Molecular imaging of stem cell transplantation for neurodegenerative diseases.
Cell replacement therapy with stem cells holds tremendous therapeutic potential for treating neurodegenerative diseases. Over the last decade, molecular imaging techniques have proven to be of great value in tracking transplanted cells and assessing the therapeutic efficacy. This current review summarizes the role and capabilities of different molecular imaging modalities including optical imaging, nuclear imaging and magnetic resonance imaging in the field of stem cell therapy for neurodegenerative disorders. We discuss current challenges and perspectives of these techniques and encompass updated information such as theranostic imaging and optogenetics in stem cell-based treatment of neurodegenerative diseases.
Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA.
Ping
P
Wang
Anna
A
Moore
D000818:Animals; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D057054:Molecular Imaging / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000503:physiopathology / Q000628:therapy*; D061848:Optical Imaging / Q000379:methods; D062308:Optogenetics / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*