title: [Evolution of the frequency of congenital defects in newborn infants and fetuses from terminations of pregnancy after prenatal diagnosis in the period 1982-2009].
abstract: OBJECTIVE
  The study of congenital defects (CD) must include termination of pregnancy (TOP) for CD and evaluate risk factors that modify their frequency.
  
  
  METHODS
  Consecutive series of 517 newborn and 202 TOP with CD among 38,191 childbirths, between 1982-2009 years.
  
  
  RESULTS
  The mean frequency for newborns with CD is 13.54‰ and for newborn and TOP with CD is 18.73‰. Single CD are 61.12% in newborns and 52.17% in TOP. The 18.37% of CD in newborn and 40.58% of TOP are syndromic. Mean gestational age for TOP is 17.92 weeks. Overall frequency of anencephaly is 2.62‰ for newborns and 6.77 for 10,000 for newborns and TOP. Spina bifida is 3.14 for 10,000 newborns and 5.99 for 10,000 newborns and TOP. Overall frequency of Down syndrome (DS) is 10.74 for 10,000 newborns and 22.14 for 10,000 newborns and TOP. The percentage of foreign mothers was 35.9% in 2009 and the mean maternal age significantly increased in this period.
  
  
  CONCLUSIONS
  We observe a significant decrease of CD in newborns but not in their conception. We have not detected primary prevention for neural tube defects. The decrease in DS in newborns is not statistically relevant but ethnic diversity and maternal aging may be modifying the frequency. The 53% of CD were TOP in the period 2007-2009. It is mandatory a complete study for CD in TOP in order to offer serious reproductive counselling.
authors: Servicio de Pediatría, Hospital Universitario Dr. Peset, Valencia, España. sanchis_amp@gva.es
authors: Amparo
authors: A
authors: Sanchis Calvo
authors: Esther
authors: E
authors: Roselló-Sastre
authors: Beatriz
authors: B
authors: Marcos Puig
authors: Reyes
authors: R
authors: Balanzá Chancosa
authors: María Luisa
authors: ML
authors: Pérez Ebri
authors: Inmaculada
authors: I
authors: Alcover Barrachina
authors: Natalia
authors: N
authors: Camarasa Lillo
authors: Eva
authors: E
authors: Bermejo-Sánchez
authors: Jorge
authors: J
authors: Escandón Alvarez
mesh_terms: D000025:Abortion, Eugenic / Q000706:statistics & numerical data*; D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000757:Anencephaly / Q000453:epidemiology / Q000517:prevention & control; D001723:Birth Rate; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000517:prevention & control; D004314:Down Syndrome / Q000453:epidemiology / Q000517:prevention & control; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009017:Morbidity / Q000639:trends; D009436:Neural Tube Defects / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000639:trends; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology