title: Repopulation of ganciclovir-resistant cytomegalovirus by wild-type virus.
abstract: We report a patient in whom ganciclovir (GCV)-resistant cytomegalovirus (CMV) was replaced by wild-type virus after discontinuation of GCV/valganciclovir and review other similar cases. Repopulation by wild-type virus may occur soon after discontinuation and may be fostered by discontinuing GCV altogether rather than continuing it in combination with foscarnet when treating patients with GCV-resistant CMV disease.
authors: Department of Laboratory Medicine and Medicine, University of California, San Francisco, San Francisco, CA 94143-0654, USA.
authors: W Lawrence
authors: WL
authors: Drew
authors: Catherine
authors: C
authors: Liu
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003587:Cytomegalovirus / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000601:surgery / Q000821:virology*; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000150:complications / Q000601:surgery / Q000821:virology*; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir