title: IRF-1 is critical for IFNγ mediated immune surveillance.
abstract: We recently described that IRF-1 is important for IFNγ mediated immune surveillance in metastasis. Despite the upregulation of MHC Class I in tumor cells, IRF-1 leads to a NK cell-dependent elimination of tumor cells. This mechanism is independent on inhibitory receptors and cytotoxic granules but dependent on DNAM-1.
authors: Fraunhofer Institute for Cell Therapy and Immunology; Leipzig, Germany.
authors: Antje
authors: A
authors: Ksienzyk
authors: Berit
authors: B
authors: Neumann
authors: Andrea
authors: A
authors: Kröger