title: Features and outcome after liver resection for non-B non-C hepatocellular carcinoma.
abstract: OBJECTIVE
  We investigated the clinicopathological findings and outcome after surgery for hepatocellular carcinoma in patients without hepatitis B or C virus infection.
  
  
  METHODS
  Among 562 patients who underwent curative resection for hepatocellular carcinoma, the sera from 97 patients (B group) were positive for hepatitis B surface antigen alone, sera from 355 patients (C group) were positive for anti-hepatitis C virus antibody alone and sera from 104 patients (NBNC group) were negative for both hepatitis B surface antigen and anti-hepatitis C virus antibody. We compared the clinicopathological findings and postoperative outcomes in the 3 groups.
  
  
  RESULTS
  The prevalence of diabetes mellitus, hypertension, hyperlipidemia and alcohol abuse were higher in the NBNC group than in the other groups. The prevalence of obesity was higher in the NBNC group than in the B group. Non-alcoholic steatohepatitis was detected in 16 NBNC patients. The tumor- free survival rate was higher in the NBNC group than in the C group.
  
  
  CONCLUSIONS
  Obesity, diabetes mellitus, hypertension, hyperlipidemia, alcohol abuse and non-alcoholic steatohepatitis were the possible risk factors for hepatocellular carcinoma in the NBNC group. The patients in the NBNC group are expected to show a better outcome as compared to patients in the C group.
authors: Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. m1295277@msic.med.osaka-cu.ac.jp
authors: Kazuhisa
authors: K
authors: Kaneda
authors: Shoji
authors: S
authors: Kubo
authors: Hiromu
authors: H
authors: Tanaka
authors: Shigekazu
authors: S
authors: Takemura
authors: Kazuki
authors: K
authors: Ohba
authors: Takahiro
authors: T
authors: Uenishi
authors: Shintaro
authors: S
authors: Kodai
authors: Hiroji
authors: H
authors: Shinkawa
authors: Yorihisa
authors: Y
authors: Urata
authors: Masayuki
authors: M
authors: Sakae
authors: Takatsugu
authors: T
authors: Yamamoto
authors: Shigefumi
authors: S
authors: Suehiro
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000821:virology; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006509:Hepatitis B / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies