title: CD86 gene variants and susceptibility to pancreatic cancer.
abstract: BACKGROUND
  Pancreatic cancer is one of the most lethal cancers worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in tumor immunity. It has been reported that polymorphisms in CD86 gene can be involved in the development of various cancers. Here, we investigated the association of two CD86 polymorphisms, +1057G/A (rs1129055) and +2379G/C (rs17281995), with pancreatic cancer in the Chinese population.
  
  
  METHODS
  The two polymorphisms were identified in 369 pancreatic cancer patients and 412 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data were analyzed by chi-square test and adjusted for body mass index, smoking, drinking, and diabetes status.
  
  
  RESULTS
  Results showed that the frequency of the +1057A allele was significantly higher in pancreatic cancer cases than in controls (59.8 vs. 52.8 %, p = 0.021). Comparison of genotype frequencies showed that +1057GA and +1057AA genotypes were significantly increased in the pancreatic cancer group (odds ratio (OR) = 1.52; 95 % confidence interval (CI), 1.09-2.38; p = 0.026; and OR = 1.90; 95 % CI, 1.21-3.01; p = 0.007). We did not find any association between the +2379G/C polymorphism and pancreatic cancer. Analysis of haplotypes indicated that the AG (+1057, +2379) haplotype was correlated with the susceptibility to this disease (p = 0.019).
  
  
  CONCLUSIONS
  These results suggest that the CD86 +1057G/A polymorphism and AG (+1057, +2379) haplotype are genetic risk factors for pancreatic cancer.
authors: Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, 440 Chengdu North Road, Shanghai, 200003, China.
authors: Honggang
authors: H
authors: Xiang
authors: Wei
authors: W
authors: Zhao
authors: Yanping
authors: Y
authors: Sun
authors: Winnie
authors: W
authors: Qian
authors: Junjie
authors: J
authors: Xing
authors: Yujia
authors: Y
authors: Zhou
authors: Jun
authors: J
authors: Yao
authors: Jian
authors: J
authors: Xu
authors: Yi
authors: Y
authors: Wang
authors: Houshan
authors: H
authors: Yao
authors: Zhiqian
authors: Z
authors: Hu
mesh_terms: D000938:Antigen-Presenting Cells / Q000378:metabolism; D044466:Asian People; D051940:B7-2 Antigen / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D051940:B7-2 Antigen; C497964:CD86 protein, human