title: Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear.
abstract: CONCLUSIONS
  It is suggested that aquaporins (AQPs) 1, 2, and 3, and vasopressin type 2 receptors (V2Rs) in the fluid transporting cells, such as stria vascularis, vestibular dark and transitional cells, and endolymphatic sac epithelial cells, have an important role in fluid transport in the inner ear, while those in the sensory and ganglion cells may play a functional role in the sensory cell transduction system.
  
  
  OBJECTIVE
  To analyze expression of AQP1, AQP2, and AQP3 as well as V2Rs in the normal mouse inner ear.
  
  
  METHODS
  CBA/J mice were used in this study. Localization of AQP1, AQP2, AQP3, and V2Rs in the inner ear, i.e. cochlea, vestibular end organs, and endolymphatic sac, was investigated by immunohistochemistry.
  
  
  RESULTS
  The results show that AQP1, AQP2, AQP3, and V2Rs are abundantly distributed in many inner ear structures, i.e. stria vascularis, inner and outer hair cells, spiral ganglion cells, vestibular sensory and ganglion cells, vestibular dark and transitional cells, and the endolymphatic sac.
authors: Department of Otolaryngology, Hiroshima University Hospital, Japan. masati@hiroshima-u.ac.jp
authors: Masaya
authors: M
authors: Takumida
authors: Akinobu
authors: A
authors: Kakigi
authors: Naoya
authors: N
authors: Egami
authors: Rie
authors: R
authors: Nishioka
authors: Matti
authors: M
authors: Anniko
mesh_terms: D000818:Animals; D051398:Aquaporin 1 / Q000096:biosynthesis*; D051399:Aquaporin 2 / Q000096:biosynthesis*; D051400:Aquaporin 3 / Q000096:biosynthesis*; D001692:Biological Transport / Q000502:physiology*; D003051:Cochlea / Q000378:metabolism / Q000648:ultrastructure; D007758:Ear, Inner / Q000378:metabolism* / Q000648:ultrastructure; D004712:Endolymphatic Sac / Q000378:metabolism / Q000648:ultrastructure; D007150:Immunohistochemistry; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D017483:Receptors, Vasopressin / Q000096:biosynthesis*; D015398:Signal Transduction; D013136:Spiral Ganglion / Q000378:metabolism / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D051399:Aquaporin 2; D017483:Receptors, Vasopressin; D051398:Aquaporin 1; D051400:Aquaporin 3