title: Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
abstract: Pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones were evaluated as corticotropin-releasing factor-1 receptor antagonists. The synthesis, SAR studies and pharmacokinetic evaluation of these analogs are described herein.
authors: Neuroscience Discovery Chemistry, Research and Development, Bristol-Myers Squibb Co, Wallingford, CT 06492, United States. carolyn.dzierba@bms.com
authors: Carolyn D
authors: CD
authors: Dzierba
authors: Thais M
authors: TM
authors: Sielecki
authors: Argyrios G
authors: AG
authors: Arvanitis
authors: Amy
authors: A
authors: Galka
authors: Tricia L
authors: TL
authors: Johnson
authors: Amy G
authors: AG
authors: Takvorian
authors: Maria
authors: M
authors: Rafalski
authors: Padmaja
authors: P
authors: Kasireddy-Polam
authors: Shikha
authors: S
authors: Vig
authors: Bireshwar
authors: B
authors: Dasgupta
authors: Ge
authors: G
authors: Zhang
authors: Thaddeus F
authors: TF
authors: Molski
authors: Harvey
authors: H
authors: Wong
authors: Robert C
authors: RC
authors: Zaczek
authors: Nicholas J
authors: NJ
authors: Lodge
authors: Andrew P
authors: AP
authors: Combs
authors: Paul J
authors: PJ
authors: Gilligan
authors: George L
authors: GL
authors: Trainor
authors: Joanne J
authors: JJ
authors: Bronson
authors: John E
authors: JE
authors: Macor
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D006207:Half-Life; D011621:Pteridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D000099052:CRF Receptor, Type 1
chemical_list: D014151:Anti-Anxiety Agents; D011621:Pteridines; D011719:Pyrazines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1