title: [Respiratory reactions on microinjections of GABA and baclofen into the Bötzinger complex and the pre-Bötzinger complex in rats].
abstract: In adult anaesthetized rats the respiratory reactions to microinjections of GABA (10(-5) M) and baclofen (10(-6) M) into Botzinger complex (BC) and pre-Botzinger complex (PBC) were investigated. It was shown, that GABA microinjections into BC shortened inspiratory time and extended expiratory time while respiratory rate was not changed essentially, under this conditions the tidal volume and ventilation were increased. GABA microinjections into PBC significantly inhibited respiratory rhythm due to inspiratory and expiratory time prolongations and reduced tidal volume. The microinjections of baclofen into BC reduced expiration time and ventilation, and increased respiratory frequency whereas microinjections into PBC increased tidal volume without respiratory rate and expiratory time changes. It is suggested that the reactions observed demonstrate the various contribution of GABAergic mechanisms, including GABA(B)-receptors within BC and PBC, in control of respiratory pattern parameters.
authors: O A
authors: OA
authors: Vediasova
authors: N G
authors: NG
authors: Man'shina
authors: V A
authors: VA
authors: Safonov
authors: I A
authors: IA
authors: Tarakanov
mesh_terms: D000818:Animals; D001418:Baclofen / Q000008:administration & dosage*; D045853:Exhalation / Q000187:drug effects / Q000502:physiology; D005260:Female; D001239:Inhalation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D051381:Rats; D056152:Respiratory Rate / Q000187:drug effects / Q000502:physiology; D013990:Tidal Volume / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
chemical_list: D009125:Muscle Relaxants, Central; D005680:gamma-Aminobutyric Acid; D001418:Baclofen