Comparison of total splenic artery embolization and partial splenic embolization for hypersplenism.
OBJECTIVE
To evaluate whether total splenic artery embolization (TSAE) for patients with hypersplenism delivers better long-term outcomes than partial splenic embolization (PSE).


METHODS
Sixty-one patients with hypersplenism eligible for TSAE (n = 27, group A) or PSE (n = 34, group B) were enrolled into the trial, which included clinical and computed tomography follow-up. Data on technical success, length of hospital stay, white blood cell (WBC) and platelet (PLT) counts, splenic volume and complications were collected at 2 wk, 6 mo, and 1, 2, 3, 4 years postoperatively.


RESULTS
Both TSAE and PSE were technically successful in all patients. Complications were significantly fewer (P = 0.001), and hospital stay significantly shorter (P = 0.007), in group A than in group B. Post-procedure WBC and PLT counts in group A were significantly higher than those in group B from 6 mo to 4 years (P = 0.001), and post-procedure residual splenic volume in group A was significantly less than that observed in group B at 1, 2, 3 and 4 years post-procedure (P = 0.001). No significant differences were observed in red blood cell counts and liver function parameters between the two groups following the procedure.


CONCLUSIONS
Our results indicate that TSAE for patients with hypersplenism not only delivers a better long-term outcome, but is also associated with lower complication rates and a shorter hospital stay than PSE.
Department of Radiology, Cancer Hospital/Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xin-Hong
XH
He
Jian-Jian
JJ
Gu
Wen-Tao
WT
Li
Wei-Jun
WJ
Peng
Guo-Dong
GD
Li
Sheng-Ping
SP
Wang
Li-Chao
LC
Xu
Jun
J
Ji
D000328:Adult; D016009:Chi-Square Distribution; D002681:China; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D007902:Length of Stay; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010976:Platelet Count; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013157:Splenic Artery / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome