A randomized controlled trial comparing ceftriaxone with cefazolin for antibiotic prophylaxis in abdominal hysterectomy.
OBJECTIVE
To compare the effectiveness of ceftriaxone versus cefazolin for the prevention of febrile morbidity and postoperative infections among patients after abdominal hysterectomy.


METHODS
In a double-blind, randomized, controlled trial in Bangkok, Thailand, 320 patients undergoing abdominal hysterectomy between July 2008 and July 2009 were randomly assigned to receive 1g of either ceftriaxone or cefazolin intravenously in a single dose before surgery. The participants were evaluated for postoperative fever and infection for up to 4 weeks. χ(2) or Fisher exact tests were used for statistical analysis.


RESULTS
There was no significant difference between the ceftriaxone and cefazolin groups in incidence of febrile morbidity (9.4% versus 11.2%), wound infection (3.8% versus 1.9%), vaginal cuff infection (3.8% versus 1.9%), or urinary tract infection (1.9% versus 1.9%).


CONCLUSIONS
There was no difference between the use of single-dose preoperative ceftriaxone and cefazolin in preventing infectious morbidity among patients undergoing hysterectomy.
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Natacha
N
Phoolcharoen
Sumanee
S
Nilgate
Orapin
O
Rattanapuntamanee
Sompop
S
Limpongsanurak
Surasith
S
Chaithongwongwatthana
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D002437:Cefazolin / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D013785:Thailand; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D014623:Vaginal Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002437:Cefazolin