Prenylated flavonoids from Desmodium caudatum and evaluation of their anti-MRSA activity.
Seven prenylated flavonoids and a prenylated chromanochroman derivative, together with eight known flavonoids, were isolated from roots of Desmodium caudatum. The 15 structures were elucidated by extensive spectroscopic analyses. The antibacterial activity of many of other compounds was evaluated against methicillin-resistant Staphylococcus aureus (MRSA: COL and 5) by a disc diffusion method, and the minimum inhibitory concentrations (MICs) to MRSA were determined.
Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima, Japan.
Hisako
H
Sasaki
Yoshiki
Y
Kashiwada
Hirofumi
H
Shibata
Yoshihisa
Y
Takaishi
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D054876:Prenylation
D000900:Anti-Bacterial Agents; D005419:Flavonoids