title: Determination of relative in vivo osteoconductivity of modified potassium fluorrichterite glass-ceramics compared with 45S5 bioglass.
abstract: Potassium fluorrichterite (KNaCaMg(5)Si(8)O(22)F(2)) glass-ceramics were modified by either increasing the concentration of calcium (GC5) or by the addition of P(2)O(5) (GP2). Rods (2 × 4 mm) of stoichiometric fluorrichterite (GST), modified compositions (GC5 and GP2) and 45S5 bioglass, which was used as the reference material, were prepared using a conventional lost-wax technique. Osteoconductivity was investigated by implantation into healing defects in the midshaft of rabbit femora. Specimens were harvested at 4 and 12 weeks following implantation and tissue response was investigated using computed microtomography (μCT) and histological analyses. The results showed greatest bone to implant contact in the 45S5 bioglass reference material at 4 and 12 weeks following implantation, however, GST, GC5 and GP2 all showed direct bone tissue contact with evidence of new bone formation and cell proliferation along the implant surface into the medullary space. There was no evidence of bone necrosis or fibrous tissue encapsulation around the test specimens. Of the modified potassium fluorrichterite compositions, GP2 showed the greatest promise as a bone substitute material due to its osteoconductive potential and superior mechanical properties.
authors: Centre for Biomaterials and Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA, UK. shash12@yahoo.com
authors: Shashwat
authors: S
authors: Bhakta
authors: Paulo E
authors: PE
authors: Faira
authors: Luiz A
authors: LA
authors: Salata
authors: Patricio Jose
authors: PJ
authors: de Oliveira Neto
authors: Cheryl A
authors: CA
authors: Miller
authors: Richard
authors: R
authors: van Noort
authors: Ian M
authors: IM
authors: Reaney
authors: Ian M
authors: IM
authors: Brook
authors: Paul V
authors: PV
authors: Hatton
mesh_terms: D000818:Animals; D002516:Ceramics / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D017633:Magnesium Silicates / Q000737:chemistry*; D008297:Male; D011817:Rabbits; D014057:Tomography, X-Ray Computed
chemical_list: D017633:Magnesium Silicates; C425330:bioactive glass 45S5; C454689:fluorrichterite