Ethyl cyanoacetate: a new cyanating agent for the palladium-catalyzed cyanation of aryl halides.
A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Shanghai 201203, P. R. China, and Basilea Pharmaceutica China Ltd. , Haimen, Jiangsu 226100, P. R. China.
Shuyan
S
Zheng
Chunhui
C
Yu
Zhengwu
Z
Shen
D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000085:Acetates; D006846:Hydrocarbons, Halogenated; D010165:Palladium; C007659:ethyl cyanoacetate