Factors associated with post-pancreaticoduodenectomy hemorrhage: 303 consecutive cases analysis.
BACKGROUND
Because of the complexity and severity of the surgery and its associated complications, pancreaticoduodenectomy (PD) is associated with significant morbidity and mortality, especially the hemorrhage post-PD. Exploring the factors associated with post-PD hemorrhage is very important for the patients' safety.


METHODS
Clinical data from 303 cases of PD between January 1998 and December 2008 were analyzed retrospectively.


RESULTS
The overall mortality rate was 4.95% (15/303). However, post-operative bleeding occurred in 25 patients (8.25%) with nine episodes resulting in death (36.00%). Univariate analysis was performed and identified tumor size, Child's classification, total pancreatic uncinatic process resection, and pancreatic leakage as significant risk factors for post-PD hemorrhage. In the severe hemorrhage group, incomplete resection of uncinate process of pancreas and pancreatic leakage were the main causes. The multivariate Logistic regression analysis revealed that each of these variables is an independent risk factor.


CONCLUSIONS
Primary prevention of bleeding complications depends on total pancreatic uncinatic process resection and meticulous hemostatic techniques during surgery. In addition, several peri-operative factors were found to contribute to post-PD bleeding.
Department of Surgery, Peking University First Hospital, Beijing 100034, China.
Qing-Xiang
QX
Gao
Hua-Yu
HY
Lee
Wen-Han
WH
Wu
Song
S
Gao
Yin-Mo
YM
Yang
Irene Teting
IT
Ma
Meng-Shan
MS
Cai
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000401:mortality; D019106:Postoperative Hemorrhage / Q000209:etiology*; D012307:Risk Factors