title: Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives.
abstract: A new series of fluorinated pyrazoles, 4a-e, were synthesized in good to excellent overall yields (65-82%) from the corresponding chalcones, 3a-e, by ultrasonic irradiation. The newly synthesized compounds were characterized and screened for their in vitro anti-bacterial, anti-fungal, and anti-tubercular activities against Mycobacterium tuberculosis H(37)Rv.
authors: Department of Chemistry, SSGM College, Kopargaon, Dist-Ahmednagar (MH) 423601, India.
authors: Sharad N
authors: SN
authors: Shelke
authors: Ganesh R
authors: GR
authors: Mhaske
authors: Vasco D B
authors: VD
authors: Bonifácio
authors: Manoj B
authors: MB
authors: Gawande
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D055772:Green Chemistry Technology; D054879:Halogenation; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009181:Mycoses / Q000188:drug therapy; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D011720:Pyrazoles