title: Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns.
abstract: OBJECTIVE
  The 1936G AKAP10 allele is associated with increased adult basal heart rate (HR) and decreased variability, markers of low cholinergic/vagus sensitivity associated with hypertension. Blood pressure (BP) values in newborns are important measurable markers of cardiovascular risk later in life. The question was whether decreased vagal function-related 1936A > G AKAP10 is associated with newborn BP.
  
  
  METHODS
  114 healthy Polish newborns born after 37th gestational week to healthy women with uncomplicated pregnancies. At birth, newborn cord blood obtained for isolation of genomic DNA. BP and HR measured on days 1 and 3 after delivery.
  
  
  RESULTS
  Diastolic BP on day 3 and absolute and relative differences between diastolic BP values, as well as between mean BP values on day 3 and on day 1 after birth, in carriers of 1936G AKAP10 allele, were significantly higher as compared with wild-type homozygotes.
  
  
  CONCLUSIONS
  Results demonstrate possible association between 1936G AKAP10 variant and BP in Polish newborns.
authors: Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland.
authors: Beata
authors: B
authors: Łoniewska
authors: Mariusz
authors: M
authors: Kaczmarczyk
authors: Jeremy S
authors: JS
authors: Clark
authors: Agnieszka
authors: A
authors: Bińczak-Kuleta
authors: Grażyna
authors: G
authors: Adler
authors: Agnieszka
authors: A
authors: Kordek
authors: Anita
authors: A
authors: Horodnicka-Józwa
authors: Grażyna
authors: G
authors: Dawid
authors: Jacek
authors: J
authors: Rudnicki
authors: Andrzej
authors: A
authors: Ciechanowicz
mesh_terms: D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001794:Blood Pressure; D001795:Blood Pressure Determination; D003971:Diastole; D005260:Female; D005838:Genotype; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014630:Vagus Nerve / Q000503:physiopathology*; D044465:White People
chemical_list: D054758:A Kinase Anchor Proteins; C484639:AKAP10 protein, human