title: Personalized medicine: the impact on chemistry.
abstract: An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift, that of network pharmacology. We examine the intersection of personalized medicine and network pharmacology to identify strategies for the development of personalized therapies that are fully informed by network pharmacology concepts. This provides a framework for discussion of the impact personalized medicine will have on chemistry in terms of drug discovery, formulation and delivery, the adaptations and changes in ideology required and the contribution chemistry is already making. New ways of conceptualizing chemistry's relationship with medicine will lead to new approaches to drug discovery and hold promise of delivering safer and more effective therapies.
authors: Department of Chemistry, University of Warwick, UK.
authors: John
authors: J
authors: Watkins
authors: Andrew
authors: A
authors: Marsh
authors: Paul C
authors: PC
authors: Taylor
authors: Donald R J
authors: DR
authors: Singer
mesh_terms: D002621:Chemistry; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D055808:Drug Discovery; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006899:Mixed Function Oxygenases / Q000235:genetics; D010600:Pharmacology; D057285:Precision Medicine; D064417:Vitamin K Epoxide Reductases
chemical_list: D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6; D064417:Vitamin K Epoxide Reductases