title: Adolescent polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) can be identified in the adolescent years but is a process with genetic and epigenetic origins. Intrauterine growth retardation and premature adrenarche may precede the presentation of hyperandrogenism and oligo/anovulation. Other causes of hyperandrogenism and ovulatory dysfunction must be ruled out before PCOS is diagnosed. Obesity and insulin resistance often are associated features and greatly increase a girl's risk of developing metabolic syndrome and type 2 diabetes mellitus. Oral contraceptives, metformin, antiandrogens, and lifestyle modifications can have roles in alleviating the symptoms of PCOS and are reviewed in this article.
authors: University of Wisconsin, Madison, Wisconsin, USA. elconnor@pediatrics.wisc.edu
authors: Ellen Lancon
authors: EL
authors: Connor
mesh_terms: D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000726:Androgen Antagonists / Q000627:therapeutic use; D015992:Body Mass Index; D003276:Contraceptives, Oral / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism; D004412:Dysmenorrhea / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D007328:Insulin / Q000378:metabolism; D008019:Life Style; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D011627:Puberty / Q000502:physiology* / Q000523:psychology; D012307:Risk Factors
chemical_list: D000726:Androgen Antagonists; D003276:Contraceptives, Oral; D007004:Hypoglycemic Agents; D007328:Insulin