title: Lead bone toxicity in growing rats exposed to chronic intermittent hypoxia.
abstract: Lead chronic intoxication under hypoxic conditions revealed growth retardation in growing rats and damages on femoral and mandibular bones that predispose to fractures. These findings aimed us to investigate if bone material and geometric properties, bone mass in terms of histomorphometry or antioxidant capacity are also impaired in such experimental model. Combined treatments significantly reduced hemimandible cross sectional geometry and intrinsic stiffness (-16% and -34%); tibia and hemimandible bone volume (-45% and -40%) and growth plate cartilage thickness (-19%). These results show a previously unreported toxic effect of lead on mandible however, longer studies should be necessary to evaluate if an adaptation of bone architecture to maintain structural properties may occur and if the oxidative stress can be identified as the primary contributory agent in the pathogenesis of lead poisoning.
authors: Department of Physiology, University of Buenos Aires, MT Alvear 2142, 3rd. floor A, Buenos Aires, Argentina. miconti@fisio.odon.uba.ar
authors: María I
authors: MI
authors: Conti
authors: Clarisa
authors: C
authors: Bozzini
authors: Graciela B
authors: GB
authors: Facorro
authors: Ching M
authors: CM
authors: Lee
authors: Patricia M
authors: PM
authors: Mandalunis
authors: Lidia L
authors: LL
authors: Piehl
authors: Adriana E
authors: AE
authors: Piñeiro
authors: Antonela R
authors: AR
authors: Terrizzi
authors: María P
authors: MP
authors: Martínez
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D004785:Environmental Pollutants / Q000633:toxicity*; D005269:Femur / Q000187:drug effects / Q000254:growth & development*; D006132:Growth Plate; D000860:Hypoxia / Q000662:veterinary; D007854:Lead / Q000633:toxicity*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D013977:Tibia
chemical_list: D004785:Environmental Pollutants; D007854:Lead