title: A functional framework for interpretation of genetic associations in T1D.
abstract: Susceptibility to type 1 diabetes is attributable to genes that link disease progression to distinct steps in immune activation, expansion, and regulation. Recent studies illustrate examples of disease-associated variants that function in multiple cell types and independent pathways, some that impact different steps of a single mechanistic pathway, and some that are functionally interactive for deterministic events in setting thresholds for immune response.
authors: Benaroya Research Institute and the University of Washington School of Medicine, Seattle, WA, United States. jnepom@benaroyaresearch.org
authors: Gerald T
authors: GT
authors: Nepom
authors: Jane H
authors: JH
authors: Buckner
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D056726:Genetic Association Studies / Q000379:methods* / Q000639:trends; D014644:Genetic Variation / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D007111:Immunity, Cellular / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology