Cocrystal dissociation and molecular demixing in the solid state.
A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.
Department of Chemistry, University of Cambridge, Cambridge, UK. mde32@cam.ac.uk
Mark D
MD
Eddleston
Gareth O
GO
Lloyd
William
W
Jones