title: Variation of serum C-reactive protein (CRP) over time in pediatric cancer patients with febrile illness and its relevance to identified pathogen.
abstract: OBJECTIVE
  To evaluate the correlation of serum CRP with clinical and laboratory parameters proven to be related to the cause of infection in pediatric cancer patients.
  
  
  METHODS
  We studied prospectively for a 12-month period, 37 pediatric cancer patients, who presented with 70 episodes of febrile illness (38 bacterial and 13 viral infections). At fever's onset and 48 h later, infection indices, such as CRP, WBC, ANC were measured in the peripheral blood. Moreover we calculated the change rate of CRP over 48 h [CRP/t=(CRP48h-initial CRP)/t (t=2 days)]. Cultures of biological fluids, PCR and antibody detection of infectious agents were also obtained.
  
  
  RESULTS
  When comparing patients with viral vs. bacterial infections, mean CRP levels on admission (11.0 vs. 33.1mg/L, p=0.005) and at 48 h (13.4 vs. 71.9 mg/L, p=0.0007), and CRP/t (0.9 vs. 18.8 mg/L/day, p=0.030) were significantly lower in the group with viral infection. At 48 h - follow-up, patients with positive culture had higher CRP levels (57.3 vs. 43.3mg/L, p=0.048) and higher CRP/t (15.9 vs. 7.7 mg/L/day, p=0.025), compared to those without proven infection. CRP/t at 48 h was correlated with both the fever duration (r=0.27, p=0.027) and maximum temperature (Tmax) during the febrile episode (r=0.30, p=0.013).
  
  
  CONCLUSIONS
  Single CRP values on fever initiation can differentiate between viral and bacterial infections in febrile pediatric cancer patients. Moreover the change rate of CRP over time (CRP/t) is offered as a prognostic index of bacterial infection and a marker of the total duration of fever and Tmax.
authors: Department of Pediatric Hematology-Oncology, Aghia Sofia Children's Hospital, Athens, Greece. riginagr@yahoo.gr
authors: Rigina
authors: R
authors: Sklavou
authors: Kyriaki
authors: K
authors: Karavanaki
authors: Eleni
authors: E
authors: Critselis
authors: Lydia
authors: L
authors: Kossiva
authors: Maria
authors: M
authors: Giannaki
authors: Maria
authors: M
authors: Tsolia
authors: Vassilis
authors: V
authors: Papadakis
authors: Sophia
authors: S
authors: Papargyri
authors: Antonia
authors: A
authors: Vlachou
authors: Fotis
authors: F
authors: Karantonis
authors: Dimitris
authors: D
authors: Gourgiotis
authors: Sophia
authors: S
authors: Polychronopoulou
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000097:blood* / Q000382:microbiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000097:blood* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D009181:Mycoses / Q000097:blood* / Q000382:microbiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications*; D011446:Prospective Studies; D012044:Regression Analysis; D014777:Virus Diseases / Q000097:blood* / Q000821:virology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein