title: Association of blood group A with coronary artery disease in young adults in Taiwan.
abstract: OBJECTIVE
  We aimed to investigate the association between the ABO blood groups and the risk of coronary artery disease (CAD) and myocardial infartion (MI) in a young Taiwanese population.
  
  
  METHODS
  We retrospectively recruited 277 consecutive subjects (men younger than 45 years and women younger than 55 years) who underwent coronary angiography (136 with documented CAD and 129 without CAD) at our center, between 2005 and 2008. Their ABO blood groups were determined using standard agglutination techniques.
  
  
  RESULTS
  Patients with CAD showed a significantly different blood group distribution (O, 30.1%; A, 39.7%; B, 26.5%; AB, 3.7%) than that shown by the controls (O, 42.6%; A, 24.0%; B, 27.1%; AB, 6.2%; p=0.032). Patients with blood group A had a greater risk of CAD and MI than those with non-A blood groups (OR=2.08, 95% CI=1.23-3.54; OR=2.21, 95% CI=1.19-4.09, respectively). After adjustment for common cardiovascular risk factors such as age, gender, hypertension, cigarette smoking, diabetes mellitus, body mass index, family history of CAD, and lipid profiles; blood group A remained significantly associated with an increased risk of CAD and MI (OR=2.61, 95% CI 1.11-6.14, p=0.028; OR=3.53, 95% CI=1.21-10.29, p=0.021, respectively).
  
  
  CONCLUSIONS
  Our findings suggest that blood group A is an independent risk factor for CAD and MI in young people in Taiwan.
authors: The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.
authors: Hsin-Fu
authors: HF
authors: Lee
authors: Yen-Chen
authors: YC
authors: Lin
authors: Chia-Pin
authors: CP
authors: Lin
authors: Chun-Li
authors: CL
authors: Wang
authors: Chi-Jen
authors: CJ
authors: Chang
authors: Lung-An
authors: LA
authors: Hsu
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000017:ABO Blood-Group System; D008055:Lipids