title: Modeling uncertainty in single-copy assays for HIV.
abstract: We present a simple computational model of measurement accuracy for single-copy sensitivity assays (SCA) of HIV RNA that was developed from first principles. The model shows that the SCA is significantly right-skewed. Measured virus concentrations of 1 and 10 virions/ml had overlapping 95% confidence intervals and were statistically indistinguishable.
authors: Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA.
authors: Rutao
authors: R
authors: Luo
authors: Michael J
authors: MJ
authors: Piovoso
authors: Ryan
authors: R
authors: Zurakowski
mesh_terms: D003198:Computer Simulation; D005838:Genotype; D006678:HIV / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D015658:HIV Infections / Q000821:virology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*