Kidney transplantation in a patient with end stage renal disease after complete remission of acute promyelocytic leukemia.
In general, a 2-yr disease-free duration is recommended before kidney transplantation (KT) in end-stage renal disease (ESRD) patients who also have acute leukemia. However, the optimal disease-free interval has not been specified for all subtypes of acute leukemia. Among these subtypes, acute promyelocytic leukemia (APL) shows a favorable prognosis and low relapse rate compared to other types of leukemia. We here report KT after complete remission (CR) of APL in an ESRD patient. Irreversible kidney injury developed in a 23-yr-old man with APL. First, we induced CR and subsequently performed KT 7 months after the achievement of CR. The patient's clinical course after KT was favorable, without allograft rejection or relapse of APL up to 1 yr after KT. On the basis of our clinical experience, it is suggested that a long wait may not be necessary before KT in patients with ESRD and APL.
Transplant Research Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Hyun Ji
HJ
Chun
Su Jeong
SJ
Kim
In O
IO
Sun
Byung Ha
BH
Chung
Ji-Il
JI
Kim
In Sung
IS
Moon
Woo-Sung
WS
Min
Chul Woo
CW
Yang
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000628:therapy*; D016030:Kidney Transplantation; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D010087:Oxides / Q000627:therapeutic use; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism; D012074:Remission Induction; D000072482:Retinoic Acid Receptor alpha; D014463:Ultrasonography
D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; C000607071:RARA protein, human; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D000077237:Arsenic Trioxide