title: Conditioning with α-emitter based radioimmunotherapy in canine allogeneic hematopoietic cell transplantation.
abstract: With the introduction of nonmyeloablative conditioning, hematopoietic cell transplantation (HCT) has become a viable treatment option for patients who due to age or comorbidities are ineligible for high dose conditioning. However, relapse and toxicities are still major problems in HCT. Radioimmunotherapy (RIT)-based conditioning is a promising approach that has the ability to specifically target radiation to hematopoietic cells. The most widely investigated isotopes are the β-emitters, but because of long path lengths and low linear energy transfer, α-emitters which have more favorable physical characteristics, might prove to be a better alternative. In the current study we have investigated the efficacy and safety of α-emitter based RIT as the only form of conditioning in a preclinical model of canine allogeneic HCT.
authors: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors: Brian
authors: B
authors: Kornblit
authors: Yun
authors: Y
authors: Chen
authors: Brenda M
authors: BM
authors: Sandmaier
mesh_terms: D000512:Alpha Particles; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D001729:Bismuth / Q000737:chemistry; D004285:Dogs; D006084:Graft Rejection / Q000276:immunology; D019337:Hematologic Neoplasms / Q000532:radiotherapy; D018380:Hematopoietic Stem Cell Transplantation; D007694:Killer Cells, Natural / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000276:immunology; D016499:Radioimmunotherapy; D011868:Radioisotopes / Q000737:chemistry; D014184:Transplantation, Homologous
chemical_list: D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D017493:Leukocyte Common Antigens; D001729:Bismuth