[Antimicrobial susceptibilityof clinical isolates of aerobic gram-negative bacteria in 2008].
We determined MICs of antibacterial agents against 1145 clinical strains of aerobic Gram-negative bacteria (22 species) isolated at 16 Japanese facilities in 2008. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum beta-lactamases (ESBL) accounted for 3.8% of Escherichia coli, 2.6% of Klebsiella pneumoniae, 6.8% of Klebsiella oxytoca, 5.5% of Proteus mirabilis and 1.8% of Proteus vulgaris. ESBL produced strains were 6.8% at K. oxytoca that increased compared with 3.2% and 5.5% at P. mirabilis that decreased compared with 18.8% in 2006. Among Haemophilus influenzae, 61.7% that decreased compared with 67.7% in 2006, equaled 58.7% in 2004, were strains when classified by penicillin-binding protein 3 mutation. Against Pseudomonas aeruginosa, the activity of most antibacterial agents was similar to that in 2006. Although two antibacterial agents that tobramycin showed an MIC90 of 1 microg/mL and doripenem showed an MIC90 of 4 microg/mL against P. aeruginosa have potent activity. Of all P. aeruginosa strains, 4.3% were resistant to six agents of nine antipseudomonal agents, that decreased compared to 12.2% in 2004 and 5.7% in 2006. Against other glucose-non-fermentative Gram-negative rods, the activity of most antibacterial agents was similar to that in 2006.
Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd.
Isamu
I
Yoshida
Takahiro
T
Yamaguchi
Reiko
R
Kudo
Rieko
R
Fuji
Choichiro
C
Takahashi
Reiko
R
Oota
Mitsuo
M
Kaku
Hiroyuki
H
Kunishima
Masahiko
M
Okada
Yoshinori
Y
Horikawa
Joji
J
Shiotani
Hiroyoshi
H
Kino
Yuka
Y
Ono
Shinichi
S
Fujita
Shuji
S
Matsuo
Hisashi
H
Kono
Seishi
S
Asari
Masahiro
M
Toyokawa
Nobuchika
N
Kusano
Motoko
M
Nose
Toshinobu
T
Hori
Ayako
A
Tanimoto
Hitoshi
H
Miyamoto
Tetsunori
T
Saikawa
Kazufumi
K
Hiramatsu
Shigeru
S
Kohno
Katsunori
K
Yanagihara
Nobuhisa
N
Yamane
Isamu
I
Nakasone
Hideki
H
Maki
Yoshinori
Y
Yamano
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D046915:Penicillin-Binding Proteins / Q000235:genetics
D000900:Anti-Bacterial Agents; D046915:Penicillin-Binding Proteins