title: Chemoimmunotherapy as long-term maintenance therapy for cancer.
abstract: Homeostatic immune regulatory mechanisms can mediate premature termination of therapy-induced antitumor T-effector cell responses. Administration of cyclophosphamide (CY) prior to intratumoral IL-12 and GM-CSF delivery blocked post-treatment T-suppressor cell rebound via elimination of the pre-existing T-suppressor cell pool, allowed repeated activation of antitumor cytotoxic T-cells and resulted in the cure of advanced spontaneous tumors.
authors: Department of Microbiology and Immunology; School of Medicine and Biomedical Sciences; University at Buffalo; Buffalo, NY USA.
authors: Nejat K
authors: NK
authors: Egilmez
authors: Jamie L
authors: JL
authors: Harden
authors: Rachael B
authors: RB
authors: Rowswell-Turner