Significant hypotension following buccal midazolam administration.
Buccal midazolam is a rescue medication to reduce the duration of or stop an epileptic seizure, and is used to prevent status epilepticus. It is available in various forms, including a buccal preparation with a strength of 10 mg/1 ml. Midazolam is a licensed medication, but the buccal formulation is currently used off-licence. The prescriber takes ultimate responsibility for its use in this way. Administered by a trained person, it is receiving widespread acceptance as an alternative and effective treatment to rectally-administered diazepam in the community. The commonest side effects of midazolam are drowsiness and somnolence, although respiratory depression and paradoxical reactions, for example, agitation, restlessness and disorientation, may also occur. Hypotension is said to be a rare side effect, but with no reported cases in people administered buccal midazolam. The authors report a case of significant hypotension associated with administration of buccal midazolam for seizure management.
Institute of Neurology, University College London, London, UK. maria.kensche@charite.de
Maria
M
Kensche
Josemir W
JW
Sander
Sanjay M
SM
Sisodiya
D000278:Administration, Buccal; D004827:Epilepsy / Q000188:drug therapy; D018757:GABA Modulators / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index; D055815:Young Adult
D018757:GABA Modulators; D008874:Midazolam