Chemical composition and antimicrobial activity of the leaf essential oil of Skimmia laureola growing wild in Jammu and Kashmir, India.
The analysis of Skimmia laureola hydrodistillate by gas chromatography coupled with mass spectrometry revealed the presence of 20 constituents, representing 94.6% of the total oil. The major constituents of oil were linalyl acetate (33.0%), linalool (25.0%), limonene (8.1%), α-terpineol (5.9%) and geranyl acetate (5.9%). The monoterpene (93.4%) rich essential oil was evaluated for its antibacterial and antifungal activities against seven microorganisms by agar diffusion and microdilution methods. The oil showed appreciable antimicrobial effects against all Gram-positive bacteria tested, including methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis with MIC values 32 and 64 µg mL(-1), respectively. The oil also exhibited strong fungicidal activity against Aspergillus niger and Penicillium chrysogenum with MIC value in the range 32-16 µg mL(-1). The oil could be used in the formulation of antimicrobial agents.
Department of Chemistry, University of Kashmir, Hazratbal Road, Srinagar 190006, Jammu and Kashmir, India.
Wajaht A
WA
Shah
Mohd Yousuf
MY
Dar
M Iqbal
MI
Zagar
Vijai K
VK
Agnihotri
M A
MA
Qurishi
Bikram
B
Singh
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D007194:India; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*
D000890:Anti-Infective Agents; D009822:Oils, Volatile