[Studying the changes of the related serum complement immune indexes in patients with occupational medicamentosa-like dermatitis induced by trichloroethylene and workers occupationally exposed to trichloroethylene].
OBJECTIVE
To explore the mechanism of occupational medicamentosa-like dermatitis (OMDT) induced by trichloroethylene (TCE) and some immunity indexes in workers occupationally exposed to TCE.


METHODS
The blood samples from 8 cases with medicamentosa-like dermatitis in 1st, 2nd, 3rd, 4th and 5th weeks after admitting to hospital were examined for liver function, immunoglobulin and some complement indexes. Thirty nine workers occupationally exposed to TCE were investigated for urinary TCE and some immuno-complement indexes. The TCE concentrations of air in workplaces were monitored.


RESULTS
C3d-CIC and C3 of patients before admission were (92.86 ± 44.80) mg/L and 0.91 ± 0.19 mg/L, respectively. C3d-CIC and C3 of patients before discharge were (52.41 ± 17.75) mg/L and (1.14 ± 0.22) mg/L, respectively. There were significant differences between admission and discharge (P < 0.05). The average TCE concentration in 4 workplaces was (351.96 ± 36.72) mg/m(3), which was higher than the occupational exposure limits (OELs). The number of workers exposed to the TCE concentration-time weighted and TCA in urine over OELs were 28.21% and 56.41% of total subjects, respectively. The serum IgG and CIC levels of patients before discharge were (10.03 ± 1.21) mg/L and 103.50 ± 29.17 mU/L, which were significantly lower than those (17.21 ± 1.85) mg/L and (227.46 ± 111.67) mU/L of patients before admission (P < 0.01).


CONCLUSIONS
The type II and III hypersensitivity may be associated with OMDT and the organ injure induced by TCE.
Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou 510300, China.
Na
N
Zhao
Hai-lan
HL
Wang
Fei
F
Yue
Ze-ming
ZM
Zeng
Hong-ling
HL
Li
Yong-shun
YS
Huang
Run-tao
RT
Chen
D000293:Adolescent; D000328:Adult; D003165:Complement System Proteins / Q000276:immunology*; D009783:Dermatitis, Occupational / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D014241:Trichloroethylene / Q000633:toxicity*; D055815:Young Adult
D014241:Trichloroethylene; D003165:Complement System Proteins