New mutation of mitochondrial DNAJC19 causing dilated and noncompaction cardiomyopathy, anemia, ataxia, and male genital anomalies.
BACKGROUND
We report a new mutation in the human DNAJC19 gene that causes early onset dilated cardiomyopathy syndrome (DCMA).


METHODS
Two brothers of Finnish origin presented with an unusual combination of early onset dilated cardiomyopathy syndrome, a disease which was associated with cardiac noncompaction, microcytic anemia, ataxia, male genital anomalies and methylglutaconic aciduria type V. Suspicion of a DCMA syndrome prompted sequencing of the human DNAJC19 gene.


RESULTS
Sequencing of the human DNAJC19 gene showed a homozygous single nucleotide (A) deletion in alanine 63 coding triplet in exon 6, which does not immediately cause amino acid change but leads 11 amino acids later to a stop codon and to premature termination of the peptide. This DNAJC19 protein is located in the inner mitochondrial membrane and has been shown to function as a mitochondrial chaperone.


CONCLUSIONS
This is the first clinical report of DCMA syndrome, a human DNAJC19 deficiency, that is related to cases of severe dilated cardiomyopathy diagnosed in Europe. DNAJC19 deficiency causes a relatively specific finding in urinary organic acid analysis (methylglutaconic aciduria type V), which together with the clinical features of the ensuing cardiac disease, allows for effective screening before undertaking molecular genetic analysis.
Department of Pediatric Cardiology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. tiina.h.ojala@hus.fi
Tiina
T
Ojala
Padmini
P
Polinati
Tuula
T
Manninen
Anita
A
Hiippala
Jukka
J
Rajantie
Riitta
R
Karikoski
Anu
A
Suomalainen
Tiina
T
Tyni
D000015:Abnormalities, Multiple / Q000235:genetics*; D000595:Amino Acid Sequence; D000740:Anemia / Q000235:genetics* / Q000628:therapy; D001259:Ataxia / Q000235:genetics* / Q000628:therapy; D001344:Autopsy; D001483:Base Sequence; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000628:therapy; D002478:Cells, Cultured; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D017809:Fatal Outcome; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D010641:Phenotype; D013577:Syndrome; D014564:Urogenital Abnormalities / Q000235:genetics* / Q000628:therapy
C511724:DNAJC19 protein, human; D033681:Mitochondrial Membrane Transport Proteins