title: Chitosan/halloysite nanotubes bionanocomposites: structure, mechanical properties and biocompatibility.
abstract: Incorporation of nanosized reinforcements into chitosan usually results in improved properties and changed microstructures. Naturally occurred halloysite nanotubes (HNTs) are incorporated into chitosan for forming bionanocomposite films via solution casting. The electrostatic attraction and hydrogen bonding interactions between HNTs and chitosan are confirmed. HNTs are uniformly dispersed in chitosan matrix. The tensile strength and Young's modulus of chitosan are enhanced by HNTs. The storage modulus and glass transition temperature of chitosan/HNTs films also increase significantly. Blending with HNTs induces changes in surface nanotopography and increase of roughness of chitosan films. In vitro fibroblasts response demonstrates that both chitosan and chitosan/HNTs nanocomposite films are cytocompatibility even when the loading of HNTs is 10%. In summary, these results provide insights into understanding of the structural relationships of chitosan/HNTs bionanocomposite films in potential applications, such as scaffold materials in tissue engineering.
authors: Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China.
authors: Mingxian
authors: M
authors: Liu
authors: Yun
authors: Y
authors: Zhang
authors: Chongchao
authors: C
authors: Wu
authors: Sheng
authors: S
authors: Xiong
authors: Changren
authors: C
authors: Zhou
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D000077215:Clay; D004337:Drug Carriers / Q000737:chemistry / Q000633:toxicity; D055595:Mechanical Phenomena; D051379:Mice; D041681:NIH 3T3 Cells; D053761:Nanocomposites / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D000538:Aluminum Silicates; D001672:Biocompatible Materials; D004337:Drug Carriers; D048271:Chitosan; D000077215:Clay