IgG autoantibody response against keratinocyte cadherins in endemic pemphigus foliaceus (fogo selvagem).
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gustavo
G
Flores
Donna A
DA
Culton
Phillip
P
Prisayanh
Bahjat F
BF
Qaqish
Kirk
K
James
Mike
M
Maldonado
Valeria
V
Aoki
Gunter
G
Hans-Filho
Evandro A
EA
Rivitti
Luis A
LA
Diaz
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001938:Brazil; D015820:Cadherins / Q000235:genetics / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D051183:Desmoglein 1 / Q000235:genetics / Q000276:immunology; D051301:Desmoglein 2 / Q000235:genetics / Q000276:immunology; D051184:Desmoglein 3 / Q000235:genetics / Q000276:immunology; D051182:Desmogleins / Q000235:genetics / Q000276:immunology; D051181:Desmosomal Cadherins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology*; D012372:ROC Curve; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D014481:United States
D001323:Autoantibodies; D015820:Cadherins; C495297:DSG1 protein, human; C495314:DSG2 protein, human; C071894:DSG3 protein, human; C473409:DSG4 protein, human; D051183:Desmoglein 1; D051301:Desmoglein 2; D051184:Desmoglein 3; D051182:Desmogleins; D051181:Desmosomal Cadherins; D007074:Immunoglobulin G; D011994:Recombinant Proteins