title: Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients.
abstract: The present study aimed to evaluate the role of genetic polymorphisms in the emergence of lipoatrophy or lipodystrophy in HIV-infected patients with antiretroviral therapy (ART) in Thailand. Position 455 upstream of the Apolipoprotein C3 gene (ApoC3 T-455C, rs2854116), codon 64 of the Beta3 adrenergic receptor gene (ARβ3 Tcod64C, rs4994), and position 670 upstream of the Fas gene (Fas A-670G, rs1800682) were genotyped in 829 HIV-infected Thai patients who had started ART. Crude and adjusted incidence rate ratios (IRR) were calculated using Poisson regression. The serum levels of cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also analyzed. Multivariate analysis revealed an association between the Fas -670AA genotype, but not the ApoC3 -455 or ARβ3 cod64 genotypes, with the incidence of lipoatrophy after adjusting for gender and stavudine (d4T)-containing regimens (IRR=1.72, 95% CI=1.20-2.45, p=0.003). However, ApoC3 -455C homozygous patients showed elevated serum levels of triglycerides, while this genotype did not affect serum total cholesterol, HDL, or LDL levels in patients with lipoatrophy or lipodystrophy. In contrast, the ARβ3 cod64 genotype did not show any significant association with the serum levels of cholesterol, triglycerides, HDL, or LDL. In conclusion, Fas -670AA affected the incidence of lipoatrophy in HIV-1-infected Thai patients, while the ApoC3 -455C allele affected the serum levels of triglycerides. These results confirmed the role of genetics in the development of ART-related metabolic disorders.
authors: Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand. siratlik@gmail.com
authors: Sirirat
authors: S
authors: Likanonsakul
authors: Tippawan
authors: T
authors: Rattanatham
authors: Siriluk
authors: S
authors: Feangvad
authors: Sumonmal
authors: S
authors: Uttayamakul
authors: Wisit
authors: W
authors: Prasithsirikul
authors: Somkid
authors: S
authors: Srisopha
authors: Ravee
authors: R
authors: Nitiyanontakij
authors: Pimrapat
authors: P
authors: Tengtrakulcharoen
authors: Maciej
authors: M
authors: Tarkowski
authors: Agostino
authors: A
authors: Riva
authors: Emi E
authors: EE
authors: Nakayama
authors: Tatsuo
authors: T
authors: Shioda
mesh_terms: D000328:Adult; D053305:Apolipoprotein C-III / Q000235:genetics; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D002784:Cholesterol / Q000097:blood; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005838:Genotype; D015497:HIV-1; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D015994:Incidence; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D013785:Thailand / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D053305:Apolipoprotein C-III; D053222:Fas Ligand Protein; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides; D002784:Cholesterol