title: A review of  olanzapine pamoate.
abstract: BACKGROUND
  Olanzapine long-acting injection (OLAI), or olanzapine pamoate , is one of three second generation (SGA) antipsychotics now available in a long-acting formulation. OLAI is a microcrystalline salt of pamoic acid and olanzapine suspended in an aqueous solution that slowly dissociates into the separate components once injected intramuscularly (im) into gluteal muscle.
  
  
  METHODS
  A systematic search of databases including PubMed, PsychInfo, and Embase was conducted using the keywords. Relevant articles were then hand searched and relevant websites (FDA, EMA, Eli Lilly, and NIH) were also reviewed.
  
  
  CONCLUSIONS
  Efficacy has been demonstrated in the short term and maintenance treatment of schizophrenia with OLAI at doses of 150 - 300 mg every two weeks or 405 mg every four weeks. The overall side effect profile is similar to oral olanzapine. While injection site complications are mild, there is an incidence rate per injection of 0.07 % (incidence rate per patient of 1.4%) of post-injection delirium sedation syndrome (PDSS). This manifests as overdose-like symptoms which necessitates mandatory administration and continuous monitoring of OLAI by health care professionals for the first three hours in a suitable clinical facility. As a consequence, final regulatory approval was delayed and market release and clinical use have been limited.
authors: University of Alberta, Department of Psychiatry, 9942-108 Street, Edmonton, Alberta, T5K 2J5, Canada. pchue@ualberta.ca
authors: Pierre
authors: P
authors: Chue
authors: James
authors: J
authors: Chue
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D002626:Chemistry, Pharmaceutical; D002986:Clinical Trials as Topic; D006801:Humans; D007273:Injections, Intramuscular; D000077152:Olanzapine; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine