[Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots].
OBJECTIVE
To study chemical constituents from the roots of Saussurea lappa.


METHODS
Chemical constituents were separated and purified by various techniques such as silica gel column chromatography, Sephadex LH-20 and reversed phase RP-18 column chromatography. Their structures were identified on the basis of spectral data.


RESULTS
Seventeen compounds were separated and identified as ascleposide E(1), (+)-1-hydroxypinoresinol-4"-O-methyl ester-4'-beta-D-glucopyranoside (2), (+)-1 -hydroxypinoresinol-4"-O-beta-D-glucopyranoside(3), (+)-1-hydroxypinoresinol-1-O-P-D-glucopyranoside (4), phenyl-beta-D-glucopyranoside (5), benzyl-beta-D-glucopyranoside (6), n-butyl-beta-D-glucopyranoside (7), ilicic alcohol (8), beta-cyclocostunolide (9), reynosin (10), 11beta, 13-dihydroreynosin (11), arbusculin A(12), 1beta-hydroxy-arbusculin A (13), santamarin (14), dehydrocostuslactone (15), 11beta, 13-dihydro-3-epizaluzanin C(16)and costunolide (17).


CONCLUSIONS
Compounds 1-2 were separated from this genus for the first time,and compounds 3,5-7 were separated from this plant for the first time.
State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beling 100050, China.
Ting
T
Zhang
Lin
L
Ma
Feng
F
Wu
Ruoyun
R
Chen
D000431:Ethanol / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D030441:Saussurea / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry
D005960:Glucosides; D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C016722:santamarine; C065894:dihydroreynosin; D000431:Ethanol; C083030:dehydrocostus lactone; C002602:costunolide