title: Enantioselective conjugate addition of alkylboranes catalyzed by a copper-N-heterocyclic carbene complex.
abstract: The first catalytic enantioselective conjugate addition of alkylboron compounds has been achieved. Reactions between alkylboranes and imidazol-2-yl α,β-unsaturated ketones proceeded with high enantioselectivity under the influence of a Cu(I) catalyst system, prepared in situ from CuCl, a new chiral imidazolium salt as a precursor for the N-heterocyclic carbene ligand, and PhOK. Alkylboranes are widely obtained via alkene hydroboration. A variety of functional groups are tolerated in alkylboranes and α,β-unsaturated ketones.
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Mika
authors: M
authors: Yoshida
authors: Hirohisa
authors: H
authors: Ohmiya
authors: Masaya
authors: M
authors: Sawamura