Serum CA19-9 level associated with metabolic control and pancreatic beta cell function in diabetic patients.
CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.
School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, China.
Haoyong
H
Yu
Ruixia
R
Li
Lei
L
Zhang
Haibing
H
Chen
Yuqian
Y
Bao
Weiping
W
Jia
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D018395:CA-19-9 Antigen / Q000097:blood*; D016022:Case-Control Studies; D002784:Cholesterol / Q000378:metabolism; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D007515:Islets of Langerhans / Q000166:cytology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
D001786:Blood Glucose; D018395:CA-19-9 Antigen; D002784:Cholesterol