Lack of association of CYP1A1-MspI  SNP   and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence.
Research  has shown that genetic polymorphisms in biotransformation enzymes, such as  CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various  cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null  genotypes in a family group (71 members) related by consanguinity who had an  unusually high incidence of cancer and a high frequency of smokers. There were  no significant differences in genotype frequencies in this family when compared  to data for Brazilian populations. Possibly, the high incidence of cancer in  this sample is associated with smoking and/or other factors not detected in  this survey.
Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Campus Universitário do Araguaia, Barra do Garças, MT, Brasil.
L N
LN
Moraes
M F
MF
Borges
P A C
PA
Sousa
P C
PC
Venere
I L
IL
Souza
D001938:Brazil; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase