title: Interaction between tylosin and bentonite clay from a pharmacokinetic perspective.
abstract: The interaction between bentonite and tylosin was investigated in broiler chickens, based on pharmacokinetic characteristics obtained in vivo. Simultaneous oral administration of bentonite and tylosin significantly lowered plasma levels of tylosin and reduced the area under the plasma concentration-time curve (AUC(0-inf)), maximal plasma concentration (C(max)), time to maximal plasma concentration (T(max)) and relative oral bioavailability. The results prove unambiguously the binding of tylosin by bentonite. Simultaneous administration of tylosin (in the drinking water or feed) and bentonite (mixed in the feed as a mycotoxin binder) should therefore be avoided.
authors: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. mathias.devreese@ugent.be
authors: Mathias
authors: M
authors: Devreese
authors: Ann
authors: A
authors: Osselaere
authors: Joline
authors: J
authors: Goossens
authors: Virginie
authors: V
authors: Vandenbroucke
authors: Siegrid
authors: S
authors: De Baere
authors: Patrick
authors: P
authors: De Backer
authors: Siska
authors: S
authors: Croubels
mesh_terms: D000284:Administration, Oral; D000538:Aluminum Silicates / Q000493:pharmacokinetics*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001546:Bentonite / Q000493:pharmacokinetics*; D001682:Biological Availability; D002645:Chickens / Q000502:physiology*; D002853:Chromatography, Liquid / Q000662:veterinary; D000077215:Clay; D004338:Drug Combinations; D004347:Drug Interactions; D053719:Tandem Mass Spectrometry / Q000662:veterinary; D015645:Tylosin / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000538:Aluminum Silicates; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D001546:Bentonite; D000077215:Clay; D015645:Tylosin