title: Differential expression of the Toll-like receptor pathway and related genes of chicken bursa after experimental infection with infectious bursa disease virus.
abstract: Infectious bursa disease virus causes an acute infection in bursal B cells. The Toll-like receptor (TLR) signaling pathway plays a key role in innate immunity during virus infection. In this study, an Agilent microarray was used to investigate different transcriptional profiles of the TLR pathway and related genes of chicken bursa at 48 h after infection with IBDV, compared with simulated infection. Expression of >58 genes changed significantly. Forty-six genes associated with chicken bursa proinflammatory effects, chemotactic effects, and T-cell stimulation were upregulated, which meant enhancement of these features. Twelve genes that are related to proliferation and differentiation of bursal cells were downregulated, implying suppression of these features. These results revealed that genes of the TLR pathway play an important role in the pathogenicity of IBDV infection. The findings are helpful for understanding the molecular basis of viral pathogenesis and the underlying mechanism of the host antiviral response.
authors: College of Animal Science and Technology, Beijing University of Agriculture, Changping District, Beijing 102206, China.
authors: Xinfeng
authors: X
authors: Guo
authors: Liqiong
authors: L
authors: Wang
authors: Defeng
authors: D
authors: Cui
authors: Wenke
authors: W
authors: Ruan
authors: Fenghua
authors: F
authors: Liu
authors: Huanrong
authors: H
authors: Li
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000276:immunology / Q000821:virology; D002645:Chickens; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D007243:Infectious bursal disease virus / Q000276:immunology* / Q000472:pathogenicity*; D008297:Male; D046228:Microarray Analysis; D015398:Signal Transduction; D013997:Time Factors; D051193:Toll-Like Receptors / Q000096:biosynthesis*
chemical_list: D051193:Toll-Like Receptors