title: Subsequent nonmelanoma skin cancer after liver transplantation.
abstract: BACKGROUND
  Liver transplant recipients have a high risk of developing nonmelanoma skin cancer (NMSC). Some develop multiple NMSC.
  
  
  METHODS
  Patients with a follow-up of >1 year have been prospectively followed to detect NMSC. We studied the risk of developing >1 NMSC.
  
  
  RESULTS
  After a follow-up of 2658 patient-years (mean, 8.5 years per patient), 59/312 (19%) patients were diagnosed with NMSC. Twenty-five had >1 NMSC. The 5-year risk of developing 1 NMSC, >1 NMSC, and a subsequent NMSC (a new NMSC after a first one) were 15%, 5.5%, and 46.5%, respectively. Age >60 years and transplantation for hepatocellular carcinoma were independently associated with a higher risk of developing >1 NMSC.
  
  
  CONCLUSIONS
  NMSC are frequent complications after liver transplantation and they may show a high rate of recurrence. Older age and hepatocellular carcinoma were related to the development of multiple NMSC.
authors: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, and the Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain. iherrero@unav.es
authors: J I
authors: JI
authors: Herrero
authors: A
authors: A
authors: España
authors: D
authors: D
authors: D'Avola
authors: F
authors: F
authors: Pardo
authors: M
authors: M
authors: Iñarrairaegui
authors: F
authors: F
authors: Rotellar
authors: B
authors: B
authors: Sangro
authors: J
authors: J
authors: Quiroga
mesh_terms: D000367:Age Factors; D002280:Basal Cell Carcinoma / Q000209:etiology*; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008107:Liver Diseases / Q000601:surgery*; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016609:Neoplasms, Second Primary / Q000209:etiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000209:etiology*; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome