title: Catch-up growth after long-term implementation and weaning from ketogenic diet in pediatric epileptic patients.
abstract: OBJECTIVE
  To assess the presence of growth retardation during long-term implementation of ketogenic diet (KD) among children with epilepsy, and verify the presence of catch-up growth in same patients 1 year after diet discontinuation.
  
  
  METHODS
  Retrospective chart review of 20 males and 20 females was performed and z scores of height, weight and body mass index was obtained at baseline, 2 years into KD, and 1 year after discontinuation of KD.
  
  
  RESULTS
  Our analysis revealed significant reduction in both height and weight gain among children with epilepsy after prolonged KD. After a year of diet discontinuation, significant catch-up growth was evident in both height and weight. In regard to specific subsets, ambulation had favorable influence on growth during KD and after diet discontinuation. Uncontrolled epilepsy, and younger age at the start of KD contributed a negative impact on a child's growth.
  
  
  CONCLUSIONS
  This preliminary observation into long-term growth pattern among recipients of KD will aid both health care providers and patients alike in planning for long-term care extending beyond the duration of dietary treatment.
authors: Division of Pediatric Neurology, Department of Pediatrics, Pediatric Epilepsy Clinic, Severance Children's Hospital, Epilepsy Research Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
authors: Jeong Tae
authors: JT
authors: Kim
authors: Hoon-Chul
authors: HC
authors: Kang
authors: Ji-Eun
authors: JE
authors: Song
authors: Min Jung
authors: MJ
authors: Lee
authors: Yun Jin
authors: YJ
authors: Lee
authors: Eun Joo
authors: EJ
authors: Lee
authors: Joon Soo
authors: JS
authors: Lee
authors: Heung Dong
authors: HD
authors: Kim
mesh_terms: D000293:Adolescent; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003131:Combined Modality Therapy; D055423:Diet, Ketogenic / Q000009:adverse effects*; D004351:Drug Resistance; D004827:Epilepsy / Q000178:diet therapy* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D051346:Mobility Limitation; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D015430:Weight Gain