title: Tetraazacalix[2]arene[2]triazine modified silica gel: a novel multi-interaction stationary phase for mixed-mode chromatography.
abstract: A novel multi-interaction and mixed-mode stationary phase based on tetraazacalix[2]arene[2]triazine modified silica (NCS) was synthesized and characterized by infrared spectra, elemental analysis and thermogravimetric analysis. Mechanism involved in the chromatographic separation is the multi-interaction including hydrophobic, π-π, hydrogen-bonding, inclusion and anion-exchange interactions. Based on these interactions, successful separation could be achieved among polycyclic aromatic hydrocarbons, aromatic position isomers, organic bases and phenols in reversed-phase chromatography. Inorganic anions were also shown to be individually separated in anion-exchange chromatography by using the same column. Moreover, the results here also demonstrated that NCS based stationary phase could effectively reduce the adverse effect of residual silanol in the separation process. Such stationary phase with characteristics of multi-interaction mechanism and mixed-mode separation is potential for the analysis of complex samples.
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
authors: Wenjie
authors: W
authors: Zhao
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China.
authors: Wenjing
authors: W
authors: Wang
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China.
authors: Hong
authors: H
authors: Chang
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China.
authors: Shiwei
authors: S
authors: Cui
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China.
authors: Kai
authors: K
authors: Hu
authors: School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
authors: Lijun
authors: L
authors: He
authors: School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
authors: Kui
authors: K
authors: Lu
authors: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address: liujinxia@zzu.edu.cn.
authors: Jinxia
authors: J
authors: Liu
authors: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors: Yangjie
authors: Y
authors: Wu
authors: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors: Jiang
authors: J
authors: Qian
authors: Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China. Electronic address: zsszz@126.com.
authors: Shusheng
authors: S
authors: Zhang
mesh_terms: D000838:Anions / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D056148:Chromatography, Reverse-Phase / Q000295:instrumentation* / Q000379:methods; D057927:Hydrophobic and Hydrophilic Interactions; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000302:isolation & purification; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000737:chemistry*; D014227:Triazines / Q000737:chemistry*
chemical_list: D000838:Anions; D010636:Phenols; D011084:Polycyclic Aromatic Hydrocarbons; D014227:Triazines; D047250:Calixarenes; D012822:Silicon Dioxide