Cytochrome c heme lyase can mature a fusion peptide composed of the amino-terminal residues of horse cytochrome c.
It is shown that cytochrome c heme lyase (CCHL) attaches heme covalently to peptides composed of the N-terminal segment of cyt c fused to a non-heme containing protein, lending insight into the substrate specificity of CCHL and providing a new route to artificial heme proteins.
Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA.
Wesley B
WB
Asher
Kara L
KL
Bren
D000595:Amino Acid Sequence; D000818:Animals; D003574:Cytochrome c Group / Q000737:chemistry* / Q000378:metabolism; D006418:Heme / Q000737:chemistry* / Q000378:metabolism; D006736:Horses; D008190:Lyases / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity
D003574:Cytochrome c Group; D010455:Peptides; D006418:Heme; D008190:Lyases; C031581:cytochrome C synthetase