A new rat model of reversible global cerebral ischemia.
A new rat model of global cerebral ischemia-reperfusion was proposed via reversible occlusion of the major vessels originating from the aortic arch and supplying the brain. This technique can be used for the search and study of exogenous (pharmacological) and endogenous methods of brain protection from ischemia-reperfusion injury.
V. A. Almazov Federal Center of the Heart, Blood, and Endocrinology, St. Petersburg, Russia. ShcherbakNS@yandex.ru
N S
NS
Shcherbak
M M
MM
Galagudza
A N
AN
Kuzmenkov
D A
DA
Ovchinnikov
L B
LB
Mitrofanova
E R
ER
Barantsevich
E V
EV
Shlyakhto
D000818:Animals; D001011:Aorta / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology; D002339:Carotid Arteries / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006651:Histocytochemistry; D008026:Ligation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology; D015996:Survival Rate