title: Opuntia humifusa supplementation increased bone density by regulating parathyroid hormone and osteocalcin in male growing rats.
abstract: We investigated the effect of Opuntia humifusa (O. humifusa) supplementation on bone density and related hormone secretion in growing male rats. Sixteen six-week-old male Sprague-Dawley rats were randomly divided into two groups; control diet group (CG, n = 8), and experimental diet group (EG, n = 8). The rats in the CG were given a control diet and those in the EG were given 5% O. humifusa added to the control diet for eight weeks. The serum OC level of the EG was significantly higher than that of the CG, and the serum parathyroid hormone (PTH) level of EG was significantly lower than that of the CG. In addition, the femoral and tibial BMD of the EG were significantly higher values than those of the CG, and the tibial BMC of the EG was significantly higher than that of the CG. These results suggest that O. humifusa supplementation has a positive effect on bone density by suppressing PTH and increasing the OC level in growing male rats.
authors: Laboratory of Sports Nutrition, Sunmoon University, Asan, 336-708, Republic of Korea.
authors: Junyong
authors: J
authors: Kang
authors: Laboratory of Sports Nutrition, Sunmoon University, Asan, 336-708, Republic of Korea.
authors: Jinho
authors: J
authors: Park
authors: Department of Food Science, Sunmoon University, Asan, 336-708, Republic of Korea.
authors: Seong Hee
authors: SH
authors: Choi
authors: Department of Healthcare, Nippon Sport Science University, Yokohama, 227-0033, Japan.
authors: Shoji
authors: S
authors: Igawa
authors: Laboratory of Sports Nutrition, Sunmoon University, Asan, 336-708, Republic of Korea.
authors: Youngju
authors: Y
authors: Song
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D019587:Dietary Supplements; D005269:Femur / Q000473:pathology; D008297:Male; D029747:Opuntia / Q000737:chemistry*; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000473:pathology
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D000469:Alkaline Phosphatase