[Prognostic value of MACC1 and c-met expressions in non-small cell lung cancer].
BACKGROUND
It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC).


METHODS
MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry.


RESULTS
MACC1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue (P<0.001). MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages (P<0.05) of NSCLC, but not with sex, age, smoking, and histological classification (P>0.05). In addition, a positive correlation between MACC1 and c-met expressions was observed (r=0.403, P<0.001). The result from the Kaplan-Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions (P<0.05). The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC (P=0.026).


CONCLUSIONS
MACC1 and c-met have an important function in the differentiation, invasion, and metastasis of NSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC.
Department of Oncology, the Second Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Xingsheng
X
Hu
Xi
X
Fu
Shimin
S
Wen
Xinyi
X
Zou
Yusong
Y
Liu
D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D012044:Regression Analysis; D016019:Survival Analysis; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*
C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D019859:Proto-Oncogene Proteins c-met