title: Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies.
abstract: OBJECTIVE
  To determine the association between the focal atrophy measures on antemortem MRI and postmortem neuropathologic classification of dementia with Lewy bodies (DLB) using the Third Report of the DLB Consortium criteria.
  
  
  METHODS
  We retrospectively identified 56 subjects who underwent antemortem MRI and had Lewy body (LB) pathology at autopsy. Subjects were pathologically classified as high (n = 25), intermediate (n = 22), and low likelihood DLB (n = 9) according to the Third Report of the DLB Consortium criteria. We included 2 additional pathologic comparison groups without LBs: one with low likelihood Alzheimer disease (AD) (control; n = 27) and one with high likelihood AD (n = 33). The associations between MRI-based volumetric measurements and the pathologic classification of DLB were tested with analysis of covariance by adjusting for age, sex, and MRI-to-death interval.
  
  
  RESULTS
  Antemortem hippocampal and amygdalar volumes increased from low to intermediate to high likelihood DLB (p < 0.001, trend test). Smaller hippocampal and amygdalar volumes were associated with higher Braak neurofibrillary tangle stage (p < 0.001). Antemortem dorsal mesopontine gray matter (GM) atrophy was found in those with high likelihood DLB compared with normal control subjects (p = 0.004) and those with AD (p = 0.01). Dorsal mesopontine GM volume decreased from low to intermediate to high likelihood DLB (p = 0.01, trend test).
  
  
  CONCLUSIONS
  Antemortem hippocampal and amygdalar volumes increase and dorsal mesopontine GM volumes decrease in patients with low to high likelihood DLB according to the Third Report of the DLB Consortium criteria. Patients with high likelihood DLB typically have normal hippocampal volumes but have atrophy in the dorsal mesopontine GM nuclei.
authors: Departments of Radiology, Mayo Clinic,Rochester, MN, USA. kantarci.kejal@mayo.edu
authors: Kejal
authors: K
authors: Kantarci
authors: Tanis J
authors: TJ
authors: Ferman
authors: Bradley F
authors: BF
authors: Boeve
authors: Stephen D
authors: SD
authors: Weigand
authors: Scott
authors: S
authors: Przybelski
authors: Prashanthi
authors: P
authors: Vemuri
authors: Melissa E
authors: ME
authors: Murray
authors: Melissa M
authors: MM
authors: Murray
authors: Matthew L
authors: ML
authors: Senjem
authors: Glenn E
authors: GE
authors: Smith
authors: David S
authors: DS
authors: Knopman
authors: Ronald C
authors: RC
authors: Petersen
authors: Clifford R
authors: CR
authors: Jack
authors: Joseph E
authors: JE
authors: Parisi
authors: Dennis W
authors: DW
authors: Dickson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000145:classification* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male