title: Successful treatment with tocilizumab in a case of Cogan's syndrome complicated with aortitis.
abstract: A 69-year-old man with sensorineural hearing loss and iritis was diagnosed with atypical Cogan's syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis and seronegative arthritis. Remission induced by treatment with high doses of prednisolone was followed by relapse within 1 year. Although his condition was resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine and adalimumab, his symptoms, inflammatory response and quality of life measures were successfully improved by tocilizumab, a humanized anti-interleukin-6 receptor antibody.
authors: Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. shimu-tky@umin.ac.jp
authors: Mihoko
authors: M
authors: Shibuya
authors: Keishi
authors: K
authors: Fujio
authors: Kaoru
authors: K
authors: Morita
authors: Hiroaki
authors: H
authors: Harada
authors: Hiroko
authors: H
authors: Kanda
authors: Kazuhiko
authors: K
authors: Yamamoto
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001025:Aortitis / Q000150:complications / Q000188:drug therapy*; D055952:Cogan Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007166:Immunosuppressive Agents; C502936:tocilizumab