Synthesis of bioactive natural products as protein inhibitors.
Synthetic studies of Annonaceous acetogenins isolated from the plant family Annonaceae and marine natural products (miraziridine A, tokaramide A, and callipeltins) containing unusual amino acids, and recent studies of the structure-activity relationship of cysteine protease inhibitor are described.
Department of Biological Engineering, Graduate School of Science and Technology, Yamagata University, Yamagata, Japan. konno@yz.yamagata-u.ac.jp
Hiroyuki
H
Konno
D054378:Acetogenins / Q000138:chemical synthesis*; D000818:Animals; D029061:Annonaceae / Q000737:chemistry; D001388:Aziridines / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis*; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis*; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D013329:Structure-Activity Relationship
D054378:Acetogenins; D001388:Aziridines; D001688:Biological Products; D015853:Cysteine Proteinase Inhibitors; D009842:Oligopeptides; D010456:Peptides, Cyclic; C516600:callipeltin B; C520377:callipeltin E; C490847:miraziridine A; C403246:tokaramide A