β-Endorphin effects on antibody production, proliferation, and secretion of Th1/Th2 cytokines in vivo.
Intraperitoneal injection of β-endorphin in doses of 1, 0.01, and 0.0005 μg/kg under conditions of systemic immunization increased the count of antibody-producing cells in the spleen and the titer of anti-erythrocyte antibodies in the plasma of experimental animals. Intraperitoneal β-endorphin stimulated proliferative activity of splenocytes in mice in the presence of both B- and T-cell mitogen, did not change the production of IFN-γ, reduced the level of IL-2, and stimulated the secretion of IL-4, the main Th2-polarizing factor.
Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences, Perm, Russia. gein@iegm.ru
S V
SV
Gein
T A
TA
Baeva
V O
VO
Nebogatikov
S P
SP
Tendryakova
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D056724:Immunity, Humoral; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000008:administration & dosage*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D018417:Th1 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D058408:Th1-Th2 Balance / Q000187:drug effects*; D018418:Th2 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D001615:beta-Endorphin / Q000008:administration & dosage*
D007376:Interleukin-2; D008070:Lipopolysaccharides; D018377:Neurotransmitter Agents; D003208:Concanavalin A; D015847:Interleukin-4; D001615:beta-Endorphin; D007371:Interferon-gamma