title: Compared to subcutaneous tenofovir, oral tenofovir disoproxyl fumarate administration preferentially concentrates the drug into gut-associated lymphoid cells in simian immunodeficiency virus-infected macaques.
abstract: To compare tissue-based pharmacokinetics and efficacy of oral tenofovir disoproxyl fumarate (TDF) versus subcutaneous tenofovir (TFV), macaques were treated for 2 weeks starting 1 week after simian immunodeficiency virus inoculation. Despite lower plasma TFV levels in the oral TDF arm, similar TFV diphosphate levels and antiviral activities were measured in lymphoid cells of most tissues. In intestinal tissues, however, oral TDF resulted in higher active drug levels, associated with lower virus levels and better immune preservation.
authors: California National Primate Research Center, University of California, Davis, California, USA. kkvanrompay@ucdavis.edu
authors: Koen K A
authors: KK
authors: Van Rompay
authors: Darius
authors: D
authors: Babusis
authors: Zachary
authors: Z
authors: Abbott
authors: Yongzhi
authors: Y
authors: Geng
authors: Kartika
authors: K
authors: Jayashankar
authors: Jeffrey A
authors: JA
authors: Johnson
authors: Jonathan
authors: J
authors: Lipscomb
authors: Walid
authors: W
authors: Heneine
authors: Kristina
authors: K
authors: Abel
authors: Adrian S
authors: AS
authors: Ray
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007279:Injections, Subcutaneous; D007422:Intestines / Q000737:chemistry / Q000821:virology; D008214:Lymphocytes / Q000737:chemistry / Q000821:virology; D008253:Macaca mulatta; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000187:drug effects* / Q000502:physiology; D000068698:Tenofovir; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D012367:RNA, Viral; D000068698:Tenofovir; D000225:Adenine