title: Reconstruction of a large osteochondral lesion of the distal tibia with an iliac crest graft and autologous matrix-induced chondrogenesis (AMIC): a case report.
abstract: Isolated osteochondral lesions (OCL) of the distal tibia are rare and lack clear treatment guidelines. With the case we present here, we suggest a novel surgical approach and report the successful use of autologous matrix-induced chondrogenesis-aided reconstruction for OCL of the distal tibia. A 29-year-old male patient complained about persisting pain of the left ankle joint and a restricted activity level 12 months after an ankle sprain. Imaging revealed edema of the subchondral bone and thinning of the cartilage above the osseous defect at the lateral distal tibia. The OCL was debrided followed by microfracturing of the underlying sclerotic bone. A cancellous bone plug was harvested from the iliac crest and impacted into the defect. A collagen matrix was then fixed on the defect. After 12 months, the patient was free of pain and returned to full activity. Conventional radiographs at 1 year showed successful osseous integration of the plug and a nearly anatomic shape of the tibial joint line. Delayed gadolinium-enhanced MRI of cartilage scans at 36 months showed an intact cartilage layer over the defect and glycosaminoglycan content, indicating hyaline-like cartilage repair. This case demonstrates autologous matrix-induced chondrogenesis-aided reconstruction of large osteochondral lesions of distal tibia to be a promising treatment method. Our aim was to describe the case of a patient with a large isolated osteochondral lesion of the distal tibia treated by a novel operative technique using cancellous bone from the iliac crest and a collagen I/III matrix.
authors: Orthopaedic Department, University Hospital Basel, Basel, Switzerland.
authors: Matthias
authors: M
authors: Miska
authors: Martin
authors: M
authors: Wiewiorski
authors: Victor
authors: V
authors: Valderrabano
mesh_terms: D000328:Adult; D016512:Ankle Injuries / Q000601:surgery*; D020219:Chondrogenesis; D005109:Extracellular Matrix; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008297:Male; D013180:Sprains and Strains / Q000601:surgery*; D013977:Tibia / Q000293:injuries* / Q000601:surgery*; D014182:Transplantation, Autologous