title: Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes.
abstract: OBJECTIVE
  We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels.
  
  
  METHODS
  Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models.
  
  
  RESULTS
  Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for ≥1 year compared to the AA genotype (adjusted odds ratio [OR], 3.05; 95% confidence interval [CI], 1.12-8.25). Adding serum estradiol concentrations to the confounder-adjusted model resulted in a nonsignificant association (adjusted OR, 2.59; 95% CI, 0.91-7.18). Carriers of both CYP1B1 (rs1800440) G and CYP1B1 (rs1058636) G alleles had higher odds of experiencing hot flashes for ≥1 year compared to women homozygous for the major alleles (adjusted OR, 1.77; 95% CI, 1.06-2.96), even after adjustment for serum estradiol.
  
  
  CONCLUSIONS
  CYP1B1 is associated with menopausal hot flashes via pathways that may involve changes in serum estradiol concentration.
authors: Department of Comparative Biosciences, University of Illinois, Urbana, IL 61802, USA.
authors: Ayelet
authors: A
authors: Ziv-Gal
authors: Lisa
authors: L
authors: Gallicchio
authors: Susan R
authors: SR
authors: Miller
authors: Howard A
authors: HA
authors: Zacur
authors: Jodi A
authors: JA
authors: Flaws
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D003430:Cross-Sectional Studies; D065633:Cytochrome P-450 CYP1B1; D005260:Female; D019584:Hot Flashes / Q000235:genetics*; D006801:Humans; D008593:Menopause / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics*; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D018336:Receptors, Aryl Hydrocarbon; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1