[Conventional basis therapy of rheumatoid arthritis. Effects within and outside cells].
Conventional disease-modifying antirheumatic drugs (DMARDs) were formerly introduced into the treatment of rheumatoid arthritis and other rheumatic disorders on an empirical basis. In many cases their mode of action is only partially understood but as a rule of thumb they act on more than one point within the cellular metabolism. Less often they exert biological effects in the extracellular space or on the cell membrane.
Department für Innere Medizin, Klinik für Innere Medizin II, Universitätsklinikum Halle, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland. gernot.keyszer@uk-halle.de
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D018501:Antirheumatic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism*; D012216:Rheumatic Diseases / Q000188:drug therapy* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
D018501:Antirheumatic Agents