title: Quantum dot-nucleic acid/aptamer bioconjugate-based fluorimetric biosensors.
abstract: Over the last 10 years, fluorescent semiconductor QD (quantum dot)-biomolecule conjugates have emerged as a powerful new sensing platform showing great potential in a wide range of applications in biosensing, environmental monitoring and disease diagnosis. The present mini-review is a brief account of the recent developments in QD-NA (nucleic acid), particularly NA aptamer, conjugate-based biosensors using the FRET (Förster resonance energy transfer) readout mechanism. It starts with a brief introduction to the NA aptamer and QD-FRET, followed by example approaches to compact QD-DNA conjugates, target readout strategies and sensing performance, and concludes with challenges and outlook for the QD-NA/aptamer bioconjugate sensors.
authors: School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. d.zhou@leeds.ac.uk
authors: Dejian
authors: D
authors: Zhou
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D031541:Fluorescence Resonance Energy Transfer; D005470:Fluorometry; D009696:Nucleic Acids / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D052157:Aptamers, Nucleotide; D009696:Nucleic Acids