title: [Kidney and bone update : the 5-year history and future of CKD-MBD. Bisphosphonates treatment for chronic kidney disease-mineral and bone disorder].
abstract: Recently, much of the attention given to bone-mineral disorder as the prognostic factor for mortality has focused on their links to chronic-kidney disease. High-frequency severe atherosclerosis/calcinosis is observed in chronic dialysis, which leads to cardiovascular events. Recent progress in basic research has revealed certain similarities between processes of bone calcification and calcifications of vascular tissues which contribute to several cardiovascular diseases. However, the effective treatment for suppressing the progression of vascular calcification has not been established. Here we review the mechanism of vascular calcification and present our findings that a bisphosphonate is useful in prevention of vascular calcification in chronic renal failure.
authors: First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
authors: Hiroko
authors: H
authors: Mori
authors: Yosuke
authors: Y
authors: Okada
authors: Yoshiya
authors: Y
authors: Tanaka
authors: Osamu
authors: O
authors: Hashimoto
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000378:metabolism; D002908:Chronic Disease; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D008903:Minerals / Q000378:metabolism*; D061205:Vascular Calcification / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D008903:Minerals; D012968:Etidronic Acid