[Association analysis between single-nucleotide polymorphisms in the FCER1A gene and serum total IgE level in patients with allergic rhinitis].
OBJECTIVE
To investigate whether the single nucleotide polymorphisms (SNP) in the FCER1A gene are associated with serum total IgE level in Chinese allergic rhinitis (AR) cohort.


METHODS
A total of 378 patients diagnosed as AR was included in this study. Serum total IgE level was detected by UniCAP100 testing system. A total of 8 representativeness marker SNP which were in FCER1A gene region were selected according to the Beijing people database from Hapmap website and the running results of Haploview 4.1 software. The individual genotyping was performed by MassARRAY platform.


RESULTS
Three hundred and seventy-eight individuals (227 males and 151 females) with AR were prospectively recruited. The median of the total serum IgE measurements for the study population were 150 kU/L and ranged from 6.94 kU/L to 5000 kU/L. Levene tests showed the homogeneity of variance of total IgE level among different genotypes regarding each SNP locus. ANOVA tests demonstrated that none of the selected polymorphism loci in FCER1A was associated with total IgE level.


CONCLUSIONS
Present study failed to find an association between SNP in the FCER1A gene region and serum total IgE level in Chinese AR.
Key Laboratory of Otorhinolaryngology, Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing Institute of Otorhinolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Yuan
Y
ZHANG
Yan-ming
YM
ZHAO
Su
S
DUAN
Li-ping
LP
ZHAO
Luo
L
ZHANG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017455:Receptors, IgE / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000235:genetics*; D055815:Young Adult
C475664:FCER1A protein, human; D017455:Receptors, IgE; D007073:Immunoglobulin E