[Feature analysis of IDH1 mutation in oligodendroglial tumors].
OBJECTIVE
To analyze the features of isocitrate dehydrogenase 1 (IDH 1) mutation in 165 oligodendroglial tumors.


METHODS
IDH1 was detected in a series of 165 oligodendroglial paraffin specimens from 2009 to 2011. And their features were analyzed.


RESULTS
Mutant IDH1 was detected in 111 (67.3%) tumors including 109 (98.2%) CGT→CAT mutations, 1 (0.9%) CGT→AGT mutation and 1 (0.9%) CGT→TGT mutation. The frequencies of IDH mutation in AO, O and OA were 13/15, 83.3% and 72.9% respectively. They were significantly higher than that in AOA (27.0%, P < 0.001).


CONCLUSIONS
The different frequencies of IDH1 mutation in different subsets of oligodendroglial tumors may imply varied tumorigenic pathways between subsets.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Xiao-hui
XH
Ren
Xiang-li
XL
Cui
Zhi-mei
ZM
Shang
Song
S
Lin
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005910:Glioma / Q000235:genetics*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D055815:Young Adult
D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human