title: Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
abstract: We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
authors: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Xiangfeng
authors: X
authors: Lu
authors: Laiyuan
authors: L
authors: Wang
authors: Shufeng
authors: S
authors: Chen
authors: Lin
authors: L
authors: He
authors: Xueli
authors: X
authors: Yang
authors: Yongyong
authors: Y
authors: Shi
authors: Jing
authors: J
authors: Cheng
authors: Liang
authors: L
authors: Zhang
authors: C Charles
authors: CC
authors: Gu
authors: Jianfeng
authors: J
authors: Huang
authors: Tangchun
authors: T
authors: Wu
authors: Yitong
authors: Y
authors: Ma
authors: Jianxin
authors: J
authors: Li
authors: Jie
authors: J
authors: Cao
authors: Jichun
authors: J
authors: Chen
authors: Dongliang
authors: D
authors: Ge
authors: Zhongjie
authors: Z
authors: Fan
authors: Ying
authors: Y
authors: Li
authors: Liancheng
authors: L
authors: Zhao
authors: Hongfan
authors: H
authors: Li
authors: Xiaoyang
authors: X
authors: Zhou
authors: Lanying
authors: L
authors: Chen
authors: Donghua
authors: D
authors: Liu
authors: Jingping
authors: J
authors: Chen
authors: Xiufang
authors: X
authors: Duan
authors: Yongchen
authors: Y
authors: Hao
authors: Ligui
authors: L
authors: Wang
authors: Fanghong
authors: F
authors: Lu
authors: Zhendong
authors: Z
authors: Liu
authors: Cailiang
authors: C
authors: Yao
authors: Chong
authors: C
authors: Shen
authors: Xiaodong
authors: X
authors: Pu
authors: Lin
authors: L
authors: Yu
authors: Xianghua
authors: X
authors: Fang
authors: Lihua
authors: L
authors: Xu
authors: Jianjun
authors: J
authors: Mu
authors: Xianping
authors: X
authors: Wu
authors: Runping
authors: R
authors: Zheng
authors: Naqiong
authors: N
authors: Wu
authors: Qi
authors: Q
authors: Zhao
authors: Yun
authors: Y
authors: Li
authors: Xiaoli
authors: X
authors: Liu
authors: Mengqin
authors: M
authors: Wang
authors: Dahai
authors: D
authors: Yu
authors: Dongsheng
authors: D
authors: Hu
authors: Xu
authors: X
authors: Ji
authors: Dongshuang
authors: D
authors: Guo
authors: Dongling
authors: D
authors: Sun
authors: Qianqian
authors: Q
authors: Wang
authors: Ying
authors: Y
authors: Yang
authors: Fangchao
authors: F
authors: Liu
authors: Qunxia
authors: Q
authors: Mao
authors: Xiaohua
authors: X
authors: Liang
authors: Jingfeng
authors: J
authors: Ji
authors: Panpan
authors: P
authors: Chen
authors: Xingbo
authors: X
authors: Mo
authors: Dianjiang
authors: D
authors: Li
authors: Guoping
authors: G
authors: Chai
authors: Yida
authors: Y
authors: Tang
authors: Xiangdong
authors: X
authors: Li
authors: Zhenhan
authors: Z
authors: Du
authors: Xuehui
authors: X
authors: Liu
authors: Chenlong
authors: C
authors: Dou
authors: Zili
authors: Z
authors: Yang
authors: Qingjie
authors: Q
authors: Meng
authors: Dong
authors: D
authors: Wang
authors: Renping
authors: R
authors: Wang
authors: Jun
authors: J
authors: Yang
authors: Heribert
authors: H
authors: Schunkert
authors: Nilesh J
authors: NJ
authors: Samani
authors: Sekar
authors: S
authors: Kathiresan
authors: Muredach P
authors: MP
authors: Reilly
authors: Jeanette
authors: J
authors: Erdmann
authors: Xiaozhong
authors: X
authors: Peng
authors: Xigui
authors: X
authors: Wu
authors: Depei
authors: D
authors: Liu
authors: Yuejin
authors: Y
authors: Yang
authors: Runsheng
authors: R
authors: Chen
authors: Boqin
authors: B
authors: Qiang
authors: Dongfeng
authors: D
authors: Gu
mesh_terms: D044466:Asian People / Q000235:genetics*; D000071797:Butyrophilins; D016022:Case-Control Studies; D002681:China; D002874:Chromosome Mapping; D003324:Coronary Artery Disease / Q000235:genetics*; D003598:Cytoskeletal Proteins; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006162:Guanylate Cyclase / Q000235:genetics; D053823:Hedgehog Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008562:Membrane Glycoproteins / Q000235:genetics; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D000071756:Soluble Guanylyl Cyclase; D044465:White People / Q000235:genetics
chemical_list: C506952:ATP2B1 protein, human; C408263:BTNL2 protein, human; D000071797:Butyrophilins; D003598:Cytoskeletal Proteins; C000605660:GUCY1A2 protein, human; D053823:Hedgehog Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C558596:WDR35 protein, human; D053499:Plasma Membrane Calcium-Transporting ATPases; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase