title: Screening and analysis of the potential bioactive components in rabbit plasma after oral administration of hot-water extracts from leaves of Bambusa textilis McClure.
abstract: Bambusa textilis McClure is a traditional Chinese medicinal plant belonging to the Bambusoideae subfamily and used to treat chronic fever and infectious diseases. To investigate the bioactive compounds absorbed in the rabbit blood after oral administration of hot-water extracts from the leaves of B. textilis McClure, a validated chromatographic fingerprint method was established using LC-Q-TOF-MS. Twenty compounds in bamboo leaves and three potential bioactive compounds in rabbit plasma were detected. Of the twenty detected compounds in vitro, fifteen of which were tentatively identified either by comparing the retention time and mass spectrometry data with that of reference compounds or by reviewing the literature. Three potential bioactive compounds, including (E)-pcoumaric acid, (Z)-p-coumaric acid, and apigenin-8-C-β-D-(2"-O-α-L-rhamnosyl)-glucopyranoside, were detected in both the leaves of B. textilis McClure and rabbit plasma. Of the three compounds, apigenin-8-C-β-D-(2"-O-α-L-rhamnosyl)glucopyranoside was identified based on its UV, MS, and NMR spectra. This study provides helpful chemical information for further pharmacology and active mechanism research on B. textilis McClure.
authors: SFA Key Laboratory of Bamboo and Rattan Science and Technology, International Centre for Bamboo and Rattan, No. 8 Futong Dongdajie, Wangjing, Chaoyang District, Beijing 100102, China.
authors: Jin
authors: J
authors: Wang
authors: Yong-De
authors: YD
authors: Yue
authors: Feng
authors: F
authors: Tang
authors: Jia
authors: J
authors: Sun
mesh_terms: D000284:Administration, Oral; D000818:Animals; D031723:Bambusa / Q000737:chemistry*; D001774:Blood Chemical Analysis; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D003373:Coumaric Acids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D047309:Flavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics; D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D011422:Propionates; D011817:Rabbits; D012015:Reference Standards; D012997:Solvents / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000592:standards; D013056:Spectrophotometry, Ultraviolet; D053719:Tandem Mass Spectrometry / Q000592:standards; D014867:Water / Q000737:chemistry*
chemical_list: D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D047309:Flavones; D011422:Propionates; D012997:Solvents; C576567:apigenin-8-C-beta-D-(2''-O-alpha-L-rhamnosyl)-glucopyranoside; D014867:Water; C495469:p-coumaric acid