title: Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice.
abstract: Accumulation of amyloid-β peptides (Aβ) and cholinergic degeneration are hallmarks of Alzheimer's disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble Aβ42 levels were detected in the septum by 2 months of age, reaching their highest levels at 3-6 months and decreasing at 12 months. Deficits in the number of septal cholinergic neurons and the length of hippocampal cholinergic axons were observed starting at 4 months in 3xTg-AD mice. Our results show that septal Aβ and septohippocampal cholinergic pathology in 3xTg-AD mice occur at an early stage of disease.
authors: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Biological Sciences, Brain Sciences, Toronto, ON, Canada.
authors: M Teresa
authors: MT
authors: Girão da Cruz
authors: Jessica
authors: J
authors: Jordão
authors: Kevin A
authors: KA
authors: Dasilva
authors: Carlos A
authors: CA
authors: Ayala-Grosso
authors: Athéna
authors: A
authors: Ypsilanti
authors: Ying-Qi
authors: YQ
authors: Weng
authors: Frank M
authors: FM
authors: Laferla
authors: Joanne
authors: J
authors: McLaurin
authors: Isabelle
authors: I
authors: Aubert
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology; D059329:Cholinergic Neurons / Q000378:metabolism / Q000473:pathology*; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D020665:Septum of Brain / Q000378:metabolism* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides