Anaphylaxis due to intravenous levofloxacin with tolerance to garenoxacin.
Fluoroquinolones are widely used in the management of infectious diseases, and are generally safe and well tolerated. However, immediate hypersensitivity reactions, including anaphylactic reactions, have been reported. We present here a case of anaphylactic shock in a 26-year-old man following intravenous levofloxacin administration. Skin tests confirmed an immediate hypersensitivity reaction to levofloxacin. Subsequent oral challenge tests for garenoxacin, which showed negative skin test results, confirmed that garenoxacin was well tolerated. This is the first report of tolerance to full-dose garenoxacin in a patient who developed an immediate hypersensitivity reaction to levofloxacin.
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan. kiyoharufukushima@hotmail.co.jp
Kiyoharu
K
Fukushima
Michiko
M
Nakatsubo
Masahiro
M
Noda
Takeshi
T
Uenami
Yoshitomo
Y
Hayama
Naotoshi
N
Tsuruta
Shuntaro
S
Oniki
Yoshiyuki
Y
Saito
Takashi
T
Niju
Toshiyuki
T
Ikeda
D000328:Adult; D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy; D012882:Skin Tests
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D064704:Levofloxacin; D015242:Ofloxacin; C419689:garenoxacin