title: Patients' preferences for treatment outcomes of add-on antiepileptic drugs: a conjoint analysis.
abstract: To understand the relative importance of the outcomes of add-on antiepileptic drugs (AEDs) and the willingness of patients with epilepsy to accept therapeutic trade-offs between seizure control and tolerability, we administered a Web-enabled, choice-format conjoint survey to patients with a self-reported physician diagnosis of epilepsy and symptoms of partial seizures. Patients answered nine choice questions to evaluate treatment outcomes of two different hypothetical add-on AEDs. Patients were first asked to choose the better of the two medicines and then asked a follow-up question about whether or not they would add the selected AED to their current treatment regimen. Our study demonstrated that patients with epilepsy consider seizure reduction to be the top priority when ranking it against the reduction or elimination of side effects. This study aids in better understanding of patients' AED treatment preferences and may aid in management of epilepsy.
authors: GlaxoSmithKline, Research Triangle Park, NC 27709, USA. ranjani.y.manjunath@gsk.com
authors: Ranjani
authors: R
authors: Manjunath
authors: Jui-Chen
authors: JC
authors: Yang
authors: Alan B
authors: AB
authors: Ettinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009862:Online Systems; D057240:Patient Preference / Q000523:psychology*; D057566:Self Report; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants