title: Mechanistic insights into the regulation of metabolic enzymes by acetylation.
abstract: The activity of metabolic enzymes is controlled by three principle levels: the amount of enzyme, the catalytic activity, and the accessibility of substrates. Reversible lysine acetylation is emerging as a major regulatory mechanism in metabolism that is involved in all three levels of controlling metabolic enzymes and is altered frequently in human diseases. Acetylation rivals other common posttranslational modifications in cell regulation not only in the number of substrates it modifies, but also the variety of regulatory mechanisms it facilitates.
authors: Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, Shanghai 20032, China. yxiong@email.unc.edu
authors: Yue
authors: Y
authors: Xiong
authors: Kun-Liang
authors: KL
authors: Guan
mesh_terms: D000107:Acetylation; D000494:Allosteric Regulation / Q000502:physiology; D000818:Animals; D020134:Catalytic Domain / Q000502:physiology; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008660:Metabolism / Q000502:physiology*; D051379:Mice; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational / Q000502:physiology
chemical_list: D004798:Enzymes; D046988:Proteasome Endopeptidase Complex; D008239:Lysine