title: Small angle neutron scattering for the structural study of intrinsically disordered proteins in solution: a practical guide.
abstract: Small angle neutron scattering (SANS) allows studying bio-macromolecular structures and interactions in solution. It is particularly well-suited to study structural properties of intrinsically disordered proteins (IDPs) over a wide range of length-scales ranging from global aspects (radii of gyration and molecular weight) down to short-distance properties (e.g., cross-sectional analysis). In this book chapter, we provide a practical guide on how to carry out SANS experiments on IDPs and discuss the complementary aspects and strengths of SANS with respect to small angle X-ray scattering (SAXS).
authors: Institut de Biologie Structurale Jean-Pierre Ebel. UMR 5075 (CNRS, CEA, UJF), Grenoble, France. frank.gabel@ibs.fr
authors: Frank
authors: F
authors: Gabel
mesh_terms: D033363:Neutron Diffraction / Q000295:instrumentation / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D053838:Scattering, Small Angle; D012996:Solutions; D013223:Statistics as Topic
chemical_list: D011506:Proteins; D012996:Solutions