Synthesis and self-assembly of "tree-like" amphiphilic glycopolypeptides.
Novel synthetic tree-like oligosaccharides-grafted-polypeptides were prepared by using Huisgen 1,3-dipolar cycloaddition between poly(γ-benzyl-L-glutamate)-block-poly(propargylglycine) and two different oligosaccharides, dextran or hyaluronan. By direct solubilisation in water, these tree-like glycopeptides spontaneously form very small assemblies with sizes below 50 nm and low polydispersity.
Université de Bordeaux/IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France.
Colin
C
Bonduelle
Jin
J
Huang
Emmanuel
E
Ibarboure
Andreas
A
Heise
Sebastien
S
Lecommandoux
D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*
D006020:Glycopeptides; D013501:Surface-Active Agents