No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population.
BACKGROUND
The co-occurrence of schizophrenia and type 2 diabetes mellitus (T2DM) has been well documented. Recent genome-wide association studies and meta-analyses have shown robust associations of the solute carrier family 30 member 8 (SLC30A8) gene variants with T2DM in various populations. We examined the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han Chinese population.


METHODS
The SLC30A8 rs13266634 gene polymorphism was genotyped in 837 chronic schizophrenic and 1109 unrelated healthy controls by using a case control design. We also assessed clinical symptoms.


RESULTS
There were no significant differences in the rs13266634 genotype (χ(2)  = 1.95, df = 2, p = 0.38) and allele (χ(2)  = 0.47, df = 1, p = 0.50) distributions between the patient and control groups. There was no association between rs13266634 and clinical symptoms.


CONCLUSIONS
The SLC30A8 gene variation does not appear to contribute a genetic basis for the co-occurrence of schizophrenia and T2DM.
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China. zhangxuan2010@yahoo.com.cn
Xuan
X
Zhang
Song-Lei
SL
Guan
Zhen-Qi
ZQ
Wang
Yang
Y
You
Shi-Long
SL
Sun
Li
L
Hui
Li-Ning
LN
Miao
Yaqin
Y
Yu
Thomas R
TR
Kosten
Xiang Yang
XY
Zhang
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult; D000075703:Zinc Transporter 8
D027682:Cation Transport Proteins; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8