Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.
Gold nanoparticles are known to activate anti-tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold-nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor-associated macrophages towards breast cancer cells in co-culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage-mediated delivery applications.
Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA.
Erik C
EC
Dreaden
Sandra C
SC
Mwakwari
Lauren A
LA
Austin
Matthew J
MJ
Kieffer
Adegboyega K
AK
Oyelere
Mostafa A
MA
El-Sayed
D000818:Animals; D001943:Breast Neoplasms; D016923:Cell Death / Q000187:drug effects; D003602:Cytotoxicity, Immunologic; D005260:Female; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D010587:Phagocytosis; D014407:Tumor Cells, Cultured
D018942:Macrolides; D006046:Gold