title: Fine neurite patterns from photocrosslinking of cell-repellent benzophenone copolymer.
abstract: We have synthesized photocrosslinkable benzophenone copolymer, Poly(St-co-MBz), and fabricated cell-repellent patterns of Poly(St-co-MBz) on covalently bound poly-D-lysine (PDL) layer via the photocrosslinking. We have successfully obtained fine grid line pattern with line width of 3 μm and fine neurite, presumably axon, patterns with excellent pattern fidelity. We found that benzophenone unit can be crosslinked under the exposure of UV (with the intensity of ∼77 mW/cm² at 280 nm and ∼60 mW/cm² at 365 nm) without photo-oxidative damage to PDL, poly-L-lysine, and polyethyleneimine.
authors: IT Convergence Technology Research Lab., ETRI, Daejeon 305-700, Republic of Korea.
authors: Nam Seob
authors: NS
authors: Baek
authors: Yong Hee
authors: YH
authors: Kim
authors: Young Hwan
authors: YH
authors: Han
authors: Andreas
authors: A
authors: Offenhäusser
authors: Myung-Ae
authors: MA
authors: Chung
authors: Sang-Don
authors: SD
authors: Jung
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000494:pharmacology; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D004622:Embryo, Mammalian; D016501:Neurites / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D017319:Photosensitizing Agents; D011107:Polylysine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013050:Spectrometry, Fluorescence; D014404:Tubulin / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D001577:Benzophenones; D017319:Photosensitizing Agents; D011108:Polymers; D014404:Tubulin; D011107:Polylysine; C047723:benzophenone