title: Syndecan and integrin interactomes: large complexes in small spaces.
abstract: The syndecan family of transmembrane proteoglycans cooperate with integrins to regulate both early and late events in adhesion formation. The heparan sulphate chains substituted on to the syndecan ectodomains are capable of engaging ligands over great distance, while the protein core spans the plasma membrane and initiates cytoplasmic signals through a short cytoplasmic tail. These properties create a spatial paradox. The volume of the heparan sulphate chains greatly exceeds that of the integrins with which it cooperates, while the short cytodomain must bind to multiple cytoplasmic factors, despite being long enough to bind only one or two. In this review we consider the structural rearrangements that a cell undertakes to overcome spatial restrictions and compare the interactomes of syndecans and integrins to gain insight into the composition of adhesions and how they are regulated over time.
authors: School of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom.
authors: James A
authors: JA
authors: Roper
authors: Rosalind C
authors: RC
authors: Williamson
authors: Mark D
authors: MD
authors: Bass
mesh_terms: D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D011485:Protein Binding; D060066:Protein Interaction Maps; D053667:Syndecans / Q000378:metabolism*
chemical_list: D016023:Integrins; D053667:Syndecans