Effects of Prolyl-Glycyl-Proline (PGP) peptide on disorders in rat mesenteric lymphatic vessel function induced by injection of substance 48/80.
Injection of substance 48/80 to rats led to dysfunction of mesenteric lymphatic microvessels, in particular inhibition of their contractility and modification of their reaction to norepinephrine. Injection of PGP peptide before and after substance 48/80 alleviated these disorders. The results indicated the possibility of peptide correction of lymphatic vessel dysfunction.
Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Russia. bellaum@mail.ru
B A
BA
Umarova
N S
NS
Bondarenko
T V
TV
Lelekova
G N
GN
Kopylova
G E
GE
Samonina
D000818:Animals; D007273:Injections, Intramuscular; D042601:Lymphatic Vessels / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008643:Mesentery / Q000187:drug effects; D009638:Norepinephrine / Q000008:administration & dosage*; D009842:Oligopeptides / Q000627:therapeutic use*; D011392:Proline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage* / Q000031:analogs & derivatives*
D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D003189:p-Methoxy-N-methylphenethylamine; D011392:Proline; D009638:Norepinephrine