title: General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.
abstract: An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.
authors: College of Pharmacy, The University of Arizona, Oro Valley, 85737, United States.
authors: Zhigang
authors: Z
authors: Xu
authors: Muhammad
authors: M
authors: Ayaz
authors: Alexandra A
authors: AA
authors: Cappelli
authors: Christopher
authors: C
authors: Hulme
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D007769:Lactams; D011108:Polymers; C031000:benzimidazole