title: MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine.
abstract: The inclusion of a potent TLR4 immune potentiator to a recombinant antigen vaccine formulation enhances both the magnitude and the breadth of the engendered immune response. One such immune potentiator (TLR4 agonist E6020) was evaluated with recombinant Men B antigens delivered in MF59 sub-micron adjuvant emulsion. The ability of this formulation to enhance serum antibody and bactercidal titers was investigated. The co-delivery of E6020 within MF59 enhanced both the serum and bactericidal titers for Men B antigens and for Men B antigens combined with Men ACWY-CRM conjugate vaccine. The delivery of TLR4 agonist within MF59 emulsion oil droplets leads to a more potent response in comparison to the TLR4 when admixed with MF59 emulsion.
authors: Novartis Vaccines, Cambridge, MA, USA. manmohan.singh@novartis.com
authors: Manmohan
authors: M
authors: Singh
authors: Jina
authors: J
authors: Kazzaz
authors: Mildred
authors: M
authors: Ugozzoli
authors: Barbara
authors: B
authors: Baudner
authors: Mariagrazia
authors: M
authors: Pizza
authors: Marzia
authors: M
authors: Giuliani
authors: Lynn D
authors: LD
authors: Hawkins
authors: Gillis
authors: G
authors: Otten
authors: Derek T
authors: DT
authors: O'Hagan
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001770:Blood Bactericidal Activity; D005260:Female; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D051379:Mice; D011136:Polysorbates / Q000008:administration & dosage*; D013185:Squalene / Q000008:administration & dosage*; D051197:Toll-Like Receptor 4 / Q000819:agonists*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; C089950:MF59 oil emulsion; D022401:Meningococcal Vaccines; D011136:Polysorbates; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D014614:Vaccines, Synthetic; D013185:Squalene