Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy.
A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.
Sonidel Ltd., Dublin 5, Republic of Ireland.
Nikolitsa
N
Nomikou
Colin
C
Fowley
Niall M
NM
Byrne
Bridgeen
B
McCaughan
Anthony P
AP
McHale
John F
JF
Callan
D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D045423:Microbubbles / Q000627:therapeutic use*; D008954:Models, Biological; D015394:Molecular Structure; D009369:Neoplasms / Q000628:therapy*; D012395:Rose Bengal / Q000737:chemistry; D014463:Ultrasonography
D012395:Rose Bengal