[Triterpene compounds from Cirsium setosum].
To investigate chemical constituents contained in cytotoxic petroleum ether extractive fractions from ethanol extracts of Cirsium setosum. The constituents were separated and purified by a combination of various chromatographic methods including silica gel, Sephadex LH-20, and preparative HPLC. Structures of the isolates were elucidated by spectroscopic methods including 1D, 2D NMR and MS methods. The compound structures were also determined by reference to literature. Twelve compounds were separated from the petroleum ether fraction of ethanolic extract and elucidated as lupenyl acetate (1), lupeol (2), lupenone (3), beta-amyrin (4), psi-taraxasterol (5), psi-taraxasteryl acetate (6), taraxasteryl acetate (7), marsformoxide B (8), alpha-amyrenone (9), beta-amyrenone (10), taraxasterone (11) and psi-taraxasterone (12). Of them, compounds 3, 5, 7-12 were separated from this genus for the first time.
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Lingling
L
Li
Zheng
Z
Sun
Xiaoya
X
Shang
Jinjie
J
Li
Rong
R
Wang
Jie
J
Zhu
D002851:Chromatography, High Pressure Liquid; D031180:Cirsium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D053978:Pentacyclic Triterpenes / Q000737:chemistry; D013261:Sterols / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry*; D000094042:Lupanes
D004365:Drugs, Chinese Herbal; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D013261:Sterols; D014315:Triterpenes; C470592:lupenone; D000094042:Lupanes; C073947:alpha-amyrenone; C079988:taraxasterol; C036380:beta-amyrin; C010480:lupeol