Changes in phospholipid composition of the spinal cord in rabbits with allergic encephalomyelitis as an experimental model of multiple sclerosis.
Qualitative and quantitative composition of phospholipids in different compartments of the spinal cord was studied in normal rabbits and in experimental model of multiple sclerosis. The content of initial and final LPO products in compartments of the rabbit spinal cord was studied during different stages of the disease. The emergence of quantitative changes in the phospholipid composition depended on the form of experimental allergic encephalomyelitis and compartment of the spinal cord. The levels of conjugated dienes and MDA increased. The maximum levels of LPO products were recorded in the lumbar and sacral compartments of the spinal cord in severe experimental allergic encephalomyelitis.
N. P. Ogarev Mordovian State University, Saransk, Russia.
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Revina
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Gromova
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Timoshina
D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism*
D010743:Phospholipids