title: [The experience of the application of ascorbinic acid as antioxidant after coronary artery surgery with use of cardiopulmonary bypass].
abstract: We have studied the role of oxidant stress in development of rhythm disturbances in early postoperative period after coronary artery bypass grafting and possibilities of their prevention with preparations of ascorbinic acid. It was shown that the use of β-adrenoblockers allows to prevent arrhythmia on first day after operation only in 80% of cases. Patients with developed disturbances of cardiac rhythm were characterized by high parameters of lipid peroxidation (LPO) and substantial changes of activity of antioxidant enzyme catalase. Administration of ascorbinic acid at the stage of preparation of patients to surgery and in first 24 hours after operation allowed to effectively prevent development of oxidative stress and disturbances of cardiac rhythm. A conclusion was made that inclusion of ascorbinic acid in drug therapy of patients with ischemic heart disease could be recommended for prevention of arrhythmia in postoperative period.
authors: T Iu
authors: TIu
authors: Rebrova
authors: V M
authors: VM
authors: Shipulin
authors: S A
authors: SA
authors: Afanas'ev
authors: E V
authors: EV
authors: Vorob'eva
authors: O G
authors: OG
authors: Kiĭko
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D016903:Drug Monitoring; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000628:therapy; D018384:Oxidative Stress / Q000187:drug effects*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid