title: Differences in oligoclonal bands and visual evoked potentials in patients with radiologically and clinically isolated syndrome.
abstract: The aim of this study was to determine the prevalence of cerebrospinal fluid (CSF) and visual evoked potentials (VEP) abnormalities, and ANA titers in patients with either clinically or radiologically isolated syndrome (CIS and RIS). We gathered records from 330 hospitalized patients diagnosed with CIS/RIS within a 3-year period. Symptoms, CSF findings, VEP and ANA titers were analyzed. Incomplete transverse myelitis was the presenting symptom in 32.7 %, optic neuritis in 22.7 %, brainstem/cerebellar symptoms in 19.4 %, hemispheral symptoms in 2.7 % and multifocal symptoms in 15.2 % of patients in the CIS cohort. We identified 24 (7.3 %) patients with atypical or no symptoms-RIS cohort. Positive oligoclonal bands (OCB) were found in 75.5 % patients. When we divided the patients into CIS and RIS groups, the presence of OCB was 82.4 and 44 %, respectively. VEP were performed in 87.3 % patients and prolonged latencies were found in 39.6 % of them (43.8 and 14.3 % in the CIS and RIS cohort, respectively). ANA were positive in 15.2 % (14.7 and 16 % in the CIS and RIS cohort, respectively) of patients. RIS patients had statistically significant lower percentages of positive OCB and positive VEP (P = 0.002 and 0.001, respectively). Detection of OCB and VEP still has an important role for satisfying the "no better explanation for the clinical presentation" criteria when presented with a patient with a first "radiological" demyelinating episode.
authors: Department of Neurology, Referral Center for Demyelinating Diseases of the Central Nervous System, University Hospital Center Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia.
authors: Tereza
authors: T
authors: Gabelić
authors: Marin
authors: M
authors: Radmilović
authors: Vanja
authors: V
authors: Posavec
authors: Ana
authors: A
authors: Skvorc
authors: Mateja
authors: M
authors: Bošković
authors: Ivan
authors: I
authors: Adamec
authors: Iva
authors: I
authors: Milivojević
authors: Barbara
authors: B
authors: Barun
authors: Mario
authors: M
authors: Habek
mesh_terms: D000293:Adolescent; D000328:Adult; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000503:physiopathology; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D009460:Neurologic Examination; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid*
chemical_list: D043025:Oligoclonal Bands