title: Mitochondrial division in rat cardiomyocytes: an electron microscope study.
abstract: In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves "pinching," in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown.
authors: Electron Microscopy Facility and Center for Mitochondrial Disease, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. hisashi.fujioka@case.edu
authors: Hisashi
authors: H
authors: Fujioka
authors: Bernard
authors: B
authors: Tandler
authors: Charles L
authors: CL
authors: Hoppel
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D008854:Microscopy, Electron / Q000379:methods; D008929:Mitochondria, Heart / Q000502:physiology* / Q000648:ultrastructure*; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000648:ultrastructure*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344