title: Immunosignaturing can detect products from molecular markers in brain cancer.
abstract: Immunosignaturing shows promise as a general approach to diagnosis. It has been shown to detect immunological signs of infection early during the course of disease and to distinguish Alzheimer's disease from healthy controls. Here we test whether immunosignatures correspond to clinical classifications of disease using samples from people with brain tumors. Blood samples from patients undergoing craniotomies for therapeutically naïve brain tumors with diagnoses of astrocytoma (23 samples), Glioblastoma multiforme (22 samples), mixed oligodendroglioma/astrocytoma (16 samples), oligodendroglioma (18 samples), and 34 otherwise healthy controls were tested by immunosignature. Because samples were taken prior to adjuvant therapy, they are unlikely to be perturbed by non-cancer related affects. The immunosignaturing platform distinguished not only brain cancer from controls, but also pathologically important features about the tumor including type, grade, and the presence or absence of O(6)-methyl-guanine-DNA methyltransferase methylation promoter (MGMT), an important biomarker that predicts response to temozolomide in Glioblastoma multiformae patients.
authors: Biodesign Institute, Center for Innovations in Medicine, Arizona State University, Tempe, Arizona, United States of America.
authors: Alexa K
authors: AK
authors: Hughes
authors: Zbigniew
authors: Z
authors: Cichacz
authors: Adrienne
authors: A
authors: Scheck
authors: Stephen W
authors: SW
authors: Coons
authors: Stephen Albert
authors: SA
authors: Johnston
authors: Phillip
authors: P
authors: Stafford
mesh_terms: D000328:Adult; D000912:Antibodies, Neoplasm / Q000097:blood* / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D016022:Case-Control Studies; D019295:Computational Biology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D040081:Protein Array Analysis
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor