Factors predisposing metastatic tumor antigen 1 overexpression in hepatitis B virus associated hepatocellular carcinoma.
OBJECTIVE
Overexpression of metastatic tumor antigen-1 (MTA-1) is suggested to be associated with frequent postoperative recurrence and poor survival of hepatocellular carcinoma (HCC) patients. In this study, we intended to determine clinical factors predisposing the overexpression of MTA-1 in patients with hepatitis B virus (HBV)-associated HCC and also examine whether MTA-1 overexpression affects the survival periods of these patients treated with curative surgical resection.


METHODS
A total of 303 patients with HBV-associated HCC who underwent curative surgical resection were subjected. The expressions of MTA-1 in HCC and surrounding non-tumor liver tissues were evaluated using the immunohistochemical method. The clinical, radiological and histological characteristics of the patients were analyzed in relation to the expression of MTA-1 to find predisposing factors of MTA-1 overexpression.


RESULTS
MTA-1 was overexpressed in 104 HCC tissues (34.3 %) and none of the surrounding non-tumor tissues. Clinically, MTA-1 overexpression was significantly associated with younger age, female gender, higher serum alpha-fetoprotein level, and Child-Turcotte-Pugh class A. Also, portal vein thrombosis, microvascular invasion, capsular invasion and poorly histological differentiation were associated with overexpression of MTA-1. The cumulative survival rates were significantly lower in patients with MTA-1 overexpression compared with those in the MTA-1 negative group (P = 0.03). In addition to the overexpression of MTA-1, the presence of microvascular or capsular invasion was a significant factor determining the poor survival of the patients with HBV-associated HCC after curative resection.


CONCLUSIONS
MTA-1 is overexpressed in patients with HBV-associated HCC of invasive nature. MTA-1 overexpression is associated with shorter survival periods of patients with HBV-associated HCC after curative resection.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea.
Young-Joo
YJ
Jin
Young-Hwa
YH
Chung
Jeong A
JA
Kim
Won Hyung
WH
Park
Danbi
D
Lee
Dong Dae
DD
Seo
Soo Hyung
SH
Ryu
Myoung Kuk
MK
Jang
Eunsil
E
Yu
Young Joo
YJ
Lee
D000328:Adult; D000367:Age Factors; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000601:surgery / Q000821:virology*; D016009:Chi-Square Distribution; D003952:Diagnostic Imaging; D005260:Female; D006515:Hepatitis B virus; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000601:surgery / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012097:Repressor Proteins / Q000378:metabolism*; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D015534:Trans-Activators; D000509:alpha-Fetoproteins / Q000378:metabolism
C089320:MTA1 protein, human; D012097:Repressor Proteins; D015534:Trans-Activators; D000509:alpha-Fetoproteins; D006655:Histone Deacetylases