A versatile polypeptoid platform based on N-allyl glycine.
N-Allyl glycine N-carboxyanhydride (NCA) was synthesized and polymerized by ring opening polymerization under homo- or heterophase conditions to afford well-defined polypeptoids (M(W) = 1.5-10.5 kg mol(-1), PDI = 1.1-1.4). Poly(N-allyl glycine) demonstrated stimuli-responsive behaviour in water and was readily modified via thiol-ene photochemistry under experimentally benign conditions.
Max Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry, Research Campus Golm, 14424 Potsdam, Germany.
Joshua W
JW
Robinson
Helmut
H
Schlaad
D005998:Glycine / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*; D055668:Photochemical Processes; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014867:Water / Q000737:chemistry
D034444:Peptoids; D011108:Polymers; D013438:Sulfhydryl Compounds; D014867:Water; D005998:Glycine