title: Bioactive aldehyde-modified phosphatidylethanolamines.
abstract: Lipid peroxidation generates a variety of lipid aldehydes, which have been recognized to modify protein and DNA, causing inflammation and cancer. However, recent studies demonstrate that phosphatidylethanolamine (PE) is a major target for these aldehydes, forming aldehyde-modified PEs (al-PEs) as a novel family of mediators for inflammation. This review summarizes our current understanding of these al-PEs, including formation, detection, structural characterization, physiological relevance and mechanism of action.
authors: Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, TN 37232-6602, USA. lilu.guo@vanderbilt.edu
authors: Lilu
authors: L
authors: Guo
authors: Sean S
authors: SS
authors: Davies
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation; D015394:Molecular Structure; D018384:Oxidative Stress; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D000447:Aldehydes; D010714:Phosphatidylethanolamines; D017382:Reactive Oxygen Species