title: Anti-platelet aggregation and vasorelaxing effects of the constituents of the rhizomes of Zingiber officinale.
abstract: In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6]-shogaol exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol inhibited the Ca²⁺-dependent contractions in high K⁺ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
authors: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
authors: Yu-Ren
authors: YR
authors: Liao
authors: Yann-Lii
authors: YL
authors: Leu
authors: Yu-Yi
authors: YY
authors: Chan
authors: Ping-Chung
authors: PC
authors: Kuo
authors: Tian-Shung
authors: TS
authors: Wu
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002396:Catechols / Q000737:chemistry / Q000302:isolation & purification; D005233:Fatty Alcohols; D020939:Zingiber officinale / Q000737:chemistry*; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D027343:Rhizome / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002396:Catechols; D005233:Fatty Alcohols; C576570:O-methyldehydrogingerol; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; C007845:gingerol