title: Learning from HSV-infected mice as a model of Behçet's disease.
abstract: Several animal models of Behçet's disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.
authors: Laboratory of Cell Biology, Ajou University School of Medicine, Suwon 433-721, Korea. sohnsh@ajou.ac.kr
authors: S
authors: S
authors: Sohn
authors: E-S
authors: ES
authors: Lee
authors: D
authors: D
authors: Bang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001528:Behcet Syndrome / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006561:Herpes Simplex / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D012307:Risk Factors
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents