title: A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: the Lipid Treatment Assessment Project 2.
abstract: OBJECTIVE
  This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study.
  
  
  METHODS
  9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries.
  
  
  RESULTS
  Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p < 0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America.
  
  
  CONCLUSIONS
  Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.
authors: The Lipid Clinic Heart Institute (InCor), University of São Paulo Hospital, São Paulo, Brazil. raul.santos@incor.usp.br
authors: Raul D
authors: RD
authors: Santos
authors: David D
authors: DD
authors: Waters
authors: Lisa
authors: L
authors: Tarasenko
authors: Michael
authors: M
authors: Messig
authors: J Wouter
authors: JW
authors: Jukema
authors: Cheng-Wen
authors: CW
authors: Chiang
authors: Jean
authors: J
authors: Ferrieres
authors: Joanne M
authors: JM
authors: Foody
mesh_terms: D000328:Adult; D000368:Aged; D002170:Canada; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000188:drug therapy*; D050171:Dyslipidemias / Q000188:drug therapy*; D005060:Europe; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007843:Latin America; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014481:United States
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D014280:Triglycerides