title: Potential clinical utility of plasma amino acid profiling in the detection of major depressive disorder.
abstract: Plasma amino acids levels were measured in first-onset treatment-naïve depressed patients (n=26) and healthy controls (n=25) using a mass spectrometry-based method. One of the major findings was that a logistic regression model constructed from tryptophan, glutamine and cysteine discriminated depressed subjects from controls with a receiver-operating-characteristic curve integral of 0.90.
authors: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Hong-Bo
authors: HB
authors: Xu
authors: Liang
authors: L
authors: Fang
authors: Zi-Cheng
authors: ZC
authors: Hu
authors: Yi-Chen
authors: YC
authors: Chen
authors: Jian-Jun
authors: JJ
authors: Chen
authors: Fang-Fang
authors: FF
authors: Li
authors: Jia
authors: J
authors: Lu
authors: Jun
authors: J
authors: Mu
authors: Peng
authors: P
authors: Xie
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged
chemical_list: D000596:Amino Acids; D015415:Biomarkers