title: Anticholinesterase-induced symptoms improved by pacemaker implantation in patients with Alzheimer's disease: analysis of 6 cases.
abstract: Herein we describe 6 cases of patients with Alzheimer's disease presented with syncope, dizziness, and dyspnea soon after the initiation of cholinesterase inhibitor therapy. All patients had bradyarrhythmia on electrocardiogram (ECG). Two patients had complete atrioventricular block, 2 pateints had 2/1 type atrioventricular block, 1 patient had sinus bradycardia and hypersensitive carotid sinus syndrome, and 1 had sick sinus syndrome. All these patients were treated with pacemaker implantation and the cholinesterase inhibitor therapy continued. At 13-month follow-up, no syncope, dizziness, or dyspnea was reported.
authors: Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.
authors: Damirbek
authors: D
authors: Osmonov
authors: Kazim Serhan
authors: KS
authors: Özcan
authors: Izzet
authors: I
authors: Erdinler
authors: Servet
authors: S
authors: Altay
authors: Ceyhan
authors: C
authors: Turkkan
authors: Ersin
authors: E
authors: Yildirim
authors: Kadir
authors: K
authors: Gurkan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D054537:Atrioventricular Block / Q000139:chemically induced / Q000628:therapy*; D001919:Bradycardia / Q000139:chemically induced / Q000628:therapy*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D013575:Syncope / Q000139:chemically induced / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors