title: DNA methylation in cognition comes of age.
abstract: A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.
authors: Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
authors: Susan C
authors: SC
authors: Su
authors: Li-Huei
authors: LH
authors: Tsai
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D003072:Cognition Disorders / Q000201:enzymology* / Q000503:physiopathology; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D019175:DNA Methylation / Q000502:physiology*; D000090205:DNA Methyltransferase 3A; D006624:Hippocampus / Q000201:enzymology* / Q000503:physiopathology; D008569:Memory Disorders / Q000201:enzymology* / Q000503:physiopathology; D051379:Mice
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A