Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development.
FGF (fibroblast growth factor)/FGFR (FGF receptor) signalling plays an essential role in both endochondral and intramembranous bone development. FGF signalling pathways are important for the earliest stages of limb development and throughout skeletal development. The activity and the outcome of this signalling pathway during bone development are also influenced by many other intracellular and extracellular signals. In this review, we focus on the interplay between FGF signalling and other pathways, which is tightly regulated both spatially and temporally during endochondral skeletal development.
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China.
Min
M
Jin
Xiaolan
X
Du
Lin
L
Chen
D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D016207:Cytokines; D053823:Hedgehog Proteins; D017468:Receptors, Fibroblast Growth Factor; D051153:Wnt Proteins; D005346:Fibroblast Growth Factors; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt