title: The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis.
abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), which claims approximately two million people annually, remains a global health concern. The non-replicating or dormancy like state of this pathogen which is impervious to anti-tuberculosis drugs is widely recognized as the culprit for this scenario. The dormancy survival regulator (DosR) regulon, composed of 48 co-regulated genes, is held as essential for Mtb persistence. The DosR regulon is regulated by a two-component regulatory system consisting of two sensor kinases-DosS (Rv3132c) and DosT (Rv2027c), and a response regulator DosR (Rv3133c). The underlying regulatory mechanism of DosR regulon expression is very complex. Many factors are involved, particularly the oxygen tension. The DosR regulon enables the pathogen to persist during lengthy hypoxia. Comparative genomic analysis demonstrated that the DosR regulon is widely distributed among the mycobacterial genomes, ranging from the pathogenic strains to the environmental strains. In-depth studies on the DosR response should provide insights into its role in TB latency in vivo and shape new measures to combat this exceeding recalcitrant pathogen.
authors: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China.
authors: Tian
authors: T
authors: Chen
authors: Liming
authors: L
authors: He
authors: Wanyan
authors: W
authors: Deng
authors: Jianping
authors: J
authors: Xie
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D004268:DNA-Binding Proteins; D015964:Gene Expression Regulation, Bacterial; D014644:Genetic Variation; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D055985:Latent Tuberculosis / Q000382:microbiology; D009161:Mycobacterium / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000472:pathogenicity; D010100:Oxygen / Q000378:metabolism; D006656:Protamine Kinase / Q000235:genetics; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics*; D018085:Regulon; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C542863:DosR protein, Mycobacterium tuberculosis; D011494:Protein Kinases; C506260:DevS protein, Mycobacterium tuberculosis; D006656:Protamine Kinase; C542862:DosT protein, Mycobacterium tuberculosis; D010100:Oxygen