title: HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection.
abstract: The influence of HIV coinfection on plasma hepatitis C virus (HCV) RNA load has not been reliably evaluated. We analyzed plasma HCV RNA load in 396 HCV-monoinfected and 467 HIV/HCV-coinfected patients. Median HCV RNA concentrations (interquartile range) in HCV-monoinfected patients were 5.88 (5.3-6.2) log(10)IU/mL versus 5.96 (5.6-6.5) log(10)IU/mL in HIV/HCV-coinfected individuals (p=0.033) as determined with the Cobas Amplicor Test and 6.06 (5.4-5.7) log(10)IU/mL versus 6.3 (5.5-6.9) log(10)IU/mL (p=0.026) using the Cobas TaqMan System. The plasma HCV RNA load in patients with HIV infection and undetectable plasmatic HIV RNA was similar to that observed in HCV-monoinfected individuals [6.02 (5.45-6.61) log(10)IU/mL versus 6.01 (5.36-6.59) log(10)IU/mL, respectively (p=1.0)]. In conclusion, HIV coinfection tends to be associated with higher plasma HCV RNA load, however, the magnitude of the differences is small and this effect can be counterbalanced with antiviral therapy.
authors: Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Avenida de Bellavista S/N, 41014 Seville, Spain.
authors: Karin
authors: K
authors: Neukam
authors: Silvia
authors: S
authors: García-Rey
authors: Celia
authors: C
authors: Cifuentes
authors: Juan
authors: J
authors: Macías
authors: José A
authors: JA
authors: Mira
authors: María J
authors: MJ
authors: Vázquez
authors: Manuel
authors: M
authors: Parra-Sánchez
authors: José C
authors: JC
authors: Palomares
authors: Nicolás
authors: N
authors: Merchante
authors: Federico A
authors: FA
authors: Di Lello
authors: Juan A
authors: JA
authors: Pineda
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D012367:RNA, Viral