title: [Low-affinity Fcγ receptor IIa gene polymorphism and dengue bleeding disorder].
abstract: BACKGROUND
  The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic.
  
  
  METHODS
  We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered dengue infection in 2006, using contingency tables.
  
  
  RESULTS
  We found that bleeding was significantly associated to FcγRIIa H/H131 genotype (80%).
  
  
  CONCLUSIONS
  Our results suggest that in clinical dengue infection the bleeding could be associated to FcγRIIa H/H131 genotype.
authors: Departamento de Virología, Centro Colaborador para el estudio del Dengue y su Vector, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba. gmd@ipk.sld.cu
authors: Gissel
authors: G
authors: García
authors: Daniel
authors: D
authors: González
authors: Lizet
authors: L
authors: Sánchez
authors: Ana B
authors: AB
authors: Pérez
authors: Beatriz
authors: B
authors: Sierra
authors: María G
authors: MG
authors: Guzmán
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D012189:Retrospective Studies; D019595:Severe Dengue / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D013921:Thrombocytopenia / Q000209:etiology; D055815:Young Adult
chemical_list: C445323:FCGR2A protein, human; D017452:Receptors, IgG