title: Impact of the AT(2) receptor agonist C21 on blood pressure and beyond.
abstract: It is now widely accepted that the angiotensin AT(2) receptor (AT(2)R) plays an important protective role during pathophysiologic conditions, acting as a repair system. The development of the first selective nonpeptide AT(2)R agonist C21 accelerated our understanding of AT(2)R-mediated protective signaling and actions. This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension-induced vascular and other end organ damages via anti-apoptotic, anti-fibrotic and anti-inflammatory actions. In particular, a strong body of evidence started to emerge around its anti-inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.
authors: Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands. s.foulquier@maastrichtuniversity.nl
authors: Sébastien
authors: S
authors: Foulquier
authors: U Muscha
authors: UM
authors: Steckelings
authors: Thomas
authors: T
authors: Unger
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D006973:Hypertension / Q000188:drug therapy*; D044139:Receptor, Angiotensin, Type 2 / Q000819:agonists*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013449:Sulfonamides / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D057911:Angiotensin Receptor Antagonists; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; C494557:N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide; D044139:Receptor, Angiotensin, Type 2; D013449:Sulfonamides; D013876:Thiophenes; D014665:Vasodilator Agents