Total synthesis and complete stereostructure of gambieric acid A.
Total synthesis of gambieric acid A, a potent antifungal polycyclic ether metabolite, has been accomplished for the first time, which firmly established the complete stereostructure of this natural product.
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. hfuwa@bios.tohoku.ac.jp
Haruhiko
H
Fuwa
Kazuya
K
Ishigai
Keisuke
K
Hashizume
Makoto
M
Sasaki
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D004141:Dinoflagellida / Q000737:chemistry*; D008968:Molecular Conformation
D000935:Antifungal Agents; D001688:Biological Products; D002922:Ciguatoxins; C080898:gambieric acid A