title: Using a 2D multibreath-hold susceptibility-weighted imaging to visualize intratumoral hemorrhage of hepatocellular carcinoma at 3T MRI: correlation with pathology.
abstract: OBJECTIVE
  To assess the value of 2D multibreath-hold susceptibility-weighted imaging (SWI) for visualizing intratumoral hemorrhage of hepatocellular carcinoma (HCC) and correlate with pathological results.
  
  
  METHODS
  Fifty-eight patients with 65 HCCs underwent T1-, T2-, T2-weighted imaging and SWI. The ability to detect intratumoral hemorrhage for each imaging technique was evaluated. A radiologic-pathological correlation was performed.
  
  
  RESULTS
  The area under the receiver operator characteristic (ROC) curve (Az value) for SWI (Az = 0.941) was significantly greater than that for T1WI (Az = 0.748) and T2WI (Az = 0.700) (P = 0.000). When compared with T2, SWI had slightly higher sensitivity and equal specificity, but the Az value was not significantly different (P = 0.768). The total number of hemorrhages detected by SWI was greatest by factors of 13.3, 6.7, and 2.2 compared to T1WI, T2WI, and T2, respectively. SWI detected more microbleeds (585 in 25 HCCs) than T1WI (13 in 5 HCCs), T2WI (66 in 11 HCCs), and T2 (238 in 21 HCCs).
  
  
  CONCLUSIONS
  SWI can accurately visualize internal hemorrhages and provide valuable information regarding the internal architecture of HCC.
authors: Department of Diagnostic Radiology, Zhongshan Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
authors: Ruo-Kun
authors: RK
authors: Li
authors: Meng-Su
authors: MS
authors: Zeng
authors: Sheng-Xiang
authors: SX
authors: Rao
authors: Jin-Wei
authors: JW
authors: Qiang
authors: Yong-Ming
authors: YM
authors: Dai
authors: Yuan
authors: Y
authors: Ji
authors: Cai-Zhong
authors: CZ
authors: Chen
authors: Jerecic
authors: J
authors: Renate
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D062485:Breath Holding; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic