title: Modulation of immune signalling by inhibitors of apoptosis.
abstract: The inhibitor of apoptosis (IAP) genes are critical regulators of multiple pathways that control cell death, proliferation, and differentiation. Several members of the IAP family regulate innate and adaptive immunity through modulation of signal transduction pathways, cytokine production, and cell survival. The regulation of immunity by the IAPs is primarily mediated through the ubiquitin ligase function of cellular IAP (cIAP)1, cIAP2, and X-linked IAP (XIAP), the targets of which impact nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signalling pathways. In addition, neuronal apoptosis inhibitory protein (NAIP), cIAP1, and cIAP2 modulate innate immune responses through control of the inflammasome complex. This review examines the role of mammalian IAPs in regulating immunity and describes the implications of a new class of pan-IAP antagonists for the treatment of immune disorders.
authors: Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.
authors: Shawn T
authors: ST
authors: Beug
authors: Herman H
authors: HH
authors: Cheung
authors: Eric C
authors: EC
authors: LaCasse
authors: Robert G
authors: RG
authors: Korneluk
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology*; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D016328:NF-kappa B