title: Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.
abstract: The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.
authors: Department of Cellular Neurobiology, University of Göttingen, Göttingen, Germany.
authors: Thomas
authors: T
authors: Effertz
authors: Björn
authors: B
authors: Nadrowski
authors: David
authors: D
authors: Piepenbrock
authors: Jörg T
authors: JT
authors: Albert
authors: Martin C
authors: MC
authors: Göpfert
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D057506:Arthropod Antennae / Q000502:physiology; D001306:Auditory Pathways / Q000502:physiology*; D003627:Data Interpretation, Statistical; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D015640:Ion Channel Gating / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008959:Models, Neurological; D009154:Mutation / Q000502:physiology; D058618:Sensilla / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; C405783:NOMPC protein, Drosophila; D050051:Transient Receptor Potential Channels