[Thyroid hormone profile in breast cancer patients in postmenopause].
OBJECTIVE
The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC).


METHODS
12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors.


RESULTS
Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR. TSH levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dL).


CONCLUSIONS
These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes.
Departamento de Clínica Médica, Universidade Estadual Paulista "Júlio de Mesquista Filho", Botucatu, SP, Brasil. condesan@yahoo.com.br
Sandro José
SJ
Conde
Renata de Azevedo Melo
Rde A
Luvizotto
Maria Teresa de
MT
Síbio
Patrícia Pinto
PP
Saraiva
Maria Mitzi
MM
Brentani
Célia Regina
CR
Nogueira
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002277:Carcinoma / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D049449:Luminescence; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D018709:Statistics, Nonparametric; D013959:Thyroid Diseases / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood*
D014408:Biomarkers, Tumor; D013963:Thyroid Hormones