title: Assessment of bone healing and hypoesthesia in the upper lip after Le Fort I osteotomy with self-setting α-tricalcium phosphate and absorbable plates.
abstract: OBJECTIVE
  The purpose of this study was to evaluate hypoesthesia of the upper lip and bone formation using self-setting α-tricalcium phosphate (Biopex(®)) between the segments following Le Fort I osteotomy with bent absorbable plate fixation.
  
  
  METHODS
  The subjects were 47 patients (94 sides) who underwent Le Fort I osteotomy with and without mandibular osteotomy. They were divided into a Biopex(®) group (48 sides) and a control group (46 sides). The Biopex(®) was inserted into the anterior part of the gap between the segments in the Biopex(®) group. Trigeminal nerve hypoesthesia at the region of the upper lip was assessed bilaterally by the trigeminal somatosensory-evoked potential (TSEP) method. The area of the Biopex(®) at the anterior part in the maxilla was assessed immediately after surgery and 1 year postoperatively by computed tomography (CT).
  
  
  RESULTS
  The mean measurable period and standard deviation were 13.2 ± 18.5 weeks in the control group, 14.5 ± 17.9 weeks in the Biopex(®) group, and there was no significant difference in TSEP. The area of the Biopex(®) after 1 year was significantly smaller than that immediately after surgery (right side: P = 0.0024, left side: P = 0.0001) and bone defects between the segments could not be found in the Biopex(®) group. In the control group, although the areas of bone defect after 1 year were significantly smaller than that immediately after surgery on the right side (P = 0.0133) and left side (P = 0.0469) in the frontal view, complete healing of the bone defects could be seen in 12 of 46 sides after 1 year.
  
  
  CONCLUSIONS
  This study suggested that inserting Biopex(®) in the gap between the maxillary segments was useful for new bone formation and it did not prevent the recovery of upper lip hypoesthesia after Le Fort I osteotomy with absorbable plate fixation.
authors: Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan. kueki@med.kanazawa-u.ac.jp
authors: Koichiro
authors: K
authors: Ueki
authors: Katsuhiko
authors: K
authors: Okabe
authors: Kohei
authors: K
authors: Marukawa
authors: Aya
authors: A
authors: Mukozawa
authors: Akinori
authors: A
authors: Moroi
authors: Mao
authors: M
authors: Miyazaki
authors: Megumi
authors: M
authors: Sotobori
authors: Yuri
authors: Y
authors: Ishihara
authors: Kunio
authors: K
authors: Yoshizawa
authors: Kazuhiro
authors: K
authors: Ooi
authors: Shuichi
authors: S
authors: Kawashiri
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001860:Bone Plates; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006987:Hypesthesia / Q000209:etiology*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008047:Lip Diseases / Q000209:etiology*; D008297:Male; D063168:Mandibular Osteotomy / Q000379:methods; D063166:Maxillary Osteotomy / Q000379:methods*; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures / Q000379:methods; D010012:Osteogenesis / Q000502:physiology; D019340:Osteotomy, Le Fort / Q000379:methods*; D059229:Osteotomy, Sagittal Split Ramus / Q000379:methods; D011183:Postoperative Complications; D011378:Prognathism / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D020433:Trigeminal Nerve Diseases / Q000209:etiology; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate