title: Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms.
abstract: CONCLUSIONS
  Gibberellic acids (GAs) are key plant hormones, regulating various aspects of growth and development, which have been at the center of the 'green revolution'. GRAS family proteins, the primary players in GA signaling pathways, remain poorly understood. Using sequence-profile searches, structural comparisons and phylogenetic analysis, we establish that the GRAS family first emerged in bacteria and belongs to the Rossmann fold methyltransferase superfamily. All bacterial and a subset of plant GRAS proteins are likely to function as small-molecule methylases. The remaining plant versions have lost one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. We predict that GRAS proteins might either modify or bind small molecules such as GAs or their derivatives.
  
  
  BACKGROUND
  aravind@ncbi.nlm.nih.gov
  
  
  BACKGROUND
  Supplementary Material for this article is available at Bioinformatics online.
authors: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
authors: Dapeng
authors: D
authors: Zhang
authors: Lakshminarayan M
authors: LM
authors: Iyer
authors: L
authors: L
authors: Aravind
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D005875:Gibberellins / Q000378:metabolism*; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D010944:Plants / Q000201:enzymology; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D015398:Signal Transduction / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D005875:Gibberellins; D010940:Plant Proteins; C007842:gibberellic acid; D008780:Methyltransferases