Myopia progression in Chinese children is slower in summer than in winter.
OBJECTIVE
To characterize seasonal variation in the myopic progression of Chinese children.


METHODS
Myopia progression data are presented for a total of 85 Chinese children, aged 6 to 12 years, with baseline myopia of -0.75 D to -3.50 D sphere and astigmatism ≤-1.50 D, who wore traditional single-vision spectacles in two clinical trials (trial A: n = 37, trial B: n = 48). Refractive error and axial length data were obtained at 6-month intervals using cycloplegic autorefraction and partial coherence interferometry, respectively. Progression rates for right eyes were defined for the first and second 6 months of the studies and classified in terms of "summer," "autumn," "winter," or "spring" based on the mid-point of the 6-month period between visits.


RESULTS
The mean 6-month spherical equivalent progression was -0.31 ± 0.25 D for summer, -0.40 ± 0.27 D for autumn, -0.53 ± 0.29 D for winter, and -0.42 ± 0.20 D for spring (p < 0.001). Mean axial elongation was 0.17 ± 0.10 mm for summer, 0.24 ± 0.09 mm for autumn, 0.24 ± 0.09 mm for winter, and 0.15 ± 0.08 mm for spring (p < 0.001). Post hoc analysis indicated that data for summer and winter were different from each other at p < 0.05 for both myopia progression and axial elongation after adjusting for age.


CONCLUSIONS
Myopia progression in summer months was approximately 60% of that seen in winter, and axial elongation was likewise significantly less in summer. It is unclear whether more time spent outdoors in summer vs. winter is a contributing factor, or the difference in progression rates is a result of "seasonal" variations in the intensity or amount of close work performed. These results indicate that studies of potential myopia treatment strategies should be at least 12 months in duration to take seasonal variations into account.
Brien Holden Vision Institute, Sydney, New South Wales, Australia. l.donovan@brienholdenvision.org
Leslie
L
Donovan
Padmaja
P
Sankaridurg
Arthur
A
Ho
Xiang
X
Chen
Zhi
Z
Lin
Varghese
V
Thomas
Earl L
EL
Smith
Jian
J
Ge
Brien
B
Holden
D002648:Child; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005139:Eyeglasses; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D047728:Myopia, Degenerative / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D012029:Refraction, Ocular / Q000502:physiology*; D012189:Retrospective Studies; D012621:Seasons