title: Comparison of two preoperative skin antiseptic preparations and resultant surgical incise drape adhesion to skin in healthy volunteers.
abstract: BACKGROUND
  Adhesion of incise drapes is important at the wound edge, where the skin and drapes are contiguous with the wound. Separation of incise drapes from the skin has been reported to be associated with a sixfold increase in the infection rate compared with surgical procedures in which the drape did not lift off. The present study sought to determine whether the choice of preoperative skin preparation affects the adhesion of various incise drapes.
  
  
  METHODS
  Following randomization, the backs of twenty-two healthy volunteers were prepared with two skin preparations, 3M DuraPrep Surgical Solution Patient Preoperative Skin Preparation or ChloraPrep with Tint (Scrub Teal) Patient Preoperative Skin Preparation, according to the label directions. Sample strips (12.7 × 76.2 mm) of three different drapes were applied to the prepared areas and were covered with gauze soaked with saline solution for thirty minutes to simulate a fluid challenge. Drape samples were mechanically removed with use of a peel tester based on an international standard for testing peel adhesion of pressure-sensitive tape. Adverse events were monitored and the skin condition was observed. The primary outcome was drape adhesion, measured as the peel strength in units of gram-force. Outcomes were assessed according to drape type and skin preparation with use of mixed-model analysis of variance.
  
  
  RESULTS
  Skin prepared with DuraPrep solution had significantly greater drape adhesion (mean peel strength, 181 gf) compared with skin prepared with ChloraPrep (79 gf, p < 0.001). Although maintaining good adhesion is important, an incise drape that has excessive adhesion may cause skin irritation. Regardless of the skin preparation used, the skin reaction at the application site ranged from none to moderate erythema, and in no instance constituted an adverse event that required treatment.
  
  
  CONCLUSIONS
  The data suggest that the type of skin preparation affects drape adhesion. For surgical procedures in which incise drapes are used, choosing a skin preparation that enhances drape adhesion may minimize drape lifting and the potential for wound contamination.
authors: cyberDERM Clinical Studies, Lawrence Park Industrial Park, 700 Parkway Drive, Broomall, PA 19008, USA. GGrove@cyberDERM-Inc.com
authors: Gary L
authors: GL
authors: Grove
authors: Chou I
authors: CI
authors: Eyberg
mesh_terms: D019840:2-Propanol / Q000494:pharmacology; D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods; D005260:Female; D006801:Humans; D007455:Iodine / Q000494:pharmacology; D008297:Male; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000379:methods; D011206:Povidone-Iodine / Q000494:pharmacology*; D011300:Preoperative Care / Q000379:methods; D012016:Reference Values; D012867:Skin / Q000187:drug effects / Q000382:microbiology; D058636:Surgical Drapes / Q000382:microbiology*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000494:pharmacology
chemical_list: D000891:Anti-Infective Agents, Local; C515331:DuraPrep; D014014:Tissue Adhesives; D011206:Povidone-Iodine; D007455:Iodine; D019840:2-Propanol