A highly selective fluorescence sensor for Tin (Sn4+) and its application in imaging live cells.
A naphthalimide-rhodamine B derivative was synthesized as a fluorescence turn-ON chemodosimeter for Sn(4+). A colour change and marked enhancement of fluorescence was found in the presence of Sn(4+), Cu(2+) and Cr(3+) due to the ring open reaction of rhodamine and a fluorescence resonance energy transfer process. Addition of the strong chelating agent ethylenediaminetetraacetic acid disodium salt (EDTA) partly released the cation from the complex with Sn(4+) and restored the yellow fluorescence. In addition, the compound can be used as a fluorescent probe for Sn(4+) in biological systems and may act as a tool with which to study the physiological functions of tin or pathogenesis in the human body.
Department of Chemistry, Fudan University, Shanghai, China.
Qi
Q
Wang
Chunyan
C
Li
Ying
Y
Zou
Haoxuan
H
Wang
Tao
T
Yi
Chunhui
C
Huang
D002470:Cell Survival; D002614:Chelating Agents / Q000737:chemistry; D003124:Colorimetry / Q000379:methods; D004492:Edetic Acid / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D053644:Naphthalimides / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014001:Tin / Q000032:analysis*
D002614:Chelating Agents; D005456:Fluorescent Dyes; D053644:Naphthalimides; D012235:Rhodamines; D014001:Tin; D004492:Edetic Acid; C029773:rhodamine B