title: The "bone morphogenic proteins" pathways in bone and joint diseases: translational perspectives from physiopathology to therapeutic targets.
abstract: A large body of evidence supports an important role of bone morphogenic proteins (BMPs) pathways in skeletal development in the embryo. BMPs are also involved in skeletal homeostasis and diseases in the adult. They were first identified as major bone anabolic agents and recent advances indicate that they also regulate osteoclastogenesis and joint components via multiple cross-talks with other signaling pathways. This review attempts to integrate these data in the pathogenesis of bone and joints diseases, such as osteoporosis, fracture healing, osteoarthritis, inflammatory arthritis, or bone metastasis. The use of recombinant BMPs in bone tissue engineering and in the treatment of skeletal diseases, or future therapeutic strategies targeting BMPs signal and its regulators, will be discussed based on these considerations.
authors: Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoléon, BP120, 62327 Boulogne sur Mer, France. ebiver@yahoo.fr
authors: Emmanuel
authors: E
authors: Biver
authors: Pierre
authors: P
authors: Hardouin
authors: Joseph
authors: J
authors: Caverzasio
mesh_terms: D000818:Animals; D001168:Arthritis / Q000378:metabolism; D001846:Bone Development; D001847:Bone Diseases / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D001859:Bone Neoplasms / Q000378:metabolism / Q000556:secondary; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism*; D017102:Fracture Healing; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism*; D010024:Osteoporosis / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins