title: [Endophenotypes in schizophrenia: a review of electrophysiological studies].
abstract: Schizophrenia patients consistently show some deficiency in electrophysiological measures, such as PPI (Prepulse Inhibition), ERP (Event-Related Potential) components (mismatch negativity, P50, P300), EEG (Electroencephalography), and MEG (Magnetoencephalography). These components have been intensively studied as quantitative biological markers (i.e., endophenotypes) for psychiatric disorders. Recently brain oscillations, especially gamma (30-80 Hz) band activity (GBA), are being increasingly investigated as new candidate endophenotypes. In this review, we summarize the current status, perspective, and limitations of representative paradigms for investigating abnormal electrophysiological components of schizophrenia, along with relevant genetic polymorphism.
authors: Department of Psychiatry, Osaka University Graduate School of Medicine.
authors: Ryouhei
authors: R
authors: Ishii
authors: Hidetoshi
authors: H
authors: Takahashi
authors: Ryu
authors: R
authors: Kurimoto
authors: Yasunori
authors: Y
authors: Aoki
authors: Shunichiro
authors: S
authors: Ikeda
authors: Masahiro
authors: M
authors: Hata
authors: Koji
authors: K
authors: Ikezawa
authors: Leonides
authors: L
authors: Canuet
authors: Takayuki
authors: T
authors: Nakahachi
authors: Masao
authors: M
authors: Iwase
authors: Masatoshi
authors: M
authors: Takeda
mesh_terms: D004569:Electroencephalography; D055724:Electrophysiological Phenomena; D058068:Endophenotypes; D005071:Evoked Potentials / Q000235:genetics / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*