title: Azathioprine hypersensitivity presenting as cardiogenic shock and Sweet's syndrome in a patient with microscopic polyangiitis.
abstract: Azathioprine hypersensitivity is a clinical syndrome which may manifest from isolated fever and rash to multi-organ failure. This rare condition is usually self-limiting following the discontinuation of azathioprine. Therefore, it is important to maintain a high index of clinical suspicion for hypersensitivity reactions with azathioprine therapy. We report a case of azathioprine hypersensitivity in a 69-year-old woman who developed cardiogenic shock and Sweet's syndrome following the initiation of azathioprine for her underlying autoantibodies to neutrophil cytoplasmic antigens (ANCA) associated microscopic polyangiitis.
authors: Department of General Medicine, Flinders Medical Centre, Australia.
authors: Arthur
authors: A
authors: Turow
authors: Tuck Y
authors: TY
authors: Yong
authors: Jie Shen
authors: JS
authors: Fok
authors: Jordan Y Z
authors: JY
authors: Li
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001379:Azathioprine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007423:Intra-Aortic Balloon Pumping; D055953:Microscopic Polyangiitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D012770:Shock, Cardiogenic / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D001379:Azathioprine