title: Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.
abstract: The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.
authors: I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, Russia.
authors: V Kh
authors: VKh
authors: Khavinson
authors: N S
authors: NS
authors: Linkova
authors: I M
authors: IM
authors: Kvetnoy
authors: T V
authors: TV
authors: Kvetnaia
authors: V O
authors: VO
authors: Polyakova
authors: H-W
authors: HW
authors: Korf
mesh_terms: D000818:Animals; D047068:Arylalkylamine N-Acetyltransferase / Q000096:biosynthesis*; D002478:Cells, Cultured; D017362:Cyclic AMP Response Element-Binding Protein / Q000096:biosynthesis*; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D009638:Norepinephrine / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D004151:Dipeptides; D009842:Oligopeptides; D047068:Arylalkylamine N-Acetyltransferase; C415909:lysylglutamic acid; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine; D009638:Norepinephrine