title: From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers.
abstract: Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting.
authors: Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors: Fariz
authors: F
authors: Nurwidya
authors: Fumiyuki
authors: F
authors: Takahashi
authors: Kunihiko
authors: K
authors: Minakata
authors: Akiko
authors: A
authors: Murakami
authors: Kazuhisa
authors: K
authors: Takahashi