title: Biosignatures: comparative effectiveness research in biomarker clinical studies.
abstract: Due to increased healthcare expenditure and the need for evidence-supported clinical decision-making, clinical evaluation using comparative effectiveness research (CER) was initially proposed in the US. CER consists of generating and synthesizing evidence in relative benefits, harms, and costs of different alternatives through direct head-to-head comparisons. CER studies can help identify the most effective interventions for patients under specific circumstances, and therefore improve the efficiency of the healthcare system. A Biosignatures project newly launched in Taiwan was inspired by CER, aiming at using discovered biomarkers panel as tools in early detection of disease and prediction of treatment effectiveness.
authors: Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan, Taiwan.
authors: Jur-Shan
authors: JS
authors: Cheng
authors: David Bin-Shiun
authors: DB
authors: Wu
authors: Yu Wen
authors: YW
authors: Wen
authors: Pi-Hua
authors: PH
authors: Liu
authors: Jr-Rung
authors: JR
authors: Lin
authors: Chee-Jen
authors: CJ
authors: Chang
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D057186:Comparative Effectiveness Research; D019317:Evidence-Based Medicine; D006801:Humans; D013624:Taiwan
chemical_list: D015415:Biomarkers