Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation.
Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements. These transgenic animals overexpress HO-1 in basal conditions but maintain HO-1 inducibility, protecting the kidney against glycerol- and cisplatin-induced nephrotoxicity.
Department of Physiology, Faculty of Medicine, University of Murcia, Murcia, Spain. mgsalom@um.es
Miguel G
MG
Salom
Bárbara
B
Bonacasa
D000818:Animals; D005260:Female; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D011247:Pregnancy
C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1