Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis.
BACKGROUND
Studies investigating the association between Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and intrahepatic cholangiocarcinoma (ICC) have reported inconsistent findings. We conducted a meta-analysis of epidemiological studies to explore this relationship.


METHODS
A comprehensive search was conducted to identify the eligible studies of hepatitis infections and ICC risk up to September 2011. Summary odds ratios (OR) with their 95% confidence intervals (95% CI) were calculated with random-effects models using Review Manager version 5.0.


RESULTS
Thirteen case-control studies and 3 cohort studies were included in the final analysis. The combined risk estimate of all studies showed statistically significant increased risk of ICC incidence with HBV and HCV infection (OR = 3.17, 95% CI, 1.88-5.34, and OR = 3.42, 95% CI, 1.96-5.99, respectively). For case-control studies alone, the combined OR of infection with HBV and HCV were 2.86 (95% CI, 1.60-5.11) and 3.63 (95% CI, 1.86-7.05), respectively, and for cohort studies alone, the OR of HBV and HCV infection were 5.39 (95% CI, 2.34-12.44) and 2.60 (95% CI, 1.36-4.97), respectively.


CONCLUSIONS
This study suggests that both HBV and HCV infection are associated with an increased risk of ICC.
Department of Hepato-Biliary-Pancreato-Vascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.
Yanming
Y
Zhou
Yanfang
Y
Zhao
Bin
B
Li
Jiyi
J
Huang
Lupeng
L
Wu
Donghui
D
Xu
Jiamei
J
Yang
Jia
J
He
D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D016022:Case-Control Studies; D018281:Cholangiocarcinoma / Q000453:epidemiology / Q000209:etiology / Q000821:virology*; D015331:Cohort Studies; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000821:virology*; D016017:Odds Ratio; D017594:Publication Bias