Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.
Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Lalit Kumar
LK
Sharma
Na-Ra
NR
Lee
Eun Ryoung
ER
Jang
Beilei
B
Lei
Chang-Guo
CG
Zhan
Wooin
W
Lee
Kyung-Bo
KB
Kim
D001665:Binding Sites; D002460:Cell Line; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D008856:Microscopy, Fluorescence; D062105:Molecular Docking Simulation; D046988:Proteasome Endopeptidase Complex / Q000032:analysis* / Q000276:immunology; D040901:Proteomics / Q000379:methods
D005456:Fluorescent Dyes; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex