title: Total synthesis of (±)-pallambins C and D.
abstract: The first total synthesis of (±)-pallambins C and D has been accomplished in a linear 38 step reaction from (±)-Wieland-Miescher ketone. The key conversions are featured as follows: a Grob fragmentation-intramolecular aldol cyclization and a thiourea/palladium-catalyzed carbonylative annulation.
authors: Department of Chemistry, Centre of Novel Functional Molecules, Institute of Molecular Technology for Drug Discovery and Synthesis, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
authors: Xue-Song
authors: XS
authors: Xu
authors: Zhen-Wu
authors: ZW
authors: Li
authors: Yi-Jun
authors: YJ
authors: Zhang
authors: Xiao-Shui
authors: XS
authors: Peng
authors: Henry N C
authors: HN
authors: Wong
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D000447:Aldehydes; D004224:Diterpenes; C576479:pallambin C; C576480:pallambin D; D010165:Palladium; C116609:3-hydroxybutanal; D013890:Thiourea