Positive inotropic effect of tyrosine, histidine, and tryptophan in experiments on isolated human myocardium.
Experiments on myocardial strips isolated from the right auricular myocardium of patients with heart failure showed that tyrosine, histidine, and tryptophan increased the amplitude of electrically stimulated contractions. The nature of this effect and clinical implications are discussed.
Vyatka State Humanities University, Vyatka, Russia.
K N
KN
Korotaeva
V I
VI
Tsirkin
V A
VA
Vyaznikov
D002316:Cardiotonic Agents / Q000494:pharmacology*; D005260:Female; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology*; D014443:Tyrosine / Q000494:pharmacology*
D002316:Cardiotonic Agents; D014443:Tyrosine; D006639:Histidine; D014364:Tryptophan