title: In vitro antioxidant and anti-proliferation activities of polysaccharides from various extracts of different mushrooms.
abstract: Polysaccharides were extracted from eight kinds of Chinese mushrooms using three solvents and were evaluated for their total carbohydrate, polyphenolic and protein contents, and antioxidant and anti-proliferation activities. The results suggested that all the polysaccharides had significant antioxidant capacities (EC(50) ranged from 1.70 ± 0.42 to 65.98 ± 1.74 μM TE/g crude polysaccharide inhibition of ABTS(+), EC(50) ranged from 5.06 ± 0.12 to 127.38 ± 1.58 mg VCE/g CP scavenging of OH· and EC(50) ranged from 0.70 ± 0.04 to 33.54 ± 0.49 mg VCE/g CP inhibition of lipid peroxidation) (TE: trolox equivalent; VCE: VC equivalent; CP: crude polysaccharide). The acid extracts of Russula vinosa Lindblad had the highest ABTS(+) scavenging activity. Aqueous extracts of Dictyophora indusiata and Hohenbuehelia serotina possessed, respectively, the highest OH· scavenging capacity and ability to inhibit lipid peroxidation. Mushroom extracts also inhibited proliferation of HeLa and HepG2 cells in a dose-dependent manner. These results indicate that the mushroom polysaccharides might be potential antioxidant resources.
authors: Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China.
authors: Xiaoyu
authors: X
authors: Li
authors: Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China.|Northeast Forestry University, 26 Hexing Road, Xiangfang District, Harbin 150040, China.
authors: Zhenyu
authors: Z
authors: Wang
authors: Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China.
authors: Lu
authors: L
authors: Wang
authors: Institut des Régions Arides de Médenine, Laboratoire d'Aridoculture et Cultures Oasiennes, Médenine 4119, Tunisia.
authors: Elfalleh
authors: 0000-0002-3493-6451
authors: E
authors: Walid
authors: Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, China.
authors: Hua
authors: H
authors: Zhang
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011134:Polysaccharides