title: An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo.
abstract: An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein 27 siRNA and produce potent gene silencing and anticancer activity in vitro and in vivo in a prostate cancer model. This dendrimer can be used alternatively for treating various diseases.
authors: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, China.
authors: Tianzhu
authors: T
authors: Yu
authors: Xiaoxuan
authors: X
authors: Liu
authors: Anne-Laure
authors: AL
authors: Bolcato-Bellemin
authors: Yang
authors: Y
authors: Wang
authors: Cheng
authors: C
authors: Liu
authors: Patrick
authors: P
authors: Erbacher
authors: Fanqi
authors: F
authors: Qu
authors: Palma
authors: P
authors: Rocchi
authors: Jean-Paul
authors: JP
authors: Behr
authors: Ling
authors: L
authors: Peng
mesh_terms: D050091:Dendrimers / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D020868:Gene Silencing; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000008:administration & dosage* / Q000737:chemistry* / Q000235:genetics; D055551:HSP27 Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics / Q000628:therapy; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry* / Q000235:genetics
chemical_list: D050091:Dendrimers; D055551:HSP27 Heat-Shock Proteins; C104700:PAMAM Starburst; D034741:RNA, Small Interfering