title: A novel blood-based biomarker for detection of autism spectrum disorders.
abstract: Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used for protein profiling of blood plasma of children with such disorders in order to identify proteins/peptides that may be used as biomarkers for detection of the disorders. Three differentially expressed peptides with mass-charge (m/z) values of 2020 ± 1, 1864 ± 1 and 1978 ± 1 Da in the heparin plasma of children with ASD that were significantly changed as compared with the peptide pattern of the non-ASD control group are reported here. This novel set of biomarkers allows for a reliable blood-based diagnostic tool that may be used in diagnosis and potentially, in prognosis of ASD.
authors: School of Natural Sciences, Linnaeus University, Kalmar, Sweden.
authors: N
authors: N
authors: Momeni
authors: J
authors: J
authors: Bergquist
authors: L
authors: L
authors: Brudin
authors: F
authors: F
authors: Behnia
authors: B
authors: B
authors: Sivberg
authors: M T
authors: MT
authors: Joghataei
authors: B L
authors: BL
authors: Persson
mesh_terms: D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000097:blood; D001321:Autistic Disorder / Q000097:blood* / Q000175:diagnosis* / Q000523:psychology; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D008297:Male; D013058:Mass Spectrometry; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D040081:Protein Array Analysis; D040901:Proteomics; D012016:Reference Values; D020539:Sequence Analysis, Protein
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D008243:1-Acylglycerophosphocholine O-Acyltransferase; C543069:LPCAT3 protein, human