title: [Level of evidence for therapeutic drug monitoring of ceftriaxone].
abstract: Ceftriaxone is a third generation cephalosporin with an original pharmacokinetics based on a long elimination half-life among cephalosporins, a high protein binding and a dual renal and biliary elimination. Also the pharmacokinetic parameters of ceftriaxone are highly variable in clinical situations such as severe renal insufficiency, liver and renal insufficiency, the elderly, the neonates less than 1 week of age and critically ill patients. In these clinical situations associated or not with high minimal inhibitory concentration (MIC) level, the relationship concentration-clinical outcome based on the ratio between trough plasma concentration and MIC can allow a dose adjustment. Consequently, therapeutic drug monitoring (TDM) of ceftriaxone could be possibly useful in these situations, whereas the necessity of TDM has still to be demonstrated to monitor toxicity.
authors: Service de Pharmacologie Clinique, CHU de Nantes, Nantes, France. eric.dailly@chu-nantes.fr
authors: Eric
authors: E
authors: Dailly
authors: Marie-Clémence
authors: MC
authors: Verdier
authors: Guillaume
authors: G
authors: Deslandes
authors: Régis
authors: R
authors: Bouquié
authors: Olivier
authors: O
authors: Tribut
authors: Danièle
authors: D
authors: Bentué-Ferrer
mesh_terms: D000375:Aging / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002443:Ceftriaxone / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016638:Critical Illness; D016903:Drug Monitoring; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone