Cytokines as regulators of proliferation and survival of healthy and malignant peripheral B cells.
Adaptive immunity depends on the production and maintenance of a pool of mature peripheral lymphocytes throughout life. The signals regulating the survival of mature splenic B cells have become a major focus in recent studies of B cell immunology. Lasting B cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. Cytokines have been shown to play a critical role in maintaining lymphocyte homeostasis. This review focuses on the role of cytokines and their receptors in the regulation of peripheral B cell survival, with an emphasis on those that have received relatively less attention in the literature.
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Sivan
S
Cohen
Idit
I
Shachar
D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D018121:Receptors, Cytokine / Q000276:immunology* / Q000378:metabolism; D013154:Spleen / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D018121:Receptors, Cytokine