title: Potent hypoglycemic effect of Nigerian anti-diabetic medicinal plants.
abstract: The objective of this paper was to investigate the phytochemistry and hypoglycemic activities of aqueous extracts of Anisopus mannii, Daniella olivieri, Detarium macrocarpum, Leptedenia hastate and Mimosa invisa, traditionally prescribed for diabetes mellitus. The aqueous extracts were tested for phytochemicals and free radical scavenging activity by the DPPH assay. The antidiabetic tests were performed in normoglycemic and alloxan induced diabetic mice. High intensity of saponins, xanthones, tannins and glycosides were detected in A. mannii, D. macrocarpum and M. invisa, respectively. For the free radical scavenging activity, D. macrocarpum showed the highest activity with an IC50 of 0.027 mg/ml which was 2.1 folds of ascorbic acid. All extracts showed potent hypoglycemic effects in alloxan induced diabetic mice with the highest fasting blood glucose reduction of 70.39 percent in A. mannii which was 1.54 and 0.98 fold of glibenclamide and human insulin, respectively. A. mannii showed the potent hypoglycemic activity which was 1.54 and 0.98 fold of glibenclamide and insulin, respectively. This study confirmed the traditional use of these Nigerian medicinal plants in diabetes treatment. These plants showed high potential for further investigation to novel anti-diabetic drugs.
authors: Chiang Mai University.
authors: Jiradej
authors: J
authors: Manosroi
authors: Moses Z
authors: MZ
authors: Zaruwa
authors: Aranya
authors: A
authors: Manosroi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000378:metabolism; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D016488:Medicine, African Traditional / Q000379:methods*; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D001786:Blood Glucose; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D005905:Glyburide