title: Photobiocatalyzed asymmetric reduction of ketones using Chlorella sp. MK201.
abstract: Aromatic ketones were reduced using suspension culture of Chlorella sp. MK201 under fluorescent light illumination producing the corresponding chiral alcohols in high yields with excellent enantiomeric excess (ee). For example, 2',3',4',5',6'-pentafluoroacetophenone at 0.25 mg/ml was converted to the corresponding (S)-alcohol in 80 % yield with >99 % ee by 1 mg dry wt of Chlorella/ml in 12 h illumination (2,000 lux).
authors: Department of Liberal Arts and Science, College of Science and Technology, Nihon University, 7-24-1 Narashinodai, Funabashi-shi, Chiba, Japan. k-itoh@chem.ge.cst.nihon-u.ac.jp
authors: Ken-ichi
authors: K
authors: Itoh
authors: Kaoru
authors: K
authors: Nakamura
authors: Tadashi
authors: T
authors: Aoyama
authors: Ryusuke
authors: R
authors: Matsuba
authors: Tsuyoshi
authors: T
authors: Kakimoto
authors: Masahiko
authors: M
authors: Murakami
authors: Rio
authors: R
authors: Yamanaka
authors: Toshiya
authors: T
authors: Muranaka
authors: Hiroshi
authors: H
authors: Sakamaki
authors: Toshio
authors: T
authors: Takido
mesh_terms: D000438:Alcohols / Q000737:chemistry / Q000378:metabolism; D002708:Chlorella / Q000378:metabolism*; D005453:Fluorescence; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones