title: Investigation of metronidazole use during pregnancy and adverse birth outcomes.
abstract: To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital. Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated with metronidazole for clinical indications, 348 (12.3%) during the first trimester of pregnancy and 553 (19.5%) in the second or third trimester. There were 333 (11.8%) preterm births, 262 (9.3%) infants of low birth weight, and 52 infants (1.8%) with congenital anomalies. In multivariable analysis, no association was found between metronidazole treatment and preterm birth (odds ratio [OR], 1.02 [95% confidence interval [CI], 0.80 to 1.32]), low birth weight (OR, 1.05 [95% CI, 0.77 to 1.43]), or treatment in the first trimester and congenital anomalies (OR, 0.86 [0.30 to 2.45]). We found no association between metronidazole treatment during the first or later trimesters of pregnancy and preterm birth, low birth weight, or congenital anomalies.
authors: Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Catherine A
authors: CA
authors: Koss
authors: Dana C
authors: DC
authors: Baras
authors: Sandra D
authors: SD
authors: Lane
authors: Richard
authors: R
authors: Aubry
authors: Michele
authors: M
authors: Marcus
authors: Lauri E
authors: LE
authors: Markowitz
authors: Emilia H
authors: EH
authors: Koumans
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D015331:Cohort Studies; D005260:Female; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018811:Maternal Exposure; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D015999:Multivariate Analysis; D009181:Mycoses / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D009518:New York / Q000453:epidemiology; D011247:Pregnancy; D011264:Pregnancy Trimesters; D047928:Premature Birth; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D008795:Metronidazole