title: Helios expression in FoxP3(+) T regulatory cells.
abstract: Recent work debates the suitability of Helios, an Ikarios family transcription factor, as a marker of thymic-derived natural T regulatory cells. However, Helios expression could be of particular importance in cancer. We and others reported that the majority of peripheral and tumour-infiltrating FoxP3(+) Tregs expresses Helios. Additionally, recent observations indicate that FoxP3(+)Helios(+) Tregs possess more suppressive characteristics, as compared to FoxP3(+)Helios(-) Tregs.
authors: Eyad
authors: E
authors: Elkord
authors: Basel K
authors: BK
authors: Al-Ramadi
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D006801:Humans; D051740:Ikaros Transcription Factor / Q000096:biosynthesis*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C111431:IKZF2 protein, human; D014157:Transcription Factors; D051740:Ikaros Transcription Factor