Breath biomarkers in diagnosis of pulmonary diseases.
Breath analysis provides a convenient and simple alternative to traditional specimen testing in clinical laboratory diagnosis. As such, substantial research has been devoted to the analysis and identification of breath biomarkers. Development of new analytes enhances the desirability of breath analysis especially for patients who monitor daily biochemical parameters. Elucidating the physiologic significance of volatile substances in breath is essential for clinical use. This review describes the use of breath biomarkers in diagnosis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), lung cancer, as well as other pulmonary diseases. A number of breath biomarkers in lung pathophysiology will be described including nitric oxide (NO), carbon monoxide (CO), hydrogen peroxide (H₂O₂) and other hydrocarbons.
Research Center of Analytical Instrumentation, Analytical and Testing Center, College of Chemistry, Sichuan University, Chengdu 610064, China.
Meigui
M
Zhou
Yong
Y
Liu
Yixiang
Y
Duan
D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis*; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D008171:Lung Diseases / Q000175:diagnosis*; D009569:Nitric Oxide / Q000032:analysis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology
D015415:Biomarkers; D009569:Nitric Oxide; D002248:Carbon Monoxide; D006861:Hydrogen Peroxide