Effect of combination therapy with coenzyme Q10 on functional and metabolic parameters in patients with type 1 diabetes mellitus.
Functional state of the kidneys, severity of metabolic disturbances, intensity of LPO, and activity of the antioxidant system in 30 patients (18-36 years old) with type 1 diabetes mellitus and diabetic nephropathy of different compensation were studied before and after standard therapy or combination treatment with coenzyme Q10. Similar parameters were evaluated in 20 healthy subjects of the same age group. The development of metabolic disturbances in patients with type 1 diabetes mellitus (decompensated form) was accompanied by activation of LPO and inhibition of the antioxidant system. These patients were characterized by oxidative stress, diabetic nephropathy with associated proteinuria, and impairment of water excretion, electrolyte excretion, and nitrogen excretion in the kidneys. Combination therapy with coenzyme Q10 had a positive effect on LPO and antioxidant system. This treatment was followed by the relief of hyperglycemia, decrease in the concentrations of glycosylated hemoglobin and LDL cholesterol, and improvement of nitrogen metabolism.
Institute of Biomedical Studies, Vladikavkaz Research Center, Russian Academy of Sciences and Government of the Republic of North OssetiaAlania, Russia. fira-beliko-va@mail.ru
S G
SG
Dzugkoev
M B
MB
Kaloeva
F S
FS
Dzugkoeva
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000379:methods*; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D011507:Proteinuria / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000975:Antioxidants; D008078:Cholesterol, LDL; D004573:Electrolytes; D006454:Hemoglobins; D014451:Ubiquinone; C024989:coenzyme Q10; D009584:Nitrogen