title: Case of interstitial lung disease with anti-EJ and anti-CCP antibodies preceding rheumatoid arthritis.
abstract: Autoantibodies against aminoacyl-tRNA synthetases (ARSs) are highly specific for myositis and/or interstitial lung disease. We report a rare case of double positive antibodies (anti-EJ antibody, the least common among anti-aminoacyl-tRNA synthetase antibodies, and anti-cyclic citrullinated peptide antibody, reported to be specific for rheumatoid arthritis) in a patient who presented with interstitial lung disease and later developed rheumatoid arthritis. The patient did not have clinically apparent myositis over a period of careful follow-up of several years. The initial pulmonary pathologic findings showed a nonspecific interstitial pneumonia pattern, with the formation of lymphoid follicles, which should be recognized as the first manifestation of rheumatoid arthritis.
authors: Department of Respiratory Medicine, Kobe City Medical Center West Hospital, 4, 2-chome, Ichibancho, Nagata-ku, Kobe 653-0013, Japan. htomy@kobe-nishishimin-hospi.jp
authors: Hiromi
authors: H
authors: Tomioka
authors: Masahiro
authors: M
authors: Kaneko
authors: Yoshinori
authors: Y
authors: Kogata
authors: Eiji
authors: E
authors: Katsuyama
authors: Seiko
authors: S
authors: Ishikawa
authors: Takao
authors: T
authors: Fujii
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009220:Myositis; D010456:Peptides, Cyclic / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D000604:Amino Acyl-tRNA Synthetases