title: Clinical characteristics of human immunodeficiency virus-associated Hodgkin lymphoma patients in Japan.
abstract: The incidence of Hodgkin lymphoma (HL) is paradoxically increasing in the combination anti-retroviral therapy (cART) era. However, there has been no nationwide survey of human immunodeficiency virus (HIV)-associated HL (HIV-HL) in Japan. We retrospectively examined the clinical characteristics and outcomes of 19 newly diagnosed HIV-HL patients at 11 HIV/AIDS and hematology regional hospitals in Japan between 1991 and 2010. At the time of HL diagnosis, 79 % of patients were receiving cART. All the patients, but one received HL diagnoses in the cART era. The median CD4+ cell count at HIV-HL diagnosis was 169/μl. Mixed-cellularity classical Hodgkin lymphoma was the most common subtype occurring in 68 % of the patients; 89 % of the patients were positive for Epstein-Barr virus. Of these 19 patients, 84 % were in advanced stages, with bone marrow involvement observed in 47 % of the patients; 58 % had extranodal sites. All the treated patients were given cART concurrent with HL therapy. The complete remission rate of the treated patients was 87 %. The median OS of the entire cohort was 17 months. These results suggest that the characteristics of HIV-HL in Japan are more aggressive than those of non-HIV-associated HL in Japan, but standard chemotherapy is effective and feasible.
authors: Department of Laboratory Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. mhk@tokyo-med.ac.jp
authors: Mihoko
authors: M
authors: Yotsumoto
authors: Shotaro
authors: S
authors: Hagiwara
authors: Atsushi
authors: A
authors: Ajisawa
authors: Junko
authors: J
authors: Tanuma
authors: Tomoko
authors: T
authors: Uehira
authors: Hirokazu
authors: H
authors: Nagai
authors: Yuko
authors: Y
authors: Fujikawa
authors: Shunichi
authors: S
authors: Maeda
authors: Kiyoshi
authors: K
authors: Kitano
authors: Nobuyoshi
authors: N
authors: Arima
authors: Kenji
authors: K
authors: Uno
authors: Toshiki
authors: T
authors: Iwai
authors: Igen
authors: I
authors: Hongo
authors: Yasunori
authors: Y
authors: Ota
authors: Katsuyuki
authors: K
authors: Fukutake
authors: Seiji
authors: S
authors: Okada
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016019:Survival Analysis; D016896:Treatment Outcome