title: 8-Hydroxy-2'-deoxyguanosine expression predicts hepatocellular carcinoma outcome.
abstract: Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.
authors: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
authors: Shengmian
authors: S
authors: Li
authors: Xiaoling
authors: X
authors: Wang
authors: Yijuan
authors: Y
authors: Wu
authors: Huijing
authors: H
authors: Zhang
authors: Lan
authors: L
authors: Zhang
authors: Cuiju
authors: C
authors: Wang
authors: Ruixing
authors: R
authors: Zhang
authors: Zhanjun
authors: Z
authors: Guo