title: Increased interleukin-8 in epithelial lining fluid of collapsed lungs during one-lung ventilation for thoracotomy.
abstract: The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung tumors. The samples were taken after induction of anesthesia (baseline), 30 min after one-lung ventilation was started (point 2), just before resuming two-lung ventilation (point 3), and 30 min after two-lung ventilation was restarted (point 4). The albumin and IL-8 concentrations in ELF were significantly increased at point 2 and point 3, respectively, and remained to be high, compared to the baseline. The increase in IL-8 at point 3 was correlated with the interval of one-lung ventilation; however, none developed specific acute lung injury. These findings suggest that inflammatory changes can occur on the epithelium of a collapsed lung even in patients who underwent successful and standard thoracic surgery.
authors: First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: Yoshimichi
authors: Y
authors: Komatsu
authors: Hiroshi
authors: H
authors: Yamamoto
authors: Kenji
authors: K
authors: Tsushima
authors: Shino
authors: S
authors: Furuya
authors: Sumiko
authors: S
authors: Yoshikawa
authors: Masanori
authors: M
authors: Yasuo
authors: Keishi
authors: K
authors: Kubo
authors: Yoshitaka
authors: Y
authors: Yamazaki
authors: Joh
authors: J
authors: Hasegawa
authors: Takashi
authors: T
authors: Eguchi
authors: Ryuichi
authors: R
authors: Kondo
authors: Kazuo
authors: K
authors: Yoshida
authors: Tomonobu
authors: T
authors: Koizumi
mesh_terms: D000368:Aged; D000418:Albumins / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism*; D008168:Lung / Q000276:immunology; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation; D001261:Pulmonary Atelectasis / Q000276:immunology / Q000378:metabolism*; D011654:Pulmonary Edema / Q000276:immunology; D020545:Respiratory Mucosa / Q000276:immunology* / Q000378:metabolism; D013908:Thoracotomy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000418:Albumins; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha