title: In vivo biomechanical stability of osseointegrating mesoporous TiO(2) implants.
abstract: Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.
authors: Department of Chemical and Biological Engineering, Applied Chemistry, Chalmers University of Technology, Gothenburg, Sweden.
authors: Johan
authors: J
authors: Karlsson
authors: Ryo
authors: R
authors: Jimbo
authors: Hoda M
authors: HM
authors: Fathali
authors: Humberto Osvaldo
authors: HO
authors: Schwartz-Filho
authors: Mariko
authors: M
authors: Hayashi
authors: Mats
authors: M
authors: Halvarsson
authors: Ann
authors: A
authors: Wennerberg
authors: Martin
authors: M
authors: Andersson
mesh_terms: D000818:Animals; D001031:Apatites / Q000737:chemistry / Q000378:metabolism; D018786:Bone Substitutes / Q000737:chemistry*; D008422:Materials Testing; D016348:Osseointegration; D016062:Porosity; D011817:Rabbits; D014025:Titanium / Q000737:chemistry*
chemical_list: D001031:Apatites; D018786:Bone Substitutes; C009495:titanium dioxide; D014025:Titanium