title: Mitochondria as sensors and regulators of calcium signalling.
abstract: During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention.
authors: Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G. Colombo 3, 35131 Padua, Italy. rosario.rizzuto@unipd.it
authors: Rosario
authors: R
authors: Rizzuto
authors: Diego
authors: D
authors: De Stefani
authors: Anna
authors: A
authors: Raffaello
authors: Cristina
authors: C
authors: Mammucari
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D003600:Cytosol / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D015220:Calcium Channels; D002118:Calcium