title: Protective effect of anti-oxidants on endothelial function in young Korean-Asians compared to Caucasians.
abstract: BACKGROUND
  Previous studies show that Asians have an impaired blood flow response (BFR) to occlusion after a single high fat (HF) meal. The mechanism is believed to be the presence and susceptibility to high free radicals in their blood. The free radical concentration after a HF meal has not been examined in Asians. Further the BFR to heat after a single HF meal in Koreans has not been measured.
  
  
  METHODS
  This study evaluated postprandial endothelial function by measuring the BFR to vascular occlusion and local heat before and after a HF meal and the interventional effects of anti-oxidant vitamins on improving endothelial function in young Korean-Asians (K) compared to Caucasians (C) with these assessments. Ten C and ten K participated in the study (mean age 25.3±3.6 years old). BFR to vascular occlusion and local heat and oxidative stress were assessed after a single low fat (LF) and HF meal at 2 hours compared to baseline. After administration of vitamins (1000 mg of vitamin C, 800 IU of vitamin E, and 300 mg of Coenzyme Q-10) for 14 days, the same measurements were made.
  
  
  RESULTS
  This study showed that the skin BFR to vascular occlusion and local heat following a HF meal significantly decreased and free radicals significantly increased at 2 hours compared to baseline in K (p<.001), but not in C. When vitamins were given, the BFR to vascular occlusion and local heat before and after HF meal were not significantly different in K and C.
  
  
  CONCLUSIONS
  These findings suggest that even a single HF meal can reduce endothelial response to stress through an oxidative stress mechanism but can be blocked by antioxidants, probably through scavenging free radicals in K. Since endothelial function improved even before a HF meal in K, endothelial damage from an Americanized diet may be reduced in K by antioxidants.
authors: Department of Physical Therapy, School of Allied Health Professions, Loma Linda University, Loma Linda, CA, USA.
authors: Jongeun
authors: J
authors: Yim
authors: Jerrold
authors: J
authors: Petrofsky
authors: Lee
authors: L
authors: Berk
authors: Noha
authors: N
authors: Daher
authors: Everett
authors: E
authors: Lohman
authors: Abigail
authors: A
authors: Moss
authors: Paula
authors: P
authors: Cavalcanti
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D044466:Asian People; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology; D044465:White People
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D014815:Vitamins; D008315:Malondialdehyde