Meta-analysis of the association between angiotensin II receptor, type 1 gene A1166C polymorphism and coronary artery disease in Chinese populations.
BACKGROUND
and objective: Many studies have examined the association between the angiotensin II receptor, type 1 (AGTR1) gene A1166C polymorphism and coronary artery disease (CAD); the results, however, remain controversial. Given the accumulation of data, we conducted a meta-analysis of published studies on this association in Chinese.


METHODS
and results: A comprehensive search of PubMed, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases was conducted before January 2012. Data and study quality were assessed in duplicate. Twenty-two studies totaling 3502 CAD patients and 3071 controls were analyzed. Overall, individuals carrying 1166C allele had a remarkably increased risk of CAD compared with those with 1166AA genotype (odds ratio (OR)=1.63; 95% confidence interval (CI): 1.26-2.1; P<0.0005). In subgroup analyses by geography, the risk magnitude was slightly augmented in northern Chinese (OR=1.76; 95% CI: 1.23-2.52; P=0.002) relative to in southern Chinese (OR=1.55; 95% CI: 1.13-2.14; P=0.007). Grouping studies by average age detected a strong association in studies involving CAD patients aged ≥ 60 years. Differences in the diagnosis of CAD and source of controls might be potential sources of between-study heterogeneity.


CONCLUSIONS
Our findings provided strong evidence that AGTR1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects.
State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai, China.
Yuqiong
Y
Li
Xiaobo
X
Li
Nan
N
Jia
Shujie
S
Guo
Shaoli
S
Chu
Wenquan
W
Niu
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012044:Regression Analysis; D012307:Risk Factors
C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1