title: Hypomagnesemia as a risk factor for the non-recovery of the renal function in critically ill patients with acute kidney injury.
abstract: BACKGROUND
  The aim of this study was to evaluate the role of hypomagnesemia as a risk factor for the development of acute kidney injury (AKI) and non-recovery of renal function in critically ill patients.
  
  
  METHODS
  A cohort study was conducted by collecting data from March to June 2011 in 232 patients who were admitted into an intensive care unit (ICU). Magnesium serum levels were measured daily during ICU stay. Hypomagnesemia was defined as an episode of serum magnesium concentration of <0.70 mmol/L during ICU stay. The Risk, Injury, Failure, Loss and End-stage kidney disease (RIFLE) criteria were used to define AKI. Renal function recovery was defined as an absence of AKI by the RIFLE criteria over a 48-h period, or at ICU discharge, in the patients who developed AKI during ICU stay.
  
  
  RESULTS
  The presence of hypomagnesemia was similar in patients with or without AKI (47 and 62%, respectively, P = 0.36). The presence of hypomagnesemia was higher in patients who did not recover renal function when compared with patients who recovered renal function (70 versus 31%, P = 0.003). A multivariate analysis identified hypomagnesemia as an independent risk factor for non-recovery of renal function (P = 0.005). Patients with and without hypomagnesemia had similar mortality rates (P = 0.63).
  
  
  CONCLUSIONS
  Hypomagnesemia was an independent risk factor for non-recovery of renal function in a cohort of critically ill AKI patients.
authors: Laboratório de Fisiopatologia Experimental, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
authors: Sarah Cascaes
authors: SC
authors: Alves
authors: Cristiane Damiani
authors: CD
authors: Tomasi
authors: Larissa
authors: L
authors: Constantino
authors: Vinícius
authors: V
authors: Giombelli
authors: Roberta
authors: R
authors: Candal
authors: Maria de Lourdes
authors: Mde L
authors: Bristot
authors: Maria Fernanda
authors: MF
authors: Topanotti
authors: Emmanuel A
authors: EA
authors: Burdmann
authors: Felipe
authors: F
authors: Dal-Pizzol
authors: Cassiana Mazon
authors: CM
authors: Fraga
authors: Cristiane
authors: C
authors: Ritter
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008274:Magnesium / Q000097:blood*; D008275:Magnesium Deficiency / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D008274:Magnesium