Effect of chitosan intake on fecal excretion of dioxins and polychlorinated biphenyls in healthy men.
Six healthy male subjects were treated with 0 g, 1 g, 3 g, and 0 g of chitosan for the first, second, third, and fourth of four weeks, respectively. They were administered chitosan before breakfast on the second, third, and fourth days of the week, and fecal specimens were collected corresponding to the prescribed diet consumed for breakfast on the second day to breakfast on the fourth day. Fecal excretion of dioxins and polychlorinated biphenyls (PCBs) was promoted by intake of 3 g of chitosan (p=0.0589 and p<0.05 respectively), and was positively correlated with that of fat (p<0.01 for both). We found that chitosan intake increased the fecal excretion of dioxins and PCBs, as well as that of fat, suggesting that it might be useful for reducing the adverse effects of lipophilic endocrine-disrupting chemicals.
Otsu Nutraceuticals Research Institute, Nutraceuticals Division, Otsuka Pharmaceutical Co., Ltd., Shiga, Japan. Kohda.Noriyuki@otsuka.jp
Noriyuki
N
Kohda
Shoichiro
S
Inoue
Tsuneyuki
T
Noda
Takao
T
Saito
D000284:Administration, Oral; D000328:Adult; D048271:Chitosan / Q000008:administration & dosage*; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism; D004147:Dioxins / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005243:Feces / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*; D011795:Surveys and Questionnaires
D004041:Dietary Fats; D004147:Dioxins; D048271:Chitosan; D011078:Polychlorinated Biphenyls