From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD.
Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.
Department of CV & Metabolic DTA, F. Hoffmann-La Roche Ltd, Basel, Switzerland. marco.prunotto@gmail.com
Marco
M
Prunotto
David C
DC
Budd
Matthias
M
Meier
Ivan
I
Formentini
Guido
G
Hartmann
Silvia
S
Pomposiello
Solange
S
Moll
D058186:Acute Kidney Injury / Q000503:physiopathology*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*