title: Bimetallic complexes constructed from asymmetrical N,N'-bis(substituted)-oxamide: cytotoxicities, and reactivities towards DNA and protein.
abstract: A new asymmetrical N,N'-bis(substituted)oxamide ligand, N-(5-chloro-2-hydroxyphenyl)-N'-[3-(dimethylamino)propyl]oxamide (C(13)H(18)N(3)O(3)Cl·H(2)O, H(3)L) and its two binuclear complexes [Cu(2)L(H(2)O)(bpy)](ClO(4))·CH(3)OH (1) and [Ni(2)L(bpy)(2)](ClO(4)) (2) [bpy = 2,2'-bipyridine] have been synthesized and characterized by X-ray single-crystal diffraction. In the crystal structure, H(3)L adopting a transoid conformation occurs as a neutral molecule linked with a water molecule by an intermolecular hydrogen bond. In the two complexes, the cis-L(3-) ligand bridges two metal ions with the corresponding separations of 5.2032(15) Å (1) and 5.2466(7) Å (2), respectively. In vitro cytotoxic activities, and the reactivities of the three compounds towards DNA and protein are investigated.
authors: Marine Drug & Food Institute, Ocean University of China, 5 Yu shan Road, Qingdao 266003, PR China.
authors: Xiao-Wen
authors: XW
authors: Li
authors: Lin
authors: L
authors: Tao
authors: Yan-Tuan
authors: YT
authors: Li
authors: Zhi-Yong
authors: ZY
authors: Wu
authors: Cui-Wei
authors: CW
authors: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002417:Cattle; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D012710:Serum Albumin, Bovine; D004247:DNA; D010072:Oxamic Acid; C008728:oxamide