title: [High cholesterol diet modifies the repairing effect of the hepatocyte growth factor].
abstract: Currently, fatty liver represents a serious public health problem in the Western world. In our country, a large amount of food rich in cholesterol is consumed. Cholesterol is an important component in lipid rafts, where many receptors for growth factors are localized, so its functionality could be altered in the presence of high cholesterol concentration. Hepatocyte growth factor (HGF) and its receptor c-Met are known to promote repair after an injury. The aim in the present work was to study the effect of a high cholesterol diet in the molecular repair process mediated by HGF in hepatocytes and liver tissue. Data show a delay in the activation of the HGF-mediated signaling cascade which results in a deficient repair process, that in the case of a continuous aggression could favor the progression of liver damage.
authors: Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa. mcgr@xanum.uam.mx
authors: María Concepción
authors: MC
authors: Gutiérrez Ruiz
authors: Mayra
authors: M
authors: Domínguez Pérez
authors: Sandra
authors: S
authors: Rodríguez González
authors: Natalia
authors: N
authors: Nuño Lámbarri
authors: Cynthia
authors: C
authors: Licona Retama
authors: Luis Enrique
authors: LE
authors: Gómez-Quiroz
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D017228:Hepatocyte Growth Factor / Q000502:physiology*; D051379:Mice
chemical_list: D002791:Cholesterol, Dietary; D017228:Hepatocyte Growth Factor