title: GTfold: enabling parallel RNA secondary structure prediction on multi-core desktops.
abstract: BACKGROUND
  Accurate and efficient RNA secondary structure prediction remains an important open problem in computational molecular biology. Historically, advances in computing technology have enabled faster and more accurate RNA secondary structure predictions. Previous parallelized prediction programs achieved significant improvements in runtime, but their implementations were not portable from niche high-performance computers or easily accessible to most RNA researchers. With the increasing prevalence of multi-core desktop machines, a new parallel prediction program is needed to take full advantage of today's computing technology.
  
  
  RESULTS
  We present here the first implementation of RNA secondary structure prediction by thermodynamic optimization for modern multi-core computers. We show that GTfold predicts secondary structure in less time than UNAfold and RNAfold, without sacrificing accuracy, on machines with four or more cores.
  
  
  CONCLUSIONS
  GTfold supports advances in RNA structural biology by reducing the timescales for secondary structure prediction. The difference will be particularly valuable to researchers working with lengthy RNA sequences, such as RNA viral genomes.
authors: School of Mathematics, Georgia Institute of Technology, Atlanta, GA, USA.
authors: M Shel
authors: MS
authors: Swenson
authors: Joshua
authors: J
authors: Anderson
authors: Andrew
authors: A
authors: Ash
authors: Prashant
authors: P
authors: Gaurav
authors: Zsuzsanna
authors: Z
authors: Sükösd
authors: David A
authors: DA
authors: Bader
authors: Stephen C
authors: SC
authors: Harvey
authors: Christine E
authors: CE
authors: Heitsch
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000295:instrumentation / Q000379:methods*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D017423:Sequence Analysis, RNA; D012984:Software; D013816:Thermodynamics
chemical_list: D012313:RNA