title: Magnetic resonance imaging in amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder which is incurable to date. As there are many ongoing studies with therapeutic candidates, it is of major interest to develop biomarkers not only to facilitate early diagnosis but also as a monitoring tool to predict disease progression and to enable correct randomization of patients in clinical trials. Magnetic resonance imaging (MRI) has made substantial progress over the last three decades and is a practical, noninvasive method to gain insights into the pathology of the disease. Disease-specific MRI changes therefore represent potential biomarkers for ALS. In this paper we give an overview of structural and functional MRI alterations in ALS with the focus on task-free resting-state investigations to detect cortical network failures.
authors: Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.
authors: Katja
authors: K
authors: Kollewe
authors: Sonja
authors: S
authors: Körner
authors: Reinhard
authors: R
authors: Dengler
authors: Susanne
authors: S
authors: Petri
authors: Bahram
authors: B
authors: Mohammadi