title: Synthesis and characterization of luminescent cadmium selenide/zinc selenide/zinc sulfide cholinomimetic quantum dots.
abstract: Luminescent quantum dots conjugated with highly selective molecular recognition ligands are widely used for targeting and imaging biological structures. In this paper, water soluble cholinomimetic cadmium selenide (core), zinc selenide/zinc sulfide (shell) quantum dots were synthesized for targeting cholinergic sites. Cholinomimetic specificity was incorporated by conjugation of the quantum dots to an aminated analogue of hemicholinium-15, a well known competitive inhibitor of the high affinity choline uptake transporter. Detailed evaluation of the nanocrystal synthesis and characterization of the final product was conducted by (1)H and (31)P NMR, absorption and emission spectroscopy, as well as transmission electron microscopy.
authors: Department of Chemistry, College of Natural Sciences and Mathematics, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA.
authors: Claire
authors: C
authors: Gégout
authors: Maria L
authors: ML
authors: McAtee
authors: Nichole M
authors: NM
authors: Bennett
authors: L M
authors: LM
authors: Viranga Tillekeratne
authors: Jon R
authors: JR
authors: Kirchhoff
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D019187:Cadmium Compounds / Q000737:chemistry*; D018678:Cholinergic Agents / Q000737:chemistry* / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D051379:Mice; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D013574:Synaptosomes / Q000378:metabolism; D014867:Water / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D018678:Cholinergic Agents; D026901:Membrane Transport Proteins; D018036:Selenium Compounds; D013440:Sulfides; D017967:Zinc Compounds; C065637:choline transporter; D014867:Water; C058667:cadmium selenide; C031238:zinc sulfide; C044696:zinc selenide