title: Cytotoxic T-lymphocyte associated antigen 4 polymorphisms and asthma risk: a meta-analysis.
abstract: BACKGROUND
  A number of studies assessed the association of cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms with asthma in different populations. However, the results were contradictory. We performed a meta-analysis to examine the association between CTLA-4 polymorphisms and asthma susceptibility.
  
  
  METHODS
  Pubmed, EMBASE, HuGE Navigator, and Wanfang Database were searched. Data were extracted independently by two reviewers. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.
  
  
  RESULTS
  Seventeen studies involving 6378 cases and 8674 controls were included. Significant association between +49 A/G polymorphism and asthma was observed for AA vs. AG+GG (OR = 1.18, 95% CI 1.01-1.37, P = 0.04). There were no significant associations between -318 C/T, -1147 C/T, CT60 A/G, -1722 C/T, or rs926169 polymorphisms and asthma risk.
  
  
  CONCLUSIONS
  This meta-analysis suggested that the +49 A/G polymorphism in CTLA-4 was a risk factor for asthma.
authors: Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors: Wei
authors: W
authors: Nie
authors: Jiquan
authors: J
authors: Chen
authors: Qingyu
authors: Q
authors: Xiu
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics*; D060908:CTLA-4 Antigen / Q000235:genetics*; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D060908:CTLA-4 Antigen