title: Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.
abstract: A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.
authors: Istituto Pasteur Cenci Bolognetti - Dip. Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
authors: Rossella
authors: R
authors: Fioravanti
authors: Ignacio
authors: I
authors: Celestino
authors: Roberta
authors: R
authors: Costi
authors: Giuliana
authors: G
authors: Cuzzucoli Crucitti
authors: Luca
authors: L
authors: Pescatori
authors: Leonardo
authors: L
authors: Mattiello
authors: Ettore
authors: E
authors: Novellino
authors: Paola
authors: P
authors: Checconi
authors: Anna Teresa
authors: AT
authors: Palamara
authors: Lucia
authors: L
authors: Nencioni
authors: Roberto
authors: R
authors: Di Santo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009980:Influenza A virus / Q000187:drug effects* / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010084:Oxidation-Reduction; D059808:Polyphenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D059808:Polyphenols