title: [Th9 cells. Functionally important or just an epiphenomenon?].
abstract: Development of the recently described Th9 cells is selectively and dynamically controlled by epigenetic modifications. The selective epigenetic inactivation of the PU.1 promoter associated with diminished Th9 cell differentiation by naive CD4 T cells allows the assumption of a special physiologic role of IL-9. Once deregulated, IL-9 seems to play an important role in the pathogenesis of several autoimmune disorders.
authors: Rheumaeinheit, Medizinische Klinik IV, Klinikum der Universität München, Campus Innenstadt, Pettenkoferstr. 8a, 80336, München, Deutschland. andreas.ramming@med.uni-muenchen.de
authors: A
authors: A
authors: Ramming
authors: H
authors: H
authors: Schulze-Koops
authors: A
authors: A
authors: Skapenko
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D044127:Epigenesis, Genetic / Q000276:immunology*; D006801:Humans; D016906:Interleukin-9 / Q000276:immunology*; D018448:Models, Immunological; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D016207:Cytokines; D016906:Interleukin-9