Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense.
The effects of complex extract from Aconitum baikalense on reparative regeneration of a plane dorsal skin wound were studied. Treatment with Aconitum baikalense tincture stimulated reparation and skin regeneration. The effects of the Aconitum baikalense alkaloids on functional activity of fibroblast precursors were studied in vitro by cultural methods. Mesaconitine, hypaconitine, songorine, napelline, and 12-epinapelline N-oxide significantly stimulated the growth of colonies from fibroblast precursors. This indicated direct stimulation of fibroblasts by aconite alkaloids, which could be a mechanism of reparative activity of the complex extract.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. nesyuliya@yandex.ru
Yu V
YV
Nesterova
T N
TN
Povetieva
N I
NI
Suslov
V V
VV
Zhdanov
T Yu
TY
Hrichkova
E V
EV
Udut
A S
AS
Chaykovskiy
N N
NN
Gaydamovich
T I
TI
Andreeva
A M
AM
Dygai
D000157:Aconitine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D012867:Skin / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000470:Alkaloids; D010936:Plant Extracts; C109326:napelline; C058309:hypaconitine; C019470:mesaconitine; C057217:songorine; D000157:Aconitine