Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies.
RNA helicases are ubiquitous in plants and animals and function in many cellular processes. Retroviruses, such as human immunodeficiency virus (HIV-1), encode no RNA helicases in their genomes and utilize host cellular RNA helicases at various stages of their life cycle. Here, we briefly summarize the roles RNA helicases play in HIV-1 replication that have been identified recently, in part, through genome-wide screenings, proteomics, and molecular studies. Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication.
Molecular Virology Section 1, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.
Chia-Yen
CY
Chen
Xiang
X
Liu
Kathleen
K
Boris-Lawrie
Amit
A
Sharma
Kuan-Teh
KT
Jeang
D000818:Animals; D015967:Gene Expression Regulation, Viral; D016678:Genome; D015658:HIV Infections / Q000201:enzymology* / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D040901:Proteomics; D020365:RNA Helicases / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication
D020365:RNA Helicases