title: Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid).
abstract: 5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope. A multi-institutional clinical trial comparing fluorescence-guided versus white light tumor resection reported significant improvement in completeness of resection and 6-month progression-free survival. The degree of 5-ALA-induced fluorescence correlates with histopathologic grade of tumor, degree of tumor cell infiltration, and proliferation indices. Quantitative methodologies for assessment of tissue fluorescence have significantly improved the ability to detect tumor tissue and intraoperative diagnostic performance. These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development.
authors: Dartmouth Medical School, Hanover, NH, USA. david.w.roberts@dartmouth.edu
authors: David W
authors: DW
authors: Roberts
authors: Pablo A
authors: PA
authors: Valdés
authors: Brent T
authors: BT
authors: Harris
authors: Alexander
authors: A
authors: Hartov
authors: Xiaoyao
authors: X
authors: Fan
authors: Songbai
authors: S
authors: Ji
authors: Frederic
authors: F
authors: Leblond
authors: Tor D
authors: TD
authors: Tosteson
authors: Brian C
authors: BC
authors: Wilson
authors: Keith D
authors: KD
authors: Paulsen
mesh_terms: D000622:Aminolevulinic Acid; D001932:Brain Neoplasms / Q000601:surgery*; D018572:Disease-Free Survival; D005456:Fluorescent Dyes; D005909:Glioblastoma / Q000601:surgery*; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D018365:Neoplasm, Residual / Q000517:prevention & control; D019635:Neurosurgical Procedures / Q000379:methods; D017319:Photosensitizing Agents; D016896:Treatment Outcome
chemical_list: D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid