Uncommon foreign body reaction caused by botulinum toxin.
Botulinum toxin is composed of 7 botulinum toxin antigenic subtypes. It is produced by Clostridium botulinum bacterial fermentation. Several botulinum toxin subtypes are under investigation for clinical use, but only botulinum toxin type A (BTX-A) is currently approved for cosmetic use because of its clinical safety profile and efficacy. The use of BTX-A in cosmetic facial procedures is a reliable way to enhance aesthetics in the face and is becoming commonplace in oral and maxillofacial surgery. This article reports an uncommon complication after Botox injection in the upper lip, for cosmetic reasons, originating a mass in the anterior region of the maxilla, which leads to failure in orthodontic treatment. Knowledge of the site anatomy, pharmacology, and dose of BTX-A before its use in cosmetic surgery should be strengthened.
Department of Surgery and Oral Pathology, João de Barros Barreto University Hospital, Belém, Brazil.
Helder Antonio Rebelo
HA
Pontes
Flávia Sirotheau Correa
FS
Pontes
Glauber Freitas
GF
de Oliveira
Haroldo Amorim
HA
de Almeida
Douglas Magno
DM
Guimarães
Flávio Cerqueira
FC
Cavallero
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000009:adverse effects*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005152:Facial Muscles / Q000187:drug effects*; D005260:Female; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D009465:Neuromuscular Agents / Q000009:adverse effects*; D012904:Smiling
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A