title: Scaffold protein Homer 1: implications for neurological diseases.
abstract: Homer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction. Both an immediate-early gene encoding a Homer 1 variant and a constitutively expressed Homer 1 variant regulate receptor clustering and trafficking, intracellular calcium homeostasis, and intracellular molecule complex formation. Substantial preclinical investigations have implicated that each of these Homer 1 variants are associated with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, drug-induced addiction, and traumatic brain injury.
authors: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
authors: Peng
authors: P
authors: Luo
authors: Xia
authors: X
authors: Li
authors: Zhou
authors: Z
authors: Fei
authors: Waisang
authors: W
authors: Poon
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D000072233:Homer Scaffolding Proteins; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D034521:Nuclear Matrix-Associated Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D034521:Nuclear Matrix-Associated Proteins