title: A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)-induced Aβ aggregation.
abstract: The synthesis of the H(2)L(2-) ligand (N,N'-Bis[(5-sulfonato-2-hydroxy)benzyl]-N,N'-dimethyl-ethane-1,2-diamine) and characterizations of the corresponding Cu(II) complex [Cu(L)(H(2)O)](2-) (1) by X-ray diffraction, EPR, UV-Visible and potentiometry are described. At pH 7.4, the affinity of Cu(II) for this ligand is approximately 4 × 10(14)M(-1). Coordination of redox active metal ions such as copper or iron to the amyloid-β (Aβ) peptide has been linked to deleterious processes encountered in the etiology of Alzheimer disease (AD), such as Aβ aggregation and reactive oxygen species (ROS) production. In this context, the ability of the H(2)L(2-) to extract Cu(II) from Cu(Aβ) species where Aβ is the peptide involved in AD, is reported as well as its capacity to redox silence the Cu(Aβ) induced ROS formation and to prevent Cu(II)-induced Aβ aggregation. Such water soluble sulfonato-derivatives of Cu(II) chelators are very interesting counterparts for in vitro study of chelators' properties required to attend further biological applications as therapeutic tools against AD.
authors: CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France.
authors: Sabrina
authors: S
authors: Noël
authors: Fabien
authors: F
authors: Perez
authors: Jeppe T
authors: JT
authors: Pedersen
authors: Bruno
authors: B
authors: Alies
authors: Sonia
authors: S
authors: Ladeira
authors: Stéphanie
authors: S
authors: Sayen
authors: Emmanuel
authors: E
authors: Guillon
authors: Emmanuel
authors: E
authors: Gras
authors: Christelle
authors: C
authors: Hureau
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D001557:Benzenesulfonates; D002614:Chelating Agents; D005029:Ethylenediamines; C583565:N,N'-bis((5-sulfonato-2-hydroxy)benzyl)-N,N'-dimethylethane-1,2-diamine; D017382:Reactive Oxygen Species; D014867:Water; D003300:Copper; D010100:Oxygen