title: Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity.
abstract: This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250-300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings.
authors: Department of Chemistry, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors: Ahmed A
authors: AA
authors: Elzatahry
authors: Abdullah M
authors: AM
authors: Al-Enizi
authors: Elsayed Ahmed
authors: EA
authors: Elsayed
authors: Rachel R
authors: RR
authors: Butorac
authors: Salem S
authors: SS
authors: Al-Deyab
authors: Mohammad A M
authors: MA
authors: Wadaan
authors: Alan H
authors: AH
authors: Cowley
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055664:Electrochemical Techniques / Q000379:methods; D005658:Fungi / Q000187:drug effects; D017612:Gold Compounds / Q000737:chemistry / Q000494:pharmacology; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size
chemical_list: D000900:Anti-Bacterial Agents; D017612:Gold Compounds; C038016:gold chloride; C030011:carbene; D008697:Methane