title: Direct recordings in human cortex reveal the dynamics of gamma-band [50-150 Hz] activity during pursuit eye movement control.
abstract: The time course of neural activity in human brain regions involved in mediating pursuit eye movements is unclear. To address this question, we recorded intracerebral electroencephalography activity in eight epileptic patients while they performed a pursuit task that dissociates reactive, predictive and inhibited pursuits. A sustained gamma band (50-150 Hz) activity corresponding to pursuit maintenance was observed in the pursuit (and not saccade) area of the frontal eye field (FEF), in the ventral intraparietal sulcus (VIPS) and in occipital areas. The latency of gamma increase was found to precede target onset in FEF and VIPS, suggesting that those areas could also be involved during pursuit preparation/initiation. During pursuit inhibition, a sustained gamma band response was observed within prefrontal areas (pre-supplementary-motor-area, dorso-lateral prefrontal and frontopolar cortex). This study describes for the first time the dynamics of the neural activity in four areas of the pursuit system, not previously available in humans. These findings provide novel timing constraints to current models of the human pursuit system and establish the relevance of direct recordings to precisely relate eye movement behavior with neural activity in humans.
authors: UMR 7152, CNRS-Collège de France, Laboratoire de Physiologie de Perception et de l'Action, Paris, France. julien.bastin@ujf-grenoble.fr
authors: Julien
authors: J
authors: Bastin
authors: Pierre
authors: P
authors: Lebranchu
authors: Karim
authors: K
authors: Jerbi
authors: Philippe
authors: P
authors: Kahane
authors: Guy
authors: G
authors: Orban
authors: Jean-Philippe
authors: JP
authors: Lachaux
authors: Alain
authors: A
authors: Berthoz
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D058256:Brain Waves; D002540:Cerebral Cortex / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology*; D056228:Feedback, Sensory; D005260:Female; D006801:Humans; D008297:Male; D009039:Motion Perception; D012438:Saccades; D055815:Young Adult