title: Triple receptor-negative breast cancer: imaging and clinical characteristics.
abstract: OBJECTIVE
  The objective of our study was to retrospectively evaluate the imaging findings of patients with breast cancer negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)-so-called "triple receptor-negative cancer"-and to compare the mammographic findings and clinical characteristics of triple receptor-negative cancer with non-triple receptor-negative cancers (i.e., ER-positive, PR-positive, or HER2-positive or two of the three markers positive).
  
  
  CONCLUSIONS
  Triple receptor-negative cancer was most commonly an irregular noncalcified mass with ill-defined or spiculated margins on mammography and a hypoechoic or complex mass with an irregular shape and noncircumscribed margins on ultrasound. Most triple receptor-negative cancers were discovered on physical examination. Compared with non-triple receptor-negative cancers, triple receptor-negative cancers were found in younger women and were a higher pathologic grade.
authors: Department of Radiology, Regional Medical Imaging, 3346 Lennon Rd., Flint, MI 48507, USA.
authors: Kristin M
authors: KM
authors: Krizmanich-Conniff
authors: Chintana
authors: C
authors: Paramagul
authors: Stephanie K
authors: SK
authors: Patterson
authors: Mark A
authors: MA
authors: Helvie
authors: Marilyn A
authors: MA
authors: Roubidoux
authors: Jamie D
authors: JD
authors: Myles
authors: Kiting
authors: K
authors: Jiang
authors: Michael
authors: M
authors: Sabel
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D016015:Logistic Models; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D016217:Ultrasonography, Mammary
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone