title: Pulse analysis in bipolar disordered and nonpsychotic human subjects.
abstract: The research literature indicates that patients with bipolar disorder (BPD) differ from healthy individuals in various ways that are also recognized in traditional Chinese medicine. The purpose of the current study was to analyze the pulse spectra in BPD patients to determine any differences from nonpsychotic healthy individuals. Sphygmography was used to measure the radial arterial pulse waves in all subjects. We analyzed the original waveforms and then transformed them into frequency spectra via Fourier transformation. The relative strength of each harmonic, believed to be connected to meridians in Chinese medicine, was identified from the frequency, and we compared the differences among the harmonics. A total of sixty individuals, thirty with BPD and thirty nonpsychotic healthy controls, participated in the study. The harmonic values of C4 (Lung Meridian) on the right hand, 401.33 ± 50.10 vs. 762.44 ± 125.17, were significantly different (p < 0.05) between the BPD group and the nonpsychotic healthy group. The harmonic percentage of C3 (Spleen Meridian) on the right hand, 7.85 ± 0.59% vs. 10.79 ± 1.01%, and C4 (Lung Meridian), 1.80 ± 0.15 vs. 3.24 ± 0.43, was significantly different (p < 0.05) between the two groups. The results were similar for the right and left hands. In this study, we objectively detected constitutional differences between BPD patients and healthy controls through arterial pulse analysis. The pulse spectrum analyzer is a non-invasive diagnostic tool that can be used to integrate scientific technology with traditional Chinese medicine. We plan further study in this field to improve the accuracy of diagnosis in Chinese medicine.
authors: Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. fjchen@mail.cmu.edu.tw
authors: Fun-Jou
authors: FJ
authors: Chen
authors: Hong-Song
authors: HS
authors: Wang
authors: Chih-Yang
authors: CY
authors: Huang
authors: Yueh-Sheng
authors: YS
authors: Chen
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis*; D001794:Blood Pressure / Q000502:physiology; D001824:Body Constitution; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D005583:Fourier Analysis; D006225:Hand; D006339:Heart Rate; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D016740:Meridians; D008875:Middle Aged; D011674:Pulse; D017534:Radial Artery / Q000502:physiology; D012016:Reference Values