title: The secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement.
abstract: The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.
authors: RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. alexander.bukreyev@utmb.edu.
authors: Alexander
authors: A
authors: Bukreyev
authors: Lijuan
authors: L
authors: Yang
authors: Peter L
authors: PL
authors: Collins
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry; D000941:Antigens / Q000737:chemistry; D003062:Codon; D003165:Complement System Proteins / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008168:Lung / Q000166:cytology; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D009504:Neutrophils / Q000166:cytology; D018357:Respiratory Syncytial Virus Infections / Q000378:metabolism / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000378:metabolism*
chemical_list: D000906:Antibodies; D000941:Antigens; D003062:Codon; D006023:Glycoproteins; D014759:Viral Envelope Proteins; C116204:attachment protein G; D003165:Complement System Proteins