title: Polymeric nucleic acid carriers: current issues and novel design approaches.
abstract: To deliver nucleic acids including plasmid DNA (pDNA) and short interfering RNA (siRNA), polymeric gene carriers equipped with various functionalities have been extensively investigated. The functionalities of these polymeric vectors have been designed to overcome various extracellular and intracellular hurdles that nucleic acids and their carriers encounter during their journey from injection site to intracellular target site. This review briefly introduces known extracellular and intracellular issues of nucleic acid delivery and their solution strategies. We examine significant yet overlooked factors affecting nucleic acid delivery (e.g., microenvironmental pH, polymer/siRNA complexation, and pharmaceutical formulation) and highlight our reported approaches to solve these problems.
authors: Department of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
authors: Han Chang
authors: HC
authors: Kang
authors: Kang Moo
authors: KM
authors: Huh
authors: You Han
authors: YH
authors: Bae
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002412:Cations; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D004355:Drug Stability; D004705:Endocytosis / Q000235:genetics; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D009696:Nucleic Acids / Q000008:administration & dosage* / Q000235:genetics; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D014162:Transfection
chemical_list: D001672:Biocompatible Materials; D002412:Cations; D004337:Drug Carriers; D009696:Nucleic Acids; D011108:Polymers