Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD).
3xTg-AD mutant mice are characterized by parenchymal Aβ plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests, fewer fecal boli in an observation jar, and reduced enclosed arm entries and head-dipping in the elevated plus-maze. On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination.
Neurobehavioral Phenotyping Platform, Department of Molecular Medicine, Laval University and Laboratory of Endocrinology and Genomics, CHUQ Research Center, 2705 Blvd Laurier, Quebec, QC G1V 4G2, Canada. mohammed.filali@crchul.ulaval.ca
Mohammed
M
Filali
Robert
R
Lalonde
Peter
P
Theriault
Carl
C
Julien
Frederic
F
Calon
Emmanuel
E
Planel
D000222:Adaptation, Physiological / Q000235:genetics; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001362:Avoidance Learning; D003072:Cognition Disorders / Q000209:etiology*; D004192:Discrimination, Psychological; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D006801:Humans; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000209:etiology* / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D059225:Nociception / Q000502:physiology; D017288:Pain Threshold / Q000502:physiology; D053764:Presenilin-1 / Q000235:genetics; D011597:Psychomotor Performance / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology; D016875:tau Proteins / Q000235:genetics
D016564:Amyloid beta-Protein Precursor; C558298:Mapt protein, mouse; D053764:Presenilin-1; D016875:tau Proteins