[Simultaneous determination of three coumarins in Angelica dahurica var. formosana by QAMS].
OBJECTIVE
To develop a quantitative analysis of multi-components by single marker(QAMS) method for simultaneous determination of three coumarins in Angelica dahurica var. formosana, by using one standard substance.


METHODS
With imperatorin as internal reference standard, and 2 relative correction factors (RCF) to imperatorin were calculated within certain ranges. Their contents in 20 batches of samples, collected from different areas, were determined by both external standard method and QAMS. The method was evaluated by comparison of the quantitative results between the two methods.


RESULTS
No significant differences were found in the quantitative results of three coumarins in 20 batches of A. dahurica var. formosana determined by the two methods (RSD < 5%).


CONCLUSIONS
QAMS is feasible and suitable for quality control of A. dahurica var. formosana.
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. yff8201@sohu.com
Fang
F
Yang
Li
L
Wan
Yichen
Y
Hu
Wei
W
Lv
Yi
Y
Zhang
D029969:Angelica / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D011564:Furocoumarins / Q000737:chemistry; D012015:Reference Standards
D003374:Coumarins; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; C031534:imperatorin