title: Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury.
abstract: The default mode network (DMN) is a reliably elicited functional neural network with potential clinical implications. Its discriminant and prognostic utility following traumatic axonal injury (TAI) have not been previously investigated. The present study used three approaches to analyze DMN functional connectedness, including a whole-brain analysis [A1], network-specific analysis [A2], and between-node (edge) analysis [A3]. The purpose was to identify the utility of each method in distinguishing between healthy and brain-injured individuals, and determine whether observed differences have clinical significance. Resting-state fMRI was acquired from 25 patients with TAI and 17 healthy controls. Patients were scanned 6-11 months post-injury, and functional and neurocognitive outcomes were assessed the same day. Using all three approaches, TAI subjects revealed significantly weaker functional connectivity (FC) than controls, and binary logistic regressions demonstrated all three approaches have discriminant value. Clinical outcomes were not correlated with FC using any approach. Results suggest that compromise to the functional connectedness of the DMN after TAI can be identified using resting-state FC; however, the degree of functional compromise to this network, as measured in this study, may not have clinical implications in chronic TAI.
authors: Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Ana
authors: A
authors: Arenivas
authors: Ramon
authors: R
authors: Diaz-Arrastia
authors: Jeffrey
authors: J
authors: Spence
authors: C Munro
authors: CM
authors: Cullum
authors: Kamini
authors: K
authors: Krishnan
authors: Christopher
authors: C
authors: Bosworth
authors: Carlee
authors: C
authors: Culver
authors: Beth
authors: B
authors: Kennard
authors: Carlos
authors: C
authors: Marquez de la Plata
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation; D001931:Brain Mapping / Q000379:methods; D002908:Chronic Disease; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D012146:Rest; D012815:Signal Processing, Computer-Assisted; D016896:Treatment Outcome