Elevation of vitamin D-binding protein levels in the plasma of patients with generalized aggressive periodontitis.
OBJECTIVE
Vitamin D-binding protein (DBP) is a multifunctional and highly expressed plasma protein. Among its diverse roles, including those in the immune and inflammatory responses, it is the primary carrier of vitamin D, which has been implicated in periodontitis. We hypothesized that there is a correlation between systemic DBP levels and generalized aggressive periodontitis (GAgP).


METHODS
Forty-four patients with GAgP and 32 healthy controls were recruited. Clinical parameters were examined, including the mean bleeding index, probing depth, attachment loss and percentage of severely affected sites. Blood chemistry analyses were performed for each subject. Plasma levels of DBP, interleukin-6 (IL-6) and procalcitonin (PCT) were measured using ELISAs, and plasma levels of 25-hydroxy-vitamin D(3) (25(OH)D(3)) were detected using a radioimmunoassay.


RESULTS
Significantly higher levels of plasma DBP, IL-6, PCT and 25(OH)D(3), as well as leukocyte counts, neutrophil counts and neutrophil percentages were found in patients with GAgP compared with healthy controls (p < 0.05 for all). Multiple linear regression analysis showed that the plasma DBP levels were significantly correlated with GAgP, plasma PCT levels and smoking status (p < 0.05 for all). In the GAgP group, the plasma DBP levels in smokers were significantly higher than those in nonsmokers (p < 0.001).


CONCLUSIONS
Elevated plasma vitamin DBP levels are associated with GAgP.
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
X
X
Zhang
H
H
Meng
X
X
Sun
L
L
Xu
L
L
Zhang
D
D
Shi
X
X
Feng
R
R
Lu
Z
Z
Chen
D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood*; D002112:Calcifediol / Q000097:blood; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D005884:Gingival Hemorrhage / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000473:pathology; D017622:Periodontal Attachment Loss / Q000097:blood; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D012907:Smoking / Q000097:blood; D014809:Vitamin D-Binding Protein / Q000097:blood*; D055815:Young Adult
C000606589:CALCA protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D011498:Protein Precursors; D014809:Vitamin D-Binding Protein; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D002112:Calcifediol