[Non-alkaloid chemical constituents from Coptis chinensis].
OBJECTIVE
To separate and identify chemical constituents from Coptis chinensis.


METHODS
The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of their physicochemical properties using spectral techniques such as NMR and MS.


RESULTS
Thirteen compounds were separated from ethanol extracts of C. chinensis, including seven lignans, three simple phenylpropanoids, two flavones and one phenolic acid, and identified as erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), (+)-pinoresinol (3), (+)-medioresinol (4), (+)-lariciresinol (5), (+)-5'-methoxylariciresinol (6), (+)-isolariciresinol (7), chlorogenic acid (8), ferulic acid (9), Z-octadecyl caffeate (10), rhamnetin (11), wogonin (12), and vanillic acid (13).


CONCLUSIONS
Compounds 1, 2, 4, 6, 10-13 were separated from the genus Coptis for the first time.
Institute of Traditional Chinese Medicine and Natural Products & Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China. cliang769@163.com
Liang
L
Chen
Lei
L
Wang
Qingwen
Q
Zhang
Shengyuan
S
Zhang
Wencai
W
Ye
D002109:Caffeic Acids / Q000737:chemistry; D002726:Chlorogenic Acid / Q000737:chemistry; D039323:Coptis / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry; D047309:Flavones / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D062385:Hydroxybenzoates / Q000737:chemistry; D017705:Lignans / Q000737:chemistry; D008031:Lignin / Q000737:chemistry; D009284:Naphthols / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry; D014641:Vanillic Acid / Q000737:chemistry
D002109:Caffeic Acids; D003373:Coumaric Acids; D044950:Flavanones; D047309:Flavones; D005663:Furans; D062385:Hydroxybenzoates; D017705:Lignans; D009284:Naphthols; C517789:octadecyl caffeate; D002726:Chlorogenic Acid; D000431:Ethanol; C060284:isolariciresinol; C063423:rhamnetin; C060282:lariciresinol; D008031:Lignin; D011794:Quercetin; C004999:ferulic acid; D014641:Vanillic Acid; C017616:phenolic acid; C085514:wogonin; C103298:pinoresinol