title: Biodegradation study of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex composites.
abstract: Bone repair or regeneration is a common and complicated clinical problem in orthopedic surgery. The importance of natural polymers, such as microcrystalline chitosan, and minerals such as HAp and β-TCP, has grown significantly over the last two decades due to their renewable and biodegradable source, increasing the knowledge and functionality of composites in technological and biomedical applications. This study compares the biodegradation process, bioactivity, structure, morphology, and mechanical properties of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex; the latter according to the new method of preparation. The complex showed a homogeneous network structure with regular pores, good bioactivity, even after 60 days of conducting the hydrolytic and enzymatic degradation process, showing a bacteriostatic and bactericidal activity. The complex indicates that it could be used successfully as a base for implants and scaffolds production in orthopedic surgery.
authors: Institute of Biopolymers and Chemical Fibers-IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland.
authors: Luciano
authors: L
authors: Pighinelli
authors: Institute of Biopolymers and Chemical Fibers-IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland.
authors: Magdalena
authors: M
authors: Kucharska
authors: Institute of Biopolymers and Chemical Fibers-IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland.
authors: Maria
authors: M
authors: Wísniewska-Wrona
authors: Institute of Biopolymers and Chemical Fibers-IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland.
authors: Bogdan
authors: B
authors: Gruchała
authors: Institute of Biopolymers and Chemical Fibers-IBWCh, Sklodowskiej-Curie 19/27, Lodz, 90-570, Poland.
authors: Kinga
authors: K
authors: Brzoza-Malczewska
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development; D008422:Materials Testing; D016062:Porosity; D013211:Staphylococcus aureus / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D048271:Chitosan