Antifibrotic and anti-inflammatory activity of a neuroleptic drug on the model of pulmonary fibrosis.
The effect of course treatment with neuroleptic haloperidol on the inflammatory response and state of the connective tissue in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fibrosis induced by intratracheal administration of bleomycin. This neuroleptic decreased the inflammatory response and reduced the growth of the connective tissue in the lungs. The anti-inflammatory effect of haloperidol is related to a decrease in activity of bone marrow hemopoietic stem cells and committed hemopoietic precursors. The antifibrotic effect of this drug is associated with inhibition of mesenchymal precursor cells.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
A M
AM
Dygai
E G
EG
Skurikhin
T V
TV
Andreeva
O V
OV
Pershina
L A
LA
Ermolaeva
E S
ES
Khmelevskaya
V A
VA
Krupin
A M
AM
Reztsova
I E
IE
Stepanova
D000280:Administration, Inhalation; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage; D002454:Cell Differentiation / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D006220:Haloperidol / Q000008:administration & dosage*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D014150:Antipsychotic Agents; D001761:Bleomycin; D006220:Haloperidol