Mechanisms of antioxidant effect of natural sesquiterpene lactone and alkaloid derivatives.
We performed screening of potential antioxidants among natural lactone and alkaloid derivatives and characterized their antioxidant effects. The substances exhibiting antioxidant and metal-chelating potential, in particular, tryptamine derivatives, are promising neuroprotector agents.
Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia. neganova83@mail.ru
M E
ME
Neganova
S V
SV
Afanas'eva
S G
SG
Klochkov
E F
EF
Shevtsova
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013858:Thiobarbiturates; D014020:Tissue Extracts / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000470:Alkaloids; D000975:Antioxidants; D002614:Chelating Agents; D005609:Free Radicals; D018696:Neuroprotective Agents; D012717:Sesquiterpenes; D013858:Thiobarbiturates; D014020:Tissue Extracts; C029684:thiobarbituric acid