Effects of L-selectin stimulation of the expression of chemokine receptor CXCR4 on NK cells of healthy donors and tumor patients.
We studied the effects of fucoidan (L-selectin ligand) on the expression and SDF-1-induced internalization of CXCR4 receptor on human NK cells of healthy donors and tumor patients. Fucoidan stimulated the expression of surface CXCR4 due to mobilization of the intracellular pool. The effect of fucoidan on CXCR4 expression in cancer patients was low. It was hypothesized that L-selectin-dependent migration of circulating NK cells along the SDF-1 chemokine gradient is reduced in cancer patients.
M. A. Aitkhozhin Institute of Molecular Biology and Biochemistry, Committee for Science, Ministry of Education and Science of Republic of Kazakhstan, Almaty, Kazakhstan. ulya2005@mail.ru
Yu V
YV
Perfilyeva
E A
EA
Kustova
N T
NT
Urazalieva
S A
SA
Baisheva
A T
AT
Aubakirova
R T
RT
Tleulieva
N N
NN
Belyaev
G K
GK
Zakiryanova
D000328:Adult; D000368:Aged; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000378:metabolism*; D019041:L-Selectin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000494:pharmacology; D019718:Receptors, CXCR4 / Q000378:metabolism*
D011134:Polysaccharides; D019718:Receptors, CXCR4; D019041:L-Selectin; C007789:fucoidan