title: Research opportunities for cancer associated with indoor air pollution from solid-fuel combustion.
abstract: BACKGROUND
  Indoor air pollution (IAP) derived largely from the use of solid fuels for cooking and heating affects about 3 billion people worldwide, resulting in substantial adverse health outcomes, including cancer. Women and children from developing countries are the most exposed populations. A workshop was held in Arlington, Virginia, 9-11 May 2011, to better understand women's and children's potential health effects from IAP in developing countries. Workshop participants included international scientists, manufacturers, policy and regulatory officials, community leaders, and advocates who held extensive discussions to help identify future research needs.
  
  
  OBJECTIVE
  Our objective was to identify research opportunities regarding IAP and cancer, including research questions that could be incorporated into studies of interventions to reduce IAP exposure. In this commentary, we describe the state of the science in understanding IAP and its associations with cancer and suggest research opportunities for improving our understanding of the issues.
  
  
  CONCLUSIONS
  Opportunities for research on IAP and cancer include studies of the effect of IAP on cancers other than lung cancer; studies of genetic factors that modify susceptibility; studies to determine whether the effects of IAP are mediated via germline, somatic, and/or epigenetic changes; and studies of the effects of IAP exposure via dermal and/or oral routes.
  
  
  CONCLUSIONS
  IAP from indoor coal use increases the risk of lung cancer. Installing chimneys can reduce risk, and some genotypes, including GSTM1-null, can increase risk. Additional research is needed regarding the effects of IAP on other cancers and the effects of different types of solid fuels, oral and dermal routes of IAP exposure, genetic and epigenetic mechanisms, and genetic susceptibility.
authors: Modifiable Risk Factors Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. reidbr@mail.nih.gov
authors: Britt C
authors: BC
authors: Reid
authors: Armen A
authors: AA
authors: Ghazarian
authors: David M
authors: DM
authors: DeMarini
authors: Amir
authors: A
authors: Sapkota
authors: Darby
authors: D
authors: Jack
authors: Qing
authors: Q
authors: Lan
authors: Deborah M
authors: DM
authors: Winn
authors: Linda S
authors: LS
authors: Birnbaum
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000517:prevention & control; D002606:Charcoal / Q000633:toxicity; D003031:Coal / Q000633:toxicity; D003296:Cooking; D003906:Developing Countries; D005243:Feces; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000209:etiology; D006361:Heating; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology* / Q000235:genetics; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D014934:Wood / Q000633:toxicity
chemical_list: D003031:Coal; D002606:Charcoal