Impact of norepinephrine and selective β1-adrenoceptor blockers on the growth of retinal tissue explants.
We studied the effect of norepinephrine and selective β(1)-adrenoceptor blockers on the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The test drugs produced a dose-dependent effect on cell proliferation. Norepinephrine (10(-12) M) and atenolol (10(-4) M) are shown to significantly stimulate explant growth. Combined treatment with norepinephrine (10(-12) M) and atenolol (10(-4) M) results in cumulation of their stimulatory effects. The results suggest that the retina-stimulating effect of norepinephrine is based on its interactions with other types of adrenoceptors.
Department of Experimental Physiology and Pharmacology, V. A. Almazov Federal Heart, Blood, and Endocrinology Center, Federal Agency for High-Technological Medical Care, St. Petersburg, Russia. evl1112@infran.ru
E V
EV
Lopatina
V A
VA
Penniyaynen
V A
VA
Tsyrline
D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D002642:Chick Embryo; D002645:Chickens; D008790:Metoprolol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000378:metabolism; D012160:Retina / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D058671:Adrenergic beta-1 Receptor Antagonists; D011941:Receptors, Adrenergic; D001262:Atenolol; D008790:Metoprolol; D009638:Norepinephrine