title: Evaluation of flavonoid and resveratrol chemical libraries reveals abyssinone II as a promising antibacterial lead.
abstract: Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).
authors: Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA. dianqing@hawaii.edu
authors: Dianqing
authors: D
authors: Sun
authors: Julian G
authors: JG
authors: Hurdle
authors: Robin
authors: R
authors: Lee
authors: Richard
authors: R
authors: Lee
authors: Mark
authors: M
authors: Cushman
authors: John M
authors: JM
authors: Pezzuto
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D000077185:Resveratrol; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D005419:Flavonoids; D054852:Small Molecule Libraries; D013267:Stilbenes; C511702:abyssinone II; D000077185:Resveratrol