title: Primary jaw tumors in children.
abstract: OBJECTIVE
  To document tumor type, biological/clinical behavior, management, and outcomes in children with primary jaw tumors.
  
  
  METHODS
  A retrospective analysis of children with primary benign jaw tumors evaluated at Massachusetts General Hospital and Children's Hospital Boston from 1991 to 2009 was conducted. Patients were included if they were aged 16 years or younger and had adequate records and follow-up. Patient charts, radiographs, and pathology reports were reviewed. Demographic data; clinical, radiographic, and histopathologic findings; treatment; and outcomes were recorded. Predictor variables were tumor type, clinical behavior (nonaggressive/aggressive), and treatment. Outcome variables included presence or absence of recurrence and complications. Descriptive statistics were computed.
  
  
  RESULTS
  There were 102 patients (44 male and 58 female patients) with a mean age of 8.3 years (range, 6 months to 16 years). Tumors were grouped by tumor type: mesenchymal (n=96), neurogenic (n=5), vascular (n=5), or hematopoietic (n=3); in addition, when appropriate, they were classified as nonaggressive (n=54) or aggressive (n=27). Treatment was based on the tumor's clinical/biological behavior and radiographic features and whether it was solitary or multifocal. Patients with nonaggressive tumors were treated by enucleation, debulking/contouring, or observation, and the recurrence rate was 0%. Aggressive tumors underwent en bloc resection or enucleation with systemic adjuvant therapy, and the recurrence rate was 7.1%. Mean follow-up was 2.4 years.
  
  
  CONCLUSIONS
  The results of this study indicate that primary jaw tumors in children exhibit variable biological/clinical behavior, often not predicted by descriptive histologic findings. Management of these tumors should therefore be guided by clinical/biological behavior.
authors: Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, and Department of Plastic and Oral Surgery, Children's Hospital Boston, Boston, MA 02445, USA. shelly.abramowicz@childrens.harvard.edu
authors: Shelly
authors: S
authors: Abramowicz
authors: Batya R
authors: BR
authors: Goldwaser
authors: Maria J
authors: MJ
authors: Troulis
authors: Bonnie L
authors: BL
authors: Padwa
authors: Leonard B
authors: LB
authors: Kaban
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D018214:Fibroma, Ossifying / Q000473:pathology* / Q000601:surgery; D005870:Giant Cell Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007573:Jaw Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008648:Mesoderm / Q000473:pathology; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D016896:Treatment Outcome