Role of various subtypes of muscarinic cholinergic receptors in the development of posthemorrhagic abnormalities in systemic and portal circulation in rats.
The experiments employing high-frequency ultrasonic technique and selective blockers of M1, M3, and M4 muscarinic cholinergic receptors pirenzepine, 4-DAMP, and tropicamide, respectively, revealed individual roles of these receptors in the development of severe posthemorrhagic hypotension in rats with low or high individual resistance to circulatory hypoxia. The study showed that M1 and M4 muscarinic receptors are involved in shock-limiting and shock-activating processes, respectively, while M3 receptors exert no effect on the course of posthemorrhagic abnormalities in systemic and hepatic portal circulation and on the posthemorrhagic lifespan. Poor resistance of the cardiovascular system to circulatory hypoxia during shock development is considered to be dysregulatory pathology.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
N Ya
NY
Kovalenko
D D
DD
Matsievskii
V K
VK
Reshetnyak
D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D006470:Hemorrhage / Q000150:complications*; D007022:Hypotension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010880:Piperidines; D010890:Pirenzepine; D051381:Rats; D017208:Rats, Wistar; D043643:Receptor, Muscarinic M1 / Q000037:antagonists & inhibitors / Q000502:physiology*; D043587:Receptor, Muscarinic M3 / Q000037:antagonists & inhibitors / Q000502:physiology*; D043588:Receptor, Muscarinic M4 / Q000037:antagonists & inhibitors / Q000502:physiology*; D014331:Tropicamide
D018727:Muscarinic Antagonists; D010880:Piperidines; D043643:Receptor, Muscarinic M1; D043587:Receptor, Muscarinic M3; D043588:Receptor, Muscarinic M4; D010890:Pirenzepine; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; D014331:Tropicamide