title: Hailey-Hailey disease treated with methotrexate.
abstract: BACKGROUND
  Hailey-Hailey disease (HHD) is a chronic, recurrent blistering disorder characterized clinically by erosions occurring primarily in intertriginous regions and histologically by suprabasal acantholysis.
  
  
  METHODS
  We report a long standing case of HHD initially unresponsive to cyclosporin, multiple topical and systemic steroids. Good response was achieved with methotrexate 7,5 mg weekly for 16 week, intramuscularly, and topical steroids as needed.
  
  
  CONCLUSIONS
  In conclusion, we suggest that methotrexate could be considered a therapeutic option for the treatment of HHD and in particular as a maintaining therapy to control the disease flares.
authors: Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence, Florence, Italy.
authors: Antonietta
authors: A
authors: D'Errico
authors: Diletta
authors: D
authors: Bonciani
authors: Veronica
authors: V
authors: Bonciolini
authors: Alice
authors: A
authors: Verdelli
authors: Emiliano
authors: E
authors: Antiga
authors: Paolo
authors: P
authors: Fabbri
authors: Marzia
authors: M
authors: Caproni