title: Therapeutic angiogenesis: controlled delivery of angiogenic factors.
abstract: Therapeutic angiogenesis aims at treating ischemic diseases by generating new blood vessels from existing vasculature. It relies on delivery of exogenous factors to stimulate neovasculature formation. Current strategies using genes, proteins and cells have demonstrated efficacy in animal models. However, clinical translation of any of the three approaches has proved to be challenging for various reasons. Administration of angiogenic factors is generally considered safe, according to accumulated trials, and offers off-the-shelf availability. However, many hurdles must be overcome before therapeutic angiogenesis can become a true human therapy. This article will highlight protein-based therapeutic angiogenesis, concisely review recent progress and examine critical challenges. We will discuss growth factors that have been widely utilized in promoting angiogenesis and compare their targets and functions. Lastly, since bolus injection of free proteins usually result in poor outcomes, we will focus on controlled release of proteins.
authors: Departments of Bioengineering & Surgery, The McGowan Institute for Regenerative Medicine, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.
authors: Hunghao
authors: H
authors: Chu
authors: Yadong
authors: Y
authors: Wang
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage* / Q000737:chemistry; D042501:Angiogenic Proteins / Q000008:administration & dosage* / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000235:genetics; D033581:Stem Cell Transplantation; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D043925:Angiogenesis Inducing Agents; D042501:Angiogenic Proteins; D003692:Delayed-Action Preparations; D004337:Drug Carriers