title: Karyotypic findings in chronic myeloid leukemia cases undergoing treatment.
abstract: BACKGROUND
  Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells.
  
  
  METHODS
  In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.
  
  
  RESULTS
  Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.
  
  
  CONCLUSIONS
  This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.
authors: Centre for Genetic Disorders, Guru Nanak Dev University, Amritsar, Punjab, India.
authors: Anupam
authors: A
authors: Kaur
authors: Simran Preet
authors: SP
authors: Kaur
authors: Amarjit
authors: A
authors: Singh
authors: Jai Rup
authors: JR
authors: Singh