A possible chemopreventive role for photodynamic therapy in Gorlin syndrome: a report of basal cell carcinoma reduction and review of literature.
Multiple basal cell carcinomas (BCC) are a significant cause of morbidity and disfigurement in patients with naevoid basal cell carcinoma syndrome (NBCCS). Chemopreventive strategies are needed to reduce the formation of new BCC in these patients. Appropriate evidence-based guidelines for photodynamic therapy chemoprevention in NBCCS do not exist. We herein report one patient treated with methyl aminolevulinate PDT with red light (630 nm) activation to continue sustained chemoprevention following other BCC chemopreventive modalities and a relevant literature review.
Lake Erie College of Osteopathic Medicine, Lake Erie, Pennsylvania, USA. wolfe1pa@gmail.com
Christopher M
CM
Wolfe
W Harris
WH
Green
Armand B
AB
Cognetta
H Keith
HK
Hatfield
D001478:Basal Cell Nevus Syndrome / Q000473:pathology / Q000517:prevention & control*; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000517:prevention & control*; D005153:Facial Neoplasms / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000473:pathology / Q000517:prevention & control*