Metal-free oxidative trifluoromethylthiolation of terminal alkynes with CF3SiMe3 and elemental sulfur.
A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF(3)SiMe(3) and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China.
Chao
C
Chen
Lingling
L
Chu
Feng-Ling
FL
Qing
D000480:Alkynes / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
C523557:(trifluoromethyl)-trimethylsilane; D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D016877:Oxidants; D013438:Sulfhydryl Compounds; D014297:Trimethylsilyl Compounds; D013455:Sulfur