Long-term prognosis of adult patients with isolated congenital left ventricular aneurysm or diverticulum and abnormal electrocardiogram patterns.
BACKGROUND
Congenital left ventricular aneurysm (LVA) and diverticulum (LVD) are rare cardiac anomalies frequently associated with electrocardiogram (ECG) abnormalities. The aim of this study was to evaluate the long-term prognosis in such patients.


RESULTS
A total of 108 patients with LVA or LVD having ECG-abnormalities were assessed. The patients were classified into 2 groups according to ECG abnormalities: a distinct ECG group (8 ECG patterns known to be frequently associated with LVA/LVD); and a control group (all other ECG abnormalities). The primary endpoint was a composite of cardiac death, rhythm disturbances, syncope, embolic events, and hospitalization for cardiovascular events. Mean patient age was 64±10 years; 45 (42%) were male; median follow-up (FU) was 50 months. The primary endpoint occurred in 12/27 patients from the distinct ECG group and in 15/81 patients in the control group (44% vs. 19%; P=0.01). Cardiac event rate per year (CER) was 1.8% vs. 0.8%, respectively. There were no cardiac deaths during FU. Symptoms (arrhythmia-related symptoms, syncope, and embolic events) at time of diagnosis increased the incidence of adverse events during FU (70% vs. 28%; P=0.05; CER 2.9% vs. 1.1%). Age ≥64 years, presence of LVD, gender, and location of the anomaly did not affect the incidence of adverse events.


CONCLUSIONS
The incidence of adverse events in symptomatic patients with isolated LVA or LVD and distinct abnormal ECG patterns is increased during long-term FU. None of the present patients, however, experienced cardiac death.
Department of Cardiology, Zentralklinik Bad Berka, Robert-Koch-Allee 9, 99437 Bad Berka, Germany. m.ohlow.kar@zentralklinik-bad-berka.de
Marc-Alexander
MA
Ohlow
Bernward
B
Lauer
Ulrich
U
Lotze
Michele
M
Brunelli
J Christoph
JC
Geller
D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D004240:Diverticulum / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006322:Heart Aneurysm / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015996:Survival Rate; D013997:Time Factors