title: [The role of oxidative processes in augmentation of atherogenity of low density lipoprotein particles].
abstract: We investigated action of natural dicarbonyl compounds which are formed in atherosclerosis and diabetes on properties of low density lipoproteins (LDL) such as surface charge, conformational changes of apoB100, susceptibility to oxidation. and aggregation rate. It was found that malonic dialdehyde (MDA) compared with glyoxal and methylglyoxal is more effective modificating agent of protein part of LDL particle. Nevertheless glyoxal and methylglyoxal-dependent modification of LDL can accelerate processes of further free radical peroxidation increasing atherogenity of LDL particles.
authors: E M
authors: EM
authors: Kumskova
authors: D V
authors: DV
authors: Aksenov
authors: G G
authors: GG
authors: Konovalova
authors: A K
authors: AK
authors: Tikhaze
authors: V Z
authors: VZ
authors: Lankin
mesh_terms: D053299:Apolipoprotein B-100 / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D050197:Atherosclerosis / Q000150:complications / Q000378:metabolism*; D001797:Blood Protein Electrophoresis / Q000379:methods; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D008315:Malondialdehyde / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011765:Pyruvaldehyde / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties
chemical_list: D053299:Apolipoprotein B-100; D005609:Free Radicals; D008077:Lipoproteins, LDL; D008315:Malondialdehyde; D011765:Pyruvaldehyde