Stereoselective total synthesis of atpenins a4 and b, harzianopyridone, and NBRI23477 B.
The stereoselective total synthesis of atpenins A4 (2) and B (3), harzianopyridone (4), and NBRI23477 B (5) have been developed using a convergent approach involving the coupling reaction of a common iodopyridine with an aldehyde corresponding to the appropriate side chain of the desired compound. Furthermore, the absolute configurations of atpenin B (3), harzianopyridone (4), and NBRI23477 B (5) have been unambiguously determined.
Graduate School of Pharmaceutical Sciences, Kitasato University, 5–9–1 Shirokane, Minato-ku, Tokyo, Japan.
Masaki
M
Ohtawa
Kouhei
K
Sugiyama
Tohru
T
Hiura
Shujiro
S
Izawa
Kazuro
K
Shiomi
Satoshi
S
Omura
Tohru
T
Nagamitsu
D000447:Aldehydes / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; C576303:NBRI23477 B; D011725:Pyridines; D011728:Pyridones; C576302:harzianopyridone; C058277:atpenin A4; C058279:atpenin B; C023666:pyridine