title: Seizures with single therapeutic dose of isoniazid.
abstract: Isoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterised by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. A case of isoniazid induced seizures after therapeutic dose of 600 mg. as a part of CAT I thrice weekly intermittent anti-tuberculosis regimen for pulmonary tuberculosis is reported. The frequency of the usage of Isoniazid as antituberculosis therapy requires that physicians be aware of such toxicity.
authors: Department of Tuberculosis and Respiratory Diseases, LRS Institute of Tuberculosis and Respiratory Diseases, New Delhi. mmpuri@rediffmail.com
authors: M M
authors: MM
authors: Puri
authors: Lokender
authors: L
authors: Kumar
authors: P D
authors: PD
authors: Vishwakarma
authors: D
authors: D
authors: Behera
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000819:agonists*; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D012640:Seizures / Q000139:chemically induced*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid