title: Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia.
abstract: OBJECTIVE
  Although the exact genes involved in preeclampsia (PE) are still not fully discovered, an important role for oxidative stress in its pathogenesis is accepted. XRCC1 (MIM: 194360) and XRCC7 (MIM: 600899) play a crucial role in the DNA repair pathways. Functional polymorphisms in XRCC1 (Arg194Trp and Arg399Gln) and XRCC7 (G6721T) may be risk factors for PE. In the present study, the association between the genetic polymorphisms of XRCC1 and XRCC7 and risk of PE is investigated.
  
  
  METHODS
  The present case-control study was performed on 151 preeclapmtic patients, and a total of 344 normal pregnant women, as a control group. Control women had no history of pregnancies with PE.
  
  
  RESULTS
  Neither polymorphism of Arg194Trp XRCC1 nor polymorphism of G6721T XRCC7 associated with the risk of PE. The Gln/Gln genotype of Arg399Gln XRCC1 polymorphism increased the risk of PE (OR=2.39, 95 % CI: 1.38-4.14, P=0.002). Statistical analysis revealed that the haplotype "194Arg-399Gln" showed higher frequency among PE patients compared to the controls (OR=1.65, 95% CI: 1.23-2.19, P=0.001).
  
  
  CONCLUSIONS
  The present results suggest that the 399Gln allele of the XRCC1 is significant risk factor for PE development.
authors: Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran.
authors: Iraj
authors: I
authors: Saadat
authors: Zahra
authors: Z
authors: Beyzaei
authors: Fatemeh
authors: F
authors: Aghaei
authors: Sedighe
authors: S
authors: Kamrani
authors: Mostafa
authors: M
authors: Saadat
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D051747:DNA-Activated Protein Kinase / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D018384:Oxidative Stress / Q000235:genetics; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human