Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography.
A γ-AApeptide-based tracer for positron emission tomography imaging of integrin α(v)β(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin α(v)β(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.
Department of Radiology, University of Wisconsin - Madison, WI 53705, USA.
Yunan
Y
Yang
Youhong
Y
Niu
Hao
H
Hong
Haifan
H
Wu
Yin
Y
Zhang
Jonathan W
JW
Engle
Todd E
TE
Barnhart
Jianfeng
J
Cai
Weibo
W
Cai
D000818:Animals; D045744:Cell Line, Tumor; D003301:Copper Radioisotopes / Q000737:chemistry; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D007553:Isotope Labeling; D051379:Mice; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011402:Pronase / Q000378:metabolism; D011485:Protein Binding; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000378:metabolism*; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D003301:Copper Radioisotopes; D039302:Integrin alphaVbeta3; D010456:Peptides, Cyclic; D019275:Radiopharmaceuticals; C507169:cyclic arginine-glycine-aspartic acid peptide; D011402:Pronase