title: Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins.
abstract: The first highly enantioselective decarboxylative addition of β-ketoacids to isatins mediated by a bifunctional tertiary amine-thiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing β-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates.
authors: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors: Fangrui
authors: F
authors: Zhong
authors: Weijun
authors: W
authors: Yao
authors: Xiaowei
authors: X
authors: Dou
authors: Yixin
authors: Y
authors: Lu
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D007651:Keto Acids / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D007211:Indoles; D007651:Keto Acids; D000078183:Oxindoles; C022960:2-oxindole; D007510:Isatin; D013890:Thiourea