title: Influence of GIRK channel inhibition on relapse risk in Japanese alcohol-dependent inpatients.
abstract: We examined the influence of G-protein-activated inwardly rectifying K+ (GIRK) channel inhibition on relapse risk in Japanese alcohol-dependent inpatients. The participants included 11 patients who received GIRK inhibition treatment and 39 patients who did not receive GIRK inhibition treatment. The participants answered a questionnaire, including the Alcohol Relapse Risk Scale (ARRS) and a questionnaire about their experiences of stressful events 2 weeks after hospitalization (time 1) and completed follow-up questionnaires 45-60 days after the first rating (time 2). A significant interaction was found between group and time on positive expectancy for alcohol scores on the ARRS (F = 5.93, p = 0.02). The scores at time 2 were lower than that at time 1 in the GIRK inhibition treatment group (p = 0.004) but not in the non-GIRK inhibition treatment group. The results of the present study suggest that GIRK inhibition treatment may improve the positive expectancy for alcohol, a component of relapse risk. The present study suggests that the effects of GIRK inhibition treatment should be investigated further in future studies.
authors: Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors: Nagisa
authors: N
authors: Sugaya
authors: Yasukazu
authors: Y
authors: Ogai
authors: Yoichi
authors: Y
authors: Kakibuchi
authors: Eiichi
authors: E
authors: Senoo
authors: Kazutaka
authors: K
authors: Ikeda
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000188:drug therapy* / Q000517:prevention & control*; D044466:Asian People; D002908:Chronic Disease / Q000188:drug therapy; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007266:Inhibition, Psychological; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D012306:Risk; D055502:Secondary Prevention; D011795:Surveys and Questionnaires
chemical_list: D051676:G Protein-Coupled Inwardly-Rectifying Potassium Channels; D026902:Potassium Channel Blockers; D000431:Ethanol