title: Apoptosis of peripheral blood leukocytes from rabbits infected with non-haemagglutinating strains of rabbit haemorrhagic disease virus (RHDV).
abstract: The report demonstrates that the induction of apoptosis in peripheral blood granulocytes and lymphocytes of rabbits infected with three non-haemagglutinating RHDV strains (English Rainham, German Frankfurt, and Spanish Asturias) is a crucial determinant of the pathogenesis of rabbit haemorrhagic disease. Apoptosis was measured by flow cytometric detection of caspase activity. These studies demonstrated that the investigated RHDV (rabbit haemorrhagic disease virus) viral strains affected leukocyte apoptosis to varying degrees. Enhanced leukocyte apoptosis was detected between 4 and 36 h after infection and was more pronounced in lymphocytes than in granulocytes. The data presented here thus provide a preliminary understanding of the kinetics of apoptosis in leukocytes of rabbits infected with RHDV.
authors: Department of Immunology, Faculty of Biology, University of Szczecin, Felczaka 3c St., 71-412 Szczecin, Poland. paulina.niedzwiedzka@gmail.com
authors: Paulina
authors: P
authors: Niedźwiedzka-Rystwej
authors: Wiesław
authors: W
authors: Deptuła
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D017250:Caliciviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D017929:Hemorrhagic Disease Virus, Rabbit / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D011817:Rabbits / Q000097:blood / Q000276:immunology / Q000821:virology*