Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis.
BACKGROUND
Epidemiological studies investigating the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis.


METHODS
PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models.


RESULTS
Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00-2.19 for D vs. I; OR = 1.61, 95% CI, 1.14-2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04-1.97 for DD and DI vs. II), but not in Asians.


CONCLUSIONS
Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings.
Department of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, China.
Hongxia
H
Jia
Bin
B
Wang
Lili
L
Yu
Zhaoshun
Z
Jiang
D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A