The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population.
BACKGROUND
The SNP (rs2230500) in PRKCH (the gene encoding protein kinase C η) is associated with ischemic stroke and cerebral hemorrhage in the Chinese population, but the molecular mechanisms are not clear. The aim of the present study is to investigate the association between the SNP and atherosclerosis that is common pathological basis of ischemic stroke and cerebral hemorrhage.


RESULTS
We examined the associations of the SNP with carotid intima-media thickness (CIMT), atherosclerosis diagnosed by CIMT, and factors related with inflammation in the Beijing Child Blood Pressure Study. A total of 1190 subjects participated in the follow-up study. The SNP was genotyped by allele-specific real-time PCR assay. The SNP (rs2230500) in PRKCH was significantly associated with CIMT (in far wall of left common carotid arteries, P = 0.016; in far wall of right common carotid arteries, P = 0.012) under a recessive model after adjustment for age, gender, smoking, and hypertension. The SNP was also significantly associated with complement C3 (P = 0.012) under a dominant model after adjustment for age, gender, and high sensitivity C-reactive protein.


CONCLUSIONS
Our data provide evidence that the SNP (rs2230500) in PRKCH decreases the risk of CIMT that is a worthwhile predictor of stroke and complement system possibly mediates this process.
Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Lijun
L
Wu
Bo
B
Xi
Dongqing
D
Hou
Xiaoyuan
X
Zhao
Junting
J
Liu
Hong
H
Cheng
Xin
X
Zhou
Yue
Y
Shen
Xingyu
X
Wang
Jie
J
Mi
D000328:Adult; D044466:Asian People / Q000235:genetics*; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D002681:China; D003176:Complement C3 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011493:Protein Kinase C / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
D003176:Complement C3; D008055:Lipids; D002097:C-Reactive Protein; C081975:protein kinase C eta; D011493:Protein Kinase C