[Whipple's disease: a case report].
BACKGROUND
Whipple's disease is a chronic, multisystem, infectious disease caused by Tropheryma whipplei. It most commonly affects Caucasian males, middle-aged. Morbus Whipple is primarily gastrointestinal disease, manifested as malabsorption syndrome, and diagnosed by endoscopy and intestinal biopsy. Extraintestinal manifestations are not rare.


METHODS
A 48-year-old male was admitted due to diarrhea, weight loss and weakness in the extremities. Physical examination findings pointed out diffuse hyperpigmentation, pleural effusion and leg edema. Anemia, inflammatory syndrome and malabsorption signs were discovered through laboratory tests. The diagnosis was confirmed by intestinal biopsy. The patient was treated with antibiotic and symptomatic therapy. After 9 months, the patient had no symptoms, and clinical and laboratory findings were regular.


CONCLUSIONS
Whipple's disease is a rare disease. A high degree of clinical suspicion for the disease (malabsorption, arthritis, fever, neurological symptoms) is the most important for diagnosis. Timely diagnosis and appropriate therapy prevent the disease progression and fatal outcome.
Klinika za gastroenterologiju, Klinicki centar Srbije, Beograd, Srbija. dr.popovic@ptt.rs
Dusan Dj
DDj
Popović
Milan
M
Spuran
Ivan
I
Jovanović
Tamara
T
Alempijević
Srdjan
S
Djuranović
Nada
N
Kovacevic
Marjan
M
Micev
Miodrag
M
Krstić
D006801:Humans; D008297:Male; D008875:Middle Aged; D008061:Whipple Disease / Q000175:diagnosis*