title: Standardised mortality is increased three-fold in a population-based sample of children and adolescents with type 1 diabetes.
abstract: There are no type 1 diabetes (T1DM) mortality data on Australian children and limited contemporary data on their international counterparts. Fatalities in children and adolescents (1-17 yr) with T1DM were identified from the Western Australia Children's Diabetes Database between 1987-2011. Seventeen thousand four hundred and fifty-three patient-years of diabetes data were analysed and 13 deaths were confirmed (six male). The overall standardised mortality ratio was 3.1 [95% confidence interval (CI), 1.7-5.3] and was highest in the 10-14 yr age group, at 4.6 (95% CI, 1.5-10.8). Median age at death was 16.4 yr (range 5 to 17.8 yr), and median haemoglobin A1c at death was 10.5% (range 6.7 to >14). Cause of death was attributed to diabetes in 10 (77%) cases. Two patients were found 'dead-in-bed'. All diabetes-related deaths in subjects with known T1DM occurred outside the hospital setting.
authors: Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, 6008, Australia.
authors: Michael Joseph
authors: MJ
authors: O'Grady
authors: Joanna
authors: J
authors: Delaney
authors: Timothy William
authors: TW
authors: Jones
authors: Elizabeth Ann
authors: EA
authors: Davis
mesh_terms: D000293:Adolescent; D002423:Cause of Death; D002648:Child; D046688:Child Mortality / Q000639:trends*; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000401:mortality*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011153:Population; D012015:Reference Standards; D015854:Up-Regulation; D014904:Western Australia / Q000453:epidemiology