Intraoperative detection of ganglioneuromas with 123I-MIBG.
Radioactive MIBG can be used in radioguided surgery for neuroendocrine tumors. We report the case of a man with a mutation in the succinate dehydrogenase subunit B (SDHB) gene, in which an abdominal MRI scan identified two 5-mm left para-aortic nodules, suspect for paragangliomas. Subsequent SPECT revealed increased uptake of tracer. 123I MIBG probe-guided resection was scheduled. During surgery, 2 small nodules with elevated activity in between the superior mesenteric artery and the left adrenal gland were identified by the detection probe and were resected. Histopathologic examination revealed mature ganglioneuromas.
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. L.T.van_Hulsteijn@lumc.nl
Leonie Theresia
LT
van Hulsteijn
Bernies
B
van der Hiel
Jan W A
JW
Smit
Marcel P
MP
Stokkel
Eleonora P M
EP
Corssmit
D019797:3-Iodobenzylguanidine; D000328:Adult; D005729:Ganglioneuroma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care; D008279:Magnetic Resonance Imaging; D008297:Male; D011877:Radionuclide Imaging
D019797:3-Iodobenzylguanidine