title: The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO): moving from baseline characteristics to research perspectives.
abstract: The objective of this study is to construct an International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO). The main goal of this database is to determine outcome-based diagnostic thresholds for the self-measured home blood pressure (BP). Secondary objectives include investigating the predictive value of white-coat and masked hypertension, morning and evening BP, BP and heart rate variability, and the home arterial stiffness index. We also aim to determine an optimal schedule for home BP measurements that provides the most accurate risk stratification. Eligible studies are population-based, have fatal as well as nonfatal outcomes available for analysis, comply with ethical standards, and have been previously published in peer-reviewed journals. In a meta-analysis based on individual subject data, composite and cause-specific cardiovascular events will be related to various indexes derived by home BP measurement. The analyses will be stratified by a cohort and adjusted for the clinic BP and established cardiovascular risk factors. The database includes 6753 subjects from five cohorts recruited in Ohasama, Japan (n=2777); Finland (n=2075); Tsurugaya, Japan (n=836); Didima, Greece (n=665); and Montevideo, Uruguay (n=400). In these five cohorts, during a total of 62 106 person-years of follow-up (mean 9.2 years), 852 subjects died and 740 participants experienced a fatal or nonfatal cardiovascular event. IDHOCO provides a unique opportunity to investigate several hypotheses that could not reliably be studied in individual studies. The results of these analyses should be of help to clinicians involved in the management of patients with suspected or established hypertension.
authors: Department of Chronic Disease Prevention, Population Studies Unit, National Institute for Health and Welfare, Turku, Finland.
authors: Teemu J
authors: TJ
authors: Niiranen
authors: Lutgarde
authors: L
authors: Thijs
authors: Kei
authors: K
authors: Asayama
authors: Jouni K
authors: JK
authors: Johansson
authors: Takayoshi
authors: T
authors: Ohkubo
authors: Masahiro
authors: M
authors: Kikuya
authors: José
authors: J
authors: Boggia
authors: Atsushi
authors: A
authors: Hozawa
authors: Edgardo
authors: E
authors: Sandoya
authors: George S
authors: GS
authors: Stergiou
authors: Ichiro
authors: I
authors: Tsuji
authors: Antti M
authors: AM
authors: Jula
authors: Yutaka
authors: Y
authors: Imai
authors: Jan A
authors: JA
authors: Staessen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000639:trends*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D015331:Cohort Studies; D016208:Databases, Factual / Q000639:trends*; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006115:Greece; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D014583:Uruguay; D059466:White Coat Hypertension / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology