title: A catalytic asymmetric ring-expansion reaction of isatins and α-alkyl-α-diazoesters: highly efficient synthesis of functionalized 2-quinolone derivatives.
abstract: Asymmetric expansion: A catalytic asymmetric ring-expansion reaction of the title compounds occurs in the presence of a Sc(OTf)(3)  catalyst bearing an N,N'-dioxide-based ligand. Highly functionalized 2-quinolone derivatives containing a chiral C4-quaternary stereocenter were obtained in high yields and high levels of selectivity under mild reaction conditions (see scheme; Tf=trifluoromethanesulfonyl).
authors: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
authors: Wei
authors: W
authors: Li
authors: Xiaohua
authors: X
authors: Liu
authors: Xiaoyu
authors: X
authors: Hao
authors: Yunfei
authors: Y
authors: Cai
authors: Lili
authors: L
authors: Lin
authors: Xiaoming
authors: X
authors: Feng
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D012538:Scandium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; D004952:Esters; D011804:Quinolines; D007510:Isatin; D012538:Scandium