Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA.
The Myomatrix 2012 conference held April 22-24th, 2012 at the University of Nevada, Reno convened 73 international participants to discuss the dynamic relationship between muscle and its matrix in muscular dystrophy with a specific focus on congenital muscular dystrophy. Seven sessions over 2½ days defined three central themes: (1) the role of extracellular matrix proteins and compartments in development and specifically in congenital muscular dystrophy (CMD) (2) the role of extracellular matrix signaling and adhesion to membrane receptors and (3) the balance and interplay between inflammation and fibrosis as drivers of altered matrix stiffness, impaired regeneration and progressive dystrophy. This report highlights major conference findings and the translational roadmap as defined by conference attendees.
Kaiser SCPMG, Cure CMD, P.O. Box 701, Olathe, KS 66051, USA.
Anne
A
Rutkowski
Carsten
C
Bönnemann
Susan
S
Brown
Sólveig
S
Thorsteinsdóttir
Janice
J
Dominov
Markus A
MA
Ruegg
Michelle L
ML
Matter
Denis
D
Guttridge
Rachelle H
RH
Crosbie-Watson
Gabrielle
G
Kardon
Kanneboyina
K
Nagaraju
Mahasweta
M
Girgenrath
Dean J
DJ
Burkin
D005109:Extracellular Matrix / Q000502:physiology*; D005355:Fibrosis; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000503:physiopathology*; D012508:Sarcolemma / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology