title: Phrenic nerve palsy associated with birth trauma--case reports and a literature review.
abstract: Phrenic nerve palsy is a peripheral nerve disorder caused by excessive cervical extension due to birth trauma or cardiac surgery. We describe two new patients with phrenic nerve palsy associated with birth trauma. Both patients exhibited profound dyspnea and general hypotonia immediately after birth. A chest roentgenogram and fluoroscopy revealed elevation of the diaphragm, leading to a diagnosis of phrenic nerve palsy associated with birth trauma. Since they had intermittently exhibited dyspnea and recurrent infection, we performed video-assisted thoracoscopic surgery (VATS) plication in both cases, at an early and a late stage, respectively. Both patients subsequently exhibited a dramatic improvement in dyspnea and recurrent respiratory infection. Interestingly, the late stage operated infant exhibited spontaneous recovery at 7 months with cessation of mechanical ventilation once. However, this recovery was transient and subsequently led to an increased ventilation volume demand, finally resulting in surgical treatment at 15 months. Histological examination of the diaphragm at this time showed grouped muscle atrophy caused by phrenic nerve degeneration. To our knowledge, this is the first pathologically proven report of grouped muscle atrophy of the diaphragm due to phrenic nerve degeneration, suggesting that partial impairment of phrenic nerves resulted in respiratory dysfunction with incomplete recovery. We conclude that recently developed VATS plication is a safe and effective treatment for infants with phrenic nerve palsy, and should be considered as a surgical treatment at an early period.
authors: Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Tadashi
authors: T
authors: Shiohama
authors: Katsunori
authors: K
authors: Fujii
authors: Masaharu
authors: M
authors: Hayashi
authors: Tomoro
authors: T
authors: Hishiki
authors: Maiko
authors: M
authors: Suyama
authors: Hiromi
authors: H
authors: Mizuochi
authors: Hideki
authors: H
authors: Uchikawa
authors: Shigetoshi
authors: S
authors: Yoshida
authors: Hideo
authors: H
authors: Yoshida
authors: Yoichi
authors: Y
authors: Kohno
mesh_terms: D001720:Birth Injuries / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010243:Paralysis / Q000209:etiology* / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000473:pathology; D010791:Phrenic Nerve / Q000503:physiopathology*; D012133:Respiratory Paralysis / Q000209:etiology