Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations.
We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties.
Department of Chemistry and Biochemistry, Institute of Biosciences, UNESP-University of State of São Paulo, Unesp Botucatu, SP, Brazil. seiva.fabio@gmail.com
Fábio R F
FR
Seiva
Luiz Gustavo A
LG
Chuffa
Camila Pereira
CP
Braga
João Paulo A
JP
Amorim
Ana Angélica H
AA
Fernandes
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose; D001798:Blood Proteins / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D012970:Sodium Glutamate / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D011794:Quercetin; D012970:Sodium Glutamate