Bioprospecting Micromonospora from Kaziranga National Park of India and their anti-infective potential.
Large number of strains was isolated from soils of Kaziranga National Park of North-East India using selective isolation procedure. They were assigned to the genus Micromonospora on the basis of their typical colonial and pigmentation features. The taxonomic identities of the isolates were confirmed on the basis of their molecular characters (16SrDNA). A total of one hundred Micromonospora strains were isolated during the present investigation. The diagnostic cell wall sugar and amino acids were determined from these Micromonospora strains. After preliminary screening most of the isolates exhibited excellent anti-infective activity against human bacterial pathogens Staphylococcus aureas, Bacillus subtilis, Proteus vulgaris, Echerichia coli, Pseudomonas aeroginosa and fungal pathogens Aspergillus niger, Fusarium oxysporum and Candida albicans. Among these isolates one strain designated as HK-10 showed promising activity against human pathogens S. aureas, B. subtilis, P. vulgaris and P. aeroginosa.
Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785006, India.
Madhumita
M
Talukdar
Aparajita
A
Duarah
Shruti
S
Talukdar
Manorama Bura
MB
Gohain
Rajal
R
Debnath
Archana
A
Yadav
Dhruva K
DK
Jha
Tarun C
TC
Bora
D000890:Anti-Infective Agents / Q000302:isolation & purification; D000898:Antibiosis; D061046:Biological Control Agents; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology*; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012988:Soil Microbiology
D000890:Anti-Infective Agents; D061046:Biological Control Agents; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S