title: Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma.
abstract: Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.
authors: Department of Head and Neck Surgery, Zhejiang Cancer Hospital, China.
authors: Chao
authors: C
authors: Chen
authors: Miriam
authors: M
authors: Zimmermann
authors: Inge
authors: I
authors: Tinhofer
authors: Andreas M
authors: AM
authors: Kaufmann
authors: Andreas E
authors: AE
authors: Albers
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D034622:RNA Interference
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs