[Study on the effect using hemoperfusion to treat tylenol poisoned patients].
OBJECTIVE
To explore the effect of hemoperfusion (HP) on tylenol poisoned patients.


METHODS
Urgently established the blood access by transfemoral catheterization of femoral vein, we used charcoal hemoperfusion by blood pump and dynamically monitored the plasma concentration of tylenol active ingredients for the 2 patients and the content of tylenol active ingredients in the charcoal was determined.


RESULTS
Plasma concentration of tylenol active ingredients of the 2 patients was declined gradually during and after the HP management. The acetaminophen serum concentration of the case 1 was declined from the 13.4 µg/L at the start of HP to the 5.81 µg/L at the end of HP; and the case 2 was declined from 51.1 µg/L to 22.3 µg/L. The adsorption amount of acetaminophen in the blood perfusion device are respectively 119 542 µg of case 1 and 33 2154 µg of case 2.


CONCLUSIONS
Early hemoperfusion should be carried out for acute tylenol poisoning patients if there were indications, hemoperfusion can clear the tylenol active ingredients and this is an effective measure to eliminate tylenol active ingredients.
Emergency Department of The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015, China.
Deng-pan
DP
Lai
Xian-hua
XH
Ren
Ju-ping
JP
Yao
Mao-lin
ML
Liu
Gang
G
Xu
Zhao-jun
ZJ
Chen
Gui-lan
GL
Ling
D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood*; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008657:Metabolic Clearance Rate; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen