title: The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
abstract: The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection, but their roles in adaptive immunity have not been clearly defined. Here, we showed that the RLR LGP2 was not essential for induction of innate immune defenses, but rather was required for controlling antigen-specific CD8(+) T cell survival and fitness during peripheral T cell-number expansion in response to virus infection. Adoptive transfer and biochemical studies demonstrated that T cell-receptor signaling induced LGP2 expression wherein LGP2 operated to regulate death-receptor signaling and imparted sensitivity to CD95-mediated cell death. Thus, LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8(+) T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.
authors: Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
authors: Mehul S
authors: MS
authors: Suthar
authors: Hilario J
authors: HJ
authors: Ramos
authors: Margaret M
authors: MM
authors: Brassil
authors: Jason
authors: J
authors: Netland
authors: Craig P
authors: CP
authors: Chappell
authors: Gabriele
authors: G
authors: Blahnik
authors: Aimee
authors: A
authors: McMillan
authors: Michael S
authors: MS
authors: Diamond
authors: Edward A
authors: EA
authors: Clark
authors: Michael J
authors: MJ
authors: Bevan
authors: Michael
authors: M
authors: Gale
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology; D002470:Cell Survival / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D016899:Interferon-beta / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D020365:RNA Helicases / Q000276:immunology*; D012367:RNA, Viral / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014901:West Nile Fever / Q000276:immunology; D014902:West Nile virus / Q000276:immunology; D019014:fas Receptor / Q000276:immunology
chemical_list: D012367:RNA, Viral; D019014:fas Receptor; D016899:Interferon-beta; C547666:Dhx58 protein, mouse; D020365:RNA Helicases