Four new dilignans from the roots of Wikstroemia indica.
Phytochemical investigation of the roots of Wikstroemia indica led to the isolation of four new dilignans (1-4). Their structures were established on the basis of the spectroscopic data including UV, IR, high resolution-electron ionization-mass spectrometry (HR-ESI-MS), 1D- and 2D-NMR (1H-1H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY)). These dilignans were screened for their in vitro antiviral activities against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay.
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, China.
Guo-Cai
GC
Wang
Xiao-Li
XL
Zhang
Yi-Fei
YF
Wang
Guo-Qiang
GQ
Li
Wen-Cai
WC
Ye
Yao-Lan
YL
Li
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D032365:Wikstroemia / Q000737:chemistry*
D000998:Antiviral Agents