title: Cd2+ complex of a triazole-based calix[4]arene conjugate as a selective fluorescent chemosensor for Cys.
abstract: An N,N-Dimethylamine ethylimino-appended triazole-linked calix[4]arene conjugate, L, has been synthesized and characterized, and its Cd(2+) complex has been isolated and characterized. The structure of [CdL] was established by computational calculation using B3LYP/LANL2DZ. Time-dependent density functional theory calculations were performed to demonstrate the electronic properties of [CdL]. This highly fluorescing [CdL] has been used to recognize Cys selectively among the 20 naturally occurring amino acids. [CdL] exhibits a minimum detection limit of 58 ppb for Cys, with reusability and reversibility being imparted to the system during sensing. Thus, the sensing of Cys was well demonstrated using various techniques, viz., fluorescence, absorption, visual color change, electrospray ionization MS, (1)H NMR, and live cell imaging experiments.
authors: Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
authors: Rakesh K
authors: RK
authors: Pathak
authors: Vijaya K
authors: VK
authors: Hinge
authors: Kandula
authors: K
authors: Mahesh
authors: Ankit
authors: A
authors: Rai
authors: Dulal
authors: D
authors: Panda
authors: Chebrolu P
authors: CP
authors: Rao
mesh_terms: D002104:Cadmium / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D010636:Phenols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D014230:Triazoles / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D007477:Ions; D010636:Phenols; D014230:Triazoles; C121325:calix(4)arene; D002104:Cadmium; D047250:Calixarenes; D003545:Cysteine