title: Evaluation of laryngopharyngeal reflux in pediatric patients with asthma using a new technique of pharyngeal pH-monitoring.
abstract: There is a debate about the association between asthma and gastroesophageal and/or laryngopharyngeal reflux (LPR). Pharyngeal pH-monitoring is a new technique that allows a physician to assess whether reflux passes the upper esophageal sphincter barrier. The aim of the study was to assess the prevalence of LPR in children with difficult-to-treat asthma. The present study was an open, prospective one. A total of 21 subjects of the mean age 12.7 years were enrolled in the study. All children were asked to fill out a Reflux Symptoms Index questionnaire and a 24-h pharyngeal pH monitoring was performed, using the Dx-pH Measurement System. The LPR was diagnosed in 13 (61.9%) children. There was a positive correlation between LPR diagnosis and the degree of asthma control. The LPR was more frequent in children treated with a higher than lower doses of fluticasone (p = 0.019, OR = 17.3) and in those using montelukast compared with non-users (p = 0.008, OR = 19.0). The mean Reflux Symptoms Index score was almost twice greater in children with LPR than in those without it (13.2 vs. 6.8, respectively, p = 0.003). We conclude that the prevalence of laryngopharyngeal reflux in children with difficult-to-treat asthma is substantial.
authors: Department of Pediatric Gastroenterology and Nutrition, Warsaw Medical University, Warsaw, Poland. aleksandra.banaszkiewicz@gmail.com
authors: A
authors: A
authors: Banaszkiewicz
authors: L
authors: L
authors: Dembinski
authors: A
authors: A
authors: Zawadzka-Krajewska
authors: M
authors: M
authors: Dziekiewicz
authors: P
authors: P
authors: Albrecht
authors: M
authors: M
authors: Kulus
authors: A
authors: A
authors: Radzikowski
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications*; D002648:Child; D050782:Esophageal pH Monitoring; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000453:epidemiology*; D008297:Male; D015995:Prevalence