Bioavailability of chromium(III)-supplements in rats and humans.
Chromium(III) is long regarded as essential trace element but the biochemical function and even basic transport ways in the body are still unclear. For a more rational discussion on beneficial as well as toxic effects of Cr(III), we re-investigated the bioavailability of the most important oral Cr supplements by using radiolabeled compounds and whole-body-counting in rats and in the first time also in humans. The apparent absorption of (51)Cr(III) from Cr-picolinate, Cr-nicotinate, Cr-phenylalaninate, Cr-proprionate, or Cr-chloride was generally low (0.04-0.24 %) in rats with slightly higher values for Cr-chloride and -phenylalaninate. Taking a fast urine excretion into account, the true absorption of (51)Cr was clearly higher for CrPic(3) (0.99 %), probably indicating a different uptake mechanism of this rather stable organic Cr complex. The bioavailability of CrPic(3) and Cr(D: -Phen)(3), the leading compounds in actual investigations, was analysed also in human volunteer by intraindividual comparison. The apparent absorption (=Cr bioavailability) of (51)Cr from both compounds was substantially higher in humans (0.8-1 %) than in rats. Again, most of freshly absorbed CrPic(3) was excreted into the urine resulting in the same low whole-body retention after 7 days for both compounds. In summary, the bioavailability of Cr from pharmaceutical Cr compound is lower than hitherto assumed. Importantly, humans absorb Cr(III) clearly better than rats. The absorption mechanism of CrPic(3) seems to be different from ionic Cr(III) but, as only the same low amount of Cr is retained from this compound, it is also not more bioavailable than other Cr compounds.
Institut für Biochemie und Molekulare Zellbiologie, Zentrum für Experimentelle Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Niels
N
Laschinsky
Karin
K
Kottwitz
Barbara
B
Freund
Bernd
B
Dresow
Roland
R
Fischer
Peter
P
Nielsen
D000284:Administration, Oral; D000368:Aged; D000818:Animals; D001682:Biological Availability; D002857:Chromium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002860:Chromium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010649:Phenylalanine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D010848:Picolinic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
D002860:Chromium Radioisotopes; D009539:Nicotinic Acids; D009942:Organometallic Compounds; D010848:Picolinic Acids; C512471:chromium (D-Phenylalanine)3; D002857:Chromium; C079689:chromium tripicolinate; D010649:Phenylalanine; C102874:chromium nicotinic acid complex