title: [Neurokinkin B and it's function on reproductive endocrine].
abstract: Neurokinkin B (NKB) is a member of tachykinin family and plays a role mainly through its receptor NK3R. NKB and NK3R are wide spread through the neural system. Studies revealed that NKB has kinds of biological functions such as constringing the smooth muscle of hollow viscus, relaxing blood vessels, reducing mean arterial pressure, slowing heart rate, exciting in vitro spinal cord neurons of rats and astringing sphincter pupillae. For the past few years, people pay more and more attentions to the regulating action of NKB on reproductive endocrine and a lot of research are made to discuss the function of NKB in HPGA. This article summarizes the distribution and physiological function of NKB and NK3R, discusses their functions in reproductive endocrine. Future studies will be needed to determine the precise mechanism of NKB.
authors: Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
authors: Shi-Ran
authors: SR
authors: Wang
authors: Zhan-Zhuang
authors: ZZ
authors: Tian
mesh_terms: D000818:Animals; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology*; D015287:Neurokinin B / Q000502:physiology*; D051381:Rats; D018042:Receptors, Neurokinin-3 / Q000502:physiology; D012098:Reproduction / Q000502:physiology*
chemical_list: D018042:Receptors, Neurokinin-3; D007987:Gonadotropin-Releasing Hormone; D015287:Neurokinin B; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone