title: Hyaluronidase in sub-Tenon's anesthesia for phacoemulsification, a double-blind randomized clinical trial.
abstract: OBJECTIVE
  To investigate the effect of hyaluronidase use on the quality of sub-Tenon's anaesthesia for phacoemulsification.
  
  
  METHODS
  This was a randomized, double-blind clinical trial which was conducted at Nikookari Eye Hospital for 5 months. Forty-two eyes of candidates for phacoemulsification under sub-Tenon's anaesthesia were randomly allocated to two equal groups and received either 2 mL of lidocaine 2% solution with (LH), or without (L) addition of hyaluronidase (150IU/mL). Akinesia was assessed 15 minutes after sub-Tenon's injection. Patients and surgeon's satisfaction, as well as the postoperative pain (the visual analogue scale, VAS) were investigated after operation. The contingency tables (including the Chi-square or Fisher's exact tests, when appropriate) and parametric analysis (the independent samples t test) were used for statistical analysis.
  
  
  RESULTS
  Complete akinesia (33.3% vs 4.8%, P=0.04), as well as the patients (85.7% vs 57.1%, P=0.04) and surgeon's satisfaction (87.5% vs 52.4%, P=0.02) were significantly more frequent in LH than in L group. The mean VAS was significantly lower in the same group (1.90±1.45 vs 3.00±1.55, P=0.04).
  
  
  CONCLUSIONS
  Addition of hyaluronidase to lidocaine solution for sub-Tenon's anesthesia significantly improves the ocular akinesia, enhances the intra-operative patients and surgeons' satisfaction, and attenuates the postoperative pain.
authors: Department of Ophthalmology, Tabriz University of Medical Sciences, Nikookari Eye Hospital, Tabriz, Iran.
authors: Mohammadreza
authors: M
authors: Sedghipour
authors: Ali
authors: A
authors: Mahdavifard
authors: Rohollah Fadaei
authors: RF
authors: Fouladi
authors: Davoud
authors: D
authors: Gharabaghi
authors: Mohammadbagher
authors: M
authors: Rahbani
authors: Ghasem
authors: G
authors: Amiraslanzadeh
authors: Mohammadreza
authors: M
authors: Afhami