title: Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.
abstract: The discovery, optimization and structure-activity relationship of novel FATP1 inhibitors have been described. The detailed SAR studies of each moiety of the inhibitors combined with metabolite analysis led to the identification of the potent inhibitors 11p and 11q with improved blood stability.
authors: Lead Discovery & Optimization Research Laboratories I, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan.
authors: Tetsuyoshi
authors: T
authors: Matsufuji
authors: Mika
authors: M
authors: Ikeda
authors: Asuka
authors: A
authors: Naito
authors: Masakazu
authors: M
authors: Hirouchi
authors: Hideo
authors: H
authors: Takakusa
authors: Shoichi
authors: S
authors: Kanda
authors: Masanori
authors: M
authors: Izumi
authors: Jun
authors: J
authors: Harada
authors: Tsuyoshi
authors: T
authors: Shinozuka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D004353:Drug Evaluation, Preclinical; D050612:Fatty Acid Transport Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D001583:Benzoxazoles; D050612:Fatty Acid Transport Proteins; C576465:N-((4-ethyl-5-(((5-(trifluoromethoxy)-1,3-benzoxazol-2-yl)methyl)sulfanyl)-4H-1,2,4-triazol-3-yl)methyl)aniline; D014230:Triazoles