Effectiveness of correction of bleomycin-induced lung injury by early and late administration of surfactant-BL.
Rats were exposed to inhalation of surfactant-BL starting from the first or eighth day after intratracheal administration of bleomycin. At the early stages, the preparation effectively attenuated damage to ultrastructural components of the lung tissue and reduced the severity and extent of subsequent pulmonary pathology.
Russian Research Center of Radiology and Surgical Technologies, Federal Agency for High-Technological Medical Care, St. Petersburg, Russia. volchkov@biosurf.ru
V A
VA
Volchkov
V F
VF
Dubrovskaya
V A
VA
Serzhanina
A A
AA
Valkovich
O V
OV
Klestova
A A
AA
Seiliev
O A
OA
Rosenberg
D000280:Administration, Inhalation; D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage; D002417:Cattle; D004334:Drug Administration Schedule; D024022:Fibrillar Collagens / Q000032:analysis; D007962:Leukocytes / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D055370:Lung Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D011663:Pulmonary Surfactants / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D013997:Time Factors
D024022:Fibrillar Collagens; D011663:Pulmonary Surfactants; D001761:Bleomycin