Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases.
We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats.
Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Moscow, Russia. milyausha78@mail.ru
M Kh
MKh
Salimgareeva
R S
RS
Yamidanov
Yu V
YV
Vakhitova
S B
SB
Seredenin
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D003720:Densitometry; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D015151:Immunoblotting; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*
D019208:Brain-Derived Neurotrophic Factor; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D009414:Nerve Growth Factors; D048049:Extracellular Signal-Regulated MAP Kinases; D000218:Adamantane