title: A rapidly progressing lymphocyte exhaustion after severe sepsis.
abstract: Septic syndromes induce immune alterations that have long been considered solely an overwhelming pro-inflammatory response. Increasing evidence now suggests that, after the first pro-inflammatory hours, sepsis is accompanied by the occurrence of a systemic immune failure. Here, novel perspectives regarding sepsis-induced lymphocyte alterations will be discussed in the context of a recently published study investigating overtime evolution of co-inhibitory lymphocyte receptor expressions in patients with severe sepsis.
authors: Guillaume
authors: G
authors: Monneret
authors: Fabienne
authors: F
authors: Venet
mesh_terms: D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000639:trends*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D010641:Phenotype; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis*