title: [Experimental study on animal with automatic drug injection based on predictive control for vascular interventional therapy].
abstract: This paper focuses on the animal experiment of automatic drug delivery based on predictive control for vascular interventional therapy. Improvement of drug delivery system based on predictive control used in simulated experiments was put forward after the presence of time varying parameters and the characteristics of individual differences of animal had been studied. The adaptability of time varying parameters and fault tolerance of the system were also enhanced. Different injection methods were tested on animals. It is proved that higher target blood concentration can be reached while injecting during diastolic than that while injecting during systolic or injecting at a constant speed within the whole cardiac cycle. The results also showed that the improved drug injection system based on predictive control which synchronizes with the cardiac cycle could be applied to clinical trials.
authors: College of Architecture & Environment, Sichuan University, Chengdu 610065, China.
authors: Haiyan
authors: H
authors: Tu
authors: Zhirun
authors: Z
authors: Yuan
authors: Xiaodong
authors: X
authors: Xie
authors: Chaohua
authors: C
authors: Wang
authors: Changwei
authors: C
authors: Zhang
authors: Meixiong
authors: M
authors: Cheng
authors: Feng
authors: F
authors: Fan
authors: Ziyin
authors: Z
authors: Zhang
authors: Hongliang
authors: H
authors: Zhang
mesh_terms: D000465:Algorithms; D000818:Animals; D001331:Automation; D004177:Dipyrone / Q000008:administration & dosage / Q000031:analogs & derivatives; D005544:Forecasting; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013552:Swine
chemical_list: D004364:Pharmaceutical Preparations; D004177:Dipyrone; C008667:noramidopyrine