title: Is single reading with computer-aided detection (CAD) as good as double reading in mammography screening? A systematic review.
abstract: BACKGROUND
  In accordance with European guidelines, mammography screening comprises independent readings by two breast radiologists (double reading). CAD (computer-aided detection) has been suggested to complement or replace one of the two readers (single reading + CAD).The aim of this systematic review is to address the following question: Is the reading of mammographic x-ray images by a single breast radiologist together with CAD at least as accurate as double reading?
  
  
  METHODS
  The electronic literature search included the databases Pub Med, EMBASE and The Cochrane Library. Two independent reviewers assessed abstracts and full-text articles.
  
  
  RESULTS
  1049 abstracts were identified, of which 996 were excluded with reference to inclusion and exclusion criteria; 53 full-text articles were assessed for eligibility. Finally, four articles were included in the qualitative analysis, and one in a GRADE synthesis.
  
  
  CONCLUSIONS
  The scientific evidence is insufficient to determine whether the accuracy of single reading + CAD is at least equivalent to that obtained in standard practice, i.e. double reading where two breast radiologists independently read the mammographic images.
authors: Department of Diagnostic Radiology, Karolinska Institutet, Stockholm, Sweden.
authors: Edward
authors: E
authors: Azavedo
authors: Sophia
authors: S
authors: Zackrisson
authors: Ingegerd
authors: I
authors: Mejàre
authors: Marianne
authors: M
authors: Heibert Arnlind
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008327:Mammography / Q000706:statistics & numerical data*; D008403:Mass Screening / Q000706:statistics & numerical data*; D015588:Observer Variation; D010363:Pattern Recognition, Automated / Q000706:statistics & numerical data*; D015995:Prevalence; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity