title: Monte Carlo mitochondrial dosimetry and microdosimetry of 131I.
abstract: A mitochondrion is an organelle found in most eukaryotic cells, which produces most of the energy needed by a living cell. It has been shown that ionising radiation causes mitochondrial damage leading to apoptosis or cell death. The aim of this work was to calculate, by Monte Carlo simulation, the specific energy (z) into the mitochondria, due to Auger electrons, conversion electrons and beta emission from (131)I, where the radionuclide was carried by a vector to the cell surface and the surrounding environment. A concentric spherical geometry represents a cell and its nucleus. Three different volumes were used to represent the mitochondria; they were placed in random positions within the cytoplasm. The z produced by a single event is due to low-energy electrons (76 %) and beta particles (24 %) and the mitochondria receive a total mean z two orders of magnitude higher than that of the cell nucleus.
authors: Laboratorio de Simulación Monte Carlo, Coordinación de Posgrado, Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan s/n, esquina Jesús Carranza, Colonia Moderna de la Cruz, Toluca, Estado de México, México.
authors: Tomás A
authors: TA
authors: Carrillo-Cázares
authors: Eugenio
authors: E
authors: Torres-García
mesh_terms: D000465:Algorithms; D002467:Cell Nucleus / Q000528:radiation effects; D003198:Computer Simulation; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D006801:Humans; D007457:Iodine Radioisotopes / Q000032:analysis*; D008928:Mitochondria / Q000528:radiation effects*; D009010:Monte Carlo Method; D011874:Radiometry / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes; D004247:DNA