Efficiency of structurally different antioxidants in combined myocardial damage in mice.
Cardioprotective effects of derivatives of 3-hydroxypyridine, benzimidazole, and a peptide substance were studied on the model of combined damage to the myocardium (catecholamines and physical exercises) in mice. The most pronounced antioxidant and cardioprotective effects were produced by 3-hydroxypyridine acetylcysteinate (50 mg/kg), benzimidazole derivative Be-2m (50 mg/kg), and peptide substance γ-glutamyl histamine (1 mg/kg).
N. P. Ogarev Mordovian State University, Saransk, Russia. zamy03@mail.ru
M N
MN
Zamotaeva
V I
VI
Inchina
I N
IN
Chairkin
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D002118:Calcium / Q000097:blood; D009202:Cardiomyopathies / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D007273:Injections, Intramuscular; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry*; D010805:Physical Conditioning, Animal; D011188:Potassium / Q000097:blood; D011725:Pyridines / Q000737:chemistry*; D013997:Time Factors
D000975:Antioxidants; D001562:Benzimidazoles; D002316:Cardiotonic Agents; D009842:Oligopeptides; D011725:Pyridines; C120432:glutamyl-histamine; C023500:3-hydroxypyridine; C031000:benzimidazole; D003402:Creatine Kinase; D011188:Potassium; D002118:Calcium