[Annexin A5 gene polymorphism (-1C/T) and the susceptibility to pneumoconiosis in coal works].
OBJECTIVE
To explore the role of -1C/T single nucleotide polymorphism within Annexin A5 gene in the genetic susceptibility to coal worker's pneumoconiosis (CWP).


METHODS
Four hundred and seventy CWP Han chinese patients and 428 Han chinese controls were enclosed in present case-control study. All subjects were exposed to coal dusts. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the -1C/T SNP in Annexin A5 gene for all subjects. The relationship between the -1C/T SNP in Annexin A5 gene and CWP was analyzed.


RESULTS
CT/TT genotype in -1C/T SNP was associated with a significantly decreased risk of CWP, as compared with the CC genotype among subgroups exposed to coal dusts for ≥ 27 years (adjusted OR = 0.65, 95%CI: 0.44 - 0.98, P = 0.039) and patients with CWP at stage II (adjusted OR = 0.55, 95%CI: 0.34 - 0.90, P = 0.028).


CONCLUSIONS
The results of present study suggest that the Annexin A5 -1C/T polymorphism may be involved in the development of CWP in Han Chinese coal miners.
Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Ting
T
Wang
Sha-sha
SS
Wang
Zhi-Guo
ZG
Hou
Xiao-Ming
XM
Ji
Zhi-Fang
ZF
Song
Xiao-Min
XM
Jia
Mei-Lin
ML
Wang
Chun-Hui
CH
Ni
D000368:Aged; D017304:Annexin A5 / Q000235:genetics*; D055008:Anthracosis / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D017304:Annexin A5