Morphofunctional evaluation of the effect of transplantation of allogeneic fibroblasts on healing of burn wounds in albino outbred mice and mutant Hr(hr)/Hr(hr) mice.
Morphofunctional evaluation of the effect of transplantation of allogeneic fibroblasts on skin regeneration after burn injury in albino outbred mice and mutant Hr(hr)/Hr(hr) (nude) mice was carried out using the radioautographic method. The pronounced stimulating effect of allogeneic fibroblasts on healing of burn wound observed in mice of both groups can be attributed to the action of bioactive substances released from destructed allogeneic fibroblasts and stimulating proliferation of stem/progenitor cells in the wound (epithelial cells in skin appendages and dermal cells in microvessel walls) at the early stages of healing.
N. V. Sklifosovskii Institute of Emergency Medical Care; N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. kolokol_eg@mail.ru
E G
EG
Kolokolchikova
E A
EA
Zhirkova
P K
PK
Golovatenko-Abramov
E S
ES
Platonov
S V
SV
Smirnov
V S
VS
Botcharova
D000818:Animals; D001345:Autoradiography; D002056:Burns / Q000473:pathology / Q000628:therapy*; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology / Q000637:transplantation; D051379:Mice; D008812:Mice, Hairless; D008853:Microscopy; D055806:Microvessels / Q000166:cytology / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D012867:Skin / Q000293:injuries / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014184:Transplantation, Homologous; D014945:Wound Healing