[The influence of T lymphocyte activation on HIV-1 susceptibility of Han Chinese].
OBJECTIVE
To explore the influence of T lymphocyte activation on HIV-1 susceptibility of Han Chinese.


METHODS
In 2008, 37 HIV-1 highly exposed persistently seronegative individuals (ESNs) and 101 healthy controls were screened from Shenzhen. Flow cytometer was used to assay the expression difference of HIV-1 infection related co-receptor, the difference between the two groups were analyzed by Mann-Whitney U statistics methods.


RESULTS
T cell HLA-DR(+) CD4 T cells and HLA-DR(+) expression of ESNs (12.64 (5.94 - 21.90), 21.12 (10.74 - 30.21)) were all significantly lower than that of healthy controls (22.52 (7.91 - 58.60), 32.28 (14.72 - 67.82)) (P values all < 0.05). T cell CD45RA-RO(+), CCR5(+)CD4 expression of ESNs (58.68 (49.06 - 72.44), 21.93 (15.84 - 25.89)) were all significantly higher than that of healthy controls (53.17 (42.63 - 63.21), 16.14 (11.94 - 21.98)) (P values all < 0.05). T cell CXCR4(+)CD4 T cells expression of ESNs (93.67 (92.17 - 94.96)) was significantly lower than that of healthy controls (95.16 (92.99 - 96.77)) (P values all < 0.05). Healthy controls and ESNs could be divided into low expression group and high expression group according to HLA-DR(+)CD8 T cells bimodal distribution. A total of 89.2% (33/37) ESNs fell into HLA-DR + CD8 low expression group, and 58.4% (59/101) of the healthy controls located in low expression group (P < 0.05).


CONCLUSIONS
To Han Chinese, the low activation status of T lymphocyte has significant correlation with HIV-1 low susceptibility.
Department of AIDS Control and Prevention, Shenzhen Center for Disease Control and Prevention, China.
Xiao-hui
XH
Wang
Yi-hua
YH
Xu
Lin
L
Chen
Sheng
S
Wei
Zheng-rong
ZR
Yang
Xiang-dong
XD
Shi
Yan
Y
Zhang
Yong-xia
YX
Gan
Shao-fa
SF
Nie
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology*; D000328:Adult; D044466:Asian People; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005260:Female; D015497:HIV-1; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D055815:Young Adult