Characteristics of antiamnestic effects of blockade and activation of dopamine D1 receptors after stress stimulation in mice.
Changes in the effects of D1-receptor activation and blockade on the amnesia induced by delay in unsafe compartment in mice after forced swimming were studied using conditioned passive avoidance test. The most pronounced antiamnestic effects in mice with behavioral despair reaction were observed after administration of D1 receptor antagonist SCH23390, while D1 receptor antagonist SKF38393 was most effective in mice without preliminary stimulation.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. dubrov@physiol.ru
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Dubrovina
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage*; D000647:Amnesia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001552:Benzazepines / Q000008:administration & dosage*; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D018491:Dopamine Agonists / Q000008:administration & dosage*; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013312:Stress, Physiological / Q000187:drug effects; D013550:Swimming
D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine