[Extramedullary relapse of acute lymphoblastic leukemia in the breast after unrelated allogeneic bone marrow transplantation].
A 28-year-old female presented with an isolated extramedullary relapse in the breast following an unrelated allogeneic bone marrow transplantation(UBMT)for acute lymphoblastic leukemia. She complained of a tumor in her right breast with hematological complete remission 23 months after her first UBMT. The extramedullary lesion resolved with chemotherapy, and she then received a second UBMT. Although there had been no relapse of leukemia in the bone marrow and extramedullary sites, she died from a herpes simplex virus infection in the central nervous system. Extramedullary relapses in the so-called 'sanctuary'sites after hematopoietic stem cell transplantation are unusual, and breast recurrences are even more rare. A treatment strategy for unusual sites of relapse after BMT should be established.
Dept. of Hematology, Kanagawa Cancer Center, Japan.
Ayumi
A
Numata
Masatsugu
M
Tanaka
Takayoshi
T
Tachibana
Atsuo
A
Maruta
Heiwa
H
Kanamori
Yoshiaki
Y
Ishigatsubo
Hiroshi
H
Harada
Hiraku
H
Mori
D016026:Bone Marrow Transplantation; D001940:Breast / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous; D061349:Unrelated Donors