title: Pathophysiological cytokine network in primary Sjögren's syndrome.
abstract: The continuing progress in discovering lymphocyte subsets and the lengthening list of cytokines involved, together with how they are affected in primary Sjögren's syndrome (pSS), has further fuelled the debate on pSS pathogenesis. In this review the "interferon signature" observed in the salivary glands and the role of T-cell derived cytokines (Th1/Th2 polarization, Th17 and regulatory T cells) will be discussed. A particular emphasis has been placed on the B-cell derived cytokines and especially on FLT3-Ligand, a cytokine associated with lymphoma in pSS, and B-cell activating factor (BAFF) that prevents apoptosis of autoreactive B cells. It has indeed become a challenge to understand how the interaction between several interconnected networks of cytokines impact so different cell population in the immunopathogenesis of pSS.
authors: Université Européenne de Bretagne, Université de Brest, Research Unit EA 2216 "Immunology and Pathology", 29609 Brest, France. pers@univ-brest.fr
authors: Jacques-Olivier
authors: JO
authors: Pers
authors: Ayan
authors: A
authors: Lahiri
authors: Gabriel J
authors: GJ
authors: Tobón
authors: Pierre
authors: P
authors: Youinou
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology; D053264:B-Cell Activating Factor / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D016764:Cell Polarity / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000276:immunology; D008024:Ligands; D008565:Membrane Proteins / Q000276:immunology; D012469:Salivary Glands / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D053264:B-Cell Activating Factor; D016207:Cytokines; D008024:Ligands; D008565:Membrane Proteins; C505719:TNFSF13B protein, human; C084881:flt3 ligand protein; D007372:Interferons