Peroxisome proliferator-activated receptors of trophoblast cells in miscarriage.
Comparative histological study of uterine curettage specimens in missed abortion in women with spontaneous and induced pregnancy and progressing spontaneous pregnancy revealed similar changes in the endometrium and placental villi. Immunohistochemical assay showed enhanced expression of PPARγ and increased proliferation index (Ki-67) in cells of the villous and extravillous trophoblasts in missed abortion.
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care and Social Development of the Russian Federation, Russia. N_aleksandrova@oparina4.ru
N V
NV
Alexandrova
E A
EA
Dubova
O R
OR
Baev
A I
AI
Shchegolev
G T
GT
Sukhikh
D000022:Abortion, Spontaneous / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D049109:Cell Proliferation; D002824:Chorionic Villi / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000235:genetics* / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism* / Q000473:pathology
D019394:Ki-67 Antigen; D047495:PPAR gamma