title: Protein carbonylation and metabolic control systems.
abstract: Oxidative stress is linked to the production of reactive lipid aldehydes that non-enzymatically alkylate cysteine, histidine, or lysine residues in a reaction termed protein carbonylation. Reactive lipid aldehydes and their derivatives are detoxified via a variety of phase I and phase II systems, and when antioxidant defenses are compromised or oxidative conditions are increased, protein carbonylation is increased. The resulting modification has been implicated as causative in a variety of metabolic states including neurodegeneration, muscle wasting, insulin resistance, and aging. Although such modifications usually result in loss of protein function, protein carbonylation may be regulatory and activate signaling pathways involved in antioxidant biology and cellular homeostasis.
authors: Department of Biochemistry, Molecular Biology, and Biophysics, The University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
authors: Jessica M
authors: JM
authors: Curtis
authors: Wendy S
authors: WS
authors: Hahn
authors: Eric K
authors: EK
authors: Long
authors: Joel S
authors: JS
authors: Burrill
authors: Edgar A
authors: EA
authors: Arriaga
authors: David A
authors: DA
authors: Bernlohr
mesh_terms: D000375:Aging; D000447:Aldehydes / Q000378:metabolism; D000975:Antioxidants; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D050216:Metabolic Detoxication, Phase I / Q000502:physiology; D050217:Metabolic Detoxication, Phase II / Q000502:physiology; D008660:Metabolism; D009133:Muscular Atrophy; D009410:Nerve Degeneration; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D050050:Protein Carbonylation / Q000502:physiology*
chemical_list: D000447:Aldehydes; D000975:Antioxidants