title: [Complete elimination of cytomegalovirus without antiviral therapy after systemic transplantation of mesenchymal bone marrow stromal cells in a patient with ulcerative colitis].
abstract: Cytomegalovirus infection (CMV) has become in the last 15-20 years one of the most important problems of scientific research and clinical high attention. This is due to new information discovered about its leading role in the origin, development, and the outcome of a large group of serious diseases. Cytomegalovirus (CMV) is one of the most common causative agents of opportunistic infections (OI) in patients with IBD, which are mandatory feature of the state of immunodeficiency. Numerous studies in vivo and in vitro studies have demonstrated that mesenchymal stromal cells (MSCs) suppress immune reactions to allogeneic stimulation, but not the invasion of infection, as well as themselves possess antiviral and antimicrobial activity, as demonstrated in this clinical case.
authors: O V
authors: OV
authors: Kniazev
authors: I N
authors: IN
authors: Ruchkina
authors: A I
authors: AI
authors: Parfenov
authors: A G
authors: AG
authors: Konopliannikov
authors: V E
authors: VE
authors: Sagynbaeva
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood / Q000628:therapy* / Q000821:virology; D003106:Colon / Q000473:pathology / Q000821:virology; D003113:Colonoscopy; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000097:blood / Q000628:therapy* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M