Isolation of antitrypanosomal compounds from Vitis repens, a medicinal plant of Myanmar.
Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol (1), 11-O-acetyl bergenin (2), and stigmast-4-en-3-one (3). The compounds were examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Resveratrol showed antitrypanosomal activity with an IC50 value of 0.13 microM, whereas 11-O-acetyl bergenin and stigmast-4-en-3-one exhibited IC50 values of 0.17 and 0.15 microM, respectively.
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
Khine Swe
KS
Nyunt
Ahmed
A
Elkhateeb
Yusuke
Y
Tosa
Kensuke
K
Nabata
Ken
K
Katakura
Hideyuki
H
Matsuura
D002052:Myanmar; D010936:Plant Extracts / Q000032:analysis*; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D014345:Trypanosoma / Q000187:drug effects; D027843:Vitis / Q000737:chemistry*
D010936:Plant Extracts; D014344:Trypanocidal Agents