Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline infection by Capillaria aerophila.
The nematode Capillaria aerophila (Trichuroidea, Trichuridae) affects the respiratory system of cats and other animals and occasionally of human beings. Infected cats may show bronchovesicular sounds, inflammation, sneezing, wheezing and, chronic cough and, sometimes, bronchopneumonia and respiratory failure. The present study evaluated the efficacy and safety of the antiparasitic spot-on formulation containing imidacloprid 10%/moxidectin 1 % (Advocate®, Bayer Animal Health) in the treatment of natural feline infection with the lungworm C. aerophila. The efficacy of Advocate® administered once was tested on days 7 ± 1 and 11 ± 1 following treatment at day 0 and compared to faecal egg counts on days -6 ± 1 and -2 ± 1. Overall, 36 cats treated either with Advocate® (treatment group, n = 17 cats) or left untreated (control group, n = 19 cats) were included in the study. Geometric means of faecal egg counts values in eggs per gram of faeces were 124.03 prior to treatment and 0.26 posttreatment in treatment group, while 107.03 and 123.94 pre- and posttreatment in the untreated cats. Post-baseline egg counts showed a 99.79 % reduction in Advocate®-treated animals in comparison with cats which were left untreated. Also, treated cats showed no adverse events. This trial demonstrated that Advocate® spot-on formulation is safe and effective in the treatment of feline lung capillariosis caused by C. aerophila.
Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy. dtraversa@unite.it
Donato
D
Traversa
Angela
A
Di Cesare
Emanuela
E
Di Giulio
Giuseppe
G
Castagna
Roland
R
Schaper
Gabriele
G
Braun
Beate
B
Lohr
Fabrizio
F
Pampurini
Piermarino
P
Milillo
Katrin
K
Strube
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects; D002195:Capillaria / Q000187:drug effects / Q000302:isolation & purification; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D004338:Drug Combinations; D017189:Enoplida Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D018942:Macrolides / Q000008:administration & dosage* / Q000009:adverse effects*; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage* / Q000009:adverse effects*; D010270:Parasite Egg Count
D000871:Anthelmintics; D004338:Drug Combinations; D007093:Imidazoles; D018942:Macrolides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; C027837:moxidectin