title: Analysis of urinary microRNAs in chronic kidney disease.
abstract: Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.
authors: Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
authors: Cristina
authors: C
authors: Beltrami
authors: Aled
authors: A
authors: Clayton
authors: Aled O
authors: AO
authors: Phillips
authors: Donald J
authors: DJ
authors: Fraser
authors: Timothy
authors: T
authors: Bowen
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000652:urine*; D006801:Humans; D035683:MicroRNAs / Q000652:urine*; D051436:Renal Insufficiency, Chronic / Q000235:genetics* / Q000652:urine*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs