title: Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.
abstract: Currently, there are no validated neurobiological methods for distinguishing different pathophysiological pathways in young patients presenting in the early phases of major psychiatric disorders. Hence, treatments are delivered simply on the basis of their possible effects on nonspecific symptom constructs such as depression, cognitive change or psychotic symptoms. In this study, the ratios (relative to creatine) of key metabolites (N-acetyl aspartate, myoinositol, glutamate and glutathione) were measured with proton magnetic resonance spectroscopy ((1)H-MRS) within the anterior cingulate cortex of 88 young persons presenting with major mood or psychotic symptoms. We derived empirically (using a cluster analytical technique) three subgroups of subjects on the basis of their patterns of in vivo brain biochemistry. The three subgroups were distinguished (from each other) by all the four metabolites, in particular, glutathione and glutamate. By contrast, the groups could not be distinguished by differences in terms of other demographic, functional or clinical measures. We propose that this (1)H-MRS-based subclassification system could be used as the basis for much more specific tests of novel intervention strategies (notably, antioxidant and glutamatergic therapies) early in the course of major psychiatric disorders.
authors: Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia. daniel.hermens@sydney.edu.au
authors: D F
authors: DF
authors: Hermens
authors: J
authors: J
authors: Lagopoulos
authors: S L
authors: SL
authors: Naismith
authors: J
authors: J
authors: Tobias-Webb
authors: I B
authors: IB
authors: Hickie
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D019090:Case Management; D003131:Combined Modality Therapy; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012016:Reference Values; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; C000179:N-acetylaspartate; D005978:Glutathione