Secretomics for skeletal muscle cells: a discovery of novel regulators?
Metabolic tissues, including skeletal muscle, adipose tissue and the digestive system, dynamically secrete various factors depending on the metabolic state, communicate with each other and orchestrate functions to maintain body homeostasis. Skeletal muscle secretes cytokines such as interleukin-6 (IL-6), IL-15, fibroblast growth factor-21 (FGF21) and IL-8. These compounds, myokines, play important roles in biological homeostasis such as energy metabolism, angiogenesis and myogenesis. New technological advances have allowed secretomics - analysis of the secretome - to be performed. The application of highly sensitive mass spectrometry makes qualitative and quantitative analysis of the secretome of skeletal muscle possible. Secretory proteins derived from skeletal muscle cells under various conditions were analyzed, and many important factors were suggested. In-depth studies of the secretome from metabolic cells in various conditions are strongly recommended. This study will provide information on methods of novel communication between metabolic tissues.
Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk 790-784, Republic of Korea.
Jong Hyuk
JH
Yoon
Jaeyoon
J
Kim
Parkyong
P
Song
Taehoon G
TG
Lee
Pann-Ghill
PG
Suh
Sung Ho
SH
Ryu
D000273:Adipose Tissue / Q000378:metabolism; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D002450:Cell Communication; D019295:Computational Biology; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D019409:Interleukin-15 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D013058:Mass Spectrometry; D024510:Muscle Development / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*
D043925:Angiogenesis Inducing Agents; D019409:Interleukin-15; D015850:Interleukin-6; D016209:Interleukin-8