Neuroprotective properties of aucubin in diabetic rats and diabetic encephalopathy rats.
In this study, we determined the neuroprotective effect of aucubin on diabetes and diabetic encephalopathy. With the exception of the control group, all rats received intraperitoneal injections of streptozotocin (STZ; 60 mg/kg) to induce type 1 diabetes mellitus (DM). Aucubin (1, 5, 10 mg/kg ip) was used after induction of DM (immediately) and diabetic encephalopathy (65 days after the induction of diabetes). The diabetic encephalopathy treatment groups were divided into short-term and long-term treatment groups. Treatment responses to all parameters were examined (body weight, plasma glucose, Y-maze error rates and proportion of apoptotic cells). In diabetic rats, aucubin controlled blood glucose levels effectively, prevented complications, and improved the quality of life of diabetic rats. In diabetic encephalopathy, aucubin significantly rescued neurons in the hippocampal CA1 subfield and reduced working errors during behavioral testing. The significant neuroprotective effect of aucubin could be seen not only in the short term (15 days) but also in the long term (45 days), which was a highly encouraging finding. These data suggest that aucubin may be a potential neuroprotective agent.
Department of Chemistry and Life Science, Suzhou University, No. 49 Middle Bianhe Road, Yongqiao District, Suzhou, 234000 Anhui, People's Republic of China.
Hong Yu
HY
Xue
Ya Nan
YN
Lu
Xue Mei
XM
Fang
Yong Ping
YP
Xu
Gui Zhen
GZ
Gao
Li Ji
LJ
Jin
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D001928:Brain Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D057888:Iridoid Glucosides / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017966:Pyramidal Cells / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D057888:Iridoid Glucosides; D018696:Neuroprotective Agents; C006650:aucubin