title: Does a single endometrial biopsy regimen (S-EBR) improve ICSI outcome in patients with repeated implantation failure? A randomised controlled trial.
abstract: OBJECTIVE
  To evaluate the effect of a single endometrial biopsy regimen (S-EBR) in the cycle preceding the ICSI cycle in patients with repeated implantation failure.
  
  
  METHODS
  This was a prospective randomized controlled trial which included two-hundred infertile women with a history of repeated implantation failure. The subjects were randomly divided into two groups. Group A subjects underwent hysteroscopy and endometrial scraping by Novak curette in the cycle preceding the ICSI cycle, while group B subjects underwent hysteroscopy without endometrial scraping. Implantation rate, clinical pregnancy rate, abortion rate and live birth rate were compared between both groups.
  
  
  RESULTS
  The number of retrieved oocytes in group A was 11.6 ± 3 and in group B was 11.6 ± 2.8 with no statistically significant difference (p=0.787). There were statistically significant differences regarding the implantation rate, the clinical pregnancy rate and live birth rate. The implantation rate in group A was 12% while in group B it was 7% (p=0.015), the clinical pregnancy rate was 32% in group A while it was only 18% in group B (p=0.034) and the live birth rate was 28% in group A while it was 14% in group B (p=0.024).
  
  
  CONCLUSIONS
  The single endometrial biopsy regimen (S-EBR) performed during hysteroscopy has statistically significant higher implantation rate, clinical pregnancy rate and live birth rate than hysteroscopy without endometrial scraping.
authors: IVF Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt; Samir Abbas IVF Center, Jeddah, Saudi Arabia.
authors: Amal
authors: A
authors: Shohayeb
authors: Waleed
authors: W
authors: El-Khayat
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D001706:Biopsy; D004107:Dilatation and Curettage / Q000009:adverse effects*; D004534:Egypt / Q000453:epidemiology; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007246:Infertility / Q000628:therapy; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy*; D050498:Live Birth; D010352:Patient Dropouts; D011247:Pregnancy; D018873:Pregnancy Rate; D012529:Saudi Arabia / Q000453:epidemiology; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure