Geroprotective effects of activation of D-GADD45 DNA reparation gene in Drosophila melanogaster nervous system.
The expression of D-GADD45 gene involved in DNA reparation in Drosophila melanogaster decreases with age. Overexpression of D-GADD45 in the drosophila nervous system prolongs the median and maximum life span without deterioration of the quality of life parameters (fertility and neuromuscular activity). The life span prolongation effect is due to more effective DNA reparation, as spontaneous level of DNA aberrations in the nerve tissue of larvae with D-GADD45 overexpression is reduced significantly.
Institute of Biology, Komi Research Center, Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia.
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Plyusnina
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MV
Shaposhnikov
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Moskalev
D000367:Age Factors; D000818:Animals; D003433:Crosses, Genetic; D004260:DNA Repair / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000097642:GADD45 Proteins
D047908:Intracellular Signaling Peptides and Proteins; D000097642:GADD45 Proteins