Indomethacin induction of metamorphosis from the asexual stage to sexual stage in the moon jellyfish, Aurelia aurita.
We found while screening a chemical library that indomethacin, an inhibitor of prostaglandin biosynthesis, induced strobilation (metamorphosis from the asexual to sexual stage) in the moon jellyfish, Aurelia aurita. Indomethacin initiated strobilation in a dose-dependent manner, but was not involved in the progression of strobilation. Pharmacological experiments suggested that indomethacin could induce strobilation independently of prostaglandin biosynthesis.
Faculty of Applied Biological Science, Graduate School of Biosphere Science, Hiroshima University, Higashi-hiroshima, Hiroshima, Japan. hkuni@hiroshima-u.ac.jp
Hisato
H
Kuniyoshi
Izumi
I
Okumura
Rie
R
Kuroda
Natsumi
N
Tsujita
Kenji
K
Arakawa
Jun
J
Shoji
Tamio
T
Saito
Hiroyuki
H
Osada
D000818:Animals; D004305:Dose-Response Relationship, Drug; D057166:High-Throughput Screening Assays; D007213:Indomethacin / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects* / Q000502:physiology; D008675:Metamorphosis, Biological / Q000187:drug effects* / Q000502:physiology; D011453:Prostaglandins / Q000378:metabolism; D037401:Scyphozoa / Q000187:drug effects* / Q000502:physiology; D054852:Small Molecule Libraries / Q000494:pharmacology
D011453:Prostaglandins; D054852:Small Molecule Libraries; D007213:Indomethacin