title: Pharmacological evaluation of LiuWei Zhuanggu Granules in rats.
abstract: Many commonly consumed foods, herbs and spices contain a complex array of naturally occurring bioactive molecules called phytochemicals, which may confer health benefits. In this study, the impact of LiuWei Zhuanggu Granules (LWZGG) on mineral metabolism in osteopenia development was evaluated. Results showed that serum estrogen, bone gla protein (BGP), and calcitonin (CT) levels, bone Ca, Zn and Cu levels, femur, lumbar vertebrae and trabecular bone density, tibia maximum stress and maximum bending strength were increased, and serum parathyroid hormone (PTH), serum and urine Ca, Zn and Cu levels were decreased in rat bone. It can be concluded that LWZGG is useful to improve bone quality in ovariectomized (OVX) rats.
authors: Department of Orthopaedic Surgery, Shanghai Fengxian Central Hospital, No. 9588, NanFeng Road, Fengxian District, Shanghai 201400, China. haimzhu@126.com
authors: Haiming
authors: H
authors: Zhu
authors: Liang
authors: L
authors: Ding
authors: Haijun
authors: H
authors: Xiao
authors: Weifeng
authors: W
authors: Ni
authors: Feng
authors: F
authors: Xue
authors: Zhiming
authors: Z
authors: He
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood / Q000652:urine; D003300:Copper / Q000097:blood / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004967:Estrogens / Q000097:blood; D005260:Female; D005269:Femur / Q000187:drug effects / Q000502:physiology; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000502:physiology; D009929:Organ Size / Q000235:genetics; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects; D015032:Zinc / Q000097:blood / Q000652:urine
chemical_list: D004365:Drugs, Chinese Herbal; D004967:Estrogens; D010281:Parathyroid Hormone; D014020:Tissue Extracts; C575737:liuwei zhuanggu; D015675:Osteocalcin; D003300:Copper; D002116:Calcitonin; D015032:Zinc; D002118:Calcium