title: Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression.
abstract: Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology.
authors: Department of Immunology; Roswell Park Cancer Institute; Buffalo, NY USA.
authors: Scott I
authors: SI
authors: Abrams
authors: Jeremy D
authors: JD
authors: Waight