title: [Crosstalk between central and peripheral biological clocks].
abstract: Mammalian circadian system is multi-oscillator system. Clock gene expression analysis revealed that central clock, suprachiasmatic nucleus, organizes and synchronizes the peripheral oscillators in the whole body cells. Similarly, human circadian system is considered to be dual oscillation system because of internal desynchronization between melatonin, body temperature rhythms(driven by oscillator I) and sleep-wake rhythm (driven by oscillator II) under temporal isolation of dim light conditions. These oscillators control their periods mutually which means there is crosstalk of oscillators. Although the effect from oscillator II to oscillator I is weak under experimental dim light conditions, sleep-wake behavior controls light input to light sensitive oscillator I and feedbacks to sleep-wake driving oscillator II under lighting condition we live. To understand these mechanisms is important for prevention of circadian rhythm related diseases.
authors: The Matching Program for Innovations in Future Drug Discovery and Medical Care, Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine.
authors: Satoru
authors: S
authors: Masubuchi
authors: Yohko
authors: Y
authors: Suzuki
authors: Sato
authors: S
authors: Honma
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008027:Light; D008550:Melatonin / Q000378:metabolism; D012890:Sleep / Q000502:physiology
chemical_list: D008550:Melatonin