title: Basal GLP-1 levels in morbidly obese patients following biliopancreatic diversion surgery.
abstract: BACKGROUND
  Previous studies addressing the changes of glucagon-like peptide-1 (GLP-1) concentrations in morbidly obese patients after bariatric surgery have demonstrated conflicting results. The aim of the present study was to investigate the changes in serum GLP-1 levels 9 months after biliopancreatic diversion in morbidly obese patients without diabetes mellitus.
  
  
  METHODS
  A sample of 40 morbidly obese patients without diabetes mellitus was enrolled. Biochemical and anthropometrical evaluations were conducted at basal and 9 months after surgery.
  
  
  RESULTS
  The mean patient age was 46.6 ± 13.1 years, and the mean preoperative body mass index (BMI) was 47.1 ± 18.1. A significant decrease in BMI, weight, waist circumference, fat mass, glucose, LDL cholesterol, total cholesterol, and triglyceride levels was observed after 9 months. Serum basal GLP-1 levels did not change after surgery (0.65 ± 0.18 ng/ml vs. 0.66 ± 0.17 ng/ml; n.s.). Postsurgical correlation analysis showed a negative association between basal GLP-1 and HDL cholesterol (r = -0.57; p < 0.01).
  
  
  CONCLUSIONS
  Fasting GLP-1 concentrations did not change after massive weight loss with biliopancreatic diversion in morbidly obese patients without diabetes mellitus.
authors: Institute of Endocrinology and Nutrition, Medicine School, Unit of Investigation, Surgical Department and Endocrinology Department, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors: Daniel
authors: D
authors: de Luis
authors: D
authors: D
authors: Pacheco
authors: Rosa
authors: R
authors: Conde
authors: David
authors: D
authors: Primo
authors: Rocio
authors: R
authors: Aller
authors: Olatz
authors: O
authors: Izaola
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D002318:Cardiovascular Diseases; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus; D005260:Female; D005500:Follow-Up Studies; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D014280:Triglycerides; D052216:Glucagon-Like Peptide 1