Association study of APC polymorphisms with colorectal cancer in Han Chinese.
OBJECTIVE
Colorectal cancer (CRC) is a common malignancy with worldwide prevalence. Familial adenomatous polyposis (FAP), a predisposition syndrome of CRC, is caused by germ line mutations in the APC gene. Mutations in APC are thought to be an early event in colorectal tumorigenesis. We hypothesized that common variants in APC might be associated with CRC.


METHODS
A case-control study genotyping ten SNPs was conducted in 312 CRC patients and 270 normal controls in the Chinese Han population.


RESULTS
The genotype frequency of rs2019720 showed a significant difference between cases and controls (p=0.046, after Bonferroni correction). For the three pairs of SNPs in strong LD, we carried out haplotype analyses but no significant association was detected.


CONCLUSIONS
Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.
Xiaoye
X
Huang
Yang
Y
Wang
Tao
T
Yu
Baocheng
B
Liu
Xin
X
Li
Weidong
W
Li
Shiqing
S
Chen
Qingzhu
Q
Zhao
Xingwang
X
Li
Fengping
F
Yang
Quan
Q
Wang
Jinfen
J
Wang
Yanzeng
Y
Xiao
Yifeng
Y
Xu
Guoyin
G
Feng
Zhihai
Z
Peng
Lin
L
He
Guang
G
He
D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C555337:APC protein, human; D025601:Adenomatous Polyposis Coli Protein