title: Clinical significance of incidental colonic 18F-FDG uptake on PET/CT images in patients with gastric adenocarcinoma.
abstract: OBJECTIVE
  We assessed the ability of positron emission tomography-computed tomography (PET/CT) to detect synchronous colonic pathology and determined the significance of 18F-fluorodeoxyglucose (18F-FDG) activity in the colon of gastric cancer patients.
  
  
  METHODS
  A total of 239 gastric cancer patients who underwent PET/CT and colonoscopy preoperatively were included. FDG uptake patterns on PET/CT were classified as (1) group A, focal; (2) group B, diffuse; and (3) group C, no uptake. The PET/CT findings were compared with the results of concurrent colonoscopy.
  
  
  RESULTS
  In group A, a total of 123 polyps of >0 mm were observed. Of these, nine polyps were colonic adenocarcinomas and six were high-grade dysplasia. The incidence of colonic adenocarcinomas was significantly higher in group A than in the other two groups (p = 0.037). There was a significant correlation between SUVmax values and incidence of colonic polyps of >10 mm (r = 0.471, p = 0.04). The distribution pattern of SUVmax in polyps with adenoma (>10 mm) was less homogenous than in polyps (>10 mm) with adenocarcinoma.
  
  
  CONCLUSIONS
  The focal colonic FDG uptake in PET/CT requires colonoscopic confirmation. The suspicion of colonic malignancy increased in the presence of polyps >10 mm that showed a positive correlation with the SUVmax.
authors: Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, South Korea.
authors: Jung Ho
authors: JH
authors: Shim
authors: Joo Hyun
authors: JH
authors: O
authors: Seong Il
authors: SI
authors: Oh
authors: Han Mo
authors: HM
authors: Yoo
authors: Hae Myung
authors: HM
authors: Jeon
authors: Cho Hyun
authors: CH
authors: Park
authors: Sung Hoon
authors: SH
authors: Kim
authors: Kyo Young
authors: KY
authors: Song
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000236:Adenoma / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003111:Colonic Polyps / Q000000981:diagnostic imaging / Q000473:pathology; D003113:Colonoscopy; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging*; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18