title: First-trimester maternal serum metastin, placental growth factor and chitotriosidase levels in pre-eclampsia.
abstract: OBJECTIVE
  To investigate whether the serum levels of metastin and PIGF and chitotriosidase activity early in pregnancy differ in women who develop pre-eclampsia from those who remain normotensive.
  
  
  METHODS
  A retrospective case-control study of prospectively collected data. Thirty healthy pregnant women and 31 women with pre-eclampsia were included in the study. Serum samples were collected at 11-14 weeks and stored at -70°C. Levels of metastin, PIGF and chitotriosidase activity were measured in serum from pregnant women with subsequent development of pre-eclampsia and matched controls.
  
  
  RESULTS
  Mean maternal serum metastin (1554 ± 385 pmol/L vs 1995 ± 375 pmol/L, p<0.001) and PIGF (111.9 ± 7.0 pg/mL vs 124.9 ± 3.5 pg/mL, p<0.001) levels were significantly lower and chitotriosidase activity was significantly higher (681.6 ± 248.3 nmol/mL/h vs 527.7 ± 223.1 nmol/mL/h, p<0.01) in women who subsequently developed pre-eclampsia than in those who remained normotensive. The areas under the curve equal to 0.797, 0.831 and 0.681 (p<0.001, p<0.001 and p<0.01) for metastin, PIGF, and chitotriosidase respectively were determined for the prediction of pre-eclampsia.
  
  
  CONCLUSIONS
  Metastin and PIGF levels and chitotriosidase activity are altered in the first trimester serum of women destined to become pre-eclamptic, reflecting placental dysfunction. Metastin, like PIGF, may have a potential to be used as a first-trimester biomarker of pre-eclampsia.
authors: Istanbul University, Cerrahpaşa Medical Faculty, Obstetrics and Gynecology Department, Istanbul, Turkey. madazli@superonline.com
authors: Riza
authors: R
authors: Madazli
authors: Berk
authors: B
authors: Bulut
authors: Abdullah
authors: A
authors: Tuten
authors: Burcu
authors: B
authors: Aydin
authors: Gökhan
authors: G
authors: Demirayak
authors: Mine
authors: M
authors: Kucur
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015536:Down-Regulation; D005260:Female; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D059648:Kisspeptins / Q000097:blood*; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C106628:KISS1 protein, human; D059648:Kisspeptins; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D006596:Hexosaminidases; C086400:chitotriosidase