Ultrastructural and stereological study of the liver in chronic mixed HCV+HBV infection.
The stereological values of the structural density of hepatocyte cytoplasmic organelles were similar in chronic mixed HCV+HBV infection irrespective of the form of HBV infection (seropositive or latent). High incidence of HBsAg- and HBeAg-negative forms of HBV infection determines the leading role of PCR diagnosis and studies of liver biopsy specimens with detection of HBcAg structural markers and HBV DNA in native liver tissue in the diagnosis of mixed HCV+HBV infection.
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
O A
OA
Postnikova
S V
SV
Aidagulova
D L
DL
Nepomnyashchikh
Zh V
ZhV
Nokhrina
E V
EV
Vinogradova
Yu Yu
YY
Karavaeva
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D060085:Coinfection; D004279:DNA, Viral / Q000097:blood*; D016174:Hepacivirus / Q000502:physiology; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000097:blood / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D022781:Hepatocytes / Q000648:ultrastructure* / Q000821:virology; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000473:pathology* / Q000821:virology; D008854:Microscopy, Electron; D008875:Middle Aged; D015388:Organelles / Q000648:ultrastructure / Q000821:virology; D016133:Polymerase Chain Reaction
D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens