title: No harmful effect of mycophenolate mofetil on liver regeneration: an experimental study.
abstract: OBJECTIVE
  The aim of this experimental study was to examine the effects of mycophenolate mofetil (MMF) on liver regeneration in a partial hepatectomy model.
  
  
  METHODS
  Rats were divided into 3 groups immediately following partial liver resection: saline, controls intraperitoneally (MMF; Group 1); MMF (15 mg/kg/d; Group II), and MMF (30 mg/kg/d; Group III). On days 3 and 7 following liver resection we humanely killed half of the rats in each group to measure alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and to evaluate Ki-67 using immunohistochemistry. We calculated liver regeneration rates.
  
  
  RESULTS
  The difference between ALT levels on days 3 and 7 was not significantly different among the groups (P = .157; P = .292; P > .05, respectively). The AST levels were significantly different at 3 days (P = .018) but not 7 days (P = .385). The Ki-67 level were different among groups at day 3 (P = .002) but not at day 7 (P = .290). Liver regeneration rates were not different among the groups either at 3 or at 7 days (P = .264 and P = .925, respectively).
  
  
  CONCLUSIONS
  MMF stimulates mitosis but its effect on regeneration is not clear. MMF appeared to show no adverse effects on liver regeneration.
authors: Department of General Surgery, Kartal Research and Education Hospital, Kartal-Istanbul, Turkey.
authors: M
authors: M
authors: Demiray
authors: H F
authors: HF
authors: Kucuk
authors: M
authors: M
authors: Yildirim
authors: N O
authors: NO
authors: Barisik
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006498:Hepatectomy; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000633:toxicity; D019394:Ki-67 Antigen / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D023421:Models, Animal; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D019394:Ki-67 Antigen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009173:Mycophenolic Acid