title: AB0 blood group and prognosis in patients with pancreatic cancer.
abstract: BACKGROUND
  Although blood group 0 is associated with a reduced risk of pancreatic cancer, little is known about the role of AB0 blood group antigens in disease progression. We assessed the prognostic relevance of AB0 blood status in a large cohort of patients with resected pancreatic cancer.
  
  
  METHODS
  A total of 627 patients, who underwent resection for pancreatic ductal adenocarcinoma between October 2001 and December 2008 were enrolled. The relationship between AB0 blood group status and outcome was analyzed using univariate and multivariate Cox regression analyses.
  
  
  RESULTS
  In patients with pancreatic cancer the incidence of blood group 0 (31%) was lower compared to 13.044 patients without pancreatic cancer (38%) (p = 0.0005). There were no significant differences in clinicopathologic characteristics among patients with different AB0 blood groups. The 3-year and 5-year overall survival rates were 29% and 14%. On univariate analysis AB0 blood group status did not correlate with survival (p = 0.39). Multivariate analysis, however, revealed a favorable and independent impact of blood group 0 on survival (Hazard ratio 0.78; 95% confidence interval 0.62 - 0.99; p = 0.037).
  
  
  CONCLUSIONS
  AB0 blood group status is associated independently with the prognosis of patients with resected pancreatic cancer.
authors: Department of General, Visceral and Transplant Surgery, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 110 69120, Germany. nuh.rahbari@med.uni-heidelberg.de
authors: Nuh N
authors: NN
authors: Rahbari
authors: Ulrich
authors: U
authors: Bork
authors: Ulf
authors: U
authors: Hinz
authors: Albrecht
authors: A
authors: Leo
authors: Johanna
authors: J
authors: Kirchberg
authors: Moritz
authors: M
authors: Koch
authors: Markus W
authors: MW
authors: Büchler
authors: Jürgen
authors: J
authors: Weitz
mesh_terms: D000017:ABO Blood-Group System; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D000017:ABO Blood-Group System