title: Potential impact of curcumin and taurine on human hepatoma cells using Huh-7 cell line.
abstract: OBJECTIVE
  This study aimed at exploring the role of curcumin and taurine alone or in combination against cultured human hepatoma cells (Huh-7 cells).
  
  
  METHODS
  Huh-7 cells were plated and treated with various concentrations of curcumin and/or taurine. Hemocytometer cell count, cell viability, quantification of γ-IFN concentrations, and flow cytometric analyses for CD4, CD8, and CD25 were carried out.
  
  
  RESULTS
  There were significant increases in the levels of cell density, γ-IFN, and CD8, accompanied with significant decrease in the level of CD4, when comparing cultured cells treated with curcumin and taurine with control cultured cells.
  
  
  CONCLUSIONS
  Curcumin/taurine in combination formula is better treatment than single therapy, with respect to cell density and γ-IFN. Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with consequent induction of CD8 T-cell responses to lyse tumor cells.
authors: Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt. ahmedchemia87@yahoo.com
authors: Ahmed A
authors: AA
authors: Abd-Rabou
authors: Khairy M A
authors: KM
authors: Zoheir
authors: Hanaa H
authors: HH
authors: Ahmed
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015704:CD4 Antigens / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008113:Liver Neoplasms; D013654:Taurine / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D015704:CD4 Antigens; D016827:CD8 Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D013654:Taurine; D007371:Interferon-gamma; D003474:Curcumin