[Incidence of comorbidities in hospitalized chronic obstructive pulmonary disease patients and correlated risk factors].
OBJECTIVE
To explore the incidence of comorbidities in hospitalized chronic obstructive pulmonary disease (COPD) patients and influencing factors.


METHODS
A retrospective review of medical records was performed for 495 hospitalized COPD patients in Peking University Third Hospital from January 2003 to December 2008. Their comorbidities were identified and ranked in prevalence. The risk factors of comorbidities were analyzed by multivariable Logistic regression.


RESULTS
The most frequent comorbidities were: hypertension (60.0%), ischemic heart disease (16.0%), malignant tumor (10.9%), diabetes mellitus (10.5%), chronic heart failure (9.9%) and dyslipidemia (9.9%). The percentage of patients with ischemic heart disease in people with FEV(1)% Pred < 30%, 30% ≤ FEV(1)%Pred < 50%, 50% ≤ FEV(1)%Pred < 80% and FEV(1)%Pred ≥ 80% were 9.2%, 12.7%, 21.3% and 16.5% respectively (P = 0.052). The percentage of patients with dyslipidemia in people with FEV(1)%Pred < 30%, 30% ≤ FEV(1)%Pred < 50%, 50% ≤ FEV(1)%Pred < 80%, FEV(1)%Pred ≥ 80% were 5.3%, 5.7%, 10.9% and 20.3% respectively (P = 0.002). The percentage of patients with ischemic heart disease in people with body mass index (BMI) < 18.5, 18.5 - 23.9, 24.0 - 27.9, ≥ 28.0 kg/m(2) were 13.6%, 14.2%, 14.6% and 28.3% respectively (P = 0.051). The percentage of patients with dyslipidemia in people with BMI < 18.5, 18.5 - 23.9, 24.0 - 27.9, ≥ 28.0 kg/m(2) were 5.5%, 5.7%, 14.6% and 25.0% respectively (P = 0.000). The levels of C-reactive protein (CRP) were higher than the 75(th) percentile (OR = 2.371, P = 0.014), and complications with metabolic syndrome (OR = 2.694, P = 0.003) were independent risk factors of ischemic heart disease in COPD patients.


CONCLUSIONS
The incidence of comorbidities varies in different COPD populations. Higher levels of CRP and complications with metabolic syndrome are independent risk factors of ischemic heart disease in COPD patients.
Department of Respiratory Diseases, Peking University Third Hospital, Beijing 100191, China.
Chun
C
Chang
Wan-zhen
WZ
Yao
Tian-shu
TS
Fang
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007297:Inpatients; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors