title: Domestic animal models for biomedical research.
abstract: Experimental animals in biomedical research provide insights into disease mechanisms and models for determining the efficacy and safety of new therapies and for discovery of corresponding biomarkers. Although mouse and rat models are most widely used, observations in these species cannot always be faithfully extrapolated to human patients. Thus, a number of domestic species are additionally used in specific disease areas. This review summarizes the most important applications of domestic animal models and emphasizes the new possibilities genetic tailoring of disease models, specifically in pigs, provides.
authors: Chair for Molecular Animal Breeding and Biotechnology, Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.
authors: A
authors: A
authors: Bähr
authors: E
authors: E
authors: Wolf
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000502:physiology*; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D012098:Reproduction / Q000502:physiology