title: Antidepressants prevent hierarchy destabilization induced by lipopolysaccharide administration in mice: a neurobiological approach to depression.
abstract: In spite of the high prevalence and negative impact of depression, little is known about its pathophysiology. Basic research on depression needs new animal models in order to increase knowledge of the disease and search for new therapies. The work presented here aims to provide a neurobiologically validated model for investigating the relationships among sickness behavior, antidepressants treatment, and social dominance behavior. For this purpose, dominant individuals from dyads of male Swiss mice were treated with the bacterial endotoxin lipopolysaccharide (LPS) to induce social hierarchy destabilization. Two groups were treated with the antidepressants imipramine and fluoxetine prior to LPS administration. In these groups, antidepressant treatment prevented the occurrence of social destabilization. These results indicate that this model could be useful in providing new insights into the understanding of the brain systems involved in depression.
authors: Neuroimmunomodulation Research Group, Department of Pathology, School of Veterinary Medicine, University of São Paulo, Brazil. dcohn@usp.br
authors: Daniel Wagner Hamada
authors: DW
authors: Cohn
authors: Denise
authors: D
authors: Kinoshita
authors: João
authors: J
authors: Palermo-Neto
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D016207:Cytokines / Q000502:physiology; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D005473:Fluoxetine / Q000494:pharmacology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D012701:Serotonin / Q000502:physiology; D012919:Social Behavior
chemical_list: D000928:Antidepressive Agents; D016207:Cytokines; D008070:Lipopolysaccharides; D005473:Fluoxetine; D012701:Serotonin; D007099:Imipramine