title: Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis.
abstract: The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and β-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus.
authors: Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors: V A
authors: VA
authors: Chereshnev
authors: L V
authors: LV
authors: Gankovskaya
authors: L V
authors: LV
authors: Koval'chuk
authors: M V
authors: MV
authors: Chereshneva
authors: O A
authors: OA
authors: Gankovskaya
authors: T V
authors: TV
authors: Gavrilova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003315:Cornea / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D015870:Gene Expression; D006561:Herpes Simplex; D007113:Immunity, Innate; D016849:Keratitis, Herpetic / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051217:Toll-Like Receptor 9 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D023083:beta-Defensins / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; C495370:Tlr9 protein, mouse; D051217:Toll-Like Receptor 9; D023083:beta-Defensins