title: An ent-kaurane-type diterpene in Croton antisyphiliticus mart.
abstract: Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay.
authors: Department of Biotechnology, University of Ribeirão Preto (UNAERP), Av. Costábile Romano, 2201, CEP 14096-900, Ribeirão Preto, SP, Brazil.
authors: Sarazete
authors: S
authors: Pereira
authors: Silvia
authors: S
authors: Taleb-Contini
authors: Juliana
authors: J
authors: Coppede
authors: Paulo
authors: P
authors: Pereira
authors: Bianca
authors: B
authors: Bertoni
authors: Suzelei
authors: S
authors: França
authors: Ana Maria
authors: AM
authors: Pereira
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002725:Chloroform / Q000737:chemistry; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D052616:Solid Phase Extraction; D012997:Solvents / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts; D012997:Solvents; C051436:kaurenoic acid; D002725:Chloroform