Role of prostatic epithelium basement membrane incompetence in the pathogenesis of chronic prostatitis.
Prostatic inflammation is associated with infections penetrating through the urethra. This inflammation is treated by long courses of wide-spectrum antibiotics. However, the most frequent cause of prostatitis is Escherichia coli and other enteric flora. Electron microscopy of biopsy specimens from the prostate detected gaps in the prostatic epithelium basement membrane, their size explaining the penetration of enteric flora into the prostate. These data suggest another view on the pathogenesis of prostatitis and approaches to improvement of therapy for this disease.
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. s.stovbun@chph.ras.ru
S V
SV
Stovbun
M A
MA
Gomberg
E E
EE
Bragina
V E
VE
Sergienko
D000368:Aged; D001485:Basement Membrane / Q000382:microbiology / Q000648:ultrastructure*; D001706:Biopsy; D002908:Chronic Disease; D004848:Epithelium / Q000382:microbiology / Q000648:ultrastructure*; D004926:Escherichia coli / Q000502:physiology; D004927:Escherichia coli Infections / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011467:Prostate; D011472:Prostatitis / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D012008:Recurrence