Electrochemistry of metoclopramide at multi-walled carbon nanotube modified electrode and its voltammetric detection.
A simple, sensitive and inexpensive electrochemical method was developed for the determination of metoclopramide (MCP) with a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE). MWNT was dispersed into polyacrylic acid (PAA); the aqueous suspension was then cast on GCE electrodes, forming MWNT-PAA films after evaporation of the solvent. The electrochemical behavior of MCP at the MWNT-modified electrode was investigated in detail. Compared with the bare GCE, the MWNT-modified electrode exhibits electrocatalytic activity to the oxidation of MCP because of the significant oxidation peak-current enhancement. Furthermore, various experimental parameters, such as the solution pH value, the amount of MWNT-PAA suspension and accumulation conditions were optimized for the determination of MCP. Based on the electrocatalytic effect of the MWNT-modified electrode, linear sweep voltammetry (LSV) was developed for the determination of MCP with the linear response in the range from 1.0 × 10(-7) to 1.0 × 10(-5) mol L(-1) and a detection limit of 5.0 × 10(-8) mol L(-1). The method has been successfully applied to the determination of MCP in commercial MCP tablets.
Department of Chemistry, Xinxiang Medical University, Xinxiang, Henan,P R China.
Wei
W
Guo
Mingjiang
M
Geng
Lingyun
L
Zhou
D000180:Acrylic Resins / Q000737:chemistry; D002138:Calibration; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008787:Metoclopramide / Q000032:analysis* / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013607:Tablets
D000180:Acrylic Resins; D037742:Nanotubes, Carbon; D013607:Tablets; C006903:carbopol 940; D008787:Metoclopramide