title: Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk.
abstract: OBJECTIVE
  To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake.
  
  
  METHODS
  Two prospective cohort studies and a case-control study.
  
  
  METHODS
  Academic institution.
  
  
  METHODS
  A total of 992 cases and 1,050 population-based control samples from a New England case-control study and 240 cases and 900 control samples from the Nurses' Health Studies.
  
  
  METHODS
  None.
  
  
  METHODS
  Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT with the use of the Taqman 5' nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2).
  
  
  RESULTS
  Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled risk ratio 1.1 [95% confidence interval (CI) 0.8-1.5] for D1 and 1.0 [95% CI 0.7-1.4] for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake.
  
  
  CONCLUSIONS
  D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.
authors: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. merritt@jimmy.harvard.edu
authors: Melissa A
authors: MA
authors: Merritt
authors: Joanne
authors: J
authors: Kotsopoulos
authors: Daniel W
authors: DW
authors: Cramer
authors: Susan E
authors: SE
authors: Hankinson
authors: Kathryn L
authors: KL
authors: Terry
authors: Shelley S
authors: SS
authors: Tworoger
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*; D011446:Prospective Studies; D012306:Risk; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000235:genetics*
chemical_list: D005694:UTP-Hexose-1-Phosphate Uridylyltransferase