title: Insights into the roles of local translation from the axonal transcriptome.
abstract: Much of our knowledge on the roles of intra-axonal translation derives from the characterization of a small number of individual mRNAs that were found to be localized in axons. However, two recent studies, using large-scale approaches to provide a more comprehensive characterization of the axonal transcriptome, have led to the discovery of thousands of axonal mRNAs. The apparent abundance of mRNAs in axons raises the possibility that local translation has many more functions than previously thought. Here, we review the recent studies that have profiled axonal mRNAs and discuss how the identification of axonal transcripts might point to unappreciated roles for local translation in axons.
authors: Graduate Program in Neuroscience, Weill Cornell Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA.
authors: Alessia
authors: A
authors: Deglincerti
authors: Samie R
authors: SR
authors: Jaffrey
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis*; D059467:Transcriptome / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins; D012333:RNA, Messenger