title: From pluripotent stem cells to multifunctional cordocytic phenotypes in the human brain: an ultrastructural study.
abstract: Light microscopy and transmission electron microscopy were used to investigate surgical cases in a variety of pathological conditions (thromboses, tumors, cerebrovascular malformations, Moyamoya disease) to identify and characterize different phenotypes belonging to a new interstitial cell recently described ultrastructurally in the brain and here named "cordocyte." Also, this work is an attempt to identify and characterize precursor/stem cells for cordocytic lineage in the perivascular areas, within perivascular nerves and pia mater (now considered a cordocytic-vascular tissue). Unexpected relationships and functions emerge from observations concerning these phenotypes, almost ubiquitous, but not yet fully studied in the brain.
authors: Department of Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania. viorelpais@hotmail.com
authors: Viorel
authors: V
authors: Pais
authors: Leon
authors: L
authors: Danaila
authors: Emil
authors: E
authors: Pais
mesh_terms: D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000648:ultrastructure; D001921:Brain / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010641:Phenotype; D010841:Pia Mater / Q000098:blood supply / Q000648:ultrastructure*; D039904:Pluripotent Stem Cells / Q000648:ultrastructure*; D055815:Young Adult