title: The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum.
abstract: Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.
authors: Molecular Parasitology Laboratory, Infectious Diseases Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
authors: Hong
authors: H
authors: You
authors: Geoffrey N
authors: GN
authors: Gobert
authors: Mary G
authors: MG
authors: Duke
authors: Wenbao
authors: W
authors: Zhang
authors: Yuesheng
authors: Y
authors: Li
authors: Malcolm K
authors: MK
authors: Jones
authors: Donald P
authors: DP
authors: McManus
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D011972:Receptor, Insulin / Q000502:physiology*; D012549:Schistosoma japonicum / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000517:prevention & control*; D014612:Vaccines / Q000276:immunology*; D015047:Zoonoses
chemical_list: D000909:Antibodies, Helminth; D014612:Vaccines; D011972:Receptor, Insulin