title: Utility of hepatocyte nuclear factor-1β as a diagnostic marker in ovarian carcinomas with clear cells.
abstract: OBJECTIVE
  Overexpression of hepatocyte nuclear factor-1β (HNF-1β) has been found in ovarian clear cell carcinoma (OCCC) but not in other types of ovarian carcinoma. The aim of this study was to clarify whether the overexpression of HNF-1β is specific for OCCC, and does not occur in ovarian carcinoma with clear cell change.
  
  
  RESULTS
  Immunohistochemistry was performed on 178 ovarian carcinomas with clear cells (80 OCCCs, 60 high-grade serous, 25 endometrioid, and 13 mixed endometrioid and clear cell), 22 ovarian high-grade serous carcinomas without clear cells, 41 renal cell carcinomas (RCCs) and 20 hepatocellular carcinomas (HCCs) with clear cytoplasm. Results were evaluated using an H-score (percentage × intensity). Most OCCCs were diffusely and strongly positive (mean H-score 15.1). High-grade serous carcinoma and endometrioid carcinoma with clear cells were usually negative or focally and weakly positive (mean H-scores 1.5 and 1.7, respectively). High-grade serous carcinoma without clear cells had a mean H-score of 0.77. The mean H-scores of the endometrioid and clear cell components in mixed endometrioid and clear cell carcinoma were 6.2 and 15.7, respectively. HNF-1β was expressed in 95.1% of RCCs and in 30% of HCCs.
  
  
  CONCLUSIONS
  The diagnosis of ovarian carcinomas with clear cells can be made with greater accuracy by using the intensity and extent of immunoreactivity for HNF-1β.
authors: Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Yu-Chien
authors: YC
authors: Kao
authors: Ming-Chieh
authors: MC
authors: Lin
authors: Wei-Chou
authors: WC
authors: Lin
authors: Yung-Ming
authors: YM
authors: Jeng
authors: Tsui-Lien
authors: TL
authors: Mao
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D005260:Female; D051539:Hepatocyte Nuclear Factor 1-beta / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C496495:HNF1B protein, human; D051539:Hepatocyte Nuclear Factor 1-beta