Increased mammary uptake on 111In pentetreotide scintigraphy.
The normal scintigraphic features of 111In pentetreotide include uptake in the pituitary, thyroid, liver, spleen, kidneys, urinary bladder, gallbladder, and bowel. In premenopausal women, faint activity can be seen in the breasts. We present 2 cases of symmetrical, markedly increased mammary uptake. Our hypothesis to explain this pattern of uptake is an upregulation of the somatostatin type 2 receptor caused by high blood levels of estradiol during pregnancy. Estradiol levels during the menstrual cycle could therefore explain the variable degree of uptake commonly seen in premenopausal women.
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. s.vaneeckhoudt@erasmusmc.nl
Stoffel F J
SF
Van Eeckhoudt
Jaap J M
JJ
Teunissen
Dik J
DJ
Kwekkeboom
D000328:Adult; D001940:Breast / Q000000981:diagnostic imaging*; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism; D013004:Somatostatin / Q000031:analogs & derivatives*
D017481:Receptors, Somatostatin; D013004:Somatostatin; C093733:somatostatin receptor 2; C081788:pentetreotide