Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats.
Maternal deprivation in the early postnatal period significantly affects the behavior and development of different animals. Here we studied delayed effects of daily maternal deprivation (5 h/day) on physical development and behavior of white rats during postnatal days 1 to 14. Here we studied the possibility of reducing the negative consequences of deprivation by daily intranasal treatment with Semax, an analog of ACTH(4-10), in a dose of 0.05 mg/kg from postnatal days 15 to 28. It was found that maternal deprivation decelerated the growth of young rats, boosted physical activity and emotional reactivity in novel environment, and increased anxiety in one-month-old animals. Semax weakened the impact of deprivation on animal body weight and normalized the levels of anxiety in rats.
InstDepartment of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
M A
MA
Volodina
E A
EA
Sebentsova
N Y
NY
Glazova
N G
NG
Levitskaya
L A
LA
Andreeva
D M
DM
Manchenko
A A
AA
Kamensky
N F
NF
Myasoedov
D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000517:prevention & control* / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004644:Emotions / Q000187:drug effects; D005260:Female; D008297:Male; D008426:Maternal Deprivation; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D018697:Nootropic Agents / Q000008:administration & dosage*; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats
D018697:Nootropic Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone