[An overview of biomarkers in Alzheimer's disease].
Alzheimer's disease (AD), also called presenile dementia, is one of the most common neurodegenerative diseases in elderly people. The main pathological features of AD include senile plaques (SPs), neurofibrillary tangles (NFTs) and neuron loss. A biomarker is a characteristic that can be objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Class biomarkers of AD such as Abeta and phosphorylated tau have been widely used in clinical diagnosis of AD patients. Recently, novel technologies like proteomics, genomics, and imaging techniques have expanded the role of a biomarker from early diagnosis to monitoring the progression of diseases and evaluating the response to various treatments. In this article, we will review the progress of various biomarkers of AD.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xian-Fang
XF
Rong
Xiao-Liang
XL
Wang
D054392:Adipokines / Q000134:cerebrospinal fluid; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000032:analysis*; D000071451:Chitinase-3-Like Protein 1; D019788:Fluorodeoxyglucose F18; D006801:Humans; D037102:Lectins / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D010766:Phosphorylation; D049268:Positron-Emission Tomography; D053763:Presenilins / Q000032:analysis*; D000515:alpha 1-Antitrypsin / Q000097:blood; D016875:tau Proteins / Q000134:cerebrospinal fluid
D054392:Adipokines; D016229:Amyloid beta-Peptides; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D010446:Peptide Fragments; D053763:Presenilins; D000515:alpha 1-Antitrypsin; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D019788:Fluorodeoxyglucose F18