title: Effect of tea polyphenol on oxidative injury in S180 cells induced hepatocarcinoma mice.
abstract: The purpose of this study was to evaluate the antioxidant nature of tea polyphenol on S180 cells induced liver cancer in mice. In the present study, hepatocellular carcinoma was induced by tumor transplantation of liver in situ. The antitumor activity of tea polyphenol has been determined in vivo in hepatocellular carcinoma mice after treatment of drug (50, 100, 150 mg/kg body weight) by gavage for 20 days. Results showed that a significant increase in serum aspartate transaminase (AST), alkaline phosphatase (ALP), alanine aminotransfere (ALT), malondialdehyde (MDA) level, decrease in serum white blood cells (WBC), serum total protein (TP), albumin (ALB), A/G, tumor necrosis factor-α (TNF-α) and interferon-gamma (IFN-γ), liver reduced glutathione (GSH) levels were observed. In addition, the levels of enzymic and non-enzymic antioxidants were decreased when subjected to S180 cells induction. These altered enzyme levels were ameliorated significantly by administration of tea polyphenol at the concentration of 50, 100, 150 mg/kg body weight in drug-treated animals. These results indicate that the protective effect of tea polyphenol was associated with inhibition of MDA induced by S180 cells and to maintain the antioxidant enzyme levels.
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Bo-Kang
authors: BK
authors: Cui
authors: Department of Pharmocology, Guangzhou Institute for Drug Control, 23 Xizeng Road, Liwan District, Guangzhou 510160, China.
authors: Su
authors: S
authors: Liu
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Shu-Hong
authors: SH
authors: Li
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Jun
authors: J
authors: Wang
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Qi-Bo
authors: QB
authors: Wang
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Sheng-Ping
authors: SP
authors: Li
authors: Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China.|State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
authors: Xiao-Jun
authors: XJ
authors: Lin
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000737:chemistry / Q000627:therapeutic use*; D013662:Tea / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D059808:Polyphenols; D013662:Tea