title: Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage.
abstract: A shift from type 1 to type 2 immune bias is essential for successful implantation and pregnancy. ST2 is a receptor present on type 2 immune cells and IL-33 was recently discovered to be its ligand. We measured serum levels of soluble ST2 (sST2) and IL-33 across the mid-first trimester and examined whether levels were dysregulated among women with a viable fetus but destined to miscarry. While there was no significant change in sST2 or IL-3 across the first trimester, we found that women with live pregnancies destined to fail had dysregulated levels of serum IL-33, and potentially sST2 at six weeks' gestation.
authors: Translational Obstetrics Group, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, Australia. t.klino@unimelb.edu.au
authors: Tu'uhevaha J
authors: TJ
authors: Kaitu'u-Lino
authors: Laura
authors: L
authors: Tuohey
authors: Stephen
authors: S
authors: Tong
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D000328:Adult; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface