title: Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and Pluronic F127.
abstract: We synthesized statistical poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T(tr). A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37 °C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics.
authors: Institute of Macromolecular Chemistry ASCR, vvi, Prague 6, Czech Republic.
authors: Jirří
authors: J
authors: Pánek
authors: Sergey K
authors: SK
authors: Filippov
authors: Martin
authors: M
authors: Hrubý
authors: Maria
authors: M
authors: Rabyk
authors: Anna
authors: A
authors: Bogomolova
authors: Jan
authors: J
authors: Kučka
authors: Petr
authors: P
authors: Stěpánek
mesh_terms: D002151:Calorimetry; D007457:Iodine Radioisotopes / Q000737:chemistry; D007553:Isotope Labeling; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging; D010080:Oxazoles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011877:Radionuclide Imaging; D044366:Transition Temperature
chemical_list: D007457:Iodine Radioisotopes; D008823:Micelles; D010080:Oxazoles; C577913:poly(2-oxazoline); D020442:Poloxamer