Rhabdomyolysis with acute renal failure triggered by the seasonal flu vaccination in a patient taking simvastatin.
A man in his 70s presented with bilateral, painful legs and feeling generally unwell following the seasonal flu vaccination. The patient had a background of B cell lymphoma in partial remission. His current medications included simvastatin. Initial investigations revealed rhabdomyolysis and acute renal failure. He was admitted to critical care for renal replacement treatment. Other causes of rhabdomyolysis were excluded and expert opinion agreed that the most likely cause was the influenza vaccination with the concurrent use of simvastatin. The patient's renal function gradually normalised and after several months the patient has regained full power in his legs.
Intensive Care Department, University Hospital Lewisham, London, UK. sneh.shah@doctors.net.uk
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SV
Shah
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Reddy
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016638:Critical Illness / Q000628:therapy; D005500:Follow-Up Studies; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D007251:Influenza, Human / Q000469:parasitology; D007362:Intensive Care Units; D007677:Kidney Function Tests; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D018570:Risk Assessment; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome; D014611:Vaccination / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D007252:Influenza Vaccines; D019821:Simvastatin; D003404:Creatinine