Characterisation of the intracranial pressure waveform during infusion studies by means of central tendency measure.
OBJECTIVE
In the present study an attempt was made to quantify and characterise the changes in the intracranial pressure (ICP) waveform over the wide pressure range covered during infusion studies by means of the central tendency measure (CTM). CTM is a non-linear approach using continuous chaotic modelling that summarises the degree of variability in a signal.


METHODS
CTM of the ICP wave in the lumbar subarachnoid space was analysed in 77 infusion studies performed in patients with idiopathic and secondary forms of normal pressure hydrocephalus (median age 74 years, range 22-88). Four artefact-free epochs were selected during the baseline, infusion, plateau and relaxation stages of every infusion study. The average pressure, pulse amplitude and CTM were determined for each epoch. Correlations among these parameters were explored.


RESULTS
CTM of the ICP waveform decreases, i.e. variability increases, as infusion studies progress from baseline pressure to the plateau stage. Significant correlations were found during all phases of infusion testing, except at baseline, between CTM and pressure, CTM and amplitude and pressure and amplitude. Partial correlations emphasised the relationship between CTM and amplitude. When pulse amplitude is held constant, CTM and the pressure range do not correlate.


CONCLUSIONS
Volume loading leads to increased variability of the ICP signal measured by means of CTM. This finding summarises numerically the long-established phenomenon of increasing amplitude and rounding of ICP pulses associated with ICP elevation during infusion studies. CTM could be a suitable approach to quantify and characterise the pulsatile nature of the ICP wave.
Department of Neurosurgery, University Hospital of León, León, Spain. genarotumbado@gmail.com
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Santamarta
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Abásolo
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Martínez-Madrigal
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Hornero
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000704:Analysis of Variance; D002557:Cerebrospinal Fluid Shunts; D004868:Equipment Failure; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D060186:Infusions, Spinal; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010865:Pilot Projects; D011673:Pulsatile Flow / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic; D013346:Subarachnoid Space; D014160:Transducers, Pressure