[Preparation and in vitro release characteristics of vincristine sulphate loaded poly (butylcyanoacrylate) nanoparticles].
OBJECTIVE
To prepare vincristine sulphate loaded poly (butylcyanoacrylate) nanoparticles (VCR-PBCA-NPs) and to investigate the in vitro release charactersitics.


METHODS
VCR-PBCA-NPs were prepared by emulsion polymerization method, and characterized for morphology, particle size, drug encapsulation efficiency and loading efficiency. The formulation was optimized using central composite design and response surface methodology. In vitro release study of VCR-PBCA-NPs was performed by dialysis technique. Model fitting was used to determine the kinetics and to discuss the mechanism.


RESULTS
The nanoparticles were spherical and uniform with a mean diameter of (98.9 +/- 3.05) nm. The drug encapsulation efficiency and loading efficiency were (55.23 +/- 0.96)% and (7.87 +/- 0.11)%, respectively. In vitro release results showed that 63.66% of VCR was released from VCR-PBCA-NPs in 4 h, and the Weibull model fitted VCR release pattern best.


CONCLUSIONS
The VCR-PBCA-NPs prepared in this study showed sustained release compared with VCR solution.
Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. trfish211@163.com
Rong
R
Tan
Ying
Y
Liu
Nianping
N
Feng
Jihui
J
Zhao
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003487:Cyanoacrylates / Q000032:analysis*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004655:Emulsions; D004659:Enbucrilate / Q000737:chemistry*; D066298:In Vitro Techniques; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D014750:Vincristine / Q000737:chemistry*
D003487:Cyanoacrylates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D014750:Vincristine; D004659:Enbucrilate