title: HPV infection in Brazilian patients with esophageal squamous cell carcinoma: interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters.
abstract: The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence of HPV in 264 ESCC samples from Brazil, and correlated it with the presence of surrogate markers and clinicopathological characteristics. HPV is present in 13% of ESCC, and with a 3-fold variation between high and medium incidence areas. Most HPV positive tumors were infected with HPV16, but this was not associated with p16 expression, TP53 mutation status, patient age, amount of tobacco or alcohol consumption, or overall survival. We conclude that HPV infection may not have a role in ESCC.
authors: Programa de Mecanismos de Carcinogênese Molecular, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
authors: Suellen
authors: S
authors: Herbster
authors: Cintia Tereza Lima
authors: CT
authors: Ferraro
authors: Natália Kirsch
authors: NK
authors: Koff
authors: Ana
authors: A
authors: Rossini
authors: Cleber Dario Pinto
authors: CD
authors: Kruel
authors: Nelson Adami
authors: NA
authors: Andreollo
authors: Davy Carlos Mendes
authors: DC
authors: Rapozo
authors: Tânia Cristina Moita
authors: TC
authors: Blanco
authors: Paulo Antonio Silvestre de
authors: PA
authors: Faria
authors: Paulo Thiago de Souza
authors: PT
authors: Santos
authors: Rodolpho Matos
authors: RM
authors: Albano
authors: Tatiana de Almeida
authors: Tde A
authors: Simão
authors: Luis Felipe Ribeiro
authors: LF
authors: Pinto
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000821:virology*; D004938:Esophageal Neoplasms / Q000235:genetics / Q000821:virology*; D005260:Female; D019942:Genes, p16; D016158:Genes, p53; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D030361:Papillomavirus Infections / Q000150:complications*; D015995:Prevalence; D012907:Smoking