title: Interaction of S-methyl methanethiosulfonate with DPPC bilayer.
abstract: The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS) interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid effect on vesicle stability was studied. The results show that MMTS interacts to different extents with the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states. To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design of their mode of action.
authors: INQUINOA-CONICET, Cátedra de Fisicoquímica I, Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Lorenzo 456, T4000CAN S. M. de Tucumán, Argentina.
authors: María E
authors: ME
authors: Defonsi Lestard
authors: Sonia B
authors: SB
authors: Díaz
authors: María E
authors: ME
authors: Tuttolomondo
authors: Santiago
authors: S
authors: Sánchez Cortez
authors: Marcelo
authors: M
authors: Puiatti
authors: Adriana B
authors: AB
authors: Pierini
authors: Aida
authors: A
authors: Ben Altabef
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry*; D008741:Methyl Methanesulfonate / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D009391:Nephelometry and Turbidimetry; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D014732:Vibration
chemical_list: D008051:Lipid Bilayers; D015060:1,2-Dipalmitoylphosphatidylcholine; C014674:methyl methanethiosulfonate; D008741:Methyl Methanesulfonate