Hypertension: management perspectives.
BACKGROUND
The increasing worldwide prevalence of hypertension and the related increase in cost due to diagnosis, management and negative outcomes forces public health institutions and clinical researchers to find new strategies to improve blood pressure (BP) control. So what are the possible future perspectives for high BP management?


METHODS
Three main points are briefly discussed in this article: individualized therapy, the known genetic contribution to hypertension development and control, and the improvement of disease management, including perspectives on new antihypertensive drug development.


CONCLUSIONS
It is likely that the integration of the best available current knowledge with recent diagnostic and therapeutic achievements for the management of hypertension prevention and treatment will lead to the early detection of at-risk conditions, early diagnosis, and individualized and efficacious treatment. The most promising antihypertensive drugs currently in development are innovative renin-angiotensin-aldosterone system modulators. Further drugs have potentially interesting mechanisms of action, but renalase analogs are in the very early phases of development, and available endothelin antagonists have a poor safety profile.
University of Bologna, Internal medicine, Aging and Kidney Diseases Department, Bologna, Italy. claudio.borghi@unibo.it
Claudio
C
Borghi
Arrigo F G
AF
Cicero
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control
D000959:Antihypertensive Agents