title: Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis.
abstract: The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 - observed only in four no- GCD patients - groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. In conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome.
authors: Department of Neurology, Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil. rafaelscarpa@uol.com.br
authors: Rafael Scarpa
authors: RS
authors: da Costa Neves
authors: Anaclara Prada
authors: AP
authors: Jardim
authors: Luís Otávio
authors: LO
authors: Caboclo
authors: Carmen
authors: C
authors: Lancellotti
authors: Taissa Ferrari
authors: TF
authors: Marinho
authors: Ana Paula
authors: AP
authors: Hamad
authors: Murilo
authors: M
authors: Marinho
authors: Ricardo
authors: R
authors: Centeno
authors: Esper Abrão
authors: EA
authors: Cavalheiro
authors: Carla Alessandra
authors: CA
authors: Scorza
authors: Elza Márcia
authors: EM
authors: Targas Yacubian
mesh_terms: D000328:Adult; D038481:Anterior Temporal Lobectomy; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009474:Neurons / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012598:Sclerosis / Q000150:complications / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome