title: Transcription, splicing, and release: are we there yet?
abstract: A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.
authors: Laboratory of Molecular Biology and Immunology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA. ranjan.sen@nih.gov
authors: Ranjan
authors: R
authors: Sen
authors: Sebastian D
authors: SD
authors: Fugmann