title: Anxiolytic activity evaluation of four medicinal plants from Cameroon.
abstract: Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C. ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica (M. pudica) are plants used in traditional medicine in Cameroon to treat insomnia, epilepsy, anxiety, and agitation. They were evaluated for their anxiolytic like activity in mice. Animal models (elevated plus maze and stress-induced hyperthermia tests) were used. The four plants showed anxiolytic activity. In stress-induced hyperthermia test, A. laxiflora, C. ambrosioides, M. pyrifolia and M. pudica significantly antagonised the increase of temperature. ΔT° decreased from 0.75°C in the control group to 0.36°C at the dose of 110 mg/kg for A. laxiflora; from 1°C in the control group to -1.1°C at the dose of 120 mg/kg for C. ambrosioides; from 1.7°C in the control group to 0.2°C at the dose of 128 mg/kg for M. pyrifolia and from 1.3°C in the control group to 0.5°C at the dose of 180 mg/kg for M. pudica. In the elevated plus maze test, the four plants increased the number of entries into, percentage of entries into, and percentage of time in open arms. A. laxiflora, C. ambrosioides and M. pudica also reduced the percentage of entries and time in closed arms. In addition, C. ambrosioides, M. pyrifolia and M. pudica showed antipyretic activity by reducing the body temperature. The results suggested that C. ambrosioides, M. pyrifolia and M. pudica posses anxiolytic-like and antipyretic activities while A. laxiflora possesses only anxiolytic-like properties. These plants could be helpful in the treatment of anxiety and fever in traditional medicine in Cameroon.
authors: Department of Biological Sciences, Faculty of Sciences, University of Ngaoundéré, PO Box 454 Ngaoundéré, Cameroon. eli_bum@yahoo.fr
authors: E Ngo
authors: EN
authors: Bum
authors: S
authors: S
authors: Soudi
authors: E R
authors: ER
authors: Ayissi
authors: C
authors: C
authors: Dong
authors: N H
authors: NH
authors: Lakoulo
authors: F
authors: F
authors: Maidawa
authors: P F E
authors: PF
authors: Seke
authors: L D
authors: LD
authors: Nanga
authors: G S
authors: GS
authors: Taiwe
authors: T
authors: T
authors: Dimo
authors: Njifutie
authors: N
authors: Njikam
authors: A
authors: A
authors: Rakotonirina
authors: S V
authors: SV
authors: Rakotonirina
authors: A
authors: A
authors: Kamanyi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002163:Cameroon; D027464:Chenopodium ambrosioides / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000188:drug therapy; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008519:Medicine, Traditional; D051379:Mice; D031298:Mimosa / Q000737:chemistry; D009043:Motor Activity / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D011581:Psychological Tests; D013312:Stress, Physiological
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts