title: Carrier-free, functionalized drug nanoparticles for targeted drug delivery.
abstract: We demonstrate a new concept of carrier-free functionalized drug nanoparticles for targeted drug delivery. It exhibits significantly enhanced drug efficacy to folate receptor-positive cells with high selectivity and a high drug loading content up to more than 78%.
authors: Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, 215123, PR China.
authors: Wei
authors: W
authors: Li
authors: Yinlong
authors: Y
authors: Yang
authors: Chao
authors: C
authors: Wang
authors: Zhuang
authors: Z
authors: Liu
authors: Xiujuan
authors: X
authors: Zhang
authors: Feifei
authors: F
authors: An
authors: Xiaojun
authors: X
authors: Diao
authors: Xiaojun
authors: X
authors: Hao
authors: Xiaohong
authors: X
authors: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism*; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008299:Maleic Anhydrides / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D058973:Folate Receptors, GPI-Anchored; D008299:Maleic Anhydrides; D011092:Polyethylene Glycols; D005492:Folic Acid; C028098:10-hydroxycamptothecin; D002166:Camptothecin