title: Functional regulation of monocyte-derived dendritic cells by microRNAs.
abstract: Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area.
authors: The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia. zhan@wehi.edu.au
authors: Yifan
authors: Y
authors: Zhan
authors: Li
authors: L
authors: Wu
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000235:genetics; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D034622:RNA Interference
chemical_list: D016207:Cytokines; D035683:MicroRNAs