In vitro effects of pulmonary surfactant on macrophage morphology and function.
The effects of pulmonary surfactant on the morphology and functioning of young macrophages were studied on the model of monocyte/macrophage differentiation in vitro and on macrophages of the bronchial alveolar lavage fluid. Surfactant is not a differentiation inductor, but it stimulated the maturation and phagocytic activity of young macrophages. The stimulatory effect of surfactant on phagocytic activity of macrophages persisted even after its removal from the culture medium.
Institute of Tuberculosis, the Russian Academy of Medical Sciences, Moscow, Russia.
L N
LN
Lepekha
E A
EA
Alexandrova
M V
MV
Erokhina
D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D016676:Macrophages, Alveolar / Q000166:cytology / Q000187:drug effects*; D055017:Monocyte-Macrophage Precursor Cells / Q000166:cytology / Q000187:drug effects*; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010703:Phorbol Esters; D011663:Pulmonary Surfactants / Q000494:pharmacology*; D014397:Tuberculosis, Pulmonary / Q000473:pathology
D010703:Phorbol Esters; D011663:Pulmonary Surfactants