title: Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata.
abstract: A new resveratrol dimer, acuminatol (1), was isolated along with five known compounds from the acetone extract of the stem bark of Shorea acuminata. Their structures and stereochemistry were determined by spectroscopic methods, which included the extensive use of 2D NMR techniques. All isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (RSA) and the β-carotene-linoleic acid (BCLA) assays, and compared with those of the standards of ascorbic acid (AscA) and butylated hydroxytoluene (BHT). All compounds tested exhibited good to moderate antioxidant activity in the DPPH assay (IC₅₀s 0.84 to 10.06 mM) and displayed strong inhibition of β-carotene oxidation (IC₅₀s 0.10 to 0.22 mM). The isolated compounds were evaluated on the Vero cell line and were found to be non-cytotoxic with LC₅₀ values between 161 to 830 µM.
authors: School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, UKM Bangi 43600, Selangor D.E., Malaysia. norhayatimuhammad@ymail.com
authors: Norhayati
authors: N
authors: Muhammad
authors: Laily B
authors: LB
authors: Din
authors: Idin
authors: I
authors: Sahidin
authors: Siti Farah
authors: SF
authors: Hashim
authors: Nazlina
authors: N
authors: Ibrahim
authors: Zuriati
authors: Z
authors: Zakaria
authors: Wan A
authors: WA
authors: Yaacob
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002084:Butylated Hydroxytoluene / Q000737:chemistry; D002522:Chlorocebus aethiops; D053958:Dipterocarpaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D005609:Free Radicals / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D012015:Reference Standards; D013237:Stereoisomerism; D014709:Vero Cells; D019207:beta Carotene / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D006576:Heterocyclic Compounds, 4 or More Rings; D010851:Picrates; D010936:Plant Extracts; C576578:acuminatol; D019207:beta Carotene; D002084:Butylated Hydroxytoluene; C004931:1,1-diphenyl-2-picrylhydrazyl; D001205:Ascorbic Acid