title: [Efficacy and safety of intraoperative electrical stimulation mapping for resection of WHO grade ii and iii gliomas within eloquent areas].
abstract: OBJECTIVE
  Despite the growing use of intraoperative electrical stimulation (IES) mapping for the resection of WHO grade ii and iii gliomas (GGII and GGIII) in eloquent areas, few studies have compared 2 series with and without IES. The present study compares 2 series of patients operated with and without IES at the same institution, analyzing the extent of resection, neurological morbidity, epilepsy prognosis and quality of life.
  
  
  METHODS
  The surgical results in 2 series of patients with GGII and GGIII within eloquent were compared. Period A (2004-2009): 17 patients operated without IES. Period B (2009-2010): 19 patients operated with IES.
  
  
  RESULTS
  The extent of tumor resection was 54.7% in group A and 79.9% in group B (P=.006). Six months after surgery, neurological morbidity was present in 8 patients of group A and one patient of group B (P=.015; odds ratio [OR] 16, 95% confidence interval [95% CI] 1.7-148.3). Two patients of group A with refractory epilepsy, and 8 patients of group B improved epilepsy control (P=.05; OR 42, 95% CI 2.1-825.7). Nine patients of group A and 18 patients of group B returned to the same socio-professional situation as before surgery (P=.015; OR 16, 95% CI 1.7-148.4).
  
  
  CONCLUSIONS
  The comparison of IES mapping surgery to conventional surgery revealed that the former enables to: increase in 25.2% the extent of tumor resection, decrease in 48.1% the risk of permanent sequelae, improve epilepsy control and preserve quality of life.
authors: Departamento de Neurocirugía, Hospital Universitario Marqués de Valdecilla, Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, España.
authors: David
authors: D
authors: Suárez-Fernández
authors: Alfonso
authors: A
authors: Vázquez-Barquero
authors: Elsa
authors: E
authors: Gómez
authors: Enrique
authors: E
authors: Marco de Lucas
authors: Luis Ángel
authors: LÁ
authors: Lopez
authors: David
authors: D
authors: Mato
authors: Rubén
authors: R
authors: Martín-Láez
authors: Roberto
authors: R
authors: Ocon
authors: Juan
authors: J
authors: Martino
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D002648:Child; D004558:Electric Stimulation; D004827:Epilepsy / Q000209:etiology; D005260:Female; D005910:Glioma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011183:Postoperative Complications / Q000517:prevention & control; D011788:Quality of Life; D016896:Treatment Outcome; D055815:Young Adult