title: Pentraxin-3 expression in acute renal allograft rejection.
abstract: Pentraxin-3 (PTX3) is an acute phase reactant produced by a variety of cell types at sites of local inflammation. We examined by immunohistochemistry renal biopsies from patients with acute rejection (n = 10), protocol biopsies without rejection (n = 37), and peri-operative donor biopsies of the same transplant patients (n = 94) for intra-renal expression of PTX3, and its correlation with clinical, laboratory, and histopathologic parameters. PTX3 was mainly expressed in the interstitium of renal allograft. In the non-rejection biopsies (pre- and post-reperfusion and protocol biopsies), PTX3 expression area (PTX3%) was equally maintained at a low level, whereas in the rejection biopsies, PTX3% was significantly higher (p < 0.0001). Treatment of acute rejection resulted in a significant reduction of PTX3% (p < 0.0001). PTX3% positively correlated with the degree of allograft dysfunction and acute rejection scores of Banff classification (2009). This study suggests that PTX3% may be an available histological marker of acute renal allograft rejection.
authors: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. imain@med.niigata-u.ac.jp
authors: Naofumi
authors: N
authors: Imai
authors: Shinichi
authors: S
authors: Nishi
authors: Kazuhiro
authors: K
authors: Yoshita
authors: Yumi
authors: Y
authors: Ito
authors: Yutaka
authors: Y
authors: Osawa
authors: Kaori
authors: K
authors: Takahashi
authors: Yuki
authors: Y
authors: Nakagawa
authors: Kazuhide
authors: K
authors: Saito
authors: Kota
authors: K
authors: Takahashi
authors: Ichiei
authors: I
authors: Narita
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D014184:Transplantation, Homologous; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins