title: SGEF is overexpressed in prostate cancer and contributes to prostate             cancer progression.
abstract: The purpose of this study was to investigate the potential roles of the             SH3-containing guanine nucleotide exchange factor (SGEF) in human prostate cancer.             Experimental data showed that SGEF was overexpressed in human prostate cancer             cells and specimens. The reduction of SGEF expression through an SGEF-targeting             siRNA in androgen-independent C4-2 and C4-2B cells suppressed both anchorage-dependent             and anchorage-independent growth. In addition, the androgen receptor (AR) antagonist             bicalutamide further strengthened this inhibitory effect due to the suppression             of the elevated AR transactivation after knockdown of SGEF. Collectively, our             results provide the first demonstration that SGEF is a novel promoter of human             prostate cancer progression and development.
authors: Laboratory of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, PR China.
authors: Hongtao
authors: H
authors: Wang
authors: Ruiqin
authors: R
authors: Wu
authors: Lan
authors: L
authors: Yu
authors: Feima
authors: F
authors: Wu
authors: Shanhu
authors: S
authors: Li
authors: Yali
authors: Y
authors: Zhao
authors: Hailiang
authors: H
authors: Li
authors: Guolan
authors: G
authors: Luo
authors: Jian
authors: J
authors: Wang
authors: Jianguang
authors: J
authors: Zhou
mesh_terms: D059002:Androgen Receptor Antagonists / Q000494:pharmacology; D000813:Anilides / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D009570:Nitriles / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D034741:RNA, Small Interfering; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014105:Tosyl Compounds / Q000494:pharmacology; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured
chemical_list: C473930:ARHGEF26 protein, human; D059002:Androgen Receptor Antagonists; D000813:Anilides; D020662:Guanine Nucleotide Exchange Factors; D009570:Nitriles; D034741:RNA, Small Interfering; D011944:Receptors, Androgen; D014105:Tosyl Compounds; C053541:bicalutamide; D051057:Proto-Oncogene Proteins c-akt