[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].
OBJECTIVE
To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.


METHODS
Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg(-1)) group, the TMP+TET (30 mg x kg(-1) mg x kg(-1)) group and the TMP+FA+TET (30 mg x kg(-1) + 50 mg x kg(-1) + 20 mg x kg(-1)) group. After the oral administration, their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.


RESULTS
In compatibility with FA, AUC(0-t), Cmax and Tmax showed no significant difference with the single administration of TMP, but t(1/2) and MRT,, were obviously longer than the single administration. In compatibility with TET and FA + TET, AUC (0-t), Cmax and Tmax showed significant increase than the single administration of TMP, whereas t(1/2) and MRT0, did not notably vary from the single administration.


CONCLUSIONS
FA can prolong TMP's action time in rats, and TET can accelerate TMP's absorption in rats.
Chongqing Three Gorges Medical College, Chongqing 404120, China. fbb200596@126.com
Binbin
B
Feng
Jianhai
J
Zhang
Jifen
J
Zhang
Gang
G
Chen
Xiaoyu
X
Xu
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000493:pharmacokinetics; D004224:Diterpenes / Q000493:pharmacokinetics; D004347:Drug Interactions; D005260:Female; D011719:Pyrazines / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D003373:Coumaric Acids; D004224:Diterpenes; D011719:Pyrazines; C004999:ferulic acid; C014224:tiamulin; C017953:tetramethylpyrazine