title: Serum and urinary cytokine levels of SLE patients.
abstract: Systemic lupus erythematosus (SLE) is a chronic, relapsing, polysystemic autoimmune disease with various clinical signs. The prognosis of SLE patients is influenced by neuropsychiatric and renal involvement. Lupus nephritis (LN) is present in 40-60% of patients. Classical laboratory parameters are not sensitive and specific in prediction renal flares, over the last few years there has been a growing interest in searching novel lupus biomarkers predicting future flares. Our goal was to detect serum and urinary level of cytokines in 36 patients with lupus nephritis (34 female and 2 male, mean age: 43.36 +/- 11.53 years), 23 patients with SLE without renal involvement (19 women and 4 men, mean age: 54 +/- 8.71) (both groups followed by the 3rd Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen) and 30 healthy controls (23 female and 7 male, mean age: 45.5 +/- 12.4). Serum IL-1 (interleukin), IL-2 (both p < 0.05), IL-6, IL-13 and IFN-gamma (p < 0.001) levels were significantly higher in lupus nephritis patients, as compared to patients with SLE without renal involvement and healthy controls. Urinary level of IL-1 and TNF-alpha were significantly higher in SLE patients without renal disease (p = 0.012 and p < 0.001), while urinary IFN-gamma was significantly higher in LN patients (p = 0.002). Measurement of IL-6 level in SLE patients could help to predict future renal involvement of SLE patients.
authors: Third Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen, Hungary. brugosb@gmail.com
authors: B
authors: B
authors: Brugos
authors: Z
authors: Z
authors: Vincze
authors: S
authors: S
authors: Sipka
authors: G
authors: G
authors: Szegedi
authors: M
authors: M
authors: Zeher
mesh_terms: D000328:Adult; D015415:Biomarkers; D016207:Cytokines / Q000097:blood* / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000652:urine; D007378:Interleukins / Q000097:blood / Q000652:urine; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000652:urine*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000652:urine
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma