title: Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study.
abstract: The aim of this cross-sectional study was to investigate the association between sedative load and functional outcomes in community-dwelling older Australian men. A total of 1696 males aged ≥ 70 years, enrolled in the Concord Health and Ageing in Men Project, were studied. Participants underwent assessments during 2005-2007. Sedative load was computed using a published model. Outcomes included activities of daily living (ADL), instrumental activities of daily living (IADL), physical performance measures and a clinical diagnosis of cognitive impairment. Of the participants, 15.3% took medications with sedative properties. After adjusting for age, education, depressive symptoms and comorbidities, participants who took one medication with sedation as a prominent side effect (sedative load = 1) had odds ratio (OR) of 2.15 (95% confidence interval, CI: 1.20-3.85) for ADL disability, compared with participants with sedative load = 0. Participants who took at least one primary sedative or two medications with sedation as a prominent side effect (sedative load ≥ 2) had an OR of 1.55 (95% CI: 1.02-2.35) for IADL disability, compared with participants with sedative load = 0. The mean 6-m walking speed (P = 0.001) and grip strength (P = 0.003) were significantly different between sedative load groups in unadjusted models only. No association between sedative load and poorer performance on balance and chair stands tests or cognitive impairment was observed. Participants with sedative load of one were more likely to report ADL disability, whereas participants with sedative load of ≥2 were more likely to report IADL disability. Higher sedative load was not associated with poorer physical performance or cognitive impairment in older Australian men.
authors: Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Centre for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia; Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
authors: Danijela
authors: D
authors: Gnjidic
authors: David G
authors: DG
authors: Le Couteur
authors: Sarah N
authors: SN
authors: Hilmer
authors: Robert G
authors: RG
authors: Cumming
authors: Fiona M
authors: FM
authors: Blyth
authors: Vasi
authors: V
authors: Naganathan
authors: Louise
authors: L
authors: Waite
authors: David J
authors: DJ
authors: Handelsman
authors: John Simon
authors: JS
authors: Bell
authors: Bell
authors: B
authors: J S
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000375:Aging / Q000502:physiology; D001315:Australia; D003430:Cross-Sectional Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D012111:Residence Characteristics
chemical_list: D006993:Hypnotics and Sedatives