title: Histologic coagulative tumour necrosis as a prognostic indicator of aggressiveness in renal, lung, thyroid and colorectal carcinomas: A brief review.
abstract: Tumour growth involves two essential deviations from the normal state including the induction of proliferative stimuli, and simultaneous suppression of potentially compensatory cell death. It has been suggested that the development of invasive cancer involves a progressive switch from predominantly apoptotic to necrotic tumour cell death. The presence of tumour necrosis in pathologic specimens may not only reflect tumour biology, but also provide additional beneficial prognostic information. This review emphasises the role of tumour necrosis as an additional prognostic factor for patients with certain types of epithelial neoplasms.
authors: Department of Human Pathology, University of Messina, Messina, Italy.
authors: Rosario
authors: R
authors: Caruso
authors: Antonino
authors: A
authors: Parisi
authors: Anna
authors: A
authors: Bonanno
authors: Domenica
authors: D
authors: Paparo
authors: Emilia
authors: E
authors: Quattrocchi
authors: Giovanni
authors: G
authors: Branca
authors: Marco
authors: M
authors: Scardigno
authors: Francesco
authors: F
authors: Fedele