title: Regenerative endodontics: barriers and strategies for clinical translation.
abstract: Regenerative endodontics has encountered substantial challenges toward clinical translation. The adoption by the American Dental Association of evoked pulp bleeding in immature permanent teeth is an important step for regenerative endodontics. However, there is no regenerative therapy for most endodontic diseases. Simple recapitulation of cell therapy and tissue engineering strategies that are under development for other organ systems has not led to clinical translation in regeneration endodontics. Recent work using novel biomaterial scaffolds and growth factors that orchestrate the homing of host endogenous cells represents a departure from traditional cell transplantation approaches and may accelerate clinical translation.
authors: Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032, USA. jmao@columbia.edu
authors: Jeremy J
authors: JJ
authors: Mao
authors: Sahng G
authors: SG
authors: Kim
authors: Jian
authors: J
authors: Zhou
authors: Ling
authors: L
authors: Ye
authors: Shoko
authors: S
authors: Cho
authors: Takahiro
authors: T
authors: Suzuki
authors: Susan Y
authors: SY
authors: Fu
authors: Rujing
authors: R
authors: Yang
authors: Xuedong
authors: X
authors: Zhou
mesh_terms: D056624:Apexification / Q000379:methods; D000075202:Contraindications; D003782:Dental Pulp / Q000503:physiopathology*; D004708:Endodontics / Q000379:methods* / Q000639:trends; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000191:economics; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry