title: Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy.
abstract: We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems.
authors: Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
authors: S S
authors: SS
authors: Almeida
authors: M G
authors: MG
authors: Naffah-Mazzacoratti
authors: P B
authors: PB
authors: Guimarães
authors: F
authors: F
authors: Wasinski
authors: F E G
authors: FE
authors: Pereira
authors: M
authors: M
authors: Canzian
authors: R S
authors: RS
authors: Centeno
authors: H
authors: H
authors: Carrete
authors: E M
authors: EM
authors: Yacubian
authors: A K
authors: AK
authors: Carmona
authors: R F F
authors: RF
authors: Vieira
authors: C R
authors: CR
authors: Nakaie
authors: R A
authors: RA
authors: Sabatini
authors: S R
authors: SR
authors: Perosa
authors: R F P
authors: RF
authors: Bacurau
authors: T L F
authors: TL
authors: Gouveia
authors: G
authors: G
authors: Gallo
authors: M
authors: M
authors: Würtele
authors: E A
authors: EA
authors: Cavalheiro
authors: J A
authors: JA
authors: Silva
authors: J B
authors: JB
authors: Pesquero
authors: R C
authors: RC
authors: Araujo
mesh_terms: D000483:Alleles; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004833:Epilepsy, Temporal Lobe / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics; D013702:Temporal Lobe / Q000187:drug effects / Q000473:pathology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000927:Anticonvulsants; D002220:Carbamazepine; D007703:Peptidyl-Dipeptidase A