title: Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in Spain.
abstract: BACKGROUND
  Betalactam (BL) immediate-type allergy is influenced by environmental and genetic determinants, as illustrated by differences in worldwide prevalence and ethnicity from a same area and by associations with genes related to atopy.
  
  
  OBJECTIVE
  To evaluate the association of atopy with BL allergy.
  
  
  METHODS
  We measured specific Immunoglobulin E (IgE) against prevalent allergens and genetic predictors of atopy, IL13, IL4, IL4RA, IL4, and TNFA, in 340 patients and 340 controls from South of Spain.
  
  
  RESULTS
  Total IgE and IgE against mites were at higher concentration in patients. Patients with high total IgE and IgE against prevalent allergens had a slower decrease in BL IgE than nonatopic patients. IL4RA I50V and Q551R were associated with IgE against prevalent allergens and total IgE, respectively, and were also predictors of BL allergy.
  
  
  CONCLUSIONS
  Interacting determinants of atopy, total IgE, IgE against prevalent allergens, and IL4RA polymorphisms, contribute to the high prevalence of BL allergy in South of Spain.
authors: Institut National de la Santé et de la Recherche Médicale, Nutrition-Génétique-Exposition aux risques environnementaux, Faculté de Médecine et Centre Hospitalier Universitaire, Nancy-Université, France.
authors: J A
authors: JA
authors: Cornejo-García
authors: R-M
authors: RM
authors: Guéant-Rodriguez
authors: M J
authors: MJ
authors: Torres
authors: N
authors: N
authors: Blanca-Lopez
authors: D
authors: D
authors: Tramoy
authors: A
authors: A
authors: Romano
authors: M
authors: M
authors: Blanca
authors: J-L
authors: JL
authors: Guéant
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D000818:Animals; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D015995:Prevalence; D013030:Spain / Q000453:epidemiology; D047090:beta-Lactams / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000485:Allergens; C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D047090:beta-Lactams; D007073:Immunoglobulin E