The efficient desymmetrization of glycerol using scaffolding catalysis.
Glycerol is an ideal building block for the synthesis of complex molecules, because it is inexpensive and highly functionalized. We report the desymmetrization of glycerol through silyl transfer, using a chiral organic catalyst in high yield and enantioselectivity.
Boston College, Merkert Chemistry Center, 2609 Beacon, St. Chestnut Hill, MA 02467-3860, USA.
Zachary X
ZX
Giustra
Kian L
KL
Tan
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D005990:Glycerol / Q000737:chemistry*; D007700:Kinetics; D012821:Silanes / Q000737:chemistry; D013237:Stereoisomerism
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D012821:Silanes; D005990:Glycerol