On the common mechanisms of cambial somatic and sex cells proliferation and the notion of the cambial cells.
Study of the early embryogenesis process based on the previously suggested scheme of epithelial cambial cell work has shown that cambial (or stem) cells originate from the primary ectoderm and intensely express RhoA protein and slightly express Src kinase. This explains their stem properties and the absence of differentiation. Primary sex cells are separated stem cells getting into an environment which expresses (to a certain measure) Src kinase in them and causes their polarization and specialization. In order to induce differentiation of cambial cells in a certain direction, expression of Src kinase should be stimulated to the needed degree in each tissue.
N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. Javisheva@rambler.ru
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Yavisheva
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Shcherbakov
D000818:Animals; D049109:Cell Proliferation; D004475:Ectoderm / Q000166:cytology; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D020742:rhoA GTP-Binding Protein / Q000235:genetics / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
D019061:src-Family Kinases; D020742:rhoA GTP-Binding Protein