Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production.
Filamentous microorganisms are important work horses in industrial biotechnology and supply enzymes, antibiotics, pharmaceuticals, bulk and fine chemicals. Here we highlight recent findings on the use of microparticles in the cultivation of filamentous bacteria and fungi, with the aim of enabling a more precise control of their morphology towards better production performance. First examples reveal a broad application range of microparticle based processes, since multiple filamentous organisms are controllable in their growth characteristics and respond by enhanced product formation.
Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaußstraße 17, Braunschweig, Germany. robert.walisko@tu-braunschweig.de
Robert
R
Walisko
Rainer
R
Krull
Jens
J
Schrader
Christoph
C
Wittmann
D001419:Bacteria / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D005658:Fungi / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D007218:Industrial Microbiology / Q000379:methods*; D008863:Microspheres