title: [Application of alpha-lipoic acid in clinical practice].
abstract: In the article literature data about application of alpha-lipoic acid in medical practice are summarized. The article presents characteristic of chemical structure and functional activity of alpha-lipoic acid. LA is marketed primarily as a "weight loss" and "energy" supplement and has been branded as antioxidants. Later LA has been the subject of numerous research studies and clinical trials. LA was shown to be hepatoprotective, to improve liver circulation and treat chronic liver diseases, including jaundice hepatitis, cirrhosis, and hepatic coma, to treat diabetes, and diabetic neuropathy to alter carbohydrate metabolism, atherosclerosis, coronary atherosclerosis and many others diseases. One of the most studied clinical uses of LA is the treatment of diabetes and diabetic neuropathy LA has also been used experimentally and/or clinically to prevent organ dysfunction, reduce endothelial dysfunction and improve albuminuria, treat or prevent cardiovascular disease. LA is "small" drug with very big potential.
authors: V H
authors: VH
authors: Lyzogub
authors: N V
authors: NV
authors: Altunina
authors: O M
authors: OM
authors: Bondarchuk
mesh_terms: D000419:Albuminuria / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D050260:Carbohydrate Metabolism / Q000187:drug effects; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000378:metabolism; D019610:Cytoprotection; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D008063:Thioctic Acid / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid