title: Donor race and outcomes in kidney transplant recipients.
abstract: BACKGROUND
  African Americans are at greater risk to reach end-stage renal disease and this risk may carry over in a kidney transplant recipient after kidney transplantation.
  
  
  METHODS
  Linking the five-yr patient data of a large dialysis organization to the Scientific Registry of Transplant Recipients, we identified 13 692 hemodialysis patients who underwent first kidney transplantation. Mortality or graft failure and delayed graft function risks were estimated by Cox's regression (hazard ratio [HR] and 95% confidence interval) and logistic regression, respectively.
  
  
  RESULTS
  Patients were 48 ± 14 yr old and included 39% women and 26% patients with diabetes. After adjusting for several relevant clinical and transplant-related variables, African American donor race was associated with higher all-cause mortality, with HR of 1.39 (1.09-1.78) for all-cause mortality, 1.80 (1.17-2.76) for cardiovascular mortality, 1.30 (1.03-1.64) for death-censored graft loss and 1.31 (1.10-1.57) for combined outcome over the six-yr observation period. In the non-African American recipient subcohort, but not in the African American recipient subcohort, African American donor race was associated with higher risk of death-censored graft loss (2.24 [1.44-3.49]) in our fully adjusted model.
  
  
  CONCLUSIONS
  African American donor race was associated with increased all-cause and cardiovascular mortality and graft loss.
authors: Harold Simmons Center for Chronic Disease Research & Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA.
authors: Miklos Z
authors: MZ
authors: Molnar
authors: Csaba P
authors: CP
authors: Kovesdy
authors: Suphamai
authors: S
authors: Bunnapradist
authors: Elani
authors: E
authors: Streja
authors: Mahesh
authors: M
authors: Krishnan
authors: Istvan
authors: I
authors: Mucsi
authors: Keith C
authors: KC
authors: Norris
authors: Kamyar
authors: K
authors: Kalantar-Zadeh
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data*; D051799:Delayed Graft Function / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000401:mortality*; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015397:Program Evaluation; D011446:Prospective Studies; D012042:Registries; D006435:Renal Dialysis; D012307:Risk Factors; D015996:Survival Rate; D044465:White People / Q000706:statistics & numerical data*