[Clinicalpathological characteristics of Lynch syndrome related epithelial ovarian cancer].
OBJECTIVE
To explore the clinical pathological characteristics of Lynch syndrome associated ovarian cancer.


METHODS
Totally 260 cases ovarian cancer patients were admitted to Tianjin Medical University General Hospital during Jan. 2004 and Jan. 2011, among which 10 patients (LS group) belonged to Lynch syndrome associated ovarian cancer according to Amsterdam II criteria. One hundred ovarian cancer patients without any family cancer history were enrolled randomizely as control group (sporadic group).


RESULTS
Lynch syndrome associated ovarian cancer accounted for 3.8% (10/260), the incidence rate of ovarian cancer for female family members of Lynch syndrome was 8.7% (10/115). Mean age at time of diagnosis in LS group was (46 ± 7) years, significantly earlier than that in sporadic group [(56 ± 11) years, P < 0.05]. There was no statistical difference between two groups in histological type or International Federation of Gynecology and Obstetrics (FIGO) stage (P > 0.05). Most of the tissue differentiation in LS group were well or moderate differentiated, there was statistical difference between the two groups (9/10 vs. 55%, P < 0.05). The 3-year and 5-year survival rate in LS group were 87.5% and 52.5% respectively, compared with 55.4%and 22.7% in sporadic group (all P < 0.05).


CONCLUSIONS
Compared with sporadic ovarian cancer, Lynch syndrome associated ovarian cancer is more likely present as the clinical pathological characteristics of early age of onset, serous adenocarcinoma, lower grade and better prognosis.
Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China.
Xue-gong
XG
Ma
Ying-mei
YM
Wang
Feng-xia
FX
Xue
Hui-ying
HY
Zhang
Hong-na
HN
Sheng
Zheng
Z
Qi
Guo-yan
GY
Liu
D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D000077216:Carcinoma, Ovarian Epithelial; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D018284:Cystadenocarcinoma, Serous / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D010375:Pedigree; D011379:Prognosis; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D015996:Survival Rate