Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro.
The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.
Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
Eric
E
Chau
Justin F
JF
Galloway
Antoinette
A
Nelson
Patrick N
PN
Breysse
Denis
D
Wirtz
Peter C
PC
Searson
Venkataramana K
VK
Sidhaye
D001692:Biological Transport; D001980:Bronchi / Q000166:cytology*; D019187:Cadmium Compounds / Q000737:chemistry; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D045663:Quantum Dots / Q000737:chemistry* / Q000378:metabolism*; D018036:Selenium Compounds / Q000737:chemistry; D013499:Surface Properties
D019187:Cadmium Compounds; D018036:Selenium Compounds; C058667:cadmium selenide