title: Combined effect of sesamin and α-lipoic acid on hepatic fatty acid metabolism in rats.
abstract: OBJECTIVE
  Dietary sesamin (1:1 mixture of sesamin and episesamin) decreases fatty acid synthesis but increases fatty acid oxidation in rat liver. Dietary α-lipoic acid lowers hepatic fatty acid synthesis. These changes can account for the serum lipid-lowering effect of sesamin and α-lipoic acid. It is expected that the combination of these compounds in the diet potentially ameliorates lipid metabolism more than the individual compounds. We therefore studied the combined effect of sesamin and α-lipoic acid on lipid metabolism in rats.
  
  
  METHODS
  Male Sprague-Dawley rats were fed diets supplemented with 0 or 2 g/kg sesamin and containing 0 or 2.5 g/kg α-lipoic acid for 22 days.
  
  
  CONCLUSIONS
  Sesamin and α-lipoic acid decreased serum lipid concentrations and the combination of these compounds further decreased the parameters in an additive fashion. These compounds reduced the hepatic concentration of triacylglycerol, the lignan being less effective in decreasing this value. The combination failed to cause a stronger decrease in hepatic triacylglycerol concentration. The combination of sesamin and α-lipoic acid decreased the activity and mRNA levels of hepatic lipogenic enzymes in an additive fashion. Sesamin strongly increased the parameters of hepatic fatty acid oxidation enzymes. α-Lipoic acid antagonized the stimulating effect of sesamin of fatty acid oxidation through reductions in the activity of some fatty acid oxidation enzymes and carnitine concentration in the liver. This may account for the failure to observe strong reductions in hepatic triacylglycerol concentration in rats given a diet containing both sesamin and α-lipoic acid.
authors: Department of Food and Nutrition, Faculty of Human Life, Jumonji University, 2-1-28 Sugasawa, Niiza, Saitama, 352-8510, Japan, t-ide@jumonji-u.ac.jp
authors: Takashi
authors: T
authors: Ide
authors: Ayana
authors: A
authors: Azechi
authors: Sayaka
authors: S
authors: Kitade
authors: Yoko
authors: Y
authors: Kunimatsu
authors: Natsuko
authors: N
authors: Suzuki
authors: Chihiro
authors: C
authors: Nakajima
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000737:chemistry; D002331:Carnitine / Q000037:antagonists & inhibitors / Q000378:metabolism; D019587:Dietary Supplements; D004149:Dioxoles / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D017705:Lignans / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D050356:Lipid Metabolism; D050155:Lipogenesis; D008066:Lipolysis; D008099:Liver / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D008063:Thioctic Acid / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D015430:Weight Gain
chemical_list: D001067:Appetite Depressants; D004149:Dioxoles; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D017705:Lignans; D012333:RNA, Messenger; D014280:Triglycerides; D008063:Thioctic Acid; C054125:sesamin; D002331:Carnitine