Histological investigation of resected dura mater attached to spinal meningioma.
METHODS
Histological observational study of patients with spinal meningioma.


OBJECTIVE
To clarify the status of tumor cell invasion into the dura mater and to provide fundamental information for appropriate management of dural attachment.


BACKGROUND
Histological appearance of the dura attached to spinal meningioma has not been sufficiently evaluated.


METHODS
Dura mater resected in a Simpson Grade 1 manner from 25 consecutive patients with spinal meningiomas (World Health Organization grade 1) was histologically observed to determine the status of tumor cell invasion. As no clear borders such as a tumor capsule between tumor and dura mater were observed, histological findings of the dura mater were classified into the following 3 categories: grade 1, no dural invasion, with only inflammation of the dura; grade 2: dural invasion below the zone between the inner and outer layers; and grade 3, dural invasion into or over the zone between the inner and outer layers (full-thickness invasion).


RESULTS
In our microscopic study, 19 of the 25 cases of spinal meningioma showed evidence of dural invasion and 15 cases showed full-thickness invasion.


CONCLUSIONS
This histological investigation of resected dura mater attached to spinal meningioma showed a high rate of full-thickness tumor invasion into the dura mater.
Department of Orthopedics, Faculty of Medicine, Jichi Medical University, Tochigi, Japan.
Kenichi
K
Yamamuro
Atsushi
A
Seichi
Atsushi
A
Kimura
Ichiro
I
Kikkawa
Masahiro
M
Kojima
Hirokazu
H
Inoue
Yuichi
Y
Hoshino
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002574:Cervical Vertebrae; D004388:Dura Mater / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D012189:Retrospective Studies; D013904:Thoracic Vertebrae