Sulfated cellulose derivatives inhibit activities of thrombin and activated factor X.
Sulfated derivatives based on powdered cellulose were obtained, including those containing additional (carboxymethyl, ethyl amide or phosphate) groups, and their activity against blood clotting factors (thrombin and Xa) was studied. Maximum antithrombin activity of the test compounds, measured using a coagulation test, was 144±11 U/mg.
Laboratory of Pathology and Pharmacology of Hemostasis, Hematological Research Center, Russian Academy of Medical Sciences, Moscow, Russia. nndrozd@mail.ru
N N
NN
Drozd
M A
MA
Torlopov
A I
AI
Davydova
V A
VA
Makarov
D000991:Antithrombins / Q000737:chemistry / Q000494:pharmacology*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D015951:Factor Xa; D006801:Humans; D008970:Molecular Weight; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013431:Sulfates / Q000737:chemistry / Q000494:pharmacology*; D013917:Thrombin; D013918:Thrombin Time
D000991:Antithrombins; D013431:Sulfates; D002482:Cellulose; D013917:Thrombin; D015951:Factor Xa