[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
OBJECTIVE
To study the anti-tumor effect of tanshinon II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines SUP-B15, K562, CEM, HL-60 and NB4.


METHODS
To study the anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, The leukemia cell lines were exposed to the six Chinese herbal components for 96 hours. The proliferative inhibitory effects were detected with MTT and described by IC50 value.


RESULTS
Tanshinone II A inhibited the proliferations of SUP-B15, K562, CEM, HL-60 and NB4 cell lines, with HL-60 showing the least impact. Tetrandrine, honokiol, curcumin and oridonin inhibited the proliferations of SUP-B15, K562, CEM, HL-60 and NB4 cell lines and there was no significant difference between the cell lines. Paeonol did not have significant inhibitory effect on leukemia cell lines.


CONCLUSIONS
Tetrandrine, honokiol, curcumin and oridonin inhibit the proliferation of five cell lines SUP-B15, K562, CEM, HL-60, NB4, and the effects are similar, which means that their anticancer effects are quite broad. Tanshinone II A has better anti-leukemia effects on SUP-B15, K562, CEM, NB4 than on HL-60. The effect of paeonol against leukemia cell lines is poor.
Department of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Qing-qing
QQ
Shan
Yu-ping
YP
Gong
Yong
Y
Guo
Juan
J
Lin
Rui-qing
RQ
Zhou
Xi
X
Yang
D045784:Abietanes / Q000494:pharmacology; D000098:Acetophenones / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D044182:Benzylisoquinolines / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000473:pathology*; D017705:Lignans / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D000498:Allyl Compounds; D010636:Phenols
D045784:Abietanes; D000098:Acetophenones; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; D001713:Biphenyl Compounds; D003474:Curcumin; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; D017705:Lignans; C021751:tanshinone; C011959:oridonin; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C009438:tetrandrine; C013638:paeonol