title: Implication of liver cardiolipins in mitochondrial energy metabolism disorder in cancer cachexia.
abstract: Mitochondrial membranes are essential for the good functioning of the organelle. For instance, the inner mitochondrial membrane contains the oxidative phosphorylation system that permits ATP synthesis. Phospholipids environment and especially cardiolipin are crucial for the mitochondrial energy metabolism. Indeed, cardiolipin is known to provide essential structural and functional support to several proteins involved in oxidative phosphorylation. Alterations in cardiolipin structure, content and fatty acids composition have been associated with mitochondrial dysfunction in several physiopathological conditions and diseases. Cancer cachexia is a complex and dynamic process characterized by a negative energy balance induced by anorexia and hypermetabolism which leads to a drastic loss in body weight that aggravate prognosis of cancer patients. The underlying mechanisms of hypermetabolism are not fully understood. Whether the mitochondrial energy metabolism is altered during this disease and may participate to hypermetabolism is not clear. This mini-review focuses on cardiolipin especially its biosynthesis and remodeling pathways, its relation with mitochondrial energy metabolism and its possible implication in the cancer cachexia syndrome.
authors: INSERM UMR1069, "Nutrition, Growth and Cancer", Tours, France. jean-francois.dumas@univ-tours.fr
authors: Jean-François
authors: JF
authors: Dumas
authors: Laure
authors: L
authors: Peyta
authors: Charles
authors: C
authors: Couet
authors: Stéphane
authors: S
authors: Servais
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis / Q000737:chemistry; D000855:Anorexia / Q000378:metabolism / Q000473:pathology; D002100:Cachexia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D002308:Cardiolipins / Q000737:chemistry / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008930:Mitochondria, Liver / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000473:pathology; D051336:Mitochondrial Membranes / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology; D010085:Oxidative Phosphorylation
chemical_list: D002308:Cardiolipins; D000255:Adenosine Triphosphate