[Resection of cholangiolocellular carcinoma successfully responding to neoadjuvant hepatic arterial infusion chemotherapy - report of a case].
A 78-year-old man who had hepatitis C was examined by computed tomography(CT)because of prostate cancer, and was found to have a liver tumor 8. 0 cm in size at S4/S8. The view of the liver tumor was enhanced by CTHA image and washed out by CTAP image. It was suspected to have invaded the RHV and MHV. The pathological examination of the liver biopsy sample revealed cholangiocellular carcinoma or cholangiolocellular carcinoma. Hepatic arterial infusion chemotherapy with gemcitabine and cisplatin was performed. The size of the tumor reduced to 6. 0 cm and the invasion to the RHV was no longer evident. Hepatic resection for the middle two segments was performed after 3 months of chemotherapy. After a histological examination of the resected specimen, the patient was given the final diagnosis of cholangiolocellular carcinoma. Over 50% of the tumor was estimated as necrosis by chemotherapy, indicating that the gemcitabine and cisplatin regimen was remarkably effective. The patient is alive with no evidence of recurrence.
Dept. of Surgery, Otsu Red Cross Hospital, Japan.
Yusuke
Y
Nakayama
Naoto
N
Nakamura
Takashi
T
Ito
Jun
J
Matsubayashi
Akitada
A
Yogo
Yoshinori
Y
Kitou
Kouichi
K
Hanamoto
Katsuaki
K
Ura
Kaoru
K
Taira
Hideaki
H
Oe
Akira
A
Yoshikawa
Akira
A
Mitsuyoshi
Shunichi
S
Ishigami
Tomoyuki
T
Shirase
Ryuichiro
R
Doi
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000601:surgery; D001706:Biopsy; D018281:Cholangiocarcinoma / Q000098:blood supply / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D006499:Hepatic Artery; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed