Liquid viruses by nanoscale engineering of capsid surfaces.
Surface engineering of plant virus capsids via cationization (1) and stoichiometric coupling of a polymer surfactant coronal layer (2) produces a highly concentrated, solvent-free liquid virus at 28 °C. These ionic bionanoconstructs are viscoelastic, retain plant infectivity and can be dispersed in a range of organic solvents for aerosol delivery.
Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Avinash J
AJ
Patil
Nina
N
McGrath
J Elaine
JE
Barclay
David J
DJ
Evans
Helmut
H
Cölfen
Ian
I
Manners
Adam W
AW
Perriman
Stephen
S
Mann
D002213:Capsid / Q000737:chemistry*; D017798:Comovirus / Q000737:chemistry* / Q000502:physiology; D004738:Engineering / Q000379:methods*; D007887:Fabaceae / Q000821:virology; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods*; D061848:Optical Imaging; D011487:Protein Conformation; D013499:Surface Properties