[Therapy refractory polyarthritis and fever].
Primary manifestation of an autoinflammatory systemic disease was found in a 15-year-old patient, which initially ran a fulminant course. The course was first controlled by therapy with steroids and cyclosporin A. In the course of the disease, the patient developed a therapy refractory polyarthritis, which failed to respond to a combination of disease-modifying antirheumatic drugs (DMARDs) and tumor necrosis factor (TNF) inhibitors. A good disease control could only be achieved with an interleukin 6 (IL-6) blockade and DMARDs.
Klinik für Innere Medizin II, Rheumatologie/Klinische Immunologie, Klinikum Südstadt Rostock, Südring 81, 18059, Rostock, Deutschland. mathias.licht@kliniksued-rostock.de
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Licht
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Kyank
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Kneitz
D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D005334:Fever / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D013256:Steroids / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome
D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D013256:Steroids; D016572:Cyclosporine