title: Reduced retinal nerve fiber layer thickness and macular volume in pediatric multiple sclerosis.
abstract: Retinal atrophy is well known in adult-onset multiple sclerosis but remains unexplored in children. We aimed to determine retinal nerve fiber layer thickness and macular volume in pediatric patients, with and without optic neuritis and their relations with visual evoked potentials. We also examined macular volume changes at month 12. Retinal nerve fiber layer thickness of all quadrants and macular volume were measured in 28 relapsing remitting multiple sclerosis eyes and 30 control eyes using optical coherence tomography and were found reduced in patients compared with controls. This reduction was more prominent in eyes with longer time interval from optic neuritis. Retinal nerve fiber thickness was lower in eyes with delayed visual evoked potentials. Visual evoked potential amplitudes were reduced in affected eyes compared to patients without optic neuritis. Macular volume reduced nonsignificantly in patients at month 12. Retinal atrophy occurs in pediatric multiple sclerosis, and previous optic neuritis accelerates this atrophy.
authors: Department of Pediatric Neurology, Dr.Behçet Uz Children's Hospital, İzmir, Turkey. drunsalyilmaz@yahoo.com
authors: Ünsal
authors: Ü
authors: Yilmaz
authors: Kivilcim
authors: K
authors: Gücüyener
authors: Döndü Melek
authors: DM
authors: Erin
authors: Zeliha
authors: Z
authors: Yazar
authors: Esra
authors: E
authors: Gürkaş
authors: Ayşe
authors: A
authors: Serdaroğlu
authors: Nermin
authors: N
authors: Tepe
authors: Ercan
authors: E
authors: Demir
mesh_terms: D000293:Adolescent; D002648:Child; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*; D009412:Nerve Fibers / Q000473:pathology*; D009902:Optic Neuritis / Q000150:complications / Q000473:pathology; D010372:Pediatrics; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012160:Retina / Q000473:pathology*; D055815:Young Adult