title: Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutane sulfonate.
abstract: Perfluoroalkyl acids (PFAAs) are persistent environmental contaminants resistant to biological and chemical degradation due to the presence of carbon-fluorine bonds. These compounds exhibit developmental toxicity in vitro and in vivo. The mechanisms of toxicity may involve partitioning into lipid bilayers. We investigated the interaction between perfluorobutane sulfonate (PFBS), an emerging PFAA, and model phosphatidylcholine (PC) lipid assemblies (i.e., dimyristoyl-, dipalmitoyl- and distearoylphosphatidylcholine) using fluorescence anisotropy and Langmuir monolayer techniques. PFBS decreased the transition temperature and transition width of PC bilayers. The apparent membrane partition coefficients ranged from 4.9 × 10(2) to 8.2 × 10(2). The effects on each PC were comparable. The limiting molecular area of PC monolayers increased, and the surface pressure at collapse decreased in a concentration-dependent manner. The compressibility of all three PCs was decreased by PFBS. In summary, PFBS disrupted different model lipid assemblies, indicating potential for PFBS to be a human toxicant. However, the effects of PFBS are not as pronounced as those seen with longer chain PFAAs.
authors: Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA.
authors: E Davis
authors: ED
authors: Oldham
authors: Wei
authors: W
authors: Xie
authors: Amir M
authors: AM
authors: Farnoud
authors: Jennifer
authors: J
authors: Fiegel
authors: Hans-Joachim
authors: HJ
authors: Lehmler
mesh_terms: D000388:Air; D016880:Anisotropy; D005453:Fluorescence; D005466:Fluorocarbons / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D005466:Fluorocarbons; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D014867:Water; C108042:perfluorobutane