title: Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver.
abstract: Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver.
authors: Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro (CH), Italy.
authors: Claudia
authors: C
authors: Cicione
authors: Chiara
authors: C
authors: Degirolamo
authors: Antonio
authors: A
authors: Moschetta
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D001647:Bile Acids and Salts; C117476:FGF19 protein, human; C108526:fibroblast growth factor 15, mouse; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D005947:Glucose