title: HIV-1 diseases progression associated with loss of Th17 cells in subtype 'C' infection.
abstract: Th17 cells play a crucial role in host immune response. We examined the role of Th17 cells in HIV-1 'subtype-C' infection and report that HIV-1 specific Th17 cells are induced in early infection and slow progressors but are significantly reduced at late stage of infection. There was a further decline in Th17 cells in late stage subjects with gastrointestinal infections. Additionally, we observed expanded population of IL-21 (needed for Th17 population expansion) producing CD4 T cells in early and slow progressors compared to subjects with late stage infection. A significant positive correlation existed between virus specific IL-17 and IL-21 producing CD4 T cells suggesting that HIV-1 infection induces a demand for Th17 cells. A significant negative correlation between virus specific Th17 cells and HIV-1 plasma viral load (pVL) was also observed, indicating a gradual loss of Th17 cells with HIV-1 disease progression.
authors: HIV & Immunology Division, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India. alpana31748@rediffmail.com
authors: Alpana
authors: A
authors: Singh
authors: Madhu
authors: M
authors: Vajpayee
authors: Sharique A
authors: SA
authors: Ali
authors: Kamalika
authors: K
authors: Mojumdar
authors: Neeraj Kumar
authors: NK
authors: Chauhan
authors: Ravinder
authors: R
authors: Singh
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D008297:Male; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D013997:Time Factors; D019562:Viral Load / Q000276:immunology; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000276:immunology; D000098546:Interleukin-21
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D054301:gag Gene Products, Human Immunodeficiency Virus; D000098546:Interleukin-21