Chemical speciation of nanoparticles surrounding metal-on-metal hips.
Spectromicroscopy of tissue surrounding failed CoCr metal-on-metal hip replacements detected corroded nanoscale debris in periprosthetic tissue in two chemical states, with concomitant mitochondrial damage. The majority of debris contained Cr(3+), with trace amounts of oxidised cobalt. A minority phase containing a core of metallic chromium and cobalt was also observed.
Department of Materials, Imperial College London, London, UK.
Angela E
AE
Goode
James M
JM
Perkins
Ann
A
Sandison
Chithra
C
Karunakaran
Huikai
H
Cheng
David
D
Wall
John A
JA
Skinner
Alister J
AJ
Hart
Alexandra E
AE
Porter
David W
DW
McComb
Mary P
MP
Ryan
D002857:Chromium / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D006622:Hip Prosthesis; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011475:Prosthesis Failure
D002857:Chromium; D003035:Cobalt