Successful treatment of methimazole-induced severe aplastic anaemia in a diabetic patient with other co-morbidities.
A 55-year-old Filipina with Grave's disease, diabetes, hypertension, bronchial asthma, Parkinson's disease and a history of adverse drug reaction to penicillin consulted due to high-grade fever and sore throat. Patient was diagnosed with aplastic anaemia secondary to methimazole and was treated with high-dose granulocyte colony stimulating factor, thrombopoietin and mesterolone. Antibiotics used included levofloxacin, clindamycin, amikacin and fluconazole. Due to bleeding and slow recovery of blood parameters, 30 units of platelets and 7 units of packed red blood cells were transfused during her 22-day admission. This case presents a life-threatening adverse drug reaction in a patient with co-morbid conditions that complicate recovery and limit one's therapeutic options.
Medicine Department, University of the Philippines Philippine General Hospital, Manila, Philippines. josolcindy@yahoo.co006D
Cindy V
CV
Josol
Myrna
M
Buenaluz-Sedurante
Mark Anthony
MA
Sandoval
Gerry
G
Castillo
D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000188:drug therapy*; D013956:Antithyroid Agents / Q000009:adverse effects*; D048909:Diabetes Complications / Q000139:chemically induced* / Q000150:complications; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D008875:Middle Aged; D012074:Remission Induction; D012720:Severity of Illness Index
D013956:Antithyroid Agents; D008713:Methimazole