title: Treatment of tuberculosis with levofloxacin or moxifloxacin: report of 6 pediatric cases.
abstract: We report 6 pediatric cases of tuberculosis caused by Mycobacterium tuberculosis and treated them with levofloxacin or moxifloxacin in the mother-child unit of a university hospital in France between 2005 and 2011. We assess the clinical efficacy and safety of fluoroquinolones and the benefit-risk ratio for their use as second-line antituberculosis drugs in children and adolescents.
authors: Service de Pharmacie, Hôpital Robert Debré, AP-HP, 48 Boulevard Sérurier, 75935 Paris Cedex 19, France.
authors: Jean-Vannak
authors: JV
authors: Chauny
authors: Mathie
authors: M
authors: Lorrot
authors: Sonia
authors: S
authors: Prot-Labarthe
authors: Agathe
authors: A
authors: De Lauzanne
authors: Catherine
authors: C
authors: Doit
authors: Tina
authors: T
authors: Géréral
authors: Olivier
authors: O
authors: Bourdon
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001372:Aza Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D024841:Fluoroquinolones; D005602:France; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D064704:Levofloxacin; D008297:Male; D000077266:Moxifloxacin; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification*; D015242:Ofloxacin / Q000008:administration & dosage* / Q000009:adverse effects; D011804:Quinolines / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D064704:Levofloxacin; D015242:Ofloxacin; D000077266:Moxifloxacin