title: Methylenetetrahydrofolate reductase polymorphism (c677t) in Muslim population of eastern Uttar Pradesh, India.
abstract: OBJECTIVE
  The aim of the present study was to investigate the distribution of methylenetetrahydrofolate reductase (C677T) polymorphism in the Muslim population of eastern Uttar Pradesh.
  
  
  METHODS
  Total 56 subjects were analysed for MTHFR C677T polymorphism. C677T mutation analysis was done according to the PCR-RFLP (Polymerase chain reaction-Restriction fragment length polymorphism) method.
  
  
  RESULTS
  The frequencies of three genotypes CC, CT, and TT were 0.857, 0.125, and 0.07, respectively, and the frequency of mutated T allele was found to be 0.080.
  
  
  CONCLUSIONS
  Genotypes and allele frequencies revealed the low prevalence of MTHFR C677T polymorphism in Indin Muslims. C677T mutation has been suggested to be positively associated with the risk of several congenital and multifactorial disorders. The low frequency of T/T genotype in the Muslim population may be due to malnutrition in pregnant women, because of insufficient intake of folate is considered to be a survival disadvantage for foetuses with T/T genotype.
authors: Human Molecular Genetics Laboratory, Department of Biotechnology, VBS Purvanchal University, Jaunpur - 222 001, Uttar Pradesh, India. raivandana@rediffmail.com
authors: Vandana
authors: V
authors: Rai
authors: Upendra
authors: U
authors: Yadav
authors: Pradeep
authors: P
authors: Kumar
authors: Sushil Kumar
authors: SK
authors: Yadav
mesh_terms: D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007194:India / Q000208:ethnology; D007514:Islam; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)