title: Protective effects of salidroside from Rhodiola rosea on LPS-induced acute lung injury in mice.
abstract: Salidroside is a major component extracted from Rhodiola rosea. In this study, we investigated protective effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. In the mouse model, we found that pretreatment with a single 120 mg/kg dose of salidroside prior to the administration of intratracheal LPS induced a significant decrease in the W/D ratio and mouse myeloperoxidase activity of lung, reduction protein concentration, the number of total cells, neutrophils and macrophages in the bronchoalveolar lavage fluid. In addition, salidroside also inhibited the production of several inflammatory cytokines, including tumor necrosis factor-α, interleukin-6 (IL-6) and IL-1β, and the NF-κB DNA-binding activation after LPS challenge. These results indicated that salidroside possess a protective effect on LPS-induced ALI in mice.
authors: Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, People's Republic of China.
authors: Shuang
authors: S
authors: Guan
authors: Ying
authors: Y
authors: Xiong
authors: Bocui
authors: B
authors: Song
authors: Yu
authors: Y
authors: Song
authors: Dacheng
authors: D
authors: Wang
authors: Xiao
authors: X
authors: Chu
authors: Na
authors: N
authors: Chen
authors: Meixia
authors: M
authors: Huo
authors: Xuming
authors: X
authors: Deng
authors: Jing
authors: J
authors: Lu
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D016207:Cytokines; D005960:Glucosides; D008070:Lipopolysaccharides; D010636:Phenols; C009172:rhodioloside