title: Effect of Ala54Thr polymorphism of FABP2 on anthropometric and biochemical variables in response to a moderate-fat diet.
abstract: OBJECTIVE
  To analyze the effect of the fatty acid-binding protein (FABP2) gene Ala54Thr polymorphism on anthropometric and biochemical variables in response to a moderate-fat diet in overweight or obese subjects.
  
  
  METHODS
  One hundred nine subjects with a body mass index ≥ 25 kg/m(2) were studied. Participants underwent a dietary intervention that consisted of 30% fat (saturated fat <7% of total calories), 15% protein, and 55% carbohydrates. The FABP2 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Anthropometric and biochemical data were measured at baseline, 1 mo, and 2 mo of nutritional intervention.
  
  
  RESULTS
  The mean age was 38.6 ± 11.3 y and the mean body mass index 32.7 ± 6.1 kg/m(2), with 20 men (18%) and 89 women (82%). Fifty-three patients (48.6%) had genotype Ala54Ala (wild-type group) and 56 patients had genotype Ala54Thr/Thr54Thr (51.4%, mutant group). At baseline, no significant difference was found between the FABP2 genotypes groups, except for the carbohydrate intake and resting metabolic rate, which were higher in the Ala54Thr/Thr54Thr group (P < 0.05). At 2 mo, participants had lost 6.8% of their initial weight. The Ala54Thr/Thr54Thr group compared with the Ala54Ala group showed significant decreases in the parameters of weight (-7.5 versus -4.2 kg), body mass index (-2.1 versus -1.2 kg/m(2)), waist circumference (-7.6 versus -5.2 cm), waist-to-hip ratio (-0.04 versus -0.02), and C-reactive protein (-1.4 versus -0.76 mg/L), respectively (P < 0.05). After the resting metabolic rate was adjusted, the decreases in waist circumference, waist-to-hip ratio, and C-reactive protein remained significant between the two groups.
  
  
  CONCLUSIONS
  This study showed that the Thr54 allele carriers responded better to a moderate-fat diet.
authors: Deparment of Molecular Biology in Medicine, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. erikamtz27@yahoo.com.mx
authors: Erika
authors: E
authors: Martinez-Lopez
authors: Maritza R
authors: MR
authors: Garcia-Garcia
authors: Jorge M
authors: JM
authors: Gonzalez-Avalos
authors: Montserrat
authors: M
authors: Maldonado-Gonzalez
authors: Bertha
authors: B
authors: Ruiz-Madrigal
authors: Barbara
authors: B
authors: Vizmanos
authors: Zamira
authors: Z
authors: Hernandez-Nazara
authors: Sonia
authors: S
authors: Roman
authors: Arturo
authors: A
authors: Panduro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000886:Anthropometry; D001481:Basal Metabolism; D001483:Base Sequence; D015992:Body Mass Index; D001835:Body Weight; D004247:DNA / Q000235:genetics; D004041:Dietary Fats / Q000008:administration & dosage*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D050177:Overweight / Q000178:diet therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D004041:Dietary Fats; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D004247:DNA