title: Nanofluidic devices towards single DNA molecule sequence mapping.
abstract: Nanofluidics enables the imaging of stretched single molecules with potential applications for single molecule sequence mapping. Lab-on-a-chip devices for single cell trapping and lyzing, genomic DNA extraction from single cells, and optical mapping of genomic length DNA has been demonstrated separately. Yet the pursuit for applying DNA optical mapping to solve real genomics challenges is still to come. We review lab-on-a-chip devices from literature that could be part of a complete system for the sequence mapping of single DNA molecules.
authors: Department of micro- and nanotechnology, Technical University of Denmark, Oersteds plads Building 345east, 2800 Kongens Lyngby, Denmark. Rodolphe.Marie@nanotech.dtu.dk.
authors: Rodolphe
authors: R
authors: Marie
authors: Anders
authors: A
authors: Kristensen
mesh_terms: D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D023281:Genomics; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D061848:Optical Imaging; D017422:Sequence Analysis, DNA / Q000295:instrumentation*
chemical_list: D004247:DNA