title: Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways.
abstract: This study was designed to evaluate the effects and mechanism of Platycodi radix, having white balloon flower (Platycodon grandiflorum for. albiflorum (Honda) H. Hara) on obesity and insulin resistance. The extracts of Platycodi radix with white balloon flower were tested in cultured cells and administered into mice on a high-fat diet. The Platycodi radix activated the AMPK/ACC phosphorylation in C2C12 myotubes and also suppressed adipocyte differentiation in 3T3-L1 cells. In experimental animal, it suppressed the weight gain of obese mice and ameliorated obesity-induced insulin resistance. It also reduced the elevated circulating mediators, including triglyceride (TG), T-CHO, leptin, resistin, and monocyte chemotactic protein (MCP)-1 in obesity. As shown in C2C12 myotubes, the administration of Platycodi radix extracts also recovered the AMPK/ACC phosphorylation in the muscle of obese mice. These results suggest that Platycodi radix with white balloon flower ameliorates obesity and insulin resistance in obese mice via the activation of AMPK/ACC pathways and reductions of adipocyte differentiation.
authors: Biogeron Technology Research Group, Korea Food Research Institute, Baekhyon-dong 516, Bundang-gu, Songnam, Gyongki-do 463-746, Republic of Korea.
authors: Chae Eun
authors: CE
authors: Lee
authors: Haeng Jeon
authors: HJ
authors: Hur
authors: Jin-Taek
authors: JT
authors: Hwang
authors: Mi Jeong
authors: MJ
authors: Sung
authors: Hye Jeong
authors: HJ
authors: Yang
authors: Hyun-Jin
authors: HJ
authors: Kim
authors: Jae Ho
authors: JH
authors: Park
authors: Dae Young
authors: DY
authors: Kwon
authors: Myung-Sunny
authors: MS
authors: Kim