Changes in the levels of inhibitory and excitatory amino acids in the brain structures of female rats with cobalt epileptogenic focus during different phases of the estrous cycle.
We studied changes in the levels of inhibitory and excitatory neurotransmitters in female rat brain structures during different phases of the estrous cycle in health and after creation of a cobalt epileptogenic focus at stage I of epileptogenic system development. The most pronounced shifts were found in the contralateral cortex, where the levels of GABA and glycine decreased significantly during the diestrus-2 phase (corresponding to menstruation), which attests to a convulsive threshold decrease during this period.
N. I. Pirogov Russian State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia. letam@bk.ru
Yu B
YB
Filatova
T A
TA
Voronina
P M
PM
Klodt
V S
VS
Kudrin
L N
LN
Nerobkova
F K
FK
Rider
G N
GN
Avakyan
D000818:Animals; D021461:Animals, Outbred Strains; D001224:Aspartic Acid / Q000378:metabolism*; D003035:Cobalt; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D030762:Estrous Cycle / Q000378:metabolism*; D018846:Excitatory Amino Acids / Q000378:metabolism; D005260:Female; D005998:Glycine / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D009044:Motor Cortex / Q000378:metabolism / Q000473:pathology; D051381:Rats; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018846:Excitatory Amino Acids; D013654:Taurine; D001224:Aspartic Acid; D003035:Cobalt; D005680:gamma-Aminobutyric Acid; D005998:Glycine