Relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in pancreatic cancer.
We analyzed relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in exocrine pancreatic cancer (N = 183). Information on laboratory tests and on signs and symptoms was obtained from medical records and patient interviews. Bilirubin, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and alkaline phosphatase were lower in tumor stage IV. The association was due to the relationship between cholestatic syndrome and earlier presentation of patients. There was no association between hepatic biomarkers and stage when adjusting by cholestatic syndrome. Relationships of hepatic and pancreatic biomarkers with pancreatic symptoms and tumor stage must be controlled in "-omics" and other studies using biomarkers.
Hospital del Mar Research Institute - IMIM, Barcelona, Catalonia, Spain. mporta@imim.es
Miquel
M
Porta
José
J
Pumarega
Luisa
L
Guarner
Núria
N
Malats
Ricard
R
Solà
Francisco X
FX
Real
D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001651:Cholestasis, Extrahepatic / Q000097:blood* / Q000209:etiology; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology; D012044:Regression Analysis; D005723:gamma-Glutamyltransferase / Q000097:blood
D014408:Biomarkers, Tumor; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin