Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation.
Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Su-Youne
SY
Chang
Inyong
I
Kim
Michael P
MP
Marsh
Dong Pyo
DP
Jang
Sun-Chul
SC
Hwang
Jamie J
JJ
Van Gompel
Stephan J
SJ
Goerss
Christopher J
CJ
Kimble
Kevin E
KE
Bennet
Paul A
PA
Garris
Charles D
CD
Blaha
Kendall H
KH
Lee
D000241:Adenosine / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D046690:Deep Brain Stimulation; D055664:Electrochemical Techniques; D004563:Electrochemistry; D020329:Essential Tremor / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D059015:Wireless Technology
D000241:Adenosine