Taq1B polymorphism of cholesteryl ester transfer protein (CETP) in Egyptian patients with metabolic syndrome.
OBJECTIVE
We aimed at evaluation of the possible association of cholesteryl ester transfer protein (CETP) Taq1B polymorphism with the components of metabolic syndrome in a cohort of Egyptian patients compared to their healthy counterparts.


METHODS
Blood samples were collected for lipid profile, fasting glucose, insulin and routine biochemical tests. The Taq1B genotypes of CETP were determined using RFLP-PCR technique.


RESULTS
The patients group showed a significantly higher B1B1 genotype and lower B2B2 genotype compared to the controls group. Serum HDL-C level was significantly higher in all subjects with the B2B2 genotype compared to those with B1B1 genotype. In the patients group, age positively correlated with cholesterol level, triglycerides, BMI and waist circumference.


CONCLUSIONS
Egyptian patients affected with metabolic syndrome have a higher prevalence of B1B1 genotype that is associated with lower serum HDL-C levels.
Department of Chemical Pathology, Medical Research Institute teaching Hospital, Alexandria University, Egypt. myelsammak@doctors.org.uk
Mohamed Y
MY
Elsammak
Rania M
RM
Al-Sharkaweey
Mohamed
M
Fahmy
Ahmed A
AA
Reda
Walla
W
Farid
Ahmed
A
Emara
Hesham
H
Hassan
Mona H
MH
Kandil
D000328:Adult; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D015331:Cohort Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000235:genetics*; D019914:Taq Polymerase / Q000235:genetics*
C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D019914:Taq Polymerase