title: Serum chemerin levels are associated with the presence and extent of coronary artery disease.
abstract: OBJECTIVE
  The aim of the study was to examine whether serum chemerin levels are associated with the presence and the extent of coronary artery disease (CAD).
  
  
  METHODS
  A total of 132 patients with CAD and 56 patients without CAD who underwent coronary angiography for the evaluation of CAD were enrolled in this study. Serum levels of chemerin were measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum chemerin levels were significantly elevated in CAD patients compared with those without CAD. Multivariate logistic regression analysis showed that serum chemerin levels were significantly associated with the presence of CAD. In CAD patients, chemerin was positively correlated with BMI (r=0.274, P=0.001) and triglycerides (r=0.190, P=0.029), and yet correlated with low-density lipoprotein-cholesterol (r=0.228, P=0.008); the association of chemerin with triglycerides and low-density lipoprotein-cholesterol remained significant after adjusting for BMI (P<0.05 and P<0.01). At multiple stepwise regression analysis, serum chemerin levels were an independent predictor of the stenosis score (β=0.193, P=0.034).
  
  
  CONCLUSIONS
  Our data suggest that increased chemerin levels are associated with the presence of CAD and that serum chemerin levels may reflect the extent of coronary atherosclerosis.
authors: Department of Cardiology, Beijing Armed Police Corps Hospital, China. lxt_med@163.com
authors: Li
authors: L
authors: Xiaotao
authors: Zhang
authors: Z
authors: Xiaoxia
authors: Xia
authors: X
authors: Yue
authors: Wei
authors: W
authors: Liye
mesh_terms: D054392:Adipokines / Q000097:blood; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D023921:Coronary Stenosis / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018925:Chemokines; D008078:Cholesterol, LDL; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D014280:Triglycerides