Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA.
Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 P.R. China.
Shiyue
S
Duan
Weien
W
Yuan
Fei
F
Wu
Tuo
T
Jin
D000818:Animals; D019556:COS Cells; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004337:Drug Carriers; D007093:Imidazoles; D034741:RNA, Small Interfering; C576703:polyspermine imidazole-4,5-imine; D013096:Spermine