The therapeutic potential of 5-HT1A receptors: a patent review.
BACKGROUND
The 5-HT(1A) receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. Nearly 30 years of research in this field, there is still interest in developing new chemical entities capable of 5-HT(1A) receptor activation or blockade.


METHODS
This review article will highlight and review the research advances published in the patent literature between January 2007 and December 2011, giving emphasis to the medicinal chemist's standpoint. Literature search methodology included search in Scifinder and PubMed Databases and browsing clinicaltrials.gov website.


CONCLUSIONS
Almost no new therapeutic applications have been proposed for molecules targeting the 5-HT(1A) receptor, during the years covered by the present review. The discovery that stimulation of 5-HT(1A) receptor can promote neurogenesis will likely renew the interest for selective 5-HT(1A) receptor agonists as therapeutics to replace neural populations damaged by disease or injury.
Dipartimento Farmaco-Chimico, Università degli Studi di Bari A. Moro, via Orabona, 4, 70125 Bari, Italy.
Enza
E
Lacivita
Pantaleo
P
Di Pilato
Paola
P
De Giorgio
Nicola A
NA
Colabufo
Francesco
F
Berardi
Roberto
R
Perrone
Marcello
M
Leopoldo
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use; D002491:Central Nervous System Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007880:Legislation, Drug; D015394:Molecular Structure; D010330:Patents as Topic; D011619:Psychotropic Drugs / Q000627:therapeutic use; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects* / Q000378:metabolism; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000700:Analgesics; D000978:Antiparkinson Agents; D002491:Central Nervous System Agents; D011619:Psychotropic Drugs; D058829:Serotonin 5-HT1 Receptor Antagonists; D044282:Receptor, Serotonin, 5-HT1A