Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype.
Obsessive-compulsive symptoms or obsessive-compulsive disorder (OCD) is estimated to occur in up to 30% of patients with schizophrenia. Whether this subgroup of patients is cognitively, affectively, or physiologically distinct remains unclear. 204 schizophrenia patients, 15 who also met criteria for a diagnosis of OCD, and 147 healthy controls were examined on several intermediate phenotypes. The patient groups did not differ from each other except that the co-morbid group exhibited an elevated rate of eye-tracking dysfunction. Results suggest that OCD-co-morbid patients did not comprise a distinct subgroup based on the measures studied here, although systematic assessment of larger cohorts is warranted.
Minneapolis Veterans Affairs Medical Center, Research 116A Building 68, One Veterans Drive, Minneapolis, MN 55417, USA. AnnaDocherty@mail.missouri.edu
Anna R
AR
Docherty
Michael J
MJ
Coleman
Xiawei
X
Tu
Curtis K
CK
Deutsch
Nancy R
NR
Mendell
Deborah L
DL
Levy
D000328:Adult; D003072:Cognition Disorders; D019465:Craniofacial Abnormalities; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D010641:Phenotype; D011618:Psychotic Disorders / Q000453:epidemiology / Q000503:physiopathology; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology*; D012565:Schizophrenic Psychology