title: Briacavatolides A-C, new briaranes from the Taiwanese octocoral Briareum excavatum.
abstract: In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareumexcavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A-C (1-3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cancer cell lines were evaluated.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Tsun-Tai
authors: TT
authors: Yeh
authors: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Shang-Kwei
authors: SK
authors: Wang
authors: Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan.
authors: Chang-Feng
authors: CF
authors: Dai
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chang-Yih
authors: CY
authors: Duh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003587:Cytomegalovirus / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013624:Taiwan
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D004224:Diterpenes; C530545:briaexcavatin