title: E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions.
abstract: E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families.
authors: IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias s/n, Porto, Portugal.
authors: Patrícia
authors: P
authors: Carneiro
authors: Maria Sofia
authors: MS
authors: Fernandes
authors: Joana
authors: J
authors: Figueiredo
authors: Joana
authors: J
authors: Caldeira
authors: Joana
authors: J
authors: Carvalho
authors: Hugo
authors: H
authors: Pinheiro
authors: Marina
authors: M
authors: Leite
authors: Soraia
authors: S
authors: Melo
authors: Patrícia
authors: P
authors: Oliveira
authors: Joana
authors: J
authors: Simões-Correia
authors: Maria José
authors: MJ
authors: Oliveira
authors: Fátima
authors: F
authors: Carneiro
authors: Céu
authors: C
authors: Figueiredo
authors: Joana
authors: J
authors: Paredes
authors: Carla
authors: C
authors: Oliveira
authors: Raquel
authors: R
authors: Seruca
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D018095:Germ-Line Mutation; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology
chemical_list: D015820:Cadherins