Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-α in high-fat diet-induced obese rats.
OBJECTIVE
To investigate the effects of ethanolic extract of Lagenaria siceraria fruit (ELSF) on fat amassment and serum TNF- α in high-fat diet-induced obese rats.


METHODS
The high fat diet induced obese rats were orally treated with orlistat (50 mg/kg) and ELSF (100, 200, 300 mg/kg/day) to the respective treatment groups. The body weight, fasting blood glucose level, lipid profile, serum levels of tumor necrosis factor- α (TNF-α) in rats were measured after 30 days of treatment and compared to the obese control animals.


RESULTS
ELSF significantly (P < 0.001) reduced the body weight gain, fasting blood glucose, total cholesterol, triglyceride, total protein and TNF-α.


CONCLUSIONS
These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.
Technocarts Institute of Technology Pharmacy, Anand Nagar, Bhopal, Madhypradesh, India. snadeem_pharma@rediffmail.com
Sayyed
S
Nadeem
Pradeep
P
Dhore
Mohsin
M
Quazi
Sunil
S
Pawar
Navin
N
Raj
D000273:Adipose Tissue / Q000187:drug effects; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D019662:Cucurbitaceae; D059305:Diet, High-Fat / Q000379:methods; D005260:Female; D005638:Fruit; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D019440:Anti-Obesity Agents; D001786:Blood Glucose; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha