Cyclophilin A and viral infections.
Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc. However, recent studies demonstrated that CyPA also possesses a repressive effect on the replication of some viruses like Influenza A virus and rotavirus. Moreover, CyPA could also regulate host IFN-I response to viral infections. Together, these evidences showed diverse roles of CyPA in viral infection.
4th Team of Cadet Brigade, Third Military Medical University, Chongqing 400038, PR China.
Daijun
D
Zhou
Qiang
Q
Mei
Jintao
J
Li
Haiyang
H
He
D021984:Cyclophilin A / Q000235:genetics / Q000502:physiology*; D015658:HIV Infections / Q000201:enzymology / Q000276:immunology; D015497:HIV-1 / Q000502:physiology; D016174:Hepacivirus / Q000502:physiology; D006509:Hepatitis B / Q000201:enzymology / Q000276:immunology; D006515:Hepatitis B virus / Q000502:physiology; D006526:Hepatitis C / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000502:physiology; D007251:Influenza, Human / Q000201:enzymology / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology; D014777:Virus Diseases / Q000201:enzymology* / Q000276:immunology / Q000821:virology*; D014779:Virus Replication
D007370:Interferon Type I; D021984:Cyclophilin A