title: The pre-emptive analgesic effect of a cyclooxygenase-2 inhibitor in a rat model of acute postoperative pain.
abstract: We examined the pre-emptive analgesic effect of a cyclooxygenase (COX)-2 inhibitor in a rat surgical pain model and characterised the changes in cutaneous COX-2 around a surgical site. Thermal hyperalgesia and mechanical allodynia were tested in the rats for three days after incision and skin tissues were collected for analysis of COX-2. There was decreased expression of cutaneous COX-2 one day after surgical incision. Pre-incision injection of the COX-2 inhibitor significantly inhibited expression of COX-2 and also reduced thermal hyperalgesia (but not mechanical allodynia) compared with the post-incision COX-2-inhibitor injection group, one day after incision.
authors: Department of Anaesthesia, Kaohsiung Armed Forces Hospital, Kaohsiung, Taiwan.
authors: J J
authors: JJ
authors: Chen
authors: K C
authors: KC
authors: Hung
authors: K
authors: K
authors: Lu
authors: S W
authors: SW
authors: Yu
authors: C C
authors: CC
authors: Chang
authors: C C
authors: CC
authors: Liu
authors: J
authors: J
authors: Spielberger
authors: P Y
authors: PY
authors: Ku
authors: P H
authors: PH
authors: Tan
mesh_terms: D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D015153:Blotting, Western; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D006358:Hot Temperature; D006930:Hyperalgesia / Q000517:prevention & control; D008297:Male; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D010149:Postoperative Pain / Q000517:prevention & control*; D010812:Physical Stimulation; D011720:Pyrazoles / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; C119130:4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide; D000096926:Benzenesulfonamides