title: Complete genome sequence of a novel type of human parechovirus strain reveals natural recombination events.
abstract: Human parechoviruses (HPeVs) are a species in the Parechovirus genus of the Picornaviridae family. We report a complete genome sequence of a novel HPeV strain, CH-ZJ1, that was found in an infant with gastroenteritis in Zhenjiang City, China. The complete genome consists of 7,298 nucleotides (nt), excluding the 3' poly(A) tail; the open reading frame is mapped between nucleotide positions 654 and 7211 and encodes a 2,185-amino acid (aa) polyprotein. The phylogenetic tree obtained for the complete genome of this HPeV strain and the other HpeV strains available in GenBank indicated that CH-ZJ1 is intervenient between HpeV type 4 (HpeV4) and HpeV5. Phylogenetic analysis based on the 3D and VP1 genes reveals two incongruent trees. Recombination detection indicated that CH-ZJ1 might be a recombinant which was produced by more than one genomic recombination event that occurred among HPeV1, HPeV4, and HPeV3 strains.
authors: The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.
authors: Guangming
authors: G
authors: Sun
authors: Yong
authors: Y
authors: Wang
authors: Gang
authors: G
authors: Tao
authors: Quan
authors: Q
authors: Shen
authors: Weiping
authors: W
authors: Cao
authors: Xianlu
authors: X
authors: Chang
authors: Wen
authors: W
authors: Zhang
authors: Chen
authors: C
authors: Shao
authors: Miaoli
authors: M
authors: Yi
authors: Shihe
authors: S
authors: Shao
authors: Yan
authors: Y
authors: Yang
mesh_terms: D002681:China; D005759:Gastroenteritis / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D030061:Parechovirus / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral