title: Thrombotic microangiopathy associated with use of interferon-beta.
abstract: Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed.
authors: Department of Nephrology, Hospital Universitario La Paz, Madrid, Spain.
authors: Teresa
authors: T
authors: Olea
authors: Raquel
authors: R
authors: Díaz-Mancebo
authors: Maria-Luz
authors: ML
authors: Picazo
authors: Jorge
authors: J
authors: Martínez-Ara
authors: Angel
authors: A
authors: Robles
authors: Rafael
authors: R
authors: Selgas