Prednisolone for repeated implantation failure associated with high natural killer cell levels.
Women with unexplained repeated IVF failure present a considerable challenge. Some cases are believed to be due to immunological dysfunction preventing effective embryo implantation. As data are still being collected, doctors are faced with the dilemma of treating patients (or not) in the absence of randomised control trial evidence. This review explores a pragmatic approach in using natural killer cell analysis as a means of targeting suitable patients who might attempt treatment with additional immunosuppressive therapy.
University of New South Wales, Australia.
M
M
Krigstein
G
G
Sacks
D000022:Abortion, Spontaneous / Q000276:immunology / Q000517:prevention & control*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic
D000893:Anti-Inflammatory Agents; D011239:Prednisolone