Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome.
The evolution of the metabolic syndrome in afflicted individuals is, in part, characterized by the development of a severely pro-oxidant state within the vasculature. It has been previously demonstrated by many investigators that this increasingly pro-oxidant state can have severe negative implications for many relevant processes within the vasculature, including the coordination of dilator/constrictor tone or reactivity, the structural adaptations of the vascular wall or distal networks, as well as the integrated regulation of perfusion resistance across and throughout the vascular networks. The purpose of this review article is to present the different sources of oxidant stress within the setting of the metabolic syndrome, the available mechanism for attempts at regulation and the vascular outcomes associated with this condition. It is anticipated that this overview will help readers and investigators to more effectively design experiments and interpret their results within the extremely complicated setting of metabolic syndrome.
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States.
Adam G
AG
Goodwill
Jefferson C
JC
Frisbee
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D024821:Metabolic Syndrome / Q000209:etiology / Q000503:physiopathology*; D008833:Microcirculation; D055806:Microvessels / Q000473:pathology; D018482:Muscle, Skeletal / Q000098:blood supply; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012307:Risk Factors; D014652:Vascular Diseases / Q000503:physiopathology*
D017382:Reactive Oxygen Species; D009569:Nitric Oxide