title: [Economic effectiveness of vaccination against rotavirus infection in the Russian Federation].
abstract: OBJECTIVE
  Perform pharmacoeconomic analysis of the effectiveness of implementation of vaccination program against rotavirus infection in the Russian Federation.
  
  
  METHODS
  Cost-benefit analytical method was used for the evaluation of economic effectiveness of vaccination against rotavirus infection in the Russian Federation. The number of early vaccinated--1 800 000 individuals, the number of rotavirus enteritis cases in 0 - 5 age cohort--166 215, were determined. The effectiveness of vaccination against rotavirus gastroenteritis was adopted from ATP (according-to-protocol) clinical trial data and was 83.8% cases at a 95% vaccination level. The cost of a case of rotavirus infection according to calculations in the Russian Federation is 17 394 RUB (Russian rubles), and the cost of vaccination of 1 child--1000 RUB.
  
  
  RESULTS
  The cost of realization of program of vaccination against rotavirus infection would be 1.7 billion RUB per year. The number of prevented cases of rotavirus infection per year in the cohort of children aged up to 5 years would be 148 114. Net benefit of vaccination of newborn children in the Russian Federation would be 866 million RUB.
  
  
  CONCLUSIONS
  Implementation of program of vaccination against rotavirus infection in the Russian Federation would promote the decrease of morbidity and economical efficiency. The cost of vaccination program is 1.5 times less than the amount of expenses related to infection.
authors: M P
authors: MP
authors: Kostinov
authors: V V
authors: VV
authors: Zverev
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D007223:Infant; D007902:Length of Stay; D008297:Male; D008432:Mathematical Computing; D012401:Rotavirus / Q000187:drug effects / Q000502:physiology; D012400:Rotavirus Infections / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000191:economics*; D012426:Russia / Q000453:epidemiology; D014611:Vaccination / Q000191:economics*
chemical_list: D022243:Rotavirus Vaccines