APOL1 variants in HIV-associated nephropathy: just one piece of the puzzle.
Considerable attention has been focused on how the APOL1/MYH9 locus determines susceptibility to focal segmental glomerulosclerosis, including HIV-associated nephropathy (HIVAN). Atta and colleagues found that homozygosity for APOL1 risk alleles was associated with many, but not all, HIVAN cases, and that APOL1 variation failed to predict characteristics of disease. Their work gives important impetus to identify other genetic and environmental factors that may provide a 'second hit' linking HIV infection to HIVAN.
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Thomas
T
Hays
Christina M
CM
Wyatt
D016263:AIDS-Associated Nephropathy / Q000235:genetics*; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000235:genetics*; D008297:Male
C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL