title: Langerhans cell histiocytosis in children born 1982-2005 after in vitro fertilization.
abstract: OBJECTIVE
  In a recent Swedish study, comparing data from the Swedish Cancer Register with the Medical Birth Register including data on IVF, an increased risk of Langerhans cell histiocytosis (LCH) was found in children born 1982-2005 after IVF. Here, we aimed to verify the LCH diagnoses and examine whether any special forms of the disease were overrepresented in this population.
  
  
  METHODS
  Medical records for all children with LCH conceived by IVF were acquired and the diagnosis confirmed or discarded. Disease characteristics were compared with data from children diagnosed with LCH 1992-2001 in the Stockholm County.
  
  
  RESULTS
  We verified LCH in seven children born after IVF, all born prior to 2002. These children did not have milder disease forms. The odds ratio (OR) to develop LCH for the whole group born after IVF was 3.2 [95% confidence interval (CI), 1.4-7.3] and for children born before 2002, 5.2 [95% CI, 2.3-11.9], compared with children in Stockholm County 1992-2001.
  
  
  CONCLUSIONS
  LCH was overrepresented in children born after IVF prior to 2002. Affected children did not have milder disease forms. These findings may be valuable to understand LCH aetiology. Additional studies on a putative correlation between IVF and LCH in the offspring are encouraged.
authors: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. selma.olsson-akefeldt@karolinska.se
authors: Selma O
authors: SO
authors: Akefeldt
authors: Orvar
authors: O
authors: Finnström
authors: Désirée
authors: D
authors: Gavhed
authors: Jan-Inge
authors: JI
authors: Henter
mesh_terms: D002675:Child, Preschool; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012042:Registries; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology