Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei.
An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.
Department of Biosciences and Informatics, Keio University, Yokohama, Japan.
Keiji
K
Yuki
Mariko
M
Ikeda
Kenji
K
Miyamoto
Osamu
O
Ohno
Kaoru
K
Yamada
Daisuke
D
Uemura
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005223:Fats / Q000037:antagonists & inhibitors* / Q000378:metabolism; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D013237:Stereoisomerism; D014632:Valerian / Q000737:chemistry*
D005223:Fats; D044243:Linoleic Acids, Conjugated; C024347:9-hydroxy-10,12-octadecadienoic acid