Lyophilized aspirin with trehalose may decrease the incidence of gastric injuries in healthy dogs.
Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.
Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo, Tokyo, Japan.
Lee-Shuan
LS
Lin
Yuko
Y
Kayasuga
Nobuyuki
N
Shimohata
Hiroyuki
H
Kamata
Shigeki
S
Suzuki
Ryosuke
R
Echigo
Manabu
M
Mochizuki
Ung-Il
UI
Chung
Nobuo
N
Sasaki
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D005612:Freeze Drying / Q000662:veterinary*; D005773:Gastroscopy / Q000662:veterinary; D008297:Male; D018709:Statistics, Nonparametric; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D014199:Trehalose / Q000008:administration & dosage / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014199:Trehalose; D001241:Aspirin