title: Cancer diagnoses after living kidney donation: linking U.S. Registry data and administrative claims.
abstract: BACKGROUND
  Mortality records identify cancer as the leading cause of death among living kidney donors, but information on the burden of cancer outside death records is limited in this population.
  
  
  METHODS
  We examined a database wherein U.S. Organ Procurement and Transplantation Network identifiers for 4,650 living kidney donors in 1987 to 2007 were linked to administrative data of a U.S. private health insurer (2000-2007 claims) to identify postdonation cancer diagnoses. Skin cancer and non-skin cancer diagnoses were ascertained from International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes on billing claims. Donors were also matched one-to-one with general insurance beneficiaries by sex and age when benefits began. Diagnosis rates within observation windows were compared as rate ratios.
  
  
  RESULTS
  The median time from donation to the end of plan insurance enrollment was 7.7 years, with a median observation period of 2.1 years. Skin cancer rates were similar among prior living donors in the observation period and nondonor controls (rate ratio, 0.91; 95% confidence interval [CI], 0.59-1.40). In contrast, the rate of total non-skin cancers was significantly less common among donors than among controls (rate ratio, 0.74; 95% CI, 0.55-0.99), although reduced relative risk was limited to donors captured earlier in relation to donation. Several cases of cancer diagnosis (uterine, melanoma, "other") were identified within the first year after donation. Prostate cancer diagnosis was significantly more common among living donors compared with controls (rate ratio, 3.80; 95% CI, 1.42-10.2).
  
  
  CONCLUSIONS
  Continued study of cancer after kidney donation is warranted to ensure that evaluation, selection, and long-term follow-up support overall good health of the donor.
authors: Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO 63104, USA. lentinek@slu.edu
authors: Krista L
authors: KL
authors: Lentine
authors: Anitha
authors: A
authors: Vijayan
authors: Huiling
authors: H
authors: Xiao
authors: Mark A
authors: MA
authors: Schnitzler
authors: Connie L
authors: CL
authors: Davis
authors: Amit X
authors: AX
authors: Garg
authors: David
authors: D
authors: Axelrod
authors: Kevin C
authors: KC
authors: Abbott
authors: Daniel C
authors: DC
authors: Brennan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011471:Prostatic Neoplasms / Q000453:epidemiology; D012042:Registries; D012878:Skin Neoplasms / Q000453:epidemiology; D014481:United States