[Immunogenetics of psoriasis: update].
BACKGROUND
Psoriasis is a chronic inflammatory skin disease often benign, affecting 2-3% of the total world population. Psoriasis is a multifactorial disease.


OBJECTIVE
To present recent advances in the immunologic mechanisms and susceptibility genes involved in the pathogenesis of psoriasis.


METHODS
We presented a literature review of recent genetic and immunological basis of psoriasis to better understand the pathomecanisms of this disease and discuss the contribution of the Tunisian work in this area.


RESULTS
Recent works focalized mainly in immunology and genetics. Current progresses in molecular biology have allowed to better characterize the immunogenetic abnormalities in psoriasis.


CONCLUSIONS
Psoriasis is a multifactorial disease model in which environmental factors (psychological, climate, traumatic, infectious, and viral) seem to be triggering factors when associated with a particular immunogenetics predisposition.
Laboratoire de genetique, Immunologie et pathologie humaine, Faculte des sciences de Tunis.
Myriam
M
Ammar
Ines
I
Zaraa
Chiraz
C
Bouchlaka-Souissi
Nejib
N
Doss
Raouf
R
Dhaoui
Amel
A
Ben Osman
Mourad
M
Mokni
Amel
A
Ben Ammar El Gaaied
D006801:Humans; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*