Biomimetic flavin-catalyzed aldehyde oxidation.
The oxidation of alkyl and aryl aldehydes to their corresponding carboxylic acids has been achieved through the action of a biomimetic bridged flavin catalyst. The reaction uses readily available 35% aqueous hydrogen peroxide and is operationally simple. The oxidation is a green and sustainable reaction, obviating chlorinated solvents with minimal byproducts.
Department of Chemistry, University of Bath , Bath BA2 7AY, United Kingdom, and GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom.
Alexander T
AT
Murray
Pascal
P
Matton
Nathan W G
NW
Fairhurst
Matthew P
MP
John
David R
DR
Carbery
D000447:Aldehydes / Q000737:chemistry*; D032701:Biomimetics; D002264:Carboxylic Acids / Q000737:chemistry*; D005415:Flavins / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry
D000447:Aldehydes; D002264:Carboxylic Acids; D005415:Flavins; D012997:Solvents; D006861:Hydrogen Peroxide