title: Action of a serotonergic anorectic in meal-fed mice working for food.
abstract: The aim of this study was to examine the effects of a serotonergic anorectic agent, dexnorfenfluramine (DNOR), on food intake in mice whose meals were constrained to specified periods each day and by effort. Mice were forced to adopt a human-like pattern of regular meals by making food available for four periods of 40 min/24-h period, mostly at night. They lived in behavior test chambers with a closed economy for food and were required to emit a fixed unit price (FUP) of either 2 or 25 nose pokes (FUP2, FUP25) to receive a 20 mg pellet of food. Once responding and intake were stable, mice were injected with a vehicle or DNOR (3 or 6 mg/kg) 1 h before a specified feeding opportunity. Food intake was dose-dependently suppressed at the next meal and to a greater extent when the cost of food was high (FUP25). Within a meal, the effect of the drug was the greatest in the first half of the available time. Therefore, the anorectic effect of DNOR was modified by the concurrent cost of food.
authors: Department of Psychology, University of Florida, Gainesville, Florida 32611-2250, USA. nrowland@ufl.edu
authors: Neil E
authors: NE
authors: Rowland
authors: Kimberly L
authors: KL
authors: Robertson
authors: Emilia M
authors: EM
authors: Cadiz
authors: Jessica
authors: J
authors: Kenney
authors: Veronica
authors: V
authors: Kwiatkowski
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D062407:Meals; D051379:Mice; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009642:Norfenfluramine / Q000494:pharmacology*; D044405:Receptor, Serotonin, 5-HT2C / Q000737:chemistry / Q000378:metabolism; D012201:Reward; D012528:Satiety Response / Q000187:drug effects*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001067:Appetite Depressants; D009419:Nerve Tissue Proteins; D044405:Receptor, Serotonin, 5-HT2C; D058830:Serotonin 5-HT2 Receptor Antagonists; D009642:Norfenfluramine