title: Turning cardiac fibroblasts into cardiomyocytes in vivo.
abstract: Murine fibroblasts have previously been reprogrammed to form cardiomyocytes in vitro, but recent studies have demonstrated direct conversion of cardiac fibroblasts into cardiomyocytes in vivo. This is accomplished by delivering transcription factors or microRNAs to the mouse heart and may represent a new avenue for regenerative cardiac therapy.
authors: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. chunhui.xu@emory.edu
authors: Chunhui
authors: C
authors: Xu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005347:Fibroblasts / Q000166:cytology*; D050991:GATA4 Transcription Factor / Q000235:genetics / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D064326:MEF2 Transcription Factors; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D017570:MyoD Protein / Q000235:genetics / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000166:cytology*; D018006:Myogenic Regulatory Factors / Q000235:genetics / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000235:genetics / Q000378:metabolism; D055748:SOXB1 Transcription Factors / Q000235:genetics / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D050991:GATA4 Transcription Factor; C484171:Gata4 protein, mouse; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D064326:MEF2 Transcription Factors; C578041:Mef2c protein, mouse; D035683:MicroRNAs; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D018006:Myogenic Regulatory Factors; D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D055748:SOXB1 Transcription Factors; C527783:Sox2 protein, mouse; D020825:T-Box Domain Proteins; C103172:T-box transcription factor 5; D014157:Transcription Factors