title: P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.
abstract: The control of translation and mRNA degradation is important in the regulation of eukaryotic gene expression. In general, translation and steps in the major pathway of mRNA decay are in competition with each other. mRNAs that are not engaged in translation can aggregate into cytoplasmic mRNP granules referred to as processing bodies (P-bodies) and stress granules, which are related to mRNP particles that control translation in early development and neurons. Analyses of P-bodies and stress granules suggest a dynamic process, referred to as the mRNA Cycle, wherein mRNPs can move between polysomes, P-bodies and stress granules although the functional roles of mRNP assembly into higher order structures remain poorly understood. In this article, we review what is known about the coupling of translation and mRNA degradation, the properties of P-bodies and stress granules, and how assembly of mRNPs into larger structures might influence cellular function.
authors: Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, Arizona 85721-0206, USA.
authors: Carolyn J
authors: CJ
authors: Decker
authors: Roy
authors: R
authors: Parker
mesh_terms: D003594:Cytoplasmic Granules / Q000378:metabolism; D005786:Gene Expression Regulation; D008957:Models, Genetic; D010442:Peptide Chain Initiation, Translational; D014176:Protein Biosynthesis / Q000502:physiology*; D020871:RNA Stability / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein