Effect of catalytic alkali metal bromide on Hofmann-type rearrangement of imides.
The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
Graduate School of Science, Chiba University, Chiba 263-8522, Japan. moriyama@faculty.chiba-u.jp
Katsuhiko
K
Moriyama
Kazuma
K
Ishida
Hideo
H
Togo
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003509:Cyclohexanecarboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D000077206:Gabapentin; D007094:Imides / Q000737:chemistry*; D008672:Metals, Alkali / Q000737:chemistry*; D010084:Oxidation-Reduction; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis / Q000737:chemistry
D000588:Amines; D001965:Bromides; D003509:Cyclohexanecarboxylic Acids; D007094:Imides; D008672:Metals, Alkali; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin