From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives.
Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.
Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, Moskovskaya st. 2, Krasnodar, 350072, Russian Federation.
Maxim G
MG
Uchuskin
Arkady S
AS
Pilipenko
Olga V
OV
Serdyuk
Igor V
IV
Trushkov
Alexander V
AV
Butin
D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D018533:Biomass; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D000962:Antimalarials; D026121:Indole Alkaloids; D007211:Indoles; D004364:Pharmaceutical Preparations; D011804:Quinolines; C577868:isocryptolepine