title: Lipophilic caffeic acid derivatives protect cells against H2O2-Induced DNA damage by chelating intracellular labile iron.
abstract: Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular "labile" iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.
authors: Laboratory of Biological Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece.
authors: Natalia
authors: N
authors: Kitsati
authors: Demosthenes
authors: D
authors: Fokas
authors: Maria-Dimitra
authors: MD
authors: Ouzouni
authors: Michalis D
authors: MD
authors: Mantzaris
authors: Alexandra
authors: A
authors: Barbouti
authors: Dimitrios
authors: D
authors: Galaris
mesh_terms: D002109:Caffeic Acids / Q000494:pharmacology; D002934:Cinnamates / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects*; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D019169:Jurkat Cells; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; D007502:Iron Chelating Agents; D006861:Hydrogen Peroxide