title: Mechanisms of disease progression in NASH: new paradigms.
abstract: The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and NASH progression shows that hedgehog (Hh) is reactivated after liver injury to assist in liver repair and regeneration. When the process of tissue repair and regeneration is prolonged or when Hh ligand and related genes are aberrantly regulated and excessive, tissue repair goes awry and NASH progresses to cirrhosis and hepatocellular carcinoma.
authors: Department of Endocrinology, Diabetes and Metabolism, Duke University Hospital, Durham, NC 27710, USA.
authors: Brittany N
authors: BN
authors: Bohinc
authors: Anna Mae
authors: AM
authors: Diehl
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D019898:Autocrine Communication / Q000502:physiology; D018450:Disease Progression; D005109:Extracellular Matrix / Q000502:physiology; D005234:Fatty Liver / Q000503:physiopathology*; D053823:Hedgehog Proteins / Q000502:physiology; D055166:Hepatic Stellate Cells / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000293:injuries; D008103:Liver Cirrhosis / Q000503:physiopathology; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease; D019899:Paracrine Communication / Q000502:physiology; D051381:Rats; D012307:Risk Factors
chemical_list: D053823:Hedgehog Proteins