Co-detection in the pathogenesis of severe hand-foot-mouth disease.
It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
Institute of Health Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100123, People's Republic of China. lljyhxx@126.com
Li-Juan
LJ
Liu
Hong-Mei
HM
Xu
Xiu-Jun
XJ
Li
Jun
J
Wang
Xian-Jun
XJ
Wang
Shu-Jun
SJ
Ding
Fang
F
Tang
Jing
J
Wang
Ying-Jie
YJ
Zhang
D052660:Bocavirus / Q000302:isolation & purification; D002675:Child, Preschool; D060085:Coinfection / Q000473:pathology* / Q000821:virology*; D029821:Enterovirus A, Human / Q000302:isolation & purification*; D005243:Feces / Q000821:virology*; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D029322:Norovirus / Q000302:isolation & purification; D012401:Rotavirus / Q000302:isolation & purification