title: Iron-catalyzed formation of 2-aminopyridines from diynes and cyanamides.
abstract: Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.
authors: Department of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, Utah 84112-0850, USA.
authors: Timothy K
authors: TK
authors: Lane
authors: Brendan R
authors: BR
authors: D'Souza
authors: Janis
authors: J
authors: Louie
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003484:Cyanamide / Q000737:chemistry*; D003500:Cyclization; D053280:Diynes / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000631:Aminopyridines; D053280:Diynes; D003484:Cyanamide; D007501:Iron; C032439:alpha-aminopyridine