Enantioselective metal/organo-catalyzed aerobic oxidative sp3 C-H olefination of tertiary amines using molecular oxygen as the sole oxidant.
An organocatalysis/copper-catalyzed asymmetric oxidative sp(3) C-H olefination reaction of tertiary amines with olefins using molecular oxygen as the sole oxidant under mild conditions was realized for the first time. This novel strategy provides an efficient and environmentally friendly way to access diversify optically active C(1)-alkene tetrahydroisoquinoline derivatives.
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.
Gen
G
Zhang
Yunxia
Y
Ma
Shoulei
S
Wang
Yaohu
Y
Zhang
Rui
R
Wang
D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D000588:Amines; D007546:Isoquinolines; D016877:Oxidants; D003300:Copper; D010100:Oxygen