title: Kimura's disease and Behcet's syndrome in the same family--are they associated?
abstract: BACKGROUND
  Behcet's disease (BD) and Kimura's disease (KD) are two inflammatory diseases commonly found in Japan. In Israel, both diseases are quite rare. Recently, we encountered a family whose three siblings suffer from BD and an additional brother suffers from KD. This observation raised the question as to whether both diseases have a common underlying genetic basis.
  
  
  OBJECTIVE
  To describe this unique family and to search for possible common alleles in the IL10 gene between BD and KD, as several SNPs in this gene are known to be associated with BD.
  
  
  METHODS
  Three BD siblings and their brother with KD were interviewed and examined. Genomic DNA was prepared from blood samples taken from all nine members of the family. The DNA was genotyped for sequence variations of six SNPs on the IL10 gene.
  
  
  RESULTS
  The IL10 SNPs did not segregate with BD and KD suggesting that there was no association between the IL10 gene and these diseases in this family.
  
  
  CONCLUSIONS
  SNPs in the IL10 gene shown to be susceptibility factors in adult BD were not associated with BD in this family. The question regarding a possible common genetic basis for KD and BD requires further investigation.
authors: Department of Medicine, Rheumatology Unit, Hadassah-Hebrew University Medical Center Head, POB 12000, Jerusalem, Israel. eldad@hadassah.org.il
authors: Eldad
authors: E
authors: Ben-Chetrit
authors: Isabelle
authors: I
authors: Touitou
authors: Yakov
authors: Y
authors: Fellig
authors: Mouna
authors: M
authors: Barat-Houari
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000235:genetics*; D001528:Behcet Syndrome / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D016753:Interleukin-10