The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population.
BACKGROUND
Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis.


METHODS
A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ²) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies.


RESULTS
Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement.


CONCLUSIONS
We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.
Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Wei-Chiao
WC
Chang
Peng Yeong
PY
Woon
Yu-Wen
YW
Hsu
Shengyu
S
Yang
Yi-Ching
YC
Chiu
Ming Feng
MF
Hou
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D000071740:ORAI1 Protein; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
D015220:Calcium Channels; D005819:Genetic Markers; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human