Formation of diclofenac molecular ions as the effect of Cu(2+)-π interaction under electrospray ionization mass spectrometry conditions.
Solutions containing diclofenac (M) and a copper salt [CuCl2, Cu(ClO4)2, Cu(NO3)2, CuSO4) were analysed by electrospray ionisation mass spectrometry (ESI-MS). Because of the cation-pi interactions in diclofenac-Cu(II) complexes, the diclofenac molecular ion M+* at m/z 295 was formed. It was found that the solvent composition (methanol versus water/methanol) and counter ion strongly affect the M+* ion formation. Formation pathways of ion M+* are discussed.
Adam Mickiewicz University, Faculty of Chemistry, Grunwaldzka 6, 60-780 Poznań, Poland.
Wojciech
W
Ostrowski
Katarzyna
K
Linko
Rafał
R
Frański
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D019327:Copper Sulfate / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D009566:Nitrates / Q000737:chemistry; D010472:Perchlorates / Q000737:chemistry; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007477:Ions; D009566:Nitrates; D010472:Perchlorates; D012996:Solutions; D014867:Water; C062280:copper(II) perchlorate; D004008:Diclofenac; D003300:Copper; C516433:copper(II) nitrate; D019327:Copper Sulfate; C029892:cupric chloride; D000432:Methanol