title: Evaluation of antileishmanial activity of South Indian medicinal plants against Leishmania donovani.
abstract: Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The aim of this study was to evaluate the in vitro antileishmanial activity of the acetone and methanol leaf extracts of Anisomeles malabarica, flower of Gloriosa superba, leaf of Ocimum basilicum, leaf and seed of Ricinus communis against promastigotes form of Leishmania donovani. Antiparasitic evaluations of different plant crude extracts were performed on 96 well plates at 37°C for 24-48 h. Out of the 10 experimental plant extracts tested, the leaf methanol extracts of A. malabarica, and R. communis showed good antileishmanial activity (IC(50)=126±19.70 and 184±39.33 μg/mL), respectively against promastigotes. Effective antileishmanial activity was observed making these plants as good candidates for isolation of antiprotozoal compounds which could serve as new lead structures for drug development.
authors: Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam 632 509, Vellore District, Tamil Nadu, India.
authors: Abdul Abduz
authors: AA
authors: Zahir
authors: Abdul Abdul
authors: AA
authors: Rahuman
authors: Sourav
authors: S
authors: Pakrashi
authors: Debopam
authors: D
authors: Ghosh
authors: Asokan
authors: A
authors: Bagavan
authors: Chinnaperumal
authors: C
authors: Kamaraj
authors: Gandhi
authors: G
authors: Elango
authors: Mitali
authors: M
authors: Chatterjee
mesh_terms: D004305:Dose-Response Relationship, Drug; D035264:Flowers / Q000737:chemistry; D007194:India; D019686:Lamiaceae / Q000737:chemistry; D007893:Leishmania donovani / Q000187:drug effects*; D019668:Liliaceae / Q000737:chemistry; D018649:Ocimum basilicum / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012278:Ricinus / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D010936:Plant Extracts