Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.
A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.
Institute of Inorganic Chemistry of the University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria. vladimir.arion@univie.ac.at
Vladimir B
VB
Arion
Anatolie
A
Dobrov
Simone
S
Göschl
Michael A
MA
Jakupec
Bernhard K
BK
Keppler
Peter
P
Rapta
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D001552:Benzazepines / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D003497:Cyclic N-Oxides / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D009992:Osmium / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D000970:Antineoplastic Agents; D001552:Benzazepines; D056831:Coordination Complexes; D003497:Cyclic N-Oxides; D005609:Free Radicals; C547599:paullone; D009992:Osmium; D012428:Ruthenium; C003959:TEMPO