title: Role of AGC kinases in plant growth and stress responses.
abstract: AGC kinases are important regulators of cell growth, metabolism, division, and survival in mammalian systems. Mutation or deregulation of members of this family of protein kinases contribute to the pathogenesis of many human diseases, including cancer and diabetes. Although AGC kinases are conserved in the plant kingdom, little is known about their molecular functions and targets. Some of the best-studied plant AGC kinases mediate auxin signaling and are thereby involved in the regulation of growth and morphogenesis. Furthermore, certain members are regulated by lipid-derived signals via the 3-phosphoinositide-dependent kinase 1 (PDK1) and the kinase target of rapamycin (TOR), similar to its animal counterparts. In this review, we discuss recent findings on plant AGC kinases that unravel important roles in the regulation of plant growth, immunity and cell death, and connections to stress-induced mitogen-activated protein kinase signaling cascades.
authors: URGV Unité de Recherche en Génomique Végétale, UMR, ERL, INRA-UEVE-CNRS, Evry, France.
authors: Ana Victoria
authors: AV
authors: Garcia
authors: Mohamed
authors: M
authors: Al-Yousif
authors: Heribert
authors: H
authors: Hirt
mesh_terms: D064413:3-Phosphoinositide-Dependent Protein Kinases; D017360:Arabidopsis / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000378:metabolism; D001487:Basidiomycota / Q000502:physiology; D016923:Cell Death; D020935:MAP Kinase Signaling System; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D063245:Plant Development; D010944:Plants / Q000201:enzymology* / Q000276:immunology; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D013312:Stress, Physiological; D013559:Symbiosis
chemical_list: D064413:3-Phosphoinositide-Dependent Protein Kinases; D029681:Arabidopsis Proteins; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C512171:TOR protein, Arabidopsis; C578562:PDPK1 protein, human