title: Electric fields generated by synchronized oscillations of microtubules, centrosomes and chromosomes regulate the dynamics of mitosis and meiosis.
abstract: Super-macromolecular complexes play many important roles in eukaryotic cells. Classical structural biological studies focus on their complicated molecular structures, physical interactions and biochemical modifications. Recent advances concerning intracellular electric fields generated by cell organelles and super-macromolecular complexes shed new light on the mechanisms that govern the dynamics of mitosis and meiosis. In this review we synthesize this knowledge to provide an integrated theoretical model of these cellular events. We suggest that the electric fields generated by synchronized oscillation of microtubules, centrosomes, and chromatin fibers facilitate several events during mitosis and meiosis, including centrosome trafficking, chromosome congression in mitosis and synapsis between homologous chromosomes in meiosis. These intracellular electric fields are generated under energy excitation through the synchronized electric oscillations of the dipolar structures of microtubules, centrosomes and chromosomes, three of the super-macromolecular complexes within an animal cell.
authors: State key laboratory of molecular oncology, Cancer Institute & Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College, Room 6107, No,17 Pan Jia Yuan Nan Li, Chao Yang District, Bei Jing, 100021, China. alexanderyz@gmail.com
authors: Yue
authors: Y
authors: Zhao
authors: Qimin
authors: Q
authors: Zhan
mesh_terms: D000818:Animals; D018385:Centrosome / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology*; D055724:Electrophysiological Phenomena / Q000502:physiology*; D008540:Meiosis / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*