title: Correlation between steroid sex hormones, egg laying capacity and cercarial shedding in Biomphalaria alexandrina snails after treatment with Haplophyllum tuberculatum.
abstract: Schistosomiasis is considered the second most pre-valiant worldwide parasitic disease ranked next to malaria. It has significant economic and public health consequences in many developing countries. Several ways have been practiced in order to bring the disease under an adequate control through the breakage of the life cycle of the parasite. Snail control could be regarded as a rapid and efficient of reducing or eliminating transmission and remains among the methods of choice for schistosomiasis control. The aim of this work is to evaluate the role of Haplophyllum tuberculatum (family Rutaceae) as a plant molluscicide. The mortality rate of Biomphalaria alexandrina snails were monitored after treatment with three extracts of the plant aerial parts; petroleum ether, chloroform and ethanol. Chloroform extract that recorded the most potent effect was further evaluated through measuring the toxicity pattern against B. alexandrina snails, egg laying capacity, cercarial shedding, phenol oxidase enzyme and the levels of steroid sex hormones. Histopathological examination of hepatopancreas and ovotestis of treated snails were also done for result confirmation. Treatment of snails by chloroform extract recorded reduction in egg laying capacity, decrease in cercarial shedding, diminution in phenol oxidase enzyme, disturbance in steroid sex hormones and sever alternation of the histopathological picture of snails tissue. In conclusion, H. tuberculatum recorded molluscicidal potency against B. alexandrina snails. Further studies are needed for its environmental applications.
authors: Therapeutic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
authors: Maha Z
authors: MZ
authors: Rizk
authors: Nadia S
authors: NS
authors: Metwally
authors: Manal A
authors: MA
authors: Hamed
authors: Azza M
authors: AM
authors: Mohamed
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000201:enzymology / Q000469:parasitology / Q000502:physiology / Q000648:ultrastructure; D058487:Cercaria / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D043143:Hepatopancreas / Q000187:drug effects; D007447:Invertebrate Hormones / Q000378:metabolism; D007928:Lethal Dose 50; D008975:Molluscacides; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010058:Oviposition / Q000187:drug effects; D010936:Plant Extracts; D027821:Rutaceae / Q000737:chemistry*; D012550:Schistosoma mansoni / Q000502:physiology
chemical_list: D012739:Gonadal Steroid Hormones; D007447:Invertebrate Hormones; D008975:Molluscacides; D010936:Plant Extracts; D014442:Monophenol Monooxygenase