title: Effect of ion-bombarded silicone tympanostomy tube on ciprofloxacin-resistant Pseudomonas aeruginosa biofilm formation.
abstract: OBJECTIVE
  Many materials and surface preparations have been developed to resist the formation of biofilm. Ion-bombarded silicone tympanostomy tube was introduced to resist both staphylococcal and pseudomonal biofilm formation. To date, there are no reports that have evaluated the use of ion-bombarded tympanostomy tubes against the ciprofloxacin-resistant Pseudomonas aeruginosa (CRPA) biofilm formation. The purpose of this study is to evaluate the ion-bombarded tympanostomy tube for CRPA biofilm resistance.
  
  
  METHODS
  Commercial ion-bombarded tympanostomy tubes and simple silicone tympanostomy tubes were processed for an evaluation of the CRPA biofilm formation in vitro.
  
  
  RESULTS
  The ion-bombarded tubes showed no resistance to CRPA adhesion and biofilm formation. Thick and dense conglomeration was less formed in the ion-bombarded tympanostomy tubes, compared to that of the simple silicone tube.
  
  
  CONCLUSIONS
  The preventive effect against the CRPA biofilm formation of the ion-bombarded silicone tympanostomy tube was not observed. Our result suggests that only the surface modification by an ion bombardment is not enough to resist CRPA biofilm formation.
authors: Department of Otolaryngology, Chonnam National University Medical School, Gwangju, Republic of Korea. chulsavio@hanmail.net
authors: Chul Ho
authors: CH
authors: Jang
authors: Yong Beom
authors: YB
authors: Cho
authors: Cheol Hee
authors: CH
authors: Choi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D002939:Ciprofloxacin / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D024881:Drug Resistance, Bacterial; D004866:Equipment Contamination / Q000517:prevention & control; D006801:Humans; D008422:Materials Testing; D008876:Middle Ear Ventilation / Q000295:instrumentation*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology*; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012828:Silicones; D002939:Ciprofloxacin