title: Assessment of tamsulosin as a potential male contraceptive in healthy volunteers.
abstract: OBJECTIVE
  To investigate the efficacy and safety of tamsulosin, an α(1A)-adrenoceptor antagonist, as a potential male contraceptive.
  
  
  METHODS
  Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.
  
  
  RESULTS
  Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.
  
  
  CONCLUSIONS
  When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.
authors: Department of Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong Province, China.
authors: Jin
authors: J
authors: Wang
authors: Yong
authors: Y
authors: Zhao
authors: Shao-bo
authors: SB
authors: Jiang
authors: Qing-hua
authors: QH
authors: Xia
authors: Chun-xiao
authors: CX
authors: Wei
authors: Mu-wen
authors: MW
authors: Wang
authors: Peng
authors: P
authors: Sun
authors: Xun-bo
authors: XB
authors: Jin
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000328:Adult; D003272:Contraceptive Agents, Male; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D013449:Sulfonamides; D000077409:Tamsulosin; D055815:Young Adult
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D003272:Contraceptive Agents, Male; D013449:Sulfonamides; D000077409:Tamsulosin