title: Alkalosis leads to the over-activity of cortical principal neurons.
abstract: Alkalosis patients manifest anxiety, manic and convulsion. The elevation of mood and behavior is hypothetically a scenario that alkalosis resets the functional status of neuronal networks to overexcitation. In addition to the downregulation of inhibitory neurons, we examined whether alkalosis upregulates the functions of cortical principal neurons by electrophysiological approach. High extracellular pH condition downgrades inhibitory postsynaptic current frequency, as well as upregulates excitatory synaptic events and spike production in cortical principal neurons. Their functional upregulation is associated with the decreases of spike refractory period and threshold potential. Alkalosis downregulates GABA release from inhibitory neurons and upregulates the functions of principal neurons, which lead to imbalance between inhibitory and excitatory networks for the elevated mood and behaviors.
authors: Department of Neurology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, PR China.
authors: Yunting
authors: Y
authors: Lu
authors: Lian
authors: L
authors: Yi
authors: Danian
authors: D
authors: Liu
authors: Jinlong
authors: J
authors: Li
authors: Ling
authors: L
authors: Sun
authors: Zhongling
authors: Z
authors: Zhang
mesh_terms: D000200:Action Potentials; D000471:Alkalosis / Q000503:physiopathology*; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials; D051379:Mice; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid