title: Effects of inhaled fluticasone on intraocular pressure and central corneal thickness in asthmatic children without a family history of glaucoma.
abstract: OBJECTIVE
  The aim of this study is to report the effects of fluticasone-inhaled corticosteroid on intraocular pressure (IOP) and central corneal thickness (CCT) of asthmatic children without a family history of glaucoma.
  
  
  METHODS
  In this prospective study, 93 children were divided into two groups: 69 asthmatic children with no family history of glaucoma who were taking inhaled fluticasone propionate 250 μg daily for at least 6 months (Group 1) and 24 age-matched control subjects without asthma (Group 2). Three measurements each, of IOP and CCT, were performed with a hand-held noncontact tonometer and a noncontact specular microscope, respectively, over a 12-week period. The order of IOP and CCT measured were randomized at each visit. Between-group comparison and the relationship between CCT and IOP measurements were investigated. P < 0.05 was statistically significant.
  
  
  RESULTS
  The mean age was 8 ± 2.4 years (range, 5-15 years) and 9 ± 2.9 years (range, 5-15 years) for Groups 1 and 2, respectively (P = 0.1337). The mean IOP was 14 ± 3.3 mmHg (range, 10-24 mmHg) and 14 ± 2.9 mmHg (range, 11-22 mmHg) for Groups 1 and 2, respectively (P = 0.3626). The mean CCT was 531 ± 30.1 μm (range, 467-601 μm) and 519 ± 47.0 μm (range, 415589 μm) for Groups 1 and 2, respectively (P = 0.1625). There was a weak but statistically significant correlation between IOP and CCT in Group 1 (Pearson's R = 0.3580, P = 0.0025).
  
  
  CONCLUSIONS
  Inhaled fluticasone at the regular dose used in this study over a short period (6-24 months) was not associated with a significant effect on CCT and IOP measured with noncontact devices in asthmatic children between 5 and 15 years, without a family history of glaucoma. A weak correlation between IOP and CCT values in asthmatic children did exist.
authors: Department of Pediatrics, College of Medicine, King Khalid University Hospital, King Saud University.
authors: Muslim M
authors: MM
authors: Alsaadi
authors: Uchechukwu L
authors: UL
authors: Osuagwu
authors: Turki M
authors: TM
authors: Almubrad
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000730:Androstadienes / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D000068298:Fluticasone; D005500:Follow-Up Studies; D005901:Glaucoma / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D033401:Microscopy, Acoustic; D009798:Ocular Hypertension / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012529:Saudi Arabia / Q000453:epidemiology; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular
chemical_list: D000730:Androstadienes; D001993:Bronchodilator Agents; D000068298:Fluticasone