title: Polymorphisms in the melatonin receptor 1B gene and the risk of delirium.
abstract: OBJECTIVE
  A disturbed sleep-wake rhythm cycle can be seen in delirium and as melatonin regulates this cycle via melatonin receptors, genetic variations in these receptors may contribute to susceptibility to delirium. The purpose of this study was to investigate whether genetic variants in the melatonin receptor 1B (MTNR1B) gene are associated with delirium.
  
  
  METHODS
  Elderly medical and hip surgery patients were included in the study. Five single-nucleotide polymorphisms (SNPs) were determined in the MTNR1B gene, i.e. rs18030962, rs3781638, rs10830963, rs156244 and rs4753426.
  
  
  RESULTS
  In total, 53% of 171 hip fracture patients and 33% of 699 medical patients were diagnosed with delirium. None of the polymorphisms were found to be associated with the occurrence of delirium.
  
  
  CONCLUSIONS
  Future research could focus on sequencing this gene to look for other functional SNPs in relation to delirium.
authors: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. a.dejonghe@amc.uva.nl
authors: A
authors: A
authors: de Jonghe
authors: S
authors: S
authors: de Rooij
authors: M W T
authors: MW
authors: Tanck
authors: E J G
authors: EJ
authors: Sijbrands
authors: B C V
authors: BC
authors: van Munster
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003693:Delirium / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044122:Receptor, Melatonin, MT1 / Q000235:genetics*; D044123:Receptor, Melatonin, MT2; D012307:Risk Factors
chemical_list: C573871:MTNR1B protein, human; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2