Paying more than lip service to an oral lesion: a case of plasmablastic lymphoma.
Plasmablastic lymphoma (PBL) is a variant of lymphoma originally described in the oral cavity of patients with advanced HIV. Our patient developed PBL despite well-controlled HIV and a CD4 count greater than 800 cells/µl. A drug interaction with an inhaled corticosteroid and ritonavir likely contributed to the development of this malignancy through increased immune suppression.
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Yasbanoo
Y
Moayedi
Erik Steven
ES
Venos
Hasan
H
Ghaffar
Kevin A
KA
Gough
Lisa K
LK
Hicks
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004347:Drug Interactions / Q000276:immunology; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D009061:Mouth Mucosa / Q000276:immunology / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D019438:Ritonavir / Q000008:administration & dosage / Q000009:adverse effects*; D014750:Vincristine / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D017320:HIV Protease Inhibitors; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D019438:Ritonavir; D011241:Prednisone