Hepatoprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase preparation and their mechanisms.
High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. zw@pharm.tsu.ru
A M
AM
Dygai
V V
VV
Zhdanov
G N
GN
Zyuzkov
L A
LA
Stavrova
L A
LA
Miroshnichenko
E V
EV
Udut
T Yu
TY
Khrichkova
E V
EV
Simanina
A V
AV
Artamonov
A A
AA
Bekarev
P G
PG
Madonov
D N
DN
Kinsht
R V
RV
Gurto
A V
AV
Chaikovskiy
T S
TS
Markova
T I
TI
Fomina
L A
LA
Ermolaeva
T V
TV
Vetoshkina
T Yu
TY
Dubskaya
D000818:Animals; D004800:Enzymes, Immobilized / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006521:Hepatitis, Chronic / Q000188:drug therapy*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D036103:Nanotechnology; D051381:Rats; D017208:Rats, Wistar; D044968:Regenerative Medicine
D004800:Enzymes, Immobilized; D016179:Granulocyte Colony-Stimulating Factor; D006821:Hyaluronoglucosaminidase