title: Prenatal management and perinatal outcome in giant placental chorioangioma complicated with hydrops fetalis, fetal anemia and maternal mirror syndrome.
abstract: BACKGROUND
  Giant placental chorioangiomas have been associated with a number of severe fetal complications and high perinatal mortality.
  
  
  METHODS
  We report a case of giant chorioangioma with fetal hydrops, additionally complicated by severe anemia, mild cardiomegaly with hyperdinamic heart circulation and maternal mirror syndrome. Intrauterine blood transfusion and amniodrainage was performed at 29 weeks. Worsening of the fetal and maternal condition prompted us to proceed with delivery at 29 + 5 weeks. The newborn died 3 hours later due to pulmonary hypoplasia and hemodynamic failure. Maternal course was favourable, mirror syndrome resolved in the second day and the patient was discharged four days following delivery.
  
  
  CONCLUSIONS
  In the case described here, fetal condition got worse despite of the anemia correction and amniodrainage. Our outcome raises the issue whether additional intrauterine clinical intervention, as intersticial laser, should have been performed to stop further deterioration of the fetal condition when progressive severe hydrops develops.
authors: Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
authors: Lutgardo
authors: L
authors: García-Díaz
authors: Práxedes
authors: P
authors: Carreto
authors: Susana
authors: S
authors: Costa-Pereira
authors: Guillermo
authors: G
authors: Antiñolo
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications* / Q000628:therapy; D001805:Blood Transfusion, Intrauterine; D006332:Cardiomegaly / Q000150:complications / Q000000981:diagnostic imaging; D002585:Cesarean Section; D004487:Edema; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000628:therapy; D006391:Hemangioma / Q000150:complications* / Q000473:pathology; D048550:Hepatic Insufficiency; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging*; D007008:Hypokalemia; D007019:Hypoproteinemia; D009846:Oliguria; D010922:Placenta Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging* / Q000473:pathology; D013577:Syndrome; D016216:Ultrasonography, Prenatal