Acute microbiologically negative hypoxic interstitial pneumonia on HAART: Immune Reconstitution Inflammatory Syndrome unmasking Pneumocystis jiroveci infection with an atypical presentation.
Highly active antiretroviral therapy for AIDS sometimes engenders inflammatory manifestations resulting from an inappropriate and unbalanced immune-system restoration, called Immune Reconstitution inflammatory Syndrome, which, in turn, can unmask a subclinical infection/pathology. Despite our patient's evident syndrome, the atypical clinical, microbiologic and radiologic feature of Pneumocystis pneumonia made its diagnosis difficult.
Department of Internal Medicine, Saint-Louis Hospital, AP-HP, Paris, France.
S
S
Sovaila
A
A
de Raigniac
C
C
Picard
O
O
Taulera
C
C
Lascoux-Combe
D
D
Sereni
A
A
Bourgarit
D000208:Acute Disease; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D054019:Immune Reconstitution Inflammatory Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D045363:Pneumocystis carinii / Q000502:physiology*; D011020:Pneumonia, Pneumocystis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed