99mTc DPD is the preferential bone tracer for diagnosis of cardiac transthyretin amyloidosis.
We emphasize the role of Tc-99m-3,3-diphosphono-1,2-propanodicarboxylicacid (DPD) scintigraphy as a noninvasive tool to distinguish transthyretin (TTR)-related cardiac amyloidosis from other forms of cardiac amyloidosis. We report the case of a 76-year-old male patient suffering from congestive heart failure in whom imaging investigation by DPD scintigraphy showed a strong cardiac uptake highly suggestive of TTR amyloidosis variant. TTR-related cardiac amyloidosis was confirmed on myocardial biopsies by immunohistochemistry analysis. This case supports the growing interest in DPD scintigraphy for typing cardiac amyloidosis and for its contribution in the place of invasive myocardial biopsy.
Department of Internal Medicine, Public Hospitalsof Marseille, North Hospital, Marseille cedex, France.
Pascal
P
Rossi
Laurent
L
Tessonnier
Yves
Y
Frances
Olivier
O
Mundler
Brigitte
B
Granel
D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D011228:Prealbumin / Q000378:metabolism*; D011849:Radioactive Tracers; D011877:Radionuclide Imaging; D014463:Ultrasonography
D004164:Diphosphonates; D015609:Organotechnetium Compounds; D011228:Prealbumin; D011849:Radioactive Tracers; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid