title: Imputing at-work productivity loss using results of a randomized controlled trial comparing tapentadol extended release and oxycodone controlled release for osteoarthritis pain.
abstract: OBJECTIVE
  : To determine the impact of tapentadol extended release (ER) versus placebo or oxycodone controlled release (CR) on the work productivity of adults with chronic moderate to severe knee osteoarthritis pain.
  
  
  METHODS
  : Using clinical trial data on pain outcomes, a validated methodology imputed treatment group differences in at-work productivity and associated differences in productivity costs (assuming a $100,000 annual salary per participant).
  
  
  RESULTS
  : Imputed improvements in at-work productivity were significantly greater for tapentadol ER compared with either placebo (mean, 1.96% vs 1.51%; P = 0.001) or oxycodone CR (mean, 1.96% vs 1.40%; P < 0.001). Mean net savings per participant were $450 (P < 0.01) for tapentadol ER versus placebo and $560 (P = 0.001) for tapentadol ER versus oxycodone CR.
  
  
  CONCLUSIONS
  : Effective osteoarthritis pain treatment also may help employees to function better at work and reduce their employers' productivity costs.
authors: From the Program on Health, Work and Productivity (Drs Lerner, Chang, and Rogers), Institute for Clinical Research and Health Policy Studies (Drs Lerner, Chang, and Rogers), Tufts Medical Center, Tufts University School of Medicine, Boston, MA; Sackler Graduate School of Biomedical Sciences (Drs Lerner, Chang, and Rogers), Boston, MA; and Janssen Scientific Affairs, LLC (Mr Benson and Drs Chow, Kim, and Biondi).
authors: Debra
authors: D
authors: Lerner
authors: Hong
authors: H
authors: Chang
authors: William H
authors: WH
authors: Rogers
authors: Carmela
authors: C
authors: Benson
authors: Wing
authors: W
authors: Chow
authors: Myoung S
authors: MS
authors: Kim
authors: David
authors: D
authors: Biondi
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics / Q000191:economics / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy* / Q000191:economics; D003692:Delayed-Action Preparations / Q000191:economics / Q000627:therapeutic use; D004526:Efficiency / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D010098:Oxycodone / Q000191:economics / Q000627:therapeutic use*; D010636:Phenols / Q000191:economics / Q000627:therapeutic use*; D012720:Severity of Illness Index; D000077432:Tapentadol
chemical_list: D000700:Analgesics; D003692:Delayed-Action Preparations; D010636:Phenols; D010098:Oxycodone; D000077432:Tapentadol