title: Evaluation of short-term fluoride release from fluoride varnishes.
abstract: OBJECTIVE
  The aim of this study was to compare the rate of fluoride release from fluoride varnishes over a 48-hour period and ascertain the time at which a plateau occurred. This data provides clinically relevant time points to resume tooth brushing after fluoride varnish application.
  
  
  METHODS
  Four commercially available fluoride varnishes, Premier Enamel ProVarnish (EP), Colgate PreviDent (CP), Omni Vanish (OV) and Omni VanishXT (OVXT) were applied on 40 extracted permanent human teeth. Ten teeth served as controls. The teeth were immersed in artificial saliva. At 1, 2, 4, 8, 12, 24 and 48 hours, the teeth were sequentially transferred to new vials. TISAB III and ion selective electrode was used to measure fluoride release. Statistical tools were used to compare the rates of fluoride release and plateau of fluoride release.
  
  
  RESULTS
  CP, EP and OV showed a plateau of fluoride release after 4 hours. OVXT did not show a significant change in fluoride release at any time point. EP had the highest fluoride release in the first 8 hours.
  
  
  CONCLUSIONS
  CP, EP and OV released maximum rate of fluoride release in the first 4 hours whereas OVXT did not have a plateau. The studied varnishes released different concentrations of fluoride despite the fact that they all contained 5% sodium fluoride.
authors: LSUHSC School of Dentistry, Department of Pediatric Dentistry, New Orleans, Louisiana, USA. pritwi@lsuhsc.edu
authors: P
authors: P
authors: Ritwik
authors: J D
authors: JD
authors: Aubel
authors: X
authors: X
authors: Xu
authors: Y
authors: Y
authors: Fan
authors: J
authors: J
authors: Hagan
mesh_terms: D002327:Cariostatic Agents / Q000737:chemistry*; D004058:Diffusion; D005460:Fluorides, Topical / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D008422:Materials Testing; D012464:Saliva, Artificial / Q000737:chemistry; D012969:Sodium Fluoride / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D012464:Saliva, Artificial; D012969:Sodium Fluoride