title: Desmoplastic reaction in biopsy specimens of early colorectal cancer: a Japanese prospective multicenter study.
abstract: We previously reported that detection of desmoplastic reaction (DR) in pretreatment biopsy specimens was useful for predicting the depth of submucosal invasion (SM depth) in nonpedunculated early colorectal cancers (ECRCs) in a retrospective study. Here, we performed a prospective multicenter study for verification of our previous findings. Subjects were diagnosed with ECRC by endoscopy, and with adenocarcinoma from the biopsy specimens. Eleven institutions affiliated with the Japanese Society for Cancer of the Colon and Rectum participated in this collaborative study. A total of 112 patients with ECRC were enrolled. For nonpedunculated ECRCs, presence of DR was significantly correlated with SM depth. The sensitivity and specificity of detection of DR for prediction of pSM2 (tumor invasion ≥1000 µm) in nonpedunculated ECRCs were 68.6% and 92.0%, respectively. Evaluation of DR in pretreatment biopsy specimens may be useful for the clinicopathological diagnosis of colorectal carcinoma with massive invasion into the submucosal layer.
authors: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
authors: Ryusuke
authors: R
authors: Kimura
authors: Takahiro
authors: T
authors: Fujimori
authors: Kazuhito
authors: K
authors: Ichikawa
authors: Yoichi
authors: Y
authors: Ajioka
authors: Hideki
authors: H
authors: Ueno
authors: Yasuo
authors: Y
authors: Ohkura
authors: Hiroshi
authors: H
authors: Kashida
authors: Kazutomo
authors: K
authors: Togashi
authors: Takashi
authors: T
authors: Yao
authors: Ryo
authors: R
authors: Wada
authors: Toshiaki
authors: T
authors: Watanabe
authors: Atsushi
authors: A
authors: Ochiai
authors: Tamotsu
authors: T
authors: Sugai
authors: Kenichi
authors: K
authors: Sugihara
authors: Yoshinori
authors: Y
authors: Igarashi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary; D000368:Aged; D001706:Biopsy; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D042241:Early Diagnosis; D005260:Female; D024022:Fibrillar Collagens; D005773:Gastroscopy; D006801:Humans; D007420:Intestine, Large / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D058628:Myofibroblasts / Q000473:pathology; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011446:Prospective Studies
chemical_list: D024022:Fibrillar Collagens