title: Meta analysis on the relationship between gene polymorphisms of vascular endothelial growth factor and retinal prognosis risk of prematurity.
abstract: OBJECTIVE
  To explore the relationship between gene polymorphisms of vascular endothelial growth factor (VEGF) and retinopathy of prematurity (ROP).
  
  
  METHODS
  Literature materials related to gene polymorphisms of VEGF and ROP in PubMed, EMBASE, Cochrane and CBM database were retrieved. These materials were screened according to inclusion and exclusion standards. Patients diagnosed with ROP in clinic were regarded as control group and ROP patients who were in treatment were regarded as observation group. The indexes in two groups were matched except birth weight (BW), gender and gestational weeks. Meta5.1 was used to analyze the relationship between gene polymorphisms of VEGF and ROP.
  
  
  RESULTS
  Four random control tests (RCT) were included in this research, including 2611 patients. Meta analysis results showed that VEGF affected ROP, having statistical significance. The combined ratio was 0.44 (95%CI, 0.07, 0.80), 0.42 (95%CI, 0.09, 0.74) and 0.75 (95%CI, 0.02, 1.49), respectively. Carrying +405 allele might increase the premature infants' risk of having ROP.
  
  
  CONCLUSIONS
  ROP may be related to its carrying of +405 allele. Large-scale, multi-factor RCT researches are still needed in order to identify the relation between VEGF and ROP.
authors: Reproductive Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
authors: Jun
authors: J
authors: Zhai
authors: Qiu-Hui
authors: QH
authors: Jiang
authors: Chun-Xi
authors: CX
authors: Liu
authors: Zuo-Rong
authors: ZR
authors: Tian
authors: Ying-Pu
authors: YP
authors: Sun