MYC rearrangement involving a novel non-immunoglobulin chromosomal locus in precursor B-cell acute lymphoblastic leukemia.
MYC rearrangement, a characteristic cytogenetic abnormality of Burkitt lymphoma and several subsets of other mature B-cell neoplasms, typically involves an immunoglobulin gene partner. Herein, we describe a case of precursor B-cell lymphoblastic leukemia harboring a MYC rearrangement with a novel non-immunoglobulin partner locus. The patient was a 4-yr-old Korean boy with ALL of the precursor B-cell immunophenotype. At the time of the second relapse, cytogenetic analyses revealed t(4;8)(q31.1;q24.1) as a clonal evolution. The MYC rearrangement was confirmed by FISH analysis. He died 3 months after the second relapse without achieving complete remission. To our knowledge, this is the first report of a case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell lymphoblastic leukemia.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ja-Young
JY
Seo
Soo Hyun
SH
Lee
Hee-Jin
HJ
Kim
Keon Hee
KH
Yoo
Hong Hoe
HH
Koo
Yong Gon
YG
Cho
Sam Im
SI
Choi
Sun-Hee
SH
Kim
D001854:Bone Marrow Cells / Q000473:pathology; D002675:Child, Preschool; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D056426:Genetic Loci; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007621:Karyotyping; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012008:Recurrence; D014178:Translocation, Genetic
D007136:Immunoglobulins; D016271:Proto-Oncogene Proteins c-myc