title: Direct synthesis of β-alkyl N-aryl aza Baylis-Hillman adducts via nitroso-ene reaction.
abstract: A new approach for the direct Fe-catalyzed synthesis of β-alkyl N-aryl aza Baylis-Hillman (ABH) adducts is reported. This approach involves the formation of a C-N bond via a nitroso-ene reaction. This is a simple, fast, and best alternate method to overcome the substrate scope limitations of the ABH reaction, which converts allyl esters and carbonyl compounds to novel ABH adducts. A variety of arylhydroxylamines reacted with esters, aldehydes, ketone, and nitriles to yield the corresponding products in moderate to excellent yields.
authors: Department of Chemistry, University of Louisiana at Lafayette, Lafayette, Louisiana 70504, United States.
authors: Siva
authors: S
authors: Murru
authors: August A
authors: AA
authors: Gallo
authors: Radhey S
authors: RS
authors: Srivastava
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000498:Allyl Compounds / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D004952:Esters; D006898:Hydroxylamines / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000498:Allyl Compounds; D001372:Aza Compounds; D004952:Esters; D006898:Hydroxylamines; D007659:Ketones; D009570:Nitriles; D007501:Iron