Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C-C coupling reactions.
The ephedrine-based diselenide appears as a new promiscuous catalyst, able to generate optically active alcohols by addition of organozinc to aldehydes (up to 97% ee), and shows powerful GPx like activity, reducing H(2)O(2) to water in only 16.33 min (eleven times faster than PhSeSePh).
NanoBio, Dpto de Química, CCNE, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Letiére C
LC
Soares
Eduardo E
EE
Alberto
Ricardo S
RS
Schwab
Paulo S
PS
Taube
Vanessa
V
Nascimento
Oscar E D
OE
Rodrigues
Antonio L
AL
Braga
D002384:Catalysis; D015195:Drug Design; D004809:Ephedrine / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000737:chemistry* / Q000378:metabolism; D018716:Molecular Mimicry; D016566:Organoselenium Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D016566:Organoselenium Compounds; D005979:Glutathione Peroxidase; D004809:Ephedrine