Amphoteric calix[8]arene-based complex for pH-triggered drug delivery.
Amphoteric calix[8]arene with negatively charged upper rim and positively charged lower rim was synthesized based on water-soluble p-sulfonato-calix[8]arene. The pH-sensitive amphoteric calix[8]arenes exhibit not only a good hydrophobic drug loading capacity but also a pH-triggered drug releasing behavior. The in vitro release studies demonstrated that release of ciprofloxacin from amphoteric calix[8]arene complexes was highly pH-sensitive. More efficient drug release was observed at mildly acidic pH 5.0 and basic pH 8.5 compared to physiological pH. The amphoteric calix[8]arene complexes hold out great promise of being pH-sensitive drug carrier.
Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick, Canada.
Yan
Y
Xue
Yong
Y
Guan
Anna
A
Zheng
Huining
H
Xiao
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D007202:Indicators and Reagents; D047250:Calixarenes; D002939:Ciprofloxacin