title: Angiotensinogen gene M235T polymorphism and risk of coronary artery disease: a meta-analysis.
abstract: The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked with susceptibility to coronary artery disease (CAD). In the present study, a meta-analysis was performed to assess the correlation between the M235T polymorphism and CAD. Nine studies with a total of 2281 subjects were selected for inclusion in the analysis. The references were retrieved via PubMed, China National Knowledge Infrastructure, Wanfang and VIP database (1995.1-2012.1). The analyses were performed using STATA 10.0 software. Odds ratios (OR) with 95% confidence intervals (CIs) were assessed after the collected data were pooled for analysis. A significant association was detected between M235T gene polymorphism and CAD in the population studied. The estimates (OR) of CAD risk were calculated in a homozygote comparison (OR=1.54; 95% CI, 1.09-2.16), a heterozygote comparison (OR=1.30; 95% CI, 1.07-1.58), a dominant model (OR=0.72; 95% CI, 0.55-0.94) and a recessive model (OR=1.37; 95% CI, 0.98-1.91). The current meta-analysis suggests that the M235T polymorphism is associated to an increased risk of CAD.
authors: Cardiovascular Department, The First Affiliated Hospital of Yangtze University, Medical College of Yangtze University, Shashi District, Jingzhou, Hubei 434000, PR China. wyj312@hotmail.com
authors: Yu-Jing
authors: YJ
authors: Wang
authors: Yan
authors: Y
authors: Pan
mesh_terms: D000808:Angiotensinogen / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D016208:Databases, Factual; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D000808:Angiotensinogen