title: Prefrontal cortex controls human balance during overground ataxic gait.
abstract: OBJECTIVE
  1) to verify if prefrontal cortex (PFC) is activated during over ground walking in ataxic patients, 2) to correlate the clinical parameters of gait with the PFC activation patterns.
  
  
  METHODS
  Fourteen patients and 20 healthy subjects were studied. Ataxia was assessed by the Scale for the Assessment and Rating of Ataxia (SARA). A 2-channel near-infrared system was used to investigate the changes in oxygenated ([O2Hb]t) and deoxygenated ([HHb]t) hemoglobin concentrations on the PFC during gait. [O2Hb] baseline-corrected activation values ([O2Hb]c) were calculated by the difference between [O2Hb]t and [O2Hb] during upright posture ([O2Hb]b).
  
  
  RESULTS
  [O2Hb]t was increased for both channels (respectively p < 0.01 and p = 0.01) only in the patients. No variation was observed in [HHB]t. The correlation coefficient between [O2Hb]c and the SARA gait score was respectively r: 0.878 (p < 0.01) and r: 0.839 (p < 0.01) for the right and left PFC, between [O2Hb]c and the SARA stance score respectively r: 0.893 (p < 0.01) and r: 0.832 (p < 0.01).
  
  
  CONCLUSIONS
  During over ground gait PFC is bilaterally activated in patients with severe chronic ataxia. These findings may be associated with compensatory mechanisms which are involved in severe conditions when other nervous centers controlling balance are functionally not efficient.
authors: Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy. p.caliandro@rm.unicatt.it
authors: Pietro
authors: P
authors: Caliandro
authors: Marcella
authors: M
authors: Masciullo
authors: Luca
authors: L
authors: Padua
authors: Chiara
authors: C
authors: Simbolotti
authors: Gabriele
authors: G
authors: Di Sante
authors: Giuseppina
authors: G
authors: Russo
authors: Claudia
authors: C
authors: Garattini
authors: Gabriella
authors: G
authors: Silvestri
authors: Paolo M
authors: PM
authors: Rossini
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020234:Gait Ataxia / Q000473:pathology* / Q000503:physiopathology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000378:metabolism; D004856:Postural Balance / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D017397:Prefrontal Cortex / Q000378:metabolism / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared; D013223:Statistics as Topic
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin