Isolated necrotizing myopathy associated with ANTI-PL12 antibody.
BACKGROUND
Immune-mediated myopathies are a heterogeneous group of chronic autoimmune disorders. Autoantibodies associated with this disease complex are classified into myositis-associated and myositis-specific. Anti-tRNA synthetase antibodies are the most well known of the myositis-specific antibodies. Previous reports have revealed an association of tRNA synthetase autoantibodies with systemic connective tissue disorders.


METHODS
Our case report involved a 49-year-old man who developed difficulty walking and climbing stairs 5 months prior to his initial visit. No rash or skin changes were observed.


RESULTS
Laboratory testing was positive for anti-PL12 autoantibody with a negative evaluation for connective tissue disorder (CTD). The patient was found to have necrotizing myopathy associated with anti-PL12 antibodies in the absence of inflammatory changes on biopsy, significant derangement of muscle enzymes, or findings characteristic of a typical CTD.


CONCLUSIONS
A high index of suspicion must be maintained for immune-mediated necrotizing myopathy despite the absence of an identifiable CTD and milder symptoms.
Department of Neurology, University Hospitals Case Medical Center, Bolwell Fifth Floor, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA. prachi.mechndiratta@gmail.com
Prachi
P
Mehndiratta
Sonal
S
Mehta
Sunil V
SV
Manjila
Gary M
GM
Kammer
Mark L
ML
Cohen
David C
DC
Preston
D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies