Isolation and neuroprotective activities of acylated iridoids from Valeriana jatamansi.
Three new iridoids, jatairidoids A-C (1-3, resp.), have been isolated from the roots of Valeriana jatamansi (V. wallichii). Their structures were elucidated by spectroscopic methods (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR). Compounds 1 and 2 are C(3)-epimers. The three compounds were evaluated for their neuroprotective effects against MPP(+)-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. All the isolates exhibited moderate neuroprotective effects.
College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, PR China.
Jing
J
Xu
Yuanqiang
Y
Guo
Chunfeng
C
Xie
Da-Qing
DQ
Jin
Jie
J
Gao
Liping
L
Gui
D000215:Acylation; D059290:Dopaminergic Neurons / Q000187:drug effects*; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D009447:Neuroblastoma; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014632:Valerian / Q000737:chemistry*
D039823:Iridoids; D018696:Neuroprotective Agents; D010936:Plant Extracts