title: Management of a dichorionic twin pregnancy with a normal fetus and an androgenetic diploid complete hydatidiform mole.
abstract: We describe a rare case of complete hydatidiform mole with twin live fetus (CHMTF) confirmed by histopathology, flow cytometry, and polymerase chain reaction techniques. No malformations were observed, fetal karyotype was normal and β-human chorionic gonadotropin levels were increased (>100,000 IU/ml). Once the patient had been informed of the risks, it was decided to continue the pregnancy, but termination of pregnancy was necessary at week 13 + 5 due to maternal complications consisting of hyperthyroidism, hypertension and vaginal bleeding, followed by persistent trophoblastic disease (PTD). Patients diagnosed with CHMTF should be informed of all known risks, including the considerable risk of PTD, which is similar to - or according to some reports - even higher than that associated with a singleton complete mole and is not increased by continuing pregnancy. Due to the low number of series published, evidence-based clinical management guidelines are lacking.
authors: Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, El Palmar, Spain. marisasanchezf@yahoo.es
authors: María Luisa
authors: ML
authors: Sánchez-Ferrer
authors: Francisco
authors: F
authors: Machado-Linde
authors: Alicia
authors: A
authors: Martínez-Espejo Cerezo
authors: Carolina
authors: C
authors: Peñalver Parres
authors: Belén
authors: B
authors: Ferri
authors: Isabel
authors: I
authors: López-Expósito
authors: Lorenzo
authors: L
authors: Abad
authors: Juan José
authors: JJ
authors: Parrilla
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004171:Diploidy; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D011247:Pregnancy; D059285:Pregnancy, Twin; D012307:Risk Factors; D014463:Ultrasonography