[Effect of Xuebijing injection treatment on acute respiratory distress syndrome: a multicenter prospective randomized control clinical trial].
OBJECTIVE
To assess the therapeutic effect of Xuebijing injection on adult patients with acute respiratory distress syndrome (ARDS).


METHODS
A multicenter prospective randomized control study was conducted at 10 intensive care units in Jiangsu province. A total of 172 early ARDS patients were randomly divided into Xuebijing treatment and control groups. All patients received routine therapy of ARDS while additional Xuebijing injection 100 ml was administered in the treatment group intravenously for 7 days. Lung injury score, acute physiology and chronic health evaluation II (APACHE II) score, multiple organ dysfunction score (MODS) and PaO2/FiO2 of the patients was recorded before and after treatment. Mortality at 28 days and the duration of mechanical ventilation were compared between two groups.


RESULTS
Ninety-one patients were assigned to receive Xuebijing injection and 81 patients as control; Mortality at Days 28 and 90, the duration of mechanical ventilation and ventilation free days showed no difference between two groups (P > 0.05). PaO2/FiO2 improved after randomization versus pre-treatment in all patients. There was no significant difference between two groups. Murray scores were not significantly different between two groups. In a subgroup analysis of patients with pulmonary infection, pulmonary contusion and extra-pulmonary cause, two groups had no difference in mortality at Day 28, mortality at Day 90, the duration of mechanical ventilation, ventilation free days and days of ICU stay (P > 0.05).


CONCLUSIONS
The treatment of Xuebijing injection early in course of ARDS does not improve the mortality of ARDS patients. But it may improve lung function and oxygenation. Further studies are warranted.
Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Song-qiao
SQ
LIU
Rui-qiang
RQ
ZHENG
Mao-qin
MQ
LI
Jie
J
YAN
Hua-yao
HY
CHEN
Xin-wei
XW
MU
Rong-hua
RH
CHANG
Zheng-long
ZL
YE
Xiao-shi
XS
LI
Yong-he
YH
GAO
Xiao-hua
XH
QIU
Ying-zi
YZ
HUANG
Feng-mei
FM
GUO
Yi
Y
YANG
Hai-bo
HB
QIU
D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C549376:Xuebijing