Evaluation of periimplant crevicular fluid prostaglandin E2 and matrix metalloproteinase-8 levels from health to periimplant disease status: a prospective study.
OBJECTIVE
To compare the levels of prostaglandin E2 (PGE2) and matrix metalloproteinases-8 (MMP-8) in periimplant crevicular fluid (PICF) after osseointegration and loading.


METHODS
PICF was collected at the 3rd, 6th, 12th, and 18th months after implantation of 72 implants. PGE2 and MMP-8 levels besides clinical parameters were evaluated.


RESULTS
Plaque and gingival index at the 6th, 12th, and 18th months presented higher values. Probing depth showed an increase after the 12th month. PGE2 presented a higher value at the 18th month. MMP-8 level demonstrated higher values after the sixth month. PGE2 and MMP-8 demonstrated positive correlations with gingival index and probing depth.


CONCLUSIONS
The detection of PGE2 and MMP-8 in PICF serve to be useful for monitoring the course of periimplant disease. MMP-8 promises to be an early signal of periimplant inflammation.
Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Turkey. cansu.basegmez@gmail.com
Cansu
C
Basegmez
Serdar
S
Yalcin
Funda
F
Yalcin
Selim
S
Ersanli
Eitan
E
Mijiritsky
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015921:Dental Implants; D003774:Dental Plaque Index; D019094:Dental Prosthesis, Implant-Supported; D015232:Dinoprostone / Q000032:analysis*; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology; D006801:Humans; D020784:Matrix Metalloproteinase 8 / Q000032:analysis*; D016348:Osseointegration / Q000502:physiology; D057873:Peri-Implantitis / Q000201:enzymology / Q000378:metabolism*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000201:enzymology / Q000378:metabolism; D011446:Prospective Studies; D013280:Stomatitis / Q000201:enzymology / Q000378:metabolism
D015415:Biomarkers; D015921:Dental Implants; C488762:MMP8 protein, human; D020784:Matrix Metalloproteinase 8; D015232:Dinoprostone