title: Polydatin attenuates hypoxic pulmonary hypertension and reverses remodeling through protein kinase C mechanisms.
abstract: Hypoxic pulmonary hypertension is a life-threatening emergency if untreated. Consistent pulmonary hypertension also leads to arteries and ventricular remodeling. The clinical therapeutic strategy for pulmonary hypertension and the corresponding remodeling mainly interacts with NO, angiotensin II (Ang II) and elevated endothelin (ET) targets. In the present study, we evaluated the effects of polydatin on hypoxia-induced pulmonary hypertension. It was observed that polydatin attenuated hypoxic pulmonary hypertension, reversed remodeling, and regulated NO, Ang II, ET contents in the serum and lung samples. However, forced activation of PKC signaling by its selective activator thymeleatoxin (THX) could abate the effects of polydatain. These results suggest that polydatin might be a promising candidate for hypoxic pulmonary treatment through interaction with PKC mechanisms.
authors: Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China.
authors: Qing
authors: Q
authors: Miao
authors: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Xiao-Peng
authors: XP
authors: Shi
authors: Department of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Ming-Xiang
authors: MX
authors: Ye
authors: Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Jin
authors: J
authors: Zhang
authors: Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China.
authors: Shan
authors: S
authors: Miao
authors: Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China.
authors: Si-Wang
authors: SW
authors: Wang
authors: Department of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Bo
authors: B
authors: Li
authors: Department of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Xiu-Xiu
authors: XX
authors: Jiang
authors: Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China.
authors: Song
authors: S
authors: Zhang
authors: Institute of Stomatology, General Hospital of People's Liberation Army, Beijing 100853, China.
authors: Nan
authors: N
authors: Hu
authors: Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.
authors: Juan
authors: J
authors: Li
authors: Department of Pulmonary Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Jian
authors: J
authors: Zhang
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D016232:Endothelins / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010703:Phorbol Esters / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects*; D013267:Stilbenes / Q000494:pharmacology*; D066253:Vascular Remodeling / Q000187:drug effects*
chemical_list: D016232:Endothelins; D005960:Glucosides; D010703:Phorbol Esters; D013267:Stilbenes; D000804:Angiotensin II; D009569:Nitric Oxide; C080287:thymeleatoxin; D011493:Protein Kinase C; C058229:polydatin