Biological evaluation of dodecaborate-containing L-amino acids for boron neutron capture therapy.
To develop a boron carrier for practical purposes, new boron-containing amino acids with an undecahydro-closo-dodecaboranylthio ([(10)B(12)H(11)S](2-)-) unit in the side chain of the α-amino acid have already been designed and synthesized. In the present paper, cytotoxicity, the incorporation amounts into tumor cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as boron carriers. Furthermore, the microdistribution of the amino acids in tumor cells was established.
Research Center of Boron Neutron Capture Therapy, Research Organization for the 21st Century, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku 599-8531, Sakai, Japan. y0shi_hattori@riast.osakafu-u.ac.jp
Yoshihide
Y
Hattori
Shintaro
S
Kusaka
Mari
M
Mukumoto
Kouki
K
Uehara
Tomoyuki
T
Asano
Minoru
M
Suzuki
Shin-ichiro
S
Masunaga
Koji
K
Ono
Shinji
S
Tanimori
Mitsunori
M
Kirihata
D000596:Amino Acids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001880:Boranes / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D051381:Rats; D013237:Stereoisomerism
D000596:Amino Acids; D001880:Boranes