title: Reduced prefrontal hemodynamic response in pediatric obsessive-compulsive disorder as measured by near-infrared spectroscopy.
abstract: Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric disorders. Functional neuroimaging studies of patients with obsessive-compulsive disorder (OCD) have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
authors: Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522, Nara, Japan. toyosaku@naramed-u.ac.jp
authors: Toyosaku
authors: T
authors: Ota
authors: Junzo
authors: J
authors: Iida
authors: Masayuki
authors: M
authors: Sawada
authors: Yuko
authors: Y
authors: Suehiro
authors: Kazuhiko
authors: K
authors: Yamamuro
authors: Hiroki
authors: H
authors: Matsuura
authors: Shohei
authors: S
authors: Tanaka
authors: Naoko
authors: N
authors: Kishimoto
authors: Hideki
authors: H
authors: Negoro
authors: Toshifumi
authors: T
authors: Kishimoto
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002648:Child; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism / Q000503:physiopathology*; D010108:Oxyhemoglobins / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared
chemical_list: D010108:Oxyhemoglobins