title: Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia.
abstract: Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake. Higher expression of CD71 has been identified as a negative prognostic marker for numerous solid tumor types and for some lymphomas. The aim of this study was to evaluate CD71 expression on acute lymphoblastic leukemia (ALL) cells and to follow its possible clinical correlations. Sixty one patients, aged 1-17 years and diagnosed with ALL, were enrolled in the study. CD71 expression was analyzed on the bone marrow blastic cells by flow cytometry. CD71 expression on the leukemic blasts was diversified; in most patients, all blastic cells showed expression of CD71, but levels of expression varied. CD71 expression was statistically higher on T-lineage leukemias. Within the B lineage ALL, a significant difference in CD71 expression existed between precursor B ALL and mature B-ALL, which showed higher CD71 expression. CD71 expression positively correlated with Hgb concentration at diagnosis. Initial risk group assessment and therapy response were not correlated with CD71 expression, although disease free and overall survival times tended to be shorter in patients with B-lineage leukemias with initial high CD71 expression.
authors: Department of Pathophysiology, Medical University of Gdansk, Poland.
authors: Anna
authors: A
authors: Płoszyńska
authors: Katarzyna
authors: K
authors: Ruckemann-Dziurdzińska
authors: Agnieszka
authors: A
authors: Jóźwik
authors: Anna
authors: A
authors: Mikosik
authors: Katarzyna
authors: K
authors: Lisowska
authors: Anna
authors: A
authors: Balcerska
authors: Jacek M
authors: JM
authors: Witkowski
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000378:metabolism*; D001752:Blast Crisis / Q000097:blood / Q000276:immunology / Q000378:metabolism; D019070:Cell Lineage; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D018572:Disease-Free Survival; D005260:Female; D005434:Flow Cytometry / Q000379:methods*; D005453:Fluorescence; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D009928:Organ Specificity; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015703:Antigens, CD; C068126:CD71 antigen; D006454:Hemoglobins; D011990:Receptors, Transferrin