title: Neutrophil extracellular trap in human diseases.
abstract: NETosis is a unique death pathway that differs from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. During this process, neutrophil extracellular traps (NETs) are created. NETs are extracellular structures composed of chromatin and variety of proteins from cells granules that bind and kill microorganisms. Recently, novel functions of NET have been proposed. It seems that neutrophil traps play an essential role during autoimmunity. They can induce and exacerbate diseases based on immune system malfunction.
authors: Department of Laboratory Diagnostic and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland. magdaarazna@gmail.com
authors: Magdalena
authors: M
authors: Arazna
authors: Michal P
authors: MP
authors: Pruchniak
authors: Katarzyna
authors: K
authors: Zycinska
authors: Urszula
authors: U
authors: Demkow
mesh_terms: D015551:Autoimmunity; D001424:Bacterial Infections / Q000276:immunology; D016923:Cell Death; D002843:Chromatin; D003594:Cytoplasmic Granules / Q000378:metabolism; D006801:Humans; D009181:Mycoses / Q000276:immunology; D019255:NADPH Oxidases / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology; D018375:Neutrophil Activation; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D011528:Protozoan Infections / Q000276:immunology; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D002843:Chromatin; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases