title: Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes.
abstract: Foregoing researches made on the N/OFQ system brought up a possible role for this system in cardiovascular regulation. In this study we examined how N/OFQ levels of the blood plasma changed in acute cardiovascular diseases. Three cardiac patient groups were created: enzyme positive acute coronary syndrome (EPACS, n = 10), enzyme negative ACS (ENACS, n = 7) and ischemic heart disease (IHD, n = 11). We compared the patients to healthy control subjects (n = 31). We found significantly lower N/OFQ levels in the EPACS [6.86 (6.21-7.38) pg/ml], ENACS [6.97 (6.87-7.01) pg/ml and IHD groups [7.58 (7.23-8.20) pg/ml] compared to the control group [8.86 (7.27-9.83) pg/ml]. A significant correlation was detected between N/OFQ and white blood cell count (WBC), platelet count (PLT), creatine kinase (CK), glutamate oxaloacetate transaminase (GOT) and cholesterol levels in the EPACS group.Decreased plasma N/OFQ is closely associated with the presence of acute cardiovascular disease, and the severity of symptoms has a significant negative correlation with the N/OFQ levels. We believe that the rate of N/OFQ depression is in association with the level of ischemic stress and the following inflammatory response. Further investigations are needed to clarify the relevance and elucidate the exact effects of the ischemic stress on the N/OFQ system.
authors: Semmelweis University Heart Center, Budapest, Hungary.
authors: Cs
authors: C
authors: Csobay-Novák
authors: P
authors: P
authors: Sótonyi
authors: M
authors: M
authors: Krepuska
authors: E
authors: E
authors: Zima
authors: N
authors: N
authors: Szilágyi
authors: Sz
authors: S
authors: Tóth
authors: Z
authors: Z
authors: Szeberin
authors: Gy
authors: G
authors: Acsády
authors: B
authors: B
authors: Merkely
authors: Kornélia
authors: K
authors: Tekes
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006814:Hungary; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D018847:Opioid Peptides / Q000097:blood*; D010976:Platelet Count; D012720:Severity of Illness Index; D000097629:Nociceptin
chemical_list: D001219:Aspartate Aminotransferases; D015415:Biomarkers; D002784:Cholesterol; D003402:Creatine Kinase; D018847:Opioid Peptides; D000097629:Nociceptin