Study of the nature of sympathetic trunk nerve fibers enhancing gastric motility.
Stimulation of the sympathetic nerve in the thoracic cavity often does not inhibit, but increases stomach contractions in dogs. Blockade of α- and β-adrenoceptors potentiates this stimulatory effect, while blockade of S(1,2)-receptors localized mainly in smooth muscle cells eliminates it. It is concluded that sympathetic nerve includes serotonergic fibers stimulating gastric motility.
Department of Physiology, Russian State Medical University, Moscow, Russia.
D S
DS
Sveshnikov
V M
VM
Smirnov
I L
IL
Myasnikov
A V
AV
Kuchuk
D018674:Adrenergic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004873:Ergolines; D005769:Gastrointestinal Motility / Q000502:physiology*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology; D059326:Serotonergic Neurons / Q000502:physiology*
D018674:Adrenergic Antagonists; D004873:Ergolines; D011433:Propranolol; C061884:lysergol; D010646:Phentolamine