title: The change in one-hour postload plasma glucose levels, and an analysis of its related factors in abdominally obese Han Chinese men with normal glucose tolerance.
abstract: OBJECTIVE
  This study was to observe the difference in one-hour postload plasma glucose levels and analyze its related factors in abdominally obese men with normal glucose tolerance (NGT).
  
  
  METHODS
  This case-control study included 36 abdominally obese men (waist circumference ≥90 cm) and 31 non-abdominally obese men (waist circumference <90 cm) aged 20-50 years with NGT. Cases and controls were matched in age. All subjects underwent oral glucose tolerance test with 75 g of oral anhydrous glucose.
  
  
  RESULTS
  0.5 and 1-h postload plasma glucose levels were higher in abdominally obese group than in non-abdominally obese group (P<.05). Fasting plasma glucose (FPG), 2 and 3-h postload plasma glucose were similar in the two groups (P>.05). 1-h postload plasma glucose was positively correlated with body mass index (r=0.454), waist circumference (WC) (r=0.519), systolic blood pressure (r=0.456), diastolic blood pressure (r=0.338), triglycerides (r=0.439), and negatively correlated with high density lipoprotein cholesterol (r=-0.391), 1/fasting insulin (r=-0.459), insulinogenic index (r=-0.357) and disposition index (r=-0.602) (P<.01). In multiple regression analysis, 1-h postload plasma glucose maintained an independent association with disposition index (β=-1.367, P=.000), WC (β=0.103, P=.000) and triglycerides (β=0.185, P=.017).
  
  
  CONCLUSIONS
  The present study demonstrated that the level of one-hour postload plasma glucose was elevated in abdominally obese men with NGT. Besides FPG and 2-h postload plasma glucose, we must also pay attention to the measurement of one-hour postload plasma glucose. Disposition index, WC and triglycerides were independently related factors for elevated one-hour postload plasma glucose.
authors: Department of Endocrinology, The First Hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, 066000, Hebei Province, China.
authors: Chun-Mei
authors: CM
authors: Qin
authors: Rui
authors: R
authors: Wang
authors: Fu-Zai
authors: FZ
authors: Yin
authors: Bo
authors: B
authors: Liu
authors: Chun-Ming
authors: CM
authors: Ma
authors: Qiang
authors: Q
authors: Lu
mesh_terms: D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D015228:Hypertriglyceridemia / Q000209:etiology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D056128:Obesity, Abdominal / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D012044:Regression Analysis; D012307:Risk Factors; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose