Interleukin 22-producing CD4+ T cells in malignant pleural effusion.
Th22 cells have been reported to be involved in human cancers. However, differentiation and immune regulation of Th22 cells in malignant pleural effusion (MPE) remain unknown. We noted that Th22 cell numbers were increased in MPE, and that IL-22 substantially promoted the proliferation and migratory activity of A549 cells. Moreover, IL-22 could strongly facilitate intercellular adhesion of A549 cells to pleural mesothelial cell monolayers. Our data revealed that the increase in Th22 cells in MPE was due to pleural cytokines and chemokines, and that Th22 exerted an important immune regulation on cancer cells in human pleural malignant environment.
Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China.
Zhi-Jian
ZJ
Ye
Qiong
Q
Zhou
Wen
W
Yin
Ming-Li
ML
Yuan
Wei-Bing
WB
Yang
Fei
F
Xiang
Jian-Chu
JC
Zhang
Jian-Bao
JB
Xin
Xian-Zhi
XZ
Xiong
Huan-Zhong
HZ
Shi
D000328:Adult; D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002633:Chemotaxis; D005260:Female; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D023421:Models, Animal; D016066:Pleural Effusion, Malignant / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D000097043:Interleukin-22
D007378:Interleukins; D000097043:Interleukin-22