Low-grade gliomas: when and how to treat.
Low-grade gliomas are uncommon tumors whose optimal management remains to be determined. Although well-designed clinical trials have been mounted to address certain aspects of postoperative radiotherapeutic management, additional studies are required to refine management based on tumor-specific and patient-specific variables. There is mounting evidence that the relative completeness of surgical resection can improve survival, and the molecular and histopathologic characterization of the glioma requires adequate samples for analysis. Current imaging and operative techniques can direct surgical resection, and the same imaging techniques can help monitor patients postoperatively and predict prognosis.
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Sacit Bulent
SB
Omay
Joseph M
JM
Piepmeier
Jonathan P S
JP
Knisely
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D003952:Diagnostic Imaging; D005910:Glioma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D060787:Neoplasm Grading