title: LupusQoL-FR is valid to assess quality of life in patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To cross-culturally adapt the LupusQoL into French, to test its measurement properties and to further investigate its domain structure.
  
  
  METHODS
  The cultural adaptation process according to guidelines and pre-testing resulted in the LupusQoL-FR. SLE patients completed the LupusQoL-FR at baseline, 15 days, 3 months and 6 months. Validity was studied through content and construct validity (factorial and Rasch analysis for structural validity, Spearman's correlation and Mann-Whitney tests for external validity). Cronbach's α and intra-class correlation coefficients were computed for reliability. The standardized response mean was computed to evaluate responsiveness.
  
  
  RESULTS
  In all, 182 patients, age 39.6 (10.6) years, mostly outpatients [mean SELENA-SLEDAI 2.6 (3.5)] were recruited. Factor analysis with eight imposed factors was very close to the original LupusQoL. A screeplot with parallel analysis showed that LupusQoL domains could be aggregated in two physical and mental scales. Both eight- and two-factor structures showed a good Rasch fit, internal consistency (Cronbach's α: 0.85-0.95), and test-retest reliability (intra-class correlation coefficient 0.79-0.95). External convergent (correlation with SF-36, r=0.59-0.78) and divergent validity (according to SELENA-SLEDAI) were also satisfactory.
  
  
  CONCLUSIONS
  The LupusQoL-FR is valid to assess quality of life in SLE patients. A two-factor structure of physical and mental aggregated scales is a valid alternative to the original eight-domain structure.
authors: Department of Internal Medicine and Systemic Disease, Dijon University Hospital, 3 rue Faubourg Raines, 21000 Dijon Cedex, France. hervedevilliers@free.fr
authors: Hervé
authors: H
authors: Devilliers
authors: Zahir
authors: Z
authors: Amoura
authors: Jean-Francois
authors: JF
authors: Besancenot
authors: Bernard
authors: B
authors: Bonnotte
authors: Jean-Louis
authors: JL
authors: Pasquali
authors: Denis
authors: D
authors: Wahl
authors: Francois
authors: F
authors: Maurier
authors: Pierre
authors: P
authors: Kaminsky
authors: Jean-Loup
authors: JL
authors: Pennaforte
authors: Nadine
authors: N
authors: Magy-Bertrand
authors: Laurent
authors: L
authors: Arnaud
authors: Christine
authors: C
authors: Binquet
authors: Francis
authors: F
authors: Guillemin
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D057566:Self Report; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014177:Translations