title: Identification of novel markers of mouse fetal ovary development.
abstract: In contrast to the developing testis, molecular pathways driving fetal ovarian development have been difficult to characterise. To date no single master regulator of ovarian development has been identified that would be considered the female equivalent of Sry. Using a genomic approach we identified a number of novel protein-coding as well as non-coding genes that were detectable at higher levels in the ovary compared to testis during early mouse gonad development. We were able to cluster these ovarian genes into different temporal expression categories. Of note, Lrrc34 and AK015184 were detected in XX but not XY germ cells before the onset of sex-specific germ cell differentiation marked by entry into meiosis in an ovary and mitotic arrest in a testis. We also defined distinct spatial expression domains of somatic cell genes in the developing ovary. Our data expands the set of markers of early mouse ovary differentiation and identifies a classification of early ovarian genes, thus providing additional avenues with which to dissect this process.
authors: Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia.
authors: Huijun
authors: H
authors: Chen
authors: James S
authors: JS
authors: Palmer
authors: Rathi D
authors: RD
authors: Thiagarajan
authors: Marcel E
authors: ME
authors: Dinger
authors: Emmanuelle
authors: E
authors: Lesieur
authors: Hansheng
authors: H
authors: Chiu
authors: Alexandra
authors: A
authors: Schulz
authors: Cassy
authors: C
authors: Spiller
authors: Sean M
authors: SM
authors: Grimmond
authors: Melissa H
authors: MH
authors: Little
authors: Peter
authors: P
authors: Koopman
authors: Dagmar
authors: D
authors: Wilhelm
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D005819:Genetic Markers / Q000235:genetics*; D008297:Male; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010053:Ovary / Q000196:embryology*; D012727:Sex Characteristics; D013737:Testis / Q000196:embryology
chemical_list: D005819:Genetic Markers