Highly enantioselective iridium-catalyzed hydrogenation of α,β-unsaturated esters.
α,β-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123, Uppsala, Sweden.
Jia-Qi
JQ
Li
Xu
X
Quan
Pher G
PG
Andersson
D002384:Catalysis; D004952:Esters; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D004952:Esters; D009930:Organic Chemicals; D007495:Iridium