title: Permission to enter cell by shape: nanodisk vs nanosphere.
abstract: Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.
authors: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors: Yi
authors: Y
authors: Zhang
authors: Samuel
authors: S
authors: Tekobo
authors: Ying
authors: Y
authors: Tu
authors: Qunfang
authors: Q
authors: Zhou
authors: Xinlong
authors: X
authors: Jin
authors: Sergey A
authors: SA
authors: Dergunov
authors: Eugene
authors: E
authors: Pinkhassik
authors: Bing
authors: B
authors: Yan
mesh_terms: D017209:Apoptosis; D002453:Cell Cycle; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D011992:Endosomes / Q000378:metabolism; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D008027:Light; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D017382:Reactive Oxygen Species; D012542:Scattering, Radiation; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods
chemical_list: D017382:Reactive Oxygen Species