d(TG(n)T) DNA sequences do not necessarily form tetramolecular G-quadruplexes.
Contrasting with the common belief that d(TG(n)T) DNA sequences would form tetramolecular G-quadruplex assemblies, mass spectrometry reveals that these sequences tend to fold into G-quadruplex trimers, dimers, and eventually monomers as the G-tract length increases. The final structure also depends on the ionic strength.
Physical Chemistry and Mass Spectrometry Laboratory, Department of Chemistry, University of Liège, B-4000 Liège, Belgium.
Laure
L
Joly
Frédéric
F
Rosu
Valérie
V
Gabelica
D001483:Base Sequence; D002942:Circular Dichroism; D054856:G-Quadruplexes; D013058:Mass Spectrometry; D017510:Protein Folding