Effect of CPP-ACP paste on dental caries in primary teeth: a randomized trial.
This clinical trial tested the effect of daily application of 10% w/v calcium phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste for 1 yr when added to regular toothbrushing with fluoridated toothpaste to prevent dental caries in pre-school children. High-caries-risk children aged 2½ to 3½ yrs in a suburban area of central Thailand were assigned to receive either CPP-ACP (n = 150) or a placebo control (n = 146) in addition to fluoridated toothpaste. The International Caries Detection and Assessment System (ICDAS) was recorded at baseline, 6 mos, and 1 yr. At 1 yr, a significant increase in mean numbers of enamel and dentin caries lesions, as well as dmfs, was found in both groups (p < 0.001). No significant difference was observed between groups on these 3 outcome measures (p = 0.23, 0.84, and 0.91, respectively). The odds of enamel caries lesion transitions to a state of regression or stability, compared with progression from baseline, was also not different between groups [OR = 1.00, 95% CI (0.86, 1.17)]. This trial found that daily application of 10% w/v CPP-ACP paste on school days for 1 yr, when added to regular toothbrushing with a fluoride toothpaste, had no significant added effect in preventing caries in the primary dentition of these pre-school children (ClinicalTrials.gov number CT01 604109).
Faculty of Dentistry, Thammasat University, Rangsit Campus, Patumthani, Thailand.
T
T
Sitthisettapong
P
P
Phantumvanit
C
C
Huebner
T
T
Derouen
D002327:Cariostatic Agents / Q000627:therapeutic use*; D002364:Caseins / Q000627:therapeutic use*; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D003743:Dental Enamel / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D016015:Logistic Models; D008297:Male; D013785:Thailand; D014094:Tooth, Deciduous
D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides