Neurobiological correlates of delusion: beyond the salience attribution hypothesis.
Dopamine dysfunction is a mainstay of theories aimed to explain the neurobiological correlates of schizophrenia symptoms, particularly positive symptoms such as delusions and passivity phenomena. Based on studies revealing dopamine dysfunction in addiction research, it has been suggested that phasic or chaotic firing of dopaminergic neurons projecting to the (ventral) striatum attribute salience to otherwise irrelevant stimuli and thus contribute to delusional mood and delusion formation. Indeed, several neuroimaging studies revealed that neuronal encoding of usually irrelevant versus relevant stimuli is blunted in unmedicated schizophrenia patients, suggesting that some stimuli that are irrelevant for healthy controls acquire increased salience for psychotic patients. However, salience attribution per se may not suffice to explain anxieties and feelings of threat that often accompany paranoid ideation. Here, we suggest that beyond ventral striatal dysfunction, dopaminergic dysregulation in limbic areas such as the amygdala in interaction with prefrontal and temporal cortex may contribute to the formation of delusions and negative symptoms. Neuroleptic medication, on the other hand, appears to interfere with anticipation of reward in the ventral striatum and can thus contribute to secondary negative symptoms such as apathy and avolition.
Department of Psychiatry and Psychotherapy, Campus Charité Mitte,Charité-Universitätsmedizin Berlin, Berlin, Germany. anne.pankow@charite.de
Anne
A
Pankow
Astrid
A
Knobel
Martin
M
Voss
Andreas
A
Heinz
D000679:Amygdala / Q000378:metabolism / Q000503:physiopathology*; D014150:Antipsychotic Agents / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology*; D003702:Delusions / Q000378:metabolism / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism*; D059290:Dopaminergic Neurons / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D013702:Temporal Lobe / Q000378:metabolism / Q000503:physiopathology
D014150:Antipsychotic Agents; D004298:Dopamine