title: Gastric mixed adenoneuroendocrine carcinoma with a trilineage cell differentiation: case report and review of the literature.
abstract: Most gastric neuroendocrine tumours are well differentiated and considered as neuroendocrine neoplasms, whilst poorly differentiated lesions are considered as neuroendocrine carcinomas and account for only 6-16% of gastric neuroendocrine tumours. Gastric mixed adenoneuroendocrine carcinomas are rare malignancies usually composed of a neuroendocrine carcinoma and an adenocarcinoma with a variable grade of differentiation. Here, we report an unusual and rare gastric mixed adenoneuroendocrine carcinoma with a trilineage cell differentiation including a neuroendocrine carcinoma, an adenocarcinoma and a squamous cell carcinoma. A brief discussion of the histopathological features, biological behaviour and treatment of this rare tumour type is presented.
authors: Department of Neuroendocrine Tumours, European Center of Excellence, Royal Free Hospital, London, UK.
authors: Marinos
authors: M
authors: Pericleous
authors: Christos
authors: C
authors: Toumpanakis
authors: Heather
authors: H
authors: Lumgair
authors: Martyn E
authors: ME
authors: Caplin
authors: Luke
authors: L
authors: Morgan-Rowe
authors: Ian
authors: I
authors: Clark
authors: Tu Vinh
authors: TV
authors: Luong