title: [Enhancing the immunogenic activity of influvac vaccine in the use of adjuvant TI complexes modified by echinochrome A].
abstract: The self-assembly of marine macrophyte glycolipids, holothurian saponin, and cholesterol gave rise to nanoscale morphological structures called tubular immunostimulating (TI) complexes. Whether the latter could be used on the basis of vaccine preparations containing the influenza virus subunit antigens was studied. There was an obvious increase in the immunogenicity of influenza virus hemagglutinin when the experimental animals were immunized with this antigen as part of TI complexes. It was shown that the adjuvant activity of the TI complex to influenza virus hemagglutinin could be enhanced by adding the known antioxidant echinochrome A from a sand-dollar (Echinarachnius parma) to the matrix of the TI complex.
authors: A V
authors: AV
authors: Tsybul'skiĭ
authors: A M
authors: AM
authors: Popov
authors: A A
authors: AA
authors: Artiukov
authors: A N
authors: AN
authors: Mazeĭka
authors: É  Ia
authors: É
authors: Kostetskiĭ
authors: N M
authors: NM
authors: Sanina
authors: O N
authors: ON
authors: Krivoshapko
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D038983:Galactolipids / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D016882:ISCOMs / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D009285:Naphthoquinones / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D044445:Ulva / Q000737:chemistry; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D038983:Galactolipids; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D016882:ISCOMs; D007252:Influenza Vaccines; D009285:Naphthoquinones; D012503:Saponins; C539161:cucumarioside A2-2; C568705:influvac; C009909:monogalactosyldiacylglycerol; C007573:echinochrome A