Solid dispersions in pharmaceutical technology. Part I. Classification and methods to obtain solid dispersions.
There are many methods to increase solubility of a substance. These include, inter alia, preparation of solid dispersions, i.e. eutectic mixtures, solid solutions, glassy solutions and suspensions. When compared to the individual constituents prior to dispersion formation solid dispersion components are better soluble in water. Therefore, solid solutions became one of the most promising ways to modify solubility, ensuring improved bioavailability and consequently therapeutic efficacy of a substance. In this part of the publication solid dispersions were classified and described in regard to their properties and preparation methods, i.e. melting method, melt evaporation and melt extrusion methods, lyophilisation technique, melt agglomeration process as well as SCF technology and electrospinning.
Department of Drug Form Technology, Wroclaw Medical University, ul. Szewska 38, Wroclaw, Poland. bozkar@ktpl.am.wroc.pl
Bozena
B
Karolewicz
Agata
A
Górniak
Sandra
S
Probst
Artur
A
Owczarek
Janusz
J
Pluta
Ewa
E
Zurawska-Płaksej
D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D005612:Freeze Drying / Q000379:methods; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry / Q000145:classification; D013535:Suspensions / Q000737:chemistry / Q000145:classification
D013501:Surface-Active Agents; D013535:Suspensions