title: Chronic graft-versus-host disease after liver transplantation: a case report.
abstract: Graft-versus-host disease (GVHD) after orthotopic liver transplantation (OLT) is a rare but significant complication, occurring in 1%-2% of cases with a mortality rate of 85%- 90%. It occurs when donor passenger lymphocytes mount an alloreactive response against the host's histocompatibility antigens. It presents as fever, rash, and diarrhea with or without pancytopenia. Between March 2002 and September 2011, among 656 OLT patients 1 (0.15%) had acute GVHD. A biopsy at the 7th posttransplantation month revealed chronic GVHD. Consequently, in the cases that had fever, rash, and/or desquamation of the any part of body after liver transplantation, GVHD must be considered and skin biopsies must be planned for the diagnosis.
authors: Department of Surgery, Division of Liver Traansplantation, Inonu University Faculty of Medicine, Malatya, Turkey. mehmet.yilmaz@inonu.edu.tr
authors: M
authors: M
authors: Yilmaz
authors: F
authors: F
authors: Ozdemir
authors: S
authors: S
authors: Akbulut
authors: V
authors: V
authors: Ersan
authors: C
authors: C
authors: Koc
authors: S
authors: S
authors: Koc
authors: S
authors: S
authors: Yilmaz
mesh_terms: D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000821:virology; D002908:Chronic Disease; D005076:Exanthema / Q000175:diagnosis / Q000276:immunology; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008103:Liver Cirrhosis / Q000821:virology; D008113:Liver Neoplasms / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents