title: Clinicopathologic features of gastrointestinal tract involvement of anaplastic large cell lymphoma.
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of gastrointestinal tract involvement of anaplastic large cell lymphoma (ALCL).
  
  
  METHODS
  The clinicopathological features of four patients with ALCL that involved gastrointestinal tract were retrospectively analyzed using immunohistochemical study, T-cell receptor gene rearrangement analysis, and evaluation for Epstein Barr virus infection status.
  
  
  RESULTS
  Most tumor cells in all these four cases are large and highly pleomorphic, and all four cases were classified as the common pattern ALCL. Tumor cells in all four tumors expressed CD30, and expressed at least one cytotoxic maker. Two patients were confirmed to be with anaplastic lymphoma kinase (ALK)-positive ALCL, and four patients were negative during in situ hybridization for Epstein-Barr virus-encoded RNA but showed clonal T-cell receptor gene rearrangement.
  
  
  CONCLUSIONS
  Gastrointestinal tract involvement of ALCL has the unique clinicopathological features.
authors: Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors: Jian
authors: J
authors: Sun
authors: Jiao-lin
authors: JL
authors: Zhou
authors: Jie
authors: J
authors: Chen
authors: Chao-hui
authors: CH
authors: Lu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D020031:Epstein-Barr Virus Infections; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen