title: Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles.
abstract: A new class of sulfone linked bis heterocycles viz., pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazoles were prepared and tested for antimicrobial activity and cytotoxicity. The chloro-substituted compounds 5c, 8c and 14c showed comparable antibacterial activity to chloramphenicol against Pseudomonasaeruginosa and compound 5c exhibited comparable antifungal activity to ketoconazole against Penicilliumchrysogenum. One of the compounds, vinylsulfonyl oxadiazole showed appreciably cytotoxic activity on A549 lung carcinoma cells with an IC(50) at a concentration of 31.7 μM.
authors: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors: A
authors: A
authors: Muralikrishna
authors: B C
authors: BC
authors: Venkatesh
authors: V
authors: V
authors: Padmavathi
authors: A
authors: A
authors: Padmaja
authors: P
authors: P
authors: Kondaiah
authors: N Siva
authors: NS
authors: Krishna
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D006571:Heterocyclic Compounds; D013450:Sulfones