Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines.
A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH·) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.
Department of Chemistry, Faculty of Arts and Sciences, Giresun University, Giresun, Turkey. baharsokmen@yahoo.com
Bahar Bilgin
BB
Sokmen
Gulsah
G
Aydin
Arzu
A
Gumus
Seref
S
Karadeniz
Halil Ibrahim
HI
Ugras
Refiye
R
Yanardag
Umit
U
Cakır
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000975:Antioxidants; D003374:Coumarins; D004791:Enzyme Inhibitors; D010196:Pancreatic Elastase