title: Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: a resting-state fMRI study.
abstract: BACKGROUND
  Patients with treatment-resistant depression (TRD) and those with treatment-sensitive depression (TSD) responded to antidepressants differently. Previous studies have commonly shown that patients with TRD or TSD had abnormal neural activity in different brain regions. In the present study, we used a coherence-based ReHo (Cohe-ReHo) approach to test the hypothesis that patients with TRD or TSD had abnormal neural activity in different brain regions.
  
  
  METHODS
  Twenty-three patients with TRD, 22 with TSD, and 19 healthy subjects (HS) matched with gender, age, and education level participated in the study.
  
  
  RESULTS
  ANOVA analysis revealed widespread differences in Cohe-ReHo values among the three groups in different brain regions which included bilateral superior frontal gyrus, bilateral cerebellum, left inferior temporal gyrus, left occipital cortex, and both sides of fusiform gyrus. Compared to HS, lower Cohe-ReHo values were observed in TRD group in bilateral superior frontal gyrus and left cerebellum; in contrast, in TSD group, lower Cohe-ReHo values were mainly found in bilateral superior frontal gyrus. Compared to TSD group, TRD group had lower Cohe-ReHo in bilateral cerebellum and higher Cohe-ReHo in left fusiform gyrus. There was a negative correlation between Cohe-ReHo values of the left fusiform gyrus and illness duration in the pooled patients (r = 0.480, p = 0.001). The sensitivity and specificity of cerebellar Cohe-ReHo values differentiating TRD from TSD were 83% and 86%, respectively.
  
  
  CONCLUSIONS
  Compared to healthy controls, both TRD and TSD patients shared the majority of brain regions with abnormal neural activity. However, the lower Cohe-ReHo values in the cerebellum might be as a marker to differentiate TRD from TSD with high sensitivity and specificity.
authors: Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
authors: Wen-bin
authors: WB
authors: Guo
authors: Feng
authors: F
authors: Liu
authors: Jin-dong
authors: JD
authors: Chen
authors: Keming
authors: K
authors: Gao
authors: Zhi-min
authors: ZM
authors: Xue
authors: Xi-jia
authors: XJ
authors: Xu
authors: Ren-rong
authors: RR
authors: Wu
authors: Chang-lian
authors: CL
authors: Tan
authors: Xue-li
authors: XL
authors: Sun
authors: Zhe-ning
authors: ZN
authors: Liu
authors: Hua-fu
authors: HF
authors: Chen
authors: Jing-ping
authors: JP
authors: Zhao
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply* / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012146:Rest; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D010100:Oxygen