Effect of substitution at N″-position of N'-hydroxy-N-amino guanidines on tumor cell growth.
Structural modification of one of our earlier reported lead molecule (ABNM13) has been carried out to study the effect of different substituents at the N″-position of N-hydroxy-N'-amino guanidines (HAGs) on their anticancer activity. Compounds with electron donating substituents were found to be less active. In contrast, those with electron withdrawing groups were found favorable for anticancer activity. The obtained results provide significant SAR information that may be useful for further drug designing with HAGs.
Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, India. arijit4uin@gmail.com
Arijit
A
Basu
Barij Nayan
BN
Sinha
Philipp
P
Saiko
Thomas
T
Szekeres
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D021281:Quantitative Structure-Activity Relationship; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors / Q000378:metabolism
D000970:Antineoplastic Agents; D006146:Guanidines; D012264:Ribonucleotide Reductases