title: Dialysis nanoprecipitation of polystyrene nanoparticles.
abstract: Using a facile dialysis nanoprecipitation method, nanoparticles of several hundred nanometers have been successfully generated from a "traditional," non-biodegradable polymer, that is, polystyrene. The effect of initial polymer concentration inside the dialysis membrane, as well as the polymer/solvent system and the ionic strength (electrolyte concentration) of the dialysis solution, on nanoparticle size is examined. A nucleation-aggregation mechanism has been provided to explain the observed trends. Furthermore, we determine the zeta potential as a function of ionic strength for the generated nanoparticles and show that anionic charging may be present in the system.
authors: Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
authors: Chuan
authors: C
authors: Zhang
authors: Jae Woo
authors: JW
authors: Chung
authors: Rodney D
authors: RD
authors: Priestley
mesh_terms: D000838:Anions / Q000737:chemistry; D003956:Dialysis; D053758:Nanoparticles / Q000737:chemistry*; D009994:Osmolar Concentration; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*
chemical_list: D000838:Anions; D011137:Polystyrenes