title: A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer.
abstract: BACKGROUND
  Radiation-induced skin reaction (RISR) is one of the most common and distressing side effects of radiotherapy in patients with cancer. It is featured with swelling, redness, itching, pain, breaks in skin, discomfort, and a burning sensation. There is a lack of convincing evidence supporting any single practice in the prevention or management of RISR.
  
  
  METHODS
  This double-blinded randomised controlled trial aims to investigate the effects of a natural oil-based emulsion containing allantoin (as known as Moogoo Udder Cream®) versus aqueous cream in reducing RISR, improving pain, itching and quality of life in this patient group. One group will receive Moogoo Udder Cream®. Another group will receive aqueous cream. Outcome measures will be collected using patient self-administered questionnaire, interviewer administered questionnaire and clinician assessment at commencement of radiotherapy, weekly during radiotherapy, and four weeks after the completion of radiotherapy.
  
  
  CONCLUSIONS
  Despite advances of radiologic advances and supportive care, RISR are still not well managed. There is a lack of efficacious interventions in managing RISR. While anecdotal evidence suggests that Moogoo Udder Cream® may be effective in managing RISR, research is needed to substantiate this claim. This paper presents the design of a double blind randomised controlled trial that will evaluate the effects of Moogoo Udder Cream® versus aqueous cream for managing in RISR in patients with cancer.
  
  
  BACKGROUND
  ACTRN 12612000568819.
authors: Cancer Care Services, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, QLD Q4029, Australia. Raymond_chan@health.qld.gov.au
authors: Raymond Javan
authors: RJ
authors: Chan
authors: Jacqui
authors: J
authors: Keller
authors: Robyn
authors: R
authors: Cheuk
authors: Rae
authors: R
authors: Blades
authors: Lee
authors: L
authors: Tripcony
authors: Samantha
authors: S
authors: Keogh
mesh_terms: D000481:Allantoin / Q000737:chemistry* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000532:radiotherapy; D004311:Double-Blind Method; D004655:Emulsions / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D009821:Oils / Q000627:therapeutic use; D011855:Radiodermatitis / Q000188:drug therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D012107:Research Design
chemical_list: D004655:Emulsions; D009821:Oils; D000481:Allantoin