title: A cross-species view on viruses.
abstract: We describe the creative ways that virologists are leveraging experimental cross-species infections to study the interactions between viruses and hosts. While viruses are usually well adapted to their hosts, cross-species approaches involve pairing viruses with species that they do not naturally infect. These cross-species infections pit viruses against animals, cell lines, or even single genes from foreign species. We highlight examples where cross-species infections have yielded insights into mechanisms of host innate immunity, viral countermeasures, and the evolutionary interplay between viruses and hosts.
authors: Section of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA. saras@austin.utexas.edu
authors: Sara L
authors: SL
authors: Sawyer
authors: Nels C
authors: NC
authors: Elde
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology / Q000821:virology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000235:genetics
chemical_list: D014764:Viral Proteins