New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis.
Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2'-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on (13)C- and (1)H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.
Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Syed Mustafa
SM
Ghanadian
Abdul Majid
AM
Ayatollahi
Suleiman
S
Afsharypuor
Shaghayegh Haghjooy
SH
Javanmard
Nasim
N
Dana
D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology*
D004224:Diterpenes; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A