Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy.
We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has been employed successfully in an Irish centre.
Department of Nephrology, St Vincent's University Hospital, Dublin 4. fward79@hotmail.com
F
F
Ward
O
O
Dunne
T B
TB
Crotty
D
D
Fennelly
A
A
Watson
J
J
Holian
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D001897:Boronic Acids / Q000627:therapeutic use*; D000069286:Bortezomib; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007494:Ireland; D007677:Kidney Function Tests; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D011719:Pyrazines / Q000627:therapeutic use*; D006435:Renal Dialysis / Q000379:methods*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib