title: Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy.
abstract: It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.
authors: Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France.
authors: Pierre-Emmanuel
authors: PE
authors: Joubert
authors: Scott
authors: S
authors: Werneke
authors: Claire
authors: C
authors: de la Calle
authors: Florence
authors: F
authors: Guivel-Benhassine
authors: Alessandra
authors: A
authors: Giodini
authors: Lucie
authors: L
authors: Peduto
authors: Beth
authors: B
authors: Levine
authors: Olivier
authors: O
authors: Schwartz
authors: Deborah
authors: D
authors: Lenschow
authors: Matthew L
authors: ML
authors: Albert
mesh_terms: D018354:Alphavirus Infections / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000502:physiology*; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D051379:Mice; D008954:Models, Biological; D018384:Oxidative Stress