title: Prognostic impact of lymphadenectomy in uterine serous cancer.
abstract: OBJECTIVE
  To estimate the survival impact of lymphadenectomy in women diagnosed with uterine serous cancer.
  
  
  METHODS
  Women with a diagnosis of uterine serous cancer were identified from the Surveillance, Epidemiology and End Results Program (SEER) from 1988 to 2007. Only surgically treated women were included.
  
  
  METHODS
  The Surveillance, Epidemiology and End Results Program database provided data from 17 registries.
  
  
  METHODS
  The study population comprised 4178 women.
  
  
  METHODS
  Statistical analyses using Student's t-test, Kaplan-Meier survival methods and Cox proportional hazards regression were performed.
  
  
  METHODS
  Overall survival.
  
  
  RESULTS
  Three thousand, one hundred and ninety-four (67.7%) women underwent lymphadenectomy. Older women (≥65 years) and Caucasian women (relative to Asian) were less likely to have lymphadenectomy (P < 0.001). The prevalence of nodal metastasis in women having lymphadenectomy was 32%. Of the 1997 women who had disease grossly confined to the uterus and underwent lymphadenectomy, 387 (19%) were found to have nodal metastasis. Lymphadenectomy was associated with improved survival; women who underwent lymphadenectomy were 41% (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.54-0.64; P < 0.001) less likely to die than women who did not have the procedure. Moreover, more extensive lymphadenectomy correlated positively with survival. Compared with women with 1-10 nodes removed, those with more extensive lymphadenectomy (>10 nodes removed) were 26% (HR, 0.74; 95% CI, 0.67-0.83; P < 0.001) less likely to die. The impact of the extent of lymphadenectomy on survival was significant in both node-negative and node-positive women.
  
  
  CONCLUSIONS
  Age and race influenced the prevalence of lymphadenectomy in our cohort. This study suggests that the extent of lymphadenectomy is associated with significant improvement in survival of women with uterine serous cancer.
authors: Department of Obstetrics and Gynecology, University of Washington School of Medicine, 1959 Pacific NE, Seattle, WA 98195, USA. mahdih6281@gmail.com
authors: H
authors: H
authors: Mahdi
authors: S
authors: S
authors: Kumar
authors: Z
authors: Z
authors: Al-Wahab
authors: R
authors: R
authors: Ali-Fehmi
authors: A R
authors: AR
authors: Munkarah
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision / Q000401:mortality*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*