title: In silico study of Alzheimer's disease in relation to FYN gene.
abstract: To understand the role of FYN (Fibroblast Yes related novel) gene products in relation to neurodegeneration and Alzheimer's disease we have analyzed the SNPs (single nucleotide polymorphism) associated with this gene. This can help us to understand the genetic variations that can alter the function of the gene products. A total of 3463 SNPs are investigated for FYN. To determine whether a non-synonymous SNP (nsSNP) in this gene affects its protein product, we used certain computational tools which predicted two nsSNPs (rs1801109, rs1801121) to have significant damaging effects. The amino acid change for rs1801109 is from alanine to aspartate, i.e. from a neutral, non-polar amino acid to a polar, acidic amino acid (electrically charged) and for rs1801121 it is from isoleucine to phenylalanine, i.e. from an aliphatic, hydrophobic molecule to an aromatic, highly hydrophobic residue. Hence, due to the complete change in charges and side chains of the amino acid residues brought about by these nsSNPs, respectively, might affect the structure and function of the protein. The results presented from this in silico study will open up new prospect for genetic analysis of FYN gene and their correlation with clinical data will be very useful in understanding the genetics of Alzheimer's disease.
authors: Bioinformatics Division, School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India. aanand@vit.ac.in
authors: Anand
authors: A
authors: Anbarasu
authors: Arpita
authors: A
authors: Kundu
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D019943:Amino Acid Substitution / Q000235:genetics; D000596:Amino Acids / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D017124:Conserved Sequence; D030541:Databases, Genetic; D006801:Humans; D008958:Models, Molecular; D050505:Mutant Proteins / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051076:Proto-Oncogene Proteins c-fyn / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D000596:Amino Acids; D050505:Mutant Proteins; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn