Water-soluble constituents of the heartwood of Streblus asper.
A new lignan, (7'R,8'R)-threo-strebluslignanol-2-O-beta-D-glucopyranoside, along with 8 known compounds (2-9) were isolated from the water-soluble part of the MeOH extract of the heartwood of Streblus asper. Their structures were elucidated through various spectroscopic methods, including 1D NMR (1H NMR, 13C NMR), 2D NMR (HMQC, HMBC, and NOESY), and HRMS. The stereochemistry at the chiral centers was determined using the CD spectrum, as well as analyses of coupling constants and optical rotation data. In the preliminary bioassay, the isolated compounds did not show anti-HBV activities in vitro using the HBV transfected HepG2.2.15 cell line.
Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Ministry of Education of China), School of Environment and Resource of Guangxi Normal University, Guilin 541004, PR China. lijun9593@mailbox.gxnu.edu.cn
Jun
J
Li
Mao-Tong
MT
Tang
Qiang
Q
Wu
Hong
H
Chen
Xiao-Tao
XT
Niu
Xin-Lan
XL
Guan
Jian
J
Li
Sheng-Ping
SP
Deng
Xiao-Jian
XJ
Su
Rui-Yun
RY
Yang
D006515:Hepatitis B virus / Q000187:drug effects; D017705:Lignans / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D029586:Moraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis*; D012995:Solubility; D014867:Water / Q000737:chemistry
D017705:Lignans; D010936:Plant Extracts; D014867:Water