Biliary atresia and cytomegalovirus and  response to valganciclovir.
Biliary atresia has been commonly reported with cytomegalovirus (CMV) infection. CMV positive patients may present with a later onset however long term outcome is similar to non-CMV patients. There are very few case reports of role of antivirals in CMV and biliary atresia. We treated a 2 month old girl with biliary atresia who underwent portoduodenostomy at 2 and half months of age but continued to have jaundice (bilirubin = 23.6 mg/dl) even after 1 month of Kasai's surgery and subsequently was treated with valganciclovir for 6 weeks following which her jaundice resolved.
Department of Pediatric Hepatobiliary Clinic, BJ Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India. irashah@pediatriconcall.com
Ira
I
Shah
Sushmita
S
Bhatnagar
D000998:Antiviral Agents / Q000627:therapeutic use*; D001656:Biliary Atresia / Q000188:drug therapy* / Q000821:virology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D000077562:Valganciclovir
D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir