Subcutaneous allergen immunotherapy for allergic disease: examining efficacy, safety and cost-effectiveness of current and novel formulations.
Subcutaneous immunotherapy (SCIT) is a unique therapy for allergic disease because it provides symptomatic relief while modifying the allergic disease by targeting the underlying immunological mechanism. Its efficacy and safety have been established in the treatment of asthma, allergic rhinitis/rhinoconjunctivitis and stinging insect hypersensitivity in numerous controlled clinical trials. This review evaluates a spectrum of clinical factors, ranging from efficacy to cost-effectiveness, which should be considered in evaluating SCIT. The evidence for SCIT safety and efficacy for these conditions is reviewed in an evaluation of the systematic reviews and meta-analyses. The evidence for the persistent and preventive effects of SCIT is also examined. An overview of the SCIT outcomes measures utilized in clinical trials is presented. The cost-effectiveness of SCIT compared with conventional medication treatment, novel indications and formulations for SCIT are also explored in this review.
Department of Medicine, Nova Southeastern University, 5333 North Dixie Highway, Fort Lauderdale, FL 33334, USA. lindaswolfcox@msn.com
Linda
L
Cox
Moisés
M
Calderón
Oliver
O
Pfaar
D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D003888:Desensitization, Immunologic / Q000379:methods* / Q000639:trends; D006801:Humans; D006967:Hypersensitivity / Q000191:economics / Q000276:immunology / Q000628:therapy*; D007279:Injections, Subcutaneous
D000485:Allergens