title: Development of low-calorie guava preserves with prebiotics and evaluation of their effects on carcinogenesis biomarkers in rats.
abstract: Faced with the search for healthy products that provide additional benefits to consumers' health, the main objectives of this work were to develop a low-calorie preserve containing prebiotics (lactulose and polydextrose) and to evaluate the effects of these prebiotics on oxidative stress and colon carcinogenesis in male rats treated with 1,2-dimethylhydrazine (DMH). A total of 62.5% w/w of the sucrose in conventional preserves was replaced by polydextrose, and lactulose was added at 0%, 16%, 19.5% or 23% w/w concentrations. The acceptance of these four low-calorie guava preserve samples and the conventional sample was equal (P>0.05), with a score of 6.49. The level of degradation of lactulose was low (18.45 g100 g(-1)lactulose), ensuring that even at a lower concentration of this prebiotic (16% w/w), the concentration remained above the minimum level considered functional. We found that consumption of the low-calorie preserves with prebiotics does not have an effect on the development of mucin-negative ACF and classical ACF in the initiation phase of the mutagenic process. However, the consumption of 1.5 g of the preserve/rat/day potentiated lipid peroxidation and proteic oxidation in the liver.
authors: UFLA Federal University of Lavras, Department of Food Science, 37200-000, Lavras, MG, Brazil. camilacarvalhomenezes@posgrad.ufla.br
authors: Camila Carvalho
authors: CC
authors: Menezes
authors: João
authors: J
authors: de Deus Souza Carneiro
authors: Soraia Vilela
authors: SV
authors: Borges
authors: Vera Sônia Nunes
authors: VS
authors: da Silva
authors: Maísa Ribeiro Pereira Lima
authors: MR
authors: Brigagão
authors: Luciana
authors: L
authors: Azevedo
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor / Q000378:metabolism; D005504:Food Analysis; D005519:Food Preservation; D008297:Male; D056692:Prebiotics; D031647:Psidium / Q000737:chemistry*; D051381:Rats
chemical_list: D016588:Anticarcinogenic Agents; D014408:Biomarkers, Tumor; D056692:Prebiotics