title: Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation.
abstract: The effectiveness of cetuximab (Cmab) against KRAS p.G13D mutant-type tumors has been reported. In this study, we report a case of metastatic ascending colon cancer harboring a KRAS p.G13D mutation in a 65-year-old female. Considering the absence of symptoms and the post-operative risk of respiratory system complications due to multiple lung metastases, particularly at the entrance to the left main bronchus, anticancer drug therapy was selected as first-line therapy. With informed consent, FOLFOX4 [folinic acid (FOL), fluorouracil (F) plus oxaliplatin (OX)] + Cmab therapy was administered as preoperative chemotherapy. A good preoperative response was obtained to the chemotherapy, with a metastatic lesion disappearing from the entrance to the left main bronchus. Subsequent resection was performed successfully with no post-operative complications. Although a histopathological examination of the resected tissue specimen revealed residual cancer cells, it also showed the marked efficacy of the chemotherapy regimen used. In this study, we describe a case of metastatic ascending colon cancer harboring a KRAS p.G13D mutation in which the patient responded well to first-line therapy with FOLFOX4 + Cmab.
authors: Department of Surgery, Tobu Chiiki Hospital, Metropolitan Health and Medical Treatment Corporation, Tokyo 125-8512.
authors: Takumi
authors: T
authors: Ochiai
authors: Kazuhiko
authors: K
authors: Nishimura
authors: Tomoo
authors: T
authors: Watanabe
authors: Masayuki
authors: M
authors: Kitajima
authors: Akinori
authors: A
authors: Nakatani
authors: Takashi
authors: T
authors: Inou
authors: Marie
authors: M
authors: Washio
authors: Naoki
authors: N
authors: Sakuyama
authors: Tsuyoshi
authors: T
authors: Sato
authors: Kenji
authors: K
authors: Kishine
authors: Takanori
authors: T
authors: Ochi
authors: Satoshi
authors: S
authors: Ookubo
authors: Shunji
authors: S
authors: Futagawa
authors: Hideki
authors: H
authors: Orikasa
authors: Satomi
authors: S
authors: Mashiko
authors: Isao
authors: I
authors: Nagaoka