title: GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.
abstract: The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.
authors: Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America.
authors: Amelia Soto
authors: AS
authors: Hopkin
authors: William
authors: W
authors: Gordon
authors: Rachel Herndon
authors: RH
authors: Klein
authors: Francisco
authors: F
authors: Espitia
authors: Kenneth
authors: K
authors: Daily
authors: Michael
authors: M
authors: Zeller
authors: Pierre
authors: P
authors: Baldi
authors: Bogi
authors: B
authors: Andersen
mesh_terms: D002118:Calcium / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics*; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D063146:Polycomb-Group Proteins / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D034741:RNA, Small Interfering; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D011503:Transglutaminases / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C473143:GRHL3 protein, human; D047908:Intracellular Signaling Peptides and Proteins; C497422:KMT2A protein, human; C120898:KMT2D protein, human; D009363:Neoplasm Proteins; D063146:Polycomb-Group Proteins; D034741:RNA, Small Interfering; D014157:Transcription Factors; C502547:WDR5 protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; D011503:Transglutaminases; C105804:transglutaminase 1; D002118:Calcium