title: Enhanced behavioral response to serotonin-related agonists in postweaning protein malnourished mice.
abstract: We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A) receptor agonist 8-hydroxy-N,N-dipropyl-2-aminoteralin (8-OH-DPAT) and the 5-HT releaser d-fenfluramine. The number of head weaving responses induced by 8-OH-DPAT or d-fenfluramine in the PM mice was significantly increased compared with the control diet group. The effects of 8-OH-DPAT and d-fenfluramine were blocked by pretreatment with the selective 5-HT(1A) receptor antagonist WAY-100635 (0.01 mg/kg). However, postpubertal (56 d of age) mice fed with the PM diet did not show an enhancement of the 8-OH-DPAT-induced head weaving response. These results indicate the occurence of a supersensitivity of postsynaptic 5-HT(1A) receptor in the postweaning PM group. Moreover, they highlight the postweaning stage as a vulnerable period to malnutrition-induced alterations in central serotonergic systems.
authors: Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4–4–1 Komatsushima, Aoba-ku, Sendai 981–8558, Japan.
authors: Shoko
authors: S
authors: Sato
authors: Osamu
authors: O
authors: Nakagawasai
authors: Takafumi
authors: T
authors: Hayashi
authors: Atsuko
authors: A
authors: Oikawa
authors: Fukie
authors: F
authors: Yaoita
authors: Koichi
authors: K
authors: Tan-No
authors: Takeshi
authors: T
authors: Tadano
authors: Tsuneyoshi
authors: T
authors: Suzuki
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D004044:Dietary Proteins; D005277:Fenfluramine / Q000494:pharmacology; D008297:Male; D044342:Malnutrition / Q000503:physiopathology*; D051379:Mice; D044282:Receptor, Serotonin, 5-HT1A / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D004044:Dietary Proteins; D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D005277:Fenfluramine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin