Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice.
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
Institute of Natural Medicine, Hallym University, Chuncheon, Korea.
Yoonyi
Y
Nam
Harry
H
Jung
Sankarapandian
S
Karuppasamy
Jae-Yeon
JY
Lee
Kyung-Don
KD
Kang
Kyo-Yeol
KY
Hwang
Su-Il
SI
Seong
Jun-Gyo
JG
Suh