Effect of protein dynamics and solvent in ligand recognition by promiscuous aminoglycoside-modifying enzymes.
Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN, USA.
Engin H
EH
Serpersu
Adrianne L
AL
Norris
D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000617:Aminoglycosides / Q000737:chemistry* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008024:Ligands; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009713:Nucleotidyltransferases / Q000235:genetics / Q000378:metabolism; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012997:Solvents; D013379:Substrate Specificity; D013816:Thermodynamics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008024:Ligands; D012997:Solvents; D000123:Acetyltransferases; D010770:Phosphotransferases; D009713:Nucleotidyltransferases