title: Coherence-multiplexed, label-free biomolecular interaction analysis.
abstract: This Letter describes an interferometric technique based on the principle of coherence multiplexing for multichannel, label-free biosensing applications. Multiple biosensors can be interrogated simultaneously with a single spectral-domain, phase-sensitive interferometer by coding the individual sensograms in coherence-multiplexed channels. The experimental results demonstrate the multiplexed quantitative biomolecular interaction of antibodies binding to antigen-coated functionalized biosensor chip surfaces. The described technique also applies to a variety of other distributed and multiplexed sensing applications besides biosensing.
authors: Department of Bioengineering, University of Texas, Arlington, Texas 76010, USA.
authors: Sajal
authors: S
authors: Chirvi
authors: Zexuan
authors: Z
authors: Qiang
authors: Digant P
authors: DP
authors: Davé
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D002417:Cattle; D007118:Immunoassay; D007074:Immunoglobulin G / Q000276:immunology; D007368:Interferometry
chemical_list: D007074:Immunoglobulin G