Phenolics from Bidens bipinnata and their amylase inhibitory properties.
A new chlorinated flavonoid, 3, 6, 8-trichloro-5, 7, 3', 4'-tetrahydroxyflavone (1), a new biscoumaric acid derivative, 4-O-(2″, 3″-O-diacetyl-6″-O-p-coumaroyl-β-D-glucopyranosyl)-p-coumaric acid (2), and 8, 3', 4'-trihydroxyflavone-7-O-β-D-glucopyranoside (3) together with twenty-four known compounds (4-27) were isolated from the whole plant of Bidens bipinnata. All chemical structures were established on the basis of UV-, MS- and NMR (¹H, ¹³C, ¹H-¹H COSY, HMQC and HMBC) spectroscopic data. Some of the isolated compounds were tested for the inhibition of α-amylase. The result showed that isookanin (6) was a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml).
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Xiao-Wei
XW
Yang
Min-Zhu
MZ
Huang
Yong-Sheng
YS
Jin
Lian-Na
LN
Sun
Yan
Y
Song
Hai-Sheng
HS
Chen
D000681:Amylases / Q000037:antagonists & inhibitors*; D031176:Bidens / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
D047188:Chalcones; D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D047309:Flavones; D010636:Phenols; D010936:Plant Extracts; C577175:isookanin; D000681:Amylases