Chronic graft versus host disease with small bowel obstruction after unrelated hematopoietic stem cell transplantation in a patient with acute myeloid leukemia.
Chronic graft versus host disease (GVHD) is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), but simultaneous small bowel obstruction is rare. Here, we report a child with acute myeloid leukemia who received an allogeneic HSCT from an unrelated matched donor. After HSCT, the patient developed severe chronic GVHD involving the small intestine, leading to obstruction of the terminal ileum. Small bowel resection was performed, and the symptoms improved without severe complications. Bowel obstruction should be considered as a possible complication of chronic GVHD; surgery may be a valuable corrective measure.
Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Ju Young
JY
Yoon
Hyery
H
Kim
Hyoung Jin
HJ
Kang
Kyung Duk
KD
Park
Hee Young
HY
Shin
Hyo Seop
HS
Ahn