title: New insights into the roles of ncRNA in the STAT3 pathway.
abstract: STAT3 signaling has been linked to the development of various cancers and is widely recognized as a critical molecular target for cancer therapy. ncRNAs, especially miRNAs and lncRNAs, are acting as promising biomarkers and therapy targets implicated in tumor pathogenesis. This review focuses on the most up-to-date knowledge of miRNAs and lncRNAs, and their involvement with STAT3 signaling. The important miRNAs involved in the STAT3 pathway are summarized in a complex interaction network. The lncRNAs' potential for targeting STAT3 at post-transcriptional level was predicted based upon lncRNA-mRNA interaction. The current and potential STAT3-targeted therapeutics are also discussed.
authors: Department of Neurosurgery, Laboratory of Neuro-Oncology, Tianjin Medical University General Hospital, Tianjin 300052, People's Republic of China.
authors: Junxia
authors: J
authors: Zhang
authors: Anlin
authors: A
authors: Zhang
authors: Yingyi
authors: Y
authors: Wang
authors: Ning
authors: N
authors: Liu
authors: Yongping
authors: Y
authors: You
authors: Chunsheng
authors: C
authors: Kang
authors: Peiyu
authors: P
authors: Pu
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated; D050796:STAT3 Transcription Factor