title: Genotoxicity evaluation for single-walled carbon nanotubes in a battery of in vitro and in vivo assays.
abstract: The genotoxicity of single-walled carbon nanotubes (SWCNTs) was determined using a battery of genotoxicity assays, comprising a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test and a mammalian erythrocytes micronucleus test. SWCNTs had no mutagenicity in S. typhimurium TA98, TA100, TA1535 or TA1537, or in E. coli WP2uvrA, in the absence or presence of metabolic activation. SWCNTs did not increase the number of structural or numerical chromosomal aberrations after short-term or continuous exposure. In the micronucleus test using CD-1 mice, SWCNTs did not affect the proportion of immature erythrocytes, the total proportion of erythrocytes or the number of micronuclei in immature erythrocytes. SWCNTs appear not to pose a genotoxic risk.
authors: Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, 305-8569, Japan. ema-makoto@aist.go.jp
authors: Makoto
authors: M
authors: Ema
authors: Tadashi
authors: T
authors: Imamura
authors: Hiroshi
authors: H
authors: Suzuki
authors: Norihiro
authors: N
authors: Kobayashi
authors: Masato
authors: M
authors: Naya
authors: Junko
authors: J
authors: Nakanishi
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000235:genetics; D002460:Cell Line; D002869:Chromosome Aberrations / Q000187:drug effects; D006224:Cricetinae; D004249:DNA Damage / Q000187:drug effects*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000493:pharmacokinetics* / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D009153:Mutagens; D037742:Nanotubes, Carbon