Experimental study of cytoprotective effect of melatonin in radiation exposure.
The effects of a synthetic analog of melatonin in doses of 10 and 50 mg/kg on the incidence of chromosome aberrations in bone marrow cells was studied in outbred rats exposed to single short-term γ-irradiation in doses of 2 and 4 Gy. Melatonin injected 30 min before the exposure 2-fold reduced the incidence of chromosome aberrations. Possible mechanisms of anticlastogenic effect of melatonin are discussed.
S. M. Kirov Military Medical Academy, St. Petersburg, Russia. pikalova_lidiya@mail.ru
L V
LV
Pikalova
V I
VI
Legeza
M B
MB
Ivanov
E B
EB
Zhakovko
D000818:Animals; D021461:Animals, Outbred Strains; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D019610:Cytoprotection; D005260:Female; D008550:Melatonin / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D008550:Melatonin