Genetics of pediatric anxiety disorders.
This article reviews the familiality, linkage, candidate gene, and genomewide association studies of obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and other anxiety disorders (ie, generalized anxiety disorder, separation anxiety disorder, social phobia, and specific phobia). Studies involving children and adolescents are highlighted. Clinical and research implications are discussed.
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Bellefield Towers, Room 515, 100 North Bellefield Avenue, Pittsburgh, PA 15213, USA. sakolskydj@upmc.edu
Dara J
DJ
Sakolsky
James T
JT
McCracken
Erika L
EL
Nurmi
D001008:Anxiety Disorders / Q000235:genetics*; D035843:Biomedical Research; D002648:Child; D057890:Epigenomics; D005796:Genes / Q000235:genetics*; D008040:Genetic Linkage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D010375:Pedigree; D020813:Receptor, trkB / Q000235:genetics; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology
C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D020813:Receptor, trkB