title: Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1.
abstract: BACKGROUND
  It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs of aging is progressive gonadal dysfunction.
  
  
  METHODS
  To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating plasma levels of IGF-1, and 6-month-old bovine growth hormone transgenic (bGHTg) mice, with high circulating plasma levels of IGF-1. The ages of the Laron dwarf mutants employed in our studies were selected based on their overall survival (up to ~ 4 years for Laron dwarf mice and ~ 1 year for bGHTg mice).
  
  
  RESULTS
  Morphological analysis of the ovaries of mice that reached ~50% of their maximal life span revealed a lower biological age for the ovaries isolated from 2-year-old Laron dwarf mice than their normal-lifespan wild type littermates. By contrast, the ovarian morphology of increased in size 6 month old bGHTg mice was generally normal.
  
  
  CONCLUSIONS
  Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.
authors: Department of Physiology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland. sylwia@pum.edu.pl.
authors: Sylwia
authors: S
authors: Słuczanowska-Głąbowska
authors: Maria
authors: M
authors: Laszczyńska
authors: Katarzyna
authors: K
authors: Piotrowska
authors: Wojciech
authors: W
authors: Głąbowski
authors: John J
authors: JJ
authors: Kopchick
authors: Andrzej
authors: A
authors: Bartke
authors: Magda
authors: M
authors: Kucia
authors: Mariusz Z
authors: MZ
authors: Ratajczak