Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity.
Neuroplasticity, the ability of synapses to undergo structural adaptations in response to functional demand or dysfunctions is increasingly impaired in aging and Alzheimer's disease. EGb761® has been shown in several preclinical reports to increase nearly all aspects of impaired neuroplasticity (long-term potentiation, spine density, neuritogenesis, neurogenesis). While all three fractions of constituents (ginkgolides, flavonoids, bilobalide) seem to be active, the flavonoids and specifically the aglycone isorhamnetin seem to be most relevant.
Department of Pharmacology, Biocenter, Goethe-University, Frankfurt, Germany. pharmacolnat@em.uni-frankfurt.de
Walter E
WE
Müller
Jeanine
J
Heiser
Kristina
K
Leuner
D000818:Animals; D020441:Ginkgo biloba; D006801:Humans; D017774:Long-Term Potentiation / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D055495:Neurogenesis / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology; D000096983:Ginkgo Extract
D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract