Antihyperglycemic activity of Woodfordia fruticosa (Kurz) flowers extracts in glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats.
The ethanolic extract of W. fruticosa flowers (250 and 500 mg/kg) significantly reduced fasting blood glucose level and increased insulin level after 21 days treatment in streptozotocin diabetic rats. The extract also increased catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase activities significantly and reduced lipid peroxidation. Glycolytic enzymes showed a significant increase in their levels while a significant decrease was observed in the levels of the gluconeogenic enzymes in ethanolic extract treated diabetic rats. The extract has a favourable effect on the histopathological changes of the pancreatic beta-cells in streptozotocin induced diabetic rats. The results suggest that W. fruticosa possess potential antihyperglycemic effect by regulating glucose homeostasis and antioxidant efficacy in streptozotocin-induced diabetic rats.
Department of Pharmacology, Goel Institute of Pharmacy & Sciences, Faizabad Road (Near Indira Canal), Lucknow 227 105, India. neerajcology@gmail.com
Neeraj
N
Verma
G
G
Amresh
P K
PK
Sahu
Ch V
ChV
Rao
Anil Pratap
AP
Singh
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D035264:Flowers / Q000737:chemistry; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D008658:Inactivation, Metabolic; D050417:Insulin-Secreting Cells / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031565:Woodfordia / Q000737:chemistry
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose