[Prognostic analysis of 76 cases with adenoid cystic carcinoma in salivary gland].
OBJECTIVE
To investigate the prognosis of adenoid cystic carcinoma (ACC) in salivary gland and its influencing factors.


METHODS
Clinical and following-up data of 76 patients with ACC in salivary glands were reviewed. Major gland tumors represented 35.5% whereas minor gland tumors comprised 64.5% of the cohort, with 8 cases (10.5%) in stage I, 23 (30.3%) in stage II, 18 (23.7%) in stage III and 27(35.5%) in stage IV. Survival rates were calculated by Kaplan-Merier method. Cumulative survival curves were evaluated using the Log-rank test. Multivariate analysis was performed by Cox proportional hazard model.


RESULTS
The regional recurrence rate was 28.9% and distant metastasis rate was 21.1%. The overall 5-year survival rate, tumor-free survival rate and tumor-related survival rate were 73.7%, 61.8% and 74.9% respectively. The overall 10-year survival rate, tumor-free survival rate and tumor-related survival rate were 48.2%, 39.8% and 56.2% respectively. Univariate survival analysis showed pathological type, clinical stage and perineural invasion were relevant to the prognosis of ACC and multivariate analysis showed they were the independent prognostic factors of ACC in salivary gland.


CONCLUSIONS
Clinical stage, pathological type and perineural invasion were the independent prognostic factors for adenoid cystic carcinoma in salivary gland. Surgery was the first choice for the treatment of adenoid cystic carcinoma in salivary gland, and postoperative radiotherapy may prolong the tumor-free survival time of patients in stage III and IV.
Department of Head and Neck Surgery, Zhejiang Tumor Hospital, Hangzhou 310022, China. gemingh@163.com
Ming-hua
MH
Ge
Jia-feng
JF
Wang
Qing-min
QM
Xia
Zhuo
Z
Tan
Jia-jie
JJ
Xu
Chao
C
Chen
Ke-jing
KJ
Wang
Xiang-rong
XR
Tan
D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000175:diagnosis*; D015996:Survival Rate; D055815:Young Adult