title: Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials.
abstract: The development of novel biomaterials able to control cell activities and direct their fate is warranted for engineering functional biological tissues, advanced cell culture systems, single-cell diagnosis as well as for cell sorting and differentiation. It is well established that crosstalk at the cell-material interface occurs and this has a profound influence on cell behaviour. However, the complete deciphering of the cell-material communication code is still far away. A variety of material surface properties have been reported to affect the strength and the nature of the cell-material interactions, including biological cues, topography and mechanical properties. Novel experimental evidence bears out the hypothesis that these three different signals participate in the same material-cytoskeleton crosstalk pathway via adhesion plaque formation dynamics. In this review, we present the relevant findings on material-induced cell response along with the description of cell behaviour when exposed to arrays of signals-biochemical, topographical and mechanical. Finally, with the aid of literature data, we attempt to draw unifying elements of the material-cytoskeleton-cell fate chain.
authors: Center for Advanced Biomaterials for Health Care@CRIB, Istituto Italiano di Tecnologia and Interdisciplinary Research Center on Biomaterials, University of Naples Federico II, Napoli, Italy.
authors: Maurizio
authors: M
authors: Ventre
authors: Filippo
authors: F
authors: Causa
authors: Paolo A
authors: PA
authors: Netti
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D040542:Mechanotransduction, Cellular
chemical_list: D001672:Biocompatible Materials