title: Simultaneous determination of ascorbic acid, dopamine, uric acid and tryptophan on gold nanoparticles/overoxidized-polyimidazole composite modified glassy carbon electrode.
abstract: A novel electrode was developed through electrodepositing gold nanoparticles (GNPs) on overoxidized-polyimidazole (PImox) film modified glassy carbon electrode (GCE). The combination of GNPs and the PImox film endowed the GNPs/PImox/GCE with good biological compatibility, high selectivity and sensitivity and excellent electrochemical catalytic activities towards ascorbic acid (AA), dopamine (DA), uric acid (UA) and tryptophan (Trp). In the fourfold co-existence system, the peak separations between AA-DA, DA-UA and UA-Trp were large up to 186, 165 and 285 mV, respectively. The calibration curves for AA, DA and UA were obtained in the range of 210.0-1010.0 μM, 5.0-268.0 μM and 6.0-486.0 μM with detection limits (S/N=3) of 2.0 μM, 0.08 μM and 0.5 μM, respectively. Two linear calibrations for Trp were obtained over ranges of 3.0-34.0 μM and 84.0-464.0 μM with detection limit (S/N=3) of 0.7 μM. In addition, the modified electrode was applied to detect AA, DA, UA and Trp in samples using standard addition method with satisfactory results.
authors: Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors: Cun
authors: C
authors: Wang
authors: Ruo
authors: R
authors: Yuan
authors: Yaqin
authors: Y
authors: Chai
authors: Shihong
authors: S
authors: Chen
authors: Fangxin
authors: F
authors: Hu
authors: Meihe
authors: M
authors: Zhang
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis / Q000097:blood / Q000737:chemistry / Q000652:urine; D002244:Carbon / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis / Q000097:blood / Q000737:chemistry / Q000652:urine; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D013997:Time Factors; D014364:Tryptophan / Q000032:analysis / Q000097:blood / Q000737:chemistry / Q000652:urine; D014527:Uric Acid / Q000032:analysis / Q000097:blood / Q000737:chemistry / Q000652:urine
chemical_list: D007093:Imidazoles; D011108:Polymers; D014527:Uric Acid; D002244:Carbon; D006046:Gold; D014364:Tryptophan; D001205:Ascorbic Acid; D004298:Dopamine