title: Extraperitoneal response to intraperitoneal immunotherapy with catumaxomab in a patient with cutaneous lymphangiosis carcinomatosa from ovarian cancer: a case report and review of the literature.
abstract: Cutaneous metastasation is a very rare manifestation of ovarian cancer. We present the case of a 64-year-old woman with recurrent platinum-refractory ovarian cancer and skin metastasis. The patient was treated with intraperitoneal catumaxomab due to massive refractory malignant ascites. Clinical response of the skin metastasis was observed during the intraperitoneal treatment with catumaxomab. Even though response of extraperitoneal tumor sites can be explained with intravascular uptake and a possible vaccination effect, this phenomenon has not been reported up to this point to the best of our knowledge.
authors: Department of Gynecology, European Competence Center for Ovarian Cancer, Charité-Campus Virchow Klinikum, Medical University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
authors: H
authors: H
authors: Woopen
authors: K
authors: K
authors: Pietzner
authors: S
authors: S
authors: Darb-Esfahani
authors: G
authors: G
authors: Oskay-Oezcelik
authors: J
authors: J
authors: Sehouli
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000188:drug therapy* / Q000556:secondary*; D018033:Antibodies, Bispecific / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001201:Ascites / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007263:Infusions, Parenteral; D008875:Middle Aged; D009366:Neoplasm Seeding; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000556:secondary; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary*
chemical_list: D018033:Antibodies, Bispecific; D000970:Antineoplastic Agents; C522419:catumaxomab