[Progress in relationship between heritable hypercoagulable state and avascular necrosis of femoral head].
OBJECTIVE
To review the relationship between heritable hypercoagulable state (HHCS) and avascular necrosis of femoral head (ANFH).


METHODS
The latest original articles about the relationship between HHCS and ANFH were extensively reviewed.


RESULTS
Several genetic mutations which could cause HHCS, such as thrombophilic factor V G1691A gene, thrombophilic factor II G20210A gene, 5, 10-methylenetetrahydrofolate reductase C677T gene, plasminogen activator inhibitor 1 4G/5G, and tissue factor pathway inhibitor gene, may be genetic risks of ANFH.


CONCLUSIONS
HHCS may be a genetic cause of ANFH. Further studies are needed to confirm the relationship between HHCS and Chinese ANFH.
Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China.
Wenjing
W
Yin
Jiagen
J
Sheng
D005165:Factor V / Q000235:genetics*; D005271:Femur Head Necrosis / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000235:genetics*
D017395:Plasminogen Activator Inhibitor 1; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)