title: Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease.
abstract: The relationship between serum anti-heat shock protein (Hsp)27 antibody and high sensitive C-reactive protein (hs-CRP) levels and indices of cardiac function were investigated in patients undergoing coronary artery bypass grafting (CABG) or heart valve replacement. The changes in anti-Hsp27 antibody titers and hs-CRP levels were compared among patients undergoing off-pump and on-pump CABG or valvular heart replacement. Fifty-three patients underwent off-pump, on-pump CABG, and heart valvular replacement in each group. Serum anti-Hsp27 titers and hs-CRP values were measured 24 h before and after the operation and at discharge. Echocardiography was performed before surgery and before discharge. The results were compared with values from 83 healthy controls. hs-CRP levels increased and anti-Hsp27 antibody decreased following surgery (P < 0.001 and P < 0.05, respectively), although these changes were independent of operative procedure (P = 0.361 and P = 0.120, respectively). Anti-Hsp27 antibody levels were higher at the time of discharge (P = 0.016). Only in coronary patients were anti-Hsp27 antibody levels negatively associated with E/E' (r = -0.268, P = 0.022), a marker of pulmonary capillary wedge pressure. In conclusions, anti-Hsp27 antibody levels are associated with indices of cardiac function in coronary patients. Cardiopulmonary bypass had no significant effect on the induction of changes in anti-Hsp27 levels. Moreover, anti-Hsp27 antibody levels fell in all groups postoperatively; this may be due to the formation of immune complexes of antigen-antibody, and antibody levels were higher at the time of discharge.
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors: Amir Ali
authors: AA
authors: Rahsepar
authors: Asadollah
authors: A
authors: Mirzaee
authors: Fatemeh
authors: F
authors: Moodi
authors: Mohsen
authors: M
authors: Moohebati
authors: Shima
authors: S
authors: Tavallaie
authors: Fatemeh
authors: F
authors: Khorashadizadeh
authors: Ali
authors: A
authors: Eshraghi
authors: Maryam-Sadat
authors: MS
authors: Alavi
authors: Laya
authors: L
authors: Zarrabi
authors: Mostafa
authors: M
authors: Sajjadian
authors: Maral
authors: M
authors: Amini
authors: Roshanak
authors: R
authors: Khojasteh
authors: Roghayeh
authors: R
authors: Paydar
authors: Somayeh
authors: S
authors: Mousavi
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon A
authors: GA
authors: Ferns
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D001021:Aortic Valve / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D047549:Coronary Artery Bypass, Off-Pump; D004452:Echocardiography; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D000906:Antibodies; D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D002097:C-Reactive Protein