title: Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis.
abstract: Many works have demonstrated the real potential of gentamicin-monoolein-water formulations as bioresorbable and sustained-release implants for the local treatment of the chronic osteomyelitis. In order to improve the efficacy of this type of implant, the incorporation of hydroxyapatite, a well-known osteointegrator material, is thought to be an interesting approach. Five formulations incorporating 0, 2.5, 5, 10, and 20% of hydroxyapatite were examined with regard to their physicochemical and in vitro drug release characteristics. The rheological, thermal (differential scanning calorimetric and thermogravimetric diffraction analysis), X-ray diffraction, and dissolution studies have showed that the presence of hydroxyapatite does not dramatically disturb the cubic liquid crystalline structure of the monoolein-water gel and their ability to progressively release the antibiotic. Implant 20% that was capable to release gentamicin sulfate over a period of four weeks without marked burst effect could be used as a more suitable biodegradable delivery system for the local management of chronic osteomyelitis.
authors: Department of Applied Pharmaceutical Sciences, UFR/SDSS, University of Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso, West Africa.
authors: Rasmané
authors: R
authors: Semdé
authors: Réné Flore Gueu
authors: RF
authors: Gondi
authors: Bavouma Charles
authors: BC
authors: Sombié
authors: B Gérard Josias
authors: BG
authors: Yaméogo
authors: Moustapha
authors: M
authors: Ouédraogo