title: Posttranslational modifications in connexins and pannexins.
abstract: Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function. In this review, we assess the evidence for ubiquitination, glycosylation, phosphorylation, S-nitrosylation as well as other modifications in connexins and pannexin proteins. Based on the literature, we find that posttranslational modifications are an important component of connexin and pannexin regulation.
authors: Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
authors: Scott R
authors: SR
authors: Johnstone
authors: Marie
authors: M
authors: Billaud
authors: Alexander W
authors: AW
authors: Lohman
authors: Evan P
authors: EP
authors: Taddeo
authors: Brant E
authors: BE
authors: Isakson
mesh_terms: D000818:Animals; D017630:Connexins / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination
chemical_list: D017630:Connexins