title: Cytotoxic effect of eudesmanolides isolated from flowers of Tanacetum vulgare ssp. siculum.
abstract: A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects.
authors: Department of Molecular and Biomolecular Science and Technology (STeMBio), Organic Chemistry Section, Palermo University, Viale delle Scienze, Palermo 90128, Italy. sergio.rosselli@unipa.it
authors: Sergio
authors: S
authors: Rosselli
authors: Maurizio
authors: M
authors: Bruno
authors: Francesco Maria
authors: FM
authors: Raimondo
authors: Vivienne
authors: V
authors: Spadaro
authors: Mehmet
authors: M
authors: Varol
authors: Ayşe Tansu
authors: AT
authors: Koparal
authors: Antonella
authors: A
authors: Maggio
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003124:Colorimetry; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031203:Tanacetum / Q000737:chemistry*
chemical_list: D012717:Sesquiterpenes; C476916:eudesmanolide