[Rheumatic heart disease: future prospects].
Acute rheumatic fever develops after an inadequate immune response to throat streptococcal infection that induces the production of antibodies reacting against cardiac endothelial cells. Valve damage may lead to irreversible cardiac valve sequela (rheumatic heart disease) with further evolution towards severe valve dysfunction and heart failure. The disease has been almost eradicated in Western countries with the development of living conditions and prevention policies, including primary prevention (treatment of sore throats) and secondary prevention (long term administration of antibiotics). However, rheumatic heart disease remains a major health problem in developing countries. Recently, echocardiography identified children with mild features of the disease, thereby allowing early treatment.
Paris-centre de recherche cardiovasculaire, Paris, France. mariana.mirabel@inserm.fr
Mariana
M
Mirabel
Beatriz
B
Ferreira
Daniel
D
Sidi
Matthias
M
Lachaud
Xavier
X
Jouven
Eloi
E
Marijon
D002309:Cardiology / Q000639:trends*; D004452:Echocardiography / Q000706:statistics & numerical data; D005843:Geography; D006801:Humans; D008403:Mass Screening / Q000379:methods; D008954:Models, Biological; D012214:Rheumatic Heart Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D012219:Rheumatology / Q000639:trends*