[Correlation analysis between the exposure levels and the serum protein fingerprints in population exposure to silica].
OBJECTIVE
To explore the correlation between the exposure levels and serum protein fingerprints in population exposed to silica.


METHODS
Liquid chip time-of-flight mass spectrometry technology was used to investigate the serum profiles in control group (30 cases), group exposed to silica (30 cases), silicosis group (I stage, 25 cases) and suspected silicosis group (30 cases), and screen the differential expression proteins. The correlation between the levels of the differential expression proteins and the exposure levels was performed.


RESULTS
Five differential expression proteins were found among 4 groups, the expression of 5081 and 5066 proteins was upregulated, and the expression of 3954, 2021 and 1777 proteins was downregulated. There was no the correlation between the exposure levels and the peak with M/Z among those proteins.


CONCLUSIONS
the results of present investigation indicated there was no correlation between the exposure levels and protein/peptide peak.
Key laboroctory Medical Diagnostics, Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Hai-xia
HX
Kong
Wei
W
Liu
Qing-bo
QB
Ma
Juan-juan
JJ
Chen
Mao-ti
MT
Wei
Shi-xin
SX
Wang
Ya-guang
YG
Weng
D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D004391:Dust / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D010449:Peptide Mapping; D040901:Proteomics; D012822:Silicon Dioxide / Q000633:toxicity*; D012829:Silicosis / Q000097:blood*
D001798:Blood Proteins; D004391:Dust; D012822:Silicon Dioxide