Brain-blood barrier breakdown and pro-inflammatory mediators in neonate rats submitted meningitis by Streptococcus pneumoniae.
Neonatal meningitis is an illness characterized by inflammation of the meninges and occurring within the birth and the first 28 days of life. Invasive infection by Streptococcus pneumoniae, meningitis and sepsis, in neonate is associated with prolonged rupture of membranes; maternal colonization/illness, prematurity, high mortality and 50% of cases have some form of disability. For this purpose, we measured brain levels of TNF-α, IL-1β, IL-6, IL-10, CINC-1, oxidative damage, enzymatic defense activity and the blood-brain barrier (BBB) integrity in neonatal Wistar rats submitted to pneumococcal meningitis. The cytokines increased prior to the BBB breakdown and this breakdown occurred in the hippocampus at 18 h and in the cortex at 12h after pneumococcal meningitis induction. The time-dependent association between the complex interactions among cytokines, chemokine may be responsible for the BBB breakdown and neonatal pneumococcal severity.
Laboratório de Microbiologia Experimental e Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. tba@unesc.net
Tatiana
T
Barichello
Glauco D
GD
Fagundes
Jaqueline S
JS
Generoso
Ana
A
Paula Moreira
Caroline S
CS
Costa
Jessiele R
JR
Zanatta
Lutiana R
LR
Simões
Fabricia
F
Petronilho
Felipe
F
Dal-Pizzol
Márcia
M
Carvalho Vilela
Antonio
A
Lucio Teixeira
D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D008581:Meningitis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D011008:Pneumococcal Infections / Q000150:complications*; D051381:Rats; D013997:Time Factors
D018836:Inflammation Mediators