title: The neuroimmune connection interferes with tissue regeneration and chronic inflammatory disease in the skin.
abstract: Research over the past decades has revealed close interactions between the nervous and immune systems that regulate peripheral inflammation and link psychosocial stress with chronic somatic disease. Besides activation of the sympathetic and the hypothalamus-pituitary-adrenal axis, stress leads to increased neurotrophin and neuropeptide production in organs at the self-environment interface. The scope of this short review is to discuss key functions of these stress mediators in the skin, an exemplary stress-targeted and stress-sensitive organ. We will focus on the skin's response to acute and chronic stress in tissue regeneration and pathogenesis of allergic inflammation, psoriasis, and skin cancer to illustrate the impact of local stress-induced neuroimmune interaction on chronic inflammation.
authors: Center for Internal Medicine and Dermatology, Charité-University Medicine, Berlin, Germany. eva.peters@eva-peters.com
authors: Eva M J
authors: EM
authors: Peters
authors: Christiane
authors: C
authors: Liezmann
authors: Burghard F
authors: BF
authors: Klapp
authors: Johannes
authors: J
authors: Kruse
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000276:immunology* / Q000503:physiopathology*; D003876:Dermatitis, Atopic / Q000276:immunology / Q000503:physiopathology; D006197:Hair / Q000254:growth & development; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology / Q000503:physiopathology; D007111:Immunity, Cellular; D018448:Models, Immunological; D008959:Models, Neurological; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology; D015213:Neuroimmunomodulation; D009479:Neuropeptides / Q000276:immunology / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000503:physiopathology; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology; D012038:Regeneration / Q000276:immunology* / Q000502:physiology*; D012878:Skin Neoplasms / Q000276:immunology / Q000503:physiopathology; D013312:Stress, Physiological
chemical_list: D009414:Nerve Growth Factors; D009479:Neuropeptides