title: Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.
abstract: Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.
authors: Kieler Wirkstoff-Zentrum (KiWiZ) at the Helmholtz-Zenrum für Ozeanforschung GEOMAR , Am Kiel-Kanal 44, 24106 Kiel, Germany.
authors: Birgit
authors: B
authors: Ohlendorf
authors: Dirk
authors: D
authors: Schulz
authors: Arlette
authors: A
authors: Erhard
authors: Kerstin
authors: K
authors: Nagel
authors: Johannes F
authors: JF
authors: Imhoff
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*; D016959:Xanthomonas campestris / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D010619:Phenazines; C575775:geranylphenazinediol