title: New polymer-halloysite hybrid materials--potential controlled drug release system.
abstract: New hybrid materials based on a natural host (halloysite), biodegradable polymer (poly(vinyl alcohol)) and diphenhydramine hydrochloride as drug were synthesized and tested as a potential controlled drug delivery system. The formation of these hybrid materials was proved using different characterization methods like Spectroscopic techniques (FTIR, XPS and UV-vis), thermogravimetrical analysis and scanning electron microscopy (SEM). The hybrid materials exhibit different features regarding the drug release. In vitro drug release tests showed that there are several factors which exhibit a strong influence on the drug release rate. Thus the initial drug concentration used at the hybrid materials synthesis, the presence of a polymer in the hybrid composition and the pH value of the release medium are the most important factors.
authors: Advanced Polymer Materials Group, University Politehnica of Bucharest, 149 Calea Victoriei, 010072 Bucharest, Romania.
authors: Adi
authors: A
authors: Ghebaur
authors: Sorina A
authors: SA
authors: Garea
authors: Horia
authors: H
authors: Iovu
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D000077215:Clay; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004155:Diphenhydramine / Q000737:chemistry*; D016503:Drug Delivery Systems; D006634:Histamine H1 Antagonists / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D000538:Aluminum Silicates; D003692:Delayed-Action Preparations; D006634:Histamine H1 Antagonists; D004155:Diphenhydramine; D011142:Polyvinyl Alcohol; D000077215:Clay