[Antitumor effect research progress of shikonin and its derivatives].
Shikonin, the main active ingredient of Lithospermum, and its derivatives have been proved to have antitumor effects, and the anti-tumor mechanisms involve multiple targets. Based on recent literatures, this review focuses on the antitumor effects and its mechanisms. More emphases are given on the aspects of induction of apoptosis, induction of necrosis, acting on matrix metalloproteinase, acting on the protein tyrosine kinase and antiangiogenesis. The current status and problems of shikonin derivatives in antitumor effects are simply summarized and lookout for the development of antitumor drugs with shikonin as leading compounds.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China.
Meng-Yuan
MY
Zhu
Ru-Bing
RB
Wang
Wen
W
Zhou
Shao-Shun
SS
Li
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D029684:Lithospermum / Q000737:chemistry*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D009336:Necrosis; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D010946:Plants, Medicinal / Q000737:chemistry; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D009285:Naphthoquinones; D017382:Reactive Oxygen Species; C016101:shikonin; D011505:Protein-Tyrosine Kinases; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9