title: Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum.
abstract: Cinnamic acid derivatives containing a 4-amino-7-chloroquinoline scaffold (blue) and substituted cinnamoyl building blocks (green) linked through an alkylamine chain (red) were found to have potent (11-59 nM) in vitro activities against erythrocytic chloroquine- resistant Plasmodium falciparum.
authors: Centro de Investigação em Química, Departamento de Química e Bioquímic, Faculdade de Ciências da Universidade do Porto, R. do Campo Alegre, 4169-007 Porto, Portugal.
authors: Bianca
authors: B
authors: Pérez
authors: Cátia
authors: C
authors: Teixeira
authors: Jiri
authors: J
authors: Gut
authors: Philip J
authors: PJ
authors: Rosenthal
authors: José R B
authors: JR
authors: Gomes
authors: Paula
authors: P
authors: Gomes
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry* / Q000494:pharmacology*; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D002934:Cinnamates; C029010:cinnamic acid; D002738:Chloroquine