[Left ventricular diastolic function of patients with newly diagnosed hyperthyroidism].
OBJECTIVE
To evaluate the left ventricular diastolic function of patients with newly diagnosed hyperthyroidism.


METHODS
43 patients with newly diagnosed hyperthyroidism and 45 healthy participants were recruited to have their left ventricular diastolic function assessed with conventional echocardiography (Mitral inflow) and by indicators such as valsalva maneuver, pulmonary venous flow, Tissue Doppler imaging and Left atrial volume index (LAVI).


RESULTS
1. Hyperthyroidism patients had higher heart rate and left ventricular ejection fraction than the controls (P < 0.05). 2. There was no significant difference in LAVI (P > 0.05) between the two groups. Both groups had E/A>1. E'/A'<1 during Valsalva maneuver were found in both groups, but with significant difference (P < 0.05). The hyperthyroidism patients had significantly longer A duration than the controls (P < 0.05). 3. The hyperthyroidism patients had greater peak anterograde diastolic velocity (D), peak velociey in late diastole (Ar), duration of the Ar (Ar duration) in pulmonary venous waveforms and time difference between Ar and mitral A-wave duration (Ar -A duration) than the controls(P < 0.05). Significant difference in S/D was found between the two groups (P < 0.05). 4. Em/Am<1 and E/Em>8 was found in the patients while Em/Am>l and E/Em<8 was found in the controls (P < 0.05).


CONCLUSIONS
1. Hyperthyroidism patients have impaired Left ventricular diastolic function. 2. Combined use of pulmonary venous flow, Tissue doppler imaging and mitral inflow during Valsalva maneuver is more sensitive than conventional Doppler echocardiography for assessing diastolic dysfunction.
Department of Cardiology, West China Hospital, Sichuan University ,Chengdu 610041,China.
Xian-Chao
XC
Jing
Yang
Y
Liu
Hui
H
Huang
He
H
Huang
D000293:Adolescent; D000328:Adult; D003971:Diastole / Q000502:physiology*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult