title: The hypothalamic-neurohypophyseal system: current and future treatment of vasopressin and oxytocyn related disorders.
abstract: The hypothalamus and posterior pituitary form a complex neurohumoral system playing a key role in maintaining body fluid homeostasis and reproductive function. We review the pathophysiology mechanisms of posterior pituitary hormones and their implications, beyond water balance and delivery, in social functioning, pair bonding and affiliative behavior. Actual and future treatments for neurohypophysis related disorders are also discussed, particularly focusing on the development of new therapeutic compounds and patents.
authors: IRCCS Centro Neurolesi Bonino-Pulejo, Via Palermo S.S. 113 98124 Messina, Italy. salbro77@tiscali.it
authors: Rocco S
authors: RS
authors: Calabrò
authors: Domenico
authors: D
authors: Italiano
authors: Danilo
authors: D
authors: Ferrara
authors: Stefania
authors: S
authors: Mondello
authors: Valeria
authors: V
authors: Conti-Nibali
authors: Carlo
authors: C
authors: Salviera
authors: Placido
authors: P
authors: Bramanti
mesh_terms: D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy / Q000503:physiopathology*; D008953:Models, Anatomic; D010121:Oxytocin / Q000502:physiology* / Q000627:therapeutic use; D010330:Patents as Topic; D014667:Vasopressins / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D014667:Vasopressins; D010121:Oxytocin