Cytotoxic prodigiosin family pigments from Pseudoalteromonas sp. 1020R isolated from the Pacific coast of Japan.
Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.
Department of Environmental Systems Engineering, Kochi University of Technology, Kochi, Japan.
Yi
Y
Wang
Aya
A
Nakajima
Kakushi
K
Hosokawa
Azamjon B
AB
Soliev
Issey
I
Osaka
Ryuichi
R
Arakawa
Keiichi
K
Enomoto
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms / Q000737:chemistry; D053148:Caspase 3 / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D006801:Humans; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D031161:Pseudoalteromonas / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D020298:U937 Cells
D000970:Antineoplastic Agents; D010860:Pigments, Biological; D053148:Caspase 3; D011353:Prodigiosin