title: [Magnesium and cardiac function].
abstract: Free magnesium ion (Mg(2 + )) is involved in numerous processes of cardiac function. However, mechanism of regulation by Mg(2 + ) has not been fully understood. Extracellular Mg(2 + ) can act on the external surface of the cell membrane, whereas intracellular Mg(2 + ) can exert its effects via many different sites : various enzymes, intracellular organella and internal surface of the cell membrane. In this article, we will briefly review the extracellular and intracellular effects of Mg(2 + ) on each step of E-C coupling of cardiac myocytes, in an attempt to integrate them into cardiac function.
authors: Department of Physiology, Tokyo Medical University, Japan.
authors: Masato
authors: M
authors: Konishi
authors: Michiko
authors: M
authors: Tashiro
authors: Hana
authors: H
authors: Inoue
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D003285:Contractile Proteins / Q000378:metabolism; D000242:Cyclic AMP / Q000502:physiology; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D007477:Ions; D008274:Magnesium / Q000378:metabolism / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology
chemical_list: D015220:Calcium Channels; D003285:Contractile Proteins; D007477:Ions; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium