Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepines.
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in numerous important natural products and clinical drugs.
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
Kai
K
Gao
Bo
B
Wu
Chang-Bin
CB
Yu
Qing-An
QA
Chen
Zhi-Shi
ZS
Ye
Yong-Gui
YG
Zhou
D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry*; D001570:Benzodiazepinones / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D001570:Benzodiazepinones; D007097:Imines; D001569:Benzodiazepines; D007495:Iridium