Genes and chronic obstructive pulmonary disease.
Although much remains to be done, recent advances and the advent of new methodologies are promising and should yield increased understanding of the genetic and epigenetic mechanisms influencing the pathogenesis of COPD, both related and unrelated to severe AAT deficiency. Such understanding should ultimately be translated into novel approaches to prevent, diagnose, and treat COPD.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA.
Marilyn G
MG
Foreman
Michael
M
Campos
Juan C
JC
Celedón
D044127:Epigenesis, Genetic; D005541:Forced Expiratory Volume / Q000235:genetics; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014797:Vital Capacity / Q000235:genetics; D000515:alpha 1-Antitrypsin / Q000235:genetics*; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
D005819:Genetic Markers; C043392:SERPINA1 protein, human; D000515:alpha 1-Antitrypsin