title: The association of TGF-β1 codon 10 polymorphism with suicide behavior.
abstract: Many risk factors have been identified for suicide behavior and although a role for cytokines has been suggested in specific psychiatric conditions and suicide behavior, this role is not well-defined. Since some polymorphisms can alter the expression of cytokines, in this study we attempted to assess the role of TGF-β1 codon 10 (T/C) polymorphisms (rs1982073) in suicide behavior. A total of 145 individuals with suicide behavior as well as 200 control participants (without any history of suicide behavior) were included in the study. TGF-β1 codon 10 polymorphism was determined using allele-specific oligonucleotide polymerase chain reaction. Our results demonstrated that the TGF-β1 codon 10 T/T genotype was significantly more prevalent in individuals with suicide behavior (41.7%), in comparison with the controls (27%). The findings of this study demonstrated an association between TGF-β1 (codon 10) T/C polymorphisms and suicide behavior.
authors: Faculty of Medicine, Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. davood_omrani@yahoo.co.uk
authors: Mir Davood
authors: MD
authors: Omrani
authors: Morteza
authors: M
authors: Bagheri
authors: Behzad
authors: B
authors: Bushehri
authors: Faezeh
authors: F
authors: Azizi
authors: Mohamad-Reza
authors: MR
authors: Anoshae
mesh_terms: D003062:Codon; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D059020:Suicidal Ideation; D013405:Suicide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D003062:Codon; D053773:Transforming Growth Factor beta1