Palladium(0)-catalyzed dearomative arylation of indoles: convenient access to spiroindolenine derivatives.
Dearomatization of an indole via palladium(0)-catalyzed cross-coupling reaction has been realized. With readily available triphenylphosphine as ligand, various spiroindolenine derivatives have been obtained in good to excellent yields, and enantioselective control is also feasible with chiral ligands.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
Ke-Jia
KJ
Wu
Li-Xin
LX
Dai
Shu-Li
SL
You
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D007211:Indoles; D008024:Ligands; D013141:Spiro Compounds; D010165:Palladium