title: Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives.
abstract: In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, and the antioxidant properties. We have used the 4-hydroxycoumarin moiety (compound 1) as the molecular template for the synthesis of compounds 2-7. These derivates have shown moderate trypanocidal activity. However they have been proved to be good antioxidants. In particular compound 7 is the most active antioxidant and it is, therefore, a potential candidate for a successful employment in conditions characterized by free radicals overproduction.
authors: Departamento de Química Inorgánica y Analitica, Laboratorio de radicales libres y antioxidantes, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Casilla 233, Santiago 1, Chile.
authors: Fernanda
authors: F
authors: Pérez-Cruz
authors: Silvia
authors: S
authors: Serra
authors: Giovanna
authors: G
authors: Delogu
authors: Michel
authors: M
authors: Lapier
authors: Juan Diego
authors: JD
authors: Maya
authors: Claudio
authors: C
authors: Olea-Azar
authors: Lourdes
authors: L
authors: Santana
authors: Eugenio
authors: E
authors: Uriarte
mesh_terms: D015110:4-Hydroxycoumarins / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D014355:Chagas Disease / Q000188:drug therapy; D006801:Humans; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D015110:4-Hydroxycoumarins; D000975:Antioxidants; D014344:Trypanocidal Agents