title: Evaluation of the cytotoxic activity of some Brazilian medicinal plants.
abstract: Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, β-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs.
authors: Department of Chemistry, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.
authors: Sandra S
authors: SS
authors: Ribeiro
authors: Aline M
authors: AM
authors: de Jesus
authors: Charlene S
authors: CS
authors: dos Anjos
authors: Thanany B
authors: TB
authors: da Silva
authors: Alan D C
authors: AD
authors: Santos
authors: Jemmyson R
authors: JR
authors: de Jesus
authors: Moacir S
authors: MS
authors: Andrade
authors: Tais S
authors: TS
authors: Sampaio
authors: Wesley F
authors: WF
authors: Gomes
authors: Péricles B
authors: PB
authors: Alves
authors: Adriana A
authors: AA
authors: Carvalho
authors: Claudia
authors: C
authors: Pessoa
authors: Manoel O
authors: MO
authors: de Moraes
authors: Maria L B
authors: ML
authors: Pinheiro
authors: Ana Paula N
authors: AP
authors: Prata
authors: Arie F
authors: AF
authors: Blank
authors: Renata
authors: R
authors: Silva-Mann
authors: Valeria R S
authors: VR
authors: Moraes
authors: Emmanoel V
authors: EV
authors: Costa
authors: Paulo Cesar L
authors: PC
authors: Nogueira
authors: Daniel P
authors: DP
authors: Bezerra
mesh_terms: D029061:Annonaceae / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic; D029062:Apocynaceae / Q000737:chemistry; D000081008:Bicyclic Monoterpenes; D001938:Brazil; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D028084:Clusiaceae / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D031331:Hyptis / Q000737:chemistry; D031286:Jatropha / Q000737:chemistry; D007840:Latex / Q000737:chemistry; D032411:Lippia / Q000737:chemistry; D019684:Magnoliopsida / Q000737:chemistry*; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D003374:Coumarins; D007840:Latex; D039821:Monoterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; C010789:beta-pinene; C030123:coumarin