title: Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies.
abstract: We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment response on prognosis. Sixty-five patients treated between January 1998 and December 2008, and whose follow-up duration was more than 2 years were included. The Response Evaluation Criteria in Solid Tumors (version 1.1) was used for the evaluation of treatment. Median age was 59 years (range 21-83 years). Olfactory neuroblastoma (n = 20, 30%) and squamous cell carcinoma (n = 15, 23%) were the major pathological tumor types. The median follow-up duration was 51.6 months. Radiological response evaluation within 6 months after treatment demonstrated that 15% of the patients achieved complete response (CR), and 3-year progression free survival rates of all patients was 49.2%. The 3-year PFS rates according to response for the treatment were 55.6% in the patients with CR and 46.4% in those with non-CR, respectively (P = 0.643). However, the 3-year PFS rates were 80.% in the patients with CR and 10.% in those with non-CR (P = 0.051) in the patients with squamous cell carcinoma (SCC) histology. Radiological response evaluation within 6 months did not have a significant impact on prognosis when analysis included all histology, although early radiological response within 6 months after RT had a borderline significant impact on treatment outcomes for the patients with nasal and paranasal SCC.
authors: Graduate School of Medicine Department of Radiology, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. hojo-h@juntendo.ac.jp
authors: Hidehiro
authors: H
authors: Hojo
authors: Sadamoto
authors: S
authors: Zenda
authors: Tetsuo
authors: T
authors: Akimoto
authors: Ryosuke
authors: R
authors: Kohno
authors: Mitsuhiko
authors: M
authors: Kawashima
authors: Satoko
authors: S
authors: Arahira
authors: Teiji
authors: T
authors: Nishio
authors: Makoto
authors: M
authors: Tahara
authors: Ryuichi
authors: R
authors: Hayashi
authors: Keisuke
authors: K
authors: Sasai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D018572:Disease-Free Survival; D018304:Esthesioneuroblastoma, Olfactory / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000532:radiotherapy*; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy*; D011379:Prognosis; D061766:Proton Therapy; D012189:Retrospective Studies; D055815:Young Adult; D011522:Protons
chemical_list: D011522:Protons