title: Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
abstract: Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer.
authors: Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603, Japan. eitsuka@nupals.ac.jp
authors: Takahiro
authors: T
authors: Eitsuka
authors: Kiyotaka
authors: K
authors: Nakagawa
authors: Yuichi
authors: Y
authors: Ono
authors: Naoto
authors: N
authors: Tatewaki
authors: Hiroshi
authors: H
authors: Nishida
authors: Tadao
authors: T
authors: Kurata
authors: Naoki
authors: N
authors: Shoji
authors: Teruo
authors: T
authors: Miyazawa
mesh_terms: D002277:Carcinoma / Q000378:metabolism*; D045744:Cell Line, Tumor; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006017:Glycolipids / Q000494:pharmacology*; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008956:Models, Chemical; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D010641:Phenotype; D010714:Phosphatidylethanolamines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D019098:Telomerase / Q000096:biosynthesis* / Q000378:metabolism; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D006017:Glycolipids; D008055:Lipids; C511949:N-(1,6-dideoxyfructopyranosyl)-1,3-dioleoyl-2-phosphatidylethanolamine; D010714:Phosphatidylethanolamines; D012333:RNA, Messenger; D013778:Tetrazolium Salts; D013844:Thiazoles; D019098:Telomerase; C022616:thiazolyl blue