[Transdermal behavior of effective constituents in xuanbi gel plaster].
OBJECTIVE
To study the transdermal absorbability of gentiopicroside, naringin and protosappanin B contained in Xuanbi gel plaster.


METHODS
The Franz diffusing cells method was adopted for the in vitro model of rat belly skins. Three indexes, gentiopicroside, naringin and protosappanin B, residued in the accept liquid, skins and plaster were determined by HPLC.


RESULTS
The penetration rates of gentiopicroside, naringin and protosappanin B were respectively 3.47, 1.59, 2.13 microg x cm(-2) x h(-1). After 24 h, their penetration rates were 25.42%, 11.73%, 17.78%, respectively. The residual quantities of gentiopieroside, naringin and protosappanin B in skin were 0.231, 0.593, 0.568 microg x cm(-2), ith the retention rates of 0.027%, 0.227%, 0.475%, respectively. The amount of residue of gentiopicroside, naringin and protosappanin B in plaster were 2179, 674, 278 microg, with the retention rates of 81.36%, 81.92%, 73.83%, respectively.


CONCLUSIONS
The in vitro transdermal behavior of Xuanbi gel plaster is close to a zero-order process. The residual quantity the retention rate in skins is much lower than the penetration rate and the residual rate in plaster.
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. rita_liu009@163.com
Yuehuan
Y
Liu
Yang
Y
Lu
Shouying
S
Du
Jie
J
Bai
Yue
Y
Wang
Huiyun
H
Li
D000279:Administration, Cutaneous; D000818:Animals; D044950:Flavanones / Q000378:metabolism; D005782:Gels / Q000737:chemistry; D057888:Iridoid Glucosides / Q000378:metabolism*; D008297:Male; D010636:Phenols / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption
D044950:Flavanones; D005782:Gels; D057888:Iridoid Glucosides; D010636:Phenols; C012997:gentiopicroside; C005274:naringin