Neurodevelopmental evaluation of very low birth weight infants with transient hypothyroxinemia at corrected age of 18-24 months.
OBJECTIVE
To perform neurodevelopmental evaluation at 18 to 24 months corrected age in very low birth infants (VLBW) with transient hypothyroxinemia.


METHODS
Cohort study.


METHODS
Maternity teaching hospital.


METHODS
Premature infants who were previously evaluated for thyroid hormone values in the first weeks of life were included.


METHODS
Data of these infants who weighed <1500 g and <32 weeks of gestation were retrieved for the current study. Available subjects (n=56) were evaluated for neurodevelopmental status at 18 to 24 months of corrected age. Bayley Scales of Infant Development Second Edition (BSID II) was performed to define Mental developmental index (MDI) and Psychomotor developmental index (PDI).


RESULTS
The mean MDI and PDI scores were similar between the infants with and without transient hypothyroxinemia of prematurity (THOP) [79.9 ± 14.9 vs 70 ± 20.7, respectively (P=0.54); and 92.2 ± 16.4 vs 85.6 ± 18.9, respectively (P=0.68)]. After adjustment for gestational age and multiple prenatal, perinatal, and early and late neonatal variables, THOP was not associated with an increased risk of disabling cerebral palsy, or a reduction of MDI and PDI scores.


CONCLUSIONS
THOP may not be an important cause of problems in neurologic and mental development detected at the age of 18 to 24 months corrected age.
Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. dilekdilli2@yahoo.com
Dilek
D
Dilli
Zeynep
Z
Eras
Nesibe
N
Andiran
Ugur
U
Dilmen
Evrim Durgut
ED
Sakrucu
D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007235:Infant, Premature, Diseases / Q000503:physiopathology*; D013974:Thyroxine / Q000097:blood*
D013974:Thyroxine