Smart self-assembled hybrid hydrogel biomaterials.
Hybrid biomaterials are systems created from components of at least two distinct classes of molecules, for example, synthetic macromolecules and proteins or peptide domains. The synergistic combination of two types of structures may produce new materials that possess unprecedented levels of structural organization and novel properties. This Review focuses on biorecognition-driven self-assembly of hybrid macromolecules into functional hydrogel biomaterials. First, basic rules that govern the secondary structure of peptides are discussed, and then approaches to the specific design of hybrid systems with tailor-made properties are evaluated, followed by a discussion on the similarity of design principles of biomaterials and macromolecular therapeutics. Finally, the future of the field is briefly outlined.
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA. jindrich.kopecek@utah.edu
Jindřich
J
Kopeček
Jiyuan
J
Yang
D000595:Amino Acid Sequence; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D015374:Biosensing Techniques / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods; D005818:Genetic Engineering / Q000379:methods; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D008958:Models, Molecular; D008969:Molecular Sequence Data; D050997:Nanomedicine; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use
D001672:Biocompatible Materials; D010455:Peptides; D011506:Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate