Bioinformatics analysis reveals connection of squamous cell carcinoma and adenocarcinoma of the lung.
Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.
Department of Oncology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei-Dong
WD
Fan
Xian-Quan
XQ
Zhang
Hui-Lin
HL
Guo
Wei-Wei
WW
Zeng
Ni
N
Zhang
Qian-Qian
QQ
Wan
Wen-Yao
WY
Xie
Jin
J
Cao
Chang-Hua
CH
Xu
D000230:Adenocarcinoma / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D005796:Genes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D014157:Transcription Factors
D014157:Transcription Factors