title: Fluid consumption in lithium-treated rats: roles of stimulus novelty and context novelty.
abstract: In 5 experiments thirsty rats received an injection of lithium chloride or of saline, and their consumption of fluid was monitored at 5-min intervals for 30 min. The novelty of the fluid and the novelty of the test context was varied. In Experiment 1 a novel fluid (a sucrose solution) was offered in a novel context; in Experiment 2 the fluid was novel and the context was familiar (the home cage); in Experiment 3 the fluid was familiar and the context was novel; and in Experiment 4 both fluid and context were familiar. Lithium influenced fluid consumption in those designs that included at least one novel feature (Experiments 1, 2, and 3, but not in Experiment 4). Consumption was initially enhanced (with respect to the controls) when the context was novel, but was suppressed when the fluid was novel. In Experiment 5, the flavor was over-ingested after lithium treatment when it was presented in a short (5 min) test conducted in a novel place, but was rejected in a subsequent consumption in the home cages. It is argued that the effect of lithium depends on two factors: enhanced attention to salient cues that modifies the exploratory responses evoked by a novel context; rapid conditioning of an aversion when the fluid consumed is novel. Implications for the use of fluid consumption as an index of lithium-induced nausea are considered.
authors: Faculty of Education and Humanities, University of Granada, Ceuta 51002, Spain. marcial@ugr.es
authors: Marcial
authors: M
authors: Rodríguez
authors: Zoé
authors: Z
authors: García
authors: Pablo
authors: P
authors: Cobo
authors: Geoffrey
authors: G
authors: Hall
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003259:Consummatory Behavior / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004777:Environment; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D055809:Illness Behavior / Q000187:drug effects / Q000502:physiology; D018021:Lithium Chloride / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology; D012055:Reinforcement Schedule; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects; D014867:Water; D014868:Water Deprivation / Q000502:physiology
chemical_list: D018692:Antimanic Agents; D014867:Water; D013395:Sucrose; D018021:Lithium Chloride