Prokaryotic Nε-lysine acetylomes and implications for new antibiotics.
Protein Nε-acetylation, a post-translational modification widespread in eukaryotes and prokaryotes, has been intensively explored due to its crucial roles in multitudinous physiologic events including transcriptional regulation, metabolic regulation, etc. The particular hotspot is the relationship between acetylation and metabolic regulation. Protein acetylation major types and functions thereof, prokaryotic acetyltransferase, deacetylases, and acetylation sites of enzymes related to glycometabolism, together with the cross-talk between acetylation and other modification, such as the phosphorylation were summarized, with emphases on those from Mycobacteria.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
Longxiang
L
Xie
Wu
W
Li
Jianping
J
Xie
D000107:Acetylation; D051046:Amino-Acid N-Acetyltransferase / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D002633:Chemotaxis; D004789:Enzyme Activation; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) / Q000235:genetics / Q000378:metabolism; D006019:Glycolysis; D007522:Isocitrate Lyase / Q000235:genetics / Q000378:metabolism; D008239:Lysine / Q000378:metabolism*; D009161:Mycobacterium / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); D051046:Amino-Acid N-Acetyltransferase; D007522:Isocitrate Lyase; D008239:Lysine