title: Inhibitory effects of modafinil on emotional memory in mice.
abstract: Modafinil (MOD), a psychostimulant used to treat narcolepsy, excessive daytime sleepiness, and sleepiness due to obstructive sleep apnea, appears to promote a possible facilitatory effect on cognitive function. In the present study, we investigated the effects of the acute administration of MOD on the different steps of emotional memory formation and usage (acquisition, consolidation and retrieval) as well as the possible participation of the state-dependency phenomenon on the cognitive effects of this compound. Mice were acutely treated with 32, 64 or 128 mg/kg MOD before training or testing or immediately after training and were subjected to the plus-maze discriminative avoidance task. The results showed that although pre-training MOD administration did not exert any effects on learning, the doses of 32 or 64 mg/kg induced emotional memory deficits during testing. Still, the post-training acute administration of the higher doses of MOD (64 and 128 mg/kg) impaired associative memory consolidation. When the drug was administered pre-test, only the 32 mg/kg dose impaired the task retrieval. Importantly, the cognitive impairing effects induced by 32 mg/kg MOD were not related to the phenomenon of state-dependency. In all, our findings provide pre-clinical evidence of potential emotional memory amnesia induced by MOD. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
authors: Departamento de Psicobiologia, Universidade Federal de São Paulo, R. Napoleão de Barros 925, São Paulo, SP, Brazil.
authors: Helaine A
authors: HA
authors: Fernandes
authors: Karina A
authors: KA
authors: Zanin
authors: Camilla L
authors: CL
authors: Patti
authors: Raphael
authors: R
authors: Wuo-Silva
authors: Rita C
authors: RC
authors: Carvalho
authors: Luciano
authors: L
authors: Fernandes-Santos
authors: Lia R A
authors: LR
authors: Bittencourt
authors: Sergio
authors: S
authors: Tufik
authors: Roberto
authors: R
authors: Frussa-Filho
mesh_terms: D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D003072:Cognition Disorders / Q000139:chemically induced; D004193:Discrimination Learning / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D061212:Memory, Episodic; D051379:Mice; D000077408:Modafinil; D018697:Nootropic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D058573:Performance-Enhancing Substances / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D011897:Random Allocation; D012153:Retention, Psychology / Q000187:drug effects
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D018697:Nootropic Agents; D058573:Performance-Enhancing Substances; D000077408:Modafinil