title: A 380-kb Duplication in 7p22.3 Encompassing the LFNG Gene in a Boy with Asperger Syndrome.
abstract: De novo genomic aberrations are considered an important cause of autism spectrum disorders. We describe a de novo 380-kb gain in band p22.3 of chromosome 7 in a patient with Asperger syndrome. This duplicated region contains 9 genes including the LNFG gene that is an important regulator of NOTCH signaling. We suggest that this copy number variation has been a contributive factor to the occurrence of Asperger syndrome in this patient.
authors: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: A T
authors: AT
authors: Vulto-van Silfhout
authors: A F M
authors: AF
authors: de Brouwer
authors: N
authors: N
authors: de Leeuw
authors: C C
authors: CC
authors: Obihara
authors: H G
authors: HG
authors: Brunner
authors: B B A
authors: BB
authors: de Vries