High risk for essential hypertension in males conferred by g.15241A>G polymorphism in intron 3 of AGT gene.
A total of 180 hypertensive and 188 normotensive subjects were studied for demographic features and for variations in exon 4 including exon-intron boundary of AGT gene using single-strand conformation polymorphism analysis. Sequencing of the samples showing mobility shift revealed a single-nucleotide polymorphism variant g.15241A>G in intron 3 of the gene. The polymorphism was consistent with Hardy-Weinberg equilibrium in both the cases and the controls. Although the genotype distribution and allele frequencies did not differ significantly in general, high risk was observed for males with G allele (OR = 2.08; 95% CI = 1.02-4.21; P = .04). Similar results were obtained when the genotypes were tested in dominant model wherein G allele carriers were found to be at twofold risk for developing essential hypertension (OR = 2.09; 95% CI = 0.99-4.41; P = 0.05). This report is the first one in the literature showing association of g.15241A>G polymorphism with a clinical condition.
Department of Genetics, Osmania University, Tarnaka, Hyderabad 500007, India.
Gunda
G
Padma
Charita
C
Bhupatiraju
Bhyravavajhala
B
Srinivas
Tirunilai
T
Padma
D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics*; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018807:Polymorphism, Single-Stranded Conformational / Q000235:genetics*; D012307:Risk Factors; D017678:Sex Distribution
D000808:Angiotensinogen