title: Oxysterol receptors, AKT and prostate cancer.
abstract: Oxysterols derive from cholesterol oxidation. They display various biological activities such as regulating cholesterol, fatty acid and glucose homeostasis as well as cell survival/apoptosis balance. Oxysterols display these metabolic and transcriptional activities mainly through their nuclear receptors known as Liver X Receptors (LXRs) α and β. There is accumulating evidence that LXRs are key modulators of prostate cancer cell survival. Hence, LXR activation increases cholesterol efflux and induces a disruption of lipid rafts. The decrease of membrane cholesterol causes a down regulation of AKT survival pathway and consequently apoptosis. Moreover cholesterol is associated with an increased risk of developing aggressive forms of prostate cancer. These data highlight the interest of targeting the LXR-AKT axis in prostate carcinogenesis.
authors: Clermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France.
authors: Julie
authors: J
authors: Dufour
authors: Emilie
authors: E
authors: Viennois
authors: Hugues
authors: H
authors: De Boussac
authors: Silvère
authors: S
authors: Baron
authors: Jean-Marc
authors: JM
authors: Lobaccaro
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D000071518:Liver X Receptors; D008297:Male; D021962:Membrane Microdomains / Q000378:metabolism; D057093:Orphan Nuclear Receptors / Q000378:metabolism*; D010084:Oxidation-Reduction; D011471:Prostatic Neoplasms / Q000473:pathology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D013261:Sterols / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D013261:Sterols; D002784:Cholesterol; D051057:Proto-Oncogene Proteins c-akt