title: Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity.
abstract: Seven known triterpene glycosides, 23-O-acetylshengmanol 3-O-α-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-β-D-xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside (3), cimiaceroside B (4), (23R,24S)-cimigenol 3-O-β-D-xylopyranoside (5), (23R,24R)-25-O-acetylcimigenol 3-O-β-D-xylopyranoside (6) and (23R,24S)-25-O-anhydrocimigenol 3-O-β-D-xylopyranoside (7) were isolated from the rhizomes of Cimicifuga heracleifolia. Their chemical structures were determined on the basis of spectroscopic analyses including 2D NMR. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 6 showed strong inhibitory activity with an IC₅₀ value of 7.7 µM while compound 3 was moderately active with an IC₅₀ value of 195.6 µM.
authors: College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea.
authors: Jung Hoon
authors: JH
authors: Lee
authors: To Dao
authors: TD
authors: Cuong
authors: Seung Jun
authors: SJ
authors: Kwack
authors: Ji Hyeon
authors: JH
authors: Seok
authors: Jong Kwon
authors: JK
authors: Lee
authors: Ja Young
authors: JY
authors: Jeong
authors: Mi-Hee
authors: MH
authors: Woo
authors: Jae Sue
authors: JS
authors: Choi
authors: Hyeong Kyu
authors: HK
authors: Lee
authors: Byung Sun
authors: BS
authors: Min
mesh_terms: D000818:Animals; D031885:Cimicifuga / Q000737:chemistry*; D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry; D012756:Sheep; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C578358:24-epi-24-O-acetylhydroshengmanol 3-O-beta-D-xylopyranoside; D003169:Complement Inactivator Proteins; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes; C012749:anticomplement