title: The role of miRNAs in the pathogenesis and diagnosis of B-cell lymphomas.
abstract: There is a demand to understand B-cell lymphoma pathogenesis better, to identify new markers, and to define multiple lymphoproliferative disorders more accurately. MicroRNAs (miRNAs) are regulators of protein translation, comprising a group of more than 1500 short noncoding single-strand RNA molecules of approximately 22 nucleotides in length. They are easily detectable in fresh or paraffin-embedded diagnostic tissue and serum. Expression of individual miRNAs and miRNA signatures allows specific cell-differentiation stages to be identified, and is a powerful diagnostic and prognostic method. Here we review what is known about the pathogenic relevance of miRNAs, and use of miRNAs for the diagnosis and prognosis of B-cell lymphomas. Most of the published data concern chronic lymphocytic lymphoma and diffuse large B-cell lymphoma, and implicate miRNAs in the pathogenesis of these diseases. They identify miRNAs that could be used for diagnosis, prognosis, or prediction of response to specific therapies.
authors: Hospital Universitario Marqués de Valdecilla (HUMV)-Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain;
authors: Lorena
authors: L
authors: Di Lisio
authors: Nerea
authors: N
authors: Martinez
authors: Santiago
authors: S
authors: Montes-Moreno
authors: Miguel
authors: M
authors: Piris-Villaespesa
authors: Margarita
authors: M
authors: Sanchez-Beato
authors: Miguel A
authors: MA
authors: Piris
mesh_terms: D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D035683:MicroRNAs