Combining piracetam and lithium salts: ionic co-crystals and co-drugs?
Mechanochemical reaction of solid piracetam with the inorganic salts LiCl and LiBr yields ionic co-crystals which are also co-drugs, characterized by markedly different thermal properties with respect to pure components, also depending on the method for preparation and/or conditions of measurements; single crystal and powder X-ray diffraction at variable temperatures, DSC, TGA, hot stage microscopy (HSM) and intrinsic dissolution rate have been used to fully characterize the solid products.
Dipartimento di Chimica G. Ciamician, Università degli Studi di Bologna, via Selmi 2, 40126 Bologna, Italy.
Dario
D
Braga
Fabrizia
F
Grepioni
Lucia
L
Maini
Davide
D
Capucci
Saverio
S
Nanna
Johan
J
Wouters
Luc
L
Aerts
Luc
L
Quéré
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D007477:Ions; D008094:Lithium / Q000737:chemistry*; D008958:Models, Molecular; D018696:Neuroprotective Agents / Q000737:chemistry; D010889:Piracetam / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction
D007477:Ions; D018696:Neuroprotective Agents; D008094:Lithium; D010889:Piracetam