[Ion channel therapy of ischemic heart disease].
Basic studies have shown a variety of ion channels are involved in the pathogenesis of ischemic heart disease, including L type Ca(2+) channel, T type Ca(2+) channel, ATP-sensitive potassium channel, If (funny) channel and late Na(+) channel. Clinical studies showed that the regulation of these channels function can improve myocardial blood supply and metabolism of myocardium. What is summarized below relates to the clinical usefulness of various ion channel antagonists reviewed by a clinical cardiologist, not a basic scientist working on ion channel biology.
MACC Division of Cardiovascular Medicine, University of Florida, USA.
C Richard
CR
Conti
D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors*; D017202:Myocardial Ischemia / Q000188:drug therapy*
D002317:Cardiovascular Agents; D007473:Ion Channels