Myasthenia gravis: sleep quality, quality of life, and disease severity.
BACKGROUND
There is much research on quality of life in myasthenia gravis (MG), and its relationship to disease severity is well-established. However, evidence regarding sleep disturbance in MG is inconclusive.


METHODS
To evaluate sleep and quality of life among clinically stable MG patients, 54 subjects were investigated by means of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and 15-Item-Quality-Of-Life Instrument for MG (MG-QOL15).


RESULTS
A pathological PSQI score, which was observed in 59% of patients, was increased in subjects with active disease compared with patients in clinical remission [odds ratio = 4.3; confidence interval 95% (1.0-17.6); P = 0.04]. We found a relationship between PSQI and MG-QOL15 scores in patients with clinically active disease (r = 0.62; P < 0.001).


CONCLUSIONS
Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG-specific risk factor for patient-reported sleep disturbance. The MG-QOL15 and PSQI should be used to estimate the impact of the disease on sleep and quality of life.
Department of Neurology, Complejo Hospitalario de Navarra, Irunlarrea Street, 3, 31008 Pamplona, Spain. elenahmlapiscina@gmail.com
Elena Hernández
EH
Martínez-Lapiscina
Elena Hernández
EH
Martínez De Lapiscina
María Elena
ME
Erro
María Elena
ME
Erro Aguirre
Teresa
T
Ayuso
Teresa
T
Ayuso Blanco
Ivonne
I
Jericó
Ivonne
I
Jericó Pascual
D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications / Q000175:diagnosis*; D011795:Surveys and Questionnaires