[Changes of haemostatic parameters in patients with acute cardioembolic stroke].
Haemostatic parameters: platelet aggregation, hematocrit, fibrinogen, antithrombin III, fibrinolytic activity and euglobulin lysis time, plasminogen, plasminogen activator and anti-activator activity, thrombin- antithrombin and plasmin-antiplasmin complexes and serum von Willebrand factor were studied at the most acute stage of cardioembolic stroke (1-7 days after development of neurological symptoms). State of the vascular wall was assessed using the "cuff"-test. The activation of hemostasis in patients with cardioembolic stroke was characterized by the hypercoagulation and decrease of fibrinolysis and athrombogenic potential of vessel wall properties (antiaggregation, fibrinolytic and anticoagulative). In conclusion, haemostatic disbalance and decreasing of athrombotic potential of the vessel wall may be the indicator of embolism in patients with cardioembolic stroke.
M Iu
MIu
Maksimova
M A
MA
Domashenko
V G
VG
Ionova
V N
VN
Mikhal'chenko
E N
EN
Syskina
F R
FR
Okhtova
D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D001161:Arteriosclerosis / Q000150:complications*; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology; D004617:Embolism / Q000150:complications*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis; D005342:Fibrinolysis; D006331:Heart Diseases / Q000150:complications*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D010960:Plasminogen Activators / Q000032:analysis; D010974:Platelet Aggregation; D012712:Serum Globulins / Q000032:analysis; D020521:Stroke / Q000097:blood* / Q000209:etiology; D013917:Thrombin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis / Q000276:immunology
D000933:Antifibrinolytic Agents; D012712:Serum Globulins; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D000990:Antithrombin III; D005340:Fibrinogen; D010958:Plasminogen; D010960:Plasminogen Activators; D013917:Thrombin; D005341:Fibrinolysin