title: Targeted magnetic hyperthermia.
abstract: Many nanotechnologies, which enable unique approaches to treat cancer, have been developed based upon non-toxic organic and inorganic materials to improve current cancer treatments. The use of inorganic materials to form magnetic nanoparticles for hyperthermia therapy is of great interest for localized treatment of cancers without effecting adjacent healthy tissue. Extensive clinical trials have begun using magnetic hyperthermia in animal models. The purpose of this article is to address different factors that affect targeting, heating and biodistribution to safely control the therapeutic efficacy of targeted magnetic hyperthermia. This method involves accumulation of magnetic nanoparticles at a tumor site and then manipulating the magnetic properties of the nanoparticles to heat the targeted tissues.
authors: School of Materials Science and Engineering, Clemson University, 161 Sirrine Hall, Clemson, SC 29634, USA.
authors: Roland
authors: R
authors: Stone
authors: Thomas
authors: T
authors: Willi
authors: Yitzhak
authors: Y
authors: Rosen
authors: Olin Thompson
authors: OT
authors: Mefford
authors: Frank
authors: F
authors: Alexis
mesh_terms: D001682:Biological Availability; D055598:Chemical Phenomena; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy