title: The relation between visual performance and clinical ocular manifestations in Stevens-Johnson syndrome.
abstract: OBJECTIVE
  To investigate the relation between visual function, clinical findings, and visual symptoms in Stevens-Johnson syndrome (SJS) and to compare the results with Sjögren syndrome (SS) patients and normal subjects.
  
  
  METHODS
  Cross-sectional comparative study.
  
  
  METHODS
  One hundred fifteen eyes of 59 consecutive patients with SJS and toxic epidermal necrolysis (TEN), 208 eyes of 104 healthy normal subjects, and 132 eyes of 66 SS patients were investigated in this multicenter study. All study subjects underwent tear function and ocular surface examinations, Landolt and functional visual acuity examinations, and the Japanese version of the NEI VFQ-25 (National Eye Institute Visual Function Questionnaire).
  
  
  RESULTS
  The mean ocular surface grading scores were significantly higher and the mean score of all 12 NEI VFQ subscales was significantly lower in the SJS patients compared to the SS patients and the normal subjects (P < .05). The conventional and functional logarithm of minimal angle of resolution (logMAR) visual acuities in SJS patients with minimal corneal complications were significantly higher and the mean total composite NEI VFQ scores were lower compared to SS patients. The conventional and functional logMAR visual acuities and the mean ocular surface grading scores in SJS with aqueous deficiency were significantly higher and the mean total composite NEI VFQ scores were lower compared to SS patients. Strong correlations between best-corrected logMAR functional visual acuities and either ocular surface grading scores or the composite NEI VFQ-25 scores were observed.
  
  
  CONCLUSIONS
  The functional visual acuity examination reflects the severity of clinical ocular surface findings and vision-related quality of life more than the standard conventional visual acuity in SJS.
authors: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan. fwiw1193@mb.infoweb.ne.jp
authors: Minako
authors: M
authors: Kaido
authors: Masakazu
authors: M
authors: Yamada
authors: Chie
authors: C
authors: Sotozono
authors: Shigeru
authors: S
authors: Kinoshita
authors: Jun
authors: J
authors: Shimazaki
authors: Yoshitsugu
authors: Y
authors: Tagawa
authors: Yuko
authors: Y
authors: Hara
authors: Taiichiro
authors: T
authors: Chikama
authors: Kazuo
authors: K
authors: Tsubota
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D018434:Sickness Impact Profile; D012859:Sjogren's Syndrome / Q000503:physiopathology*; D013262:Stevens-Johnson Syndrome / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013666:Tears / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult