Terminal ileum neuroendocrine incidentaloma in a patient with sporadic medullary thyroid carcinoma: findings from 18F-FDOPA PET/CT investigation.
An incidentaloma is a mass lesion incidentally found, of uncertain significance, and clinically inert. Although incidentaloma is commonly referred to designate an adrenal lesion, it can denote any incidental lesion of other organs. We describe the unexpected finding of an ileum neuroendocrine incidentaloma detected by 6-L-(18F)-fluorodihydroxyphenylalanine (FDOPA) PET/CT performed in an asymptomatic patient with history of sporadic medullary thyroid carcinoma and biochemical suspicion of recurrent disease. This report underlines the high FDOPA PET/CT sensitivity for neuroendocrine tumor detection and the need of complementary diagnostic investigations elucidating the significance of extraphysiological FDOPA intestinal uptake, even in patients with unrelated primary cancer.
Service de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires deStrasbourg, Strasbourg, France. alessio.imperiale@chru-strasbourg.fr
Alessio
A
Imperiale
Edmond
E
Rust
Cyrielle
C
Boulanger
Marie-Noelle
MN
Roedlich
Jean-Claude
JC
Ollier
Olivier
O
Schneegans
D018278:Carcinoma, Neuroendocrine; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D033162:Incidental Findings; D008875:Middle Aged; D064847:Multimodal Imaging; D018358:Neuroendocrine Tumors / Q000150:complications* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D013964:Thyroid Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine