title: Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan.
abstract: We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acute promyelocytic leukemia (APL), the proportion of patients with myelodysplasia, unfavorable risk karyotypes, antecedent hematologic diseases, prior chemotherapy for other malignancies, and small proportion of blasts in the marrow was higher in patients ≥65 years, and patients with poor performance status (PS) and higher WBC counts at diagnosis were more prevalent among patients ≥75 years. One-third of the adult non-APL patients met the inclusion criteria usually applied in clinical trials: de novo AML, age ≤64 years with PS 0-2 and no key organ dysfunction. The 5-year overall survival (OS) rate of adult non-APL patients was 21.1 % (patients ≤64 years, 33.8 %; 65-74 years, 21.6 %; ≥75 years, 0 %). Multivariate analysis revealed that French-American-British subtypes M0, M6, and M7, poor PS (3, 4), unfavorable risk karyotypes, and higher WBC counts at diagnosis were independent adverse prognostic factors associated with OS. This analysis provides real world data.
authors: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
authors: Takuya
authors: T
authors: Matsunaga
authors: Kiyoshi
authors: K
authors: Yamashita
authors: Yoko
authors: Y
authors: Kubuki
authors: Takanori
authors: T
authors: Toyama
authors: Osamu
authors: O
authors: Imataki
authors: Kouichi
authors: K
authors: Maeda
authors: Noriaki
authors: N
authors: Kawano
authors: Seiichi
authors: S
authors: Satou
authors: Hiroshi
authors: H
authors: Kawano
authors: Junzo
authors: J
authors: Ishizaki
authors: Shuro
authors: S
authors: Yoshida
authors: Takuro
authors: T
authors: Kameda
authors: Tadashi
authors: T
authors: Sasaki
authors: Masaaki
authors: M
authors: Sekine
authors: Ayako
authors: A
authors: Kamiunten
authors: Yasuhiro
authors: Y
authors: Taniguchi
authors: Tomonori
authors: T
authors: Hidaka
authors: Keiko
authors: K
authors: Katayose
authors: Haruko
authors: H
authors: K-Shimoda
authors: Kotaro
authors: K
authors: Shide
authors: Shojiro
authors: S
authors: Yamamoto
authors: Hiroshi
authors: H
authors: Moritake
authors: Hiroyuki
authors: H
authors: Nunoi
authors: Shigeyoshi
authors: S
authors: Makino
authors: Akira
authors: A
authors: Kitanaka
authors: Hitoshi
authors: H
authors: Matsuoka
authors: Kazuya
authors: K
authors: Shimoda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult