Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom.
Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, CP: 486, CEP: 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Francisco S
FS
Schneider
Maria C
MC
Starling
Clara G
CG
Duarte
Ricardo
R
Machado de Avila
Evanguedes
E
Kalapothakis
Walter
W
Silva Suarez
Benigno
B
Tintaya
Karin
K
Flores Garrido
Silvia
S
Seraylan Ormachea
Armando
A
Yarleque
César
C
Bonilla
Carlos
C
Chávez-Olórtegui
D000818:Animals; D000997:Antivenins / Q000494:pharmacology*; D015153:Blotting, Western; D017837:Bothrops; D003429:Cross Reactions; D004353:Drug Evaluation, Preclinical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006470:Hemorrhage / Q000503:physiopathology; D008297:Male; D051379:Mice; D010568:Peru; D059748:Proteolysis / Q000187:drug effects; D012910:Snake Venoms / Q000737:chemistry*
D000997:Antivenins; D012910:Snake Venoms