title: Prevalence of hyperhomocysteinaemia and its major determinants in rural Chinese hypertensive patients aged 45-75 years.
abstract: We aimed to investigate the prevalence of hyperhomocysteinaemia (total plasma homocysteine (tHcy) ≥ 10 μmol/l) and its major determinants in rural Chinese hypertensive patients. A cross-sectional investigation was carried out in Lianyungang of Jiangsu province, China. This analysis included 13 946 hypertensive adults. The prevalence of hyperhomocysteinaemia was 51.6 % (42.7 % in women and 65.6 % in men). The OR of hyperhomocysteinaemia were 1.52 (95 % CI 1.39, 1.67) and 2.32 (95 % CI 2.07, 2.61) for participants aged 55-65 and 65-75 v. 45-55 years; 1.27 (95 % CI 1.18, 1.37) for participants with a BMI ≥ 25 v. < 25 kg/m²; 1.14 (95 % CI 1.06, 1.23) for participants with v. without antihypertensive treatment; 1.09 (95 % CI 1.00, 1.18) for residents inland v. coastal; 0.89 (95 % CI 0.82, 0.97) and 0.83 (95 % CI 0.74, 0.92) for participants with moderate and high v. low physical activity levels; 1.54 (95 % CI 1.41, 1.68) and 2.47 (95 % CI 2.17, 2.81) for participants with a glomerular filtration rate 60-90 and < 60 v. ≥ 90 ml/min per 1.73 m²; and 1.20 (95 % CI 1.07, 1.35) and 3.81 (95 % CI 3.33, 4.36) for participants with CT and TT v. CC genotype at methylenetetrahydrofolate reductase 677C>T polymorphism, respectively. Furthermore, higher tHcy concentrations were observed in smokers of both sexes (men: geometric mean 12.1 (interquartile range (IQR) 9.2-14.5) v. 11.9 (IQR 9.-14.) μmol/l, P= 0.005; women: geometric mean 10·3 (IQR 8.3-13.0) v. 9.6 (IQR 7.8-11.6) μmol/l, P= 0.010), and only in males with hypertension grade 3 (v. grade 1 or controlled blood pressure) (geometric mean 12.1 (IQR 9.2-14.4) v. 11.7 (IQR 9.2-14.0), P= 0.016) and in male non-drinkers (yes v. no) (geometric mean 12.3 (IQR 9.4-14.8) v. 11.7 (IQR 9.1-13.9), P= 0.014). In conclusion, there was a high prevalence of hyperhomocysteinaemia in Chinese hypertensive adults, particularly in the inlanders, who may benefit greatly from tHcy-lowering strategies, such as folic acid supplementation and lifestyle change.
authors: Department of Geriatric Cardiology, PLA General Hospital, Beijing, People's Republic of China.
authors: Yu
authors: Y
authors: Wang
authors: Xiaoying
authors: X
authors: Li
authors: Xianhui
authors: X
authors: Qin
authors: Yefeng
authors: Y
authors: Cai
authors: Mingli
authors: M
authors: He
authors: Liming
authors: L
authors: Sun
authors: Jianping
authors: J
authors: Li
authors: Yan
authors: Y
authors: Zhang
authors: Genfu
authors: G
authors: Tang
authors: Binyan
authors: B
authors: Wang
authors: Ningling
authors: N
authors: Sun
authors: Xin
authors: X
authors: Xu
authors: Lisheng
authors: L
authors: Liu
authors: Xiping
authors: X
authors: Xu
authors: Yong
authors: Y
authors: Huo
mesh_terms: D000368:Aged; D000375:Aging; D000428:Alcohol Drinking / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000235:genetics; D006973:Hypertension / Q000188:drug therapy / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009043:Motor Activity; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D051437:Renal Insufficiency / Q000209:etiology; D012307:Risk Factors; D012423:Rural Health / Q000208:ethnology; D012720:Severity of Illness Index; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000959:Antihypertensive Agents; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)