Chitosan-based intragastric delivery of cefuroxime axetil: development and in-vitro evaluation of mucoadhesive approach.
To have advantages of reduced dosing frequency, improved bioavailability and effective delivery system of Cefuroxime Axetil, a Chitosan based intragastric sustained release microbead formulation of Cefuroxime Axetil was developed. The drug delivery system was prepared by ionotropic gelation of Chitosan in presence of sodium tripolyphosphate as polyanion and optimized by box-behnken experimental design. Response surface methodology was applied to evaluate various vitro characteristics of prepared mucoadhesive microbeads. Multiple independent variables were optimized to achieve responses of interest, thereby to get the desired sustained release profile of Cefuroxime Axetil in gastric environment.
Government College of Pharmacy, Department of Biopharmaceutics, Karad, India. miteshnagar@yahoo.com
Mitesh
M
Nagar
Adhikrao V
AV
Yadav
D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001424:Bacterial Infections / Q000188:drug therapy*; D001682:Biological Availability; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006041:Goats; D006801:Humans; D007421:Intestine, Small / Q000737:chemistry / Q000187:drug effects*; D008863:Microspheres; D009924:Organ Culture Techniques; D011122:Polyphosphates / Q000737:chemistry
D000900:Anti-Bacterial Agents; D011122:Polyphosphates; D048271:Chitosan; C005692:triphosphoric acid; D002444:Cefuroxime; C040738:cefuroxime axetil