title: Update on kidney transplantation in HIV-infected recipients.
abstract: HIV infection has historically been a contraindication to kidney transplantation. Prior to the era of potent antiretroviral therapy, the survival of HIV-infected patients was too poor to justify transplantation. In the last 15 years there has been substantial improvement in antiretroviral medications, such that HIV-positive patients are living longer and developing chronic diseases such as end-stage renal disease. The improvement in survival of HIV-positive patients has resulted in transplant centers increasingly considering infected patients appropriate for kidney transplantation. Recently, the results of the first prospective multicenter trial of kidney transplantation into HIV-positive candidates were released, showing the success and challenges of transplantation into this population. In light of the multicenter findings as well as national registry data, kidney transplantation should be considered the standard-of-care renal replacement therapy for HIV-positive end-stage renal disease patients and they should be referred and evaluated for kidney transplantation accordingly.
authors: University of Michigan Medical Center, Ann Arbor, MI 48109, USA. spnorman@umich.edu
authors: Silas P
authors: SP
authors: Norman
authors: Mallika
authors: M
authors: Kommareddi
authors: Daniel R
authors: DR
authors: Kaul
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000601:surgery*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000601:surgery*; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D008297:Male; D018579:Patient Selection; D012017:Referral and Consultation; D014481:United States / Q000453:epidemiology
chemical_list: D007166:Immunosuppressive Agents