Change in platelet monoamine oxidase activity in the acutest period of ischemic stroke is associated with the degree of neurological recovery.
We studied monoamine oxidase activity (MAO) in platelets of patients in the acute period of ischemic stroke. Neurological deficit was evaluated by the data of clinical examinations and scales. In 80% patients MAO activity was considerably increased on 3-5 day after stroke. We found a correlation between increased MAO activity on 3-5 day after ischemic stroke and regression of neurological deficit on day 21 after ischemic stroke. The increase in MAO activity during the acute period of ischemic stroke is presumably a compensatory response aimed at stabilization of tissue homeostasis.
Moscow Institute of Psychiatry, Federal Agency for Health Care and Social Development, Russian State Medical University, Moscow, Russia. uzbekovmg@mtunet.ru
M G
MG
Uzbekov
V V
VV
Alferova
E Y
EY
Misionzhnik
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AB
Gekht
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D009422:Nervous System Diseases / Q000201:enzymology* / Q000503:physiopathology*; D020521:Stroke / Q000201:enzymology* / Q000503:physiopathology*
D008995:Monoamine Oxidase