title: T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals.
abstract: Analysis and mathematical modeling of T-lymphocyte perturbation following administration of granulocyte colony stimulating factor (G-CSF) and two large-scale aphereses are reported. 74 HIV-1 positive antiretroviral-treated individuals were infused with gene- or sham-transduced CD34+ hematopoietic stem cells (HSC) in a Phase II clinical trial. T cell numbers were examined in four phases: 1) during steady state; 2) increases in peripheral blood (PB) following G-CSF administration; 3) depletion post-aphereses and 4) reconstitution post HSC infusion. The present analysis provides the first direct estimate of CD4+ T cell distribution and trafficking in HIV-infected individuals on stable HAART, indicating that CD4+ T lymphocytes in PB represent 5.5% of the pool of CD4+ T lymphocytes that traffic to PB.
authors: School of Mathematics and Statistics, University of New South Wales, Sydney 2052, Australia.
authors: Borislav
authors: B
authors: Savkovic
authors: Janet L
authors: JL
authors: Macpherson
authors: John
authors: J
authors: Zaunders
authors: Anthony D
authors: AD
authors: Kelleher
authors: Alison E
authors: AE
authors: Knop
authors: Susan
authors: S
authors: Pond
authors: Louise
authors: L
authors: Evans
authors: Geoff
authors: G
authors: Symonds
authors: John M
authors: JM
authors: Murray
mesh_terms: D001781:Blood Component Removal; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D016923:Cell Death / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D018655:Lymphocyte Count; D008962:Models, Theoretical; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D013997:Time Factors