title: p-Cymene protects mice against lipopolysaccharide-induced acute lung injury by inhibiting inflammatory cell activation.
abstract: The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.
authors: College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China.
authors: Guanghong
authors: G
authors: Xie
authors: Na
authors: N
authors: Chen
authors: Lanan Wassy
authors: LW
authors: Soromou
authors: Fang
authors: F
authors: Liu
authors: Ying
authors: Y
authors: Xiong
authors: Qianchao
authors: Q
authors: Wu
authors: Hongyu
authors: H
authors: Li
authors: Haihua
authors: H
authors: Feng
authors: Guowen
authors: G
authors: Liu
mesh_terms: D055371:Acute Lung Injury / Q000201:enzymology / Q000473:pathology* / Q000517:prevention & control*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D000081007:Cymenes; D016207:Cytokines / Q000378:metabolism; D007249:Inflammation / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D020935:MAP Kinase Signaling System / Q000187:drug effects; D051379:Mice; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D014867:Water
chemical_list: D000081007:Cymenes; D016207:Cytokines; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D039821:Monoterpenes; D016328:NF-kappa B; D020011:Protective Agents; D014867:Water; C007210:4-cymene; D009195:Peroxidase; D020928:Mitogen-Activated Protein Kinases