Catecholamine regulation of stromal precursors and hemopoietic stem cells in cytostatic myelosuppression.
Effects of a sympatholytic drug on bone marrow stromal and hemopoietic precursors were studied on the model of cyclophosphamide-induced myelosuppression. Sympatholytic treatment increased the content of hemopoietic stem cells of different classes in the bone marrow. Selective stimulation of differentiation of polypotent precursors into granulocyte-macrophage precursors was noted. Acceleration of proliferation and maturation of granulocytic precursors was observed at later terms during regeneration of the hemopoietic tissue. The sympatholytic inhibited proliferation of stromal precursors and reduced feeder activity of fibroblasts for granulocyte precursors.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
A M
AM
Dygai
E S
ES
Khmelevskaya
E G
EG
Skurikhin
O V
OV
Pershina
T V
TV
Andreeva
N N
NN
Ermakova
D018759:Adrenergic Uptake Inhibitors / Q000008:administration & dosage*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000008:administration & dosage; D054697:Cytostatic Agents / Q000008:administration & dosage; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D039902:Multipotent Stem Cells / Q000187:drug effects / Q000378:metabolism; D038042:Myelopoiesis / Q000187:drug effects; D012110:Reserpine / Q000008:administration & dosage*; D017154:Stromal Cells / Q000187:drug effects* / Q000378:metabolism
D018759:Adrenergic Uptake Inhibitors; D002395:Catecholamines; D054697:Cytostatic Agents; D012110:Reserpine; D003520:Cyclophosphamide