Long-term recordings of local field potentials from implanted deep brain stimulation electrodes.
BACKGROUND
Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS is not responsive to an individual's disease state, and programming parameters, once established, do not change to reflect disease state. Local field potentials (LFPs) recorded from DBS electrodes are being investigated as potential biomarkers for the Parkinson disease state. However, no patient data exist about what happens to LFPs over the lifetime of the implant.


OBJECTIVE
We investigated whether LFP amplitude and response to limb movement differed between patients implanted acutely with subthalamic nucleus DBS electrodes and patients implanted 2 to 7 years previously.


METHODS
We recorded LFPs at DBS surgery time (9 subjects), 3 weeks after initial placement (9 subjects), and 2 to 7 years (median: 3.5) later during implanted programmable generator replacement (11 sides). LFP power-frequency spectra for each of 3 bipolar electrode derivations of adjacent contacts were calculated over 5-minute resting and 30-second movement epochs. Monopolar impedance data were used to evaluate trends over time.


RESULTS
There was no significant difference in β-band LFP amplitude between initial electrode implantation (OR) and 3-week post-OR times (P=.94). However, β-band amplitude was lower at implanted programmable generator replacement times than in OR (P=.008) and post-OR recordings (P=.039). Impedance measurements declined over time (P<.001).


CONCLUSIONS
Postoperative LFP activity can be recorded years after DBS implantation and demonstrates a similar profile in response to movement as during acute recordings, although amplitude may decrease. These results support the feasibility of constructing a closed-loop, patient-responsive DBS device based on LFP activity.
Department of Neurosurgery, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55414, USA. aabosch@umn.edu
Aviva
A
Abosch
David
D
Lanctin
Ibrahim
I
Onaran
Lynn
L
Eberly
Maggie
M
Spaniol
Nuri Firat
NF
Ince
D000328:Adult; D000368:Aged; D001611:Beta Rhythm / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D006225:Hand / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D013057:Spectrum Analysis; D020531:Subthalamic Nucleus / Q000502:physiology; D013997:Time Factors