title: Regulation of cholesterol biosynthesis and cancer signaling.
abstract: Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.
authors: Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors: Andrey
authors: A
authors: Gorin
authors: Linara
authors: L
authors: Gabitova
authors: Igor
authors: I
authors: Astsaturov
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D015398:Signal Transduction; D013261:Sterols / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D013261:Sterols; D002784:Cholesterol