Orchestrating cell/material interactions for tissue engineering of surgical implants.
Research groups are currently recognising a critical clinical need for innovative approaches to organ failure and agenesis. Allografting, autologous reconstruction and prosthetics are hampered with severe limitations. Pertinently, readily available 'laboratory-grown' organs and implants are becoming a reality. Tissue engineering constructs vary in their design complexity depending on the specific structural and functional demands. Expeditious methods on integrating autologous stem cells onto nanoarchitectured 3D nanocomposites, are being transferred from lab to patients with a number of successful first-in-man experiences. Despite the need for a complete understanding of cell/material interactions tissue engineering is offering a plethora of exciting possibilities in regenerative medicine.
UCL Centre for Nanotechnology & Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK.
Achala
A
de Mel
Alexander M
AM
Seifalian
Martin A
MA
Birchall
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D019736:Prostheses and Implants / Q000600:supply & distribution; D019651:Plastic Surgery Procedures; D044968:Regenerative Medicine / Q000379:methods; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds
D020099:Coated Materials, Biocompatible