title: Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson's disease.
abstract: BACKGROUND
  NR4A2 gene is a transcription factor crucial for differentiation and survival of midbrain dopamine (DA) neurons, and several variants have been eported to be associated with Parkinson's disease (PD) in the Caucasian population.
  
  
  METHODS
  To determine whether there is any association of NR4A2 mutation or variation with PD in the Han Chinese population, we performed a genetic analysis of all the exons and exon-intron boundaries in 689 PD patients and 672 controls from mainland China using direct sequencing analysis.
  
  
  RESULTS
  We identified four novel variants and two previously reported variants. Two novel variants (exon 2 c.-20 C>G and exon 3 c.711 C>A) were only found in PD. The others (exon 2 c.-35 A>G; exon 8 c.1615 G>A; intron 4 IVS4-16 G>T; and intron 6 IVS6 + 18 insG) were found in both PD and controls at different frequencies.
  
  
  CONCLUSIONS
  Collectively, our results suggest that NR4A2 may be a susceptibility gene for PD in the Chinese population.
authors: Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: H
authors: H
authors: Liu
authors: Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Q
authors: Q
authors: Tao
authors: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha, China.
authors: H
authors: H
authors: Deng
authors: Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: M
authors: M
authors: Ming
authors: Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Y
authors: Y
authors: Ding
authors: Department of Neurology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: P
authors: P
authors: Xu
authors: Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: S
authors: S
authors: Chen
authors: Department of Neurology, Third Xiangya Hospital, Central South University, Changsha, China.
authors: Z
authors: Z
authors: Song
authors: Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: W
authors: W
authors: Le
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2 / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*
chemical_list: C539882:NR4A2 protein, human; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2