title: The lL-8 and IL-13 gene polymorphisms in inflammatory bowel disease and colorectal cancer.
abstract: Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are disorders that originate from immune disturbances. In our study, we evaluated the association between the -251 T/A interleukin (IL)-8 and the -1112 C/T IL-13 polymorphisms, the risk of IBD, and CRC development. Genotypes were determined by PCR-restriction fragment length polymorphism in 191 patients with CRC, 150 subjects with IBD, and 205 healthy controls. We found an association between CRC and the presence of the -251 TA genotype and A allele of the IL-8 gene (odds ratios [ORs] 2.28 and 1.65). A similar relationship was observed between these polymorphic variants and ulcerative colitis (OR 2.05 for the -251 TA genotype and OR 1.47 for the -251 A allele) as well as Crohn's disease (ORs 3.11 and 1.56, respectively). Our research also revealed that the CT and TT genotypes of the IL-13 -1112 C/T polymorphism may be connected with a higher risk of CRC (ORs 2.28 and 1.65). The same genotypes affected the susceptibility of IBD (ORs 2.26 and 3.72). Our data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the IBD and CRC occurrence and might be used as predictive factors of these diseases in a Polish population.
authors: Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland.
authors: Anna
authors: A
authors: Walczak
authors: Karolina
authors: K
authors: Przybylowska
authors: Lukasz
authors: L
authors: Dziki
authors: Andrzej
authors: A
authors: Sygut
authors: Cezary
authors: C
authors: Chojnacki
authors: Jan
authors: J
authors: Chojnacki
authors: Adam
authors: A
authors: Dziki
authors: Ireneusz
authors: I
authors: Majsterek
mesh_terms: D000328:Adult; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D018793:Interleukin-13 / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic
chemical_list: D018793:Interleukin-13; D016209:Interleukin-8