Modeling helps in understanding antidepressants.
The clinical pharmacology of antidepressant drugs is challenging to describe because of difficulties in describing the depressed state, the time course of response to a treatment intervention, and the frequent withdrawal of patients from clinical trials. Many of these challenges were addressed in a recent article by Russu et al. in this journal.
Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. n.holford@auckland.ac.nz
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D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D010352:Patient Dropouts
D000928:Antidepressive Agents