Occurrence of immunoglobulin M antibodies against several bacterial and viral pathogens in acute hantavirus infection.
Elevated levels of immunoglobulin M antibodies against various pathogens, most frequently Epstein-Barr-virus and Coxiella burnetii, were detected by immunoassay in 15 of 48 patients (31.3%) with acute Puumala virus infections. Although the mechanisms leading to this IgM response are not clear yet, polyspecific immunoglobulin M antibodies have to be taken into account to avoid misinterpretation of serological results in acute hantavirus infection.
Dr. Gaertner and Colleagues Laboratory, Ravensburg, Germany. nele.wellinghausen@labor-gaertner.de
Nele
N
Wellinghausen
Andrea
A
Goetz
Ursula
U
Weber
D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D016997:Coxiella burnetii / Q000276:immunology; D018778:Hantavirus Infections / Q000276:immunology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D029262:Puumala virus / Q000302:isolation & purification
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007075:Immunoglobulin M