title: Calcium channels and pumps in cancer: changes and consequences.
abstract: Increases in intracellular free Ca(2+) play a major role in many cellular processes. The deregulation of Ca(2+) signaling is a feature of a variety of diseases, and modulators of Ca(2+) signaling are used to treat conditions as diverse as hypertension to pain. The Ca(2+) signal also plays a role in processes important in cancer, such as proliferation and migration. Many studies in cancer have identified alterations in the expression of proteins involved in the movement of Ca(2+) across the plasma membrane and subcellular organelles. In some cases, these Ca(2+) channels or pumps are potential therapeutic targets for specific cancer subtypes or correlate with prognosis.
authors: School of Pharmacy, The University of Queensland, Brisbane 4075, Australia. gregm@uq.edu.au
authors: Gregory R
authors: GR
authors: Monteith
authors: Felicity M
authors: FM
authors: Davis
authors: Sarah J
authors: SJ
authors: Roberts-Thomson
mesh_terms: D000818:Animals; D017209:Apoptosis; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D011379:Prognosis
chemical_list: D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium