Sensitizing cancer cells: is it really all about U?
In this issue of Cancer Cell, Hu et al. report that TMPK and RNR, two key enzymes in deoxyribonucleotide biosynthesis, co-localize to damaged DNA and produce nucleotides necessary for DNA repair while suppressing uracil incorporation. TMPK inhibition disrupts this balance and selectively sensitizes cancer cells to low-dose chemotherapy.
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA. pjs13@cornell.edu
Patrick J
PJ
Stover
Robert S
RS
Weiss