title: An integrated framework for finite-element modeling of mitral valve biomechanics from medical images: application to MitralClip intervention planning.
abstract: Treatment of mitral valve (MV) diseases requires comprehensive clinical evaluation and therapy personalization to optimize outcomes. Finite-element models (FEMs) of MV physiology have been proposed to study the biomechanical impact of MV repair, but their translation into the clinics remains challenging. As a step towards this goal, we present an integrated framework for finite-element modeling of the MV closure based on patient-specific anatomies and boundary conditions. Starting from temporal medical images, we estimate a comprehensive model of the MV apparatus dynamics, including papillary tips, using a machine-learning approach. A detailed model of the open MV at end-diastole is then computed, which is finally closed according to a FEM of MV biomechanics. The motion of the mitral annulus and papillary tips are constrained from the image data for increased accuracy. A sensitivity analysis of our system shows that chordae rest length and boundary conditions have a significant influence upon the simulation results. We quantitatively test the generalization of our framework on 25 consecutive patients. Comparisons between the simulated closed valve and ground truth show encouraging results (average point-to-mesh distance: 1.49 ± 0.62 mm) but also the need for personalization of tissue properties, as illustrated in three patients. Finally, the predictive power of our model is tested on one patient who underwent MitralClip by comparing the simulated intervention with the real outcome in terms of MV closure, yielding promising prediction. By providing an integrated way to perform MV simulation, our framework may constitute a surrogate tool for model validation and therapy planning.
authors: Siemens Corporation, Corporate Research and Technology, Image Analytics and Informatics, Princeton, NJ, USA. tommaso.mansi@siemens.com
authors: Tommaso
authors: T
authors: Mansi
authors: Ingmar
authors: I
authors: Voigt
authors: Bogdan
authors: B
authors: Georgescu
authors: Xudong
authors: X
authors: Zheng
authors: Etienne Assoumou
authors: EA
authors: Mengue
authors: Michael
authors: M
authors: Hackl
authors: Razvan I
authors: RI
authors: Ionasec
authors: Thilo
authors: T
authors: Noack
authors: Joerg
authors: J
authors: Seeburger
authors: Dorin
authors: D
authors: Comaniciu
mesh_terms: D062906:Cardiac Catheters; D003198:Computer Simulation; D019544:Equipment Failure Analysis; D020342:Finite Element Analysis; D006801:Humans; D008943:Mitral Valve / Q000503:physiopathology* / Q000601:surgery*; D058386:Mitral Valve Annuloplasty / Q000295:instrumentation*; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D017755:Prosthesis Fitting; D025321:Surgery, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D013525:Surgical Instruments; D018511:Systems Integration; D016896:Treatment Outcome