title: Absolute bioavailability of himantane in rabbits.
abstract: Pharmacokinetic parameters of himantane and its metabolites in the blood plasma of rabbits were compared after single administration of himantane solution in a dose of 25 mg intravenously and 100 mg orally. It was established that the original substance is characterized by low absolute bioavailability (7.95%). Himantane is subjected to first-pass effect and is extensively metabolized in the liver to metabolites with m/z 266 and 250.
authors: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. zlanomar@gmail.com
authors: E A
authors: EA
authors: Litvin
authors: D V
authors: DV
authors: Bastrygin
authors: G B
authors: GB
authors: Kolyvanov
authors: K V
authors: KV
authors: Alekseev
authors: V P
authors: VP
authors: Zherdev
mesh_terms: D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D018592:Cross-Over Studies; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011817:Rabbits
chemical_list: C122112:N-(2-adamantyl)hexamethylenimine; D000218:Adamantane