title: The functional polymorphism of erythropoietin gene rs1617640 G>T is not associated with susceptibility and clinical outcome of early-stage breast cancer.
abstract: Recent data suggest that erythropoietin (EPO) plays a substantial role in cancer development and clinical outcome by stimulating cell proliferation, invasion and angiogenesis. A functional polymorphism (rs1617640 G>T) in the promoter region of the EPO gene increases EPO protein expression. In the present study, we investigated the association of EPO rs1617640 G>T with susceptibility and clinical outcome of early-stage breast cancer. Genomic DNA of 539 female patients with histologically confirmed early-stage breast cancer and 804 controls was genotyped for EPO rs1617640 G>T. No association was found between EPO rs1617640 G>T and early-stage breast cancer susceptibility and clinical outcome (hazard ratio=1.24, 95% confidence interval=1.82-1.90, p=0.31). In conclusion, our findings suggest a lack of influence of EPO rs1617640 G>T on early-stage breast carcinogenesis and clinical outcome.
authors: Division of Clinical Oncology, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
authors: Joanna
authors: J
authors: Szkandera
authors: Gudrun
authors: G
authors: Absenger
authors: Michael
authors: M
authors: Stotz
authors: Melanie
authors: M
authors: Weissmueller
authors: Thomas
authors: T
authors: Winder
authors: Tanja
authors: T
authors: Langsenlehner
authors: Hellmut
authors: H
authors: Samonigg
authors: Wilfried
authors: W
authors: Renner
authors: Walter
authors: W
authors: Schippinger
authors: Armin
authors: A
authors: Gerger
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D004921:Erythropoietin / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D016896:Treatment Outcome
chemical_list: D004921:Erythropoietin