title: Prospective evaluation of 1-day polyethylene glycol-3350 bowel preparation regimen in children.
abstract: OBJECTIVE
  The aim of the present study was to evaluate efficacy, safety, and tolerability of a pediatric colonoscopy bowel preparation regimen composed of polyethylene glycol-3350 (PEG-3350) and a sports drink completed in a few hours.
  
  
  METHODS
  A prospective, open-label trial of a colonoscopy bowel preparation in children ages 8 to 18 years that included 238 g of PEG-3350 mixed with 1.9 L of Gatorade completed in a few hours. Efficacy was determined using the Boston Bowel Preparation Scale. Basic metabolic profiles and questionnaires were obtained that assessed for safety, adverse effects, tolerability, and patient acceptability.
  
  
  RESULTS
  Forty-six patients completed the study. Patients were predominately boys (56.5%) with a mean age of 14.50 years (SD ± 2.9 years). Forty-three (93.5%) were able to complete the regimen. All of the colonoscopies were completed to the cecum and 84% had terminal ileum visualization. Seventy-seven percent were found to be effective preparations. Nausea/vomiting were the most common reported adverse effect (60%) followed by abdominal pain/cramping (44%) and fatigue/weakness (40%). Overall, the regimen was acceptable with 1 exception being the large volume to drink. There were no clinically significant changes in basic metabolic profiles, although there was a statistically significant decrease in the mean potassium (0.16 mEq/L; P = 0.016), blood urea nitrogen (2.68 mg/dL; P < 0.0001), and carbon dioxide (1.89 mmol/L; P < 0.0001).
  
  
  CONCLUSIONS
  This study demonstrated that PEG-3350 + Gatorade administered in a few hours is an effective, safe, and moderately tolerable bowel preparation regimen for colonoscopy in children.
authors: Department of Pediatrics, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA. mazen.abbas@us.army.mil
authors: Mazen I
authors: MI
authors: Abbas
authors: Cade M
authors: CM
authors: Nylund
authors: Carol J
authors: CJ
authors: Bruch
authors: Luzviminda G
authors: LG
authors: Nazareno
authors: Philip L
authors: PL
authors: Rogers
mesh_terms: D015746:Abdominal Pain; D000293:Adolescent; D001628:Beverages; D001806:Blood Urea Nitrogen; D002245:Carbon Dioxide / Q000097:blood; D002400:Cathartics; D002432:Cecum; D002648:Child; D003106:Colon / Q000601:surgery; D003113:Colonoscopy / Q000379:methods*; D005221:Fatigue; D005260:Female; D006801:Humans; D007082:Ileum; D008297:Male; D009120:Muscle Cramp; D009325:Nausea; D010349:Patient Compliance; D017060:Patient Satisfaction; D011092:Polyethylene Glycols; D011188:Potassium / Q000097:blood; D011446:Prospective Studies; D014839:Vomiting
chemical_list: D002400:Cathartics; D002245:Carbon Dioxide; D011092:Polyethylene Glycols; D011188:Potassium