title: Neural basis of recollection in first-episode major depression.
abstract: BACKGROUND
  Patients with major depressive disorder (MDD) display impairments in recollection, which have been explained by both hippocampal and prefrontal dysfunction. Here, we used an event-related fMRI design, to dissociate hippocampal and prefrontal contributions to the neural processes involved in recollection success and recollection attempt early in the course of MDD.
  
  
  METHODS
  To disentangle state- and trait-effects of depression, we included 20 medication-naive patients with a first depressive episode, 20 medication-free patients recovered from a first episode, and 20 matched, healthy controls in an event-related fMRI study using a source recollection paradigm.
  
  
  RESULTS
  Group comparisons revealed that during the acute state of depression there is an increase in left prefrontal activity related to recollection attempt, while there were no differences in neural correlates of successful recollection.
  
  
  CONCLUSIONS
  Our results indicate that in the early course of depression, depressive state is associated with increased left prefrontal activation during the attempt to recollect source information suggesting an increased need for executive control during recollection in MDD. In this sample of first-episode MDD patients we found no evidence for hippocampal dysfunction.
authors: Department of Psychiatry, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands. P.vanEijndhoven@psy.umcn.nl
authors: Philip
authors: P
authors: van Eijndhoven
authors: Guido
authors: G
authors: van Wingen
authors: Guillén
authors: G
authors: Fernández
authors: Mark
authors: M
authors: Rijpkema
authors: Monica
authors: M
authors: Pop-Purceleanu
authors: Robbert Jan
authors: RJ
authors: Verkes
authors: Jan
authors: J
authors: Buitelaar
authors: Indira
authors: I
authors: Tendolkar
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000523:psychology; D001288:Attention / Q000502:physiology; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D056344:Executive Function / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult