title: Polymer micelles for delayed release of therapeutics from drug-releasing surfaces with nanotubular structures.
abstract: A new approach to engineer a local drug delivery system with delayed release using nanostructured surface with nanotube arrays is presented. TNT arrays electrochemically generated on a titanium surface are used as a model substrate. Polymer micelles as drug carriers encapsulated with drug are loaded at the bottom of the TNT structure and their delayed release is obtained by loading blank micelles (without drug) on the top. The delayed and time-controlled drug release is successfully demonstrated by controlling the ratio of blank and drug loaded-micelles. The concept is verified using four different polymer micelles (regular and inverted) loaded with water-insoluble (indomethacin) and water-soluble drugs (gentamicin).
authors: Ian Wark Research Institute, University of South Australia, Mawson Lakes Boulevard, Adelaide, SA 5095, Australia.
authors: Moom
authors: M
authors: Sinn Aw
authors: Jonas
authors: J
authors: Addai-Mensah
authors: Dusan
authors: D
authors: Losic
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D055664:Electrochemical Techniques; D005839:Gentamicins / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007213:Indomethacin / Q000737:chemistry; D007700:Kinetics; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D012995:Solubility; D013386:Succinates / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*; D014810:Vitamin E / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005839:Gentamicins; D008823:Micelles; C116176:PEO-PPO-PEO; D011409:Propylene Glycols; D013386:Succinates; D020442:Poloxamer; D014810:Vitamin E; D011092:Polyethylene Glycols; D014025:Titanium; C014225:tocophersolan; D007213:Indomethacin