title: Successful pregnancy after fertility-sparing local resection and uterine reconstruction for low-grade endometrial stromal sarcoma.
abstract: BACKGROUND
  Fertility-sparing management of endometrial stromal sarcoma has been demonstrated, but reports of pregnancy after such management are rare in our current body of literature.
  
  
  METHODS
  A 16-year-old nulligravid adolescent girl presented with symptoms of menometrorrhagia and was found to have a 17-cm uterine mass. The patient underwent local resection of the mass with uterine reconstruction. Pathology revealed a low-grade endometrial stromal sarcoma. She was placed on high-dose daily megestrol acetate therapy and remained disease-free for 8 years before achieving pregnancy spontaneously. The patient underwent an uncomplicated pregnancy until 34 weeks of gestation, when she presented in preterm labor and underwent cesarean delivery of a liveborn male neonate, with no evidence of disease recurrence.
  
  
  CONCLUSIONS
  Fertility-sparing management and close follow-up of low-grade endometrial stromal sarcoma may be a viable option for those desiring future fertility.
authors: From the Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska; and the Halifax Health Center for Oncology, Daytona Beach, Florida.
authors: Abigail A
authors: AA
authors: Delaney
authors: Ashley L
authors: AL
authors: Gubbels
authors: Steve
authors: S
authors: Remmenga
authors: Paul
authors: P
authors: Tomich
authors: Kelly
authors: K
authors: Molpus
mesh_terms: D000293:Adolescent; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D002585:Cesarean Section; D017024:Chemotherapy, Adjuvant; D036821:Endometrial Stromal Tumors / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D019290:Megestrol Acetate / Q000008:administration & dosage*; D008595:Menorrhagia / Q000209:etiology; D011184:Postoperative Period; D011247:Pregnancy; D011256:Pregnancy Outcome; D019651:Plastic Surgery Procedures; D018203:Sarcoma, Endometrial Stromal / Q000175:diagnosis / Q000601:surgery*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D019290:Megestrol Acetate