title: Late-onset scleroderma renal crisis induced by tacrolimus and prednisolone: a case report.
abstract: Scleroderma renal crisis (SRC) is a rare complication of systemic sclerosis (SSc) but can be severe enough to require temporary or permanent renal replacement therapy. Moderate to high dose corticosteroid use is recognized as a major risk factor for SRC. Furthermore, there have been reports of thrombotic microangiopathy precipitated by cyclosporine in patients with SSc. In this article, we report a patient with SRC induced by tacrolimus and corticosteroids. The aim of this work is to call attention to the risk of tacrolimus use in patients with SSc.
authors: 1Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, Tokyo, Japan; 2Department of Nephrology, Tokyo Kyosai Hospital, Meguro-ku, Tokyo, Japan; 3Hiramatsu Naika Clinic, Kokubunji, Tokyo, Japan; and 4Department of Nephrology, Tokyo Metropolitan Tama Medical Center, Fuchu-shi, Tokyo, Japan.
authors: Takahiro
authors: T
authors: Nunokawa
authors: Masanobu
authors: M
authors: Akazawa
authors: Naoto
authors: N
authors: Yokogawa
authors: Kota
authors: K
authors: Shimada
authors: Kazuko
authors: K
authors: Hiramatsu
authors: Yasuhide
authors: Y
authors: Nishio
authors: Shoji
authors: S
authors: Sugii
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000150:complications*; D016559:Tacrolimus / Q000009:adverse effects*; D057049:Thrombotic Microangiopathies / Q000139:chemically induced
chemical_list: D011239:Prednisolone; D016559:Tacrolimus