Classifying the topology of AHL-driven quorum sensing circuits in proteobacterial genomes.
Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.
Faculty of Information Technology, PázmányPéter Catholic University, Práter u. 50/a, Budapest 1083, Hungary. gelzsolt@gmail.com
Zsolt
Z
Gelencsér
Kumari Sonal
KS
Choudhary
Bruna Goncalves
BG
Coutinho
Sanjarbek
S
Hudaiberdiev
Borisz
B
Galbáts
Vittorio
V
Venturi
Sándor
S
Pongor
D016680:Genome, Bacterial; D010802:Phylogeny; D020560:Proteobacteria / Q000145:classification / Q000235:genetics* / Q000502:physiology; D053038:Quorum Sensing