A Case of Microangiopathic Antiphospholipid-Associated Syndromes during Pregnancy: Review of the Literature.
Microangiopathic antiphospholipid-associated syndromes (MAPSs) are reported as encompassing several conditions mainly affecting the microvasculature of selected organs: the liver in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet); kidney, brain, and skin in TTP (thrombotic thrombocytopenic purpura). It is predominant in patients with catastrophic antiphospholipid syndrome (APS). A recent report suggests that APS is not only a thrombotic disease but also associated with microangiopathic features, and it can explain the greater prevalence of HELLP syndrome in these patients. We here report a case of MAPS during pregnancy associated with systemic lupus erythematosus (SLE) in early second trimester.
Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, Nagoya 467-8601, Japan.
Nobuhiro
N
Suzumori
Shintaro
S
Obayashi
Kyoko
K
Kumagai
Shinobu
S
Goto
Atsuhiro
A
Yoshida
Mayumi
M
Sugiura-Ogasawara