title: Yes-associated protein is not an independent prognostic marker in breast cancer.
abstract: BACKGROUND
  The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer.
  
  
  METHODS
  YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected.
  
  
  RESULTS
  There were 29 patients (30.8%) with 1(+) expression, in YAP, 59 patients (62.8%) with 2(+) expression and 6 (6.4%) with 3(+) expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate.
  
  
  CONCLUSIONS
  YAP expression is not an independent prognostic factor in patients with breast cancer.
authors: Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niao-Sung District, Kaohsiung, Taiwan. smsheen@yahoo.com
authors: Shyr-Ming
authors: SM
authors: Sheen-Chen
authors: Chun-Ying
authors: CY
authors: Huang
authors: Ching-Hua
authors: CH
authors: Tsai
authors: Yueh-Wei
authors: YW
authors: Liu
authors: Shih-Chung
authors: SC
authors: Wu
authors: Chao-Cheng
authors: CC
authors: Huang
authors: Hock-Liew
authors: HL
authors: Eng
authors: Yi-Chia
authors: YC
authors: Chan
authors: Sheung-Fat
authors: SF
authors: Ko
authors: Rei-Ping
authors: RP
authors: Tang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D014157:Transcription Factors / Q000378:metabolism*; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human