title: New xanthone glycosides from Comastoma pedunculatum.
abstract: Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays. Among them, compounds 3 and 5 exhibited potent hepatoprotective activity. However, none of the compounds displayed cytotoxic activity.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
authors: Yongqi
authors: Y
authors: Qiao
authors: Yi
authors: Y
authors: Yuan
authors: Baosong
authors: B
authors: Cui
authors: Ying
authors: Y
authors: Zhang
authors: Hui
authors: H
authors: Chen
authors: Shuai
authors: S
authors: Li
authors: Yan
authors: Y
authors: Li
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D004847:Epithelial Cells / Q000187:drug effects; D005688:Galactosamine / Q000009:adverse effects; D029965:Gentianaceae / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D051381:Rats; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D044004:Xanthones; D005688:Galactosamine; C009689:xanthone