title: Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations.
abstract: BACKGROUND
  Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair; its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus contribute to cancer risk.
  
  
  RESULTS
  In a hospital-based case-control study of 1115 esophageal squamous cell carcinoma (ESCC) cases and 1117 cancer-free controls, we genotyped three potentially functional SNPs of ERCC5 (SNPs, rs2296147T>C, rs2094258C>T and rs873601G>A) and estimated crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for their associations with risk of ESCC using unconditional logistic regression models. We also calculated false-positive report probabilities (FPRPs) for significant findings. We found that compared with the TT genotype, ERCC5 rs2296147 C variant genotypes were associated with a significantly lower ESCC risk (CT: adjusted OR = 0.76, 95% CI = 0.63-0.93, CT/CC: adjusted OR = 0.80, 95% CI = 0.67-0.96); however, this risk was not observed for the other two SNPs (rs2094258C>T and rs873601 G>A), nor in further stratification and haplotype analysis.
  
  
  CONCLUSIONS
  These findings suggested that ERCC5 polymorphisms may contribute to risk of ESCC in Eastern Chinese populations, but the effect was weak and needs further validation by larger population-based case-control studies.
authors: Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Mei-Ling
authors: ML
authors: Zhu
authors: Ting-Yan
authors: TY
authors: Shi
authors: Hai-Chuan
authors: HC
authors: Hu
authors: Jing
authors: J
authors: He
authors: Mengyun
authors: M
authors: Wang
authors: Li
authors: L
authors: Jin
authors: Ya-Jun
authors: YJ
authors: Yang
authors: Jiu-Cun
authors: JC
authors: Wang
authors: Meng-Hong
authors: MH
authors: Sun
authors: Huan
authors: H
authors: Chen
authors: Kuai-Le
authors: KL
authors: Zhao
authors: Zhen
authors: Z
authors: Zhang
authors: Hai-Quan
authors: HQ
authors: Chen
authors: Jia-Qing
authors: JQ
authors: Xiang
authors: Qing-Yi
authors: QY
authors: Wei
mesh_terms: D000368:Aged; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D004268:DNA-Binding Proteins; D004720:Endonucleases; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5