Negative regulators take center stage.
The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset.
Institute for Research in Biomedicine, Bellinzona, Switzerland. silvia.monticelli@irb.usi.ch
Silvia
S
Monticelli
Federica
F
Sallusto
D000818:Animals; D051740:Ikaros Transcription Factor; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D058504:Th17 Cells / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*
C491396:Ikzf3 protein, mouse; D007376:Interleukin-2; D015534:Trans-Activators; D051740:Ikaros Transcription Factor