Comparison of urine dipstick, sulfosalicylic acid, urine protein-to-creatinine ratio and a feline-specific immunoassay for detection of albuminuria in cats with chronic kidney disease.
The performance of the urine dipstick, sulfosalicylic acid (SSA), and urine protein-to-creatinine (UPC) tests for the detection of albuminuria was assessed in cats with chronic kidney disease (CKD). Two hundred and thirty-nine urine samples from 37 cats with CKD were used. Test results were dichotomized as either positive or negative, compared with those for the feline-specific rapid urine albumin immunoassay and test performance variables calculated for each test. A positive urine dipstick (≥ trace) and positive SSA (≥ 5 mg/dl), positive SSA alone or ≥ 2+ urine dipstick alone were indicative of albuminuria. In these cases, protein quantification would be warranted if proteinuria/albuminuria is persistent. In the case of a negative urine dipstick result the addition of the SSA added little diagnostic value. Of the tests investigated, the single best test for the detection of albuminuria was the UP/C (≥ 0.2) in which either a negative or positive test result provided useful information.
Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA. andrew.hanzlicek@okstate.edu
Andrew S
AS
Hanzlicek
Clinton J
CJ
Roof
Michael W
MW
Sanderson
Gregory F
GF
Grauer
D000419:Albuminuria / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D001557:Benzenesulfonates / Q000737:chemistry*; D002371:Cat Diseases / Q000175:diagnosis / Q000652:urine*; D002415:Cats / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary*; D005260:Female; D008297:Male; D011934:Reagent Strips; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000662:veterinary*; D012459:Salicylates / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013045:Species Specificity
D001557:Benzenesulfonates; D011934:Reagent Strips; D012459:Salicylates; C003366:sulfosalicylic acid