The molecular determinants of CD8 co-receptor function.
CD8(+) T cells respond to signals mediated through a specific interaction between the T-cell receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between the polymorphic α1 and α2 helices of an MHC class I (MHCI) molecule. The CD8 glycoprotein 'co-receives' antigen by binding to an invariant region of the MHCI molecule and can enhance ligand recognition by up to 1 million-fold. In recent years, a number of structural and biophysical investigations have shed light on the role of the CD8 co-receptor during T-cell antigen recognition. Here, we provide a collated resource for these data, and discuss how the structural and biophysical parameters governing CD8 co-receptor function further our understanding of T-cell cross-reactivity and the productive engagement of low-affinity antigenic ligands.
Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. coledk@cardiff.ac.uk
David K
DK
Cole
Bruno
B
Laugel
Mathew
M
Clement
David A
DA
Price
Linda
L
Wooldridge
Andrew K
AK
Sewell
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*
C067361:CD8 receptor; D008024:Ligands; D011948:Receptors, Antigen, T-Cell