title: Regenerative therapy: a periodontal-endodontic perspective.
abstract: Periodontal and endodontic diseases are inflammatory responses leading to periodontal and pulpal tissue loss. Regenerative therapies aim to restore the lost structures to vitality and function. Various materials and treatments methods have been used such as bone grafts, guided tissue regeneration, enamel matrix derivatives, growth and differentiation factors, and stem cells. Although the current materials and methods demonstrated adequate clinical results, true and complete biological tissue regeneration is not yet attainable. The current article reviews chronologically the materials and methods used in periodontal and endodontic regeneration highlighting their clinical success and shortcomings, and discussing future directions in regenerative therapy.
authors: Periodontology Department, The Boston University Institute for Dental Research and Education, PO Box 505097, Dubai Healthcare City, Dubai, United Arab Emirates. kinaia@perio.org
authors: Bassam Michael
authors: BM
authors: Kinaia
authors: Sami M A
authors: SM
authors: Chogle
authors: Atheel M
authors: AM
authors: Kinaia
authors: Harold E
authors: HE
authors: Goodis
mesh_terms: D016025:Bone Transplantation / Q000379:methods*; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D003788:Dental Pulp Diseases / Q000503:physiopathology / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D010510:Periodontal Diseases / Q000503:physiopathology / Q000628:therapy*
chemical_list: D003746:Dental Enamel Proteins; D036341:Intercellular Signaling Peptides and Proteins; C109069:enamel matrix proteins