title: Lipodystrophy and reversal of facial lipoatrophy in perinatally HIV-infected children and adolescents after discontinuation of stavudine.
abstract: Lipodystrophy (LD) was evaluated in 205 children receiving antiretroviral therapy by a single investigator: 51 (24.9%) had LD; 46 peripheral lipoatrophy, three central lipohypertrophy and two combined type. All cases of peripheral and combined LD also had facial lipoatrophy. Serial photographs were provided by the families to confirm the severity of facial lipoatrophy. Forty-six (95.8%) children with peripheral or combined LD, and 75 (48.7%) without LD were exposed to stavudine (d4T) for a median duration of 45.9 versus 26.4 months (P = 0.005). In multivariate analysis, exposure to d4T for more than three months was the only factor associated with peripheral or combined LD (P < 0.001). Noticeable improvement of facial lipoatrophy was found in 11/48 (22.9%) children after a mean duration of 45.6 months following d4T discontinuation, mostly occurring during early adolescence.
authors: Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-noi Bangkok 10700  Thailand.
authors: N
authors: N
authors: Sawawiboon
authors: O
authors: O
authors: Wittawatmongkol
authors: W
authors: W
authors: Phongsamart
authors: W
authors: W
authors: Prasitsuebsai
authors: K
authors: K
authors: Lapphra
authors: K
authors: K
authors: Chokephaibulkit
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D015331:Cohort Studies; D005145:Face / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D018119:Stavudine / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D018119:Stavudine