title: Short-term prognostic value of serum neuron specific enolase and S100B in acute stroke patients.
abstract: OBJECTIVE
  To explore the value of blood markers for brain injury as outcome predictors in acute stroke.
  
  
  METHODS
  The study included 61 patients with acute stroke (44 ischemic and 17 hemorrhagic) and a high risk control group (79 individuals with no known history of neurological disease). Serum neuron specific enolase (NSE) and S100B were determined by immunoassay (CanAg Diagnostics, Sweden). Outcome at 60 days was evaluated with clinical scales.
  
  
  RESULTS
  Higher concentrations of NSE and S100B were measured in patients compared to high risk controls, but they were not related to stroke severity on admission. NSE was associated with functional neurological outcome at 60 days and to the degree of recovery, whereas S100B exhibited a strong correlation with depression symptoms at 60 days.
  
  
  CONCLUSIONS
  The measurements of serum concentrations of NSE and S100B after acute stroke may be clinically relevant for predicting functional neurological outcome and post-stroke depression, respectively.
authors: Institute of Neurology and Neurosurgery, Havana, Cuba. sergiogg@infomed.sld.cu
authors: Sergio
authors: S
authors: González-García
authors: Alina
authors: A
authors: González-Quevedo
authors: Otman
authors: O
authors: Fernández-Concepción
authors: Marisol
authors: M
authors: Peña-Sánchez
authors: Caridad
authors: C
authors: Menéndez-Saínz
authors: Zenaida
authors: Z
authors: Hernández-Díaz
authors: Marianela
authors: M
authors: Arteche-Prior
authors: Alejandro
authors: A
authors: Pando-Cabrera
authors: Carlos
authors: C
authors: Fernández-Novales
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D003863:Depression / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D012372:ROC Curve; D012044:Regression Analysis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase