title: MagnetofectionTM platform: from magnetic nanoparticles to novel nucleic acid therapeutics.
abstract: Nucleic acid delivery to cells to make them produce a desired protein or to shut down the expression of endogenous genes opens unique possibilities for research and therapy. During the last decade, to realize the potential of this approach, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as Magnetofection. Our research group at the Institute of Experimental Oncology and Therapy Research, located at the University Hospital Klinikum rechts der Isar in the center of Munich, Germany, develops new magnetic nanomaterials and, their formulations with gene-delivery vectors and technologies to allow localized and efficient gene delivery in vitro and in vivo for a variety of research, diagnostic and therapeutic applications.
authors: Institute of Experimental Oncology and Therapy Research, Klinikum rechts der Isar, Technical University Munich, Germany. plank@lrz.tum.de
authors: Christian
authors: C
authors: Plank
authors: Dialechti
authors: D
authors: Vlaskou
authors: Ulrike
authors: U
authors: Schillinger
authors: Olga
authors: O
authors: Mykhaylyk
mesh_terms: D000256:Adenoviridae / Q000378:metabolism; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods* / Q000662:veterinary; D005822:Genetic Vectors / Q000378:metabolism; D006801:Humans; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D023822:Tissue Engineering / Q000379:methods; D000818:Animals