Adaptation of dynamic covalent systems of imine constituents to medium change by component redistribution under reversible phase separation.
A dynamic covalent library of interconverting imine constituents, dissolved in an acetonitrile/water mixture, undergoes constitutional reorganization upon phase separation induced by a physical stimulus (heat) or a chemical effector (inorganic salt, carbohydrate, organic solvent). The process has been made reversible, regenerating the initial library upon phase reunification. It represents the behavior of a dynamic covalent library upon reversible phase separation and its adaptation to a phase change, with up-regulation in each phase of the fittest constituents by component selection. Finally, the system exemplifies the splitting of a 2D (square) constitutional dynamic network into a 3D (cube) one.
Institut de Science et d'Ingénierie Supramoléculaires, ISIS Université de Strasbourg, Strasbourg 67000, France.
Nema
N
Hafezi
Jean-Marie
JM
Lehn