Experimental study of the effects of Dietressa, a new weight-reducing drug.
The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of drug action were analyzed, and its safety (abuse potential in the reaction of self-stimulation) was evaluated. Dietressa was not inferior to sibutramine in reducing body weight gain in mice and exhibited no abuse potential.
Materia Medica Holding, Moscow, Russia. nauka@materiamedica.ru
I A
IA
Kheyfets
L I
LI
Bugaeva
T M
TM
Vorob'eva
J L
JL
Dugina
S A
SA
Lebedeva
V I
VI
Petrov
S A
SA
Sergeeva
O I
OI
Epstein
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D000906:Antibodies / Q000494:pharmacology*; D003503:Cyclobutanes / Q000378:metabolism / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004435:Eating / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D009765:Obesity / Q000517:prevention & control*; D043884:Receptor, Cannabinoid, CB1 / Q000276:immunology*; D015431:Weight Loss / Q000187:drug effects*
D019440:Anti-Obesity Agents; D000906:Antibodies; C543264:Cnr1 protein, rat; D003503:Cyclobutanes; C000605985:Dietressa; D043884:Receptor, Cannabinoid, CB1; C058254:sibutramine