title: A NIR BODIPY dye bearing 3,4,4a-trihydroxanthene moieties.
abstract: A novel 3,4,4a-trihydroxanthene-fused pyrrole 2 was synthesized by the reaction of 2,3,4,4a-tetrahydro-1H-xanthen-1-one with 3-phenyl-2H-azirine in the presence of LDA. Utilizing this pyrrole 2, a NIR BODIPY 1 (λ(abs) = 732 nm, λ(em) = 747 nm) has been prepared. The new BODIPY 1 was stable, non-cytotoxic, and suited to labeling living cells for imaging assay in the NIR region.
authors: The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng, Henan 475004, China. xdjiang@henu.edu.cn
authors: Xin-Dong
authors: XD
authors: Jiang
authors: Ruina
authors: R
authors: Gao
authors: Yi
authors: Y
authors: Yue
authors: Guo-Tao
authors: GT
authors: Sun
authors: Weili
authors: W
authors: Zhao
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D056945:Hep G2 Cells; D006801:Humans; D007259:Infrared Rays; D011758:Pyrroles / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D011758:Pyrroles; D014966:Xanthenes