title: The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey.
abstract: We modified an objective behavioral test, namely the food reaching test (FRT), for quantitative assessment of motor performance improved by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in the Parkinsonian monkeys. The symptomatic features and their severity in 3 monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were evaluated with a subjective monkey Parkinson's disease rating scale (PDRS). We then performed STN-DBS with the minimum current intensity that stopped the tremor. The time required for the monkeys to pick up all 5 pieces of potato (FRT time) was measured as a major index to evaluate bradykinesia. The success rate was adopted as another index for assessing overall motor impairments. Although both FRT time and PDRS score were similarly improved by STN-DBS, change of FRT time appeared more sensitive than that of PDRS scores. FRT is an easily trained behavioral test with high objectivity and sensitivity that can be applied for assessing motor performance in MPTP-treated monkeys during experiments in a restrained condition such as functional imaging of the brain.
authors: Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.
authors: Tetsuya
authors: T
authors: Asakawa
authors: Kenji
authors: K
authors: Sugiyama
authors: Souichi
authors: S
authors: Akamine
authors: Chihiro
authors: C
authors: Yokoyama
authors: Miho
authors: M
authors: Shukuri
authors: Hiroshi
authors: H
authors: Mizuma
authors: Hideo
authors: H
authors: Tsukada
authors: Hirotaka
authors: H
authors: Onoe
authors: Hiroki
authors: H
authors: Namba
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D003042:Cocaine / Q000031:analogs & derivatives; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D046690:Deep Brain Stimulation; D004295:Dihydroxyphenylalanine; D004298:Dopamine / Q000378:metabolism; D005247:Feeding Behavior / Q000502:physiology*; D018476:Hypokinesia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D020267:MPTP Poisoning / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016037:Single-Blind Method; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013997:Time Factors; D016896:Treatment Outcome; D014202:Tremor / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy
chemical_list: D002250:Carbon Radioisotopes; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D004295:Dihydroxyphenylalanine; D003042:Cocaine; D004298:Dopamine