title: Prospective testing of mucoepidermoid carcinoma for the MAML2 translocation: clinical implications.
abstract: OBJECTIVE
  Mucoepidermoid carcinoma (MEC) with MAML2 translocation is believed to be associated with lower clinical stage, lower histologic grade, and better outcome. We summarized our prospective experience testing MEC for the MAML2 translocation.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  One hundred eighteen head and neck tumors (55 MECs and 63 mimics) were prospectively tested for MAML2 translocation by fluorescence in situ hybridization as part of clinical care during a 36-month period.
  
  
  RESULTS
  MAML2 translocation was identified in 41 of 55 (75%) cases diagnosed as MEC. Translocation status did not correlate significantly with histologic grade, age, gender, tumor site, or T stage.
  
  
  CONCLUSIONS
  Routine testing for MAML2 translocation by fluorescence in situ hybridization is feasible and useful in confirming the diagnosis of MEC. The lack of significant correlation with histologic grade or pathologic stage implies that the previously reported prognostic value of the MAML2 translocation may be an artifact of misclassification of MEC as other tumors.
authors: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. chioseasi@upmc.edu
authors: Simion I
authors: SI
authors: Chiosea
authors: Sanja
authors: S
authors: Dacic
authors: Marina N
authors: MN
authors: Nikiforova
authors: Raja R
authors: RR
authors: Seethala
mesh_terms: D044963:Biopsy, Fine-Needle; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000235:genetics*; D010039:Otorhinolaryngologic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors