title: Malignancy and chronic leg ulcers: the value of systematic wound biopsies: a prospective, multicenter, cross-sectional study.
abstract: OBJECTIVE
  To determine the frequency of skin cancers associated with chronic leg ulcers (CLUs) presumably of vascular origin and failing to heal (ie, increased wound area or depth) despite 3 months or more of appropriate treatment.
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Ambulatory or hospitalized patients from 17 dermatology departments.
  
  
  METHODS
  Between January 1, 2006, and May 31, 2008, a total of 144 patients consulted for CLUs, attributed to venous and/or peripheral arterial disease(s), increasing in wound size, that is, larger area and/or depth, despite appropriate standard treatment for at least 3 months.
  
  
  METHODS
  At inclusion, at least two 6-mm punch biopsies, 1 at the wound edge and 1 in the wound bed, in the most clinically suspicious areas, were systematically performed. The primary end point was the skin cancer frequency diagnosed in at least 1 wound biopsy specimen obtained at inclusion.
  
  
  RESULTS
  The 144 patients included had 154 CLUs. The overall skin cancer frequency in the CLUs was 10.4%: 9 squamous cell and 5 basal cell carcinomas, 1 melanoma, and 1 leiomyosarcoma; 56.3% had persisted for at least 3 years. Univariate analyses retained older age, abnormal excessive granulation tissue at wound edges, high clinical suspicion of cancer, and number of biopsies, but not wound area or duration, as being significantly associated with skin cancer in 1 or more biopsy specimens.
  
  
  CONCLUSIONS
  The combined primary ulcerated cancer or malignant transformation frequency was sufficiently high in CLUs referred to tertiary care centers to consider systematic biopsy of a wound refractory to 3 months or more of appropriate treatment.
authors: Department of Dermatology, Hopital Tenon, Assistance Publique–Hopitaux de Paris (AP-HP), Universite´ Paris X, Paris, France. patricia.senet@tnn.aphp.fr
authors: Patricia
authors: P
authors: Senet
authors: Patrick
authors: P
authors: Combemale
authors: Clelia
authors: C
authors: Debure
authors: Nathalie
authors: N
authors: Baudot
authors: Laurent
authors: L
authors: Machet
authors: Mounir
authors: M
authors: Aout
authors: Eric
authors: E
authors: Vicaut
authors: Catherine
authors: C
authors: Lok
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000473:pathology*; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D058729:Peripheral Arterial Disease; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors; D014652:Vascular Diseases / Q000150:complications*; D014945:Wound Healing