title: Topical therapies for periorbital cutaneous malignancies:  indications and treatment regimens.
abstract: OBJECTIVE
  To present a brief review of periorbital cutaneous tumorogenesis, highlighting the steps which might be amenable to topical treatments and then discuss the use of topical agents in the management of periorbital skin malignancy.
  
  
  RESULTS
  A rapid expansion in the understanding of the pathogenesis of melanoma and nonmelanoma skin cancer has allowed the development of a number of topical agents targeting specific tumor-forming processes. Topical agents have been shown to be effective in the management of periorbital skin malignancy.
  
  
  CONCLUSIONS
  5-Fluorouracil and imiquimod have established roles in the management of periorbital skin malignancy. Newer agents such as ingenol mebutate, tazarotene, and diclofenac gel probably have evolving roles that require further research but show promise.
authors: Eyelid, Lacrimal and Orbital Clinic, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. tjs001@bigpond.net.au
authors: Timothy J
authors: TJ
authors: Sullivan
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy*; D004224:Diterpenes / Q000008:administration & dosage / Q000627:therapeutic use; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D000077271:Imiquimod; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: C486592:3-ingenyl angelate; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D004224:Diterpenes; D016685:Mitomycin; D000077271:Imiquimod; D005472:Fluorouracil