title: Potential role of prokineticin 2 in experimental varicocele-induced rat testes.
abstract: OBJECTIVE
  To determine the possible role of prokineticin 2 in varicocele by inducing varicoceles in adult rats.
  
  
  METHODS
  Forty male Sprague-Dawley rats were used for sham operation (n = 10) and varicocele (n = 30) groups. Experimental varicocele was induced by partial ligation of the left renal vein in the varicocele, whereas the sham operation group only received a sham induction of varicocele. Left testes were harvested for real-time quantitative polymerase chair readtion analysis 2, 4, and 8 weeks after the induction of varicocele.
  
  
  RESULTS
  The expression of prokineticin 2 mRNA in 8-week varicocele-induced rats was significantly higher (P < .05) than that in the sham operation group.
  
  
  CONCLUSIONS
  The present study suggests that prokineticin 2 expression is increased by varicocele induction and it may have a role in varicocele-induced infertility.
authors: Institute of Family Planning Research, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors: Li-Hui
authors: LH
authors: Tu
authors: Li-Li
authors: LL
authors: Yu
authors: Cheng-Liang
authors: CL
authors: Xiong
authors: Hui-Ping
authors: HP
authors: Zhang
mesh_terms: D000818:Animals; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism* / Q000473:pathology*; D014646:Varicocele / Q000378:metabolism*
chemical_list: D005768:Gastrointestinal Hormones; D009479:Neuropeptides; D012333:RNA, Messenger; C513686:prokineticin 2, rat