Severe folate-deficiency pancytopenia.
Folate-deficiency anaemia occurs in about 4 per 100 000 people, although severe cases causing moderate pancytopenia are rarer. We present the case of a significant folate deficiency in a 50-year-old alcoholic with a background of mild liver impairment and recurrent nasal and rectal bleeding. Her blood tests showed profound macrocytic anaemia with haemoglobin 2.6 g/dl, leucopoenia with white cell count 3.2 × 10(9)/litre and thrombocytopenia with platelets 17 × 10(9)/litre. Serum folate was 0.8 ng/ml (normal 2.5-13.5 ng/ml) confirming severe deficiency. Despite these life-threatening results, the patient was stable, alert and was keen to avoid admission. Medical management of the anaemia included slow transfusion of red cells and one unit of platelets in view of haemorrhagic symptoms, two injections of vitamin B12 while awaiting assays and oral folic acid. A rapid improvement in the leucopoenia and thrombocytopenia resulted and no additional complications were encountered.
Department of Medicine, East Sussex Hospital NHS Trust, East Sussex, UK. drvclarke@yahoo.co.uk
Viktoriya
V
Clarke
Simon
S
Weston-Smith
D000748:Anemia, Macrocytic / Q000175:diagnosis / Q000628:therapy; D003131:Combined Modality Therapy; D004844:Epistaxis / Q000150:complications; D017707:Erythrocyte Transfusion; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D005494:Folic Acid Deficiency / Q000175:diagnosis* / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000150:complications; D006801:Humans; D007970:Leukopenia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D010198:Pancytopenia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D014805:Vitamin B 12 / Q000008:administration & dosage
D005492:Folic Acid; D014805:Vitamin B 12