title: Hepatocyte growth factor in saliva of patients with renal failure and periodontal disease.
abstract: BACKGROUND
  Hepatocyte growth factor (HGF), endogenous cytokine with pleiotropic repairing and regeneration properties in relation to most tissues and organs, contributes to the progression of periodontal disease (PD). Furthermore, PD is a significant health problem in patients with chronic renal failure (CRF). The role of HGF in the development of PD in this specific population was not a subject of research so far.
  
  
  METHODS
  The following groups were enrolled in the study: (1) 26 chronic hemodialysis (HD) subjects, (2) 26 patients treated by continuous ambulatory peritoneal dialysis (CAPD), (3) 28 predialysis CRF patients, (4) 26 subjects with advanced PD (without coexisting diseases), and (5) 20 healthy subjects without PDs. HGF level in saliva was measured using the immunoenzymatic method. Gingival index, papillary bleeding index, plaque index, and the loss of clinical attachment level were evaluated.
  
  
  RESULTS
  The HGF level in saliva of HD patients was twice higher than in that of subjects with healthy periodontium. Direct relationships between proper HGF level in saliva and the indices GI, PBI, and PI in CAPD-treated patients and with more severe PD were shown. It was found that PD is most advanced in HD patients, moderately in CAPD-treated patients and to the smallest extent in predialysis CRF patients.
  
  
  CONCLUSIONS
  The HGF level in mixed saliva is the index of PD progression in subjects without renal failure and in CAPD-treated patients. PD is common in renal failure patients and is a significant problem concerning general health status.
authors: Department of Conservative Dentistry, Medical University of Bialystok, Białystok, Poland. magdalena.borawska@e.pl
authors: Magdalena
authors: M
authors: Wilczyńska-Borawska
authors: Jacek
authors: J
authors: Borawski
authors: Joanna
authors: J
authors: Bagińska
authors: Jolanta
authors: J
authors: Małyszko
authors: Michał
authors: M
authors: Myśliwiec
mesh_terms: D000328:Adult; D005260:Female; D017228:Hepatocyte Growth Factor / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications / Q000473:pathology*; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000150:complications / Q000473:pathology* / Q000628:therapy; D012463:Saliva / Q000737:chemistry*
chemical_list: D017228:Hepatocyte Growth Factor