title: Human antibody response to Aedes aegypti saliva in an urban population in Bolivia: a new biomarker of exposure to Dengue vector bites.
abstract: Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children and steadily waned with age. Specific IgG levels were significantly higher in persons living in sites with higher Ae. aegypti density, as measured by using entomologic parameters. Logistic regression showed a significant correlation between IgG to saliva and exposure level, independently of either age or sex. These results suggest that antibody responses to saliva could be used to monitor human exposure to Aedes bites.
authors: Institut de Recherche pour le Développement, Maladie Infectieuse et Vecteurs, Ecologie, Génétique, Evolution et Contrôle, Centre Institut de Recherche pour le Développement de Montpellier, Montpellier, France. souleymane.doucoure@ird.fr
authors: Souleymane
authors: S
authors: Doucoure
authors: François
authors: F
authors: Mouchet
authors: Amandine
authors: A
authors: Cournil
authors: Gilbert
authors: G
authors: Le Goff
authors: Sylvie
authors: S
authors: Cornelie
authors: Yelin
authors: Y
authors: Roca
authors: Mabel Guerra
authors: MG
authors: Giraldez
authors: Zaira Barja
authors: ZB
authors: Simon
authors: Roxanna
authors: R
authors: Loayza
authors: Dorothée
authors: D
authors: Misse
authors: Jorge Vargas
authors: JV
authors: Flores
authors: Annie
authors: A
authors: Walter
authors: Christophe
authors: C
authors: Rogier
authors: Jean Pierre
authors: JP
authors: Herve
authors: Franck
authors: F
authors: Remoue
mesh_terms: D000293:Adolescent; D000328:Adult; D000330:Aedes; D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D015415:Biomarkers / Q000097:blood*; D001733:Bites and Stings / Q000175:diagnosis*; D001838:Bolivia / Q000453:epidemiology; D016000:Cluster Analysis; D003715:Dengue / Q000453:epidemiology* / Q000635:transmission*; D003906:Developing Countries; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007303:Insect Vectors / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012463:Saliva / Q000276:immunology; D014505:Urban Population; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G