[The estimation of systemic chemotherapy treatment administered in breast cancer on lysozyme activity in tears--preliminary report].
OBJECTIVE
Estimation of cytostatics influence used in breast cancer treatment on lysozyme activity in human tears depend on time of treatment.


METHODS
8 women were treated at the base of chemotherapy schema: docetaxel with doxorubicin and 4 women treated with schema CMF: cyclophosphamide, methotrexate, 5-fluorouracil. Lysozyme activity in tears was assessed by measurement of diameter zone of Micrococcus lysodeicticus growth inhibition.


RESULTS
It was revealed that both chemotherapy schema caused statistically significant reduction of diameter zone of M. lysodeicticus growth inhibition, after first and second course of chemotherapy treatment. After second chemotherapy course CMF schema induced loss of lysozyme activity in patient's tears (zero mm of M. lysodeicticus diameter zone growth inhibition).


CONCLUSIONS
Systemic chemotherapy administered in breast cancer induce reduction of lysozyme activity in tears, that may cause higher morbidity of ocular surface infections caused by Gram-positive bacteria.
Klinika Okulistyki i Rehabilitacji Wzrokowej Uniwersytetu Medycznego w Łodzi. kasia2w@poczta.onet.pl
Katarzyna
K
Wojciechowska
Piotr
P
Jurowski
Marzena
M
Wieckowska-Szakiel
Barbara
B
Rózalska
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D004305:Dose-Response Relationship, Drug; D015818:Eye Infections, Bacterial / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009113:Muramidase / Q000187:drug effects*; D013666:Tears / Q000187:drug effects / Q000201:enzymology*
D009113:Muramidase