title: Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia.
abstract: The role of food matrix and gender on soy isoflavone metabolism and biomarkers of activity were examined in twenty free-living adults (34.7 ± 11.5 years old) with hypercholesterolemia (221.9 ± 18.7mg dL(-1)). In a randomized crossover design study, participants consumed soy bread (3 wk) or a soy beverage (3 wk) containing 20 g soy protein with 99 and 93 mg isoflavones aglycone equivalents per day, respectively. During soy bread intervention, women had significantly greater microbial metabolite excretion (P = 0.05) of isoflavonoids than men. In men, isoflavone metabolite excretion was not discernibly different between the two matrices. Significant reductions (P≤ 0.05) in triglycerides (24.8%), LDL cholesterol (6.0%), apolipoprotein A-I (12.3%), and lipid oxidative stress capacity (25.5%), were observed after soy food intervention. Our findings suggest that the food matrix significantly impacts soy isoflavone metabolism, particularly microbial metabolites in women.
authors: Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA.
authors: Jennifer
authors: J
authors: Ahn-Jarvis
authors: Steven K
authors: SK
authors: Clinton
authors: Kenneth M
authors: KM
authors: Riedl
authors: Yael
authors: Y
authors: Vodovotz
authors: Steven J
authors: SJ
authors: Schwartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D004032:Diet; D005260:Female; D019833:Genistein / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000503:physiopathology; D007529:Isoflavones / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D045730:Soy Foods / Q000032:analysis; D030262:Soybean Proteins / Q000032:analysis / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; D008078:Cholesterol, LDL; D007529:Isoflavones; D030262:Soybean Proteins; D014280:Triglycerides; C004742:daidzein; D019833:Genistein