Dearomatizing conversion of pyrazines to 1,4-dihydropyrazine derivatives via transition-metal-free diboration, silaboration, and hydroboration.
Pyrazines and substituted pyrazines undergo addition of boron reagents having B-B, Si-B, and H-B bonds under transition-metal-free conditions, leading to high-yield synthesis of N-borylated 1,4-dihydropyrazines and 1,2,3,4-tetrahydropyrazine.
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
Kazuyuki
K
Oshima
Toshimichi
T
Ohmura
Michinori
M
Suginome