Bone turnover in hyperparathyroidism.
A narrow serum calcium level which is essential for many metabolic processes is regulated by the calcium-sensing receptor which regulates parathyroid hormone (PTH) release. Primary hyperparathyroidism is supposed to be the third most common endocrine disorder. Besides nephrolithiasis and an increased incidence of cardiovascular symptoms it is associated with bone loss and an increased risk of fracture. Several different classical bone turnover markers have been shown to be increased. However, there are many uncertainties in pathophysiology of PHPT. Hardly any conclusive data exist on the RANK (receptor activator of nuclear factor-kB)/RANKL (receptor activator of nuclear factor-kB ligand)/OPG (osteoprotegerin) system, cathepsin K, sclerostin, FGF-23 (Fibroblast growth factor-23), Klotho, and DKK 1 (Dickkopf 1) in patients suffering from PHPT.
Department of Physical Medicine and Rehabilitation, Medical University of Vienna, WaehringerGuertel 18-20, 1090, Vienna, Austria, katharina.kerschan-schindl@meduniwien.ac.at.
Katharina
K
Kerschan-Schindl
D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers / Q000097:blood; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology*; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases / Q000503:physiopathology; D056657:Cathepsin K / Q000502:physiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005819:Genetic Markers / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007669:Kidney Calculi / Q000503:physiopathology; D000090265:Klotho Proteins; D053244:Osteoprotegerin / Q000502:physiology; D010280:Parathyroid Glands / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000097:blood / Q000502:physiology; D044169:Receptors, Calcium-Sensing / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; C501126:DKK1 protein, human; C000717427:FGF23 protein, human; D005819:Genetic Markers; D036341:Intercellular Signaling Peptides and Proteins; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D053246:Receptor Activator of Nuclear Factor-kappa B; D044169:Receptors, Calcium-Sensing; C422903:SOST protein, human; C505686:TNFRSF11A protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; C534130:CTSK protein, human; D056657:Cathepsin K; D002118:Calcium