title: Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI.
abstract: Levels of four urinary F(2)-isoprostanes (F(2)-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic whites (NHWs), and 275 Hispanic whites (HWs). F(2)-IsoP isomers - iPF2a-III, 2,3-dinor-iPF2a-III, iPF2a-VI, and 8,12-iso-iPF2a-VI - were measured in 854 urine samples using liquid chromatography with tandem mass spectrometry detection. In AAs, levels of all four F(2)-IsoPs were lower compared with NHWs and HWs (P values <0.05). When stratified by BMI, this gap was not observed among participants with normal BMI but appeared among overweight participants and increased among obese participants. Examining the slopes of the associations between BMI and F(2)-IsoPs showed no association between these variables among AAs (P values >0.2), and positive associations among whites (P values <0.05). Taking into account that positive cross-sectional associations between systemic F(2)-IsoP levels and BMI have been consistently demonstrated in many study populations, the lack of such an association among AAs reveals a new facet of racial/ethnic differences in obesity-related risk profiles.
authors: Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA. dora.ilyasova@duke.edu
authors: Dora
authors: D
authors: Il'yasova
authors: Frances
authors: F
authors: Wang
authors: Ivan
authors: I
authors: Spasojevic
authors: Karel
authors: K
authors: Base
authors: Ralph B
authors: RB
authors: D'Agostino
authors: Lynne E
authors: LE
authors: Wagenknecht
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D050197:Atherosclerosis / Q000208:ethnology / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000652:urine*; D028441:F2-Isoprostanes / Q000652:urine*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000208:ethnology* / Q000652:urine*; D018384:Oxidative Stress; D011446:Prospective Studies; D053719:Tandem Mass Spectrometry; D014481:United States / Q000453:epidemiology; D015430:Weight Gain; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes