CD31 and Factor VIII in angiogenesis of normal and pre-eclamptic human placentas.
We aimed to evaluate normal and pre-eclamptic placental vasculature by using CD31 and Factor VIII. We evaluated placentas of 37 pre-eclamptic women by using immunohistochemical staining with CD31 and Factor VIII antibodies. Individual microvessels in the placental tissues were counted at × 100 and × 400 magnification. Microvessel counts were lower in placentas of pre-eclamptic patients compared with healthy controls after staining with CD31 (26.5 ± 5.7 vs 103.9 ± 8.2, p < 0.001) and Factor VIII (24.8 ± 6.7 vs 98.7 ± 10.3, p < 0.001). Balance between proangiogenic and antiangiogenic factors seems to be shifted in favour of anti-angiogenic factors in pre-eclampsia.
Neonatal Intensive Care Unit, Zekai Tahir Burak Maternityand Teaching Hospital, Ankara, Turkey.
N
N
Uras
S S
SS
Oguz
S
S
Zergeroglu
A
A
Akdag
B
B
Polat
E A
EA
Dizdar
U
U
Dilmen
D000328:Adult; D016022:Case-Control Studies; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D018919:Neovascularization, Physiologic; D010920:Placenta / Q000098:blood supply / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000503:physiopathology; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII