Characterization of the mechanical and biological properties of a new alumina scaffold.
OBJECTIVE
In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute.


METHODS
In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.


RESULTS
The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.


CONCLUSIONS
The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.
CICS-UBI - Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilhã - Portugal.
Patrícia S P
PS
Batista
Miguel A A
MA
Rodrigues
Daniela M R
DM
Silva
Patrícia I C
PI
Morgado
Joaquim P
JP
Henriques
Maria O
MO
Almeida
Abílio P
AP
Silva
Ilídio J
IJ
Correia
D000537:Aluminum Oxide / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008422:Materials Testing; D055595:Mechanical Phenomena; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry
D018786:Bone Substitutes; D000537:Aluminum Oxide