The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.
There is significant interest in the development of agents that can ameliorate radiation damage after exposure to radiation has occurred. Here we report that chronic supplementation of the antioxidant Tempol in the diet of mice can reduce body weight without toxicity, decrease cancer, and extend survival when administered after nonlethal total body radiation (TBI). These effects were apparent in two different strains of mice (C3H, CBA) exposed to TBI (3 Gy). Notably, delaying administration of the Tempol diet one month after TBI could also enhance survival. Tempol reduced the incidence of hematopoietic neoplasms (lymphomas) in both strains, whereas both the onset and incidence of nonhematopoietic neoplasms were reduced in CBA mice. These results encourage further study of Tempol as a chemopreventive, to reduce the incidence of radiation-induced second malignancies after a course of definitive radiation therapy. Tempol may also find applications to reduce the risk of cancers in populations exposed to nonlethal radiation due to nuclear accidents or terrorist attacks.
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. jbm@helix.nih.gov
James B
JB
Mitchell
Miriam R
MR
Anver
Anastasia L
AL
Sowers
Philip S
PS
Rosenberg
Maria
M
Figueroa
Angela
A
Thetford
Murali C
MC
Krishna
Paul S
PS
Albert
John A
JA
Cook
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013113:Spin Labels; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D000975:Antioxidants; D003497:Cyclic N-Oxides; D011837:Radiation-Protective Agents; D013113:Spin Labels; C001803:tempol