title: Draft genome sequence of Streptomyces globisporus C-1027, which produces an antitumor antibiotic consisting of a nine-membered enediyne with a chromoprotein.
abstract: Streptomyces globisporus C-1027 is the producer of antitumor antibiotic C-1027, a nine-membered enediyne-containing compound. Here we present a draft genome sequence of S. globisporus C-1027 containing the intact biosynthetic gene cluster for this antibiotic. The genome also carries numerous sets of genes for the biosynthesis of diverse secondary metabolites.
authors: Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Lifei
authors: L
authors: Wang
authors: Songmei
authors: S
authors: Wang
authors: Qing
authors: Q
authors: He
authors: Tengfei
authors: T
authors: Yu
authors: Qinglian
authors: Q
authors: Li
authors: Bin
authors: B
authors: Hong
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D053898:Biosynthetic Pathways / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D053281:Enediynes / Q000378:metabolism*; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D005810:Multigene Family; D017422:Sequence Analysis, DNA; D013302:Streptomyces / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D053281:Enediynes; C029136:antitumor protein, Streptomyces