title: Serotype distribution of invasive  Streptococcus pneumoniae  in Canada during the introduction of the 13-valent pneumococcal conjugate vaccine, 2010.
abstract: A baseline serotype distribution was established by age and region for 2058 invasive  Streptococcus pneumoniae  isolates collected during the implementation period of the 13-valent pneumococcal conjugate vaccine (PCV13) program in many parts of Canada in 2010. Serotypes 19A, 7F, and 3 were the most prevalent in all age groups, accounting for 57% in <2 year olds, 62% in 2-4 year olds, 45% in 5-14 year olds, 44% in 15-49 year olds, 41% in 50-64 year olds, and 36% in ≥65 year olds. Serotype 19A was most predominant in Western and Central Canada representing 15% and 22%, respectively, of the isolates from those regions, whereas 7F was most common in Eastern Canada with 20% of the isolates. Other prevalent serotypes include 15A, 23B, 12F, 22F, and 6C. PCV13 serotypes represented 65% of the pneumococci isolated from <2 year olds, 71% of 2-4 year olds, 61% of 5-14 year olds, 60% of 15-49 year olds, 53% of 50-64 year olds, and 49% of the ≥65 year olds. Continued monitoring of invasive pneumococcal serotypes in Canada is important to identify epidemiological trends and assess the impact of the newly introduced PCV13 vaccine on public health.
authors: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada. walter.demczuk@phac-aspc.gc.ca
authors: Walter H B
authors: WH
authors: Demczuk
authors: Irene
authors: I
authors: Martin
authors: Averil
authors: A
authors: Griffith
authors: Brigitte
authors: B
authors: Lefebvre
authors: Allison
authors: A
authors: McGeer
authors: Amanda
authors: A
authors: Shane
authors: George G
authors: GG
authors: Zhanel
authors: Gregory J
authors: GJ
authors: Tyrrell
authors: Matthew W
authors: MW
authors: Gilmour
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification; D055815:Young Adult
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines