title: Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake.
abstract: Intestinal gluconeogenesis is involved in the control of food intake. We show that mu-opioid receptors (MORs) present in nerves in the portal vein walls respond to peptides to regulate a gut-brain neural circuit that controls intestinal gluconeogenesis and satiety. In vitro, peptides and protein digests behave as MOR antagonists in competition experiments. In vivo, they stimulate MOR-dependent induction of intestinal gluconeogenesis via activation of brain areas receiving inputs from gastrointestinal ascending nerves. MOR-knockout mice do not carry out intestinal gluconeogenesis in response to peptides and are insensitive to the satiety effect induced by protein-enriched diets. Portal infusions of MOR modulators have no effect on food intake in mice deficient for intestinal gluconeogenesis. Thus, the regulation of portal MORs by peptides triggering signals to and from the brain to induce intestinal gluconeogenesis are links in the satiety phenomenon associated with alimentary protein assimilation.
authors: Institut National de la Santé et de la Recherche Médicale, U 855, Lyon 69372, France.
authors: Celine
authors: C
authors: Duraffourd
authors: Filipe
authors: F
authors: De Vadder
authors: Daisy
authors: D
authors: Goncalves
authors: Fabien
authors: F
authors: Delaere
authors: Armelle
authors: A
authors: Penhoat
authors: Bleuenn
authors: B
authors: Brusset
authors: Fabienne
authors: F
authors: Rajas
authors: Dominique
authors: D
authors: Chassard
authors: Adeline
authors: A
authors: Duchampt
authors: Anne
authors: A
authors: Stefanutti
authors: Amandine
authors: A
authors: Gautier-Stein
authors: Gilles
authors: G
authors: Mithieux
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D004435:Eating; D005943:Gluconeogenesis; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012528:Satiety Response
chemical_list: D004044:Dietary Proteins; D017450:Receptors, Opioid, mu