[Clinical research of 24-hour double-probe pH-metry in the laryngopharyngeal reflux diseases].
OBJECTIVE
To determine the clinical value of 24 h double-probe pH-metry for the diagnosis and treatment of laryngopharyngeal reflux (LPR).


METHODS
According to the pH-metry results (whether the reflux events record in the upper esophagus is more than 6.9), patients of refractory pharyngolaryngitis were divided into LPR and control groups (each of 17 cases). All patients treated with anti-acid therapy and conventional pharyngo-laryngitis therapy. Correlation between pH-metry and the reflux symptom index (RSI), the reflux symptom index (RFI) were analyzed. Changes of the RSI and RFI in different group were calculated in post-treatment.


RESULTS
In the LPR group, the median reflux events of the upright time were higher than the supine time (Z = -3.62, P < 0.01), but the difference was not discovered in the control group (Z = -0.60, P > 0.05). There was no statistical difference between RSI, RSI and RFS with pH-metry, and with moderate concordance (k were 0.47, 0.53, P < 0.01, respectively). Compared to pre-treatment, the RSI and RFI were decreased both in LPR group and control group, Amplitude decreased in LPR group significantly higher than the control groups, with statistical difference (t were 3.74, 3.01, P < 0.01, respectively).


CONCLUSIONS
The 24 h double-probe pH-metry is significant for the anti-acid therapy of LPR.
Department of Otorhinolaryngology Head and Neck Surgery, Ningbo no.1 Hospital, Ningbo 315010, China.
Tianbin
T
OUYANG
Shi-xiong
SX
TANG
Li-tao
LT
ZHANG
Shou-guo
SG
YAO
Xu-qun
XQ
ZHANG
Xu
X
LU
Xing
X
CHEN
D000328:Adult; D050782:Esophageal pH Monitoring; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged