title: Guidance of stem cell fate on 2D patterned surfaces.
abstract: Stem cells possess unique abilities as they can renew themselves for extended periods of time and have the capacity to differentiate into a variety of lineages. They hold promise for treating a plethora of diseases ranging from musculoskeletal defects to myocardial infarction and to neural disorders. Understanding how to control the fate decision of these cells to self-renew or differentiate is paramount in stem cell tissue engineering. Recently, significant progress has been made in guiding stem cell differentiation in vitro, and we are beginning to understand the complex interplay of factors that control their fate. Here, we highlight the recent approaches for guidance of stem cells through patterning of surfaces at the micro- and nanoscale. Particular attention is given to chemical patterning of substrates with adhesion ligands and physical patterning with a variety of topographical features. These surface-mediated biochemical and mechanical cues have proven influential in altering a wide range of stem cell phenotypes. This approach to guide or ultimately control stem cells by surface patterning has enormous potential implications in cell therapies and regenerative medicine.
authors: Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark.
authors: Kristian
authors: K
authors: Kolind
authors: Kam W
authors: KW
authors: Leong
authors: Flemming
authors: F
authors: Besenbacher
authors: Morten
authors: M
authors: Foss
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D049109:Cell Proliferation; D060833:Cellular Microenvironment / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D048091:Guided Tissue Regeneration; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology; D044968:Regenerative Medicine / Q000639:trends; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D013499:Surface Properties; D023822:Tissue Engineering / Q000639:trends*