Effect of dehydroepiandrosterone sulfate on aldosterone level during stress exposures: role of μ-opioid receptors.
Dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg) blocks stress-induced elevation of aldosterone concentration in rats subjected to repeated stress. Administration of DHEAS together with opioid receptor antagonist naltrexone in a dose of 0.1 mg/kg, i.e. the dose that selectively blocks μ-opioid receptors, abolished this blocking effect of DHEAS, which suggests that it is mediated by μ-opioid receptors. Under conditions of cold exposure, DHEAS exhibits the aldosterone-blocking effect even after single presentation of the stress factor. However, this effect is realized not via μ-opioid receptors, which attests to differences in the regulatory mechanisms depending on the nature of the external factor.
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. T.A.Obut@physiol.ru
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D000450:Aldosterone / Q000096:biosynthesis / Q000097:blood*; D000818:Animals; D003080:Cold Temperature; D003687:Dehydroepiandrosterone / Q000008:administration & dosage*; D004336:Drug Antagonism; D005260:Female; D007279:Injections, Subcutaneous; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage*; D009271:Naltrexone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects*
D000451:Mineralocorticoid Receptor Antagonists; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D003687:Dehydroepiandrosterone; D000450:Aldosterone; D009271:Naltrexone