title: Methoxetamine: from drug of abuse to rapid-acting antidepressant.
abstract: Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that methoxetamine can produce rapid antidepressant effects in patients with resistant and non-resistant unipolar and bipolar depression.
authors: Department of Addiction, ASL CN2, Viale Coppino 46, 12051 Alba (CN), Italy. coppolamail@alice.it
authors: M
authors: M
authors: Coppola
authors: R
authors: R
authors: Mondola
mesh_terms: D000778:Anesthetics, Dissociative / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000188:drug therapy; D003512:Cyclohexanones / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D013287:Illicit Drugs / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D008954:Models, Biological; D011976:Receptors, Muscarinic / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D017480:Receptors, sigma / Q000187:drug effects
chemical_list: D000778:Anesthetics, Dissociative; D000928:Antidepressive Agents; D003512:Cyclohexanones; D003514:Cyclohexylamines; D013287:Illicit Drugs; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; D011957:Receptors, Opioid; D017480:Receptors, sigma; D007649:Ketamine; C569113:2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone