[Preparation and in vitro release characteristics of pulsed-release tablets of Apocynum venetum].
OBJECTIVE
Using Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics.


METHODS
The pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit The effect of formulation on pulsatile release of A. venetum was investigated.


RESULTS
The pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit. The delayed release time of the tablets was (5.0 +/- 0.5) h.


CONCLUSIONS
The pulsatile release characteristics of A. venetum pulsatile release tablets were confirmed in vitro.
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. yanghuasheng456@126.com
Huasheng
H
Yang
Fugui
F
Xie
Yuewen
Y
Yang
Yongming
Y
Luo
D030010:Apocynum / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D066298:In Vitro Techniques; D007785:Lactose / Q000031:analogs & derivatives / Q000032:analysis; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000032:analysis; D009997:Osmotic Pressure; D018515:Plant Leaves / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000032:analysis; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013997:Time Factors
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D011109:Polymethacrylic Acids; D013607:Tablets; C509290:hydroxypropylmethylcellulose-lactose matrix; C038300:methylmethacrylate-methacrylic acid copolymer; D008747:Methylcellulose; D007785:Lactose