title: Data on Wistar Hannover rats from a general toxicity study.
abstract: The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.
authors: The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753-8515, Japan.
authors: Hideyuki
authors: H
authors: Yamatoya
authors: Hiroaki
authors: H
authors: Kawaguchi
authors: Kanako
authors: K
authors: Yajima
authors: Hidetomi
authors: H
authors: Kadokura
authors: Tsuyoshi
authors: T
authors: Yoshikawa
authors: Rie
authors: R
authors: Yamashita
authors: Mitsuya
authors: M
authors: Shiraishi
authors: Atsushi
authors: A
authors: Miyamoto
authors: Noriaki
authors: N
authors: Miyoshi
mesh_terms: D000367:Age Factors; D000818:Animals; D001774:Blood Chemical Analysis; D005260:Female; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012737:Sex Factors; D059550:Toxicity Tests, Subchronic; D016482:Urinalysis