A modular synthesis of dithiocarbamate pendant unnatural α-amino acids.
Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.
Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, Cincinnati, Ohio 45268, USA.
Amit
A
Saha
R B Nasir
RB
Baig
John
J
Leazer
Rajender S
RS
Varma
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000737:chemistry; D013859:Thiocarbamates / Q000737:chemistry*
D000596:Amino Acids; D000838:Anions; D013451:Sulfonic Acids; D013859:Thiocarbamates; C005741:sulfamic acid