title: Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.
abstract: Although interleukin (IL)-7 is mostly known as a key regulator of lymphocyte homeostasis, we recently demonstrated that it also contributes to body weight regulation through a hypothalamic control. Previous studies have shown that IL-7 is produced by the human obese white adipose tissue (WAT) yet its potential role on WAT development and function in obesity remains unknown. Here, we first show that transgenic mice overexpressing IL-7 have reduced adipose tissue mass associated with glucose and insulin resistance. Moreover, in the high-fat diet (HFD)-induced obesity model, a single administration of IL-7 to C57BL/6 mice is sufficient to prevent HFD-induced WAT mass increase and glucose intolerance. This metabolic protective effect is accompanied by a significant decreased inflammation in WAT. In lymphocyte-deficient HFD-fed SCID mice, IL-7 injection still protects from WAT mass gain. However, IL-7-triggered resistance against WAT inflammation and glucose intolerance is lost in SCID mice. These results suggest that IL-7 regulates adipose tissue mass through a lymphocyte-independent mechanism while its protective role on glucose homeostasis would be relayed by immune cells that participate to WAT inflammation. Our observations establish a key role for IL-7 in the complex mechanisms by which immune mediators modulate metabolic functions.
authors: Laboratory of Neuroimmunoendocrinology, Institut Fédératif de Recherche (IFR) 142, Univ Lille Nord de France, Institut Pasteur, Lille, France.
authors: Stéphanie
authors: S
authors: Lucas
authors: Solenne
authors: S
authors: Taront
authors: Christophe
authors: C
authors: Magnan
authors: Laurence
authors: L
authors: Fauconnier
authors: Myriam
authors: M
authors: Delacre
authors: Laurence
authors: L
authors: Macia
authors: Anne
authors: A
authors: Delanoye
authors: Claudie
authors: C
authors: Verwaerde
authors: Corentin
authors: C
authors: Spriet
authors: Pasquine
authors: P
authors: Saule
authors: Gautier
authors: G
authors: Goormachtigh
authors: Laurent
authors: L
authors: Héliot
authors: Alain
authors: A
authors: Ktorza
authors: Jamileh
authors: J
authors: Movassat
authors: Renata
authors: R
authors: Polakowska
authors: Claude
authors: C
authors: Auriault
authors: Odile
authors: O
authors: Poulain-Godefroy
authors: James
authors: J
authors: Di Santo
authors: Philippe
authors: P
authors: Froguel
authors: Isabelle
authors: I
authors: Wolowczuk
mesh_terms: D052436:Adipose Tissue, White / Q000473:pathology*; D000818:Animals; D059305:Diet, High-Fat; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000150:complications; D007333:Insulin Resistance; D015851:Interleukin-7 / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D009765:Obesity / Q000150:complications / Q000473:pathology / Q000517:prevention & control; D009929:Organ Size / Q000187:drug effects; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology; D020395:Receptors, Interleukin-7 / Q000378:metabolism; D017154:Stromal Cells
chemical_list: D015851:Interleukin-7; D020011:Protective Agents; D020395:Receptors, Interleukin-7; C576410:interleukin-7, mouse