title: Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy.
abstract: BACKGROUND
  The differences in the small intestinal toxicity of low-dose aspirin based on the type of aspirin used remains unclear. The purpose of this study was to evaluate the differences in the small bowel mucosal injury between buffered and enteric-coated aspirin users by capsule endoscopy.
  
  
  METHODS
  We retrospectively reviewed the findings in chronic low-dose aspirin users (>3 months) who underwent capsule endoscopy for the investigation of obscure gastrointestinal bleeding. The patients were classified into two groups based on the type of low-dose aspirin that they had been prescribed (enteric-coated aspirin group or buffered aspirin group), and evaluated the numbers of small bowel lesions and the Lewis score.
  
  
  RESULTS
  Capsule-endoscopic findings of a total of 70 patients taking low-dose aspirin were reviewed. Significant differences in the number of erosions and ulcers were observed between the buffered and enteric-coated aspirin groups (P=0.017 and P=0.037, respectively). The median Lewis score for the small bowel mucosal inflammatory change was significantly higher in the enteric-coated aspirin group than in the buffered aspirin group (P=0.035).
  
  
  CONCLUSIONS
  The results of this study suggested that enteric-coated aspirin might be more injurious to the small bowel mucosa than buffered aspirin.
authors: Division of Endoscopy, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. endo1978@yokohama-cu.ac.jp
authors: Hiroki
authors: H
authors: Endo
authors: Eiji
authors: E
authors: Sakai
authors: Takuma
authors: T
authors: Higurashi
authors: Eiji
authors: E
authors: Yamada
authors: Hidenori
authors: H
authors: Ohkubo
authors: Hiroshi
authors: H
authors: Iida
authors: Tomoko
authors: T
authors: Koide
authors: Masato
authors: M
authors: Yoneda
authors: Yasunobu
authors: Y
authors: Abe
authors: Masahiko
authors: M
authors: Inamori
authors: Kunihiro
authors: K
authors: Hosono
authors: Hirokazu
authors: H
authors: Takahashi
authors: Kensuke
authors: K
authors: Kubota
authors: Atsushi
authors: A
authors: Nakajima
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D053704:Capsule Endoscopy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001241:Aspirin