Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.
Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin-8-carbaldehydes are lacking. We describe here a high-yielding continuous flow synthesis that requires no manual intermediate purification or work-up, giving access to multigram quantities of the aldehyde product.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Jaroslav
J
Zak
David
D
Ron
Elena
E
Riva
Heather P
HP
Harding
Benedict C S
BC
Cross
Ian R
IR
Baxendale
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*
D000447:Aldehydes; D003374:Coumarins; D005456:Fluorescent Dyes