title: Regulation of GPCR-mediated smooth muscle contraction: implications for asthma and pulmonary hypertension.
abstract: Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca(2+)-mobilization and -sensitization.
authors: Department of Asthma, Allergy, and Lung Biology, King's College, London, United Kingdom.
authors: D B
authors: DB
authors: Wright
authors: S
authors: S
authors: Tripathi
authors: A
authors: A
authors: Sikarwar
authors: K T
authors: KT
authors: Santosh
authors: J
authors: J
authors: Perez-Zoghbi
authors: O O
authors: OO
authors: Ojo
authors: N
authors: N
authors: Irechukwu
authors: J P T
authors: JP
authors: Ward
authors: D
authors: D
authors: Schaafsma
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D002118:Calcium