Disorders in the secretory cycle of follicular thyrocytes and their correction with thyrotropic hormone in experimental non-thyroidal illness syndrome.
The influence of LPS on the thyroid gland leads to more intensive synthesis and release of thyroglobulin into the follicle lumen and inhibition of its resorption and proteolysis, which reduces the production of thyroxine. Treatment with thyroid-stimulating hormone normalizing the secretory processes in the follicular thyrocytes is a pathogenetically justified method for correction of non-thyroidal illness syndrome in acute endotoxicosis.
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. yaglova@mail.ru
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D000818:Animals; D005067:Euthyroid Sick Syndromes / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013954:Thyroglobulin / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism*; D013972:Thyrotropin / Q000627:therapeutic use; D013974:Thyroxine / Q000378:metabolism
D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine