title: Cerebral atrophy is associated with development of chronic subdural haematoma.
abstract: OBJECTIVE
  To test that cerebral atrophy is associated with increased risk for development of chronic subdural haematoma (cSDH), this study performed volumetric analysis of computed tomography (CT) brain scans from patients who were diagnosed with cSDH on subsequent CT scans and their age-matched controls.
  
  
  METHODS
  Volumetric analysis was performed on CT scans acquired a mean of 209 days prior to cSDH diagnosis in 19 patients. Cerebral atrophy present on these scans was then compared to 76 age-matched control patients randomly selected from cSDH-free subjects.
  
  
  RESULTS
  There was a higher degree of atrophy in cSDH patients (n = 19, 14.3% ± 5.4%) than in age-matched control patients (n = 76, 11.9% ± 5.5%; p = 0.044). Logistical regression demonstrated that atrophy was found to be a significant predictor of cSDH at all ages (OR = 1.11, 95% CI = [1.01, 1.23], p = 0.05). For younger subjects ≤65 years of age (n = 50), atrophy was an even stronger predictor of cSDH (OR = 1.17, 95% CI = [1.02, 1.34], p = 0.026).
  
  
  CONCLUSIONS
  Cerebral atrophy is associated with the development of cSDH and this association is greater in patients ≤65 years of age.
authors: Department of Neurosurgery, New York University School of Medicine, New York, NY, USA.
authors: Andrew Il
authors: AI
authors: Yang
authors: David S
authors: DS
authors: Balser
authors: Artem
authors: A
authors: Mikheev
authors: Shani
authors: S
authors: Offen
authors: Jason H
authors: JH
authors: Huang
authors: James
authors: J
authors: Babb
authors: Henry
authors: H
authors: Rusinek
authors: Uzma
authors: U
authors: Samadani
mesh_terms: D000367:Age Factors; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003704:Dementia / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D020200:Hematoma, Subdural, Chronic / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology / Q000473:pathology*; D016015:Logistic Models; D008171:Lung Diseases / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014481:United States / Q000453:epidemiology