title: Oxidative stress and epilepsy: literature review.
abstract: BACKGROUND
  The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy.
  
  
  OBJECTIVE
  A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed.
  
  
  CONCLUSIONS
  Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.
authors: School of Medicine, University of Fortaleza/RENORBIO, Rua Desembargador Floriano Benevides Magalhães, 221 3° Andar, 60811-690 Fortaleza, CE, Brazil.
authors: Carlos Clayton Torres
authors: CC
authors: Aguiar
authors: Anália Barbosa
authors: AB
authors: Almeida
authors: Paulo Victor Pontes
authors: PV
authors: Araújo
authors: Rita Neuma Dantas Cavalcante
authors: RN
authors: de Abreu
authors: Edna Maria Camelo
authors: EM
authors: Chaves
authors: Otoni Cardoso
authors: OC
authors: do Vale
authors: Danielle Silveira
authors: DS
authors: Macêdo
authors: David John
authors: DJ
authors: Woods
authors: Marta Maria de França
authors: MM
authors: Fonteles
authors: Silvania Maria Mendes
authors: SM
authors: Vasconcelos
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004827:Epilepsy / Q000473:pathology*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015538:Nitrosation; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D005609:Free Radicals