Severe pazopanib-induced hepatotoxicity: clinical and histologic course in two patients.
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Samuel J
SJ
Klempner
Toni K
TK
Choueiri
Eric
E
Yee
Leona A
LA
Doyle
Detlef
D
Schuppan
Michael B
MB
Atkins
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007191:Indazoles; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*; D013449:Sulfonamides / Q000009:adverse effects*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
D007191:Indazoles; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A; C516667:pazopanib