title: Therapeutic hypothermia complicated by spontaneous brain stem hemorrhage.
abstract: Hypothermia increases clotting time, which is known as hypothermic coagulopathy. However, prothrombin time and activated partial thromboplastin time prolongation associated with therapeutic hypothermia is usually mild and thus, hypothermic coagulopathy is not considered to cause clinically significant bleeding. On the other hand, PT and aPTT do not seem to reflect the severity of hypothermic coagulopathy. Serious bleeding complications of therapeutic hypothermia has not been reported previously. Herein, we introduce a case of spontaneous brain stem hemorrhage as a complication of therapeutic hypothermia-induced coagulopathy.
authors: Department of Trauma Surgery, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu-si, Gyeonggi-do, Republic of Korea.
authors: Hang Joo
authors: HJ
authors: Cho
authors: Yeon Young
authors: YY
authors: Kyong
authors: Young Min
authors: YM
authors: Oh
authors: Se Min
authors: SM
authors: Choi
authors: Kyoung Ho
authors: KH
authors: Choi
authors: Joo Suk
authors: JS
authors: Oh
mesh_terms: D001933:Brain Stem / Q000098:blood supply*; D016887:Cardiopulmonary Resuscitation; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000175:diagnosis / Q000628:therapy*; D014057:Tomography, X-Ray Computed