Aureolic acids from a marine-derived Streptomyces sp. WBF16.
A marine-derived actinomycete (Streptomyces sp. WBF16) exhibiting antitumor activities was investigated. The strain was identified using morphological, biochemical and genetic techniques. 16S rDNA sequence of the isolate indicated that it was most closely related to Streptomyces coelicolor A3 (2). Furthermore, a new aureolic acid (Chromomycin B, 1), along with Chromomycin A(2) (2) and Chromomycin A(3) (3) were isolated from its secondary metabolites. Their structures were determined by chemical and spectroscopic methods including 1D, 2D NMR and HRMS. Compounds 1-3 showed strong cytotoxicity against SGC7901, HepG2, A549, HCT116 and COC1 and HUVEC.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.
Jiansheng
J
Lu
Yihua
Y
Ma
Jianjia
J
Liang
Yingying
Y
Xing
Tao
T
Xi
Yuanyuan
Y
Lu
D002460:Cell Line; D045744:Cell Line, Tumor; D002865:Chromomycins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D045325:HCT116 Cells; D056945:Hep G2 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008386:Marine Biology; D008926:Plicamycin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D002865:Chromomycins; D008926:Plicamycin