title: A novel and facile synthetic approach for tasigna.
abstract: A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40%). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.
authors: School of Medicine, Xi'an Jiaotong University, No. 76, Yanta West Road, Xi'an, Shaanxi Province, 710061, PR China.
authors: Xiaoyan
authors: X
authors: Pan
authors: Wen
authors: W
authors: Lu
authors: Pengfei
authors: P
authors: Li
authors: Fang
authors: F
authors: Wang
authors: Chen
authors: C
authors: Wang
authors: Zhigang
authors: Z
authors: Hu
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors / Q000737:chemistry; D055772:Green Chemistry Technology; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D003300:Copper; D011505:Protein-Tyrosine Kinases; D016044:Fusion Proteins, bcr-abl; C498826:nilotinib