Predictors of postoperative antimuscarinics in women with mixed urinary incontinence after transobturator surgery.
OBJECTIVE
The study sought to identify the risk factors of postoperative use of antimuscarinics after transobturator surgery in women with mixed urinary incontinence (MUI) displaying both urodynamic stress urinary incontinence (SUI) and involuntary detrusor contraction (IDC) with leakage in urodynamic study.


METHODS
The clinical data of 103 patients with MUI who underwent transobturator tape (TOT) sling surgery were retrospectively reviewed. The patients were followed at least a year. To determine risk factors for postoperative use of antimuscarinics, variables of only those with P values < 0.05 on univariate analysis were included in the multivariate logistic regression analysis with forward stepwise building.


RESULTS
Eight-four (81.6 %) of 103 patients were included in this study. The cure rate of urge urinary incontinence (UUI) was 69.0 % (58/84). Antimuscarinics were prescribed postoperatively in 22 (26.2 %) of 84 patients. Variables affecting postoperative use of antimuscarinics were age, parity, episode of any UUI, preoperative use of antimuscarinics, predominant urgency incontinence type, detrusor pressure at maximum flow, and Urogenital Distress Inventory 6. Increasing age and preoperative use of antimuscarinics increased the odds of postoperative use of antimuscarinics following TOT surgery.


CONCLUSIONS
Patients who were older and had taken antimuscarinics preoperatively were significantly associated with postoperative use of antimuscarinics.
Department of Obstetrics and Gynecology, Kung Hee University Hospital at Gangdong, Kyung Hee University Medical College, Sang-Il Dong, Gangdong-Gu, Seoul 134-727, Korea. yooe7@khu.ac.kr.
Eun-Hee
EH
Yoo
Donguk
D
Kim
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D053825:Suburethral Slings; D053201:Urinary Bladder, Overactive / Q000503:physiopathology / Q000601:surgery*; D014549:Urinary Incontinence / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology
D018727:Muscarinic Antagonists