Association of circulating endothelial progenitor cells (CD14+-EPC) with renal function in patients with coronary artery disease.
BACKGROUND
The relationships between the endothelial progenitor cells (EPCs)-CD34(+) and CD14(+) and coronary artery disease (CAD) were reported and the association of CD34(+) cells with renal function was studied previously. Another kind EPC-CD14(+) cell and its association with renal function in patients with CAD have not been reported yet. Our aim was to assess CD14(+) cell counts versus renal function in CAD.


RESULTS
We studied 242 patients with severe angiographic CAD and 30 healthy control participants. The CD14(+) cells were enumerated by flow cytometry. With lowering glomerular filtration rate (GFR), CD14(+) cell numbers (percentage of lymphocytes, median and interquartile range) decreased: 0.04 (0.03-0.06), 0.03 (0.02-0.05), 0.02 (0.01-0.03) for estimated glomerular filtration rate (eGFR) ≥90, 60 to 89, and 30 to 89 mL/min per 1.73 m(2), respectively (P < .001 for trend). The CD14(+) cell counts correlated with eGFR (r = .27, P = .03). By multivariate liner regression analysis, the difference remains significant (P = .02).


CONCLUSIONS
The CD14(+) cell depletion is associated with renal dysfunction in CAD.
1The 2nd affiliated Hospital of Chongqing Medical University, Chongqing, China.
Gui-Qiong
GQ
Li
Yan
Y
Yang
Da-Zhi
DZ
Ke
Xing-Sheng
XS
Li
Qing
Q
Wu
Guang-Yu
GY
Cao
Qing-Wei
QW
Chen
D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000473:pathology; D012307:Risk Factors; D013234:Stem Cells / Q000378:metabolism*
D018950:Lipopolysaccharide Receptors