Association between neutrophil to lymphocyte ratio and severity of coronary artery disease.
The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups (P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease.
1Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Hasan
H
Kaya
Faruk
F
Ertaş
Yahya
Y
İslamoğlu
Zekeriya
Z
Kaya
Zuhal Arıtürk
ZA
Atılgan
Habib
H
Çil
Ahmet
A
Çalışkan
Mesut
M
Aydın
Mustafa
M
Oylumlu
Mehmet Serdar
MS
Soydinç
D050197:Atherosclerosis / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D012307:Risk Factors; D012720:Severity of Illness Index