Laryngeal involvement in pemphigus vulgaris: a proposed classification.
OBJECTIVE
(1) To investigate the incidence of laryngeal involvement in a large series of patients with pemphigus vulgaris, using endoscopic examination, (2) to describe the lesions, and (3) to establish a classification of laryngeal involvement in pemphigus vulgaris based on the location of the lesions.


METHODS
Prospective study.


METHODS
A total of 40 sequentially treated pemphigus vulgaris patients, diagnosed using clinical, histological and immunofluorescence criteria, were evaluated for laryngeal manifestations using endoscopic examination. The results were used to establish a graded classification of laryngeal involvement according to the location of the lesions.


RESULTS
Active laryngeal lesions (ulcers or blisters) were found in 16 patients (40 per cent). Of these, 37.5 per cent were classified as grade I, 20 per cent as grade II, 20 per cent as grade III and 17.5 per cent as grade IV.


CONCLUSIONS
Laryngeal involvement is common in pemphigus vulgaris and must be considered at the point of diagnosis. Grade I lesions are the most frequent.
Department of ENT, São Paulo University School of Medicine, Brazil. alimahmoud79@gmail.com
A
A
Mahmoud
I D
ID
Miziara
K C
KC
Costa
C G
CG
Santi
C W
CW
Maruta
V
V
Aoki
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult