Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals.
OBJECTIVE
Lipid accumulation product (LAP) is an index, which combines waist circumference (WC) and triglyceride (TG) reflecting lipid accumulation. The aims of the study were to explore the relationship between LAP and insulin resistance (IR) and to assess whether LAP was superior to WC and body mass index (BMI) in identifying IR.


METHODS
The study was cross-sectional and included 2524 non-diabetic subjects from China. The blood pressure (BP), anthropometric measurements, glucose levels, insulin levels and a fasting lipid profile were measured. BMI, the homeostasis model assessment of IR (HOMA-IR) and LAP were calculated.


RESULTS
In both sexes, BP, BMI, total cholesterol (TC), non high-density lipoprotein cholesterol (non-HDL-C), HOMA-IR, fasting and postprandial glucose levels increased across LAP quartiles (P<0.001), while HDL cholesterol (HDL-C) levels decreased across LAP quartiles (P<0.001). Pearson's correlation analysis demonstrated that HOMA-IR was correlated with LAP, BMI, WC, TG, HDL-C and non-HDL-C in both sexes (P<0.001). Multivariate analysis demonstrated that LAP had a greater impact on HOMA-IR than BMI and WC.


CONCLUSIONS
LAP is closely associated with HOMA-IR and is a powerful index that outperforms BMI and WC in identifying IR in non-diabetic individuals.
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
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Xia
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Li
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Zhang
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Gong
W
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Ren
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Wang
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Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference / Q000502:physiology*; D055815:Young Adult
D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol