Cancer and inflammation: an aspirin a day keeps the cancer at bay.
Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany. Maria.Mione@kit.edu
Marina
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Mione
Leonard I
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Zon
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D015027:Zebrafish / Q000235:genetics*
D015232:Dinoprostone