title: A case series of 130 neonates with congenital syphilis: preterm neonates had more clinical evidences of infection than term neonates.
abstract: BACKGROUND
  The early clinical manifestations of congenital syphilis (CS) vary from asymptomatic to florid lesions, involving multisystem damage. But little is known about the differences of early clinical features between preterm and term neonates with CS.
  
  
  OBJECTIVE
  To compare the clinical characteristics between preterm and term neonates with CS and analyze the possible underlying reasons for the differences.
  
  
  METHODS
  Consecutive medical charts of infants at risk for CS from January 1999 to December 2009 were retrospectively reviewed. Neonates with positive 19S-IgM in serum were included in the study.
  
  
  RESULTS
  Among the 1,670 cases at risk for CS, 130 neonatal cases with positive 19S-IgM in serum were included in the analysis, including 58 preterm ones and 72 full-term ones. Compared with term neonates with CS, preterm ones were more likely to have characteristic skin rash (36.2 vs. 9.7%, p < 0.001), hepatomegaly (51.7 vs. 25%, p = 0.02), splenomegaly (32.8 vs. 15.4%, p = 0.02), PRP titer ≥1:8 (96.6 vs. 70.8%, p < 0.001), thrombocytopenia (43.1 vs. 23.6%, p = 0.018), elevated CRP (65.5 vs. 36.5%, p = 0.002), and abnormal long bone X-ray results (94.6 vs. 68.1%, p < 0.001). Fewer mothers of preterm neonates with CS received treatment for syphilis (15.5 vs. 40.3%, p = 0.003). The rate of withdrawal of care was higher in preterm neonates with CS (31 vs.12.5%, p = 0.036).
  
  
  CONCLUSIONS
  Preterm neonates with CS had more clinical evidences and suffered more than term ones.
authors: Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
authors: Qinhua
authors: Q
authors: Zhou
authors: Laishuan
authors: L
authors: Wang
authors: Chao
authors: C
authors: Chen
authors: Yun
authors: Y
authors: Cao
authors: Weili
authors: W
authors: Yan
authors: Wenhao
authors: W
authors: Zhou
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005865:Gestational Age; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013590:Syphilis, Congenital / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D014210:Treponema pallidum / Q000276:immunology; D028761:Withholding Treatment; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007075:Immunoglobulin M