title: [Primary, non-metastatic gastrointestinal stromal tumour surgery: results of the GRISK study].
abstract: OBJECTIVE
  Radical surgery is the standard treatment for localised gastrointestinal stromal tumours (GIST). A series of primary GIST, their treatment and pre-established risk of recurrence after their follow-up is evaluated.
  
  
  METHODS
  A retrospective, descriptive and multicentre study was conducted on primary, non-metastatic GIST operated on between June 2007 and December 2008. The variables of greater relevance were analysed, including, location, size, mitotic index, and NHI and AFIP recurrence prognostic criteria, and their correlation with the disease-free survival (DFS) of the patients.
  
  
  RESULTS
  The series included 141 patients with a mean age of 65 years. The most frequent GIST location was in the stomach (70.8%) and small intestine (22.9%), and with a mean tumour size of 6.7 cm (0.5-35 cm). The surgery was R0 in 97.2% of cases (laparoscopic approach, 21.5%). The distribution according to NHI/Flescher criteria was, high (31.95%), and intermediate (26.4%), and according to AFIP/Miettinen criteria it was, high (22.9%) and intermediate (12.5%). After a mean follow-up of 20.3 months, there was a 7.1% (10 cases) recurrence, with only 2 cases belonging to the group with a «low risk» using the NHI and AFIP prognostic criteria. The DFS at one year was 95.5% and 91.5% at 2 years.
  
  
  CONCLUSIONS
  The series showed a high DFS and a good correlation with both the Flescher and the Miettinen criteria. However, the risk of recurrence varied according to the AFIP criteria (intermediate/high, 58.3%), or the AFIP criteria (intermediate/high, 35.4%) which included the tumour location. For this reason, we consider these latter criteria as the most adequate for assessing the prognostic risk of GIST recurrence.
authors: Unidad de Cirurgia HBP/Oncològica, Servei de Cirurgia General i Digestiva, Hospital Santa Creu i Sant Pau, UAB, Barcelona. vartigas@santpau.cat
authors: Vicente
authors: V
authors: Artigas Raventós
authors: Antonio
authors: A
authors: López Pousa
authors: Luis
authors: L
authors: Ortega Medina
authors: Alvaro
authors: A
authors: Díaz de Liaño Argüelles
authors: Juan Ángel
authors: JÁ
authors: Fernández Hernández
authors: José Luis
authors: JL
authors: Lucena de la Poza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000601:surgery*; D006801:Humans; D007414:Intestinal Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000601:surgery*; D055815:Young Adult