title: Reduced silicone oil adherence to silicone intraocular lens by surface modification with 2-methacryloyloxyethyl phosphoryl-choline.
abstract: OBJECTIVE
  to evaluate and compare the interaction of silicone oil-intraocular lens (IOLs) biomaterial in 2-methacryloyloxyethyl phosphoryl-choline (MPC) -modified IOLs and various widely used IOLs in vitro.
  
  
  METHODS
  Five groups of foldable IOLs, including 3-piece hydrophobic silicone IOLs, MPC-modified silicone IOLs, 3-piece hydrophilic hydrogel IOLs, one-piece hydrophilic acrylic IOLs and one-piece hydrophobic acrylic IOLs were photographed after immersion in silicone oil. The silicone oil coverage of the anterior and posterior surfaces of each IOL was measured using EPCO Image-analysis software. The hydrophilicity of the IOL surface was characterized by the water contact angle.
  
  
  RESULTS
  hydrophilic IOLs, such as MPC-modified silicone IOLs, hydrophilic acrylic IOLs and hydrogel IOLs having a lower contact angle exhibited less silicone oil adherence than hydrophobic IOLs, including both silicone IOLs and hydrophobic acrylic IOLs (p = 0.000, p < 0.05).
  
  
  CONCLUSIONS
  MPC-modified hydrophilic silicone IOLs reduce silicone oil adherence, and thus may meet the need of a foldable IOL suitable for vitreoretinal patients.
authors: Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China.
authors: Xiao-Dan
authors: XD
authors: Huang
authors: He-Yi
authors: HY
authors: Li
authors: Lin
authors: L
authors: Lin
authors: Ke
authors: K
authors: Yao
mesh_terms: D001672:Biocompatible Materials; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007910:Lenses, Intraocular; D008689:Methacrylates; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D012826:Silicone Elastomers / Q000737:chemistry*; D012827:Silicone Oils / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D012826:Silicone Elastomers; D012827:Silicone Oils; D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine