Fabrication of TiO2 nanotubes on porous titanium scaffold and biocompatibility evaluation in vitro and in vivo.
Porous titanium was modified by anodic oxidation and heat treatment method. Scanning electron microscopy and X-ray diffraction examinations revealed that the modified surface of porous titanium was covered by anatase nanotubes. In vitro, the bioactivity of specimens before and after modification was evaluated by immersing into the double-concentration simulated body fluid for 7 days. The porous titanium specimens were implanted into the femurs of dogs for 3 months. The osteointegration of the implants was investigated by push-out test and histological examination. The results showed that the porous titanium with anatase nanotubes has the superior ability of apatite formation and a higher push-out force when compared with the other implants. The histological analysis indicated that the implant with anatase nanotubes had excellent ability to facilitate the osteointegration in vivo.
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Xingping
X
Fan
Bo
B
Feng
Zhiyuan
Z
Liu
Jing
J
Tan
Wei
W
Zhi
Xiong
X
Lu
Jianxin
J
Wang
Jie
J
Weng
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D004285:Dogs; D005269:Femur / Q000187:drug effects / Q000473:pathology; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena / Q000187:drug effects; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D019736:Prostheses and Implants; D013499:Surface Properties; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; C009495:titanium dioxide; D014025:Titanium