title: [Allergic transfusion reactions in a patient with multiple food allergies].
abstract: METHODS
  A 13-year-old girl with an osteosarcoma was treated by surgery and chemotherapy. During three transfusions of apheresis platelet concentrates allergic reactions occurred, partly in spite of premedication with an antihistamine and a corticoid.
  
  
  METHODS
  As the patient declared to be allergic to some foods, in-vitro tests for allergen-specific IgE antibodies were performed and showed markedly positive results for specific IgE to carrot and celery, less so to hazelnut, peanut and a lot of other food antigens. The donor of one of the unsuitable platelet concentrates remembered when questioned, that he had eaten carrots and chocolate with hazelnuts during the evening before platelet donation.
  
  
  METHODS
  Two washed platelet concentrates were transfused without any problem. Furthermore, transfusions of nine red blood cell concentrates and one unit of virus-inactivated frozen pooled plasma were well tolerated.
  
  
  CONCLUSIONS
  Patients should be asked for allergies previous to transfusions to be alert to allergic reactions in patients with a positive history of food or drug allergies. If premedication with antihistamines does not prevent severe allergic transfusion reactions, transfusion of washed platelet concentrates and of virus-inactivated frozen pooled plasma can be considered.
authors: Department Medizinische Mikrobiologie und Krankenhaushygiene, Medizet, Städtisches Klinikum München GmbH, Deutschland. erwin.strobel@klinikum-muenchen.de
authors: E
authors: E
authors: Strobel
authors: M
authors: M
authors: Schöniger
authors: M
authors: M
authors: Münz
authors: R
authors: R
authors: Hiefinger-Schindlbeck
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D001787:Blood Group Incompatibility / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D001859:Bone Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D012516:Osteosarcoma / Q000628:therapy*; D017713:Platelet Transfusion / Q000009:adverse effects*; D013977:Tibia
chemical_list: D000485:Allergens; D007073:Immunoglobulin E