title: Polymer nanoassemblies for cancer treatment and imaging.
abstract: Amphiphilic polymers represented by block copolymers self-assemble into well-defined nanostructures capable of incorporating therapeutics. Polymer nanoassemblies currently developed for cancer treatment and imaging are reviewed in this article. Particular attention is paid to three representative polymer nanoassemblies: polymer micelles, polymer micellar aggregates and polymer vesicles. Rationales, design and performance of these polymer nanoassemblies are addressed, focusing on increasing the solubility and chemical stability of drugs. Also discussed are polymer nanoassembly formation, the distribution of polymer materials in the human body and applications of polymer nanoassemblies for combined therapy and imaging of cancer. Updates on tumor-targeting approaches, based on preclinical and clinical results are provided, as well as solutions for current issues that drug-delivery systems have, such as in vivo stability, tissue penetration and therapeutic efficacy. These are discussed to provide insights on the future development of more effective polymer nanoassemblies for the delivery of therapeutics in the body.
authors: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, Lexington, KY 40536, USA.
authors: Hyun Jin
authors: HJ
authors: Lee
authors: Andrei
authors: A
authors: Ponta
authors: Younsoo
authors: Y
authors: Bae
mesh_terms: D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D008823:Micelles; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers