title: Association between manganese superoxide dismutase gene polymorphism and breast cancer risk: a meta-analysis of 17,842 subjects.
abstract: The aim of this meta-analysis was to explore the association between the manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk, and to investigate the interaction of this gene polymorphism with known risk factors for breast cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) for breast cancer risk associated with co-dominant models [valine/alanine (Val/Ala) vs. Val/Val, Ala/Ala vs. Val/Val], a dominant model (Val/Ala + Ala/Ala vs. Val/Val) and a recessive model (Ala/Ala vs. Val/Ala + Val/Val) were statistically estimated. This meta‑analysis included 8,102 breast cancer cases and 9,740 controls from 14 published case-control studies. The data revealed no significant association between the MnSOD polymorphism and the risk of developing breast cancer. However, upon subgroup analyses, the risk was significantly increased in premenopausal women with the dominant model of the MnSOD gene polymorphism (OR, 1.15; 95% CI, 1.01-1.31). Statistically significant increased risks were also identified in women with the MnSOD genotypes containing the Ala allele who had a tobacco smoking history (OR, 1.17; 95% CI, 1.02-1.34), a higher body mass index (OR, 1.26; 95% CI, 1.02-1.56) or who used oral contraceptives (OR, 1.98; 95% CI, 1.34-2.93). By contrast, there was no significant association between breast cancer risk and alcohol consumption and ethnicity. This meta‑analysis demonstrated no statistically significant association between the MnSOD gene polymorphism and breast cancer susceptibility, except in premenopausal women with certain unhealthy lifestyle habbits.
authors: Department of Endocrinology (Section I), Tangshan Workers Hospital, Tangshan, PR China.
authors: Geling
authors: G
authors: Liu
authors: Guogui
authors: G
authors: Sun
authors: Yadi
authors: Y
authors: Wang
authors: Dan
authors: D
authors: Wang
authors: Wanning
authors: W
authors: Hu
authors: Jun
authors: J
authors: Zhang
mesh_terms: D000428:Alcohol Drinking; D000483:Alleles; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use; D005260:Female; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017697:Premenopause; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism
chemical_list: D003278:Contraceptives, Oral, Hormonal; D013482:Superoxide Dismutase