title: Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis.
abstract: The cellular and molecular mechanisms that control lung homeostasis and regeneration are still poorly understood. It has been proposed that a population of cells exists in the mouse lung with the potential to differentiate into all major lung bronchioalveolar epithelium cell types in homeostasis or in response to virus infection. A new population of E-Cad/Lgr6(+) putative stem cells has been isolated, and indefinitely expanded from human lungs, harbouring both, self-renewal capacity and the potency to differentiate in vitro and in vivo. Recently, a putative population of human lung stem cells has been proposed as being c-Kit(+). Unlike Integrin-α6(+) or c-Kit(+) cells, E-Cad/Lgr6(+) single-cell injections in the kidney capsule produce differentiated bronchioalveolar tissue, while retaining self-renewal, as they can undergo serial transplantations under the kidney capsule or in the lung. In addition, a signalling network involving the p38α pathway, the activation of p53 and the regulation of the miR-17-92 cluster has been identified. Disruption of the proper cross-regulation of this signalling axis might be involved in the promotion of human lung diseases.
authors: CSCR (Wellcome Trust Centre for Stem Cell Research), Cambridge, UK.
authors: Feride
authors: F
authors: Oeztuerk-Winder
authors: Anna
authors: A
authors: Guinot
authors: Anna
authors: A
authors: Ochalek
authors: Juan-Jose
authors: JJ
authors: Ventura
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008168:Lung / Q000166:cytology*; D035683:MicroRNAs / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: C524941:MIRN17 microRNA, human; C549214:MIRN19A microRNA, human; D035683:MicroRNAs; D048051:p38 Mitogen-Activated Protein Kinases