title: Repetition suppression and effects of familiarity on blood oxygenation level dependent signal and gamma-band activity.
abstract: We used an identical repetition priming paradigm in functional MRI (fMRI) and magnetoencephalography (MEG) to investigate brain networks modulated by stimulus repetition and familiarity. In particular, pictures of familiar or unfamiliar objects were presented sequentially, with stimulus repetitions occurring within few trials. The results of both studies indicated close agreement between the pattern found in fMRI-BOLD (blood oxygenation level dependent) responses and in source localizations of induced gamma-band activity derived from MEG. In both studies, the brain regions that were significantly associated with repetition suppression in response to familiar visual objects encompassed bilaterally the medial and lateral occipital cortex, inferior occipitotemporal regions including the left fusiform cortex, as well as parietal areas. Modulations by stimulus familiarity occurred mainly within this network. Overall, we found noticeable correspondences between the results of fMRI-BOLD signals and MEG gamma-band activity, suggesting that both methods can be used in analogous ways to study the neural basis of repetition priming and object recognition.
authors: Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. u.friese@uke.de
authors: Uwe
authors: U
authors: Friese
authors: Benjamin
authors: B
authors: Rahm
authors: Uwe
authors: U
authors: Hassler
authors: Jochen
authors: J
authors: Kaiser
authors: Thomas
authors: T
authors: Gruber
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D010100:Oxygen / Q000097:blood*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen