Metformin associated B12 deficiency.
According to the ADA guidelines, metformin and lifestyle modifications are the first line therapies in the treatment of type 2 diabetes mellitus. Metformin does, however, cause vitamin B-12 malabsorption, which may increase the risk of developing vitamin B-12 deficiency--a clinically important and treatable condition. Here we report a case of 60 year old diabetic male presenting with clinical features of Vitamin B-12 deficiency on long term metformin therapy, which was confirmed on investigations. Patient showed symptomatic improvement with change in treatment.
Sumati Diabetes Clinic, Nashik 422002.
Anand Ajit
AA
Kumthekar
Hitesh Vinod
HV
Gidwani
Ajit Bhaskar
AB
Kumthekar
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008286:Malabsorption Syndromes / Q000139:chemically induced; D008297:Male; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014803:Vitamin B Complex / Q000627:therapeutic use
D007004:Hypoglycemic Agents; D014803:Vitamin B Complex; D008687:Metformin; D014805:Vitamin B 12; D006879:Hydroxocobalamin