title: Modified autologous matrix-induced chondrogenesis (AMIC) for the treatment of a large osteochondral defect in a varus knee: a case report.
abstract: This paper presents a case report of a 27-year-old male patient affected by a large osteochondral defect of the medial femoral condyle (6 cm(2)) in a varus knee. He was treated with a combined approach consisting of high tibial osteotomy and autologous matrix-induced chondrogenesis technique enhanced by a bone marrow-enriched bone graft. Twelve months after surgery, the patient reported considerable reduction in pain and significant increase in his quality of life. A hyaline-like cartilage completely covered the defect and was congruent with the surrounding condyle cartilage as revealed by MRI and by a second-look arthroscopy.                  Level of evidence IV.
authors: Orthopaedic Biotechnologies Lab, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
authors: L
authors: L
authors: de Girolamo
authors: A
authors: A
authors: Quaglia
authors: C
authors: C
authors: Bait
authors: M
authors: M
authors: Cervellin
authors: E
authors: E
authors: Prospero
authors: P
authors: P
authors: Volpi
mesh_terms: D000328:Adult; D000818:Animals; D001182:Arthroscopy; D060750:Bone Anteversion / Q000503:physiopathology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D018786:Bone Substitutes; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery*; D002417:Cattle; D002478:Cells, Cultured; D020219:Chondrogenesis; D024042:Collagen Type I / Q000008:administration & dosage; D024061:Collagen Type III / Q000008:administration & dosage; D005269:Femur / Q000293:injuries / Q000601:surgery*; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D010027:Osteotomy; D010147:Pain Measurement; D013552:Swine; D013977:Tibia / Q000601:surgery
chemical_list: D018786:Bone Substitutes; D024042:Collagen Type I; D024061:Collagen Type III