title: Absence of KIAA1549-BRAF fusion in rosette-forming glioneuronal tumors of the fourth ventricle (RGNT).
abstract: Rosette-forming glioneuronal tumors (RGNT) of the fourth ventricle are rare mixed glioneuronal tumors included in the revised WHO classification of central nervous system tumors, showing partial histological similarities to pilocytic astrocytomas. To evaluate potential similarities at the molecular level between these tumors, we analysed a series of 10 RGNT for the presence of KIAA1549-BRAF fusions using interphase fluorescence in situ hybridisation. However, we found no cases showing KIAA1549-BRAF gene fusion or BRAF                         (V600E) mutation. Our data support the hypothesis that RGNT may represent a distinct entity among the glioneuronal tumors of the central nervous system, with molecular features different from pilocytic astrocytomas.
authors: Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. mgessimd@yahoo.com
authors: Marco
authors: M
authors: Gessi
authors: Sally R
authors: SR
authors: Lambert
authors: Libero
authors: L
authors: Lauriola
authors: Andreas
authors: A
authors: Waha
authors: V Peter
authors: VP
authors: Collins
authors: Torsten
authors: T
authors: Pietsch
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002551:Cerebral Ventricle Neoplasms / Q000235:genetics; D002648:Child; D005260:Female; D020546:Fourth Ventricle / Q000473:pathology*; D018303:Ganglioglioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D050596:Oncogene Fusion / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012397:Rosette Formation
chemical_list: D015514:Oncogene Proteins, Fusion; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf