title: The velocity of cardiac sarcomere shortening: mechanisms and implications.
abstract: A classical paper published by Michael Barany almost 50 years ago demonstrated a tight correlation between the mechanical parameter of maximal velocity of shortening and the biochemical parameter of myosin ATPase activity in a wide spectrum of species. Here, we review the determinants of muscle dynamics by mechanical load and the relation between sarcomere shortening velocity and cross-bridge dynamics in rat myocardium containing a range of fast and slow myosin. Observations from molecular level to mechanics of the intact human heart suggest that cardiac actin-myosin kinetic properties are matched so as to optimize myocardial strain rate and allow for the maximum rate of hydraulic energy output observed during ejection in the whole ventricle.
authors: Department of Cell and Molecular Physiology, Loyola University School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA.
authors: Pieter P
authors: PP
authors: de Tombe
authors: Henk E D J
authors: HE
authors: ter Keurs
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D024722:Cardiac Myosins / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009200:Myocardial Contraction; D012518:Sarcomeres / Q000378:metabolism*
chemical_list: D000199:Actins; D024722:Cardiac Myosins