title: Surgical management of gastrointestinal posttransplant lymphoproliferative disorders in liver transplant recipients.
abstract: BACKGROUND
  Posttransplant lymphoproliferative disorder (PTLD) is a well-established complication of immunosuppression. The involvement of the gastrointestinal (GI) tract occurs in 25% of all cases of PTLD. Fortunately, surgical intervention is seldom required. We report our experience of surgical treatment of complicated GI-PTLD after liver transplantation (LTx).
  
  
  METHODS
  A retrospective analysis of 5677 adult patients who underwent LTx between 1983 and 2009 was conducted.
  
  
  RESULTS
  Thirty-six patients presented with GI-PTLD. Sixteen patients presented with complications associated with GI-PTLD requiring emergency surgery. The average (SD) time from LTx to GI surgery was 7.9 (5.8) years (range, 4 months to 17 years). Indications for surgical intervention were small bowel obstruction (seven cases), perforation (six cases), and GI bleeding (three cases). Most GI-PTLD occurred in the small bowel or right colon (81%). In addition to the surgery, treatment of PTLD consisted of reduction of immunosuppression, use of rituximab (n=10), and systemic chemotherapy (n=7). Overall mortality was 69%, with most of the deaths occurring within 8 months after emergency laparotomy. GI bleeding and perforation were associated with higher mortality (>66%). Despite higher early mortality in the surgical group, no differences on long-term outcome were observed between patients with GI-PTLD who required surgery and those who did not (P=0.371).
  
  
  CONCLUSIONS
  In summary, GI-PTLD requiring surgical intervention is an extremely rare condition with high early mortality. Most of the cases are monoclonal, present a late onset, and involve the lower GI tract. Intestinal obstruction is the main indication for surgical intervention and is associated with better prognosis.
authors: Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-3442, USA. ruycruzjunior@yahoo.com.br
authors: Ruy J
authors: RJ
authors: Cruz
authors: Sumana
authors: S
authors: Ramachandra
authors: Eisaburo
authors: E
authors: Sasatomi
authors: Andrea
authors: A
authors: DiMartini
authors: Michael
authors: M
authors: de Vera
authors: Paulo
authors: P
authors: Fontes
authors: Christopher
authors: C
authors: Hughes
authors: Abhinav
authors: A
authors: Humar
mesh_terms: D000293:Adolescent; D000328:Adult; D005767:Gastrointestinal Diseases / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007415:Intestinal Obstruction / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies