title: Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?
abstract: Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.
authors: Dame Roma Mitchell Cancer Research Laboratory, School of Medicine, Hanson Institute and University of Adelaide, Adelaide SA 5000, Australia.
authors: T E
authors: TE
authors: Hickey
authors: J L L
authors: JL
authors: Robinson
authors: J S
authors: JS
authors: Carroll
authors: W D
authors: WD
authors: Tilley
mesh_terms: D000728:Androgens / Q000502:physiology*; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D005260:Female; D016147:Genes, Tumor Suppressor; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D042361:Mammary Glands, Human / Q000254:growth & development / Q000378:metabolism*; D009857:Oncogenes; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D000728:Androgens; D047628:Estrogen Receptor alpha; D006131:Growth Inhibitors; D011944:Receptors, Androgen