title: Is extracapsular tumour spread a prognostic factor in patients with early breast cancer?
abstract: BACKGROUND
  This study searched for extra capsular tumour spread (ECS) as a prognostic factor for recurrence in terms of Disease Free Survival (DFS) and Overall Survival (OS).
  
  
  METHODS
  For this study, from a retrospective database of the Doubs cancer registry, 823 eligible women with node positive breast cancer treated from February 1984 to November 2000 were identified. The following factors were evaluated: ECS, numbers of involved nodes, histological tumour grade, tumour size, status of estrogen and progesterone receptors, and age of patient. A Cox proportional hazards method was used to search for significant factors related to OS and DFS length.
  
  
  RESULTS
  In the multivariate analysis, factors related to DFS length were found to be: tumour grade (aHR 0.76, 95 % CI 0.61-0.96, p = 0.02), ECS status (aHR 0.7, 95 % CI 0.49-0.96, p = 0.03), progesterone (PgR) status (aHR 0.63, 95 % CI 0.44-0.85 p = 0.008), number of nodes involved (aHR 0.75, 95 % CI 0.56-1, p = 0.05). The multivariate analysis for OS found as significant factors: tumour grade (aHR 0.76, 95 % CI 0.61-0.95; p = 0.02) and PgR status (aHR 0.8, 95 % CI 0.56-0.99, p = 0.02).
  
  
  CONCLUSIONS
  This study might suggest taking into account ECS status in the adjuvant decision-making process.
authors: Department of Medical Oncology, University Hospital of Besancon, Besançon, France. erion_dr@yahoo.com
authors: Erion
authors: E
authors: Dobi
authors: Fernando
authors: F
authors: Bazan
authors: Armelle
authors: A
authors: Dufresne
authors: Martin
authors: M
authors: Demarchi
authors: Cristian
authors: C
authors: Villanueva
authors: Loic
authors: L
authors: Chaigneau
authors: Philipe
authors: P
authors: Montcuquet
authors: Arben
authors: A
authors: Ivanaj
authors: Jean Loup
authors: JL
authors: Sautière
authors: Yolande
authors: Y
authors: Maisonnette-Escot
authors: Laurent
authors: L
authors: Cals
authors: Marie Paule
authors: MP
authors: Algros
authors: Anne-Sophie
authors: AS
authors: Woronoff
authors: Xavier
authors: X
authors: Pivot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D011980:Receptors, Progesterone