title: Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity.
abstract: 4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes, we developed a compound library based on this heterocyclic scaffold. We found that several library members displayed low micromolar antiproliferative activity and induced apoptosis in human cancer cells. Selected compounds showed promising activity against cancer cell lines resistant to proapoptotic stimuli, demonstrating their potential in treating cancers with dismal prognoses.
authors: Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA. imagedov@nmt.edu
authors: Igor V
authors: IV
authors: Magedov
authors: Artem S
authors: AS
authors: Kireev
authors: Aaron R
authors: AR
authors: Jenkins
authors: Nikolai M
authors: NM
authors: Evdokimov
authors: Dustin T
authors: DT
authors: Lima
authors: Paul
authors: P
authors: Tongwa
authors: Jeff
authors: J
authors: Altig
authors: Wim F A
authors: WF
authors: Steelant
authors: Severine
authors: S
authors: Van slambrouck
authors: Mikhail Yu
authors: MY
authors: Antipin
authors: Alexander
authors: A
authors: Kornienko
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D061986:MCF-7 Cells; D008968:Molecular Conformation; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D009285:Naphthoquinones