title: Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer.
abstract: The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival.
authors: Medical Oncology Unit; Oncology Department; Azienda Ospedaliera Universitaria Senese; Siena, Italy.
authors: Pierpaolo
authors: P
authors: Correale
authors: Maria Saveria
authors: MS
authors: Rotundo
authors: Cirino
authors: C
authors: Botta
authors: Maria Teresa
authors: MT
authors: Del Vecchio
authors: Pierfrancesco
authors: P
authors: Tassone
authors: Pierosandro
authors: P
authors: Tagliaferri