title: Early versus late hCG administration to trigger ovulation in mild stimulated IUI cycles: a randomized clinical trial.
abstract: OBJECTIVE
  To verify non-inferiority of the clinical pregnancy rate of Early hCG administration (leading follicle sizes within 16.0-16.9 mm in diameter) compared to Late hCG administration (leading follicle sizes within 18.0-18.9 mm in diameter).
  
  
  METHODS
  Prospective randomized trial. Six hundred and twelve infertile women candidates for intrauterine insemination (IUI) received HP-hMG 75 IU/day SC from cycle days 4 to 8 and then as per ovarian response. Ovulation was randomly triggered (hCG 5000 IU, IM) when the leading follicle diameter ranged between either 16.0 and 16.9 mm (Early hCG group, n=227) or 18.0 and 18.9 mm (Late hCG group, n=207) and IUI was performed approximately 36 h later.
  
  
  RESULTS
  Whereas population and sperm characteristics were comparable in both groups, the number of follicles ≥ 14 mm in diameter (P<0.007) and serum estradiol levels (P<0.001) on the day of hCG were lower in the Early versus the Late hCG groups. Clinical (11.9% versus 12.1%) and ongoing (11.0% versus 8.6%) pregnancy rates per randomized women were similar in the two groups and statistical non-inferiority of clinical and ongoing pregnancy rates was demonstrated.
  
  
  CONCLUSIONS
  These results suggest that hCG administered when the largest follicle size reaches 16.0-16.9 mm leads to similar clinical and ongoing pregnancy rates as when it reaches 18.0-18.9 mm in IUI cycles.
authors: AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, F-92141, France.
authors: Ana Luisa B
authors: AL
authors: da Silva
authors: Elisangela
authors: E
authors: Arbo
authors: Renato
authors: R
authors: Fanchin
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007246:Infertility / Q000097:blood / Q000628:therapy; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D008596:Menotropins / Q000494:pharmacology; D009866:Oogenesis / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D013810:Therapeutic Equivalency; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D004958:Estradiol; D008596:Menotropins