title: Complete response in a patient with granulosa cell tumor treated with a combination of leuprolide and tamoxifen.
abstract: BACKGROUND
  Adult granulosa cell tumors (GCTs) are frequently hormonally active. Thus, hormonal agents have been evaluated for the treatment of advanced-stage or recurrent disease.
  
  
  METHODS
  A 39-year-old patient presented with recurrent GCT. The patient received multiple treatment modalities, including surgery and 2 different chemotherapy regimens (cisplatin- and taxanebased). Abdominal computed tomography following these treatments showed local recurrence with multiple implants. The patient's inhibin B level increased to 187 pg/ml at this time. The patient was treated with leuprolide 11.25 mg every 3 months and tamoxifen 20 mg twice daily. The patient's inhibin B level began to decrease after 1 month and returned to normal after 4 months. The patient has been maintained on this treatment for 2 years and has tolerated the drugs well.
  
  
  CONCLUSIONS
  The combination of leuprolide and tamoxifen had limited side effects in the presented patient and might be a viable treatment option for women with advanced-stage or recurrent adult ovarian GCTs.
authors: Department of Medical Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey. drkeskin76@hotmail.com
authors: Serkan
authors: S
authors: Keskin
authors: Ergin
authors: E
authors: Bengisu
authors: Sitki
authors: S
authors: Tuzlali
authors: Adnan
authors: A
authors: Aydiner
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013629:Tamoxifen / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D013629:Tamoxifen; D016729:Leuprolide