title: Effects of ibutilide on canine cardiac pacing threshold and on induction rates of atrial fibrillation.
abstract: This study aims to observe the effects of ibutilide on canine cardiac pacing threshold and on induction rates of atrial fibrillation. Eighteen mongrel dogs were anesthetized and administrated with ibutilide. The pacing thresholds and induction rates of atrial fibrillation were measured with and without ibutilide (10-min infusion dose was 0.10 mg kg(-1), followed by a maintaining dose of 0.01 mg min(-1) 30 min later). This study found that ibutilide increases pacing thresholds in dogs. Moreover, there were significant differences between pacing thresholds with and without ibutilide (P < 0.05). Further, ibutilide significantly reduces the induction rates of atrial fibrillation (P < 0.05). Our findings indicate that pacing voltage changes should be closely monitored in patients taking anti-arrhythmic drugs, who are treated with cardiac stimulation or have undergone pacemaker implantation. We also found that ibutilide is an effective drug in preventing or controlling atrial fibrillation.
authors: Department of Cardiology, Aviation General Hospital, An Ding Men Wai Bei Yuan Road 3, Beijing 100012, China. sunjianling2000@yahoo.com.cn
authors: Jian-ling
authors: JL
authors: Sun
authors: Rong
authors: R
authors: Han
authors: Ji-hong
authors: JH
authors: Guo
authors: Xiao-ying
authors: XY
authors: Li
authors: Xian-lin
authors: XL
authors: Ma
authors: Chong-yu
authors: CY
authors: Wang
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D004285:Dogs; D004554:Electric Countershock; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D010138:Pacemaker, Artificial; D011667:Pulmonary Veins / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D013449:Sulfonamides; C067192:ibutilide