[The observations of curative efficacy of rhubarb combined with blood purification on treatment patients with severe acute organophosphorus pesticide poisoning].
OBJECTIVE
To observe the curative efficacy of rhubarb, montmorillonite powder combined with blood purification on treatment for patients with severe acute organophosphorus pesticide poisoning (AOPP).


METHODS
39 patients with AOPP were divided into treatment group (received the combined treatment of rhubarb, montmorillonite powder and blood purification on the basis of routine therapy, n = 21) and control group (only received the routine treatment because of financial difficulties or the will of family members, n = 18). The differences of clinical manifestations, curative effects and prognosis between two groups were compared.


RESULTS
The time of consciousness recovery, the duration of mechanical ventilation and the length of stay in hospital in treatment group were (6.5 ± 1.3), (7.9 ± 2.0) and (13.1 ± 3.2) days, which were significantly shorter than those [(8.4 ± 2.4), (10.7 ± 2.9) and (16.5 ± 3.7) days] of control group (P < 0.05). In 5, 6 and 7 day after treatment,the cholinesterase (ChE) activities of treatment group were significantly higher than those of control group (P < 0.05). The total amount and using time of atropine and pyraloxime methylchloride in treatment group were significantly smaller and shorter than those in control group (P < 0.05). The death rate of treatment group was [19.0% (4/21)], which were significantly lower than that of control group [19.0% (4/21)] (P < 0.05).


CONCLUSIONS
The combined treatment of rhubarb, montmorillonite powder and blood purification of the AOPP patients has a better curative effect.
ICU The First Hospital of Jiaxing, Jiaxing, Zhejiang Province 314000, China.
Hui-jie
HJ
Yu
Dong-feng
DF
Shen
Bin
B
Liu
Yun-chao
YC
Shi
D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning / Q000628:therapy*; D010575:Pesticides / Q000506:poisoning*; D008517:Phytotherapy; D011379:Prognosis; D012250:Rheum; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D007306:Insecticides; D010575:Pesticides