title: Cys-X-Cys ligand 9 might be an immunological factor in the pathogenesis of oral submucous fibrosis and its concomitant oral lichenoid lesion.
abstract: OBJECTIVE
  Oral submucous fibrosis (OSF) is a chronic oral precancerous disease primarily caused by betel quid chewing. Some OSF patients are concomitant with oral lichenoid lesion (OLL), a white-streak lesion with a higher risk for cancerization, in OSF mucosa. Immunological reaction has been considered as one of their common pathogenic mechanisms. Cys-X-Cys ligand 9 (CXCL9) is an important factor to recruit effector neutrophils and lymphocytes in immunological reactions. However, the expression levels of CXCL9 in OSF and OLL remain unclear.
  
  
  METHODS
  We investigated the expression levels of CXCL9 in 10 normal buccal mucosa (NBM) samples and 56 OSF concomitant with OLL patients, and evaluated the possible mechanism of CXCL9 on their pathogenesis.
  
  
  RESULTS
  Our results showed NBM demonstrated negative CXCL9 expression. OSF stained positive CXCL9 mainly in the cytoplasm of inflammatory cells and endothelial cells throughout the superficial layer of connective tissue, while its concomitant OLL showed much stronger CXCL9 in all mononuclear cells of subepithelial inflammatory infiltration (p = 0.0006). There was an upregulated trend of CXCL9 expression from NBM to OSF to OLL. However, no significant association between CXCL9 expression and clinicopathologic parameters of patients was found.
  
  
  CONCLUSIONS
  In conclusion, CXCL9 was found for the first time to contribute to the immunological pathogenesis for both OSF and its concomitant OLL, indicating a continuously enhanced intensity of immunoreactivity in their pathogenic process.
  
  
  CONCLUSIONS
  CXCL9 might be a useful tool to monitor the phase and disease severity of OSF and OLL, and a potential target for further clinical therapy for both lesions.
authors: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, People's Republic of China. liningbeta@hotmail.com
authors: Ning
authors: N
authors: Li
authors: Qiong
authors: Q
authors: Hu
authors: Canhua
authors: C
authors: Jiang
authors: Feng
authors: F
authors: Guo
authors: Krishna
authors: K
authors: Munnee
authors: Xinchun
authors: X
authors: Jian
authors: Yanjia
authors: Y
authors: Hu
authors: Zhangui
authors: Z
authors: Tang
mesh_terms: D000328:Adult; D015153:Blotting, Western; D016022:Case-Control Studies; D054370:Chemokine CXCL9 / Q000276:immunology* / Q000378:metabolism*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology* / Q000378:metabolism; D009914:Oral Submucous Fibrosis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D054370:Chemokine CXCL9