Portuguese recommendations for the use of biological therapies in children and adolescents with juvenile idiopathic arthritis--December 2011 update.
OBJECTIVE
To update the Portuguese recommendations in order to assist the rational and safe prescribing of biological therapies in children and adolescents with Juvenile Idiopathic Arthritis (JIA) as more evidence and experience with these drugs are available.


METHODS
The recommendations were formulated by Rheumatologists and Pediatricians, with experience in Pediatric Rheumatology, based on literature evidence and consensus opinion. The evidence was sought through a MEDLINE search. The retrieved results were discussed and a set of recommendations proposed. All propositions were extensively debated and the final recommendations formulated.


RESULTS
A consensus was achieved regarding the eligibility, response criteria, maintenance of biologic thera py, and procedures in case of non-response. Also, specific recommendations concerning safety procedures before and while on biologic therapies were formulated.


CONCLUSIONS
Thirteen recommendations for guidance biological therapy in children and adolescents with JIA were developed using both evidence-based and expert consensus. These recommendations will be updated as more evidence becomes available and more biological therapies are licensed.
Serviço de Reumatologia, Hospital Garcia de Orta, Av Prof Torrado da Silva, 2800 Almada, Portugal. mjps@netvisao.pt
Maria José
MJ
Santos
Helena
H
Canhão
Marta
M
Conde
João Eurico
JE
Fonseca
Ana Filipa
AF
Mourão
Filipa
F
Ramos
Lúcia
L
Costa
Margarida Paula
MP
Ramos
Marta
M
Cabral
Paula
P
Estanqueiro
Sónia
S
Melo-Gomes
Manuel
M
Salgado
José
J
Melo-Gomes
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000628:therapy*; D001691:Biological Therapy / Q000592:standards*; D002648:Child; D006801:Humans