title: Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.
abstract: BACKGROUND
  We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
  
  
  METHODS
  We used a case-control two-stage approach based on a discovery cohort (557 cases and ∼550 controls) and replication cohort (159 cases and 186 controls). The suicides were ascertained as consecutive cases autopsied at the Department of Forensic Medicine, Medical University of Warsaw, Poland.
  
  
  RESULTS
  In the discovery cohort we found an association between suicide and the CC genotype in the rs4307059 polymorphism (OR 1.64, p = 0.012). The trend for an overrepresentation of the CC homozygotes among suicides was replicated in the second cohort (OR 1.97, p = 0.056). Analysis in the pooled cohorts showed that rs4307059 CC was associated with completed suicide (OR 1.71, p = 0.002) also after Bonferroni correction (p(cor.) = 0.024). In an exploratory search for genotype-phenotype correlation we found that males with the rs4307059 CC genotype committed suicide earlier than those with CT/TT genotypes (p = 0.049).
  
  
  CONCLUSIONS
  The CC genotype of rs4307059 located in the region between CDH9 and CDH10 is associated with completed suicide in a Polish cohort.
authors: Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
authors: Izabela
authors: I
authors: Chojnicka
authors: Katarzyna
authors: K
authors: Strawa
authors: Sylwia
authors: S
authors: Fudalej
authors: Marcin
authors: M
authors: Fudalej
authors: Aleksandra
authors: A
authors: Pawlak
authors: Grażyna
authors: G
authors: Kostrzewa
authors: Marcin
authors: M
authors: Wojnar
authors: Paweł
authors: P
authors: Krajewski
authors: Rafał
authors: R
authors: Płoski
mesh_terms: D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D002135:Calcium-Binding Proteins; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D019006:Neural Cell Adhesion Molecules; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D020813:Receptor, trkB / Q000235:genetics; D013405:Suicide
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C107751:CDH10 protein, human; C430712:CDH9 protein, human; D015820:Cadherins; D002135:Calcium-Binding Proteins; D015816:Cell Adhesion Molecules, Neuronal; C539628:NRXN1 protein, human; D009419:Nerve Tissue Proteins; D019006:Neural Cell Adhesion Molecules; D020813:Receptor, trkB