title: [Advance of the research for disease-responsible genes].
abstract: Over the last three decades, many disease-responsible genes have been identified due to advancement of technologies in molecular biology. Methodologies to identify disease-responsible genes have been changed according to the history. Although large subject numbers were needed previously, valuable data derived from only one rare patient have led to identify some disease-responsible genes. Recently launched next-generation sequencers have heralded the new personal genome era. We should know that we may be able to identify some disease-responsible genes by the investigation of only one patient who we meet at the bed side.
authors: Tokyo Women's Medical University, Institute for Integrated Medical Sciences, Tokyo. yamamoto.toshiyuki@twmu.ac.jp
authors: Toshiyuki
authors: T
authors: Yamamoto
mesh_terms: D003001:Cloning, Molecular; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods*