title: Maternity and lung transplantation: cases in Spain.
abstract: We contacted and analyzed the data of 18 lung transplant recipients who had had children. The complications we detected included: hypertension (50%), diabetes mellitus (21%), preeclampsia (13%), infection (21%), rejection (30%), loss of graft function (23%) and a lower percentage of live births than in transplant recipients of other organs. Other aspects to keep in mind are: the potential risk for fetal alterations (caused by drugs used as prophylaxis against rejection crossing the placental barrier); greater risk for infection and alterations in drug levels due to changes in metabolism typical of pregnancy and postpartum period. We describe the two cases in Spain of female lung transplant recipients who have had children after transplantation. Although pregnancy in these cases can have a similar evolution as in non-transplanted women, doctors should recommend their transplanted patients to avoid becoming pregnant, while explaining the high risk of both fetal and maternal morbidity and mortality after transplantation.
authors: Unidad de Trasplante Pulmonar, Servicio de Neumología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. nmlzgf@humv.es
authors: Felipe
authors: F
authors: Zurbano
authors: Francisco
authors: F
authors: López
authors: Inocencia
authors: I
authors: Fornet
authors: José Ramón
authors: JR
authors: de Miguel
authors: Javier
authors: J
authors: Segovia
authors: Piedad
authors: P
authors: Ussetti
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000139:chemically induced / Q000151:congenital; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology; D006330:Heart Defects, Congenital / Q000601:surgery; D016041:Heart-Lung Transplantation; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D006976:Hypertension, Pulmonary / Q000601:surgery; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced; D017563:Lung Diseases, Interstitial / Q000601:surgery; D016040:Lung Transplantation; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000453:epidemiology; D018566:Pregnancy, High-Risk; D013030:Spain / Q000453:epidemiology; D017741:Survivors; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus