Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines.
Contamination of feeds with mycotoxins is a worldwide problem and mycotoxin-detoxifying agents are used to decrease their negative effect. The European Food Safety Authority recently stated guidelines and end-points for the efficacy testing of detoxifiers. Our study revealed that plasma concentrations of deoxynivalenol and deepoxy-deoxynivalenol were too low to assess efficacy of 2 commercially available mycotoxin-detoxifying agents against deoxynivalenol after 3 wk of continuous feeding of this mycotoxin at concentrations of 2.44±0.70 mg/kg of feed and 7.54±2.20 mg/kg of feed in broilers. This correlates with the poor absorption of deoxynivalenol in poultry. A safety study with 2 commercially available detoxifying agents and veterinary drugs showed innovative results with regard to the pharmacokinetics of 2 antibiotics after oral dosing in the drinking water. The plasma and kidney tissue concentrations of oxytetracycline were significantly higher in broilers receiving a biotransforming agent in the feed compared with control birds. For amoxicillin, the plasma concentrations were significantly higher for broilers receiving an adsorbing agent in comparison to birds receiving the biotransforming agent, but not to the control group. Mycotoxin-detoxifying agents can thus interact with the oral bioavailability of antibiotics depending on the antibiotic and detoxifying agent, with possible adverse effects on the health of animals and humans.
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Ann.Osselaere@ugent.be
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Osselaere
M
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Devreese
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A
Watteyn
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Vandenbroucke
J
J
Goossens
V
V
Hautekiet
M
M
Eeckhout
S
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De Saeger
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De Baere
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P
De Backer
S
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Croubels
D000658:Amoxicillin / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001646:Bile / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004435:Eating / Q000187:drug effects; D005060:Europe; D005260:Female; D008297:Male; D010118:Oxytetracycline / Q000009:adverse effects / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000517:prevention & control; D014255:Trichothecenes / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism
D000900:Anti-Bacterial Agents; D014255:Trichothecenes; D000658:Amoxicillin; C048238:deepoxy-deoxynivalenol; C007262:deoxynivalenol; D010118:Oxytetracycline