[Acquired factor V inhibitor: 3 cases report and literature review].
OBJECTIVE
To better understand the acquired factor V (FV) inhibitors.


METHODS
The clinical features, laboratory manifestations, treatment options and prognosis of 3 cases were reported and related literature were reviewed.


RESULTS
All the 3 patients were older than 50 years without family history and related disease. Their clinical manifestations included spontaneously mucous bleeding, hematuria, epistaxis and encephalic bleeding. Laboratory test showed prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT). The FV levels decreased and the presence of FV inhibitor was confirmed by Bethesda method. All patients were treated with glucocorticoid and immunosuppressive agents. The haemorrhages of two patients stopped but their coagulation test and FV level recovered slowly. One patient died from encephalic bleeding.


CONCLUSIONS
Acquired FV inhibitor is a rare coagulation disorder with variable clinical symptoms. Immunosuppressive agents are effective to eliminate the inhibitors. The prognosis of acquired FV inhibitors seemed to be strictly related to the basic disease.
Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin, China.
Yan-hui
YH
Yang
Hong-mei
HM
Wang
Feng
F
Xue
Xiao-fan
XF
Liu
Yong-ze
YZ
Liu
Lei
L
Zhang
Ren-chi
RC
Yang
D020147:Coagulation Protein Disorders; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D005165:Factor V