title: [Impact of enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBLE) incidence increasing on barrier precautions implementation in a university hospital].
abstract: OBJECTIVE
  The French national surveillance program of multidrug-resistant bacteria (MDR) shows an increase of enterobacteriaceae-producing extended-spectrum beta-lactamases (ESBLE) incidence. The objectives of this study were to assess: the incidence of EBLSE in a large French university hospital between 2005 and 2010, and the difference of barrier precautions implementation between ESBL and other MDR.
  
  
  METHODS
  The ESBLE incidence measure used data from the laboratory of bacteriology. The application of isolation and barrier precautions was analyzed from the MRB national surveillance data over a 3-year period from 2006 to 2008. Data were entered and analyzed using Epi Info software. The Chi(2) test was used for the comparison of proportions.
  
  
  RESULTS
  The overall incidence of ESBLE was significantly higher in 2010 than in 2005 (0.20/1000 patients-days vs 0.03/1000 patients-days, respectively) (P<0.001). The same was observed for Escherichia coli incidence with rates ranging from 0.02/1000 patients-days in 2005 to 0.15/1000 patients-days in 2010. Isolation precautions for patients with EBLSE were applied in relation for most patients with MRB (ESBLE vs others), without significant difference.
  
  
  CONCLUSIONS
  The surveillance programme of MRB showed a significant increase of ESBLE, especially for E. coli. Isolation and barrier precautions were used for most patients with MRB, including ESBLE.
authors: Unité de gestion du risque infectieux, service de bactériologie-hygiène, Le Tourville, 5, rue du Pr-Yves-Boquien, 44093 Nantes cedex 01, France. Electronic address: celine.bourigault@chu-nantes.fr.
authors: C
authors: C
authors: Bourigault
authors: S
authors: S
authors: Corvec
authors: P
authors: P
authors: Bemer
authors: M-E
authors: ME
authors: Juvin
authors: A
authors: A
authors: Guillouzouic
authors: L
authors: L
authors: Crémet
authors: A
authors: A
authors: Reynaud
authors: C
authors: C
authors: Leprince
authors: D
authors: D
authors: Lepelletier
mesh_terms: D003428:Cross Infection / Q000382:microbiology; D018432:Drug Resistance, Multiple; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D004927:Escherichia coli Infections / Q000453:epidemiology; D005602:France / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D017053:Infection Control; D010356:Patient Isolation; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001618:beta-Lactamases