title: Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells.
abstract: Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A(1)-A(6)) were investigated for their effects on growth and apoptosis in PC-3 human prostate cancer cells. The ability of these compounds to inhibit NF-κB activity in PC-3 cells was also determined. Five out of the six curcumin analogues (A(2)-A(6)) had stronger inhibitory effects compared to curcumin on the growth of cultured PC-3 cells. Compounds A(2)-A(6) also had stronger stimulatory effects on apoptosis in PC-3 cells than curcumin, and these curcumin analogues more potently inhibited NF-κB activity than curcumin. The inhibitory effects of these compounds on NF-κB activity correlated with their effects on growth inhibition and apoptosis stimulation in PC-3 cells. The results of the present study provide a rationale for in vivo studies with A(2)-A(6) using suitable animal models of prostate cancer.
authors: Department of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P.R. China.
authors: Xingchuan
authors: X
authors: Wei
authors: Zhi-Yun
authors: ZY
authors: DU
authors: Xiao-Xing
authors: XX
authors: Cui
authors: Michael
authors: M
authors: Verano
authors: Rong Qing
authors: RQ
authors: Mo
authors: Zhi Kai
authors: ZK
authors: Tang
authors: Allan H
authors: AH
authors: Conney
authors: Xi
authors: X
authors: Zheng
authors: Kun
authors: K
authors: Zhang