GSK-3β activity in the hippocampus is required for memory retrieval.
Several molecules were recently found to be important for the memory retrieval process in the hippocampus; however, the mechanisms underlying the memory retrieval remain poorly understood. GSK-3β has been implicated in the control of synaptic plasticity and memory formation. Here, we investigated the relationship between hippocampal GSK-3β activity and memory retrieval using behavioral and Western blotting methods. We found that GSK-3β was activated in the hippocampus after a retention session in the passive avoidance task. An intrahippocampal injection of the GSK-3β inhibitor, SB 216763, before the retention session blocked memory retrieval (but not reconsolidation) without affecting locomotor activity. These results suggest that GSK-3β activation would be essential for memory retrieval in the hippocampus.
Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Jin Gyu
JG
Hong
Dong Hyun
DH
Kim
Chang Hwan
CH
Lee
Se Jin
SJ
Park
Jong Min
JM
Kim
Mudan
M
Cai
Dae Sik
DS
Jang
Jong Hoon
JH
Ryu
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000502:physiology*; D000071679:Glycogen Synthase Kinase 3 beta; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008301:Maleimides / Q000494:pharmacology; D051379:Mice; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*
D007211:Indoles; D008301:Maleimides; C417521:SB 216763; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D038362:Glycogen Synthase Kinase 3