title: Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is an important cause of cancer death with no clear prognostic biomarker. Expression of prion (PrP) has been reported to be a marker of poor prognosis in a series of Caucasian PDAC cases. We determined the prognostic value of PrP in a racially and geographically diverse population-based series of PDAC cases. PrP expression was examined in 142 PDAC cases from three cancer registries. Cases included 71 Caucasian, 54 Asian/Pacific Islanders and 17 Blacks diagnosed from 1983-2000, and followed through 2008. Hazard ratios (HR) and 95% confidence intervals (CIs) for the association of PrP expression with survival were computed after adjustment for case attributes. The risk of death was about four times higher (HR=3.8; 95% PDAC cases with PrP(+) tumors (median survival 5 months) compared to the 34 cases with PrP(-) tumors (median survival 20 months). Of 51 cases with resected, localized PDAC median survival was 74 months for 17 cases with PrP(-) tumors versus 14 months for 34 cases with PrP(+) tumors (HR=6.7; 95% CI: 2.6, 17.4). All 6 surviving cases had PrP(-) negative tumors (median survival, > 10 years). PrP may have potential as a prognostic biomarker in PDAC patient management.
authors: Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
authors: Man-Sun
authors: MS
authors: Sy
authors: Sean F
authors: SF
authors: Altekruse
authors: Chaoyang
authors: C
authors: Li
authors: Charles F
authors: CF
authors: Lynch
authors: Marc T
authors: MT
authors: Goodman
authors: Brenda Y
authors: BY
authors: Hernandez
authors: Lan
authors: L
authors: Zhou
authors: Maria Sibug
authors: MS
authors: Saber
authors: Stephen M
authors: SM
authors: Hewitt
authors: Wei
authors: W
authors: Xin
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011328:Prions / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D018426:SEER Program; D046888:Tissue Array Analysis; D014015:Tissue Banks
chemical_list: D014408:Biomarkers, Tumor; D011328:Prions