title: Late skip lymph node metastasis of oral squamous cell carcinoma or metastasis of unknown second primary tumor? Answer by mitochondrial DNA analysis.
abstract: Patients with head and neck squamous cell carcinoma (SCC) are at risk of developing additional tumors in the head and neck. The detection of a late lymph node metastasis poses a problem to the clinician: it could be a delayed regional metastasis or a new metastasis from a yet unknown second primary tumor. Differentiation between metastasis and recurrence of primary tumors versus second primary tumor may be difficult because all lesions have the histologic appearance of SCC. Differentiation between these possibilities, however, carries important differences in therapeutic and prognostic consequences. In the following case report we present an unusually late regional lymph node metastasis in a patient who was treated 4 years earlier for an SCC in the inferior alveolar ridge. The purpose of the present study was to apply mitochondrial DNA D-loop analysis to assess the clonal relationship between oral tumor and node metastasis.
authors: Maxillofacial Surgery Unit, Policlinico S. Orsola-Malpighi, "Alma Mater Studiorum," University of Bologna, Bologna, Italy. Electronic address: achilletarsitano@gmail.com.
authors: Achille
authors: A
authors: Tarsitano
authors: Department of Hematology and Oncology, Section of Pathological Anatomy at Bellaria Hospital, University of Bologna, Bologna, Italy.
authors: Elisa
authors: E
authors: Leonardi
authors: Department of Hematology and Oncology, Section of Pathological Anatomy at Bellaria Hospital, University of Bologna, Bologna, Italy.
authors: Luca
authors: L
authors: Morandi
authors: Department of Hematology and Oncology, Section of Pathological Anatomy at Bellaria Hospital, University of Bologna, Bologna, Italy.
authors: Anna
authors: A
authors: Farnedi
authors: Department of Oral Science, "Alma Mater Studiorum," University of Bologna, Bologna, Italy.
authors: Lucio
authors: L
authors: Montebugnoli
authors: Maxillofacial Surgery Unit, Policlinico S. Orsola-Malpighi, "Alma Mater Studiorum," University of Bologna, Bologna, Italy.
authors: Claudio
authors: C
authors: Marchetti
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D004272:DNA, Mitochondrial / Q000032:analysis*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000235:genetics / Q000473:pathology*
chemical_list: D004272:DNA, Mitochondrial