title: DNA copy number aberrations associated with lymphovascular invasion in upper urinary tract urothelial carcinoma.
abstract: Recent studies have reported that lymphovascular invasion (LVI) is a predictor of patient prognosis in upper urinary tract urothelial carcinoma (UUTUC). DNA copy number aberrations (DCNAs) identified by array-based comparative genomic hybridization (aCGH) had not previously been examined in UUTUC. We therefore examined DCNAs in UUTUC and compared them with DCNAs in LVI. We applied aCGH technology using DNA chips spotted with 4,030 BAC clones to 32 UUTUC patients. Frequent copy number gains were detected on chromosomal regions 8p23.1 and 20q13.12, whereas frequent copy number losses were detected on chromosomal regions 13q21.1, 17p13.1, 6q16.3, and 17p11.2. DCNAs occurred more frequently in tumors with LVI than in those without it (P = 0.0002), and this parameter was more closely associated with LVI than with the tumor grade or pT stage. Disease-specific survival rate was higher in tumors without LVI than in those with it (P = 0.0120); however, tumor grade and stage were not significant prognostic factors of patient outcome. These data support our hypothesis that tumors with LVI have more genetic alterations in terms of total numbers of DCNAs than those without, and provide proof that aggressive adjuvant therapy should be considered for UUTUC patients with LVI.
authors: Department of Urology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
authors: Taku
authors: T
authors: Misumi
authors: Yoshiaki
authors: Y
authors: Yamamoto
authors: Yoshihiro
authors: Y
authors: Miyachika
authors: Satoshi
authors: S
authors: Eguchi
authors: Yasuyo
authors: Y
authors: Chochi
authors: Motonao
authors: M
authors: Nakao
authors: Kazuhiro
authors: K
authors: Nagao
authors: Takahiko
authors: T
authors: Hara
authors: Shigeru
authors: S
authors: Sakano
authors: Tomoko
authors: T
authors: Furuya
authors: Atsunori
authors: A
authors: Oga
authors: Shigeto
authors: S
authors: Kawauchi
authors: Kohsuke
authors: K
authors: Sasaki
authors: Hideyasu
authors: H
authors: Matsuyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics; D011379:Prognosis; D014571:Urologic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor