[The assessment of the state of the immune system in the patients presenting with bronchial asthma and concomitant diseases of the nasal cavity and paranasal sinuses].
The objective of the present investigation was to study the influence of diseases of the nasal cavity (NC) and paranasal sinuses (PNS) concomitant with bronchial asthma (BA) on the development of peculiar features of the patients' immune status. Phenotypic characteristics of the main lymphocyte subpopulations from peripheral blood of 101 patients were obtained by means of flow cytometry with the use of fluorescein isocyanate- or phycoerythrin-labeled monoclonal antibodies. Special emphasis was laid on the elucidation of characteristics of humoral and cell-mediated immunity in the patients presenting with BA and concomitant NC and PNS diseases and their comparison with the respective parameters in the patients with isolated lesions in the upper respiratory tract (allergic rhinitis and polypous rhinosinusitis) and lower respiratory tract (bronchial asthma). It was shown that the patients with concurrent lesions of the upper and lower respiratory tracts experience marked intensification of the immune reactions in the form of the elevated number of activated B-lymphocytes (CD23+), serum IgE level, and peripheral eosinophil count.
N V
NV
Chichkova
A S
AS
Lopatin
E P
EP
Gitel'
N S
NS
Suleĭmanova
D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000276:immunology; D010254:Paranasal Sinus Diseases / Q000453:epidemiology* / Q000276:immunology*; D010256:Paranasal Sinuses / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D055815:Young Adult