Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce α(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells".
Martin C
MC
Michel
Paul A
PA
Insel
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology*; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
D018341:Receptors, Adrenergic, alpha-2; D000242:Cyclic AMP; D020827:rap1 GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein