Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application.
Antimicrobial peptides (AMPs), which are produced by several species including insects, other animals, micro-organisms and synthesis, are a critical component of the natural defense system. With the growing problem of pathogenic organisms resistant to conventional antibiotics, especially with the emergence of NDM-1, there is increased interest in the pharmacological application of AMPs. They can protect against a broad array of infectious agents, such as bacteria, fungi, parasite, virus and cancer cells. AMPs have a very good future in the application in pharmaceuticals industry and food additive. This review focuses on the AMPs from different origins in these recent years, and discusses their various functions and relative mechanisms of action. It will provide some detailed files for clinical research of pharmaceuticals industry and food additive in application.
Biopharmaceutical Research and Development Center, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
Yanmei
Y
Li
Qi
Q
Xiang
Qihao
Q
Zhang
Yadong
Y
Huang
Zhijian
Z
Su
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D004345:Drug Industry; D005503:Food Additives; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010271:Parasites / Q000187:drug effects; D014780:Viruses / Q000187:drug effects
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005503:Food Additives