Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles.
Pd/C in HFIP was used to hydrogenate indole derivatives under relatively mild conditions, leading to potential synthetic intermediates of bioactive compounds. Depending on their substitution, tetrahydroindoles or octahydroindoles could selectively be obtained.
Université de Lyon, Université Lyon 1, ICBMS, équipe SURCOOF, CNRS, UMR 5246, Bât. Raulin, 43 Bd du 11 Nov. 1918, 69622 Villeurbanne cedex, France.
Damien
D
Clarisse
Bernard
B
Fenet
Fabienne
F
Fache