title: Thrombotic risk in patients undergoing peripheral stem cell apheresis and low-molecular weight heparin prophylaxis pre-apheresis.
abstract: Patients undergoing peripheral blood stem cell (PBSC) collection for autologous transplantation may have a greater incidence of thrombosis due to a number of risk factors (RFs). These factors may be related to the patient himself (history of thromboembolism, tumour type and stage, treatment), to the procedure and/or to the mobilizing agents used. In our study of 97 patients, 32 were considered high risk (HR) patients and were therefore treated with a low prophylactic dose of enoxaparin the evening before stem cell apheresis. Neither thrombotic nor hemorrhagic complications were observed, even though pre-apheresis platelet levels were below 50×10(9)l(-1) in 19 procedures.
authors: Transfusion Medicine Service, Azienda Ospedaliera Marche Nord, San Salvatore Hospital, Pesaro, Italy. p.politi@ospedalesansalvatore.it
authors: Patrizia
authors: P
authors: Politi
authors: Suzy M T
authors: SM
authors: Durazzi
authors: Francesco
authors: F
authors: Picardi
mesh_terms: D000328:Adult; D000368:Aged; D001781:Blood Component Removal / Q000009:adverse effects*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D006495:Heparin, Low-Molecular-Weight