Breaking the barrier: membrane fusion triggers innate antiviral immunity.
The sensing of viral infection by the innate immune system is dominated by the recognition of nucleic acids. New data now demonstrate that the fusion of viral and target-cell membranes leads to the activation of an immune response dependent on the adaptor STING.
Division of Infectious Diseases, Vaccine & Gene Therapy Institute of Florida, Port St. Lucie, FL, USA.
David
D
Olagnier
John
J
Hiscott
D000818:Animals; D002459:Cell Fusion; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000096:biosynthesis*; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000378:metabolism*; D000099197:STING Protein
D007370:Interferon Type I; D008565:Membrane Proteins; C532857:STING1 protein, human; D000099197:STING Protein; C530855:Sting1 protein, mouse