title: Post-transfusion hypertension, convulsion and intracranial haemorrhage in β-thalassemia major.
abstract: The haematologic disorder β-thalassemia major is common in Pakistan. We describe a patient with undiagnosed thalassemia presenting with hypertension and convulsions and found to have cerebral haemorrhage on neuro-imaging. He had been transfused 2 weeks before this illness. Our experience is similar to a few case reports described in literature that were found to have cerebral haemorrhages post-mortem after a similar clinical presentation. All patients had a blood transfusion within 2 weeks prior to the presentation so association with transfusion has been proposed. We have reviewed the several mechanisms presented and discussed the findings.
authors: Department of Paediatrics, Hiawatha Paediatrics, Iowa Health Physicians and Clinics, IA, USA. masoodsa@ihs.org
authors: Syed Asif
authors: SA
authors: Masood
authors: Anita
authors: A
authors: Zaidi
mesh_terms: D001926:Brain Death / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D017809:Fatal Outcome; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male; D012640:Seizures / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D065227:Transfusion Reaction; D014474:Unconsciousness / Q000150:complications; D017086:beta-Thalassemia / Q000150:complications / Q000628:therapy*