title: Chemical characterization and evaluation of the hypoglycemic effect of fructooligosaccharides from Psacalium decompositum.
abstract: Psacalium decompositum (Gray) H.E. Rob. & Brett (Asteraceae), popularly known as "matarique," is a medicinal plant used in Mexico for the empirical treatment of diabetes mellitus. Previous studies with P. decompositum roots demonstrated that an aqueous fraction containing carbohydrates (WMP-fraction) exhibited a notable hypoglycemic effect in experimental animals. However, studies to identify these carbohydrates have not yet been performed. The goal of this investigation was to isolate and characterize the principal compounds in the WMP-fraction by spectroscopic and spectrometric analysis. Additionally, we sought to evaluate the hypoglycemic effect of these compounds in healthy and alloxan-induced diabetic mice. The results show that the chemical structures of the major compounds in the WMP-fraction correspond with fructan-type oligosaccharides and have a hypoglycemic effect in healthy and diabetic mice.
authors: Universidad Nacional Autonoma de Mexico.
authors: Manuel
authors: M
authors: Jimenez-Estrada
authors: Hector
authors: H
authors: Merino-Aguilar
authors: Adriana
authors: A
authors: Lopez-Fernandez
authors: Nadia A
authors: NA
authors: Rojano-Vilchis
authors: Ruben
authors: R
authors: Roman-Ramos
authors: Francisco Javier
authors: FJ
authors: Alarcon-Aguilar
mesh_terms: D000496:Alloxan; D000818:Animals; D019659:Asteraceae; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008800:Mexico; D051379:Mice; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010946:Plants, Medicinal; D027343:Rhizome; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009844:Oligosaccharides; D010936:Plant Extracts; D000496:Alloxan