title: Compartmentalized control of skin immunity by resident commensals.
abstract: Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. However, the contribution of tissue-resident commensals to immunity and inflammation at other barrier sites has not been addressed. We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function. Protective immunity to a cutaneous pathogen was found to be critically dependent on the skin microbiota but not the gut microbiota. Furthermore, skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor. These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.
authors: Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
authors: Shruti
authors: S
authors: Naik
authors: Nicolas
authors: N
authors: Bouladoux
authors: Christoph
authors: C
authors: Wilhelm
authors: Michael J
authors: MJ
authors: Molloy
authors: Rosalba
authors: R
authors: Salcedo
authors: Wolfgang
authors: W
authors: Kastenmuller
authors: Clayton
authors: C
authors: Deming
authors: Mariam
authors: M
authors: Quinones
authors: Lily
authors: L
authors: Koo
authors: Sean
authors: S
authors: Conlan
authors: Sean
authors: S
authors: Spencer
authors: Jason A
authors: JA
authors: Hall
authors: Amiran
authors: A
authors: Dzutsev
authors: Heidi
authors: H
authors: Kong
authors: Daniel J
authors: DJ
authors: Campbell
authors: Giorgio
authors: G
authors: Trinchieri
authors: Julia A
authors: JA
authors: Segre
authors: Yasmine
authors: Y
authors: Belkaid
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D007422:Intestines / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D054892:Metagenome / Q000276:immunology*; D051379:Mice; D012867:Skin / Q000276:immunology* / Q000382:microbiology*; D017192:Skin Diseases, Bacterial / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*