title: Multi-target drugs: the trend of drug research and development.
abstract: Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target-target and drug-drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future.
authors: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
authors: Jin-Jian
authors: JJ
authors: Lu
authors: Wei
authors: W
authors: Pan
authors: Yuan-Jia
authors: YJ
authors: Hu
authors: Yi-Tao
authors: YT
authors: Wang
mesh_terms: D055808:Drug Discovery / Q000191:economics / Q000639:trends*; D040541:Marketing / Q000191:economics; D004364:Pharmaceutical Preparations / Q000191:economics; D012106:Research / Q000191:economics / Q000639:trends*
chemical_list: D004364:Pharmaceutical Preparations