Opposite changes in cardiac chronotropy induced by selective blockade of α(1A)-adrenoceptors in rats of different age.
Selective blocker of α(1A)-adrenoceptors WB4101 induced changes in heart rate in rats: it caused bradycardia in 3-, 6-, or 20-week-old rats (severity of bradycardia increased with increasing animal age) and increased heart rate in newborn rat pups.
Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian-Pedagogical University, Kazan, Russia.
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Ziatdinova
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Zefirov
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Zefirov
D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001919:Bradycardia / Q000139:chemically induced; D004146:Dioxanes / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000254:growth & development; D006339:Heart Rate / Q000187:drug effects*; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*
D058668:Adrenergic alpha-1 Receptor Antagonists; D004146:Dioxanes; D018340:Receptors, Adrenergic, alpha-1; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane