title: Pharmacogenomic approaches to study the effects of antihypertensive drugs.
abstract: Pharmacogenomic studies aim to clarify the role of various genes and their variations in relation to the effects of antihypertensive drugs to establish a personalized pharmacotherapeutic treatment based on a patient's genetic background. Until recently, there have been numerous pharmacogenetic/pharmacogenomic studies on antihypertensive drugs using candidate genes, but only a few genome-wide approaches have been completed. In this review article, we discuss current trends and future directions of pharmacogenomic studies on antihypertensive drugs.
authors: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan. kamide@geriat.med.osaka-u.ac.jp
authors: Kei
authors: K
authors: Kamide
authors: Yuhei
authors: Y
authors: Kawano
authors: Hiromi
authors: H
authors: Rakugi
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D057285:Precision Medicine
chemical_list: D000959:Antihypertensive Agents