Two streptothricins with a cis-streptolidine lactam moiety from Streptomyces sp. I08A 1776.
Two unique cis-fused streptothricins (1 and 2) were isolated from the culture broth of Streptomyces sp. I08A 1776. Their structures were determined by MS, CD, and 1D and 2D NMR spectroscopic data analysis. Compound 2 showed weak antibacterial activities against Bacillus subtilis and Enterococcus faecalis with MIC values of 32 and 64 μg ml(-1), respectively.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Maoluo
M
Gan
Yan
Y
Guan
Xudong
X
Zheng
Yanhui
Y
Yang
Xueqin
X
Hao
Yishuang
Y
Liu
Liyan
L
Yu
Chunling
C
Xiao
D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D001412:Bacillus subtilis / Q000187:drug effects; D003470:Culture Media / Q000737:chemistry; D013293:Enterococcus faecalis / Q000187:drug effects; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D013309:Streptothricins / Q000737:chemistry* / Q000302:isolation & purification*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D003470:Culture Media; D007769:Lactams; C003349:streptolidine; D013309:Streptothricins