title: Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens' antibacterial susceptibility.
abstract: For the purpose of nationwide surveillance of antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, the Japanese Society of Chemotherapy (JSC) started a survey in 2006. From 2009, JSC continued the survey in collaboration with the Japanese Association for Infectious Diseases and the Japanese Society for Clinical Microbiology. The fourth-year survey was conducted during the period from January and April 2009 by the three societies. A total of 684 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 635 strains (130 Staphylococcus aureus, 127 Streptococcus pneumoniae, 4 Streptococcus pyogenes, 123 Haemophilus influenzae, 70 Moraxella catarrhalis, 78 Klebsiella pneumoniae, and 103 Pseudomonas aeruginosa). A maximum of 45 antibacterial agents including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), four aminoglycosides, four macrolides (including ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). Incidence of methicillin-resistant S. aureus (MRSA) was as high as 58.5 %, and that of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) was 6.3 % and 0.0 %, respectively. Among H. influenzae, 21.1 % of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 18.7 % to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.7 % to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5 %) of β-lactamase-producing strains has been suspected in Moraxella catarrhalis isolates. Four (3.2 %) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5 %) of P. aeruginosa were found to be metallo-β-lactamase-producing strains, including three (1.9 %) suspected multi-drug resistant strains showing resistance against imipenem, amikacin, and ciprofloxacin. Continuous national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.
authors: The Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases and Japanese Society for Clinical Microbiology, c/o Japanese Society of Chemotherapy, Nichinai Kaikan B1, 3-28-8 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors: Akira
authors: A
authors: Watanabe
authors: Katsunori
authors: K
authors: Yanagihara
authors: Tetsuya
authors: T
authors: Matsumoto
authors: Shigeru
authors: S
authors: Kohno
authors: Nobuki
authors: N
authors: Aoki
authors: Toyoko
authors: T
authors: Oguri
authors: Junko
authors: J
authors: Sato
authors: Tetsuro
authors: T
authors: Muratani
authors: Morimasa
authors: M
authors: Yagisawa
authors: Kazuhiko
authors: K
authors: Ogasawara
authors: Naoto
authors: N
authors: Koashi
authors: Tsuneo
authors: T
authors: Kozuki
authors: Akira
authors: A
authors: Komoto
authors: Yoshisaburo
authors: Y
authors: Takahashi
authors: Toshikatsu
authors: T
authors: Tsuji
authors: Michinori
authors: M
authors: Terada
authors: Kunio
authors: K
authors: Nakanishi
authors: Rikizo
authors: R
authors: Hattori
authors: Yukio
authors: Y
authors: Hirako
authors: Akinori
authors: A
authors: Maruo
authors: Shinichi
authors: S
authors: Minamitani
authors: Kohei
authors: K
authors: Morita
authors: Tomotaro
authors: T
authors: Wakamura
authors: Keisuke
authors: K
authors: Sunakawa
authors: Hideaki
authors: H
authors: Hanaki
authors: Yoshinobu
authors: Y
authors: Ohsaki
authors: Yasuhito
authors: Y
authors: Honda
authors: Shoichi
authors: S
authors: Sasaoka
authors: Hiroaki
authors: H
authors: Takeda
authors: Hideki
authors: H
authors: Ikeda
authors: Atsuko
authors: A
authors: Sugai
authors: Makoto
authors: M
authors: Miki
authors: Susumu
authors: S
authors: Nakanowatari
authors: Hiroshi
authors: H
authors: Takahashi
authors: Mutsuko
authors: M
authors: Utagawa
authors: Nobuyuki
authors: N
authors: Kobayashi
authors: Jin
authors: J
authors: Takasaki
authors: Hisami
authors: H
authors: Konosaki
authors: Yasuko
authors: Y
authors: Aoki
authors: Michi
authors: M
authors: Shoji
authors: Hajime
authors: H
authors: Goto
authors: Takeshi
authors: T
authors: Saraya
authors: Daisuke
authors: D
authors: Kurai
authors: Mitsuhiro
authors: M
authors: Okazaki
authors: Yoshio
authors: Y
authors: Kobayashi
authors: Yasuhiro
authors: Y
authors: Katono
authors: Akihiko
authors: A
authors: Kawana
authors: Katsu
authors: K
authors: Saionji
authors: Naoki
authors: N
authors: Miyazawa
authors: Yoshimi
authors: Y
authors: Sato
authors: Yuji
authors: Y
authors: Watanuki
authors: Makoto
authors: M
authors: Kudo
authors: Shigeru
authors: S
authors: Ehara
authors: Hiroki
authors: H
authors: Tsukada
authors: Yumiko
authors: Y
authors: Imai
authors: Nobuei
authors: N
authors: Watabe
authors: Sakura
authors: S
authors: Aso
authors: Yasuo
authors: Y
authors: Honma
authors: Hiroshige
authors: H
authors: Mikamo
authors: Yuka
authors: Y
authors: Yamagishi
authors: Yoshio
authors: Y
authors: Takesue
authors: Yasunao
authors: Y
authors: Wada
authors: Tadahiro
authors: T
authors: Nakamura
authors: Noriko
authors: N
authors: Mitsuno
authors: Keiichi
authors: K
authors: Mikasa
authors: Kei
authors: K
authors: Kasahara
authors: Kenji
authors: K
authors: Uno
authors: Reiko
authors: R
authors: Sano
authors: Naoyuki
authors: N
authors: Miyashita
authors: Yukinori
authors: Y
authors: Kurokawa
authors: Mariko
authors: M
authors: Takaya
authors: Masao
authors: M
authors: Kuwabara
authors: Yaeko
authors: Y
authors: Watanabe
authors: Masao
authors: M
authors: Doi
authors: Satomi
authors: S
authors: Shimizu
authors: Kiyoshi
authors: K
authors: Negayama
authors: Junichi
authors: J
authors: Kadota
authors: Kazufumi
authors: K
authors: Hiramatsu
authors: Yoshitomo
authors: Y
authors: Morinaga
authors: Junichi
authors: J
authors: Honda
authors: Masaki
authors: M
authors: Fujita
authors: Satoshi
authors: S
authors: Iwata
authors: Aikichi
authors: A
authors: Iwamoto
authors: Takayuki
authors: T
authors: Ezaki
authors: Shoichi
authors: S
authors: Onodera
authors: Shinya
authors: S
authors: Kusachi
authors: Kazuhiro
authors: K
authors: Tateda
authors: Michio
authors: M
authors: Tanaka
authors: Kyoichi
authors: K
authors: Totsuka
authors: Yoshihito
authors: Y
authors: Niki
authors: Tetsuro
authors: T
authors: Matsumoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D016009:Chi-Square Distribution; D024881:Drug Resistance, Bacterial; D006801:Humans; D007564:Japan / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D062486:Public Health Surveillance; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology*; D012958:Societies, Scientific
chemical_list: D000900:Anti-Bacterial Agents