Therapeutic targets in cancer cell metabolism and autophagy.
The metabolism of cancer cells is reprogrammed both by oncogene signaling and by dysregulation of metabolic enzymes. The resulting altered metabolism supports cellular proliferation and survival but leaves cancer cells dependent on a continuous supply of nutrients. Thus, many metabolic enzymes have become targets for new cancer therapies. Recently, two processes—expression of specific isoforms of metabolic enzymes and autophagy—have been shown to be crucial for the adaptation of tumor cells to changes in nutrient availability. An increasing number of approved and experimental therapeutics target these two processes. A better understanding of the molecular basis of cancer-associated metabolic changes may lead to improved cancer therapies.
Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Heesun
H
Cheong
Chao
C
Lu
Tullia
T
Lindsten
Craig B
CB
Thompson
D000596:Amino Acids / Q000378:metabolism; D001343:Autophagy; D049109:Cell Proliferation; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology / Q000628:therapy; D009696:Nucleic Acids / Q000378:metabolism
D000596:Amino Acids; D004798:Enzymes; D009696:Nucleic Acids; D005947:Glucose