Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan. yokada@src.riken.jp
Yukinori
Y
Okada
Xueling
X
Sim
Min Jin
MJ
Go
Jer-Yuarn
JY
Wu
Dongfeng
D
Gu
Fumihiko
F
Takeuchi
Atsushi
A
Takahashi
Shiro
S
Maeda
Tatsuhiko
T
Tsunoda
Peng
P
Chen
Su-Chi
SC
Lim
Tien-Yin
TY
Wong
Jianjun
J
Liu
Terri L
TL
Young
Tin
T
Aung
Mark
M
Seielstad
Yik-Ying
YY
Teo
Young Jin
YJ
Kim
Jong-Young
JY
Lee
Bok-Ghee
BG
Han
Daehee
D
Kang
Chien-Hsiun
CH
Chen
Fuu-Jen
FJ
Tsai
Li-Ching
LC
Chang
S-J Cathy
SJ
Fann
Hao
H
Mei
Dabeeru C
DC
Rao
James E
JE
Hixson
Shufeng
S
Chen
Tomohiro
T
Katsuya
Masato
M
Isono
Toshio
T
Ogihara
John C
JC
Chambers
Weihua
W
Zhang
Jaspal S
JS
Kooner
Eva
E
Albrecht
Kazuhiko
K
Yamamoto
Michiaki
M
Kubo
Yusuke
Y
Nakamura
Naoyuki
N
Kamatani
Norihiro
N
Kato
Jiang
J
He
Yuan-Tsong
YT
Chen
Yoon Shin
YS
Cho
E-Shyong
ES
Tai
Toshihiro
T
Tanaka
D044466:Asian People / Q000235:genetics*; D001806:Blood Urea Nitrogen; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005919:Glomerular Filtration Rate / Q000235:genetics; D006801:Humans; D007668:Kidney / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D051436:Renal Insufficiency, Chronic / Q000235:genetics; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D003404:Creatinine