Synthesis of functionalized cyclohexenone core of welwitindolinones via rhodium-catalyzed [5 + 1] cycloaddition.
The cyclohexenone core of welwitindolinones was synthesized by a Rh(I)-catalyzed [5 + 1]-cycloaddition of an allenylcyclopropane with CO. A pentasubstituted cyclopropane was prepared successfully by a Rh(II)-catalyzed intramolecular cyclopropanation of alkenes with chlorodiazoacetates.
School of Pharmacy, University of Wisconsin , Madison, Wisconsin 53705, United States.
Min
M
Zhang
Weiping
W
Tang
D002384:Catalysis; D003500:Cyclization; D061565:Cycloaddition Reaction; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D026121:Indole Alkaloids / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D003512:Cyclohexanones; D003516:Cycloparaffins; D003521:Cyclopropanes; D026121:Indole Alkaloids; C507638:welwitindolinone A; C546298:welwitindolinone B; D012238:Rhodium