[Safety of Magnesium sulfate in severe preeclampsia].
BACKGROUND
Several observational studies and randomized trials have described the use of various regimens of magnesium sulfate to prevent or reduce the rate of seizures and complications in women with severe preeclampsia.


OBJECTIVE
To assess the validity of a service protocol in the management of severe pre-eclampsia all specifying the benefits, complications and side effects of magnesium sulfate .


METHODS
We have performed a retrospective descriptive study over two years (2009-2010) concerning 150 patients affected with severe preeclampsia in the department "B" of gynecology and obstetrics of the "Rabta" at the Centre of Maternity and Neonatology of Tunis (third level maternity). The protocol consisted in the administration of 3 grammes of magnesium sulfate followed by intravenous dose of 1 g/hour associated with an anti-hypertensive treatment.


RESULTS
One hundred and forty patients (93%) had 2 or more criteria of severity associated. Seventy-eight (52 %) patients with severe preeclampsia have profited an anti-hypertensive treatment based on nicardipine associated with magnesium sulfate without notable secondary effects. In two cases (1.3 %) an eclampsia was noted with magnesium sulfate, 27.4 % of severe preeclampsia was noted at a term within 34 week of amenorrhea. Only one case of surdosage was noted in post partum.


CONCLUSIONS
The use of magnesium sulfate in practice does not appear to increase the risk of complications or major side effects in the mother and fetus.
Universite de Tunis, El Manar, Tunisie.
Monia
M
Malek-Mellouli
Youssef
Y
Atef
Fethi
F
Ben Amara
Maher
M
Nasr
Neji
N
Khaled
Mourad
M
Bouchnack
Hayen
H
Maghrebi
Hedi
H
Reziga
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
D008278:Magnesium Sulfate