title: Is contrast-enhanced cardiac magnetic resonance imaging at 3 T superior to 1.5 T for detection of coronary artery disease?
abstract: The aim is to compare a compiled clinical routine cardiac magnetic resonance (CMR) imaging protocol performed at both 1.5 and 3 T in patients with suspected coronary artery disease (CAD) undergoing coronary X-ray angiography. CMR including adenosine perfusion and late gadolinium enhancement (LGE) at 1.5 T has been established for noninvasive detection of relevant CAD. However, little is known about the potential advantages of 3 T to detect CAD. Fifty-two evaluable patients (62.3 ± 10.2 years) were included into the study. All patients were scanned at both 1.5 and 3 T including adenosine stress and rest perfusion, and LGE imaging. CMR images were analyzed by two blinded readers in consensus. X-Ray angiography served as the reference method. A significant CAD was diagnosed by quantitative coronary analysis. Diagnostic accuracy of the combined analysis of perfusion and LGE imaging yielded better values at 1.5 and 3 T than the analysis of perfusion images alone. Specificity and sensitivity at 3 T was superior to 1.5 T in detecting coronary stenoses ≥50 % (90 vs. 75 % and 84.4 vs. 75 %) and ≥70 % (88 vs. 80 % and 96.3 vs. 88.9 %). This study showed that CMR at 3 T in a routine clinical setting is superior to 1.5 T in detection of significant CAD. 3 T might become the preferred CMR field strength for evaluation of CAD in clinical practice.
authors: Department of Internal Medicine II, University of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
authors: Thomas
authors: T
authors: Walcher
authors: Katharina
authors: K
authors: Ikuye
authors: Wolfgang
authors: W
authors: Rottbauer
authors: Jochen
authors: J
authors: Wöhrle
authors: Peter
authors: P
authors: Bernhardt
mesh_terms: D000241:Adenosine; D000368:Aged; D003287:Contrast Media; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014665:Vasodilator Agents
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D014665:Vasodilator Agents; D008536:Meglumine; D000241:Adenosine; C072417:gadoterate meglumine