Management of tibial non-union with tricalcium phosphate and BMP 7.
We present the case of a 30-year-old woman who was referred with an established tibial non-union with a bone defect following a spiral fracture of the tibia. Initial attempts at union with intramedullary fixation and then autograft were unsuccessful. We achieved union by debriding the fibrous tissue and packing the defect with Bone Morphogenetic Protein 7 (Osigraft, Stryker, UK) and a tricalcium phosphate bone void filler (Calstrux, Stryker, UK). We did not use any additional surgical fixation and the patient was supported in an aircast boot.
Department of Plastic Surgery, Stoke Mandeville Hospital, Aylesbury, UK. jonathan.cubitt@hotmail.co.uk
Jonathan
J
Cubitt
Andrew
A
McAndrew
D000328:Adult; D055419:Bone Morphogenetic Protein 7 / Q000008:administration & dosage / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D055419:Bone Morphogenetic Protein 7; D002130:Calcium Phosphates; C018392:tricalcium phosphate