title: Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection.
abstract: OBJECTIVE
  To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
  
  
  METHODS
  This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011.
  
  
  RESULTS
  The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery.
  
  
  CONCLUSIONS
  For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.
authors: School of Medicine, USP, Sao Paulo, Brazil.
authors: Thamirys Guimarães
authors: TG
authors: Marques
authors: Eleazar
authors: E
authors: Chaib
authors: Juliana Hamati
authors: JH
authors: da Fonseca
authors: Ana Cecília Rodrigues
authors: AC
authors: Lourenço
authors: Felipe Duarte
authors: FD
authors: Silva
authors: Marcelo Augusto Fontenelle
authors: MA
authors: Ribeiro
authors: Flavio Henrique Ferreira
authors: FH
authors: Galvão
authors: Luiz Augusto Carneiro
authors: LA
authors: D'Albuquerque
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000601:surgery*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008026:Ligation; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000601:surgery*; D051381:Rats; D013997:Time Factors
chemical_list: D002251:Carbon Tetrachloride