[Role of enteral nutrition in correction of protein-energy metabolism and quality of life indices in liver cirrhosis of viral etiology].
The aim of this work is to improve the efficiency of treatment and life quality of patients with HCV hepatic cirrhosis (HC) Class C by means of correction of protein-energy insufficiency (PEI) using enteral nutritive mixtures with branched-chain amino acids (BCAA). OBJECT AND METHODS OF RESEARCH: A randomized prospective controlled open research of the efficiency of therapy with enteral nutritive mixtures with BCAA for patients with HCV hepatic cirrhosis Class C (score: 10-12) was conducted. It evaluated life quality of the patients (by questionnaire SF-36), the degree of hepatic encephalopathy (by number connection test) as well as the protein-energy insufficiency indexes (weight index, arm muscles circumference, skin-fat fold for triceps and albumin).


RESULTS
Nutritive support with BCAA prevents progression of protein-energy insufficiency, improves functionality class of patients with HCV hepatic cirrhosis Class C and reduces severity of hepatic encephalopathy, p < 0.003. Enteral nutrition with BCAA improves life quality of patients with HCV hepatic cirrhosis Class C, p < 0.012.


CONCLUSIONS
Enteral nutrition with BCAA for patients with HCV hepatic cirrhosis Class C (score: 10-12) improves treatment efficiency and is safe.
I B
IB
Khlynov
T V
TV
Likovskaia
M V
MV
Chikunova
D004044:Dietary Proteins / Q000008:administration & dosage; D004734:Energy Metabolism; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006526:Hepatitis C / Q000378:metabolism / Q000628:therapy / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011502:Protein-Energy Malnutrition / Q000628:therapy*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D004044:Dietary Proteins