title: Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.
abstract: Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl,5α,14β-dihydroxy-1α,6α,7β-triacetoxycass-13(15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC₅₀ values from 18.4 to 83.9 µM.
authors: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
authors: Guo-Xu
authors: GX
authors: Ma
authors: Xu-Dong
authors: XD
authors: Xu
authors: Li
authors: L
authors: Cao
authors: Jing-Quan
authors: JQ
authors: Yuan
authors: Jun-Shan
authors: JS
authors: Yang
authors: Li-Yan
authors: LY
authors: Ma
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D029911:Caesalpinia / Q000737:chemistry*; D003603:Cytotoxins / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D004224:Diterpenes; D004365:Drugs, Chinese Herbal