title: Seroprevalence of human papillomavirus (HPV) type 6 and 16 vary by anatomic site of HPV infection in men.
abstract: BACKGROUND
  It is largely unknown if antihuman papillomavirus (HPV) serum antibody responses vary by anatomic site of infection in men.
  
  
  METHODS
  This study assessed type-specific anti-HPV serum antibody prevalence associated with corresponding HPV DNA detection in the external genitalia and the anal canal of 1,587 heterosexual men and 199 men who have sex with men (MSM).
  
  
  RESULTS
  We observed that HPV 6 and 16 seroprevalence was higher in the presence of same HPV-type infection in the anal canal compared with same HPV-type infection in the external genitalia only, and among MSM compared with the heterosexual men. Seropositivity to HPV 6 was strongly associated with HPV 6 DNA detection in the anal canal but not in the external genitalia alone among both heterosexual men [adjusted prevalence ratio (APR), anal+/genital+ vs. anal-/genital-: 4.2, 95% confidence interval (CI), 11.7-10.5; anal+/genital- vs. anal-/genital-: 7.9 (95% CI, 3.7-17.0)] and MSM [APR, anal+/genital+ vs. anal-/genital-: 5.6 (95% CI, 2.7-11.9); anal+/genital- vs. anal-/genital-: 3.2 (95% CI, 2.1-4.9)]. Similar associations between seropositivity to HPV 16 and anal HPV 16 DNA detection were only observed in MSM [anal+/genital+ vs. anal-/genital-: 3.1 (95% CI, 2.0-5.0); anal+/genital- vs. anal-/genital-: 2.2 (95% CI, 1.3-3.5)].
  
  
  CONCLUSIONS
  Our data showed that seroprevalence varied by anatomic site of HPV infection, suggesting differences in epithelium type present at these anatomic sites may be relevant.
  
  
  CONCLUSIONS
  Our finding is instrumental in advancing our understanding of immune mechanism involved in anatomic site-specific antibody response.
authors: H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9416, USA.
authors: Beibei
authors: B
authors: Lu
authors: Raphael P
authors: RP
authors: Viscidi
authors: Yougui
authors: Y
authors: Wu
authors: Alan G
authors: AG
authors: Nyitray
authors: Luisa L
authors: LL
authors: Villa
authors: Eduardo
authors: E
authors: Lazcano-Ponce
authors: Roberto J
authors: RJ
authors: Carvalho da Silva
authors: Maria Luiza
authors: ML
authors: Baggio
authors: Manuel
authors: M
authors: Quiterio
authors: Jorge
authors: J
authors: Salmerón
authors: Danelle C
authors: DC
authors: Smith
authors: Martha
authors: M
authors: Abrahamsen
authors: Mary
authors: M
authors: Papenfuss
authors: Anna R
authors: AR
authors: Giuliano
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D004279:DNA, Viral / Q000032:analysis; D052162:Human papillomavirus 16 / Q000276:immunology*; D052163:Human papillomavirus 6 / Q000276:immunology*; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral