POEMS syndrome - a unique presentation of a rare paraneoplastic syndrome.
POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder. A 40-year-old male with a history of peripheral neuropathy and erectile dysfunction presented with a pathological fracture of the neck of the femur, found to be a solitary plasmacytoma. Additional unusual features included splenomegaly, hyperprolactinaemia and skin changes. The patient had a total hip replacement at a specialist orthopaedic hospital and is due to undergo radiotherapy to the femoral lesion and autologous stem cell transplantation.
Accident and Emergency Department, Basildon and Thurrock University Hospital, Nethermayne, Essex, UK. judithlivingston@hotmail.co.uk
J
J
Livingston
C
C
Cobiella
M A
MA
Hall-Craggs
D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D003131:Combined Modality Therapy; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005598:Fractures, Spontaneous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006620:Hip Fractures / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D016878:POEMS Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010954:Plasmacytoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D035583:Rare Diseases