title: Which is a more accurate predictor in colorectal survival analysis? Nine data mining algorithms vs. the TNM staging system.
abstract: OBJECTIVE
  Over the past decades, many studies have used data mining technology to predict the 5-year survival rate of colorectal cancer, but there have been few reports that compared multiple data mining algorithms to the TNM classification of malignant tumors (TNM) staging system using a dataset in which the training and testing data were from different sources. Here we compared nine data mining algorithms to the TNM staging system for colorectal survival analysis.
  
  
  METHODS
  Two different datasets were used: 1) the National Cancer Institute's Surveillance, Epidemiology, and End Results dataset; and 2) the dataset from a single Chinese institution. An optimization and prediction system based on nine data mining algorithms as well as two variable selection methods was implemented. The TNM staging system was based on the 7(th) edition of the American Joint Committee on Cancer TNM staging system.
  
  
  RESULTS
  When the training and testing data were from the same sources, all algorithms had slight advantages over the TNM staging system in predictive accuracy. When the data were from different sources, only four algorithms (logistic regression, general regression neural network, bayesian networks, and Naïve Bayes) had slight advantages over the TNM staging system. Also, there was no significant differences among all the algorithms (p>0.05).
  
  
  CONCLUSIONS
  The TNM staging system is simple and practical at present, and data mining methods are not accurate enough to replace the TNM staging system for colorectal cancer survival prediction. Furthermore, there were no significant differences in the predictive accuracy of all the algorithms when the data were from different sources. Building a larger dataset that includes more variables may be important for furthering predictive accuracy.
authors: Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, PR China.
authors: Peng
authors: P
authors: Gao
authors: Xin
authors: X
authors: Zhou
authors: Zhen-ning
authors: ZN
authors: Wang
authors: Yong-xi
authors: YX
authors: Song
authors: Lin-lin
authors: LL
authors: Tong
authors: Ying-ying
authors: YY
authors: Xu
authors: Zhen-yu
authors: ZY
authors: Yue
authors: Hui-mian
authors: HM
authors: Xu
mesh_terms: D000465:Algorithms; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D057225:Data Mining / Q000379:methods*; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D012372:ROC Curve; D016019:Survival Analysis