Salbutamol: beware of the paradox!
A 7-year-old known asthmatic presented with an acute severe asthma attack to the Accident and Emergency department. Following a poor response to salbutamol and ipratropium nebulisers, he was given intravenous salbutamol and aminophylline. Over the course of the following 3 h, there was improvement in his bronchospasm with decreasing oxygen requirement, however, his respiratory rate showed an upward trend. Serial blood gas estimations showed a worsening metabolic acidosis unresponsive to two fluid boluses of 20 ml/kg of normal saline. Lactate levels were subsequently measured and found to be high, accounting for the metabolic acidosis. High lactate levels were attributed to intravenous salbutamol. His blood gases and lactate level returned to normal within 3 h after stopping intravenous salbutamol. He was recommended on salbutamol nebulisers while still continuing on intravenous aminophylline. He continued to improve and was discharged home after 4 days.
Department of Paediatrics, Mayday University Hospital, Croydon, UK. rohitlibran2002@doctors.org.uk
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D000140:Acidosis, Lactic / Q000139:chemically induced*; D000420:Albuterol / Q000009:adverse effects* / Q000627:therapeutic use; D001784:Blood Gas Analysis; D001993:Bronchodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004636:Emergency Service, Hospital; D006801:Humans; D008297:Male; D013224:Status Asthmaticus / Q000188:drug therapy
D001993:Bronchodilator Agents; D000420:Albuterol