title: Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa.
abstract: We investigated the transcriptional responses of Pseudomonas aeruginosa under phosphate-deficient (0.2 mM) conditions compared to phosphate sufficiency (1 mM). This elicited enormous transcriptional changes in genes related to phosphate acquisition, quorum sensing, chemotaxis, toxin secretion, and regulation. This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity.
authors: Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Manjeet
authors: M
authors: Bains
authors: Lucía
authors: L
authors: Fernández
authors: Robert E W
authors: RE
authors: Hancock
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics; D020869:Gene Expression Profiling; D008124:Locomotion; D010710:Phosphates / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity* / Q000502:physiology*
chemical_list: D001427:Bacterial Toxins; D010710:Phosphates