[Polymers as excipients used in the technology of coated tablets containing ibandronic acid derivatives (bisphosphonates)].
Bisphosphonates are used in the treatment of osteoporosis, predominantly most often postmenopausal and glucocorticoid-induced forms. The most commonly known bisphosphonates are: derivatives of alendronic, clodronic, ibandronic, risedronic acid. Bisphosphonates have low bioavailability (1-10%) and low absorption (for more recent bisphosphonates it does not exceed 1%) after oral application (class III of BCS). The discussed group of derivatives is also a technological challenge, particularly in a situation of so difficult biopharmaceutical conditions. The above encourages compliance with the discipline of taking solid oral pharmaceutical forms (tablets), which have to be taken strictly on an empty stomach (30-60 minutes before a meal) and washed down with a glass of boiled water. The technology of oral drug forms with bisphosphonates has to minimize practically to zero the problems of potential adsorption of an active substance on excipients of a character of macromolecular polymers being part of a tablet core and a coating, at the same time providing full pharmaceutical availability.
Zakład Technologii Postaci Leku, Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi. michal.kolodziejczyk@umed.lodz.pl
Michał Krzysztof
MK
Kołodziejczyk
Marian Mikołaj
MM
Zgoda
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004164:Diphosphonates / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005079:Excipients / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry*
D004164:Diphosphonates; D005079:Excipients; D011108:Polymers; D013607:Tablets