title: A modified glucomannan mycotoxin-adsorbing agent counteracts the reduced weight gain and diminishes cecal colonization of Salmonella Typhimurium in T-2 toxin exposed pigs.
abstract: The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23 days: (1) free of mycotoxins, (2) containing 1g binder per kg feed, (3) containing 83 μg T-2 toxin per kg feed and (4) containing 83 μg T-2 toxin and 1g binder per kg feed. After 18 days, all pigs were inoculated with Salmonella Typhimurium and euthanized five days later. The addition of the binder to T-2 toxin contaminated feed counteracted the reduced weight gain of pigs caused by T-2 toxin and reduced the amount of Salmonella Typhimurium in the cecum and cecal contents. In vitro findings might indicate that the binder captures Salmonella. We thus conclude that the binder counteracts T-2 toxin induced weight loss and possibly binds Salmonella, resulting in a reduced cecal colonization.
authors: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. elin.verbrugghe@ugent.be
authors: Elin
authors: E
authors: Verbrugghe
authors: Siska
authors: S
authors: Croubels
authors: Virginie
authors: V
authors: Vandenbroucke
authors: Joline
authors: J
authors: Goossens
authors: Patrick
authors: P
authors: De Backer
authors: Mia
authors: M
authors: Eeckhout
authors: Sarah
authors: S
authors: De Saeger
authors: Filip
authors: F
authors: Boyen
authors: Bregje
authors: B
authors: Leyman
authors: Alexander
authors: A
authors: Van Parys
authors: Freddy
authors: F
authors: Haesebrouck
authors: Frank
authors: F
authors: Pasmans
mesh_terms: D000327:Adsorption; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002432:Cecum / Q000382:microbiology*; D004032:Diet / Q000662:veterinary; D005506:Food Contamination; D008351:Mannans / Q000737:chemistry*; D009183:Mycotoxins; D012481:Salmonella Infections, Animal / Q000382:microbiology / Q000517:prevention & control; D012486:Salmonella typhimurium / Q000187:drug effects*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D013605:T-2 Toxin / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D008351:Mannans; D009183:Mycotoxins; D013605:T-2 Toxin