[Influence of new III class antiarrhythmic drug Niferidil (RG-2) on bioelectrical activity of rat pulmonary veins myocardium].
Myocardial cells in pulmonary veins are thought to play a major role in the initiation and maintenance of atrial arrhythmias, including atrial fibrillation. In experiments on rat pulmonary veins, antiarrhythmic drug niferidil (RG-2) produced increase of APD90% and functional refractory period and decrease of action potential amplitude and slope of APD restitution curve. Thus niferidil (RG-2) exerts stronger action on pulmonary veins than left atrium. This can take important part in Niferidil (RG-2) antiarrhythmic activity.
Iu V
IuV
Egorov
V I
VI
Stolbova
V S
VS
Kuz'min
L V
LV
Rozenshtraukh
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D016279:Atrial Function, Left / Q000187:drug effects*; D016280:Atrial Function, Right / Q000187:drug effects; D001682:Biological Availability; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000473:pathology; D011667:Pulmonary Veins / Q000473:pathology / Q000503:physiopathology*; D051381:Rats
D000889:Anti-Arrhythmia Agents