title: Lactation and neonatal nutrition: defining and refining the critical questions.
abstract: This paper resulted from a conference entitled "Lactation and Milk: Defining and refining the critical questions" held at the University of Colorado School of Medicine from January 18-20, 2012. The mission of the conference was to identify unresolved questions and set future goals for research into human milk composition, mammary development and lactation. We first outline the unanswered questions regarding the composition of human milk (Section I) and the mechanisms by which milk components affect neonatal development, growth and health and recommend models for future research. Emerging questions about how milk components affect cognitive development and behavioral phenotype of the offspring are presented in Section II. In Section III we outline the important unanswered questions about regulation of mammary gland development, the heritability of defects, the effects of maternal nutrition, disease, metabolic status, and therapeutic drugs upon the subsequent lactation. Questions surrounding breastfeeding practice are also highlighted. In Section IV we describe the specific nutritional challenges faced by three different populations, namely preterm infants, infants born to obese mothers who may or may not have gestational diabetes, and infants born to undernourished mothers. The recognition that multidisciplinary training is critical to advancing the field led us to formulate specific training recommendations in Section V. Our recommendations for research emphasis are summarized in Section VI. In sum, we present a roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond.
authors: University of Colorado School of Medicine, Aurora, CO 80045, USA. peggy.neville@ucdenver.edu
authors: Margaret C
authors: MC
authors: Neville
authors: Steven M
authors: SM
authors: Anderson
authors: James L
authors: JL
authors: McManaman
authors: Thomas M
authors: TM
authors: Badger
authors: Maya
authors: M
authors: Bunik
authors: Nikhat
authors: N
authors: Contractor
authors: Tessa
authors: T
authors: Crume
authors: Dana
authors: D
authors: Dabelea
authors: Sharon M
authors: SM
authors: Donovan
authors: Nicole
authors: N
authors: Forman
authors: Daniel N
authors: DN
authors: Frank
authors: Jacob E
authors: JE
authors: Friedman
authors: J Bruce
authors: JB
authors: German
authors: Armond
authors: A
authors: Goldman
authors: Darryl
authors: D
authors: Hadsell
authors: Michael
authors: M
authors: Hambidge
authors: Katie
authors: K
authors: Hinde
authors: Nelson D
authors: ND
authors: Horseman
authors: Russell C
authors: RC
authors: Hovey
authors: Edward
authors: E
authors: Janoff
authors: Nancy F
authors: NF
authors: Krebs
authors: Carlito B
authors: CB
authors: Lebrilla
authors: Danielle G
authors: DG
authors: Lemay
authors: Paul S
authors: PS
authors: MacLean
authors: Paula
authors: P
authors: Meier
authors: Ardythe L
authors: AL
authors: Morrow
authors: Josef
authors: J
authors: Neu
authors: Laurie A
authors: LA
authors: Nommsen-Rivers
authors: Daniel J
authors: DJ
authors: Raiten
authors: Monique
authors: M
authors: Rijnkels
authors: Victoria
authors: V
authors: Seewaldt
authors: Barry D
authors: BD
authors: Shur
authors: Joshua
authors: J
authors: VanHouten
authors: Peter
authors: P
authors: Williamson
mesh_terms: D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D035843:Biomedical Research / Q000639:trends; D001942:Breast Feeding; D002657:Child Development; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000254:growth & development / Q000382:microbiology; D007774:Lactation; D008321:Mammary Glands, Animal; D042361:Mammary Glands, Human / Q000254:growth & development* / Q000378:metabolism*; D008659:Metabolic Diseases / Q000209:etiology / Q000517:prevention & control; D008892:Milk / Q000378:metabolism; D008895:Milk, Human / Q000378:metabolism*; D009024:Morphogenesis