Passive and active target delivery of drugs to ischemic myocardium.
Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.
V. A. Almazov Center of Heart, Blood, and Endocrinology, St. Petersburg, Russia. galagoudza@mail.ru
M M
MM
Galagudza
D V
DV
Korolev
D L
DL
Sonin
I V
IV
Alexandrov
S M
SM
Minasian
V N
VN
Postnov
E B
EB
Kirpicheva
G V
GV
Papayan
I S
IS
Uskov
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004337:Drug Carriers / Q000493:pharmacokinetics* / Q000633:toxicity; D019793:Fluorescein / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D006339:Heart Rate / Q000187:drug effects; D008422:Materials Testing; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D053758:Nanoparticles; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000493:pharmacokinetics* / Q000633:toxicity; D014018:Tissue Distribution
D004337:Drug Carriers; D005456:Fluorescent Dyes; D012822:Silicon Dioxide; D019793:Fluorescein