A new era of GPCR structural and chemical biology.
G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Sébastien
S
Granier
Brian
B
Kobilka
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D003461:Crystallography; D055808:Drug Discovery; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D055550:Protein Stability; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction
D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins