Effect of sumatriptan on gastric emptying: a crossover study using the BreathID system.
OBJECTIVE
To determine the effect of oral sumatriptan on gastric emptying using a continuous ¹³C breath test (BreathID system).


METHODS
Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a test meal (200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg (sumatriptan condition), or the test meal alone (control condition). Gastric emptying was monitored for 4 h after administration of the test meal by the ¹³C-acetic acid breath test performed continually using the BreathID system. Then, using Oridion Research Software (β version), the time taken for emptying of 50% of the labeled meal (T(1/2)) similar to the scintigraphy lag time for 10% emptying of the labeled meal (T(lag)), the gastric emptying coefficient (GEC), and the regression-estimated constants (β and κ) were calculated. The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.


RESULTS
In the sumatriptan condition, significant differences compared with the control condition were found in T(1/2) [median 131.84 min (range, 103.13-168.70) vs 120.27 min (89.61-138.25); P = 0.0016], T(lag) [median 80.085 min (59.23-125.89) vs 61.11 min (39.86-87.05); P = 0.0125], and β [median 2.3374 (1.6407-3.8209) vs 2.0847 (1.4755-2.9269); P = 0.0284]. There were no significant differences in the GEC or κ between the 2 conditions.


CONCLUSIONS
This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.
Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Yasunari
Y
Sakamoto
Yusuke
Y
Sekino
Eiji
E
Yamada
Takuma
T
Higurashi
Hidenori
H
Ohkubo
Eiji
E
Sakai
Hiroki
H
Endo
Hiroshi
H
Iida
Takashi
T
Nonaka
Koji
K
Fujita
Masato
M
Yoneda
Tomoko
T
Koide
Hirokazu
H
Takahashi
Ayumu
A
Goto
Yasunobu
Y
Abe
Eiji
E
Gotoh
Shin
S
Maeda
Atsushi
A
Nakajima
Masahiko
M
Inamori
D000284:Administration, Oral; D000328:Adult; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes / Q000737:chemistry; D018592:Cross-Over Studies; D005746:Gastric Emptying; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012984:Software; D018170:Sumatriptan / Q000494:pharmacology*
D002247:Carbon Isotopes; D018170:Sumatriptan