title: Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia.
abstract: BACKGROUND
  White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SIVD-WMH) with 17 controls to investigate physiological changes underlying this diagnosis.
  
  
  RESULTS
  Differences between the groups were large, with a decrease of relative power of fast activity in patients (alpha power 0.25 ± 0.12 versus 0.38 ± 0.13, p = 0.01; beta power 0.08 ± 0.04 versus 0.19 ± 0.07; p<0.001) and an increase in relative powers of slow activity in patients (theta power 0.32 ± 0.11 versus 0.14 ± 0.09; p<0.001 and delta power 0.31 ± 0.14 versus 0.23 ± 0.09; p<0.05). Lower relative beta power was related to worse cognitive performance in a linear regression analysis (standardized beta = 0.67, p<0.01).
  
  
  CONCLUSIONS
  This pattern of disturbance in oscillatory brain activity indicate loss of connections between neurons, providing a first step in the understanding of cognitive dysfunction in SIVD-WMH.
authors: Department of Clinical Neurophysiology, VU University Medical Center, de Boelelaan 1118, Amsterdam, 1081 HV, Netherlands. i.vanstraaten@vumc.nl
authors: Elisabeth C W
authors: EC
authors: van Straaten
authors: Willem
authors: W
authors: de Haan
authors: Hanneke
authors: H
authors: de Waal
authors: Philip
authors: P
authors: Scheltens
authors: Wiesje M
authors: WM
authors: van der Flier
authors: Frederik
authors: F
authors: Barkhof
authors: Ted
authors: T
authors: Koene
authors: Cornelis J
authors: CJ
authors: Stam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001683:Biological Clocks / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D015140:Dementia, Vascular / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D013057:Spectrum Analysis