[Effect of H-uvulopalatopharyngoplasty on endothelium dependent flow-mediated dilation in patients with moderate to severe obstructive sleep apnea syndrome].
OBJECTIVE
This study evaluates the effects of H-uvulopalatopharyngoplasty (H-UPPP) on endothelial function by endothelium dependent flow-mediated dilation(FMD) in patients with moderate to severe obstructive sleep apnea syndrome (OSAHS).


METHODS
Forty-five healthy subjects and 49 patients with moderately to severe OSAHS who desired H-UPPP were prospectively enrolled. FMD was measured by high-resolution B-mode ultrasonography. All subjects participated in sleep studies. These studies were repeated 6 months after H-UPPP in patients with moderately to severe OSAHS.


RESULTS
There was significant difference in FMD between patients with moderately to severe OSAHS and healthy subjects at baseline (6.5 +/- 2.1)% vs (11.2 +/- 3.1)% (P < 0.01). FMD increased from (6.5 +/- 2.1)% to (9.7 +/- 2.7)% 6 months after H-UPPP in patients with moderately to severe OSAHS (P < 0.01).


CONCLUSIONS
FMD is decreased in patients with moderately to severe OSAHS, H-UPPP treatment of these patients leads to improvement of FMD.
Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Haibo
H
Yang
Ying
Y
Wang
Mingmin
M
Dong
D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010159:Palate / Q000601:surgery*; D010614:Pharynx / Q000502:physiology / Q000601:surgery*; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000601:surgery*; D014609:Uvula / Q000601:surgery