Peripheral bone involvement of intravascular large B-cell lymphoma on 99mTc-MDP bone scan and 18F-FDG PET/CT.
A 64-year-old man was admitted for evaluation of recently developed anemia and bone pain. The bone scan showed diffusely active lesions in the peripheral bones, symmetrically. Interestingly, 18F-FDG PET/CT revealed the hypermetabolic changes in the peripheral bones as well as the internal organs. Biopsy of bone marrow confirmed the diagnosis of intravascular B-cell lymphoma. After the 3 cycles of R-CHOP chemotherapy, 18F-FDG PET/CT showed improvement of the previous hypermetabolic lesions, suggesting good response. Intravascular B-cell lymphoma is a rare and aggressive variant of diffuse large cell lymphoma characterized by proliferation of malignant cells within the vascular lumina.
Department of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Sun Young
SY
Oh
Gi Jeong
GJ
Cheon
Eugene
E
Jeong
Sinae
S
Lee
Tae Gyu
TG
Park
Kisoo
K
Pahk
Jae-Gol
JG
Choe
D001842:Bone and Bones / Q000000981:diagnostic imaging*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
D019788:Fluorodeoxyglucose F18; D013669:Technetium Tc 99m Medronate