title: The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids.
abstract: The first asymmetric aza-Friedel-Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
authors: Jingchao
authors: J
authors: Feng
authors: Wenjin
authors: W
authors: Yan
authors: Dong
authors: D
authors: Wang
authors: Peng
authors: P
authors: Li
authors: Quantao
authors: Q
authors: Sun
authors: Rui
authors: R
authors: Wang
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D000078183:Oxindoles; D010756:Phosphoric Acids / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C551521:3-amino-2-oxindole; D007097:Imines; D007211:Indoles; D009570:Nitriles; D000078183:Oxindoles; D010756:Phosphoric Acids; D011758:Pyrroles; C542835:ketimine