title: Structural and functional changes in pulmonary macrophages and lungs of mice infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05.
abstract: C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination.
authors: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors: A V
authors: AV
authors: Kovner
authors: A G
authors: AG
authors: Anikina
authors: O V
authors: OV
authors: Potapova
authors: T V
authors: TV
authors: Sharkova
authors: L A
authors: LA
authors: Cherdanceva
authors: V A
authors: VA
authors: Shkurupy
authors: A M
authors: AM
authors: Shestopalov
mesh_terms: D000818:Animals; D002402:Cathepsin D / Q000378:metabolism; D004195:Disease Models, Animal; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification; D015850:Interleukin-6 / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016676:Macrophages, Alveolar / Q000166:cytology / Q000378:metabolism* / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009113:Muramidase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D009195:Peroxidase / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C505534:Fadd protein, mouse; D053200:Fas-Associated Death Domain Protein; D015850:Interleukin-6; D053221:TNF-Related Apoptosis-Inducing Ligand; C505654:Tnfsf10 protein, mouse; D014409:Tumor Necrosis Factor-alpha; D009195:Peroxidase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D009113:Muramidase; D002402:Cathepsin D