Microwave-assisted deacylation of unactivated amides using ammonium-salt-accelerated transamidation.
The combination of an ammonium salt and ethylenediamine promotes deacylation of a variety of unactivated amides to give the corresponding amines in high yields without the use of strong acids or bases. The reactions proceed without special care regarding air and moisture, and tolerate a wide range of functional groups.
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan.
Yuhei
Y
Shimizu
Hiroyuki
H
Morimoto
Ming
M
Zhang
Takashi
T
Ohshima
D000215:Acylation; D000577:Amides / Q000737:chemistry*; D000579:Amidinotransferases / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis*; D008872:Microwaves; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*
D000577:Amides; D000588:Amines; D000644:Quaternary Ammonium Compounds; D000579:Amidinotransferases