title: Preoperative clinical factors for diagnosis of incidental prostate cancer in the era of tissue-ablative surgery for benign prostatic hyperplasia: a korean multi-center review.
abstract: OBJECTIVE
  To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH).
  
  
  METHODS
  From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated.
  
  
  RESULTS
  IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685).
  
  
  CONCLUSIONS
  IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.
authors: Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
authors: Changhee
authors: C
authors: Yoo
authors: Cheol Young
authors: CY
authors: Oh
authors: Se Joong
authors: SJ
authors: Kim
authors: Sun Il
authors: SI
authors: Kim
authors: Young Sig
authors: YS
authors: Kim
authors: Jong Yeon
authors: JY
authors: Park
authors: Do Hwan
authors: do H
authors: Seong
authors: Yun Seob
authors: YS
authors: Song
authors: Won Jae
authors: WJ
authors: Yang
authors: Hyun Chul
authors: HC
authors: Chung
authors: In Rae
authors: IR
authors: Cho
authors: Sung Yong
authors: SY
authors: Cho
authors: Sang Hyeon
authors: SH
authors: Cheon
authors: Sungjoon
authors: S
authors: Hong
authors: Jin Seon
authors: JS
authors: Cho