title: C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome.
abstract: Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, College of Medicine, Korea University, Seoul, Korea.
authors: Kyung Mook
authors: KM
authors: Choi
authors: Soon Young
authors: SY
authors: Hwang
authors: Ho Cheol
authors: HC
authors: Hong
authors: Sae Jeong
authors: SJ
authors: Yang
authors: Hae Yoon
authors: HY
authors: Choi
authors: Hye Jin
authors: HJ
authors: Yoo
authors: Kwan Woo
authors: KW
authors: Lee
authors: Moon Suk
authors: MS
authors: Nam
authors: Yong Soo
authors: YS
authors: Park
authors: Jeong Taek
authors: JT
authors: Woo
authors: Young Seol
authors: YS
authors: Kim
authors: Dong Seop
authors: DS
authors: Choi
authors: Byung-Soo
authors: BS
authors: Youn
authors: Sei Hyun
authors: SH
authors: Baik
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D050171:Dyslipidemias / Q000209:etiology; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009765:Obesity / Q000209:etiology; D011236:Prediabetic State / Q000097:blood* / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D048069:Tumor Necrosis Factors / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D015415:Biomarkers; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D048069:Tumor Necrosis Factors; D000099174:Pigment Epithelium-Derived Factor; C506069:C1QTNF3 protein, human