title: The 34,XY1,der(13) chromosome constitution with loss of Y2 is associated with unilateral testicular hypoplasia in the endangered Indian blackbuck antelope (Antilope cervicapra).
abstract: The present study is the first report of unilateral testicular hypoplasia in 3 of 15 (20%) Indian blackbuck antelopes (Antilope cervicapra). Interestingly, the condition was restricted to only the right testis in all cases. Cytogenetic analysis revealed chromosomal aneuploidy in the affected individuals which had a 34,XY(1),der(13) karyotype with loss of the acrocentric (autosomal) Y(2) and an aberrant chromosome 13. We further determined that the semen output and the circulating testosterone levels were markedly low in the males with hypoplastic testes as compared to fertile males.
authors: Laboratory for the Conservation of Endangered Species Annexe I and Chromosome Diagnostics Facility, Clinical Research Facility-Medical Biotechnology Annexe II, Centre for Cellular and Molecular Biology (CSIR), Hyderabad, India.
authors: S D
authors: SD
authors: Sontakke
authors: L R
authors: LR
authors: Kandukuri
authors: G
authors: G
authors: Umapathy
authors: K M
authors: KM
authors: Kulashekaran
authors: P O
authors: PO
authors: Venkata
authors: S
authors: S
authors: Shivaji
authors: L
authors: L
authors: Singh
mesh_terms: D000818:Animals; D000866:Antelopes / Q000235:genetics*; D002871:Chromosome Banding; D033481:Chromosomes, Mammalian / Q000235:genetics*; D056727:Endangered Species; D005298:Fertility; D007194:India; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D012661:Semen / Q000378:metabolism; D013737:Testis / Q000002:abnormalities* / Q000378:metabolism; D014960:X Chromosome / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*