title: Northward movement of East Central South African genotype of Chikungunya virus causing an epidemic between 2006-2010 in India.
abstract: BACKGROUND
  Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) and to determine the route of virus transmission in different parts of India.
  
  
  METHODS
  Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree.
  
  
  RESULTS
  BLAST search revealed 99% homology of the northern Indian strains of the 2006-2010 outbreak with the Reunion Island isolates of 2006. Northern Indian strains of this study clustered with the East Central South African (ECSA) genotype.
  
  
  CONCLUSIONS
  Findings indicate that the currently circulating strain of chikungunya virus in northern India had its origin from the 2006 epidemic strain of South India that moved toward northern India via the western central India between 2006-2010 in a phased manner with dominance of the ECSA genotype and not the Asian genotype.
authors: National Centre for Disease Control, 22 Sham Nath Marg, Delhi, India. priyankasingh.ncdc@gmail.com
authors: Priyanka
authors: P
authors: Singh
authors: Veena
authors: V
authors: Mittal
authors: Moshahid A
authors: MA
authors: Rizvi
authors: Dipesh
authors: D
authors: Bhattacharya
authors: Mala
authors: M
authors: Chhabra
authors: Devendra S
authors: DS
authors: Rawat
authors: Rattan L
authors: RL
authors: Ichhpujani
authors: Lakhvir S
authors: LS
authors: Chauhan
authors: Arvind
authors: A
authors: Rai
mesh_terms: D000293:Adolescent; D000328:Adult; D018354:Alphavirus Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D002646:Chikungunya virus / Q000145:classification* / Q000235:genetics*; D016000:Cluster Analysis; D058872:Epidemics; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D019371:Topography, Medical; D055815:Young Adult
chemical_list: D012367:RNA, Viral