title: Epidemiology, mortality rate and survival in a homogeneous population of hypopituitary patients.
abstract: BACKGROUND
  Hypopituitarism is associated with higher prevalence of cardiovascular risk factors and premature death. Furthermore, some clinical and therapeutic features of hypopituitarism have been associated with a worse prognosis.
  
  
  OBJECTIVE
  We reviewed, retrospectively, a large series of adult patients with hypopituitarism using stringent epidemiological criteria. Prevalence, association with cardiovascular risk factors, mortality and survival have been analysed.
  
  
  METHODS
  Two hundred and nine adult hypopituitary patients (56·9% females) from a population of 405 218 inhabitants, followed for 10 years.
  
  
  RESULTS
  Prevalence of hypopituitarism at the end of the study was 37·5 cases/100 000 inhabitants. Incidence of hypopituitarism was 2·07 cases/100 000 inhabitants and year. Thirty-two patients died during the period of the study. Standardized mortality rate (SMR) was 8·05, higher in males (8·92 vs 7·34) and in younger patients (84·93 vs 5·26). Diagnosis of acromegaly (P = 0·033), previous radiotherapy (P = 0·02), higher BMI (P = 0·04), diabetes mellitus (P = 0·03) and cancer (P < 0·0001) were associated with mortality. A lower survival was associated with older age at diagnosis, nontumoural causes, previous radiotherapy, diabetes mellitus with poor metabolic control and malignant disease.
  
  
  CONCLUSIONS
  Prevalence of hypopituitarism was 37·5 cases/100 000 inhabitants, and annual incidence was 2·07 cases/100 000 inhabitants. SMR was 8 times higher in hypopituitarism than in general population and was also higher in males and younger patients. Reduced survival was significantly related to cancer, nontumoural causes of hypopituitarism, older age at diagnosis, previous radiotherapy and diabetes mellitus with poor metabolic control.
authors: Endocrinology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
authors: E
authors: E
authors: Fernandez-Rodriguez
authors: M
authors: M
authors: Lopez-Raton
authors: P
authors: P
authors: Andujar
authors: I M
authors: IM
authors: Martinez-Silva
authors: C
authors: C
authors: Cadarso-Suarez
authors: F F
authors: FF
authors: Casanueva
authors: I
authors: I
authors: Bernabeu
mesh_terms: D000293:Adolescent; D000309:Adrenal Insufficiency; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D006801:Humans; D007018:Hypopituitarism / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D007037:Hypothyroidism; D007986:Luteinizing Hormone; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone