Cerebellar degeneration associated with Sjögren's syndrome.
BACKGROUND
Neurologic manifestations of primary Sjögren's syndrome (PSS) have been reported to vary from sensory polyneuropathy to encephalopathy or psychiatric problems. However, marked cerebellar degeneration associated with PSS has rarely been reported.


METHODS
We describe a patient with Sjögren's syndrome who exhibited rapidly progressive cerebellar ataxia, nystagmus, cognitive decline, and psychiatric problems. Brain magnetic resonance imaging revealed marked atrophy of the cerebellum, and (18)F-fluorodeoxyglucose positron-emission tomography demonstrated glucose hypometabolism of the cerebellum.


CONCLUSIONS
Our PSS patient exhibited a progressive course of cerebellar syndrome, as evidenced by cerebellar atrophy on serial brain images.
Department of Health Screening and Promotion Center, Asan Medical Center, Seoul, Korea.
Mi Jung
MJ
Kim
Myoung Chong
MC
Lee
Jae-Hong
JH
Lee
Sun Ju
SJ
Chung