title: Disorders of erythrocyte structure and function in hypertensive patients.
abstract: BACKGROUND
  The prevalence of hypertension is growing at an alarming rate. Increasing attention is being focussed on the oxidative stress accompanying this disease. In this study we examined the impact of this disease on some parameters of erythrocytes and human blood plasma.
  
  
  METHODS
  We examined the impact of hypertension on some parameters of erythrocytes and human plasma. The study involved 13 patients with hypertension and 19 healthy subjects. We determined lipid peroxidation, SH groups concentration, antioxidants enzymes activity, ATPase activity, total antioxidant capacity, total cholesterol level and erythrocyte membrane fluidity.
  
  
  RESULTS
  We found an increased level of lipid peroxidation and the concentration of SH groups in membrane proteins in patients with hypertension, and a decrease in the activity of catalase and superoxide dysmutase. No changes were observed in glutathione peroxidase and ATPase activity, level of total antioxidant capacity, total cholesterol level and fluidity of erythrocyte membranes.
  
  
  CONCLUSIONS
  These results suggest the existence of an impaired oxidative balance in hypertensive human erythrocytes.
authors: Department of Environment Pollution Biophysics, University of Lodz, Lodz, Poland. epytel@biol.uni.lodz.pl
authors: Edyta
authors: E
authors: Pytel
authors: Piotr
authors: P
authors: Duchnowicz
authors: Paulina
authors: P
authors: Jackowska
authors: Katarzyna
authors: K
authors: Wojdan
authors: Maria
authors: M
authors: Koter-Michalak
authors: Marlena
authors: M
authors: Broncel
mesh_terms: D000251:Adenosine Triphosphatases / Q000097:blood; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000473:pathology* / Q000502:physiology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology*; D015227:Lipid Peroxidation; D008297:Male; D008560:Membrane Fluidity; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000251:Adenosine Triphosphatases