title: Advances in TERS (tip-enhanced Raman scattering) for biochemical applications.
abstract: TERS (tip-enhanced Raman scattering) provides exceptional spatial resolution without any need for labelling and has become a versatile tool for biochemical analysis. Two examples will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c, leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule analysis is discussed, again based on TERS experiments on DNA and RNA, further highlighting the resolution capabilities of this method.
authors: IPHT (Institute for Photonic Technology), Jena, Germany.
authors: Regina
authors: R
authors: Treffer
authors: René
authors: R
authors: Böhme
authors: Tanja
authors: T
authors: Deckert-Gaudig
authors: Katherine
authors: K
authors: Lau
authors: Stephan
authors: S
authors: Tiede
authors: Xiumei
authors: X
authors: Lin
authors: Volker
authors: V
authors: Deckert
mesh_terms: D004247:DNA / Q000032:analysis*; D036103:Nanotechnology / Q000379:methods*; D012313:RNA / Q000032:analysis*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D012313:RNA; D004247:DNA