title: Diverted organic synthesis (DOS): accessing a new, natural product inspired, neurotrophically active scaffold through an intramolecular Pauson-Khand reaction.
abstract: Drawing inspiration from the impressive neurotrophic activity exhibited by the natural product paecilomycine A, we have designed a new natural product-like scaffold employing an intramolecular Pauson-Khand reaction. Several compounds based on the new designer scaffold exhibited promising neurotrophic activity and are worthy of further biological evaluation. Our findings also highlight the importance of a DOS strategy in creating useful therapeutical leads.
authors: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. gmsc@uohyd.ernet.in
authors: Goverdhan
authors: G
authors: Mehta
authors: Ramesh
authors: R
authors: Samineni
authors: Pabbaraja
authors: P
authors: Srihari
authors: R Gajendra
authors: RG
authors: Reddy
authors: Sumana
authors: S
authors: Chakravarty
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D009414:Nerve Growth Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry*
chemical_list: D001688:Biological Products; D009414:Nerve Growth Factors; D013729:Terpenes; C520312:paecilomycine A