A model of hyperhomocysteine-induced endothelial dysfunction in rats.
Intragastric methionine (3 g/kg daily for 7 days) elevates homocysteine concentration and increases the endothelial dysfunction coefficient. This protocol of methionine treatment is an adequate model of hyperhomocysteine-induced endothelial dysfunction and can be used for studies of the endothelio- and cardioprotective effects of drugs.
Kursk State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Russia. mkorokin@mail.ru
M V
MV
Korokin
M V
MV
Pokrovskiy
O O
OO
Novikov
O S
OS
Gudyrev
V V
VV
Gureev
T A
TA
Denisyuk
L V
LV
Korokina
L M
LM
Danilenko
V A
VA
Ragulina
E A
EA
Konovalova
A S
AS
Belous
D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology*; D020138:Hyperhomocysteinemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008715:Methionine / Q000627:therapeutic use; D051381:Rats; D014652:Vascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*
D008715:Methionine