title: Approach to polysubstituted 4-pyridones from N-aryl acetoacetamides via a N to C 1,3-acyl migration mediated by sodium persulfate.
abstract: Mediated by sodium persulfate (Na(2)S(2)O(8)), a series of polysubstituted 4-pyridones were synthesized via self-condensation of N-aryl acetoacetamides, during which a novel N to C 1,3-acyl migration should be involved. The structure of 4-pyridone was unequivocally confirmed by X-ray diffraction analysis. However, the self-condensation of N-benzyl acetoacetamides under the same condition gave polysubstituted 2-pyridones instead of 4-pyridones.
authors: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang 453007, China. zhangzhiguo3030@yahoo.com.cn
authors: Zhiguo
authors: Z
authors: Zhang
authors: Shiliang
authors: S
authors: Fang
authors: Qingfeng
authors: Q
authors: Liu
authors: Guisheng
authors: G
authors: Zhang
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D017670:Sodium Compounds / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*
chemical_list: D000081:Acetamides; D011728:Pyridones; D017670:Sodium Compounds; D013431:Sulfates; C024625:sodium persulfate