High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2             molecular subtypes and poor prognosis of breast cancer.
The role of Wilms' tumor 1 (WT1) in breast cancer and the relationship between             WT1 expression and clinicopathological factors, molecular subtypes and prognosis             of breast cancer patients have not been clarified to date. We used publicly available             microarray datasets of 266 early breast cancer patients to perform bioinformatics             analysis on the relationship between WT1 mRNA expression and breast cancer. Results             showed that WT1 mRNA expression was correlated with higher histological grades,             ER-negative and basal-like and ERBB2 molecular subtypes in breast cancer. With             regard to disease-free survival analysis, the WT1 high expression group showed             worse prognosis than the low expression group in univariate analysis, and WT1             was demonstrated to be an independent prognostic indicator in multivariate analysis.             This study confirms an oncogenic role of WT1 and demonstrates a possible relation             between WT1 and progression of breast cancer.
Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
Xiao-Wei
XW
Qi
Fan
F
Zhang
Xin-Hua
XH
Yang
Lin-Jun
LJ
Fan
Yi
Y
Zhang
Yan
Y
Liang
Lin
L
Ren
Ling
L
Zhong
Qing-Qiu
QQ
Chen
Kong-Yong
KY
Zhang
Wei-Dong
WD
Zang
Li-Shan
LS
Wang
Ying
Y
Zhang
Jun
J
Jiang
D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D030541:Databases, Genetic; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016162:Genes, Wilms Tumor; D006801:Humans; D015999:Multivariate Analysis; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human