title: Blood lead, calcium, and phosphorus in women with preeclampsia in Edo State, Nigeria.
abstract: The authors investigated the effect of blood lead (BPb) and its relationship with calcium and phosphorus in the development of preeclampsia in Nigeria. Blood samples were collected from 59 preclamptics, 150 normal pregnant, and 122 nonpregnant women. Blood lead and serum Ca and P were determined. Blood lead was significantly higher (p < .001), whereas serum Ca and P were significantly lower (p < .001) in preclamptics than in normal pregnant women (60.2 ± 12.8 vs 26.3 ± 8.0 μg/dL for Pb, 1.39 ± 0.33 vs 2.03 ± 0.22 mmol/L for Ca, and 0.76 ± 0.10 vs 0.99 ± 0.13 mmol/L for P, respectively). There was significant increase (p < .05) in BPb and decreases (p < .01) in serum Ca and P in pregnant women than in nonpregnant women (35.7 ± 18.0 vs 13.1 ± 6.4 μg/dL for Pb, 1.85 ± 0.33 vs 2.33 ± 0.20 mmol/L for Ca, and 0.93 ± 0.38 vs 1.24 ± 0.26 mmol/L for P). Also, BPb was negatively correlated with serum Ca and, P, and positively correlated with systolic and diastolic blood pressures in pregnancy (r = -.804 for Ca, r = -.728 for P, r = .908 for SBP, and r = .842 for DBP) and preeclampsia (p < .01). It appears that increase in blood lead, which parallels decreases in serum calcium and phosphorus, may be related to the development and progression of preeclampsia in this environment.
authors: Department of Chemical Pathology, School of Clinical Medicine, Igbinedion University Okada, Edo State, Nigeria. iykeikaraoha@yahoo.com
authors: Ikaraoha Chidiebere
authors: IC
authors: Ikechukwu
authors: Oforofuo Isreal Agware
authors: OI
authors: Ojareva
authors: Anetor John
authors: AJ
authors: Ibhagbemien
authors: Okogbo Felix
authors: OF
authors: Okhoaretor
authors: Okusanya Babasola
authors: OB
authors: Oluwatomi
authors: Okogbenin Sylvanus
authors: OS
authors: Akhalufo
authors: Alonge Temitope
authors: AT
authors: Oluwagbenga
authors: Mbadiwe Nkeiruka
authors: MN
authors: Chigaekwu
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002118:Calcium / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007854:Lead / Q000097:blood*; D009549:Nigeria; D010758:Phosphorus / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D010758:Phosphorus; D007854:Lead; D002118:Calcium