title: Statin use and the risk of bladder cancer: a population-based case-control study.
abstract: OBJECTIVE
  The aim of this study was to investigate whether the use of statins is associated with bladder cancer risk.
  
  
  METHODS
  The authors conducted a population-based case-control study in Taiwan. Cases consisted of all patients who were aged 50 years and older and had a first-time diagnosis of bladder cancer, for the period between 2004 and 2010. The controls were matched to cases by age, sex and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multiple logistic regression.
  
  
  RESULTS
  The authors examined 325 bladder cancer cases and 1300 controls. The unadjusted ORs for any statin prescription was 0.94 (95% CI 0.70 - 1.28) and the adjusted OR was 0.88 (95% CI 0.61 - 1.25). Compared with no use of statins, the adjusted ORs were 0.72 (95% CI 0.40 - 1.28) for the group having been prescribed statins with cumulative defined daily dose (DDDs) below 56 DDDs, 0.81 (95% CI 0.46 - 1.43) for the group with cumulative dose between 56 DDDs and 196 DDDs, and 1.11 (95% CI 0.67 - 1.85) for the group with cumulative statin use of 196 DDDs or more.
  
  
  CONCLUSIONS
  The present data do not provide evidence to support either beneficial or harmful associations between statin use and bladder cancer risk.
authors: Kaohsiung Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Division of Nephrology, Department of Internal Medicine, Kaohsiung, Taiwan.
authors: Chien-Chun
authors: CC
authors: Kuo
authors: Hui-Fen
authors: HF
authors: Chiu
authors: I-Ming
authors: IM
authors: Lee
authors: Hsin-Wei
authors: HW
authors: Kuo
authors: Chien-Te
authors: CT
authors: Lee
authors: Chun-Yuh
authors: CY
authors: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D011307:Drug Prescriptions; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D060735:Pharmacovigilance; D012306:Risk; D013624:Taiwan / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors