title: The ubiquity of iron.
abstract: The importance of iron in living systems can be traced to the many complexes within which it is found, to its chemical mobility in undergoing oxidation-reduction reactions, and to the abundance of iron in Earth's crust. Iron is the most abundant element, by mass, in the Earth, constituting about 80% of the inner and outer cores of Earth. The molten outer core is about 8000 km in diameter, and the solid inner core is about 2400 km in diameter. Iron is the fourth most abundant element in Earth's crust. It is the chemically functional component of mononuclear iron complexes, dinuclear iron complexes, [2Fe-2S] and [4Fe-4S] clusters, [Fe-Ni-S] clusters, iron protophorphyrin IX, and many other complexes in protein biochemistry. Metals such as nickel, cobalt, copper, and manganese are present in the crust and could in principle function chemically in place of iron, but they are scarce in Earth's crust. Iron is plentiful because of its nuclear stability in stellar nuclear fusion reactions. It seems likely that other solid planets, formed by the same processes as Earth, would also foster the evolution of life and that iron would be similarly important to life on those planets as it is on Earth.
authors: Department of Biochemistry, University of Wisconsin-Madison, 1710 University Avenue, Madison, WI 53726, USA. frey@biochem.wisc.edu
authors: Perry A
authors: PA
authors: Frey
authors: George H
authors: GH
authors: Reed
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry / Q000378:metabolism; D018534:Earth, Planet; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D033862:Iron-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D009584:Nitrogen / Q000737:chemistry / Q000378:metabolism
chemical_list: D033862:Iron-Binding Proteins; D002244:Carbon; D007501:Iron; D009584:Nitrogen