A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P(combined) = 2.8 × 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P(combined) = 6.9 × 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P(combined) = 7.4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Kouya
K
Shiraishi
Hideo
H
Kunitoh
Yataro
Y
Daigo
Atsushi
A
Takahashi
Koichi
K
Goto
Hiromi
H
Sakamoto
Sumiko
S
Ohnami
Yoko
Y
Shimada
Kyota
K
Ashikawa
Akira
A
Saito
Shun-ichi
S
Watanabe
Koji
K
Tsuta
Naoyuki
N
Kamatani
Teruhiko
T
Yoshida
Yusuke
Y
Nakamura
Jun
J
Yokota
Michiaki
M
Kubo
Takashi
T
Kohno
D000230:Adenocarcinoma / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D034961:Antigens, Nuclear / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D000071797:Butyrophilins; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics; D000092468:Bromodomain Containing Proteins
D034961:Antigens, Nuclear; D000071797:Butyrophilins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C408263:BTNL2 protein, human; C406238:fetal Alzheimer antigen; D000092468:Bromodomain Containing Proteins