title: Near fatal case of amlodipine poisoning in an infant.
abstract: An 11-mo-old infant received 12.5 times the maximum therapeutic dose of amlodipine as a result of a medication error in lieu of amoxicillin. He presented with vomiting, lethargy, breathlessness, muffled heart sounds and progressed to hypotensive shock within three hours of admission. He received mechanical ventilation, fluid therapy with normal saline and inotropes. But his parameters improved rapidly only after initiating him on insulin and dextrose infusion therapy (for 15 h) along with glucagon and calcium gluconate infusion (for 72 h). Calcium channel blockers (CCB) cause impaired insulin secretion causing hyperglycemia. High levels of blood sugar are of prognostic value rather than hemodynamic variables in CCB poisoning. A continuous infusion of 0.5 to 1 unit per kg body weight per hour of insulin along with supportive therapy including peritoneal dialysis (for deranged renal function) was used with success in managing amlodipine poisoning.
authors: Department of Pediatrics, Shree Krishna Hospital, Pramukhswami Medical College, Karamsad, District, Anand, Gujarat 388325, India. somu_somu@yahoo.com
authors: Somashekhar M
authors: SM
authors: Nimbalkar
authors: Dipen Vasudev
authors: DV
authors: Patel
mesh_terms: D017311:Amlodipine / Q000506:poisoning*; D002121:Calcium Channel Blockers / Q000506:poisoning*; D062787:Drug Overdose / Q000175:diagnosis / Q000188:drug therapy*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007022:Hypotension / Q000188:drug therapy*; D007223:Infant; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008508:Medication Errors
chemical_list: D002121:Calcium Channel Blockers; D007328:Insulin; D017311:Amlodipine; D005947:Glucose