title: Genetics of rheumatoid arthritis: an impressionist perspective.
abstract: Rheumatoid arthritis (RA) is the most common rheumatic disease. The genetic basis of RA is supported through the identification of more than 30 susceptibility genetic variants. Each of these genes individually makes only a slight contribution to the risk of disease. Moreover, there is significant disparity in the genetic variants associated with different RA subgroups and patient ethnicities, which emphasizes the intricate nature of the disease's pathogenesis, and the complexities involved in large-scale genetic studies. This review evaluates critically the recent literature on the genetic contribution to RA and assesses the methodology used to identify these risk alleles.
authors: Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue HMR 703, Los Angeles, CA 90033, USA. jacob@usc.edu
authors: Noam
authors: N
authors: Jacob
authors: Chaim O
authors: CO
authors: Jacob
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015234:HLA-A Antigens / Q000235:genetics; D006801:Humans; D020412:Multifactorial Inheritance; D012307:Risk Factors
chemical_list: D015234:HLA-A Antigens