Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47(phox) subunit in monocytes from type 2 diabetes patients.
Hyperglycemia is a well-known inducing factor of oxidative stress through activation of NADPH oxidase. In addition to its plasma glucose lowering effect, insulin may also have antioxidant activity and was shown to downregulate NADPH oxidase expression in vitro. In this study, we show that a short-term (3-day) intravenous insulin infusion in patients with type 2 diabetes induces normalization of both glycemia and mRNA expression of circulating monocyte p47(phox) subunit.
Center of Pharmacology and Innovation in Diabetes, University Montpellier I, CNRS FRE 3400, 34093 Montpellier, France.
Guillaume
G
Vaquer
Richard
R
Magous
Gérard
G
Cros
Anne
A
Wojtusciszyn
Eric
E
Renard
Hughes
H
Chevassus
Pierre
P
Petit
Anne-Dominique
AD
Lajoix
Catherine
C
Oiry
D001786:Blood Glucose / Q000187:drug effects; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D019255:NADPH Oxidases / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D012333:RNA, Messenger; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1