title: Investigation of myoepithelial cell differentiation into Schwann-like             cells in salivary adenoid cystic carcinoma associated with perineural invasion.
abstract: Perineural invasion (PNI) is common in salivary adenoid cystic carcinoma             (SACC). The aim of the present study was to explore the association of the Schwann-like             cell differentiation with PNI in SACC. Twenty-eight cases of SACC and 10 cases             of acinic cell carcinoma (ACA) were examined for the expression of the Schwann             cell markers Leu-7 by immunohistochemical staining. The correlation between Leu-7             expression and PNI was analyzed using κ analysis. Immunofluorescence double-staining             and pre-embedding immunogold-silver cytochemistry were used to detect the co-expression             and the location of Leu-7 and the myoepithelial cell marker α-smooth muscle actin             (α-SMA). PNI was identified in 16 SACCs (57.1%) and 1 ACA (10%) and the overexpression             of Leu-7 was detected in 22 SACCs (78.6%) and in none of the ACAs (0%). The differences             between PNI and Leu-7 expression in SACC and ACA were significant (P<0.05).             A correlation was identified between the expression of Leu-7 and PNI in SACC (κ=0.533,             P=0.01). In SACC, Leu-7 and α-SMA were co-expressed in the cytoplasm in the same             myoepithelial cells. We suggest that Schwann‑like cell differentiation correlates             with PNI in SACC and that the differentiation of myoepithelial into Schwann‑like             cells may be one of the mechanisms through which PNI occurs in SACC.
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi'an, Shannxi, PR China.
authors: Wei
authors: W
authors: Chen
authors: Shaozhong
authors: S
authors: Dong
authors: Jun
authors: J
authors: Zhou
authors: Moyi
authors: M
authors: Sun
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D000368:Aged; D018959:CD57 Antigens / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000378:metabolism / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010502:Perineum / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012583:Schwann Cells / Q000166:cytology*
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D018959:CD57 Antigens