In vivo evaluation of novel amine-terminated nanopore Ti surfaces.
The aim of this study was to evaluate the effects of the novel nanopore Ti surface and amine-terminated Ti surface on peri-implant bone formation and bone-implant bonding strength in a rabbit tibiae model. Characterization of the modified Ti surface, such as root-mean square roughness, contact angle, and surface energy was evaluated using scanning electron microscopy, atomic force microscopy, and a Contact Angle Measurement System, respectively. The results from alkali treatment indicated that an interpenetrating dimensional porosity surface had been formed, whose morphology was similar to the amine-terminated surface of self-assembled monolayers after alkali treatment. The micro-CT demonstrated that the amine-terminated surface had higher bone volume ratio and higher mean trabecular thickness after 4 weeks of implantation. The push-out test and histological examination showed no significant differences in the maximal force and bone-implant contact between the terminated surface and alkali-treated surface. These novel dimensional nanoporous structures can significantly improve the initial stabilization and the osseointegration.
Guanghua School and Hospital of Stomatology and Institute of Stomatological Research, Sun Yat-sen University, Guangzhou, China.
Xiaolin
X
Yu
Chengyun
C
Ning
Jingping
J
Li
Shanshan
S
Huang
Yuanjun
Y
Guo
Feilong
F
Deng
D000588:Amines / Q000737:chemistry*; D000818:Animals; D001696:Biomechanical Phenomena; D020007:Implants, Experimental; D008297:Male; D018625:Microscopy, Atomic Force; D058608:Nanopores / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D011437:Propylamines; D011817:Rabbits; D012821:Silanes / Q000737:chemistry; D013816:Thermodynamics; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D014025:Titanium / Q000737:chemistry*; D055114:X-Ray Microtomography
D000588:Amines; D011437:Propylamines; D012821:Silanes; D014025:Titanium; C477625:amino-propyl-triethoxysilane