title: Study of drug release and tablet characteristics of silicone adhesive matrix tablets.
abstract: Matrix tablets of a model drug acetaminophen (APAP) were prepared using a highly compressible low glass transition temperature (T(g)) polymer silicone pressure sensitive adhesive (PSA) at various binary mixtures of silicone PSA/APAP ratios. Matrix tablets of a rigid high T(g) matrix forming polymer ethyl cellulose (EC) were the reference for comparison. Drug release study was carried out using USP Apparatus 1 (basket), and the relationship between the release kinetic parameters of APAP and polymer/APAP ratio was determined to estimate the excipient percolation threshold. The critical points attributed to both silicone PSA and EC tablet percolation thresholds were found to be between 2.5% and 5% w/w. For silicone PSA tablets, satisfactory mechanical properties were obtained above the polymer percolation threshold; no cracking or chipping of the tablet was observed above this threshold. Rigid EC APAP tablets showed low tensile strength and high friability. These results suggest that silicone PSA could eliminate issues related to drug compressibility in the formulation of directly compressed oral controlled release tablets of poorly compressible drug powder such as APAP. No routinely used excipients such as binders, granulating agents, glidants, or lubricants were required for making an acceptable tablet matrix of APAP using silicone PSA.
authors: Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, OH 45267-0004, USA. toliagv@mail.uc.edu
authors: Gaurav
authors: G
authors: Tolia
authors: S Kevin
authors: SK
authors: Li
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage* / Q000737:chemistry; D000269:Adhesives / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D011208:Powders; D012828:Silicones / Q000737:chemistry*; D013607:Tablets; D013718:Tensile Strength; D044366:Transition Temperature
chemical_list: D000269:Adhesives; D005079:Excipients; D011208:Powders; D012828:Silicones; D013607:Tablets; D000082:Acetaminophen; C013517:ethyl cellulose; D002482:Cellulose