title: The assessment of long-term clinic and laboratory data of living related kidney donors.
abstract: Living-donor kidney transplantations are more common in Turkey. The present study, therefore, investigated the structural changes in the remaining kidney and their impacts on the outcomes of 71 donors who underwent nephrectomy. Among 123 screened living-donor transplantations performed between 2001 and 2008, information was available on 71. The study group included 37 female and 34 male donors with ages ranging between 20 and 68 years (mean, 45 ± 9 years). The donors had a median follow-up of 7.2 years. We investigated renal function and creatinine clearance as well as the presence of proteinuria and/or hypertension before versus after nephrectomy. Healthy individuals referred to our blood center were included as the control group. A comparison of pre- versus post-nephrectomy with control group data did not show any significant correlations between serum creatinine levels, creatinine clearances, and the presence of proteinuria relative to post-donation years. In contrast, we identified an increased prevalence of hypertension: Stage 1 in 4 patients before versus 22 subjects after nephrectomy. A key finding of this study was the slight increase in the number of hypertensive donors. Hypertension is, therefore, the most critical parameter to monitor donors in countries with a high proportion of living donors.
authors: Department of General Surgery, Sani Konukoğlu Hospital, Gaziantep, Turkey.
authors: N
authors: N
authors: Guvence
authors: K
authors: K
authors: Oskay
authors: D
authors: D
authors: Ayli
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016030:Kidney Transplantation / Q000009:adverse effects; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects; D011507:Proteinuria / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003404:Creatinine