title: A phase II study of mitomycin-C and S-1 as third-line chemotherapy in patients with advanced colorectal cancer.
abstract: This study was conducted to evaluate the efficacy and safety of the combination of mitomycin-C (MMC) and S-1 as third-line chemotherapy for patients with advanced colorectal cancer (CRC) showing resistance to irinotecan- and oxaliplatin-containing regimens. Patients were recruited into the study from January 2009 and 10 patients were enrolled for 10 months. However, since no patients had shown a response by 10 months, the study was terminated early according to the protocol. MMC 7 mg/m(2) was administered intravenously on day 1 every 6 weeks in the first 4 cycles. S-1 was administered twice daily at 35 mg/m(2), within 1 h of meals on days 1-14. Following a rest for 7 days, S-1 was administered again on days 22-35, followed by a 7-day rest. A total of 14 cycles were delivered for 10 patients. All 10 patients were assessable for response. A total of 3 patients (30%) had stable disease and the remaining 7 showed disease progression. With a median follow-up of 7 months, the median overall survival was 10.5 months. Grade 3-4 myelotoxicities included neutropenia in two patients, anemia in two and thrombocytopenia in one. Grade 1-2 nausea and vomiting developed in 5 patients. One patient experienced grade 3 diarrhea. Grade 1-2 hand-foot syndrome occurred in 4 patients. In conclusion, the combination of MMC and S-1 as third-line chemotherapy in patients with advanced CRC appears to be well tolerated but has poor activity.
authors: Department of Internal Medicine, Hallym Medical Center, Hallym University College of Medicine, Seoul 150-950, Republic of Korea.
authors: Jung Han
authors: JH
authors: Kim
authors: Hyeong Su
authors: HS
authors: Kim
authors: Dae Ro
authors: DR
authors: Choi
authors: Geundoo
authors: G
authors: Jang
authors: Jung Hye
authors: JH
authors: Kwon
authors: Ho Young
authors: HY
authors: Kim
authors: Joo Young
authors: JY
authors: Jung
authors: Hyo Jung
authors: HJ
authors: Kim
authors: Hun Ho
authors: HH
authors: Song
authors: Yun Ho
authors: YH
authors: Shin
authors: So Young
authors: SY
authors: Jung
authors: Byung Chun
authors: BC
authors: Kim
authors: Dae Young
authors: DY
authors: Zang