Nuclear receptors in regenerating liver and hepatocellular carcinoma.
A comprehensive understanding of the pathways underlying hepatocyte turnover and liver regeneration is essential for the development of innovative and effective therapies in the management of chronic liver disease, and the prevention of hepatocellular carcinoma (HCC) in cirrhosis. Nuclear receptors (NRs) are master transcriptional regulators of liver development, differentiation and function. NRs have been implicated in the modulation of hepatocyte priming and proliferation in regenerating liver, chronic hepatitis and HCC development. In this review, we focus on NRs and their pathways regulating hepatocyte proliferation and liver regeneration, with a perspective view on NRs as candidate biomarkers and novel pharmacological targets in the management of liver disease and HCC.
Laboratory of Lipid Metabolism and Cancer, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.
Michele
M
Vacca
Chiara
C
Degirolamo
Vittoria
V
Massafra
Lorenzo
L
Polimeno
Renato
R
Mariani-Costantini
Giuseppe
G
Palasciano
Antonio
A
Moschetta
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D022781:Hepatocytes / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000502:physiology; D008113:Liver Neoplasms / Q000378:metabolism*; D008115:Liver Regeneration; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015398:Signal Transduction
D001647:Bile Acids and Salts; D008055:Lipids; D018160:Receptors, Cytoplasmic and Nuclear