title: Pd-catalyzed C-H fluorination with nucleophilic fluoride.
abstract: The palladium-catalyzed C-H fluorination of 8-methylquinoline derivatives with nucleophilic fluoride is reported. This transformation involves the use of AgF as the fluoride source in combination with a hypervalent iodine oxidant. Both the scope and mechanism of the reaction are discussed.
authors: University of Michigan, Department of Chemistry, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
authors: Kate B
authors: KB
authors: McMurtrey
authors: Joy M
authors: JM
authors: Racowski
authors: Melanie S
authors: MS
authors: Sanford
mesh_terms: D002384:Catalysis; D005459:Fluorides / Q000737:chemistry; D054879:Halogenation; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D011804:Quinolines; D010165:Palladium; C057609:8-methylquinoline; D005459:Fluorides