title: Sepsis-induced cardiomyopathy.
abstract: Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both ventricles can dilate and diminish its ejection fraction, having less response to fluid resuscitation and catecholamines, but typically is assumed to be reversible within 7-10 days. In the last 30 years, It's being subject of substantial research; however no explanation of its etiopathogenesis or effective treatment have been proved yet. The aim of this manuscript is to review on the most relevant aspects of the sepsis-induced myocardial dysfunction, discuss its clinical presentation, pathophysiology, etiopathogenesis, diagnostic tools and therapeutic strategies proposed in recent years.
authors: Intensive Care Unit, Critical Care and Emergency Department, Puerto Real University Hospital, Cadiz, Spain. romerobermejo@gmail.com
authors: Francisco J
authors: FJ
authors: Romero-Bermejo
authors: Manuel
authors: M
authors: Ruiz-Bailen
authors: Julian
authors: J
authors: Gil-Cebrian
authors: Maria J
authors: MJ
authors: Huertos-Ranchal
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D017202:Myocardial Ischemia / Q000209:etiology; D009206:Myocardium / Q000378:metabolism; D009210:Myofibrils / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D018805:Sepsis / Q000150:complications* / Q000503:physiopathology; D051193:Toll-Like Receptors / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D011943:Receptors, Adrenergic, beta; D051193:Toll-Like Receptors; D002118:Calcium