title: Effects of growth factors on dental stem/progenitor cells.
abstract: The primary goal of regenerative endodontics is to restore the vitality and functions of the dentin-pulp complex, as opposed to filing of the root canal with bioinert materials. A myriad of growth factors regulates multiple cellular functions including migration, proliferation, differentiation, and apoptosis of several cell types intimately involved in dentin-pulp regeneration. Recent work showing that growth factor delivery, without cell transplantation, can yield pulp-dentin-like tissues in vivo provides one of the tangible pathways for regenerative endodontics. This review synthesizes knowledge on many growth factors that are known or anticipated to be efficacious in dental pulp-dentin regeneration.
authors: Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032, USA.
authors: Sahng G
authors: SG
authors: Kim
authors: Jian
authors: J
authors: Zhou
authors: Charles
authors: C
authors: Solomon
authors: Ying
authors: Y
authors: Zheng
authors: Takahiro
authors: T
authors: Suzuki
authors: Mo
authors: M
authors: Chen
authors: Songhee
authors: S
authors: Song
authors: Nan
authors: N
authors: Jiang
authors: Shoko
authors: S
authors: Cho
authors: Jeremy J
authors: JJ
authors: Mao
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects* / Q000502:physiology; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects*; D003804:Dentin / Q000166:cytology / Q000187:drug effects*; D004708:Endodontics / Q000379:methods; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins