Dissociation between neuronal activity in sensorimotor cortex and hand movement revealed as a function of movement rate.
It is often assumed that similar behavior is generated by the same brain activity. However, this does not take into account the brain state or recent behavioral history and movement initiation or continuation may not be similarly generated in the brain. To study whether similar movements are generated by the same brain activity, we measured neuronal population activity during repeated movements. Three human subjects performed a motor repetition task in which they moved their hand at four different rates (0.3, 0.5, 1, and 2 Hz). From high-resolution electrocorticography arrays implanted on motor and sensory cortex, high-frequency power (65-95 Hz) was extracted as a measure of neuronal population activity. During the two faster movement rates, high-frequency power was significantly suppressed, whereas movement parameters remained highly similar. This suppression was nonlinear: after the initial movement, neuronal population activity was reduced most strongly, and the data fit a model in which a fast decline rapidly converged to saturation. The amplitude of the beta-band suppression did not change with different rates. However, at the faster rates, beta power did not return to baseline between movements but remained suppressed. We take these findings to indicate that the extended beta suppression at the faster rates, which may suggest a release of inhibition in motor cortex, facilitates movement initiation. These results show that the relationship between behavior and neuronal activity is not consistent: recent movement influences the state of motor cortex and facilitates next movements by reducing the required level of neuronal activity.
Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, Section of Brain Function and Plasticity, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. d.hermes@umcutrecht.nl
Dora
D
Hermes
Jeroen C W
JC
Siero
Erik J
EJ
Aarnoutse
Frans S S
FS
Leijten
Natalia
N
Petridou
Nick F
NF
Ramsey
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000704:Analysis of Variance; D001611:Beta Rhythm / Q000502:physiology*; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D006225:Hand / Q000294:innervation / Q000502:physiology*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009044:Motor Cortex / Q000166:cytology*; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D055815:Young Adult