Structural characteristics of adenohypophysis in hypertensive ISIAH rats in early ontogeny.
Comparative morphological study of the adenohypophysis was conducted in 3-week-old normotensive WAG and hypertensive ISIAH rats (prehypertension period) to elucidate the role of the adenohypophysis in the development of essential hypertension. Morphometric analysis revealed ultrastructural signs of functional activation of somatotrophs, gonadotrophs, and corticotrophs in ISIAH rats. These peculiarities of structural organization of adenohypophysis in hypertensive rats can attest to enhanced response of the hypothalamic-pituitary-adrenal axis in these animals to natural stress associated with their transition to independent feeding. Increased stress sensitivity during the prehypertensive period of postnatal ontogeny contributes to the development of arterial hypertension.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. ibuzueva@physiol.ru
I I
II
Buzueva
E E
EE
Filyushina
M D
MD
Shmerling
A L
AL
Markel
G S
GS
Jacobson
D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology* / Q000502:physiology; D001837:Body Weights and Measures; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005247:Feeding Behavior / Q000502:physiology; D006056:Golgi Apparatus / Q000648:ultrastructure; D006973:Hypertension / Q000503:physiopathology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D010903:Pituitary Gland, Anterior / Q000033:anatomy & histology*; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology* / Q000502:physiology; D017208:Rats, Wistar