Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression.
Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846G/A) genotype and rapid cirrhosis development and indicate the necessity of studying the mechanisms underlying this association.
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
D L
DL
Nepomnyashchikh
V A
VA
Vavilin
S V
SV
Aidagulova
S I
SI
Makarova
Yu Yu
YY
Karavaeva
E G
EG
Shchepotina
O A
OA
Postnikova
Zh V
ZhV
Nokhrina
E V
EV
Vinogradova
V V
VV
Lyakhovich
D000328:Adult; D000368:Aged; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016174:Hepacivirus / Q000502:physiology; D006509:Hepatitis B / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology; D006526:Hepatitis C / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000821:virology; D006519:Hepatitis, Alcoholic / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012800:Siberia; D044465:White People
D005819:Genetic Markers; D019389:Cytochrome P-450 CYP2D6