title: Effect of Renshen polysaccharides on oxidative injury in kidney IR rabbits.
abstract: There is increasing evidence to suggest that reactive oxygen metabolites (ROMs) play a role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to determine the possible protective effect of Renshen polysaccharides (RSP) on renal ischemia/reperfusion (I/R) injury. Results showed that the polysaccharides of Renshen consisted mainly of glucose (29.21%), mannose (6.54%), rhamnose (4.34%), arabose (6.92%), galactose (18.41%). In addition, kidney lipid peroxidation level in IR rabbits were markedly increased, whereas antioxidant enzymes activities were significantly decreased. Renshen polysaccharides pre-treatment could decrease oxidative injury in kidney of IR rabbits.
authors: Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
authors: Zhangshun
authors: Z
authors: Liu
authors: Chao
authors: C
authors: Li
authors: Qin
authors: Q
authors: Zhang
authors: Minfang
authors: M
authors: Tao
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D000818:Animals; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D015427:Reperfusion Injury / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D008315:Malondialdehyde; D005978:Glutathione