title: Breast MALT lymphomas: a clinicopathological and cytogenetic study of 9 cases.
abstract: Primary breast mucosa-associated lymphoid tissue (MALT) lymphomas are uncommon             and restricted diagnostic criteria should be used to exclude breast involvement             by systemic lymphomas. The molecular pathogenesis of primary breast MALT lymphomas             is not clear because of the rarity of the disease. Generally the molecular studies             of MALT lymphoma in extranodal sites have shown the presence of different chromosomal             aberrations, mutually exclusive with substantial differences in their frequency             relatively to topographic localization. Few cases of breast MALT lymphomas in             the literature have been assessed for MALT lymphoma-associated translocations             and BCL10 expression, underlying their rarity in primary breast MALT lymphomas.             In our study, we analyzed a series of nine cases of primary breast MALT lymphomas.             FISH results showed evidence of MALT1 gene rearrangements in four primary breast             lymphomas, in particular three cases with t(11;18)(q21;q21) and one case with             t(14;18)(q32;q21). In addition, BCL10 gene rearrangement was not observed. There             was no evidence of BCL10 gene translocation in any of the neoplasms assessed.             Our data indicate that MALT1 gene rearrangements are not rare in primary breast             MALT lymphoma in contrast with results of previous series. Finally, t(11;18) has             been observed to be significantly associated with high intensity cytoplasmic BCL10             expression underlying cross-talk between MALT1 and BCL10 pathways in the pathogenesis             of MALT lymphomas.
authors: Pathology Unit, National Cancer Institute, Pascale Foundation,                     Naples, Italy.
authors: Giuseppina
authors: G
authors: Liguori
authors: Monica
authors: M
authors: Cantile
authors: Margherita
authors: M
authors: Cerrone
authors: Elvira
authors: E
authors: La Mantia
authors: Maurizio
authors: M
authors: Di Bonito
authors: Fabrizio
authors: F
authors: Zanconati
authors: Maria Pia
authors: MP
authors: Curcio
authors: Gabriella
authors: G
authors: Aquino
authors: Anna
authors: A
authors: La Mura
authors: Rosa
authors: R
authors: Giannatiempo
authors: Annarosaria
authors: A
authors: De Chiara
authors: Angela
authors: A
authors: Lombardi
authors: Gerardo
authors: G
authors: Botti
authors: Antonio
authors: A
authors: D'Antonio
authors: Michele
authors: M
authors: Caraglia
authors: Renato
authors: R
authors: Franco
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000074018:B-Cell CLL-Lymphoma 10 Protein; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D020169:Caspases / Q000235:genetics; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D009363:Neoplasm Proteins; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein