title: Correlations between serum uric acid level and disease activity, intrathecal inflammation reactivity in patients with multiple sclerosis.
abstract: OBJECTIVE
  To explore the correlations between serum uric acid (UA) levels and the clinical and cerebrospinal fluid (CSF) parameters of multiple sclerosis (MS).
  
  
  METHODS
  The medical reports of 47 MS patients admitted to Peking Union Medical College Hospital during 2008 and 2010 were reviewed. And 49 age- and gender-matched cerebral infarction patients were enrolled as control. The mean serum UA level of the MS patients was compared with that of the control group. The correlations between the UA levels and the clinical parameters including gender, disease duration, relapse rate, and disease disabilities as assessed by the Expanded Disability Status Scale score, were explored. Forty-one patients had CSF examinations. The correlations between the UA levels and the CSF parameters reflecting inflammation and tissue damage, including CSF protein, white blood cell count, oligoclonal band, 24-hour IgG index, and myelin basic protein, were also investigated.
  
  
  RESULTS
  The mean serum UA level in the MS patients was lower than that in the control group (247.75±52.59 µmol/L vs. 277.94±74.33 µmol/L, P=0.025) and inversely correlated with the relapse rate (P=0.049). MS patients with lower serum UA levels tended to have higher white blood cell counts and myelin basic protein level. But there was no correlation between CSF protein levels (r=0.165, P=0.273), white blood cell counts (r=-0.051, P=0.732), IgG index (r=0. 045, P=0.802), or myelin basic protein level (r=-0.248, P=0.145) and the serum UA level, respectively.
  
  
  CONCLUSIONS
  In MS patients, UA levels might partly reflect the extent of disability and inflammation.
authors: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors: Cai-yan
authors: CY
authors: Liu
authors: Yan
authors: Y
authors: Xu
authors: Li-ying
authors: LY
authors: Cui
authors: Bin
authors: B
authors: Peng
authors: Li-zhen
authors: LZ
authors: Zhong
authors: Xing-wang
authors: XW
authors: Chen
authors: Jian-ming
authors: JM
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000134:cerebrospinal fluid*; D018836:Inflammation Mediators / Q000032:analysis / Q000134:cerebrospinal fluid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000378:metabolism; D013131:Spine; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D014527:Uric Acid