Activities of daily living in progressive non-fluent aphasia, logopenic progressive aphasia and Alzheimer's disease.
OBJECTIVE
This study examined functional changes in progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA) and Alzheimer's disease (AD) and the association between function, cognition and behaviour.


METHODS
59 patients were assessed with the Disability Assessment of Dementia (DAD), Addenbrooke's Cognitive Examination Revised (ACE-R) and the Cambridge Behavioural Inventory Revised (CBI-R).


RESULTS
No differences between groups in basic and instrumental activities of daily living (ADLs), and total ACE-R scores were found; there were correlations between total DAD and ACE-R scores for PNFA and LPA. Over 12 months, PNFA showed the marked decline of basic ADLs, whereas all three groups showed marked decline of instrumental ADLs.


CONCLUSIONS
PNFA, LPA and AD appear functionally similar when matched for disease duration. The rate of decline of ADLs depends, however, on disease diagnosis.
Neuroscience Research Australia, Sydney, Australia.
J
J
Jang
N
N
Cushing
L
L
Clemson
J R
JR
Hodges
E
E
Mioshi
D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D000849:Anomia / Q000209:etiology / Q000503:physiopathology; D001037:Aphasia / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D057178:Primary Progressive Nonfluent Aphasia / Q000503:physiopathology*