Tissue engineering construct on the basis of multipotent stromal adipose tissue cells and Osteomatrix for regeneration of the bone tissue.
We developed a new method of creation of tissue engineering constructs for regeneration of the bone tissue based on the principle of free distribution of cells in a fibrin clot within a scaffold. The tissue engineering construct includes multipotent stromal adipose tissue cells committed in osteogenic lineage, platelet-rich plasma, and resorbed material on the basis of xenogeneic bone collagen. The culture of bone progenitor cells was characterized by the main markers of osteoblastic differon. The material meets all requirements for materials intended for tissue engineering. An innovative high-technological tissue engineering product for clinical application is prepared.
ReMeTeks Company, Moscow, Russia. bukharovarmt@yandex.ru
T B
TB
Bukharova
I V
IV
Arutyunyan
S A
SA
Shustrov
I S
IS
Alekseeva
I A
IA
Fedyunina
L V
LV
Logovskaya
A V
AV
Volkov
A A
AA
Rzhaninova
A S
AS
Grigor'yan
A A
AA
Kulakov
D V
DV
Gol'dshtein
D050153:Abdominal Fat / Q000166:cytology*; D000818:Animals; D001857:Bone Matrix; D001861:Bone Regeneration; D002113:Calcification, Physiologic; D002448:Cell Adhesion; D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D005337:Fibrin / Q000737:chemistry; D015870:Gene Expression; D039902:Multipotent Stem Cells / Q000378:metabolism / Q000502:physiology* / Q000637:transplantation; D015675:Osteocalcin / Q000235:genetics / Q000378:metabolism; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism; D053657:Platelet-Rich Plasma / Q000166:cytology; D011817:Rabbits; D018709:Statistics, Nonparametric; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D015675:Osteocalcin; D053495:Osteopontin; D005337:Fibrin