title: Effects of the oral administration of mosapride citrate on capsule endoscopy completion rate.
abstract: OBJECTIVE
  In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate, a 5-hydroxytryptamine-4 agonist that increases gastrointestinal motility, on CE completion.
  
  
  METHODS
  In a retrospective study, we performed univariate and multivariate analyses for 232 CE procedures performed at our hospital. To identify factors that affect CE completion, the following data were systematically collected: gender, age, gastric transit time (GTT), nonsteroidal anti-inflammatory drug administration, previous abdominal surgery, hospitalization, use of a polyethylene glycol solution, use of mosapride citrate (10 mg), body mass index (BMI), and total recording time.
  
  
  RESULTS
  The univariate analysis showed that oral mosapride citrate, GTT, and BMI were associated with improved CE completion. Multivariate analyses showed that oral mosapride citrate (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.01 to 3.91) and GTT (OR, 2.34; 95% CI, 1.13 to 4.87) were significant factors for improving the CE completion. Oral mosapride citrate significantly shortened the GTT and small bowel transit time (SBTT).
  
  
  CONCLUSIONS
  Oral mosapride citrate reduced the GTT and SBTT during CE and improved the CE completion rate.
authors: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
authors: Yosuke
authors: Y
authors: Ida
authors: Naoki
authors: N
authors: Hosoe
authors: Hiroyuki
authors: H
authors: Imaeda
authors: Rieko
authors: R
authors: Bessho
authors: Riko
authors: R
authors: Ichikawa
authors: Makoto
authors: M
authors: Naganuma
authors: Takanori
authors: T
authors: Kanai
authors: Toshifumi
authors: T
authors: Hibi
authors: Haruhiko
authors: H
authors: Ogata