[Study of a new group of bioregulators isolated from the greater plantain (Plantago major L.)].
Proteins with physicochemical properties and biological activity similar to those of membrano-tropic homeostatic tissue-specific bioregulators that had been found earlier in various animal tissues were discovered in leaves of the common plantain (Plantago major L.). To study the specific activity of these plant proteins, we developed an experimental model for organotypic roller cultivation of newt (Pleurodeles waltl) skin tissue in vitro. We showed that the plant proteins of interest exert the wound-healing effect, which is characteristic of this plant, on the skin of vertebrates both in vitro and in vivo.
M S
MS
Krasnov
V P
VP
Iamskova
D V
DV
Margasiuk
O G
OG
Kulikova
A P
AP
Il'ina
E Iu
EIu
Rybakova
I A
IA
Iamslov
D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003470:Culture Media; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007525:Isoelectric Focusing; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010943:Plantago / Q000737:chemistry*; D012455:Salamandridae; D012867:Skin / Q000187:drug effects* / Q000293:injuries; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D046509:Tissue Culture Techniques; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
D001688:Biological Products; D003470:Culture Media; D010936:Plant Extracts; D010940:Plant Proteins