title: Peroxidase-mimic bismuth-gold nanoparticles for determining the activity of thrombin and drug screening.
abstract: Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening.
authors: Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.
authors: Chia-Wen
authors: CW
authors: Lien
authors: Chih-Ching
authors: CC
authors: Huang
authors: Huan-Tsung
authors: HT
authors: Chang
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D001729:Bismuth / Q000737:chemistry* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006046:Gold / Q000737:chemistry* / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D010078:Oxazines / Q000737:chemistry; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000737:chemistry / Q000378:metabolism*; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D010078:Oxazines; C470430:Amplex Red; D006046:Gold; D006861:Hydrogen Peroxide; D009195:Peroxidase; D013917:Thrombin; D001729:Bismuth