title: New serratene triterpenoids from Palhinhaea cernua and their cytotoxic activity.
abstract: Four new serratene triterpenoids, 3β,21β,24-trihydroxyserrat-14-en-24-(4'-hydroxybenzoate) (1), 3β,21α,24-trihydroxyserrat-14-en-3-(4'-hydroxybenzoate) (2), 3β,14α,15α,21α-tetrahydroxyserrat-14-en-3-(3'-methoxyl-4'-hydroxybenzoate) (3), and 3β,14α,15α,21α-tetrahydroxyserrat-14-en-21-acetyl-3-(4'-hydroxybenzoate) (4), together with two known ones, 5 and 6, were isolated from whole plants of Palhinhaea cernua. The structures of these new compounds were elucidated by spectroscopic methods. All the six compounds were tested for their in vitro cytotoxicity against three human cancer cell lines (K562, SMMC-7721, and SGC7901). Compound 5 showed cytotoxicity against the three test cell lines with IC₅₀ values of 20.3, 34.0, and 22.5 ug/mL, respectively. Compound 1 showed slight cytotoxicity against K562 cell lines with IC₅₀ value of 56.1 ug/mL, while no obvious inhibitory effects were detected for other compounds.
authors: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
authors: Jian
authors: J
authors: Yan
authors: Zhong-Yu
authors: ZY
authors: Zhou
authors: Mei
authors: M
authors: Zhang
authors: Jing
authors: J
authors: Wang
authors: Hao-Fu
authors: HF
authors: Dai
authors: Jian-Wen
authors: JW
authors: Tan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D003603:Cytotoxins / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D029542:Lycopodiaceae / Q000737:chemistry*; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C578357:3beta,21beta,24-trihydroxyserrat-14-en; D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D014315:Triterpenes