title: Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities.
abstract: Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H(37)Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1μM, respectively.
authors: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
authors: Ho-Chen
authors: HC
authors: Wu
authors: Ming-Jen
authors: MJ
authors: Cheng
authors: Chien-Fang
authors: CF
authors: Peng
authors: Shyh-Chyun
authors: SC
authors: Yang
authors: Hsun-Shuo
authors: HS
authors: Chang
authors: Chu-Hung
authors: CH
authors: Lin
authors: Chyi-Jia
authors: CJ
authors: Wang
authors: Ih-Sheng
authors: IS
authors: Chen
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D029525:Juglandaceae / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts