title: Sugar, sex, and TGF-β in diabetic nephropathy.
abstract: TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.
authors: Center for Renal Translational Medicine, University of California San Diego/Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093-0711, USA.
authors: Maggie K
authors: MK
authors: Diamond-Stanic
authors: Young H
authors: YH
authors: You
authors: Kumar
authors: K
authors: Sharma
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D003928:Diabetic Nephropathies / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D012737:Sex Factors; D015398:Signal Transduction; D051247:Sodium-Glucose Transport Proteins / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D051247:Sodium-Glucose Transport Proteins; D016212:Transforming Growth Factor beta; D013739:Testosterone; D004958:Estradiol; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose