title: PCOS patients can benefit from in vitro maturation (IVM) of oocytes.
abstract: OBJECTIVE
  Our aim was to compare treatment outcome following in vitro maturation (IVM) compared with IVF in patients with polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  Retrospective evaluation of treatment in women with PCOS who underwent IVM (108) and IVF (108).
  
  
  RESULTS
  We found a significant difference in outcome between IVM and IVF, with an increase in the number of mature oocytes derived (10.5 ± 6.5 vs. 15.3 ± 8.8, p<0.0001) and the cleavage rate (92.4 ± 13.0 vs. 95.2 ± 11.7, p=0.03) in IVM cycles. Due to the lower implantation rate (16.1% vs. 21.6%, p=0.07) we tend to transfer more embryos in the IVM group (3.4 ± 0.8 vs. 2.8 ± 1.0, p<0.0001), but the multiple pregnancy rate in that group was not higher. Importantly, the delivery rate was similar in both groups (26.8% vs. 25%). We also report a yearly change in the success rate of IVM during this period.
  
  
  CONCLUSIONS
  IVM treatment for PCOS patients may be a valid alternative treatment to IVF with the advantage of eliminating the risk of OHSS and reducing the cost of medication, whilst maintaining high clinical pregnancy rate.
authors: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. 100paz@walla.co.il
authors: Einat
authors: E
authors: Shalom-Paz
authors: Hananel
authors: H
authors: Holzer
authors: Weon- Young
authors: W
authors: Son
authors: Ishai
authors: I
authors: Levin
authors: Seang Lin
authors: SL
authors: Tan
authors: Benny
authors: B
authors: Almog
mesh_terms: D000328:Adult; D004477:Ectogenesis; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006785:Hospitals, University; D006786:Hospitals, Urban; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D050498:Live Birth; D008499:Medical Records; D054315:Oocyte Retrieval; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011792:Quebec / Q000453:epidemiology; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic