Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins.
Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the "beta branch" forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, USA.
Marcy J
MJ
Balunas
Manuel F
MF
Grosso
Francisco A
FA
Villa
Niclas
N
Engene
Kerry L
KL
McPhail
Kevin
K
Tidgewell
Laura M
LM
Pineda
Lena
L
Gerwick
Carmenza
C
Spadafora
Dennis E
DE
Kyle
William H
WH
Gerwick
D000977:Antiparasitic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007893:Leishmania donovani / Q000187:drug effects*; D008386:Marine Biology; D015394:Molecular Structure; D054300:Oscillatoria / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000977:Antiparasitic Agents; D007783:Lactones; D061065:Polyketides