Mutagenic activity of acrylamide in the rat thyroid cells under conditions of a subacute experiment.
Experimental mutagenic effect of acrylamide on thyroid gland cells was studied by an extended micronucleus test. Acrylamide in doses corresponding to 0.004-0.1 LD(50) increased the incidence of thyroid follicular cells (A-cells) with micronuclei and other karyological parameters in exposed rats after hemithyroidectomy. This cytogenetic effect allows regarding acrylamide as a mutagen for the thyroid gland and as a carcinogen for this organ.
A. N. Sysin Institute of Human Ecology and Environmental Hygiene, the Russian Academy of Medical Sciences, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia. alalan2@yandex.ru
A A
AA
Altaeva
L P
LP
Sycheva
N N
NN
Belyaeva
D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D008297:Male; D048629:Micronuclei, Chromosome-Defective; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects*
D009153:Mutagens; D020106:Acrylamide