title: Effects of intermittent 5-fluorouracil and low-dose cisplatin therapy on advanced and recurrent gastric cancer.
abstract: BACKGROUND
  Although combination therapy consisting of 5-fluorouracil (5-FU) and cisplatin for the treatment of gastric cancer has been reported, no consistent regimen has been established. Our aim was to determine the optimal treatment schedule of this therapy, for patients with advanced or recurrent gastric cancer.
  
  
  METHODS
  We conducted a phase II study to evaluate the efficacy and safety of combination therapy consisting of intermittent 5-FU and low-dose cisplatin in 26 patients with advanced or recurrent gastric cancer. The treatment cycle consisted of intravenous cisplatin at 3.3 mg/m(2)/day for 5 consecutive days. 5-FU was administered as a continuous intravenous infusion at 300-500 mg/body every other day (days 1, 3, 5) for 4 weeks.
  
  
  RESULTS
  The partial response rate was 34.6%. The median survival duration was 12.8 months and the one-year survival was 53.1%. There were a few adverse effects.
  
  
  CONCLUSIONS
  Our results suggest that this mode of combination therapy led to a fairly favorable outcome for patients with advanced or recurrent gastric cancer.
authors: Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. kanetaka@nagasaki-u.ac.jp
authors: Kengo
authors: K
authors: Kanetaka
authors: Akihito
authors: A
authors: Enjoji
authors: Junichiro
authors: J
authors: Furui
authors: Yasuhiro
authors: Y
authors: Nagata
authors: Hikaru
authors: H
authors: Fujioka
authors: Toshiaki
authors: T
authors: Shiogama
authors: Akimi
authors: A
authors: Miyata
authors: Hiroki
authors: H
authors: Kishikawa
authors: Shigetoshi
authors: S
authors: Matsuo
authors: Toru
authors: T
authors: Iwata
authors: Takashi
authors: T
authors: Kanematsu
authors: Susumu
authors: S
authors: Eguchi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002945:Cisplatin; D005472:Fluorouracil