title: [Changes in the proteasome function after induction of donor-specific tolerance in rats with ovarian allograft].
abstract: Induction of donor-specific tolerance in a recipient is one of the methods for enhancing acceptance of the grafts of endocrine glands in the absence of immunodepressants, which interfere with hormone production. This paper describes changes in the proteasome pool in the rat liver, spleen, and graft during the development of donor-specific tolerance after intraportally infusing the recipient with donor splenocytes with subsequent allografting of ovarian tissue into the renal capsule. It has been demonstrated that the shift in the balance in the liver and graft proteasome pools towards the variants with the LMP2 subunit determines the development of immunological tolerance and graft retention. On the contrary, an increase in the forms with the LMP7 subunit induces the immune response and graft rejection.
authors: Ia D
authors: IaD
authors: Karpova
authors: G A
authors: GA
authors: Bozhok
authors: Iu V
authors: IuV
authors: Liupina
authors: E I
authors: EI
authors: Legach
authors: T M
authors: TM
authors: Astakhova
authors: A A
authors: AA
authors: Stepanova
authors: T P
authors: TP
authors: Bondarenko
authors: N P
authors: NP
authors: Sharova
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D007108:Immune Tolerance / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D010052:Ovariectomy; D010053:Ovary / Q000637:transplantation*; D011374:Progesterone / Q000097:blood; D046988:Proteasome Endopeptidase Complex / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D014184:Transplantation, Homologous / Q000276:immunology*
chemical_list: C071313:LMP-2 protein; D011374:Progesterone; D004958:Estradiol; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex