[Study of novel artificial lung surfactants incorporating partially fluorinated amphiphiles].
Lung surfactants (LS), a complex of ∼90 wt% lipids (mainly dipalmitoylphosphatidylcholine or DPPC) and ∼10 wt% surfactant proteins (SP-A, -B, -C, and -D), adsorb to an air-alveolar fluid interface and then lower its surface tension down to near zero during expiration. Intratracheal instillation of exogenous LS preparations can effectively compensate for surfactant deficiency in premature infants with respiratory distress syndrome (RDS). Surfacten® (Mitsubishi Tanabe Pharma Corporation, Osaka, Japan), a modified bovine lung extract and an effective surfactant replacement in treatment for RDS patients, is supplemented with DPPC, palmitic acid, and tripalmitin. For the premature infants suffering from RDS, instillation of Surfacten® leads to a dramatic improvement in lung function and compliance. Herein, the author reviews potential use of newly designed preparations containing a mimicking peptide of SP-B and also introduces the current research on the preparations incorporated with partially fluorinated amphiphiles to improve their efficacy.
Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, Japan. nakahara@niu.ac.jp
Hiromichi
H
Nakahara
D015060:1,2-Dipalmitoylphosphatidylcholine; D015195:Drug Design; D045853:Exhalation / Q000502:physiology; D005459:Fluorides; D054879:Halogenation; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance / Q000502:physiology; D019308:Palmitic Acid; D011650:Pulmonary Alveoli / Q000378:metabolism; D037701:Pulmonary Surfactant-Associated Protein B; D011663:Pulmonary Surfactants / Q000378:metabolism / Q000627:therapeutic use; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000209:etiology; D013501:Surface-Active Agents; D014280:Triglycerides
D037701:Pulmonary Surfactant-Associated Protein B; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents; D014280:Triglycerides; D015060:1,2-Dipalmitoylphosphatidylcholine; D019308:Palmitic Acid; C005859:tripalmitin; D005459:Fluorides