title: [Evaluation of neurophysiological parameters and good metabolic control in patients with type 1 diabetes mellitus].
abstract: BACKGROUND
  Numerous authors have indicated the beneficial effect of glycoregulation on micro- and macro-angiopathic complications.
  
  
  OBJECTIVE
  The aim of the study was to examine whether intensive treatment with maintaining blood glucose concentrations close to normal range could improve electrophysiological parameters.
  
  
  METHODS
  The study involved 81 patients with type 1 diabetes mellitus type 1 randomly assigned to intensive insulin therapy. The patients were followed for a period of 3 months by metabolic and electrophysiological control. The metabolic control included daily measurement of concentration of blood glucose and HbA1c and lipid status, while the neurophysiological control included nerve conduction velocity (NCV) of median, peroneal, tibial and sural nerve and latency of F wave.
  
  
  RESULTS
  In the beginning of our study blood glucose was 9.10 +/- 3.69 mmol/l and HbA1c 8.12 +/- 1.20%. After 3 months of administered intensive insulin therapy, blood glucose was 7.88 +/- 2.79 mmol/l and HbA1c 6.63 +/- 1.33. After 3 months NCV improved in the tibial, median and sural nerve (p < 0.05) and latency of F wave.
  
  
  CONCLUSIONS
  We found a significant association between the metabolic control and NCV findings which suggests that good metabolic control influences the improvement of neurophysiological parameters in patients with type 1 diabetes mellitus.
authors: Dragana
authors: D
authors: Matanović
authors: Srdjan
authors: S
authors: Popović
authors: Biljana
authors: B
authors: Parapid
authors: Emilija
authors: E
authors: Dubljanin
authors: Dejana
authors: D
authors: Stanisavljević
authors: Tatjana
authors: T
authors: Ille
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D009431:Neural Conduction
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin