Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis.
BACKGROUND
p53 tumor suppressor gene Arg72Pro polymorphism has been associated with gastric cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and gastric cancer.


METHODS
An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assess by pooled odds ratio (ORs) with 95% confidence interval (CIs).


RESULTS
The meta-analysis suggested that the p53 Arg72Pro was associated with the gastric cancer risk (Additive model: OR = 1.149, 95% CI = 1.045-1.263, p = 0.004; Dominant model: OR = 1.18, 95% CI = 1.049-1.328, p = 0.006; Recessive model: OR = 1.202, 95% CI = 1.013-1.427, p = 0.035) in Asian subgroup.


CONCLUSIONS
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Wenru
W
Tang
Xuhong
X
Zhou
Shengjie
S
Nie
Zhi
Z
Yang
Hui
H
Zhu
Xiaoming
X
Wu
Ruoping
R
Zhao
Ying
Y
Luo
D019943:Amino Acid Substitution; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53