title: Laurene-type sesquiterpenes from the Red Sea red alga Laurencia obtusa as potential antitumor-antimicrobial agents.
abstract: Three new laurene-type sesquiterpenes, 12-hydroxy isolaurene (1), 8,11-dihydro-12-hydroxy isolaurene (2) and isolauraldehyde (3) were isolated from the organic extract of the red alga Laurencia obtusa. The chemical structures of isolates were determined by interpretation of their spectral data 1D and 2D NMR, UV, IR and MS. The newly isolated compounds were tested for their antimicrobial and antitumor activities. Compounds (1-3) exhibited potent activity against the gram-positive Bacillus subtilis and Staphylococcus aureus, where 3 proved to be the most active (MIC 35 and 27 μg/mL, respectively). Moreover, compound 3 exhibited a significant activity against Candida albicans (MIC of 70 μg/mL) and revealed to have very promising activity in an in vitro model of Ehrlich ascites Carcinoma.
authors: Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO. Box 80207, Jeddah 21589, Saudi Arabia. walied1737@yahoo.com
authors: Walied M
authors: WM
authors: Alarif
authors: Sultan S
authors: SS
authors: Al-Lihaibi
authors: Seif-Eldin N
authors: SE
authors: Ayyad
authors: Mohamed H
authors: MH
authors: Abdel-Rhman
authors: Farid A
authors: FA
authors: Badria
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D044722:Laurencia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D012717:Sesquiterpenes