[Alterations in lipidic metabolism in hemodialysis patients].
BACKGROUND
Chronic kidney failure is associated with dyslipidemia and accelerated atherosclerosis.


OBJECTIVE
To study lipidic metabolism alterations in patients with chronic kidney failure on hemodialysis.


METHODS
The study interested 45 hemodialysis patients with a mean age of 49.04 ±15.92 years old and 45 healthy controls. A blood sample was collected from each patient and control to measure total cholesterol, triglycerides, HDL- cholesterol, LDL-cholesterol, apolipoproteins AI and B100, lipoprotein (a) and C Reactive Protein.


RESULTS
A significant increase of serum triglycerides (p= 0.002), lipoprotein (a) (p = 0.001) and C Reactive Protein (p = 0.008) was observed in patients when compared with healthy controls. A significant decrease of serum total cholesterol (p=0.01), HDLcholesterol (p<0.001), LDL-cholesterol (p=0.005) and apolipoprotein AI (p<0.001) was also observed in patients.


CONCLUSIONS
Disorders of lipidic metabolism are frequent in hemodialysis patients. These alterations can lead to cardiovascular disease in uremic patients.
Faculte de Medecine de Tunis, Universite Tunis, El Manar, Tunisie.
Ines
I
Kharrat
Aouatef
A
Jmal
Lobna
L
Jmal
Zeineb
Z
Amira
Walid
W
Ben Cheikh
Ferid
F
Ben Bourouba
Lotfi
L
Sahnoun
Monia
M
Abdennebi
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D055815:Young Adult