Effect of BDNF Val66Met polymorphism on normal variability of executive functions.
Associations of BDNF Val66Met polymorphism with such components of executive functions as verbal fluency, working memory, attention set shifting, and response inhibition were evaluated. A total of 401 healthy volunteers were genotyped. The effect of polymorphism on working memory during the counting test was detected. The test performance in heterozygotic carriers was much worse than in homozygotic ones. Individuals with the MetMet genotype demonstrated the best results, presumably due to molecular mechanisms compensating for the neuropeptide secretion deficiency.
Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia. m.alfimova@gmail.com
M V
MV
Alfimova
G I
GI
Korovaitseva
T V
TV
Lezheiko
V E
VE
Golimbet
D000293:Adolescent; D000328:Adult; D000368:Aged; D001288:Attention / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D057190:Stroop Test; D014633:Valine / Q000235:genetics
D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine