[Tissue distribution in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection].
OBJECTIVE
To determine the concentration in mice of danshensu from sodium danshensu and Salvia miltiorrhiza injection and undertake comparative study of them as well as to assess the effect of other components of S. miltiorrhiza injection on the tissue distribution of danshensu.


METHODS
Mice received intraperitoneal administration of sodium danshensu or S. miltiorrhiza injection (equal to danshensu 60 mg x kg(-1)) respectively, and was executed 30 minutes after administration. The concentration of danshensu in different tissues was separately determined by high performance liquid chromatographic method.


RESULTS
The characteristic profiles of sodium danshensu in different tissues were C(kidney) > C(spleen) > C(lung) > C(heart) > C(liver). The characteristic profiles of danshensu from S. miltiorrhiza injection in different tissues were C(kidney) > C(lung) > C(spleen) > C(heart) approximately C(liver). The concentration of danshensu in S. miltiorrhiza injection in liver and kindey was higher than sodium danshensu itself.


CONCLUSIONS
It was suggested that the other components in S. miltiorrhiza injection influent the distribution profile in tissues of danshensu.
Department of Pharmacology, Wannan Medical College, Institute of Quantitative Pharmacology, Grade III Laboratory, Pharmacology of Traditional Chinese Medical, State of Administration of Traditional Chinese Medicine of China, Wuhu 241002, China. wj001126@126.com
Juan
J
Wang
Zhangqing
Z
Ma
Zongyuan
Z
Hong
Jianguo
J
Song
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D007773:Lactates / Q000493:pharmacokinetics*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008168:Lung / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D028321:Plant Preparations / Q000493:pharmacokinetics; D027561:Salvia miltiorrhiza; D013154:Spleen / Q000737:chemistry / Q000378:metabolism; D014018:Tissue Distribution
D004365:Drugs, Chinese Herbal; D007773:Lactates; D028321:Plant Preparations; C035055:3,4-dihydroxyphenyllactic acid