Matrix metalloproteinases in health and disease: insights from dermatopathology.
Matrix metalloproteinases, a group of over 26 zinc-dependent enzymes, share a similar structure to each other and functionally are capable of degrading almost every component of the extracellular matrix. They are essential to normal development during embryogenesis and extracellular matrix remodeling and, given this, understandably enough have been implicated in multiple pathologic processes that encompass the inflammatory and neoplastic spectrum of disease. This review attempts to define roles of matrix metalloproteinases of relevance in normal skin and to elucidate their roles in inflammatory dermatoses and benign and malignant neoplasms.
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Marier
M
Hernández-Pérez
Meera
M
Mahalingam
D047108:Embryonic Development / Q000502:physiology; D005109:Extracellular Matrix / Q000201:enzymology / Q000502:physiology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000502:physiology*; D012867:Skin / Q000196:embryology / Q000503:physiopathology; D012871:Skin Diseases / Q000503:physiopathology*; D012878:Skin Neoplasms / Q000503:physiopathology*; D012879:Skin Physiological Phenomena
D020782:Matrix Metalloproteinases