The yin-yang nature of CSF1R-binding cytokines.
Most myeloid cells express the growth-factor receptor CSF1R. Recognition of interleukin 34 by CSF1R is required for the development of tissue-resident Langerhans cells and microglia, which explains the independence of their growth from CSF1.
Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore.
Teresa
T
Zelante
Paola
P
Ricciardi-Castagnoli
D000818:Animals; D007378:Interleukins / Q000378:metabolism*; D007801:Langerhans Cells / Q000502:physiology*; D017628:Microglia / Q000502:physiology*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D014901:West Nile Fever / Q000276:immunology*
D007378:Interleukins; C552364:interleukin-34, mouse; D016186:Receptor, Macrophage Colony-Stimulating Factor