Plasminogen-1 activator inhibitor gene 4G/5G promotor polymorphism and blood level of its protein product in hemorrhagic fever with renal syndrome.
The dynamics of plasma level of plasminogen-1 activator inhibitor (PAI-1) and frequency distribution of PAI-1 gene polymorphic locus 4G/5G genotypes and alleles were studied in male and female patients of different age with hemorrhagic fever complicated by renal syndrome of different severity. A significant elevation of PAI-1 level was recorded during fever in adult patients of mature age groups I and II with medium severe and severe uncomplicated disease, the elevation being followed by a significant reduction, except the oliguric and polyuric periods of medium severe form. In complicated disease, the concentration of PAI-1 was low during fever in patients of mature age group I, after which it increased significantly until the period of diuresis recovery; in patients of mature age group II it remained low, except the polyuria period. No appreciable age- or gender-related differences in frequency distributions of PAI-1 gene polymorphic locus 4G/5G genotypes and alleles in patients with disease of different severity were found; no differences from the control group by these parameters were revealed. The dynamics of PAI-1 plasma level in different forms of hemorrhagic fever with renal syndrome were not genetically determined and represented an adequate metabolic response to endotheliotropic virus.
Department of Biological Chemistry and Organic Biochemistry, Bashkir State Medical University, the Russian Ministry of Health, Ufa, Russia. baigildinaasia@mail.ru
A A
AA
Baygildina
D V
DV
Islamgulov
I R
IR
Minniakhmetov
D000328:Adult; D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D005838:Genotype; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood / Q000235:genetics*; D006801:Humans; D007668:Kidney; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012720:Severity of Illness Index
D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human