Regulation of hemodynamic parameters under conditions of systemic administration of angiotensin II and angiotensin IV to rats after carotid glomectomy.
Systemic administration of angiotensin II was followed by an increase in systolic BP and HR in rats with carotid glomectomy, the time of attaining maximum values in treated animals was much higher than in sham-operated controls. Injection of angiotensin IV slightly reduced systolic BP in sham-operated animals and increased it in rats with carotid glomectomy. The involvement of the local renin-angiotensin system of the carotid body in systemic mechanisms of hemodynamics regulation is discussed.
Laboratory for Physiology of Motivations, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences.
E I
EI
Pevtsova
O N
ON
Serova
L V
LV
Shevchenko
A I
AI
Elfimov
A V
AV
Kotov
V I
VI
Torshin
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002344:Carotid Body / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology
D000804:Angiotensin II; C012877:angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-