[Hypocretin disturbance and sleep disorders].
The hypothalamic hypocretin (orexin) system plays a crucial role in the regulation of sleep and wakefulness. The strongest evidence is the fact that the primary sleep disorder narcolepsy is caused by disrupted hypocretin signaling in humans as well as in various animal models. Today there is growing interest in the role of hypocretin defects in sleep disorders associated with neurodegenerative diseases. One of the most controversial issues is the functional relevance of partial hypocretin defects in these disorders.
Neurologie, Hôpital Gui de Chauliac, 80, avenue Augustin Fliche, 34295 Montpellier cedex. mbilliard@wanadoo.fr
Michel
M
Billiard
D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009422:Nervous System Diseases / Q000503:physiopathology; D009479:Neuropeptides / Q000378:metabolism*; D000068797:Orexins; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D014851:Wakefulness / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins