Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission.
During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts                 01605, USA.
Chun-Ting
CT
Chen
Heidi
H
Hehnly
Stephen J
SJ
Doxsey
D000818:Animals; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D048749:Cytokinesis / Q000502:physiology; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D011992:Endosomes / Q000502:physiology; D022022:Nuclear Pore / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction; D000097869:Polo-Like Kinase 1
D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1