Epigenetic mechanisms governing the process of neurodegeneration.
Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.
Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. irfan@jhu.edu
Irfan A
IA
Qureshi
Mark F
MF
Mehler
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D006655:Histone Deacetylases / Q000502:physiology; D006657:Histones / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D022661:RNA, Untranslated / Q000235:genetics
D006657:Histones; D022661:RNA, Untranslated; D006655:Histone Deacetylases