Clinical characteristics of idiopathic pulmonary fibrosis patients with diabetes mellitus: the national survey in Korea from 2003 to 2007.
Evidence suggests that diabetes mellitus (DM) is associated with idiopathic pulmonary fibrosis (IPF). According to the new IPF guidelines, high-resolution computed tomography (HRCT) is an essential means of diagnosing IPF. We investigated the relationship between IPF and DM in patients treated between 2003 and 2007. Newly diagnosed IPF patients in large university teaching hospitals in Korea were enrolled from January 2003 to December 2007. We retrospectively analyzed 1,685 patients using the interstitial lung disease (ILD) registry. In total, 299 IPF patients (17.8%) also had DM. The mean age of our subjects was 68.0 ± 9.4 yr. HRCT showed significantly more reticular and honeycomb patterns in IPF patients with DM than in IPF patients without DM (P = 0.014, P = 0.028, respectively). Furthermore, significantly higher incidences of hypertension, cardiovascular diseases, and other malignancies (except lung cancer) were found in IPF patients with DM than in IPF patients without DM. In conclusion, IPF patients with DM are more likely to have the usual interstitial pneumonia (UIP) pattern, including reticular and honeycomb patterns, on HRCT than are those without DM.
Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Gachon University Gil Hospital, Incheon, Korea.
Yu Jin
YJ
Kim
Jeong-Woong
JW
Park
Sun Young
SY
Kyung
Sang Pyo
SP
Lee
Man Pyo
MP
Chung
Young Hwan
YH
Kim
Jae Ho
JH
Lee
Yong Chul
YC
Kim
Jong Seon
JS
Ryu
Hong Lyeol
HL
Lee
Choon Sik
CS
Park
Soo-Tak
ST
Uh
Young Chul
YC
Lee
Kwan Hyung
KH
Kim
Young Joon
YJ
Chun
Young Bum
YB
Park
Dong Soon
DS
Kim
Yongjin
Y
Jegal
Jin Hwa
JH
Lee
Moo Suk
MS
Park
Sung Hwan
SH
Jeong
D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed