title: Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure.
abstract: OBJECTIVE
  To ascertain the association of -3826 A/G polymorphism with blood pressure and different obesity markers.
  
  
  METHODS
  A total of 96 adult participants (49 males, 47 females) were studied. Anthropometric measurements and blood pressure were taken using standardized techniques. Obesity indices of body mass index (BMI), waist hip ratio (WHR), waist height ratio (WHtR) and grand mean thickness (GMT) were computed. For genetic analysis, DNA was extracted from 50 microL blood.
  
  
  RESULTS
  A statistically significant difference between various genotypes of UCP1 and BMI, GMT, systolic blood pressure, diastolic blood pressure was found among females. In GGC homozygote, blood pressure showed positive and significant association with fat percentage and GMT (P < .001). Waist circumference, WHR, WHtR and BMI also showed positive association with blood pressure in heterozygous and homozygous GG form.
  
  
  CONCLUSIONS
  This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
authors: Obesity Research Unit, Physiological Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi.
authors: Meenal
authors: M
authors: Dhall
authors: Madan Mohan
authors: MM
authors: Chaturvedi
authors: Umesh
authors: U
authors: Rai
authors: Satwanti
authors: S
authors: Kapoor
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D007194:India; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D000071256:Uncoupling Protein 1
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1