title: Effect of esophagoplasty on structural reorganization of colon transplant.
abstract: We studied ultrastructural reorganization of the colon transplant in delayed period after esophagoplasty. It was found that during functioning of the artificial esophagus, a complex of adaptive and pathologic processes occurs in the mucosa. Focal sclerosis of the mucosa and slight epithelial degeneration with hyperplasia and hypersecretion of goblet cells were found in biopsy specimens with stenosis of the anastomosis. In case of colonopathy of the transplant, more pronounced epithelial degeneration and proliferation accompanied by abundant polymorphocellular stromal infiltration were seen. Deformation of the transplant was characterized by progressive atrophic and sclerotic reorganization of the mucosa. Goblet cells with ultrastructural signs of hypersecretion predominated in the population of epithelial cells of the colon transplant; oligomucus and poorly differentiated cell and colonocytes with signs of alteration and degenerative changes in cytoplasmic organelles were also found.
authors: Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
authors: L M
authors: LM
authors: Nepomnyashchikh
authors: G A
authors: GA
authors: Lapii
authors: Yu V
authors: YV
authors: Chikinev
authors: I E
authors: IE
authors: Sudovykh
authors: I A
authors: IA
authors: Tokmakov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003106:Colon / Q000637:transplantation* / Q000648:ultrastructure*; D003251:Constriction, Pathologic; D004940:Esophageal Stenosis / Q000473:pathology* / Q000601:surgery; D004944:Esophagoplasty / Q000009:adverse effects; D004947:Esophagus / Q000601:surgery* / Q000648:ultrastructure; D005260:Female; D020397:Goblet Cells / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000648:ultrastructure; D011183:Postoperative Complications; D019737:Transplants; D055815:Young Adult