title: Comparison of magnetic resonance imaging and 99mTechnetium-labelled methylene diphosphonate bone scintigraphy in the initial assessment of chronic non-bacterial osteomyelitis of childhood and adolescents.
abstract: OBJECTIVE
  To compare sensitivity of bone scintigraphy using 99mTechnetium-labelled methylene diphosphonate (Tc-99m MDP) and magnetic resonance imaging (MRI) in the detection of inflammatory bone lesions in patients with chronic non-bacterial osteomyelitis (CNO).
  
  
  METHODS
  Tc-99m MDP bone scintigraphy and MRI were performed in 32 CNO patients at the time of diagnosis and compared regarding their sensitivity in detecting inflammatory lesions in symptomatic regions of the body.
  
  
  RESULTS
  Inflammatory lesions could be detected in 40 out of the 54 (74.1%) symptomatic regions by bone scintigraphy and in 53 (98.1%) of these regions by MRI (p<0.001). Sensitivity of MRI compared to bone scintigraphy was superior in detecting lesions in the long bones of the thigh and the lower legs (100% vs. 78.4%, respectively, p<0.05).
  
  
  CONCLUSIONS
  Bone scintigraphy does not seem to display the whole extent of the inflammatory process in CNO. Therefore, depending on clinical relevance, MRI rather than planar bone scintigraphy should be considered for the detection of CNO lesions at diagnosis.
authors: Department of Paediatrics, University of Würzburg, Germany. morbach_h@klinik.uni-wuerzburg.de
authors: Henner
authors: H
authors: Morbach
authors: Peter
authors: P
authors: Schneider
authors: Tobias
authors: T
authors: Schwarz
authors: Christine
authors: C
authors: Hofmann
authors: Peter
authors: P
authors: Raab
authors: Henning
authors: H
authors: Neubauer
authors: Christian
authors: C
authors: Düren
authors: Meinrad
authors: M
authors: Beer
authors: Hermann Josef
authors: HJ
authors: Girschick
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging* / Q000473:pathology*; D011877:Radionuclide Imaging / Q000379:methods* / Q000592:standards; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate