title: [Apoptosis of the hypothalamus neurosecretory cells in stress and ageing: the role of immune modulators].
abstract: There is assumption about active role of immune modulators in cell death process. The involvement of interferon-alpha and cycloferon in apoptosis regulation of hypothalamic neurons of mice during stress and aging was studied. We determined the expression of apoptosis markers (Bcl-2, Mcl-1, Bax) in comparison with apoptosis level. We have found that immune modulators suppress activity of nonapeptidergic neurons. Thus, interferon-alpha treatment reduces synthesis of Bcl-2; cycloferon treatment inhibits expression of Bax and Bcl-2. So the role of immune modulators in neuron apoptosis depends on the stage of ontogenesis and type of immune modulator. Cycloferon is able to reduce the level of age-dependent apoptosis of neurons in aging, but under stress condition both interferon-alpha and cycloferon act as protectors of cell death.
authors: E D
authors: ED
authors: Bazhanova
mesh_terms: D000166:Acridines / Q000008:administration & dosage*; D000375:Aging / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D018496:Hyperoxia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007103:Immobilization; D007155:Immunologic Factors / Q000008:administration & dosage; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D051379:Mice; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000276:immunology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology
chemical_list: D000166:Acridines; D007155:Immunologic Factors; D016898:Interferon-alpha; C579094:Mcl1 protein, mouse; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2; C026430:10-carboxymethyl-9-acridanone