title: Protective effects of adenosine on the diabetic myocardium against ischemia-reperfusion injury: role of calpain.
abstract: Myocardial ischemia/reperfusion injury (I/RI) is the principal cause of mortality and morbidity in diabetic patients undergoing cardiac surgery. However, there is no specific measure available to protect diabetic hearts in this clinical setting. Our clinical studies showed that adenosine pre-treatment or post-treatment and adding adenosine to cardioplegia solution had significant myocardial protective effects in patients undergoing cardiac surgery. However, the specific protective effects and mechanisms of adenosine in diabetic myocardial I/RI are not clear. Calpain is an important proteolytic enzyme in the myocardium. Studies show that the activation of calpain is an injury factor in not only the diabetic myocardium but also myocardial I/RI progression. We therefore hypothesize that adenosine play a protective role in diabetic myocardial I/RI through the inhibition of calpain.
authors: Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127# Changle West Road, Xi'an 710032, China.
authors: Yang
authors: Y
authors: Yang
authors: Weixun
authors: W
authors: Duan
authors: Jingjun
authors: J
authors: Zhou
authors: Juanjuan
authors: J
authors: Yan
authors: Jincheng
authors: J
authors: Liu
authors: Jianying
authors: J
authors: Zhang
authors: Zhenxiao
authors: Z
authors: Jin
authors: Dinghua
authors: D
authors: Yi
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002154:Calpain / Q000037:antagonists & inhibitors*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D048909:Diabetes Complications / Q000201:enzymology / Q000517:prevention & control*; D006324:Heart Arrest, Induced; D006801:Humans; D008955:Models, Cardiovascular; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000201:enzymology / Q000517:prevention & control*; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D011480:Protease Inhibitors; D002154:Calpain; D000241:Adenosine