Effect of chelating agents and stress factors on zinc content in paneth cells and prostate gland cells.
The effects of chelating agents dithizone and sodium diethyldithiocarbamate on zinc content in Paneth cells and prostate gland cells were studied on rats preliminary exposed to stress factors (exercise and immobilization). Dithizone induced irreversible triphasic and sodium diethyldithiocarbamate reversible biphasic changes in zinc metabolism in cells. Preliminary stress potentiated the damaging effect of dithizone.
Siberian State Medical University, Tomsk, Russia; Zaporozhye National University, Ukraine.
V V
VV
Novitskiy
J V
JV
Eshchenko
V D
VD
Bovt
O I
OI
Urazova
V A
VA
Eshchenko
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D004230:Dithizone / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical / Q000502:physiology; D015032:Zinc / Q000378:metabolism*
D002614:Chelating Agents; D004230:Dithizone; D004050:Ditiocarb; D015032:Zinc