The clinical significance of serum cystatin C in critically ill newborns with normal serum creatinine.
BACKGROUND
The aim of this study is to evaluate the clinical significance of cystatin C(CysC) in the newborns who show normal serum creatinine (Cr) and who are in an intensive care unit.


METHODS
From July 2009 to May 2010, a total of 106 patients (53 male and 53 female newborns) in a neonatal intensive care unit at Kyung Hee Medical Center were enrolled in this study. When clinicians ordered CysC, it was tested using HiSens Cystatin-C LTIA(HBi, An-yang, Korea) on a Toshiba chemical analyzer (Toshiba, Nasushiobara, Japan).


RESULTS
The range of serum Cr and CysCwas from 0.1 to 0.8 mg/dL and from 1.0 to 2.3 mg/L, respectively. CysCpresented the wider amplitude of the changes in acute renal failure.


CONCLUSIONS
In this study, CysCwithout an increased Cr showed only a mild increase. However, CysCreflected more delicate changes in newborns than the serum Cr. This characteristic of CysCcould make it very appropriate for a pediatric population, especially for critically ill newborns.
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, Korea.
Sun Young
SY
Cho
Won-Ho
WH
Hahn
Hee Joo
HJ
Lee
Jin-Tae
JT
Suh
Anbok
A
Lee
Byoung-Soo
BS
Cho
Jin-Soon
JS
Suh
D058186:Acute Kidney Injury / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D012189:Retrospective Studies
D055316:Cystatin C; D002097:C-Reactive Protein; D003404:Creatinine