title: Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia.
abstract: Bone marrow samples from children with acute lymphoblastic leukemia were analyzed for the expression of RUNX1a/b/c isoforms. Obtained patterns were associated with genetic abnormalities and the expression of the RUNX1 regulated gene BLK. RUNX1c was present in all patients, but the expected over-expression of RUNX1a was not observed. Over-expression of total RUNT domain isoforms was detected in patients with extra RUNX1 copies, and unexpectedly, in those with t(4;11). Only expression of the total RUNT domain-containing isoforms and BLK presented positive correlation. Results suggest a more complex role of RUNX1 in leukemogenesis than the proposed antagonism between the isoforms.
authors: Laboratorio de Cultivo de Tejidos, Instituto Nacional de Pediatría, México, DF, Mexico.
authors: Oreth
authors: O
authors: Montero-Ruíz
authors: Miguel Angel
authors: MA
authors: Alcántara-Ortigoza
authors: Miguel
authors: M
authors: Betancourt
authors: Rocío
authors: R
authors: Juárez-Velázquez
authors: Humberto
authors: H
authors: González-Márquez
authors: Patricia
authors: P
authors: Pérez-Vera
mesh_terms: D000293:Adolescent; D000595:Amino Acid Sequence; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D020033:Protein Isoforms; C493728:RUNX1 protein, human; D011505:Protein-Tyrosine Kinases