title: Drug-resistant tuberculosis transmission and resistance amplification within families.
abstract: Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplified within families.
authors: London School of Hygiene and Tropical Medicine, London, UK. jseddon@sun.ac.za
authors: James A
authors: JA
authors: Seddon
authors: Rob M
authors: RM
authors: Warren
authors: Donald A
authors: DA
authors: Enarson
authors: Nulda
authors: N
authors: Beyers
authors: H Simon
authors: HS
authors: Schaaf
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013019:South Africa / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*
chemical_list: D000995:Antitubercular Agents