Long-term effects of prenatal stress on the characteristics of hippocampal neurons in rats with different excitability of the nervous systems.
We studied the effects of prenatal emotional painful stress on numerical density of neurons and characteristics of heterochromatin in developing and mature hippocampus of rats with different excitability of the nervous systems. It was shown that prenatal stress reduces the numerical density of neurons in hippocampal CA3 field in 24-day-old and adult (3 months) low excitable animals and chromocenter area in cells of developing hippocampus in embryos of both strains. The difference in chromocenter areas in offspring of stressed females was retained on postnatal day 24.
Laboratory of Higher Nervous Activity Genetics, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. dyuzhikova@mail.ru
N A
NA
Dyuzhikova
N V
NV
Shiryaeva
M B
MB
Pavlova
A I
AI
Vaido
D000367:Age Factors; D000818:Animals; D056654:CA3 Region, Hippocampal / Q000166:cytology* / Q000502:physiology; D002452:Cell Count; D004622:Embryo, Mammalian; D005260:Female; D006570:Heterochromatin / Q000737:chemistry*; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D010146:Pain / Q000523:psychology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology; D051381:Rats; D011930:Reaction Time; D013045:Species Specificity; D013315:Stress, Psychological / Q000503:physiopathology; D013995:Time
D006570:Heterochromatin