title: Advances in nanotechnology-based delivery systems for curcumin.
abstract: Curcumin (CUR), a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of CUR in inflammatory disorders, cardiovascular disease, cancer, Alzheimer's disease and neurological disorders have been shown. However, the clinical application of CUR is severely limited by its main drawbacks such as instability, low solubility, poor bioavailability and rapid metabolism. Multifarious nanotechnology-based delivery approaches have been used to enhance the oral bioavailability, biological activity or tissue-targeting ability of CUR. This article reviews potential novel drug delivery systems for CUR including liposomes, polymeric nanoparticles, solid lipid nanoparticles, micelles, nanogels, nanosuspensions, nanoemulsions, complexes and dendrimer/dimer, which provide promising results for CUR to improve its biological activities.
authors: Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
authors: Min
authors: M
authors: Sun
authors: Xun
authors: X
authors: Su
authors: Buyun
authors: B
authors: Ding
authors: Xiuli
authors: X
authors: He
authors: Xiuju
authors: X
authors: Liu
authors: Aihua
authors: A
authors: Yu
authors: Hongxiang
authors: H
authors: Lou
authors: Guangxi
authors: G
authors: Zhai
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D003474:Curcumin