title: Behavioral effects of original tetrapeptide, an analog of N-terminal nociceptin fragment.
abstract: The study examined the effect of an analog to N-terminal nociceptin fragment AcOH×Phe-Gly-Gly-Phe-NH(2) on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) significantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics of maturation of nervous structures involved in the realization of nociceptin action.
authors: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. katya.kilgor@gmail.com
authors: E A
authors: EA
authors: Ivanova
authors: N Yu
authors: NY
authors: Sarycheva
authors: V A
authors: VA
authors: Dubynin
authors: A V
authors: AV
authors: Malyshev
authors: V N
authors: VN
authors: Kalikhevich
authors: Z A
authors: ZA
authors: Ardemasova
authors: A A
authors: AA
authors: Kamensky
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009420:Nervous System / Q000187:drug effects / Q000254:growth & development; D018847:Opioid Peptides / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000819:agonists / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D000097629:Nociceptin
chemical_list: D018847:Opioid Peptides; D010446:Peptide Fragments; D011957:Receptors, Opioid; D000097629:Nociceptin