Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.
Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Natalia
N
Chernyak
Stephen L
SL
Buchwald
D000079:Acetaldehyde / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D005019:Ethyl Ethers / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*
D000814:Aniline Compounds; D005019:Ethyl Ethers; D006841:Hydrocarbons, Aromatic; C013333:ethyl vinyl ether; D000079:Acetaldehyde