title: The expression of interleukin (IL)-6, IL-8, and their receptors in fallopian tubes with ectopic tubal gestation.
abstract: OBJECTIVE
  To investigate the level of expression of the cytokines interleukin (IL) -8 and IL-6 and their receptors in fallopian tubes with tubal ectopic gestation.
  
  
  METHODS
  Immunohistochemistry (IHC) was used to study the expression of IL-8, CXCR1, CXCR2, IL-6, and IL-6 receptor alpha in fallopian tubes with tubal ectopic gestation in comparison with normal fallopian tubes.
  
  
  METHODS
  Hospital.
  
  
  METHODS
  We studied fallopian tubes from 50 patients with tubal ectopic gestation and normal fallopian tubes from 25 patients who had hysterectomy and bilateral salpingo-oopherectomy for uterine or ovarian lesions.
  
  
  METHODS
  The expression of the chemokines/cytokines and their receptors was evaluated by IHC.
  
  
  METHODS
  Level of expression and tissue distribution of the different antigens.
  
  
  RESULTS
  IHC results showed that the expression levels of IL-6 and IL-8, as well as CXCR1, were significantly up-regulated, particularly near the implantation site in fallopian tubes with tubal gestation, while the expression levels of CXCR2 and IL-6Rα were not changed in comparison with normal fallopian tubes.
  
  
  CONCLUSIONS
  The results suggest a role for IL-6, IL-8, and CXCR1 in the pathophysiology of tubal ectopic gestation.
authors: Imperial College, London, United Kingdom.
authors: Erin S
authors: ES
authors: Balasubramaniam
authors: Susan
authors: S
authors: Van Noorden
authors: Mona
authors: M
authors: El-Bahrawy
mesh_terms: D005187:Fallopian Tubes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D023062:Receptors, Interleukin-8A / Q000378:metabolism*; D023063:Receptors, Interleukin-8B / Q000378:metabolism*; D012307:Risk Factors
chemical_list: C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D019947:Receptors, Interleukin-6; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; C113250:interleukin-6 receptor alpha