Effect of transplantation of bone marrow monomuclears on angiogenesis in rats.
We studied the effect of non-selective intracoronary transplantation of bone marrow mononuclears on day 30 after acute coronary infarction on angiogenesis in rats. On days 14 and 30 after transplantation of mononuclear cells, stable formation of new vessels was observed. The number of venules considerably increased after transplantation of mononuclear cells, which was seen from increased volume density of blood vessels and their caliber. Stable vascularization after transplantation of mononuclear cells improves blood supply, which is essential for reparation of the myocardium.
Laboratory of Growth and Development, Research Institute of Human Morphology, Russian Academy of Medical Sciences, Russian State Medical University, Moscow, Russia. fatkhudinov@gmail.com
T Kh
TKh
Fatkhudinov
J P
JP
Baikova
G B
GB
Bolshakova
T B
TB
Buharova
T K
TK
Dubovaya
L V
LV
Kaktursky
D V
DV
Goldshtein
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D016026:Bone Marrow Transplantation; D002921:Cicatrix / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D006097:Granulation Tissue / Q000098:blood supply; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D018919:Neovascularization, Physiologic; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration; D014699:Venules / Q000503:physiopathology