title: Disc-electrospun cellulose acetate butyrate nanofibers show enhanced cellular growth performances.
abstract: Cellulose acetate butyrate nanofibers were prepared separately by two electrospinning techniques; a needleless electrospinning using a disc as spinneret and a rotary drum as collector and a conventional needle electrospinning using a rotary drum as collector. Compared to the needle-electrospun nanofibers, the disc-electrospun nanofibers were coarser with a wider diameter distribution. Both fibers had a similar surface morphology and they showed no difference in chemical components, but the disc-electrospun nanofibers were slightly higher in crystallinity. The productivity of disc electrospinning was 150 times larger than that of needle electrospinning. The disc-electrospun nanofiber mats were found to have a three dimensional fibrous structure with an average pore size of 9.1 μm, while the needle-electrospun nanofibers looked more like a two-dimensional sheet with a much smaller average pore size (3.2 μm). Fibroblasts and Schwann cells were cultured on the fibrous matrices to assess the biocompatibility. The disc-electrospun nanofiber webs showed enhanced cellular growth for both fibroblasts and Schwann cells, especially in a long culture period.
authors: College of Textiles, Donghua University, Shanghai 201620, China.
authors: Chen
authors: C
authors: Huang
authors: Haitao
authors: H
authors: Niu
authors: Chunchen
authors: C
authors: Wu
authors: Qinfei
authors: Q
authors: Ke
authors: Xiumei
authors: X
authors: Mo
authors: Tong
authors: T
authors: Lin
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D051381:Rats; D012583:Schwann Cells / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D014961:X-Ray Diffraction
chemical_list: D002482:Cellulose; C014396:cellulose acetate-butyrate