title: Thromboembolic tendency (TE) in IBD (Inflammatory bowel disease) patients.
abstract: BACKGROUND
  The incidence of TE events in IBD patients is higher then in population control. The main reason of it, is the hypercoaugulable state. Our aim was to detect serum markers related to TE, that can assume preventing and prognostic meanings.
  
  
  METHODS
  We performed a 3 years study on 71 patients with IBD, evaluating hypercoaugulability, and then we compared the results with a 71 patients non IBD group control. We also investigated patients of both groups concerning TE events occurred already.
  
  
  RESULTS
  In IBD group we found out that 16 patients (22.5%) had history of TE versus >1% of group control. Nineteen of them, already had knowledge of their previous hypercoaugulating condition. 48 (67%) had increased markers value versus less then 6% detected in group control. In IBD group 43% ,20% and 4.2% had respectively 1, 1-3 or > 3 markers higher levels then normal range. Among the markers investigated, we detected increased levels of plated in 33%, homocysteine in 26.7%, d-dimero 25.3%, c3 in 15.4%, apcr in 5.6%.
  
  
  CONCLUSIONS
  From our study we detected highest incidence of TE events, and hypercoaugulating status in IBD group. In our previous investigations, plated, homocysteine, d-dimero, c3, and apcr, seems to be the TE markers with higher sensibility. It seems reasonable, according our experience, to propose a new TE risk score index for IBD patients: low, mild and high risk respectively for patients with 1, 1-3 and >3 markers with higher serum levels then normal range.
  
  
  BACKGROUND
  Inflammatory bowel disease, Thromboembolism risk score.
authors: Department of Gerontology, Second University of Naples, Italy.
authors: Antonio
authors: A
authors: Canero
authors: Domenico
authors: D
authors: Parmeggiani
authors: Nicola
authors: N
authors: Avenia
authors: Pietro Francesco
authors: PF
authors: Atelli
authors: Luigi
authors: L
authors: Goffredi
authors: Roberto
authors: R
authors: Peltrini
authors: Imma
authors: I
authors: Madonna
authors: Pasquale
authors: P
authors: Ambrosino
authors: Sarah
authors: S
authors: Apperti
authors: Marco
authors: M
authors: Apperti
mesh_terms: D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D011237:Predictive Value of Tests; D012307:Risk Factors; D013923:Thromboembolism / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*