title: Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.
abstract: Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.
authors: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors: Adam
authors: A
authors: Macneil
authors: Ute
authors: U
authors: Ströher
authors: Eileen
authors: E
authors: Farnon
authors: Shelley
authors: S
authors: Campbell
authors: Deborah
authors: D
authors: Cannon
authors: Christopher D
authors: CD
authors: Paddock
authors: Clifton P
authors: CP
authors: Drew
authors: Matthew
authors: M
authors: Kuehnert
authors: Barbara
authors: B
authors: Knust
authors: Robert
authors: R
authors: Gruenenfelder
authors: Sherif R
authors: SR
authors: Zaki
authors: Pierre E
authors: PE
authors: Rollin
authors: Stuart T
authors: ST
authors: Nichol
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000821:virology; D008099:Liver / Q000473:pathology / Q000821:virology; D008168:Lung / Q000473:pathology / Q000821:virology; D008216:Lymphocytic Choriomeningitis / Q000175:diagnosis / Q000401:mortality / Q000635:transmission* / Q000821:virology*; D008217:Lymphocytic choriomeningitis virus / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014019:Tissue Donors; D014481:United States / Q000453:epidemiology