title: Pituitary stalk Langerhans cell histiocytosis treated with CyberKnife radiosurgery.
abstract: OBJECTIVE
  Langerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population.
  
  
  RESULTS
  We describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery.
  
  
  CONCLUSIONS
  The treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
authors: Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Wei-Chen
authors: WC
authors: Hong
authors: Judith A
authors: JA
authors: Murovic
authors: Iris
authors: I
authors: Gibbs
authors: Hannes
authors: H
authors: Vogel
authors: Steven D
authors: SD
authors: Chang
mesh_terms: D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D003919:Diabetes Insipidus / Q000150:complications; D016640:Diabetes, Gestational / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology / Q000601:surgery*; D020249:Hormone Replacement Therapy; D006801:Humans; D007031:Hypothalamus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009897:Optic Chiasm / Q000473:pathology; D010900:Pituitary Diseases / Q000473:pathology / Q000601:surgery*; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery*; D010907:Pituitary Hormones / Q000627:therapeutic use; D011141:Polyuria / Q000209:etiology; D011247:Pregnancy; D016634:Radiosurgery / Q000379:methods*; D013894:Thirst; D014794:Visual Fields / Q000502:physiology
chemical_list: D010907:Pituitary Hormones