Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi.
Two new iridoids, jatadoids A (1) and B (2), and two known compounds (3 and 4) were isolated from Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Compound 1 possessed an isovaleroxy group at the C-3 position that has previously been unreported in the class of iridoids. Four compounds were evaluated and compounds 1 and 3 showed moderate neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
Jing
J
Xu
Yushan
Y
Li
Yuanqiang
Y
Guo
Ping
P
Guo
Tohru
T
Yamakuni
Yasushi
Y
Ohizumi
D015655:1-Methyl-4-phenylpyridinium / Q000037:antagonists & inhibitors / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006540:Herbicides / Q000037:antagonists & inhibitors / Q000633:toxicity; D006801:Humans; D039823:Iridoids / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014632:Valerian / Q000737:chemistry*
D006540:Herbicides; D039823:Iridoids; D018696:Neuroprotective Agents; C576383:jatadoid A; D015655:1-Methyl-4-phenylpyridinium