Vincristine induced cranial neuropathy.
Neuropathy is a well known side effect of vincristine, however cranial nerve toxicities are reported less frequently which can involve any cranial nerve in mostly bilateral pattern. As many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction, the potential for misdiagnosis is high. Here, along with review of literature we describe three cases on vincristine who developed cranial neuropathy while on treatment.
Department of Medicine, Pt. B.D. Sharma PGIMS, Rohtak 124001.
Gaurav
G
Dixit
Atul
A
Dhingra
Diksha
D
Kaushal
D000293:Adolescent; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003389:Cranial Nerve Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D020258:Neurotoxicity Syndromes / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D011736:Pyridoxine / Q000627:therapeutic use; D016896:Treatment Outcome; D014750:Vincristine / Q000009:adverse effects*; D014803:Vitamin B Complex / Q000627:therapeutic use; D055815:Young Adult
D000972:Antineoplastic Agents, Phytogenic; D002800:Cholinesterase Inhibitors; D014803:Vitamin B Complex; D014750:Vincristine; D011736:Pyridoxine; D011729:Pyridostigmine Bromide