Surface-modified protein nanospheres as potential antiviral agents.
A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.
Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel.
Dana
D
Baram-Pinto
Sourabh
S
Shukla
Michal
M
Richman
Aharon
A
Gedanken
Shai
S
Rahimipour
Ronit
R
Sarid
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects; D008623:Mercaptoethanol / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
D000998:Antiviral Agents; D013451:Sulfonic Acids; D012710:Serum Albumin, Bovine; D008623:Mercaptoethanol