title: Asymmetric hydroalkynylation of norbornadienes promoted by chiral iridium catalysts.
abstract: Across bonds: The first successful iridium-catalyzed asymmetric hydroalkynylation of nonpolar alkenes with good to excellent enantioselectivity is described (see scheme; cod = 1,5-cyclooctadiene, DCE = 1,2-dichloroethane). This catalytic system exhibits good functional group compatibility as NH(2), OH, Br, F, and SiMe(3) groups remain intact during the reaction.
authors: Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming, 650500, China. adams.bmf@hotmail.com
authors: Bao-Min
authors: BM
authors: Fan
authors: Qing-jing
authors: QJ
authors: Yang
authors: Jun
authors: J
authors: Hu
authors: Cai-ling
authors: CL
authors: Fan
authors: Si-feng
authors: SF
authors: Li
authors: Lu
authors: L
authors: Yu
authors: Chao
authors: C
authors: Huang
authors: Wing Wai
authors: WW
authors: Tsang
authors: Fuk Yee
authors: FY
authors: Kwong
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009636:Norbornanes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001952:Bridged-Ring Compounds; D009636:Norbornanes; D009942:Organometallic Compounds; D007495:Iridium