Synthesis, surface modification, characterization, and biomedical in vitro applications of organically modified silica (ORMOSIL) nanoparticles.
Organically modified silica (ORMOSIL) nanoparticles, owing to the presence of lipophilic organic groups, can host active lipophilic molecules in their interior, as well as form electrostatic complex with therapeutic agents such as genes on their surface. Owing to this fact, they have numerous potential applications in diagnostic imaging, as well as drug, and gene delivery. Here we describe the synthesis, characterization, and biomedical applications of ORMOSIL nanoparticles encapsulated with either an anticancer drug (for cancer chemotherapy), or a photosensitizer drug (for photodynamic therapy), or complexed with a plasmid DNA (for gene therapy).
Department of Chemistry, University of Delhi, Delhi, India.
Diksha
Indrajit
I
Roy
D045744:Cell Line, Tumor; D002470:Cell Survival; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000008:administration & dosage; D010957:Plasmids; D012822:Silicon Dioxide / Q000737:chemistry*; D014162:Transfection
D004655:Emulsions; D017319:Photosensitizing Agents; D012822:Silicon Dioxide; D004317:Doxorubicin