Thalidomide-induced acute cholestatic hepatitis: case report and review of the literature.
Drug-induced liver injury (DILI) is a leading cause of liver failure and an important safety issue in drug development. Thalidomide is nowadays used for the treatment of several conditions including multiple myeloma (MM). Several adverse effects have been described but liver toxicity was seldom reported. We describe a case of thalidomide-induced hepatitis in a man treated for MM. The clinical setting and temporal association between the start of the drug and liver injury allowed the assumption of the causative role of thalidomide. As its clinical indications expand we wish to increase awareness of a new potential side effect of thalidomide. A short review on thalidomide-induced liver injury is also presented.
Department of Gastroenterology, Hospital S João, Porto, Portugal. filipe.vboas.silva@gmail.com
Filipe
F
Vilas-Boas
Regina
R
Gonçalves
Manuel
M
Sobrinho Simões
Joanne
J
Lopes
Guilherme
G
Macedo
D000208:Acute Disease; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D000068256:Darbepoetin alfa; D003975:Diazepam / Q000627:therapeutic use; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D041781:Jaundice, Obstructive / Q000139:chemically induced* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy; D009853:Omeprazole / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications; D019338:Polypharmacy; D011239:Prednisolone / Q000008:administration & dosage; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects*
D004921:Erythropoietin; D000068256:Darbepoetin alfa; D013792:Thalidomide; D011239:Prednisolone; D009853:Omeprazole; D003975:Diazepam; D008558:Melphalan