Copper(II)-mediated dehydrogenative cross-coupling of heteroarenes.
Cu(OAc)(2)-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Zhifeng
Z
Mao
Zhe
Z
Wang
Zhaoqing
Z
Xu
Fei
F
Huang
Zhengkun
Z
Yu
Rui
R
Wang
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D006571:Heterocyclic Compounds; D003300:Copper