title: Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout.
abstract: To examine the behavior of the estrogenic biomarker vitellogenin (VTG) under the combined impact of estrogens and pathogens, parasite-infected or noninfected rainbow trout were exposed to two doses of 17β-estradiol (E2). Infected and E2-exposed fish showed significantly lower hepatic VTG mRNA levels than healthy fish. Transcriptome data suggest that this was due to energetic constraints. Reduced responsiveness of the VTG biomarker in parasitized fish might obscure detection of low-level field exposure.
authors: Centre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
authors: Richard
authors: R
authors: Burki
authors: Aleksei
authors: A
authors: Krasnov
authors: Kathrin
authors: K
authors: Bettge
authors: Caird E
authors: CE
authors: Rexroad
authors: Sergej
authors: S
authors: Afanasyev
authors: Mia
authors: M
authors: Antikainen
authors: Patricia
authors: P
authors: Burkhardt-Holm
authors: Thomas
authors: T
authors: Wahli
authors: Helmut
authors: H
authors: Segner
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D004958:Estradiol / Q000494:pharmacology*; D005393:Fish Diseases / Q000469:parasitology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D055764:Myxozoa / Q000472:pathogenicity; D020411:Oligonucleotide Array Sequence Analysis; D017686:Oncorhynchus mykiss / Q000378:metabolism* / Q000469:parasitology*; D012333:RNA, Messenger; D013312:Stress, Physiological; D059467:Transcriptome; D014819:Vitellogenins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D012333:RNA, Messenger; D014819:Vitellogenins; D004958:Estradiol