title: Definitive radiation therapy for extramammary Paget's disease.
abstract: BACKGROUND
  Extramammary Paget's disease (EMPD) is frequently inoperable because of old age and/or coexisting disease. We therefore reviewed the efficacy and toxicity of radiation therapy for EMPD.
  
  
  METHODS
  Fourteen patients with EMPD underwent definitive radiation therapy. Three patients had regional lymph node metastases before radiation therapy, but none had distant metastasis. Total doses of 52-80.2 Gy (median=60.6 Gy) were delivered to tumor sites in 26-43 fractions (median=33 fractions).
  
  
  RESULTS
  Four patients had developed recurrence at a median follow-up period of 47 months. The 5-year local control and disease-free rates were 71% and 63%, respectively. Two patients died of old age and renal failure at 6 and 51 months, respectively, after irradiation. The 5-year disease-free, cause-specific and overall survival rates were 46%, 100% and 79%, respectively. No therapy-related toxicities of grade 3 or greater were observed.
  
  
  CONCLUSIONS
  Radiation therapy is effective and safe, and appears to offer a curative treatment option for patients with EMPD.
authors: Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 236-0004 Japan. mhata@syd.odn.ne.jp
authors: Masaharu
authors: M
authors: Hata
authors: Izumi
authors: I
authors: Koike
authors: Hidefumi
authors: H
authors: Wada
authors: Etsuko
authors: E
authors: Miyagi
authors: Kazumasa
authors: K
authors: Odagiri
authors: Yumiko
authors: Y
authors: Minagawa
authors: Takeo
authors: T
authors: Kasuya
authors: Hisashi
authors: H
authors: Kaizu
authors: Tomio
authors: T
authors: Inoue
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000532:radiotherapy*