title: Changing the tumor microenvironment: new strategies for immunotherapy.
abstract: Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network that must be overcome to achieve eradication of established tumors by immunotherapy. On March 21-22, 2012, a symposium was held in Pamplona, Spain, to share the recent advances regarding the molecules and cells that create and sustain this immune-hostile tumor microenvironment. Excellent targets for immunotherapeutic intervention were identified, and a number of therapeutic strategies under translation from mouse to human were presented.
authors: Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra Clinic, University of Navarra, Pamplona, Navarra, Spain.
authors: Pedro
authors: P
authors: Berraondo
authors: Viktor
authors: V
authors: Umansky
authors: Ignacio
authors: I
authors: Melero
mesh_terms: D000818:Animals; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D059016:Tumor Microenvironment