title: Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles.
  
  
  OBJECTIVE
  To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing.
  
  
  METHODS
  Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10-500 nm during spontaneous breathing.
  
  
  RESULTS
  The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function.
  
  
  CONCLUSIONS
  The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20-30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease.
authors: Department of Physics, Division of Nuclear Physics, Lund University, Lund, Sweden. jakob.londahl@design.lth.se
authors: Jakob
authors: J
authors: Löndahl
authors: Erik
authors: E
authors: Swietlicki
authors: Jenny
authors: J
authors: Rissler
authors: Agneta
authors: A
authors: Bengtsson
authors: Christoffer
authors: C
authors: Boman
authors: Anders
authors: A
authors: Blomberg
authors: Thomas
authors: T
authors: Sandström
mesh_terms: D000336:Aerosols; D000368:Aged; D001273:Atmosphere Exposure Chambers; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000503:physiopathology; D012123:Pulmonary Ventilation; D020545:Respiratory Mucosa / Q000737:chemistry / Q000378:metabolism*; D012720:Severity of Illness Index; D014018:Tissue Distribution; D001335:Vehicle Emissions
chemical_list: D000336:Aerosols; D052638:Particulate Matter; D001335:Vehicle Emissions