Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial.
Rapeseeds are naturally rich in cardioprotective micronutrients but refining leads to substantial losses or the production of undesirable compounds. The Optim'Oils European project proposed innovative refining conditions to produce an optimized rapeseed oil enriched in micronutrients and low in trans linolenic acid. We aimed to investigate cardioprotective properties of this Optimized oil. In a randomized, double-blind, controlled, cross-over study, 59 healthy normolipidaemic men consumed either Optimized or Standard rapeseed oils (20 g/d) and margarines (22 g/d) for 3 weeks. The Optimized oil reduced the trans FA concentration (p=0.009) and increased the contents of alpha-tocopherol (p=0.022) and coenzyme Q10 (p<0.001) in comparison with the Standard oil. Over the 3-week trial, Total-/HDL-cholesterol and LDL-/HDL-cholesterol were increased by 4% (p<0.05) with the Standard oil consumption whereas none of them rose with the Optimized rapeseed oil which increased the HDL-cholesterol and ApoA1 plasma content (+2%, NS and +3%, p<0.05 respectively). The effects observed on the plasma HDL-cholesterol levels (p=0.059), the Total-/HDL-cholesterol ratio (p=0.092), and on the ApoA1 concentrations (p=0.060) suggest an improvement of the cholesterol profile with the Optimized rapeseed oil. Finally, the Optimized oil reduced the plasma content of LDLox (-6%, NS), this effect being significantly different from the Standard oil (p=0.050). In conclusion, reasonable intake of an Optimized rapeseed oil resulting from innovative refining processes and enriched in cardioprotective micronutrients represent a relevant nutritional approach to prevent the risk of cardiovascular diseases by improving the cholesterol profile and reducing LDL oxidation.
Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France. cecile.gladine@clermont.inra.fr
Cécile
C
Gladine
Nicole
N
Combe
Carole
C
Vaysse
Bruno
B
Pereira
Alain
A
Huertas
Serafina
S
Salvati
Anne
A
Rossignol-Castera
Noël
N
Cano
Jean-Michel
JM
Chardigny
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D029741:Brassica rapa / Q000737:chemistry; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005229:Fatty Acids, Monounsaturated; D005527:Food, Fortified / Q000032:analysis*; D006801:Humans; D008297:Male; D008383:Margarine / Q000032:analysis; D018977:Micronutrients / Q000008:administration & dosage* / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010840:Phytosterols / Q000097:blood; D010938:Plant Oils / Q000737:chemistry*; D000074262:Rapeseed Oil; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood; D014810:Vitamin E / Q000097:blood; D017962:alpha-Linolenic Acid / Q000008:administration & dosage* / Q000097:blood
D001053:Apolipoproteins; D015415:Biomarkers; D005229:Fatty Acids, Monounsaturated; D018977:Micronutrients; D010840:Phytosterols; D010938:Plant Oils; D000074262:Rapeseed Oil; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D014451:Ubiquinone; D014810:Vitamin E; D008383:Margarine; D002784:Cholesterol; C024989:coenzyme Q10