title: A general method for palladium-catalyzed direct carbonylation of indole with alcohol and phenol.
abstract: A novel strategy involving a first oxidative iodination and subsequent Pd(0)-catalyzed carbonylation to yield indole-3-carboxylate has been developed. It showed perfect generality to indole, alcohol, and phenol. The current methodology could also be conveniently applied to the synthesis of biologically active tropisetron from simple indole and tropine.
authors: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors: Rui
authors: R
authors: Lang
authors: Lijun
authors: L
authors: Shi
authors: Dengfeng
authors: D
authors: Li
authors: Chungu
authors: C
authors: Xia
authors: Fuwei
authors: F
authors: Li
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D000077526:Tropisetron
chemical_list: D000438:Alcohols; D007211:Indoles; D010636:Phenols; D010165:Palladium; D000077526:Tropisetron