Gonadotroph pituitary macroadenoma inducing ovarian hyperstimulation syndrome: successful response to octreotide therapy.
We report a young woman with spontaneous ovarian hyperstimulation syndrome (OHSS), headaches, visual field defect and pituitary macroadenoma. She underwent transsphenoidal surgery with remission of OHSS. Immunohistochemical staining was positive for β-FSH and β-LH. Recurrence occurred after four years. The patient was treated with octreotide administration and conventional radiation therapy. Octreotide was effective in normalizing estradiol levels and resolving OHSS. This is a rare description of octreotide administration as an effective treatment modality of OHSS caused by gonadotropin-secreting pituitary adenomas.
Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece. olgakarapanou@yahoo.com
Olga
O
Karapanou
Marinella
M
Tzanela
Nikolaos
N
Tamouridis
Stylianos
S
Tsagarakis
D000328:Adult; D005260:Female; D037201:Follicle Stimulating Hormone, beta Subunit / Q000378:metabolism; D052681:Gonadotrophs / Q000378:metabolism*; D006801:Humans; D015282:Octreotide / Q000008:administration & dosage; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology* / Q000473:pathology; D010902:Pituitary Gland / Q000000981:diagnostic imaging; D010911:Pituitary Neoplasms / Q000150:complications* / Q000473:pathology; D014463:Ultrasonography
D037201:Follicle Stimulating Hormone, beta Subunit; D015282:Octreotide