title: Microglia and intractable chronic pain.
abstract: Many pathological processes within the central nervous system are mediated by complex interactions between neurons and resident glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. Purinergic signaling has been shown to be at the center of this reactivity, and here we review recent mechanistic advances describing the importance of microglial P2 receptors and their interactions with neuronal populations in the development of neuropathic pain.
authors: Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Makoto
authors: M
authors: Tsuda
authors: Simon
authors: S
authors: Beggs
authors: Michael W
authors: MW
authors: Salter
authors: Kazuhide
authors: K
authors: Inoue
mesh_terms: D000818:Animals; D006801:Humans; D017628:Microglia / Q000378:metabolism*; D010148:Intractable Pain / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018048:Receptors, Purinergic P2 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology
chemical_list: D018048:Receptors, Purinergic P2