Distribution of fatty acids in adipose tissue of patients with type 2 diabetes.
BACKGROUND
It is not known whether alterations of adipose tissue fatty acid compositions predict type 2 diabetes. Our goal was to characterize the relationship between the adipose tissue fatty acid compositions and type 2 diabetes.


METHODS
We evaluated the fatty acid compositions of subcutaneous adipose tissue. These analyses were carried out on samples from 76 normal and 98 diabetic adults. Analysis was performed on a gas chromatograph.


RESULTS
The adipose tissue palmitic acid composition of diabetic subjects (24.9% +/- 0.3) was significantly higher (p = 0.01) than in the controls (23.3% +/- 1.6). A significant negative correlation (r = -0.276, p = 0.001) was found between adipose tissue polyunsaturated fatty acids (PUFAs) and the Chol/HDL-C ratio of all the subjects studied (controls plus diabetic patients). A similar negative correlation (r = -0.429, p = 0.001) was identified only for control group, whereas no significant correlation (p > 0.05) was found for diabetic populations. The correlation between fatty acid compositions and serum lipid profiles (TG, HDL-C, Chol/HDL-C, LDL-C/HDL-C proportion) and fasting blood sugar (FBS) with HbAlc concentrations of people with diabetes and controls was not significant.


CONCLUSIONS
A high amount of palmitic acid in adipose tissue may increase the risk of the type 2 diabetes and it seems that a high intake of PUFAs can lead to lowering of the Chol/HDL-C ratio.
Biochemistry Department of Medicine Faculty, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
Mohsen
M
Korani
Mohsen
M
Firoozrai
Jafar
J
Maleki
Faranak
F
Ghahramanpour
Iraj
I
Heidari
Soudabeh
S
Fallah
Morteza
M
Seifi
D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002849:Chromatography, Gas; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019308:Palmitic Acid / Q000378:metabolism; D050507:Subcutaneous Fat, Abdominal / Q000378:metabolism*
D001786:Blood Glucose; D008076:Cholesterol, HDL; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D019308:Palmitic Acid; D002784:Cholesterol