title: Design, synthesis and vasodilative activity of tanshinone IIA derivatives.
abstract: A new series of tanshinone IIA (DIIA) derivatives were synthesized through the reaction of brominated tanshinone IIA (1-Br DIIA) and aromatic acids in the presence of K(2)CO(3). Twenty compounds were synthesized, and all of them were novel. Vasodilative activities for synthesized compounds were valuated in vitro on the contractile response of vascular thoracic aorta smooth muscle from Wistar rats. The results showed that most compounds exhibited a concentration-dependent inhibition on the contractile response of norepinephrine. Four prepared compounds, 4, 5, 8 and 13 revealed relatively remarkable vasodilative activity.
authors: School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, PR China.
authors: Yue-Feng
authors: YF
authors: Bi
authors: Zhen-Ji
authors: ZJ
authors: Wang
authors: Ruo-Fei
authors: RF
authors: Guan
authors: Yu-Ting
authors: YT
authors: Ye
authors: Yuan-Yuan
authors: YY
authors: Chen
authors: Yan-Bing
authors: YB
authors: Zhang
authors: Hong-Min
authors: HM
authors: Liu
mesh_terms: D045784:Abietanes / Q000737:chemistry*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D015195:Drug Design; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D045784:Abietanes; D014665:Vasodilator Agents; C021751:tanshinone; D009638:Norepinephrine