title: Basal, circadian, and acute inflammation in normal versus overweight men.
abstract: Increased inflammation is present in obese compared with normal weight individuals, but inflammation characteristics of nonobese, overweight individuals are less clear.
  
  
  OBJECTIVE
  The objective of this study was to determine whether basal, circadian, and posteccentric exercise inflammation levels differ between normal and overweight men.
  
  
  METHODS
  Men (18-35 yr old) classified as normal weight (body mass index ≤25 kg·m, n = 20) and overweight (body mass index = 25-30 kg·m, n = 10) completed exercise (EX) and control (CON) conditions in random order. Maximal voluntary effort and eccentric actions (3 × 15) using the elbow flexor muscles of one arm were performed, and blood was collected preexercise and 4, 8, 12, and 24 h postexercise at 7:00 a.m., 12:00 p.m., 4:00 p.m., 8:00 p.m., and 7:00 a.m. Blood was collected on a time-matched schedule without exercise for CON. Soluble tumor necrosis factor receptor-1, interleukin-6, C-reactive protein (CRP), and cortisol responses (EX value - time-matched CON value) were measured.
  
  
  RESULTS
  Basal CRP was higher in the overweight compared with normal weight group (mean ± SD, 0.542 ± 0.578 vs 1.395 ± 1.041 mg·L). Soluble tumor necrosis factor receptor-1 increased (P < 0.05) 8 h postexercise in both groups, and the response was greater 12 and 24 h postexercise in the overweight compared with normal weight groups. Interleukin-6 increased (P < 0.05) 8 h postexercise, with a trend (P = 0.09) to be greater in the overweight group. CRP and cortisol responses were not detected.
  
  
  CONCLUSIONS
  The low-grade inflammation state in overweight compared with normal weight men includes both higher basal CRP concentrations and enhanced acute inflammation, but not in changes to the circadian patterns of cortisol and inflammation variables.
authors: Department of Health and Human Development, Montana State University, Bozeman, MT 59717, USA. mmiles@montana.edu
authors: Mary P
authors: MP
authors: Miles
authors: Jan M
authors: JM
authors: Keller
authors: Lindsay K
authors: LK
authors: Kordick
authors: Jessy R
authors: JR
authors: Kidd
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002940:Circadian Rhythm / Q000502:physiology*; D015444:Exercise / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries; D050177:Overweight / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D006854:Hydrocortisone