title: Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.
abstract: Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.
authors: Department of Cell Biology and Genetics, Cancer Genomics Centre, Erasmus Medical Centre, Rotterdam, The Netherlands.
authors: Berina
authors: B
authors: Eppink
authors: Przemek M
authors: PM
authors: Krawczyk
authors: Jan
authors: J
authors: Stap
authors: Roland
authors: R
authors: Kanaar
mesh_terms: D053903:DNA Breaks, Double-Stranded / Q000187:drug effects; D004260:DNA Repair; D049914:DNA Repair-Deficiency Disorders / Q000209:etiology*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D018869:Heat-Shock Response; D059765:Homologous Recombination / Q000502:physiology; D006801:Humans; D006979:Hyperthermia, Induced; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors
chemical_list: D018841:HSP90 Heat-Shock Proteins; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1