title: Optimizing cancer treatments to induce an acute immune response: radiation Abscopal effects, PAMPs, and DAMPs.
abstract: Clinical results indicate improved survival in poorly differentiated prostate cancer patients following a treatment schedule that maximizes hormone therapy prior to radiation. This may be because of a systemic immune response, called an abscopal effect. A literature review showed an association between acute infection and abscopal cancer remission. This led to the theory that, in the presence of endogenous cancer-specific antigens exposed by cancer necrosis, an innate immune response can adapt to respond to those antigens via a cross-talk mechanism. This theory was validated in an animal model. An acute innate immune T-cell response was stimulated using cluster vaccination with Poly(I:C). In the presence of exogenous cancer-specific antigens, this immune response became adaptive, creating an abscopal effect that resulted in cancer resolution. These concepts may be of clinical value, improving outcomes by inducing systemic abscopal effects.
authors: Department of Radiation Oncology, Vancouver Island Centre, BC Cancer Agency, Victoria, British Columbia, Canada. cludgate@bccancer.bc.ca
authors: Charles M
authors: CM
authors: Ludgate
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects; D003131:Combined Modality Therapy; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy; D012329:RNA, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D011878:Radiotherapy
chemical_list: D006728:Hormones; D012329:RNA, Bacterial