title: [Magnesium metabolism and therapeutic strategy in cardiovascular disease].
abstract: Many epidemiological and clinical analysis have reported the relation between Mg and cardiovascular disease. Hypomagnesemia may be triggering mechanisms for ischemic heart disease, arrhythmias after open heart surgery, serious arrhythmias such as Torsades de Pointes (TdP) , and the negative feed back in congestive heart failure. Supplemental and therapeutic Mg infusion have been reported to reduce the mortality in acute myocardial infarction and having the cardioprotective effect after infarction (controversial) . It is also reported to reduce the incidence of arrhythmias after heart surgery, terminate the serious arrhythmias such as TdP, and improve the negative feed back in congestive heart failure. Magnesium metabolisms in cardiovascular disease are not necessarily clear. We expect the precise analysis of Mg actions and attractive Mg therapy in clinical literature.
authors: Pediatric cardiology, Saitama Children's Medical Center, Japan.
authors: Kenji
authors: K
authors: Hoshino
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D006348:Cardiac Surgical Procedures; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D053565:Hypercalciuria / Q000150:complications; D008274:Magnesium / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D009397:Nephrocalcinosis / Q000150:complications; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications; D016171:Torsades de Pointes / Q000209:etiology / Q000517:prevention & control
chemical_list: D008274:Magnesium