title: Tetramolecular quadruplex stability and assembly.
abstract: Guanine quadruplexes (G4) are unusual four-stranded nucleic acid structures formed by G-rich DNA/RNA. Beyond their likely biological relevance, the self-assembly, stability, and rigidity of these structures are also interesting for nanotechnology and biotechnology applications. Therefore, efforts are carried out to understand the rules that govern stability and folding of G-quadruplexes. We focus this chapter on tetramolecular conformations which are simple tractable models. We report here the experimental parameters, molecules, and modifications that affect thermal stability and/or association kinetics of these structures. Some chemical modifications which facilitate tetramolecular quadruplex formation and can be useful for nano- or biotechnology are also described.
authors: Laboratoire ARNA, Université de Bordeaux, 33000, Bordeaux, France, thao.tran@inserm.fr.
authors: Phong Lan Thao
authors: PL
authors: Tran
authors: Anne
authors: A
authors: De Cian
authors: Julien
authors: J
authors: Gros
authors: Rui
authors: R
authors: Moriyama
authors: Jean-Louis
authors: JL
authors: Mergny
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D036103:Nanotechnology / Q000379:methods; D009691:Nucleic Acid Denaturation; D012313:RNA / Q000737:chemistry*
chemical_list: D012313:RNA; D004247:DNA