6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp.
A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C(14) H(16)O(6)), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C(14)H(16)O(5)), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC(50), 16 µM) than 2 (IC(50), 150 µM), and also showed prostaglandin D(2) (PGD(2)) and leucotriene B(4) (LTB(4)) release suppression activity (IC(50), 10 µM for PGD(2) and 100 µM for LTB(4)).
School of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai, Miyage, Japan. komoda@myu.ac.jp
Toshikazu
T
Komoda
Masazumi
M
Nishikawa
D000818:Animals; D001491:Basophils / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003512:Cyclohexanones / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry*; D015230:Prostaglandin D2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats
C576384:6'-hydroxyoxosorbicillinol; D003512:Cyclohexanones; D016859:Lipoxygenase Inhibitors; C410947:oxosorbicillinol; D007975:Leukotriene B4; D008084:Lipoxygenase; D015230:Prostaglandin D2