Phenolic alkaloids from the aerial parts of Dracocephalum heterophyllum.
Chemical examination of aerial parts of Dracocephalum heterophyllum resulted in isolation of phenolic alkaloids, including two flavonoidal alkaloids, drahebephins A and B, one imidazole alkaloid with a phenolic substituent, drahebenine, together with 15 other known compounds. Their structures were established by extensive spectroscopic data analyses. Due to the stereogenic center in the pyrrolidin-2-one ring, the flavonoidal alkaloids are chiral, although they were isolated as racemates. The enantiomers were separated by HPLC using a chiral phase and stereochemically characterized by circular dichroism (CD) spectroscopy. The structure of compound drahebenine was established by X-ray crystallography.
Department of Natural Products Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan, PR China.
Limei
L
Wang
Shuqi
S
Wang
Shuang
S
Yang
Xiaojiang
X
Guo
Hongxiang
H
Lou
Dongmei
D
Ren
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D019686:Lamiaceae / Q000737:chemistry*; D019800:Phenol / Q000737:chemistry*; D035261:Plant Components, Aerial / Q000737:chemistry*
D000470:Alkaloids; D019800:Phenol