Step-economic synthesis of (+)-crocacin C: a concise crotylboronation/[3,3]-sigmatropic rearrangement approach.
The step-economic total synthesis of (+)-crocacin C has been achieved in 20% yield from commercially available starting materials. This approach requires the isolation of only 8 intermediates and can provide a reliable supply of (+)-crocacin C for the development of new antifungal and crop protection agents.
School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Adele E
AE
Pasqua
Frank D
FD
Ferrari
Chris
C
Hamman
Yanzhou
Y
Liu
James J
JJ
Crawford
Rodolfo
R
Marquez
D000475:Alkenes / Q000138:chemical synthesis*; D000577:Amides / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001896:Boron Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D000577:Amides; D000935:Antifungal Agents; D001896:Boron Compounds; C500918:crocacin C