title: The transient effect of interictal spikes from a frontal focus on language-related gamma activity.
abstract: Interictal spike activity arising from an epileptic focus may cause transient subclinical changes in language function. We retrospectively studied four patients with a seizure focus of the left frontal lobe who underwent language mapping via electrocorticography. In three patients, we could group language task trials into 'spike' and 'non-spike' trials, based upon occurrence of spikes arising from the seizure onset zone during presentation of question stimuli. In one patient, we demonstrated a reduction in language-related gamma activity (80-100Hz) at one dorsal superior frontal site outside the seizure onset zone; reduction in mean peak amplitude of 58.4% of baseline reference (95% C.I.: 31.6% to 85.1%). This site was located near the seizure onset zone and was associated with the greatest spike rate among sites of similar function. This is the first preliminary study to show an effect of interictal spikes upon language-related gamma activity of the lateral frontal lobe.
authors: School of Medicine, Wayne State University, Detroit, MI 48201, USA.
authors: Erik C
authors: EC
authors: Brown
authors: Naoyuki
authors: N
authors: Matsuzaki
authors: Eishi
authors: E
authors: Asano
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007802:Language; D008297:Male; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult