title: Salivary high-sensitivity cardiac troponin T levels in patients with acute myocardial infarction.
abstract: OBJECTIVE
  Accurate and rapid diagnosis of acute myocardial infarction (MI) is of major medical and economic importance. The objective of this study was to identify whole saliva high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute MI.
  
  
  METHODS
  A case-control study was carried out in 30 normal healthy individuals, and 30 patients with acute MI were hospitalized in CCU of Imam Hossein hospital, Tehran, Iran. The hs-cTnT levels were assayed in serum and whole saliva in the first and second morning following the MI by ELISA method. Statistical analysis of the Student's t-test and Pearson correlation coefficient was performed.
  
  
  RESULTS
  The mean stimulated and unstimulated saliva and serum levels of hs-cTnT at both the first and the second morning following the acute MI were significantly higher in patients with acute MI compared with healthy individuals. Furthermore, stimulated and unstimulated saliva hs-TnT levels correlated significantly with serum hs-TnT level (r = 0.415, P < 0.023; r = 0.466, P < 0.021, respectively).
  
  
  CONCLUSIONS
  Results suggest that salivary hs-cTnT can be used as an alternative to serum hs-cTnT for diagnosis and monitoring of myocardial infarction.
authors: Department of Physiology, Physiology in Unusual States Research Center, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
authors: I
authors: I
authors: Mirzaii-Dizgah
authors: E
authors: E
authors: Riahi
mesh_terms: D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000032:analysis*
chemical_list: D020107:Troponin T