title: Reconstruction of the perineum following extralevator abdominoperineal excision for carcinoma of the lower rectum: a systematic review.
abstract: OBJECTIVE
  An improvement in oncological outcome has been reported following an extralevator approach to abdominoperineal excision (ELAPE) for low rectal carcinoma. A larger perineal defect following ELAPE and the impact of neoadjuvant radiotherapy are sources of considerable morbidity for patients. We report an evidence-based systematic review of published data on the outcome of perineal reconstruction following ELAPE for low rectal carcinoma, comparing the use of tissue flap and biological mesh techniques.
  
  
  METHODS
  A literature search was performed of electronic databases including the Medline, Embase and Scopus databases (1995-2011). Studies describing outcomes relating to the perineum following ELAPE were included for review.
  
  
  RESULTS
  Eleven small cohort studies reported the outcome relating to the perineum following ELAPE. Pooled-analysis of 255 combined patients undergoing flap repair and 85 undergoing biological mesh repair showed no significant difference in the rates of perineal wound complications or perineal hernia formation.
  
  
  CONCLUSIONS
  There is little information on the optimal technique of perineal wound closure following ELAPE. With the limited data available, there was no significant difference in complication rates between biological mesh and flap repair. There is a need for high-quality prospective trials to compare methods of reconstruction to determine the long-term results, quality of life and function.
authors: Yeovil District Hospital, Yeovil, UK.
authors: J D
authors: JD
authors: Foster
authors: S
authors: S
authors: Pathak
authors: N J
authors: NJ
authors: Smart
authors: G
authors: G
authors: Branagan
authors: R J
authors: RJ
authors: Longman
authors: M G
authors: MG
authors: Thomas
authors: N
authors: N
authors: Francis
mesh_terms: D001705:Bioprosthesis; D013505:Digestive System Surgical Procedures / Q000379:methods*; D006801:Humans; D010502:Perineum / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D012004:Rectal Neoplasms / Q000601:surgery*; D013524:Surgical Flaps; D013526:Surgical Mesh; D016896:Treatment Outcome; D014945:Wound Healing