Transcranial low level laser (light) therapy for traumatic brain injury.
We review the use of transcranial low-level laser (light) therapy (LLLT) as a possible treatment for traumatic-brain injury (TBI). The basic mechanisms of LLLT at the cellular and molecular level and its effects on the brain are outlined. Many interacting processes may contribute to the beneficial effects in TBI including neuroprotection, reduction of inflammation and stimulation of neurogenesis. Animal studies and clinical trials of transcranial-LLLT for ischemic stroke are summarized. Several laboratories have shown that LLLT is effective in increasing neurological performance and memory and learning in mouse models of TBI. There have been case report papers that show beneficial effects of transcranial-LLLT in a total of three patients with chronic TBI. Our laboratory has conducted three studies on LLLT and TBI in mice. One looked at pulsed-vs-continuous wave laser-irradiation and found 10 Hz to be superior. The second looked at four different laser-wavelengths (660, 730, 810, and 980 nm); only 660 and 810 nm were effective. The last looked at different treatment repetition regimens (1, 3 and 14-daily laser-treatments).
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Ying-Ying
YY
Huang
Asheesh
A
Gupta
Daniela
D
Vecchio
Vida J Bil
VJ
de Arce
Shih-Fong
SF
Huang
Weijun
W
Xuan
Michael R
MR
Hamblin
D000818:Animals; D001930:Brain Injuries / Q000532:radiotherapy*; D006801:Humans; D028022:Low-Level Light Therapy / Q000379:methods*; D012886:Skull; D020521:Stroke / Q000532:radiotherapy