Liquid chromatography and mass spectrometry of haem biosynthetic intermediates: a review.
This article discusses the separation, analysis and characterisation of intermediates and oxidative by-products of the haem biosynthetic pathway by liquid chromatography and mass spectrometry. Techniques reviewed include high-performance liquid chromatography, ultra-high-performance liquid chromatography, capillary electrophoresis, ion mobility spectrometry, mass spectrometry and tandem mass spectrometry. The emphasis was on the analysis of biological and clinical samples.
Clinical Biochemistry, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
Christopher M
CM
Benton
Chang Kee
CK
Lim
D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D006418:Heme / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D011164:Porphyrias
D006418:Heme