Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
Katja
K
Mueller
Anne
A
von Mässenhausen
Ulrike
U
Aichele
Lilian
L
Stärck
Matthias
M
Leisegang
Wolfgang
W
Uckert
Hanspeter
H
Pircher
D000818:Animals; D000941:Antigens / Q000378:metabolism; D000956:Antigens, Viral / Q000737:chemistry*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D002462:Cell Membrane / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005434:Flow Cytometry / Q000379:methods; D006023:Glycoproteins / Q000737:chemistry*; D007371:Interferon-gamma / Q000378:metabolism; D008089:Listeria monocytogenes / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology; D008217:Lymphocytic choriomeningitis virus / Q000378:metabolism*; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry*; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000378:metabolism; D012190:Retroviridae / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D014764:Viral Proteins / Q000737:chemistry*
D000941:Antigens; D000956:Antigens, Viral; D016207:Cytokines; D006023:Glycoproteins; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D014764:Viral Proteins; C094244:glycoprotein peptide 33-41, Lymphocytic choriomeningitis virus; D007371:Interferon-gamma