title: Particokinetics: computational analysis of the superparamagnetic iron oxide nanoparticles deposition process.
abstract: BACKGROUND
  Nanoparticles in suspension are often utilized for intracellular labeling and evaluation of toxicity in experiments conducted in vitro. The purpose of this study was to undertake a computational modeling analysis of the deposition kinetics of a magnetite nanoparticle agglomerate in cell culture medium.
  
  
  METHODS
  Finite difference methods and the Crank-Nicolson algorithm were used to solve the equation of mass transport in order to analyze concentration profiles and dose deposition. Theoretical data were confirmed by experimental magnetic resonance imaging.
  
  
  RESULTS
  Different behavior in the dose fraction deposited was found for magnetic nanoparticles up to 50 nm in diameter when compared with magnetic nanoparticles of a larger diameter. Small changes in the dispersion factor cause variations of up to 22% in the dose deposited. The experimental data confirmed the theoretical results.
  
  
  CONCLUSIONS
  These findings are important in planning for nanomaterial absorption, because they provide valuable information for efficient intracellular labeling and control toxicity. This model enables determination of the in vitro transport behavior of specific magnetic nanoparticles, which is also relevant to other models that use cellular components and particle absorption processes.
authors: Instituto do Cérebro, Hospital Israelita Albert Einstein, São Paulo, Brazil. walter.cardenas@einstein.br
authors: Walter H Z
authors: WH
authors: Cárdenas
authors: Javier B
authors: JB
authors: Mamani
authors: Tatiana T
authors: TT
authors: Sibov
authors: Cristofer A
authors: CA
authors: Caous
authors: Edson
authors: E
authors: Amaro
authors: Lionel F
authors: LF
authors: Gamarra
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D018481:Convection; D003470:Culture Media / Q000737:chemistry; D004058:Diffusion; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008962:Models, Theoretical; D010316:Particle Size; D013535:Suspensions / Q000737:chemistry
chemical_list: D003470:Culture Media; D058185:Magnetite Nanoparticles; D013535:Suspensions