title: Hsp90 modulation for the treatment of Alzheimer's disease.
abstract: Hsp90 serves as the master regulator of the prosurvival, heat shock response. Upon exposure to cellular stress or small molecule inhibitors of Hsp90, various heat shock proteins are induced to assist in the rematuration of misfolded proteins. Several neurodegenerative diseases, including Alzheimer's disease, manifest through the accumulation of misfolded proteins, suggesting that induction of the heat shock response may provide a viable approach toward the management of such diseases. In this chapter, the rationale for such an approach and potential therapeutics are discussed.
authors: Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS, USA.
authors: Huiping
authors: H
authors: Zhao
authors: Mary L
authors: ML
authors: Michaelis
authors: Brian S J
authors: BS
authors: Blagg
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects
chemical_list: D018841:HSP90 Heat-Shock Proteins; D059808:Polyphenols