Comparative evaluation of the efficiency of various alginate forms under conditions of an oncological experiment.
The effects of various alginate forms on the development of transplanted tumors in mice and efficiency of cytostatic therapy were studied. High-molecular-weight Ca and Na alginates, acid-soluble hydrolysate, and sodium alginate fraction inhibited the growth of Ehrlich adenocarcinoma. The use of acid-insoluble sodium alginate in chemotherapy protocol improved the treatment efficiency. All alginate forms inhibited metastasizing of Lewis pulmonary carcinoma; in combination with cyclophosphamide they potentiated its antimetastatic effect.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
T G
TG
Razina
O Yu
OY
Rybalkina
K A
KA
Lopatina
E N
EN
Amosova
E P
EP
Zueva
M Yu
MY
Khotimchenko
Yu S
YS
Khotimchenko
D000464:Alginates / Q000627:therapeutic use*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D005260:Female; D020723:Glucuronic Acid / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000627:therapeutic use; D008297:Male; D009368:Neoplasm Transplantation
D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid