title: Expression of stem cell markers, CD133 and CD44, in pediatric solid tumors: a study using tissue microarray.
abstract: Based on the cancer stem cell (CSC) concept model, a small population of cells with unique self-renewal properties and malignant potential exists in tumors. Immunohistochemistry was performed to detect the expression of CSC markers, CD133 and CD44, in a series of pediatric tumors. The association between expression of these markers and tumor characteristics was then analyzed. In Wilms tumors (WT), a significant positive correlation was found between expression of CD133 and the National Wilms Tumor Stage (NWTS) (p = 0.047). In neuroblastomas (NB), expression of CD133 was positively correlated with the International Neuroblastoma Staging System (INSS) (p-value = 0.012), indicating that the rate of CD133 positivity increased with the stage of these tumors. CD133, as a putative stem cell marker, is associated with more advanced stages of Wilms and NB tumors; therefore, this molecule can be a potential clinical prognostic marker in children suffering from NB or Wilms tumor.
authors: Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mitra
authors: M
authors: Mehrazma
authors: Zahra
authors: Z
authors: Madjd
authors: Elham
authors: E
authors: Kalantari
authors: Mahshid
authors: M
authors: Panahi
authors: Alireza
authors: A
authors: Hendi
authors: Ahmad
authors: A
authors: Shariftabrizi
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007223:Infant; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010455:Peptides / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology; D046888:Tissue Array Analysis; D009396:Wilms Tumor / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C000606023:PROM1 protein, human; D010455:Peptides