Counteractive effect of antacid suspensions on intrinsic dental erosion.
This in vitro study aimed to investigate the anti-erosive effect of antacid suspensions applied to enamel after exposure to hydrochloric acid (HCl). Ninety bovine enamel slabs were embedded, flattened, and polished. Reference areas were created and specimens were divided into six groups. They were exposed to 0.01 M HCl (pH 2) for 2 min, followed by immersion for 1 min in one of the following test suspensions: magnesium hydroxide, aluminum hydroxide, magnesium hydroxide/aluminum hydroxide, sodium alginate/sodium bicarbonate/calcium carbonate, or hydrated magnesium aluminate. Artificial saliva was used as a negative control. Specimens were subjected to a total of five cycles of erosion/antacid treatment. Enamel surface loss was measured (in micrometers) by optical profilometry. In addition, baseline and final surface microhardness (SMH) values of enamel were obtained. It was found that antacid suspensions significantly reduced enamel loss, and that similar protection was afforded by all formulations. No differences were observed between the final enamel SMH values among groups. Antacid suspensions counteracted HCl-induced enamel loss, although they were not effective in reducing enamel softening. Mouth rinsing with antacid suspensions after vomiting can potentially represent a promising strategy to counteract enamel loss caused by erosion.
São Leopoldo Mandic Research Center and Institute, Campinas, SP, Brazil. cecilia.turssi@gmail.com
Cecilia P
CP
Turssi
Lídia M F F
LM
Vianna
Anderson T
AT
Hara
Flávia L B
FL
do Amaral
Fabiana M G
FM
França
Roberta T
RT
Basting
D000704:Analysis of Variance; D000818:Animals; D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D003743:Dental Enamel / Q000187:drug effects*; D006244:Hardness / Q000187:drug effects*; D006851:Hydrochloric Acid; D012464:Saliva, Artificial; D013535:Suspensions / Q000737:chemistry; D014077:Tooth Erosion / Q000139:chemically induced / Q000517:prevention & control*
D000863:Antacids; D012464:Saliva, Artificial; D013535:Suspensions; D006851:Hydrochloric Acid