Refractory epileptic seizures due to vitamin B6 deficiency in a patient with Parkinson's disease under duodopa® therapy.
Levodopa/carbidopa intestinal gel (LCIG) infusion for the treatment of advanced Parkinson's disease (PD) has been suspected to provoke polyneuropathy in conjunction with vitamin B6, B12 and folate deficiency and elevated homocysteine levels. We describe a PD patient under LCIG therapy developing refractory epileptic seizures obviously promoted by vitamin B6 deficiency.
Department of Neurology, Knappschaftskrankenhaus, Hospital of the Ruhr-University Bochum, Bochum, Germany. sabine@skodda.de
Sabine
S
Skodda
Thomas
T
Müller
D000368:Aged; D002230:Carbidopa / Q000009:adverse effects* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D016896:Treatment Outcome; D025101:Vitamin B 6 / Q000627:therapeutic use; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced* / Q000188:drug therapy
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D025101:Vitamin B 6; D002230:Carbidopa