title: Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies.
abstract: OBJECTIVE
  To quantify the link between lower, subclinically symptomatic, levels of psychological distress and cause-specific mortality in a large scale, population based study.
  
  
  METHODS
  Individual participant meta-analysis of 10 large prospective cohort studies from the Health Survey for England. Baseline psychological distress measured by the 12 item General Health Questionnaire score, and mortality from death certification.
  
  
  METHODS
  68,222 people from general population samples of adults aged 35 years and over, free of cardiovascular disease and cancer, and living in private households in England at study baseline.
  
  
  METHODS
  Death from all causes (n = 8365), cardiovascular disease including cerebrovascular disease (n = 3382), all cancers (n = 2552), and deaths from external causes (n = 386). Mean follow-up was 8.2 years (standard deviation 3.5).
  
  
  RESULTS
  We found a dose-response association between psychological distress across the full range of severity and an increased risk of mortality (age and sex adjusted hazard ratio for General Health Questionnaire scores of 1-3 v score 0: 1.20, 95% confidence interval 1.13 to 1.27; scores 4-6: 1.43, 1.31 to 1.56; and scores 7-12: 1.94, 1.66 to 2.26; P<0.001 for trend). This association remained after adjustment for somatic comorbidity plus behavioural and socioeconomic factors. A similar association was found for cardiovascular disease deaths and deaths from external causes. Cancer death was only associated with psychological distress at higher levels.
  
  
  CONCLUSIONS
  Psychological distress is associated with increased risk of mortality from several major causes in a dose-response pattern. Risk of mortality was raised even at lower levels of distress.
authors: Scottish Dementia Clinical Research Network, NHS Scotland, Murray Royal Hospital, Perth, UK. tom.russ@nhs.net
authors: Tom C
authors: TC
authors: Russ
authors: Emmanuel
authors: E
authors: Stamatakis
authors: Mark
authors: M
authors: Hamer
authors: John M
authors: JM
authors: Starr
authors: Mika
authors: M
authors: Kivimäki
authors: G David
authors: GD
authors: Batty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D004739:England / Q000453:epidemiology; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013315:Stress, Psychological / Q000401:mortality*; D011795:Surveys and Questionnaires