pH-triggered blooming of 'nano-flowers' for tumor intracellular drug delivery.
With the decrease in pH value, the 'nano-flower' exhibited a half-open state to expose the target ligands on the surface under tumor acidic conditions and fully bloomed to release Dox under endosomal acidic conditions.
Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, PR China.
Zhefan
Z
Yuan
Zhenyang
Z
Que
Sixue
S
Cheng
Renxi
R
Zhuo
Feng
F
Li
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D008823:Micelles; D004317:Doxorubicin