[Effects of the effective components group of xiaoshuantongluo formula on rat acute blood stasis model].
Effects of the effective components group of Xiaoshuantongluo formula (XECG) on rat acute blood stasis model were studied under the guidance of the concept of effective components group. Rat acute blood stasis model was induced by subcutaneous injection of epinephrine combined with ice water bath. Hemorheology indices such as whole blood viscosity, plasma viscosity, erythrocyte aggregation index and platelet aggregation rate; coagulation parameters including PT, APTT, TT and FIB; 6-keto-PGF1alpha, TXB2 and D-dimer levels were determined to evaluate the effects of XECG. The results showed that XECG significantly reduced ADP-induced platelet aggregation, but showed little influence on the whole blood viscosity, plasma viscosity and erythrocyte aggregation rate. XECG extended PT and TT slightly, but had no effects on APTT and FIB content. D-dimer levels significantly decreased after administration of XECG with a little decrease of TXB2, but the content of 6-keto-PGF1alpha did not change significantly. The results suggest that the role of XECG of anti-aggregation is more prominent.
National Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yan
Y
Zhao
Xin
X
Yu
Li-Li
LL
Shi
Bai-Nian
BN
Chen
Shao-Hua
SH
Wang
Guan-Hua
GH
Du
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000097:blood*; D001809:Blood Viscosity / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D018056:Hemorheology / Q000187:drug effects; D008297:Male; D010314:Partial Thromboplastin Time; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D011517:Prothrombin Time; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013918:Thrombin Time; D013929:Thromboxane B2 / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha