Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells.
We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein β-casein in the presence of prolactin and hydrocortisone. It was found that β-casein expression is accompanied by cyclin D1 coexpression.
Institute of Carcinogenesis, N. N. Blokhin Rassian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. sainhershy@yandex.ru
S S
SS
Shushanov
D000818:Animals; D015153:Blotting, Western; D002364:Caseins / Q000378:metabolism*; D002460:Cell Line; D019938:Cyclin D1 / Q000378:metabolism; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008321:Mammary Glands, Animal; D051379:Mice; D011388:Prolactin / Q000494:pharmacology
D002364:Caseins; D019938:Cyclin D1; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D011388:Prolactin; D006854:Hydrocortisone