title: Accurate delivery of chemicals and intense light on infected areas only for targeted therapy inside the body.
abstract: Bacteria and virus deactivation is performed inside and on the skin of the body using the novel device described in this paper. This device delivers on the infected spot only the needed amount of drug and light necessary for therapy, while the excess is siphoned out, thus eliminating the deleterious affects that maybe caused by intravenous injection. A charged coupled device provides means for visual monitoring of the therapeutic reaction and an LED or laser diode supplies the intense light for the photochemical deactivation. The spectra and kinetics of the photochemical reaction that generate the reactive species, such as 1O2 and OH radicals that are responsible for pathogen deactivation, are presented. Topical therapy experiments on New Zealand rabbits are described.
authors: Key Laboratory for Laser Plasmas (Ministry of Education), Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China. jiec@sjtu.edu.cn
authors: Jie
authors: J
authors: Chen
authors: Thomas C
authors: TC
authors: Cesario
authors: Peter M
authors: PM
authors: Rentzepis
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy; D016503:Drug Delivery Systems; D006801:Humans; D007834:Lasers; D010778:Photochemotherapy / Q000379:methods*; D011817:Rabbits; D014777:Virus Diseases / Q000188:drug therapy