title: Biliopancreatic diversion with duodenojejunal exclusion associated with truncal vagotomy: a new proposal for type 2 diabetes mellitus treatment.
abstract: OBJECTIVE
  To evaluate the effectiveness of the biliopancreatic diversion surgery with duodenojejunal exclusion in combination with truncal vagotomy in type 2 diabetes mellitus (T2DM) patients with overweight or class I or II obesity.
  
  
  METHODS
  The study included ten patients with T2DM and class I or II obesity or overweight who were subjected to biliopancreatic diversion with duodenojejunal exclusion in combination with truncal vagotomy. The blood glucose levels during the pre- and postoperative periods were compared using the Friedman test. The significance level adopted was 5%.
  
  
  RESULTS
  There were significant differences between preoperative and postoperative blood glucose levels at three months (p=0.01), six months (p=0.001) and 12 months (p=0.001). There was also a significant difference between one month postoperative blood glucose and six months postoperative blood glucose (p=0.01). Glycosylated hemoglobin levels decreased in 80% of patients, there was marked improvement in their lipid profiles, and the average BMI reduction was 7.0±1.5 kg/m² at 12 months after the surgery.
  
  
  CONCLUSIONS
  In patients with type 2 diabetes mellitus associated with class I/II obesity or overweight, performing biliopancreatic diversion with duodenojejunal exclusion in combination with truncal vagotomy resulted in glycemic control, reduction of excess weight, and improvement of lipid profile 12 months after the surgery.
authors: Department of Surgery, Candido Rondon Hospital, Ji-Parana-RO, Brazil.
authors: Edson
authors: E
authors: Alleotti
authors: Rogério Tadeu
authors: RT
authors: Palma
authors: Paulo Engler
authors: PE
authors: Pinto Junior
authors: José Antonio
authors: JA
authors: Bento
authors: Raquel
authors: R
authors: Yonamine
authors: André Luiz Lopes Cardoso
authors: AL
authors: Campos
authors: Jaques
authors: J
authors: Waisberg
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015904:Biliopancreatic Diversion / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003131:Combined Modality Therapy / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000601:surgery*; D004386:Duodenum / Q000601:surgery*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000601:surgery*; D011184:Postoperative Period; D016896:Treatment Outcome; D015167:Vagotomy, Truncal / Q000379:methods*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin