Encountering premature ovulation during controlled ovarian hyperstimulation in IVF/ICSI cycles.
OBJECTIVE
To report successful pregnancy outcomes in three cases of documented premature ovulation in intracytoplasmic sperm injection (ICSI) cycles.


METHODS
Three cases of premature ovulation were noted during the oocyte retrieval procedures in in vitro fertilization (IVF)/ICSI cycles with gonadotropin-releasing hormone antagonist protocol. Immature oocytes were aspirated from the remaining small and medium-sized follicles with in vitro maturation performed in two cases. All three cases achieved successful pregnancy with documented live birth after ICSI.


CONCLUSIONS
This is the first ever report of successful pregnancy outcome after documented premature ovulation. Fertilizable oocytes and successful pregnancies can still be obtained from the remaining small and medium-sized follicles after premature ovulation and used for ICSI.
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Frank Shao-Ying
FS
Wu
Robert Kuo-Kuang
RK
Lee
Yuh-Ming
YM
Hwu
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D008297:Male; D009865:Oocytes / Q000473:pathology*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010060:Ovulation; D010062:Ovulation Induction; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D014463:Ultrasonography