title: Hepatoprotective effects and antioxidant role of Scutia myrtina on paracetamol induced hepatotoxicity in rats.
abstract: The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitamin E, SOD and CAT (P < 0.05). The effects of EESM were comparable to that of standard drug Silymarin. The results indicate that EESM shows hepatoprotective effects on paracetamol-induced liver damage in rat this may due to antioxidant and free radical scavenging activity of EESM.
authors: Seventh of April University.
authors: Ramanathan Sambath
authors: RS
authors: Kumar
authors: Kupusamy
authors: K
authors: Asokkumar
authors: Nallasamy Venkateswara
authors: NV
authors: Murthy
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D000431:Ethanol; D016166:Free Radical Scavengers / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027823:Rhamnaceae; D012838:Silymarin / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D000082:Acetaminophen; D000431:Ethanol; D010088:Oxidoreductases