Influenza A 2009 H1N1 encephalitis in adults with viral RNA in cerebrospinal fluid.
We present 3 cases of influenza A 2009 H1N1 encephalitis occurring in adults, corroborated by viral genome detection in cerebrospinal fluid (CSF) and evidence of meningeal inflammation on brain histopathology. This paper emphasizes the possibility of viral detection in CSF and stresses the lack of an effective treatment for neurological manifestations of influenza.
University of Zagreb School of Medicine, University Hospital for Infectious Diseases, Zagreb, Croatia. marija.santini@zg.t-com.hr
Marija
M
Santini
Marko
M
Kutleša
Kamelija
K
Zarković
Vladimir
V
Draženović
Bruno
B
Barsic
D001921:Brain / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000821:virology*; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000821:virology; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification*
D012367:RNA, Viral