title: Preserving the genome by regulating chromatin association with the nuclear envelope.
abstract: The nuclear envelope compartmentalizes chromatin within eukaryotic cells and influences diverse cellular functions by controlling nucleocytoplasmic trafficking. Recent evidence has revealed the importance of interactions between chromatin and nuclear envelope components in the maintenance of genome integrity. Nuclear pore complexes (NPCs), traditionally regarded as transport gateways, have emerged as specialized hubs involved in organizing genome architecture, influencing DNA topology, and modulating DNA repair. Here, we review the interplay between the nuclear envelope, chromatin and DNA damage checkpoint pathways, and discuss the physiological and pathological implications of these associations.
authors: IFOM (Fondazione Istituto FIRC di Oncologia Molecolare) at the IFOM-European Institute of Oncology Campus, Via Adamello 16, 20139 Milan, Italy. rodrigo.bermejo@usal.es
authors: Rodrigo
authors: R
authors: Bermejo
authors: Amit
authors: A
authors: Kumar
authors: Marco
authors: M
authors: Foiani
mesh_terms: D000818:Animals; D001692:Biological Transport; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D016678:Genome; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism*
chemical_list: D002843:Chromatin