title: Corynebacterium spp. in dogs and cats with otitis externa and/or media: a retrospective study.
abstract: The role of Corynebacterium spp. in the pathogenesis of canine and feline otitis externa/media and their appropriate antimicrobial therapy are unclear. The objectives of this study were to (1) better establish the pathogenicity of Corynebacterium spp. in otitis utilizing reported criteria and by assessing clinical response to antibiotic therapy and (2) to determine the antimicrobial susceptibility patterns of Corynebacterium spp. associated with otitis. The study was retrospective, targeting cultures positive for Corynebacterium spp. Corynebacterium spp. were part of mixed microbial populations in 79/81 cultures. Corynebacterium spp. pathogenicity was highly questionable because of their almost invariable presence with other microbes and the observation that Corynebacterium spp. usually disappear from the ear with resolution of other infections, even when the Corynebacterium spp. are resistant to the prescribed antibiotic(s). However, 2/81 cultures came from two canine ears wherein Corynebacterium spp. may have been pathogenic. Antimicrobial sensitivities for Corynebacterium spp. were available for 54 isolates. Most isolates were susceptible to chloramphenicol (53/54), amikacin (50/54), tetracycline (50/54), gentamicin (46/54), and enrofloxacin (32/54). Among those antibiotics available in otic products, gentamicin and enrofloxacin would be rational choices for the empirical, topical therapy of Corynebacterium spp.
authors: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. khenneveld@googlemail.com
authors: Kerstin
authors: K
authors: Henneveld
authors: Rodney A W
authors: RA
authors: Rosychuk
authors: Francisco J
authors: FJ
authors: Olea-Popelka
authors: Doreene R
authors: DR
authors: Hyatt
authors: Sonja
authors: S
authors: Zabel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000382:microbiology*; D002415:Cats; D003352:Corynebacterium; D003354:Corynebacterium Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology*; D004285:Dogs; D024881:Drug Resistance, Bacterial; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests; D010032:Otitis Externa / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents