Pharmacological properties of granulocytic colony-stimulating factor pegylated using electron beam synthesis nanotechnologies.
Granulocytic CSF pegylated using electron-beam synthesis nanotechnology exhibits pronounced granulomonocytopoiesis-stimulating and SC-mobilizing activity. More potent stimulation of committed precursors against the background of less pronounced activation of polypotent hemopoietic cells is a peculiarity of hemostimulating action of pegylated using electron-beam synthesis nanotechnology granulocytic CSF in comparison with its non-modified analog. The mobilizing effect of pegylated using electron-beam synthesis nanotechnology granulocytic CSF on early progenitor elements surpasses that of non-conjugated cytokine.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
A M
AM
Dygai
G N
GN
Zyuz'kov
V V
VV
Zhdanov
P G
PG
Madonov
E V
EV
Udut
L A
LA
Miroshnichenko
T Yu
TY
Khrichkova
E V
EV
Simanina
L A
LA
Stavrova
A V
AV
Artamonov
A A
AA
Bekarev
D N
DN
Kinsht
A V
AV
Chaikovskiy
T S
TS
Markova
R V
RV
Gurto
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects; D002452:Cell Count; D003520:Cyclophosphamide / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000138:chemical synthesis / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006397:Hematinics / Q000138:chemical synthesis / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D036103:Nanotechnology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D016012:Poisson Distribution; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000494:pharmacology*; D018709:Statistics, Nonparametric
D006397:Hematinics; D007166:Immunosuppressive Agents; C486981:pegylated granulocyte colony-stimulating factor, human; D016179:Granulocyte Colony-Stimulating Factor; D011092:Polyethylene Glycols; D003520:Cyclophosphamide