HLA class I-mediated control of HIV-1 in the Japanese population, in which the protective HLA-B*57 and HLA-B*27 alleles are absent.
We investigated the effect of HLA class I alleles on clinical parameters for HIV-1 disease progression in the Japanese population, where two strongly protective alleles, HLA-B*57 and HLA-B*27, are virtually nonexistent. HLA-B alleles showed a dominant role, primarily through HLA-B*67:01 and the HLA-B*52:01-C*12:02 haplotype. Neither a rare-allele nor a heterozygote advantage was found, suggesting that the effect of HLA alleles in the Japanese population is either different from those observed in Africans and Caucasians or undetectable due to limited power.
Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Takuya
T
Naruto
Hiroyuki
H
Gatanaga
George
G
Nelson
Keiko
K
Sakai
Mary
M
Carrington
Shinichi
S
Oka
Masafumi
M
Takiguchi
D000483:Alleles; D044383:Black People; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry; D015331:Cohort Studies; D018450:Disease Progression; D000939:Epitopes / Q000737:chemistry; D005006:Ethnicity; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control*; D006680:HLA Antigens / Q000737:chemistry* / Q000235:genetics; D015235:HLA-B Antigens / Q000737:chemistry* / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000737:chemistry* / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007564:Japan; D010641:Phenotype; D019562:Viral Load; D044465:White People
D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C103707:HLA-B57 antigen