title: Saracoside: a new lignan glycoside from Saraca indica, a potential inhibitor of DNA topoisomerase IB.
abstract: Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3, (+)5'-methoxyisolarciresinol-9'-O-beta-D-glucopyranoside and nudiposide, and a phenolic glucopyranoside, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, which has been isolated for the first time from this species. The isolated lignan glycosides exhibit potent DNA topoisomerase IB inhibitory activity.
authors: Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata -700032, India.
authors: Tulika
authors: T
authors: Mukherjee
authors: Sayan
authors: S
authors: Chowdhury
authors: Ashish
authors: A
authors: Kumar
authors: Hemanta K
authors: HK
authors: Majumder
authors: Parasuraman
authors: P
authors: Jaisankar
authors: Sibabrata
authors: S
authors: Mukhopadhyay
mesh_terms: D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D017705:Lignans; D059004:Topoisomerase I Inhibitors; C585909:saracoside