title: Sex steroid hormone effects in normal and pathologic conditions in lung physiology.
abstract: Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
authors: Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México, D.F., México. alieshagonzalez@gmail.com
authors: A
authors: A
authors: González-Arenas
authors: J
authors: J
authors: Agramonte-Hevia
mesh_terms: D000818:Animals; D001249:Asthma / Q000378:metabolism* / Q000473:pathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D018192:Lymphangioleiomyomatosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D012739:Gonadal Steroid Hormones