title: [Psychiatric implications of PACAP signaling pathway].
abstract: Studies on genetically modified mice for investigating the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the brain have revealed a previously uncharacterized function of this neuropeptidergic signaling in the regulation of psychomotor behaviors. In addition, recent clinical studies investigating single nucleotide polymorphisms and copy number variations in the PACAP and its receptor genes have associated the variations with major psychiatric disorders and stress-dependent mental disorders. Here, I briefly review these recent advances in the field and make this an opportunity to consider future direction of research.
authors: Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Japan. hasimoto@phs.osaka-u.ac.jp
authors: Hitoshi
authors: H
authors: Hashimoto
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000172:deficiency / Q000378:metabolism*; D011597:Psychomotor Performance / Q000502:physiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide