A case of IgG4-related sclerosing cholangitis overlapped with primary biliary cirrhosis.
IgG4-related sclerosing cholangitis (IgG4-SC) and primary biliary cirrhosis (PBC) can both cause liver dysfunction. While IgG4-SC is associated with IgG4-related diseases such as autoimmune pancreatitis, PBC is associated with various autoimmune diseases. However, there is only one case report of an association between IgG4-SC and PBC, and this association has not been elucidated further. The treatments for these two diseases are different, i.e., corticosteroid treatment is performed for IgG4-SC and ursodeoxycholic acid is given for PBC. We report a case of IgG4-SC overlapping with PBC in a 45-year-old man who was successfully treated by combination therapy with prednisolone and ursodeoxycholic acid.
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan.
Itaru
I
Naitoh
Takahiro
T
Nakazawa
Kazuki
K
Hayashi
Katsuyuki
K
Miyabe
Shuya
S
Shimizu
Hiromu
H
Kondo
Michihiro
M
Yoshida
Hiroaki
H
Yamashita
Shunsuke
S
Nojiri
Satoru
S
Takahashi
Takashi
T
Joh
D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D004359:Drug Therapy, Combination; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage
D007074:Immunoglobulin G; D014580:Ursodeoxycholic Acid; D011239:Prednisolone