Green synthesis and bioactivity of 2-amino-4H-chromen-4-yl-phosphonates.
A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Mekala
M
Rajasekhar
Kunda Uma
KU
Maheswara Rao
Chereddy Syama
CS
Sundar
Nemallapudi Bakthavatchala
NB
Reddy
Sandip Kumar
SK
Nayak
Cirandur Suresh
CS
Reddy
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002384:Catalysis; D005658:Fungi / Q000187:drug effects; D055772:Green Chemistry Technology; D007455:Iodine / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D000890:Anti-Infective Agents; D000975:Antioxidants; D063065:Organophosphonates; D007455:Iodine