title: Physical training normalizes nucleotide hydrolysis and biochemical parameters in blood serum from streptozotocin-diabetic rats.
abstract: Ectonucleotidases and the nucleotide metabolism have been implicated as important regulators in diabetes disease. We evaluated the ectonucleotidase activities and biochemical parameters in blood serum of streptozotocin (STZ)-induced diabetic rats submitted a physical training protocol. We observed a raise in ATP, ADP, AMP and p-Nph-5'-TMP hydrolysis rate and in the levels of cholesterol and triglycerides in rat blood serum, after 30 days of diabetes induction. However, in serum of rats submitted a physical training protocol by forced swimming, both the nucleotide hydrolysis rate and the lipids levels returned to the control values. Considering that diabetes leads to multiple pathophysiological alterations, the modulations observed in ectonucleotidase activities may be part of the events involved in these alterations. Then the physical training is a very important way to control the vascular alterations developed in diabetes.
authors: Laboratório de Bioquímica, Centro de Pesquisa e Pós-Graduação, Centro Universitário Metodista do IPA - Porto Alegre, RS, Brazil.
authors: César Eduardo Jacintho
authors: CE
authors: Moritz
authors: Gustavo
authors: G
authors: Abreu-Vieira
authors: Camila
authors: C
authors: Piroli
authors: Priscylla Nunes
authors: PN
authors: De Senna
authors: Valesca Veiga
authors: VV
authors: Cardoso
authors: Márcia Rosangela
authors: MR
authors: Wink
authors: Ângela d'Avila
authors: Âd
authors: Harthmann
authors: Bárbara
authors: B
authors: Rücker
authors: Emerson André
authors: EA
authors: Casali
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy; D006868:Hydrolysis; D008297:Male; D009711:Nucleotides / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D009711:Nucleotides