Effects of analogues of hydra peptide morphogen on DNA synthesis in the myocardium of newborn albino rats.
DNA-synthetic activity of myocardial cells was studied by (3)H-thymidine autoradiography in newborn albino rats after intraperitoneal injection of hydra peptide morphogen and its analogues. Administration of hydra peptide morphogen stimulated proliferative activity in the myocardium. Short analogues of hydra peptide morphogen, 6C and 3C peptides, produced a similar effect. Administration of arginine-containing analogue of hydra peptide morphogen significantly reduced the number of DNA-synthesizing nuclei in the ventricular myocardium of newborn albino rats. The role of the structure of the peptide molecule in the realization of the morphogenetic effects of hydra peptide morphogen is discussed.
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk, Russia. sazen@mail.ru
E N
EN
Sazonova
I G
IG
Yakovenko
S Yu
SY
Kryzhanovskaya
A A
AA
Budylev
S S
SS
Timoshin
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001120:Arginine / Q000032:analysis; D001345:Autoradiography; D049109:Cell Proliferation / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007274:Injections, Intraperitoneal; D008817:Mice, Mutant Strains; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D009479:Neuropeptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D009479:Neuropeptides; D010455:Peptides; C032522:head activator peptide; D001120:Arginine; D011761:Pyrrolidonecarboxylic Acid