Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells.
As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors lacking wt p53, this phenomenon can be exploited to protect normal cells from chemotherapy because all normal cells have wt p53. Also, several therapeutic paradigms can be reassessed, including the role of cellular senescence in cancer therapy.
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA. blagosklonny@oncotarget.com
Mikhail V
MV
Blagosklonny
D000818:Animals; D004317:Doxorubicin / Q000494:pharmacology*; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D047368:Tumor Burden / Q000187:drug effects*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53; D004317:Doxorubicin