title: Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance.
abstract: In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.
authors: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.
authors: Tomohiro
authors: T
authors: Minakawa
authors: Kazufumi
authors: K
authors: Toume
authors: Midori A
authors: MA
authors: Arai
authors: Samir K
authors: SK
authors: Sadhu
authors: Firoj
authors: F
authors: Ahmed
authors: Masami
authors: M
authors: Ishibashi
mesh_terms: D001459:Bangladesh; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000187:drug effects*; D043982:Rhizophoraceae / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000188:drug therapy
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D045787:Sesquiterpenes, Eudesmane