title: Mechanisms of simple hepatic steatosis: not so simple after all.
abstract: Nonalcoholic fatty liver disease is becoming an epidemic. Fat is typically stored in adipose tissue in the form of triglycerides (TGs). The deposition of TGs in the liver is the result of an imbalance between the amount of energy taken in and the amount used. This balance is maintained by a complex interplay between the dietary intake of nutrients, the hormonal response to the nutrients, and their effect on both the liver and adipose tissue. Disruption of this system is what leads to the development of steatosis and is the focus of this article.
authors: Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, 23298, USA.
authors: Scott C
authors: SC
authors: Matherly
authors: Puneet
authors: P
authors: Puri
mesh_terms: D000818:Animals; D004032:Diet; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism*; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008297:Male; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease; D051381:Rats; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D007328:Insulin; D005947:Glucose