title: The 5-HT immunoreactive innervation of the Helix procerebrum.
abstract: In the procerebrum of terrestrial snails, 5-HT is a key modulatory substance of the generation of synchronous oscillatory activity and odor learning capability. In this study, we have analyzed the characteristics of the 5-HT-immunoreactive (5-HT-IR) innervation of the distinct anatomical regions of the procerebrum of Helix pomatia, applying correlative light- and electron microscopic immunocytochemistry. A dense network of 5-HT-IR innervation was demonstrated in the cell body layer, meanwhile a varicose fiber system of different density occurred in the different neuropil regions. At the ultrastructural level, labeled varicosities were found to contact both procerebral cell bodies, and different unlabeled axon profiles in the neuropils. The labeled structures established mostly close non-specialized membrane contacts with the postsynaptic profiles. The overall dense distribution of 5-HT-IR innervation supports a general modulatory role of 5-HT in processing different olfactory events.
authors: MTA Centre for Ecological Research, Balaton Limnological Institute, Department of Experimental Zoology, P.O. Box 35, H-8237 Tihany, Hungary.
authors: Izabella
authors: I
authors: Battonyai
authors: K
authors: K
authors: Elekes
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism / Q000648:ultrastructure*; D006372:Helix, Snails / Q000378:metabolism / Q000648:ultrastructure*; D007150:Immunohistochemistry; D012701:Serotonin / Q000378:metabolism*; D012903:Smell
chemical_list: D012701:Serotonin