title: A common strategy for host RNA degradation by divergent viruses.
abstract: Infection with gammaherpesviruses, alphaherpesviruses, and betacoronaviruses can result in widespread mRNA degradation, in each case initiated predominantly by a single viral factor. Although not homologous, these factors exhibit significant mechanistic similarities. In cells, each targets translatable RNAs for cleavage and requires host Xrn1 to complete RNA degradation, although the mechanism of targeting and the position of the primary cleavage differ. Thus, multiple host shutoff factors have converged upon a common mRNA degradation pathway.
authors: Department of Plant and Microbial Biology, School of Public Health, University of California, Berkeley, California, USA.
authors: Marta Maria
authors: MM
authors: Gaglia
authors: Sergio
authors: S
authors: Covarrubias
authors: Wesley
authors: W
authors: Wong
authors: Britt A
authors: BA
authors: Glaunsinger
mesh_terms: D005095:Exoribonucleases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014777:Virus Diseases / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D014764:Viral Proteins; D005095:Exoribonucleases