Effect of hypoxia on the state of tissues in SAMR1 and SAMP1 mice with various rates of aging.
Senescence-accelerated SAMP1 mice were more sensitive to the negative effect of hypobaric hypoxia than SAMR1 mice (control). Low-temperature EPR spectroscopy showed that high sensitivity of SAMP1 mice is related to the increased concentration of methemoglobin in the blood leading to hemic hypoxia. Proton magnetic relaxation study showed that the exposure of SAMP1 mice to hypoxia can cause cerebral edema.
Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. mgm52@bk.ru
M G
MG
Makletsova
G T
GT
Rihireva
S L
SL
Stvolinsky
V L
VL
Sharygin
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D000860:Hypoxia / Q000503:physiopathology*; D008565:Membrane Proteins / Q000235:genetics; D008706:Methemoglobin / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D009687:Nuclear Proteins / Q000235:genetics; D018384:Oxidative Stress / Q000502:physiology*
D008565:Membrane Proteins; D009687:Nuclear Proteins; C575109:Samp1 protein, mouse; D008706:Methemoglobin