Charge transport within a three-dimensional DNA nanostructure framework.
Three-dimensional (3D) DNA nanostructures have shown great promise for various applications including molecular sensing and therapeutics. Here we report kinetic studies of DNA-mediated charge transport (CT) within a 3D DNA nanostructure framework. A tetrahedral DNA nanostructure was used to investigate the through-duplex and through-space CT of small redox molecules (methylene blue (MB) and ferrocene (Fc)) that were bound to specific positions above the surface of the gold electrode. CT rate measurements provide unambiguous evidence that the intercalative MB probe undergoes efficient mediated CT over longer distances along the duplex, whereas the nonintercalative Fc probe tunnels electrons through the space. This study sheds new light on DNA-based molecular electronics and on designing high-performance biosensor devices.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Na
N
Lu
Hao
H
Pei
Zhilei
Z
Ge
Chad R
CR
Simmons
Hao
H
Yan
Chunhai
C
Fan
D001483:Base Sequence; D001692:Biological Transport; D004247:DNA / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry; D000075163:Metallocenes; D008751:Methylene Blue / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*
D005296:Ferrous Compounds; D000075163:Metallocenes; D004247:DNA; D008751:Methylene Blue; C004998:ferrocene