Physicochemical simulation of cell-cell commutation.
Strings, anisometric structures with length-diameter ratio of 10(1)-10(5) are formed in some homochiral solutions at a concentration of 10(-3)-10(-2) M. We studied macroscopic properties of strings (strength, charge at the ends, etc.) and showed that these strings can provide a power commutation of cells. The strength and electrostatic driving force of the strings are sufficient to transport cells with a velocity of app. 1 cm/sec. The formation of strings is a mechanism of directional and error-resistant information exchange and for intercellular distances it is faster and more efficient by substance utilization than the diffusion mechanism. This suggests that strings or similar objects, including cytonemes, play an important role in various aspects of cell-cell commutation.
N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. s.stovbun@chph.ras.ru
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Stovbun
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Skoblin
D040761:Biomimetic Materials / Q000737:chemistry*; D002450:Cell Communication; D004058:Diffusion; D005782:Gels / Q000737:chemistry*; D007536:Isomerism; D008853:Microscopy; D008954:Models, Biological; D012996:Solutions / Q000737:chemistry*; D055672:Static Electricity
D005782:Gels; D012996:Solutions