[Experimental study on in vitro transdermal absorption of Shangshi Zhitong cataplasm].
OBJECTIVE
To conduct an experimental study on in vitro transdermal absorption of prepared Shangshi Zhitong cataplasm.


METHODS
Franz diffusing cells and mice were adopted for the percutaneous penetration study. The accumulative percutaneous permeation of total alkaloids, strychnine and atropine in certain time was determined by acid dye colorimetry and HPLC.


RESULTS
The accumulative permeation of alkaloids (Q) increased with time (t), with a linear relation between them.


CONCLUSIONS
The in vitro percutaneous penetration of Shangshi Zhitong cataplasm complies with the zero-order kinetics.
State Research Center for Research and Development of Traditional Chinese Medicine Multi-ingredient Drugs, Beijing 100075, China.
Xiaoru
X
Wu
Cheng
C
He
Naijie
N
Wang
Yuanyuan
Y
Zhang
Chunxia
C
Xi
Suhua
S
Xie
D000279:Administration, Cutaneous; D000470:Alkaloids / Q000493:pharmacokinetics; D000818:Animals; D001285:Atropine / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D013331:Strychnine / Q000493:pharmacokinetics
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D001285:Atropine; D013331:Strychnine