title: Using platelet-rich plasma for the treatment of symptomatic cervical ectopy.
abstract: OBJECTIVE
  To evaluate the effectiveness of autologous platelet-rich plasma (PRP) applications in the treatment of benign cervical ectopy.
  
  
  METHODS
  Symptomatic women with benign cervical ectopy (n=120) were randomized to a PRP or a laser group. In the PRP group, PRP was applied twice on the cervical erosion with a 1-week interval. In the laser group, an Nd-YAG laser was used once for tissue vaporization.
  
  
  RESULTS
  The complete cure rates were 93.7% for the PRP and 92.4% for the laser group (P>0.05). The mean time to re-epithelialization was significantly shorter in the PRP (6.41 ± 2.05 weeks) than in the laser group (8.28 ± 1.72 weeks) (P<0.01). The rate of adverse treatment effects (i.e. vaginal discharge or vaginal bleeding) was much lower in the PRP than that in the laser group (P<0.01) and the effects were milder. Eleven patients in the PRP group had mild or moderate vaginal bleeding after treatment but none had heavy bleeding. Of 25 patients with vaginal bleeding in the laser group, 2 had heavy bleeding necessitating tamponade.
  
  
  CONCLUSIONS
  Autologous PRP applications appear promising for the treatment of cervical ectopy in symptomatic women, as they generate a shorter tissue healing time and milder adverse effects than laser treatment.
authors: Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Xiaolin
authors: X
authors: Hua
authors: Yan
authors: Y
authors: Zeng
authors: Rongrong
authors: R
authors: Zhang
authors: Hong
authors: H
authors: Wang
authors: Jing
authors: J
authors: Diao
authors: Ping
authors: P
authors: Zhang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D053657:Platelet-Rich Plasma; D012720:Severity of Illness Index; D058738:Uterine Balloon Tamponade; D002578:Uterine Cervical Dysplasia / Q000628:therapy*; D014592:Uterine Hemorrhage / Q000209:etiology; D019522:Vaginal Discharge / Q000209:etiology; D014945:Wound Healing