Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography.
The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.
Department of NanoEngineering, University of California, San Diego, CA 92093, USA. zhangap@zju.edu.cn
A Ping
AP
Zhang
Xin
X
Qu
Pranav
P
Soman
Kolin C
KC
Hribar
Jin W
JW
Lee
Shaochen
S
Chen
Sailing
S
He
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D005109:Extracellular Matrix / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D036103:Nanotechnology; D013499:Surface Properties; D023822:Tissue Engineering; D014466:Ultraviolet Rays
D001672:Biocompatible Materials