Radiation therapy for cutaneous melanoma.
Radiation therapy is used infrequently for cutaneous melanoma, despite research suggesting benefit in certain clinical scenarios. This review presents data forming the highest level of evidence supporting the use of radiation therapy. Retrospective and prospective studies demonstrate radiation therapy for primary tumors is associated with high control rates. Two randomized trials have found improvements in regional control with adjuvant radiotherapy to regional lymphatics. Retrospective and prospective studies demonstrate radiation therapy is associated with palliative response and metastatic tumor control. Optimal care of melanoma patients involves radiation therapy; awareness of this is incumbent of clinicians caring for patients with this disease.
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. barkerc@mskcc.org
Christopher A
CA
Barker
Nancy Y
NY
Lee
D019317:Evidence-Based Medicine; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000532:radiotherapy*; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery