Effect of antiserotonin drug on the development of lung fibrosis and blood system reactions after intratracheal administration of bleomycin.
The effects of antiserotonin preparation on the development of the connective tissue in the lungs, reaction of the blood system, and the content of hemopoietic stem cells, committed hemopoietic and stromal precursors in BM, spleen, and peripheral blood were studied on C57Bl/6 mice with experimental toxic lung fibrosis caused by intratracheal administration of bleomycin. It was demonstrated that the antiserotonin drug inhibits the growth of the connective tissue in the lungs and attenuates the course inflammatory process primarily due to inhibition of the granulocytic lineage, which was related to suppression of hemopoietic stem cells. Reduced content of the stromal precursor cells in BM and spleen was noted.
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
E G
EG
Skurikhin
T V
TV
Andreeva
E S
ES
Khmelevskaya
L A
LA
Ermolaeva
O V
OV
Pershina
V A
VA
Krupin
N N
NN
Ermakova
A M
AM
Reztsova
I E
IE
Stepanova
V E
VE
Gol'dberg
A M
AM
Dygai
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003533:Cyproheptadine / Q000008:administration & dosage*; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology; D007274:Injections, Intraperitoneal; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012702:Serotonin Antagonists / Q000008:administration & dosage*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017154:Stromal Cells / Q000187:drug effects / Q000473:pathology
D012702:Serotonin Antagonists; D001761:Bleomycin; D003533:Cyproheptadine