title: Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention.
abstract: OBJECTIVE
  To investigate the relationship between renal function and clinical outcomes among patients with acute ST-segment elevation myocardial infarction (ASTEMI), who were treated with emergency percutaneous coronary intervention (PCI).
  
  
  METHODS
  420 patients hospitalized in Peking University First Hospital, diagnosed with ASTEMI treated with emergency (PCI) from January 2001 to June 2011 were enrolled in this study. Estimated glomerular filtration rate (eGFR) was used as a measure of renal function. We compared the clinical parameters and outcomes between ASTEMI patients combined renal insufficiency and the patients with normal renal function.
  
  
  RESULTS
  There was a significant increase in the concentrations of fibrinogen and D-Dimer (P<0.05) and a much higher morbidity of diabetes mellitus in the group of patients with chronic kidney disease (CKD; eGFR<60 ml/(min·1.73 m(2))) (P<0.01). CKD (eGFR<60 ml/(min·1.73 m(2))) was an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI receiving PCI therapy rapidly (P=0.032, odds ratio (OR) 4.159, 95% confidence interval (CI) 1.127-15.346).
  
  
  CONCLUSIONS
  Renal insufficiency is an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI treated with primary PCI.
authors: Department of Cardiology, Peking University First Hospital, Peking University, Beijing 100043, China.
authors: Jian-ping
authors: JP
authors: Li
authors: Mohetaboer
authors: M
authors: Momin
authors: Yong
authors: Y
authors: Huo
authors: Chun-yan
authors: CY
authors: Wang
authors: Yan
authors: Y
authors: Zhang
authors: Yan-jun
authors: YJ
authors: Gong
authors: Zhao-ping
authors: ZP
authors: Liu
authors: Xin-gang
authors: XG
authors: Wang
authors: Bo
authors: B
authors: Zheng
mesh_terms: D000368:Aged; D019281:Dimerization; D004562:Electrocardiography / Q000379:methods; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry; D005919:Glomerular Filtration Rate; D006760:Hospitalization; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D062645:Percutaneous Coronary Intervention / Q000379:methods; D051437:Renal Insufficiency / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen