Systems biology of skeletal muscle: fiber type as an organizing principle.
Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca(2+) from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross-bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction.
Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Sarah M
SM
Greising
Heather M
HM
Gransee
Carlos B
CB
Mantilla
Gary C
GC
Sieck
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000737:chemistry / Q000378:metabolism; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D049490:Systems Biology
D009124:Muscle Proteins; D002118:Calcium