Experimental study of the effects of metal nanoparticles on tumor growth and bone marrow hemopoiesis.
Metal (Zn, Cu, Fe) nanoparticles, particularly Zn, induce regression of transplanted sarcoma 37 and increase the percentage of dead and degenerated cells. Antitumor effect of metal nanoparticles was not associated with leukopenia or coarse bone marrow abnormalities, but differential leukocyte and bone marrow counts remained changed.
Rostov Oncological Institute, Federal Agency for High Technological Medical Care, Russia. rnioi@list.ru
E Yu
EY
Zlatnik
L V
LV
Peredreyeva
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D051379:Mice; D012511:Sarcoma 37 / Q000188:drug therapy
D000970:Antineoplastic Agents