title: Concurrent improvement in biocompatibility and bioinertness of diamond-like carbon films with nitrogen doping.
abstract: The surfaces of implantable biomaterials improving biocompatibility and bioinertness are critical for new application of bioimplantable devices. Diamond-like carbon (DLC) film is a promising biomaterial with use for coating bioimplantable devices because of its good biocompatibility, bioinertness, and mechanical properties. In this study, concurrent improvement in biocompatibility and bioinertness of DLC films has been achieved using N-incorporation technique. The N doping degree was found to play an important role in affecting the biocompatibility and bioinertness of N-doped DLC films. The results indicated that the N-doped DLC films deposited at N(2) concentration of 5% could help to create suitable condition of surface/structure/adhesion combination of DLC films in the both affinity of the L929 mouse fibroblasts and electrochemical inertness in the Hank's balanced salt solutions (simulating human body fluids). N doping supports the attachment and proliferation of cells and prevents the permeation of electrolyte solutions, thereby simultaneity improved the biocompatibility and bioinertness of DLC films. This finding is useful for the fabrication and encapsulation of in vivo devices without induced immune response in the human body.
authors: Department of Mechanical Engineering, Institute of Manufacturing Technology, National Taipei University of Technology, Taipei, Taiwan.
authors: Wen-Hsiang
authors: WH
authors: Liao
authors: Chii-Ruey
authors: CR
authors: Lin
authors: Da-Hua
authors: DH
authors: Wei
authors: You-Ruey
authors: YR
authors: Shen
authors: Yi-Chieh
authors: YC
authors: Li
authors: Jen-Ai
authors: JA
authors: Lee
authors: Chia-Yao
authors: CY
authors: Liang
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D002470:Cell Survival; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D018130:Diamond / Q000737:chemistry / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology*; D008422:Materials Testing; D051379:Mice; D009584:Nitrogen / Q000737:chemistry* / Q000378:metabolism; D017155:Wettability
chemical_list: D020099:Coated Materials, Biocompatible; D002244:Carbon; D018130:Diamond; D009584:Nitrogen