Radiofrequency ablation as a possible method for preparing pathologically altered myocardium for intramyocardial cell transplantation.
We studied the effects of radiofrequency ablation on the results of intramyocardial transplantation of bone marrow NSC into the myocardium of rats with postinfarction cardiosclerosis. It was shown that exposure of the pathologically changed myocardium to radiofrequency radiation led to destruction of formed connective tissue. Transplantation of MSC into sites exposed to radiofrequency radiation promoted the development of regenerative processes (abundant infiltration with mononuclear cells, presence of granulation tissue, and numerous newly formed blood vessels). We concluded that preliminary radiofrequency irradiation of the myocardial areas promotes realization of the regenerative potential of cell transplantation.
Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. msg@cardio.tsu.ru
S A
SA
Afanas'ev
L P
LP
Tsapko
Yu V
YV
Rogovskaya
S V
SV
Popov
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D002465:Cell Movement; D015552:Injections, Intralesional; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000502:physiology; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D018919:Neovascularization, Physiologic; D061208:Pulsed Radiofrequency Treatment / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012598:Sclerosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods