Design, synthesis and antimicrobial properties of novel 3,3a,4,5,6,7- hexahydroindazole and arylthiazolylpyrazoline derivatives.
A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5  μg /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5  μg / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5  μg/ ml) and 3l (MIC 6.25 μg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.
Department of Chemistry, Lucknow University, University Road, Lucknow-226 007, India. abhabishnoi5@gmail.com
Abha
A
Bishnoi
Suruchi
S
Singh
Anil K
AK
Tiwari
Arun
A
Sethi
Chandrakant Mani
CM
Tripathi
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D015195:Drug Design; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007191:Indazoles; D011720:Pyrazoles; D013844:Thiazoles