title: Synthesis and cytotoxicity testing of new amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives.
abstract: A series of amido-substituted triazolopyrrolo[2,1-c][1,4]benzodiazepine (PBDT) derivatives was synthesized from isatoic anhydride, and their cytotoxicity against the MRC-5 and Mahlavu cell lines was evaluated. The results suggest that compound PBDT-7i with the meta-trifluoromethylbenzoyl substituent can selectively inhibit the growth of Mahlavu cells and has low toxicity towards MRC-5 cells.
authors: Medicinal Chemistry Laboratory, GVK Biosciences Private Limited, Plot No. 5C, IDA Uppal, Hyderabad 500039, AP, India.
authors: Kumaraswamy
authors: K
authors: Sorra
authors: Chi-Fen
authors: CF
authors: Chang
authors: Srinivas
authors: S
authors: Pusuluri
authors: Khagga
authors: K
authors: Mukkanti
authors: Min-Chiau
authors: MC
authors: Laiu
authors: Bo-Ying
authors: BY
authors: Bao
authors: Chia-Hao
authors: CH
authors: Su
authors: Ta-Hsien
authors: TH
authors: Chuang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012844:Sincalide / Q000378:metabolism; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles; D014230:Triazoles; D001569:Benzodiazepines; D012844:Sincalide