title: Characteristics and antioxidant activities of silymarin nanoparticles.
abstract: Silymarin, a well known hepatoprotective drug, has been routinely used in treating liver disorders. However, its bioavailability and therapeutic efficiency are limited by the poor aqueous solubility. In this study, we used the nanoprecipitation technique to develop a nanoparticles system to improve the solubility of silymarin. The newly developed silymarin nanoparticles were characterized for mean particle size, morphology, intermolecular interaction, crystalline features and dissolution property, as well as assessing for antioxidant activities. Results indicated that a drastic change in the physiochemical properties of silymarin was noted in the form of nanoparticles, as displayed by the extremely small particle size (46.1 +/- 1.73 nm), the formation of intermolecular hydrogen bonding between silymarin and matrix of nanoparticles, and the rendering of amorphous state. These phenomena have contributed to the enhanced dissolution property of silymarin nanoparticles, as well as a greater potency in DPPH radical scavenging, anti-superoxide anion formation, and superoxide anion scavenging activities than the crude silymarin. The present study concludes that silymarin nanoparticles have an improved physicochemical property as demonstrated by an increased solubility and enhanced antioxidant activities.
authors: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Wen-Chan
authors: WC
authors: Hsu
authors: Lean-Teik
authors: LT
authors: Ng
authors: Tzu-Hui
authors: TH
authors: Wu
authors: Liang-Tzung
authors: LT
authors: Lin
authors: Feng-Lin
authors: FL
authors: Yen
authors: Chun-Ching
authors: CC
authors: Lin
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D012838:Silymarin / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D012838:Silymarin