title: Tuberculosis: finding a new potential antimycobacterium derivative in a aldehyde-arylhydrazone-oxoquinoline series.
abstract: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis, which remains a serious public health problem. The emergence of resistant bacterial strains has continuously increased and new treatment options are currently in need. In this work, we identified a new potential aldehyde-arylhydrazone-oxoquinoline derivative (4e) with interesting chemical structural features that may be important for designing new anti-TB agents. This 1-ethyl-N'-[(1E)-(5-nitro-2-furyl)methylene]-4-oxo-1,4-dihydroquinoline-3-carbohydrazide (4e) presented an in vitro active profile against M. tuberculosis H37Rv strain (minimum inhibitory concentration, MIC = 6.25 μg/mL) better than other acylhydrazones described in the literature (MIC = 12.5 μg/mL) and close to other antitubercular agents currently on the market. The theoretical analysis showed the importance of several structural features that together with the 5-nitro-2-furyl group generated this active compound (4e). This new compound and the analysis of its molecular properties may be useful for designing new and more efficient antibacterial drugs.
authors: Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Outeiro de São João Baptista, Niterói, RJ 24020-141, Brazil.
authors: Fernanda
authors: F
authors: da C Santos
authors: Helena C
authors: HC
authors: Castro
authors: Maria Cristina S
authors: MC
authors: Lourenço
authors: Paula A
authors: PA
authors: Abreu
authors: Pedro N
authors: PN
authors: Batalha
authors: Anna C
authors: AC
authors: Cunha
authors: Guilherme S L
authors: GS
authors: Carvalho
authors: Carlos R
authors: CR
authors: Rodrigues
authors: Cid A
authors: CA
authors: Medeiros
authors: Simone D
authors: SD
authors: Souza
authors: Vitor F
authors: VF
authors: Ferreira
authors: Maria C B V
authors: MC
authors: de Souza
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006835:Hydrazones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000995:Antitubercular Agents; D006835:Hydrazones; D015363:Quinolones