title: Influence of whole-body vibration on biodistribution of the radiopharmaceutical [99mTc]methylene diphosphonate in Wistar rats.
abstract: OBJECTIVE
  The radionuclide bone scan is the basis of skeletal nuclear medicine imaging. Bone scintigraphy is a highly sensitive method for indicating disease in bone. Mechanical stimulation in the manner of whole-body vibration (WBV) appears beneficial to the maintenance and/or enhancement of skeletal mass in individuals. The aim of this work was to evaluate the effect of WBV on the biodistribution of the radiopharmaceutical [99mTc]methylene diphosphonate (99mTc-MDP) in Wistar rats.
  
  
  METHODS
  In the biodistribution analysis, animals were anesthetized with sodium thiopental, the radiopharmaceutical (99m)Tc-MDP was administered via ocular plexus and after 10 min the animals were submitted to vibration of 20 Hz (1 min) in an oscillatory platform. Following, the animals were sacrificed, the organs were isolated, the radioactivity determined in a well counter, and the percentages of radioactivity per gram (%ATI/g) in the organs were calculated. An unpaired t-test following Welch test (p < 0.05) was done for statistical analysis of the results.
  
  
  RESULTS
  The biodistribution was significantly (p < 0.05) decreased in kidney, bone, lung, stomach, prostate and bowel.
  
  
  CONCLUSIONS
  The analysis of the results indicates that the vibration could produce metabolic alterations with influence in the uptake of the radiopharmaceutical 99mTc-MDP in bone, stomach, bowel, prostate, kidney and bladder.
authors: Programa de Pós-Graduação em Ciências da Saúde da Universidade Federal do Rio Grande do Norte, Brazil. marciaoliveira.13@terra.com.br
authors: Marcia de Oliveira
authors: Mde O
authors: Pereira
authors: Nelson de Souza
authors: Nde S
authors: Pinto
authors: Milena de O B
authors: Mde O
authors: Monteiro
authors: Sebastião David
authors: SD
authors: Santos-Filho
authors: Fernanda Santos
authors: FS
authors: Carmo
authors: Claudia Leite
authors: CL
authors: Diniz
authors: Pedro Jesus
authors: PJ
authors: Marin
authors: Mario
authors: M
authors: Bernardo-Filho
mesh_terms: D000818:Animals; D008297:Male; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014732:Vibration
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate