title: Peptides as therapeutics with enhanced bioactivity.
abstract: The development of techniques for efficient peptide production renewed interest in peptides as therapeutics. Numerous modifications for improving stability, transport and affinity profiles now exist. Several new adjuvant and carrier systems have also been developed, enhancing the immunogenicity of peptides thus allowing their development as vaccines. This review describes the established and experimental approaches for manufacturing peptide drugs and highlights the techniques currently used for improving their drug like properties.
authors: School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Queensland, Australia.
authors: D
authors: D
authors: Goodwin
authors: P
authors: P
authors: Simerska
authors: I
authors: I
authors: Toth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D022223:Vaccines, Subunit / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010455:Peptides; D022223:Vaccines, Subunit