title: A comparison of bone mineral density in normal weight and obese adolescents with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate whether there are any differences in bone mineral density (BMD) between normal weight and obese adolescents suffering from polycystic ovary syndrome (PCOS) with oligo/amenorrhea.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Adolescent gynecology clinic in a general service hospital.
  
  
  METHODS
  Subjects consisted of adolescents between 16 to 18 years of age presenting with oligo/ amenorrhea with ultrasound morphology of polycystic ovaries ± evidence of hyperandrogenism over 24 months. Controls consisted of consecutive eumenorrheic patients within the same age group.
  
  
  METHODS
  All underwent full hormonal profile assessment, and dual energy X-ray absorptiometry and peripheral quantitative computed tomography scans.
  
  
  METHODS
  Areal and volumetric BMD parameters.
  
  
  RESULTS
  Of 37 adolescents with PCOS, 12 (32%) were obese with BMI ≥25, of which 9/12 (75%) were hyperandrogenic. The control group consisted of 40 normal weight eumenorrheic girls. The PCOS group overall had lower lumbar spine BMD values as compared to the controls (0.91 vs 0.97 g/ cm(2), P = 0.033). The normal weight PCOS group had lower BMD at the spine (0.90 vs 0.97 g/ cm(2), P = 0.027), trochanter (0.66 vs 0.71 g/ cm(2), P = 0.039) as well as volumetric distal tibial core sites (268 vs 296 mg/ cm(3)) as compared to eumenorrheic controls, but there were no significant BMD differences between the obese PCOS group and the eumenorrheic controls.
  
  
  CONCLUSIONS
  Normal weight PCOS adolescents with oligo/amenorrhea have marginally lower BMD values than controls, but obese PCOS adolescents have BMD values compatible with eumenorrheic adolescents.
authors: Department of Obstetrics and Gynecology, United Christian Hospital, Kowloon, Hong Kong SAR. towkw@ha.org.hk
authors: William W K
authors: WW
authors: To
authors: Margaret W N
authors: MW
authors: Wong
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000568:Amenorrhea / Q000150:complications / Q000503:physiopathology; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications*; D009839:Oligomenorrhea / Q000150:complications / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed