title: Increased sensory feedback in Tourette syndrome.
abstract: Tourette syndrome (TS) is a neuro-psychiatric disorder being characterized by motor and phonic tics typically preceded by sensory urges. Given the latter the role of the sensory system and sensorimotor interaction in TS has recently gained increased attention. 12 TS patients and 12 matched control subjects performed two tasks, requiring simple finger movements: a Go/NoGo task and a self paced movement task. Neurophysiological data was recorded using magnetoencephalography (MEG). Event related responses around movement onset, i.e. motor field (MF) occurring directly prior to the movement and movement evoked field (MEF) immediately after movement onset were analyzed using dipole modeling. MF peak amplitudes did not differ between groups in either task. In contrast, in both tasks MEF peak amplitudes were increased in TS patients. Moreover, larger MEF amplitudes during self paced movements were inversely correlated with motor tic frequency and severity. Enlarged MEF amplitudes as a marker of early sensory feedback of one's own movements probably represent enlarged sensory input from the periphery resulting from altered subcortical gating. We conclude that TS patients exhibit altered sensory-motor processing involved in voluntary movement control, which might also be successful in tic control.
authors: Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. K.Biermann-Ruben@uni-duesseldorf.de
authors: Katja
authors: K
authors: Biermann-Ruben
authors: Anastasia
authors: A
authors: Miller
authors: Stephanie
authors: S
authors: Franzkowiak
authors: Jennifer
authors: J
authors: Finis
authors: Bettina
authors: B
authors: Pollok
authors: Claudia
authors: C
authors: Wach
authors: Martin
authors: M
authors: Südmeyer
authors: Melanie
authors: M
authors: Jonas
authors: Götz
authors: G
authors: Thomalla
authors: Kirsten
authors: K
authors: Müller-Vahl
authors: Alexander
authors: A
authors: Münchau
authors: Alfons
authors: A
authors: Schnitzler
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D019054:Evoked Potentials, Motor; D056228:Feedback, Sensory; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009068:Movement; D005879:Tourette Syndrome / Q000503:physiopathology*; D014836:Volition; D055815:Young Adult