Heterobifunctional poly(ethylene glycol) derivatives for the surface modification of gold nanoparticles toward bone mineral targeting.
Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
Department of Pharmaceutical Technology, University of Regensburg, 93040 Regensburg, Germany.
Gamal M S
GM
Zayed
Joerg K V
JK
Tessmar
D040761:Biomimetic Materials / Q000737:chemistry; D018786:Bone Substitutes; D001842:Bone and Bones; D002113:Calcification, Physiologic; D002851:Chromatography, High Pressure Liquid; D003102:Colloids; D004164:Diphosphonates / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D017886:Durapatite / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000737:chemistry*; D013439:Sulfhydryl Reagents / Q000737:chemistry
D018786:Bone Substitutes; D003102:Colloids; D004164:Diphosphonates; D004337:Drug Carriers; D013439:Sulfhydryl Reagents; C104266:endobon; D011092:Polyethylene Glycols; D006046:Gold; D017886:Durapatite