title: Splenomegaly during oxaliplatin-based chemotherapy for colorectal carcinoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate changes in splenic size and platelet counts, in patients with colorectal cancer during oxaliplatin based chemotherapy, and to determine their clinical significance.
  
  
  METHODS
  The prospectively archived records of 50 patients with colorectal cancer that received oxaliplatin-based chemotherapy were reviewed.
  
  
  RESULTS
  Thirty-eight men and 12 women, of median age 58 (range 35-77) years, were enrolled. Median spleen volume ratios were 1.3-fold after 6 cycles and 1.9-fold after 12 cycles. The incidence of splenomegaly was 30% after 6 cycles and 67% after 12 cycles, and of thrombocytopenia was 70% after 6 cycles, 82% after 9 cycles, and 80% after 12 cycles. Thrombocytopenia was found to be related to splenomegaly, and this pattern was notable after 6 cycles of chemotherapy.
  
  
  CONCLUSIONS
  Splenic enlargement and reduction in platelet counts were common during chemotherapy. Furthermore, these changes were found to occur rapidly after 6 cycles of chemotherapy.
authors: Department of Surgery, Colorectal Cancer Center, Konkuk University Medical Center, Konkuk University School of Medicine, 143-729, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, Republic of Korea.
authors: Eun-Joo
authors: EJ
authors: Jung
authors: Chun-Geun
authors: CG
authors: Ryu
authors: Gangmi
authors: G
authors: Kim
authors: Su Ran
authors: SR
authors: Kim
authors: Hee Sun
authors: HS
authors: Park
authors: Young Jun
authors: YJ
authors: Kim
authors: Dae-Yong
authors: DY
authors: Hwang
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D000077150:Oxaliplatin; D013163:Splenomegaly / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin