Maternal and fetal plasma platelet-activating factor acetylhydrolase activity and distribution in pre-eclampsia.
BACKGROUND
Distribution of platelet-activating factor acetylhydrolase (PAF-AH) in lipoproteins plays important roles in the onset of inflammation and atherosclerosis. We hypothesized that women with pre-eclampsia (PE), showing signs of inflammation and oxidative stress, and their fetuses have aberrations of PAF-AH activity and distribution.


METHODS
Maternal and fetal plasma PAF-AH activity, high-density lipoprotein (HDL)-associated PAF-AH (H-PAF-AH) and low-density lipoprotein (LDL)-associated PAF-AH (L-PAF-AH) were examined in women with PE (n = 127) and in women with uncomplicated pregnancies (n = 88).


RESULTS
The neonates of women with severe PE (n = 42) had significantly higher plasma PAF-AH, L-PAF-AH activities, and ratio of L-PAF-AH to H-PAF-AH activities than the neonates of women with normal pregnancies (n = 83). The mothers with severe PE (n = 106) and their neonates presented a significantly higher atherogenic index (AI) and triglyceride (TG)/HDL cholesterol (C) ratio than the control mothers and their neonates. The ratio of L-PAF-AH to H-PAF-AH activities correlated positively with TG levels, TG/HDL(C) ratio, and AI and negatively with HDL(C) levels in the neonates of women with PE.


CONCLUSIONS
The neonates of women with severe PE presented with a chronic inflammation status, increased oxidative stress, and unfavorable lipid changes, which may potentially link to related complications responsible for oxidative stress and inflammation in later life.
Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Sichuan, People's Republic of China.
Ping
P
Fan
Xing-Hui
XH
Liu
Guo-Lin
GL
He
Shuo
S
Zhang
Jin-Xia
JX
Zhang
Huai
H
Bai
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006801:Humans; D007231:Infant, Newborn; D054467:Phospholipases A2 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D011247:Pregnancy; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation; D055815:Young Adult
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C526684:PLA2G7 protein, human