Microfluidics as a tool to understand the build-up mechanism of exponential-like growing films.
Microfluidics is used here for the first time to efficiently tune the growth conditions for understanding the build-up mechanism of exponentially growing polyelectrolyte (PE) films. The velocity of PE supply and time of interaction can be successfully altered during the layer-by-layer assembly. Another advantage of this method is that the deposition of poly-L-lysine/hyaluronic acid (PLL/HA) films in microchannels can be monitored online by fluorescence microscopy. The study demonstrates that PE mass transport to the film surface and diffusion in the film are key parameters affecting PLL/HA film build-up. Increase of PE supply rate results in a change in the "transition" (exponential-to-linear growth) towards higher number of deposition steps, thus indicating a mass transport-mediated growth mechanism.
Fraunhofer Institute of Biomedical Engineering, Am Mühlenberg 13, Potsdam-Golm, Germany.
Narayanan
N
Madaboosi
Katja
K
Uhlig
Magnus S
MS
Jäger
Helmuth
H
Möhwald
Claus
C
Duschl
Dmitry V
DV
Volodkin
D004573:Electrolytes; D006820:Hyaluronic Acid / Q000737:chemistry; D044085:Microfluidics; D008856:Microscopy, Fluorescence; D011107:Polylysine / Q000737:chemistry
D004573:Electrolytes; D011107:Polylysine; D006820:Hyaluronic Acid