Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
BACKGROUND
Amyloid imaging provides in vivo detection of the fibrillar amyloid-β (Aβ) plaques of Alzheimer's disease (AD). The positron emission tomography (PET) ligand, Pittsburgh Compound-B (PiB-C11), is the most well studied amyloid imaging agent, but the short half-life of carbon-11 limits its clinical viability. Florbetapir-F18 recently demonstrated in vivo correlation with postmortem Aβ histopathology, but has not been directly compared with PiB-C11.


METHODS
Fourteen cognitively normal adults and 12 AD patients underwent PiB-C11 and florbetapir-F18 PET scans within a 28-day period.


RESULTS
Both ligands displayed highly significant group discrimination and correlation of regional uptake.


CONCLUSIONS
These data support the hypothesis that florbetapir-F18 provides comparable information with PiB-C11.
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. david.wolk@uphs.upenn.edu
David A
DA
Wolk
Zheng
Z
Zhang
Sanaa
S
Boudhar
Christopher M
CM
Clark
Michael J
MJ
Pontecorvo
Steven E
SE
Arnold
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D005026:Ethylene Glycols; D005260:Female; D006801:Humans; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D005026:Ethylene Glycols; D019275:Radiopharmaceuticals; D013844:Thiazoles; C545186:florbetapir