title: Epilepsy surgery after treatment of pediatric malignant brain tumors.
abstract: Epilepsy surgery is common in the face of benign brain tumors, but rarely for patients with a history of malignant brain tumors. Seizures are a common sequelae in survivors of malignant pediatric brain tumors. Medical management alone may not adequately treat epilepsy, including in this group. We report four cases of patients who previously underwent gross total resection, radiation therapy, and chemotherapy for successful treatment of malignant brain neoplasia, yet suffered from medically intractable seizures. All underwent surgery for treatment of epilepsy with extension of the original resection. Despite the aggressive primary treatment of the neoplasm, and the potential for diffuse cerebral insults, all benefited from focal surgical resection. Aggressive surgical management of intractable epilepsy can be considered in survivors of malignant brain tumors.
authors: Department of Neurological Surgery, University of Washington, USA. jojemann@uw.edu
authors: Jeffrey G
authors: JG
authors: Ojemann
authors: Tamir Y
authors: TY
authors: Hersonskey
authors: Sergey
authors: S
authors: Abeshaus
authors: J Russell
authors: JR
authors: Geyer
authors: Russell P
authors: RP
authors: Saneto
authors: Edward J
authors: EJ
authors: Novotny
authors: Peter
authors: P
authors: Kollros
authors: Sarah
authors: S
authors: Leary
authors: Mark D
authors: MD
authors: Holmes
mesh_terms: D001932:Brain Neoplasms / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects; D017741:Survivors; D055815:Young Adult