Antioxidant and anti-nitric oxide components from Quercus glauca.
From the ethanolic extract of Quercus glauca, two new lignans, (+)-5'-methoxyisolariciresinol-9'-O-α-L-rhamnopyranoside (1) and (7R,8S)-dihydrodehydrodiconiferyl alcohol 4-β-D-xyloside (2), along with fourteen known compounds including four lignanoids (3-6), five triterpenoids (7-11), two flavonoids (12, 13), two aromatics (14, 15), and one steroid (16) were isolated. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. Moreover, compounds 9 and 14 strongly inhibited nitric oxide (NO) production with IC<inf>50</inf> values of 8.25 and 14.04 µM, respectively, and compounds 1, 4-6, 14, and 15 showed moderate antioxidant activities.
National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC.
Chien-Chang
CC
Shen
Kun-Yuan
KY
Hong
Jennifer
J
Chen
Li-Jie
LJ
Zhang
Zhi-Hu
ZH
Lin
Hung-Tse
HT
Huang
Hui-Ling
HL
Cheng
Yao-Haur
YH
Kuo
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D000431:Ethanol / Q000737:chemistry; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D029963:Quercus / Q000737:chemistry*
C576305:(+)-5'-methoxyisolariciresinol-9'-O-alpha-L-rhamnopyranoside; C576304:(7R,8S)-dihydrodehydrodiconiferyl alcohol 4-beta-D-xyloside; D000975:Antioxidants; D017705:Lignans; D010936:Plant Extracts; D009569:Nitric Oxide; D000431:Ethanol