Effect of antibodies to glutamate on the content of neurotransmitter amino acids in brain structures of rats with ischemic damage to the prefrontal cortex.
Experiments on the model of bilateral photothrombosis in the prefrontal cortex showed that antibodies to glutamate administered intranasally 1 h after ischemic damage to the brain cortex led to a decrease in glutamate content in the hippocampus and prefrontal cortex and had no effect on aspartate concentration in these structures of the brain.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. romanovaga@mail.ru
G A
GA
Romanova
Yu N
YN
Kvashennikova
F M
FM
Shakova
T V
TV
Davydova
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D018698:Glutamic Acid / Q000276:immunology*; D020767:Intracranial Thrombosis / Q000188:drug therapy; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D051381:Rats
D000596:Amino Acids; D000906:Antibodies; D018377:Neurotransmitter Agents; D018698:Glutamic Acid