title: Platelet count alterations associated with escitalopram, venlafaxine and bupropion in depressive patients.
abstract: The objective of the present study was to evaluate changes in platelet counts on three different kinds of antidepressant. All subjects (n = 131) in their drug-naïve state had been diagnosed with depression. Escitalopram (n = 42), venlafaxine (n = 50) and bupropion (n = 39) were prescribed, and platelet count was measured before and after 1 month of treatment and compared. Decrease in platelet count on escitalopram was significant, while the others were not. These findings suggest that escitalopram may be associated with decreased platelet count, and bupropion is less likely to exert an influence on platelet count.
authors: Department of Psychiatry, Yeouido St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors: Hoo Rim
authors: HR
authors: Song
authors: Young-Eun
authors: YE
authors: Jung
authors: Hee-Ryung
authors: HR
authors: Wang
authors: Young Sup
authors: YS
authors: Woo
authors: Tae-Youn
authors: TY
authors: Jun
authors: Won-Myong
authors: WM
authors: Bahk
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D001792:Blood Platelets / Q000187:drug effects; D016642:Bupropion / Q000009:adverse effects*; D015283:Citalopram / Q000009:adverse effects*; D003511:Cyclohexanols / Q000009:adverse effects*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D016642:Bupropion; D015283:Citalopram; D000069470:Venlafaxine Hydrochloride