A tandem Heck-aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines.
A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.
Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Ke
K
Chen
Sumod A
SA
Pullarkat
D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D002626:Chemistry, Pharmaceutical; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
D000588:Amines; D007211:Indoles; D010165:Palladium; C057812:indoline