A new antimycobacterial furanolignan from Leucophyllum frutescens.
Bioassay-guided fractionation of the minor active fractions obtained from the root bark of Leucophyllumfrutescens (Berl.) I. M. Johnst. led to isolation from the n-hexane extract of a new compound with moderate activity against the H37Rv Mycobacterium tuberculosis strain (MIC 63 microg/mL), and low cytotoxicity, as shown by the IC5o against Vero cells. The compound was identified by 1D/2D NMR spectroscopy a s2',5"-dimethoxysesamin.
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo León, P.O. Box 2316, Sucursal Tecnológico, Monterrey, N.L., 64841 México.
Blanca
B
Alanís-Garza
Ricardo
R
Salazar-Aranda
Rosalba
R
Ramírez-Durón
Elvira
E
Garza-González
Noemí
N
Waksman de Torres
D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D028083:Scrophulariaceae / Q000737:chemistry*
D000995:Antitubercular Agents; D017705:Lignans