title: Therapeutic anticoagulation can be safely accomplished in selected patients with traumatic intracranial hemorrhage.
abstract: BACKGROUND
  Therapeutic anticoagulation is an important treatment of thromboembolic complications, such as DVT, PE, and blunt cerebrovascular injury. Traumatic intracranial hemorrhage has traditionally been considered to be a contraindication to anticoagulation.
  
  
  OBJECTIVE
  Therapeutic anticoagulation can be safely accomplished in select patients with traumatic intracranial hemorrhage.
  
  
  METHODS
  Patients who developed thromboembolic complications of DVT, PE, or blunt cerebrovascular injury were stratified according to mode of treatment. Patients who underwent therapeutic anticoagulation with a heparin infusion or enoxaparin (1 mg/kg BID) were evaluated for neurologic deterioration or hemorrhage extension by CT scan.
  
  
  RESULTS
  There were 42 patients with a traumatic intracranial hemorrhage that subsequently developed a thrombotic complication. Thirty-five patients developed a DVT or PE. Blunt cerebrovascular injury was diagnosed in four patients. 26 patients received therapeutic anticoagulation, which was initiated an average of 13 days after injury. 96% of patients had no extension of the hemorrhage after anticoagulation was started. The degree of hemorrhagic extension in the remaining patient was minimal and was not felt to affect the clinical course.
  
  
  CONCLUSIONS
  Therapeutic anticoagulation can be accomplished in select patients with intracranial hemorrhage, although close monitoring with serial CT scans is necessary to demonstrate stability of the hemorrhagic focus.
authors: Department of Trauma, North Memorial Medical Center, Robbinsdale, MN, USA. mbyrnes150@yahoo.com.
authors: Matthew C
authors: MC
authors: Byrnes
authors: Eric
authors: E
authors: Irwin
authors: Robert
authors: R
authors: Roach
authors: Molly
authors: M
authors: James
authors: Patrick K
authors: PK
authors: Horst
authors: Patty
authors: P
authors: Reicks