[Assessment of diastolic function in children and adolescents with type 1 diabetes mellitus - are there early signs of diabetic cardiomyopathy?].
OBJECTIVE
To evaluate diastolic function (DF) of children and adolescents with type 1 diabetes mellitus (DM1).


METHODS
Cross-sectional study of 67 otherwise healthy diabetic patients, and a control group (n = 84) in regard to age, sex, body mass index (BMI), Dopplere-chocardiography, and ECG for both groups; and disease duration, HbA1C, microalbuminuria, and serum lipids for DM 1 patients.


RESULTS
Diastolic alterations [(A and E mitral waves, E/A ratio, isovolumic relaxation time (IVRT) and E wave deceleration time (EWDT)] were found in diabetic patients, with higher prevalence among pubertal girls (13-17 years old). IVRT and EWDT correlated positively with BMI (p = 0.028). Chronological age and disease duration were predictive factors for mitral A wave (p = 0.004 and 0.033, respectively).


CONCLUSIONS
DF alterations were detected in the group of diabetic patients, with greater prevalence among pubertal girls; disease duration and age influenced parameters of DF.
Programa de Pós-graduação Saúde da Criança e do Adolescente, Universidade Federal do Paraná, Curitiba, PR, Brasil. cds_duarte@yahoo.com
Claudia Duarte
CD
Santos
Admar Moraes
AM
Souza
Rosana Marques
RM
Pereira
Margaret Cristina da Silva
MC
Boguszewski
Suzana Nesi
SN
França
Christopher Gallotti
CG
Vieira
Marcos
M
Furuta
Luiz de
Ld
Lacerda Filho
D000293:Adolescent; D000367:Age Factors; D000419:Albuminuria / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors