title: Lung function and breathing pattern in subjects developing high altitude pulmonary edema.
abstract: BACKGROUND
  The purpose of the study was to comprehensively evaluate physiologic changes associated with development of high altitude pulmonary edema (HAPE). We tested whether changes in pulmonary function and breathing pattern would herald clinically overt HAPE at an early stage.
  
  
  METHODS
  In 18 mountaineers, spirometry, diffusing capacity, nitrogen washout, nocturnal ventilation and pulse oximetry were recorded at 490 m and during 3 days after rapid ascent to 4559 m. Findings were compared among subjects developing HAPE and those remaining well (controls).
  
  
  RESULTS
  In 8 subjects subsequently developing radiographically documented HAPE at 4559 m, median FVC declined to 82% of low altitude baseline while closing volume increased to 164% of baseline (P<0.05, both instances). In 10 controls, FVC decreased slightly (to 93% baseline, P<0.05) but significantly less than in subjects with HAPE and closing volume remained unchanged. Sniff nasal pressure was reduced in both subjects with and without subsequent HAPE. During nights at 4559 m, mean nocturnal oxygen saturation dropped to lower values while minute ventilation, the number of periodic breathing cycles and heart rate were higher (60%; 8.6 L/min; 97 cycles/h; 94 beats/min, respectively) in subjects subsequently developing HAPE than in controls (73%; 5.1 L/min; 48 cycles/h; 79 beats/min; P<0.05 vs. HAPE, all instances).
  
  
  CONCLUSIONS
  The results comprehensively represent the pattern of physiologic alterations that precede overt HAPE. The changes in lung function are consistent with reduced lung compliance and impaired gas exchange. Pronounced nocturnal hypoxemia, ventilatory control instability and sympathetic stimulation are further signs of subsequent overt HAPE.
authors: Pulmonary Division, University Hospital Zurich, Zurich, Switzerland.
authors: Christian F
authors: CF
authors: Clarenbach
authors: Oliver
authors: O
authors: Senn
authors: Andreas L
authors: AL
authors: Christ
authors: Manuel
authors: M
authors: Fischler
authors: Marco
authors: M
authors: Maggiorini
authors: Konrad E
authors: KE
authors: Bloch
mesh_terms: D000328:Adult; D000532:Altitude Sickness / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008168:Lung / Q000502:physiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012119:Respiration; D013147:Spirometry; D014797:Vital Capacity