title: Effect of omega-3 polyunsaturated fatty acids and body condition on serum concentrations of adipokines in healthy dogs.
abstract: OBJECTIVE
  To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids or body condition and serum concentrations of adiponectin, leptin, insulin, glucose, or triglyceride in healthy dogs.
  
  
  METHODS
  62 healthy adult client-owned dogs.
  
  
  METHODS
  Body condition score and percentage of body fat were determined. Blood samples were collected after food was withheld for 12 hours. Serum was harvested for total lipid determination, fatty acid analysis, and measurement of serum concentrations of adiponectin, leptin, insulin, glucose, and triglyceride. Associations between the outcome variables (adiponectin, leptin, insulin, glucose, and triglyceride concentrations) and each of several variables (age, sex, percentage of body fat, and concentrations of total lipid, α-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) were determined.
  
  
  RESULTS
  Serum concentrations of docosapentaenoic acid were significantly positively associated with concentrations of adiponectin and leptin and negatively associated with concentrations of triglyceride. Serum concentrations of α-linolenic acid were significantly positively associated with concentrations of triglyceride. No significant associations were detected between serum concentrations of eicosapentaenoic acid or docosahexaenoic acid and any of the outcome variables. Percentage of body fat was significantly positively associated with concentrations of leptin, insulin, and triglyceride but was not significantly associated with adiponectin concentration. Age was positively associated with concentrations of leptin, insulin, and triglyceride and negatively associated with concentrations of adiponectin. Sex did not significantly affect serum concentrations for any of the outcome variables.
  
  
  CONCLUSIONS
  Docosapentaenoic acid may increase serum concentrations of adiponectin and leptin and decrease serum triglyceride concentration in healthy dogs.
authors: Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA. mazaki-tovi@dcpah.msu.edu
authors: Michal
authors: M
authors: Mazaki-Tovi
authors: Sarah K
authors: SK
authors: Abood
authors: Patricia A
authors: PA
authors: Schenck
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D003430:Cross-Sectional Studies; D004283:Dog Diseases / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D015525:Fatty Acids, Omega-3 / Q000097:blood* / Q000737:chemistry; D005260:Female; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D036361:Peptide Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones; D014280:Triglycerides