title: SOX40L: an important inflammatory mediator in adult bronchial asthma.
abstract: BACKGROUND
  The role of soluble OX40 ligand (sOX40L) in adult bronchial asthma is unclear. This study aims to determine the serum concentrations of sOX40L in adult patients with bronchial asthma, and discussed its relationship with pulmonary function.
  
  
  METHODS
  We measured the pulmonary function using the spirometer and detected the serum concentrations of sOX40L by enzyme linked immunosorbent assay (ELISA) in 19 healthy persons in the control group, 58 acute asthmatic adult patients who were grouped according to their disease severity: 18 mild grade, 24 moderate grade, 16 severe grade, and 24 persons in a stable asthmatic group.
  
  
  RESULTS
  The serum concentrations of sOX40L in asthmatic adult patients (6.80 ± 4.95 ng/L) were distinctly higher than those in the control group (3.98 ± 2.83 ng/L, P <0.05), and they were negatively correlated with pulmonary function indexes (FEV1%, FVC%, FEV1/FVC) (r = -0.754, P <0.01, r = -0.557, P <0.01, r = -0.457, P <0.01, respectively). Moreover, the serum concentrations of sOX40L showed obvious differences among control, mild, moderate, and severe groups (3.98 ± 2.83, 4.87 ± 1.89, 6.97 ± 5.91, 8.71 ± 5.18 ng/L, respectively; P <0.01). The concentrations of sOX40L decreased to the same extent as the control group after therapeutic treatments were provided to the asthmatic adult patients.
  
  
  CONCLUSIONS
  The concentrations of sOX40L were found to be high in adult asthmatic patients and were associated with the severity of the disease. Therefore, sOX40L could be a potential inflammatory mediator in the pathogenesis of asthma.
authors: Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors: Wei
authors: W
authors: Lei
authors: Can Hong
authors: CH
authors: Zhu
authors: Da Xiong
authors: da X
authors: Zeng
authors: Qin
authors: Q
authors: Wang
authors: Xiu Qin
authors: XQ
authors: Zhang
authors: Yan Bin
authors: YB
authors: Chen
authors: Chuan Yong
authors: CY
authors: Mu
authors: Jian An
authors: JA
authors: Huang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000097:blood*; D012720:Severity of Illness Index; D013147:Spirometry
chemical_list: D018836:Inflammation Mediators; D053278:OX40 Ligand