title: Post-transcriptional control of type I interferon induction by porcine reproductive and respiratory syndrome virus in its natural host cells.
abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.
authors: Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA. xiuqing.wang@sdstate.edu
authors: Xiuqing
authors: X
authors: Wang
authors: Jane
authors: J
authors: Christopher-Hennings
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D057131:Immune Evasion; D007370:Interferon Type I / Q000096:biosynthesis* / Q000276:immunology; D011070:Poly I-C / Q000276:immunology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology / Q000472:pathogenicity*; D014176:Protein Biosynthesis; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology
chemical_list: D007370:Interferon Type I; D011070:Poly I-C