title: Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women.
abstract: BACKGROUND
  An elevated annual incidence rate of hip fracture has been reported among elderly Taiwanese. Moreover, bone mineral density (BMD) is the single most reliable predictor of fragility fractures. We aimed to identify the association between gene sequence variants and hip BMD in postmenopausal Taiwanese women.
  
  
  METHODS
  We prospectively analyzed data from 163 postmenopausal Taiwanese women to test an association between rs7524102, rs6696981, or rs6993813 single-nucleotide polymorphisms (SNPs) and hip BMD.
  
  
  RESULTS
  Our study showed that rs6993813 (osteoprotegerin gene) and rs6696981 (ZBTB40 gene) SNPs have an opposite association with hip BMD. For rs6993813 genotypic frequencies, the adjusted odds ratio for hip osteoporosis was 9.53 for individuals with T/T minor allele homozygotes, compared with that of participants with C/C wild-type homozygotes. Hip BMD also had an association with rs6993813 SNPs, especially in T/T minor allele homozygotes. For rs6696981 SNPs, hip BMD in G/T heterozygotes and at least one mutated T allele was higher than that in wild-type G/G homozygotes.
  
  
  CONCLUSIONS
  The gene sequence variant rs6993813 reduced hip BMD and increased the risk of hip osteoporosis, whereas rs6696981 increased hip BMD in postmenopausal Taiwanese women. This indicated that the two SNPs may provide some explanation for the high risk of hip fracture in this population.
authors: Department of Orthopedics, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, ROC.
authors: Tai-Huang
authors: TH
authors: Chao
authors: Hsing-Ning
authors: HN
authors: Yu
authors: Chi-Chuan
authors: CC
authors: Huang
authors: Wen-Sheng
authors: WS
authors: Liu
authors: Ko-Hsiu
authors: KH
authors: Lu
mesh_terms: D000368:Aged; D015519:Bone Density; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006615:Hip; D006620:Hip Fractures / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D012189:Retrospective Studies; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; C576826:ZBTB40 protein, human