Increasing effect of an oral intake of L-hydroxyproline on the soluble collagen content of skin and collagen fragments in rat serum.
We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the soluble collagen content of the skin had increased, and the serum concentration of collagen peptides was correlated with the skin content of soluble collagen. This result suggests that oral Hyp augmented collagen metabolism.
Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD., Ibaraki, Japan.
Mami
M
Aoki
Kouzou
K
Suto
Miho
M
Komatsu
Ayako
A
Kamimura
Koji
K
Morishita
Motoo
M
Yamasaki
Toshifumi
T
Takao
D000284:Administration, Oral; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006909:Hydroxyproline / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D051381:Rats; D011916:Rats, Inbred F344; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012995:Solubility
D010446:Peptide Fragments; D003094:Collagen; D006909:Hydroxyproline