title: A DNA-based candidate HIV vaccine delivered via in vivo electroporation induces CD4 responses toward the α4β7-binding V2 loop of HIV gp120 in healthy volunteers.
abstract: Administration of a clade C/B' candidate HIV-1 DNA vaccine, ADVAX, by in vivo electroporation (EP) was safe and more immunogenic than intramuscular administration without EP. The breadth and specificity of T-cell responses to full-length Env were mapped. Responses to multiple Env regions were induced, with most focusing on V3/C4 and V2 regions, including the α4β7 integrin-binding domain. The breadth of responses induced by this DNA vaccine regimen was comparable to that of viral-vectored vaccine regimens.
authors: IAVI Human Immunology Laboratory, Imperial College, London, United Kingdom. j.kopycinski@imperial.ac.uk
authors: Jakub
authors: J
authors: Kopycinski
authors: Hannah
authors: H
authors: Cheeseman
authors: Ambreen
authors: A
authors: Ashraf
authors: Dilbinder
authors: D
authors: Gill
authors: Peter
authors: P
authors: Hayes
authors: Drew
authors: D
authors: Hannaman
authors: Jill
authors: J
authors: Gilmour
authors: Josephine H
authors: JH
authors: Cox
authors: Sandhya
authors: S
authors: Vasan
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018274:Electroporation / Q000379:methods*; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D064368:Healthy Volunteers; D006801:Humans; D007444:Inulin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology; D014611:Vaccination / Q000379:methods; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D015699:HIV Envelope Protein gp120; D019444:Vaccines, DNA; C576871:delta inulin; C514793:gp120 protein, Human immunodeficiency virus 1; D007444:Inulin