title: Giant benign lymphangioendothelioma.
abstract: Benign lymphangioendothelioma is a rare locally infiltrative vascular neoplasm, presenting as a slow-growing, asymptomatic, reddish-violaceous plaque. Histopathologically, it is characterized by irregular and thin-walled vascular spaces, lined by a single and discontinuous layer of flat endothelial cells, dissecting dermal collagen bundles. We present the case of a 75-year-old man with a giant benign lymphangioendothelioma, to our knowledge, the largest example described in the literature. The immunohistochemical expression of Wilms tumor 1 gene is useful in vascular lesions to differentiate malformations from proliferative endothelial lesions. In our case, the positivity for WT1 supports the neoplastic nature of this lesion.
authors: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors: Juan M
authors: JM
authors: Revelles
authors: Jose L
authors: JL
authors: Díaz
authors: Jorge
authors: J
authors: Angulo
authors: Carlos
authors: C
authors: Santonja
authors: Heinz
authors: H
authors: Kutzner
authors: Luis
authors: L
authors: Requena
mesh_terms: D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D008202:Lymphangioma / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*