Reduced glutathione-resisting ¹⁹F NMR sensors for detecting HNO.
The (19)F NMR probes for the HNO detection are reported. We synthesized the probe molecules with the paramagnetic Cu(II) complex and fluorine atoms using a cubic silsesquioxane. By using the magnetism changes of the Cu(II) to Cu(I) in the complex by the reduction with HNO, the (19)F NMR signal intensities of the probe increased. Noteworthily, our probes have superior resistance to reduced glutathione which is the major intracellular molecule to maintain the reductive environment and the competitor in the reduction of Cu(II) against HNO.
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Narufumi
N
Kitamura
Tatsuhiro
T
Hiraoka
Kazuo
K
Tanaka
Yoshiki
Y
Chujo
D003300:Copper / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009589:Nitrogen Oxides / Q000032:analysis*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
D009589:Nitrogen Oxides; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D005461:Fluorine; D003300:Copper; D005978:Glutathione; C039900:nitroxyl