title: BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis.
abstract: Melioidosis is a disease caused by infection with Burkholderia pseudomallei. The molecular basis for the pathogenicity of B. pseudomallei is poorly understood. However, recent work has identified the first toxin from this bacterium and shown that it inhibits host protein synthesis. Here, we review the illness that is potentially associated with biological warfare, the pathogen and its deadly molecular mechanism of action, as well as therapeutic developments that may follow.
authors: Department of Molecular Biology and Biotechnology, University Of Sheffield, Western Bank, Sheffield, UK. G.Hautbergue@sheffield.ac.uk
authors: Guillaume M
authors: GM
authors: Hautbergue
authors: Stuart A
authors: SA
authors: Wilson
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism*; D016957:Burkholderia pseudomallei / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D008554:Melioidosis / Q000378:metabolism*; D014176:Protein Biosynthesis
chemical_list: C572779:BLF1 toxin, Burkholderia pseudomallei; D001427:Bacterial Toxins