[A new technique for local immunotherapy of allergic rhinosinusitis--intranasal aerosol therapy with the use of a cycloferon solution].
The objective of this study was to estimate the clinical and immunological efficacy of local immunotherapy with the use of a cycloferon solution. The authors describe a new highly efficacious method for the treatment of allergic rhinosinusitis by means of the intranasal introduction of the cycloferon aerosol (125 mg/ml). A total of 79 patients presenting with this pathology were included in the study. Comparative evaluation of clinical and immunological efficiency of intranasal aerosol therapy using the cycloferon solution and its standard parenteral administration has demonstrated the high efficiency and safety of intranasal aerosol therapy in a group of immunocompromised patients with allergic rhinosinusitis. The study revealed correlation between clinical symptoms and characteristics of the patients' cytokine status which suggests the high informative value of measuring principle cytokine levels and especially their local fractions.
N S
NS
Tataurshchikova
I G
IG
Sidorovich
D000166:Acridines / Q000008:administration & dosage*; D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007167:Immunotherapy; D008297:Male; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000188:drug therapy*; D012852:Sinusitis / Q000097:blood / Q000188:drug therapy*; D055815:Young Adult
D000166:Acridines; D000336:Aerosols; D000893:Anti-Inflammatory Agents; D016207:Cytokines; C026430:10-carboxymethyl-9-acridanone