Interleukin-1β gene is not associated with preeclampsia in Taiwanese.
OBJECTIVE
To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women.


METHODS
We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction and restriction fragment length polymorphism analysis. The association between the genotype and disease was examined by Chi-square tests.


RESULTS
We found no association between the two polymorphic sites of interleukin-1β gene and preeclampsia. No significant differences were detected in genotype distributions and allele frequencies of the AvaI polymorphism at position -511 in the promoter region and the TaqI polymorphism at position +3953 within Exon 5.


CONCLUSIONS
Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women.
Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.
Lin
L
Kang
Chung-Hwan
CH
Chen
Chen-Hsiang
CH
Yu
Chiung-Hsin
CH
Chang
Fong-Ming
FM
Chang
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D013624:Taiwan
D053583:Interleukin-1beta