title: [Effect of estradiol on food intake, glucose and fat metabolism in mice C57BL/6J with mutation yellow at the agouti locus].
abstract: Mutation yellow at the agouti locus in mice (A(y)/a-mice) causes the increase of food intake and development of obesity and type 2 diabetes. In A(y)/a-females the disturbances of glucose and fat metabolisms occur after puberty. We have assumed that the mutation yellow violates the regulatory effect of estradiol on glucose and fat metabolism in mice. We investigated the effects of ovariectomy and estradiol treatment on body weight, food intake, glucose tolerance, plasma levels of glucose, insulin and etherified fatty acids in A(y)/a-females. C57Bl/6J females, not carrying yellow mutation at the agouti locus (a/a-mice), were used as a control. The data suggest that the yellow mutation did not affect estradiol regulation of food intake and glucose blood levels after a night of fasting, but, apparently, prevented estradiol participation in the regulation of glucose and fat metabolisms in the muscle and fat tissues.
authors: T V
authors: TV
authors: Iakovleva
authors: E N
authors: EN
authors: Makarova
authors: A Iu
authors: AIu
authors: Kazantseva
authors: N M
authors: NM
authors: Bazhan
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D054366:Agouti Signaling Protein / Q000235:genetics*; D000818:Animals; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D004435:Eating / Q000187:drug effects* / Q000235:genetics; D004958:Estradiol / Q000008:administration & dosage*; D005215:Fasting; D005260:Female; D005947:Glucose / Q000235:genetics / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009154:Mutation; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000378:metabolism
chemical_list: D054366:Agouti Signaling Protein; D007328:Insulin; C515183:a protein, mouse; D004958:Estradiol; D005947:Glucose