title: Proteolytic control of mitochondrial function and morphogenesis.
abstract: Mitochondrial proteostasis depends on a hierarchical system of tightly controlled quality surveillance mechanisms. Proteases within mitochondria take center stage in this network. They eliminate misfolded and damaged proteins and ensure the biogenesis and morphogenesis of mitochondria by processing or degrading short-lived regulatory proteins. Mitochondrial gene expression, the mitochondrial phospholipid metabolism and the fusion of mitochondrial membranes are under proteolytic control. Furthermore, in response to stress and mitochondrial dysfunction, proteolysis inhibits fusion and facilitates mitophagy and apoptosis. Defining these versatile activities of mitochondrial proteases will be pivotal for understanding the pathogenesis of various neurodegenerative disorders associated with defective mitochondria-associated proteolysis. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.
authors: University of Cologne, Cologne, Germany.
authors: Ruchika
authors: R
authors: Anand
authors: Thomas
authors: T
authors: Langer
authors: Michael James
authors: MJ
authors: Baker
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D063154:Mitochondrial Dynamics / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D063306:Mitophagy / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology; D055550:Protein Stability; D059748:Proteolysis
chemical_list: D024101:Mitochondrial Proteins