title: Gemini imidazolium surfactants: synthesis and their biophysiochemical study.
abstract: New gemini imidazolium surfactants 9-13 have been synthesized by a regioselective epoxy ring-opening reaction under solvent-free conditions. The surface properties of these new gemini surfactants were evaluated by surface tension and conductivity measurements. These surfactants have been found to have low critical micelle concentration (cmc) values as compared to other categories of gemini cationic surfactants and also showed the tendency to form premicellar aggregates in solution at sufficiently low concentration below their cmc values. The thermal degradation of these surfactants was determined by thermograviometry analysis (TGA). These new cationic surfactants have a good DNA binding capability as determined by agarose gel electrophoresis and ethidium bromide exclusion experiments. They have also been found to have low cytotoxicity by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on the C6 glioma cell line.
authors: Department of Chemistry, UGC Sponsored-Centre of Advance Studies-1, Guru Nanak Dev University, Amritsar, India.
authors: Raman
authors: R
authors: Kamboj
authors: Sukhprit
authors: S
authors: Singh
authors: Avinash
authors: A
authors: Bhadani
authors: Hardeep
authors: H
authors: Kataria
authors: Gurcharan
authors: G
authors: Kaur
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D060326:Chemistry Techniques, Synthetic; D004996:Ethidium / Q000737:chemistry; D055772:Green Chemistry Technology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D008823:Micelles; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D014867:Water / Q000737:chemistry
chemical_list: D007093:Imidazoles; D008823:Micelles; D013501:Surface-Active Agents; D014867:Water; D004996:Ethidium