title: Metallothionein 2A genetic polymorphisms and risk of prostate cancer in a Polish population.
abstract: Metallothionein 2A (MT2A) is the most expressed metallothionein (MT) isoform in prostate cells. A number of studies have demonstrated altered MT2A expression in various human tumors, including prostate cancer. We conducted an association study to examine whether MT2A gene polymorphisms are associated with a risk of prostate cancer. Genotyping was conducted using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Three single nucleotide polymorphisms (SNPs), rs28366003, rs1610216, and rs10636, were genotyped in 358 prostate cancer cases and 406 population controls. One SNP in MT2A (rs28366003) showed a positive association with prostate cancer. Compared to homozygous common allele carriers, heterozygosity for the G variant (odds ratio (OR)=2.30, 95% confidence interval (CI): 1.50-3.47, P-trend<0.0001; the OR assuming a dominant model 2.43 (95% CI: 1.62-3.61, P(dominant)=0.001) after adjustment for age) had a significantly increased risk of prostate cancer in a Polish population. Our data suggest that the rs28366003 SNP in MT2A is associated with the risk of prostate cancer in a Polish population.
authors: Department of Cytobiochemistry, University of Łódź, Łódź, Poland.
authors: Ewa
authors: E
authors: Forma
authors: Anna
authors: A
authors: Krzeslak
authors: Jacek
authors: J
authors: Wilkosz
authors: Pawel
authors: P
authors: Jozwiak
authors: Agnieszka
authors: A
authors: Szymczyk
authors: Waldemar
authors: W
authors: Rozanski
authors: Magdalena
authors: M
authors: Brys
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008668:Metallothionein / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D044465:White People
chemical_list: C491053:MT2A protein, human; D008668:Metallothionein; D017430:Prostate-Specific Antigen