title: Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
abstract: As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.
authors: Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale A. Avogadro, Largo Donegani 2, 28100 Novara, Italy.
authors: Ubaldina
authors: U
authors: Galli
authors: Ornella
authors: O
authors: Mesenzani
authors: Camilla
authors: C
authors: Coppo
authors: Giovanni
authors: G
authors: Sorba
authors: Pier Luigi
authors: PL
authors: Canonico
authors: Gian Cesare
authors: GC
authors: Tron
authors: Armando A
authors: AA
authors: Genazzani
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009536:Niacinamide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors*; D056565:Sirtuin 2 / Q000037:antagonists & inhibitors*; D056566:Sirtuin 3 / Q000037:antagonists & inhibitors*; D013379:Substrate Specificity
chemical_list: D056572:Histone Deacetylase Inhibitors; D009536:Niacinamide; D056564:Sirtuin 1; D056565:Sirtuin 2; D056566:Sirtuin 3