title: Oral ethanol self-administration in inbred Roman high- and low-avoidance rats: gradual versus abrupt ethanol presentation.
abstract: Outbred Roman high-avoidance rats are known to consume more ethanol than inbred Roman low-avoidance rats. To determine whether ethanol consumption in inbred strains could be modulated by experiential factors, preference for a target 10% ethanol concentration was tested after either the gradual introduction of ethanol in increasing concentrations or the abrupt introduction of the target concentration. Whereas high-avoidance rats consumed more ethanol at lower concentrations, consumption and preference for ethanol over water were not differential across strains and administration procedure (gradual vs. abrupt). At the 4% concentration, ethanol was preferred over water by Roman high-avoidance rats, but water was preferred over ethanol by Roman low-avoidance rats. Ethanol consumption and preference for a 10% concentration appear to be immune to modification by either the gradual or abrupt ethanol presentation.
authors: Universidad de Jaén, Spain.
authors: Lidia
authors: L
authors: Manzo
authors: M José
authors: MJ
authors: Gómez
authors: José E
authors: JE
authors: Callejas-Aguilera
authors: Alberto
authors: A
authors: Fernández-Teruel
authors: Mauricio R
authors: MR
authors: Papini
authors: Carmen
authors: C
authors: Torres
mesh_terms: D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D005518:Food Preferences / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012646:Self Administration
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol