title: Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.
abstract: OBJECTIVE
  The beta cell transcriptional factor musculoaponeurotic fibrosarcoma oncogene family A (MafA) regulates genes important for beta cell function. Loss of nuclear MafA has been implicated in beta cell dysfunction in animal models of type 2 diabetes. We sought to establish if nuclear MafA is less abundant in beta cell nuclei in humans with type 2 diabetes.
  
  
  METHODS
  Pancreas obtained at surgery from five non-diabetic individuals and six individuals with type 2 diabetes was immunostained for insulin, glucagon and MafA.
  
  
  RESULTS
  Beta cell nuclear MafA was markedly decreased in type 2 diabetes (1.6 ± 1.2% vs 46.3 ± 8.3%, p < 0.001).
  
  
  CONCLUSIONS
  Beta cell nuclear MafA is markedly decreased in humans with type 2 diabetes, which may contribute to impaired beta cell dysfunction.
authors: Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900 Veteran Avenue, 24-130 Warren Hall, Los Angeles, CA 90095-7073, USA.
authors: A E
authors: AE
authors: Butler
authors: R P
authors: RP
authors: Robertson
authors: R
authors: R
authors: Hernandez
authors: A V
authors: AV
authors: Matveyenko
authors: T
authors: T
authors: Gurlo
authors: P C
authors: PC
authors: Butler
mesh_terms: D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000502:physiology*; D051473:Maf Transcription Factors, Large / Q000172:deficiency* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D051381:Rats; D011923:Rats, Nude
chemical_list: D001786:Blood Glucose; D007328:Insulin; C485159:MAFA protein, human; D051473:Maf Transcription Factors, Large; D005934:Glucagon