A feud that wasn't: acetylcholine evokes dopamine release in the striatum.
In this issue of Neuron, Threlfell et al. (2012) report that synchronous activation of cholinergic interneurons evokes striatal dopamine release by activating presynaptic nicotinic acetylcholine receptors. These findings call for a fundamental reevaluation of the long-standing view that dopamine and acetylcholine "feud" over control of striatal circuitry.
Department of Physiology, Feinberg College of Medicine, Northwestern University, Chicago, IL 60611, USA. j-surmeier@northwestern.edu
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