Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study.
BACKGROUND
To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study).


METHODS
Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not.


RESULTS
384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia.


CONCLUSIONS
In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.
Italian Foundation for the study of Schizophrenia, Rome, Italy.
Roberto
R
Brugnoli
Diego
D
Novick
Josep Maria
JM
Haro
Andrea
A
Rossi
Marco
M
Bortolomasi
Sonia
S
Frediani
Giuseppe
G
Borgherini
D000328:Adult; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients / Q000523:psychology*; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications; D012565:Schizophrenic Psychology; D012737:Sex Factors; D059020:Suicidal Ideation; D013405:Suicide / Q000523:psychology*