title: Aging epigenetics: causes and consequences.
abstract: Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on genetic and environmental factors and, when it takes place in adult stem cells, it could play an important role in aging, although the underlying molecular mechanisms are still largely unknown.
authors: Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
authors: Covadonga
authors: C
authors: Huidobro
authors: Agustin F
authors: AF
authors: Fernandez
authors: Mario F
authors: MF
authors: Fraga
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology; D000375:Aging / Q000235:genetics*; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D057890:Epigenomics; D059647:Gene-Environment Interaction; D006657:Histones / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D011499:Protein Processing, Post-Translational; D034622:RNA Interference
chemical_list: D006657:Histones; D035683:MicroRNAs