title: Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats.
abstract: OBJECTIVE
  To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ∼0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow.
  
  
  BACKGROUND
  Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors.
  
  
  METHODS
  Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow.
  
  
  RESULTS
  Expressions of p53 decreased ∼50% ∼with RW and LRS (p < 0.05 vs. C), p16 by ∼29% with RW (p < 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length >6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO(2) min(-1) kg(-1)), and RW or LRS also improved time of exercise tolerance vs. C (p < 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS.
  
  
  CONCLUSIONS
  RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.
authors: Clinical Division, Heart Institute (Incor), School of Medicine, University of São Paulo, SP, Brazil. protasio.luz@incor.usp.br
authors: Protásio L
authors: PL
authors: da Luz
authors: Leonardo
authors: L
authors: Tanaka
authors: Patrícia Chakur
authors: PC
authors: Brum
authors: Paulo Magno Martins
authors: PM
authors: Dourado
authors: Desidério
authors: D
authors: Favarato
authors: José Eduardo
authors: JE
authors: Krieger
authors: Francisco Rafael M
authors: FR
authors: Laurindo
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001808:Blood Vessels / Q000502:physiology; D045462:Endothelium-Dependent Relaxing Factors / Q000378:metabolism; D005080:Exercise Test; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D016615:Telomere / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014920:Wine
chemical_list: D045462:Endothelium-Dependent Relaxing Factors; D013267:Stilbenes; D016159:Tumor Suppressor Protein p53; D000077185:Resveratrol