The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, 200025, People's Republic of China.
Yan-Hua
YH
Deng
Lin
L
Zhao
Min-Jia
MJ
Zhang
Chun-Ming
CM
Pan
Shuang-Xia
SX
Zhao
Hong-Yan
HY
Zhao
Li-Hao
LH
Sun
Bei
B
Tao
Huai-Dong
HD
Song
Wei-Qing
WQ
Wang
Guang
G
Ning
Jian-Min
JM
Liu
D000058:Accidental Falls; D000328:Adult; D000368:Aged; D000375:Aging; D044466:Asian People; D015519:Bone Density; D002681:China; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D026161:MADS Domain Proteins / Q000235:genetics* / Q000378:metabolism; D064326:MEF2 Transcription Factors; D008875:Middle Aged; D018006:Myogenic Regulatory Factors / Q000235:genetics* / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000208:ethnology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D058866:Osteoporotic Fractures / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D053244:Osteoprotegerin / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011859:Radiography; D013049:Spectrin / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578040:MEF2C protein, human; D018006:Myogenic Regulatory Factors; D053244:Osteoprotegerin; C452439:SPTBN1 protein, human; C506030:TNFRSF11B protein, human; D013049:Spectrin