title: Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis.
abstract: Recognizing the invasive potential of the dermatophytes and understanding the mechanisms involved in this process will help with disease diagnosis and with developing an appropriate treatment plan. In this report, we present the histopathological, microbiological and immunological features of a model of invasive dermatophytosis that is induced by subcutaneous infection of Trichophyton mentagrophytes in healthy adult Swiss mice. Using this model, we observed that the fungus rapidly spreads to the popliteal lymph nodes, spleen, liver and kidneys. Similar to the human disease, the lymph nodes were the most severely affected sites. The fungal infection evoked acute inflammation followed by a granulomatous reaction in the mice, which is similar to what is observed in patients. The mice were able to mount a Th1-polarized immune response and displayed IL-10-mediated immune regulation. We believe that the model described here will provide valuable information regarding the dermatophyte-host relationship and will yield new perspective for a better understanding of the immunological and pathological aspects of invasive dermatophytosis.
authors: Faculdade de Ciências, Univ Estadual Paulista, Departamento de Ciências Biológicas, Laboratório de Imunopatologia Experimental, Av. Eng. Luiz Edmundo C. Coube 14-01, Bauru, SP, Brazil.
authors: James
authors: J
authors: Venturini
authors: Anuska Marcelino
authors: AM
authors: Alvares
authors: Marcela Rodrigues de
authors: MR
authors: Camargo
authors: Camila Martins
authors: CM
authors: Marchetti
authors: Thais Fernanda de Campos
authors: TF
authors: Fraga-Silva
authors: Ana Carolina
authors: AC
authors: Luchini
authors: Maria Sueli Parreira de
authors: MS
authors: Arruda
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D056724:Immunity, Humoral / Q000276:immunology; D007279:Injections, Subcutaneous; D016753:Interleukin-10 / Q000276:immunology* / Q000378:metabolism; D007668:Kidney / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000276:immunology / Q000382:microbiology; D008198:Lymph Nodes / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D012867:Skin / Q000276:immunology / Q000382:microbiology; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D018417:Th1 Cells / Q000276:immunology; D013997:Time Factors; D014005:Tinea / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D014249:Trichophyton / Q000254:growth & development / Q000276:immunology* / Q000502:physiology
chemical_list: D000946:Antigens, Fungal; D016207:Cytokines; D016753:Interleukin-10