title: Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
abstract: Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.
authors: Institut de Biologie et Chimie des Protéines, Centre National de la Recherche Scientifique (CNRS) FRE 3310, Lyon, France; Université de Lyon 1, FRE 3310, Lyon, France.
authors: Bérengère
authors: B
authors: Fromy
authors: Eric
authors: E
authors: Lingueglia
authors: Dominique
authors: D
authors: Sigaudo-Roussel
authors: Jean Louis
authors: JL
authors: Saumet
authors: Michel
authors: M
authors: Lazdunski
mesh_terms: D062565:Acid Sensing Ion Channels / Q000172:deficiency / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D000328:Adult; D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002116:Calcitonin / Q000037:antagonists & inhibitors; D003064:Cnidarian Venoms / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011312:Pressure / Q000009:adverse effects; D003668:Pressure Ulcer / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011498:Protein Precursors / Q000037:antagonists & inhibitors; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016037:Single-Blind Method; D012867:Skin / Q000098:blood supply*; D014664:Vasodilation / Q000502:physiology*; D055815:Young Adult
chemical_list: C501880:APETx2 protein, Anthopleura elegantissima; C112231:ASIC3 protein, human; C508378:ASIC3 protein, mouse; C568269:ASIC3 protein, rat; D062565:Acid Sensing Ion Channels; D003064:Cnidarian Venoms; D011498:Protein Precursors; D004008:Diclofenac; D000584:Amiloride; D002116:Calcitonin