title: Guanacastane-type diterpenoids with cytotoxic activity from Coprinus plicatilis.
abstract: Four new guanacastane-type diterpenoids (1-4), together with the known compound, guanacastepene E (5), were isolated from a basidiomycete of the macro-fungi, Coprinus plicatilis 82. Their structures were elucidated on the basis of extensive spectroscopic analyses, including FT-ICR-MS, UV, IR and 1D and 2D NMR experiments. The in vitro cytotoxic activities of all compounds against the human cancer cell lines HepG2, HeLa, MDA-MB-231, BGC-823, HCT 116, and U2OS were evaluated, only compound 1 exhibited significant cytotoxicities with IC(50) values ranging from 1.2 to 6.0 μM.
authors: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, PR China.
authors: Yuanzhen
authors: Y
authors: Liu
authors: Yaoyao
authors: Y
authors: Li
authors: Yixin
authors: Y
authors: Ou
authors: Shuyan
authors: S
authors: Xiao
authors: Chunhua
authors: C
authors: Lu
authors: Zhonghui
authors: Z
authors: Zheng
authors: Yuemao
authors: Y
authors: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D003302:Coprinus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C516935:guanacastepene E