title: Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy.
abstract: Although antiepileptic drugs are often effective in the control of seizures, some patients show little or no improvement. As alternative treatments, different dietary modifications were shown to be beneficial for patients with poor tolerance for AEDS. Previous reports have shown that rice-based oral electrolyte hydration therapy is effective in seizure control in patients with refractory absence seizures. In the present study, using an animal model of absence epilepsy, we showed that the occurrence of spike-and-wave discharges significantly decreases upon switching to electrolyte therapy. We also showed that consumption of solution with the same osmolarity as rice-based oral electrolyte solution leads to a decrease in the number of spike-and-wave discharges per hour. We suggest that the antiepileptic effect of rice-based oral electrolyte hydration therapy can be at least in part due to hyperosmolarity of the ingested solution.
authors: Department of Physiology of Movements, Bogomoletz Institute of Physiology, Kiev, Ukraine.
authors: Arkadij N
authors: AN
authors: Talnov
authors: Elena
authors: E
authors: Isaeva
authors: Alina V
authors: AV
authors: Savotchenko
authors: Galina V
authors: GV
authors: Dovgalets
authors: Juan G
authors: JG
authors: Ochoa
authors: Gregory L
authors: GL
authors: Holmes
authors: Dmytro
authors: D
authors: Isaev
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D058256:Brain Waves / Q000187:drug effects*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004573:Electrolytes / Q000627:therapeutic use*; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar
chemical_list: D000927:Anticonvulsants; D004573:Electrolytes