title: Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence.
abstract: BACKGROUND
  Malaria continues to represent a huge global health burden on the most vulnerable populations. The Intermittent Preventive Treatment (IPT) strategy has been shown to be an efficacious intervention in preventing most of the deleterious effects of malaria in pregnant women and infants. Yet, the effectiveness of the IPT strategy may be impaired by the increasing resistance to sulfadoxine-pyrimethamine (SP), and the scarcity of alternative antimalarial drugs.
  
  
  METHODS
  This review examines all the available information on IPT, in an aim to provide the scientific community with a framework to understand the benefits and limitations of this malaria control strategy. It includes the understanding of the historical background of the IPT strategy, the drug's mechanisms of actions, updated information on current available evidence, the implications of drug resistance and choice of alternative drugs, and a comprehensive discussion on the perspectives of IPT for malaria control in pregnant women and infants.
  
  
  CONCLUSIONS
  IPT in pregnancy and infants is a cost-effective strategy that can contribute significantly to the control of malaria in endemic areas. Monitoring its effectiveness will allow tracking of progress, evaluation of the adequacy of currently used drugs and will highlight the eventual need for new therapies or alternative interventions.
authors: University of Barcelona, Hospital Clínic, Barcelona Centre for International Health Research, Roselló, 132, 08036, Barcelona, Spain. abardaji@clinic.ub.es
authors: Azucena
authors: A
authors: Bardají
authors: Quique
authors: Q
authors: Bassat
authors: Pedro L
authors: PL
authors: Alonso
authors: Clara
authors: C
authors: Menéndez
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage* / Q000191:economics; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000191:economics / Q000276:immunology / Q000517:prevention & control*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000517:prevention & control*
chemical_list: D000962:Antimalarials