[Flocculation process of aqueous extracts of zhisou dingchuan oral solution with quaternary ammonium salt of chitosan].
OBJECTIVE
To study the effect of quaternary ammonium salt of chitosan (HACC) in purifying aqueous extracts of Zhisou Dingchuan oral solution.


METHODS
Modified quaternary ammonium salt of chitosan was used to flocculate aqueous extracts of Zhisou dingchuan oral solution, with turbidity degree and the retention rate of ephedrine and glycyrrhizin as indicators, to detect the influences of flocculant dosage, suspension temperature, mixing speed and time on flocculation effect. The optimum process conditions were found through orthogonal experimental design.


RESULTS
The optimum process conditions: the flocculation temperature 30 degrees C, HACC's dosage 0.4 g x L(-1), the fast mixing speed 500 r x min(-1) and its time 1 min, the slow mixing speed 50 r x min(-1) and it time 2.4 10 min. Under the conditions, the retention rate of ephedrine was 97.6%, the turbidity degree was 1.1 NTU and 2.8 NTU after 30 days.


CONCLUSIONS
HACC can be used to purify aqueous extracts of Zhisou Dingchuan oral solution.
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zezhan
Z
Sun
Jiao
J
Sun
Li
L
Qin
Yong
Y
Kang
D048271:Chitosan / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005427:Flocculation; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D048271:Chitosan