title: Quality of life in clinically stable adult cystic fibrosis out-patients: associations with daytime sleepiness and sleep quality.
abstract: BACKGROUND
  Patients with cystic fibrosis (CF) may suffer from sleep disturbances and reduced health-related quality of life (HRQoL). However, the relationships of daytime sleepiness and sleep quality to HRQoL in CF have not yet been investigated.
  
  
  METHODS
  55 adult CF out-patients free from a pulmonary exacerbation were prospectively enrolled in this study. Questionnaires were used to assess disease-specific HRQoL (German version of the revised Cystic Fibrosis Questionnaire for adults, CFQ18 + R), daytime sleepiness (Epworth Sleepiness Scale, ESS) and sleep quality (Pittsburgh Sleep Quality Index, PSQI). 30 age- and sex-matched healthy volunteers served as a control group.
  
  
  RESULTS
  The prevalence of daytime sleepiness was higher in the CF than in the control group (ESS > 10; n = 11 [20%] vs. n = 2 [6.7%]; p < 0.01) as was reduced sleep quality (PSQI > 5; n = 21 [38.2%] vs. n = 1 [3.3%]; p < 0.01). Multiple regression analysis including age, gender, body mass index, lung function and pseudomonas status showed that higher PSQI scores significantly correlated with lower CFQ18 + R scores for vitality, emotional functioning, social, role, eating disturbances and digestive symptoms.
  
  
  CONCLUSIONS
  In clinically stable adult CF out-patients self-reported daytime sleepiness and poor sleep quality are more common than in age and sex-matched healthy controls. In addition, impaired sleep quality is related to reduced disease-specific HRQoL in CF.
authors: Department of Sleep Medicine & Adult CF Service, University of Giessen Lung Center, Klinik-Str. 33, 35392 Giessen, Germany.
authors: Anna
authors: A
authors: Bouka
authors: Henning
authors: H
authors: Tiede
authors: Linda
authors: L
authors: Liebich
authors: Rio
authors: R
authors: Dumitrascu
authors: Cornelia
authors: C
authors: Hecker
authors: Frank
authors: F
authors: Reichenberger
authors: Konstantin
authors: K
authors: Mayer
authors: Werner
authors: W
authors: Seeger
authors: Richard
authors: R
authors: Schulz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002940:Circadian Rhythm; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology; D014797:Vital Capacity / Q000502:physiology