Effect of erythropoietin on activity of plasma proteolytic systems during experimental renal failure.
Activity of plasma proteolytic systems (fibrin formation, fibrinolysis, and anticoagulant system) and the possibility for correction of changes in these systems with erythropoietin were studied in experiments on outbred albino rats with experimental renal failure. Renal failure was induced by a single subcutaneous injection of mercury chloride (II). The parameters were estimated on day 5 postinjection. Erythropoietin in a single dose of 5000 U/kg was administered on day 4. Renal failure was accompanied by activation of fibrin formation (with factors of the common and intrinsic pathways of blood coagulation), increase in antithrombin activity, and inhibition of the fibrinolytic system. Treatment with erythropoietin led to partial recovery of fibrin formation and fibrinolysis. Under analytical in vitro conditions, 30-min incubation of whole blood from healthy donors with erythropoietin in doses of 1.9-30.0 U/liter was followed by a dose-dependent inhibition of the fibrin formation system and activation of fibrinolysis.
Department of Pathophysiology, Chelyabinsk State Medical Academy, Ministry of Health and Social Development of Russian Federation, Chelyabinsk, Russia. mvo2003@list.ru
M V
MV
Osikov
T A
TA
Grigoriev
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology* / Q000627:therapeutic use*; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D011897:Random Allocation; D051381:Rats; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000378:metabolism
D004921:Erythropoietin; D005337:Fibrin