title: Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells.
abstract: Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 h after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation.
authors: Department of Environmental Health Science, Nara Women's University, Nara 630-8506, Japan.
authors: Naoko
authors: N
authors: Okumura
authors: Hitomi
authors: H
authors: Yoshida
authors: Yuri
authors: Y
authors: Nishimura
authors: Yasuko
authors: Y
authors: Kitagishi
authors: Satoru
authors: S
authors: Matsuda