title: Tau protein kinases: involvement in Alzheimer's disease.
abstract: Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby might contribute to tau aggregation. Thus, understanding the regulation modes of tau phosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates in order to elaborate protection strategies to cope with these lesions in Alzheimer's disease. Among the possible and specific interventions that reverse tau phosphorylation is the inhibition of certain tau kinases. Here, we extensively reviewed tau protein kinases, their physiological roles and regulation, their involvement in tau phosphorylation and their relevance to AD. We also reviewed the most common inhibitory compounds acting on each tau kinase.
authors: Groupe de Neurobiologie Cellulaire - Homéostasie cellulaire et pathologies, Faculté de Médecine, Limoges, France. lmartin.phd@gmail.com
authors: Ludovic
authors: L
authors: Martin
authors: Xenia
authors: X
authors: Latypova
authors: Cornelia M
authors: CM
authors: Wilson
authors: Amandine
authors: A
authors: Magnaudeix
authors: Marie-Laure
authors: ML
authors: Perrin
authors: Catherine
authors: C
authors: Yardin
authors: Faraj
authors: F
authors: Terro
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D000818:Animals; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D038461:Proline-Directed Protein Kinases / Q000235:genetics / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D016875:tau Proteins; D011505:Protein-Tyrosine Kinases; D038461:Proline-Directed Protein Kinases; D038362:Glycogen Synthase Kinase 3; C080888:tau-protein kinase