Long-term survival in a dog with anaplastic oligodendroglioma treated with radiation therapy and CCNU.
A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2 months after RT, recurrence was observed at 4 months after RT. Chemotherapy was started using CCNU (60 mg/m(2) every 6-9 weeks) and was continued for one year. Follow-up MRI revealed involution of the lesion and the intervals of CCNU were increased to every 9-14 weeks. Two years after the first presentation, the dog suffered status epilepticus, followed by deficits of left sided postural reaction with cognitive dysfunction. The dog died on day 910, and histopathological diagnosis confirmed anaplastic oligodendroglioma.
Division of Veterinary Radiology, Department of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan. disk-hsgw@nvlu.ac.jp
Daisuke
D
Hasegawa
Kazuyuki
K
Uchida
Takayuki
T
Kuwabara
Shunta
S
Mizoguchi
Naoko
N
Yayoshi
Michio
M
Fujita
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008130:Lomustine / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D009837:Oligodendroglioma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D010315:Particle Accelerators; D013226:Status Epilepticus / Q000209:etiology / Q000473:pathology / Q000662:veterinary*
D008130:Lomustine