title: Antiallergic effect of Picholine olive oil-in-water emulsions through β-hexosaminidase release inhibition and characterization of their physicochemical properties.
abstract: The inhibitory effect of Picholine olive oil from Montpellier in Southern France on the chemical mediator release in type I allergy, using rat basophilic leukemia (RBL-2H3) cells, was investigated. Oil-in-water (O/W) emulsions prepared using Picholine olive oil showed an inhibitory effect on the chemical mediator release and decreased expressions of genes related to type I allergy in RBL-2H3 cells. We then measured the phenolic compounds present in Picholine olive oil using high-performance liquid chromatography and investigated some physical properties, such as droplet size, size distribution, viscosity, and surface tension of the resulting olive O/W emulsions. Our findings indicate that Picholine olive oil has high flavonoids content, especially apigenin, and the prepared emulsion of Picholine olive oil resulted in a considerable small size distribution, with an average droplet size of 170 nm.
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. isoda.hiroko.ga@u.tsukuba.ac.jp
authors: Hiroko
authors: H
authors: Isoda
authors: Hideko
authors: H
authors: Motojima
authors: Delphine
authors: D
authors: Margout
authors: Marcos
authors: M
authors: Neves
authors: Junkyu
authors: J
authors: Han
authors: Mitsutoshi
authors: M
authors: Nakajima
authors: Michel
authors: M
authors: Larroque
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D047310:Apigenin / Q000032:analysis; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D004655:Emulsions; D005602:France; D006967:Hypersensitivity / Q000235:genetics; D015471:Leukemia, Basophilic, Acute; D047311:Luteolin / Q000032:analysis; D031658:Olea; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D059467:Transcriptome; D014867:Water / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors*
chemical_list: D018926:Anti-Allergic Agents; D004655:Emulsions; D000069463:Olive Oil; D010938:Plant Oils; D014867:Water; D047310:Apigenin; D001619:beta-N-Acetylhexosaminidases; D047311:Luteolin