title: Stem cell niches: famished Paneth cells, gluttonous stem cells.
abstract: Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
authors: Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
authors: Tae-Hee
authors: TH
authors: Kim
authors: Ramesh A
authors: RA
authors: Shivdasani
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D007422:Intestines / Q000166:cytology*; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D046912:Multiprotein Complexes; D019879:Paneth Cells / Q000166:cytology / Q000378:metabolism*; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
chemical_list: D046912:Multiprotein Complexes; D011506:Proteins; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases