[Evaluation of arterial elasticity in initial hypertension by pulse wave velocity and wave intensity technique].
OBJECTIVE
To explore the early changes of arterial elasticity in initial hypertension through two different methods.


METHODS
A total of 76 hypertensive patients (Grade 1-2, n = 32) were assigned into hypertension group while the age and gender-matched healthy population was selected as normal group (n = 44). All of them were monitored for baPWV in right carotid artery by wave intensity technique. The parameters of two methods were compared between two groups.


RESULTS
Higher bi-lateral baPWV were found in the hypertension group (right: (1472 ± 198) m/s vs (1353 ± 233) m/s), (left: (1465 ± 198) m/s vs (1353 ± 241) m/s) (P < 0.05). Compared with the normal group, Patients in the hypertension group had statistically higher W(1) ((9.8 ± 3.8)×10(3) mm Hg×m×s(-3) vs (7.4 ± 2.4)×10(3)) mm Hg×m×s(-3), W(2) ((2.8 ± 1.1)×10(3) mm Hg×m×s(-3) vs (2.0 ± 1.0)×10(3) mm Hg×m×s(-3)), stiffness parameter (β) ((6.9 ± 2.6) vs (5.1 ± 1.3)), pressure-strain elastic modulus (Ep) ((99 ± 39) kPa vs (57 ± 17) kPa), one-point wave velocity (PWVβ) ((6.0 ± 1.1) m/s vs (4.6 ± 0.6) m/s), PWVWI ((6.2 ± 1.4) m/s vs (4.4 ± 1.0) m/s) (P < 0.01). R-W(1) ((100 ± 14) ms vs (103 ± 13) ms), (W(1)-W(2)) ((261 ± 20) ms vs (274 ± 15) ms) and arterial compliance (AC) ((0.8 ± 0.4) mm(2)/kPa vs (1.1 ± 0.3) mm(2)/kPa) in the hypertension group were statistically lower than those of the normal group (P < 0.05).


CONCLUSIONS
The initial hypertensive patients may have impaired arterial elasticity during an early stage.
Department of Cardiology, Peking University Third Hospital & Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
Ying
Y
Nie
Bao-xia
BX
Chen
Xin-heng
XH
Feng
Zhao-ping
ZP
Li
Yang
Y
Yu
Jie
J
Yu
Ming
M
Xu
Wei
W
Gao
D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D016022:Case-Control Studies; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness; D055815:Young Adult