title: Epstein-Barr virus-positive mucocutaneous ulcer of the oral cavity: the importance of having a detailed clinical history to reach a correct diagnosis.
abstract: Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a recently recognized clinicopathological entity. It presents as an ulcerative lesion with lymphoma-like histologic features and is clinically associated with various types of immunosuppression. EBVMCU lesions respond well to conservative measures aimed at correcting the underlying immunosuppression. The case described clearly demonstrates the importance of appropriately completing biopsy submission forms with a detailed clinical history, thus aiding the histopathologist in reaching the correct diagnosis, particularly in pathologic conditions that have similar or overlapping histopathological features. Failure to do so may lead to incorrect diagnosis and management.
authors: Specialty Registrar in Oral and Maxillofacial Surgery, Worcestershire Royal Hospital, Worcester, UK. attardalan@yahoo.com
authors: Alan A
authors: AA
authors: Attard
authors: Prav
authors: P
authors: Praveen
authors: Paul J S
authors: PJ
authors: Dunn
authors: Graham J
authors: GJ
authors: James
mesh_terms: D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000473:pathology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008487:Medical History Taking; D008727:Methotrexate / Q000009:adverse effects*; D019226:Oral Ulcer / Q000276:immunology / Q000473:pathology* / Q000821:virology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004279:DNA, Viral; D007166:Immunosuppressive Agents; D008727:Methotrexate