High sensitivity of gastric mucosa to ulcerogenic effect of indomethacin in rats with diabetes.
One week after injection of streptozotocin (60 mg/kg intravenously), rats developed diabetes associated with a significant increase of gastric mucosa sensitivity to the ulcerogenic effect of indomethacin (35 mg/kg subcutaneously). Since potentiation of the ulcerogenic effect of indomethacin was observed only in rats subjected to fasting before drug injection, we hypothesize that this effect was caused by a drop of high glucose level in the blood after fasting.
Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia. tpodvigina@yandex.ru
T T
TT
Podvigina
T R
TR
Bagaeva
P Yu
PY
Bobryshev
L P
LP
Filaretova
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D001786:Blood Glucose; D003345:Corticosterone / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000503:physiopathology; D004327:Drinking Behavior; D005215:Fasting; D005753:Gastric Mucosa / Q000473:pathology / Q000503:physiopathology*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000209:etiology; D013311:Streptozocin
D001786:Blood Glucose; D013311:Streptozocin; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D007213:Indomethacin