title: Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex.
abstract: Fenproporex is an amphetamine-based anorectic and it is rapidly converted in vivo into amphetamine. It elevates the levels of extracellular dopamine in the brain. Acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine. Thus, we investigated whether the effects of chronic administration of fenproporex in adult rats alters acquisition and retention of avoidance memory and acetylcholinesterase activity. Adult male Wistar rats received repeated (14 days) intraperitoneal injection of vehicle or fenproporex (6.25, 12.5 or 25 mg/kg i.p.). For behavioral assessment, animals were submitted to inhibitory avoidance (IA) tasks and continuous multiple trials step-down inhibitory avoidance (CMIA). Acetylcholinesterase activity was measured in the prefrontal cortex, hippocampus, hypothalamus and striatum. The administration of fenproporex (6.25, 12.5 and 25 mg/kg) did not induce impairment in short and long-term IA or CMIA retention memory in rats. In addition, longer periods of exposure to fenproporex administration decreased acetylcholinesterase activity in prefrontal cortex and striatum of rats, but no alteration was verified in the hippocampus and hypothalamus. In conclusion, the present study showed that chronic fenproporex administration decreased acetylcholinesterase activity in the rat brain. However, longer periods of exposure to fenproporex did not produce impairment in short and long-term IA or CMIA retention memory in rats.
authors: Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, Criciúma, 88806-000, SC, Brazil.
authors: Gislaine T
authors: GT
authors: Rezin
authors: Giselli
authors: G
authors: Scaini
authors: Gabriela K
authors: GK
authors: Ferreira
authors: Mariane R
authors: MR
authors: Cardoso
authors: Cinara L
authors: CL
authors: Gonçalves
authors: Larissa S
authors: LS
authors: Constantino
authors: Pedro F
authors: PF
authors: Deroza
authors: Fernando V
authors: FV
authors: Ghedim
authors: Samira S
authors: SS
authors: Valvassori
authors: Wilson R
authors: WR
authors: Resende
authors: João
authors: J
authors: Quevedo
authors: Alexandra I
authors: AI
authors: Zugno
authors: Emilio L
authors: EL
authors: Streck
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002800:Cholinesterase Inhibitors; D004305:Dose-Response Relationship, Drug; D007527:Isoenzymes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000662:Amphetamines; D001067:Appetite Depressants; D002800:Cholinesterase Inhibitors; D007527:Isoenzymes; D000110:Acetylcholinesterase; C026013:fenproporex