title: Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents.
abstract: Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 1 Meedan Elkhartoom, Alexandria 21521, Egypt.
authors: Ola H
authors: OH
authors: Rizk
authors: Omaima G
authors: OG
authors: Shaaban
authors: Ibrahim M
authors: IM
authors: El-Ashmawy
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005557:Formaldehyde / Q000009:adverse effects; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D011743:Pyrimidines / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014230:Triazoles / Q000737:chemistry; D014425:Turpentine / Q000009:adverse effects; D014456:Ulcer / Q000139:chemically induced
chemical_list: D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D014230:Triazoles; C476003:thienopyrimidine; D005557:Formaldehyde; D014425:Turpentine