Peculiarities of using stem cells for regeneration of the bone and cartilage tissue.
Scientific literature about the use of MSC contains clinical and experimental data on the efficiency of cell technologies for restoration of the osteoarticular apparatus. The use of MSC immobilized in the appropriate carriers and differentiation of these cells towards the bone cells and chondrocytes are of crucial importance. However, the use of MSC, both individual and in combination with other preparations and substances has a number of drawbacks and advantages. The absence of published reports on contraindications and complications of cell therapy is worthy of note, because the analysis of unsuccessful application of MSC will help to determine the indication for this treatment, and hence, to improve the efficiency of cell technologies in the future. Wider use of MSC in clinical practice and experimental studies for acceleration of reparative processes in the bone and cartilage tissue seems to be promising.
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. imai@mail.ru
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Maiborodin
A I
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Shevela
I S
IS
Kolesnikov
M N
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Drovosekov
M S
MS
Toder
A A
AA
Shevela
A I
AI
Brombin
E A
EA
Beregovoy
D000818:Animals; D001861:Bone Regeneration; D002356:Cartilage / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans; D056747:Immunomodulation; D007592:Joint Diseases / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000502:physiology; D013122:Spinal Diseases / Q000628:therapy