Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.
Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as cichoriin, anthocyanins, lactucin, and Lactucopicrin. In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses. These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.
Department of Physics, Bio-Medical Physics Laboratory, Jordan University of Science & Technology (JUST), Irbid, Jordan. alakmoh@just.edu.jo
M-Ali H
MA
Al-Akhras
Khaled
K
Aljarrah
Hasan
H
Al-Khateeb
Adnan
A
Jaradat
Abdelkarim
A
Al-Omari
Amjad
A
Al-Nasser
Majed M
MM
Masadeh
Amr
A
Amin
Alaaeldin
A
Hamza
Karima
K
Mohammed
Mohammad
M
Al Olama
Sayel
S
Daoud
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D002374:Catalase / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017319:Photosensitizing Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D017319:Photosensitizing Agents; D010936:Plant Extracts; D011960:Receptors, Estrogen; D002374:Catalase; D013482:Superoxide Dismutase