title: Kikuchi-Fujimoto disease mimicking tuberculous lymphadenitis.
abstract: A 28-year-old woman was referred to our hospital for treatment of tuberculous lymphadenitis, after presenting with fever, left cervical lymphadenopathy, and a positive interferon-gamma release assay (QuantiFERON®-TB Gold In-Tube; QFT) result. Surprisingly, biopsy specimens of the cervical lymph nodes showed necrotic lesions with prominent nuclear debris and a proliferation of histiocytes, consistent with Kikuchi-Fujimoto disease (KFD). A diagnosis was made of KFD complicated by latent tuberculosis infection (LTBI), and all symptoms had resolved completely two months post-diagnosis. KFD may be misdiagnosed as tuberculous lymphadenitis, and antibiotics unnecessarily prescribed. Careful attention should therefore be paid when diagnosing cervical lymphadenopathy.
authors: Department of Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
authors: Yu
authors: Y
authors: Kurahara
authors: Kazunobu
authors: K
authors: Tachibana
authors: Kenji
authors: K
authors: Tezuka
authors: Shigeki
authors: S
authors: Shimizu
authors: Masanori
authors: M
authors: Kitaichi
authors: Seiji
authors: S
authors: Hayashi
authors: Katsuhiro
authors: K
authors: Suzuki
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D055985:Latent Tuberculosis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D009333:Neck; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
chemical_list: D007371:Interferon-gamma