title: Successful salvage using combined radiation and ABMT for patients with recurrent CNS NGGCT following failed initial transplant.
abstract: Intracranial germ cell tumours (GCTs) are a rare and diverse group of tumours. Histology determines the type of treatment, natural history and prognosis. Germinoma GCTs account for the majority and are very radiosensitive. Conversely, non-germinoma GCTs (NGGCTs) are heterogeneous, relatively radioresistant and have a high risk of relapse despite multimodality therapy. Treatment of recurrence in these patients remains a therapeutic challenge. In this report we review the current literature for treatment of recurrent NGGCTs and present a case of recurrent NGGCT who relapsed despite autologous stem cell transplant (ASCT). The patient was successfully cured using multimodality therapy, consisting of repeat ASCT, intensity modulated radiation therapy and stereotactic radiosurgery.
authors: Division of Radiation Oncology, The Ottawa Hospital, Ottawa, Canada.
authors: Kyle
authors: K
authors: Malone
authors: Jennifer
authors: J
authors: Croke
authors: Colin
authors: C
authors: Malone
authors: Shawn
authors: S
authors: Malone
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D018447:Medical Futility; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000628:therapy*; D016879:Salvage Therapy / Q000379:methods*