Exenatide enhances kaliuresis under conditions of hyperkalemia.
Experiments on Wistar rats showed that exenatide (0.015-0.5 nmol per 100 g body weight) somewhat increased renal excretion of potassium from 7±1 to 16±1 μmol/h/100 g body weight (p<0.05) in animals with normal serum concentration of glucose (4.6±0.4 mM) and potassium (4.3±0.1 mM). Exenatide dramatically enhanced excretion of potassium under conditions of hyperkalemia (11.4±0.4 mM) produced by intraperitoneal injection of 1.25% KCl solution (5 ml per 100 g body weight). During the first postinjection hour, potassium excretion increased 2-fold and attained 97±11 μmol/h/100 g body weight in comparison with potassium load alone (47±9 μmol/h/100 g body weight, p<0.05). The data attest to a possible role of peptide regulators in normalization of potassium balance via renal mechanisms.
I. M. Sechenov Institute of Evolution Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
A S
AS
Marina
A V
AV
Kutina
Yu V
YV
Natochin
D000818:Animals; D000077270:Exenatide; D005260:Female; D006947:Hyperkalemia / Q000139:chemically induced / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D010455:Peptides / Q000627:therapeutic use*; D011188:Potassium / Q000378:metabolism*; D011189:Potassium Chloride / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014688:Venoms / Q000627:therapeutic use*
D010455:Peptides; D014688:Venoms; D011189:Potassium Chloride; D000077270:Exenatide; D011188:Potassium