title: Laquinimod modulates B cells and their regulatory effects on T cells in multiple sclerosis.
abstract: Laquinimod is an orally administered drug under development for the treatment of Multiple Sclerosis (MS), lacking a fully elucidated mode of action. We assessed the immunomodulatory effects of laquinimod in vitro on human B cells from healthy or MS patients, cultured alone or with CD4(+) T cells. Laquinimod modulated B cell markers, mainly by increasing the regulatory ones CD25, IL10 and CD86, and decreased IL4, while increasing IL10 and TGFβ in both B and T cells, in a B cell-mediated manner. These findings shed additional light on the mechanisms underlying the effects of laquinimod in MS and potentially other immune-mediated diseases.
authors: Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel.
authors: Elias
authors: E
authors: Toubi
authors: Shahar
authors: S
authors: Nussbaum
authors: Elsebeth
authors: E
authors: Staun-Ram
authors: Ayelet
authors: A
authors: Snir
authors: Doron
authors: D
authors: Melamed
authors: Liat
authors: L
authors: Hayardeny
authors: Ariel
authors: A
authors: Miller
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects*; D051940:B7-2 Antigen / Q000096:biosynthesis; D002478:Cells, Cultured; D018920:Coculture Techniques; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000096:biosynthesis; D053645:Interleukin-2 Receptor alpha Subunit / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D015363:Quinolones / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D055815:Young Adult
chemical_list: D051940:B7-2 Antigen; C508609:IL10 protein, human; C508017:IL2RA protein, human; C508598:IL4 protein, human; D007155:Immunologic Factors; D053645:Interleukin-2 Receptor alpha Subunit; D015363:Quinolones; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D015847:Interleukin-4; C476223:laquinimod