title: [Preparation of alpha-tricalcium phosphate/HA whisker/carboxymethyl chitosan-gelatin composite porous bone cement].
abstract: In order to investigate the effects of HA whisker and carboxymethyl chitosan-gelatin(CMC-Gel) on the mechanical properties of porous calcium phosphate cement, a series of alpha-tricalcium phosphate (alpha-TCP), HA whisker and L-sodium glutamate porogen with different mass fractions were mixed, and setting liquid was added to them to prepare alpha-TCP/HA whisker composite porous bone cement. Then, the cement was immersed in a series of CMC-Gel solutions which had different weight ratios of CMC to Gel to prepare alpha-TCP/HA whisker/CMC-Gel composite porous bone cement. The compressive strengths and microstructure of cement were characterized by mechanical testing machine and SEM. The results showed that when the mass fraction of HA whisker is 4%, the compressive strength of alpha-TCP/HA whisker composite porous bone cement reaches 2.57MPa, which is 1.81 times that of alpha-TCP bone cement. When the weight ratio of CMC to Gel is 50:50, the compressive strength of alpha-TCP/HA whisker/CMC-Gel composite porous bone cement is 3. 34MPa, which is 2.35 times that of alpha-TCP bone cement, and the toughness of the composite cement is greatly improved as well.
authors: College of Material Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Dongjuan
authors: D
authors: Wei
authors: Xiang
authors: X
authors: Zhang
authors: Jianwen
authors: J
authors: Gu
authors: Ping
authors: P
authors: Hu
authors: Weizhong
authors: W
authors: Yang
authors: Dongning
authors: D
authors: Chen
authors: Dali
authors: D
authors: Zhou
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D001843:Bone Cements / Q000138:chemical synthesis*; D002130:Calcium Phosphates / Q000737:chemistry*; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019245:Compressive Strength; D005780:Gelatin / Q000737:chemistry*; D006882:Hydroxyapatites / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485828:alpha-tricalcium phosphate; C514968:carboxymethyl-chitosan; C094280:hydroxyapatite-tricalciumphosphate composite; D005780:Gelatin; D048271:Chitosan