title: Sesquiterpenes from the conifer root rot pathogen Heterobasidion occidentale.
abstract: Investigation of the production of secondary metabolites of Heterobasidion occidentale led to the isolation and identification of six sesquiterpenes (illudolone A and B, illudolactone A and B, deoxyfomannosin A and B) along with the well-known sesquiterpene fomannosin and the previously described benzohydrofuran fomannoxin. The structures and relative configurations of the compounds were determined by 1D and 2D NMR spectroscopic analysis as well as by HRMS. Their absolute configuration and biosynthesis were suggested and discussed in relation to fomannosin. Four compounds showed growth inhibiting activity against several basidiomycetes, Phlebiopsis gigantea, Phanerochaete chrysosporium and H. occidentale, and toxicity towards the moss Physcomitrella patens. In addition, one compound displayed activity against the bacterium Variovorax paradoxus as well as against the ascomycete Fusarium oxysporum.
authors: Department of Chemistry, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.
authors: David
authors: D
authors: Hansson
authors: Audrius
authors: A
authors: Menkis
authors: Kajsa
authors: K
authors: Himmelstrand
authors: Mattias
authors: M
authors: Thelander
authors: Ke
authors: K
authors: Olson
authors: Jan
authors: J
authors: Stenlid
authors: Magnus
authors: M
authors: Karlsson
authors: Anders
authors: A
authors: Broberg
mesh_terms: D001487:Basidiomycota / Q000378:metabolism* / Q000502:physiology; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism; D064028:Tracheophyta / Q000382:microbiology*
chemical_list: D012717:Sesquiterpenes