title: Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6.
abstract: Cytokines, and specifically interleukin 6 (IL-6) and interleukin 8 (IL-8), have been associated with the pathogenesis of endometriosis. We studied serum concentrations of IL-6 and IL-8 in patients with deep infiltrating endometriosis (DIE) or ovarian endometriomas (OE), but no other forms of associated endometriosis disease type. We carried out a case-control study including 19 patients with OE alone (OE group), 14 patients with DIE alone (DIE group) and 24 healthy patients without endometriosis (C group). Serum concentrations of IL-6 and IL-8 were measured in the three groups of patients. Serum levels of both IL-6 and IL-8 were significantly higher in the OE group. A high positive correlation was found between serum IL-6 and IL-8 levels in the OE group but not in the DIE and C groups. Serum IL-8 alone achieved the highest predictive value of the presence of OE (adjusted OR: 1.44; sensitivity: 78.2%; specificity: 76.2%). The combination of IL-6 and IL-8 levels did not significantly improve the discrimination between subjects with OE and those with DIE over that of IL-8. OE but not DIE are associated with increased serum levels of IL-6 and IL-8, and thus these may become useful tools for discriminating OE alone from DIE.
authors: Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Faculty of Medicine-University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. fcarmona@clinic.ub.es
authors: Francisco
authors: F
authors: Carmona
authors: Charles
authors: C
authors: Chapron
authors: María-Ángeles
authors: MÁ
authors: Martínez-Zamora
authors: Pietro
authors: P
authors: Santulli
authors: Aintzane
authors: A
authors: Rabanal
authors: Mario
authors: M
authors: Martínez-Florensa
authors: Francisco
authors: F
authors: Lozano
authors: Juan
authors: J
authors: Balasch
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D016209:Interleukin-8 / Q000097:blood* / Q000276:immunology; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis / Q000276:immunology
chemical_list: C508606:CXCL8 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8