title: Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells.
abstract: The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg(2), Rg(6) and F(4) by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage.
authors: Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea.
authors: Ji Hwan
authors: JH
authors: Lee
authors: Woojung
authors: W
authors: Lee
authors: Seungyong
authors: S
authors: Lee
authors: Yujung
authors: Y
authors: Jung
authors: Soon-Hye
authors: SH
authors: Park
authors: Pilju
authors: P
authors: Choi
authors: Su-Nam
authors: SN
authors: Kim
authors: Jungyeob
authors: J
authors: Ham
authors: Ki Sung
authors: KS
authors: Kang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D019610:Cytoprotection / Q000187:drug effects*; D003603:Cytotoxins / Q000633:toxicity; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology*; D006358:Hot Temperature; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D018374:LLC-PK1 Cells; D015416:Maillard Reaction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D005894:Panax / Q000737:chemistry; D012694:Serine / Q000737:chemistry / Q000494:pharmacology*; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D003603:Cytotoxins; D036145:Ginsenosides; D012694:Serine; C049864:ginsenoside Re; D002945:Cisplatin