Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants.
Multidrug-resistant tuberculosis (MDR-TB) and TB-HIV co-infection have become a great threat to global health. However, the last truly novel drug that was approved for the treatment of TB was discovered 40 years ago. The search for new effective drugs against TB has never been more intensive. Natural products derived from microbes and medicinal plants have been an important source of TB therapeutics. Recent advances have been made to accelerate the discovery rate of novel TB drugs including diversifying strategies for environmental strains, high-throughput screening (HTS) assays, and chemical diversity. This review will discuss the challenges of finding novel natural products with anti-TB activity from marine microbes and plant medicines, including biodiversity- and taxonomy-guided microbial natural products library construction, target- and cell-based HTS, and bioassay-directed isolation of anti-TB substances from traditional medicines.
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Xueting
X
Liu
Caixia
C
Chen
Wenni
W
He
Pei
P
Huang
Miaomiao
M
Liu
Qian
Q
Wang
Hui
H
Guo
Krishna
K
Bolla
Yan
Y
Lu
Fuhang
F
Song
Huanqin
H
Dai
Mei
M
Liu
Lixin
L
Zhang
D000995:Antitubercular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D057166:High-Throughput Screening Assays; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D012623:Seawater / Q000382:microbiology*
D000995:Antitubercular Agents; D001688:Biological Products