Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model.
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E(2) (PGE(2)). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE(2). The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE(2) pathways.
College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Dajeong
D
Kim
Dongsun
D
Park
Jangbeen
J
Kyung
Yun-Hui
YH
Yang
Ehn-Kyoung
EK
Choi
Yoon-Bok
YB
Lee
Hyun-Kyu
HK
Kim
Bang Yeon
BY
Hwang
Yun-Bae
YB
Kim