title: Amyotrophic lateral sclerosis with demyelinating neuropathy.
abstract: Amyotrophic lateral sclerosis (ALS) with demyelinating polyneuropathy is a rare condition. We describe two ALS patients with demyelinating neuropathy. Immunomodulatory therapies brought slight symptomatic benefits to the patients, but the treatments could not halt the progression of ALS. Chance coincidence of the two diseases is unlikely in view of the low prevalence. ALS, mainly consisting of progressive axonal degeneration, might show temporal demyelinating features of peripheral nerves both electrophysiologically and pathologically. The pathomechanism for the demyelination in ALS remains to be elucidated.
authors: Department of Neurology, Aomori Prefectural Central Hospital, Japan. hnishijima-tky@umin.ac.jp
authors: Haruo
authors: H
authors: Nishijima
authors: Masahiko
authors: M
authors: Tomiyama
authors: Chieko
authors: C
authors: Suzuki
authors: Tomoya
authors: T
authors: Kon
authors: Yukihisa
authors: Y
authors: Funamizu
authors: Tatsuya
authors: T
authors: Ueno
authors: Rie
authors: R
authors: Haga
authors: Yasuo
authors: Y
authors: Miki
authors: Akira
authors: A
authors: Arai
authors: Tamaki
authors: T
authors: Kimura
authors: Fumiaki
authors: F
authors: Mori
authors: Koichi
authors: K
authors: Wakabayashi
authors: Masayuki
authors: M
authors: Baba
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D055724:Electrophysiological Phenomena; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009431:Neural Conduction; D011115:Polyneuropathies / Q000150:complications* / Q000473:pathology / Q000503:physiopathology