Copper-catalyzed aerobic aliphatic C-H oxygenation directed by an amidine moiety.
A method for the oxygenation of tertiary C-H bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr·SMe(2)/2,2'-bipyridine catalytic system under an O(2) atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric molecular oxygen during the present process.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Yi-Feng
YF
Wang
Hui
H
Chen
Xu
X
Zhu
Shunsuke
S
Chiba