title: Antibodies generated against conserved antigens expressed by bacteria and allergen-bearing fungi suppress airway disease.
abstract: There has been a sharp rise in allergic asthma and asthma-related deaths in the developed world, in contrast to many childhood illnesses that have been reduced or eliminated. The hygiene hypothesis proposes that excessively sanitary conditions early in life result in autoimmune and allergic phenomena because of a failure of the immune system to receive proper microbial stimulation during development. We demonstrate that Abs generated against conserved bacterial polysaccharides are reactive with and dampen the immune response against chitin and Aspergillus fumigatus. A reduction in Ag uptake, cell influx, cell activation, and cytokine production occurred in the presence of anti-polysaccharide Abs, resulting in a striking decrease in the severity of allergic airway disease in mice. Overall, our results suggest that Ag exposure--derived from environmental sources, self-antigens, or vaccination--during the neonatal period has dramatic effects on the adult Ab response and modifies the development of allergic airway disease.
authors: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors: Nicholas W
authors: NW
authors: Kin
authors: Emily K
authors: EK
authors: Stefanov
authors: Brian L P
authors: BL
authors: Dizon
authors: John F
authors: JF
authors: Kearney
mesh_terms: D000375:Aging / Q000276:immunology; D000485:Allergens / Q000096:biosynthesis* / Q000276:immunology / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000502:physiology; D001232:Aspergillus fumigatus / Q000276:immunology*; D002478:Cells, Cultured; D002686:Chitin / Q000037:antagonists & inhibitors / Q000378:metabolism; D017124:Conserved Sequence / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D060467:Disease Resistance / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D055732:Pulmonary Aspergillosis / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D000485:Allergens; D000907:Antibodies, Bacterial; D002686:Chitin