title: Reduced CD151 expression is related to advanced tumour stage in urothelial bladder cancer.
abstract: OBJECTIVE
  CD151 belongs to the group of tetraspanins and is aberrantly expressed in different tumours and differential expression has been associated with prognosis. The aim of this study was to clarify the relationship of CD151 expression with tumour phenotype and clinical outcome in bladder cancer.
  
  
  METHODS
  A bladder cancer tissue microarray containing samples from 686 urothelial bladder cancers was analysed by immunohistochemistry.
  
  
  RESULTS
  Membranous CD151 immunostaining was recorded in 409 (66.0%) of 620 analysable cases. High CD151 expression was seen in normal urothelium and in most non-invasive tumours. Low CD151 expression levels were associated with a more unfavourable tumour phenotype. CD151 staining was seen in 71.5% of 284 pTa, 62.1% of 145 pT1 and 60.4% of 187 pT2-4 cancers (p = 0.0033). CD151 staining was detectable in 77.3% of 75 grade 1, 71.1% of 273 grade 2 and 57.7% of 272 grade 3 cancers (p < 0.0001). CD151 expression status was not associated with overall or tumour-specific survival in muscle-invasive cancers (pT2-4), tumour progression in pT1 and recurrences in pTa tumours.
  
  
  CONCLUSIONS
  On the basis of our data we conclude that loss of CD151 may contribute to bladder cancer progression through attenuation of cell adhesion. In clinically defined subgroups CD151 expression does not provide additional prognostic information.
authors: Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.minner@uke.de
authors: Sarah
authors: S
authors: Minner
authors: Colin
authors: C
authors: De Silva
authors: Michael
authors: M
authors: Rink
authors: Roland
authors: R
authors: Dahlem
authors: Felix
authors: F
authors: Chun
authors: Margit
authors: M
authors: Fisch
authors: Wolfgang
authors: W
authors: Höppner
authors: Walter
authors: W
authors: Wagner
authors: Carsten
authors: C
authors: Bokemeyer
authors: Luigi
authors: L
authors: Terracciano
authors: Ronald
authors: R
authors: Simon
authors: Guido
authors: G
authors: Sauter
authors: Waldemar
authors: W
authors: Wilczak
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002448:Cell Adhesion; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D012008:Recurrence; D015996:Survival Rate; D060185:Tetraspanin 24 / Q000378:metabolism*; D046888:Tissue Array Analysis; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D019459:Urothelium / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C554715:CD151 protein, human; D060185:Tetraspanin 24