Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population.
OBJECTIVE
Despite the high prevalence of depression and its considerable impact on the population, knowledge about the pathogenesis of the illness and the antidepressant treatment response is still unknown.


METHODS
A total of 397 patients with major depression disorder (MDD) and 473 normal controls were employed in the present research. Twelve single nucleotide polymorphisms (SNPs) within the adenomatous polyposis coli (APC) and receptor accessory protein (REEP5) genes were selected for genotyping using the GoldenGate genotyping assay. A total of 165 MDD patients completed a 6-week antidepressant treatment. Responders were defined as patients with at least a 50% reduction in Hamilton Rating Scale for Depression total scores posttreatment.


RESULTS
Two SNPs (rs2464805 and rs563556) within the APC gene exhibited a statistically significant association with MDD when analyzed by genotype and allele frequencies. Three SNPs (rs495794, rs153549 and rs153560) in the REEP5 gene showed significant statistical differences between the responders and nonresponders.


CONCLUSIONS
The APC gene may be one of the susceptibility genes for MDD as well as a genetic link between psychiatric disease and cancer. REEP5 gene polymorphisms may influence antidepressant treatment response in MDD.
The Psychiatric Laboratory and The Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan 610041, China.
Zhenxing
Z
Yang
Xiaohong
X
Ma
Yingcheng
Y
Wang
Jia
J
Wang
Bo
B
Xiang
Junyao
J
Wu
Wei
W
Deng
Mingli
M
Li
Qiang
Q
Wang
Tao
T
Li
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D002681:China / Q000208:ethnology; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D005260:Female; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D008969:Molecular Sequence Data; D017063:Outcome Assessment, Health Care; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
D000928:Antidepressive Agents; D008565:Membrane Proteins; C426247:REEP5 protein, human