title: Increased ratio of soluble fibrin formation/thrombin generation in patients with DIC.
abstract: The generation of thrombin-antithromin (AT) complex (TAT) or soluble fibrin (SF) was prospectively compared with prothrombin fragment 1 + 2 (F1 + 2) generation in patients with disseminated intravascular coagulation (DIC). The plasma levels of TAT, SF, and F1 + 2 were significantly higher in the DIC group than in the non-DIC group. The differences in these levels between the DIC group and non-DIC group were significantly related to infections and hematopoietic tumors. There were no significant differences in the TAT/F1 + 2 ratio between DIC and non-DIC patients, but the SF/F1 + 2 ratio was significantly higher in the DIC group than the non-DIC group. The plasma AT activity was significantly higher in patients with DIC with resolution than in those without resolution, and in survivors than in nonsurvivors. These findings suggest that the ratio of TAT/thrombin is constant between the patients with and without DIC but that the ratio of fibrin formation/thrombin might increase in DIC.
authors: Division of Emergency Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Shigeki
authors: S
authors: Kushimoto
authors: Hideo
authors: H
authors: Wada
authors: Kazuo
authors: K
authors: Kawasugi
authors: Kohji
authors: K
authors: Okamoto
authors: Toshimasa
authors: T
authors: Uchiyama
authors: Yoshinobu
authors: Y
authors: Seki
authors: Tsuyoshi
authors: T
authors: Hatada
authors: Hiroshi
authors: H
authors: Imai
authors: Tsutomu
authors: T
authors: Nobori
mesh_terms: D000368:Aged; D000990:Antithrombin III; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood*; D013917:Thrombin / Q000378:metabolism*
chemical_list: C046193:antithrombin III-protease complex; D000990:Antithrombin III; D005337:Fibrin; D010447:Peptide Hydrolases; D013917:Thrombin