title: A self-assembled delivery platform with post-production tunable release rate.
abstract: Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.
authors: Department of Chemical Engineering, Delft University of Technology , Julianalaan 136, 2628 BL Delft, The Netherlands.
authors: Job
authors: J
authors: Boekhoven
authors: Mathijs
authors: M
authors: Koot
authors: Tim A
authors: TA
authors: Wezendonk
authors: Rienk
authors: R
authors: Eelkema
authors: Jan H
authors: JH
authors: van Esch
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry; D002384:Catalysis; D002918:Chymotrypsin / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006358:Hot Temperature; D007700:Kinetics; D008081:Liposomes
chemical_list: D000634:Aminoquinolines; D004337:Drug Carriers; D005456:Fluorescent Dyes; D005782:Gels; D008081:Liposomes; C032928:6-aminoquinoline; D002918:Chymotrypsin