The asymmetric synthesis of CF3- or -CF2-substituted tetrahydroquinolines by employing a chiral phosphoric acid as catalyst.
CF(3)- or -CF(2)-containing tetrahydroquinolines have been asymmetrically synthesized from the reaction of fluorinated N-arylimines with benzyl N-vinylcarbamate in the presence of a chiral phosphoric acid.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, P. R. China.
Jin-Hong
JH
Lin
Guoqiang
G
Zong
Ruo-Bing
RB
Du
Ji-Chang
JC
Xiao
Shubin
S
Liu
D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism; D014520:Urethane / Q000031:analogs & derivatives* / Q000737:chemistry
D006845:Hydrocarbons, Fluorinated; D010756:Phosphoric Acids; D011804:Quinolines; D014520:Urethane; C017963:vinyl carbamate; C542964:1,2,3,4-tetrahydroquinoline