Effects of sodium diclofenac on the concentration function in animals with different neurohypophyseal status.
The characteristics of the osmotic concentration system under conditions of sodium diclofenac treatment were studied in Wistar rats with normally functioning vasopressin gene and homozygotic Brattleboro rats completely lacking endogenous vasopressin. Blockade of prostaglandin synthesis in rats with different neurohypophyseal status stimulated urinary osmolality to a different degree. Different contribution of sodium cations and urea to osmotic concentration was revealed.
Novosibirsk State University, Russia. igor@academ.org
V A
VA
Lavrinenko
A V
AV
Babina
L V
LV
Shestopalova
N F
NF
Beizel
L N
LN
Ivanova
D000818:Animals; D002414:Cations, Monovalent; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D009994:Osmolar Concentration; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D011448:Prostaglandin Antagonists / Q000008:administration & dosage*; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D011910:Rats, Brattleboro; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine; D014508:Urea / Q000652:urine; D014667:Vasopressins / Q000172:deficiency / Q000235:genetics; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002414:Cations, Monovalent; D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D014667:Vasopressins; D004008:Diclofenac; D014508:Urea; D012964:Sodium