Serum anti-Mullerian hormone levels affect the rate of ongoing pregnancy after in vitro fertilization.
We used logistic regression analysis to investigate the relationship between serum anti-Mullerian hormone (AMH) levels and the rate of ongoing pregnancy. Retrospective data were collected from 1043 women who had undergone their first cycle of in vitro fertilization (IVF), including 540 cycles of fresh embryo transfer and 503 cycles of frozen-thawed embryo transfer. The patients were divided into 4 groups based on the cutoff values from a receiver-operating characteristic curve: 0.0 to 12.4, 12.5 to 25.5, 25.6 to 44.1, and >44.2 pmol/L. After adjustment for multiple confounders, the serum AMH group was found to be significantly related to the rate of ongoing pregnancy in total cycles (0.0-12.4 vs 12.5-25.5 pmol/L; P = .0088, odds ratio, 1.909: vs 25.6-44.1 pmol/L; P = .0281, odds ratio, 2.109: vs >44.2 pmol/L; P = .0008, odds ratio, 2.840). In conclusion, there appears to be a significant relationship between serum AMH levels and the ongoing pregnancy rate in first IVF treatment cycles after adjustment for multiple confounders.
Asada Ladies' Clinic, Kasugai, Aichi, Japan. hihonma@sapmed.ac.jp
Hiroyuki
H
Honnma
Tsuyoshi
T
Baba
Masahiro
M
Sasaki
Yoshiki
Y
Hashiba
Hisanori
H
Oguri
Takanori
T
Fukunaga
Toshiaki
T
Endo
Yoshimasa
Y
Asada
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004624:Embryo Transfer / Q000639:trends; D005260:Female; D005307:Fertilization in Vitro / Q000639:trends*; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies
D015415:Biomarkers; D054304:Anti-Mullerian Hormone