title: Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection.
abstract: Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is a recently described disease entity, characterized by nonorganized electron-dense deposits in glomeruli and immunofluorescence findings indicating monoclonal immunoglobulin G deposits. The pathogenesis of many cases of proliferative glomerulonephritis with monoclonal immunoglobulin G deposits remains unknown. We herein report 2 patients with parvovirus B19 infection who developed acute nephritic syndrome with hypocomplementemia (patient 1) or persistent proteinuria and congestive heart failure (patient 2); however, neither patient had detectable levels of serum monoclonal immunoglobulin G. Renal biopsy in both patients showed diffuse endocapillary proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits, and electron microscopy showed nonorganized electron-dense deposits mainly in the subendothelial and mesangial areas. Clinical symptoms, abnormal laboratory findings, and urinary abnormalities recovered spontaneously in both cases within 4 weeks. Our 2 cases may be the first reported patients with proliferative glomerulonephritis with monoclonal immunoglobulin G deposits possibly associated with parvovirus B19 infection. Virus infection-associated immune disorders could be implicated in the pathogenesis of proliferative glomerulonephritis with monoclonal immunoglobulin G deposits.
authors: Department of Internal Medicine (Division of Neurology, Nephrology, and Rheumatology), Nippon Medical School, Tokyo 113-8602, Japan.
authors: Emiko
authors: E
authors: Fujita
authors: Akira
authors: A
authors: Shimizu
authors: Tomohiro
authors: T
authors: Kaneko
authors: Yukinari
authors: Y
authors: Masuda
authors: Chikara
authors: C
authors: Ishihara
authors: Akiko
authors: A
authors: Mii
authors: Seiichiro
authors: S
authors: Higo
authors: Yusuke
authors: Y
authors: Kajimoto
authors: Go
authors: G
authors: Kanzaki
authors: Shinya
authors: S
authors: Nagasaka
authors: Yasuhiko
authors: Y
authors: Iino
authors: Yasuo
authors: Y
authors: Katayama
authors: Yuh
authors: Y
authors: Fukuda
mesh_terms: D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000276:immunology; D010322:Parvoviridae Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G