title: Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance.
abstract: Double-positive (DP) CD4(+) CD8(+)  T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4(+)  or CD8(+)  single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The detection of an activated DP population in the periphery, a population that expresses T cell receptors unselected during thymic negative selection in murine models of Trypanosoma cruzi infection and in humans with Chagas disease, raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and its possible link with immunoendocrine alterations.
authors: Institute of Immunology, Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina. perez_anarosa@yahoo.com.ar
authors: Ana R
authors: AR
authors: Pérez
authors: Alexandre
authors: A
authors: Morrot
authors: Luiz R
authors: LR
authors: Berbert
authors: Eugenia
authors: E
authors: Terra-Granado
authors: Wilson
authors: W
authors: Savino
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D014355:Chagas Disease / Q000276:immunology* / Q000503:physiopathology; D019314:Dehydroepiandrosterone Sulfate / Q000276:immunology; D004195:Disease Models, Animal; D004702:Endocrine Glands / Q000276:immunology; D006801:Humans; D006854:Hydrocortisone / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone