Screening rhodium metallopeptide libraries "on bead": asymmetric cyclopropanation and a solution to the enantiomer problem.
Searching with a beady eye: A high-throughput, on-bead screen of rhodium metallopeptide catalysts was developed in a 96-well format for asymmetric cyclopropanation. Different sequences of natural L-amino acids have been identified that produce opposite product enantiomers. In addition to styrene derivatives, high enantioselectivity is observed for vinyl ether and vinyl amine derivatives.
Department of Chemistry MS 60, Rice University, 6100 Main street, Houston, TX 77005, USA.
Ramya
R
Sambasivan
Zachary T
ZT
Ball
D000595:Amino Acid Sequence; D002384:Catalysis; D003521:Cyclopropanes / Q000737:chemistry*; D008667:Metalloproteins / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D003521:Cyclopropanes; D008667:Metalloproteins; D012238:Rhodium