title: Ready…aim…fire into the lumen: a new role for enterocyte microvilli in gut host defense.
abstract: Recent studies from our laboratory revealed that enterocyte brush border microvilli release small vesicles laden with host defense machinery into the intestinal lumen. In this addendum, we introduce a multi-faceted model for the function of these lumenal vesicles in the gut; we also consider some of the important unanswered questions that must be addressed in order to develop our understanding of this novel aspect of innate intestinal immunity.
authors: Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: David A
authors: DA
authors: Shifrin
authors: Matthew J
authors: MJ
authors: Tyska
mesh_terms: D000818:Animals; D020895:Enterocytes / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008871:Microvilli / Q000276:immunology*; D008954:Models, Biological; D022142:Secretory Vesicles / Q000276:immunology