title: The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease.
abstract: Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The AIM OF THE STUDY was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development.
  
  
  METHODS
  Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn's disease) as well as 210 healthy controls.
  
  
  RESULTS
  The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn's disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively).
  
  
  CONCLUSIONS
  Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
authors: Department of Clinical Chemistry and Biochemistry, Medical University in Łódź
authors: Anna
authors: A
authors: Walczak
authors: Karolina
authors: K
authors: Przybyłowska
authors: Andrzej
authors: A
authors: Sygut
authors: Lukasz
authors: L
authors: Dziki
authors: Cezary
authors: C
authors: Chojnacki
authors: Jan
authors: J
authors: Chojnacki
authors: Adam
authors: A
authors: Dziki
authors: Ireneusz
authors: I
authors: Majsterek
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015984:Causality; D018932:Chemokine CCL2 / Q000235:genetics*; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2