[Fast-track surgery accelerates the recovery of postoperative humoral immune function in elective operation for colorectal carcinoma: a randomized controlled clinical trial].
OBJECTIVE
To explore the effects of fast-track surgery on postoperative humoral immune function in patients undergoing elective colorectal resection.


METHODS
Seventy patients with colorectal carcinoma requiring colorectal resection were randomized into fast-track group (n = 35) and conventional care group (n = 35). The clinical parameters and markers of humeral immune function were evaluated in both groups postoperatively.


RESULTS
Sixty-two patients finally completed the study, including 32 in the fast-track group and 30 in the conventional care group. There was a significantly faster recovery of postoperative humoral immunity: blood levels of globulin (24.1 ± 2.4 vs 22.1 ± 3.3 g/L, P = 0.025), immunoglobulin G (10.79 ± 2.39 vs 8.66 ± 2.09 g/L, P = 0.007) and complement 4 (0.24 ± 0.09 vs 0.17 ± 0.05 g/L, P = 0.035) at Day 3 postoperation were higher in the fast-track group than in the conventional care group. And there was also a significantly shorter length of postoperative stay (6.0 ± 1.0 vs 11.7 ± 3.8 d, P < 0.001) in patients undergoing fast-track rehabilitation.


CONCLUSIONS
Fast-track surgery accelerates the recovery of postoperative humoral immune function in elective surgery for colorectal carcinoma with a shorter length of postoperative hospital stay.
Department of Gastrointestinal & Pancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Dong-jie
DJ
Yang
Sheng
S
Zhang
Wei-ling
WL
He
Wen-qi
WQ
Huang
Shi-rong
SR
Cai
Chuang-qi
CQ
Chen
Jin-ping
JP
Ma
Xin-ming
XM
Song
Chang-hua
CH
Zhang
Yu-long
YL
He
Wen-hua
WH
Zhan
D000368:Aged; D000917:Antibody Formation / Q000276:immunology; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome