title: [Magnesium disorder in metabolic bone diseases].
abstract: Magnesium is abundantly distributed among the body. The half of the magnesium exists in the bone. In addition, magnesium is the second most abundant intracellular cation in vertebrates and essential for maintaining physiological function of the cells. Epidemiologic studies have demonstrated that magnesium deficiency is a risk factor for osteoporosis. The mechanism of bone fragility caused by magnesium deficiency has been intensely studied using animal models of magnesium deficiency. Magnesium deficiency causes decreased osteoblastic function and increased number of osteoclasts. Magnesium deficiency also accelerates mineralization in bone. These observations suggest that disturbed bone metabolic turnover and mineralization causes bone fragility.
authors: Department of Metabolism, Osaka City University Graduate School of Medicine, Japan.
authors: Akira
authors: A
authors: Ishii
authors: Yasuo
authors: Y
authors: Imanishi
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism*; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000150:complications*; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts; D010024:Osteoporosis / Q000209:etiology; D051381:Rats; D012307:Risk Factors
chemical_list: D008274:Magnesium