title: Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.
abstract: Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between these classes of molecules are, not surprisingly, highly complex and are dependent on the tissue, cellular, and molecular settings.
authors: Department of Renal Medicine, King's College London, London, UK.
authors: Qihe
authors: Q
authors: Xu
authors: Jeffrey B
authors: JB
authors: Kopp
mesh_terms: D047108:Embryonic Development / Q000502:physiology; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000276:immunology / Q000378:metabolism; D047488:Retinoid X Receptors / Q000276:immunology / Q000378:metabolism; D012176:Retinoids / Q000276:immunology / Q000378:metabolism* / Q000627:therapeutic use; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000378:metabolism*; D014212:Tretinoin / Q000276:immunology / Q000378:metabolism; D014801:Vitamin A / Q000276:immunology / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D016212:Transforming Growth Factor beta; D014801:Vitamin A; D014212:Tretinoin