title: One step back before moving forward: regulation of transcription elongation by arrest and backtracking.
abstract: RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene regulation is yet to be addressed. Structural studies into the backtracked complex, new reactivation mechanisms and genome-wide approaches are shedding some light on this interesting aspect of gene transcription. In this review, we briefly summarise these new findings, comment about some results recently obtained in our laboratory, and propose a new model for the influence of the chromatin context on RNA polymerase II backtracking.
authors: Departamento de Genética, Universidad de Sevilla, Seville, Spain.
authors: Fernando
authors: F
authors: Gómez-Herreros
authors: Lola
authors: L
authors: de Miguel-Jiménez
authors: Gonzalo
authors: G
authors: Millán-Zambrano
authors: Xenia
authors: X
authors: Peñate
authors: Lidia
authors: L
authors: Delgado-Ramos
authors: Mari Cruz
authors: MC
authors: Muñoz-Centeno
authors: Sebastián
authors: S
authors: Chávez
mesh_terms: D002843:Chromatin / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D012319:RNA Polymerase II / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D012319:RNA Polymerase II