Phosphoglucomutase activity as a novel biomarker in patients with acute myocardial infarction.
BACKGROUND
Phosphoglucomutase (PGM), a key enzyme in cellular glucose utilization and energy homeostasis, has been reported to show a relationship with oxidative stress. However, the clinical importance of PGM activity has not been investigated in patients with ischemic heart disease (IHD). The aim of the present pilot study was to clarify whether PGM activity has potential as a cardiovascular risk predictor in patients with IHD.


RESULTS
The levels of serum PGM activity in 237 patients with IHD (63 patients with acute myocardial infarction (AMI) and 174 patients with stable effort angina pectoris (EAP)) were evaluated. PGM activity was compared with levels of various myocardial, thrombosis, and inflammatory biomarkers on admission. PGM activity in the AMI group was significantly increased relative to that in the EAP group on admission (AMI, 55.5 μmol·min(-1)·L(-1) (U/L); EAP, 14.4 U/L (P<0.001)), and was observed to increase in parallel with well-established myocardial markers (P<0.001). Moreover, PGM activity and the lipid, thrombosis, and inflammatory biomarkers in the AMI group were higher than those in the EAP group.


CONCLUSIONS
PGM activity increased with levels of myocardial, thrombosis, and inflammatory biomarkers in patients with AMI, and might be useful in diagnostic applications during the acute phase in patients with AMI.
Department of Angio-Cardiology, Kitasato University School of Medicine, Sagamihara, Japan. makonishi@med.kitasato-u.ac.jp
Makoto
M
Nishinari
Naoyoshi
N
Aoyama
Zensuke
Z
Ogawa
Shogo
S
Yukino
Shusaku
S
Oka
Kouji
K
Yano
Yoshifumi
Y
Kurosaki
Ichiro
I
Takeuchi
Ryuta
R
Imaki
Taiki
T
Tojo
Takao
T
Shimohama
Hitoshi
H
Takehana
Tohru
T
Izumi
D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000201:enzymology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002417:Cattle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology*; D010733:Phosphoglucomutase / Q000097:blood*; D010865:Pilot Projects; D013927:Thrombosis / Q000097:blood / Q000201:enzymology
D015415:Biomarkers; D010733:Phosphoglucomutase