title: History of non-fatal cardiovascular disease in a cohort of Dutch and British patients with haemophilia.
abstract: OBJECTIVE
  Cardiovascular disease (CVD) mortality is reported to be lower in haemophilia patients than in the general population, but information on the occurrence of non-fatal CVD is lacking. The aim of our study was to assess CVD history in a cohort of living haemophilia patients.
  
  
  METHODS
  Retrospective data on the occurrence of myocardial infarction, angina pectoris, ischaemic stroke and intracranial bleeding in 709 living Dutch and British haemophilia patients aged 30 yr or older were analysed and compared with the general age-matched male population.
  
  
  RESULTS
  There was a trend towards a lower cumulative incidence of myocardial infarction (1.7% vs. 4.0%) and ischaemic stroke (0% vs. 1.5%) in patients with severe haemophilia than in the general population, while the occurrence of angina pectoris was similar (3.2 vs. 3.7%). As expected, the cumulative incidence of intracranial bleeding was, on the other hand, significantly increased in haemophilia patients (1.6% vs. 0.4% in the general population).
  
  
  CONCLUSIONS
  Our results suggest a protective effect of severe haemophilia against acute ischaemic CVD.
authors: Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands. d.e.fransenvandeputte@umcutrecht.nl
authors: Dietje E
authors: DE
authors: Fransen van de Putte
authors: Kathelijn
authors: K
authors: Fischer
authors: Michael
authors: M
authors: Makris
authors: R Campbell
authors: RC
authors: Tait
authors: Pratima
authors: P
authors: Chowdary
authors: Peter W
authors: PW
authors: Collins
authors: Karina
authors: K
authors: Meijer
authors: Goris
authors: G
authors: Roosendaal
authors: Roger E G
authors: RE
authors: Schutgens
authors: Eveline P
authors: EP
authors: Mauser-Bunschoten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications*; D015331:Cohort Studies; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D006113:United Kingdom