title: Hydrogels in mucosal delivery.
abstract: The concept of mucoadhesion and the molecular design requirements for the synthesis of mucoadhesive agents are both well understood and, as a result, hydrogel formulations that may be applied to mucosal surfaces are readily accessible. Nanosized hydrogel systems that make use of biological recognition or targeting motifs, by reacting to disease-specific environmental triggers and/or chemical signals to affect drug release, are now emerging as components of a new generation of therapeutics that promise improved residence time, faster response to stimuli and triggered release.
authors: School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, POI 2DT, UK.
authors: Hamde
authors: H
authors: Nazar
authors: Marta
authors: M
authors: Roldo
authors: Dimitrios G
authors: DG
authors: Fatouros
authors: Susanna M
authors: SM
authors: van der Merwe
authors: John
authors: J
authors: Tsibouklis
mesh_terms: D000042:Absorption; D000268:Adhesiveness; D000287:Administration, Topical; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D020100:Hydrogels; D009092:Mucous Membrane / Q000378:metabolism*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D004364:Pharmaceutical Preparations