Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?
The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8 M hydrochloric acid as a function of temperature (57, 73, 90, and 100 °C). It is found that PEtOx undergoes negligible hydrolysis at 37 °C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.
Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium.
Huub P C
HP
Van Kuringen
Joke
J
Lenoir
Els
E
Adriaens
Johan
J
Bender
Bruno G
BG
De Geest
Richard
R
Hoogenboom
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D040761:Biomimetic Materials / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002849:Chromatography, Gas; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005750:Gastric Juice / Q000201:enzymology; D049851:Gastropoda / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006851:Hydrochloric Acid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature; D013818:Thermogravimetry
D001672:Biocompatible Materials; D011073:Polyamines; C511916:poly(2-ethyl-2-oxazoline); D006851:Hydrochloric Acid