Capecitabine may induce coronary artery vasospasm.
Capecitabine is a new oral chemotherapeutic agent that is considered highly specific for sensitive tumor cells. We present the case of a patient who, after treatment with capecitabine for colorectal cancer, presented to our hospital with angina pectoris and electrocardiographic changes indicative of myocardial ischemia. The absence of epicardial coronary stenosis on the coronary angiogram ruled out atherosclerotic coronary disease as the cause of ischemia. The occurrence of coronary spasm, although not evident during coronary angiography, seems to be a possible explanation of the patient's symptoms.
First Department of Cardiology, Hippokration Hospital, University of Athens, Greece.
Eleutherios
E
Tsiamis
Andreas
A
Synetos
Christodoulos
C
Stefanadis
D000787:Angina Pectoris / Q000139:chemically induced / Q000175:diagnosis; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000175:diagnosis
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D004317:Doxorubicin; D005472:Fluorouracil