title: Tumor-targeting multi-functional nanoparticles for theragnosis: new paradigm for cancer therapy.
abstract: Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
authors: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors: Ju Hee
authors: JH
authors: Ryu
authors: Heebeom
authors: H
authors: Koo
authors: In-Cheol
authors: IC
authors: Sun
authors: Soon Hong
authors: SH
authors: Yuk
authors: Kuiwon
authors: K
authors: Choi
authors: Kwangmeyung
authors: K
authors: Kim
authors: Ick Chan
authors: IC
authors: Kwon
mesh_terms: D000818:Animals; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D010778:Photochemotherapy; D010789:Phototherapy; D034741:RNA, Small Interfering / Q000627:therapeutic use
chemical_list: D034741:RNA, Small Interfering