title: The diagnostic value of 18F-FDG-PET/CT in hematopoietic radiation toxicity: a Tibet minipig model.
abstract: This study was undertaken to assess the diagnostic value of 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomography ([(18)F]-FDG-PET/CT) in the detection of radiation toxicity in normal bone marrow using Tibet minipigs as a model. Eighteen Tibet minipigs were caged in aseptic rooms and randomly divided into six groups. Five groups (n = 3/group) were irradiated with single doses of 2, 5, 8, 11 and 14 Gy of total body irradiation (TBI) using an 8-MV X-ray linear accelerator. These pigs were evaluated with [(18)F]-FDG-PET/CT, and their marrow nucleated cells were counted. The data were initially collected at 6, 24 and 72 h after treatment and were then collected on Days 5-60 post-TBI at 5-day intervals. At 24 and 72 h post-TBI, marrow standardized uptake value (SUV) data showed a dose-dependent decrease in the radiation dose range from 2-8 Gy. Upon long-term observation, SUV and marrow nucleated cell number in the 11-Gy and 14-Gy groups showed a continuous and marked reduction throughout the entire time course, while Kaplan-Meier curves of survival showed low survival. In contrast, the SUVs in the 2-, 5- and 8-Gy groups showed early transient increases followed by a decline from approximately 72 h through Days 5-15 and then normalized or maintained low levels through the endpoint; marrow nucleated cell number and survival curves showed approximately the same trend and higher survival, respectively. Our findings suggest that [(18)F]-FDG-PET/CT may be helpful in quickly assessing the absorbed doses and predicting the prognosis in patients.
authors: Department of Hematology, Zhujiang Hospital, Southern Medical University, 253# Industry Road, Guangzhou, Guangdong, China.
authors: Chi
authors: C
authors: Chen
authors: Li-Meng
authors: LM
authors: Yan
authors: Kun-Yuan
authors: KY
authors: Guo
authors: Yu-Jue
authors: YJ
authors: Wang
authors: Fei
authors: F
authors: Zou
authors: Wei-Wang
authors: WW
authors: Gu
authors: Hua
authors: H
authors: Tang
authors: Yan-Ling
authors: YL
authors: Li
authors: Shao-Jie
authors: SJ
authors: Wu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D019788:Fluorodeoxyglucose F18; D006413:Hematopoietic System / Q000187:drug effects*; D008297:Male; D010315:Particle Accelerators; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014965:X-Rays
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18