title: Association of KIR genotype with susceptibility to HLA-B27-positive ankylosing spondylitis.
abstract: OBJECTIVE
  Recent studies have explored the role of killer cell immunoglobulin-like receptors (KIRs) in chronic autoimmune diseases. The purpose of this study was to demonstrate whether KIR genes contribute to the pathogenesis of ankylosing spondylitis (AS) in Chinese populations.
  
  
  METHODS
  Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP. The frequencies of the KIR alleles and genotypes in the AS and control groups were assessed by the χ(2) test.
  
  
  RESULTS
  Our results showed that the frequency of the activator receptor KIR3DS1 gene in the AS group was significantly increased compared to the controls (χ(2) = 5.263, P = 0.006, OR = 3.059, 95 % CI = 1.357-6.896). Moreover, the frequency of the KIR3DL1/3DS1 genotype was greater in the AS group than in the control group (P = 0.039, OR = 3.059, 95 % CI = 1.357-6.896). In contrast, the frequency of the no KIR3DL1/no 3DS1 genotype was lower in patients with AS compared with the controls (P = 0.032, OR = 0.110, 95 % CI = 0.013-0.911).
  
  
  CONCLUSIONS
  KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of AS in the Chinese population.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors: Sheng
authors: S
authors: Wang
authors: Guixing
authors: G
authors: Li
authors: Rui
authors: R
authors: Ge
authors: Zhenhua
authors: Z
authors: Duan
authors: Zhen
authors: Z
authors: Zeng
authors: Tianchen
authors: T
authors: Zhang
authors: Jing
authors: J
authors: Gao
authors: Ting
authors: T
authors: Yang
authors: Si
authors: S
authors: Liu
authors: Shanshan
authors: S
authors: Wu
authors: Dazhi
authors: D
authors: Fan
authors: Shengqian
authors: S
authors: Xu
authors: Jianhua
authors: J
authors: Xu
authors: Li
authors: L
authors: Zhang
authors: Zongwen
authors: Z
authors: Shuai
authors: Dongqing
authors: D
authors: Ye
authors: Yanfeng
authors: Y
authors: Zou
authors: Faming
authors: F
authors: Pan
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D054349:Receptors, KIR3DS1 / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen; D054349:Receptors, KIR3DS1