title: Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report.
abstract: Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in mantle cell lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall represented by cyclin D1 immunohistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or fluorescence in situ hybridization.
  The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1117747619703769.
authors: Pathology Unit, National Cancer Institute Fondazione Giovanni Pascale, Via Mariano Semmola, 80131 Napoli, Italy.
authors: Gabriella
authors: G
authors: Aquino
authors: Renato
authors: R
authors: Franco
authors: Fioravante
authors: F
authors: Ronconi
authors: Annamaria
authors: A
authors: Anniciello
authors: Luigi
authors: L
authors: Russo
authors: Annarosaria
authors: A
authors: De Chiara
authors: Luigi
authors: L
authors: Panico
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001706:Biopsy; D049109:Cell Proliferation; D019938:Cyclin D1 / Q000032:analysis* / Q000235:genetics; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives; D003951:Diagnostic Errors / Q000517:prevention & control; D017809:Fatal Outcome; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects; D011237:Predictive Value of Tests; D017211:Treatment Failure; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; D009944:Organoplatinum Compounds; D003841:Deoxycytidine; D019938:Cyclin D1