Diphenyl diselenide protects against metabolic disorders induced by acephate acute exposure in rats.
The present study investigated the effect of diphenyl diselenide [(PhSe)2 ] on metabolic disorders induced by acephate acute exposure in rats. We also investigated a possible mechanism of action of (PhSe)2 against hyperglycemia induced by acephate. (PhSe)2 was administered to rats at a dose of 10 or 30 mg/kg by oral gavage (p.o.) 1 hour prior to acephate administration (140 mg/kg; p.o.). Glucose and corticosterone levels as well as the lipid status were determined in plasma of rats. Cardiovascular risk factors and the atherogenic index were calculated. Glycogen levels as well as tyrosine aminotransferase (TAT) and glucose-6-phosphatase (G6Pase) activities were determined in livers of rats. Cerebral acetylcholinesterase (AChE) activity was assayed. Acephate induced an increase in glucose and corticosterone levels as well as in TAT and G6Pase activities. AChE activity was inhibited by acephate. Triglyceride (TG) levels and the cardiovascular risk factor TG/high-density lipoprotein-cholesterol (HDL) were increased by acephate. (PhSe)2 was effective against the metabolic disorders induced by acephate acute exposure in rats.
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brasil.
Carmine Inês
CI
Acker
Cristina Wayne
CW
Nogueira
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D001786:Blood Glucose; D008076:Cholesterol, HDL / Q000097:blood; D003345:Corticosterone / Q000097:blood; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced / Q000188:drug therapy*; D016566:Organoselenium Compounds / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D063088:Phosphoramides / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D014444:Tyrosine Transaminase / Q000378:metabolism
D001555:Benzene Derivatives; D001786:Blood Glucose; D008076:Cholesterol, HDL; D016566:Organoselenium Compounds; D009946:Organothiophosphorus Compounds; D063088:Phosphoramides; D020011:Protective Agents; D014280:Triglycerides; C061132:diphenyldiselenide; C001969:acephate; D006003:Glycogen; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; D005952:Glucose-6-Phosphatase; D003345:Corticosterone