title: Ovarian ascites-derived Hospicells promote angiogenesis via activation of macrophages.
abstract: Within the microenvironment, Carcinoma-associated mesenchymal stem cells (Hospicells) are able to influence ovarian tumor development via, among others, the facilitation of angiogenesis in the tumor site allowing an accelerated tumor growth. We demonstrate the presence of a chemotactism between endothelial cells and Hospicells, and a cell line specific increased secretion of pro-angiogenic cytokines such as IL-6, IL-8 and VEGF from ovarian adenocarcinoma cells. Hospicells are also able to attract and activate macrophages to a M2 phenotype and allow them to secrete a huge quantity of pro-angiogenic cytokines, favorable to tumor progression of all the associated ovarian adenocarcinoma cells tested.
authors: EA4553, Institut Claudius Regaud, F-31062 Toulouse, France.
authors: Magali
authors: M
authors: Castells
authors: Benoît
authors: B
authors: Thibault
authors: Eliane
authors: E
authors: Mery
authors: Muriel
authors: M
authors: Golzio
authors: Marlene
authors: M
authors: Pasquet
authors: Isabelle
authors: I
authors: Hennebelle
authors: Philippe
authors: P
authors: Bourin
authors: Massoud
authors: M
authors: Mirshahi
authors: Jean Pierre
authors: JP
authors: Delord
authors: Denis
authors: D
authors: Querleu
authors: Bettina
authors: B
authors: Couderc
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001201:Ascites / Q000473:pathology*; D002450:Cell Communication; D002460:Cell Line; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008264:Macrophages / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000502:physiology*; D009389:Neovascularization, Pathologic; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D018874:Spheroids, Cellular; D014407:Tumor Cells, Cultured; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D042461:Vascular Endothelial Growth Factor A