title: [Biomechanical modeling of pelvic organ mobility: towards personalized medicine].
abstract: Female pelvic mobility is crucial for urinary, bowel and sexual function and for vaginal delivery. This mobility is ensured by a complex organ suspension system composed of ligaments, fascia and muscles. Impaired pelvic mobility affects one in three women of all ages and can be incapacitating. Surgical management has a high failure rate, largely owing to poor knowledge of the organ support system, including the barely discernible ligamentous system. We propose a 3D digital model of the pelvic cavity based on MRI images and quantitative tools, designed to locate the pelvic ligaments. We thus obtain a coherent anatomical and functional model which can be used to analyze pelvic pathophysiology. This work represents a first step towards creating a tool for localizing and characterizing the source of pelvic imbalance. We examine possible future applications of this model, in terms of personalized therapy and prevention.
authors: Gynécologie, Hôpital Jeanne de Flandre, CHRU Lille, 59000 Lille, France. Michel.Cosson@CHRU-lille.fr
authors: Michel
authors: M
authors: Cosson
authors: Chrystèle
authors: C
authors: Rubod
authors: Alexandra
authors: A
authors: Vallet
authors: Jean-François
authors: JF
authors: Witz
authors: Mathias
authors: M
authors: Brieu
mesh_terms: D001696:Biomechanical Phenomena; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008022:Ligaments / Q000033:anatomy & histology / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D010388:Pelvis / Q000033:anatomy & histology* / Q000502:physiology*