[Clinical evaluation of a hyperferritinemia].
A hyperferritinemia has to be interpreted in relation with age and sex. The clinical evaluation begins with the interpretation of transferrine saturation which has to be controlled with a second fasting blood test. In case of high transferrine saturation associated with hyperferritinemia, HFE testing has first to be realized since the first diagnosis suspected is a HFE hemochromatosis. In case of normal transferrine saturation associated with a hyperferritinemia, the more frequent diagnosis is a metabolic syndrome, an inflammatory syndrome, a syndrome of cellular lysis or an excessive alcohol consumption. In case of HFE hemochromatosis, phlebotomy prevents complications. The goal is to obtain and to maintain a normal-low ferritin level. In case of metabolic syndrome, phlebotomy could be useful in case of high hepatic iron concentration measured with MRI or in case of on-alcoholic steato-hepatitis.
Assistance publique-Hôpitaux de Paris, hôpital Cochin, université Paris-Descartes, institut Cochin, CNRS (UMR 8104), Inserm U-1016, Sorbonne Paris Cité, service d'hépatologie, 75014 Paris, France. philippe.sogni@cch.aphp.fr
Philippe
P
Sogni
Catherine
C
Buffet
D000367:Age Factors; D005293:Ferritins / Q000097:blood*; D005838:Genotype; D006432:Hemochromatosis / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D019189:Iron Metabolism Disorders / Q000097:blood* / Q000209:etiology / Q000235:genetics; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000235:genetics; D012016:Reference Values; D012307:Risk Factors; D012737:Sex Factors; D014168:Transferrin / Q000378:metabolism
D014168:Transferrin; D005293:Ferritins