Efficacy of end-only-functionalized oligo(arylene-ethynylene)s in killing bacterial biofilms.
Cationic end-only-functionalized oligo(arylene-ethynylene)s (EO-OPEs) have recently been found to be broad-spectrum and effective antimicrobial agents because of their unique structure and optical properties. In this study, we investigated their potential use for preventing and reducing Escherichia coli (E. coli) biofilms. The Calgary biofilm device (CBD) was used to form bacterial biofilms of E. coli; in these studies, the minimum inhibitory concentration (MIC) and the minimum biofilm eradication concentration (MBEC) were determined. E. coli biofilms uniformly grow on pegs of the CBD device lid. The MIC values determined for EO-OPEs are comparable to those found for standard antibiotics such as kanamycin (MIC = 11.2 μg/mL). About 10-30 times the concentration of EO-OPEs was required to eradicate E. coli biofilms and prevent regrowth in the dark. Near-UV irradiation of EO-OPEs enhanced their efficacy in killing biofilms.
Department of Chemical and Nuclear Engineering and Center for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131-1341, United States.
Dimitri
D
Dascier
Eunkyung
E
Ji
Anand
A
Parthasarathy
Kirk S
KS
Schanze
David G
DG
Whitten
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D010100:Oxygen / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D026082:Singlet Oxygen; D010100:Oxygen