title: Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether tumor necrosis factor superfamily 4 (TNFSF4) and TNF receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE).
  
  
  METHODS
  The authors conducted meta-analyses on associations between polymorphisms of the TNFSF4 (rs2205960, rs1234315, rs10489265) and TRAF1-C5 (rs10818488, rs3761847) genes and SLE susceptibility, using fixed and random effects models.
  
  
  RESULTS
  A total of 21 comparative studies were included in this meta-analysis; meta-analysis showed an association between the minor allele of rs2205960 of TNFSF4 and SLE in all study subjects (odds ratio [OR]=1.356, 95% confidence interval [CI]=1.275-1.442, p<1.0×10(-9)). Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)). The minor allele of rs10818488 of TRAF1-C5 was found to be significantly associated with SLE in Europeans (OR=1.210, 95% CI=1.115-1.313, p=5.0×10(-6)). The association p-values remained significant after multiple corrections.
  
  
  CONCLUSIONS
  This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans. An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to SLE in Europeans.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, 126-1 Seoul, Republic of Korea. lyhcgh@korea.ac.kr
authors: Young Ho
authors: YH
authors: Lee
authors: Gwan Gyu
authors: GG
authors: Song
mesh_terms: D044466:Asian People / Q000235:genetics*; D003182:Complement C5 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D047990:TNF Receptor-Associated Factor 1 / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: D003182:Complement C5; D053278:OX40 Ligand; D047990:TNF Receptor-Associated Factor 1; C089251:TNFSF4 protein, human