title: Improvement of the bitter taste of drugs by complexation with cyclodextrins: applications, evaluations and mechanisms.
abstract: Drugs having bitter tastes cause low patient compliance. Many taste-masking techniques such as physical barrier coatings, chemical modification and sensory masking have been developed. Among chemical modification, the inclusion complexation of drugs with cyclodextrins (CyDs) can provide the effective bitter taste-masking effects without complicated formulation and/or delayed dissolution of drugs. Herein, we describe some quantitative methods to evaluate the taste-masking effects of CyD complexes with drugs in solution and the solid state. In addition, we introduce the recent applications of CyDs to excipients for taste masking against various bitter-taste drugs, as well as discuss the possible mechanisms for the taste-masking effect of CyD complexation.
authors: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. arimah@gpo.kumamoto-u.ac.jp
authors: Hidetoshi
authors: H
authors: Arima
authors: Taishi
authors: T
authors: Higashi
authors: Keiichi
authors: K
authors: Motoyama
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015374:Biosensing Techniques; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004304:Dosage Forms; D004339:Drug Compounding; D064420:Drug-Related Side Effects and Adverse Reactions; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D055118:Medication Adherence; D010470:Perceptual Masking; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D013649:Taste / Q000187:drug effects*; D055697:Taste Perception / Q000187:drug effects*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003505:Cyclodextrins; D004304:Dosage Forms; D005079:Excipients; D004364:Pharmaceutical Preparations