[Influence of different solutions on extracting of active components in Danggui Chishao drug pair].
OBJECTIVE
To study the dissolution rate of active components of different extracting solvents of Danggui Chishao drug pair.


METHODS
The dissolution rates of phenolic acids (ferulic acid, vanillic acid and gallic acid), monoterpenes (gallic acid, peoniflorin, albiflorin, hydroxypeoniflorin and galloylpaeoniflorin) and phthalates (senkyunolide and ligustilide) contained in Danggui Chishao drug pair were determined by quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS) and ultra high performance liquid chromatography in combination with triple-quadrupole mass spectrometry (UPLC-TQ-MS).


RESULTS
The dissolution rates of phenolic acids and monoterpenes decreased with the increase in alcohol concentration, on the contrary the rates of phthalates increased. The relative dissolution rates of most active components were relatively high in water and low concentration alcohol than other solvents.


CONCLUSIONS
Liquid chromatography-mass spectrometry is practical for comprehensive multi-component assessment on traditional Chinese medicine preparation processes and can provide reference for optimization of processing parameters.
Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.
Wen
W
Ding
Dawei
D
Qian
Pei
P
Liu
Jin'ao
J
Duan
Erxin
E
Shang
Yuping
Y
Tang
Jing
J
Wu
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005707:Gallic Acid / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D062385:Hydroxybenzoates / Q000737:chemistry; D013058:Mass Spectrometry; D039821:Monoterpenes / Q000737:chemistry; D010795:Phthalic Acids / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D014641:Vanillic Acid / Q000737:chemistry; D006027:Glycosides
D015107:4-Butyrolactone; D001565:Benzoates; D001572:Benzofurans; D001952:Bridged-Ring Compounds; D004365:Drugs, Chinese Herbal; D005707:Gallic Acid; D005960:Glucosides; D062385:Hydroxybenzoates; D039821:Monoterpenes; D010795:Phthalic Acids; D012997:Solvents; D014641:Vanillic Acid; C015423:peoniflorin; D006027:Glycosides; C014959:albiflorin; C027820:ligustilide; C032279:phthalic acid; C045855:3-N-butyl-4,5-dihydrophthalide; C017616:phenolic acid