title: Effects of serum uric acid levels on coronary collateral circulation in patients with non-ST elevation acute coronary syndrome.
abstract: OBJECTIVE
  The strong relationship between high level of serum uric acid (UA) and cardiovascular disease has been shown in many studies. In this study, we investigated whether serum UA levels affect coronary collateral circulation (CCC) in patients with non-ST elevation acute coronary syndrome.
  
  
  METHODS
  The study population included 175 patients with non-ST elevation acute coronary syndrome. On the first day of admission to the hospital, blood samples were taken and UA levels were analyzed for all patients. Coronary angiography was performed on patients within 24-72 h. Rentrop collateral classification was performed. Patients were divided into two groups on the basis of UA levels: group I consisted of 102 patients (90 male, 12 female) with normal UA levels and group II consisted of 73 patients (59 male, 14 female) with elevated UA levels.
  
  
  RESULTS
  Group 2 had a significantly higher rate of poorly developed CCC and a lower rate of well-developed CCC compared with group 1 (P=0.003 and 0.001, respectively). Patients with poor CCC had significantly higher serum UA levels compared with patients with well-developed CCC (6.5±1.1 vs. 5.5±1.7 mg/dl, P=0.028). Linear regression analyses showed that poor CCC development was significantly associated with serum UA levels (coefficient=0.22, P=0.005).
  
  
  CONCLUSIONS
  Serum UA level on admission is associated with poor CCC development and may be a useful biomarker for stratification of risk in patients with non-ST elevation acute coronary syndrome.
authors: Department of Cardiology, Ankara Diskapi Training and Research Hospital, Ankara, Turkey.
authors: Haci Ahmet
authors: HA
authors: Kasapkara
authors: Ramazan
authors: R
authors: Topsakal
authors: Mikail
authors: M
authors: Yarlioglues
authors: Gulsum
authors: G
authors: Yarlioglues
authors: Orhan
authors: O
authors: Dogdu
authors: Idris
authors: I
authors: Ardic
authors: Mahmut
authors: M
authors: Akpek
authors: Mehmet Gungor
authors: MG
authors: Kaya
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid