title: What is the role of field-directed therapy in the treatment of actinic keratosis? Part 2: Commonly used field-directed and lesion-directed therapies.
abstract: Actinic keratosis (AK) constitutes the initial epidermal lesion in a disease continuum that may potentially progress to invasive squamous cell carcinoma (SCC). A number of treatment options are available to clear lesions and thus reduce the risk for progression to SCC. Field-directed therapies are primarily used to clear multiple AKs and subclinical lesions. Part 1 of this review explaining the role of field-directed therapy for the treatment of AK discussed the unmet needs with current therapies and the investigational agents that are being developed to fill treatment gaps. Part 2 will mainly focus on field-directed therapies that currently are available for AK, such as resurfacing procedures, patient-administered topical therapy, and photodynamic therapy (PDT), as well as lesion-directed therapy, which is used to clear discrete lesions in relatively small numbers.
authors: The Center for Clinical and Cosmetic Research, Aventura, Florida USA.
authors: Brian
authors: B
authors: Berman
authors: David E
authors: DE
authors: Cohen
authors: Sadegh
authors: S
authors: Amini
mesh_terms: D000279:Administration, Cutaneous; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000517:prevention & control*; D018450:Disease Progression; D006801:Humans; D055623:Keratosis, Actinic / Q000150:complications / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods; D012646:Self Administration; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*