Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.
A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF(3)-containing building blocks from simple starting materials.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Rong
R
Zhu
Stephen L
SL
Buchwald
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D008745:Methylation; D010084:Oxidation-Reduction
D000475:Alkenes; D003300:Copper