[Effects of intermittent hypoxia on the responses of genioglossus motor cortex to transcranial magnetic stimulation in rats].
OBJECTIVE
To explore the influence of intermittent hypoxia on the responses of genioglossus motor cortex to transcranial magnetic stimulation.


METHODS
Male Sprague-Dawley rats were randomly divided into a control group and a chronic intermittent hypoxia group. Transcranial magnetic stimulation was applied in genioglossus motor cortex of the 2 groups. The responses of transcranial magnetic stimulation were recorded and analyzed by single factor analysis of variance.


RESULTS
The anterolateral area provided an optimal motor evoked potential response to transcranial magnetic stimulation in the genioglossus motor cortex of the rats. Genioglossus motor evoked potential latency and amplitude were significantly modified by intermittent hypoxic exposure, with a significant decrease in latency (F = 3.294, P < 0.01) at the 1st day [(4.90 ± 0.54) ms] and the 14th day [(4.64 ± 1.71) ms], and an increase in amplitude (F = 1.905, P < 0.05) at the 1st day [(2.28 ± 0.57) mV] and the 7th day [(1.89 ± 0.20) mV].


CONCLUSIONS
Intermittent hypoxia could increase the transcranial magnetic stimulation response of genioglossus motor cortex in rats.
Institue of Respiratory Disease, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ting
T
Li
Wei
W
Wang
De-lei
DL
Kong
Jiao
J
Su
Jian
J
Kang
D000818:Animals; D004576:Electromyography; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D050781:Transcranial Magnetic Stimulation