title: A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin.
abstract: The interaction of Cu(2+) with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1-16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion. Complexes between Aβ(1-16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu(2+) is involved in Aβ(1-16) aggregation. The indexes of stability indicate that HSA removed Cu(2+) from Aβ(1-16), rapidly, decreased Cu-induced aggregation of Aβ(1-16), and reduced the toxicity of Aβ(1-16) + Cu(2+) significantly.
authors: Chemistry Department, Imam Khomeini International University, Qazvin 34149-16818, Iran.
authors: G Rezaei
authors: GR
authors: Behbehani
authors: L
authors: L
authors: Barzegar
authors: M
authors: M
authors: Mohebbian
authors: A A
authors: AA
authors: Saboury