Aortic homograft endocarditis caused by Cardiobacterium hominis and complicated by agranulocytosis due to ceftriaxone.
The present report describes a very rare case of an aortic homograft valve endocarditis caused by Cardiobacterium hominis. The case was complicated by an agranulocytosis after 3 weeks of antibiotic treatment induced by ceftriaxone. Alternative oral treatment with ciprofloxacin and rifampicin was successful, no surgical intervention was needed and homograft function could be preserved.
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland. dominique.braun@usz.ch
Dominique
D
Braun
Arthur
A
Horovitz
Mihai
M
Bertea
Rolf
R
Jenni
Huldrych F
HF
Günthard
D000380:Agranulocytosis / Q000139:chemically induced* / Q000150:complications; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001021:Aortic Valve / Q000002:abnormalities* / Q000637:transplantation*; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000601:surgery*; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy; D001705:Bioprosthesis; D044066:Cardiobacterium; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy; D005500:Follow-Up Studies; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D006350:Heart Valve Prosthesis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D012008:Recurrence; D012086:Reoperation; D014184:Transplantation, Homologous
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone