title: Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma.
abstract: The aim of this study was to evaluate the effect of advanced glaucoma on locomotor activity rhythms and related sleep parameters. Nine normal subjects and nine age-matched patients with bilateral advanced primary open-angle glaucoma, >10 yrs since diagnosis, were included in this observational, prospective, case-control study. Patients were required to record the timing and duration of their sleep and daily activities, and wore an actigraph on the wrist of the nondominant arm for 20 d. Activity rhythm period, MESOR (24-h time-series mean), amplitude (one-half peak-to-trough variation), and acrophase (peak time), plus long sleep episodes during the wake state, sleep duration, efficiency, and latency, as well as mean activity score, wake minutes, and mean wake episodes during the sleep interval were assessed in controls and glaucomatous patients. Glaucomatous patients exhibited significant decrease in nighttime sleep efficiency, and significant increase in the mean activity score, wake minutes, and mean wake episode during the night. These results suggest that alterations of circadian physiology could be a risk to the quality of life of patients with glaucoma.
authors: Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Human Biochemistry, School of Medicine, University of Buenos Aires/CEFyBO, CONICET, Buenos Aires, Argentina.
authors: María Florencia
authors: MF
authors: Lanzani
authors: Nuria
authors: N
authors: de Zavalía
authors: Héctor
authors: H
authors: Fontana
authors: María Ines Keller
authors: MI
authors: Sarmiento
authors: Diego
authors: D
authors: Golombek
authors: Ruth E
authors: RE
authors: Rosenstein
mesh_terms: D056044:Actigraphy; D000368:Aged; D016022:Case-Control Studies; D021081:Chronobiology Disorders / Q000209:etiology / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011788:Quality of Life; D012165:Retinal Ganglion Cells / Q000502:physiology; D012307:Risk Factors; D017299:Rod Opsins / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology / Q000503:physiopathology; D000099210:Melanopsin
chemical_list: D017299:Rod Opsins; D000099210:Melanopsin