A possible brain network for representation of cooperative behavior and its implications for the psychopathology of schizophrenia.
It has been shown that social deficits contribute to psychopathology in schizophrenia, such as the bleulerian autism. A possible dysfunction in the mirror neuron system may be the reason for these deficits in the disorder. We wanted to better characterize the neural networks involved in the perception of social behavior. Fifteen healthy participants were presented with video clips of 8 seconds' duration depicting either (1) one actor manipulating an object, (2) two actors with only one manipulating an object or (3) two actors cooperating in manipulating an object and 2 other control conditions. Functional magnetic resonance imaging data were acquired during watching these videos. We found the perception of social cooperation is supported by a neural network comprising the precuneus, the temporoparietal junction (supramarginal gyrus, angular gyrus, BA 39/40), the middle temporal gyrus (including superior temporal sulcus) and frontal regions (medial frontal gyrus, inferior frontal gyrus). These areas form a complex network also being activated during theory of mind and cooperative behavior tasks. Its nodes overlap with those of the mirror neuron system. Consequently, both theory of mind abilities and mirror mechanisms are relevant in the perception and understanding of social cooperative behavior. We outline the consequences of these results for a further understanding of schizophrenic psychopathology with respect to social deficits and ego disturbances.
Department of Psychiatry, Philipps University Marburg, Marburg, Germany. leube@med.uni-marburg.de
Dirk
D
Leube
Benjamin
B
Straube
Antonia
A
Green
Isabelle
I
Blümel
Susanne
S
Prinz
Peter
P
Schlotterbeck
Tilo
T
Kircher
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D003299:Cooperative Behavior; D005625:Frontal Lobe / Q000502:physiology; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059167:Mirror Neurons / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013702:Temporal Lobe / Q000502:physiology; D056345:Theory of Mind / Q000502:physiology*