title: Impaired functional but preserved structural connectivity in limbic white matter tracts in youth with conduct disorder or oppositional defiant disorder plus psychopathic traits.
abstract: Youths with conduct disorder or oppositional defiant disorder and psychopathic traits (CD/ODD+PT) are at high risk of adult antisocial behavior and psychopathy. Neuroimaging studies demonstrate functional abnormalities in orbitofrontal cortex and the amygdala in both youths and adults with psychopathic traits. Diffusion tensor imaging in psychopathic adults demonstrates disrupted structural connectivity between these regions (uncinate fasiculus). The current study examined whether functional neural abnormalities present in youths with CD/ODD+PT are associated with similar white matter abnormalities. Youths with CD/ODD+PT and comparison participants completed 3.0 T diffusion tensor scans and functional magnetic resonance imaging scans. Diffusion tensor imaging did not reveal disruption in structural connections within the uncinate fasiculus or other white matter tracts in youths with CD/ODD+PT, despite the demonstration of disrupted amygdala-prefrontal functional connectivity in these youths. These results suggest that disrupted amygdala-frontal white matter connectivity as measured by fractional anisotropy is less sensitive than imaging measurements of functional perturbations in youths with psychopathic traits. If white matter tracts are intact in youths with this disorder, childhood may provide a critical window for intervention and treatment, before significant structural brain abnormalities solidify.
authors: Department of Clinical Neurological Sciences, Schulich School of Medicine, University of Western Ontario, 339 Windermere Road, London, Ontario, Canada N6A 35A5. Elizabeth.Finger@lhsc.on.ca
authors: Elizabeth Carrie
authors: EC
authors: Finger
authors: Abigail
authors: A
authors: Marsh
authors: Karina Simone
authors: KS
authors: Blair
authors: Catherine
authors: C
authors: Majestic
authors: Iordanis
authors: I
authors: Evangelou
authors: Karan
authors: K
authors: Gupta
authors: Marguerite Reid
authors: MR
authors: Schneider
authors: Courtney
authors: C
authors: Sims
authors: Kayla
authors: K
authors: Pope
authors: Katherine
authors: K
authors: Fowler
authors: Stephen
authors: S
authors: Sinclair
authors: Fernanda
authors: F
authors: Tovar-Moll
authors: Daniel
authors: D
authors: Pine
authors: Robert James
authors: RJ
authors: Blair
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016880:Anisotropy; D000987:Antisocial Personality Disorder / Q000150:complications / Q000473:pathology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000150:complications / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D019955:Conduct Disorder / Q000150:complications / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008032:Limbic System / Q000473:pathology*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D011569:Psychiatric Status Rating Scales