title: The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats.
abstract: The objective of this research was to study the ameliorative effects of a standardized quassinoid-rich extract (TAF 273) of Eurycoma longifolia root on some reproductive disorders in female rats. An irregular estrous cycle and ovarian cystic follicles were induced in 21-day-old females by the daily administration of testosterone (10 mg/kg, sc) for three weeks. The hormone-treated rats exhibited persistent diestrous as well as ovaries containing cystic follicles. Upon treatment with TAF 273, fewer animals showed irregular estrous cycles and there was less follicular morphological damage. The reversal effect may be derived from the anti-estrogenic properties of the plant quassinoids.
authors: School of Pharmaceutical Sciences, University of Science Malaysia, 11700 Penang, Malaysia. kitlamc@gmail.com
authors: Mahfoudh
authors: M
authors: Abdulghani
authors: Abas Hj
authors: AH
authors: Hussin
authors: Siti Amrah
authors: SA
authors: Sulaiman
authors: Kit Lam
authors: KL
authors: Chan
mesh_terms: D000568:Amenorrhea / Q000139:chemically induced / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D035701:Eurycoma / Q000737:chemistry*; D005260:Female; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000188:drug therapy*; D036702:Quassins / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000633:toxicity*; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D036702:Quassins; D013739:Testosterone