title: Effects of a short course of pranlukast combined with systemic corticosteroid on acute asthma exacerbation induced by upper respiratory tract infection.
abstract: BACKGROUND
  Upper respiratory tract infections (URIs) represent the most frequent cause of acute asthma exacerbation. Systemic corticosteroid (CS) is presently recommended for URI-induced asthma exacerbation, although it might inhibit cellular immunity against respiratory virus infection.
  
  
  OBJECTIVE
  To determine the effects of adding a short course (2 weeks) of a leukotriene receptor antagonist (LTRA) to systemic CS on URI-induced acute asthma exacerbation.
  
  
  METHODS
  Twenty-three adult asthmatics (mean age, 42.8 ± 9.8 y; Male:Female, 10:13) with URI-induced acute asthma exacerbation confirmed by a questionnaire and physical findings were randomly assigned to receive either oral prednisolone (PSL) alone or oral PSL plus the LTRA pranlukast (PRL) for 2 weeks (PSL + PRL). The cumulative doses of PSL and the amount of time required to clear asthma-related symptoms were determined. Levels of respiratory syncytial virus (RSV) RNA and influenza viral (IV) antigen in nasopharyngeal swabs were also determined.
  
  
  RESULTS
  Adding PRL significantly reduced the cumulative dose of PSL and tended to reduce the time required to clear asthma-related symptoms. Either RSV or IV was detected in about one-third of the patients.
  
  
  CONCLUSIONS
  The combination of an LTRA and CS might be more useful than CS alone for treating URI-induced acute exacerbation of asthma and reducing the cumulative CS dose.
authors: Second Department of Internal Medicine, University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan. hmatsuse@nagasaki-u.ac.jp
authors: Hiroto
authors: H
authors: Matsuse
authors: Susumu
authors: S
authors: Fukahori
authors: Tomoko
authors: T
authors: Tsuchida
authors: Tetsuya
authors: T
authors: Kawano
authors: Shinya
authors: S
authors: Tomari
authors: Nobuko
authors: N
authors: Matsuo
authors: Tomoya
authors: T
authors: Nishino
authors: Chizu
authors: C
authors: Fukushima
authors: Shigeru
authors: S
authors: Kohno
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D000956:Antigens, Viral / Q000032:analysis; D001249:Asthma / Q000188:drug therapy* / Q000821:virology; D002867:Chromones / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000821:virology; D011239:Prednisolone / Q000008:administration & dosage*; D012367:RNA, Viral / Q000032:analysis; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000821:virology
chemical_list: D018927:Anti-Asthmatic Agents; D000956:Antigens, Viral; D002867:Chromones; D004338:Drug Combinations; D020024:Leukotriene Antagonists; D012367:RNA, Viral; D011239:Prednisolone; C047681:pranlukast