title: Protective effects of Moutan Cortex Radicis against acute hepatotoxicity.
abstract: This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl(4))-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl(4) (10 µL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl(4), GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl(4) or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in inflammatory cell infiltration. These changes were inhibited by MCR. Serum total bilirubin concentration increased and bile flow decreased significantly 48 h after ANIT treatment, which was attenuated by MCR. Our results suggest that MCR has a protective effect on acute liver injury.
authors: School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors: Juhyun
authors: J
authors: Park
authors: Hyo-Yeon
authors: HY
authors: Kim
authors: Sun-Mee
authors: SM
authors: Lee
mesh_terms: D015058:1-Naphthylisothiocyanate / Q000633:toxicity; D000284:Administration, Oral; D000818:Animals; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008297:Male; D051379:Mice; D029596:Paeonia; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000637:Transaminases / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C038881:moutan cortex; D015058:1-Naphthylisothiocyanate; D002251:Carbon Tetrachloride; D000637:Transaminases; D001663:Bilirubin