Valproate-induced panhypogammaglobulinemia.
Valproate is one of the most used anti-epileptic drugs. Its common side effects are nausea, vomiting, weight gain, hair loss, tremor, changes in behavior, slowed thinking and impaired liver function. Blood dyscrasias are also relatively frequent and a few studies reported changes in serum immunoglobulin concentrations with valproate treatment. We describe a case of panhypogammaglobulinemia with transient pancytopenia due to valproate. Pancytopenia was recovered after discontinuation of valproate but panhypogammaglobulinemia has been persisting. Intravenous immunoglobulin is being administrated monthly. Previous reports describe that other sodium channel blockers, such as phenytoin and carbamazepine, have been associated with hypogammaglobulinemia. This report also suggests that immunodeficiencies can be caused by valproate.
Tae-Hoon
TH
Eom
Hyun-Seung
HS
Lee
Pil-Sang
PS
Jang
Young-Hoon
YH
Kim
D000361:Agammaglobulinemia / Q000139:chemically induced* / Q000150:complications; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D010198:Pancytopenia / Q000139:chemically induced* / Q000150:complications; D013226:Status Epilepticus / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid