title: Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment.
abstract: The objective of this study was to evaluate the correlation between cyclooxygenase-2 (COX-2) and markers of cell proliferation and apoptosis, including, Bcl-2, Bax, Ki-67 and the type I insulin-like growth factor (IGF) receptor (IGF1-R) in ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma (IDC), present in the same surgical specimen. A total of 110 cases were evaluated using tissue microarrays. Cases were classified in scores from 0 to 3 according to pre-defined methods. The results showed that the positivity rates were COX-2 in 87% of cases in DCIS and IDC; Bcl-2 in 55% of cases in DCIS and IDC; Bax in 23% of cases in IDC and 19% in DCIS, IGF-1 in 24% of cases in DCIS and IDC; and Ki-67 in 81% of cases in DCIS and IDC. We also observed a positive correlation between the expression of COX-2 and IGF1-R (p=0.045). Our results demonstrate a positive correlation between the expression of COX-2 and IGF1-R in DCIS and IDC, demonstrating that they are involved in breast cancer carcinogenesis. Further studies are required to prove the effectiveness of COX-2 and IGF1-R inhibitors for the prevention and treatment of breast cancer, as well as to explain their mechanism of action.
authors: Department of Obstetrics and Gynecology, Irmandade da Santa Casa de Misericórdia de São Paulo and Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, Brazil.
authors: Giuliana Cássia Morrone
authors: GC
authors: Taromaru
authors: Vilmar Marques
authors: VM
authors: DE Oliveira
authors: Maria Antonieta Longo Galvão
authors: MA
authors: Silva
authors: Wagner Ricardo
authors: WR
authors: Montor
authors: Fabio
authors: F
authors: Bagnoli
authors: José Francisco
authors: JF
authors: Rinaldi
authors: Tsutomu
authors: T
authors: Aoki