[Comparison of the effects of alpha-keto/ amino acid supplemented low protein diet and diabetes diet in patients with diabetic nephropathy].
OBJECTIVE
To investigate if a-keto/amino acid supplemented low protein diet can slow down the progression of diabetic nephrophathy in comparison with non-supplemented diabetes diet.


METHODS
A prospective, randomized, controlled clinical study was conducted. Twenty three cases of type 2 diabetic nephropathy in IV stage were randomly divided into alpha-keto/amino acid supplemented diet group (trial group) and conventional diabetes diet group (control group), The treatment duration was 52 weeks. 24 h urine protein was measured at 0, 12, 20, 36 and 52 weeks. Before and after the 52 weeks treatment, all the patients received the measurement of glomerular filtration rate (GFR), blood glucose, blood lipids, inflammatory markers, as well as nutritional status.


RESULTS
After the treatment for 20, 36, 52 weeks, mean 24 h urine protein decreased significantly in trial groups (P < 0.05), and 24 h urine protein in trial group were significantly decreased (P < 0.05) compared with control group in 20 weeks after treatment. Either in trial group or in control group, GFR remained relatively stable during the observation period. Nutrition status, inflammatory markers, and serum calcium, phosphorus levels between the two groups were no significantly difference. The adverse events experienced by the patients in trial group were similar and consistent with the patients underlying renal diseases.


CONCLUSIONS
Alpha-keto/amino acid can reduce proteinuria more effectively, while improve renal function and nutritional status in diabetic nephropathy patients with well-toleration.
Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China.
Hong-yu
HY
Qiu
Fang
F
Liu
Li-jun
LJ
Zhao
Song-min
SM
Huang
Chuan
C
Zuo
Hui
H
Zhong
Feng
F
Chen
D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy; D003928:Diabetic Nephropathies / Q000178:diet therapy*; D003927:Diet, Diabetic; D018753:Diet, Protein-Restricted; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007651:Keto Acids / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011507:Proteinuria / Q000178:diet therapy
D000596:Amino Acids; D007651:Keto Acids