[Expression and correlation of cyclooxygenase-2 and vascular endothelial growth factor in nasopharyngeal carcinoma-].
OBJECTIVE
To evaluate the Expression and correlation of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor receptor (VEGF) in nasopharyngeal carcinoma.


METHODS
In this study, expression levels of COX-2, VEGF were examined in 58 patients with nasopharyngeal carcinoma and 38 patients with inflammation in nasopharyngeal mucosa by immunohistochemistry method.


RESULTS
The expression of COX-2, VEGF were higher in nasopharyngeal carcinoma than those in nasopharyngeal mucosa (P < 0.05), and they had some correlation with the invasion and lymphatic metastasis and with the clinical stage of nasopharyngeal carcinoma (P < 0.05). The expression of COX-2 was positively correlated with that of VEGF (P < 0.05).


CONCLUSIONS
The coexpression of COX-2 and VEGF may play animportant role in the carcinogenesis and development of nasopharyngeal carcinoma, and they may prom (see text) lymph node metastasis of nasopharyngeal carcinoma.
Department of Otorhinolaryngology, Second Hospital of Ningbo, Ningbo 315000, China. baiweiqi1117@gmail.com
Weiqi
W
Bai
Baohua
B
Hu
Jianguo
J
Tang
Xuan
X
Li
Rong
R
Huang
Jixia
J
Yu
Liping
L
Gu
D002277:Carcinoma; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009092:Mucous Membrane / Q000378:metabolism; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009304:Nasopharyngitis / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*
D009363:Neoplasm Proteins; D051546:Cyclooxygenase 2; D040262:Receptors, Vascular Endothelial Growth Factor