title: Radioembolisation with (90)Y-labelled resin microspheres in the treatment of liver metastasis from breast cancer.
abstract: OBJECTIVE
  Metastatic breast cancer is a heterogeneous disease, commonly affecting the liver. We report our experience with (90)Y radioembolisation (RE) and its effects on the survival of patients with treatment-refractory breast cancer liver metastases.
  
  
  METHODS
  A total of 77 female patients affected by breast cancer were accepted into our department for RE. Inclusion criteria were inoperable and chemotherapy-refractory hepatic metastases, acceptable performance status, sufficient residual liver, no significant hepato-pulmonary shunts. Patients were divided in two groups: group 1 (29 patients) included those with Eastern Cooperative Oncology Group (ECOG) score 0, liver involvement (0-25 %) and no extrahepatic disease (EHD); group 2 (23 patient) included patients with ECOG score 1-2, liver involvement (26-50 %) and evidence of EHD.
  
  
  RESULTS
  A total of 25 patients were considered ineligible. The median age of the remaining 52 patients was 57.5 years. The median overall survival was 11.5 months and better in those whose performance status and liver function were preserved (14.3 versus 8.2 months). According to Response Evaluation Criteria in Solid Tumor (RECIST), partial response (PR) was achieved in 29 patients (56 %), stable disease (SD) was achieved in a further 18 patients (35 %) and 5 patients showed progressive disease (PD) (10 %).
  
  
  CONCLUSIONS
  (90)Y RE is effective in the treatment of liver metastases from breast cancer. We demonstrated a relevant survival and encouragingly high response rate in patients with treatment-refractory disease.
authors: Department of Diagnostic and Interventional Radiology, Santa Maria Goretti Hospital, Via Guido Reni n. 1, 04100, Latina, Italy.
authors: R
authors: R
authors: Cianni
authors: G
authors: G
authors: Pelle
authors: E
authors: E
authors: Notarianni
authors: A
authors: A
authors: Saltarelli
authors: P
authors: P
authors: Rabuffi
authors: O
authors: O
authors: Bagni
authors: L
authors: L
authors: Filippi
authors: E
authors: E
authors: Cortesi
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008863:Microspheres; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes