[Pathologic analysis of transbronchial lung biopsy in workers exposed to dusts].
OBJECTIVE
To explore the role of transbronchial lung biopsy (TBLB) in pathologic diagnosis of pneumoconiosis.


METHODS
In our hospital during May 2011 and Sep 2011, the TBLB samples from 35 cases occupationally exposed to dusts were compared with the video-assisted thoracoscopic surgery or lobectomy samples from 27 cases not exposed to dusts for pathological indexes, including fibrotic proliferation, nodule or nodule-like, dust deposition and needle-shaped birefringent particles.


RESULTS
In group exposed to dusts, there were 6 cases (17.1%) with the moderate dust deposition and 28 cases (80.0%) with fibrotic proliferation. But in group not exposed to dusts, there were 0 case with the moderate dust deposition and 11 cases (40.0%) with fibrotic proliferation. There were significant differences between two groups (P < 0.05). In group exposed to dusts, there were 6 cases (17.1%) with Nodules-like and needle-shaped birefringent particles, but in group not exposed to dusts, there was 0 case with Nodules-like and needle-shaped birefringent particles.


CONCLUSIONS
TBLB could provide the evidence of pathological changes in lung tissue induced by dusts, and TBLB play an important role in pneumoconiosis diagnosis.
Department of pneumoconiosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Ying
Y
Bi
Ling
L
Mao
Bin-sen
BS
Wang
Jin
J
Shi
Shao-wei
SW
Zhou
Zi-dan
ZD
Chen
Lu-qin
LQ
Bian
Yue
Y
Zhang
D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods*; D004391:Dust; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000175:diagnosis* / Q000473:pathology
D004391:Dust