title: Mometasone furoate gel: a novel in-office treatment of recalcitrant postoperative chronic rhinosinusitis.
abstract: OBJECTIVE
  To assess the effect of in-office intranasal application of mometasone furoate (MF) gel in reducing sinonasal mucosal inflammation in patients who have undergone endoscopic sinus surgery (ESS) for chronic rhinosinusitis.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Symptomatic post-ESS patients were evaluated with nasal endoscopy. Sinus mucosa was graded as normal, edematous, polypoid, or with frank polyps (scored as 0, 1, 2, or 3, respectively), and the presence or absence of eosinophilic mucin was noted. MF gel was then applied under endoscopic visualization to sinus mucosa demonstrating signs of inflammation. Patients returned to the clinic for three follow-up visits for nasal endoscopy and mucosal evaluation and, if indicated, retreatment with MF gel.
  
  
  RESULTS
  Sixteen patients were treated with hydrophilic MF gel. The volume and concentrations applied were 2 to 10 cc of 1200 μg/5 cc MF gel (ASL Pharmacy, Camarillo, CA). At the initial visit, the average mucosal score was 2.19 ± 0.16. At follow-up visits 1 and 2, the average mucosal score was 1.44 ± 0.25 (p  =  .01) and 1.38 ± 0.28 (p  =  .03), respectively. There was an observed overall decrease in systemic steroid use.
  
  
  CONCLUSIONS
  In-office endoscopic sinonasal application of MF gel is a useful adjunct to treat mucosal inflammation in postoperative patients with chronic rhinosinusitis. It may help reduce the need for systemic as well as topical steroid therapy.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, University of Texas Medical School at Houston, 77030, USA.
authors: Ibrahim
authors: I
authors: Alava
authors: Seth
authors: S
authors: Isaacs
authors: Amber
authors: A
authors: Luong
authors: Martin J
authors: MJ
authors: Citardi
authors: Samer
authors: S
authors: Fakhri
mesh_terms: D000281:Administration, Intranasal; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011244:Pregnadienediols / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D012220:Rhinitis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D012852:Sinusitis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D005782:Gels; D011244:Pregnadienediols; D000068656:Mometasone Furoate