title: The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro.
abstract: In this study, we prepared an acidic polysaccharide (CPPA) from the roots of Codonopsis pilosula. The effects of CPPA on tumor cell growth, invasion, and migration were examined in vitro. The CPPA not only induced a potent inhibitory effect on the invasion and migration potential of human epithelial ovarian cancer HO-8910 cells in vitro, evaluated by wound healing, transwell and cell adhesion assays, but also had an efficient anti-proliferation effect on tumor cells. Moreover, the CD44 expression on the HO-8910 cells was also attenuated by CPPA treatment. Therefore, our results indicate that CPPA may be a potential candidate compound for the prevention of tumor metastasis, presumably by inhibiting invasion, migration and adhesion of tumor cells, as well as the CD44 expression on the tumor cells.
authors: Department of Medical Oncology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China.
authors: Tao
authors: T
authors: Xin
authors: Fubin
authors: F
authors: Zhang
authors: Qiuying
authors: Q
authors: Jiang
authors: Chunhong
authors: C
authors: Chen
authors: Dayong
authors: D
authors: Huang
authors: Yanju
authors: Y
authors: Li
authors: Weixi
authors: W
authors: Shen
authors: Yinghua
authors: Y
authors: Jin
authors: Guangjie
authors: G
authors: Sui
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D055598:Chemical Phenomena; D029745:Codonopsis / Q000737:chemistry*; D003094:Collagen / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007797:Laminin / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000473:pathology*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D018960:Hyaluronan Receptors; D007797:Laminin; D011134:Polysaccharides; D011509:Proteoglycans; C059485:matrigel; D003094:Collagen