title: The Relation of Urinary 8-OHdG, A Marker of Oxidative Stress to DNA, and Clinical Outcomes for Ischemic Stroke.
abstract: BACKGROUND
  Oxidative stress/free radical generation after ischemic stroke contributes to neuronal cell injury. We evaluated the utility of an oxidative stress marker, urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), to demonstrate an association between the changes of 8-OHdG and outcomes after acute ischemic stroke.
  
  
  METHODS
  We enrolled 44 patients (26 males and 18 females) who visited our hospital due to acute ischemic stroke. Urine was collected on admission and on Days 7, and 8-OHdG was measured by ELISA. The relationships between 8-OHdG levels, stroke subtypes, and clinical outcomes based on the NIHSS and modified Rankin Scale (mRS) upon discharge was evaluated.
  
  
  RESULTS
  In the overall cohort, the mean urinary level of 8-OHdG on Day 7 was increased than that on Day 0. The 8-OHdG levels on Day 0 were not different between patients with poor and good outcomes. However, an increasing rate from Day 0 to 7 (Δ 8-OHdG) in stroke patients with a poor outcome(mRS ≥3) was significantly higher than those with a good outcome (mRS ≤2) (2.54 vs 39.44, p = 0.004).
  
  
  CONCLUSIONS
  The biochemical changes related to 8-OHdG and oxidative stress may be considered a marker of ischemic brain injury and clinical outcome of ischemic stroke.
authors: Department of Internal Medicine, Seikeikai Hospital, Sakai 590-0024, Japan.
authors: Hideto
authors: H
authors: Nakajima
authors: Ki-Ichi
authors: K
authors: Unoda
authors: Takumi
authors: T
authors: Ito
authors: Haruko
authors: H
authors: Kitaoka
authors: Fumiharu
authors: F
authors: Kimura
authors: Toshiaki
authors: T
authors: Hanafusa