title: Acute phase response to Mycoplasma haemofelis and 'Candidatus Mycoplasma haemominutum' infection in FIV-infected and non-FIV-infected cats.
abstract: The pathogenicity of Haemoplasma spp. in cats varies with 'Candidatus Mycoplasma haemominutum' (CMhm) causing subclinical infection while Mycoplasma haemofelis (Mhf) often induces haemolytic anaemia. The aims of this study were to characterise the acute phase response (APR) of the cat to experimental infection with Mhf or CMhm, and to determine whether chronic feline immunodeficiency virus (FIV) infection influences this response. The acute phase proteins serum amyloid A (SAA), haptoglobin (Hp) and α-1-acid glycoprotein (AGP) concentrations were measured pre-infection and every 7-14 days up to day 100 post-infection (pi) in cats infected with either Mhf or CMhm. Half of each group of cats (6/12) were chronically and subclinically infected with FIV. Marbofloxacin treatment was given on days 16-44 pi to half of the Mhf-infected cats, and on days 49-77 pi to half of the CMhm-infected cats. FIV-infected animals had significantly lower AGP concentrations, and significantly greater Hp concentrations than non-FIV-infected cats when infected with CMhm and Mhf, respectively. Both CMhm and Mhf infection were associated with significant increases in SAA concentrations, while AGP concentrations were only significantly increased by Mhf infection. Mhf-infected cats had significantly greater SAA concentrations than CMhm-infected animals. Both Mhf and CMhm infections were associated with an APR, with Mhf infection inducing a greater response. Chronic FIV infection appeared to modify the APR, which varied with the infecting Haemoplasma species.
authors: School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UK. rm.korman@bristol.ac.uk
authors: R M
authors: RM
authors: Korman
authors: J J
authors: JJ
authors: Cerón
authors: T G
authors: TG
authors: Knowles
authors: E N
authors: EN
authors: Barker
authors: P D
authors: PD
authors: Eckersall
authors: S
authors: S
authors: Tasker
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000821:virology*; D002415:Cats; D002908:Chronic Disease; D060085:Coinfection / Q000662:veterinary; D004334:Drug Administration Schedule / Q000662:veterinary; D024841:Fluoroquinolones / Q000627:therapeutic use; D006242:Haptoglobins / Q000378:metabolism; D016089:Immunodeficiency Virus, Feline / Q000502:physiology; D016180:Lentivirus Infections / Q000662:veterinary* / Q000821:virology; D009174:Mycoplasma / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D009391:Nephelometry and Turbidimetry / Q000662:veterinary; D009961:Orosomucoid / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
chemical_list: D000209:Acute-Phase Proteins; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D006242:Haptoglobins; D009961:Orosomucoid; D000685:Serum Amyloid A Protein; C080260:marbofloxacin