title: Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.
abstract: The rapid and convenient method for identification of all kinds of G-quadruplex is highly desirable. In the present study, a novel colorimetric indicator for a vast variety of G-quadruplex was designed and synthesized on the basis of thiazole orange and isaindigotone skeleton. Its distinct color change enables label-free visual detection of G-quadruplexes, which is due to the disassembly of dye H-aggregates to monomers. This specific detection of G-quadruplex arises from its end-stacking interaction with G-quartet. On the basis of this universal indicator, a facile approach for large-scale identification of G-quadruplex was developed.
authors: Jin-Wu
authors: JW
authors: Yan
authors: Wen-Jie
authors: WJ
authors: Ye
authors: Shuo-Bin
authors: SB
authors: Chen
authors: Wei-Bin
authors: WB
authors: Wu
authors: Jin-Qiang
authors: JQ
authors: Hou
authors: Tian-Miao
authors: TM
authors: Ou
authors: Jia-Heng
authors: JH
authors: Tan
authors: Ding
authors: D
authors: Li
authors: Lian-Quan
authors: LQ
authors: Gu
authors: Zhi-Shu
authors: ZS
authors: Huang
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D003124:Colorimetry; D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D007202:Indicators and Reagents / Q000737:chemistry; D011799:Quinazolines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D052160:Benzothiazoles; D007202:Indicators and Reagents; D011799:Quinazolines; D011804:Quinolines; C440668:isaindigotone; C051000:thiazole orange