title: Treatment failure in osteoporosis.
abstract: Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided.
  
  
  BACKGROUND
  This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture.
  
  
  METHODS
  A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making.
  
  
  RESULTS
  In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by anti-resorptive therapy and where bone mineral density continues to decrease.
  
  
  CONCLUSIONS
  The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue.
authors: Department of Internal Medicine and Infectious Diseases, Hospital del Mar-IMIM, Autonomous University of Barcelona, RETICEF, Instituto Carlos III, P. Maritim 25-29, 08003 Barcelona, Spain. adiez@parcdesalutmar.cat
authors: A
authors: A
authors: Diez-Perez
authors: J D
authors: JD
authors: Adachi
authors: D
authors: D
authors: Agnusdei
authors: J P
authors: JP
authors: Bilezikian
authors: J E
authors: JE
authors: Compston
authors: S R
authors: SR
authors: Cummings
authors: R
authors: R
authors: Eastell
authors: E F
authors: EF
authors: Eriksen
authors: J
authors: J
authors: Gonzalez-Macias
authors: U A
authors: UA
authors: Liberman
authors: D A
authors: DA
authors: Wahl
authors: E
authors: E
authors: Seeman
authors: J A
authors: JA
authors: Kanis
authors: C
authors: C
authors: Cooper
mesh_terms: D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D006801:Humans; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D058866:Osteoporotic Fractures / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents