title: Efficacy of sublingual swallow immunotherapy in children with rye grass pollen allergic rhinitis: a double-blind placebo-controlled study.
abstract: Specific local immunotherapy has been recently introduced as an alternative to classic subcutaneous immunotherapy in treatment of allergic rhinitis. In this study, the effects of sublingual immunotherapy (SLIT) on symptoms and medication score and skin prick test evaluation of patients with allergic rhinitis were investigated.In this placebo controlled trial, twenty four patients aged 5-18 years old with grass pollen induced rhinitis and sensitive to rye grass by positive skin prick test received randomly sublingual extract of rye grass or placebo for 6 months. Symptom and medication scores and adverse effects of SLIT were assessed during treatment. Skin prick test induced wheal at the beginning and the end of therapy were also measured. Data were analyzed with SPSS software.We found significant reduction of symptoms in intervention group from 21st week of immunotherapy (p<0.05). Medication scores were also reduced after 16th week (p<0.05), adverse effects were low and insignificant in both groups. Erythema induced diameter with skin prick test for grass and rye grass was significantly reduced in SLI group after immunotherapy.This study indicates that SLIT in grass-pollen rhinitis is well tolerated, improves overall clinical symptoms, and reduces drug consumes. We recommend this therapy as a safe therapy in patients with allergic rhinitis.
authors: Department of Pediatrics, Sub-specialist in Immunology and Allergy, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran. akefeh45@zums.ac.ir
authors: Akefeh
authors: A
authors: Ahmadiafshar
authors: Mina
authors: M
authors: Maarefvand
authors: Babak
authors: B
authors: Taymourzade
authors: Saeedeh
authors: S
authors: Mazloomzadeh
authors: Zohreh
authors: Z
authors: Torabi
mesh_terms: D000286:Administration, Sublingual; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000336:Aerosols; D052179:Antigens, Plant / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007428:Intradermal Tests; D008129:Lolium / Q000276:immunology*; D008297:Male; D010940:Plant Proteins / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists; D000336:Aerosols; D052179:Antigens, Plant; D006633:Histamine Antagonists; D010940:Plant Proteins