Autologous formalin-fixed tumor vaccine suppressed re-recurrence of HCV-related hepatocellular carcinoma following 29 unsuccessful treatments with extensive conventional therapy: a case report.
Treatment of hepatocellular carcinoma (HCC) with autologous formalin-fixed tumor vaccine after primary resection has been shown to suppress the recurrence of hepatitis B virus-associated HCC, but the effect of this treatment on hepatitis C virus (HCV)-related disease has not yet been clarified. Here, we report a case of a patient with repeat recurrent HCC that was associated with HCV who had endured 29 episodes of HCC recurrence despite a variety of therapy using conventional methods. Finally, treatment with a single course of autologous formalin-fixed tumor vaccine resulted in suppression of potential further re-recurrence of HCC for more than 43 months without any additional treatment.
Inui Cancer Immunotherapy Clinic, 6-14-17 Kinndachou, Moriguchi-shi, Osaka 570-0011, Japan. inui-cl@nike.eonet.ne.jp
Toshio
T
Inui
Tadao
T
Ohno
D000328:Adult; D019496:Cancer Vaccines / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy* / Q000821:virology; D005404:Fixatives / Q000737:chemistry; D005557:Formaldehyde / Q000737:chemistry*; D016174:Hepacivirus / Q000472:pathogenicity*; D006498:Hepatectomy / Q000009:adverse effects; D006526:Hepatitis C / Q000473:pathology / Q000628:therapy* / Q000821:virology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy* / Q000821:virology; D011379:Prognosis; D055815:Young Adult
D019496:Cancer Vaccines; D005404:Fixatives; D005557:Formaldehyde