Structural characteristics of renal glomerular system in ISIAH rats under conditions of chronic stress and preventive hypotensive drug therapy.
The effects of chronic stress on the structure and function of the renal glomerular system were studied in hypertensive ISIAH rats treated with hypotensive drugs during the early ontogeny. The morphometric parameters of the renal glomerular system, characteristic of each of the experimental animal groups treated by enalapril, losartan, or terazosin in early age virtually did not change under conditions of stress exposure. These results indicate a persistent delayed nephroprotective effect of these drugs.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. eefil@physiol.ru
E E
EE
Filyushina
M D
MD
Shmerling
V A
VA
Lazarev
I I
II
Buzueva
A L
AL
Merkel
G S
GS
Yakobson
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000187:drug effects*; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D011224:Prazosin / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D013312:Stress, Physiological / Q000502:physiology*
D000959:Antihypertensive Agents; D004656:Enalapril; C041226:Terazosin; D019808:Losartan; D011224:Prazosin