title: Comparative study of intraperitoneal adhesions associated with the use of meshes of polypropylene and polypropylene coated with omega-3 fatty acid.
abstract: OBJECTIVE
  To compare intraperitoneal adhesion formation with placement of polypropylene mesh and use of lightweight polypropylene mesh coated with omega-3 fatty in rats.
  
  
  METHODS
  Twenty-seven Wistar rats were randomized into three groups. In group 0 no mesh was placed; in group 1 we implanted a polypropylene mesh; and in group 2 there was implantation of a polypropylene mesh coated with omega-3 fatty acid. We evaluated adhesions presence and degree, breaking strength, percentage of area covered and retraction of the implanted meshes.
  
  
  RESULTS
  Group 0 had no adhesion. Groups 1 and 2 showed adhesions on the surface of the mesh, omentum, liver and intestinal loops. There were grades 1 and 2 adhesions in 100% of the polypropylene coated group and in 60% of the polypropylene group. The remaining were grade 3 adhesions, and differed significantly between groups (p <0.001). The breaking strength of adhesions on the polypropylene coated group was significantly higher than with the polypropylene alone (p = 0.016). There was no difference in mesh retraction or area covered by the mesh. The analysis of the mesh coated with omega-3 fatty acid distribution showed adhesions preferentially located at the edges when compared to polypropylene, predominantly in the center.
  
  
  CONCLUSIONS
  The type of adhesions, percentage of surface affected and retraction were not significantly different between meshes. The fatty acids coated mesh had a lower degree of adhesions and these required a greater force to rupture, possibly by their occurrence at the edges of the mesh.
authors: General Surgery - University of Caxias do Sul--UCS, Brazil.
authors: Caroline
authors: C
authors: Kist
authors: Bibiana Borges
authors: BB
authors: Manna
authors: Juliano Hermes Maeso
authors: JH
authors: Montes
authors: André Vicente
authors: AV
authors: Bigolin
authors: João Vicente Machado
authors: JV
authors: Grossi
authors: Leandro Totti
authors: LT
authors: Cavazzola
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D004867:Equipment Design; D015525:Fatty Acids, Omega-3; D010532:Peritoneal Diseases / Q000209:etiology*; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D020099:Coated Materials, Biocompatible; D015525:Fatty Acids, Omega-3; D011126:Polypropylenes