title: Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties.
abstract: Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe  stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.
authors: Ontario Cancer Institute and Techna Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7.
authors: Elizabeth
authors: E
authors: Huynh
authors: Jonathan F
authors: JF
authors: Lovell
authors: Brandon L
authors: BL
authors: Helfield
authors: Mansik
authors: M
authors: Jeon
authors: Chulhong
authors: C
authors: Kim
authors: David E
authors: DE
authors: Goertz
authors: Brian C
authors: BC
authors: Wilson
authors: Gang
authors: G
authors: Zheng
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D005260:Female; D017611:Fluorine Compounds / Q000008:administration & dosage; D005740:Gases / Q000008:administration & dosage; D006801:Humans; D051379:Mice; D045423:Microbubbles; D010743:Phospholipids / Q000737:chemistry; D061088:Photoacoustic Techniques; D011166:Porphyrins / Q000737:chemistry; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D017611:Fluorine Compounds; D005740:Gases; D010743:Phospholipids; D011166:Porphyrins