Ocimum Sanctum seeds, a natural superdisintegrant: formulation and evaluation of fast melt tablets of nimesulide.
BACKGROUND
Fast melt tablets, also known as fast dissolving tablets, disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate fast melt tablets of nimesulide by using Ocimum Sanctum seeds as a natural tablet superdisintegrant.


METHODS
Powdered Ocimum seeds were characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, loss on drying and microbial load. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in vitro and in vivo disintegration time, in-vitro dissolution and stability studies.


RESULTS
The swelling index was evaluated to be 1600. An appreciable effect of the natural material was seen on tablet hardness and friability. The water absorption ratio increased from 56.15 +/- 0.85 to 80.76 +/- 0.70 (A1-A4). Water uptake coupled natural polymer swelling could be the most probable mechanism for concentration dependent reduction in disintegration time by the Ocimum Sanctum seeds. Porosity of the formulated tablets was found to increase from batch A1-A4. The in vitro disintegration results were in line with in vivo disintegration results. The f2 values (in comparison with Nimulid MD) of 95.90 and 93.65 were obtained with A3 and A4 batches respectively.


CONCLUSIONS
It could be concluded that Ocimum Sanctum seeds could be used as a natural superdisintegrant in the formulation of fast melt tablets.
School of Pharmaceutical Sciences, Chitkara University, Solan-174103, Himachal Pradesh, India. karan2364@gmail.com
Karan
K
Malik
Gurpreet
G
Arora
Inderbir
I
Singh
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D016062:Porosity; D011208:Powders / Q000737:chemistry; D012639:Seeds / Q000737:chemistry* / Q000382:microbiology; D012995:Solubility; D013449:Sulfonamides / Q000008:administration & dosage / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength; D014783:Viscosity; D014867:Water / Q000737:chemistry
D011208:Powders; D013449:Sulfonamides; D013607:Tablets; D014867:Water; C012655:nimesulide