title: Low incidence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly in Tianjin, northern China.
abstract: The purpose of this study was to examine the incidence of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly in a representative northern Chinese population. Overall, 212 cases of primary diffuse large B-cell lymphoma were analyzed for EBV-positive status by detection of EBV-encoded RNA using in situ hybridization. Immunophenotypic identity was verified by a streptavidin-biotin peroxidase detection system using the markers CD20, CD3, CD10, BCL6 and MUM1. The prevalence of EBV-positive diffuse large B-cell lymphoma in elderly northern Chinese patients was 3.8% (eight of 212). All eight cases were negative for CD10 and BCL6 immunostaining. The incidence is less frequent than that of southern China and other East-Asian countries. Patients tend to be older, present with a non-germinal center B-cell-like immunophenotype and have a poor outcome.
authors: Tianjin Medical University Cancer Institute and Hospital and Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
authors: Yi
authors: Y
authors: Pan
authors: Bin
authors: B
authors: Meng
authors: Huilai
authors: H
authors: Zhang
authors: Wenfeng
authors: W
authors: Cao
authors: Huaqing
authors: H
authors: Wang
authors: Chengfeng
authors: C
authors: Bi
authors: Fujin
authors: F
authors: Liu
authors: Baocun
authors: B
authors: Sun
authors: Xishan
authors: X
authors: Hao
authors: Weiyun Z
authors: WZ
authors: Ai
authors: Kai
authors: K
authors: Fu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D015994:Incidence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D055815:Young Adult