title: Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies.
abstract: OBJECTIVE
  To analyse the value of cardiovascular magnetic resonance (CMR)-derived myocardial parameters to differentiate left ventricular non-compaction cardiomyopathy (LVNC) from other cardiomyopathies and controls.
  
  
  METHODS
  We retrospectively analysed 12 patients with LVNC, 11 with dilated and 10 with hypertrophic cardiomyopathy and compared them to 24 controls. LVNC patients had to fulfil standard echocardiographic criteria as well as additional clinical and imaging criteria. Cine steady-state free precession and late gadolinium enhancement (LGE) imaging was performed. The total LV myocardial mass index (LV-MMI), compacted (LV-MMI(compacted)), non-compacted (LV-MMI(non-compacted)), percentage LV-MM(non-compacted), ventricular volumes and function were calculated. Data were compared using analysis of variance and Dunnett's test. Additionally, semi-quantitative segmental analyses of the occurrence of increased trabeculation were performed.
  
  
  RESULTS
  Total LV-MMI(non-compacted) and percentage LV-MM(non-compacted) were discriminators between patients with LVCN, healthy controls and those with other cardiomyopathies with cut-offs of 15 g/m(2) and 25 %, respectively. Furthermore, trabeculation in basal segments and a ratio of non-compacted/compacted myocardium of ≥3:1 were criteria for LVNC. A combination of these criteria provided sensitivities and specificities of up to 100 %. None of the LVNC patients demonstrated LGE.
  
  
  CONCLUSIONS
  Absolute CMR quantification of the LV-MMI(non-compacted) or the percentage LV-MM(non-compacted) and increased trabeculation in basal segments allows one to reliably diagnose LVNC and to differentiate it from other cardiomyopathies.
  
  
  CONCLUSIONS
  Cardiac magnetic resonance imaging can reliably diagnose left ventricular non-compaction cardiomyopathy. Differentiation of LVNC from other cardiomyopathies and normal hearts is possible. The best diagnostic performance can be achieved if combined MRI criteria for the diagnosis are used.
authors: Department of Diagnostic and Interventional Radiology, University of Leipzig - Heart Center, Strümpellstr. 39, 04289, Leipzig, Germany. matthias.grothoff@herzzentrum-leipzig.de
authors: Matthias
authors: M
authors: Grothoff
authors: Milena
authors: M
authors: Pachowsky
authors: Janine
authors: J
authors: Hoffmann
authors: Maximilian
authors: M
authors: Posch
authors: Sabine
authors: S
authors: Klaassen
authors: Lukas
authors: L
authors: Lehmkuhl
authors: Matthias
authors: M
authors: Gutberlet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D009202:Cardiomyopathies / Q000175:diagnosis*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D003287:Contrast Media; D003937:Diagnosis, Differential; D004452:Echocardiography; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA