title: Mean platelet volume/platelet count ratio in hepatocellular carcinoma.
abstract: Mean platelet volume (MPV) has been actively investigated in liver disease such as steatosis, cirrhosis and hepatitis. Recently, MPV/platelet count (PC) ratio has been proposed as a predictor of long-term mortality after myocardial infarction. As PC is known to be decreased in various liver diseases such as cirrhosis, hepatosplenomegaly and malignancy, we planned to evaluate MPV/PC ratio in patients with hepatocellular carcinoma (HCC) in this study. Mean of MPV levels showed significant difference, which were 8.69 fl (range 6.7-12.2 fl) in patients group and 8.02 fl in control group (range 6.7-11.0 fl). In receiver operating characteristic (ROC) curve analysis, the MPV/PC ratio (fl/(10(9)/l)) presented 74.5% of sensitivity and 96.5% of specificity at the criterion > 0.0491 (area under the curve (AUC) = 0.884), while MPV alone showed 57.4% of sensitivity and 81.4% of specificity at the criterion > 8.4 fl. Further studies should evaluate underlying pathogenic mechanisms of MPV/PC ratio difference and various possibilities of this ratio as an indicator of presence of a tumor in HCC.
authors: Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors: Sun Young
authors: SY
authors: Cho
authors: John Jeongseok
authors: JJ
authors: Yang
authors: Eunkyoung
authors: E
authors: You
authors: Byung-Ho
authors: BH
authors: Kim
authors: Jaejun
authors: J
authors: Shim
authors: Hee Joo
authors: HJ
authors: Lee
authors: Woo-In
authors: WI
authors: Lee
authors: Jin-Tae
authors: JT
authors: Suh
authors: Tae Sung
authors: TS
authors: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012372:ROC Curve