title: A118G mu opioid receptor polymorphism among drug addicts in Malaysia.
abstract: Drug addiction is an important social problem in many countries. Genetic and environmental factors contribute to the predisposition of drug addiction. Genetic variations at the μ opioid receptor (OPRM1) gene locus have been associated with opiate addiction. The present study aims to delineate the frequency of A118G allele of OPRM1 among Malaysian subjects. The frequency of A allele and G allele were 51% and 49%, respectively for addicts and about 73% and 27% respectively for healthy volunteers. The frequency of G allele was 1.77-fold higher in addicts by odds ratio calculation at 95% Cl, which indicate the G allele to be strongly associated with addiction X(2) = 15.31,P < 0.0001; odds ratio 2.51; 95% Cl (1.575-3.994), compared to healthy volunteers. A significant association was observed between A118G polymorphism in μ opioid receptor gene and drug addiction.
authors: Faculty of Applied Sciences, AIMST University, Kedah, Malaysia. devakisen121@yahoo.com
authors: Devaki
authors: D
authors: Nagaya
authors: Surash
authors: S
authors: Ramanathan
authors: Manickam
authors: M
authors: Ravichandran
authors: Visweswaran
authors: V
authors: Navaratnam
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008296:Malaysia; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019966:Substance-Related Disorders / Q000235:genetics*
chemical_list: C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu