Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide.
The effect of a low dose of the insecticide permethrin administered during early-life was evaluated on leukocytes inflammation mediators on 300- and 500-day-old rats. Nurr1, NF-κB-p65, Nrf2, lipid peroxidation and GSH levels increased with age but compared to the control group, treatment with permethrin induced a significant increase only of Nurr1 and lipid peroxidation in oldest rats. TNF-α and Rantes increased, while IL-1β, IL-2, IL-13 decreased in oldest treated rats. The results propose Nurr1, TNF-α, Rantes, GSH and plasma lipid peroxidation as peripheral biomarkers for monitoring the impact of early-life environmental exposure to xenobiotics in old age.
School of Pharmacy and School of Biosciences and Biotechnology, University of Camerino, Italy.
Donatella
D
Fedeli
Maura
M
Montani
Manuel
M
Carloni
Cinzia
C
Nasuti
Augusto
A
Amici
Rosita
R
Gabbianelli
D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D004781:Environmental Exposure; D005260:Female; D005978:Glutathione / Q000097:blood; D007306:Insecticides / Q000633:toxicity*; D007962:Leukocytes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2 / Q000378:metabolism*; D026023:Permethrin / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D051996:Transcription Factor RelA / Q000378:metabolism
D015415:Biomarkers; D016207:Cytokines; D007306:Insecticides; D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; C539884:Nr4a2 protein, rat; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; C498145:Rela protein, rat; D051996:Transcription Factor RelA; D026023:Permethrin; D013482:Superoxide Dismutase; D005978:Glutathione