Neural substrates of childhood anxiety disorders: a review of neuroimaging findings.
The development of fear is a normative process, and significant progress has been made in identifying fear neurocircuitry. The normal development of fear goes awry in children who develop anxiety disorders, and dysfunction in fear circuitry is likely. In this article, the authors present current knowledge about the neural basis of normal fear development and reviews findings from structural and functional neuroimaging studies of childhood anxiety disorders.
Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Nashville, TN 37212, USA. Jennifer.Blackford@Vanderbilt.edu
Jennifer Urbano
JU
Blackford
Daniel S
DS
Pine
D000679:Amygdala / Q000473:pathology / Q000503:physiopathology*; D001008:Anxiety Disorders / Q000503:physiopathology / Q000523:psychology*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D005239:Fear / Q000502:physiology*; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology*