Copper-catalyzed sequential Ullmann N-arylation and aerobic oxidative C-H amination: a convenient route to indolo[1,2-c]quinazoline derivatives.
An efficient synthesis of indolo[1,2-c]quinazoline derivatives has been developed by copper-catalyzed sequential Ullmann N-arylation and aerobic oxidative C-H amination. The protocol uses readily available 2-(2-halophenyl)-1H-indoles and (aryl)methanamines as the starting materials to afford indolo[1,2-c]quinazolines, which are the core units of hinckdentine A.
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Peng
P
Sang
Yongju
Y
Xie
Jianwei
J
Zou
Yuhong
Y
Zhang
D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry
D007211:Indoles; D011799:Quinazolines; C485801:hinckdentine A; D003300:Copper