title: Clinical neuroprotective drugs for treatment and prevention of stroke.
abstract: Stroke is an enormous public health problem with an imperative need for more effective therapies. In therapies for ischemic stroke, tissue plasminogen activators, antiplatelet agents and anticoagulants are used mainly for their antithrombotic effects. However, free radical scavengers, minocycline and growth factors have shown neuroprotective effects in the treatment of stroke, while antihypertensive drugs, lipid-lowering drugs and hypoglycemic drugs have shown beneficial effects for the prevention of stroke. In the present review, we evaluate the treatment and prevention of stroke in light of clinical studies and discuss new anti-stroke effects other than the main effects of drugs, focusing on optimal pharmacotherapy.
authors: Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.|Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Kiyoshi
authors: K
authors: Kikuchi
authors: Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.|Uchikado Neuro-Spine Clinic, 1-2-3 Naka, Hakata-ku, Fukuoka 812-0893, Japan.
authors: Hisaaki
authors: H
authors: Uchikado
authors: Department of Neurosurgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Motohiro
authors: M
authors: Morioka
authors: Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Yoshinaka
authors: Y
authors: Murai
authors: Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors: Eiichiro
authors: E
authors: Tanaka
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020521:Stroke / Q000517:prevention & control*
chemical_list: D000959:Antihypertensive Agents; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D018696:Neuroprotective Agents