title: The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate.
abstract: Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.
authors: Division of Hematopoietic Stem cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
authors: Ling
authors: L
authors: Li
authors: Ravi
authors: R
authors: Bhatia
mesh_terms: D000107:Acetylation; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D011401:Promoter Regions, Genetic; D012269:Ribosomal Proteins / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*; D050808:ets-Domain Protein Elk-4 / Q000378:metabolism
chemical_list: C494193:ELK4 protein, human; D006657:Histones; D012269:Ribosomal Proteins; C510661:SIRT7 protein, human; D050808:ets-Domain Protein Elk-4; D037761:Sirtuins