Computer modeling of transketolase-like protein, TKTL1, a marker of certain tumor tissues.
A computer model of the spatial structure of transketolase-like protein (TKTL1), a marker of certain tumor tissues, has been constructed using the known spatial structure of transketolase found in normal human tissues. The structure of the two proteins at all levels of their organization has also been compared. On the basis of the revealed differences in structures of these proteins, we assume it is unlikely that TKTL1 can be a thiamine diphosphate-dependent protein capable of catalyzing the transketolase reaction.
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia.
A O
AO
Maslova
L E
LE
Meshalkina
G A
GA
Kochetov
D014408:Biomarkers, Tumor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000201:enzymology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D014174:Transketolase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D029701:Saccharomyces cerevisiae Proteins; C505431:TKTL1 protein, human; D014174:Transketolase; D013835:Thiamine Pyrophosphate