Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families.
Natural L-homocysteine and L,L-cystathionine, along with a series of unnatural analogues, have been prepared from L-aspartic and L-glutamic acid. Manipulation of the protected derivatives provided ω-iodoamino acids, which were used in thioalkylation reactions of sulfur nucleophiles, such as the ester of L-cysteine and potassium thioacetate.
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cinthia 4, 80126 Naples, Italy. luilongo@unina.it
Luigi
L
Longobardo
Nunzia
N
Cecere
Marina
M
DellaGreca
Ivan
I
de Paola
D001224:Aspartic Acid / Q000737:chemistry; D003540:Cystathionine / Q000138:chemical synthesis* / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry; D006710:Homocysteine / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D006710:Homocysteine; D001224:Aspartic Acid; D003540:Cystathionine; D018698:Glutamic Acid