title: Successful desensitization with un-fractionated heparin in a patient with heparin allergy and tolerance to fondaparinux.
abstract: Immediate hypersensitivity to low molecular weight heparin (LMWH) is rare, and we present here a case with an anaphylaxis-like symptoms to enoxaparin. The diagnosis of hypersensitivity to enoxaparin was confirmed by the clinical picture and positive skin tests. In this case, palmo-plantal itching after application of heparin was an early sign of immediate type hypersensitivity. His skin and provocation tests showed cross-reactivity with other types of LMWHs and un-fractionated heparin (UFH). Fondaparinux and desensitization with UFH were found to be safe alternative treatment options in this patient with heparin allergy.
authors: Division of Clinical Immunology and Allergy, Department of Pulmonary Diseases, Erzurum Region Training and Research Hospital, Ministry of Health, Erzurum, Turkey. ayshe_dr@yahoo.com
authors: Ayse Baccioglu
authors: AB
authors: Kavut
authors: Ebru
authors: E
authors: Koca
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods; D004342:Drug Hypersensitivity / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D004361:Drug Tolerance; D017984:Enoxaparin / Q000009:adverse effects*; D000077425:Fondaparinux; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D007108:Immune Tolerance; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D012882:Skin Tests
chemical_list: D017984:Enoxaparin; D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux