title: Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives.
abstract: The mycalamide class of potent antiviral and antitumor natural compounds originally isolated from marine sponges in 1988 is a new interdisciplinary approach to molecular recognition. We review new synthetic approaches to this new family of natural products with remarkable biological activity. Some biological evaluation data are compiled and compared to other structurally similar molecular targets.
authors: Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, PA 18766, USA. zbigniew.witczak@wilkes.edu
authors: Zbigniew J
authors: ZJ
authors: Witczak
authors: Ricky M
authors: RM
authors: Rampulla
authors: Ajay
authors: A
authors: Bommareddy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D001517:Coleoptera / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011161:Porifera / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D003374:Coumarins; D011714:Pyrans; C059647:mycalamide B; C498383:psymberin; C059646:mycalamide A; C100127:pederin