DLC-1 expression levels in breast cancer assessed by qRT- PCR are negatively associated with malignancy.
OBJECTIVE
The aim of this study was to explore the expression of DLC-l in breast carcinoma and any association with tumor metastasis.


METHODS
51 surgical specimens of human breast carcinoma, divided into high invasive and low invasive groups according to their clinicopathological features, 30 cases of adjacent normal tissue and 28 benign breast lesions were examined by qRT-PCR for expression of DLC-1.


RESULTS
Expression level of DLC-1 in adjacent normal tissue and benign breast lesion specimens was higher than that in breast carcinoma (P<0.0001); the values in the high invasive group with synchronous metastases were also lower than in the low invasive group (P=0.0275). The correlation between DLC-1 expression level and tumor progression and metastasis of breast cancer was negative.


CONCLUSIONS
As an anti-oncogene, DLC-1 could play an important part in breast carcinoma occurrence, progression, invasiveness and metastasis. Detecting the changes of the expression of DLC-1 in the breast carcinoma may contribute to earlier auxiliary diagnosis of invasiveness, metastasis and recrudescence.
Department of Oncology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, China. chengnongguancn@163.com
Cheng-Nong
CN
Guan
Pei-Wen
PW
Zhang
Hai-Qing
HQ
Lou
Xiang-Hui
XH
Liao
Bao-Ying
BY
Chen
D001940:Breast / Q000378:metabolism; D001941:Breast Diseases / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D018709:Statistics, Nonparametric; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
C112352:DLC1 protein, human; D020690:GTPase-Activating Proteins; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins