title: Intravenous hypertonic saline to reduce intraocular pressure.
abstract: OBJECTIVE
  To quantitate the effect of intravenous hypertonic saline (IVHTS) injection on elevated intraocular pressure (IOP).
  
  
  METHODS
  Nineteen patients (median age, 65 years; range, 41-84 years) with glaucoma and an IOP 30 mmHg or higher were recruited. A bolus of IVHTS (sodium chloride concentration 23.4%) was injected in an antecubital vein over 10-20 seconds. The IOP and systolic and diastolic blood pressure (BP) were measured frequently for 2 hr. The dosage was 0.5 mmol/kg sodium in 11 patients (Group 1) and 1.0 mmol/kg in eight patients (Group 2).
  
  
  RESULTS
  In both groups, a median absolute IOP reduction of 7 mmHg was achieved in 5 min. The maximum median reduction was 7 mmHg (range, 4-16) and 9 mmHg (range, 3-14) at 5 and 16 min after IVHTS in Group 1 and 2, respectively, at which point the median IOP had reduced from 38 and 35 mmHg to 31 and 27 mmHg (p < 0.001), respectively. In both groups, the IOP remained 7 mmHg reduced 2 hr after IVHTS. Systolic BP increased a median of 14.5 mmHg at 3 min and was comparable with baseline after 6 min.
  
  
  CONCLUSIONS
  Intravenous hypertonic saline solution reduces IOP moderately within minutes for up to 2 hr.
authors: Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, FinlandDepartment of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland.
authors: Mika
authors: M
authors: Harju
authors: Tero
authors: T
authors: Kivelä
authors: Nina
authors: N
authors: Lindbohm
authors: Riku
authors: R
authors: Koivusalo
authors: Markku
authors: M
authors: Paloheimo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012462:Saline Solution, Hypertonic / Q000009:adverse effects / Q000627:therapeutic use*; D014065:Tonometry, Ocular
chemical_list: D012462:Saline Solution, Hypertonic