title: Potential of ordered mesoporous silica for oral delivery of poorly soluble drugs.
abstract: The use of ordered mesoporous silica is one of the more recent and rapidly developing formulation techniques for enhancing the solubility of poorly water-soluble drugs. Their large surface area and pore volume make ordered mesoporous silica materials excellent candidates for efficient drug loading and rapid release. While this new approach offers many promising advantages, further research is still necessary to elucidate the molecular mechanisms and to improve our scientific insight into the behavior of this system. In this review, the significant developments to date are presented and research challenges highlighted. Aspects of downstream processability are discussed in view of their special bulk powder properties and unique pore architecture. Lastly, perspectives for successful oral dosage form development are presented.
authors: Laboratory for Pharmacotechnology & Biopharmacy, Katholieke Universiteit Leuven, Leuven 3000, Belgium.
authors: Monica
authors: M
authors: Vialpando
authors: Johan A
authors: JA
authors: Martens
authors: Guy
authors: G
authors: Van den Mooter
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D012995:Solubility
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide