title: Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of life thread.
abstract: Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis. Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis. Unswervingly, these elements constitute a recently explored 'network of networks' that dynamically reorganizes during DNA damage and is responsible for positively or negatively regulating genome organization and integrity. We consider these facets of convergence and discuss how insights from diametrically opposed interactions of ataxia-telangiectasia mutated and mitrons can inform us about, and possibly help us to get a step closer to personalized medicine.
authors: Lab for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan. ammadahmad638@yahoo.com
authors: Ammad Ahmad
authors: AA
authors: Farooqi
authors: Ali
authors: A
authors: Naqi
authors: Muhammad Zahid
authors: MZ
authors: Qureshi
authors: Aamir
authors: A
authors: Rana
authors: Ammara
authors: A
authors: Khan
authors: Asma M
authors: AM
authors: Riaz
authors: Syed Muhammad Faheem
authors: SM
authors: Afzal
authors: Nabeelah
authors: N
authors: Rasheed
authors: Shahzad
authors: S
authors: Bhatti
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015291:Transforming Growth Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D035683:MicroRNAs; D025521:Tumor Suppressor Proteins; D015291:Transforming Growth Factors; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases