[Microsatellite markers and their application in genetic diversity research of Plasmodium spp].
Microsatellites, namely simple sequence repeats (SSR), are simple tandemly repeated sequences with repeat units of 1-6 bp in length. As genetic markers, microsatellites are abundant and distributed throughout the eukaryotic genomes. Their advantages include high polymorphism and abundance, co-dominance, selective neutrality and high reliability. In recent years, microsatellite markers are often used to study the biologically genetic diversity. In this paper, we briefly review the application of microsatellite technique in the study of Plasmodium spp. genetic diversity.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China.
Jun-Wei
JW
Li
Shui-Sen
SS
Zhou
Fang
F
Huang
D014644:Genetic Variation; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000188:drug therapy; D018895:Microsatellite Repeats; D010961:Plasmodium / Q000145:classification / Q000235:genetics*; D011110:Polymorphism, Genetic