title: Cell cycle regulation of Rho signaling pathways.
abstract: The dynamics of the actin cytoskeleton and its regulation by Rho GTPases are essential to maintain cell shape, to allow cell motility and are also critical during cell cycle progression and mitosis. Rho GTPases and their effectors are involved in cell rounding at mitosis onset, in chromosomes alignment and are required for contraction of the actomyosin ring that separates daughter cells at the end of mitosis. Recent studies have revealed how a number of nucleotide exchange factors and GTPase-activating proteins regulate the activity of Rho GTPases during these processes. This review will focus on how the cell cycle machinery, in turn, regulates expression of proteins in the Rho signaling pathways through transcriptional activation, ubiquitylation and proteasomal degradation and modulates their activity through phosphorylation by mitotic kinases.
authors: Inserm U749, Institut Gustave Roussy, Villejuif, France.
authors: Muriel
authors: M
authors: David
authors: Dominique
authors: D
authors: Petit
authors: Jacques
authors: J
authors: Bertoglio
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle; D002454:Cell Differentiation; D004789:Enzyme Activation; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology / Q000201:enzymology; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism; D059748:Proteolysis; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D054875:Ubiquitination; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016203:CDC2 Protein Kinase; D046988:Proteasome Endopeptidase Complex; D020741:rho GTP-Binding Proteins