title: [Effects of mexidol and sulodexide on the level of specific markers of endothelial dysfunction in animals with experimental diabetes mellitus].
abstract: Streptozotocin-induced diabetes leads to the development of endothelial dysfunction, as evidenced by decreased expression of endothelial nitric oxide synthase (eNOS) and increased expression of endothelin-1 as specific markers of endothelial disorders. All test substances showed endotelioprotective activity by increasing the concentration of eNOS and reducing the level of endothelin-1. With respect to the degree of impact on the eNOS and endothelin-1 levels, the compounds studied can be rated as follows: sulodexide > meksidol.
authors: I N
authors: IN
authors: Tiurenkov
authors: A V
authors: AV
authors: Voronkov
authors: A A
authors: AA
authors: Slietsans
authors: G L
authors: GL
authors: Snigur
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism; D019332:Endothelin-1 / Q000276:immunology / Q000378:metabolism*; D004727:Endothelium / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006025:Glycosaminoglycans / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000276:immunology / Q000378:metabolism*; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D014652:Vascular Diseases / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019332:Endothelin-1; D006025:Glycosaminoglycans; D010847:Picolines; C070020:emoxypine succinate; C007858:glucuronyl glucosamine glycan sulfate; D052250:Nitric Oxide Synthase Type III