Iron-dependent synthesis of hemolysins by Staphylococcus aureus.
We studied the effect of Fe(2+) on hemolysin synthesis by Staphylococcus aureus. Hemolytic activity of staphylococci was shown to be iron-dependent. Addition of Fe(2+) to the nutrient medium induced the synthesis of α-hemolysin by staphylococci. Increasing the concentration of Fe(2+) was followed by an increase in hemolytic activity of staphylococci. Inducible synthesis of α-hemolysin probably serves as an important pathogenetic factor in the development of staphylococcal infection in patients with excessive iron accumulation in the body.
Department of Chemistry, Yugorsk State University, Khanty-Mansiysk, Russia. leonovvadim@yandex.ru
V V
VV
Leonov
V V
VV
Kosterina
V V
VV
Varnitsina
T Kh
TKh
Timokhina
N A
NA
Kurlovich
D002478:Cells, Cultured; D006460:Hemolysin Proteins / Q000378:metabolism*; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000378:metabolism*
D006460:Hemolysin Proteins; D007501:Iron