title: Combined surgical resection and radiofrequency ablation as treatment for metastatic ocular melanoma.
abstract: OBJECTIVE
  Ocular melanoma is a rare disease with a strong predilection for the liver. Systemic and locoregional treatments for metastatic ocular melanoma have had disappointing results, with an average survival of 5-7 months. Resection and/or radiofrequency ablation (RFA) of liver lesions were attempted to improve the patient outcomes.
  
  
  METHODS
  Eight patients with liver metastasis from ocular melanoma underwent surgery and/or RFA at the University of Southern California, University Hospital from 1 January 2001 to 31 December 2009. Their charts were retrospectively reviewed.
  
  
  RESULTS
  All patients had undergone eye enucleation as the primary treatment. Four patients had all metastatic liver lesions addressed: one patient underwent left lateral segmentectomy and three patients had combinations of left lateral segmentectomies, wedge resections and RFA of two to four lesions. Two patients underwent surgical biopsies for diagnosis, one patient was unresectable and one patient underwent RFA of a dominant lesion. The median survival was 36 months. The median survival of patients who underwent surgery alone or in conjunction with RFA to address all liver lesions was 46 months.
  
  
  CONCLUSIONS
  There are few reports of RFA for metastatic ocular melanoma. RFA of liver lesions in addition to resection can perhaps lead to improved survival and may play a critical role in the future management of this disease.
authors: Division of Hepatobiliary/Pancreatic Surgery and Abdominal Transplantation, Keck School of Medicine, University of Southern California, 1500 San Pablo, Suite 400, Los Angeles, CA 90033, USA.
authors: Elika
authors: E
authors: Derek
authors: Lea
authors: L
authors: Matsuoka
authors: Sophoclis
authors: S
authors: Alexopoulos
authors: Alexander
authors: A
authors: Fedenko
authors: Yuri
authors: Y
authors: Genyk
authors: Rick
authors: R
authors: Selby
mesh_terms: D000368:Aged; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D005134:Eye Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome