title: Metabolomic investigation of Mytilus galloprovincialis (Lamarck 1819) caged in aquatic environments.
abstract: Environmental metabolomics was applied to assess the metabolic responses in transplanted mussels to environmental pollution. Specimens of Mytilus galloprovincialis, sedentary filter-feeders, were caged in anthropogenic-impacted and reference sites along the Augusta coastline (Sicily, Italy). Chemical analysis revealed increased levels of PAHs in the digestive gland of mussels from the industrial area compared with control, and marked morphological changes were also observed. Digestive gland metabolic profiles, obtained by 1H NMR spectroscopy and analyzed by multivariate statistics, showed changes in metabolites involved in energy metabolism. Specifically, changes in lactate and acetoacetate could indicate increased anaerobic fermentation and alteration in lipid metabolism, respectively, suggesting that the mussels transplanted to the contaminated field site were suffering from adverse environmental condition. The NMR-based environmental metabolomics applied in this study results thus in it being a useful and effective tool for assessing environmental influences on the health status of aquatic organisms.
authors: Department of Animal Biology and Marine Ecology, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
authors: Salvatore
authors: S
authors: Fasulo
authors: Francesco
authors: F
authors: Iacono
authors: Tiziana
authors: T
authors: Cappello
authors: Carmelo
authors: C
authors: Corsaro
authors: Maria
authors: M
authors: Maisano
authors: Alessia
authors: A
authors: D'Agata
authors: Alessia
authors: A
authors: Giannetto
authors: Elena
authors: E
authors: De Domenico
authors: Vincenzo
authors: V
authors: Parrino
authors: Giuseppe
authors: G
authors: Lo Paro
authors: Angela
authors: A
authors: Mauceri
mesh_terms: D000818:Animals; D004784:Environmental Monitoring; D055432:Metabolomics; D049878:Mytilus / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D012802:Sicily; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical