title: Magnetic resonance imaging findings in patients with systemic scleroderma and musculoskeletal symptoms.
abstract: OBJECTIVE
  To explore the role of whole-body magnetic resonance imaging (MRI) in detecting musculoskeletal involvement in patients with systemic scleroderma and musculoskeletal symptoms.
  
  
  METHODS
  Eighteen consecutive patients (8 men, 10 women) with systemic scleroderma (median age 46 years) presenting with musculoskeletal complaints underwent whole-body MRI at 1.5 T. Images were evaluated for abnormal signal intensity and/or thickening of subcutaneous fatty tissue septa, muscular fasciae, intramuscular perifascial septa, muscle signal intensity and articular or tendon sheath synovial abnormalities on STIR and post-gadolinium scans. Additionally, C-reactive protein, creatinine kinase and the modified Rodnan skin score were determined.
  
  
  RESULTS
  MRI indicated evidence of fasciitis, articular synovial inflammation, and subcutaneous thickening in 16 (89 %) patients. MRI findings were compatible with myopathy or myositis in 14 (78 %) patients, tenosynovitis in 11 (61 %) patients and enthesitis in 10 (56 %) patients. Typically, these manifestations were distributed symmetrically and mostly generalised. We only found few correlations with modified Rodnan skin score, C-reactive protein and creatinine kinase.
  
  
  CONCLUSIONS
  In patients with systemic scleroderma experiencing musculoskeletal symptoms, whole-body MRI is able to detect involvement of muscles, fasciae, joints and entheses more confidently compared with clinical and laboratory parameters.
authors: Department of Dermatology, Eberhard Karls University Tuebingen, Liebermeister-Str. 25, 72076, Tuebingen, Germany.
authors: Stefan
authors: S
authors: Schanz
authors: Jörg
authors: J
authors: Henes
authors: Anja
authors: A
authors: Ulmer
authors: Ina
authors: I
authors: Kötter
authors: Gerhard
authors: G
authors: Fierlbeck
authors: C D
authors: CD
authors: Claussen
authors: Marius
authors: M
authors: Horger
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009141:Musculoskeletal System / Q000473:pathology*; D009942:Organometallic Compounds; D012595:Scleroderma, Systemic / Q000473:pathology*; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D019786:Gadolinium DTPA