title: Influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.
abstract: OBJECTIVE
  to evaluate the influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.
  
  
  METHODS
  this was a cross sectional study on 40 HIV patients (16 with HIV-TB coinfection, and 24 HIV without TB) conducted in HIV-AIDS study group (Pokdisus AIDS) of Cipto Mangunkusumo Hospital, Jakarta in October-November 2008. Those who had consumed both drugs for at least 2 weeks were recruited. Plasma nevirapine level was measured by using HPLC method, and the comparison between the two groups was done by unpaired t-test.
  
  
  RESULTS
  Nevirapine plasma level (mean±SD) in HIV patient was 7.5±2.2 ug/ml, while in HIV-TB patients it was 5.5±2.7 ug/ml (p=0.018). In most of patients receiving rifampicin, the plasma nevirapine concentration was still in therapeutic range.
  
  
  CONCLUSIONS
  co-administration of rifampicin was associated with a significant decrease in nevirapin plasma concentration. However, this level was still in therapeutic range.
authors: Department of Pharmacology, Faculty of Medicine, University of Indonesia. Jl. Salemba Raya 6, Jakarta, Indonesia. nafrialdi@yahoo.com
authors: Nafrialdi
authors: Agus W
authors: AW
authors: Nugroho
authors: Evy
authors: E
authors: Yunihastuti
authors: Meta S S
authors: MS
authors: Wiria
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood* / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000494:pharmacology* / Q000627:therapeutic use; D060085:Coinfection / Q000188:drug therapy; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000097:blood* / Q000627:therapeutic use; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D000904:Antibiotics, Antitubercular; D019829:Nevirapine; D012293:Rifampin