title: [Fulminant hepatic failure due to tuberculostatic drugs: case report].
abstract: Hepatoxicity of isoniazid, mainly in association with rifampin, is a rare secondary effect of tuberculostatic treatment. In the United States, it accounts for 0.2% of all pediatric orthotropic liver transplant, and 14% of transplants for drug hepatotoxicity. We report the case of a 10 year-old patient who presented with acute liver failure requiring orthotropic liver transplant after forty days of tuberculostatic treatment with isoniazid, rifampin and pyrazinamide.
authors: Hepatología y trasplante hepático pediátrico, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina. imalla@cas.austral.edu.ar
authors: Ivone
authors: I
authors: Malla
authors: Martín
authors: M
authors: Fauda
authors: Enrique
authors: E
authors: Casanueva
authors: María Isabel
authors: MI
authors: Fernández
authors: Marcelo
authors: M
authors: Amante
authors: Yu
authors: Y
authors: Cheang
authors: Gisela
authors: G
authors: Giacove
authors: Alejandra
authors: A
authors: Pedreira
authors: Pablo
authors: P
authors: Petracca
authors: Ariel
authors: A
authors: González Campaña
authors: Marcelo
authors: M
authors: Silva
authors: Gustavo
authors: G
authors: Podestá
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D017114:Liver Failure, Acute / Q000139:chemically induced*; D011718:Pyrazinamide / Q000009:adverse effects*; D012293:Rifampin / Q000009:adverse effects*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin