[A clinico-pathological comparison between Henoch-Schonlein purpura nephritis and IgA nephropathy in children].
OBJECTIVE
To study the difference in clinico-pathological features between IgA nephropathy (IgAN) and Henoch-Schonlein purpura nephritis (HSPN) in children.


METHODS
The medical data of 103 children with HSPN and 61 children with IgAN were retrospectively studied.


RESULTS
There were no significant differences in age, sex and disease course between the HSPN and IgAN groups (P>0.05). Clinical classification demonstrated that more severe conditions were found in the IgAN group than in the HSPN group and gross hematuria was more common in the IgAN group (P<0.05). Serum creatinine and cholesterol levels were higher in the IgAN group than in the HSPN group (P<0.05). Fibrinogen-related antigen deposition was more common in the HSPN group, while complement 3(C3) deposition was more common in the IgAN group. Interstitial fibrosis, tubular casts and tubular inflammatory infiltration were also more common in the IgAN group (P<0.05).


CONCLUSIONS
Significant clinico-pathological differences can be found between HSPN and IgAN in children, and these differences do not support a one disease entity hypothesis.
Department of Pediatrics, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Hong-Xiang
HX
Guo
Jian-Jiang
JJ
Zhang
Pei-Pei
PP
Shi
Shu-Qin
SQ
Fu
Li-Guo
LG
Zhang
Miao
M
Wang
Feng-Xia
FX
Lu
D002648:Child; D002675:Child, Preschool; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000473:pathology*; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology / Q000473:pathology*; D007668:Kidney / Q000473:pathology*; D008297:Male; D009393:Nephritis / Q000276:immunology / Q000473:pathology*; D012189:Retrospective Studies