Effect of chronic periodontitis on oxidative status in patients with rheumatoid arthritis.
BACKGROUND
Rheumatoid arthritis (RA) and chronic periodontitis (CP) are the most common chronic inflammatory diseases and have remarkable similar pathologies. The aim of this study is to investigate the impact of periodontal status on oxidative stress in patients with RA by evaluating serum oxidative parameters and prolidase levels.


METHODS
For this cross-sectional comparative study, the following four groups were composed of 20 individuals each (80 individuals total): 1) RA with CP (RA-CP group); 2) RA but periodontally healthy (RA-C group); 3) systemically healthy with CP (CP group); and 4) systemically and periodontally healthy (C group). Demographic, periodontal, rheumatological, and serum oxidative parameters as determined by serum total antioxidant status, total oxidant status, oxidative stress index (OSI), lipid hydroperoxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, prolidase level, and total sulfhydryl groups were evaluated.


RESULTS
The OSI values of the RA-CP group were statistically significantly higher than those of the C group (P <0.05). The prolidase levels of the RA-C, RA-CP groups and the CP group were statistically higher than those of the C group (P = 0.001, P = 0.007, and P = 0.001, respectively).


CONCLUSIONS
Although CP and RA each increase oxidative stress, in a small sample size these effects are only significant when both CP and RA are combined relative to neither exposure. In addition, increased prolidase levels in patients with RA and CP may be related to increased oxidative tissue damage.
Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. ufuxezer@yahoo.com
Ufuk
U
Sezer
Kamile
K
Erciyas
Kemal
K
Ustün
Yavuz
Y
Pehlivan
Süleyman Ziya
SZ
Şenyurt
Nurten
N
Aksoy
Mehmet
M
Tarakçıoğlu
Seyithan
S
Taysı
Ahmet Mesut
AM
Onat
D000328:Adult; D000975:Antioxidants / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis; D055113:Chronic Periodontitis / Q000097:blood / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004150:Dipeptidases / Q000097:blood; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000097:blood
D000975:Antioxidants; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D016877:Oxidants; D013438:Sulfhydryl Compounds; D002570:Ceruloplasmin; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D004150:Dipeptidases; C022449:proline dipeptidase