Prolidase and oxidative stress in chronic hepatitis C.
BACKGROUND
Hepatitis C infection represents a common healthcare issue worldwide. The present trial was designed to investigate the role of prolidase, an enzyme that is significantly involved in the biosynthesis of collagen, and of the oxidative stress that is considered to be involved in the pathogenesis of various diseases, in the chronic hepatitis C infection. The trial was performed to assess the serum prolidase enzyme level and the oxidative-antioxidative status and to determine the relation between the serum prolidase activity and the oxidative stress parameters.


METHODS
A total of 95 individuals, including 55 patients with chronic hepatitis C infection (CHC) and 40 healthy adults, were enrolled in the trial. The values for prolidase, the total antioxidant status (TAS), the total oxidative stress (TOS), the oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation LOOH, catalase (CAT), and ceruloplasmin were measured and compared between the patient groups.


RESULTS
The prolidase, TOS, LOOH, CAT, and the OSI values were higher in the chronic hepatitis C group compared to the control group (P < 0.001). The TAS, SH, and ceruloplasmin levels were lower in the CHC group relative to the control group (P < 0.001).


CONCLUSIONS
We suppose that the values of prolidase and the oxidative stress are increased while the antioxidant levels are decreased in CHC. As a result, prolidase and the oxidative stress seem to be related with the progression of the disease.
Department of Infectious Diseases and Clinical Microbiology, Tokat State Hospital, Tokat, Turkey. drfduygu@yahoo.com
Fazilet
F
Duygu
Suda Tekin
ST
Koruk
Hasan
H
Karsen
Nurten
N
Aksoy
Abdullah
A
Taskin
Melek
M
Hamidanoglu
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004150:Dipeptidases / Q000097:blood* / Q000378:metabolism; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D018709:Statistics, Nonparametric; D013438:Sulfhydryl Compounds / Q000097:blood
D013438:Sulfhydryl Compounds; D002374:Catalase; D004150:Dipeptidases; C022449:proline dipeptidase