title: The contribution of primary and secondary somatosensory cortices to the representation of body parts and body sides: an fMRI adaptation study.
abstract: Although the somatosensory homunculus is a classically used description of the way somatosensory inputs are processed in the brain, the actual contributions of primary (SI) and secondary (SII) somatosensory cortices to the spatial coding of touch remain poorly understood. We studied adaptation of the fMRI BOLD response in the somatosensory cortex by delivering pairs of vibrotactile stimuli to the finger tips of the index and middle fingers. The first stimulus (adaptor) was delivered either to the index or to the middle finger of the right or left hand, and the second stimulus (test) was always administered to the left index finger. The overall BOLD response evoked by the stimulation was primarily contralateral in SI and was more bilateral in SII. However, our fMRI adaptation approach also revealed that both somatosensory cortices were sensitive to ipsilateral as well as to contralateral inputs. SI and SII adapted more after subsequent stimulation of homologous as compared with nonhomologous fingers, showing a distinction between different fingers. Most importantly, for both somatosensory cortices, this finger-specific adaptation occurred irrespective of whether the tactile stimulus was delivered to the same or to different hands. This result implies integration of contralateral and ipsilateral somatosensory inputs in SI as well as in SII. Our findings suggest that SI is more than a simple relay for sensory information and that both SI and SII contribute to the spatial coding of touch by discriminating between body parts (fingers) and by integrating the somatosensory input from the two sides of the body (hands).
authors: University of Trento, Italy. l.tame@reading.ac.uk
authors: Luigi
authors: L
authors: Tamè
authors: Christoph
authors: C
authors: Braun
authors: Angelika
authors: A
authors: Lingnau
authors: Jens
authors: J
authors: Schwarzbach
authors: Gianpaolo
authors: G
authors: Demarchi
authors: Yiwen
authors: Y
authors: Li Hegner
authors: Alessandro
authors: A
authors: Farnè
authors: Francesco
authors: F
authors: Pavani
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology; D003627:Data Interpretation, Statistical; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D005403:Fixation, Ocular; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D010812:Physical Stimulation; D012649:Self Concept; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology; D014732:Vibration
chemical_list: D010100:Oxygen