title: Preclinical models in electrochemotherapy: the role of veterinary patients.
abstract: Electrochemotherapy is a tumor treatment that adapts the systemic or local delivery of anticancer drugs by the application of permeabilizing electric pulses with appropriate amplitude and waveforms. This allows the use of lipophobic drugs, which frequently have a narrow therapeutic index, with a decreased morbidity for the patient, while maintaining appropriate anticancer efficacy. Electrochemotherapy is used in humans for the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, and a standard operating procedure has been devised. In veterinary oncology, the electrochemotherapy approach is gaining popularity, becoming a first-line treatment in consideration of its high efficacy and low toxicity. This review summarizes the state of the art in veterinary oncology as a preclinical model.
authors: SAFU Department, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, Rome 00158, Italy. info@enricospugnini.net
authors: Enrico Pierluigi
authors: EP
authors: Spugnini
authors: Maurizio
authors: M
authors: Fanciulli
authors: Gennaro
authors: G
authors: Citro
authors: Alfonso
authors: A
authors: Baldi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000493:pharmacokinetics / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D002371:Cat Diseases / Q000188:drug therapy; D002415:Cats; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D053672:Electrochemotherapy / Q000379:methods* / Q000662:veterinary; D015251:Epirubicin; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D008545:Melanoma / Q000662:veterinary; D008942:Mitoxantrone / Q000493:pharmacokinetics / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D011799:Quinazolines; D012509:Sarcoma / Q000188:drug therapy; D013876:Thiophenes
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D013876:Thiophenes; D001761:Bleomycin; D015251:Epirubicin; D008942:Mitoxantrone; D002945:Cisplatin