Peptides tissue-specifically stimulate cell differentiation during their aging.
We verified expression of CXCL12 and Hoxa3 transcription factors of differentiation in cultures of human embryonic pancreatic and bronchial cells and CXCL12 and WEGC1 factors in a culture of human prostatic fibroblasts. Reduced expression of these differentiation markers was detected in late-passage (aging) cultures. The expression of differentiation factors CXCL12, Hoxa3, and WEGC1 was tissue-specifically stimulated by short peptides: pancragen (Lys-Glu-Asp-Trp) in pancreatic cells, bronchogen (Ala-Glu-Asp-Leu) in bronchial epithelial cells, and vesugen (Lys-Glu-Asp) in fibroblasts. The inducing effect of peptides on the expression of differentiation factors was more pronounced in aged cultures, which can serve as a mechanism of their geroprotective effect.
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
V Kh
VKh
Khavinson
N S
NS
Linkova
V O
VO
Polyakova
O V
OV
Kheifets
S I
SI
Tarnovskaya
I M
IM
Kvetnoy
D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects*; D054377:Chemokine CXCL12 / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides
D054377:Chemokine CXCL12; C489832:HOXA3 protein, human; D018398:Homeodomain Proteins; D009842:Oligopeptides; D010455:Peptides; C533570:lysyl-glutamyl-aspartic acid; C531938:lysyl-glutamyl-aspartyl-tryptophanamide