Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo.
Aggregation of proteins liable to assembling into fibrils with subsequent formation of amyloid incorporations is an important component in the pathogenesis of many neurodegenerative diseases. Dimebon, a Russian drug, reduces the content of detergent-insoluble fibrillar forms of synuclein, the main protein component of pathological incorporations in neurons of transgenic mouse strain used in the study.
Department of Medical and Biological Chemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Russia. alexey@ipac.ac.ru
A A
AA
Ustyugov
T A
TA
Shelkovnikova
V S
VS
Kokhan
I V
IV
Khritankova
O
O
Peters
V L
VL
Buchman
S O
SO
Bachurin
N N
NN
Ninkina
D058227:Amyloidogenic Proteins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003902:Detergents / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D057149:Ubiquitinated Proteins / Q000235:genetics / Q000378:metabolism; D051845:gamma-Synuclein / Q000235:genetics* / Q000378:metabolism
D058227:Amyloidogenic Proteins; D003902:Detergents; D007211:Indoles; D018696:Neuroprotective Agents; D025801:Ubiquitin; D057149:Ubiquitinated Proteins; D051845:gamma-Synuclein; C010119:latrepirdine