title: Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis.
abstract: Indoor residual spraying (IRS) has become an increasingly popular method of insecticide use for malaria control, and many recent studies have reported on its effectiveness in reducing malaria burden in a single community or region. There is a need for systematic review and integration of the published literature on IRS and the contextual determining factors of its success in controlling malaria. This study reports the findings of a meta-regression analysis based on 13 published studies, which were chosen from more than 400 articles through a systematic search and selection process. The summary relative risk for reducing malaria prevalence was 0.38 (95% confidence interval = 0.31-0.46), which indicated a risk reduction of 62%. However, an excessive degree of heterogeneity was found between the studies. The meta-regression analysis indicates that IRS is more effective with high initial prevalence, multiple rounds of spraying, use of DDT, and in regions with a combination of Plasmodium falciparum and P. vivax malaria.
authors: Department of Public Administration, North Carolina Central University, Durham, North Carolina 27707, USA. dkim@nccu.edu
authors: Dohyeong
authors: D
authors: Kim
authors: Kristen
authors: K
authors: Fedak
authors: Randall
authors: R
authors: Kramer
mesh_terms: D006801:Humans; D007306:Insecticides; D008288:Malaria / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D012044:Regression Analysis
chemical_list: D007306:Insecticides