High-performance liquid chromatographic determination of triclosan and triclocarban in cosmetic products.
A high-performance liquid chromatographic (HPLC) method for the determination of triclosan and triclocarban in cosmetic products was developed. Triclosan and triclocarban quantities in 168 of cosmetics were investigated and statistical analyzed with this method. The optimal condition are as follows: An Agilent SB-C8 analytical column (250 × 4.6 mm, 5μm) was utilized, and mixed buffer solution of methanol and 0.01 mol L(-1) phosphate (pH 3.0) (72 : 28, V/V) were used for isocratic elution at a total flow rate of 1.0 mL min(-1) . It is found the calibration curves had a good linear regression with UV detection (280 nm) within test range of 0-110 μg mL(-1) with the correlation coefficients of 0.999 in all cases. This method is simple, selective, convenient, and reproducible for the determination of triclosan and triclocarban in commercial cosmetic products.
China National Cosmetics Quality Supervision & Inspection Center, Beijing, 100094, China.
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D002224:Carbanilides / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003358:Cosmetics / Q000737:chemistry*; D057230:Limit of Detection; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012044:Regression Analysis; D015203:Reproducibility of Results; D014260:Triclosan / Q000032:analysis*
D002224:Carbanilides; D003358:Cosmetics; D004364:Pharmaceutical Preparations; D014260:Triclosan; C009540:triclocarban