A "catch-react-release" method for the flow synthesis of 2-aminopyrimidines and preparation of the Imatinib base.
The development of a monolith-supported synthetic procedure is reported, taking advantage of flow processing and the superior flow characteristics of monolithic reagents over gel-phase beads, to allow facile access to an important family of 2-aminopyrimidine derivatives. The process has been successfully applied to a key precursor on route to Imatinib (Ar = 3-pyridyl, R(1) = 2-methyl-5-nitrobenzyl, R(2) = H).
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Richard J
RJ
Ingham
Elena
E
Riva
Nikzad
N
Nikbin
Ian R
IR
Baxendale
Steven V
SV
Ley