title: Does endoscopic treatment for early oesophageal cancers give equivalent oncological outcomes as compared with oesophagectomy? Best evidence topic (BET).
abstract: A best evidence topic was written according to a structured protocol. The question addressed was whether endoscopic mucosal resection (EMR) for early oesophageal cancer gives equivalent oncological outcomes as compared to oesophagectomy. A total of 340 papers were found using the reported searches of which 7 represented the best evidence to answer the clinical question. The authors, date, journal, study type, population, main outcome measures and results are tabulated. Oesophagectomy with lymph node dissection for early oesophageal cancer is the standard to which every other treatment modality is compared to. However, the associated mortality and morbidity rates highlight the need for the development of effective, less invasive procedures. The evidence from the present review supports the use of EMR in this context as a first line treatment in T1a (mucosal) oesophageal cancer. The trade-off is a higher recurrence rate which can be dealt with successfully using a tight follow-up schedule and retreatment. The higher rates of lymph node involvement in T1b (submucosal) cancers preclude the use of endoscopic treatment in this setting except for patients unfit for surgery.
authors: Department of Gastroenterology, Hammersmith Hospital, Imperial College London, United Kingdom.
authors: Athanasios
authors: A
authors: Fovos
authors: Omar
authors: O
authors: Jarral
authors: Nikos
authors: N
authors: Panagiotopoulos
authors: Thrasyvoulos
authors: T
authors: Podas
authors: Sameh
authors: S
authors: Mikhail
authors: Emmanouil
authors: E
authors: Zacharakis
mesh_terms: D000368:Aged; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000592:standards; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods* / Q000592:standards; D004947:Esophagus / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome