Effects of drotaverine hydrochloride on viability of rat cultured cerebellar granulocytes.
The neurocytotoxic effect of drotaverine hydrochloride was studied in culture of rat cerebellar granulocytes. Incubation of cells with 100 and 250 μM drotaverine reduced neuronal survival to 60 and 4%, respectively.
Laboratory of Peptide Chemistry, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences, Moscow, Russia. vpdem@ibch.ru
V P
VP
Demushkin
E V
EV
Zhavoronkova
L G
LG
Khaspekov
D000818:Animals; D000831:Animals, Newborn; D002470:Cell Survival / Q000187:drug effects; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D010208:Papaverine / Q000009:adverse effects / Q000031:analogs & derivatives*; D010276:Parasympatholytics / Q000009:adverse effects*; D061251:Primary Cell Culture; D051381:Rats
D010276:Parasympatholytics; C005317:drotaverin; D010208:Papaverine