title: Gene network profiling before and after transplantation in alcoholic cirrhosis liver transplant recipients.
abstract: The main objective of this study was to define a gene network profile network in liver transplant recipients with alcoholic cirrhosis before and after liver transplantation. Genes were selected from data obtained in a previous study of liver transplant recipients with alcoholic cirrhosis. Selected up-regulated genes were further validated by quantitative real-time polymerase chain reaction in different groups of liver transplant recipients with alcoholic cirrhosis (n=5). Selected genes up-regulated before transplantation were: TNFRSF9 (tumor necrosis factor [TNF] receptor superfamily, member 9); IL2RB (interleukin-2 receptor beta); BCL2L2 (BCL2-like 2); NOX5 (NADPH) oxidase, EF-hand calcium binding domain 5); PEX5 (peroxisomal biogenesis factor 5); PPARG (peroxisome proliferator-activated receptor gamma); NIBP (IKK2 binding protein); NKIRAS2 (NFKappaBeta inhibitor interacting Ras-like 2); IL4 (interleukin-4); IL-4R (interleukin 4 receptor); ADH1A (alcohol dehydrogenase 1A, class 1); ALDH1L1 (aldehyde dehydrogenase 1 family, member L1); MPO (myeloperoxidase); NPPA (natriuretic peptide precursor A); BCL2A1 (BCL2-related protein A1); GADD45A (growth arrest and DNA-damage-inducible alpha); TEGT (Bax inhibitor 1); PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide); IFNGR2 (interferon gamma receptor 2); JAK2 (Janus Kinase 2); FAS (Fas, TNF receptor superfamily, member 6); TANK (TRAF family member-associated NFKB activator); TTRAP (TRAF and TNF receptor-associated protein); and ANXA5 (annexin A5).
authors: General and Digestive Surgery Service, Experimental Surgery Research Unit, Virgen de las Nieves University Hospital, Granada, Spain.
authors: K
authors: K
authors: Muffak-Granero
authors: C
authors: C
authors: Olmedo
authors: F
authors: F
authors: Garcia-Alcalde
authors: A
authors: A
authors: Comino
authors: T
authors: T
authors: Villegas
authors: J M
authors: JM
authors: Villar
authors: D
authors: D
authors: Garrote
authors: A
authors: A
authors: Blanco
authors: P
authors: P
authors: Bueno
authors: J-A
authors: JA
authors: Ferron
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000235:genetics* / Q000601:surgery*; D016031:Liver Transplantation; D020411:Oligonucleotide Array Sequence Analysis; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome