Temporal lobe epilepsy in a cat with a pyriform lobe oligodendroglioma and hippocampal necrosis.
A 14-year-old male domestic shorthair cat presented with an acute onset of aggressive behaviour, fear and hypersalivation. Neurological examination revealed bilateral mydriasis and left-sided facial twitching and hemiparesis. Magnetic resonance imaging (MRI) showed moderate bilateral symmetrical T2-hyperintensity along the entire hippocampus and bilateral asymmetric T2-hyperintensity in the pyriform lobes. Marked bilateral contrast enhancement of the hippocampus was evident on post-contrast T1-weighted images. The partial complex seizures were refractory to medical treatment and the cat was euthanased 4 days after admission. The clinical and MRI findings were consistent with feline hippocampal necrosis (FHN). On histopathology, neuronal necrosis and astrocytosis were present in the hippocampi and pyriform lobes. In addition, an oligodendroglioma was detected in the right pyriform lobe. Contrary to previous reports of FHN in which no underlying cause could be identified, we believe that in this case the seizure focus arose from a neoplastic lesion within the right pyriform lobe. This unique case report represents the so-called 'dual pathology' of temporal lobe epilepsy in humans, in which an extrahippocampal lesion within the temporal lobe results in hippocampal sclerosis.
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. av354@cam.ac.uk
An E
AE
Vanhaesebrouck
Barbara
B
Posch
Sam
S
Baker
Ioannis N
IN
Plessas
Anthony C
AC
Palmer
Fernando
F
Constantino-Casas
D000818:Animals; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology* / Q000601:surgery*; D002415:Cats; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009336:Necrosis / Q000662:veterinary; D009837:Oligodendroglioma / Q000150:complications / Q000473:pathology / Q000662:veterinary*