title: Expression pattern of IQGAP1 in sinonasal inverted papillomas and squamous cell carcinomas.
abstract: OBJECTIVE
  The scaffold protein IQGAP1 is a ubiquitously expressed 190 kDa protein that participates in protein-protein interactions, integrating diverse signaling pathways. In this study, we examined the expression of IQGAP1 in sinonasal inverted papillomas (IP) and sinonasal squamous cell carcinomas (SCC), which include IP with SCC (IPcSCC) and SCC alone. We also tried to elucidate whether the amount of IQGAP1 expression is related with any clinicopathologic features of sinonasal SCCs.
  
  
  METHODS
  This was a retrospective study.
  
  
  METHODS
  The expression of IQGAP1 was analyzed by means of immunohistochemistry. The degrees of IQGAP1 expression and subcellular localization (rim formation) were analyzed with respect to the following clinicopathologic variables: age, gender, T stage, histologic differentiation, local recurrence, and distant metastasis.
  
  
  RESULTS
  The expression of IQGAP1 was significantly higher in patients with IPcSCC (3.62 ± 0.14), and SCC (2.93 ± 0.34) compared with IP (1.43 ± 0.26). The rim formation scale was significantly higher in IPcSCC (2.39 ± 0.24) compared with IP (1.68 ± 0.15). Distant metastasis in patients with SCC significantly correlated with an increased IQGAP1 rim formation (p = 0.011). Histologic differentiation was also significantly correlated with a positive staining scale for IQGAP1 in IPcSCCs (p = 0.038).
  
  
  CONCLUSIONS
  These results indicated that IQGAP1 expression is associated with both the histologic differentiation of IPcSCCs and is present in SCC cases where distant metastasis has occurred.
authors: Department of Otorhinolarynbgology-Head and Neck Surgery, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Jun
authors: J
authors: Jin
authors: Jin Woo
authors: JW
authors: Lee
authors: Ki-Sang
authors: KS
authors: Rha
authors: Dong Woon
authors: DW
authors: Kim
authors: Yong Min
authors: YM
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D018308:Papilloma, Inverted / Q000378:metabolism* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult; D020703:ras GTPase-Activating Proteins / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins