title: Peptides for specific intracellular delivery and targeting of nanoparticles: implications for developing nanoparticle-mediated drug delivery.
abstract: The use of peptides to mediate the delivery and uptake of nanoparticle (NP) materials by mammalian cells has grown significantly over the past 10 years. This area of research has important implications for the development of new therapeutic materials and for the emerging field of NP-mediated drug delivery. In this review, we highlight recent advances in the delivery of various NPs by some of the more commonly employed cellular delivery peptides and discuss important related factors such as NP-peptide bioconjugation, uptake efficiency, intracellular fate and toxicity. We also highlight various demonstrations of therapeutic applications of NP-peptide conjugates where appropriate. The paper concludes with a brief forward-looking perspective discussing what can be expected as this field develops in the coming years.
authors: Center for Bio/Molecular Science & Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA. james.delehanty@nrl.navy.mil
authors: James B
authors: JB
authors: Delehanty
authors: Kelly
authors: K
authors: Boeneman
authors: Christopher E
authors: CE
authors: Bradburne
authors: Kelly
authors: K
authors: Robertson
authors: Jason E
authors: JE
authors: Bongard
authors: Igor L
authors: IL
authors: Medintz
mesh_terms: D000818:Animals; D001692:Biological Transport; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D018014:Gene Transfer Techniques; D006801:Humans; D050997:Nanomedicine / Q000639:trends; D053758:Nanoparticles; D010455:Peptides / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations