Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity.
Synthesis of carbazole substituted chalcone urea derivatives and their polyphenol oxidase enzyme activity effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The results showed that most of the compounds (3,4,5a,5d-h) inhibited and some of them (5c,5i-l) activated the tyrosinase enzyme activity. The molecular calculations were performed using Gaussian software for the synthesized compounds to explain the experimental results.
Chemistry Department, Faculty of Mathematical & Natural Sciences, University of Prishtina, Prishtina, Republic of Kosova.
Arleta Rifati
AR
Nixha
Mustafa
M
Arslan
Yusuf
Y
Atalay
Nahit
N
Gençer
Adem
A
Ergün
Oktay
O
Arslan
D002227:Carbazoles / Q000737:chemistry*; D004156:Catechol Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002599:Chalcone / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D015394:Molecular Structure; D012984:Software; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D002227:Carbazoles; C041514:carbazole; D002599:Chalcone; D014508:Urea; D004156:Catechol Oxidase