title: Influence of a collagen membrane and recombinant platelet-derived growth factor on vertical bone augmentation in implant-fixed deproteinized bovine bone--animal pilot study.
abstract: OBJECTIVE
  Combinations of bone substitute block materials with membrane techniques as well as with growth factors are possible options to enhance the prognosis of vertical bone augmentation. Therefore, the aim of the pilot study was to compare the influence of a collagen membrane and a signal protein (rhPDGF-BB) on vertical bone augmentation with a stable fixed block material (deproteinized bovine bone [DBB]).
  
  
  METHODS
  In 12 rabbits, a DBB-block was implant-fixed on the tibia in a split-leg-design. Included were: DBB only (control), DBB + collagen membrane (test), DBB + rhPDGF-BB (test) and DBB + rhPDGF-BB + collagen membrane (test). 24 samples were examined after 3 (n = 12) and 6 weeks (n = 12). Calculated parameters were new bone area (NBA;%), new vertical bone height (VBH; mm). Due to the pilot character of this study, single values are shown descriptively only.
  
  
  RESULTS
  After 3 weeks, there were constant higher NBA values in the rhPDGF-BB-group without membrane (NBA (%) DBB: 30/16/4; DBB + membrane: 25/17/7, DBB + rhPDGF-BB: 40/33/34, DBB + rhPDGF-BB + membrane: 0/30/16; VBH (mm) DBB: 1.2/1.2/1, DBB + membrane: 0.7/0.9/1, DBB + rhPDGF-BB: 0.7/0.9/1, DBB + rhPDGF-BB + membrane: 0/1.1/1). After 6 weeks, both membrane groups showed a constant higher NBA and VBH independent to the use of rhPDGF-BB (NBA DBB: 3/0/5, DBB + membrane: 20/35/31, DBB + rhPDGF-BB: 5/8/4, DBB + rhPDGF-BB + membrane: 31/35/40; VBH DBB: 0.3/0.3/0.6, DBB + membrane: 1.6/2.4/2.1, DBB + rhPDGF-BB: 0.4/0.7/0.8, DBB + rhPDGF-BB + membrane: 1.8/2/1.8).
  
  
  CONCLUSIONS
  For vertical augmentation, the addition of rhPDGF-BB to DBB-blocks may increase early bone growth. In the later phase, the use of a collagen membrane enhances new bone volume and height to a significant greater extend. Even if the results are higher than those in the non-membrane groups, the low gain of bone after the short time periods still needs improvement.
authors: Department of Oral, Maxillofacial and Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.
authors: P W
authors: PW
authors: Kämmerer
authors: V
authors: V
authors: Palarie
authors: E
authors: E
authors: Schiegnitz
authors: V
authors: V
authors: Nacu
authors: F G
authors: FG
authors: Draenert
authors: B
authors: B
authors: Al-Nawas
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D000077214:Becaplermin; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000494:pharmacology*; D002417:Cattle; D003094:Collagen / Q000494:pharmacology*; D015921:Dental Implants; D010865:Pilot Projects; D011446:Prospective Studies; D020574:Proto-Oncogene Proteins c-sis / Q000494:pharmacology*; D011817:Rabbits
chemical_list: C106416:Bio-Gide; D018786:Bone Substitutes; D015921:Dental Implants; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D003094:Collagen