title: Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).
abstract: A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic system gave α-aminonitriles in excellent yields (up to 95%) and high enantioselectivities (er up to 94:6). The efficacy of the chiral product was successfully fulfilled in the improved synthesis of (S)-clopidogrel (an antiplatelet agent).
authors: Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific & Industrial Research (CSIR), G. B. Marg, Bhavnagar-364 021, Gujarat, India.
authors: Arghya
authors: A
authors: Sadhukhan
authors: S
authors: S
authors: Saravanan
authors: Noor-ul H
authors: NU
authors: Khan
authors: Rukhsana I
authors: RI
authors: Kureshy
authors: Sayed H R
authors: SH
authors: Abdi
authors: Hari C
authors: HC
authors: Bajaj
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D000077144:Clopidogrel; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis*; D011802:Quinidine / Q000031:analogs & derivatives* / Q000737:chemistry; D012969:Sodium Fluoride / Q000737:chemistry; D013237:Stereoisomerism; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D000447:Aldehydes; D000588:Amines; D010975:Platelet Aggregation Inhibitors; C014486:hydroquinidine; D012969:Sodium Fluoride; D000077144:Clopidogrel; D011802:Quinidine; D013988:Ticlopidine