title: Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men.
abstract: BACKGROUND
  African Americans suffer disproportionately from diabetes and cardiovascular disease and are significantly more likely to have suboptimal concentrations of circulating 25-hydroxyvitamin D [25(OH)D]. The results of epidemiologic and observational studies suggest that there is a link between vitamin D deficiency and the risk of cardiometabolic disorders, which underscores the importance of maintaining healthy concentrations of 25(OH)D.
  
  
  OBJECTIVE
  The objective was to investigate whether daily supplementation with 4000 IU vitamin D(3) for 1 y would eliminate any disparities in circulating concentrations of 25(OH)D between African American and white men.
  
  
  METHODS
  Serum concentrations of 25(OH)D were measured every 2 mo in 47 subjects who received a daily oral dose of 4000 IU vitamin D(3) for 1 y.
  
  
  RESULTS
  More than 90% of African Americans had serum concentrations of 25(OH)D <32 ng/mL, and approximately two-thirds had serum concentrations <20 ng/mL. Furthermore, there were significant disparities in serum concentrations of 25(OH)D between African American and white men. Supplementation with 4000 IU/d for 1 y eliminated any significant differences in circulating concentrations of 25(OH)D between African American and white men.
  
  
  CONCLUSIONS
  The results of this clinical study show the feasibility and efficacy of this approach in the elimination of hypovitaminosis D, which is a widespread health disparity among African Americans. This trial was registered at clinicaltrials.gov as NCT01045109.
authors: Division of Biostatistics and Epidemiology, Department of Medicine, Medical University of South Carolina, Charleston, USA.
authors: Elizabeth
authors: E
authors: Garrett-Mayer
authors: Carol L
authors: CL
authors: Wagner
authors: Bruce W
authors: BW
authors: Hollis
authors: Mark S
authors: MS
authors: Kindy
authors: Sebastiano
authors: S
authors: Gattoni-Celli
mesh_terms: D001741:Black or African American; D000368:Aged; D015992:Body Mass Index; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000208:ethnology / Q000503:physiopathology; D044465:White People
chemical_list: D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D