[Epidemiological analysis of Streptococcus pneumoniae in Gifu prefecture and the northern district of Aichi prefecture--2009].
High pathogenicity and drug resistance of Streptococcus pneumoniae are serious problem in clinical practice. Since 1999, we have conducted epidemiologic analyses of S. pneumoniae in Chubu district. We report the results of the analysis conducted in 2009. Three hundred and eight (308) S. pneumoniae isolates with a gene coding for autolysin lyt-A, which had been isolated from patients at 21 medical institutions in Gifu prefecture and the northern part of Aichi prefecture in 2009, were enrolled in this study. The strains were classified according to their drug resistance based on the presence of the pbp mutation, and examined for the presence of the two macrolide-resistance genes, ermB and mefA. Moreover, they were serotyped using type-specific antisera. The mean age of the patients from whom these S. pneumoniae strains were isolated, was 23.4 +/- 30.1 years old, and children aged 15 years old or less accounted for 66% of all the patients. Genotype penicillin-susceptible S. pneumoniae (gPSSP), genotype penicillin-intermediate S. pneumoniae (gPISP) and genotype penicillin-resistant S. pneumoniae (gPRSP) were 22 (7.1%), 131 (42.5%) and 155 (50.3%), respectively. The strains with mefA positive and ermB negative, mefA negative and ermB positive, and mefA positive and ermB positive were 80 (26.0%), 153 (49.7%), and 47 (15.3%), respectively. The MIC90 values of tebipenem (TBPM) and faropenem were 0.06 microg/mL and 0.5 microg/mL, respectively. TBPM showed the high bactericidal activity against gPRSP. In carbapenems, panipenem and biapenem exhibited higher bactericidal activities. Quinolone-resistant S. pneumoniae (QRSP) were isolated from 10 (3.2%). QRSP dominated 5 (7.9%) and 3 (1.5%) among the elderly (over 65 years old) and children, respectively. (As for the serotype, serotypes 6, 19 and 23 were 60 (19.5%), 62 (20.1%), and 44 (14.3%), respectively. Further epidemiologic studies on S. pneumoniae might be required also in the future, including the relationship between the serotype and drug resistance.
Department of Infection Control and Prevention, Aichi Medical University Hospital.
Yuka
Y
Yamagishi
Hiroshige
H
Mikamo
Haruki
H
Sawamura
Hiroyuki
H
Suematsu
Yuko
Y
Asano
Shiomi
S
Ishigo
Masakazu
M
Hatano
Shigenori
S
Matsubara
Hirotoshi
H
Ohta
Yoko
Y
Matsukawa
Hiroikazu
H
Saeki
Toshihiro
T
Mutou
Mayumi
M
Teraji
Tetsuo
T
Mouri
Yuki
Y
Kawahara
Shigeki
S
Akita
Takanori
T
Miyabe
Masako
M
Okada
Hiroshi
H
Terada
Takashi
T
Sakuma
Eri
E
Morita
Naoya
N
Miyamoto
Yoko
Y
Tuchiya
Yukiji
Y
Yamada
Kazukiyo
K
Yamaoka
Yuki
Y
Miyaki
Kaori
K
Tanaka
Kunitomo
K
Watanabe
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D007564:Japan; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*