Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins.
Geroprotective peptide T-34 regulates the expression of mRNA for various genes. The development of gastric ulcer is associated with morphological and molecular changes resulting from modulation of the synthesis of antioxidant and anti-inflammatory proteins. Peptide T-34 normalizes the synthesis of these proteins by regulating the expression of the corresponding genes.
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
V Kh
VKh
Khavinson
N S
NS
Lin'kova
A V
AV
Dudkov
V O
VO
Polyakova
I M
IM
Kvetnoi
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage; D003538:Cystamine / Q000008:administration & dosage; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D016480:Helicobacter pylori / Q000254:growth & development; D008297:Male; D052248:Nitric Oxide Synthase Type I / Q000235:genetics / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000382:microbiology; D051996:Transcription Factor RelA / Q000235:genetics / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D018840:HSP70 Heat-Shock Proteins; D009842:Oligopeptides; D012333:RNA, Messenger; D051996:Transcription Factor RelA; C026740:glutamyl-aspartyl-glycine; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D017291:Clarithromycin; D003538:Cystamine