Variability of the biological activity of oxidized titanium implants.
Oxidized titanium is a biologically inert material, but bioinertness reduces biomechanical characteristics of titanium implants. Modification of the structure of oxide surface layer of BT 5-1 titanium by increasing its thickness (by 1.7 times) and pore diameter (by 1.4 times) and by adding phosphorus, aluminum, and zinc oxides to its composition leads to radical modification of its biological characteristics. These implants acquire osteoinductive properties in in vivo systems not found in pure or oxidized BT 1-00 titanium and fairly well maintain in vitro growth of mesenchymal cells.
Department of Silicate and Nanomaterial Technology, National University of Resource-Effective Technologies, Tomsk Polytechnic University, Tomsk, Russia. vpshahov@mail.ru
V P
VP
Shakhov
V I
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Vereschagin
T S
TS
Petrovskaya
V P
VP
Ignatov
A V
AV
Krylatov
D000537:Aluminum Oxide / Q000737:chemistry; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000494:pharmacology*; D015921:Dental Implants; D062109:Dermatologic Surgical Procedures; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000502:physiology*; D017553:Phosphorus Compounds / Q000737:chemistry; D016062:Porosity; D012867:Skin / Q000187:drug effects / Q000648:ultrastructure; D040521:Subcutaneous Tissue / Q000187:drug effects / Q000601:surgery / Q000648:ultrastructure; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D015034:Zinc Oxide / Q000737:chemistry
D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017553:Phosphorus Compounds; C009495:titanium dioxide; D014025:Titanium; D000537:Aluminum Oxide; D015034:Zinc Oxide