title: Ventilatory threshold is related to walking tolerance in patients with intermittent claudication.
abstract: BACKGROUND
  This study assessed the relationship between lower limb hemodynamics and metabolic parameters with walking tolerance in patients with intermittent claudication (IC).
  
  
  METHODS
  Resting ankle-brachial index (ABI), baseline blood flow (BF), BF response to reactive hyperemia (BFRH), oxygen uptake (VO2), initial claudication distance (ICD) and total walking distance (TWD) were measured in 28 IC patients. Pearson and Spearman correlations were calculated.
  
  
  RESULTS
  ABI, baseline BF and BF response to RH did not correlate with ICD or TWD. VO2 at first ventilatory threshold and VO2peak were significantly and positively correlated with ICD (r = 0.41 and 0.54, respectively) and TWD (r = 0.65 and 0.71, respectively).
  
  
  CONCLUSIONS
  VO2peak and VO2 at first ventilatory threshold, but not ABI, baseline BF and BFHR were associated with walking tolerance in IC patients. These results suggest that VO2 at first ventilatory threshold may be useful to evaluate walking tolerance and improvements in IC patients.
authors: Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors: M
authors: M
authors: da Rocha Chehuen
authors: G
authors: G
authors: Cucato
authors: J
authors: J
authors: Dos Anjos Souza Barbosa
authors: L
authors: L
authors: Costa
authors: R
authors: R
authors: Ritti-Dias
authors: N
authors: N
authors: Wolosker
authors: C
authors: C
authors: de Moraes Forjaz
mesh_terms: D000368:Aged; D015308:Anaerobic Threshold; D055109:Ankle Brachial Index; D001938:Brazil; D005080:Exercise Test; D017079:Exercise Tolerance; D006439:Hemodynamics; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D007383:Intermittent Claudication / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism* / Q000503:physiopathology; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D012123:Pulmonary Ventilation; D012039:Regional Blood Flow; D016138:Walking