title: Propofol infusion syndrome heralded by ECG changes.
abstract: BACKGROUND
  Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol. PRIS seems to be associated with young age, traumatic brain injury (TBI), higher cumulative doses of propofol, and the concomitant use of catecholamines. Known manifestations of PRIS are metabolic acidosis, rhabdomyolysis, and cardiac failure. While fatal PRIS can occur suddenly and rapidly, there is no sensitive test or early warning sign, and the only preventive measure is to limit propofol dosage and its duration.
  
  
  METHODS
  DESCRIPTION OF A SINGLE CASE:                          A case report was used for investigation purposes of this study.
  
  
  RESULTS
  We report the case study of a young patient with severe TBI, receiving propofol sedation because of high intracranial pressure. Seven days after the trauma, the patient developed metabolic acidosis and refractory circulatory shock, probably caused by PRIS. Reversal of T-waves was seen on the electrocardiogram (ECG) 29 h before circulation failure occurred. In the absence of other signs of cardiac dysfunction or ischemia, these reversed T-waves probably represent an early warning sign of developing PRIS.
  
  
  CONCLUSIONS
  From the findings of this study, we conclude that meticulous observation and analysis of the ECG during propofol sedation might result in earlier recognition of developing PRIS.
authors: Department of Intensive Care, University of Groningen, University Medical Centrum Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. ejmijzen@gmail.com
authors: Elsbeth J
authors: EJ
authors: Mijzen
authors: Bram
authors: B
authors: Jacobs
authors: Adnan
authors: A
authors: Aslan
authors: Michael G G
authors: MG
authors: Rodgers
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D001930:Brain Injuries / Q000150:complications*; D004562:Electrocardiography; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D019586:Intracranial Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D012769:Shock / Q000139:chemically induced*; D013577:Syndrome; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol