Coccidioidomycosis infection of a total knee arthroplasty in a nonendemic region.
Fungal prosthetic joint infections are rare and difficult to treat. There is an ongoing discussion about the type and duration of antifungal treatment and the necessity of prosthesis removal. We report the first European case of an infected total knee arthroplasty with Coccidioides immitis. Treatment consisted of lifelong treatment with oral fluconazole at a dose of 400 mg/d, without total knee arthroplasty removal. After 6 months, the initial complaints of pain and swelling were completely resolved. This case report clearly states that a travel history and culturing for fungi are helpful in patients with persisting complaints after joint arthroplasty.
Department of Orthopaedic Surgery, St. Anna Hospital, P.O. Box 90, 5664 EH Geldrop, The Netherlands.
Shennah
S
Austen
Walter
W
van der Weegen
Cees M
CM
Verduin
Marc
M
van der Valk
Henk J
HJ
Hoekstra
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D003045:Coccidioides; D003047:Coccidioidomycosis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D014195:Travel
D000935:Antifungal Agents; D015725:Fluconazole