Antioxidant properties of β-seleno amines against lipid peroxidation in rat brain and liver.
β-Seleno amines were screened for in vitro antioxidant activity. The compounds (C1-C4) were tested against lipid peroxidation induced by iron and sodium nitroprusside in rat brain and liver homogenates. The compounds showed inhibition against thiobarbituric acid reactive species (TBARS) induced by different pro-oxidants (10μM FeSO(4) and 5μM sodium nitroprusside (SNP) in rat brain and liver homogenates. The compounds exhibited strong antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and phosphomolybdenum assays. The IC(50) values revealed that the β-seleno amines in which the amino group was protected with protecting groups tert-butyloxycarbonyl (Boc) and Tosyl (Ts) groups showed better antioxidant profiles compared to the free monoselenides. The total antioxidant activity of C1, C2, C3 and C4 were found to be 85.2±11.5, 114±7.9, 138±8.5, 125.81±5.2μM/ml of ascorbic acid respectively. Therefore, these compounds may be used as synthetic antioxidants.
Department of Eastern Medicine and Surgery, University of the Pooch Rawalakot Azad Kashmir Pakistan. Electronic address: mubashersabir@yahoo.com.
S M
SM
Sabir
Department of Chemistry, Abdul Wali Khan University Mardan, Khyber pakhtunkhwa, Pakistan.
Syed M
SM
Salman
Departmento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, Brazil.
J B T
JBT
Rocha
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005296:Ferrous Compounds; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009599:Nitroprusside; D016566:Organoselenium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000588:Amines; D000975:Antioxidants; D005296:Ferrous Compounds; D016566:Organoselenium Compounds; D017392:Thiobarbituric Acid Reactive Substances; D009599:Nitroprusside; C020748:ferrous sulfate