Dermal penetration of bisphenol A in human skin contributes marginally to total exposure.
Bisphenol A (BPA) is ubiquitous and many exposure scenarios have been described during the last decades. While oral uptake is considered as the major route of exposure, the contribution of skin penetration has been recently discussed. In the present study, the dermal penetration rate of BPA has been determined in human skin in an in vitro test method according to the OECD Test Guideline 428. This analysis resulted in penetration of 8.6% and a total amount of bio-available BPA of 9.3% of the dose applied after 24h incubation under realistic exposure conditions. This confirms that the systemic exposure to BPA via the skin contributes in a negligible way to total systemic BPA exposure.
Federal Office of Public Health, Division of Chemicals, CH-3003 Berne, Switzerland. anne-laure.demierre@bag.admin.ch
Anne-Laure
AL
Demierre
Ronald
R
Peter
Aurelia
A
Oberli
Martine
M
Bourqui-Pittet
D001559:Benzhydryl Compounds; D001682:Biological Availability; D001822:Body Burden; D002102:Cadaver; D004785:Environmental Pollutants / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010636:Phenols / Q000378:metabolism* / Q000633:toxicity; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds