title: In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Ménière's disease.
abstract: OBJECTIVE
  To study the correlation between the degree of endolymphatic hydrops as detected in vivo by magnetic resonance (MR) imaging and the auditory and vestibular function in patients with definite Ménière's disease.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Tertiary referral center for balance disorders.
  
  
  METHODS
  In this prospective study, 41 patients who fulfilled the criteria for definite unilateral Ménière's disease according to the American Association of Otolaryngology-Head and Neck Surgery and who showed a summating potential-to-action potential ratio of greater than 0.4 on electrocochleography were included. Intratympanic contrast-enhanced 3 Tesla MR imaging of the inner ear was performed using a 3D Inversion Recovery Turbo Spin Echo sequence. The degree of endolymphatic hydrops was graded on a Likert scale (0-3) in the cochlea and by vestibular endolymph space ratio in the vestibulum. The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, interaural amplitude ratios of vestibular evoked myogenic potentials, degree of horizontal semicircular canal paresis on caloric irrigation, and disease duration.
  
  
  RESULTS
  The degree of hearing loss and the disease duration correlated significantly with cochlear hydrops (r = 0.85; r = 0.34). Sacculus dysfunction was significantly correlated with vestibular hydrops (r = -0.47). There was no significant correlation between horizontal semicircular canal paresis and vestibular hydrops.
  
  
  CONCLUSIONS
  In patients with clinically and electrocochleographically confirmed definite Ménière's disease, the degree of MR morphological hydrops severity correlates significantly with impairment of hearing function and sacculus function.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Integrated Centre for Balance Disorders, Grosshadern Medical Centre, University of Munich, Munich, Germany. rguerkov@med.uni-muenchen.de
authors: Robert
authors: R
authors: Gürkov
authors: Wilhelm
authors: W
authors: Flatz
authors: Julia
authors: J
authors: Louza
authors: Michael
authors: M
authors: Strupp
authors: Birgit
authors: B
authors: Ertl-Wagner
authors: Eike
authors: E
authors: Krause
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response / Q000379:methods*; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D007758:Ear, Inner / Q000473:pathology*; D018159:Endolymphatic Hydrops / Q000209:etiology* / Q000473:pathology*; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000473:pathology*; D008875:Middle Aged; D012665:Semicircular Canals / Q000503:physiopathology; D058585:Vestibular Evoked Myogenic Potentials / Q000502:physiology; D014724:Vestibular Function Tests
chemical_list: D003287:Contrast Media; D005682:Gadolinium