[The impact of locally administrated VEGF inhibitors on vascular homeostasis--controversies concerning safety of intravitreal therapy in AMD patients].
Intravitreal vascular endothelial growth factor (VEGF) inhibitors constitutes currently the first-line treatment in neovascular age-related macular degeneration (AMD). By intravitreal application of the drug, the dosage can be kept low while maximizing its effect on choroidal neovascularization and minimizing potential adverse systemic effects. However, the eye-blood barrier is often disrupted in ophthalmic neovascular disorders and the drugs can be detected in circulating blood despite being administered as an intraocular injection. As patients with AMD constitute a high-risk population for cardiovascular events, the safety of anti-VEGF therapies must be precisely and thoroughly assessed. In the present work, the recent reports documenting systemic safety of intravitreal VEGF inhibitors have been reviewed. Moreover, the novel methods to assess the potential systemic effect on vascular homeostasis as the consequence of such therapy have been also discussed.
Katedra i Zakład Histologii i Embriologii Pomorskiego Uniwersytetu Medycznego w Szczecinie. annam@pum.edu.pl
Anna
A
Machalińska
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D000068258:Bevacizumab; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000517:prevention & control*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D058449:Intravitreal Injections; D008268:Macular Degeneration / Q000188:drug therapy*; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000009:adverse effects*
D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab