A facile and efficient procedure for the synthesis of new benzimidazole-2-thione derivatives.
A series of benzimidazole-2-thione derivatives was synthesized using a reaction between the macrocyclic aminal 16H,13H-5:12,7:14-dimethanedibenzo[d,i]-[1,3,6,8] tetraazecine (DMDBTA, 5) and various nucleophiles in the presence of carbon disulfide. A full chemical characterization using IR, ¹H-, ¹³C-NMR and GC-MS analyses of the new compounds is provided. These compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form in 15%-51.4% yield.
Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Cra.30 No.45-03, Bogotá 111321, Colombia. ariverau@unal.edu.co
Augusto
A
Rivera
Mauricio
M
Maldonado
Jaime
J
Ríos-Motta
D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry
D001562:Benzimidazoles; D013871:Thiones