[Impact on absorption of berberine and palmatine in different compatibilities of Wuji pill].
OBJECTIVE
To observe the impact on absorption of berberine and palmatine in different compatibilities of Wuji pill by the perfused rat intestine-liver preparation.


METHODS
Use L9 (3(4)) orthogonal design table, establish the perfused rat intestine-liver preparation, the twelve Wuji pill compatibilities duodenal administrated, collect the perfusate at different times points for LC-MS detection, calculate the absorbed score, Ka.


RESULTS
Evodiae Fructus and the absorption score, Ka of berberine and palmatine are inverse correlated. The most superior portion which promote the absorption is Coptidis Rhizoma-Evodiae Fructus-Paeoniae Radix Alba 3:1:3.


CONCLUSIONS
Evodiae Fructus suppressed the absorption of berberine and palmatine. With the different portion the absorption also have big different.
China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Beijing 100700, China.
Yiwei
Y
Wang
Yujie
Y
Li
Yanli
Y
Wang
Weipeng
W
Yang
Ying
Y
Chen
Dong
D
Zhang
Qing
Q
Yang
Yingfeng
Y
Zhang
Tao
T
Li
Xiaoxin
X
Zhu
D000818:Animals; D001599:Berberine / Q000378:metabolism* / Q000493:pharmacokinetics; D001600:Berberine Alkaloids / Q000378:metabolism* / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D032086:Evodia / Q000737:chemistry; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051381:Rats
D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D001599:Berberine; C005413:palmatine