title: Versatility of the translational machinery during stress: changing partners to keep dancing.
abstract: Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5' end of mRNAs. During hypoxic stress, global translation decreases because eIF4E is inactivated. In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.
authors: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG-UPF), Dr Aiguader 88, 08003-Barcelona, Spain. fatima.gebauer@crg.eu
authors: Fátima
authors: F
authors: Gebauer
mesh_terms: D020413:3' Untranslated Regions; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D015687:Cell Hypoxia; D002460:Cell Line; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010442:Peptide Chain Initiation, Translational; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D020413:3' Untranslated Regions; D051792:Basic Helix-Loop-Helix Proteins; D066246:ErbB Receptors; D039561:Eukaryotic Initiation Factor-4E; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1; C473692:RBM4 protein, human