Two new oxysporone derivatives from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua.
Two new oxysporone derivatives, pestalrone A (1) and pestalrone B (2), along with two known structurally related compounds 3, 4, were from the fermentation broth of the endophytic plant fungus Pestalotiopsis karstenii isolated from stems of Camellia sasanqua. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and comparison of chemical shifts with related known compounds. Compound 2 exhibited significant activities agains HeLa, HepG2 and U-251 with IC₅₀ values of 12.6, 31.7 and 5.4 µg/mL, respectively.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China. duqiangluo@163.com
Du Qiang
du Q
Luo
Lei
L
Zhang
Bao Zhong
BZ
Shi
Xiao Mei
XM
Song
D028244:Camellia / Q000382:microbiology; D049109:Cell Proliferation / Q000187:drug effects; D005658:Fungi / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000382:microbiology; D011753:Pyrones / Q000138:chemical synthesis / Q000737:chemistry; D013057:Spectrum Analysis
D011753:Pyrones; C577057:pestalrone A; C577058:pestalrone B