Sinonasal aspergillosis in dogs: a review.
Sinonasal aspergillosis is an uncommon, yet debilitating and often frustrating condition to treat in dogs despite years of research evaluating pathogenesis, diagnosis and treatment. The disease is most commonly caused by non-invasive fungal infection, thought to be secondary to altered innate and/or adaptive immune responses. Attempts to confirm this have however failed. A variety of conflicting opinions regarding the diagnosis and treatment of sinonasal aspergillosis exist. Often the use of a particular treatment protocol is based upon personal or regional preference. Evaluation of the veterinary literature demonstrates that the evidence base in support of individual treatment recommendations is weak. A number of recent publications have helped to expand the current knowledge base and therefore our understanding of important practicalities for both diagnostic options and treatment protocols. The following review examines the current evidence for the pathogenesis of sinonasal aspergillosis in dogs, as well as the various diagnostic options. The available evidence for frequently utilised -therapeutic options and their likely outcomes is also explored.
Veterinary Science, University of Melbourne, 250 Princes Highway, Werribee, Victoria, 3030, Australia.
M J
MJ
Sharman
C S
CS
Mansfield
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D001232:Aspergillus fumigatus / Q000302:isolation & purification / Q000472:pathogenicity*; D004283:Dog Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000517:prevention & control*; D004285:Dogs; D009668:Nose Diseases / Q000662:veterinary*; D016896:Treatment Outcome
D000935:Antifungal Agents