Antidepressant effect of hypoxic preconditioning is associated with modification of expression of transcription factor c-Fos in rat brain in response to unavoidable stress.
Development of post-stress depression in rats was accompanied by long-term moderate activation of the expression of transcription factor c-Fos in the neocortex, hippocampus, and paraventricular nucleus of the hypothalamus. Hypoxic preconditioning preventing depressive state in rats under conditions of unavoidable stress considerably enhanced c-Fos expression in the studied brain regions during the early stages of stress response (days 1-5) and promoted its normalization at later terms (10 days). Disturbances in the wavy dynamics of c-Fos expression can contribute to the pathogenic mechanisms of depression, in particular and induce hyperproduction of hypothalamic neurohormone corticoliberin, whereas potentiation of early expression of this factor in response to stress is obviously necessary for prevention of post-stress disorders.
Laboratory of Regulation of Brain Neuron Functions, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. ksentippa@mail.ru
K A
KA
Baranova
E A
EA
Rybnikova
M O
MO
Samoilov
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis; D003863:Depression / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D004558:Electric Stimulation; D015870:Gene Expression; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D019579:Neocortex / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control
D016760:Proto-Oncogene Proteins c-fos; D003346:Corticotropin-Releasing Hormone; D010100:Oxygen