Shedding light on local kinase activation.
Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.
Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine,1959 Pacific Ave, NE, Seattle, WA 98195 USA. scottjdw@u.washington.edu
John D
JD
Scott
Alexandra C
AC
Newton
D000818:Animals; D015374:Biosensing Techniques; D004789:Enzyme Activation / Q000528:radiation effects; D031541:Fluorescence Resonance Energy Transfer; D017930:Genes, Reporter; D006801:Humans; D008027:Light; D021962:Membrane Microdomains / Q000378:metabolism / Q000528:radiation effects; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000528:radiation effects
D011494:Protein Kinases; D019869:Phosphatidylinositol 3-Kinases