The secret lives of experiments: methods reporting in the fMRI literature.
Replication of research findings is critical to the progress of scientific understanding. Accordingly, most scientific journals require authors to report experimental procedures in sufficient detail for independent researchers to replicate their work. To what extent do research reports in the functional neuroimaging literature live up to this standard? The present study evaluated methods reporting and methodological choices across 241 recent fMRI articles. Many studies did not report critical methodological details with regard to experimental design, data acquisition, and analysis. Further, many studies were underpowered to detect any but the largest statistical effects. Finally, data collection and analysis methods were highly flexible across studies, with nearly as many unique analysis pipelines as there were studies in the sample. Because the rate of false positive results is thought to increase with the flexibility of experimental designs, the field of functional neuroimaging may be particularly vulnerable to false positives. In sum, the present study documented significant gaps in methods reporting among fMRI studies. Improved methodological descriptions in research reports would yield significant benefits for the field.
University of Michigan, Department of Psychology, 530 Church Street, Ann Arbor, MI, 48109, USA. jmcarp@umich.edu
Joshua
J
Carp
D035843:Biomedical Research / Q000706:statistics & numerical data*; D001931:Brain Mapping / Q000706:statistics & numerical data*; D006801:Humans; D063369:Knowledge Discovery / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D010506:Periodicals as Topic / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity