title: BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer.
abstract: BRCA1 (breast cancer early-onset 1) alternative splicing levels are regulated in a cell-cycle- and cell-type-specific manner, with splice variants being present in different proportions in tumour cell lines as well as in normal mammary epithelial cells. The importance of this difference in the pathogenesis of breast cancer has yet to be determined. Developing an understanding of the impact of BRCA1 isoform ratio changes on cell phenotype will be of value in breast cancer and may offer therapeutic options. In the present paper, we describe the splicing isoforms of BRCA1 exon 11, their possible role in cancer biology and the importance of maintaining a balanced ratio.
authors: Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
authors: Claudia
authors: C
authors: Tammaro
authors: Michela
authors: M
authors: Raponi
authors: David I
authors: DI
authors: Wilson
authors: Diana
authors: D
authors: Baralle
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans
chemical_list: D019313:BRCA1 Protein