[Effect of Yunnan Baiyao capsules on the socket healing of impacted mandibular third molar extraction].
OBJECTIVE
To investigate the effect of the traditional Chinese medicine Yunan Baiyao on the socket healing of impacted mandibular third molar extraction.


METHODS
A total of 200 patients requiring extractions of impacted mandibular wisdom teeth were randomized into the treatment group and the control group in a double-blinded manner, and Yunan Baiyao capsules or placebo capsules (2 g/d) were orally administered for 28 days after the operation. Dental quantitative CT scan was performed, and the volume and density of new bone at the extraction site were measured two month after operation.


RESULTS
A total of 188 patients completed the study. No adverse events related to the medication occurred. The volume of new bone was (477.39 ± 166.47) mm(3) in the treatment group and (442.65 ± 143.58) mm(3) in the control group, which was not significantly different between the two groups. The density of new bone was (296.90 ± 37.94) mg/cm(3) in the treatment group and (298.54 ± 40.21) mg/cm(3) in the control group, which was not significantly different between the two groups. The number of the teeth root, the impacted conditions, whether or not retainning the alveolar septum, suturing soft tissues of the extraction site and blood clot formation within 1 week after operation were significantly correlated with the volume of new bone.


CONCLUSIONS
Yunnan Baiyao capsules has no effect on the volume and density of new bone at the extraction site two months after operation following extractions of impacted mandibular third molars.
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Kai
K
Zhang
Xing
X
Wang
Wei
W
Zhang
Ji-zhi
JZ
Zhao
Hui
H
Dong
D000293:Adolescent; D000328:Adult; D001861:Bone Regeneration / Q000187:drug effects; D002214:Capsules; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D008517:Phytotherapy; D014081:Tooth Extraction / Q000009:adverse effects*; D020390:Tooth Socket / Q000187:drug effects; D014095:Tooth, Impacted / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
D002214:Capsules; D004365:Drugs, Chinese Herbal; C530960:yunnan baiyao