title: Impulse oscillometry; therapeutic  impacts of transdermal long-acting Beta-2 agonist patch in elderly asthma with inhaled  corticosteroid alone.
abstract: Growing interest had been focused on the involvement of the small airways in asthma, and impulse oscillometry (IOS) has been utilized as pulmonary functions for detecting large and small airways diseases separately. IOS can measure respiratory resistance and reactance at multiple frequencies, not available by spirometry or body plethysmography, is non-invasive techniques and convenient for elderly patients with a low dependency on cooperation during tidal breathing. IOS indices were well correlated with not only predicted FEV1 but also FEF25-75, residual volume/total lung capacity, delta N2 of a single nitrogen washout test which representing air trapping and inhomogeneous ventilation in the distal lung. These parameters and QOL scores were improved by additional transdermal long-acting beta-2 agonist patch even in well-controlled elderly asthma treating with inhaled corticosteroids alone. IOS may have a complementary role of spirometry in detecting subtle airways changes in general practice. However, systemic studies are required to investigate the clinical implication of each IOS index.
authors: Sapporo Cough Asthma and Allergy Center, Center, South−4 West−14 Chuo-ku, Sapporo, Hokkaido, Japan. tanaka@idaimaes4−naika.com
authors: Hiroshi
authors: H
authors: Tanaka
authors: Soichiro
authors: S
authors: Hozawa
authors: Junya
authors: J
authors: Kitada
authors: Masaru
authors: M
authors: Fujii
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D009330:Nebulizers and Vaporizers; D009991:Oscillometry / Q000379:methods*; D012129:Respiratory Function Tests / Q000379:methods; D057968:Transdermal Patch
chemical_list: D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D018927:Anti-Asthmatic Agents