Effect of L-arginine, vitamin B6 and folic acid on parameters of endothelial dysfunction and microcirculation in the placenta in modeling of L-NAME-induced NO deficiency.
L-arginine (200 mg/kg), vitamin B(6) (2 mg/kg), and folic acid (0.2 mg/kg) exert a protective effect on endothelial function in L-NAME-induced NO deficiency in male and pregnant female Wistar rats. Combined administration of these agents effectively prevented the development of endothelial dysfunction and L-NAME-induced preeclampsia.
Kursk State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Kursk, Russia. mkorokin@mail.ru
M V
MV
Korokin
M V
MV
Pokrovsky
O O
OO
Novikov
V V
VV
Gureev
T A
TA
Denisyuk
L V
LV
Korokina
O S
OS
Polyanskaya
V A
VA
Ragulina
T G
TG
Pokrovskaya
L M
LM
Danilenko
A S
AS
Belous
D000818:Animals; D001120:Arginine / Q000494:pharmacology* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005492:Folic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000172:deficiency*; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D025101:Vitamin B 6 / Q000494:pharmacology* / Q000627:therapeutic use
D009569:Nitric Oxide; D025101:Vitamin B 6; D005492:Folic Acid; D001120:Arginine; D052250:Nitric Oxide Synthase Type III; D019331:NG-Nitroarginine Methyl Ester