Three triterpenoid saponins from the roots of Polygala japonica Houtt.
Three new triterpenoid saponins polygalasaponins LI-LIII (1-3) with two acylation groups in oligosaccharide chain, together with three known saponins were isolated from the roots of Polygala japonica Houtt. (4-6). The neuroprotective effects of these compounds on neuron-like PC12 cells were evaluated in vitro. Compounds 5 and 6 show neuroprotective effects in Aβ₂₅₋₃₅ model at the concentration of 10 μM.
State Key Laboratory of Bioactive Substance and Function of NaturalMedicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Chuangjun
C
Li
Jing
J
Fu
Jingzhi
J
Yang
Dongming
D
Zhang
Yuhe
Y
Yuan
Naihong
N
Chen
D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016716:PC12 Cells; D010446:Peptide Fragments / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C074636:amyloid beta-protein (25-35); C577176:polygalasaponin LI; C577177:polygalasaponin LII; C577178:polygalasaponin LIII