title: Cross-validation of a Sequential Organ Failure Assessment score-based model to predict mortality in patients with cancer admitted to the intensive care unit.
abstract: OBJECTIVE
  This study aims to validate the performance of the Sequential Organ Failure Assessment (SOFA) score to predict death of critically ill patients with cancer.
  
  
  METHODS
  We conducted a retrospective observational study including adults admitted to the intensive care unit (ICU) between January 1, 2006, and December 31, 2008. We randomly selected training and validation samples in medical and surgical admissions to predict ICU and in-hospital mortality. By using logistic regression, we calculated the probabilities of death in the training samples and applied them to the validation samples to test the goodness-of-fit of the models, construct receiver operator characteristics curves, and calculate the areas under the curve (AUCs).
  
  
  RESULTS
  In predicting mortality at discharge from the unit, the AUC from the validation group of medical admissions was 0.7851 (95% confidence interval [CI], 0.7437-0.8264), and the AUC from the surgical admissions was 0.7847 (95% CI, 0.6319-0.937). The AUCs of the SOFA score to predict mortality in the hospital after ICU admission were 0.7789 (95% CI, 0.74-0.8177) and 0.7572 (95% CI, 0.6719-0.8424) for the medical and surgical validations groups, respectively.
  
  
  CONCLUSIONS
  The SOFA score had good discrimination to predict ICU and hospital mortality. However, the observed underestimation of ICU deaths and unsatisfactory goodness-of-fit test of the model in surgical patients to indicate calibration of the score to predict ICU mortality is advised in this group.
authors: Department of Critical Care Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.
authors: Marylou
authors: M
authors: Cárdenas-Turanzas
authors: Joe
authors: J
authors: Ensor
authors: Chris
authors: C
authors: Wakefield
authors: Karen
authors: K
authors: Zhang
authors: Susannah Kish
authors: SK
authors: Wallace
authors: Kristen J
authors: KJ
authors: Price
authors: Joseph L
authors: JL
authors: Nates
mesh_terms: D000328:Adult; D000368:Aged; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality*; D009369:Neoplasms / Q000453:epidemiology*; D063305:Organ Dysfunction Scores; D012189:Retrospective Studies; D012720:Severity of Illness Index