title: Obese children suffer more often from migraine.
abstract: OBJECTIVE
  To determine a possible relationship between migraine and body mass index.
  
  
  METHODS
  Migraine shows a wide spectrum of comorbidities, including cardiocerebral, vascular, psychiatric, metabolic, neurological as well as other pathologies. Recent researches suggest that obesity was significantly correlated with migraine frequency and disability in children, as well as in adult population studies. We reviewed data from the literature to clarify this possible relationship.
  
  
  RESULTS
  Translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. A relationship between migraine and body mass index exists, and therefore, interventions to modify body mass index may provide a useful treatment model for investigating whether modest weight loss reduces headache frequency and severity in obese migraineurs.
  
  
  CONCLUSIONS
  The effect of obesity and weight change on headache outcomes may have important implications for clinical care.
authors: Department of Pediatrics, University of Chieti, Italy.
authors: Alberto
authors: A
authors: Verrotti
authors: Alessia
authors: A
authors: Di Fonzo
authors: Sergio
authors: S
authors: Agostinelli
authors: Giangennaro
authors: G
authors: Coppola
authors: Milena
authors: M
authors: Margiotta
authors: Pasquale
authors: P
authors: Parisi
mesh_terms: D001007:Anxiety / Q000150:complications; D015992:Body Mass Index; D003863:Depression / Q000150:complications; D006801:Humans; D007378:Interleukins / Q000502:physiology; D008881:Migraine Disorders / Q000150:complications* / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D057170:Translational Research, Biomedical
chemical_list: D007378:Interleukins; D018377:Neurotransmitter Agents