title: Cell death biomarkers as early predictors for hepatic dysfunction in patients after orthotopic liver transplantation.
abstract: BACKGROUND
  Valid prognostic factors for early identification of a complicated course after orthotopic liver transplantation from deceased donors are rare. The aim of this study was to investigate the prognostic value of different cell death biomarkers and inflammatory markers in patients after orthotopic liver transplantation from deceased donors.
  
  
  METHODS
  In total, 100 patients were evaluated for short-term complications within 10 days after orthotopic liver transplantation from deceased donors. Blood samples were collected before surgery, immediately after the end of the surgical procedure, and 1 day and 3, 5, and 7 days later. Plasma levels of total keratin 18, keratin 18 fragments, interleukin 6, tumor necrosis factor α, and soluble intercellular adhesion molecule 1 were measured.
  
  
  RESULTS
  Total keratin 18 was demonstrated to be favorable in its prognostic value for early identification of a complicated course in comparison to routine markers of liver impairment (e.g., aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase). In contrast, inflammation markers (e.g., interleukin 6, tumor necrosis factor α and soluble intercellular adhesion molecule 1) were unsuitable for predicting early complications after liver transplantation from deceased donors.
  
  
  CONCLUSIONS
  For early identification of patients at high risk for complications, the implementation of total keratin 18 measurements in routine diagnostics after orthotopic liver transplantation from deceased donors should be taken into consideration.
authors: Department of Anaesthesiology, University of Heidelberg, Heidelberg, Germany. thorsten.brenner@med.uni-heidelberg.de
authors: Thorsten
authors: T
authors: Brenner
authors: Claudia
authors: C
authors: Rosenhagen
authors: Holger
authors: H
authors: Brandt
authors: Felix C F
authors: FC
authors: Schmitt
authors: Gregor E
authors: GE
authors: Jung
authors: Peter
authors: P
authors: Schemmer
authors: Jan
authors: J
authors: Schmidt
authors: Markus
authors: M
authors: Mieth
authors: Thomas
authors: T
authors: Bruckner
authors: Christoph
authors: C
authors: Lichtenstern
authors: Eike O
authors: EO
authors: Martin
authors: Markus A
authors: MA
authors: Weigand
authors: Stefan
authors: S
authors: Hofer
mesh_terms: D015415:Biomarkers / Q000097:blood; D016923:Cell Death; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D053538:Keratin-18 / Q000097:blood*; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; C488421:KRT18 protein, human; D053538:Keratin-18; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1