Effects of heparin on synaptic activity in the hemorrhagic stroke model in vitro.
We studied the ability of heparin to modify synaptic activity on the original stroke model in vitro. Cultured slices of the brain slices from hypertensive rats were treated with the autoblood clot. Administration of heparin (2 mg/ml) before autoblood treatment had a protective effect on ionotropic glutamatergic and GABAergic receptors, whose activity was inhibited by the blood.
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
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Mokrushin
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Pavlinova
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001777:Blood Coagulation; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D020299:Intracranial Hemorrhage, Hypertensive / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D018079:Receptors, GABA / Q000378:metabolism; D058468:Receptors, Ionotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D020521:Stroke / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D055366:Synaptic Potentials / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D046509:Tissue Culture Techniques
D005343:Fibrinolytic Agents; D018079:Receptors, GABA; D058468:Receptors, Ionotropic Glutamate; D006493:Heparin; D001241:Aspirin