title: Reduced N400 semantic priming effects in adult survivors of paediatric and adolescent traumatic brain injury.
abstract: The immediate and long-term neural correlates of linguistic processing deficits reported following paediatric and adolescent traumatic brain injury (TBI) are poorly understood. Therefore, the current research investigated event-related potentials (ERPs) elicited during a semantic picture-word priming experiment in two groups of highly functioning individuals matched for various demographic variables and behavioural language performance. Participants in the TBI group had a recorded history of paediatric or adolescent TBI involving injury mechanisms associated with diffuse white matter pathology, while participants in the control group never sustained any insult to the brain. A comparison of N400 Mean Amplitudes elicited during three experimental conditions with varying semantic relatedness between the prime and target stimuli (congruent, semantically related, unrelated) revealed a significantly smaller N400 response in the unrelated condition in the TBI group, indicating residual linguistic processing deviations when processing demands required the quick detection of a between-category (unrelated) violation of semantic expectancy.
authors: Centre for Neurogenic Communication Disorders Research, The University of Queensland, Brisbane, Australia. c.knuepffer@uq.edu.au
authors: C
authors: C
authors: Knuepffer
authors: B E
authors: BE
authors: Murdoch
authors: D
authors: D
authors: Lloyd
authors: F M
authors: FM
authors: Lewis
authors: F J
authors: FJ
authors: Hinchliffe
mesh_terms: D000293:Adolescent; D000328:Adult; D001245:Association Learning / Q000502:physiology*; D020208:Brain Injury, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted; D013067:Speech Perception / Q000502:physiology; D017741:Survivors; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult