title: Review: Mouse models of inflammatory bowel disease--insights into the mechanisms of inflammation-associated colorectal cancer.
abstract: The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium-immunity-microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.
authors: Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia.
authors: Dessislava
authors: D
authors: Mladenova
authors: Maija R J
authors: MR
authors: Kohonen-Corish
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D016753:Interleukin-10 / Q000502:physiology; D051379:Mice; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D016753:Interleukin-10