title: The relationship between Cyclin G1 and survival in patients treated surgically for HCC.
abstract: OBJECTIVE
  Cyclin G1 is a cell-cycle-regulatory protein that is frequently seen in elevated amounts in malignant tissue, including astrocytomas; melanoma; carcinoma of the esophagus, lung, and breast; as well as cancer of the cervix, uterus, and ovary. By contrast, it has demonstrated inhibitory activity in human hepatocellular carcinoma (HCC).
  
  
  METHODS
  We investigated the role of cyclin G1 in HCC tissue obtained from 76 donors using immunohistochemistry and Western blot analysis to explore its relationship with HCC pathology and univariate and multivariate analyses to explore its relationship with surgical prognosis and patient survival.
  
  
  RESULTS
  We found that cyclin G1 levels were increased in normal tissue compared with HCC tissue and vary over the course of the cell cycle, with equal distribution between the nucleus and cytoplasm observed during normal serum support and accelerated release from the nucleus into the cytoplasm observed during serum starvation.
  
  
  CONCLUSIONS
  Our findings suggest a role for cyclin G1 in anti-HCC gene therapy.
authors: Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
authors: Xiaopeng
authors: X
authors: Cui
authors: Litao
authors: L
authors: Yu
authors: Yingying
authors: Y
authors: Wang
authors: Song
authors: S
authors: He
authors: Yixin
authors: Y
authors: Zhang
authors: Chunhua
authors: C
authors: Wan
authors: Jing
authors: J
authors: Shi
authors: Wenyang
authors: W
authors: Jiang
authors: Jing
authors: J
authors: Zhang
authors: Guanglin
authors: G
authors: Mei
authors: Runzhou
authors: R
authors: Ni
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D056766:Cyclin G1 / Q000032:analysis / Q000502:physiology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged
chemical_list: C534702:CCNG1 protein, human; D056766:Cyclin G1