Intraperitoneal and intracardiac transfusion of recurrent fetal erythroblastosis due to anti-M alloimmunization with unfavorable outcome.
OBJECTIVE
To present intensive intrauterine treatment of recurrent early onset fetal erythroblastosis due to anti-M alloimmunization.


METHODS
A 33-year-old woman, gravid 3, para 1, had anti-M IgG antibody, which caused alloimmunization of her previous pregnancies. This time she visited our hospital for intensive intervention. No evidence of fetal hydrops was found during ultrasound examination at 12 weeks of gestation. Plasmapheresis was given from 17 weeks of gestation but fetal erythroblastosis still developed 1 week later. Two intraperitoneal transfusions and one intracardiac transfusion were given within three days but fetal erythroblastosis still progressed to fetal bradycardia and occasional asystole. Epinephrine resuscitation could only temporarily improve the fetal heart rate and fetal death was inevitable.


CONCLUSIONS
Serial measurements of fetal middle cerebral artery peak systolic velocities, advanced plasmapheresis, intrauterine blood transfusion, and, if needed, intravenous immunoglobulin supplement, may be the appropriate treatment for early onset fetal erythroblastosis resulting from alloimmunization.
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taiwan.
Tzu-Hung
TH
Lin
Jin-Chung
JC
Shih
Chia-Hui
CH
Lin
Shin-Yu
SY
Lin
Yi-Ning
YN
Su
Chien-Nan
CN
Lee
D000328:Adult; D001805:Blood Transfusion, Intrauterine; D004899:Erythroblastosis, Fetal / Q000209:etiology / Q000628:therapy*; D005260:Female; D005313:Fetal Death; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000276:immunology*; D010529:Peritoneal Cavity; D010956:Plasmapheresis; D011247:Pregnancy; D012008:Recurrence; D016216:Ultrasonography, Prenatal
D007074:Immunoglobulin G; D007075:Immunoglobulin M