title: From cis-regulatory elements to complex RNPs and back.
abstract: Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These elements are frequently located in the untranslated regions and serve as binding sites for trans-acting factors, RNA-binding proteins, and/or small non-coding RNAs. This article provides a systematic synopsis of cis-acting elements, trans-acting factors, and the mechanisms by which they affect translation. It also highlights recent technical advances that have ushered in the era of transcriptome-wide studies of the ribonucleoprotein complexes formed by mRNAs and their trans-acting factors.
authors: Gene Regulation Programme, Centre for Genomic Regulation (CRG) and UPF, 08003-Barcelona, Spain. fatima.gebauer@crg.eu
authors: Fátima
authors: F
authors: Gebauer
authors: Thomas
authors: T
authors: Preiss
authors: Matthias W
authors: MW
authors: Hentze
mesh_terms: D001665:Binding Sites; D002846:Chromatography, Affinity; D005786:Gene Expression Regulation; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D012261:Ribonucleoproteins / Q000378:metabolism*; D020506:Untranslated Regions
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; D020506:Untranslated Regions