Prediction of retinopathy of prematurity using the screening algorithm WINROP in a Mexican population of preterm infants.
OBJECTIVE
To retrospectively validate the WINROP (weight, insulin-like growth factor I, neonatal, retinopathy of prematurity [ROP]) algorithm in identification of type 1 ROP in a Mexican population of preterm infants.


METHODS
In infants admitted to the neonatal intensive care unit at Hospital Civil de Guadalajara from 2005 to 2010, weight measurements had been recorded once weekly for 192 very preterm infants (gestational age [GA] <32 weeks) and for 160 moderately preterm infants (GA ≥32 weeks). Repeated eye examinations had been performed and maximal ROP stage had been recorded. Data are part of a case-control database for severe ROP risk factors.


RESULTS
Type 1 ROP was found in 51.0% of very preterm and 35.6% of moderately preterm infants. The WINROP algorithm correctly identified type 1 ROP in 84.7% of very preterm infants but in only 5.3% of moderately preterm infants. For infants with GA less than 32 weeks, the specificity was 26.6%, and for those with GA 32 weeks or more, it was 88.3%.


CONCLUSIONS
In this Mexican population of preterm infants, WINROP detected type 1 ROP early in 84.7% of very preterm infants and correctly identified 26.6% of infants who did not develop type 1 ROP. Uncertainties in dating of pregnancies and differences in postnatal conditions may be factors explaining the different outcomes of WINROP in this population.
Luz Consuelo
LC
Zepeda-Romero
Anna-Lena
AL
Hård
Larissa Maria
LM
Gomez-Ruiz
Jose Alfonso
JA
Gutierrez-Padilla
Eusebio
E
Angulo-Castellanos
Juan Carlos
JC
Barrera-de-Leon
Juan Manuel
JM
Ramirez-Valdivia
Cesareo
C
Gonzalez-Bernal
Claudia Ivette
CI
Valtierra-Santiago
Esperanza
E
Garnica-Garcia
Chatarina
C
Löfqvist
Ann
A
Hellström
D000465:Algorithms; D001724:Birth Weight / Q000502:physiology*; D003906:Developing Countries; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007363:Intensive Care Units, Neonatal; D008800:Mexico; D015997:Neonatal Screening / Q000379:methods*; D012178:Retinopathy of Prematurity / Q000097:blood / Q000145:classification / Q000175:diagnosis*; D012189:Retrospective Studies
D007334:Insulin-Like Growth Factor I