title: Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity.
abstract: Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
authors: Center for Biomaterial Development, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht GmbH and Berlin-Brandenburg Centre for Regenerative Therapies, Kantstr 55, 14513 Teltow, Germany.
authors: Maik
authors: M
authors: Lange
authors: Steffen
authors: S
authors: Braune
authors: Karola
authors: K
authors: Luetzow
authors: Klaus
authors: K
authors: Richau
authors: Nico
authors: N
authors: Scharnagl
authors: Marie
authors: M
authors: Weinhart
authors: Axel T
authors: AT
authors: Neffe
authors: Friedrich
authors: F
authors: Jung
authors: Rainer
authors: R
authors: Haag
authors: Andreas
authors: A
authors: Lendlein
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D002448:Cell Adhesion; D005990:Glycerol / Q000737:chemistry*; D008567:Membranes, Artificial; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D011506:Proteins; C433673:polyetherimide; C043941:polyglycerol; D005990:Glycerol