title: Transcription regulation by distal enhancers: who's in the loop?
abstract: Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
authors: Department of Cell Biology; Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Ralph
authors: R
authors: Stadhouders
authors: Anita
authors: A
authors: van den Heuvel
authors: Petros
authors: P
authors: Kolovos
authors: Ruud
authors: R
authors: Jorna
authors: Kris
authors: K
authors: Leslie
authors: Frank
authors: F
authors: Grosveld
authors: Eric
authors: E
authors: Soler
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D061805:Transcription Elongation, Genetic; D014158:Transcription, Genetic