title: Exercise in the metabolic syndrome.
abstract: The metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and hypertension that is occurring in increasing frequency across the global population. Although there is some controversy about its diagnostic criteria, oxidative stress, which is defined as imbalance between the production and inactivation of reactive oxygen species, has a major pathophysiological role in all the components of this disease. Oxidative stress and consequent inflammation induce insulin resistance, which likely links the various components of this disease. We briefly review the role of oxidative stress as a major component of the metabolic syndrome and then discuss the impact of exercise on these pathophysiological pathways. Included in this paper is the effect of exercise in reducing fat-induced inflammation, blood pressure, and improving muscular metabolism.
authors: Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, Canada.
authors: Saeid
authors: S
authors: Golbidi
authors: Azam
authors: A
authors: Mesdaghinia
authors: Ismail
authors: I
authors: Laher
mesh_terms: D000273:Adipose Tissue / Q000473:pathology / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000473:pathology / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress