Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations.
Two groups of breast cancer patients (53±2 years) in clinical remission receiving no specific therapy were examined: group 1, with BRCA1 gene mutations (N=11) and group 2, without mutations of this kind (N=11). The two groups did not differ by insulinemia and glycemia, insulin resistance index, blood levels of thyrotropic hormone, sex hormone-binding globulin, insulin-like growth factor-1, triglycerides, or lipoproteins. In group 1, blood estradiol level was higher. Intensive glucose-induced generation of reactive oxygen species in these patients was associated with a decrease of cholesterolemia, of the C-peptide/insulin proportion, and a trend to higher urinary excretion of 4-hydroxyestrone, one of the most genotoxic catecholestrogens. BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction.
N. N. Petrov Institute of Oncology, Ministry of Health and Social Development of the Russian Federation, St. Petersburg, Russia. levmb@endocrin.spb.ru
L M
LM
Berstein
M P
MP
Boyarkina
D A
DA
Vasilyev
T E
TE
Poroshina
I G
IG
Kovalenko
E N
EN
Imyanitov
V F
VF
Semiglazov
D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002096:C-Peptide / Q000097:blood; D004703:Endocrine System / Q000378:metabolism* / Q000473:pathology; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D006894:Hydroxyestrones / Q000652:urine; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009154:Mutation; D017382:Reactive Oxygen Species / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood; D014280:Triglycerides / Q000097:blood
D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D001786:Blood Glucose; D002096:C-Peptide; D006894:Hydroxyestrones; D007328:Insulin; D008074:Lipoproteins; D017382:Reactive Oxygen Species; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; C026418:4-hydroxyestrone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin