Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study.
Mitochondria produce cellular energy but also free-radicals, which damage cells despite an array of endogenous anti-oxidants. In Northern Europe, the mitochondrial haplogroup J has been related to longevity in nonagenarians and centenarians but also with age-related disease. Hypertension is an important contributor to atherosclerotic-related diseases and its pathogenesis is associated with increased oxidative stress. In this study, we questioned whether J haplogroup octo/nonagenarians from the Belfast Elderly Longitudinal Free-living Elderly STudy (BELFAST) study showed evidence of protective blood pressure or anti-oxidant profile which might explain their longevity advantage. Briefly, in a cross-sectional study, community-living, mentally alert (Folstein >25/30), octo/nonagenarian subjects, recruited for good health, were enlisted and consented as part of the BELFAST study, for blood pressure, anthropometric measurements and blood sampling. DNA typing for mitochondrial haplotypes was carried out with measurements for enzymatic and non-enzymatic antioxidants. J haplogroup carriers showed lower systolic blood pressure and glutathione peroxidase activity (Gpx) with higher folate measurements. There was no change in urate, bilirubin, albumin or nutrition-related antioxidants-selenium or vitamins A, C and α and β carotene. BELFAST study mtDNA J haplogroup octo/nonagenarians showed lower blood pressure and reduced glutathione peroxidase activity and higher folate, but no change for other antioxidants. These findings are of interest in view of mtDNA J haplogroup's association with increased age in some previous studies.
School of Medicine, Dentistry and Biomedical Science, Whitla Medical Building, Queen's University Belfast, BT9 7BL, Belfast, Northern Ireland, UK. i.rea@qub.ac.uk
Irene Maeve
IM
Rea
Susan E
SE
McNerlan
G Pooler
GP
Archbold
Derek
D
Middleton
Martin D
MD
Curran
Ian S
IS
Young
Owen A
OA
Ross
D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000235:genetics*; D000975:Antioxidants / Q000378:metabolism*; D001794:Blood Pressure / Q000235:genetics*; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008928:Mitochondria / Q000235:genetics*; D009660:Northern Ireland / Q000453:epidemiology; D018384:Oxidative Stress / Q000235:genetics*; D012189:Retrospective Studies
D000975:Antioxidants; D004272:DNA, Mitochondrial