Amyloid imaging mismatch.
An 82-year-old man with suspected systemic amyloidosis and complete atrioventricular block underwent vascular biopsy during his pacemaker implantation with pathology showing amyloid deposits. 99mTc-aprotinin SPECT revealed increased radiotracer uptake along the left ventricular wall, consistent with cardiac amyloidosis. 11C-PiB PET/CT performed for the evaluation of amyloid deposits in the brain showed findings suggestive of Alzheimer disease without abnormal radiotracer concentration in the myocardium to match the 99mTc-aprotinin SPECT findings. Dynamic PET images showed increased 11C-PiB concentration in the left ventricular myocardium at 2 minutes after injection, with subsequent tracer clearance by approximately 5 minutes, consistent with normal 11C-PiB biodistribution.
Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan. ryogominamimoto@yahoo.co.jp
Ryogo
R
Minamimoto
Kenji
K
Ishii
Kazuo
K
Kubota
Miyako
M
Morooka
Momoko
M
Okasaki
Kimiteru
K
Ito
Takuya
T
Mitsumoto
Kazuhiko
K
Nakajima
Takashi
T
Sato
Makoto
M
Mochizuki
Osamu
O
Okazaki
D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds; D007611:Aprotinin; D052160:Benzothiazoles; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography; D013844:Thiazoles; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D052160:Benzothiazoles; D015609:Organotechnetium Compounds; D013844:Thiazoles; C041381:technetium Tc 99m aprotinin; D007611:Aprotinin