Antiischemic activity of new domestic antioxidant 3-hydroxypyridine etoxidol derivative.
Experiments on rats with myocardium infarction showed that intravenous administration of etoxidol in a dose of 14.2 mg/kg restricted the size of necrosis area and reduced the ratio of necrosis/ischemia zones. The test compound reduced the risk of rhythm and conduction disturbances induced by administration of toxic epinephrine doses to the mice, and increased mouse survival. Etoxidol administered intravenously to cats with acute myocardial ischemia reduced epinephrine concentration and intensity of free radical oxidation in zones of myocardial lesions against the background of the increase in norepinephrine concentration and antioxidant activity in the myocardium. By antiischemic and antioxidant activity, etoxidol was superior to its structural analogue mexidol.
Medical Institute of N. P. Ogarev Mordovian State University, Saransk, Russia. blinovpharm@yandex.ru
D S
DS
Blinov
L N
LN
Sernov
V P
VP
Balashov
E V
EV
Blinova
L V
LV
Pivkina
E D
ED
Gogina
L V
LV
Van'kova
M V
MV
Vertyankin
G G
GG
Boiko
T V
TV
Krasilina
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000138:chemical synthesis; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D009336:Necrosis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D010847:Picolines / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage* / Q000138:chemical synthesis; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate
D000975:Antioxidants; D002395:Catecholamines; D005609:Free Radicals; D010847:Picolines; D011725:Pyridines; C014047:hydroxypyridines; C070020:emoxypine succinate; D004837:Epinephrine