Axis formation: microtubules push in the right direction.
Live imaging reveals that the Drosophila oocyte nucleus is pushed by growing microtubules to break the radial symmetry of the oocyte and establish dorsoventral polarity.
Institute of Developmental Biology, Biocenter, University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany. siegfried.roth@uni-koeln.de
Siegfried
S
Roth
Jeremy
J
Lynch
D000818:Animals; D019521:Body Patterning; D002467:Cell Nucleus / Q000378:metabolism*; D016764:Cell Polarity; D004330:Drosophila / Q000166:cytology / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000502:physiology*; D009865:Oocytes / Q000166:cytology* / Q000502:physiology*; D010053:Ovary / Q000166:cytology; D016211:Transforming Growth Factor alpha / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D016211:Transforming Growth Factor alpha; C083730:grk protein, Drosophila; D038362:Glycogen Synthase Kinase 3; C472496:Par-1 protein, Drosophila