title: Towards understanding the phosphorylation code of tau.
abstract: We describe our efforts to combine in vitro enzymatic reactions with recombinant kinases to phosphorylate the neuronal tau protein, and NMR spectroscopy to unravel the resulting phosphorylation pattern in both qualitative and quantitative manners. This approach, followed by functional assays with the same samples, gives access to the complex phosphorylation code of tau. As a result, we propose a novel hypothesis for the link between tau (hyper)phosphorylation and aggregation.
authors: CNRS UMR 8576 University of Lille 1, 59655 Villeneuve d'Ascq, France. Guy.Lippens@univlille1.fr
authors: Guy
authors: G
authors: Lippens
authors: Laziza
authors: L
authors: Amniai
authors: Jean-Michel
authors: JM
authors: Wieruszeski
authors: Alain
authors: A
authors: Sillen
authors: Arnaud
authors: A
authors: Leroy
authors: Isabelle
authors: I
authors: Landrieu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins