[Dynamics of changes of blood inflammatory-oxidative biomarkers in acute coronary syndrome].
Some inflammatory cytokines and parameters of low density lipoproteins (LDL) oxidative modification were studied in blood of 250 acute coronary syndrome (ACS) patients--Siberian inhabitants, men and women with myocardial infarction (MI) or unstable angina on first, tenth and thirtieth days of disease. The inflammatory biomarkers in men and women with MI are: increased concentrations of interleukin (IL)-6, IL-8 and C-reactive protein (CRP), especially on the first day of disease. The most significant inflammatory biomarker of ACS is increased CRP level, especially in women. Oxidative biomarkers in men with ACS are increased basal level of LDL lipid peroxidation (LPO) products and decreased LDL resistance to oxidation. Inflammatory-oxidative biomarkers IL-6, IL-8, CRP and basal level of LDL LPO products are correlated and independently associated with MI.
Iu I
IuI
Ragino
A D
AD
Kuimov
Ia V
IaV
Polonskaia
E V
EV
Kashtanova
N G
NG
Lozhkina
T A
TA
Balabushevich
N V
NV
Eremenko
U N
UN
Negmadzhonov
D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality; D012307:Risk Factors; D012737:Sex Factors; D012800:Siberia / Q000453:epidemiology; D013997:Time Factors
D015415:Biomarkers; D015850:Interleukin-6; D016209:Interleukin-8; D008077:Lipoproteins, LDL; D002097:C-Reactive Protein