title: Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium?
abstract: OBJECTIVE
  We sought to determine the prevalence of adenomyosis and assess its effect on lymph node status in endometrioid adenocarcinoma of the endometrium (EAC).
  
  
  METHODS
  Hysterectomy specimens from a single institution were reviewed for the presence of adenomyosis, lymphovascular space invasion (LVSI), tumor grade, histology, and lymph node status. Standard statistical analysis was used to compare variables.
  
  
  RESULTS
  Adenomyosis was present in 42% of total and 66% of malignant hysterectomy specimens (P = .009). Adenomyosis was most commonly associated with EAC histology (P = .023). LVSI was found to be an independent predictor of lymph node metastasis in EAC patients without adenomyosis, but not in those with coexisting adenomyosis (odds ratio, 58.7; P = .03; and odds ratio, 4.98; P = .15; respectively).
  
  
  CONCLUSIONS
  Adenomyosis was associated with a lower risk of lymph node metastasis in EAC patients with LVSI. Further studies are needed to investigate the role of adenomyosis in lymphatic tumor infiltration.
authors: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY, USA.
authors: Fernanda
authors: F
authors: Musa
authors: Melissa K
authors: MK
authors: Frey
authors: H Beatrice
authors: HB
authors: Im
authors: Marina
authors: M
authors: Chekmareva
authors: Lora H
authors: LH
authors: Ellenson
authors: Kevin
authors: K
authors: Holcomb
mesh_terms: D062788:Adenomyosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome