title: Tandem ring-opening decarboxylation of cyclopropane hemimalonates with sodium azide: a short route to γ-aminobutyric acid esters.
abstract: Cyclopropane hemimalonates, when treated with sodium azide, undergo a tandem ring-opening decarboxylation to produce γ-azidobutyric acids in good yields. These adducts were hydrogenated to form γ-aminobutyric acid (GABA) methyl esters.
authors: Department of Chemistry, Western University, London, Ontario, Canada N6A 5B7.
authors: Michael R
authors: MR
authors: Emmett
authors: Huck K
authors: HK
authors: Grover
authors: Michael A
authors: MA
authors: Kerr
mesh_terms: D003521:Cyclopropanes / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D019810:Sodium Azide / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D003521:Cyclopropanes; C037739:4-aminobutyric acid methyl ester; D005680:gamma-Aminobutyric Acid; D019810:Sodium Azide