title: A case of BK virus nephropathy and cytomegalovirus infection concurrent with plasma cell-rich acute rejection.
abstract: The BK virus is a double-stranded DNA virus to which 90% of adults have been exposed. BK virus infections typically result in an oral or respiratory infection; however, BK virus reactivation is an infectious disease of concern in kidney transplant recipients. The prevalence of BK virus nephropathy (BKN) in kidney transplant recipients is approximately 5%, and most cases occur within one yr after kidney transplantation. Graft survival of BKN is reported to be 30-60%, and the standard treatment strategy for BKN is reducing immunosuppressive therapy and close monitoring for rejection. Viral infection is most common in the early post-transplantation phase, and BKN or acute rejection is one of the major factors involved in graft loss. However, in this report, we describe the successful management of BKN and cytomegalovirus infection concurrent with plasma cell-rich acute rejection.
authors: Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. mafuaki@gmail.com
authors: Aki
authors: A
authors: Mafune
authors: Yudo
authors: Y
authors: Tanno
authors: Hiroyasu
authors: H
authors: Yamamoto
authors: Akimitsu
authors: A
authors: Kobayashi
authors: Hajime
authors: H
authors: Saigawa
authors: Takashi
authors: T
authors: Yokoo
authors: Hiroshi
authors: H
authors: Hayakawa
authors: Youichi
authors: Y
authors: Miyazaki
authors: Keitaro
authors: K
authors: Yokoyama
authors: Yutaka
authors: Y
authors: Yamaguchi
authors: Tatsuo
authors: T
authors: Hosoya
mesh_terms: D000328:Adult; D001739:BK Virus / Q000472:pathogenicity; D003587:Cytomegalovirus / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D006084:Graft Rejection / Q000209:etiology*; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D010950:Plasma Cells / Q000473:pathology*; D027601:Polyomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D011183:Postoperative Complications; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*
chemical_list: D004279:DNA, Viral; D007166:Immunosuppressive Agents