title: Magnetic resonance imaging can detect thoracic inflammation due to familial Mediterranean fever.
abstract: A 32-year-old man presented to our hospital complaining of periodic fever and unilateral chest pain. We suspected that he had familial Mediterranean fever because of his symptoms. Magnetic resonance imaging (MRI) showed an increased intensity within the anterior chest wall, which was consistent with the site of his pain. Genomic analysis showed the patient to be heterozygous for the E148Q/M694I mutation in the MEFV gene, and we diagnosed familial Mediterranean fever. The ability of MRI to detect inflammatory changes could provide useful additional information for evaluating thoracic symptoms in FMF patients, and the detection of inflammatory changes using MRI may aid in early diagnosis, thus contributing to early and adequate treatment.
authors: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya, Saitama 360-0905, Japan. ishiguro.takashi@pref.saitama.lg.jp
authors: Takashi
authors: T
authors: Ishiguro
authors: Noboru
authors: N
authors: Takayanagi
authors: Kenji
authors: K
authors: Kobayashi
authors: Kiyoshi
authors: K
authors: Migita
authors: Tsutomu
authors: T
authors: Yanagisawa
authors: Toshiko
authors: T
authors: Hoshi
authors: Yutaka
authors: Y
authors: Sugita
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008297:Male; D000071198:Pyrin
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin