title: Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction: Health check-up study of Japanese men.
abstract: OBJECTIVE
  Central obesity, insulin resistance and alcohol consumption are thought to be major risk factors for fatty liver formation. Adiponectin (APN) prevents fatty liver formation, and its serum levels are lower in subjects with central obesity and/or insulin resistance. The aim of this study was to explore the association among serum APN levels, central obesity, insulin resistance and liver dysfunction with or without fatty liver classified by alcohol consumption in healthy subjects.
  
  
  METHODS
  A total of 5588 Japanese male subjects who underwent a health check-up were classified into three groups according to alcohol consumption: non- or light drinkers (15 g/day ≥ ethanol); mild drinkers (15 g/day < ethanol ≤ 30 g/day); and moderate- or heavy drinkers (30 g/day < ethanol). Central obesity and insulin resistance were assessed by waist circumference (WC) and Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), respectively.
  
  
  RESULTS
  WC was significantly increased, while HOMA-IR was significantly decreased according to the extent of alcohol consumption. Serum alanine aminotransferase levels were significantly lower and serum APN levels were significantly higher in mild drinkers than in the other two groups. Multiple linear regression analysis showed that serum APN level served as the significant and independent determinant for liver dysfunction in the subjects with fatty liver, irrespective of alcohol consumption. However, WC became a non-significant determinant of liver dysfunction as alcohol consumption increased.
  
  
  CONCLUSIONS
  Hypoadiponectinemia is a significant determinant for steatotic dysfunction for all levels of alcohol consumption, but central obesity was not a significant determinant for alcoholic fatty liver-induced liver dysfunction.
authors: Departments of Gastroenterology and Hepatology             Molecular Biochemistry and Clinical Investigation             Biomedical Statistics, Osaka University, Graduate School of Medicine, Suita             Sumitomo Hospital, Osaka             Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
authors: Mina
authors: M
authors: Hamano
authors: Yoshihiro
authors: Y
authors: Kamada
authors: Shinichi
authors: S
authors: Kiso
authors: Kunimaro
authors: K
authors: Furuta
authors: Takashi
authors: T
authors: Kizu
authors: Norihiro
authors: N
authors: Chatani
authors: Mayumi
authors: M
authors: Egawa
authors: Takayo
authors: T
authors: Takemura
authors: Hisao
authors: H
authors: Ezaki
authors: Yuichi
authors: Y
authors: Yoshida
authors: Kenji
authors: K
authors: Watabe
authors: Toshimitsu
authors: T
authors: Hamasaki
authors: Miyuki
authors: M
authors: Umeda
authors: Aiko
authors: A
authors: Furubayashi
authors: Kazuo
authors: K
authors: Kinoshita
authors: Osamu
authors: O
authors: Kishida
authors: Takashi
authors: T
authors: Fujimoto
authors: Akira
authors: A
authors: Yamada
authors: Yoshifumi
authors: Y
authors: Tsukamoto
authors: Shusaku
authors: S
authors: Tsutsui
authors: Tetsuo
authors: T
authors: Takehara
authors: Norio
authors: N
authors: Hayashi
authors: Yuji
authors: Y
authors: Matsuzawa