Meiotic DSBs and the control of mammalian recombination.
The laboratories of Galina Petukhova and R Daniel Camerini-Otero have achieved significant technical advances in determining the genome-wide sites of DNA double-strand breaks (DSBs) where the process of genetic exchange between chromatids during meiosis begins. Applying the new approaches to male meiosis in mice, their experimental results considerably increase our insights into the nature and regulation of these processes.
The Jackson Laboratory, Bar Harbor, ME 04609, USA. ken.paigen@jax.org
Kenneth
K
Paigen
Petko
P
Petkov
D000818:Animals; D002842:Chromatids / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004706:Endodeoxyribonucleases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D011495:Histone-Lysine N-Methyltransferase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D008297:Male; D008540:Meiosis; D051379:Mice; D018345:Mice, Knockout; D011995:Recombination, Genetic; D000099257:Meiotic Recombination Protein SPO11
D004706:Endodeoxyribonucleases; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones; D000099257:Meiotic Recombination Protein SPO11; C534829:prdm9 protein, mouse