title: Extended-spectrum beta-lactamase-producing bacteria in a tertiary care hospital in Madrid: epidemiology, risk factors and antimicrobial susceptibility patterns.
abstract: BACKGROUND
  Extended-spectrum beta-lactamase (ESBL) producing bacteria have been increasingly reported as causal agents of nosocomial infection worldwide. Resistance patterns vary internationally, and even locally, from one institution to the other. We investigated the clinical isolates positive for ESBL-producing bacteria in our institution, a tertiary care hospital in Madrid (Spain), during a 2-year period (2007-2008).
  
  
  METHODS
  Clinical and microbiological data were retrospectively reviewed. Two hundred and nineteen patients were included in the study.
  
  
  RESULTS
  Advanced age, diabetes, use of catheters, previous hospitalization and previous antibiotic treatment were some of the risk factors found among patients. Escherichia coli was the most frequent isolate, and urinary tract the most common site of isolation. Internal Medicine, Intensive Care Unit (ICU) and General Surgery presented the highest number of isolates. There were no outbreaks during the study period. Antibiotic patterns showed high resistance rates to quinolones in all isolates. There was 100% sensitivity to carbapenems.
  
  
  CONCLUSIONS
  Carbapenems continue to be the treatment of choice for ESBL-producing bacteria. Infection control measures are of great importance to avoid the spread of these nosocomial infections.
authors: Department of General Surgery, 'La Princesa' University Hospital, Madrid, Spain.
authors: Ines
authors: I
authors: Rubio-Perez
authors: Elena
authors: E
authors: Martin-Perez
authors: Diego Domingo
authors: DD
authors: Garcia
authors: Manuel Lopez-Brea
authors: ML
authors: Calvo
authors: Eduardo Larrañaga
authors: EL
authors: Barrera