Airborne transmission of Bordetella pertussis.
Pertussis is a contagious, acute respiratory illness caused by the bacterial pathogen Bordetella pertussis. Although it is widely believed that transmission of B. pertussis occurs via aerosolized respiratory droplets, no controlled study has ever documented airborne transmission of pertussis. We set out to determine if airborne transmission occurs between infected and naive animals, utilizing the baboon model of pertussis. Our results showed that 100% of exposed naive animals became infected even when physical contact was prevented, demonstrating that pertussis transmission occurs via aerosolized respiratory droplets.
Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA.
Jason M
JM
Warfel
Joel
J
Beren
Tod J
TJ
Merkel
D000336:Aerosols; D000391:Air Microbiology; D000818:Animals; D001886:Bordetella pertussis / Q000502:physiology*; D006801:Humans; D007964:Leukocytosis; D010215:Papio; D013997:Time Factors; D014917:Whooping Cough / Q000382:microbiology* / Q000635:transmission*
D000336:Aerosols