Microbiological outcomes of systemic ornidazole use in chronic periodontitis. Part II.
OBJECTIVE
Antimicrobials are increasingly being used as adjuncts to non-surgical or surgical periodontal therapy. The main purpose of the present analysis was to evaluate the effect of systemic ornidazole (ORN) on total anaerobic microbial counts of subjects with moderate to advanced chronic periodontitis (CP).


METHODS
This was a single-center, double-blinded, placebo-controlled, randomized clinical trial of six months duration. Fifty-eight subjects presenting with at least 12 teeth with probing depth (PD) > or = 4 mm were selected. Thirty subjects received full-mouth scaling and root planing (SRP) + placebo (control group) and 28 subjects received full-mouth SRP + ORN (test group). The total anaerobic counts were analyzed by collecting subgingival plaque from deepest pockets at baseline (B/L), 1 week, 1 month, 3 months and 6 months.


RESULTS
Paired and unpaired t-tests were used to determine the inter- and intra-group differences. Fifty subjects were evaluated up to six months. There was a significant difference in the number of anaerobes in the two groups at all the intervals except B/L (p<0.05).


CONCLUSIONS
The systemic use of ORN very efficiently reduced the microbial load in the group that received antibiotics.
Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India. periodonticsgdcri@gmail.com
A R
AR
Pradeep
Nitish
N
Kalra
N
N
Priyanka
Savitha B
SB
Naik
D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D058491:Bacterial Load / Q000187:drug effects; D002710:Chlorhexidine / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000188:drug therapy / Q000382:microbiology*; D003773:Dental Plaque / Q000382:microbiology; D012534:Dental Scaling; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use; D009910:Oral Hygiene; D009950:Ornidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D010919:Placebos; D016745:Root Planing; D013607:Tablets; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; D013607:Tablets; D009950:Ornidazole; D002710:Chlorhexidine