title: Renal failure: implications of chronic kidney disease in the management of the diabetic foot.
abstract: Foot complications are common in patients with diabetes, however, chronic kidney disease has emerged as an independent risk factor for development of foot lesions in the diabetic population. Apart from peripheral arterial disease, infection, and neuropathy, which are classic factors contributing to development of foot lesions, skin disorders specific to renal failure, impaired wound healing from uremia, and psychosocial issues offer further compounded risk. Consequently, there are high ulceration and amputation rates that are associated with increased morbidity and mortality. In recent studies, foot-care programs with a multidisciplinary approach within dialysis units have demonstrated improved outcomes.
authors: Division of Renal Diseases and Hypertension, Medical Faculty Associates, The George Washington University School of Medicine, Washington, DC 20037, USA.
authors: Shari
authors: S
authors: Lewis
authors: Dominic
authors: D
authors: Raj
authors: Nicolas J
authors: NJ
authors: Guzman
mesh_terms: D000671:Amputation, Surgical; D003131:Combined Modality Therapy; D015897:Comorbidity; D017719:Diabetic Foot / Q000453:epidemiology / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000453:epidemiology*; D006801:Humans; D023821:Limb Salvage; D051437:Renal Insufficiency / Q000453:epidemiology*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D014945:Wound Healing