title: Sinularones A-I, new cyclopentenone and butenolide derivatives from a marine soft coral Sinularia sp. and their antifouling activity.
abstract: Nine new compounds, namely sinularones A-I (1-9), characterized as cyclopentenone and butenolide-type analogues, were isolated from a soft coral Sinularia sp., together with a known butenolide (10). Their structures were elucidated by means of spectroscopic (IR, MS, 1D and 2D NMR, CD) analysis. The absolute configurations were determined on the basis of CD and specific rotation data in association with the computed electronic circular dichroism (ECD) by time dependent density functional theory (TD DFT) at 6-31+G(d,p)//DFT B3LYP/6-31+G(d,p) level. Compounds 1-2 and 7-10 showed potent antifouling activities against the barnacle Balanus amphitrite.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors: Haiyan
authors: H
authors: Shi
authors: China National Center for Biotechnology Development, Beijing 100036, China.
authors: Shanjiang
authors: S
authors: Yu
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors: Dong
authors: D
authors: Liu
authors: National Museum of Natural History Naturalis, 2300 RA, Leiden 9515, The Netherlands.
authors: Leen
authors: L
authors: Van Ofwegen
authors: Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Duesseldorf 40225, Germany.
authors: Peter
authors: P
authors: Proksch
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors: Wenhan
authors: 0000-0002-4978-4083
authors: W
authors: Lin
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002942:Circular Dichroism / Q000379:methods; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D001468:Thoracica / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D003517:Cyclopentanes; C004511:butenolide; D015107:4-Butyrolactone; C013905:cyclopentenone