Antibodies to N-methyl-D-aspartate glutamate receptors in Creutzfeldt-Jakob disease patients.
Psychiatric symptom can be a prominent feature early in Creutzfeldt-Jakob disease (CJD), which is also common in autoantibody-mediated limbic encephalitis. We hypothesized that anti-neuronal autoantibodies, especially those against N-methyl-D-aspartate glutamate receptors (NMDAR), can also be associated with CJD. Thirteen patients with CJD and 13 patients with limbic encephalitis were enrolled. Immunohistochemistry demonstrated that serum of CJD patients reacted with neuronal components of the rat hippocampus, indicating that those samples contained anti-neuronal antibodies. Enzyme-linked immunosorbent assay revealed that titers of antibodies against peptides of GluN2B subunit of NMDAR were significantly elevated in the serum and cerebrospinal fluid of CJD patients.
Department of Clinical Neuroscience, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. kof@clin.med.tokushima-u.ac.jp
Koji
K
Fujita
Tatsuhiko
T
Yuasa
Yukitoshi
Y
Takahashi
Keiko
K
Tanaka
Wataru
W
Sako
Hidetaka
H
Koizumi
Yasushi
Y
Iwasaki
Mari
M
Yoshida
Yuishin
Y
Izumi
Ryuji
R
Kaji
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism; D006801:Humans; D020363:Limbic Encephalitis / Q000097:blood / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000097:blood / Q000276:immunology* / Q000378:metabolism
D001323:Autoantibodies; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate