Method for activation and recycling of trityl resins.
This note describes a rapid and mild strategy for the loading of alcohols and anilines onto a polystyrene triphenylmethyl (trityl) resin. High loadings were obtained in a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate followed by alcohols or anilines. Yields were comparable or better than known literature methods. Recycling of the recovered resin was also possible using the developed method.
Department of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, SE-41296 Göteborg, Sweden.
Itedale Namro
IN
Redwan
Morten
M
Grøtli
D000438:Alcohols / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D017743:Equipment Reuse; D011137:Polystyrenes / Q000737:chemistry*; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D000438:Alcohols; D000814:Aniline Compounds; D001881:Borates; D011137:Polystyrenes; D014320:Triphenylmethyl Compounds; C003723:trityl chloride; C005142:triethyloxonium tetrafluoroborate