Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis.
OBJECTIVE
Portal hypertension and development of esophageal varices is one of the major complications of liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic liver cirrhosis.


METHODS
We included in our study 86 patients (74 males, mean age 55±7) with alcoholic liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical workup, upper digestive endoscopy and ultrasonography examination. The right liver lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with liver cirrhosis was also determined.


RESULTS
The mean value of right liver lobe diameter-albumin ratio was 6.15±1.77, and statistically significantly differed from values determined in the control group (4.97±1.68). The mean platelet count-spleen diameter ratio was 972.5±599.0 in alcoholic liver cirrhosis and 1055.9±821.3 in controls (p>0.05). In patients with alcoholic liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices.


CONCLUSIONS
Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.
Clinic for Gastroenterology, Clinical Center of Serbia, Belgrade, Yugoslavia. tamara.alempijevic@med.bg.ac
Tamara
T
Alempijevic
Aleksandra
A
Sokic-Milutinovic
Biljana
B
Milicic
Rada
R
Jesic
Ana
A
Balovic
Dragan
D
Popovic
Miodrag
M
Krstic
D015415:Biomarkers; D016022:Case-Control Studies; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D012709:Serum Albumin; D013154:Spleen / Q000473:pathology; D014463:Ultrasonography
D015415:Biomarkers; D012709:Serum Albumin