[Preparation and quality control of pyridostigmine bromide orally disintegrating tablet].
OBJECTIVE
To prepare orally disintegrating tablets containing pyridostigmine bromide and optimize formulations.


METHODS
Solid dispersion was prepared using solvent evaporation-deposition method. The formulation was optimized by central composite design-response surface methodology (RSM plus CCD) with disintegration time as a reference parameter.


RESULTS
The orally disintegrating tablets showed integrity and were smooth with desirable taste and feel in mouth. The disintegration time was less than 30 s. The cumulative drug dissolution was around 8.5% (around 2.5 mg which was less than bitterness threshold of pyridostigmine bromide of 3 mg) within 5 min in water while the cumulative drug dissolution was higher than 95% within 2 min in 0.1 N HCl.


CONCLUSIONS
The orally disintegrating tablets are reasonable in formulation, feasible in technology and patient-friendly.
Medicine Engineering Research Center in University, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
Li
L
Zhang
Qun-you
QY
Tan
Xun-guan
XG
Cheng
Hong
H
Wang
Ni-ni
NN
Hu
Jing-qing
JQ
Zhang
D000278:Administration, Buccal; D002626:Chemistry, Pharmaceutical; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D011729:Pyridostigmine Bromide / Q000008:administration & dosage*; D011786:Quality Control; D013607:Tablets / Q000008:administration & dosage; D013649:Taste
D002800:Cholinesterase Inhibitors; D013607:Tablets; D011729:Pyridostigmine Bromide