Hypophosphataemia-inducing mesenchymal tumour in the foot.
Tumour-induced (or oncogenic) osteomalacia is a paraneoplastic syndrome characterised by progressive fatigue, muscle weakness, bone pain, non-healing and recurrent fractures caused by mesenchymal tumours that secrete proteins that inhibit renal phosphate transport and 1α-hydroxylation of 25-OH-vitamin D. The potentially curative treatment of choice is complete surgical excision of the tumour.
Praxis, Muri, Switzerland. christa.bauer@hin.ch
Christa
C
Bauer
Rolf
R
Brücker
Stefan
S
Bützberger
Christoph
C
Schmid
D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000368:Aged; D005260:Female; D005528:Foot / Q000473:pathology*; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D017674:Hypophosphatemia / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009372:Neoplasms, Connective Tissue / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D010018:Osteomalacia; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000175:diagnosis; D010257:Paraneoplastic Syndromes; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies