title: Stable cystatin C serum levels confirm normal renal function in patients with dronedarone-associated increase in serum creatinine.
abstract: Dronedarone is a new antiarrhythmic drug for patients with nonpermanent atrial fibrillation (AF). A relatively consistent finding in all trials studying dronedarone was a moderate but significant elevation of serum creatinine. Since dronedarone competes for the same organic cation transporter in the distal renal tubule with creatinine, serum creatinine and its derived estimated glomerular filtration rate might not reflect true renal function in patients on dronedarone. We therefore investigated alternative markers for renal function in these patients. We prospectively included 20 patients with nonpermanent AF in whom dronedarone 400 mg twice daily was started. Patients had normal renal function and serum creatinine; serum cystatin C and creatinine clearance were measured before treatment and 10 and 90 days after treatment started. Mean serum creatinine level for all 20 patients at baseline (day 0) was 84.55 ± 12.14 and 87.8 ± 17.59 µmol/L on day 10. This slight increase in all patients was not significant. Patients were now divided into the predefined groups of "increased creatinine" (increase in serum creatinine level > 1 standard deviation) and "not increased creatinine." Patients with increased creatinine levels (n = 5) showed a significant elevation of serum creatinine levels from day 0 to day 10 (82.4 ± 9.18 to 104.4 ± 12.74 µmol/L; P = .003), whereas change in serum creatinine levels in the not increased creatinine group (n = 15) was not significant. Serum cystatin C levels remained stable in both of these groups (increased creatinine group: 0.76 ± 0.08 to 0.78 ± 0.08 mg/L; P = .65; not increased creatinine group: 0.77 ± 0.108 to 0.77 ± 0.107 mg/L; P = .906). In conclusion, cystatin C represents an easily available and reliable biomarker for estimation of true renal function in patients on dronedarone treatment.
authors: Department of Cardiovascular Medicine, Hannover Medical School, D-30625 Hannover, Germany. duncker.david@mh-hannover.de
authors: David
authors: D
authors: Duncker
authors: Hanno
authors: H
authors: Oswald
authors: Ajmal
authors: A
authors: Gardiwal
authors: Ulrich
authors: U
authors: Lüsebrink
authors: Thorben
authors: T
authors: König
authors: Hendrik
authors: H
authors: Schreyer
authors: Gunnar
authors: G
authors: Klein
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000097:blood*; D000077764:Dronedarone; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology*; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D055550:Protein Stability; D015203:Reproducibility of Results; D015854:Up-Regulation / Q000502:physiology
chemical_list: D000889:Anti-Arrhythmia Agents; D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D003404:Creatinine; D000077764:Dronedarone; D000638:Amiodarone