title: Well-differentiated hepatocellular carcinoma in a ring-tailed lemur (Lemur catta).
abstract: A 16-year-old male ring-tailed lemur (Lemur catta) was presented with severe cachexia and an abdominal mass. The encapsulated, multilobular mass replaced the right medial lobe of the liver and compressed the adjacent gall bladder. Multiple haemorrhages and necrotic foci were found within the mass. Microscopically, neoplastic cells formed cords of moderately pleomorphic, polygonal cells with mild to moderate anaplasia. Immunohistochemical markers used for diagnosis of hepatocellular carcinomas in man were used to characterize the neoplastic cells, which expressed hepatocyte-specific antigen, but not glypican-3 or polyclonal carcinoembryonic antigen. Gross, microscopical and immunohistochemical features of the tumour were most consistent with a well-differentiated hepatocellular carcinoma. Although this tumour is common among prosimians, to the authors' knowledge this is the first documented case in a ring-tailed lemur. Hepatocellular carcinomas have been associated with hepatitis virus infections and excessive hepatic iron in man; however, no association was established between this tumour and viral infection or hepatic iron storage disease in the present case.
authors: Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA.
authors: N M
authors: NM
authors: Nemeth
authors: U
authors: U
authors: Blas-Machado
authors: P
authors: P
authors: Cazzini
authors: J
authors: J
authors: Oguni
authors: M S
authors: MS
authors: Camus
authors: K K
authors: KK
authors: Dockery
authors: A M
authors: AM
authors: Butler
mesh_terms: D000818:Animals; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D053673:Glypicans / Q000378:metabolism; D007900:Lemur; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D018419:Primate Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen; D053673:Glypicans