title: Synthesis, self-aggregation and bioactivity properties of a cationic aminoacyl surfactant, based on a new class of highly functionalized nucleolipids.
abstract: A highly functionalized aminoacyl nucleolipid based on uridine is here proposed as a novel cationic surfactant. To achieve this, a straightforward, high yielding and versatile protocol has been devised, in principle providing synthetic access to a variety of different, related analogs. Self-aggregation properties of this nucleolipid were determined by using a combined approach, including surface tension, conductivity and DLS measurements. Above the critical micellar concentration of 4 × 10(-5) mol kg(-1), large supramolecular assemblies with a counterion condensation degree of 0.25 were observed. The bioactivity profile of this new compound was investigated on cancer and non cancer cell lines.
authors: Dipartimento di Scienze Chimiche, Università di Napoli "Federico II", Complesso Universitario di Monte S. Angelo, via Cintia, 4, I-80126 Napoli, Italy.
authors: Luca
authors: L
authors: Simeone
authors: Carlo
authors: C
authors: Irace
authors: Antonio
authors: A
authors: Di Pascale
authors: Donato
authors: D
authors: Ciccarelli
authors: Gerardino
authors: G
authors: D'Errico
authors: Daniela
authors: D
authors: Montesarchio
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004553:Electric Conductivity; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D008823:Micelles; D051381:Rats; D055672:Static Electricity; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry*; D014529:Uridine / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008055:Lipids; D008823:Micelles; D013501:Surface-Active Agents; D014529:Uridine