title: Finding a niche with personalized generics: opportunities from systems-based therapeutic delivery in hypertension.
abstract: A key principle in earlier eras of drug development was to deliver medicines with clinical benefits for populations. Individual patients frequently did not benefit, or experienced adverse drug reactions, and were at risk of exposure to a prolonged series of treatment trials before effective therapies were found, if available. A personalized medicines approach offers opportunities to select drugs likely to be effective or safer, based on knowledge, for example, of differences in disease-modulating receptors, in drug metabolism, or in drug transporters into cells and across tissue boundaries. This new genetic and phenotypic knowledge allows generics to be revisited and may also help to improve medicine adherence, by reducing predictable adverse effects from unwanted accumulation of a medicine or its metabolites. This review will consider effective population delivery of therapeutics to treat hypertension in order to illustrate the potential and current place of personalizing medicines to improve effective and safe use of therapeutics.
authors: Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, CV2 2DX, UK. d.r.singer@warwick.ac.uk
authors: Donald
authors: D
authors: Singer
mesh_terms: D016568:Drugs, Generic / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D055118:Medication Adherence; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D057285:Precision Medicine; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage
chemical_list: D016568:Drugs, Generic; D017673:Sodium Chloride, Dietary