title: Characterization and control of fungal morphology for improved production performance in biotechnology.
abstract: Filamentous fungi have been widely applied in industrial biotechnology for many decades. In submerged culture processes, they typically exhibit a complex morphological life cycle that is related to production performance--a link that is of high interest for process optimization. The fungal forms can vary from dense spherical pellets to viscous mycelia. The resulting morphology has been shown to be influenced strongly by process parameters, including power input through stirring and aeration, mass transfer characteristics, pH value, osmolality and the presence of solid micro-particles. The surface properties of fungal spores and hyphae also play a role. Due to their high industrial relevance, the past years have seen a substantial development of tools and techniques to characterize the growth of fungi and obtain quantitative estimates on their morphological properties. Based on the novel insights available from such studies, more recent studies have been aimed at the precise control of morphology, i.e., morphology engineering, to produce superior bio-processes with filamentous fungi.
authors: Institute of Biochemical Engineering, Technische Universität Braunschweig, Germany. r.krull@tu-braunschweig.de
authors: Rainer
authors: R
authors: Krull
authors: Thomas
authors: T
authors: Wucherpfennig
authors: Manely Eslahpazir
authors: ME
authors: Esfandabadi
authors: Robert
authors: R
authors: Walisko
authors: Guido
authors: G
authors: Melzer
authors: Dietmar C
authors: DC
authors: Hempel
authors: Ingo
authors: I
authors: Kampen
authors: Arno
authors: A
authors: Kwade
authors: Christoph
authors: C
authors: Wittmann
mesh_terms: D057005:Bioengineering / Q000379:methods*; D001709:Biotechnology / Q000379:methods*; D005658:Fungi / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D007218:Industrial Microbiology / Q000379:methods*; D025282:Mycelium / Q000166:cytology / Q000235:genetics / Q000378:metabolism