title: Nonalcoholic fatty liver disease is associated with atherosclerosis in middle-aged and elderly Chinese.
abstract: OBJECTIVE
  To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.
  
  
  RESULTS
  A total of 8632 participants aged ≥ 40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30.0% in the total population, with 30.3% in men and 29.9% in women, respectively. Subjects with NAFLD had remarkably higher CIMT and ba-PWV compared with those without NAFLD (0.594 ± 0.105 mm versus 0.578±0.109 mm, P<0.0001; 1665 ± 424 cm/s versus 1558 ± 430 cm/s, P<0.0001). Subjects with both NAFLD and metabolic syndrome had significantly higher CIMT and ba-PWV compared with those with neither or either of these 2 diseases after adjustment for age and sex (all P<0.05). Logistic regressions also revealed that NAFLD conferred 35% and 30% increased odds ratios of elevated CIMT and ba-PWV, independent of conventional risk factors and the presence of metabolic syndrome.
  
  
  CONCLUSIONS
  NAFLD was associated with elevated CIMT and ba-PWV, independent of conventional cardiovascular disease risk factors and metabolic syndrome. The effects of NAFLD and metabolic syndrome on atherosclerosis might not fully overlap.
authors: Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors: Yun
authors: Y
authors: Huang
authors: Yufang
authors: Y
authors: Bi
authors: Min
authors: M
authors: Xu
authors: Zhimin
authors: Z
authors: Ma
authors: Yu
authors: Y
authors: Xu
authors: Tiange
authors: T
authors: Wang
authors: Mian
authors: M
authors: Li
authors: Yu
authors: Y
authors: Liu
authors: Jieli
authors: J
authors: Lu
authors: Yuhong
authors: Y
authors: Chen
authors: Fei
authors: F
authors: Huang
authors: Baihui
authors: B
authors: Xu
authors: Jie
authors: J
authors: Zhang
authors: Weiqing
authors: W
authors: Wang
authors: Xiaoying
authors: X
authors: Li
authors: Guang
authors: G
authors: Ning
mesh_terms: D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D055109:Ankle Brachial Index; D044466:Asian People / Q000706:statistics & numerical data*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000208:ethnology* / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000208:ethnology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors