Compensatory function of submandibular gland in mice with streptozotocin diabetes under conditions of transplantation.
Transplantation of the submandibular gland under the renal capsule of mice with streptozotocin-induced diabetes mellitus stimulated the compensatory function of the recipient submandibular gland. An increase in insulin I and insulin II gene expression in the submandibular gland after transplantation was demonstrated by PCR. More intensive production and extrusion of these proteins in the apical and basal directions in granular compartment cells of the submandibular gland was confirmed by electron microscopy. All these changes led to a reduction of blood glucose levels in diabetic animals as soon as 2-2.5 weeks after transplantation.
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. inessagvazava@hotmail.ru
I G
IG
Gvazava
A V
AV
Vasiliev
O V
OV
Balan
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000601:surgery / Q000628:therapy*; D005260:Female; D015870:Gene Expression; D007328:Insulin / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D000078790:Insulin Secretion; D007668:Kidney / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D016133:Polymerase Chain Reaction; D013363:Submandibular Gland / Q000378:metabolism / Q000637:transplantation*; D016042:Transplantation, Heterotopic; D014184:Transplantation, Homologous
D001786:Blood Glucose; C514817:Ins1 protein, mouse; C561967:Ins2 protein, mouse; D007328:Insulin