title: Effect of carbon coating on the physico-chemical properties and toxicity of copper and nickel nanoparticles.
abstract: The primary aim of these interdisciplinary studies is to investigate the effect of surface carbon coating on the physico-chemical properties and toxicity of carbon-coated and noncoated copper and nickel nanoparticles (C-Cu, Cu, C-Ni, Ni NPs) in A549 alveolar epithelial cells. Compared to Cu NPs, C-Cu NPs exhibit protection against surface oxidation, tenfold higher cellular uptake, and fourfold lower release of soluble Cu. The toxicity of C-Cu NPs and Cu NPs is associated with pronounced damage to mitochondrial function and plasma membrane integrity, respectively. Compared to Cu and C-Cu NPs, Ni and C-Ni NPs are less toxic. These studies demonstrate that correlations can be drawn between physico-chemical properties and resultant toxicity of NPs as a function of surface carbon coating.
authors: Division of Molecular Pharmaceutics and the Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina, at Chapel Hill, NC 27599, USA.
authors: Shalini
authors: S
authors: Minocha
authors: Russell J
authors: RJ
authors: Mumper
mesh_terms: D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D055598:Chemical Phenomena / Q000187:drug effects*; D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D019281:Dimerization; D004996:Ethidium / Q000378:metabolism; D005452:Fluoresceins / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism; D053768:Metal Nanoparticles / Q000633:toxicity* / Q000648:ultrastructure; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009532:Nickel / Q000378:metabolism / Q000633:toxicity*; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D012995:Solubility; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D005452:Fluoresceins; C085925:calcein AM; D002244:Carbon; D003300:Copper; D009532:Nickel; D004996:Ethidium