title: Molecular buckets: cyclodextrins for oral cancer therapy.
abstract: The oral route is preferred by patients for drug administration due to its convenience, resulting in improved compliance. Unfortunately, for a number of drugs (e.g., anticancer drugs), this route of administration remains a challenge. Oral chemotherapy may be an attractive option and especially appropriate for chronic treatment of cancer. However, this route of administration is particularly complicated for the administration of anticancer drugs ascribed to Class IV of the Biopharmaceutical Classification System. This group of compounds is characterized by low aqueous solubility and low intestinal permeability. This review focuses on the use of cyclodextrins alone or in combination with bioadhesive nanoparticles for oral delivery of drugs. The state-of-the-art technology and challenges in this area is also discussed.
authors: Department of Pharmacy & Pharmaceutical Technology, University of Navarra, 31080 Pamplona, Spain.
authors: Patricia
authors: P
authors: Calleja
authors: Judit
authors: J
authors: Huarte
authors: Maite
authors: M
authors: Agüeros
authors: Luisa
authors: L
authors: Ruiz-Gatón
authors: Socorro
authors: S
authors: Espuelas
authors: Juan M
authors: JM
authors: Irache
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003505:Cyclodextrins / Q000008:administration & dosage*; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000008:administration & dosage; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D011108:Polymers