title: Patterns of fractional amplitude of low-frequency oscillations in occipito-striato-thalamic regions of first-episode drug-naïve panic disorder.
abstract: OBJECTIVE
  This study was designed to investigate patterns of fractional amplitude of low-frequency fluctuations (fALFF, an indicator for the intensity of regional brain spontaneous activities) of patients with first-episode drug-naïve panic disorder (PD).
  
  
  METHODS
  Thirty patients (17 females, 13 males, age: 47.70±10.69 years old) and twenty healthy controls (10 females, 10 males, age: 41.40±13.94 years old) received 3-Tesla resting-state functional magnetic resonance imaging (RFMRI) scanning and the rating of clinical scales. RFMRI data was processed and analyzed by the REST toolbox (resting-state functional MRI data analysis toolbox) to calculate fALFF. fALFF were compared between patients and controls to detect endophenotype of fALFF in patients with first-episode drug-naïve PD.
  
  
  RESULTS
  We found decreased fALFF in right middle occipital gyrus [FDR (false discovery rate) corrected p<0.05, cluster >5 voxles, volume >135mm(3), T threshold: 6.1168, surface connected theory] and increased fALFF in right putamen and right ventral lateral nucleus of thalamus of patients (uncorrected p<0.00005, cluster >5 voxles, volume >135mm(3), T threshold: 4.5439, surface connected theory). fALFF of patients also showed a positive correlation with clinical rating scores of PD in right cuneus.
  
  
  CONCLUSIONS
  Occipito-striato-thalamic dysfunction of fALFF might represent a kind of endophenotype biomarker of first-episode drug-naïve PD.
authors: Division of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC. stephenlai99@gmail.com
authors: Chien-Han
authors: CH
authors: Lai
authors: Yu-Te
authors: YT
authors: Wu
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D003342:Corpus Striatum / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000503:physiopathology*; D016584:Panic Disorder / Q000453:epidemiology / Q000503:physiopathology*; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology*