title: Hyper-eosinophilia in granular acute B-cell lymphoblastic leukemia with myeloid antigen expression.
abstract: Acute lymphoblastic leukemia with eosinophilia (ALLEo) is a rare but a distinctive clinical entity. Clinical features of idiopathic hyper-eosinophilic syndrome (HES) can be seen in patients with ALLEo. We report a 10-year-old girl, in whom HES was initially suspected but further investigation confirmed the diagnosis of acute B-cell lymphoblastic leukemia with myeloid antigen expression. Clinical response to chemotherapy was excellent with achievement of complete remission for 4 years. Serum interleukin-3 and -5 were elevated at presentation and normalized with disappearance of eosinophilia after induction therapy, supporting the reactive nature of eosinophilia in ALLEo. Hematologic malignancy should be considered in patients with hyper-eosinophilia, before attributing it to HES.
authors: Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201-2119, USA. dkobayas@dmc.org
authors: Daisuke
authors: D
authors: Kobayashi
authors: Kazuhiro
authors: K
authors: Kogawa
authors: Kohsuke
authors: K
authors: Imai
authors: Toshio
authors: T
authors: Tanaka
authors: Akiko
authors: A
authors: Sada
authors: Shigeaki
authors: S
authors: Nonoyama
mesh_terms: D002648:Child; D004802:Eosinophilia / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D015448:Leukemia, B-Cell / Q000150:complications / Q000276:immunology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000276:immunology*; D063268:Sialic Acid Binding Ig-like Lectin 3 / Q000096:biosynthesis*
chemical_list: D063268:Sialic Acid Binding Ig-like Lectin 3