Positive predictive value of albumin: globulin ratio for feline infectious peritonitis in a mid-western referral hospital population.
Low albumin to globulin ratio has been found previously to have a high positive predictive value for feline infectious peritonitis (FIP) in cats with clinical signs highly suggestive of the disease. However, FIP can have a more vague clinical presentation. This retrospective study found that the positive predictive value of an albumin:globulin (A:G) ratio of <0.8 and <0.6 was only 12.5% and 25%, respectively, in a group of 100 cats with one or more clinical signs consistent with FIP. The negative predictive value was 100% and 99% for an A:G ratio of <0.8 and A:G<0.6%, respectively. Therefore, when the prevalence of FIP is low, the A:G ratio is useful to rule out FIP but is not helpful in making a positive diagnosis of FIP.
Department of Veterinary Pathology, Iowa State University, Ames, IA 50011, USA. ublocke@iastate.edu
Unity
U
Jeffery
Krysta
K
Deitz
Shannon
S
Hostetter
D000818:Animals; D002415:Cats; D016766:Feline Infectious Peritonitis / Q000175:diagnosis*; D005260:Female; D016013:Likelihood Functions; D008297:Male; D011237:Predictive Value of Tests; D012372:ROC Curve; D012017:Referral and Consultation; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis* / Q000378:metabolism; D012712:Serum Globulins / Q000032:analysis*; D014481:United States
D012709:Serum Albumin; D012712:Serum Globulins