title: Bioactive polymeric metallosomes self-assembled through block copolymer-metal complexation.
abstract: Spontaneous formation of polymeric metallosomes with uniform size (~100 nm) was found to occur in aqueous medium through the reaction of an anticancer agent, (1,2-diaminocyclohexane)platinum(II) (DACHPt), with a Y-shaped block copolymer of ω-cholesteroyl-poly(L-glutamic acid) and two-armed poly(ethylene glycol) (PEGasus-PLGA-Chole). Circular dichroism spectrum measurements revealed that the PLGA segment forms an α-helix structure within the metallosomes, suggesting that secondary-structure formation of metallocomplexed PLGA segment may drive the self-assembly of the system into vesicular structure. These metallosomes can encapsulate water-soluble fluorescent macromolecules into their inner aqueous phase and eventually deliver them selectively into tumor tissues in mice, owing to the prolonged blood circulation. Accordingly, fluorescent imaging of the tumor was successfully demonstrated along with an appreciable antitumor activity by DACHPt moieties retained in the vesicular wall of the metallosomes, indicating the potential of metallosomes as multifunctional drug carriers.
authors: Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors: Kensuke
authors: K
authors: Osada
authors: Horacio
authors: H
authors: Cabral
authors: Yuki
authors: Y
authors: Mochida
authors: Sangeun
authors: S
authors: Lee
authors: Kazuya
authors: K
authors: Nagata
authors: Tetsuya
authors: T
authors: Matsuura
authors: Megumi
authors: M
authors: Yamamoto
authors: Yasutaka
authors: Y
authors: Anraku
authors: Akihiro
authors: A
authors: Kishimura
authors: Nobuhiro
authors: N
authors: Nishiyama
authors: Kazunori
authors: K
authors: Kataoka
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009944:Organoplatinum Compounds; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C013933:dichloro-1,2-diaminocyclohexane platinum complex