title: Spirastrellolide B: construction of the C(26)-C(40) northern hemisphere and a related [5,5,7]-bis-spiroketal analogue.
abstract: Differential synthetic access to an advanced C26-C40 northern hemisphere fragment of spirastrellolide B and to a related [5,5,7]-bis-spiroketal analogue from a common intermediate has been achieved. Central to this venture is the regiocontrolled functionalization of a C(31-32) alkyne, exploiting different transition metal catalysts (cf. Pt(II) and Au(I)).
authors: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: Xiaozhao
authors: X
authors: Wang
authors: Thomas J
authors: TJ
authors: Paxton
authors: Ningkun
authors: N
authors: Li
authors: Amos B
authors: AB
authors: Smith
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; D013141:Spiro Compounds; C519027:spirastrellolide B