title: Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation.
abstract: Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging. Cytotoxicity studies employing metabolic and trypan blue assays manifested their excellent biocompatibility. The production of reactive oxygen species in iron oxide nanoparticle loaded MCF-7 cells was explained to originate from both, the release of iron ions and their catalytically active surfaces. Both initiate the Fenton and Haber-Weiss reaction. Additional oxidative stress caused by X-ray irradiation of MCF-7 cells was attributed to the increase of catalytically active iron oxide nanoparticle surfaces.
authors: Department of Chemistry and Pharmacy, Physical Chemistry I and ICMM, Friedrich-Alexander University of Erlangen-Nuremberg, Egerlandstr. 3, D-91058 Erlangen, Germany.
authors: Stefanie
authors: S
authors: Klein
authors: Anja
authors: A
authors: Sommer
authors: Luitpold V R
authors: LV
authors: Distel
authors: Winfried
authors: W
authors: Neuhuber
authors: Carola
authors: C
authors: Kryschi
mesh_terms: D045744:Cell Line, Tumor; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D058185:Magnetite Nanoparticles; D009369:Neoplasms / Q000378:metabolism*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014965:X-Rays
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; C000499:ferric oxide