Experimental study of structural, functional, and biochemical changes in immune organs under conditions of antitumor activity of copper nanoparticles.
The effects of copper nanoparticles on the structure and function of the immune system organs (thymus and spleen) and intensity of free radical processes in the spleens of rats with sarcoma 45 were studied. A relationship between morphological and biochemical changes and antitumor efficiency of copper nanoparticles was demonstrated.
Rostov Oncological Institute, the Ministry of Health and Social Development of the Russian Federation, Russia.
E V
EV
Shalashnaya
I A
IA
Goroshinskaya
P S
PS
Kachesova
G V
GV
Zhukova
O F
OF
Evstratova
T A
TA
Barteneva
I V
IV
Neskubina
V B
VB
Borodulin
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000138:chemical synthesis; D002374:Catalase / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006651:Histocytochemistry; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D051381:Rats; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D013160:Splenic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
D000970:Antineoplastic Agents; D005609:Free Radicals; D008315:Malondialdehyde; D003300:Copper; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase