title: Culture and successful eradication of Helicobacter pylori from heterotopic gastric mucosa.
abstract: Helicobacter pylori colonizes the gastric mucosa of humans and can cause chronic gastritis, peptic ulcer disease, gastric cancer or mucosa-associated-lymphoid tissue (MALT) lymphoma. Here, we report the case of a 61-year-old male patient who presented with tickle of the throat, globus sensation and heartburn. In an esophagogastroduodenoscopy subpharyngeal localized heterotopic gastric mucosa (HGM), reflux esophagitis and a chronic gastritis were diagnosed. HGM and stomach were H. pylori positive as proven by culture and histopathological examination. After eradication therapy with a proton pump inhibitor (PPI), amoxicillin and clarithromycin followed by PPI treatment, the patient reported clinical improvement and the histopathological changes in the HGM due to H. pylori infection improved, too. This case report demonstrates that culture and susceptibility testing of H. pylori using established protocols succeeds not only from tissue samples of the stomach but also from heterotopic gastric mucosa. Eradication therapy may not only improve typical H. pylori associated discomforts of the stomach but also extragastric signs and symptoms of H. pylori infection.
authors: Institute of Medical Microbiology and Hygiene, National Reference Centre for Helicobacter, University Medical Centre Freiburg, Germany. nicole.wueppenhorst@uniklinikfreiburg.de
authors: N
authors: N
authors: Wüppenhorst
authors: B
authors: B
authors: Viebahn
authors: A
authors: A
authors: Theile
authors: H J
authors: HJ
authors: Radü
authors: M
authors: M
authors: Kist
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002828:Choristoma / Q000382:microbiology*; D005753:Gastric Mucosa / Q000382:microbiology*; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors