title: Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression.
abstract: BACKGROUND
  Onset of puberty is dependent on pulsatile secretion of gonadotropin releasing hormone (GnRH). The kisspeptin-GPR54 signaling system has a considerable role in GnRH physiology and induction of puberty.
  
  
  OBJECTIVE
  To evaluate kisspeptin levels in girls with central precocious puberty (CPP) at the time of the diagnosis and during follow-up, to determine whether or not kisspeptin may serve as a marker for diagnosis and follow-up of CPP.
  
  
  METHODS
  Kisspeptin levels of 28 girls with CPP were measured at the time of diagnosis and repeated at the 6th month of therapy after complete pubertal suppression and compared to kisspeptin levels of 13 age-matched prepubertal controls.
  
  
  RESULTS
  Kisspeptin levels of girls with CPP (10.2 +/- 2.6 pg/mL) were higher than those in controls (8.6 +/- 1.5 pg/mL (p = 0.019). There was a significant decline in the kisspeptin levels (7.3 +/- 1.3 pg/mL) of girls with CPP after pubertal suppression (p < 0.0001).
  
  
  CONCLUSIONS
  These findings suggest that kisspeptin levels can be used as corroborative evidence for diagnosis of CPP and a valuable parameter for monitoring treatment efficacy.
authors: Division of Pediatric Endocrinology, Hacettepe University Medical School, Sihhiye, Ankara, Turkey. dr_huseyin@hotmail.com
authors: Huseyin
authors: H
authors: Demirbilek
authors: Elmas Nazli
authors: EN
authors: Gonc
authors: Alev
authors: A
authors: Ozon
authors: Ayfer
authors: A
authors: Alikasifoglu
authors: Nurgun
authors: N
authors: Kandemir
mesh_terms: D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D059648:Kisspeptins / Q000097:blood*; D007986:Luteinizing Hormone / Q000378:metabolism*; D011379:Prognosis; D011627:Puberty / Q000378:metabolism*; D011629:Puberty, Precocious / Q000097:blood* / Q000175:diagnosis*
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone