Podocyte ACE2 protects against diabetic nephropathy.
As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease angiotensin II levels by generation of angiotensin-(1-7). Nadarajah et al. now show that increased podocyte ACE2 activity can attenuate the development of diabetic nephropathy.
Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. ray.harris@vanderbilt.edu
Raymond C
RC
Harris
D000085962:Angiotensin-Converting Enzyme 2; D000818:Animals; D003928:Diabetic Nephropathies / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism*; D050199:Podocytes / Q000201:enzymology*
D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2