High density lipoprotein is positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment.
OBJECTIVE
The investigation of the relationship between high density lipoprotein (HDL) and adiponectin.


METHODS
Thirty-seven obese or overweight [body mass index ≥27 Kg/m(2)], hypertriglyceridemic patients underwent one of the following interventions for 3 months: 1) Low-calorie diet (n=19), 2) Low-calorie diet plus fenofibrate (n=18).


RESULTS
Circulating total adiponectin did not change significantly in the low-calorie diet group. However, in the subgroup of patients whose high density lipoprotein cholesterol (HDL-C) decreased over the first month of diet, a statistically significant reduction of the circulating total adiponectin was observed (p=0.010), while in the subgroup of patients whose HDL-C increased over the latter 2 months of the diet, an increase in circulating total adiponectin over the 2 months was found (p=0.043). The percentage change of HDL-C over the first month of diet was positively correlated with the percentage change of circulating total adiponectin (r=0.579, p=0.019). The percentage change of HDL-C over the 3 months of diet was positively correlated with the percentage changes of circulating total adiponectin (r=0.527, p=0.030) and high molecular weight (HMW) adiponectin (r=0.524, p=0.031). The change in circulating total adiponectin over the first month of diet was positively correlated with the HDL-C at 1 month (r=0.606, p=0.013). The change in HMW adiponectin over the 3 months of diet was positively correlated with the HDL-C at 3 months (r=0.602, p=0.011). The percentage change of circulating HMW adiponectin over the first month of fenofibrate treatment was positively correlated with the percentage change of HDL-C (r=0.594, p=0.012).


CONCLUSIONS
HDL is positively correlated with the changes in circulating adiponectin during dietary and fenofibrate treatment.
Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
Georgios A
GA
Christou
Konstantinos C
KC
Tellis
Moses C
MC
Elisaf
Alexandros D
AD
Tselepis
Dimitrios N
DN
Kiortsis
D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000378:metabolism*; D004032:Diet; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015228:Hypertriglyceridemia; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D052242:Adiponectin; D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D011345:Fenofibrate