title: ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.
abstract: Integrin-linked kinase (ILK) is a widely expressed and evolutionally conserved component of cell-extracellular matrix (ECM) adhesions. Although initially named as a kinase, ILK contains an unusual pseudoactive site that is incapable of catalyzing phosphorylation. Instead, ILK acts as a central component of a heterotrimer (the PINCH-ILK-parvin complex) at ECM adhesions mediating interactions with a large number of proteins via multiple sites including its pseudoactive site. Through higher level protein-protein interactions, this scaffold links integrins to the actin cytoskeleton and catalytic proteins and thereby regulates focal adhesion assembly, cytoskeleton organization and signaling. This review summarizes recent advances in our understanding of the structure and functions of the PINCH-ILK-parvin complex, and discusses emerging new features of the molecular mechanisms by which it regulates diverse cellular, physiological and pathological processes.
authors: Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. qinj@ccf.org
authors: Jun
authors: J
authors: Qin
authors: Chuanyue
authors: C
authors: Wu
mesh_terms: D000818:Animals; D021982:Cell-Matrix Junctions / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004194:Disease; D047108:Embryonic Development; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D010766:Phosphorylation; D055503:Protein Multimerization; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D000099200:Scaffold Protein ILK
chemical_list: D004268:DNA-Binding Proteins; D016023:Integrins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK