title: Acute effect of Aloe vera gel extract on experimental models of pain.
abstract: The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central.
authors: Department of Pharmacology, University College of Medical Sciences (University of Delhi), Delhi 110095, India.
authors: Naveen
authors: N
authors: Rathor
authors: Ashish K
authors: AK
authors: Mehta
authors: Amit K
authors: AK
authors: Sharma
authors: Pramod K
authors: PK
authors: Mediratta
authors: Krishna K
authors: KK
authors: Sharma
mesh_terms: D000504:Aloe; D000818:Animals; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D004643:Emollients / Q000627:therapeutic use; D005557:Formaldehyde; D005782:Gels / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D023421:Models, Animal; D059225:Nociception / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D004643:Emollients; D005782:Gels; D010936:Plant Extracts; D005557:Formaldehyde