title: Synthesis and in vitro antitumor activity of novel scopoletin derivatives.
abstract: Twenty scopoletin derivatives were developed by a systematic combinatorial chemical approach and their chemical structures were confirmed by MS, IR, (1)H NMR spectra and elemental analysis. Primary screening against mammary (MCF-7 and MDA-MB 231) and colon (HT-29) carcinoma cells indicated that five compounds (8d, 8g, 8j, 11b and 11g) displayed high antitumor potencies with IC(50) values below 20 μM whereas scopoletin showed IC(50) values above 100 μM. Moreover, the most promising compound 11g was more active than 5-fluorouracil. These results clearly indicated that the modification of the scopoletin structure could greatly increase its antitumor activity in vitro.
authors: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.
authors: Wukun
authors: W
authors: Liu
authors: Jie
authors: J
authors: Hua
authors: Jinpei
authors: J
authors: Zhou
authors: Huibin
authors: H
authors: Zhang
authors: Haiyang
authors: H
authors: Zhu
authors: Yanhua
authors: Y
authors: Cheng
authors: Ronald
authors: R
authors: Gust
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D012603:Scopoletin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D012603:Scopoletin