title: Serum C-reactive protein as a possible marker to predict delayed hemorrhage after colonoscopic polypectomy.
abstract: BACKGROUND
  Post-polypectomy hemorrhage is one of the complications of colonscopic polypectomy. And there is no definitive and convenient laboratory test that could be used to predict risk of delayed post-polypectomy hemorrhage. This research aimed to study risk prediction of delayed post-polypectomy hemorrhage using serum C-reactive protein (CRP) level as a marker.
  
  
  METHODS
  In a retrospective, case-controlled study, 302 cases of post-polypectomy patients were divided into hemorrhage group and non-hemorrhage group. The CRP levels 24-hours after colonscopic treatment were compared between the two groups to assess whether elevated serum CRP levels in addition to other risk factors such as age, gender, smoking, alcohol consumption, hypertension (AHT) and size of polyps may predict risk of delayed post-polypectomy hemorrhage.
  
  
  RESULTS
  The hemorrhage group had significantly higher levels of serum CRP (32.50±17.34 mg/L vs. 6. 32±6.02 mg/dL) and were also having a higher incidence of hypertension compared to the non- hemorrhage group (both P<0.05). Patients with elevated serum CRP levels (≥10 mg/L) after colonscopic treatment are at a higher risk of developing post-polypectomy hemorrhage (OR 1.329, 95%CI 1.125-1.571) as compared with patients whose CRP levels were not increased.
  
  
  CONCLUSIONS
  A higher level of serum CRP may serve as an indicator of delayed post-polypectomy hemorrhage and there appears to be a direct relationship between the serum CRP levels and the risk of post-polypectomy hemorrhage: the higher CRP levels the higher the risk of post-polypectomy hemorrhage.
authors: Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors: Liangqin
authors: L
authors: Wu
authors: Tiemei
authors: T
authors: Han
authors: Xiaoyuan
authors: X
authors: Fan
authors: Wensheng
authors: W
authors: Pan
authors: Chunfu
authors: C
authors: Wang
authors: Hua
authors: H
authors: Zhong
authors: Xinbo
authors: X
authors: Ai
authors: Wanjun
authors: W
authors: Zhang
authors: Xiang
authors: X
authors: Xu
authors: Zaiyuan
authors: Z
authors: Ye
authors: Takesh
authors: T
authors: Terai
authors: Nobuhiro
authors: N
authors: Sato
authors: Sumio
authors: S
authors: Watanabe
authors: Undurti N
authors: UN
authors: Das
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D003113:Colonoscopy / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007417:Intestinal Polyps / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein