title: Optimization of shunt placement for the Norwood surgery using multi-domain modeling.
abstract: An idealized systemic-to-pulmonary shunt anatomy is parameterized and coupled to a closed loop, lumped parameter network (LPN) in a multidomain model of the Norwood surgical anatomy. The LPN approach is essential for obtaining information on global changes in cardiac output and oxygen delivery resulting from changes in local geometry and physiology. The LPN is fully coupled to a custom 3D finite element solver using a semi-implicit approach to model the heart and downstream circulation. This closed loop multidomain model is then integrated with a fully automated derivative-free optimization algorithm to obtain optimal shunt geometries with variable parameters of shunt diameter, anastomosis location, and angles. Three objective functions: (1) systemic; (2) coronary; and (3) combined systemic and coronary oxygen deliveries are maximized. Results show that a smaller shunt diameter with a distal shunt-brachiocephalic anastomosis is optimal for systemic oxygen delivery, whereas a more proximal anastomosis is optimal for coronary oxygen delivery and a shunt between these two anatomies is optimal for both systemic and coronary oxygen deliveries. Results are used to quantify the origin of blood flow going through the shunt and its relationship with shunt geometry. Results show that coronary artery flow is directly related to shunt position.
authors: Mechanical and Aerospace Engineering, University of California San Diego, San Diego, CA 92093, USA. mesmaily@ucsd.edu
authors: Mahdi Esmaily
authors: ME
authors: Moghadam
authors: Francesco
authors: F
authors: Migliavacca
authors: Irene E
authors: IE
authors: Vignon-Clementel
authors: Tain-Yen
authors: TY
authors: Hsia
authors: Alison L
authors: AL
authors: Marsden
mesh_terms: D001775:Blood Circulation; D002302:Cardiac Output; D003331:Coronary Vessels / Q000502:physiology; D008168:Lung / Q000098:blood supply; D008954:Models, Biological; D058327:Norwood Procedures / Q000379:methods*; D010100:Oxygen / Q000378:metabolism; D011312:Pressure; D013314:Stress, Mechanical
chemical_list: D010100:Oxygen