Sialyl Lewis(x): a "pre-organized water oligomer"?
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).
Institute of Molecular Pharmacy, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Florian P C
FP
Binder
Katrin
K
Lemme
Roland C
RC
Preston
Beat
B
Ernst
D002151:Calorimetry; D019040:E-Selectin / Q000737:chemistry / Q000378:metabolism*; D019277:Entropy; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D000080506:Sialyl Lewis X Antigen; D014867:Water / Q000737:chemistry / Q000378:metabolism*
D019040:E-Selectin; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D014867:Water