Direct fluorination of phenolsulfonphthalein: a method for synthesis of positron-emitting indicators for in vivo pH measurement.
We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting (18)F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 195 John Morgan Building, Philadelphia, PA 19104-6072, USA. kachur@mail.med.upenn.edu
Alexander V
AV
Kachur
Anatoliy V
AV
Popov
Joel S
JS
Karp
E James
EJ
Delikatny
D019342:Acetic Acid / Q000737:chemistry; D004583:Electrons; D005461:Fluorine / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010637:Phenolsulfonphthalein / Q000737:chemistry*
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D005461:Fluorine; D010637:Phenolsulfonphthalein; D019342:Acetic Acid