Antifungal activity, toxicity and chemical composition of the essential oil of Coriandrum sativum L. fruits.
The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC₅₀ value of 23 μg/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 μg/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 μg/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.
Postgraduate Program in Veterinary Sciences, State University of Ceará, 60740-000 Fortaleza, CE, Brazil.
Bruna V
BV
Soares
Selene M
SM
Morais
Raquel Oliveira
RO
dos Santos Fontenelle
Vanessa A
VA
Queiroz
Nadja S
NS
Vila-Nova
Christiana M C
CM
Pereira
Edy S
ES
Brito
Manoel A S
MA
Neto
Erika H S
EH
Brito
Carolina S P
CS
Cavalcante
Débora S C M
DS
Castelo-Branco
Marcos F G
MF
Rocha
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D028526:Coriandrum / Q000737:chemistry*; D004058:Diffusion; D005638:Fruit / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D018675:Toxicity Tests
D000935:Antifungal Agents; D009822:Oils, Volatile