title: The polymorphism analysis of CD169 and CD163 related with the risk of porcine reproductive and respiratory syndrome virus (PRRSV) infection.
abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) could infect porcine alveolar macrophages (PAM), and the CD169 and CD163 are identified as critical receptors on the surface of PAM, but whether the single nucleotide polymorphisms (SNPs) of these genes could influence the infection is remain unclear. In this study, we identified totally 6 SNPs for CD169 (G1640T, C1654A, C4175T) and CD163 (G2277A, A2552G and C2700A), and evaluated their associations with PRRSV infection using two classified methods in a 524 pig population to investigate the effects of mutations on the PRRSV receptors. The pigs with genotypes of AA of CD169-C1654A, CT of CD169-C4175T and AA of CD163-A2552G appeared to resistant to the PRRSV infection by the combination of two classified results. The results provided fundamental molecular investigation to promote pig breeding with disease resistance. However, the identification of functional changes induced by SNPs and molecular mechanism were need further research.
authors: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agriculture University, Hubei, 430070 Wuhan, China.
authors: Y W
authors: YW
authors: Ren
authors: Y Y
authors: YY
authors: Zhang
authors: N A
authors: NA
authors: Affara
authors: C A
authors: CA
authors: Sargent
authors: L G
authors: LG
authors: Yang
authors: J L
authors: JL
authors: Zhao
authors: L R
authors: LR
authors: Fang
authors: J J
authors: JJ
authors: Wu
authors: R
authors: R
authors: Fang
authors: Q
authors: Q
authors: Tong
authors: J
authors: J
authors: Xiao
authors: J L
authors: JL
authors: Li
authors: Y B
authors: YB
authors: Jiang
authors: H C
authors: HC
authors: Chen
authors: S J
authors: SJ
authors: Zhang
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics*; D002460:Cell Line; D005838:Genotype; D016676:Macrophages, Alveolar / Q000821:virology; D020641:Polymorphism, Single Nucleotide; D019318:Porcine Reproductive and Respiratory Syndrome / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics*; D063267:Sialic Acid Binding Ig-like Lectin 1 / Q000235:genetics*; D013552:Swine; D014764:Viral Proteins / Q000235:genetics*; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; D063267:Sialic Acid Binding Ig-like Lectin 1; D014764:Viral Proteins