title: New antifungal pyranoisoflavone from Ficus tikoua Bur.
abstract: Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2″,2″-dimethylpyrano (5″,6″:7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and lupiwighteone (3) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR ((1)H-(1)H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MS(n) analyses. The antifungal activities of 1-3 against Phytophthora infestans were evaluated by direct spore germination assay, and the IC(50) values were 262.442, 198.153 and 90.365 μg·mL(-1), respectively.
authors: College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors: Shaopeng
authors: S
authors: Wei
authors: College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors: Wenjun
authors: W
authors: Wu
authors: College of Plant Protection and Institute of Pesticide Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors: Zhiqin
authors: Z
authors: Ji
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D030681:Ficus / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055750:Phytophthora infestans / Q000502:physiology*; D013172:Spores, Fungal / Q000254:growth & development*
chemical_list: D000935:Antifungal Agents; D007529:Isoflavones