title: Water-soluble adsorbent β-cyclodextrin-grafted polyethyleneimine for removing bilirubin from plasma.
abstract: A water-soluble adsorbent was developed for removing bilirubin from the plasma of hyperbilirubinemia patient. The adsorbent was synthesized by grafting β-cyclodextrin (β-CD) to branched polyethyleneimine (PEI) matrix. The resulting β-CD-PEI polymer had an average molecular weight of 163.7 kD, and it contained 56.3 β-CD functional groups. In β-CD-PEI-spiked dialysis, 35.8% of plasma bilirubin was removed, which was higher than that removed by the same concentration of bovine serum albumin. β-CD-PEI also removed aromatic amino acids and bile acids. The results indicated that β-CD-PEI could be an effective adsorbent for blood purification application aiming at the removal of toxins.
authors: School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
authors: Zhi
authors: Z
authors: Wang
authors: Houliang
authors: H
authors: Wei
authors: Lingyun
authors: L
authors: Jia
authors: Li
authors: L
authors: Xu
authors: Chunyi
authors: C
authors: Zou
authors: Jian
authors: J
authors: Xie
mesh_terms: D000327:Adsorption; D000818:Animals; D001663:Bilirubin / Q000097:blood* / Q000737:chemistry* / Q000302:isolation & purification; D002417:Cattle; D003956:Dialysis / Q000379:methods*; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000628:therapy; D011094:Polyethyleneimine / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D011094:Polyethyleneimine; D001663:Bilirubin