title: Astragalus polysaccharide and sulfated epimedium polysaccharide synergistically resist the immunosuppression.
abstract: The immunoenhancement of compound polysaccharides, APS-sEPS composed with astragalus polysaccharide (APS) and sulfated epimedium polysaccharide (sEPS), was observed in immunosuppressed model chicken induced by cyclophosphamide (Cy). 11-day-old chickens were injected with Cy once a day for three successive days except vaccine control group. At day-14-old, all chickens were vaccinated with ND vaccine, and in experimental groups simultaneously administrated with APS-sEPS at three dosages, APS and sEPS once a day for three successive days. On days 7, 14, 21 and 28 after the administration, the peripheral T-lymphocyte proliferation, serum antibody titers, IFN-γ, IL-2, IgG and IgM were determined. The results displayed that APS-sEPS could overcome Cy-induced immunosuppression, significantly promote T-lymphocyte proliferation and raised serum antibody titers, IFN-γ, IL-2, IgG and IgM levels, its high and medium doses were superior to single APS or sEPS. This demonstrated that APS and sEPS could synergistically resist the immunosuppression and APS-sEPS was an effective immunopotentiator.
authors: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China.
authors: Liwei
authors: L
authors: Guo
authors: Jiaguo
authors: J
authors: Liu
authors: Yuanliang
authors: Y
authors: Hu
authors: Deyun
authors: D
authors: Wang
authors: Zhizhong
authors: Z
authors: Li
authors: Jing
authors: J
authors: Zhang
authors: Tao
authors: T
authors: Qin
authors: Xu
authors: X
authors: Liu
authors: Cui
authors: C
authors: Liu
authors: Xiaojuan
authors: X
authors: Zhao
authors: Yun Peng
authors: YP
authors: Fan
authors: Guocai
authors: G
authors: Han
authors: The Luong
authors: TL
authors: Nguyen
mesh_terms: D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry; D002645:Chickens / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D034181:Epimedium / Q000737:chemistry; D007108:Immune Tolerance / Q000187:drug effects*; D016867:Immunocompromised Host / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D011134:Polysaccharides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D007166:Immunosuppressive Agents; C424862:Newcastle disease virus vaccine MTH-68-H; D011134:Polysaccharides; D013431:Sulfates; D014765:Viral Vaccines; D003520:Cyclophosphamide