title: Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles.
abstract: Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
authors: Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg, Germany. jan.streuff@ocbc.uni-freiburg.de
authors: Jan
authors: J
authors: Streuff
authors: Markus
authors: M
authors: Feurer
authors: Plamen
authors: P
authors: Bichovski
authors: Georg
authors: G
authors: Frey
authors: Urs
authors: U
authors: Gellrich
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D007659:Ketones; D009570:Nitriles; D014025:Titanium