title: Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations.
abstract: Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, the solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will influence the final physical structure of the obtained solid dispersion particles. This review presents an overview of the interplay between manufacturing process, formulation parameters, physical structure, and performance of the solid dispersions with respect to stability and drug release characteristics.
authors: Laboratory of Pharmacotechnology and Biopharmacy, KU Leuven, Leuven, Belgium.
authors: Amrit
authors: A
authors: Paudel
authors: Zelalem Ayenew
authors: ZA
authors: Worku
authors: Joke
authors: J
authors: Meeus
authors: Sandra
authors: S
authors: Guns
authors: Guy
authors: G
authors: Van den Mooter
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D003890:Desiccation / Q000379:methods; D004339:Drug Compounding / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D014867:Water