title: Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura.
abstract: Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP.
authors: Department of Dermatovenereology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, China.
authors: Tao
authors: T
authors: Chen
authors: Rui-zhen
authors: RZ
authors: Jia
authors: Zai-pei
authors: ZP
authors: Guo
authors: Na
authors: N
authors: Cao
authors: Meng-meng
authors: MM
authors: Li
authors: Xiao-yan
authors: XY
authors: Jiao
mesh_terms: D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000096:biosynthesis / Q000097:blood; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000097:blood; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000097:blood*; D008297:Male; D011956:Receptors, Cell Surface / Q000097:blood; D055815:Young Adult
chemical_list: D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D007070:Immunoglobulin A; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface; C087589:anti-endothelial cell antibody