Tertiary centres have improved survival compared to other hospitals in the Copenhagen area after out-of-hospital cardiac arrest.
OBJECTIVE
Out-of-hospital cardiac arrest (OHCA) has been reported to carry very varying morbidity and mortality. However, it remains unclear whether this is caused by intrinsic factors of the OHCA or due to the level of in-hospital care. The aim of this study is to compare 30-day and long-term mortality after OHCA at tertiary heart centres and non-tertiary university hospitals.


RESULTS
Data from the Copenhagen OHCA registry from June 2002 through December 2010 included a total of 1218 consecutive patients treated by the same mobile emergency care unit (MECU) with either return of spontaneous circulation (ROSC) or on-going resuscitation (n=53) at hospital arrival. The MECU transported patients to the nearest hospital unless an ECG on scene suggested ST-segment elevation myocardial infarction, in which case patients were transported to the nearest tertiary centre for acute coronary angiography. Therefore, patients with ST-elevation myocardial infarction (n=198) were excluded from the analysis. 30-day mortality was 56% vs. 76% and long term (up to 8years) mortality was 78% vs. 94% for tertiary and non-tertiary hospitals, respectively, both p<0.001. Multivariate analysis showed that admission to a non-tertiary hospital was independently associated with increased risk of death (HR=1.32, 95% CI: 1.09-1.59, p=0.004). Exclusion of patients with on-going resuscitation at admission resulted in HR=1.34 (1.11-1.62), p=0.003. A matched pair propensity score analysis of 255 patients confirmed the results of the proportional hazard analysis (HR=1.35, 95% CI: 1.11-1.65 p=0.003).


CONCLUSIONS
Admission to tertiary centres is associated with lower mortality rates after OHCA compared with non-tertiary hospitals.
Department of Cardiology 2142, The Heart Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. helle.soholm@gmail.com
Helle
H
Søholm
Kristian
K
Wachtell
Søren Loumann
SL
Nielsen
John
J
Bro-Jeppesen
Frants
F
Pedersen
Michael
M
Wanscher
Søren
S
Boesgaard
Jacob Eifer
JE
Møller
Christian
C
Hassager
Jesper
J
Kjaergaard
D000368:Aged; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000401:mortality*; D011446:Prospective Studies; D015996:Survival Rate; D062606:Tertiary Care Centers