Does participation in clinical trials influence the implementation of new techniques? A look at changing techniques in breast radiotherapy in the UK.
OBJECTIVE
To examine the effect of UK breast radiotherapy trials on the adoption of new radiotherapy techniques over the last 15 years.


METHODS
The data were taken from questionnaires returned to the national radiotherapy quality assurance team for each of the major trials (START, Supremo, FAST, IMPORT) with additional information sought from heads of radiotherapy physics departments where needed.


RESULTS
The peak years for the introduction of three-dimensional radiotherapy corresponded to the opening of new trials requiring these techniques. Some non-trial centres had still not implemented three-dimensional techniques for breast cancer patients at the time the most recent questionnaire was completed (2009).


CONCLUSIONS
Clinical trials provide the framework and impetus for introducing more accurate radiotherapy for UK women with early breast cancer.
National Trials QA Team, Mount Vernon Hospital, Northwood, UK. karen.venables@nhs.net
K
K
Venables
Y
Y
Tsang
L
L
Ciurlionis
C E
CE
Coles
J R
JR
Yarnold
D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D011788:Quality of Life; D011878:Radiotherapy / Q000379:methods / Q000592:standards; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000592:standards; D011795:Surveys and Questionnaires; D006113:United Kingdom