title: Basal cell carcinoma with spontaneous regression: a case report and immunohistochemical study.
abstract: Spontaneous regression of basal cell carcinoma (BCC) is rare, and characterized by various tumor-infiltrating lymphocytes (TILs) in the tumor. A previous report suggested that these infiltrated lymphocytes consist of type 1 helper T cells, but no detailed phenotypical analysis of other TILs has been demonstrated yet. In this report, we describe an 84-year-old Japanese patient with spontaneous regression of BCC. In the present case, we investigated the immunohistochemical profiles of TILs, not only focusing on the cytotoxic T cells, but the profiles of immunosuppressive cells, such as regulatory T cells and tumor-associated macrophages. Our present study sheds light on the immunological mechanisms of tumor rejection in human BCC.
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Taku
authors: T
authors: Fujimura
authors: Aya
authors: A
authors: Kakizaki
authors: Yumi
authors: Y
authors: Kambayashi
authors: Setsuya
authors: S
authors: Aiba