title: [Therapy of castration-resistant prostate cancer].
abstract: Within the last two years the therapy of castration resistant prostate cancer (CRPC) has made major advances. Both the COU-AA-301 phase III trial and the TROPIC trial showed a survival benefit for patients after docetaxel failure treated with abiraterone or cabazitaxel, respectively. With rising interest for chemotherapeutic options and novel drugs, our goal was to review within the context of a multidisciplinary team the available evidence and explore the standards for medical treatment of prostate cancer outside of clinical trials. From this background, we are carefully evaluating the current treatment recommendations, based on the available evidence, and highlight potential future treatment options but also discuss important clinical topics like treatment until progression versus the advantage of chemo holidays and definition of particular patient subgroups. Additionally, we focus on novel molecular entities, which will most likely be available in the near future, such as MDV3100 and Sipuleucel T. The role and importance of palliation with radiotherapy and proactive medical management of pain is also discussed, as well as new options for bone directed therapy. The multitude of treatment options for patients with advanced prostate cancer clearly asks for a close collaboration between urologists, medical oncologists and radiation therapists.
authors: Urologische Abteilung, Donauspital, Wien, Österreich.
authors: Michael
authors: M
authors: Rauchenwald
authors: Thomas
authors: T
authors: Bauernhofer
authors: Maria
authors: M
authors: De Santis
authors: Thorsten
authors: T
authors: Füreder
authors: Wolfgang
authors: W
authors: Höltl
authors: Gero
authors: G
authors: Kramer
authors: Steffen
authors: S
authors: Krause
authors: Wolfgang
authors: W
authors: Loidl
authors: Renée
authors: R
authors: Oismüller
authors: Andreas
authors: A
authors: Reissigl
authors: Nikolaus
authors: N
authors: Schmeller
authors: Walter
authors: W
authors: Stackl
authors: Franz
authors: F
authors: Stoiber
authors: Michael
authors: M
authors: Krainer
mesh_terms: D002369:Castration; D004358:Drug Therapy / Q000592:standards*; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011471:Prostatic Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant / Q000592:standards*; D017211:Treatment Failure