The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis.
OBJECTIVE
To evaluate of metformin effectiveness of ovulation induction treatment in polycystic ovary syndrome (PCOS) women.


METHODS
Eight databases and nine related journals were searched for randomized controlled trails (RCTs) on the comparison between metformin and clomiphene citrate used for PCOS women. Meta analysis was performed after quality assessment.


RESULTS
Ovulation rate in metformin group compared with clomiphene citrate group was lower with a significant difference [OR = 0.48 (0.26-0.87), p = 0.01]; no significant difference was found for pregnancy rate [OR = 0.94 (0.26-3.43)], miscarriage rate [OR = 0.63 (0.06-6.47)] between two groups. Compared with the combination of metformin and clomiphene citrate group, pregnancy rate in metformin group was significantly lower [Peto OR = 1.56 (1.16-2.08), p = 0.003], but there was no significant difference in the two groups about ovulation rate [OR = 1.52 (0.95-2.45)], miscarriage rate [Peto OR = 1.40 (0.79-2.48)].


CONCLUSIONS
Compared with clomiphene citrate, metformin used for ovulation induction treatment in PCOS women, can promote ovulation induction and pregnancy rate, the effect of the combination treatment is better than that of a single drug use.
Unit for Human Reproduction, Taihe Hospital of Hubei University of Medicine, Shiyan, Hubei, China. xjs660310@163.com
Jinsong
J
Xiao
Shuangyun
S
Chen
Chunlian
C
Zhang
Shang
S
Chang
D000022:Abortion, Spontaneous / Q000453:epidemiology; D002996:Clomiphene / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004965:Estrogen Antagonists / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control; D008687:Metformin / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D016032:Randomized Controlled Trials as Topic
D004965:Estrogen Antagonists; D005300:Fertility Agents, Female; D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin