title: Guards of the great wall: bacterial lysozyme inhibitors.
abstract: Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if not all, animals produce lysozymes as key effectors of their innate immune system. Recently, highly specific bacterial proteinaceous lysozyme inhibitors against the three major animal lysozyme families have been discovered in bacteria, and these may represent a bacterial answer to animal lysozymes. Here, we will review their properties and phylogenetic distribution, present their structure and molecular interaction mechanism with lysozyme, and discuss their possible biological functions and potential applications.
authors: Laboratory of Food Microbiology, Leuven Food Science and Nutrition Research Centre, KU Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium.
authors: Lien
authors: L
authors: Callewaert
authors: Joris M
authors: JM
authors: Van Herreweghe
authors: Lise
authors: L
authors: Vanderkelen
authors: Seppe
authors: S
authors: Leysen
authors: Arnout
authors: A
authors: Voet
authors: Chris W
authors: CW
authors: Michiels
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D009113:Muramidase / Q000037:antagonists & inhibitors*; D010802:Phylogeny; D017385:Sequence Homology
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D009113:Muramidase