Preparation of concentrated colloids of gold core-silica shell nanoparticles for biomedical applications.
Encapsulation of gold nanoparticles within a silica shell is highly beneficial to the preparation of highly concentrated gold nanoparticles that can strongly absorb X-ray and hence be used as an X-ray contrast agent. This chapter describes a method for preparing highly concentrated colloidal gold nanoparticles suitable for an X-ray contrast agent application. It describes specific details of procedures for preparing spherical gold nanoparticles, forming thin silica shell on each gold nanoparticle, and enriching the silica-encapsulated gold nanoparticles.
FIRST Research Center for Innovative Nanobiodevices, Nagoya University, Nagoya, Japan. yspman@gmail.com
Yeon-Su
YS
Park
D000042:Absorption; D003102:Colloids; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*
D003102:Colloids; D006046:Gold; D012822:Silicon Dioxide