title: Dietary conjugated nonadecadienoic acid prevents adult-onset obesity in nescient basic helix-loop-helix 2 knockout mice.
abstract: Conjugated linoleic acid (CLA) has been extensively studied during the last two decades with regard to its effects on controlling body composition. As a cognate to CLA, conjugated nonadecadienoic acid (CNA) has been previously reported to reduce body fat more effectively than CLA. However, it is not known whether CNA supplementation can influence adult-onset obesity. Thus, the purpose of this study was to evaluate the effects of dietary CNA on the prevention of adult-onset inactivity-induced obesity using nescient basic helix-loop-helix 2 knockout (N2KO) mice. CNA supplementation at 0.1 w/w% level starting in the preobese state significantly prevented the reduction of voluntary movement and the increase in weight gain in N2KO mice during the experimental period compared to wild-type animals. In both wild-type and N2KO mice, respiratory exchange ratio was significantly reduced by CNA treatment during light and dark cycles, and dietary CNA significantly increased energy expenditure in N2KO mice. Selected gene expression profiles in white adipose tissue, muscle or liver showed a beneficial action of CNA on lipid metabolism and energy expenditure. These findings suggest that CNA could prevent adult-onset obesity by enhancing voluntary activity and energy expenditure in N2KO mice.
authors: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
authors: Jun Ho
authors: JH
authors: Kim
authors: Yooheon
authors: Y
authors: Park
authors: Daeyoung
authors: D
authors: Kim
authors: Deborah J
authors: DJ
authors: Good
authors: Yeonhwa
authors: Y
authors: Park
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D019587:Dietary Supplements; D004734:Energy Metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D005951:Glucose Tolerance Test; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009765:Obesity / Q000517:prevention & control*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005231:Fatty Acids, Unsaturated; D020738:Leptin; D012333:RNA, Messenger; D014280:Triglycerides; C404168:5,9-nonadecadienoic acid; C484104:Nhlh2 protein, mouse