title: Main extracts and hypolipidemic effects of the Bauhinia racemosa Lam. leaf extract in HFD-fed hamsters.
abstract: The lipid lowering effects of ethanolic extract (BR) obtained from leaves of Bauhinia racemosa on hyperlipidemic hamsters were examined. BR showed significant lowering of lipid profile at a dose of 250 mg kg(-1) body-wt of hamster. Chloroform fraction (F2) obtained from BR showed pronounced activity at lower dose of 100 mg kg(-1). F2 gave two most active fractions (L and T) whose chromatographic separations led to the isolation of constituents 1-5, which are being reported for the first time from this natural source. The results of activity profile of the plant were found to be better than the standard drug lovastatin.
authors: Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow - 226001, Uttar Pradesh, India. sashidhar123@gmail.com
authors: Koneni V
authors: KV
authors: Sashidhara
authors: Suriya P
authors: SP
authors: Singh
authors: Anuj
authors: A
authors: Srivastava
authors: Anju
authors: A
authors: Puri
mesh_terms: D000818:Animals; D036481:Bauhinia / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry; D006224:Cricetinae; D059305:Diet, High-Fat / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008148:Lovastatin / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D012855:Sitosterols / Q000032:analysis
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts; D012855:Sitosterols; D002725:Chloroform; D008148:Lovastatin; C011015:lyoniside