title: Disappearance of an activated EGFR mutation after treatment with EGFR tyrosine kinase inhibitors.
abstract: A 34-year-old Japanese woman presented with left supraclavicular lymph node swelling. Computed tomography scans revealed a mass on the left lower lobe, pulmonary nodules, and pleural effusion. A lymph node biopsy revealed large-cell carcinoma with an epidermal growth factor receptor (EGFR) deletion mutation, L747-T751 in exon 19. Although malignant pleural effusions carried the same EGFR mutation, progressive pleural effusions after treatment with chemotherapy, gefitinib, and erlotinib did not show any EGFR mutation. A cell line established from the pleural effusion 3 days before the patient expired also did not harbor the EGFR mutation. Histological sections of the lymph node of the patient were similar to those of the xenograft tumor of the cell line. There may be genetic heterogeneity in EGFR mutant tumors.
authors: Department of Respiratory Medicine, Okayama University Hospital, Japan.
authors: Yoshihiro
authors: Y
authors: Honda
authors: Nagio
authors: N
authors: Takigawa
authors: Soichiro
authors: S
authors: Fushimi
authors: Nobuaki
authors: N
authors: Ochi
authors: Toshio
authors: T
authors: Kubo
authors: Saeko
authors: S
authors: Ozaki
authors: Mitsune
authors: M
authors: Tanimoto
authors: Katsuyuki
authors: K
authors: Kiura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005091:Exons; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D009154:Mutation; D009367:Neoplasm Staging; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors