title: Occurrence and molecular characterization of Klebsiella pneumoniae ST37 clinical isolates producing plasmid-mediated AmpC recovered over a 3-year period.
abstract: We investigated the clinical and microbiological epidemiology of AmpC plasmidic cephalosporinases (pAmpC) in Klebsiella pneumoniae strains resistant to ceftazidime, during a 3-year period (2007-2009). Among 1505 K. pneumoniae, 7 were pAmpC producers. Molecular characterization revealed the spread of a ST37 strain producing DHA-1 within intensive care units and the diffusion of the same plasmid among unrelated strains.
authors: Service de Bactériologie-Hygiène hospitalière, CHU Nantes, 9 quai Moncousu, 44093 Nantes Cedex 01, France.
authors: Marina
authors: M
authors: Illiaquer
authors: Nathalie
authors: N
authors: Caroff
authors: Pascale
authors: P
authors: Bémer
authors: Guillaume G
authors: GG
authors: Aubin
authors: Marie-Emmanuelle
authors: ME
authors: Juvin
authors: Didier
authors: D
authors: Lepelletier
authors: Alain
authors: A
authors: Reynaud
authors: Stéphane
authors: S
authors: Corvec
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002442:Ceftazidime / Q000494:pharmacology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D017720:Molecular Epidemiology; D010957:Plasmids; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002442:Ceftazidime; C048795:AmpC beta-lactamases; D001618:beta-Lactamases