title: Mechanical and biological performances of new scaffolds made of collagen hydrogels and fibroin microfibers for vascular tissue engineering.
abstract: A microstructured composite material made of collagen hydrogel (matrix) and silk fibroin microfibers (randomly oriented reinforcing fibers) is investigated in order to conjugate the mechanical resistance of fibroin with the suitable biological performance of collagen to design new scaffolds for vascular tissue engineering. Results show that fibroin microfibers and collagen fibrils have suitable interfacial adhesion, and the scaffold exhibits improved mechanical properties if compared with a pure collagen hydrogel. Furthermore, the overall biological performance is improved.
authors: Laboratory of Engineering and Chemistry of Products, School of Chemical Engineering, University of Campinas, UNICAMP, Campinas, Brazil.
authors: Mariana Agostini
authors: MA
authors: de Moraes
authors: Estelle
authors: E
authors: Paternotte
authors: Diego
authors: D
authors: Mantovani
authors: Marisa Masumi
authors: MM
authors: Beppu
mesh_terms: D001808:Blood Vessels; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels; D013718:Tensile Strength; D023822:Tissue Engineering
chemical_list: D020100:Hydrogels; D003094:Collagen; D005349:Fibroins