Congenital leukemia with leukemia cutis: a case report.
Congenital leukemia is a rare malignancy. Most of the neonatal cases reported have acute nonlymphoblastic leukemia. A number of chromosomal translocations and deletions have been found carrying an unfavorable prognosis. We report a newborn with congenital leukemia with leukemia cutis. The patient died before chemotherapy was started. The chromosome analysis showed 46, XY, t (4:11) (q21;q23). FISH for 11q23 MLL gene rearrangement showed positivity in 58% of interphase cells examined. Flow cytometry was reported with precursor B-cell acute lymphoblastic leukemia. This is a rare case of congenital leukemia with findings associated with poor prognosis.
Neonatology section, Department of Pediatrics, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
Abymael
A
Frontanes
Freddie
F
Montalvo
Marta
M
Valcárcel
D006801:Humans; D007231:Infant, Newborn; D017254:Leukemic Infiltration; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital* / Q000473:pathology*; D012867:Skin / Q000473:pathology*