title: Recent progress on fucosyltransferase inhibitors.
abstract: Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the treatment of such disorders. This review highlights recent developments regarding carbohydrate mimics as inhibitors of FucTs. The most recent and relevant synthetic strategies are described.
authors: Departamento de Quimica Orgánica, Instituto de Sintesis Quimica y Catalisis Homogenea (ISQCH), Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain. pmerino@unizar.es
authors: Pedro
authors: P
authors: Merino
authors: Tomás
authors: T
authors: Tejero
authors: Ignacio
authors: I
authors: Delso
authors: Ramon
authors: R
authors: Hurtado-Guerrero
authors: Asier
authors: A
authors: Gómez-SanJuan
authors: David
authors: D
authors: Sádaba
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology*; D032701:Biomimetics / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005647:Fucosyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006001:Glycoconjugates / Q000737:chemistry* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002241:Carbohydrates; D004791:Enzyme Inhibitors; D006001:Glycoconjugates; D006027:Glycosides; D010880:Piperidines; D011759:Pyrrolidines; D005647:Fucosyltransferases