[Brucine chitosan thermosensitive hydrogel for intra-articular injection].
The aim of this study was to develop a sustained release converse thermosensitive hydrogel for intra-articular injection using chitosan-glycerol-borax as matrix, its physical properties and biocompatibility were investigated. Taking gelation time and gelation condition as index, the influence of concentration of chitosan, ratio of chitosan to glycerol, pH on physical properties of hydrogel were investigated. And then the in vitro drug release, rheological properties and biocompatibility were studied. The thermosensitive hydrogel flows easily at room temperature and turns to gelation at body temperature, which can certainly prolong the release of drug and has good biocompatibility.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China. czpcpu2000@hotmail.com
Zhi-Peng
ZP
Chen
Wen
W
Liu
Hong-Xuan
HX
Chen
Bao-Chang
BC
Cai
D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D000818:Animals; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000139:chemically induced; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects; D008297:Male; D008422:Materials Testing; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology; D012639:Seeds / Q000737:chemistry; D013331:Strychnine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D031461:Strychnos nux-vomica / Q000737:chemistry; D013499:Surface Properties; D013570:Synaptic Membranes / Q000187:drug effects; D013696:Temperature
D000700:Analgesics; D003692:Delayed-Action Preparations; D020100:Hydrogels; C083806:brucine; D048271:Chitosan; D013331:Strychnine