Regulating the immune system via IL-15 transpresentation.
Transpresentation has emerged as an important mechanism mediating IL-15 responses in a subset of lymphocytes during the steady state. In transpresentation, cell surface IL-15, bound to IL-15Rα is delivered to opposing lymphocytes during a cell-cell interaction. The events most dependent on IL-15 include the development and homeostasis of memory CD8 T cells, Natural Killer cells, invariant Natural Killer T cells, and intraepithelial lymphocytes. As lymphocyte development and homeostasis involve multiple steps and mechanisms, IL-15 transpresentation can have diverse roles throughout. Moreover, distinct stages of lymphocyte differentiation require IL-15 transpresented by different cells, which include both hematopoietic and non-hematopoietic cell types. Herein, we will describe the points where IL-15 transpresentation impacts these processes, the specific cells thought to drive IL-15 responses, as well as their role in the course of development and homeostasis.
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Eliseo F
EF
Castillo
Kimberly S
KS
Schluns
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D019409:Interleukin-15 / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology
D019409:Interleukin-15