Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity.
Seven stilbenes and one alkylresorcinol were isolated from the orchid Phragmipedium calurum during a screen for anticancer compounds. They were evaluated for antiproliferative activity against multiple human cancer cell lines, and two displayed moderate activity against several cell lines.
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, United States. cstarks@sequoiasciences.com
Courtney M
CM
Starks
Russell B
RB
Williams
Vanessa L
VL
Norman
Julie A
JA
Lawrence
Mark
M
O'Neil-Johnson
Gary R
GR
Eldridge
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D029595:Orchidaceae / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012118:Resorcinols; D013267:Stilbenes; C031389:resorcinol