Antioxidant composition causes antiexsudorific effect in the model of chronic venous insufficiency.
Venous hypertension and swelling of the hind limbs was demonstrated to develop in rat model of chronic venous insufficiency. It was found that 14-day course of dihydroquercetin (50 mg/kg) and lipoic acid (50 mg/kg) administered intragastrically prevented the increase in hind limb volume and reduced the severity of edema of rat muscle tissue in chronic venous insufficiency.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
I S
IS
Ivanov
A V
AV
Sidekhmenova
O I
OI
Aliev
T I
TI
Fomina
L A
LA
Ermolaeva
N A
NA
Tyukavkin
M B
MB
Plotnikov
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002908:Chronic Disease; D004487:Edema / Q000209:etiology / Q000517:prevention & control; D006614:Hindlimb / Q000098:blood supply / Q000473:pathology; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D008063:Thioctic Acid / Q000494:pharmacology*; D014689:Venous Insufficiency / Q000150:complications / Q000188:drug therapy*
D000975:Antioxidants; D008063:Thioctic Acid; D011794:Quercetin; C003377:taxifolin