Investigating the acoustic release of doxorubicin from targeted micelles.
The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side effects of chemotherapy by preferentially targeting tumor cells both actively (e.g. a folate receptor) and using external stimulus (e.g. ultrasound). In this paper, we report the synthesis of Pluronic P105 micelles with a folate targeting moiety (with a yield of 48%) containing doxorubicin (Dox). We applied low frequency ultrasound as an external stimulus and measured the amount of release of Dox from these folated micelles. The results showed that the percent drug release increases as the power intensity of ultrasound increases. The maximum amount of release (14%) was measured at 5.4 W/cm(2). A power density threshold at approximately 0.55 W/cm(2) exists below which no statistically significant release was observed. This lower threshold suggests that cavitation plays an important role in triggering drug release from targeted micelles.
Chemical Engineering Department, American University of Sharjah, United Arab Emirates. ghusseini@aus.edu
Ghaleb A
GA
Husseini
Diana
D
Velluto
Laura
L
Kherbeck
William G
WG
Pitt
Jeffrey A
JA
Hubbell
Douglas A
DA
Christensen
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D005079:Excipients; D005453:Fluorescence; D005492:Folic Acid / Q000737:chemistry; D007202:Indicators and Reagents; D008823:Micelles; D010316:Particle Size; D020442:Poloxamer; D014465:Ultrasonics
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D007202:Indicators and Reagents; D008823:Micelles; D020442:Poloxamer; D004317:Doxorubicin; D005492:Folic Acid; C519610:pluronic P105