title: Older adults with intellectual disability.
abstract: OBJECTIVE
  Improvements in health and social care for people with intellectual disability have led to a dramatic increase in the life expectancy of this population, resulting in a large and growing number of older adults with intellectual disability. They are at risk of age-related mental disorders such as dementia and continue to present with high rates of mental illness.
  
  
  RESULTS
  Recent research with older adults with intellectual disability has included physical health issues that may affect mental well being, and biological and clinical features of dementia in people with Down syndrome. Two key clinical trials of memantine and antioxidants for dementia in Down syndrome showed that these treatment options were ineffective in the short term. Other research focussed on environmental and psychosocial issues (including carer issues) and end-of-life care.
  
  
  CONCLUSIONS
  Improved mental well being requires effective management of mental illness and co-morbid physical health problems as well as consideration of environmental and social issues. Biological research has identified potential treatments for age-related decline, which has led to the development of medication trials. Despite disappointing results, two recent medication trials showed that randomized controlled trials are feasible in older people with intellectual disabilities - a group who are often excluded from trials.
authors: Mental Health Sciences Unit, University College London, London, UK.
authors: Amanda
authors: A
authors: Sinai
authors: Ingrid
authors: I
authors: Bohnen
authors: Andre
authors: A
authors: Strydom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D017028:Caregivers / Q000523:psychology; D003071:Cognition / Q000502:physiology; D017281:Cost of Illness; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology*; D001523:Mental Disorders / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D012944:Social Support