title: Privileged scaffolds in synthesis: 2,5-piperazinediones as templates for the preparation of structurally diverse heterocycles.
abstract: 2,5-Piperazinediones (2,5-diketopiperazines, DKPs) can be viewed as privileged building blocks for the synthesis of heterocyclic systems. This tutorial review aims at underscoring the large number and structural variety of nitrogen heterocycles that are available by suitable manipulation of DKP starting materials, including many bioactive compounds and natural products.
authors: Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
authors: Juan F
authors: JF
authors: González
authors: Irene
authors: I
authors: Ortín
authors: Elena
authors: E
authors: de la Cuesta
authors: J Carlos
authors: JC
authors: Menéndez
mesh_terms: D002244:Carbon / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D009584:Nitrogen / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D010879:Piperazines; D002244:Carbon; D009584:Nitrogen