Feto-maternal vitamin D status and infant whole-body bone mineral content in the first weeks of life.
OBJECTIVE
Compromised vitamin D status is common in pregnancy and may have adverse impacts on fetal development. The purpose of this study was to investigate the association of infant whole-body bone mineral content (WBBMC) at 8-21 days of age with feto-maternal vitamin D status in a multiethnic population in Oakland, California.


METHODS
This was a cross-sectional study of 120 women and their newborn infants. Maternal and cord blood were collected at delivery. WBBMC was measured by dual-energy X-ray absorptiometry in term-born infants 8-21 days post birth.


RESULTS
No significant association was observed between unadjusted or size-adjusted WBBMC and feto-maternal vitamin D status analyzed continuously or categorically. In multivariate modeling, unadjusted WBBMC was predicted by bone area (P<0.0001), weight-for-age (P<0.0001) and weight-for-length (P=0.0005) Z-scores, but not by feto-maternal vitamin D status. Anthropometric predictors but not vitamin D remained significant in the multivariate model after adjustment of WBBMC for weight, bone area (bone mineral density) or logarithmically derived exponents of the denominators.


CONCLUSIONS
Results of the present study do not support an association between feto-maternal vitamin D status and early infant WBBMC, raw or adjusted for inter-individual differences in size, in a multiethnic population in Northern California.
Allen Lab, USDA, ARS Western Human Nutrition Research Center, Davis, CA 95616, USA. daphnadror@gmail.com
D K
DK
Dror
J C
JC
King
D J
DJ
Durand
E B
EB
Fung
L H
LH
Allen
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002140:California; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy / Q000378:metabolism*; D012044:Regression Analysis; D014807:Vitamin D / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
D014807:Vitamin D