title: Bioactive compounds from a gorgonian coral Echinomuricea sp. (Plexauridae).
abstract: A new labdane-type diterpenoid, echinolabdane A (1), and a new sterol, 6-epi-yonarasterol B (2), were isolated from a gorgonian coral identified as Echinomuricea sp. The structures of metabolites 1 and 2 were elucidated by spectroscopic methods. Echinolabdane A (1) possesses a novel tetracyclic skeleton with an oxepane ring jointed to an α,β-unsaturated-γ-lactone ring by a hemiketal moiety, and this compound is the first labdane-type diterpenoid to be obtained from marine organisms belonging to the phylum Cnidaria. 6-epi-Yonarasterol B (2) is the first steroid derivative to be isolated from gorgonian coral belonging to the genus Echinomuricea, and this compound displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Hsu-Ming
authors: HM
authors: Chung
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Pei-Han
authors: PH
authors: Hong
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Jui-Hsin
authors: JH
authors: Su
authors: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors: Tsong-Long
authors: 0000-0002-5780-3977
authors: TL
authors: Hwang
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Mei-Chin
authors: MC
authors: Lu
authors: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan.
authors: Lee-Shing
authors: LS
authors: Fang
authors: School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.|Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan.
authors: Yang-Chang
authors: YC
authors: Wu
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Jan-Jung
authors: JJ
authors: Li
authors: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
authors: Jih-Jung
authors: JJ
authors: Chen
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Wei-Hsien
authors: WH
authors: Wang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
authors: Ping-Jyun
authors: 0000-0002-6644-9236
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D059001:Aquatic Organisms / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013057:Spectrum Analysis / Q000379:methods; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001688:Biological Products; D004224:Diterpenes; D013261:Sterols; D013481:Superoxides; D010196:Pancreatic Elastase