title: A prognostic score based on clinical factors and biomarkers for advanced non-small cell lung cancer.
abstract: OBJECTIVE
  The objective of the present study is to determine the prognostic value of clinical variables and biomarkers in patients with advanced stages of NSCLC and establish a prognostic classification of these patients.
  
  
  METHODS
  For 135 patients with advanced NSCLC we determined their clinical variables and their levels of CEA, CA 125, CYFRA 21-1, albumin, LDH, erythrosedimentation and leukocytes.
  
  
  RESULTS
  Multivariate analysis identified PS (ECOG) >1, metastases, no anti-neoplastic treatment, CA 125 >35 U/mL, CYFRA 21-1 >3.3 ng/mL and leukocytes >10'000/µL, as independent prognostic factors for survival. Patients were classified into 3 groups according to the number of adverse prognostic factors (APF). One point was assigned for each APF, except for chemotherapy treatment. Patients with 0-1 APF represented our reference group: patients with 2-3 APF had HR=2.7 (95% CI: 1.5-4.6), while patients with 4-5 APF had HR=8.8 (95% CI: 4.6-16.8). This "score" maintained the differences between risk groups both in patients who received antineoplastic treatment and in those who did not.
  
  
  CONCLUSIONS
  The application of a score that includes clinical data and biomarkers may improve the prognostic classification of NSCLC patients.
authors: Laboratory Medicine Service, Althaia, Xarxa Assistencial Universitària de Manresa, Manresa, Barcelona, Spain. jtrape@althaia.cat
authors: Jaume
authors: J
authors: Trapé
authors: Jesus
authors: J
authors: Montesinos
authors: Sílvia
authors: S
authors: Catot
authors: Josep
authors: J
authors: Buxó
authors: Josefina
authors: J
authors: Franquesa
authors: Maria
authors: M
authors: Sala
authors: Montserrat
authors: M
authors: Domenech
authors: Francesc
authors: F
authors: Sant
authors: Josep M
authors: JM
authors: Badal
authors: Anna
authors: A
authors: Arnau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor