title: Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats.
abstract: BACKGROUND
  The objective of this study was to determine the early echocardiographic predictors of elevated left ventricular end-diastolic pressure (LVEDP) after a long follow-up period in the infarcted rat model.
  
  
  METHODS
  Five days and three months after surgery, sham and infarcted animals were subjected to transthoracic echocardiography. Regression analysis and receiver-operating characteristic (ROC) curve were performed for predicting increased LVEDP 3 months after MI.
  
  
  RESULTS
  Among all of the variables, assessed 5 days after myocardial infarction, infarct size (OR: 0.760; CI 95% 0.563-0.900; p=0.005), end-systolic area (ESA) (OR: 0.761; CI 95% 0.564-0.900; p=0.008), fractional area change (FAC) (OR: 0.771; CI 95% 0.574-0.907; p=0.003), and posterior wall-shortening velocity (PWSV) (OR: 0.703; CI 95% 0.502-0.860; p=0.048) were predictors of increased LVEDP. The LVEDP was 3.6±1.8 mmHg in the control group and 9.4±7.8 mmHg among the infarcted animals (p=0.007). Considering the critical value of predictor variables in inducing cardiac dysfunction, the cut-off value was 35% for infarct size, 0.33 cm2 for ESA, 40% for FAC, and 26 mm/s for PWSV.
  
  
  CONCLUSIONS
  Infarct size, FAC, ESA, and PWSV, assessed five days after myocardial infarction, can be used to estimate an increased LVEDP three months following the coronary occlusion.
authors: Department of Internal Medicine, Botucatu Medical School, UNESP, Botucatu, Brazil.
authors: Paula S
authors: PS
authors: Azevedo
authors: Bertha F
authors: BF
authors: Polegato
authors: Marcos F
authors: MF
authors: Minicucci
authors: Stephan M
authors: SM
authors: Pio
authors: Igor A
authors: IA
authors: Silva
authors: Priscila P
authors: PP
authors: Santos
authors: Katashi
authors: K
authors: Okoshi
authors: Sergio A R
authors: SA
authors: Paiva
authors: Leonardo A M
authors: LA
authors: Zornoff
mesh_terms: D000818:Animals; D003971:Diastole / Q000502:physiology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D012372:ROC Curve; D051381:Rats; D013997:Time Factors; D014463:Ultrasonography; D017725:Ventricular Pressure / Q000502:physiology*