Relationship between depression in patients with COPD and the percent of predicted FEV(1), BODE index, and health-related quality of life.
BACKGROUND
We investigated the prevalence of depression among patients with COPD treated in long-term in-patient rehabilitation facilities, using the Center for Epidemiologic Studies Depression scale (CES-D). Furthermore, the relationship between the severity of air-flow obstruction (the percent of predicted FEV(1)), BODE (body mass index, degree of air-flow obstruction, dyspnea, exercise capacity) index, health-related quality of life (St George's Respiratory Questionnaire [SGRQ]), and depression were investigated.


METHODS
We recruited 74 in-patients (64 males, 10 females) with COPD. The mean age of the subjects was 72.7 years (range 52-85 y). Subjects completed the CES-D, and measurements were made of pulmonary function, body mass index, Modified Medical Research Council dyspnea scale, 6-min walk test (6MWT), and SGRQ.


RESULTS
Depression was evident in 48.6% (n = 36) of the subjects. A weak correlation was found between the CES-D scores and the percent of predicted FEV(1). The prevalence of depression showed a significant association with BODE stage. Scores for the SGRQ activity and impacts domains, and total SGRQ score were significantly worse in the subjects who were depressed.


CONCLUSIONS
We found a high prevalence of depression among patients with stable COPD treated in long-term in-patient rehabilitation facilities. Depression among these patients, as measured by the CES-D, was associated with greater impairment in respiratory function and with poorer Modified Medical Research Council dyspnea scale and SGRQ scores. The prevalence of depression increased with BODE stage.
Course of Health Sciences, Department of Neuropsychiatry, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Asuka
A
Iguchi
Hideaki
H
Senjyu
Yoshika
Y
Hayashi
Rumi
R
Kanada
Shoko
S
Iwai
Sumihisa
S
Honda
Chika
C
Kitagawa
Hiroki
H
Ozawa
Naoto
N
Rikitomi
D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003863:Depression / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D004417:Dyspnea / Q000150:complications; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires