title: [Comparative study of Radix Hedyseri as sulstitute for Radix Astragali of yupingfeng oral liquid on cellular immunity in immunosuppressed mice].
abstract: OBJECTIVE
  To study on Radix Hedyseri as substitute for Radix Astragali of Yupingfeng oral liquid on cellular immunity in immunosuppressed mice.
  
  
  METHODS
  The model of immunosuppression mice were induced by Cyclophosphamide. And the same dose of Radix Hedyseri and Radix Astragali alternative Yupingfeng oral liquid was intragastric administrated into mice; Antagonistic experiments were observed in vivo. Determined the thymus gland index, spleen index, phagocytosis of the macrophage, proliferation index of T lymphocyte, kill and wound activity, T lymphocyte subgroup, and content of IL-13 of serum.
  
  
  RESULTS
  Yupingfeng oral liquid and Yuping-feng aqueous extract of Radix Hedyseri substitute Radix Astragali both could significant raise thymus gland index and spleen index, and clearly increase the phagocytosis of the macrophage. They both could antagonize immunosuppressive action caused by Cyclophosphamide, which could promote T lymphocyte proliferation, kill and wound activity, quantity of T lymphocyte subgroup, and production of IL-1beta with different degree. And Yupingfeng aqueous extract of Radix Hedyseri substitute Radix Astragali increased spleen index and T lymphocyte proliferation was better than those of Yupingfeng oral liquid.
  
  
  CONCLUSIONS
  Radix Hedyseri and Radix Saposhnikoviae, compatible with Rhizoma Atractylodis Macrocephalae compared with Yupingfeng oral liquid in cell immunity regulation has a similar role, and better in the recovery of spleen weight and T cell proliferation.
authors: Institute of Integrated Chinese and Western Medicine, Lanzhou University, Lanzhou 730000, China. zhanglf@lzu.edu.cn
authors: Li-feng
authors: LF
authors: Zhang
authors: Wei-dong
authors: WD
authors: Cheng
authors: Man-man
authors: MM
authors: Gui
authors: Xue-yan
authors: XY
authors: Li
authors: Dong-feng
authors: DF
authors: Wei
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D020014:K562 Cells; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; C532967:yupingfeng; D003520:Cyclophosphamide