title: Postpartum herpes simplex virus endometritis and disseminated infection in both mother and neonate.
abstract: BACKGROUND
  Herpes simplex virus (HSV) is an unusual cause of postpartum endometritis. We describe a rare case of primary disseminated maternal HSV in the postpartum period associated with endometritis.
  
  
  METHODS
  A previously healthy patient developed fundal tenderness and postpartum fevers after an uncomplicated vaginal delivery. Despite traditional broad-spectrum antimicrobial therapy, she had persistent fevers and systemic symptoms. Concurrently, her neonate developed fevers and a nonvesicular rash, with viral cultures ultimately returning positive for HSV. The patient developed active pharyngeal and genital herpetic lesions and was diagnosed with HSV endometritis and disseminated HSV. Symptoms and fevers in both the mother and neonate responded to antiviral therapy.
  
  
  CONCLUSIONS
  Herpes simplex virus endometritis should be included in the differential diagnosis for postpartum fevers and fundal tenderness that are unresponsive to broad-spectrum antimicrobial treatment.
authors: From the Departments of Obstetrics and Gynecology and Infectious Diseases, Naval Medical Center San Diego, San Diego, California.
authors: April L
authors: AL
authors: McGill
authors: Mary F
authors: MF
authors: Bavaro
authors: Whitney B
authors: WB
authors: You
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D004716:Endometritis / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D005076:Exanthema / Q000188:drug therapy / Q000821:virology; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000821:virology; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir