title: Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
abstract: The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
authors: Cátedra de Química Farmacéutica, DQO, Facultad de Química, UDELAR, Montevideo CP 11800, Uruguay.
authors: Stella
authors: S
authors: Peña
authors: Laura
authors: L
authors: Scarone
authors: Eduardo
authors: E
authors: Manta
authors: Lindsay
authors: L
authors: Stewart
authors: Vanessa
authors: V
authors: Yardley
authors: Simon
authors: S
authors: Croft
authors: Gloria
authors: G
authors: Serra
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000187:drug effects; D046931:Microcystis / Q000378:metabolism*; D010080:Oxazoles / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000962:Antimalarials; D010080:Oxazoles; D010456:Peptides, Cyclic; D013844:Thiazoles; C531483:aerucyclamide B