title: Riluzole-induced lung injury in two patients with amyotrophic lateral sclerosis.
abstract: Riluzole has recently been proven as the first effective drug for the treatment of amyotrophic lateral sclerosis (ALS). We report two rare cases of lung injury caused by riluzole therapy in patients with ALS. Chest radiographs showed bilateral lower lobe, dorsal-dominant ground glass opacity, and/or consolidation. A drug lymphocyte stimulation test (DLST) of peripheral blood or bronchoalveolar lavage cells was positive for riluzole. Histopathological examination of lung biopsy specimens revealed lung injury without fungoid granuloma, vasculitis, or diffuse alveolar damage. To the best of our knowledge, this is the first report of riluzole-induced lung injury with positive DLST results.
authors: Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan.
authors: Takuya
authors: T
authors: Kakuta
authors: Hirokuni
authors: H
authors: Hirata
authors: Sayo
authors: S
authors: Soda
authors: Taichi
authors: T
authors: Shiobara
authors: Mineaki
authors: M
authors: Watanabe
authors: Masamitsu
authors: M
authors: Tatewaki
authors: Fumiya
authors: F
authors: Fukushima
authors: Kazuyuki
authors: K
authors: Chibana
authors: Kumiya
authors: K
authors: Sugiyama
authors: Masafumi
authors: M
authors: Arima
authors: Honma
authors: H
authors: Koichi
authors: Takeshi
authors: T
authors: Fukuda
authors: Yasutsugu
authors: Y
authors: Fukushima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000009:adverse effects; D011239:Prednisolone / Q000627:therapeutic use; D019782:Riluzole / Q000009:adverse effects*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D019782:Riluzole; D011239:Prednisolone