[ICAM-1 469K/E gene polymorphisms increase the risk of gastric dysplasia].
OBJECTIVE
To investigate the influence of ICAM-1 469K/E gene polymorphisms on the risk of atrophic gastritis and dysplasia.


METHODS
The ICAM-1 469K/E gene polymorphisms in a total of 372 subjects were detected by polymerase chain reaction-direct sequencing. All of the subjects were from Linqu County, a high risk area of gastric cancer in Shandong Province of northern China. All cases were initially diagnosed as normal or superficial gastritis at the beginning of this study. After a 5-year follow-up, the cases were subdivided into no progression group (no histological progression, n=137), progression group I (progressed to severe chronic atrophic gastritis, n=194) and progression group II (progressed to low-grade dysplasia, n=41).


RESULTS
In all 372 subjects, the frequencies of KK, KE or EE genotype of ICAM-1 K469E were 50.5%, 39.2% and 10.2%, respectively. No significant differences were observed in the ICAM-1 469K/E genotype frequencies between the progression group I and no progression group (P>0.05). The frequencies of KK genotype (68.3%) were significantly higher in the progression group II than in the no progression group (49.6%, P=0.035), and also than in the progression group I (47.4%, P=0.015). An increased risk of the progressing to dysplasia from normal or superficial gastritis was found in the individuals with ICAM-1 469KK genotype [odds ratio (OR)=2.21, 95%CI, 1.10-4.42].


CONCLUSIONS
ICAM-1 469K/E gene polymorphisms are significantly associated with the risk of gastric low-grade dysplasia, but not related with severe chronic atrophic gastritis in a population with high risk of gastric cancer in Linqu County, Shandong Province, China.
Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China.
Zhong-wu
ZW
Li
Meng-meng
MM
Tian
Ying
Y
Wu
Yu
Y
Sun
Guo-shuang
GS
Feng
Wei-cheng
WC
You
Ji-you
JY
Li
Ai-lian
AL
Zhao
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005756:Gastritis / Q000235:genetics / Q000473:pathology; D005757:Gastritis, Atrophic / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D018799:Intercellular Adhesion Molecule-1