Design and synthesis of tryptophan containing peptides as potential analgesic and anti-inflammatory agents.
A new series of smaller peptides with tryptophan at C-terminal and varying N-protected amino acids/peptides were designed, synthesized and characterized by analytical and spectroscopic techniques. Analgesic and anti-inflammatory properties of these peptides were carried out in vivo using tail-flick method and carrageenan-induced paw edema method, respectively, at different doses and different time intervals. Most of the peptides synthesized displayed enhanced activity, and particularly tetra and hexapeptides 29-31 were found to be even more potent than the reference standards used. Moreover, some peptides have exhibited promising activity even after 24 h of administration, whereas the reference standards were active only up to 3 h. Further, the compounds did not present any ulcerogenic liability.
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India.
R
R
Suhas
D Channe
DC
Gowda
D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D014364:Tryptophan / Q000737:chemistry*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010455:Peptides; D014364:Tryptophan