title: Maintaining poise: commensal microbiota calibrate interferon responses.
abstract: The mechanisms of how commensal bacteria impact systemic immunity are unclear. In this issue of Immunity, Abt et al. (2012) and Ganal et al. (2012) demonstrate that microbiota poise macrophages for induction of the type I interferon pathway after virus infection.
authors: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
authors: Jeremy P
authors: JP
authors: McAleer
authors: Jay K
authors: JK
authors: Kolls