[Study on the iodine status of pregnant women and thyroid function of neonate in high iodine area].
OBJECTIVE
To reveal the iodine status of pregnant women and its impact on thyroid function of neonates in high iodine area.


METHODS
A total of 210 pregnant women were chosen from a hospital in Haixing county, Hebei province. Pregnant women's random urinary and neonates' cord blood were collected. The urinary iodine concentration (UIC) was examined by arsenic-cerium catalytic spectrophotometry. The levels of free triiodothyronine (FT3), free thyroxine (FT4) and sensitive thyroid-stimulating hormone (sTSH) in serum were measured by chemiluminescence.


RESULTS
The age of 210 pregnant women was (27.69 +/- 4.73) years old, whose urinary iodine median (inter-quartile range ) was 1240.70 (1292.68) microg/L. 84.3% (177/210) of the pregnant women had excessive iodine intake (UIC > or = 500 microg/L), 13.8% (29/210) had more than adequate iodine intake( UIC within 250 - 499 microg/L), 0.5% (1/210) had adequate iodine intake (UIC within 150 - 249 microg/L) and 1.4% (3/210) had insufficient iodine intake (UIC < 150 microg/L). The average serum level of FT3, FT4 in neonates were (2.93 +/- 0.59), (15.03 +/- 1.92) pmol/L, respectively. The median (inter-quartile range) of serum sTSH in neonates were 7.33 (5.59) mU/L 78.1% (164/210) of the neonates' serum TSH were beyond 5 mU/L. There were no correlation between pregnant women's urinary iodine level and neonates' serum FT3 and sTSH level (P > 0.05), but there was a positive correlation between pregnant women's urinary iodine level and neonates' serum FT4 level (P < 0.01). Serum FT4 level of the neonates with whose mothers had insufficient iodine intake ((12.99 +/- 1.10) pmol/L) were statistically lower than those with their mothers had excessive iodine intake (15.16 +/- 1.83) pmol/L) (P < 0.05).


CONCLUSIONS
Most of the pregnant women in high iodine area were excessive for iodine nutrition, but still a few pregnant women had insufficient iodine nutrition. The level of neonates' serum sTSH were relatively high and monitoring of risk of hypothyroidism and subclinical hypothyroidism should be strengthened.
Department of Nutrition and Food Hygiene, College of Public Health, Tianjin Medical University, Tianjin 300070, China.
Gui-Qin
GQ
Zhang
Zhong-Na
ZN
Sang
Hua
H
Liu
Shu-Fen
SF
Zhang
Wei
W
Wei
Na
N
Zhao
Long
L
Tan
Wan-Qi
WQ
Zhang
D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology; D007231:Infant, Newborn; D007455:Iodine / Q000652:urine*; D009752:Nutritional Status; D011247:Pregnancy; D013960:Thyroid Function Tests; D013961:Thyroid Gland; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D019371:Topography, Medical; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine