Hypoglycemic effects of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron beam synthesis nanotechnology.
Hypoglycemic effect of hyaluronate-endo-β-N-acetylhexosaminidase immobilized by electron-beam synthesis nanotechnology (imHEA-HA) was studied in experimental insulin-dependent and insulin-independent diabetes mellitus. The drug exhibited a hypoglycemic effect of its own and potentiated the pharmacological effect of exogenous insulin injected in vivo. Studies on liver cell culture demonstrated an increase of cell sensitivity to insulin after treatment with imHEA-HA.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
A M
AM
Dygai
G N
GN
Zyuz'kov
V V
VV
Zhdanov
E V
EV
Udut
L A
LA
Miroshnichenko
T J
TJ
Khrichkova
E V
EV
Simanina
L A
LA
Stavrova
R V
RV
Gurto
M Yu
MY
Minakova
A V
AV
Chajkovskij
T S
TS
Markova
A V
AV
Artamonov
A A
AA
Bekarev
P G
PG
Madonov
D N
DN
Kinsht
D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy; D004800:Enzymes, Immobilized / Q000627:therapeutic use*; D006025:Glycosaminoglycans / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D036103:Nanotechnology / Q000379:methods*; D001619:beta-N-Acetylhexosaminidases / Q000737:chemistry* / Q000627:therapeutic use*
D004800:Enzymes, Immobilized; D006025:Glycosaminoglycans; D007004:Hypoglycemic Agents; D006821:Hyaluronoglucosaminidase; D001619:beta-N-Acetylhexosaminidases