A self-assembled cage as a non-covalent protective group: regioselectivity control in the nucleophilic substitution of aryl-substituted allylic chlorides.
Aryl-substituted allylic chlorides are accommodated by a self-assembled cage in such a restricted orientation that the internal reaction sites are shielded while the external ones are exposed. This non-covalent protection enhances terminal regioselectivity in the allylic substitution.
Department of Applied Chemistry, School of Engineering, The University of Tokyo and CREST, Japan Science and Technology Agency, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Yuh
Y
Kohyama
Takashi
T
Murase
Makoto
M
Fujita