title: Ubiquitin removal in the TGF-β pathway.
abstract: The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.
authors: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. massaguj@mskcc.org
authors: Kamna
authors: K
authors: Aggarwal
authors: Joan
authors: J
authors: Massagué
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology*; D002462:Cell Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D015513:Oncogene Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*; D064570:Ubiquitin-Specific Proteases
chemical_list: D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D018125:Receptors, Transforming Growth Factor beta; C486203:USP4 protein, human; C082325:Usp4 protein, mouse; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D000077293:Receptor, Transforming Growth Factor-beta Type I; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases