title: From cancer genomes to oncogenic  drivers, tumour dependencies and  therapeutic targets.
abstract: The analysis of human cancer by genome sequencing and various types of arrays has proved that many tumours harbour hundreds of genes that are mutated or substantially altered by copy number changes. But how many of these changes are meaningful? And how can we exploit these massive data sets to yield new targets for cancer treatment? In this Opinion article, we describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.
authors: Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, New York 11797, USA.
authors: Cheryl
authors: C
authors: Eifert
authors: R Scott
authors: RS
authors: Powers
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D016678:Genome; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy