Pathways of bone marrow mononuclear cell differentiation after transplantation into postinfarction heart.
We studied homing and differentiation fate of transplanted bone marrow mononuclears after non-selective intracoronary injection on day 30 after acute myocardial infarction in rats. Mononuclear cells migrated to the cicatrix zone where they differentiated into fibroblasts and myofibroblasts. Mononuclear cells did not differentiate into cardiomyocytes, endothelial cells, or smooth muscle cells of vascular media. Stimulation of angiogenesis and reparation of the myocardium was observed under these conditions.
Laboratory of Growth and Development, Research Institute of Human Morphology, Russian Academy of Medical Sciences, Russian State Medical University, Moscow, Russia.
J P
JP
Baikova
T Kh
TKh
Fatkhudinov
G B
GB
Bolshakova
T B
TB
Buharova
T K
TK
Dubovaya
L V
LV
Kaktursky
D V
DV
Goldshtein
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D058948:Cell Tracking; D002921:Cicatrix / Q000473:pathology; D003331:Coronary Vessels / Q000503:physiopathology; D005347:Fibroblasts / Q000473:pathology; D006321:Heart / Q000502:physiology; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D058628:Myofibroblasts / Q000473:pathology; D018919:Neovascularization, Physiologic; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration