title: The relationship between glucose metabolism disorders and malignant thyroid disease.
abstract: BACKGROUND
  Previous studies have shown a positive relationship between insulin resistance and several common adult cancers. The present retrospective study aimed to investigate the association between glucose metabolism disorders (GMDs) and the prevalence of thyroid cancer.
  
  
  METHODS
  We investigated the data of 4272 patients who had undergone fine-needle aspiration biopsy (FNAB) of thyroid nodules. The biopsy results were evaluated as diagnostic or non-diagnostic and the diagnostic results were classified as benign, malignant, and indeterminate. In this study, we included 2234 of the above patients who had undergone FNAB at our hospital and whose biopsy results were evaluated as diagnostic and were classified as either benign or malignant. We obtained the cytologic data and the glucose metabolism status of these patients retrospectively.
  
  
  RESULTS
  Of the 2234 patients, 629 (28.1 %) had GMD (impaired fasting glucose, impaired glucose tolerance). Malignant cytology was determined in 106 (4.7 %) patients overall. Of the 629 patients with GMD, 582 (92.5 %) patients had benign cytology and 47 (7.5 %) patients had malignant cytology. Fifty-nine (3.7 %) of the 1605 normoglycemic patients had malignant cytology. Malignant cytology was determined more frequently ın the patients who had GMDs (p < 0.001).
  
  
  CONCLUSIONS
  The results demonstrated that thyroid cancer prevalence was higher in patients with GMD. According to our results, GMD should be considered as a risk factor for malignancy in the evaluation of thyroid nodules.
authors: Department of Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey. mduran2@gmail.com
authors: Ayse Ocak
authors: AO
authors: Duran
authors: Cüneyd
authors: C
authors: Anil
authors: Alptekin
authors: A
authors: Gursoy
authors: Aslı
authors: A
authors: Nar
authors: Ozden
authors: O
authors: Altundag
authors: Neslihan Bascil
authors: NB
authors: Tutuncu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D005260:Female; D044882:Glucose Metabolism Disorders / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*; D016606:Thyroid Nodule / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D013972:Thyrotropin