title: Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.
abstract: Alpha-lipoic acid (ALA), a natural antioxidant, is widely used for the treatment of some diseases including diabetes, and decursinol (DA), a constituent of root of Angelica gigas Nakai, has some pharmacological activities including anti-inflammatory function. In this study, we synthesized a novel synthetic alpha-lipoic acid-decursinol (ALA-DA) hybrid compound, and compared neuroprotective effects of ALA, DA or ALA-DA against ischemic damage in the gerbil hippocampal CA1 region induced by 5 min of transient cerebral ischemia. In the 10 and 20 mg/kg ALA-, DA- and 10 mg/kg ALA-DA-pre-treated-ischemia-groups, there were no neuroprotective effects against ischemic damage 4 days after ischemic injury. However, 20 mg/kg ALA-DA pre-treatment protected pyramidal neurons from ischemic damage in the CA1 region. In addition, 20 mg/kg ALA-DA pre-treatment markedly decreased the activation of astrocytes and microglia in the CA1 region 4 days after ischemic injury. On the other hand, post-treatment with the same dosages of them did not show any neuroprotective effect against ischemic damage. In brief, these findings indicate that pre-treatment with ALA-DA, not ALA or DA alone, can protect neurons from ischemic damage in the hippocampus induced by transient cerebral ischemia via the decrease of glial activation.
authors: Department of Emergency Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, South Korea.
authors: Tae Hun
authors: TH
authors: Lee
authors: Joon Ha
authors: JH
authors: Park
authors: Jong-Dai
authors: JD
authors: Kim
authors: Jae-Chul
authors: JC
authors: Lee
authors: In Hye
authors: IH
authors: Kim
authors: Yongbae
authors: Y
authors: Yim
authors: Seul Ki
authors: SK
authors: Lee
authors: Bing Chun
authors: BC
authors: Yan
authors: Ji Hyeon
authors: JH
authors: Ahn
authors: Choong Hyun
authors: CH
authors: Lee
authors: Ki-Yeon
authors: KY
authors: Yoo
authors: Jung Hoon
authors: JH
authors: Choi
authors: In Koo
authors: IK
authors: Hwang
authors: Jeong Ho
authors: JH
authors: Park
authors: Moo-Ho
authors: MH
authors: Won
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D008063:Thioctic Acid / Q000138:chemical synthesis / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D008063:Thioctic Acid