title: Predictive genetic testing for drug-induced liver injury: considerations of clinical utility.
abstract: Genetic predisposition to drug-induced liver injury may be due to variation in both pharmacokinetic and pharmacodynamic pathways. Recent genome-wide association studies have identified, in the human leukocyte antigen (HLA) alleles, strong genetic factors that predispose to liver injury on exposure to any of several drugs. Although the genetic associations have provided mechanistic insights, none has been developed as a predictive test. Further work in this area, in combination with other "-omics" technologies, is needed to develop tests that are both clinically useful and cost-effective.
authors: Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
authors: A
authors: A
authors: Alfirevic
authors: M
authors: M
authors: Pirmohamed
mesh_terms: D000483:Alleles; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D012680:Sensitivity and Specificity
chemical_list: D006680:HLA Antigens