title: Relationship between physical activity and brain atrophy progression.
abstract: BACKGROUND
  Brain atrophy is associated with impairment in cognitive function and learning function. The aim of this study was to determine whether daily physical activity prevents age-related brain atrophy progression.
  
  
  METHODS
  The participants were 381 men and 393 women who had participated in both the baseline and the follow-up surveys (mean duration = 8.2 yr). Magnetic resonance imaging of the frontal and temporal lobes was performed at the time of the baseline and follow-up surveys. The daily physical activities and total energy expenditures of the participants were recorded at baseline with uniaxial accelerometry sensors. Multiple logistic regression models were fit to determine the association between activity energy expenditure, number of steps, and total energy expenditure variables and frontal and temporal lobe atrophy progression while controlling for possible confounders.
  
  
  RESULTS
  In male participants, the odds ratio of frontal lobe atrophy progression for the fifth quintile compared with the first quintile in activity energy expenditure was 3.408 (95% confidence interval = 1.205-9.643) and for the number of steps was 3.651 (95% confidence interval = 1.304-10.219). Men and women with low total energy expenditure were at risk for frontal lobe atrophy progression. There were no significant differences between temporal lobe atrophy progression and physical activity or total energy expenditure.
  
  
  CONCLUSIONS
  The results indicate that physical activity and total energy expenditure are significant predictors of frontal lobe atrophy progression during an 8-yr period. Promoting participation in activities may be beneficial for attenuating age-related frontal lobe atrophy and for preventing dementia.
authors: Department for Development of Preventive Medicine, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu City, Aichi Prefecture, Japan. ats.yuki.73@gmail.com
authors: Atsumu
authors: A
authors: Yuki
authors: Sungchul
authors: S
authors: Lee
authors: Heungyoul
authors: H
authors: Kim
authors: Rumi
authors: R
authors: Kozakai
authors: Fujiko
authors: F
authors: Ando
authors: Hiroshi
authors: H
authors: Shimokata
mesh_terms: D061725:Accelerometry / Q000295:instrumentation; D000368:Aged; D001284:Atrophy / Q000473:pathology / Q000517:prevention & control; D016001:Confidence Intervals; D018450:Disease Progression; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D013702:Temporal Lobe / Q000473:pathology