A multidisciplinary approach to giant cell tumors of tendon sheath and synovium--a critical appraisal of literature and treatment proposal.
Giant cell tumors deriving from synovium are classified into a localized (GCT of tendon sheath; GCT-TS) and diffuse form (diffuse-type GCT, Dt-GCT). We propose a multidisciplinary management based upon a systematic review and authors' opinion. Open excision for GCT-TS and open synovectomy (plus excision) for Dt-GCT is advised to reduce the relatively high recurrence risk. External beam radiotherapy should be considered in severe cases, as Dt-GCT commonly extends extra-articular.
Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands. l.van_der_heijden@lumc.nl
Lizz
L
van der Heijden
C L Max H
CL
Gibbons
A Bass
AB
Hassan
Judith R
JR
Kroep
Hans
H
Gelderblom
Carla S P
CS
van Rijswijk
Remi A
RA
Nout
Kevin M
KM
Bradley
Nick A
NA
Athanasou
P D Sander
PD
Dijkstra
Pancras C W
PC
Hogendoorn
Michiel A J
MA
van de Sande
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001178:Arthroplasty; D001182:Arthroscopy; D001549:Benzamides; D017024:Chemotherapy, Adjuvant; D005260:Female; D005870:Giant Cell Tumors / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000627:therapeutic use; D033183:Interdisciplinary Communication; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000517:prevention & control; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000627:therapeutic use; D011758:Pyrroles / Q000627:therapeutic use; D011868:Radioisotopes / Q000627:therapeutic use; D018714:Radiotherapy, Adjuvant; D000077210:Sunitinib; D000074402:Synovectomy; D013583:Synovial Membrane / Q000473:pathology; D013710:Tendons / Q000473:pathology / Q000601:surgery; D013717:Tenosynovitis / Q000209:etiology
D000970:Antineoplastic Agents; D001549:Benzamides; D007211:Indoles; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D011868:Radioisotopes; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases; C498826:nilotinib; D000077210:Sunitinib