Pilot randomized trials: is there a need?
A pilot randomized study is often essential to ensure the feasibility of conducting a large, randomized study. Pilot studies help to define the sample size, establish measurable outcomes, promote methodological rigor, establish the ability to recruit participants, assess the risk-benefit ratio of the treatments, and evaluate the economic viability of a definitive study.
Department of Orthopaedic Surgery, Greenville Hospital System University Medical Center, 701 Grove Road, Greenville, SC 29605, USA. kjeray@ghs.org
Kyle J
KJ
Jeray
Stephanie L
SL
Tanner
D003625:Data Collection; D005240:Feasibility Studies; D006801:Humans; D019637:Orthopedic Procedures; D018579:Patient Selection; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D012109:Research Support as Topic; D012308:Risk Management