title: Is there diversity among UGT1A1 polymorphism in Japan?
abstract: OBJECTIVE
  To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan.
  
  
  METHODS
  We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi (southern part of Japan) and Akita (northern part of Japan) prefectures. Blood samples (7 mL) were collected from each participant and stored in EDTA for subsequent genotyping by fragment size analysis, direct sequencing and TaqMan assay of UGT1A1*28, UGT1A7*3/UGT1A9*22 and UGT1A1*93/UGT1A1*6/UGT1A1*27/UGT1A1*60/UGT1A7 (-57), respectively.
  
  
  RESULTS
  The only statistically significant differences in allele polymorphisms among the group examined were for UGT1A1*6. The Akita population showed more UGT1A1*6 heterozygosity (P = 0.0496).
  
  
  CONCLUSIONS
  Our study revealed no regional diversity among UGT1A1, UGT1A7 or UGT1A9 polymorphisms in Japan.
authors: Michiya Kobayashi, Ken Okamoto, Hiromichi Maeda, Department of Human Health and Medical Sciences, Kochi Medical School, Nankoku 783-8505, Japan.
authors: Michiya
authors: M
authors: Kobayashi
authors: Shoichi
authors: S
authors: Hazama
authors: Kenichi
authors: K
authors: Takahashi
authors: Koji
authors: K
authors: Oba
authors: Naoko
authors: N
authors: Okayama
authors: Mitsuaki
authors: M
authors: Nishioka
authors: Yuji
authors: Y
authors: Hinoda
authors: Masaaki
authors: M
authors: Oka
authors: Ken
authors: K
authors: Okamoto
authors: Hiromichi
authors: H
authors: Maeda
authors: Daisuke
authors: D
authors: Nakamura
authors: Junichi
authors: J
authors: Sakamoto
authors: Hideyuki
authors: H
authors: Mishima