Regeneration of red bone marrow in rat lower jaw after transplantation of mesenchymal stem cells into the site of injury.
Regeneration processes in rat mandibular bone after transplantation of a suspension of autologous BM MSC in culture medium were studied by methods of light microscopy and X-ray densitometry. It was found that the structures of red BM in the callus after transplantation of autologous BM MSC formed earlier than in natural reparation. The formation of cavities containing BM determines lower tissue density at the site of injury after transplantation of autologous BM MSC on weeks 4 and 5 of observation than during spontaneous healing. These changes progressed throughout the observation period and attested to accelerated bone tissue reparation.
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. imai@mail.ru
I V
IV
Maiborodin
V A
VA
Matveeva
I S
IS
Kolesnikov
M N
MN
Drovosekov
M S
MS
Toder
A I
AI
Shevela
D015502:Absorptiometry, Photon; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001861:Bone Regeneration; D008297:Male; D008334:Mandible / Q000473:pathology*; D008338:Mandibular Injuries / Q000473:pathology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D008853:Microscopy; D051381:Rats; D014182:Transplantation, Autologous; D014945:Wound Healing