title: Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature.
abstract: Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation.
authors: Department of Oral Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
authors: Prokopios P
authors: PP
authors: Argyris
authors: Stefan E
authors: SE
authors: Pambuccian
authors: Zuzan
authors: Z
authors: Cayci
authors: Charanjeet
authors: C
authors: Singh
authors: Konstantinos I
authors: KI
authors: Tosios
authors: Ioannis G
authors: IG
authors: Koutlas
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000473:pathology*; D054338:Cell Transdifferentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007765:Lacrimal Apparatus / Q000473:pathology*; D007766:Lacrimal Apparatus Diseases / Q000378:metabolism / Q000473:pathology*; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology*; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor