title: Briarenolides F and G, new briarane diterpenoids from a Briareum sp. octocoral.
abstract: Two new briarane diterpenoids, briarenolides, F (1) and G (2), were isolated from an octocoral identified as Briareum sp. The structures of briaranes 1 and 2 were established by spectroscopic methods and by comparison of the spectroscopic data with those of known briarane analogues. Briarenolide F was proven to be the first 6-hydroperoxybriarane derivative and this compound displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Pei-Han
authors: PH
authors: Hong
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Yin-Di
authors: YD
authors: Su
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Jui-Hsin
authors: JH
authors: Su
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Yung-Husan
authors: YH
authors: Chen
authors: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors: Tsong-Long
authors: 0000-0002-5780-3977
authors: TL
authors: Hwang
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
authors: Ching-Feng
authors: CF
authors: Weng
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
authors: Chia-Hung
authors: CH
authors: Lee
authors: Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Zhi-Hong
authors: 0000-0003-4411-044X
authors: ZH
authors: Wen
authors: Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Jyh-Horng
authors: JH
authors: Sheu
authors: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors: Nai-Cheng
authors: NC
authors: Lin
authors: Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan.
authors: Yueh-Hsiung
authors: 0000-0001-5935-6755
authors: YH
authors: Kuo
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
authors: Ping-Jyun
authors: 0000-0002-6644-9236
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D004224:Diterpenes; D013481:Superoxides; D010196:Pancreatic Elastase