Sleep disturbances and circadian CLOCK genes in borderline personality disorder.
Borderline personality disorder (BPD) is characterised by a deep-reaching pattern of affective instability, incoherent identity, self-injury, suicide attempts, and disturbed interpersonal relations and lifestyle. The daily activities of BPD patients are often chaotic and disorganized, with patients often staying up late while sleeping during the day. These behavioural patterns suggest that altered circadian rhythms may be associated with BPD. Furthermore, BPD patients frequently report suffering from sleep disturbances. In this review, we overview the evidence that circadian rhythms and sleep are disturbed in BPD, and we explore the possibility that personality traits that are pertinent for BPD may be associated with circadian typology, and perhaps to circadian genotypes. With regards to sleep architecture, we review the evidence that BPD patients display altered non-REM and REM sleep. A possible cue to a deeper understanding of this temporal dysregulation might be an analysis of the circadian clock at the molecular and cellular level, as well as behavioural studies using actigraphy and we suggest avenues for further exploration of these factors.
Department of Psychiatry and Psychotherapy, University Hospital Rostock, Gehlsheimer Straße 20, 18147 Rostock, Germany.
Monika
M
Fleischer
Michael
M
Schäfer
Andrew
A
Coogan
Frank
F
Häßler
Johannes
J
Thome
D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000150:complications* / Q000235:genetics*; D056926:CLOCK Proteins / Q000235:genetics* / Q000378:metabolism; D002220:Carbamazepine / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D010551:Personality / Q000235:genetics; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000235:genetics
D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine; D056926:CLOCK Proteins