title: Ni-catalyzed alkenylation of triazolopyridines: synthesis of 2,6-disubstituted pyridines.
abstract: A synthetic strategy to access 2,6-disubstituted pyridines from triazolopyridines through a regioselective nickel-catalyzed alkenylation reaction of the C7-H bond is described. The N2 fragment embedded in the resulting C-H functionalized triazolopyridine can be readily excised using acidic or oxidative conditions to unmask the pyridine.
authors: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607-7061, United States.
authors: Sheng
authors: S
authors: Liu
authors: James
authors: J
authors: Sawicki
authors: Tom G
authors: TG
authors: Driver
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011725:Pyridines; D014230:Triazoles; D009532:Nickel