Involvement of P2Y receptors in myocardial contractile activity of rats during postnatal ontogeny.
We studied the effect of uridine 5'-triphosphate in concentrations of 10(-10)-10(-6) M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5'-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21- and 100-day-old rat pups, exogenous uridine 5'-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditions of P2Y(4) purinoceptor blockade with reagent blue-2. These data indicate that the effect of UTP on the myocardium is realized via P2Y(4) purinoceptors.
Department of Human Anatomy and Physiology, Tatar State HumanitarianandTraining University, Kazan, Russia. tania57vg1@rambler.ru
T A
TA
Anikina
I N
IN
Anisimova
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FG
Sitdikov
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007537:Isometric Contraction / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D046509:Tissue Culture Techniques; D014227:Triazines / Q000494:pharmacology; D014544:Uridine Triphosphate / Q000494:pharmacology*
D058921:Purinergic P2Y Receptor Antagonists; D018048:Receptors, Purinergic P2; D014227:Triazines; C104749:purinoceptor P2Y4; C012842:Cibacron Blue F 3GA; D014544:Uridine Triphosphate