title: Abietane diterpenoids from Isodon inflexus.
abstract: Four abietane diterpenoids, inflexanin C, inflexanin D, inflexuside A and inflexuside B, were isolated from the aerial parts of Isodon inflexus. Their respective structures were established by NMR, mass spectrometry and CD as (+)-(1S,4R,5S,7S,8S,10S,13S)-1,7,18-trihydroxy-abieta-9(11)-ene-12-one 1-monoacetate, (+)-(1S,4R,5S,10S,13S)-1,18-dihydroxy-abieta-7,9(11)-diene-12-one 1-monoacetate, (-)-(1S,5S,10S,11R,13R)-1,11,13-trihydroxy-abieta-8-ene-7-one 1-O-β-D-glucopyranoside and (-)-(1S,5S,10S,11R,13R)-1,11,13-trihydroxy-abieta-8-ene-7-one 1-O-(2-O-coumaroyl)-β-D-glucopyranoside. All compounds showed strong inhibitory activity against nitric oxide (NO) production in RAW264.7 lipopolysaccaride (LPS)-activated macrophages.
authors: Marine College, Shandong University, Weihai 264209, People's Republic of China. wdxie@sdu.edu.cn
authors: Wei-Dong
authors: WD
authors: Xie
authors: Xia
authors: X
authors: Li
authors: Jiang-He
authors: JH
authors: Zhao
authors: Yong-Heng
authors: YH
authors: Liu
authors: Kyung Ho
authors: KH
authors: Row
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D002942:Circular Dichroism; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D037602:Isodon / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D045784:Abietanes; D016166:Free Radical Scavengers; D006027:Glycosides; D008070:Lipopolysaccharides; D009569:Nitric Oxide