title: Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis.
abstract: Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 microg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.
authors: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw
authors: Tian-Shung
authors: TS
authors: Wu
authors: Chung-Ren
authors: CR
authors: Sun
authors: Kuo-Hsiung
authors: KH
authors: Lee
mesh_terms: D000470:Alkaloids / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031369:Cryptocarya / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D006801:Humans; D007212:Indolizines / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D007212:Indolizines; D010618:Phenanthrolines; C521640:phenanthroindolizidine