title: Pleiotropy of microRNA-192 in the kidney.
abstract: Diverse aetiologies result in significant deviation from homoeostasis in the kidney, leading to CKD (chronic kidney disease). CKD progresses to end-stage renal disease principally as a result of renal fibrosis, although the molecular mechanisms underlying this fibrotic process are still poorly understood. miRNAs (microRNAs) are a recently discovered family of endogenous short single-stranded RNAs that regulate global gene expression at the post-transcriptional level. The recent findings from our laboratory and others discussed in the present review outline pleiotropic roles for miR-192 in renal homoeostasis and in the fibrotic kidney. We describe miR-192-driven anti-and pro-fibrotic effects via the repression of ZEB1 and ZEB2 (zinc finger E-box-binding homeobox proteins 1 and 2), resulting in changes in extracellular matrix deposition and cell differentiation.
authors: Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, UK. jenkinsrh2@cf.ac.uk
authors: Robert H
authors: RH
authors: Jenkins
authors: John
authors: J
authors: Martin
authors: Aled O
authors: AO
authors: Phillips
authors: Timothy
authors: T
authors: Bowen
authors: Donald J
authors: DJ
authors: Fraser
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000235:genetics; D051536:Hepatocyte Nuclear Factors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D051536:Hepatocyte Nuclear Factors; D035683:MicroRNAs