title: Synthesis of taxane ABC tricyclic skeleton from lycoctonine.
abstract: A new conversional synthesis of the ABC ring system of taxoids from the C19-diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B, and opening of a four-membered ring.
authors: Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, Sichuan, PR China 610041.
authors: Xiao-Xia
authors: XX
authors: Liang
authors: Pei
authors: P
authors: Tang
authors: Qiao-Hong
authors: QH
authors: Chen
authors: Feng-Peng
authors: FP
authors: Wang
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry; D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D043823:Taxoids / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001952:Bridged-Ring Compounds; D004224:Diterpenes; D043823:Taxoids; C093992:lycoctonine; C080625:taxane; D000157:Aconitine