Ischemic postconditioning and size of myocardial infarction during inhibition of norepinephrine reuptake.
We studied the effect of inhibition of norepinephrine reuptake during the reperfusion period on the size of infarction zone after focal myocardial ischemia and under conditions of ischemic postconditioning. In groups 1 and 2, 30-min occlusion of the left coronary artery followed by 120-min reperfusion was performed. In groups 3 and 4, ischemia was followed by ischemic postconditioning (six 10-sec occlusions alternating with 10-sec reperfusions). Ringer solution (1 ml, groups 1 and 3) and desipramine (0.8 mg/kg, groups 2 and 4) were injected intravenously at the beginning of reperfusion. The area of myocardial infarction in group 1 was 32.0±3.1% of the area of the risk zone; in groups 2, 3, and 4 the corresponding value was 46.1±3.4% (p=0.006), 22.2±2.6% (p=0.028), and 50.3±3.1% (p=0.018), respectively. It was shown that inhibition of norepinephrine reuptake in the early reperfusion period after ischemia increased myocardial injury and abolished the protective effect of ischemic postconditioning.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. NSE2@mail.ru
S E
SE
Naumenko
T V
TV
Latysheva
M A
MA
Gilinsky
D000818:Animals; D057775:Ischemic Postconditioning; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D009638:Norepinephrine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D009638:Norepinephrine