Epstein-Barr virus-associated smooth muscle tumour presenting as a parasagittal brain tumour.
Dural-based brain tumours, apart from meningiomas, are rare. Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is a documented but rare disease that occurs in immunocompromized patients. These tumours may be located at unusual sites including the brain. We present a 37-year-old patient, positive for the human immunodeficiency virus (HIV), who was admitted after generalized tonic-clonic seizures. MRI and CT scan revealed a dural-based brain tumour, intraoperatively thought to be a meningioma, but with an eventual histological diagnosis of EBV-SMT. Clinically the patient was well postoperatively with a Glasgow coma scale score of 15/15 and no focal neurologic deficit. This case confirms the association between EBV and SMT in patients with HIV/acquired immunodeficiency syndrome (AIDS). It also highlights the need to include EBV-SMT in the differential diagnosis of intracranial mass lesions in patients with HIV/AIDS.
Department of Neurosurgery, Wits Medical School, Chris Hani Baragwanath Academic Hospital, 7 York Road, Parktown, Johannesburg 2193, South Africa. ibebuikeke@yahoo.com
K E
KE
Ibebuike
S
S
Pather
O
O
Emereole
P
P
Ndolo
A
A
Kajee
R
R
Gopal
S
S
Naidoo
D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D003399:Craniotomy; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D015600:Glasgow Coma Scale; D015658:HIV Infections / Q000150:complications; D006679:HIV Seropositivity / Q000150:complications / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D019635:Neurosurgical Procedures; D018235:Smooth Muscle Tumor / Q000473:pathology* / Q000601:surgery; D054063:Superior Sagittal Sinus / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed