Association of common PAX9 variants with permanent tooth size variation in non-syndromic East Asian populations.
Studies on the heredity of dental characteristics in humans have indicated that the variance in many dental traits results from genetic variation. However, the genetic factors that influence commonly occurring dental variants are poorly understood. Paired domain box 9 (PAX9) codes a transcription factor that is important in tooth development. We investigated whether PAX9 polymorphisms are associated with normal variations in tooth agenesis and morphology. The study subjects were 273 Japanese and 223 Korean adults. Single-nucleotide polymorphisms (SNPs) in PAX9 (rs2295222, rs4904155, rs2073244, rs12881240 and rs4904210) were genotyped, and third molar agenesis and mesiodistal and buccolingual diameters were measured. We found that four of the five SNPs were significantly associated with the crown size. However, no SNP was associated with third molar agenesis. In additional analyses on non-metric dental traits, we found significant associations of PAX9 SNPs with shoveling of upper first incisors. In summary, common variants in PAX9 contributed to morphological variation in permanent teeth in humans.
Department of Orthodontics, Pusan National University Dental Hospital, Kyeongsangnamdo, Korea.
Won-Chul
WC
Lee
Tetsutaro
T
Yamaguchi
Chiaki
C
Watanabe
Akira
A
Kawaguchi
Mayako
M
Takeda
Yong-Il
YI
Kim
Shugo
S
Haga
Yoko
Y
Tomoyasu
Hajime
H
Ishida
Koutaro
K
Maki
Soo-Byung
SB
Park
Ryosuke
R
Kimura
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000848:Anodontia / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D051764:PAX9 Transcription Factor / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D014070:Tooth / Q000033:anatomy & histology*; D055815:Young Adult
D051764:PAX9 Transcription Factor; C497323:PAX9 protein, human