title: Automated hippocampal subfields segmentation in late life depression.
abstract: Although a few automated hippocampal subfields segmentation methods have been developed, there has been no in vivo Magnetic Resonance Imaging (MRI) study on the hippocampal subfields volumes of Late Life Depression (LLD). The aim of this study was to investigate the hippocampal subfields volume differences between LLD subjects and healthy elderly controls using an automated hippocampal subfields segmentation technique. Thirty subjects with LLD and 30 group-matched healthy control subjects underwent 3T MRI scanning, and hippocampal subfields volumes were measured and compared between the groups. Subjects with LLD exhibited significant hippocampal volume reductions in the total hippocampus, subiculum, and Cornu Ammonis (CA) 2-3 areas compared with healthy subjects (uncorrected, p<0.001). This study is the first to elaborate the subfields volume differences of both hippocampi between controls and LLD patients. These structural changes in the hippocampal presubiculum, subiculum, and CA2-3 areas might be at the core of the underlying neurobiological mechanisms of hippocampal dysfunction in LLD.
authors: Department of Psychiatry, The Saint Vincent Hospital, Suwon, The College of Medicine, The Catholic University of Korea, Republic of Korea.
authors: Hyun Kook
authors: HK
authors: Lim
authors: Seung Chul
authors: SC
authors: Hong
authors: Won Sang
authors: WS
authors: Jung
authors: Kook Jin
authors: KJ
authors: Ahn
authors: Wang Youn
authors: WY
authors: Won
authors: Changtae
authors: C
authors: Hahn
authors: InSeong
authors: I
authors: Kim
authors: Chang Uk
authors: CU
authors: Lee
mesh_terms: D000368:Aged; D056651:CA2 Region, Hippocampal / Q000473:pathology; D056654:CA3 Region, Hippocampal / Q000473:pathology; D016022:Case-Control Studies; D003863:Depression / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size