title: Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.
abstract: Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8(+) T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8(+) T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal dehydrogenase in the draining lymph nodes following the i.m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell response in the gut-mucosal compartment following the i.m. Adv vaccination.
authors: Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
authors: Masaki
authors: M
authors: Shoji
authors: Masashi
authors: M
authors: Tachibana
authors: Kazufumi
authors: K
authors: Katayama
authors: Kyoko
authors: K
authors: Tomita
authors: Sayaka
authors: S
authors: Tsuzuki
authors: Fuminori
authors: F
authors: Sakurai
authors: Kenji
authors: K
authors: Kawabata
authors: Ken J
authors: KJ
authors: Ishii
authors: Shizuo
authors: S
authors: Akira
authors: Hiroyuki
authors: H
authors: Mizuguchi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D062705:Adenovirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005822:Genetic Vectors / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D007113:Immunity, Innate; D007273:Injections, Intramuscular; D007370:Interferon Type I / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D053633:Receptor, Interferon alpha-beta / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014212:Tretinoin / Q000378:metabolism; D014611:Vaccination
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D062705:Adenovirus Vaccines; D016827:CD8 Antigens; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D007370:Interferon Type I; D053633:Receptor, Interferon alpha-beta; D014212:Tretinoin; C512612:MAVS protein, mouse; C508034:Ifnar2 protein, mouse