Multilocus variable-number tandem-repeat analysis-confirmed emergence of a macrolide resistance-associated mutation in Mycoplasma pneumoniae during macrolide therapy for interstitial pneumonia in an immunocompromised child.
A child with Job's syndrome was treated for pneumonia due to Mycoplasma pneumoniae. A mixed population of wild-type bacteria and an A2059G mutant was detected during josamycin treatment failure. The same multilocus variable-number tandem-repeat analysis (MLVA) type (MLVA type I) was isolated before and after treatment failure. The child recovered after ciprofloxacin treatment.
Université de Limoges, Limoges, France.
Sébastien
S
Hantz
Fabien
F
Garnier
Olivia
O
Peuchant
Céline
C
Menetrey
Alain
A
Charron
Marie-Cécile
MC
Ploy
Cécile
C
Bébéar
Sabine
S
Pereyre
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002939:Ciprofloxacin / Q000008:administration & dosage; D024881:Drug Resistance, Bacterial; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy* / Q000382:microbiology; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018598:Minisatellite Repeats; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy* / Q000382:microbiology; D016879:Salvage Therapy / Q000379:methods; D017211:Treatment Failure
D000900:Anti-Bacterial Agents; D018942:Macrolides; D002939:Ciprofloxacin