title: [Increase in NETO2 gene expression is a potential molecular genetic marker in renal and lung cancers].
abstract: Multiple changes in the genome, transcriptome, and proteome are frequent in cancer cells. A search for molecular markers based on DNA, mRNA, or proteins is a main method to develop early specific diagnostics for cancer. While universal markers are still unavailable, similar trends are known for the expression patterns of particular genes in certain epithelial tumors. A bioinformatic screening of transcriptomic databases identified the NETO2 gene as a new potential promising marker of renal cancer. A substantial increase in NETO2 mRNA level was detected in 90% clear-cell renal cell carcinomas, 70% of non-small cell lung cancers, and 50% of papillary renal cancers by real-time PCR. The NETO2 mRNA level was increased to a lesser extent in cervical carcinoma and colon cancer and tended to decrease in cancer of the stomach. The NETO2 gene, which codes for a membrane glycoprotein with an unclear function, was assumed to provide a new promising marker for early diagnosis in renal cancer and non-small cell lung cancer.
authors: N Iu
authors: NIu
authors: Oparina
authors: A F
authors: AF
authors: Sadritdinova
authors: A V
authors: AV
authors: Snezhkina
authors: A A
authors: AA
authors: Dmitriev
authors: G S
authors: GS
authors: Krasnov
authors: V N
authors: VN
authors: Senchenko
authors: N V
authors: NV
authors: Mel'nikova
authors: M S
authors: MS
authors: Belenikin
authors: V A
authors: VA
authors: Lakunina
authors: V A
authors: VA
authors: Veselovskiĭ
authors: O A
authors: OA
authors: Stepanov
authors: A V
authors: AV
authors: Kudriavtseva
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism; D030562:Databases, Protein; D020224:Expressed Sequence Tags / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D017385:Sequence Homology; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C574595:NETO2 protein, human; C539204:NETO2 protein, mouse