Volatile anaesthetics and cardioprotection: lessons from animal studies.
Volatile anaesthetics emerged as important cardioprotective agents in both animal models of ischaemia/reperfusion injury and humans with coronary artery disease. Their administration before a prolonged ischaemic episode is known as anaesthetic preconditioning, whereas when given at the very onset of reperfusion, the strategy is termed anaesthetic postconditioning. Both types of anaesthetic conditioning reduce, albeit not to the same degree, the extent of myocardial injury. They share similar, albeit not identical, intracellular signal transduction pathways with their widely investigated counterparts, ischaemic pre- and postconditioning. Despite a wealth of preclinical evidence for cardioprotection for anaesthetic conditioning strategies, their translation into clinical therapy has been rather disappointing. This review highlights the major findings on the cardioprotective effects of volatile anaesthetics in experimental settings. It explores hypotheses that may explain the lack of efficacy observed in several past clinical studies paving the way for future preclinical and translational studies.
Department of Pathophysiology, "Victor Babeş", University of Medicine and Pharmacy of Timişoara, Timişoara, Romania. daninamuntean@umft.ro
Danina M
DM
Muntean
Valentin
V
Ordodi
René
R
Ferrera
Denis
D
Angoulvant
D000280:Administration, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D057170:Translational Research, Biomedical / Q000639:trends; D014835:Volatilization
D018685:Anesthetics, Inhalation; D020011:Protective Agents