title: [Experimental study of influence of different damaging factors on lens. Report 2. Features of microscopic lens changes].
abstract: Microscopic lens changes are studied in mice (F1C57B1XCBA) depending on age and after ultraviolet (UV), gamma-irradiation and their combination. In all animals compared to young 3-months animals nonspecific changes due to aging were revealed: microvacuoles in cytoplasm of fiber cells, flattening of epithelial cells and nuclei fragmentation, swelling and confluence of cortical layer cells in anterior and posterior subcapsular zones. In epithelial cells the following changes were noted: nuclei polymorphism, cavities in a cell layer formation of multilayered structures of fibroblast-like cells and cell desquamation. Degree of nuclei vacuolization was significantly lower in groups with gamma- and gamma+UV-irradiation but higher in a group of UV exposure. The number of cells per unit area was significantly decreased in a group of gamma-irradiation after 7 and 10 months of exposure. Aging and UV exposure caused decrease of nuclei area, whereas affect of gamma-irradiation depended on proliferative capacity of cells: size of central cells increased and of peripheral cells reduced. Specific changes were not revealed for any of the factors.
authors: K O
authors: KO
authors: Muranov
authors: N B
authors: NB
authors: Polianskiĭ
authors: K I
authors: KI
authors: Bannik
authors: N L
authors: NL
authors: Sheremet
authors: A A
authors: AA
authors: Fedorov
authors: V S
authors: VS
authors: Kurova
authors: G S
authors: GS
authors: Polunin
authors: M A
authors: MA
authors: Ostrovskiĭ
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008853:Microscopy / Q000379:methods; D012720:Severity of Illness Index; D014466:Ultraviolet Rays / Q000009:adverse effects*