title: Full-face rejuvenation using a range of hyaluronic acid fillers: efficacy, safety, and patient satisfaction over 6 months.
abstract: BACKGROUND
  Full-face rejuvenation with dermal fillers in patients with multiple aesthetic indications is rarely studied.
  
  
  OBJECTIVE
  To assess whether a new range of hyaluronic acid filler is suitable for full-face rejuvenation and to evaluate efficacy, safety, and patient satisfaction.
  
  
  METHODS
  In this 6-month study, participants could receive five different fillers from the same range (HA(E) )for up to eight indications (periorbital lines, tear troughs, cheeks, cheek folds, nasolabial folds, upper lip lines, lips, and marionette lines). Outcomes included global aesthetic improvement, improvement in each indication, adverse events, local tolerability, and satisfaction.
  
  
  RESULTS
  Seventy-seven participants with a mean age of 54.5 were enrolled; 48.1% had five or more indications treated. Mean total injection volume (baseline and touch-up) per participant was 6.7 mL. At month 6, 92.1% of participants remained at least improved over baseline, 79.7% of participants were satisfied or very satisfied with the durability of the results, and 63.0% of participants felt a lot or much better than before injection. No specific safety concerns were reported except expected injection site reactions.
  
  
  CONCLUSIONS
  In participants with multiple indications, full-face rejuvenation using HA(E) provided effective, safe, satisfactory results.
authors: Division of Evidence-Based Medicine, Klinik für Dermatologie, Charité-Universitätsmedizin Berlin, Berlin, Germany. berthold.rzany@charite.de
authors: Berthold
authors: B
authors: Rzany
authors: Hugues
authors: H
authors: Cartier
authors: Philippe
authors: P
authors: Kestemont
authors: Patrick
authors: P
authors: Trevidic
authors: Gerhard
authors: G
authors: Sattler
authors: Nabil
authors: N
authors: Kerrouche
authors: Jean-Charles
authors: JC
authors: Dhuin
authors: Y May
authors: YM
authors: Ma
mesh_terms: D000328:Adult; D000368:Aged; D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012060:Rejuvenation
chemical_list: D006820:Hyaluronic Acid