title: Self-reported uptake of recommendations after dissemination of medication incident alerts.
abstract: BACKGROUND
  In the Netherlands, a Central Medication Incidents Registration (CMR) system is operational. To prevent recurrence of reported medication incidents the CMR sends medication incident alerts with recommendations. It is up to the healthcare workers whether or not to implement the recommendations in clinical practice, which may lead to variations in degrees of uptake of the recommendations.
  
  
  OBJECTIVE
  The aim of this study was to explore the degree of self-reported uptake of the recommendations and to identify potential determinants associated with successful uptake.
  
  
  METHODS
  This is a cross-sectional study conducted within a convenience sample of 33 Dutch hospital pharmacies. The study was carried out from April 2009 to September 2010.
  
  
  METHODS
  Three alerts were selected for the study: administration of methotrexate in a dosage of once a day instead of once a week, administration of undiluted potassium-sodium-phosphate concentrate, and administration of glucose 50% instead of 5%. The primary outcome was the degree of self-reported uptake of the specific recommendations and the associations of the degree of uptake with several potential determinants.
  
  
  RESULTS
  Twenty-one hospitals (63.6%) had adopted all recommendations about methotrexate. A quarter of the hospitals (24.2%) had adopted all recommendations related to potassium-sodium-phosphate concentrate. For the alert about glucose 50%, none of the hospitals had implemented all the recommendations. No statistically significant associations between potential determinants and the degree of uptake were found.
  
  
  CONCLUSIONS
  This study is the first to investigate the degree of uptake of the recommendations of three different CMR alerts. The alerts varied in the degrees of self-reported uptake of the recommendations, with the methotrexate alert having the highest degree of uptake. No significant associations with potential determinants were found.
authors: IQ Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. k.c.cheung@knmp.nl
authors: Ka-Chun
authors: KC
authors: Cheung
authors: Michel
authors: M
authors: Wensing
authors: Marcel L
authors: ML
authors: Bouvy
authors: Peter A G M
authors: PA
authors: De Smet
authors: Patricia M L A
authors: PM
authors: van den Bemt
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D003430:Cross-Sectional Studies; D004338:Drug Combinations; D005947:Glucose / Q000008:administration & dosage; D019983:Guideline Adherence / Q000592:standards* / Q000706:statistics & numerical data; D006801:Humans; D033181:Information Dissemination; D008508:Medication Errors / Q000145:classification / Q000706:statistics & numerical data; D008727:Methotrexate / Q000008:administration & dosage; D009426:Netherlands; D010607:Pharmacy Service, Hospital / Q000592:standards* / Q000706:statistics & numerical data; D057566:Self Report
chemical_list: D004338:Drug Combinations; D005947:Glucose; D008727:Methotrexate