title: Multifocal histiocytic sarcoma of the gastrointestinal tract.
abstract: We report a rare case of extranodal histiocytic sarcoma with multifocal gastrointestinal tract involvement, which has not been documented in the literature so far. A diagnosis of interdigitating dendritic cell/ histiocytic sarcoma was made on the preoperative gastric biopsy. Computed tomography scan revealed multifocal, circumferential gastrointestinal wall thickening involving the stomach and jejunal loops. Patient underwent distal gastrectomy with extended D1 dissection and proximal jejunal resection with gastrojejunostomy. Immunohistochemistry profile of both the gastric and jejunal tumors was similar to the preoperative gastric biopsy. The histiocytic origin of the tumor was confirmed by positive reaction of the tumor cells for CD 163. She received four cycles of CHOP chemotherapy, and is free of disease three years, following surgery.
authors: Department of Pathology, Cancer Institute (W.I.A.), Chennai, India.
authors: Shirley
authors: S
authors: Sundersingh
authors: Urmila
authors: U
authors: Majhi
authors: Ramakrishnan Ayloor
authors: RA
authors: Seshadhri
authors: Gnana Sagar
authors: GS
authors: Tenali
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001706:Biopsy; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D054747:Histiocytic Sarcoma / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007583:Jejunum / Q000473:pathology; D008853:Microscopy; D011956:Receptors, Cell Surface / Q000032:analysis; D013270:Stomach / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface