title: Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.
abstract: L-Tyrosine is converted to 3-bromo-L-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-L-tyrosine in good yield. This is the simplest, safest and most efficient method for the preparation of gram quantities of either 3-bromo-L-tyrosine or 3,5-dibromo-L-tyrosine.
authors: Department of Chemistry, University of Georgia, Athens, GA 30602, USA. rsphillips@chem.uga.edu
authors: Robert S
authors: RS
authors: Phillips
authors: Susan
authors: S
authors: Busby
authors: Leia
authors: L
authors: Edenfield
authors: Kevin
authors: K
authors: Wickware
mesh_terms: D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D015394:Molecular Structure; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D014443:Tyrosine; D004121:Dimethyl Sulfoxide