The effects of altered ultrasound parameters on the recovery of sciatic nerve injury.
Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves.



NMRI mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly selected. The animals were exposed to ultrasound radiation with various frequencies, intensities, and exposure time. They were allocated into 20 groups (19 treatment and 1 control groups). Sciatic functional index (SFI) test was used to evaluate the difference between the groups with respect to functional efficiency of the sciatic nerve and its recovery.



The results of SFI test obtained from the 14th day showed a significant difference among the groups (P<0.05). On the 14th day after treatment, one of the groups (US11) recovered up to 90%.



Altered ultrasound exposure parameters had more favorable outcomes compared with our previous work.
Dept. of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran 13164, Iran.
Zhamak
Z
Akhlaghi
Dept. of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran 13164, Iran.
Jalal Izadi
JI
Mobarakeh
Dept. of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran 13164, Iran.|Dept. of Biomedical Engineering in Electric Engineering, Iran University of Science and Technology, Tehran, Iran.
Mehrdad
M
Mokhtari
Dept. of Biomedical Engineering in Electric Engineering, Iran University of Science and Technology, Tehran, Iran.
Hamid
H
Behnam
Dept. of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran 13164, Iran.
Amir Abbas
AA
Rahimi
Faculty of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Mohammad Saleh
MS
Khajeh Hosseini
Faculty of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Farzaneh
F
Samiee
D000818:Animals; D051379:Mice; D009409:Nerve Crush; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000628:therapy*; D011897:Random Allocation; D020127:Recovery of Function; D012584:Sciatic Nerve / Q000293:injuries*; D020426:Sciatic Neuropathy / Q000628:therapy*; D014464:Ultrasonic Therapy