DAPK1 is associated with FTD and not with Alzheimer's disease.
Apoptosis is correlated with various forms of dementia. Death-associated protein kinase 1 (DAPK1) plays an important role in neuronal apoptosis and could influence the pathology of late-onset Alzheimer's disease (LOAD) and frontotemporal dementia (FTD). It has been reported that two common polymorphisms (rs4878104 and rs4877365) are associated with LOAD, thus we examined the genotype and allele distributions of the above polymorphisms in 681 Italian subjects, including patients with LOAD and FTD. We showed a positive association between rs4878104 and FTD, suggesting a possible implication of the DAPK1 genetic variant in the susceptibility to FTD.
Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca, Florence, Italy. tedde@unifi.it
Andrea
A
Tedde
Irene
I
Piaceri
Silvia
S
Bagnoli
Ersilia
E
Lucenteforte
Silvia
S
Piacentini
Sandro
S
Sorbi
Benedetta
B
Nacmias
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D004247:DNA / Q000235:genetics; D064550:Death-Associated Protein Kinases; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007438:Introns / Q000235:genetics; D007558:Italy; D008297:Male; D009483:Neuropsychological Tests; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D051017:Apoptosis Regulatory Proteins; D004247:DNA; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases