title: [Corneal toxicity due to amantadine].
abstract: METHODS
  A 64 year-old female with Parkinson disease treated with amantadine for two years who suddenly suffered bilateral corneal oedema. It was initially treated as herpetic endotheliitis without improvement as we lacked information on her chronic treatment. The corneal oedema finally resolved after withdrawing the drug.
  
  
  CONCLUSIONS
  Amantadine hydrochloride may produce endothelial dysfunction. Once the amantadine treatment is stopped, the corneal oedema may be reversible but endothelial density remains low. An ophthalmologist examination should be performed before the initiation of amantadine treatment in order to establish a risk: benefit ratio, especially in those patients with low endothelial density or any endothelial anomaly.
authors: Servicio de Oftalmología, Complejo Hospitalario La Mancha-Centro, Alcázar de San Juan, Ciudad Real, España. cataeva@hotmail.com
authors: E M
authors: EM
authors: Avendaño-Cantos
authors: J
authors: J
authors: Celis-Sánchez
authors: D
authors: D
authors: Mesa-Varona
authors: J
authors: J
authors: Gálvez-Martínez
authors: E
authors: E
authors: López-Arroquia
authors: F
authors: F
authors: González Del Valle
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000547:Amantadine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism; D002387:Cataract Extraction; D002442:Ceftazidime / Q000627:therapeutic use; D015715:Corneal Edema / Q000139:chemically induced* / Q000188:drug therapy; D055954:Corneal Endothelial Cell Loss / Q000139:chemically induced; D003318:Corneal Opacity / Q000139:chemically induced*; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007634:Keratitis / Q000175:diagnosis; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D011183:Postoperative Complications / Q000139:chemically induced; D011239:Prednisolone / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000978:Antiparkinson Agents; D012462:Saline Solution, Hypertonic; D014640:Vancomycin; D002442:Ceftazidime; D011239:Prednisolone; D000547:Amantadine; D000212:Acyclovir