title: Case report of atopic dermatitis with refractory pruritus markedly improved with the novel use of clonidine and trimeprazine.
abstract: We report a 6-year-old boy with severe atopic dermatitis and refractory pruritus. The novel use of clonidine, an adrenergic agonist, along with trimeprazine, led to dramatic improvement. This represents the first case report of clonidine's effect in relieving pruritus in atopic dermatitis.
authors: Faculty of MedicineDepartments of AnesthesiaServices of Allergy and ImmunologyPediatricsDermatology, CHU Sainte JustineDepartment of Nursing, University of Montreal, Montreal, Quebec, Canada.
authors: Annie
authors: A
authors: Genois
authors: Margaret
authors: M
authors: Haig
authors: Anne
authors: A
authors: Des Roches
authors: Alain
authors: A
authors: Sirard
authors: Sylvie
authors: S
authors: Le May
authors: Catherine C
authors: CC
authors: McCuaig
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use; D002648:Child; D003000:Clonidine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D056687:Off-Label Use; D011537:Pruritus / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014291:Trimeprazine / Q000627:therapeutic use*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000982:Antipruritics; D014291:Trimeprazine; D003000:Clonidine