"Inflammatory response to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass".
"Cardiac surgery with cardiopulmonary bypass (CPB) induces a systemic inflammatory response syndrome that may contribute to postoperative morbidity and mortality.  We investigated the in-flammatory responses to colloids compared to crystalloid priming in cardiac surgery patients with cardiopulmonary bypass.  Thirty patients undergoing coronary artery bypass grafting (CABG) preparing for CPB were randomized into Ringer's solution (RS), 10% hydroxyethyl starch (HES) or 25% human albumin (HA) group.  Serum concentrations of tumor necrosis factor-α  (TNF-α), interleukin-1 β   (IL-1β ), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured before CPB, at the end of CPB and 1, 6 and 12 h after CPB.  Serum C-reactive protein (CRP) was determined pre-operatively and then daily for 2 days. Body-weight gain was significantly decreased on the day after surgery in the HES group than in the RS group.  Volume priming in CPB for CABG patients using HA or HES preparation had less tendency for intense inflammatory response with lower levels of TNF-α, IL-1 β , IL-6 and higher levels of IL-10 compared to patients treated with RS.  HES prime had lower levels of circulating CRP than in patients treated with HA or Ringer prime on the second post-operative day.  Our data indicate that volume priming using colloid during CPB in CABG patients might exert beneficial effects on inflammatory responses."
Department of Nursing, Taipei Veterans General Hospital, Taipei 11217, Taiwan, Republic of China.
Huey-Ling
HL
Liou
Chun-Che
CC
Shih
Yann-Fen C
YF
Chao
Nien-Tsung
NT
Lin
Shau-Ting
ST
Lai
Shu-Hua
SH
Wang
Hsing I
HI
Chen
D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D003102:Colloids; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D053583:Interleukin-1beta
D003102:Colloids; D006895:Hydroxyethyl Starch Derivatives; D053583:Interleukin-1beta