title: The spread of carbapenem-resistant Enterobacteriaceae in South Africa: risk factors for acquisition and prevention.
abstract: New, effective antibiotics are only likely to become available in 15 - 20 years. To prevent deaths from untreatable Gram-negative infections in South Africa, the rights of any doctor, whether in general or in hospital practice, to indiscriminately prescribe whatever antibiotic they wish, and in whatever fashion, must be challenged. Furthermore, although prevention of the emergence and subsequent spread of carbapenem-resistant Enterobacteriaceae (CRE) has focused on acute and chronic care facilities and inter alia on antibiotic exposure in these institutions, CRE may soon become an issue within entire communities, highlighting a role for public health authorities in CRE prevention efforts.
authors: Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa. brinka@ampath.co.za
authors: Adrian
authors: A
authors: Brink
authors: Jennifer
authors: J
authors: Coetzee
authors: Cornelis
authors: C
authors: Clay
authors: Craig
authors: C
authors: Corcoran
authors: Johan
authors: J
authors: van Greune
authors: J D
authors: JD
authors: Deetlefs
authors: Louise
authors: L
authors: Nutt
authors: Charles
authors: C
authors: Feldman
authors: Guy
authors: G
authors: Richards
authors: Patrice
authors: P
authors: Nordmann
authors: Laurent
authors: L
authors: Poirel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D017053:Infection Control / Q000379:methods*; D011159:Population Surveillance; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems