Jaafar-Maalej
authors: Hatem
authors: H
authors: Fessi
authors: Philippe
authors: P
authors: Maincent
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004355:Drug Stability; D006801:Humans; D007408:Intestinal Absorption; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D012995:Solubility
chemical_list: D004337:Drug Carriers; D008055:Lipids; D004364:Pharmaceutical Preparations; D011108:Polymers