Role of PAPP-A in aging and age-related disease.
As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article.
Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA. Conover.Cheryl@mayo.edu
Cheryl A
CA
Conover
D000367:Age Factors; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*
D011266:Pregnancy-Associated Plasma Protein-A