title: Pharmacokinetics of amphotericin B colloidal dispersion in critically ill patients with cholestatic liver disease.
abstract: The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposure to lipid-bound AMB was higher in patients with CSLD. Levels of liberated AMB were elevated by CSLD only after the first dose, whereas its pharmacokinetics was unaffected at steady state. The standard dosage of ABCD is probably adequate for patients with CSLD.
authors: Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria.
authors: Stefan
authors: S
authors: Weiler
authors: Elisabeth
authors: E
authors: Überlacher
authors: Julia
authors: J
authors: Schöfmann
authors: Eva
authors: E
authors: Stienecke
authors: Stefan
authors: S
authors: Dunzendorfer
authors: Michael
authors: M
authors: Joannidis
authors: Romuald
authors: R
authors: Bellmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000097:blood / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D003102:Colloids; D016638:Critical Illness; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D003102:Colloids; D000666:Amphotericin B