Enhanced enantioselectivity of 3-methylcyclohexanone by mixed diol host compounds.
3-Methylcyclohexanone is only partially resolved by crystallisation with a chiral diol host compound (ee 40%), but when recrystallised from an equimolar mixture of the chiral diol host and a similar but achiral host we obtain complete resolution. The latter host acts as a nucleation inhibitor and the enhanced resolution is attributed to kinetic effects.
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. Luigi.Nassimbeni@uct.ac.za
Luigi R
LR
Nassimbeni
Hong
H
Su
Tanith-Lea
TL
Curtin