title: Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits.
abstract: Oxygen tension (PO(2)) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, ΔPO(2) (i.e., hyperoxic PO(2) minus baseline PO(2)) was computed. Compared to the conscious state, brain ΔPO(2) increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension.
authors: Center for Basic MR Research, Department of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
authors: Daniil
authors: D
authors: Aksenov
authors: Joshua E
authors: JE
authors: Eassa
authors: Janesh
authors: J
authors: Lakhoo
authors: Alice
authors: A
authors: Wyrwicz
authors: Robert A
authors: RA
authors: Linsenmeier
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D002560:Cerebrovascular Circulation; D005260:Female; D006706:Homeostasis; D007530:Isoflurane / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood / Q000502:physiology*; D011312:Pressure; D011817:Rabbits
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane; D010100:Oxygen