title: Phytochemical and biological studies of Agave attenuata.
abstract: The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541-39.35 GAE, mg/100 g) and total flavonoid contents (43.35-304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%-2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.
authors: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors: Komal
authors: K
authors: Rizwan
authors: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors: Muhammad
authors: M
authors: Zubair
authors: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors: Nasir
authors: N
authors: Rasool
authors: Department of Chemistry, Government College University, Faisalabad 38000, Pakistan.
authors: Muhammad
authors: M
authors: Riaz
authors: Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan.
authors: Muhammad
authors: M
authors: Zia-Ul-Haq
authors: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, I-84084 Fisciano (Salerno), Italy.
authors: Vincenzo
authors: 0000-0002-1070-3207
authors: V
authors: De Feo
mesh_terms: D027882:Agave / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D015227:Lipid Peroxidation / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts