Challenges for nanomechanical sensors in biological detection.
Nanomechanical biosensing relies on changes in the movement and deformation of micro- and nanoscale objects when they interact with biomolecules and other biological targets. This field of research has provided ever-increasing records in the sensitivity of label-free detection but it has not yet been established as a practical alternative for biological detection. We analyze here the latest advancements in the field, along with the challenges remaining for nanomechanical biosensors to become a commonly used tool in biology and biochemistry laboratories.
Institute of Microelectronics of Madrid, CSIC, Isaac Newton 8 (PTM), Tres Cantos, 28760 Madrid, Spain. mcalleja@imm.cnm.csic.es
Montserrat
M
Calleja
Priscila M
PM
Kosaka
Álvaro
Á
San Paulo
Javier
J
Tamayo
D001419:Bacteria / Q000302:isolation & purification; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D007368:Interferometry; D008027:Light; D008904:Miniaturization; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D014780:Viruses / Q000302:isolation & purification
D009841:Oligonucleotides; D011506:Proteins