title: Tramadol poisoning with hyperamylasemia.
abstract: The usual reason for measuring serum amylase level is to confirm or exclude the diagnosis of pancreatitis. However, increases in serum amylase levels can occur in conditions other than pancreatitis and many of those conditions present with acute abdominal pain. In the case presented here, an unconscious patient developed a very high serum total amylase level, which was most likely due to hypoxemia and lactic acidosis secondary to an overdose of Tramadol (Nobligan) tablets. The patient was treated in the intensive care unit and had an uneventful recovery. Many diseases can cause acute elevation of serum amylase level. In lactic acidosis, the hyperamylasemia typically results from the presence of excessive salivary-type isoamylase. Therefore, isoamylase enzyme analysis is of great clinical value in the differential diagnosis of hyperamylasemia, especially in cases with concurrent lactic acidosis.
authors: Herlev Hospital, Herlev, Denmark.
authors: Alaa
authors: A
authors: El-Hussuna
authors: Regnar Bøge
authors: RB
authors: Arnesen
authors: Jacob
authors: J
authors: Rosenberg
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D001784:Blood Gas Analysis; D003128:Coma / Q000175:diagnosis / Q000209:etiology; D016638:Critical Illness / Q000628:therapy; D003937:Diagnosis, Differential; D062787:Drug Overdose / Q000175:diagnosis* / Q000188:drug therapy; D004636:Emergency Service, Hospital; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D034321:Hyperamylasemia / Q000097:blood / Q000175:diagnosis*; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis*; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D014147:Tramadol / Q000506:poisoning*; D055815:Young Adult
chemical_list: D000931:Antidotes; D014147:Tramadol