title: Macroscopic volume change of dynamic hydrogels induced by reversible DNA hybridization.
abstract: Molecular recognition is fundamental to the specific interactions between molecules, of which the best known examples are antibody-antigen binding and cDNA hybridization. Reversible manipulation of the molecular recognition events is still a very challenging topic, and such studies are often performed at the molecular level. An important consideration is the collection of changes at the molecular level to provide macroscopic observables. This research makes use of photoresponsive molecular recognition for the fabrication of novel photoregulated dynamic materials. Specifically, a dynamic hydrogel was prepared by grafting azobenzene-tethered ssDNA and its cDNA to the hydrogel network. The macroscopic volume of the hydrogel can be manipulated through the photoreversible DNA hybridization controlled by alternate irradiation of UV and visible light. The effects of synthetic parameters including the concentration of DNA, polymer monomer, and permanent cross-linker are also discussed.
authors: Department of Chemistry, Center for Research at Bio/nano Interface, Shands Cancer Center, University of Florida, Gainesville, Florida 32611-7200, USA.
authors: Lu
authors: L
authors: Peng
authors: Mingxu
authors: M
authors: You
authors: Quan
authors: Q
authors: Yuan
authors: Cuichen
authors: C
authors: Wu
authors: Da
authors: D
authors: Han
authors: Yan
authors: Y
authors: Chen
authors: Zhihua
authors: Z
authors: Zhong
authors: Jiangeng
authors: J
authors: Xue
authors: Weihong
authors: W
authors: Tan
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D018076:DNA, Complementary / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008027:Light; D009693:Nucleic Acid Hybridization; D055668:Photochemical Processes; D014466:Ultraviolet Rays
chemical_list: D001391:Azo Compounds; D018076:DNA, Complementary; D004277:DNA, Single-Stranded; D020100:Hydrogels; C009850:azobenzene