Jiangxienone, a new compound with potent cytotoxicity against tumor cells from traditional Chinese medicinal mushroom Cordyceps jiangxiensis.
A new compound, named jiangxienone, has been isolated from a culture of the traditional Chinese medicinal mushroom Cordyceps jiangxiensis, and its chemical structure was established on the basis of spectroscopic and chemical techniques. Jiangxienone showed potent cytotoxic effects against human gastric adenocarcinoma SGC-7901 cell and human lung carcinoma A549 cell with IC(50) values ranging from 1.38 to 2.93 μM, i.e., with at least approximately six-fold stronger cytotoxicity than cisplatin, a first-line chemotherapy drug for cancer patients.
Division of Applied Mycology and Biochemical Pharmacy, Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical College, Zunyi 563000, PR China. jhxiao@yahoo.cn
Jian-Hui
JH
Xiao
Zhong-Hua
ZH
Sun
Wei-Dong
WD
Pan
Yu-Hong
YH
Lü
Dai-Xiong
DX
Chen
Jian-Jiang
JJ
Zhong
D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D003512:Cyclohexanones / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007189:Indans / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008516:Medicine, Chinese Traditional
D000970:Antineoplastic Agents; D003512:Cyclohexanones; D007189:Indans; C576181:jiangxienone