title: MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease.
abstract: Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chronic kidney disease (CKD). Xu et al. showed that miR-486 mimetic ameliorated muscle wasting in mice with CKD. miR mimetics may represent a new therapeutic frontier for muscle wasting in CKD.
authors: Robert H
authors: RH
authors: Mak
authors: Wai W
authors: WW
authors: Cheung
mesh_terms: D000818:Animals; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000209:etiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; C467200:Foxo1 protein, mouse; C583982:MIRN486 microRNA, mouse; D035683:MicroRNAs; D009124:Muscle Proteins