title: Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia.
abstract: BACKGROUND
  Staphylococcus aureus is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to S.aureus infection is largely mediated by the innate immune system. γδ T cells play an important role in innate immunity to many infectious diseases. However, less is known about the role of these cells during S.aureus-induced pneumonia. In this study, we examined the response and the role of γδ T cells to pulmonary S.aureus infection.
  
  
  RESULTS
  Mice infected with S. aureus intranasally showed rapid γδ T cells accumulation in the lung. Deficiency of γδ T cells led to attenuated bacterial clearance and less tissue damage in lung compared with WT mice. Moreover, TCR-δ-/- mice exhibited impaired neutrophil recruitment and reduced cytokine production at the site of infection. The γδ T cells in response to pulmonary S. aureus infection mainly secreted IL-17 and γδ T cells deficiency reduced IL-17 production, which might regulate the production of neutrophil-inducing cytokine/chemokine in the S. aureus-infected lungs.
  
  
  CONCLUSIONS
  Accumulation of γδ T cells in the lungs to S. aureus infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection.
authors: Department of Clinical Microbiology and Immunology, Faculty of Medical Laboratory Science, Third Military Medical University and National Engineering Technological Research Center of Immunological Biologicals, Chongqing 400038, China.
authors: Ping
authors: P
authors: Cheng
authors: Tao
authors: T
authors: Liu
authors: Wei-Ying
authors: WY
authors: Zhou
authors: Yuan
authors: Y
authors: Zhuang
authors: Liu-sheng
authors: LS
authors: Peng
authors: Jin-Yu
authors: JY
authors: Zhang
authors: Zhi-Nan
authors: ZN
authors: Yin
authors: Xu-hu
authors: XH
authors: Mao
authors: Gang
authors: G
authors: Guo
authors: Yun
authors: Y
authors: Shi
authors: Quan-ming
authors: QM
authors: Zou
mesh_terms: D000818:Animals; D058491:Bacterial Load / Q000276:immunology; D005260:Female; D054884:Host-Pathogen Interactions / Q000276:immunology*; D020381:Interleukin-17 / Q000096:biosynthesis; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration / Q000276:immunology; D011023:Pneumonia, Staphylococcal / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta