Effect of lysophosphatidylcholine on α-adrenoreactivity of rat aorta smooth muscles.
In experiments on rat aortic ring segments, lysophosphatidylcholine in concentrations of 2×10(-6), 2×10(-5), and 2×10(-4) M did not suppress the tonotropic effect of phenylephrine (6×10(-6) and 6×10(-5) M) and in concentration of 2×10(-5) M even potentiated it, which was noted for phenylephrine at a concentration of 6×10(-6) M. It was concluded that the chemomodulating effect of lysophosphatidylcholine depends on the type of receptors and cells.
Department of Normal Physiology, Kirov State Medical Aacdemy, Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia.
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EO
Samodelkina
V I
VI
Tsirkin
N V
NV
Prokazova
D058646:Adrenergic alpha-1 Receptor Agonists / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004357:Drug Synergism; D066298:In Vitro Techniques; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D018709:Statistics, Nonparametric; D014661:Vasoconstriction / Q000187:drug effects
D058646:Adrenergic alpha-1 Receptor Agonists; D008244:Lysophosphatidylcholines; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine