title: Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice.
abstract: The present study investigated the gastroprotective effects of a cinnamon diet using different gastric ulcer mouse models. Dose dependency and the effective dose period of administration of a cinnamon powder diet were established using the water immersion stress gastric ulcer model. A cinnamon powder diet significantly protected mice against ulceration by stress, ethanol, HCl and oral administration of aspirin, but not against ulceration by oral administration of indomethacin or subcutaneous administration of indomethacin or aspirin. Such a diet conferred protection against gastric ulcers at an effective concentration of 100 mg cinnamon powder per gram of food after administration for 4 weeks and the active compound of cinnamon powder for gastroprotective activity was identified as cinnamaldehyde. These findings indicate that regular ingestion of cinnamon powder offers gastroprotection presumably through a cytoprotective mechanism but the efficacy against NSAIDs-induced gastric ulcers may be limited.
authors: Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Kyoto University, 46-29, Kyoto, 606-8501, Japan.
authors: Joan Manjuh
authors: JM
authors: Tankam
authors: Yuki
authors: Y
authors: Sawada
authors: Michiho
authors: M
authors: Ito
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000627:therapeutic use*; D000431:Ethanol / Q000009:adverse effects; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D051379:Mice; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; C532132:cinnamomi cortex; D000431:Ethanol; D000171:Acrolein; D001241:Aspirin; C012843:cinnamaldehyde; D007213:Indomethacin