title: [Heparin as bridging anticoagulant and antiplatelet therapy during the perioperative period].
abstract: Anticoagulant and antiplatelet medications are commonly used for the treatment and prevention of cardiovascular diseases. We studied 84 patients who received heparin as a bridging anticoagulant and antiplatelet therapy during the perioperative period. Hospitalization was extended for adjusting anticoagulant and antiplatelet drugs and also bleeding complications in the perioperative period. There were 25 instances of bleeding complications (29.7%) in this study. These complications mainly occurred when anticoagulant and antiplatelet medications were restarted in the postoperative period. In transurethral surgery, patients taking warfarin and antiplatelet drugs (aspirin or ticlopidine) had a statistically significant increase in bleeding complications compared to patients taking warfarin alone. We compared 51 cases of transurethral resection of bladder tumor, transurethral resection of the prostate holium laser enucleation of the prostate, nephroureterectomy and percutaneous nephrolithotomy with heparinization were compared to 692 cases with no heparinization. The heparinization group had a statistically significant longer hospitalization period and an increase in bleeding complications. There was one instance of thromboembolism (1.2%) in our series. This involved stent thrombosis of a patient who had drug-eluting stent in the left anterior descending coronary artery. She died three days postoperatively. The number of patients taking anticoagulant and/or antiplatelet drugs is predicted to increase in the future due to aging of the population. Guidelines for the management of anticoagulant and antiplatelet therapy in the urological period are considered necessary.
authors: The Department of Urology, Kurashiki Central Hospital.
authors: Takashi
authors: T
authors: Matsuoka
authors: Koji
authors: K
authors: Inoue
authors: Kei
authors: K
authors: Mizuno
authors: Yuki
authors: Y
authors: Kita
authors: Shotaro
authors: S
authors: Nakanishi
authors: Seiji
authors: S
authors: Asai
authors: Rikiya
authors: R
authors: Taoka
authors: Takeshi
authors: T
authors: Soda
authors: Akito
authors: A
authors: Terai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D059035:Perioperative Period; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013520:Urologic Surgical Procedures
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D006493:Heparin