title: Intrarenal urothelial transformation after obstruction: a novel metaplasia.
abstract: Obstructive nephropathy is a major cause of acute renal failure and end-stage renal disease. We discuss the new findings of Girshovich et al., who show that transformation of intrarenal urothelium into a bladder-like urothelium depends on the activation of the FGF7-FGFR2 signaling pathway following acute ureteral obstruction. A possible link between hypoxia-inducible factor 1α and the FGF-FGFR signaling pathway is suggested.
authors: Weei-Yuarn
authors: WY
authors: Huang
authors: Seymour
authors: S
authors: Rosen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D054338:Cell Transdifferentiation; D005260:Female; D007668:Kidney / Q000473:pathology*; D014517:Ureteral Obstruction / Q000473:pathology*; D001743:Urinary Bladder / Q000473:pathology*; D019459:Urothelium / Q000473:pathology*