Anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata.
A methanolic extract of Rhizophora apiculata was evaluated for its anti-inflammatory and anti-tumor activity against B16F10 melanoma cells in BALB/c mice. The administration of R. apiculata extract was shown to inhibit the solid tumor development in mice. R. apiculata treatment significantly reduced tumor cell glutathione (GSH) levels as well as serum γ-glutamyl transpeptidase (GGT) and nitric oxide (NO) levels in the tumor-bearing animals. The total white blood cell count and hemoglobin levels were also significantly increased in extract-treated hosts. The use of R. apiculata substantially reduced the acute inflammation (assessed as paw edema) induced by carrageenan and also reduced inflammation edema induced by formalin. Analysis of this methanolic extract revealed a high content of 4-pyrrolidinyl, pyrazole, and ketone derivatives. These studies suggest that R. apiculata extract could be used as a (natural) anti-inflammatory and anti-tumor agent.
Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore, Tamil Nadu, India.
V Vinod
VV
Prabhu
C
C
Guruvayoorappan
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000302:isolation & purification; D002351:Carrageenan / Q000276:immunology; D002853:Chromatography, Liquid; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008401:Gas Chromatography-Mass Spectrometry; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy*; D000432:Methanol / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D043982:Rhizophoraceae / Q000737:chemistry*; D012878:Skin Neoplasms / Q000188:drug therapy*; D023041:Xenograft Model Antitumor Assays
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D009569:Nitric Oxide; D002351:Carrageenan; D005978:Glutathione; D000432:Methanol