title: Prognostication and prediction using gene expression profiling in oesophageal cancer.
abstract: OBJECTIVE
  To evaluate current literature on gene expression profiling in oesophageal cancer.
  
  
  METHODS
  We performed a review of the literature (2000-2010) on prognostication and prediction using gene expression analysis in oesophageal cancer.
  
  
  RESULTS
  Seventeen papers comprising 638 patients were included. Gene expression profiles studied in relation to survival, lymph node metastasis and response to neoadjuvant therapy. Most studies included a limited number of patients. Several prognostic and predictive gene signatures were identified with different accuracies. In only one study, the gene signature was validated in a large, independent patient cohort.
  
  
  CONCLUSIONS
  Gene expression profiling has potential clinical applications in oesophageal cancer. Especially a signature which is predictive for response to neoadjuvant treatment could be of great clinical value. To date, most published studies suffer from an underpowered training cohort or lack adequate validation. Clinicians should put effort in the collection of high quality tissue samples and should participate in biobank initiatives, considering the increasing availability and possibilities of sequencing technology.
authors: Department of Surgery, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.stiekema@nki.nl
authors: J
authors: J
authors: Stiekema
authors: H
authors: H
authors: Boot
authors: B M P
authors: BM
authors: Aleman
authors: L F A
authors: LF
authors: Wessels
authors: J W
authors: JW
authors: van Sandick
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000628:therapy; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016629:Esophagectomy; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D046228:Microarray Analysis; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome