title: Consequences of delayed ciprofloxacin and doxycycline treatment regimens against Francisella tularensis airway infection.
abstract: This study examines the efficacy, bacterial load, and humoral response of extensively delayed ciprofloxacin or doxycycline treatments following airway exposure of mice to Francisella tularensis subsp. holarctica (strain LVS) or to the highly virulent F. tularensis subsp. tularensis (strain SchuS4). A delay in onset of both antibiotic treatments allowed the rescue of all LVS-infected animals. However, for animals infected with SchuS4, only ciprofloxacin was efficacious and prolongation of treatment rescued all animals.
authors: Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.
authors: Shahar
authors: S
authors: Rotem
authors: Erez
authors: E
authors: Bar-Haim
authors: Hila
authors: H
authors: Cohen
authors: Uri
authors: U
authors: Elia
authors: Raphael
authors: R
authors: Ber
authors: Avigdor
authors: A
authors: Shafferman
authors: Ofer
authors: O
authors: Cohen
mesh_terms: D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D005604:Francisella tularensis / Q000187:drug effects* / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D014406:Tularemia / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin; D004318:Doxycycline