title: [Severe meprobamate poisoning: description of 146 cases in a French             department].
abstract: Meprobamate poisoning are serious and sometimes fatal. Faced with a potential stop of marketing, we conducted a multicenter retrospective study to assess the severity criteria presented by patients admitted to the ICU for severe meprobamate poisoning, whether with alone form or in combination with aceprometazine. One hundred fourty-six patients have been enrolled between January 2005 and June 2011: 38 had a single meprobamate poisoning, 104 to meprobamate and aceprometazine and 4 to both forms. At admission, 88% of patients exhibited coma (Glasgow ≤ 7) and half of them a systolic blood pressure ≤ 90 mmHg. Mortality rate was 3%. Our results did not find any significant between-group difference, either in regard of clinical or biological severity criteria. These data argue for a cessation of marketing of all meprobamate-based specialities.
authors: Urgences Médico-chirurgicales, Hôpital Nord, CHU, Saint-Étienne, France.
authors: Bérenger
authors: B
authors: Mounier
authors: Bertrand
authors: B
authors: Pons
authors: Xavier
authors: X
authors: Delavenne
authors: Marie-Noëlle
authors: MN
authors: Beyens
authors: Cécile
authors: C
authors: Rémy
authors: Fabrice
authors: F
authors: Zeni
authors: Patrick
authors: P
authors: Mismetti
authors: Thierry
authors: T
authors: Basset
mesh_terms: D000075:Acepromazine / Q000031:analogs & derivatives / Q000506:poisoning; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003128:Coma / Q000139:chemically induced / Q000628:therapy; D056736:Drug Recalls; D005260:Female; D005602:France / Q000453:epidemiology; D015600:Glasgow Coma Scale; D006760:Hospitalization; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D008297:Male; D008620:Meprobamate / Q000506:poisoning*; D008875:Middle Aged; D011041:Poisoning / Q000401:mortality; D012189:Retrospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D000075:Acepromazine; C021280:aceprometazine; D008620:Meprobamate