title: Engineering hematopoietic stem cells to create melanoma specific CTL.
abstract: Using a humanized mouse model, we developed melanoma specific CD8 T cells from genetically modified human hematopoietic stem cells (hHSC). The transgenic T cells were functional both in vivo and ex vivo, effectively limiting and clearing tumor growth. Finally, the transduced hHSC stably populated the bone marrow.
authors: Department of Medicine; Division of Hematology-Oncology; UCLA AIDS Institute; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA; David Geffen School of Medicine at UCLA; Los Angeles, CA USA.
authors: Dimitrios
authors: D
authors: Vatakis