[Research progress of liver X receptor agonists].
Liver X receptor (LXR), a member of the superfamily of nuclear receptors, plays an important role in the activation of transcription factors involved in cholesterol metabolism, glucose homeostasis inflammation and lipogenesis. It is shown that LXR agnoists have the potentiality to be used as drugs for the prevention and treatment of atherosclerosis, which is its best investigated therapeutic indication. There are many compounds being studied in preclinical evaluation and biological assay. This paper will review briefly the LXR agonists in recent years.
Department of Chemistry, Capital Normal University, Beijing 100048, China.
Yu
Y
Liang
Chang-Bin
CB
Guo
Chong
C
Zhang
Zhen-Geng
ZG
Hou
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000031:analogs & derivatives / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D050356:Lipid Metabolism; D050155:Lipogenesis; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000819:agonists* / Q000502:physiology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D000588:Amines; D001562:Benzimidazoles; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D011804:Quinolines; D051780:Sterol Regulatory Element Binding Protein 1; C028358:24,25-epoxycholesterol; D002784:Cholesterol; D005947:Glucose