Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy.
Cutaneous collagenous vasculopathy is a rare microangiopathy of superficial dermal blood vessels. Patients present with telangiectatic macules, predominantly on the extremities. A skin biopsy specimen is necessary to distinguish cutaneous collagenous vasculopathy from generalized essential telangiectasia. Microscopically, cutaneous collagenous vasculopathy resembles the superficial telangiectasias of generalized essential telangiectasia but additionally shows hyaline material in thickened vessel walls. The amorphous pink material is periodic acid-Schiff-positive and resistant to diastase. We describe a series of four patients with cutaneous collagenous vasculopathy and highlight its clinical and histopathologic features.
Cleveland Clinic - Anatomic Pathology and Dermatology, Cleveland, OH, USA.
Laura M
LM
Burdick
Sara
S
Lohser
Sara
S
Losher
Stephen C
SC
Somach
Steven D
SD
Billings
D000328:Adult; D000368:Aged; D000681:Amylases / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D020405:Dermis / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008297:Male; D055806:Microvessels / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D017445:Skin Diseases, Vascular / Q000378:metabolism / Q000473:pathology*; D013684:Telangiectasis / Q000175:diagnosis
D015415:Biomarkers; D006025:Glycosaminoglycans; D000681:Amylases