title: Caloric restriction improves basal redox parameters in hippocampus and cerebral cortex of Wistar rats.
abstract: Caloric restriction (CR) has been shown to either decrease or prevent the progression of several age-related pathologies. In previous work, we demonstrated that CR modulates astrocyte functions, suggesting that CR may exert neuroglial modulation. Here, we investigated the effects of CR on hippocampal (Hc) and cortical (Cx) oxidative stress parameters of male Wistar rats. Our results showed that CR-fed rats had 17% less body weight gain after 12 weeks of treatment. CR improved locomotion performance, increased glutathione levels and decreased glutathione peroxidase activity and the production of reactive oxygen species. However, no changes were observed in lipid peroxidation, nitric oxide content and catalase activity. Single cell gel electrophoresis assay (comet assay) revealed a reduction in the extent of basal DNA damage upon CR. Our data suggest that dietary CR could induce both hippocampal and cortical modulation resulting in metabolic changes and as a consequence, significant improvement of cellular defense-associated parameters.
authors: Research Group in Neuroglial Plasticity, Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. leticia.ribeiro@ufsc.br
authors: Leticia C
authors: LC
authors: Ribeiro
authors: Letícia
authors: L
authors: Rodrigues
authors: André
authors: A
authors: Quincozes-Santos
authors: Ana C
authors: AC
authors: Tramontina
authors: Victorio
authors: V
authors: Bambini-Junior
authors: Caroline
authors: C
authors: Zanotto
authors: Luisa A
authors: LA
authors: Diehl
authors: Regina
authors: R
authors: Biasibetti
authors: Juliana
authors: J
authors: Kleinkauf-Rocha
authors: Carla
authors: C
authors: Dalmaz
authors: Carlos-Alberto
authors: CA
authors: Goncalves
authors: Carmem
authors: C
authors: Gottfried
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D031204:Caloric Restriction; D002540:Cerebral Cortex / Q000378:metabolism*; D020552:Comet Assay; D004249:DNA Damage; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species