title: Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus.
abstract: BACKGROUND
  Marmosets are susceptible to dengue virus (DENV) infection. However, blood parameter data and clinical signs of DENV-infected marmosets are limited.
  
  
  METHODS
  Blood hematological and serum biochemical values were obtained from twelve DENV-inoculated and four mock-infected marmosets. Additionally, body temperature and activity level were determined.
  
  
  RESULTS
  Five DENV-inoculated marmosets demonstrated thrombocytopenia, nine demonstrated leucopenia, and five demonstrated an increase in the levels of AST, ALT, LDH, and BUN. Additionally, seven DENV-inoculated marmosets demonstrated clinical signs including fever and decreases in activity. None of the four mock-inoculated marmosets demonstrated changes in either hematological or biochemical parameters.
  
  
  CONCLUSIONS
  Marmosets inoculated with DENV exhibited clinical signs and changes in hematological and biochemical parameters. The results suggest that blood parameter data and clinical signs could potentially be useful markers for understanding the progress of DENV infection in studies using marmosets.
authors: Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
authors: Tsutomu
authors: T
authors: Omatsu
authors: Meng Ling
authors: ML
authors: Moi
authors: Tomohiko
authors: T
authors: Takasaki
authors: Shinichiro
authors: S
authors: Nakamura
authors: Yuko
authors: Y
authors: Katakai
authors: Shigeru
authors: S
authors: Tajima
authors: Mikako
authors: M
authors: Ito
authors: Tomoyuki
authors: T
authors: Yoshida
authors: Akatsuki
authors: A
authors: Saito
authors: Hirofumi
authors: H
authors: Akari
authors: Ichiro
authors: I
authors: Kurane
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D002144:Callithrix / Q000821:virology; D003715:Dengue / Q000097:blood* / Q000821:virology; D003716:Dengue Virus; D004195:Disease Models, Animal; D008297:Male