title: Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements.
abstract: Two new phosphodiesterase-5 inhibitors (PDE-5) which consist of one sildenafil analogue and one thiosildenafil analogue have been found in heath supplements. The structural properties of these analogues have been elucidated by NMR, high resolution MS, MS(2), UV and IR spectroscopy. The sildenafil analogue is very similar to aildenafil and the thiosildenafil analogue is similar to thioaildenafil, except the ethoxy group bonded to phenyl ring is replaced by a propoxy group. Hence, the sildenafil analogue is named as propoxyphenyl aildenafil or propoxyphenyl methisosildenafil and the thiosildenafil analogue as propoxyphenyl thioaildenafil or propoxyphenyl thiomethisosildenafil.
authors: Pharmaceutical Laboratory, Applied Sciences Group, Health Sciences Authority, 11 Outram Road, Singapore 169078, Singapore. keecheeleong@gmail.com
authors: Chee-Leong
authors: CL
authors: Kee
authors: Xiaowei
authors: X
authors: Ge
authors: Hwee-Ling
authors: HL
authors: Koh
authors: Min-Yong
authors: MY
authors: Low
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019587:Dietary Supplements / Q000032:analysis*; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D058986:Phosphodiesterase 5 Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification*; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification; D011743:Pyrimidines / Q000737:chemistry / Q000302:isolation & purification*; D000068677:Sildenafil Citrate; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013450:Sulfones / Q000737:chemistry / Q000302:isolation & purification*; D053719:Tandem Mass Spectrometry
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D011743:Pyrimidines; D013450:Sulfones; C520604:aildenafil; D000068677:Sildenafil Citrate; C539492:thiosildenafil