Relationship between dietary factors and prostate-specific antigen in healthy men.
BACKGROUND
There is little evidence indicating whether dietary factors influence prostate-specific antigen (PSA) concentrations. We examined whether nutritional factors, including energy, protein, fat, and carbohydrate intake were associated with PSA in healthy men.


METHODS
We investigated 13,594 men aged 50 years and over who visited a hospital for a routine health checkup between 2003 and 2007. Dietary intake was assessed using a food frequency questionnaire. We performed a multiple linear regression to examine the association between PSA and dietary intake.


RESULTS
After controlling for age, body mass index, and physical activity, PSA was significantly negatively associated with percent protein intake (p for trend < 0.001). Compared with the lowest quintile, PSA was 5.8% lower (95% CI: -8.9 to -2.5%) in the highest quintile. We also observed a significant positive association between percent fat intake and PSA concentration (p for trend 0.043). PSA was 3.4% greater (95% CI: 0-6.9%) among men in the highest quintile compared with those in the lowest quintile.


CONCLUSIONS
Men who had a lower percent protein intake and higher percent fat intake had an elevated PSA level, although the magnitude of these associations was small.
Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan. ns-waki@med.teikyo-u.ac.jp
Kazuhiro
K
Ohwaki
Fumiyasu
F
Endo
Yuko
Y
Kachi
Kazunori
K
Hattori
Osamu
O
Muraishi
Mariko
M
Nishikitani
Eiji
E
Yano
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D004032:Diet; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D009765:Obesity / Q000097:blood* / Q000150:complications; D050177:Overweight; D017430:Prostate-Specific Antigen / Q000096:biosynthesis*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis; D012044:Regression Analysis
D017430:Prostate-Specific Antigen