title: Life satisfaction in young adults 10 or more years after hematopoietic stem cell transplantation for childhood malignant and nonmalignant diseases does not show significant impairment compared with healthy controls: a case-matched study.
abstract: Patients undergoing hematopoietic stem cell transplantation (HSCT) may experience physical and psychological deterioration that impairs their life satisfaction (LS). This study focused on LS in long-term survivors at 10 or more years after HSCT. Fifty-five patients (39 males, median age 25 years) undergoing allogeneic HSCT for childhood malignant (n = 52) or nonmalignant diseases (n = 3) were enrolled. A control group of 98 young adults (59 males, median age 24 years) was considered. A questionnaire with a modified Satisfaction Life Domain Scale was administered. We assessed such domains as education, employment, leisure time, social relationships, and perception of physical status with a 30-item questionnaire. To investigate the association between the domains and the probability of diminished LS, we performed a logistical procedure using the maximum likelihood method. Predictive factors of LS were adjusted for sociodemographic variables. In the multivariate analysis, the participant's level of LS was not significantly correlated with sociodemographic factors or with HSCT status. The same analysis showed a slight trend in favor of the control group (P = .06) for body perception. Our data suggest that the patients who undergo HSCT in childhood have no significant difference in long-term LS compared with healthy controls.
authors: Pediatric Department and Bone Marrow Transplant Unit, S. Gerardo Hospital-Monza, University of Milan Bicocca, Italy. c.uderzo@hsgerardo.org
authors: Cornelio
authors: C
authors: Uderzo
authors: Paola
authors: P
authors: Corti
authors: Marco
authors: M
authors: Pappalettera
authors: Valentina
authors: V
authors: Baldini
authors: Giovanna
authors: G
authors: Lucchini
authors: Dario
authors: D
authors: Meani
authors: Attilio
authors: A
authors: Rovelli
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004522:Educational Status; D004651:Employment; D005260:Female; D019337:Hematologic Neoplasms / Q000523:psychology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D007899:Leisure Activities; D008297:Male; D015999:Multivariate Analysis; D010549:Personal Satisfaction; D010809:Physical Fitness; D012929:Psychological Distance; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D017741:Survivors; D014184:Transplantation, Homologous