Specifying cortical circuits: a role for cell lineage.
Two recent papers, Li et al. (2012) in Nature and Ohtsuki et al. (2012) in this issue of Neuron, show that lineage relationships between cortical neurons impact the development of specific connectivity and functional properties of cortical circuits. However, several differences between their results highlight important questions for future investigation.
Max Planck Florida Institute, Jupiter, FL 33458, USA.
Gordon B
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Smith
David
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Fitzpatrick