Uncommon leukemic case of anaplastic large cell lymphoma diagnosed through a typical chromosomal abnormality t(2;5) with a null phenotype and aberrant expression of NG2 and CD13.
Anaplastic large cell lymphoma represents approximately 10-15 % of pediatric non-Hodgkin lymphomas. Leukemic presentation is very rare, and in particular, the null phenotype ALCL without typical anaplastic morphology together with aberrant expression of CD13 and/or CD11b represents a diagnostic challenge. We report a case of a 9 year-old boy with leukemic presentation of ALCL with the typical translocation t(2;5)(p23;q35); in this patient, the only positive antigens identified by immunophenotyping were CD13, NG2 HLA-DR, and CD38. To our knowledge, aberrant expression of NG2 has never been reported in ALCL cases (Tab. 1, Fig. 6, Ref. 20).
Department of Pediatric Oncology, Comenius University, Bratislava, Slovakia. sasa.kolenova@gmail.com
A
A
Kolenova
E
E
Mejstrikova
K
K
Fidlerova
E
E
Fronkova
L
L
Plank
P
P
Szepe
J
J
Jindrova
D
D
Sejnova
A
A
Zakovicova
E
E
Kaiserova
D000941:Antigens / Q000378:metabolism*; D018826:CD13 Antigens / Q000378:metabolism*; D002648:Child; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D016130:Immunophenotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D008297:Male; D011509:Proteoglycans / Q000378:metabolism*; D014178:Translocation, Genetic; D000099216:Chondroitin Sulfate Proteoglycan 4
D000941:Antigens; D018826:CD13 Antigens; D011509:Proteoglycans; D000099216:Chondroitin Sulfate Proteoglycan 4