Dietary calcium induced cytological and biochemical changes in thyroid.
Certain epidemiological studies revealed correlation between hard water consumption (with high calcium) and thyroid size of the population, though the possible alterations in thyroid physiology upon calcium exposure are still inconclusive. Adult male Wistar strain rats were subjected to calcium treatment at the doses of 0.5g%, 1.0g% and 1.5g% calcium chloride (CaCl(2)) for 60 days. The parameters studied were - thyroid gland weight, histopathology, histomorphometry; thyroid peroxidase (TPO), 5'-deiodinase I (DI), sodium-potassium adenosine triphosphatase (Na(+)-K(+)-ATPase) activities; serum total and free thyroxine (tT4, fT4), total and free triiodothyronine (tT3, fT3), thyroid stimulating hormone (TSH) levels. Enlargement of thyroid with hypertrophic and hyperplastic changes, retarded TPO and 5'-DI but enhanced Na(+)-K(+)-ATPase activities, augmented serum total and free T4 and TSH but decreased total and free T3 levels and low T3/T4 ratio (T3:T4) were observed in the treated groups. All these findings indicate development of goitrogenesis upon exposure to excessive dietary calcium.
Endocrinology & Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, Kolkata, West Bengal, India. Electronic address: physiology.ac@gmail.com.
Amar K
AK
Chandra
Endocrinology & Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, Kolkata, West Bengal, India. Electronic address: hgoswami2007@rediffmail.com.
Haimanti
H
Goswami
Endocrinology & Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, Kolkata, West Bengal, India. Electronic address: sunny_pallav_1984@yahoo.co.in.
Pallav
P
Sengupta
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology*; D002136:Calcium, Dietary / Q000494:pharmacology*; D007453:Iodide Peroxidase / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D002136:Calcium, Dietary; D014284:Triiodothyronine; D013972:Thyrotropin; D007453:Iodide Peroxidase; D000254:Sodium-Potassium-Exchanging ATPase; D002122:Calcium Chloride; D013974:Thyroxine