Evaluation of WO2012078210--development process for the preparation of a DP2 receptor antagonist; Ironwood's first development DP2 antagonist.
This application claims processes for the preparation of a series of pyrrole-based DP2 receptor antagonists, in particular 2-[3-cyano-2,5-dimethyl-4-[(2-pyrrolidin-1-ylsulfonylphenyl)methyl]pyrrol-1-yl]acetic acid. The nature of the filing points to this compound being a development compound and it may be IW-1221 which has previously been identified as a DP2 antagonist.
Norman Consulting, 18 Pink Lane, Burnham, Bucks, SL1 8JW, UK. peter.norman2@btinternet.com
Peter
P
Norman
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D015394:Molecular Structure; D010330:Patents as Topic; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*
D018927:Anti-Asthmatic Agents; D011758:Pyrroles; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor