title: Antioxidant activities of chokeberry extracts and the cytotoxic action of their anthocyanin fraction on HeLa human cervical tumor cells.
abstract: The present study evaluates the antioxidant activity of two Aronia melanocarpa cultivars-Viking and Aron-and of Aronia prunifolia hybrid in relationship with their phytochemical composition regarding the contents of total phenolics, flavonoids, procyanidins, and monomeric anthocyanins. The antioxidant capacity of the mentioned extracts of chokeberries was evaluated through five complementary assays: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), H(2)O(2) scavenging potential, oxygen radical absorbance capacity, ferric reducing antioxidant power, and cupric ion reducing antioxidant capacity. A. prunifolia hybrid was found to have the highest antioxidant activity and to be the richest in polyphenols, procyanidins, and anthocyanins compared with the A. melanocarpa cultivars. A good correlation was observed between antioxidant activity and total procyanidin and anthocyanin content. Cyanidin glycosides inhibited HeLa human cervical tumor cell proliferation and increased generation of reactive oxygen species after 48 h of treatment, suggesting that they could be responsible for the antiproliferative activity. These results may be significant for industry concerning food quality and disease prevention.
authors: Department of Chemistry and Biochemistry, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
authors: Dumitriţa
authors: D
authors: Rugină
authors: Zoriţa
authors: Z
authors: Sconţa
authors: Loredana
authors: L
authors: Leopold
authors: Adela
authors: A
authors: Pintea
authors: Andrea
authors: A
authors: Bunea
authors: Carmen
authors: C
authors: Socaciu
mesh_terms: D000872:Anthocyanins / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D046936:Photinia / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D003603:Cytotoxins; D010936:Plant Extracts; D017382:Reactive Oxygen Species