The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment.
The study analyzed the effect of dopamine 2 receptor gene (DRD2) polymorphism on the risk for major depressive disorder (MDD) and the response to selective serotonin reuptake inhibitors (SSRIs). The results suggest that the DRD2 gene may play a role on MDD susceptibility and the onset-time of antidepressant response.
The Psychiatric Laboratory & the Department of Psychiatry, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Yingcheng
Y
Wang
Xiang
X
Liu
Yue
Y
Yu
Yuanyuan
Y
Han
Jinxue
J
Wei
David
D
Collier
Tao
T
Li
Xiaohong
X
Ma
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
D000928:Antidepressive Agents; D017448:Receptors, Dopamine D2; D017367:Selective Serotonin Reuptake Inhibitors