title: [Recognition of commensal microflora by pattern recognition receptors in human physiology and pathology].
abstract: Contemporary data on the interaction of commensal microflora and Toll-like pattern recognition receptors are presented. These receptors recognize normal intestine microflora in physiological conditions, and this interaction is necessary for the maintenance of homeostasis and damage reparation of the intestine, for the induction of heat shock cytoprotective proteins. As a side effect in disruption of immunologic tolerance and misbalance of protective immunological mechanisms, multiorgan pathologic changes of organs and tissues may develop, including chronic inflammation processes of various localization.
authors: V M
authors: VM
authors: Bondarenko
authors: V G
authors: VG
authors: Likhoded
mesh_terms: D004755:Enterobacteriaceae / Q000502:physiology; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D013559:Symbiosis; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D006360:Heat-Shock Proteins; D051193:Toll-Like Receptors