Role of prostaglandins in neuroinflammatory and neurodegenerative diseases.
Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.
Department of Pharmacology, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil.
Isabel Vieira de Assis
IV
Lima
Leandro Francisco Silva
LF
Bastos
Marcelo
M
Limborço-Filho
Bernd L
BL
Fiebich
Antonio Carlos Pinheiro
AC
de Oliveira
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*
D011453:Prostaglandins