title: HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.
abstract: Homozygosity for a 32 bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment.
authors: IrsiCaixa and AIDS Unit, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
authors: Ester
authors: E
authors: Ballana
authors: Eva
authors: E
authors: Riveira-Munoz
authors: Christian
authors: C
authors: Pou
authors: Vanessa
authors: V
authors: Bach
authors: Mariona
authors: M
authors: Parera
authors: Marc
authors: M
authors: Noguera
authors: José R
authors: JR
authors: Santos
authors: Roger
authors: R
authors: Badia
authors: Maria
authors: M
authors: Casadellà
authors: Bonaventura
authors: B
authors: Clotet
authors: Roger
authors: R
authors: Paredes
authors: Miguel Angel
authors: MA
authors: Martínez
authors: Christian
authors: C
authors: Brander
authors: José A
authors: JA
authors: Esté
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D000483:Alleles; D001483:Base Sequence; D005260:Female; D015497:HIV-1; D059871:HLA-A24 Antigen / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology; D017384:Sequence Deletion; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: C438506:HLA-A*24:02 antigen; D059871:HLA-A24 Antigen; D015235:HLA-B Antigens; C484830:HLA-B*57:01 antigen; D019713:Receptors, CCR5