title: Chalinulasterol, a chlorinated steroid disulfate from the Caribbean sponge Chalinula molitba. Evaluation of its role as PXR receptor modulator.
abstract: Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed.
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors: Roberta
authors: R
authors: Teta
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors: Gerardo
authors: 0000-0001-8957-3259
authors: G
authors: Della Sala
authors: Department of Clinical and Experimental Medicine, University of Perugia, Via Gerardo Dottori 1, S. Andrea delle Fratte, 06132 Perugia, Italy.
authors: Barbara
authors: B
authors: Renga
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors: Alfonso
authors: 0000-0003-3910-6518
authors: A
authors: Mangoni
authors: Department of Clinical and Experimental Medicine, University of Perugia, Via Gerardo Dottori 1, S. Andrea delle Fratte, 06132 Perugia, Italy.
authors: Stefano
authors: S
authors: Fiorucci
authors: The NeaNat Group, Department of Chemistry of Natural Products, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors: Valeria
authors: 0000-0001-8723-9505
authors: V
authors: Costantino
mesh_terms: D000818:Animals; D017691:Caribbean Region; D045744:Cell Line, Tumor; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D011161:Porifera / Q000737:chemistry*; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D013258:Steroids, Chlorinated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013258:Steroids, Chlorinated