title: Increased voltage-dependent K+channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness.
abstract: Voltage-dependent K+channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy specimens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS.
authors: Molecular Physiology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, E-08028 Barcelona.
authors: Joanna
authors: J
authors: Bielanska
authors: Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona.
authors: Javier
authors: J
authors: Hernández-Losa
authors: Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona.
authors: Teresa
authors: T
authors: Moline
authors: Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona.
authors: Rosa
authors: R
authors: Somoza
authors: Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona.
authors: Santiago
authors: S
authors: Ramón Y Cajal
authors: Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, E-08907 Barcelona, Spain.
authors: Enric
authors: E
authors: Condom
authors: Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona.
authors: Joan Carles
authors: JC
authors: Ferreres
authors: Molecular Physiology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, E-08028 Barcelona.
authors: Antonio
authors: A
authors: Felipe