2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature.
The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom.
Valeria
V
Azzarito
Panchami
P
Prabhakaran
Alice I
AI
Bartlett
Natasha S
NS
Murphy
Michaele J
MJ
Hardie
Colin A
CA
Kilner
Thomas A
TA
Edwards
Stuart L
SL
Warriner
Andrew J
AJ
Wilson
D000478:Alkylation; D001549:Benzamides / Q000737:chemistry*; D032701:Biomimetics; D015195:Drug Design; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D018716:Molecular Mimicry
D001549:Benzamides; C037689:benzamide