title: Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
abstract: The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster.
authors: INBIOTEC (Instituto de Biotecnología de León), Parque Científico de León, León, Spain.
authors: Carlos
authors: C
authors: Barreiro
authors: Carlos
authors: C
authors: Prieto
authors: Alberto
authors: A
authors: Sola-Landa
authors: Elena
authors: E
authors: Solera
authors: Miriam
authors: M
authors: Martínez-Castro
authors: Rosario
authors: R
authors: Pérez-Redondo
authors: Carlos
authors: C
authors: García-Estrada
authors: Jesús F
authors: JF
authors: Aparicio
authors: Lorena T
authors: LT
authors: Fernández-Martínez
authors: Javier
authors: J
authors: Santos-Aberturas
authors: Zahra
authors: Z
authors: Salehi-Najafabadi
authors: Antonio
authors: A
authors: Rodríguez-García
authors: Andreas
authors: A
authors: Tauch
authors: Juan F
authors: JF
authors: Martín
mesh_terms: D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D016680:Genome, Bacterial; D007166:Immunosuppressive Agents / Q000378:metabolism*; D008969:Molecular Sequence Data; D013302:Streptomyces / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D016559:Tacrolimus / Q000378:metabolism*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus