title: Different effects of α- and γ-glycine on the aberrant activity of pyramidal neurons of hippocampal slices.
abstract: Experiments in vitro on hippocampal slices of mouse have shown that solutions prepared from polymorphic modifications α- and γ-glycine have different effect on the aberrant activity of neurons. In the presence of α-glycine the excitability of these neurons decreased more slowly, prolonging its modulating effect on NMDA type glutamate receptors. This effect agrees with higher biological activity of α-polymorphic modifications (as compared with that of the α-form) that previously observed with respect to behavior of mice from the line with genetic diathesis to catalepsy, which were used as a biological model for investigation of some pathological behavior forms.
authors: Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
authors: I A
authors: IA
authors: Malakhin
authors: A F
authors: AF
authors: Achkasov
authors: A S
authors: AS
authors: Ratushnyak
authors: T A
authors: TA
authors: Zapara
authors: A L
authors: AL
authors: Markel
authors: E V
authors: EV
authors: Boldyreva
authors: V V
authors: VV
authors: Boldyrev
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002375:Catalepsy / Q000235:genetics / Q000503:physiopathology; D005998:Glycine / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D017966:Pyramidal Cells / Q000378:metabolism* / Q000473:pathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D005998:Glycine