title: Efficacy of Olibra: a 12-week randomized controlled trial and a review of earlier studies.
abstract: BACKGROUND
  Intervention strategies that harness the body's appetite and satiety regulating signals provide a means of countering excessive energy intake.
  
  
  METHODS
  Eighty-two subjects were enrolled (18-60 years, body mass index: 25-40 kg/m(2)) in a randomized, placebo-controlled, double-blind, parallel trial. During a 12-week period, the effects of Olibra™ fat emulsion (2.1 g twice daily) on food intake, appetite, satiety, weight, and body composition were compared with those of a twice daily administered placebo (1.95 g milk fat). On days -7, 0, and 28, Olibra or the placebo added to 200 g of yogurt was served at breakfast and lunch. Food intake, appetite, and satiety were assessed after lunch and dinner. Body weight was measured on days -7, 0, 14, 28, 56, and 84. Body fat, waist circumference, and waist-hip ratio were determined on days 0 and 84. The Eating Inventory was administered at screening and on day 28. Data relating to 71 subjects were analyzed using analysis of covariance.
  
  
  RESULTS
  At 12 weeks, body weight was reduced in the test group (2.17 ± 0.46 kg standard error of the mean, p < .0001) and the control group (1.68 ± 0.42 kg, p < .0001). Waist circumference decreased by 2.93 ± 0.85 cm in the test group (p = .001) and by 1.78 ± 0.74 cm in the control group (p = .02). Differential weight and waist circumference reductions were not significant. Hunger scores (Eating Inventory) decreased more in the test group (p = .0082). Differential group effects were not significant for body fat, waist-hip ratio, food intake, appetite, and satiety.
  
  
  CONCLUSIONS
  At this dose, Olibra did not exert a consistent effect on food intake, appetite regulation, body weight, or body composition.
authors: Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
authors: Candida J
authors: CJ
authors: Rebello
authors: Corby K
authors: CK
authors: Martin
authors: William D
authors: WD
authors: Johnson
authors: Carol E
authors: CE
authors: O'Neil
authors: Frank L
authors: FL
authors: Greenway
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001069:Appetite Regulation / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D016009:Chi-Square Distribution; D004041:Dietary Fats / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects; D004655:Emulsions / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008145:Louisiana; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D012528:Satiety Response / Q000187:drug effects; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D004041:Dietary Fats; D004655:Emulsions