Effects and mechanisms of hemopoiesis-stimulating activity of immobilized oligonucleotides under conditions of cytostatic myelosuppression.
Hemopoiesis-stimulating activity of immobilized oligonucleotide preparation was studied on the model of cytostatic myelosuppression induced by injection of cyclophosphamide and 5-fluorouracil. Immobilized oligonucleotides stimulated regeneration of erythro- and granulocytopoiesis in the bone marrow under conditions of cytostatic treatment. The counts of neutrophilic granulocytes and platelets in the peripheral blood increased. The stimulatory effect of the drug was more manifest in animals with active behavior. The mechanism of immobilized oligonucleotide effect was based on stimulation of functional activity of erythroid and granulocytic macrophage precursors.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. dygay@rambler.ru
A M
AM
Dygai
V E
VE
Goldberg
A V
AV
Artamonov
A A
AA
Bekarev
E I
EI
Vereschagin
P G
PG
Madonov
E G
EG
Skurikhin
O V
OV
Pershina
T V
TV
Andreeva
E S
ES
Khmelevskaya
N N
NN
Ermakova
D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D002452:Cell Count; D003520:Cyclophosphamide / Q000008:administration & dosage; D054697:Cytostatic Agents / Q000008:administration & dosage; D004920:Erythropoiesis / Q000187:drug effects* / Q000502:physiology; D005472:Fluorouracil / Q000008:administration & dosage; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006397:Hematinics / Q000008:administration & dosage* / Q000737:chemistry; D007274:Injections, Intraperitoneal; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D038042:Myelopoiesis / Q000187:drug effects* / Q000502:physiology; D009841:Oligonucleotides / Q000008:administration & dosage* / Q000737:chemistry
D054697:Cytostatic Agents; D006397:Hematinics; D009841:Oligonucleotides; D003520:Cyclophosphamide; D005472:Fluorouracil