Correlation of hair mineral concentrations with insulin resistance in Korean males.
Calcium and magnesium that are associated with insulin resistance play an antagonistic role with each other in cells. This study was conducted to investigate the relationship between hair mineral concentrations and insulin resistance in Korean adult males. A total of 123 male subjects (63 patients with metabolic syndrome and 60 normal control patients) were recruited and fasting plasma glucose, total cholesterol, triglyceride, as well as HDL cholesterol levels, HOMA-IR, and hair mineral concentrations were measured. The ratio of calcium/magnesium in hair showed a significantly positive correlation with the HOMA-IR (r = 0.191, P = 0.038) and insulin (r = 0.198, P = 0.031). The result of multiple regression analysis after adjusting the age also showed a significant correlation of the Ca/Mg ratio with HOMA-IR (R² = 0.115, P = 0.047). The hair chromium concentration was lower in the metabolic syndrome group than in the control group, and it showed a significantly negative correlation with the fasting blood glucoseand the triglyceride. The result of this study showed that insulin resistance increased as the ratio of Ca/Mg increased, or as the chromium concentration in hair decreased.
Department of Family, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. juana@catholic.ac.kr
Ju-Hye
JH
Chung
Keun-Sang
KS
Yum
D000328:Adult; D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000032:analysis*; D002857:Chromium / Q000032:analysis* / Q000172:deficiency; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008274:Magnesium / Q000032:analysis*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D012044:Regression Analysis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D008903:Minerals; D014280:Triglycerides; D002857:Chromium; D008274:Magnesium; D002118:Calcium