title: Target molecular simulations of RecA family protein filaments.
abstract: Modeling of the RadA family mechanism is crucial to understanding the DNA SOS repair process. In a 2007 report, the archaeal RadA proteins function as rotary motors (linker region: I71-K88) such as shown in Figure 1. Molecular simulations approaches help to shed further light onto this phenomenon. We find 11 rotary residues (R72, T75-K81, M84, V86 and K87) and five zero rotary residues (I71, K74, E82, R83 and K88) in the simulations. Inclusion of our simulations may help to understand the RadA family mechanism.
authors: Department of Information Management, Chia Nan University of Pharmacy & Science, No. 60, Sec. 1, Erren Rd., Rende Dist., Tainan City 71710, Taiwan.
authors: Zhi-Yuan
authors: ZY
authors: Su
authors: National Center for High-Performance Computing, Hsin-Shi, No. 28, Nan-Ke 3rd Rd., Hsin-Shi Dist., Tainan City 74147, Taiwan.
authors: Wen-Jay
authors: WJ
authors: Lee
authors: National Center for High-Performance Computing, Hsin-Shi, No. 28, Nan-Ke 3rd Rd., Hsin-Shi Dist., Tainan City 74147, Taiwan.|Department of Physics, National Chung Hsing University, No. 250, Kuo Kuang Rd., Taichung 402, Taiwan.
authors: Wan-Sheng
authors: WS
authors: Su
authors: National Center for High-Performance Computing, Hsin-Shi, No. 28, Nan-Ke 3rd Rd., Hsin-Shi Dist., Tainan City 74147, Taiwan.
authors: Yeng-Tseng
authors: YT
authors: Wang
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000465:Algorithms; D000595:Amino Acid Sequence; D019843:Archaeal Proteins / Q000737:chemistry*; D003198:Computer Simulation; D003599:Cytoskeleton / Q000378:metabolism; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011938:Rec A Recombinases / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
chemical_list: D019843:Archaeal Proteins; D004268:DNA-Binding Proteins; C117252:RadA protein, archaeal; D000255:Adenosine Triphosphate; D011938:Rec A Recombinases