title: Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia.
abstract: A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model.
authors: Omeros Corp., 1420 Fifth Ave, Suite 2600, Seattle, WA 98101, USA.
authors: Neil S
authors: NS
authors: Cutshall
authors: Rene
authors: R
authors: Onrust
authors: Alex
authors: A
authors: Rohde
authors: Sasha
authors: S
authors: Gragerov
authors: Lauren
authors: L
authors: Hamilton
authors: Kevin
authors: K
authors: Harbol
authors: Hui-Rong
authors: HR
authors: Shen
authors: Shawn
authors: S
authors: McKee
authors: Charles
authors: C
authors: Zuta
authors: Galina
authors: G
authors: Gragerova
authors: Vince
authors: V
authors: Florio
authors: Thomas N
authors: TN
authors: Wheeler
authors: Jennifer L
authors: JL
authors: Gage
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D006835:Hydrazones / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy* / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D006835:Hydrazones; D010726:Phosphodiesterase Inhibitors; C492284:Pde10a protein, mouse; D010727:Phosphoric Diester Hydrolases