title: The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates.
abstract: Enterovirus 71 (EV71) is a major pathogen that causes hand-foot-mouth disease (HFMD). Our previous studies have demonstrated that the complete process of pathogenesis, which may include tissue damage induced by host inflammatory responses and direct tissue damage caused by viral infection, can be observed in the central nervous system (CNS) of animals infected in the laboratory with EV71. Based on these observations, the neuropathogenesis and protein expression profiles in the thalamic tissues of EV71-infected animals were further analyzed in the present study. Changes in protein expression profiles following immunization with the inactivated EV71 vaccine followed by virus challenge were observed and evaluated, and their physiological roles in viral pathogenesis are discussed. Taken together, the results of these experiments provide evidence regarding the neuropathogenesis and molecular mechanisms associated with EV71 infection and identify several protein indicators of pathogenic changes during viral infection.
authors: Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan 650118, PR China.
authors: Huicheng
authors: H
authors: Chen
authors: Ying
authors: Y
authors: Zhang
authors: Erxia
authors: E
authors: Yang
authors: Longding
authors: L
authors: Liu
authors: Yanchun
authors: Y
authors: Che
authors: Jingjing
authors: J
authors: Wang
authors: Hongling
authors: H
authors: Zhao
authors: Donghong
authors: D
authors: Tang
authors: Chenghong
authors: C
authors: Dong
authors: Lixian
authors: L
authors: Yang
authors: Dong
authors: D
authors: Shen
authors: Xi
authors: X
authors: Wang
authors: Yun
authors: Y
authors: Liao
authors: Lichun
authors: L
authors: Wang
authors: Ruixiong
authors: R
authors: Na
authors: Yan
authors: Y
authors: Liang
authors: Qihan
authors: Q
authors: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D029821:Enterovirus A, Human / Q000276:immunology* / Q000472:pathogenicity*; D004769:Enterovirus Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D020869:Gene Expression Profiling; D007114:Immunization; D007249:Inflammation / Q000276:immunology; D008253:Macaca mulatta; D009420:Nervous System / Q000473:pathology / Q000821:virology; D013788:Thalamus / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines