Vascular endothelial growth factor and its receptors in the placenta of women with type 1 diabetes mellitus.
We performed a morphological study of placentas from women with type 1 diabetes mellitus receiving insulin therapy (insulin pump). Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was demonstrated by immunohistochemical methods. Processes of branched angiogenesis predominated in the placentas from women with type 1 diabetes mellitus. Immunohistochemical study revealed more intensive reaction of VEGF and its receptors in syncytiotrophoblast and capillary endothelium of terminal villi.
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia. dubovaea@gmail.com
E A
EA
Dubova
K A
KA
Pavlov
R M
RM
Esayan
E I
EI
Degtyareva
M V
MV
Shestakova
A I
AI
Shchegolev
G T
GT
Sukhikh
D002824:Chorionic Villi / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007328:Insulin / Q000627:therapeutic use; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D007328:Insulin; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor