Seizures in acute stroke: incidence, risk factors and prognosis.
OBJECTIVE
Studies on post-stroke seizures have produced conflicting results. Our study aim was to further elucidate the incidence and predictive factors of early post-stroke seizures (ES) and their relationship with outcome.


METHODS
relevant clinical data were prospectively collected in 2,053 patients with acute stroke admitted to the Stroke Unit from 2004 to 2008.


RESULTS
Sixty-six patients (8 hemorrhagic and 58 ischemic strokes) aged 73-88 years (mean age 82 years) presented seizures in the first week after stroke onset. The type of ischemic stroke was atherothrombotic in 10 patients, cardioembolic in 21, lacunar in 4, undetermined in 19, and of other etiology in 4. Twenty-seven patients had generalized convulsive, 6 had complex partial, and 33 had simple partial seizures. Status epilepticus was observed in 13 patients. The severity of strokes in patients with ES was greater than in those without (National Institutes of Health Stroke Scale >14 in 50 vs. 25%), so mortality (30 days) was higher (29 vs. 14%). Independent seizure predictors were: total anterior circulation infarct, hemorrhagic transformation, hyperglycemia, and the interaction term diabetes × hyperglycemia.


CONCLUSIONS
ES may be considered a marker of stroke severity. Cortical location of the lesion, hemorrhagic transformation, and hyperglycemia in patients without diabetes are important predictors of ES.
Neurologia-Stroke Unit, Ospedale Maggiore, IRCCS, Istituto di Scienze neurologiche, Bologna, Italy. gaetano.procaccianti@ausl.bo.it
Gaetano
G
Procaccianti
Anna
A
Zaniboni
Francesca
F
Rondelli
Michela
M
Crisci
Tommaso
T
Sacquegna
D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000453:epidemiology; D002545:Brain Ischemia / Q000453:epidemiology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D015994:Incidence; D020300:Intracranial Hemorrhages / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology* / Q000209:etiology; D020521:Stroke / Q000150:complications / Q000453:epidemiology*