title: Pull and push: talin activation for integrin signaling.
abstract: The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival. The specific binding to the cytoplasmic tail of integrin's β subunit by the intracellular protein talin is the key step of inside-out signaling. A "pull-push" mechanism has been proposed to explain how the PIP2-enriched membrane disrupts the dual auto-inhibition of the N-terminal talin-FERM domain by the C-terminal talin-rod domain such that activated talin-FERM can reach the β-tail for integrin activation.
authors: College of Life Sciences, Peking University, Beijing 100871, China [2] Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. jwang@red.dfci.harvard.edu
authors: Jia-huai
authors: JH
authors: Wang
mesh_terms: D001665:Binding Sites; D002450:Cell Communication; D006801:Humans; D039641:Integrin beta Chains / Q000737:chemistry / Q000378:metabolism*; D016023:Integrins / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D055672:Static Electricity; D016608:Talin / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D039641:Integrin beta Chains; D016023:Integrins; D008024:Ligands; D019269:Phosphatidylinositol 4,5-Diphosphate; D021122:Protein Subunits; D011956:Receptors, Cell Surface; D016608:Talin; D014157:Transcription Factors