Analysis of serum activities of matrix metalloproteinases and α1-proteinase inhibitor in patients with type 2 diabetes mellitus.
Activities of matrix metalloproteinases 2 and 7 and α1-proteinase inhibitor were measured in patients with type 2 diabetes mellitus. Correlations between enzyme activity and the main parameters of carbohydrate metabolism were studied. In patients, significant reduction of matrix metalloproteinase activity in the serum was noted, which correlated with the decrease in blood concentration of C-peptide (r=0.8). At the same time, serum activity of α1-proteinase inhibitor increased. No significant relationships between patient's age, glucose concentration, fructosamine concentration, and matrix metalloproteinase activity were observed.
Novosibirsk State Medical University; Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia. olga_Poteryaeva@mail.ru
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Poteryaeva
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Russkich
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Panin
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D019270:Fructosamine / Q000097:blood; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020783:Matrix Metalloproteinase 7 / Q000097:blood*; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000097:blood*
D001786:Blood Glucose; D002096:C-Peptide; D000515:alpha 1-Antitrypsin; D019270:Fructosamine; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2