title: [Kidney and bone update : the 5-year history and future of CKD-MBD. The changes after the introduction of CKD-MBD as a new entity].
abstract: Recent clinical studies have indicated that mineral metabolism disorder in chronic kidney disease (CKD) is not a disease confined to bone, but a systemic disease that determine the prognosis by promoting vascular calcification. In the context of this paradigm shift, KDIGO (Kidney Disease : Improving Global Outcomes) introduced a new disease entity "CKD-bone and mineral disorder (MBD) " in 2005, and released clinical practice guideline on the management of CKD-MBD in 2009. This guideline is based on strict systemic evidence review and has had considerable effect on clinical practice. However, on the other hand, it became apparent that only a few clinical studies could support the recommendation of this guideline with high-quality evidence. There is a compelling need for accumulation of clinical findings with high-quality evidence.
authors: Division of Nephrology and Metabolism, Tokai University School of Medicine, Japan.
authors: Masahiro
authors: M
authors: Koizumi
authors: Masafumi
authors: M
authors: Fukagawa
mesh_terms: D002908:Chronic Disease; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000145:classification / Q000209:etiology / Q000628:therapy; D019317:Evidence-Based Medicine; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy; D008903:Minerals / Q000378:metabolism*; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D008903:Minerals