title: Th17 and interleukin 23 in the pathogenesis of psoriatic arthritis and spondyloarthritis.
abstract: Psoriatic arthritis and spondyloarthritis (SpA) are complex immune-mediated diseases affecting peripheral and axial joints. T cells have been considered fundamental in triggering the disease and maintaining the process in the chronic phase. The recent discovery of the CD4+ Th17 lymphocyte subset and the interleukin 23/interleukin 17 axis has further contributed to the definition of unknown pathways, challenging previous models and the role of Th1/Th2 T cells in immune mediated diseases, including SpA.
authors: Rheumatology Unit, Department of Medical Sciences, Policlinico of the University of Cagliari, Monserrato, Cagliari, Italy. cauli@medicina.unica.it
authors: Alberto
authors: A
authors: Cauli
authors: Alessandro
authors: A
authors: Mathieu
mesh_terms: D000818:Animals; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053759:Interleukin-23 / Q000378:metabolism*; D007596:Joints / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction; D025242:Spondylarthropathies / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D053759:Interleukin-23