Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis.
This study explored the association of sepsis prognosis with dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its polymorphisms. We enrolled 80 subjects with sepsis and 80 controls. Serum sTREM-1 was tested on days 1, 3, 5, 7, 10, and 14. PCR sequencing was performed to detect TREM-1 genetic variation on its four exons. sTREM-1 levels were significantly higher in the nonsurvivor than in the survivor group (p < 0.001), and those at each time point were the same (p ≤ 0.001). Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). However, there was no relationship between TREM-1 polymorphism and dynamic concentration of sTREM-1. Logistic regression showed that sTREM-1, APACHE II, and rs2234237 polymorphism are risk factors for prognosis. Dynamic changes in serum sTREM-1 and rs2234237 polymorphism could be used in sepsis prognosis assessment.
Department of Respiratory Diseases, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province 572013, China.
Longxiang
L
Su
Changting
C
Liu
Cong
C
Li
Zhaoxu
Z
Jiang
Kun
K
Xiao
Xin
X
Zhang
Ming
M
Li
Peng
P
Yan
Dan
D
Feng
Lixin
L
Xie
D015415:Biomarkers / Q000097:blood; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011971:Receptors, Immunologic / Q000097:blood* / Q000235:genetics*; D012307:Risk Factors; D018805:Sepsis / Q000097:blood* / Q000235:genetics* / Q000401:mortality; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1