title: Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.
abstract: In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n = 10 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit β-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and α-tocopherol in the liver. An age-dependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice.
authors: Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Hermann Rodewald Strasse 6, 24098, Kiel, Germany.
authors: Banu
authors: B
authors: Bayram
authors: Sibylle
authors: S
authors: Nikolai
authors: Patricia
authors: P
authors: Huebbe
authors: Beraat
authors: B
authors: Ozcelik
authors: Stefanie
authors: S
authors: Grimm
authors: Tilman
authors: T
authors: Grune
authors: Jan
authors: J
authors: Frank
authors: Gerald
authors: G
authors: Rimbach
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000502:physiology*; D010641:Phenotype; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D046988:Proteasome Endopeptidase Complex