title: Salusins, newly identified regulators of hemodynamics and mitogenesis, increase in polycystic ovarian syndrome.
abstract: In the current study, we aimed to investigate whether serum salusin α and β levels are different in PCOS subjects. Fifty women with PCOS and 50 healthy, age- and body mass index matched controls were included to the prospective cross-sectional study. All subjects underwent venous blood drawing on the early follicular phase after an overnight fasting. Serum salusin α and β levels were measured with EIA, and ELISA respectively. The relationships between serum salusin levels and anthropometric and metabolic parameters were also assessed. Plasma salusin α and β levels were higher in women with PCOS compared to control group. Serum salusin α level correlated positively with salusin β and fasting serum insulin levels. The serum salusin β levels were correlated positively with HOMA-IR, TG, LDL-C, LH, FSH, and total testosterone levels. Our results indicate that salusins, newly identified regulators of hemodynamics and mitogenesis, are increased within the serum of women with PCOS.
authors: Department of Obstetrics and Gynecology, Inonu University, Medical Faculty, Malatya, Turkey. oncelik@inonu.edu.tr
authors: Önder
authors: Ö
authors: Celik
authors: Ercan
authors: E
authors: Yılmaz
authors: Nilüfer
authors: N
authors: Celik
authors: Yagmur
authors: Y
authors: Minareci
authors: Ilgin
authors: I
authors: Turkcuoglu
authors: Yavuz
authors: Y
authors: Simsek
authors: Ebru
authors: E
authors: Celik
authors: Abdullah
authors: A
authors: Karaer
authors: Suleyman
authors: S
authors: Aydin
mesh_terms: D000328:Adult; D002455:Cell Division / Q000502:physiology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000502:physiology*; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D011446:Prospective Studies; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; C478739:TOR2A protein, human; D013739:Testosterone; D007986:Luteinizing Hormone