Modeling HIV infection and therapies in humanized mice.
The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Switzerland. marc.nischang@usz.ch
Marc
M
Nischang
Gustavo
G
Gers-Huber
Annette
A
Audigé
Ramesh
R
Akkina
Robert F
RF
Speck
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D004195:Disease Models, Animal; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D051379:Mice; D016513:Mice, SCID / Q000145:classification / Q000235:genetics* / Q000502:physiology; D014766:Viremia / Q000503:physiopathology