title: A click strategy for the immobilization of MacMillan organocatalysts onto polymers and magnetic nanoparticles.
abstract: A chemically modified, first generation MacMillan imidazolidin-4-one has been anchored onto 1% DVB Merrifield resin and Fe3O4 (5.3 ± 1.4 nm) magnetic nanoparticles through copper-catalyzed alkyne azide cycloaddition (CuAAC) reactions. The resulting immobilized catalysts have been successfully used in the asymmetric Friedel-Crafts alkylation of N-substituted pyrroles with α,β-unsaturated aldehydes. The PS-supported catalyst (B) showed higher catalytic activity and enantioselectivity, while the MNP-supported one (A) showed higher recyclability and could be used in a sequential process with intermediate magnetic decantation.
authors: Institute of Chemical Research of Catalonia , Av. Països Catalans, 16, 43007 Tarragona, Spain, and Departament de Química Orgànica, Universitat de Barcelona , c/Martí I Franqués 1-11, 08080 Barcelona, Spain.
authors: Paola
authors: P
authors: Riente
authors: Jagjit
authors: J
authors: Yadav
authors: Miquel A
authors: MA
authors: Pericàs