title: Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A.
abstract: Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby that might contributes to tau aggregation. Thus, understanding the regulation modes of tau dephosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates and to elaborate protection strategies to cope with these lesions in AD. Among the possible and relatively specific interventions that reverse tau phosphorylation is the stimulation of certain tau phosphatases. Here, we reviewed tau protein phosphatases, their physiological roles and regulation, their involvement in tau phosphorylation and the relevance to AD. We also reviewed the most common compounds acting on each tau phosphatase including PP2A.
authors: Groupe de Neurobiologie Cellulaire, Homéostasie cellulaire et pathologies, Faculté de Médecine, Limoges, France. lmartin.phd@gmail.com
authors: Ludovic
authors: L
authors: Martin
authors: Xenia
authors: X
authors: Latypova
authors: Cornelia M
authors: CM
authors: Wilson
authors: Amandine
authors: A
authors: Magnaudeix
authors: Marie-Laure
authors: ML
authors: Perrin
authors: Faraj
authors: F
authors: Terro
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D016875:tau Proteins; D011494:Protein Kinases; D054648:Protein Phosphatase 2; D010744:Phosphoric Monoester Hydrolases