title: [Capacity of the oligoanuric period in the prediction of renal sequelae in patients with postdiarrheal hemolytic uremic syndrome].
abstract: BACKGROUND
  Length of the oligoanuric period is the main predictor of renal sequelae in children with postdiarrehal hemolytic uremic syndrome (D+ HUS). We aimed to determine the capacity of the oligoanuric period in the prediction of renal sequelae in children with D+ HUS.
  
  
  METHODS
  We reviewed data from all patients with D+ HUS admitted at Hospital Elizalde between 1998-2008, including only those with at least 1 year of follow-up. Renal sequelae were defined by the presence of pathologic albuminuria and/or proteinuria and/or arterial hypertension and/or chronic renal failure; 80 patients were included, belonging to one of two groups (with or without sequelae). Difference in the duration of the oligoanuric period between groups was determined, and the diagnostic capacity of the oligoanuric period to identified renal sequelae was assessed by ROC curve.
  
  
  RESULTS
  32 patients presented sequelae, representing a prevalence of 40%. Oligoanuric period was significantly longer in patients with sequelae [median 7 days (range 0-14) vs median 0 days (range 0-30); p= 0,0003]. Using ROC curve (aucROC= 0.73) we identified an oligoanuric period ≥ 4 days as the best threshold to predict renal sequelae (sensitivity 68.75%, and specificity 70.83%).
  
  
  CONCLUSIONS
  By ROC curve analysis we were unable to identify a cut-off point on the length of the oligoanuric period which predicts renal sequelae with optimum sensitivity and specificity. This observation emphasizes the need of periodic and long-term surveillance of all children who suffered from D+ HUS.
authors: Unidad de Nefrología, Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina. abalestracci@yahoo.com.ar
authors: Alejandro
authors: A
authors: Balestracci
authors: Sandra Mariel
authors: SM
authors: Martin
authors: Ismael
authors: I
authors: Toledo
authors: Silvia
authors: S
authors: Corti
authors: Raquel
authors: R
authors: Wainsztein
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D009846:Oliguria / Q000209:etiology*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors