title: Crystal precipitation and granulomatous inflammation in multiple organs after foscarnet therapy in a lung transplant recipient.
abstract: We present the case of a lung transplant recipient with disseminated crystal precipitation, and granulomatous and fibrinous inflammation after therapy with foscarnet (Foscavir; AstraZeneca, Zug, Switzerland) for recurring ganciclovir-resistant cytomegalovirus (CMV) reactivation. This is the first description of systemic crystal precipitation and granulomatous inflammation associated with foscarnet therapy with predominant involvement of the heart, kidneys and lungs.
authors: Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. verena.tischler@usz.ch
authors: Verena
authors: V
authors: Tischler
authors: Macé M
authors: MM
authors: Schuurmans
authors: Annette
authors: A
authors: Boehler
authors: Ariana
authors: A
authors: Gaspert
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003460:Crystallization; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D017245:Foscarnet / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced*; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D007674:Kidney Diseases / Q000139:chemically induced*; D008171:Lung Diseases / Q000139:chemically induced*; D016040:Lung Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced*
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet