Mechanisms of immune status disorders in chronic ethanol intoxication.
Experiments of outbred albino rats showed that chronic ethanol intoxication (20 days, summary dose 5 LD(50)) inhibited immune reactions mainly mediated by Th1-cells, increased blood corticosterone concentration, reduced T-lymphocyte acetylcholinesterase activity, blood concentrations of IFN-γ, IL-2, IL-4, IL-10, and increased IL-6 level.
Saratov State Medical University, Russia. pz@renet.com.ru
P F
PF
Zabrodskii
V G
VG
Lim
V A
VA
Grishin
A V
AV
Kuzmin
D000110:Acetylcholinesterase / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000097:blood / Q000276:immunology*; D000818:Animals; D021461:Animals, Outbred Strains; D002492:Central Nervous System Depressants / Q000633:toxicity*; D003345:Corticosterone / Q000097:blood; D016207:Cytokines / Q000097:blood; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D056724:Immunity, Humoral / Q000187:drug effects; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018417:Th1 Cells / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000201:enzymology / Q000276:immunology
D002492:Central Nervous System Depressants; D016207:Cytokines; D000431:Ethanol; D000110:Acetylcholinesterase; D003345:Corticosterone