Meta-analysis of epidemiological  studies  demonstrates significant association of PTGS2  polymorphism rs689470 and no significant association of rs20417 with prostate cancer.
Evidence  is accumulating that chronic inflammation has an important role in prostate  cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2  (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for  prostate cancer, but the various studies are not in agreement. To derive a more  precise estimation of this association, all available studies were considered  in a meta-analysis, with 10,700 patients and 13,021 controls for rs20417 and  4087 patients and 3761 controls for rs689470. We used odds ratios (ORs) to  assess the strength of the association, and 95% confidence intervals (CIs) to  determine the precision of the estimate. When all groups were pooled, we did  not detect a significant association of rs20417 polymorphism with prostate  cancer risk. Similarly, no associations were found in the subgroup analysis.  However, we found that rs689470 was significantly associated with a trend  towards increased prostate cancer risk when using both additive (OR = 2.15,  95%CI = 1.04-4.44, P = 0.04) and recessive models (OR = 2.07, 95%CI =  1.07-4.03, P = 0.03) to analyze the data. In subgroup analyses stratified by  ethnicity, there was no evidence that rs689470 has a significant association  with prostate cancer in Caucasians. Based on our meta-analysis, rs689470  polymorphism is significantly associated with prostate cancer risk in the  overall population. Nevertheless, we suggest that further studies should be  made to confirm these findings.
Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China.
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D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*
D051546:Cyclooxygenase 2