title: Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.
abstract: The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.
authors: Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.
authors: S S
authors: SS
authors: Jankauskas
authors: E Y
authors: EY
authors: Plotnikov
authors: M A
authors: MA
authors: Morosanova
authors: I B
authors: IB
authors: Pevzner
authors: L D
authors: LD
authors: Zorova
authors: V P
authors: VP
authors: Skulachev
authors: D B
authors: DB
authors: Zorov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D005839:Gentamicins / Q000009:adverse effects; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009925:Organ of Corti / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats; D051437:Renal Insufficiency / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D012235:Rhodamines / Q000008:administration & dosage*
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; D000975:Antioxidants; D005839:Gentamicins; D012235:Rhodamines; D010971:Plastoquinone