title: Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men.
abstract: OBJECTIVE
  Considerable interest and controversy over a possible decline in semen quality during the 20th century raised concern that semen quality could have reached a critically low level where it might affect human reproduction. The authors therefore initiated a study to assess reproductive health in men from the general population and to monitor changes in semen quality over time.
  
  
  METHODS
  Cross-sectional study of men from the general Danish population. Inclusion criteria were place of residence in the Copenhagen area, and both the man and his mother being born and raised in Denmark. Men with severe or chronic diseases were not included.
  
  
  METHODS
  Danish one-centre study.
  
  
  METHODS
  4867 men, median age 19 years, included from 1996 to 2010.
  
  
  METHODS
  Semen volume, sperm concentration, total sperm count, sperm motility and sperm morphology.
  
  
  RESULTS
  Only 23% of participants had optimal sperm concentration and sperm morphology. Comparing with historic data of men attending a Copenhagen infertility clinic in the 1940s and men who recently became fathers, these two groups had significantly better semen quality than our study group from the general population. Over the 15 years, median sperm concentration increased from 43 to 48 million/ml (p=0.02) and total sperm count from 132 to 151 million (p=0.001). The median percentage of motile spermatozoa and abnormal spermatozoa were 68% and 93%, and did not change during the study period.
  
  
  CONCLUSIONS
  This large prospective study of semen quality among young men of the general population showed an increasing trend in sperm concentration and total sperm count. However, only one in four men had optimal semen quality. In addition, one in four will most likely face a prolonged waiting time to pregnancy if they in the future want to father a child and another 15% are at risk of the need of fertility treatment. Thus, reduced semen quality seems so frequent that it may impair the fertility rates and further increase the demand for assisted reproduction.
authors: University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors: Niels
authors: N
authors: Jørgensen
authors: Ulla Nordström
authors: UN
authors: Joensen
authors: Tina Kold
authors: TK
authors: Jensen
authors: Martin Blomberg
authors: MB
authors: Jensen
authors: Kristian
authors: K
authors: Almstrup
authors: Inge Ahlmann
authors: IA
authors: Olesen
authors: Anders
authors: A
authors: Juul
authors: Anna-Maria
authors: AM
authors: Andersson
authors: Elisabeth
authors: E
authors: Carlsen
authors: Jørgen Holm
authors: JH
authors: Petersen
authors: Jorma
authors: J
authors: Toppari
authors: Niels E
authors: NE
authors: Skakkebæk