title: White matter abnormalities associated with disruptive behavior disorder in adolescents with and without attention-deficit/hyperactivity disorder.
abstract: Disruptive behavior disorders (DBD) are among the most commonly diagnosed mental disorders in children and adolescents. Some important characteristics of DBD vary based on the presence or absence of comorbid attention-deficit/hyperactivity disorder (ADHD), which may affect the understanding of and treatment decision-making related to the disorders. Thus, identifying neurobiological characteristics of DBD with comorbid ADHD (DBD+ADHD) can provide a basis to establish a better understanding of the condition. This study aimed to assess abnormal white matter microstructural alterations in DBD+ADHD as compared to DBD alone and healthy controls using diffusion tensor imaging (DTI). Thirty-three DBD (19 with comorbid ADHD) and 46 age-matched healthy adolescents were studied using DTI. Fractional anisotropy (FA), and mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) were analyzed using tract-based spatial statistics (TBSS). Significantly lower FA and higher MD, RD and AD in many white matter fibers were found in adolescents with DBD+ADHD compared to controls. Moreover, lower FA and higher RD were also found in the DBD+ADHD versus the DBD alone group. Alterations of white matter integrity found in DBD patients were primarily associated with ADHD, suggesting that ADHD comorbidity in DBD is reflected in greater abnormality of microstructural connections.
authors: Department of Radiology and Imaging Sciences, IU Center for Neuroimaging, Indianapolis, IN, USA. ywang1@iupui.edu
authors: Yang
authors: Y
authors: Wang
authors: Kelly K
authors: KK
authors: Horst
authors: William G
authors: WG
authors: Kronenberger
authors: Tom A
authors: TA
authors: Hummer
authors: Kristine M
authors: KM
authors: Mosier
authors: Andrew J
authors: AJ
authors: Kalnin
authors: David W
authors: DW
authors: Dunn
authors: Vincent P
authors: VP
authors: Mathews
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000473:pathology*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000150:complications* / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009434:Neural Pathways / Q000473:pathology