title: Malignant pleural mesothelioma in a patient with systemic sclerosis: the first report.
abstract: Malignant pleural mesothelioma (MPM) is a relatively rare but aggressive pleural tumor. Systemic sclerosis (SSc) is associated with the development of lung cancer and other malignancies. We describe a 58-year-old never-smoker female, previously diagnosed with limited cutaneous SSc, who presented with chest pain on the left side, dyspnea and circumferential nodular left pleural thickening. Fluorodeoxyglucose positron-emission tomography-computed tomography showed intense uptake in the thickened left pleura, mediastinal lymph nodes and left femur. Pleural fluid cytological examination along with nuclear and membranous positivity for Wilms tumor-1 antigen and epithelial membrane antigen on immunocytochemistry confirmed the diagnosis of MPM. To the best of our knowledge, this is the first report of MPM in a patient with SSc.
authors: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. navneetchd@yahoo.com
authors: Navneet
authors: N
authors: Singh
authors: Karan
authors: K
authors: Madan
authors: Anish
authors: A
authors: Bhattacharya
authors: Raje
authors: R
authors: Nijhawan
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000150:complications / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed