title: Fetal evaluation of the modified-myocardial performance index in pregnancies complicated by diabetes.
abstract: OBJECTIVE
  To evaluate the fetal cardiac function by modified myocardial performance index (Mod-MPI) in pregnant diabetic patients.
  
  
  METHODS
  Modified myocardial performance index was measured in fetuses of patients with diabetes (DM) between 30 and 40 weeks of gestation. The isovolumetric contraction time, isovolumetric relaxation time and ejection time were measured. Mod-MPI was calculated as (isovolumetric contraction time + isovolumetric relaxation time)/ejection time. Results were analyzed by using one-way analysis of variance (post hoc Bonferroni correction), Chi-square and Student's test.
  
  
  RESULTS
  Modified myocardial performance index values of fetuses from DM mothers were significantly higher than controls (0.43 vs 0.37, P < 0.0001), and it was not different between gestational versus pregestational DM (0.42 vs 0.45, P = 0.18). Mod-MPI was also higher in the presence of polyhydramnios (0.49 vs 0.41, P < 0.0001), insulin use (0.46 vs 0.40, P < 0.05), and large for gestational age fetuses (0.49 vs 0.40, P < 0.0001). There were no significant differences in Mod-MPI between newborns with versus without neonatal complications such as hypoglycemia or polycythemia.
  
  
  CONCLUSIONS
  In fetuses of DM mothers, evaluation of the Mod-MPI identifies those with worse maternal disease and large fetal size.
authors: Department of Obstetrics & Gynecology and Laboratory of Reproductive Biology, Universidad de Los Andes, Chile. horaciofigueroa@miuandes.cl
authors: Horacio
authors: H
authors: Figueroa
authors: Maria Carolna
authors: MC
authors: Silva
authors: Cristian
authors: C
authors: Kottmann
authors: Sebastian
authors: S
authors: Viguera
authors: Ignacio
authors: I
authors: Valenzuela
authors: Edgar
authors: E
authors: Hernandez-Andrade
authors: Eduard
authors: E
authors: Gratacos
authors: Jose Antonio
authors: JA
authors: Arraztoa
authors: Sebastián E
authors: SE
authors: Illanes
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005865:Gestational Age; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D009200:Myocardial Contraction; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016216:Ultrasonography, Prenatal