title: Spectral CT imaging of myocardial infarction: preliminary animal experience.
abstract: OBJECTIVE
  To evaluate the capability of spectral CT imaging to detect the different stages and angiogenesis of myocardial infarction (MI).
  
  
  METHODS
  MI was surgically induced in 40 rabbits that were evenly divided into four stages of MI: 6 h (6H), 3 days (3D), 7 days (7D) and 14 days (14D). Spectral CT was performed at 10 s, 1 min and 3 min after intravenous contrast medium administration. CD31 immunohistochemistry was used for the microvessel density (MVD) measurement. Iodine concentrations in the myocardium were measured and normalised to the aorta as nIC. The relationships between infarcted myocardial nIC and MVD were analysed.
  
  
  RESULTS
  The nIC of infarct myocardium decreased at 10 s and increased in late-phase CT images. There were significant differences between the 6H and other groups (P ( 6H-3D )  = 0.01, P ( 6H-7D )  = 0.01, P ( 6H-14D )  = 0.00). There was a significant difference in the MVD of infarct myocardium between the two groups except in the 7D and 14D groups (P = 0.08). In the 10-s phase, the nIC of infarct myocardium was negatively correlated with MVD (r = -0.54, P = 0.00), whereas in the late phases, there was a positive correlation between them (r = 0.57, P = 0.00 in the 1-min phase, r = 0.48, P = 0.00 in the 3-min phase).
  
  
  CONCLUSIONS
  Spectral CT imaging of the myocardium can be used to evaluate the different stages and angiogenesis of MI.
authors: Department of Radiology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, No. 197, Ruijin 2nd, Road, Shanghai, 200025, China.
authors: Li-fang
authors: LF
authors: Pang
authors: Huan
authors: H
authors: Zhang
authors: Wei
authors: W
authors: Lu
authors: Wen-jie
authors: WJ
authors: Yang
authors: Hua
authors: H
authors: Xiao
authors: Wei-qing
authors: WQ
authors: Xu
authors: Ying
authors: Y
authors: Chen
authors: Yan
authors: Y
authors: Liu
authors: Yu-lian
authors: YL
authors: Bu
authors: Zi-lai
authors: ZL
authors: Pan
authors: Ke-min
authors: KM
authors: Chen
authors: Fu-hua
authors: FH
authors: Yan
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011817:Rabbits; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media