Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies.
Glycopeptide antibiotic derivative teicoplanin ψ-aglycone has been bound covalently to a fullerenopyrrolidine derivative using azide-alkyne 1,3-dipolar cycloaddition reaction. The aggregation of the antibiotic-fullerene conjugate in aqueous solution has been studied. The conjugate exhibited antibacterial activity against enterococci resistant to teicoplanin.
Department of Pharmaceutical Chemistry, University of Debrecen, Medical and Health Science Center, Egyetem tér 1, H-4032 Debrecen, Hungary.
Szilvia
S
Tollas
Ilona
I
Bereczki
Attila
A
Sipos
Erzsébet
E
Rőth
Gyula
G
Batta
Lajos
L
Daróczi
Sándor
S
Kéki
Eszter
E
Ostorházi
Ferenc
F
Rozgonyi
Pál
P
Herczegh
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D037741:Fullerenes / Q000737:chemistry*; D017334:Teicoplanin / Q000031:analogs & derivatives* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D037741:Fullerenes; D017334:Teicoplanin; C063101:teicoplanin aglycone; C069837:fullerene C60