title: Innovations for combating dentin hypersensitivity: current state of the art.
abstract: Dentin hypersensitivity is a common dental complaint, and in severe cases it can impair eating, drinking, and even speaking, thus interfering with the normal daily life of an individual. Throughout years of research, there has been significant advancement in understanding dentin hypersensitivity, and various treatment regimens have been developed for combating the problem. The continued efforts have recently resulted in a novel technology that uses 8% arginine and calcium carbonate for treating dentin hypersensitivity. Formulations of oral care products using this technology--including toothpaste and prophylactic pastes--have demonstrated not only their effectiveness but also their ability to provide instant relief. This paper provides an overview of the etiology of dentin hypersensitivity, the discovery and development of measures for combating the problem, and the available data on the clinical efficacy of products based on 8% arginine and calcium carbonate.
authors: Center for Dental Research, Loma Linda University School of Dentistry, California, USA.
authors: Yiming
authors: Y
authors: Li
mesh_terms: D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003777:Dental Prophylaxis; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy* / Q000209:etiology; D019234:Dentinal Fluid / Q000502:physiology; D004338:Drug Combinations; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D057446:Hydrodynamics; D009566:Nitrates / Q000627:therapeutic use; D010710:Phosphates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use; D013324:Strontium / Q000627:therapeutic use; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D002364:Caseins; D057133:Dentin Desensitizing Agents; D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D014100:Toothpastes; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; C012980:fluorophosphate; D001120:Arginine; C025700:strontium chloride; D002119:Calcium Carbonate; D005459:Fluorides; C023844:potassium nitrate; D013324:Strontium