Azido carbonyl compounds as DNA cleaving agents.
Irradiation of azido carbonyl compounds using UV light (≥310 nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of UV light (≥350 nm) and also binding studies revealed that they bind to ct-DNA by weak intercalation mode.
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
Nilanjana
N
Chowdhury
Sansa
S
Dutta
S
S
Karthick
Anakuthil
A
Anoop
Swagata
S
Dasgupta
N D
ND
Pradeep Singh
D000098:Acetophenones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001386:Azides / Q000737:chemistry*; D002417:Cattle; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage / Q000187:drug effects*; D004996:Ethidium / Q000737:chemistry; D013329:Structure-Activity Relationship
D000098:Acetophenones; D001386:Azides; D004247:DNA; D004996:Ethidium