[Storage at room temperature does not change cisatracurium onset time: a prospective, randomized, double-blind controlled study].
Storage of cisatracurium at room temperature seems to have no effect on its degradation in vitro contrary to the recommendations of storage at +4°C. The purpose of this study was to evaluate the influence of cisatracurium' s storage temperature on its onset time.



Prospective, randomized, double-blind trial study.



Thirty patients were enrolled. The control group consisted of 15 patients receiving cisatracurium (0.15mg/kg) stored at room temperature and the intervention consisted of 15 patients receiving cisatracurium (0.15mg/kg) stored at +4°C. The primary endpoint was to compare cisatracurium onset time depending on the storage temperature.



Cisatracurium onset time was 235 (180-292) seconds in the "room temperature" group vs. 240 (210-292) seconds in the "refrigerated" group. There was no difference between the onset of cisatracurium depending on the temperature of storage (p=0.51). Subgroups analysis in the "room temperature" group did not show any difference in cisatracurium onset depending on whether it was stored at room temperature for one, two or three weeks. Excellent intubation score was obtained for 100% of the patients.



This study demonstrated that cisatracurium's storage at room temperature had no influence on its onset time. It provides an argument for the preservation of cisatracurium at room temperature for a period not exceeding 21 days. Monitoring the onset of curarization may increase the quality score of intubation.
Pôle anesthésie-réanimation-médecine d'urgence, CHU d'Amiens, place Victor-Pauchet, 80000 Amiens, France. lorne.emmanuel@chu-amiens.fr
E
E
Lorne
D
D
Nuzzo
S
S
Suzanne
K-A
KA
Walczak
C
C
Perret
C
C
Laigle
N
N
Mattei
E
E
Dimov
S
S
Petiot
J
J
Godart
C
C
Pila
M-C
MC
Verdier
C
C
Chourbagi
M
M
Diouf
A
A
Friggeri
Y
Y
Mahjoub
H
H
Dupont
D000328:Adult; D000368:Aged; D000758:Anesthesia; D001279:Atracurium / Q000031:analogs & derivatives* / Q000737:chemistry; D004311:Double-Blind Method; D004355:Drug Stability; D004356:Drug Storage; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry*; D011446:Prospective Studies; D012034:Refrigeration; D013696:Temperature
D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; C101584:cisatracurium