title: Non-high-density lipoprotein cholesterol is associated more closely with albuminuria in Chinese type 2 diabetic patients with normal renal function, compared with traditional lipid parameters.
abstract: BACKGROUND
  Urinary albumin excretion rate (UAER) is a remarkable index reflecting the progression of kidney disease in diabetic subjects. The link between UAER and lipid metabolism is still unclear. The correlation of Apolipoprotein B (ApoB) to albuminuria has been investigated. The National Cholesterol Education Program-Adult Treatment Panel III recommends that clinicians consider non-high-density lipoprotein cholesterol (non-HDL-c) as a surrogate marker for ApoB.
  
  
  OBJECTIVE
  We sought to evaluate the relationship of UAER with lipid profile, especially with non-HDL-c in type 2 diabetic patients without renal dysfunction.
  
  
  METHODS
  A total of 507 type 2 diabetic patients with normal renal function participated in this study. Demographic and anthropometric data were collected; 24-hour urine samples were collected for UAER measurement. Blood samples were collected for lipid parameters and HbA1c measurement.
  
  
  RESULTS
  The patients with albuminuria had greater levels of non-HDL-c and ApoB. The frequencies of albuminuria among the four quartiles of lipid parameters, ie, triglycerides, total cholesterol, non-HDL-c, and ApoB, demonstrated significantly linearly increasing (P for trend <.01). After adjustment, UAER was significantly correlated with total cholesterol, triglycerides, ApoB, and non-HDL-c but not with low-density lipoprotein cholesterol (LDL-c) or lipoprotein(a) [Lp(a)]. Stepwise regression analysis showed that age (β = .255, P = .000), systolic blood pressure (β = .261, P = .000), non-HDL-c (β = .164, P = .000), and duration of diabetes (β = .105, P = .024) were independently correlated with UAER in diabetic patients without renal dysfunction.
  
  
  CONCLUSIONS
  Compared with the lipid parameters of total cholesterol, triglycerides, HDL-c, LDL-c, ApoB, Apolipoprotein A-I (ApoA-I), and Lp(a), non-HDL-c was more closely associated with albuminuria in Chinese type 2 diabetic patients without impaired renal function.
authors: Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, No. 600, Yishan Road, Shanghai, PR China.
authors: Jiemin
authors: J
authors: Pan
authors: Fei
authors: F
authors: Gao
authors: Yuqian
authors: Y
authors: Bao
authors: Lei
authors: L
authors: Zhang
authors: Yinfang
authors: Y
authors: Tu
authors: Weiping
authors: W
authors: Jia
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000150:complications / Q000175:diagnosis*; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood*; D044466:Asian People; D002681:China; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D002784:Cholesterol; D006442:Glycated Hemoglobin; D017270:Lipoprotein(a); D014280:Triglycerides; C517652:hemoglobin A1c protein, human