title: Prevalence of cerebral aneurysm in patients with acromegaly.
abstract: The prevalence of cerebral aneurysm was retrospectively investigated in 208 patients with acromegaly relative to the rate of cerebral aneurysm in a group of control subjects. Neuroradiological examinations of the cerebral vascular system were conducted in 208 acromegaly patients (101 men; mean age, 48.8 years). The prevalence of cerebral aneurysm in the acromegaly patients was compared to that in a control group consisting of 7,390 subjects who underwent "brain checkup" between 2006 and 2008 (mean age, 51.6 years). In the acromegaly group, cerebral aneurysm was detected in 4.3 % of patients. By sex, the prevalence was 6.9 % in males, a significantly proportion than that in the control group with an odds ratio of 4.40. The prevalence in females did not differ between the two groups. In the acromegaly group, the rate of hypertension was significantly higher in the patients with aneurysm compared to those without aneurysm. Multiple logistic regression identified acromegaly as a significant factor related to the prevalence of cerebral aneurysm in all male subjects; other factors, such as age, hypertension and smoking, were not found to be significant. A significantly higher prevalence of cerebral aneurysm was detected in male patients with acromegaly. This finding indicates that excess growth hormone or insulin-like growth factor 1 affects the cerebral vascular wall, resulting in aneurysm formation. In addition to known systematic complications in the cardiovascular, respiratory, metabolic, and other systems, the risk of cerebral aneurysm should be considered in the management of acromegaly.
authors: Department of Neurosurgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: Satoru
authors: S
authors: Oshino
authors: Akio
authors: A
authors: Nishino
authors: Tsuyoshi
authors: T
authors: Suzuki
authors: Hideyuki
authors: H
authors: Arita
authors: Akihiro
authors: A
authors: Tateishi
authors: Katsumi
authors: K
authors: Matsumoto
authors: Toshio
authors: T
authors: Shimokawa
authors: Manabu
authors: M
authors: Kinoshita
authors: Toshiki
authors: T
authors: Yoshimine
authors: Youichi
authors: Y
authors: Saitoh
mesh_terms: D000172:Acromegaly / Q000453:epidemiology* / Q000378:metabolism; D000328:Adult; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D002532:Intracranial Aneurysm / Q000453:epidemiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I