title: High specificity of combined narrow band imaging and autofluorescence mucosal assessment of patients with head and neck cancer.
abstract: BACKGROUND
  The purpose of this study was to evaluate combined autofluorescence (AF) and narrow band imaging (NBI) for detection of mucosal lesions additional to known primary head and neck cancers and to determine impact on management.
  
  
  METHODS
  Patients with head and neck cancer requiring preoperative screening or posttreatment surveillance had white light (WL), AF and NBI inspection of the head and neck and bronchus. Known primary cancers were not analyzed, only additional lesions. Moderate dysplasia or worse was considered significant.
  
  
  RESULTS
  In all, 73 patients were recruited. Respectively, there were 24 and 18 additional lesions in the head and neck and bronchus that had significant histopathology. In both regions, AF and NBI were more sensitive than WL for detecting significant dysplasia with NBI demonstrating better specificity than AF (p = .003); 11 of 73 patients (15.1%) had additional findings detected by AF and NBI, which had an impact on management.
  
  
  CONCLUSIONS
  Combined AF and NBI inspection is highly specific at panendoscopy and can influence management.
authors: Department of Thoracic Medicine, The Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. phan.nguyen@internode.on.net
authors: Phan
authors: P
authors: Nguyen
authors: Farzad
authors: F
authors: Bashirzadeh
authors: Robert
authors: R
authors: Hodge
authors: Julie
authors: J
authors: Agnew
authors: Camile S
authors: CS
authors: Farah
authors: Edwina
authors: E
authors: Duhig
authors: Belinda
authors: B
authors: Clarke
authors: Joanna
authors: J
authors: Perry-Keene
authors: David
authors: D
authors: Botros
authors: Ian Brent
authors: IB
authors: Masters
authors: David
authors: D
authors: Fielding
mesh_terms: D000368:Aged; D001980:Bronchi / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D062048:Narrow Band Imaging / Q000379:methods; D009362:Neoplasm Metastasis; D061848:Optical Imaging; D012680:Sensitivity and Specificity; D000077195:Squamous Cell Carcinoma of Head and Neck