Cardiac conduction system anomalies and sudden cardiac death: insights from murine models.
The cardiac conduction system (CCS) is composed of a group of myocardial tissues that control and coordinate the heart. Alterations in the CCS - especially in the His-Purkinje system, have been identified as a major cause of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies significantly increase the risk of sudden cardiac death (SCD). SCD is a major contributor to mortality in industrialized countries, and most cases of SCD in the young are related to inherited ion channel diseases. In this paper, we review a series of studies with murine transgenic models that revealed that some arrhythmias are associated with the CCS and may lead to SCD.
Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén Jaén, Spain.
Amelia
A
Aránega
Angel J
AJ
De La Rosa
Diego
D
Franco