Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.
BACKGROUND
Microglia, one of the glial cells, play important roles in various brain pathologies including psychiatric disorders. In addition, microglia have recently been proved to monitor synaptic reactions via direct-touching even in normal brain. Human microglia may modulate various social/mental functions, while microglial social/mental roles remain unresolved especially in healthy humans. There is no known drug with the specific effect of modulating microglia. Therefore, using minocycline, a tetracycline antibiotic and the most famous microglial inhibitor, is one of the best alternative approaches to clarify microglial functions on human social/mental activities.


RESULTS
We conducted a double-blind randomized trial of trust game, a monetary decision-making experiment, with ninety-nine human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline. Our previous pilot trial indicated a positive effect of minocycline, while the underlying mechanisms were not clarified. Therefore, in this trial with larger samples, we additionally measured the effects of anxiety and personality. The monetary score in trust game was significantly lower in the minocycline group. Interestingly, participants' ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness.


CONCLUSIONS
Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and furthermore that personality and social behaviors might be modulated by microglia. Early-life events may activate human microglia, establish a certain neuro-synaptic connection, and this formation may determine each human's personality and personality- oriented social behaviors in later life. To explore these mechanisms, further translational research is needed.


BACKGROUND
UMIN clinical trial center UMIN000004803.
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takahiro@npsych.med.kyushu-u.ac.jp
Takahiro A
TA
Kato
Motoki
M
Watabe
Sho
S
Tsuboi
Katsuhiko
K
Ishikawa
Kazuhide
K
Hashiya
Akira
A
Monji
Hideo
H
Utsumi
Shigenobu
S
Kanba
D000328:Adult; D001007:Anxiety / Q000188:drug therapy; D003657:Decision Making / Q000187:drug effects*; D006801:Humans; D008297:Male; D017628:Microglia / Q000187:drug effects* / Q000378:metabolism*; D008911:Minocycline / Q000494:pharmacology* / Q000627:therapeutic use; D010551:Personality / Q000187:drug effects*; D012044:Regression Analysis; D012919:Social Behavior; D035502:Trust; D055815:Young Adult
D008911:Minocycline