[Sirtuin1 and lung disease].
Sirtuin1 (Sirt1) is a NAD-dependent class III histone deacetylase (HDAC), and regulates pulmonary immune/inflammatory system and the aging process mainly through post-translational modification. Sirt1 could become a potential target for treatment of lung diseases due to participating in the development of a variety of lung diseases. In this paper, physiological characteristics, biological activities, modification regulations and its relationship with chronic obstructive pulmonary emphysema, asthma and lung cancer are reviewed.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Ji
J
Shi
Ai-Min
AM
Meng
Qi
Q
Hou
D000818:Animals; D001249:Asthma / Q000378:metabolism; D001549:Benzamides / Q000494:pharmacology; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism; D009284:Naphthols / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology
D001549:Benzamides; D009284:Naphthols; D013267:Stilbenes; C439060:sirtinol; D056564:Sirtuin 1; D000077185:Resveratrol