title: Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats.
abstract: The inhibitor κB protein kinase/nuclear factor κB (IKK/NF-κB) signaling pathway is critical for synaptic plasticity. However, the role of IKK/NF-κB in drug withdrawal-associated conditioned place aversion (CPA) memory is unknown. Here, we showed that inhibition of IKK/NF-κB by sulphasalazine (SSZ; 10 mM, i.c.v.) selectively blocked the extinction but not acquisition or expression of morphine-induced CPA in rats. The blockade of CPA extinction induced by SSZ was abolished by sodium butyrate, an inhibitor of histone deacetylase. Thus, the IKK/NF-κB signaling pathway might play a critical role in the extinction of morphine-induced CPA in rats and might be a potential pharmacotherapy target for opiate addiction.
authors: Tianjin Medical University, Tianjin, China.
authors: Cheng-Hao
authors: CH
authors: Yang
authors: Xiang-Ming
authors: XM
authors: Liu
authors: Ji-Jian
authors: JJ
authors: Si
authors: Hai-Shui
authors: HS
authors: Shi
authors: Yan-Xue
authors: YX
authors: Xue
authors: Jian-Feng
authors: JF
authors: Liu
authors: Yi-Xiao
authors: YX
authors: Luo
authors: Chen
authors: C
authors: Chen
authors: Peng
authors: P
authors: Li
authors: Jian-Li
authors: JL
authors: Yang
authors: Ping
authors: P
authors: Wu
authors: Lin
authors: L
authors: Lu
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D003214:Conditioning, Classical; D051550:I-kappa B Kinase / Q000378:metabolism*; D007276:Injections, Intraventricular; D008568:Memory; D009020:Morphine / Q000009:adverse effects; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013375:Substance Withdrawal Syndrome; D012460:Sulfasalazine / Q000008:administration & dosage
chemical_list: D016328:NF-kappa B; D012460:Sulfasalazine; D009020:Morphine; D051550:I-kappa B Kinase