Cisplatin-encapsulated organic nanotubes by endo-complexation in the hollow cylinder.
A bipolar glycolipid self-assembles into organic nanotubes upon its chelation with an anticancer drug cis-dichlorodiamineplatinum(II) (CDDP). The facile synthesis of glycolipid, chelation-assisted formation of the nanotubes, and efficient loading and prolonged release of CDDP demonstrate a new approach to high-axial supramolecular drug nanocarriers.
Nanotube Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, Higashi 1-1-1, Tsukuba 305-8565, Ibaraki, Japan.
Wuxiao
W
Ding
Momoyo
M
Wada
Hiroyuki
H
Minamikawa
Naohiro
N
Kameta
Mitsutoshi
M
Masuda
Toshimi
T
Shimizu
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006017:Glycolipids / Q000737:chemistry*; D008958:Models, Molecular; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D006017:Glycolipids; D002945:Cisplatin