title: Mouse allergen, lung function, and atopy in Puerto Rican children.
abstract: OBJECTIVE
  To examine the relation between mouse allergen exposure and asthma in Puerto Rican children.
  
  
  METHODS
  Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV(1) and FEV(1)/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures.
  
  
  RESULTS
  Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV(1) in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6-132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI =  -0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5-0.9, P<0.01). In a multivariate analysis including all children at both study sites, each log-increment in mouse allergen was positively associated with FEV(1) (+28.3 ml, 95% CI = 1.4-55.2 ml, P = 0.04) and inversely associated with STR to ≥1 allergen (OR for each log-unit increment in Mus m 1 = 0.8, 95% CI = 0.6-0.9, P<0.01).
  
  
  CONCLUSIONS
  Mouse allergen is associated with a higher FEV(1) and lower odds of STR to ≥1 allergen in Puerto Rican children. This may be explained by the allergen itself or correlated microbial exposures.
authors: Division of Pediatric Pulmonology, Department of Pediatrics, University of Miami, Miami, Florida, United States of America.
authors: Erick
authors: E
authors: Forno
authors: Michelle M
authors: MM
authors: Cloutier
authors: Soma
authors: S
authors: Datta
authors: Kathryn
authors: K
authors: Paul
authors: Jody
authors: J
authors: Sylvia
authors: Deanna
authors: D
authors: Calvert
authors: Sherell
authors: S
authors: Thornton-Thompson
authors: Dorothy B
authors: DB
authors: Wakefield
authors: John
authors: J
authors: Brehm
authors: Robert G
authors: RG
authors: Hamilton
authors: María
authors: M
authors: Alvarez
authors: Angel
authors: A
authors: Colón-Semidey
authors: Edna
authors: E
authors: Acosta-Pérez
authors: Glorisa
authors: G
authors: Canino
authors: Juan C
authors: JC
authors: Celedón
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002947:Cities / Q000706:statistics & numerical data; D004391:Dust / Q000276:immunology; D006801:Humans; D008168:Lung / Q000276:immunology* / Q000502:physiology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D015999:Multivariate Analysis; D011647:Puerto Rico / Q000453:epidemiology
chemical_list: D000485:Allergens; D004391:Dust