title: Nucleotide excision repair: new tricks with old bricks.
abstract: Nucleotide excision repair (NER) is a major DNA repair pathway that ensures that the genome remains functionally intact and is faithfully transmitted to progeny. However, defects in NER lead, in addition to cancer and aging, to developmental abnormalities whose clinical heterogeneity and varying severity cannot be fully explained by the DNA repair deficiencies. Recent work has revealed that proteins in NER play distinct roles, including some that go well beyond DNA repair. NER factors are components of protein complexes known to be involved in nucleosome remodeling, histone ubiquitination, and transcriptional activation of genes involved in nuclear receptor signaling, stem cell reprogramming, and postnatal mammalian growth. Together, these findings add new pieces to the puzzle for understanding NER and the relevance of NER defects in development and disease.
authors: Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.
authors: Irene
authors: I
authors: Kamileri
authors: Ismene
authors: I
authors: Karakasilioti
authors: George A
authors: GA
authors: Garinis
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D058685:Genetic Pleiotropy; D016678:Genome; D006801:Humans; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004247:DNA