title: Hepatocellular carcinoma arising in a testicular teratoma: a distinct and unrecognized secondary somatic malignancy.
abstract: We report an interesting case of testicular germ cell tumor with distinct seminomatous and teratomatous components. A rare development of secondary somatic malignancy in the form of hepatocellular carcinoma was observed. Immunohistochemically, hepatocellular cancer was positive for cytokeratin, hepatocyte paraffin-1 (HepPar-1), α-fetoprotein, glypican-3 (GPC-3), octamer-binding transcription factor 3/4 (Oct3/4), and Ki-67. In addition, adenocarcinoma and rhabdomyoblastic differentiation were also evident. Placental alkaline phosphatase (PLAP), Sal-like 4, and Oct3/4 were positive in seminoma. To the best of our knowledge, we have not found any such report of secondary development of hepatocellular carcinoma in a testicular teratoma. We believe that it is a rare, distinct phenomenon in germ cell tumors and deserves recognition.
authors: Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India. deepalijain76@gmail.com
authors: Deepali
authors: D
authors: Jain
authors: Suchi
authors: S
authors: Mittal
authors: Manu
authors: M
authors: Gupta
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D018239:Seminoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor