title: Serotonin-1A receptor binding is positively associated with gray matter volume -- a multimodal neuroimaging study combining PET and structural MRI.
abstract: Animal models revealed that the serotonin-1A (5-HT(1A)) receptor modulates gray matter structure. However, there is a lack of evidence showing the relationship between 5-HT(1A) receptor concentration and gray matter in the human brain in vivo. Here, to demonstrate an association between the 5-HT(1A) receptor binding potential, an index for receptor concentration, and the local gray matter volume (GMV), an index for gray matter structure, we measured 35 healthy subjects with both positron emission tomography (PET) and structural magnetic resonance imaging (MRI). We found that regional heteroreceptor binding was positively associated with GMV in distinctive brain regions such as the hippocampi and the temporal cortices in both hemispheres (R(2) values ranged from 0.308 to 0.503, p<0.05 cluster-level FDR-corrected). Furthermore, autoreceptor binding in the midbrain raphe region was positively associated with GMV in forebrain projection sites (R(2)=0.656, p=0.001). We also observed a broad range between 5-HT(1A) receptor binding and GMV. Given the congruence of altered 5-HT(1A) receptor concentrations and GMV reduction in depression or Alzheimer's disease as reported by numerous studies, these results might provide new insights towards understanding the mechanisms behind GMV alterations observed in these brain disorders.
authors: Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria.
authors: Christoph
authors: C
authors: Kraus
authors: Andreas
authors: A
authors: Hahn
authors: Markus
authors: M
authors: Savli
authors: Georg S
authors: GS
authors: Kranz
authors: Pia
authors: P
authors: Baldinger
authors: Anna
authors: A
authors: Höflich
authors: Christoph
authors: C
authors: Spindelegger
authors: Johanna
authors: J
authors: Ungersboeck
authors: Daniela
authors: D
authors: Haeusler
authors: Markus
authors: M
authors: Mitterhauser
authors: Christian
authors: C
authors: Windischberger
authors: Wolfgang
authors: W
authors: Wadsak
authors: Siegfried
authors: S
authors: Kasper
authors: Rupert
authors: R
authors: Lanzenberger
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D055815:Young Adult
chemical_list: D044282:Receptor, Serotonin, 5-HT1A