title: [Establishment of a rat model of low calcium diet related hyperoxaluria].
abstract: OBJECTIVE
  To establish a rat model of low calcium diet related hyperoxaluria and explore its features.
  
  
  METHODS
  By means of randomized blocks design, totally 24 SD male rats were divided into low calcium diet group, medium calcium diet group, and high calcium diet group. Each group was sequentially fed on different calcium diets for 3 days. The urinary volume within 24 hours was recorded, the consistency of urinary oxalate by high-efficiency liquid chromatography, and the consistency of urine creatinine by automatic biochemical analyzer. The consistency was corrected to the output of urinary oxalate of rats in 24 hours, and the results were evaluated by repeated measurement of variance analysis and multivariate analysis of variance.
  
  
  RESULTS
  The output of urinary oxalate of rats in 24 hours varied with time (F=7.893, P0.05). The output of urinary oxalate of rats in 24 hours varied with group division (F=3.565, P<0.05). The output of urinary oxalate in 24 hours in three groups on the third day was significantly higher than that on the first day (P<0.05).
  
  
  CONCLUSIONS
  By controlling the calcium intake, we successfully established the model of low calcium diet related hyperoxaluria in rat.
authors: Nanjing University, Nanjing, China.
authors: Jing
authors: J
authors: Tian
authors: Hong-qian
authors: HQ
authors: Guo
authors: Xi-zhao
authors: XZ
authors: Sun
authors: Ze-yu
authors: ZY
authors: Sun
authors: De-sheng
authors: DS
authors: Lu
mesh_terms: D000818:Animals; D002119:Calcium Carbonate / Q000008:administration & dosage*; D004032:Diet; D004195:Disease Models, Animal; D006959:Hyperoxaluria / Q000209:etiology / Q000652:urine; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002119:Calcium Carbonate