title: A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer.
abstract: BACKGROUND
  This multicenter study aimed to create and validate a scoring system for survival of patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The entire cohort of 356 patients was divided in a test group (N = 178) and a validation group (N = 178). In the test group, nine pre-treatment factors including age, gender, Eastern Cooperative Oncology Group performance status (ECOG-PS), number of involved vertebrae, pre-radiotherapy ambulatory status, other bone metastases, visceral metastases, interval from cancer diagnosis to radiotherapy of MSCC, and the time developing motor were retrospectively analyzed.
  
  
  RESULTS
  On multivariate analysis, survival was significantly associated with ECOG-PS, pre-radiotherapy ambulatory status, visceral metastases, and the time developing motor deficits. These factors were included in the scoring system; the score for each factor was determined by dividing the 6-month survival rate (in %) by 10. The risk score represented the sum of the scores for each factor. According to the risk scores, which ranged from 6 to 19 points, three prognostic groups were designed. The 6-month survival rates were 6% for 6-10 points, 29% for 11-15 points, and 78% for 16-19 points (p < 0.001). In the validation group, the 6-month survival rates were 4%, 24%, and 76%, respectively (p < 0.001).
  
  
  CONCLUSIONS
  Since the survival rates of the validation group were similar to those of the test group, this score can be considered reproducible. The scoring system can help when selecting the individual treatment for patients with MSCC from NSCLC. A prospective confirmatory study is warranted.
authors: Department of Radiation Oncology, University of Lubeck, Lubeck, Germany. rades.dirk@gmx.net
authors: Dirk
authors: D
authors: Rades
authors: Sarah
authors: S
authors: Douglas
authors: Theo
authors: T
authors: Veninga
authors: Steven E
authors: SE
authors: Schild
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D013117:Spinal Cord Compression / Q000209:etiology* / Q000401:mortality*; D013125:Spinal Neoplasms / Q000150:complications* / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D015996:Survival Rate