title: Pharmacology of somatrotropin pegylated by electron-beam synthesis nanotechnology.
abstract: Pharmacological characteristics of somatotropin pegylated using electron-beam synthesis nanotechnology (PEG-STH) were studied. Oral PEG-STH stimulated the intensity of protein and lipid metabolism and endochondral bone growth without modifying the processes of periosteal and endosteal bone formation. Specific activity of this substance administered orally significantly surpassed that of parenteral non-modified growth hormone.
authors: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
authors: A M
authors: AM
authors: Dygai
authors: G N
authors: GN
authors: Zyuz'kov
authors: A A
authors: AA
authors: Churin
authors: V V
authors: VV
authors: Zhdanov
authors: A V
authors: AV
authors: Artamonov
authors: A A
authors: AA
authors: Bekarev
authors: P G
authors: PG
authors: Madonov
authors: D N
authors: DN
authors: Kinsht
authors: T I
authors: TI
authors: Fomina
authors: T V
authors: TV
authors: Vetoshkina
authors: T Yu
authors: TY
authors: Dubskaia
authors: L A
authors: LA
authors: Ermolaeva
authors: E V
authors: EV
authors: Udut
authors: L A
authors: LA
authors: Miroshnichenko
authors: E V
authors: EV
authors: Simanina
authors: L A
authors: LA
authors: Stavrova
authors: A V
authors: AV
authors: Chaikovskiy
authors: T S
authors: TS
authors: Markova
authors: M Yu
authors: MY
authors: Minakova
authors: D V
authors: DV
authors: Reihart
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D019382:Human Growth Hormone / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D036103:Nanotechnology; D011092:Polyethylene Glycols; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011506:Proteins; D019382:Human Growth Hormone; D011092:Polyethylene Glycols