title: Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion.
abstract: We report the cases of 3 infants with congenital hypothyroidism detected with the use of our newborn screening program, with evidence supporting excess maternal iodine ingestion (12.5 mg/d) as the etiology. Levels of whole blood iodine extracted from their newborn screening specimens were 10 times above mean control levels. Excess iodine ingestion from nutritional supplements is often unrecognized.
authors: Department of Pediatrics, Division of Pediatric Endocrinology, Oregon Health & Science University Doernbecher Children's Hospital, Portland, OR 972389, USA. connellk@ohsu.edu
authors: Kara J
authors: KJ
authors: Connelly
authors: Bruce A
authors: BA
authors: Boston
authors: Elizabeth N
authors: EN
authors: Pearce
authors: David
authors: D
authors: Sesser
authors: David
authors: D
authors: Snyder
authors: Lewis E
authors: LE
authors: Braverman
authors: Sam
authors: S
authors: Pino
authors: Stephen H
authors: SH
authors: LaFranchi
mesh_terms: D003409:Congenital Hypothyroidism / Q000209:etiology* / Q000503:physiopathology; D019587:Dietary Supplements / Q000009:adverse effects* / Q000032:analysis; D004200:Diseases in Twins / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D015997:Neonatal Screening; D018673:Nutrition Policy; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*
chemical_list: D007455:Iodine