title: Evaluation of whether intracameral dexamethasone predisposes to glaucoma after pediatric cataract surgery.
abstract: OBJECTIVE
  To evaluate the effect of intracameral dexamethasone during pediatric cataract surgery on the incidence of postoperative glaucoma.
  
  
  METHODS
  Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital, London, United Kingdom.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  This case-note review comprised all infants who had cataract surgery with intraocular lenses between January 1, 2007, and December 31, 2008, and were given preservative-free intracameral dexamethasone intraoperatively. The definition of glaucoma was an intraocular pressure (IOP) of 21 mm Hg or greater on more than 2 occasions or moderate or firm digital IOP with 1 of the following: myopic shift, increased cup-to-disc ratio, increased horizontal corneal diameter, or corneal edema.
  
  
  RESULTS
  Eighteen patients (24 eyes) were included. The median age at surgery was 3 months (mean 4 months ± 3 (SD); range 1 to 11 months). The median follow-up was 38 months (mean 34 ± 10 months; range 20 to 48 months). In 4 eyes, transient postoperative antihypertensive medication was used; however, no eye developed glaucoma during the follow-up period. Fifteen eyes had a second procedure to clear the visual axis due to posterior visual axis opacification a mean of 6.4 ± 3.5 months postoperatively (median 4.8 months; range 3.5 to 14.5 months); however, no eye developed anterior membranes.
  
  
  CONCLUSIONS
  Intracameral preservative-free dexamethasone in infantile cataract surgery did not seem to cause an increased risk for glaucoma and appeared to protect against anterior membrane formation.
authors: Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital, London, United Kingdom.
authors: Asimina
authors: A
authors: Mataftsi
authors: Ahmad
authors: A
authors: Dabbagh
authors: Will
authors: W
authors: Moore
authors: Ken K
authors: KK
authors: Nischal
mesh_terms: D000867:Anterior Chamber / Q000187:drug effects*; D002386:Cataract / Q000151:congenital; D002387:Cataract Extraction; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000139:chemically induced* / Q000175:diagnosis; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects; D019654:Lens Implantation, Intraocular; D008297:Male; D009798:Ocular Hypertension / Q000139:chemically induced / Q000175:diagnosis; D011183:Postoperative Complications; D011310:Preservatives, Pharmaceutical; D012189:Retrospective Studies; D012307:Risk Factors; D014065:Tonometry, Ocular; D014821:Vitrectomy
chemical_list: D005938:Glucocorticoids; D011310:Preservatives, Pharmaceutical; D003907:Dexamethasone