Incidence of intussusception as studied from a hospital-based retrospective survey over a 10-year period (2001-2010) in Akita Prefecture, Japan.
One concern about rotavirus vaccines is its possible association with intussusception.  Thus, it is necessary to determine the baseline incidence for intussusception in the first year of  life in places where rotavirus vaccines are introduced. However, few safety data exist for the period  at which the first dose of Rotarix and RotaTeq are allowed to administer in Japan. The first dose of  Rotarix is scheduled to administer at 6-20 weeks of age and that of RotaTeq is scheduled to administer  at 6-24 weeks of age; the upper limits for these vaccines is later than the upper limit recommended by  the World Health Organization by 5 and 9 weeks, respectively. We performed a retrospective  cross-sectional study by reviewing medical charts of all hospitals that provided pediatric beds  in Akita Prefecture, Japan, and identifying the cases of intussusception that met the Brighton  criteria level 1 in these hospitals between January 2001 and December 2010. During this 10-year  period, 122 children younger than 1 year of age were diagnosed with intussusception. The incidence of  intussusception was estimated at 158 per 100,000 person-years among children younger than 1 year  (95% confidence interval, 131-188), 10 per 100,000 person-years for children aged 0-2 months, 165 for  children aged 3-5 months, and 300 for children aged 6-8 months. This rapid and substantial increase  in the incidence of intussusception during the first year of life should be considered when  formulating the immunization schedule for administering rotavirus vaccines in Japan.
Department of Pediatrics, Akita University Graduate School of Medicine, Akita, Japan.
Atsuko
A
Noguchi
Toyoko
T
Nakagomi
Shigeru
S
Kimura
Yoshihiro
Y
Takahashi
Kenichi
K
Matsuno
Hiromi
H
Koizumi
Arata
A
Watanabe
Hiroo
H
Noguchi
Tadahiko
T
Ito
Mihoko
M
Ohtsuka
Naoya
N
Uemura
Osamu
O
Takeda
Akira
A
Komatsu
Wataru
W
Kikuchi
Masaki
M
Komatsu
Hiroshi
H
Fukaya
Shinobu
S
Miura
Hiroyuki
H
Toda
Osamu
O
Nakagomi
Tsutomu
T
Takahashi
D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000453:epidemiology* / Q000209:etiology; D007564:Japan / Q000453:epidemiology; D012189:Retrospective Studies; D022243:Rotavirus Vaccines / Q000009:adverse effects
D022243:Rotavirus Vaccines