Autoimmune pancreatitis accompanied with recurrence of bladder cancer: difficulty in diagnosis and management of systemic lesions in a case with autoimmune pancreatitis.
BACKGROUND
A case of autoimmune pancreatitis develops a hepatic metastasis of bladder cancer resected over 5 years before, mimicking a pseudotumor of the liver.


METHODS
A 71-year-old man with a surgical history of bladder cancer (pT4, G2&gt;3, N (+)) later developed autoimmune pancreatitis. Diagnosis of autoimmune pancreatitis was not problematic; however, a variety of systemic disorders appeared after the onset of autoimmune pancreatitis, possibly associated with autoimmune disorder or steroid therapy. These included pancreatic stone attack, septic shock due to ureteral stenosis, and bloody phlegm due to a lung aspergilloma. These events were not easily controlled but were managed with clinical efforts. In the following course, pelvic lymph nodes gradually enlarged and a hepatic mass occurred at 5 years and 6 months after total cystectomy. Several candidates were considered for the hepatic lesion including inflammatory pseudotumor, cholangiocellular carcinoma, and hepatic adenoma. However, percutaneous biopsy confirmed metastasis of the bladder cancer. In general, recurrence after 5 years following cystectomy is extremely rare in cases of pT4 bladder cancer with lymph node metastasis.


CONCLUSIONS
Patients of autoimmune pancreatitis display various problematic scenarios in diagnosis and long-term management, not only for their pancreatic lesions but also for systemic lesions.
Division of Endoscopy, Shizuoka Cancer Center, Nagaizumi, Suntogun, Shizuoka, Japan. h.matsubayashi@scchr.jp
Hiroyuki
H
Matsubayashi
Hirokazu
H
Kimura
Kenichi
K
Tobisu
Yoshifumi
Y
Onishi
Michihisa
M
Moriguchi
Keiko
K
Sasaki
Hiroyuki
H
Ono
D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local; D010195:Pancreatitis / Q000175:diagnosis* / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*