The role of complement regulatory proteins in peripheral blood cells of patients with systemic lupus erythematosus: review.
CD55, CD59, CD35 and CD46 are cell membrane proteins that have regulatory properties on the activation of the complement cascade. Deficiency in the expression of these proteins may be associated with lower protection of healthy cells against complement mediated lysis and also with the accumulation of immune complexes in tissues. Few studies assess the expression of these proteins in patients with SLE and the mechanisms that regulate reduction in cellular expression, whereas its impact on manifestations of systemic lupus erythematosus is still unknown.
Serviço de Patologia Clínica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil. anaalegretti@gmail.com
Ana Paula
AP
Alegretti
Laiana
L
Schneider
Amanda Kirchner
AK
Piccoli
Ricardo Machado
RM
Xavier
D000936:Antigen-Antibody Complex / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D001773:Blood Cells / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male
D000936:Antigen-Antibody Complex; D015703:Antigens, CD; D003165:Complement System Proteins