Cigarette smoke inhalation influences bone healing of post-extraction tooth socket: a histometric study in rats.
The aim of this study was to evaluate, histometrically, the bone healing of the molar extraction socket just after cigarette smoke inhalation (CSI). Forty male Wistar rats were randomly assigned to a test group (animals exposed to CSI, starting 3 days before teeth extraction and maintained until sacrifice; n=20) and a control group (animals never exposed to CSI; n=20). Second mandibular molars were bilaterally extracted and the animals (n=5/group/period) were sacrificed at 3, 7, 10 and 14 days after surgery. Digital images were analyzed according to the following histometric parameters: osteoid tissue (OT), remaining area (RA), mineralized tissue (MT) and non-mineralized tissue (NMT) in the molar socket. Intergroup analysis showed no significant differences at day 3 (p>0.05) for all parameters. On the 7(th) day, CSI affected negatively (p<0.05) bone formation with respect to NMT and RA (MT: 36%, NMT: 53%, RA: 12%; and MT: 39%, NMT: 29%, RA: 32%, for the control and test groups, respectively). In contrast, no statistically significant differences (p>0.05) were found at days 10 and 14. It may be concluded that CSI may affect socket healing from the early events involved in the healing process, which may be critical for the amount and quality of new-bone formation in smokers.
Department of Prosthodontics and Periodontics, Periodontics Division, Piracicaba Dental School, University of Campinas, SP, Brazil. anagetti@hotmail.com
Ana Paula Oliveira
AP
Giorgetti
João Batista
JB
César Neto
Márcio Zaffalon
MZ
Casati
Enílson Antonio
EA
Sallum
Francisco Humberto
FH
Nociti Júnior
D000704:Analysis of Variance; D000818:Animals; D001239:Inhalation; D008297:Male; D023421:Models, Animal; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D014028:Tobacco Smoke Pollution