Transcriptional consequences of aneuploidy.
Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood. We have performed a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, plants, mice, and humans. We found highly related gene expression patterns that are conserved between species: genes that were involved in the response to stress were consistently upregulated, and genes associated with the cell cycle and cell proliferation were downregulated in aneuploid cells. Within species, different aneuploidies induced similar changes in gene expression, independent of the specific chromosomal aberrations. Taken together, our results demonstrate that aneuploidies of different chromosomes and in different organisms impact similar cellular pathways and cause a stereotypical antiproliferative response that must be overcome before transformation.
David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. sheltzer@mit.edu
Jason M
JM
Sheltzer
Eduardo M
EM
Torres
Maitreya J
MJ
Dunham
Angelika
A
Amon
D000782:Aneuploidy; D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D018506:Gene Expression Regulation, Plant / Q000502:physiology*; D006801:Humans; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D014158:Transcription, Genetic / Q000502:physiology*