title: Short-term repeatability of resting myocardial blood flow measurements using rubidium-82 PET imaging.
abstract: BACKGROUND
  Rubidium-82 ((82)Rb) PET imaging has been proposed for routine myocardial blood flow (MBF) quantification. However, few studies have investigated the test-retest repeatability of this method. The aim of this study was to optimize same-day repeatability of rest MBF imaging with a highly automated analysis program (FlowQuant) using image-derived input functions and dual spillover corrections (SOC).
  
  
  METHODS
  Test-retest repeatability of resting left-ventricle (LV) MBF was measured in patients (n = 27) with suspected coronary artery disease (CAD) and healthy volunteers (n = 9). The effects of scan-time, reconstruction, and quantification methods were assessed with correlation and Bland-Altman repeatability coefficients.
  
  
  RESULTS
  Factors affecting rest MBF included gender, suspected CAD, and SOC (P < .001). Significant test-retest correlations were found using all analysis methods tested (r > 0.79). The best repeatability coefficient for same-day MBF was 0.20 mL/minute/g using a 6-minute scan-time, iterative reconstruction, SOC, resting rate-pressure-product (RPP) adjustment, and left atrium input function. This protocol was significantly less variable than standard protocols using filtered back-projection reconstruction, longer scan-time, no SOC, or LV input function.
  
  
  CONCLUSIONS
  Absolute MBF can be measured with good repeatability using FlowQuant analysis of (82)Rb PET scans with a 6-minute scan time, iterative reconstruction, dual SOC, RPP-adjustment, and an image-derived input function in the left atrium cavity.
authors: Carleton University, Ottawa, ON, Canada. matthewefseaff@gmail.com
authors: Matthew
authors: M
authors: Efseaff
authors: Ran
authors: R
authors: Klein
authors: Maria C
authors: MC
authors: Ziadi
authors: Rob S
authors: RS
authors: Beanlands
authors: Robert A
authors: RA
authors: deKemp
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes
chemical_list: D012414:Rubidium Radioisotopes