Impact of chronic ethanol intake of rat mothers on the seizure susceptibility of their immature male offspring.
The aim of present study was to examine the impact of prenatal ethanol exposure on seizure susceptibility of the offspring. Pregnant Wistar rats were compelled to drink either 10% or 20% ethanol solution, as the only drinking fluid since conception up to the weaning of their offspring at the age of 28 days. Pregnant and nursing rats of the control group drank water. Electrophysiological experiments (repeated electrical stimulation and analysis of cortical afterdischarges duration) were than performed on their immature offspring. Rat pups were tested on postnatal day 18, 25, and 35. Shortening of afterdischarges duration was observed in 18-day-old animals (mothers drank 20% ethanol) when compared with age matched controls and failure of post-ictal depression phenomenon was found in 25- and 35-day-old animals. Our findings signalize that ethanol exposure during pregnancy influences seizure susceptibility by acting on excitatory/inhibitory brain systems and this effect is dose- and age-dependent.
Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Czech Republic. vladimir.riljak@lf1.cuni.cz
Vladimir
V
Riljak
Dana
D
Maresova
Katerina
K
Jandova
Jana
J
Bortelova
Jaroslav
J
Pokorny
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004198:Disease Susceptibility / Q000139:chemically induced / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology*
D000431:Ethanol