Structure determination of two new trichothecenes from a halotolerant fungus Myrothecium sp. GS-17 by NMR spectroscopy.
Two new trichothecenes, named 8α-hydroxyroridin H and myrothecin A, along with six known compounds, 8α-acetoxy roridin H, isororidin K, verrucarin A, verrucarin J, verrucarin L and 8α-acetoxy verrucarin L, were isolated from the fermentation broth of a halotolerant fungus Myrothecium sp. GS-17, which was separated from the soil sample of a salina. Structure elucidation and NMR signal assignments were achieved on the basis of spectroscopy. In addition, compounds 1 and 2 were active against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Song-Ya
SY
Zhang
Zhan-Lin
ZL
Li
Li-Ping
LP
Guan
Xin
X
Wu
Hua-Qi
HQ
Pan
Jiao
J
Bai
Hui-Ming
HM
Hua
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D006999:Hypocreales / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012232:Rhizoctonia / Q000187:drug effects; D013329:Structure-Activity Relationship; D014255:Trichothecenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C579417:8alpha-hydroxyroridin H; D000935:Antifungal Agents; D014255:Trichothecenes; C579418:myrothecin A