Ca2+ signaling in cerebellar Purkinje neurons--editorial.
Tight regulation of calcium (Ca(2+)) dynamics is critical for all neurons. Ca(2+) is a major mediator of cellular excitability, synaptic plasticity, and regulation of transcription, amongst others. Recent years have seen major developments in terms of understanding the roles of Ca(2+) signals in the cerebellar circuitry, especially for Purkinje neurons and granule cells. The unique morphology of Purkinje neurons serves as a platform to unravel the secrets of Ca(2+) homeostasis in cerebellar microcircuits. This special issue covers recent advances in Ca(2+) signaling and imaging, and highlights the importance of spatiotemporal compartmentalization underlying Ca(2+) dynamics. Sorting out the pieces of the puzzle of homeostatic regulation of Ca(2+) remains an instrumental step to start rational therapies of Ca(2+) deregulation.
Donna
D
Gruol
Mario
M
Manto
Duane
D
Haines
D000200:Action Potentials; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002525:Cerebellar Cortex / Q000166:cytology / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D018408:Patch-Clamp Techniques; D011689:Purkinje Cells / Q000502:physiology*