Evaluation of lidocaine treatment on frequency of cardiac arrhythmias, acute kidney injury, and hospitalization time in dogs with gastric dilatation volvulus.
OBJECTIVE
To assess the efficacy of IV lidocaine in decreasing complication rate and improving the outcome in dogs with gastric dilatation volvulus (GDV).


METHODS
Prospective non-controlled study of 83 lidocaine-treated dogs with GDV compared to 47 untreated historical controls with GDV.


METHODS
University veterinary teaching hospital.


METHODS
One hundred and thirty client-owned dogs with naturally occurring GDV.


METHODS
Study group dogs were treated at presentation with lidocaine (2 mg/kg, IV bolus) followed by constant rate infusion (CRI) of 0.05 mg/kg/min for 24 h. Historical control dogs did not receive any lidocaine.


RESULTS
There were no group differences in age, body weight, time lag from onset of clinical signs to presentation, rectal temperature and pulse rate at presentation, and proportion of gastric wall necrosis. The proportions of cardiac arrhythmias and acute kidney injury (AKI) were significantly (P< 0.001 and P = 0.045, respectively) lower in the lidocaine group (10/83 [12%] versus 18/47 [38.3%] and 3/83 [3.6] versus 0/47). Median hospitalization time period was shorter (P = 0.05) in the lidocaine group compared to the controls (median 48 h; range 24-360 h versus median 72 h; range 24-144 h, respectively).


CONCLUSIONS
Early treatment with IV lidocaine bolus, followed by CRI of lidocaine for 24 h post presentation decreased the occurrence of cardiac arrhythmias, AKI and hospitalization time period significantly in lidocaine-treated dogs with GDV compared to untreated historical controls. Due to the nonblinded, placebo-uncontrolled, nonrandomized nature of the current study, further evaluation of the efficacy of lidocaine in dogs with GDV is warranted.
Koret School of Veterinary Medicine, Veterinary Teaching Hospital, The Hebrew University of Jerusalem, Rehovot, 76100, Israel. bruchim@agri.huji.ac.il
Yaron
Y
Bruchim
Srugo
S
Itay
Ben-Halevy
BH
Shira
Efrat
E
Kelmer
Yudelecitch
Y
Sigal
Aroch
A
Itamar
Segev
S
Gilad
D058186:Acute Kidney Injury / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D013271:Gastric Dilatation / Q000662:veterinary*; D006760:Hospitalization; D008012:Lidocaine / Q000627:therapeutic use*; D013277:Stomach Volvulus / Q000662:veterinary*; D013997:Time Factors
D008012:Lidocaine