title: A multiple regression analysis on factors influencing haematopoietic progenitor cell collection for autologous transplantation.
abstract: Autologous hematopoietic stem cell (HSC) transplantation today is the standard treatment for a wide variety of haematological and oncological diseases. HSC are collected from peripheral blood by leukapheresis (HPC-A) following chemotherapy and/or growth factor-mediated mobilization. The ideal HPC-A collection allows to reach the CD34(+) target dose through a single, tailored leukapheresis. The aim of this paper was to find out which collection parameter might play a key role in obtaining a CD34 dose >4×10(6)/kg with a reduced number of leukapheresis. To address this issue, a multivariate logistic regression was carried out on several operational and laboratory parameters from 943 HPC-A collections performed in 600 hematological and oncological patients. We observed a CD34(+) cells collection efficiency (CE) >50% when patient's pre-apheresis total WBC count was lower than 12.5×10(6)/mL. At the same time, the likelihood of reaching the CD34(+) cells target dose/kg increased from 6 to 3 times when the pre-apheresis WBC count ×10(6)/mL t was below 4.3 (OR=6.1; 2.6-14.1) and between 4.3 and 7 (OR=2.8; 1.4-5.7) respectively when compared to a pre-apheresis WBC count >36×10(6)/mL.
authors: Therapeutic Apheresis Unit, Department of Transfusion Medicine, Pescara Civil Hospital, Pescara, Italy. patriziaaccorsi@virgilio.it
authors: Patrizia
authors: P
authors: Accorsi
authors: Cecilia
authors: C
authors: Passeri
authors: Antonio
authors: A
authors: Iacone
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D015999:Multivariate Analysis; D012044:Regression Analysis; D012189:Retrospective Studies; D014182:Transplantation, Autologous