Sequential allenylidene/vinylidene cyclization for stereoselective construction of bicyclic carbocycles from propargyl alcohol.
Consecutive cyclization reactions of phenyl propargyl alcohols 1 and 2 are catalyzed by [Ru]NCCH(3)(+) ([Ru] = Cp(PPh(3))(2)Ru) in cosolvent CHCl(3)/MeOH at 60 °C, to afford the fused cyclic compounds 11a (R = Me) and 10a (R = Me), respectively.
Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
Hao-Wei
HW
Ma
Ying-Chih
YC
Lin
Shou-Ling
SL
Huang