title: Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus.
abstract: The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.
authors: Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors: Dandan
authors: D
authors: Wang
authors: Kentaro
authors: K
authors: Akiyama
authors: Huayong
authors: H
authors: Zhang
authors: Takayoshi
authors: T
authors: Yamaza
authors: Xia
authors: X
authors: Li
authors: Xuebing
authors: X
authors: Feng
authors: Hong
authors: H
authors: Wang
authors: Bingzhu
authors: B
authors: Hua
authors: Bujun
authors: B
authors: Liu
authors: Huji
authors: H
authors: Xu
authors: Wanjun
authors: W
authors: Chen
authors: Songtao
authors: S
authors: Shi
authors: Lingyun
authors: L
authors: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000628:therapy*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D055815:Young Adult