Toward an integrative view of Optineurin functions.
This review highlights recent advances in our understanding of the mechanisms of Optineurin (Optn) action and its implication in diseases. Optn has emerged as a key player regulating various physiological processes, including membrane trafficking, protein secretion, cell division and host defense against pathogens. Furthermore, there is growing evidence for an association of Optn mutations with human diseases such as primary open-angle glaucoma, amyotrophic lateral sclerosis and Paget's disease of bone. Optn functions depend on its precise subcellular localization and its interaction with other proteins. Here, we review the mechanisms that allow Optn to ensure a timely and spatially coordinated integration of different physiological processes and discuss how their deregulation may lead to different pathologies.
Institut Pasteur, Unité de Signalisation Moléculaire et Activation Cellulaire, CNRS URA 2582, Paris, France.
David
D
Kachaner
Pierre
P
Génin
Emmanuel
E
Laplantine
Robert
R
Weil
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D000818:Animals; D017209:Apoptosis; D001692:Biological Transport; D018797:Cell Cycle Proteins; D002455:Cell Division; D005901:Glaucoma / Q000235:genetics*; D006801:Humans; D026901:Membrane Transport Proteins; D016328:NF-kappa B / Q000378:metabolism; D010001:Osteitis Deformans / Q000235:genetics*; D035582:Transcription Factor TFIIIA / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D026901:Membrane Transport Proteins; D016328:NF-kappa B; C409460:OPTN protein, human; D035582:Transcription Factor TFIIIA