title: A novel mouse model of gastric cancer with human gastric microenvironment.
abstract: Mouse models play an irreplaceable role in the in vivo research of human gastric cancer. In this study, we developed a novel human Gastric tissue-derived Orthotopic and Metastatic (GOM) mouse model of human gastric cancer, in which the human normal gastric tissues were implanted subcutaneously into immunodeficient mice to create a human gastric microenvironment. Then, human gastric cancer cells were injected into the implants. GOM model could mimic the interactions between human gastric microenvironment and human gastric cancer cells, which help exhibit the real characteristics of tumor cells, and finally mimic the clinical-like tumor proliferation and metastases of human beings.
authors: Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors: Ming-Jie
authors: MJ
authors: Zheng
authors: Jue
authors: J
authors: Wang
authors: Yuan-Wen
authors: YW
authors: Chen
authors: Lu
authors: L
authors: Xu
authors: Dan-Dan
authors: DD
authors: Xue
authors: Wei
authors: W
authors: Fu
authors: Yi-Fen
authors: YF
authors: Zhang
authors: Qing
authors: Q
authors: Du
authors: Yi
authors: Y
authors: Zhao
authors: Li-Jun
authors: LJ
authors: Ling
authors: Qiang
authors: Q
authors: Ding
authors: Xiao-An
authors: XA
authors: Liu
authors: Xiao-Ming
authors: XM
authors: Zha
authors: Wei
authors: W
authors: Zheng
authors: Tian-Song
authors: TS
authors: Xia
authors: Shui
authors: S
authors: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation / Q000379:methods; D013274:Stomach Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology*