title: Do sequential EEG changes predict atypical clinical features in rolandic epilepsy?
abstract: OBJECTIVE
  Although the prognosis for rolandic epilepsy is regarded to be favourable, a small proportion of cases that initially present as rolandic epilepsy evolve into atypical benign partial epilepsy (ABPE) of childhood. The purpose of our study was to determine electroencephalogram (EEG) criteria in relation to atypical seizure manifestations, and cognitive and behavioural problems in rolandic epilepsy.
  
  
  METHODS
  The rolandic epilepsy group consisted of 10 children (mean age 5y 6mo, SD 1y 1mo, median age 5y 5mo; six males, four females). The ABPE group comprised five children (mean age 5y, SD 1y 2mo, median age 4y 5mo; three males, two females). We recorded the number of spikes, the locations of spikes, and the duration of the spike activity. The Wechsler Intelligence Scale for Children-Third Edition or the Wechsler Preschool and Primary Scale of Intelligence, depending on age, was administered to all children at the onset of seizures and every year thereafter. The diagnosis of attention-deficit-hyperactivity disorder was made according to the DSM-IV.
  
  
  RESULTS
  Significant correlations were found between atypical clinical features and extended periods of high-frequency paroxysmal EEG abnormalities (>24mo after onset; p<0.01) and frontal EEG focus (>10mo after onset; p<0.003).
  
  
  CONCLUSIONS
  A combination of spike rate and extended periods of high-frequency paroxysmal EEG abnormalities may predict the evolution of atypical rolandic epilepsy.
authors: Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors: Hideaki
authors: H
authors: Kanemura
authors: Fumikazu
authors: F
authors: Sano
authors: Kakuro
authors: K
authors: Aoyagi
authors: Kanji
authors: K
authors: Sugita
authors: Masao
authors: M
authors: Aihara
mesh_terms: D000200:Action Potentials; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis*; D015897:Comorbidity; D018450:Disease Progression; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis*; D019305:Epilepsy, Rolandic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011594:Psychometrics; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted; D014888:Wechsler Scales / Q000706:statistics & numerical data