Sesquiterpenes from the marine red alga Laurencia composita.
Four new chamigrane derivatives, laurecomin A (1), laurecomin B (2), laurecomin C (3), and laurecomin D (4), one new naturally occurring sesquiterpene, 2,10-dibromo-3-chloro-7-chamigren-9-ol acetate (5), and three known halogenated structures, deoxyprepacifenol (6), 1-bromoselin-4(14),11-diene (7), and 9-bromoselin-4(14),11-diene (8), were isolated from the marine red alga Laurencia composita collected from Pingtan Island, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 2 was active against both brine shrimp and fungus Colletotrichum lagenarium.
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Xiao-Dong
XD
Li
Feng-Ping
FP
Miao
Xiu-Li
XL
Yin
Jia-Lin
JL
Liu
Nai-Yun
NY
Ji
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D002681:China; D020231:Colletotrichum / Q000187:drug effects; D044722:Laurencia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes