title: Therapeutic potential of mesenchymal stem cells for oral and systemic diseases.
abstract: Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.
authors: Division of Restorative Dentistry, University of California Los Angeles School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors: Reuben H
authors: RH
authors: Kim
authors: Shebli
authors: S
authors: Mehrazarin
authors: Mo K
authors: MK
authors: Kang
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy; D002454:Cell Differentiation / Q000502:physiology; D003785:Dental Pulp Capping / Q000379:methods; D003817:Dentition; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D009059:Mouth Diseases / Q000628:therapy*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D012871:Skin Diseases / Q000628:therapy; D023822:Tissue Engineering / Q000379:methods*