Serglycin in health and diseases.
Serglycin is a multifunctional molecule and one of the first proteoglycans to be cloned. In this manuscript, we examine the physiological roles of serglycin in immunity, hemostasis, cell growth, apoptosis, and reproduction. In addition, we review recent studies on the involvement of serglycin in various pathological conditions, including cancer, inflammatory diseases, and platelet disorders.
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Olivia J
OJ
Scully
Pei-Jou
PJ
Chua
Karthik S
KS
Harve
Boon-Huat
BH
Bay
George W
GW
Yip
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D049108:Cell Enlargement; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000097:blood / Q000502:physiology*; D012098:Reproduction / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000097:blood / Q000502:physiology*
D018836:Inflammation Mediators; D011509:Proteoglycans; D033921:Vesicular Transport Proteins; C075430:serglycin