Ulcerating and stenosing enteropathy treated with misoprostol:  a case report with analysis of prostaglandin metabolism.
A case of a 40-year-old man with chronic anaemia because of nonspecific ulcerating and stenosing enteropathy is presented. The diagnosis was made on the basis of capsule endoscopy, histology of resected ileum and no use of NSAIDs. He showed a clinical response to treatment with misoprostol, and therefore, he was investigated for a possible impairment in eicosanoid biosynthesis compared with healthy controls. No deficient synthesis of prostacyclin, prostaglandin E2 and thromboxane was found on examination of metabolites in blood and urine. This suggests a normal release of arachidonic acid from phospholipids. Ex-vivo cyclooxygenase (COX) assays showed normal COX-1 and COX-2 activities. The clinical response to treatment with the prostaglandin E1 analogue misoprostol suggests a defective prostaglandin E synthesis in the intestinal mucosa.
Department of Medical Gastroenterology, Odense University Hospital, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. troels.havelund@ouh.regionsyddanmark.dk
Troels
T
Havelund
Boye L
BL
Jensen
Pernille J
PJ
Vinholt
Birte
B
Engvad
Jane
J
Stubbe
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000209:etiology*; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D016595:Misoprostol / Q000627:therapeutic use*; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood; D011453:Prostaglandins / Q000096:biosynthesis*; D014456:Ulcer / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism
D011453:Prostaglandins; D016595:Misoprostol; D011451:Prostaglandin-Endoperoxide Synthases