title: Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent.
abstract: This work presents a highly efficient, broad spectrum and self-delivery anticancer agent, which is the hyperbranched polydiselenide (HPSe) consisting of alternative hydrophobic diselenide groups and hydrophilic phosphate segments in the backbone framework. The data of systematic evaluations demonstrate that HPSe is very potent to inhibit the proliferation of many forms of cancer cell. The dose of HPSe required for growth inhibition of 50% (IC(50)) in all of the tested cancer cell lines is within the concentration range between 1 and 2.5 μg mL(-1) with the incubation time of 72 h. Furthermore, the amphiphilic HPSe can self-assembly into nanomicelles with an average diameter of 50 nm and spontaneously enter into tumor cells by the enhanced permeability and retention (EPR) effect. Besides, other hydrophobic anticancer drugs such as doxorubicin (DOX) can be encapsulated into HPSe micelles for combining therapy.
authors: School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, China.
authors: Jinyao
authors: J
authors: Liu
authors: Yan
authors: Y
authors: Pang
authors: Jun
authors: J
authors: Chen
authors: Ping
authors: P
authors: Huang
authors: Wei
authors: W
authors: Huang
authors: Xinyuan
authors: X
authors: Zhu
authors: Deyue
authors: D
authors: Yan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D053148:Caspase 3 / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D005453:Fluorescence; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008823:Micelles; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D016566:Organoselenium Compounds; D004317:Doxorubicin; D053148:Caspase 3; D005978:Glutathione