title: Xanthine oxidase inhibitors from Vietnamese Blumea balsamifera L.
abstract: From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(-)-4'-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1-4 and 6-8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC₅₀ values ranging from 0.23 to 1.91 µM, than that of a positive control allopurinol (IC₅₀ 2.50 µM).
authors: Faculty of Chemistry, University of Science, Vietnam National University, HoChiMinh City, Vietnam. nttmai@hcmus.edu.vn
authors: Mai Thanh Thi
authors: MT
authors: Nguyen
authors: Nhan Trung
authors: NT
authors: Nguyen
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D005591:Chemical Fractionation; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D000432:Methanol; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: C576484:(2R,3S)-(-)-4'-O-methyldihydroquercetin; D004791:Enzyme Inhibitors; D005419:Flavonoids; D010936:Plant Extracts; C459210:quercetin 3-O-methyl ether; D011794:Quercetin; D014969:Xanthine Oxidase; D000432:Methanol