LRRK2 A419V is not associated with Parkinson's disease in different Chinese populations.
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Linkou, Taiwan. yihruwu@adm.cgmh.org.tw
Yih Ru
YR
Wu
Louis C
LC
Tan
Xiaoli
X
Fu
Chiung Mei
CM
Chen
Wing Lok
WL
Au
Ling
L
Chen
Yi Chun
YC
Chen
Kumar M
KM
Prakash
Yifan
Y
Zheng
Guey-Jen
GJ
Lee-Chen
Yi
Y
Zhao
Jin-Sheng
JS
Zeng
Eng King
EK
Tan
Zhong
Z
Pei
D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors; D012846:Singapore; D013624:Taiwan
C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases