title: Reconstruction of full-thickness defects with bovine-derived collagen/elastin matrix: a series of challenging cases and the first reported post-burn facial reconstruction.
abstract: Reconstruction of full-thickness defects may benefit from integration of dermal substitutes, which serve as a foundation for split-thickness skin grafts, thus enhancing short and long-term results. We present a series of 7 patients who were treated between 2010 and 2012 for complicated full-thickness defects by the second-generation collagen/elastin matrix Matriderm® covered by a split-thickness skin graft. The defects resulted from malignancy resection, trauma, and post-burn scar reconstruction. Overall graft take was excellent and no complications were noted regarding the dermal substitute. Graft quality was close to normal skin in terms of elasticity, pliability, texture, and color. Good contour and cushioning of defects in weight bearing areas was also achieved. Matriderm was found to be a useful adjunct to full-thickness defect reconstruction, especially in difficult areas where the desired result is a scar of the highest quality possible.
authors: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.
authors: Josef
authors: J
authors: Haik
authors: Oren
authors: O
authors: Weissman
authors: Gabriel
authors: G
authors: Hundeshagen
authors: Nimrod
authors: N
authors: Farber
authors: Moti
authors: M
authors: Harats
authors: Shira M
authors: SM
authors: Rozenblatt
authors: Lars Peter
authors: LP
authors: Kamolz
authors: Eyal
authors: E
authors: Winkler
authors: Isaac
authors: I
authors: Zilinsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002056:Burns / Q000473:pathology / Q000601:surgery*; D002417:Cattle; D002921:Cicatrix / Q000209:etiology; D003094:Collagen / Q000008:administration & dosage; D004548:Elasticity; D004549:Elastin / Q000008:administration & dosage; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D003094:Collagen; D004549:Elastin