title: Quantitative analysis of troponin I serum values in patients with acute cholecystitis.
abstract: The diagnosis and staging of acute cholecystitis, upon a lot of diagnostic methods and some scoring systems, is still a great clinical problem. The aim of the study was to investigate if serum Troponin I is elevated in patients with acute cholecystitis. Following informed consent, 65 patients with clinical and laboratory signs of acute cholecystitis were enrolled. All patients had measured serum Troponin I level and an abdominal ultrasound was done before definitive treatment was performed. Increased serum Troponin I level was found in most patients with severe form of acute cholecystitis (p < 0.00001). It reached sensitivity of 94.5% and specificity of 57.1% of this test. In multiple regression analysis Troponin I significantly correlated (p < 0.05) with the serum aspartate aminotransferase (r = 0.27), gamma-glutamyl transferase (r = 0.25) and gallbladder wall (> 6 mm) thickness (r = 0.58). Our study confirms that in most patients with severe and acute cholecystitis, serum Troponin I is increased. Troponin I level is in a lower range than it would be in patients with cardiac muscle damage or necrosis. Measuring serum Troponin I is a fast, reliable and widely performed test that could, with other routinely measured parameters, help in early diagnosis of the severe form of acute cholecystitis.
authors: University of Zagreb, School of Medicine, Dubrava University Hospital, Department of Internal Medicine, Zagreb, Croatia. zarko.babic@zg.t-com.hr
authors: Zarko
authors: Z
authors: Babić
authors: Zoran
authors: Z
authors: Bogdanović
authors: Zdravko
authors: Z
authors: Dorosulić
authors: Merita
authors: M
authors: Basha
authors: Zeljko
authors: Z
authors: Krznarić
authors: Ivo
authors: I
authors: Sjekavica
authors: Milan
authors: M
authors: Kujundzić
authors: Mario
authors: M
authors: Tadić
authors: Marko
authors: M
authors: Banić
authors: Vjekoslav
authors: V
authors: Jagić
authors: Marinko
authors: M
authors: Marusić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D041881:Cholecystitis, Acute / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I