The estrogen receptor negative-progesterone receptor positive breast carcinoma is a biological entity and not a technical artifact.
The ER-/PR+ breast tumor may be the result of a false ER negative result. The aim of this study was to investigate whether there is a difference in patient and tumor characteristics of the ER-/PR+ phenotype in an Asian setting. A total of 2629 breast cancer patients were categorized on the basis of their age, ethnicity, tumor hormonal receptor phenotype, grade and histological type. There were 1230 (46.8%) ER+/PR+, 306 (11.6%) ER+/PR-, 122 (4.6%) ER-/PR+ and 972 (37%) ER-/PR-. ER-/PR+ tumors were 2.5 times more likely to be younger than 50 years at diagnosis (OR: 2.52; 95% CI: 1.72-3.67). Compared to ER+/PR+ tumors, the ER-/ PR+ phenotype was twice more likely to be associated with grade 3 tumors (OR:2.02; 95%CI: 1.00-4.10). In contrast, compared to ER-/PR- tumors, the ER-/PR+ phenotype was 90% less likely to be associated with a grade 3 tumor (OR: 0.12; 95%CI:0.05-0.26), and more likely to have invasive lobular than invasive ductal histology (OR: 3.66; 95%CI: 1.47-9.11). These results show that the ER-/PR+ phenotype occurs in a younger age group and is associated with intermediate histopathological characteristics compared to ER+/PR+ and ER-/PR- tumors. This may imply that it is a distinct entity and not a technical artifact.
Department of Surgery, Faculty of Medicine, Julius Center University of Malaya, Malaysia. chhng@ummc.edu.my
Char Hong
CH
Ng
Nirmala Bhoo
NB
Pathy
Nur Aishah
NA
Taib
Kein Seong
KS
Mun
Anthony
A
Rhodes
Cheng Har
CH
Yip
D000367:Age Factors; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D016015:Logistic Models; D008296:Malaysia; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D010641:Phenotype; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone