title: Lay perspectives on hypertension and drug adherence: systematic review of qualitative research.
abstract: OBJECTIVE
  To synthesise the findings from individual qualitative studies on patients' understanding and experiences of hypertension and drug taking; to investigate whether views differ internationally by culture or ethnic group and whether the research could inform interventions to improve adherence.
  
  
  METHODS
  Systematic review and narrative synthesis of qualitative research using the 2006 UK Economic and Social Research Council research methods programme guidance.
  
  
  METHODS
  Medline, Embase, the British Nursing Index, Social Policy and Practice, and PsycInfo from inception to October 2011.
  
  
  METHODS
  Qualitative interviews or focus groups among people with uncomplicated hypertension (studies principally in people with diabetes, established cardiovascular disease, or pregnancy related hypertension were excluded).
  
  
  RESULTS
  59 papers reporting on 53 qualitative studies were included in the synthesis. These studies came from 16 countries (United States, United Kingdom, Brazil, Sweden, Canada, New Zealand, Denmark, Finland, Ghana, Iran, Israel, Netherlands, South Korea, Spain, Tanzania, and Thailand). A large proportion of participants thought hypertension was principally caused by stress and produced symptoms, particularly headache, dizziness, and sweating. Participants widely intentionally reduced or stopped treatment without consulting their doctor. Participants commonly perceived that their blood pressure improved when symptoms abated or when they were not stressed, and that treatment was not needed at these times. Participants disliked treatment and its side effects and feared addiction. These findings were consistent across countries and ethnic groups. Participants also reported various external factors that prevented adherence, including being unable to find time to take the drugs or to see the doctor; having insufficient money to pay for treatment; the cost of appointments and healthy food; a lack of health insurance; and forgetfulness.
  
  
  CONCLUSIONS
  Non-adherence to hypertension treatment often resulted from patients' understanding of the causes and effects of hypertension; particularly relying on the presence of stress or symptoms to determine if blood pressure was raised. These beliefs were remarkably similar across ethnic and geographical groups; calls for culturally specific education for individual ethnic groups may therefore not be justified. To improve adherence, clinicians and educational interventions must better understand and engage with patients' ideas about causality, experiences of symptoms, and concerns about drug side effects.
authors: King's College London, Division of Health and Social Care Research, London SE1 3QD, UK. iain.marshall@kcl.ac.uk
authors: Iain J
authors: IJ
authors: Marshall
authors: Charles D A
authors: CD
authors: Wolfe
authors: Christopher
authors: C
authors: McKevitt
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D014943:Global Health; D007722:Health Knowledge, Attitudes, Practice / Q000208:ethnology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology / Q000523:psychology; D033182:Intention; D008297:Male; D055118:Medication Adherence / Q000208:ethnology / Q000523:psychology; D036301:Qualitative Research; D013315:Stress, Psychological / Q000150:complications / Q000208:ethnology*
chemical_list: D000959:Antihypertensive Agents