Elevated levels of oxidative stress as a prognostic predictor of major adverse cardiovascular events in patients with coronary artery disease.
OBJECTIVE
To evaluate the prognostic significance of oxidative stress on the rate of major adverse cardiovascular events (MACEs: cardiac and all-cause death, nonfatal myocardial infarction, coronary revascularization-PTCA/CABG) in CAD.


METHODS
We studied 97 angiographically proven CAD patients (78 males, age: 67±11 years, mean± SD). Reactive oxygen metabolites and total antioxidant status, assessed by commercially assays (d-ROMs and OXY-Adsorbent Test; Diacron, Grosseto, GR, Italy), were used to calculate the oxidant/antioxidant balance. Patient data were collected from the Institute's electronic databank, which saves demographic, clinical, instrumental and follow-up data of all patients admitted to our department.


RESULTS
Kaplan-Meier survival estimates showed a significantly worst outcome in patients presenting with elevated oxidative stress levels (>75th percentile, p<0.01). Multivariate Cox models showed that a higher level of oxidative stress was an independent predictor of developing MACEs (hazard ratio=2.1, confidence intervals 1.2-3.6, p<0.01).


CONCLUSIONS
Oxidative stress may represent a useful additional tool in the prediction of MACE in CAD.
Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy. cristina.vassalle@ftgm.it
Cristina
C
Vassalle
Sara
S
Bianchi
Debora
D
Battaglia
Patrizia
P
Landi
Fabrizio
F
Bianchi
Clara
C
Carpeggiani
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012307:Risk Factors; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
D000975:Antioxidants; D017382:Reactive Oxygen Species