title: Does hypoxia-reperfusion injury occur in osteoarthritis of the temporomandibular joint?
abstract: OBJECTIVE
  To determine the available evidence in the literature for whether hypoxia-reperfusion injury plays a role in the pathogenesis of joint diseases in general and of osteoarthritis (OA) of the temporomandibular joint (TMJ) in particular.
  
  
  METHODS
  The electronic databases CENTRAL, PubMed, and EMBASE were systematically searched. The search strategy combined thesaurus terms "reperfusion injury" and "joints" and excluded "tourniquet," which possibly induces iatrogenic reperfusion injury. Inclusion and exclusion criteria were applied, data were extracted, and quality was assessed.
  
  
  RESULTS
  Four studies could be included, investigating four different aspects of the hypoxia-reperfusion mechanism in joints. All studies investigated several arthritides in the knee or shoulder joint and were observational studies, except for one section of one of the studies, which was a randomized controlled trial. These studies do not provide any evidence to support or reject the hypothesis that hypoxia reperfusion occurs in TMJ OA. Positive but weak evidence is provided to support the hypothesis that hypoxia-reperfusion injury occurs in OA of the knee joint. Furthermore, some results of the included studies suggest differences between OA and other types of arthritis in relation to the hypoxia-reperfusion mechanism.
  
  
  CONCLUSIONS
  There is no evidence to support or reject the hypothesis that hypoxia reperfusion occurs in TMJ OA, and limited evidence is provided to support that hypoxia-reperfusion injury occurs in OA of the knee joint. Since the studies suggest differences between OA and other types of arthritis in relation to hypoxia-reperfusion mechanisms, further research in this field needs to distinguish OA from other types of arthritis.
authors: Department of Oral and Maxillofacial Surgery, University of Groningen, Groningen, The Netherlands. l.m.vos@umcg.nl
authors: Lukas M
authors: LM
authors: Vos
authors: James J R Huddleston
authors: JJ
authors: Slater
authors: Martha K
authors: MK
authors: Leijsma
authors: Boudewijn
authors: B
authors: Stegenga
mesh_terms: D006801:Humans; D017746:Joint Capsule / Q000098:blood supply; D010003:Osteoarthritis / Q000503:physiopathology*; D020370:Osteoarthritis, Knee / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012039:Regional Blood Flow; D015427:Reperfusion Injury; D013705:Temporomandibular Joint Disorders / Q000503:physiopathology*
chemical_list: D017382:Reactive Oxygen Species