The GAP between axon pruning and repulsion.
Stereotyped axonal pruning and growth cone repulsion, modulators of neuronal connectivity, share many ligands and receptors systems. Riccomagno et al. (2012) show in Cell that common ligands can link functionally specialized downstream pathways, demonstrating that the Rac GAP β2-Chimaerin is needed in Semaphorin-mediated axonal pruning but not growth cone repulsion.
Department of Neurology, Programs in Neuroscience, Developmental and Stem Cell Biology, Institute for Regeneration Medicine, University of California-San Francisco, CA 94158, USA.
Youngshik
Y
Choe
Samuel J
SJ
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