title: A thrombus susceptibility comparison of two pulsatile Penn State 50 cc left ventricular assist device designs.
abstract: Left ventricular assist devices (LVADs) have proven successful as bridge to transplant devices for patients awaiting donor organs. While survival rates continue to increase, destination therapy remains hindered by thrombus formation within the device. Research has shown that thrombosis is correlated to the fluid dynamics within the device and may be a result of sustained shear rates below 500 s(-1) on the polyurethane blood sac used in the Penn State pulsatile LVAD. Particle image velocimetry is used to compare flow within two 50 cc LVAD designs to assess fluid patterns and quantify wall shear rates in regions known from in vivo studies to be susceptible to thrombus formation. The two designs differ in their front face geometry. The V-1 model has an outward-facing "dome" whereas the face of the V-2 model is flat. A thrombus susceptibility metric, which uses measured wall shear rates and exposure times, was applied to objectively compare pump designs over the entire cardiac cycle. For each design, there are regions where wall shear rates remained below 500 s(-1) for the entire cardiac cycle resulting in high thrombus susceptibility potential. Results of this study indicate that the V-2 device had an overall lower propensity for thrombus formation in the current region of interest.
authors: Department of Bioengineering, The Pennsylvania State University, 205 Hallowell Building, University Park, PA 16802, USA.
authors: Michael A
authors: MA
authors: Navitsky
authors: Steven
authors: S
authors: Deutsch
authors: Keefe B
authors: KB
authors: Manning
mesh_terms: D004867:Equipment Design; D006352:Heart Ventricles; D006353:Heart-Assist Devices / Q000009:adverse effects*; D057446:Hydrodynamics; D011673:Pulsatile Flow; D013927:Thrombosis / Q000209:etiology*