A review of update clinical results of carbon ion radiotherapy.
Among various types of ion species, carbon ions are considered to have the most balanced, optimal properties in terms of possessing physically and biologically effective dose localization in the body. This is due to the fact that when compared with photon beams, carbon ion beams offer improved dose distribution, leading to the concentration of the sufficient dose within a target volume while minimizing the dose in the surrounding normal tissues. In addition, carbon ions, being heavier than protons, provide a higher biological effectiveness, which increases with depth, reaching the maximum at the end of the beam's range. This is practically an ideal property from the standpoint of cancer radiotherapy. Clinical studies have been carried out in the world to confirm the efficacy of carbon ions against a variety of tumors as well as to develop effective techniques for delivering an efficient dose to the tumor. Through clinical experiences of carbon ion radiotherapy at the National Institute of Radiological Sciences and Gesellschaft für Schwerionenforschung, a significant reduction in the overall treatment time with acceptable toxicities has been obtained in almost all types of tumors. This means that carbon ion radiotherapy has meanwhile achieved for itself a solid place in general practice. This review describes clinical results of carbon ion radiotherapy together with physical, biological and technological aspects of carbon ions.
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. tsujii@nirs.go.jp
Hirohiko
H
Tsujii
Tadashi
T
Kamada
D002244:Carbon / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007477:Ions; D018499:Linear Energy Transfer; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D012062:Relative Biological Effectiveness; D016896:Treatment Outcome
D007477:Ions; D002244:Carbon