Experimental infection of laboratory-bred bank voles (Myodes glareolus) with murid herpesvirus 4.
MuHV-4 is a natural pathogen of rodents of the genus Apodemus (e.g., wood mice, yellow-necked mice) and Myodes glareolus (bank voles). We report experimental MuHV-4 infection of bank voles in comparison with infection of A. sylvaticus (wood mice) and BALB/c mice. Like in wood mice, the level of productive replication in the lungs of bank voles was significantly lower than in BALB/c mice. In contrast to other hosts, however, the level of latent infection in the lung and spleen of bank voles was extremely low. These findings, together with those of previous studies, suggest that bank voles are an occasional and inefficient host for MuHV-4.
Department of Infection Biology, University of Liverpool, Liverpool L69 7ZJ, UK.
David J
DJ
Hughes
Anja
A
Kipar
Gail
G
Leeming
Jeffery T
JT
Sample
James P
JP
Stewart
D000825:Animal Structures / Q000473:pathology / Q000821:virology; D000818:Animals; D003411:Arvicolinae / Q000821:virology*; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008962:Models, Theoretical; D051189:Murinae / Q000821:virology*; D018144:Rhadinovirus / Q000302:isolation & purification / Q000472:pathogenicity*; D012376:Rodent Diseases / Q000473:pathology* / Q000821:virology; D014412:Tumor Virus Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology