title: Protective ventilation in experimental acute respiratory distress syndrome after ventilator-induced lung injury: a randomized controlled trial.
abstract: BACKGROUND
  Low tidal volume (V(T)), PEEP, and low plateau pressure (P(PLAT)) are lung protective during acute respiratory distress syndrome (ARDS). This study tested the hypothesis that the aspiration of dead space (ASPIDS) together with computer simulation can help maintain gas exchange at these settings, thus promoting protection of the lungs.
  
  
  METHODS
  ARDS was induced in pigs using surfactant perturbation plus an injurious ventilation strategy. One group then underwent 24 h protective ventilation, while control groups were ventilated using a conventional ventilation strategy at either high or low pressure. Pressure-volume curves (P(el)/V), blood gases, and haemodynamics were studied at 0, 4, 8, 16, and 24 h after the induction of ARDS and lung histology was evaluated.
  
  
  RESULTS
  The P(el)/V curves showed improvements in the protective strategy group and deterioration in both control groups. In the protective group, when respiratory rate (RR) was ≈ 60 bpm, better oxygenation and reduced shunt were found. Histological damage was significantly more severe in the high-pressure group. There were no differences in venous oxygen saturation and pulmonary vascular resistance between the groups.
  
  
  CONCLUSIONS
  The protective ventilation strategy of adequate pH or PaCO2 with minimal V(T), and high/safe P(PLAT) resulting in high PEEP was based on the avoidance of known lung-damaging phenomena. The approach is based upon the optimization of V(T), RR, PEEP, I/E, and dead space. This study does not lend itself to conclusions about the independent role of each of these features. However, dead space reduction is fundamental for achieving minimal V(T) at high RR. Classical physiology is applicable at high RR. Computer simulation optimizes ventilation and limiting of dead space using ASPIDS. Inspiratory P(el)/V curves recorded from PEEP or, even better, expiratory P(el)/V curves allow monitoring in ARDS.
authors: Department of Clinical Physiology, Lund University, Lund, Sweden.
authors: L
authors: L
authors: Uttman
authors: U
authors: U
authors: Bitzén
authors: E
authors: E
authors: De Robertis
authors: J
authors: J
authors: Enoksson
authors: L
authors: L
authors: Johansson
authors: B
authors: B
authors: Jonson
mesh_terms: D055371:Acute Lung Injury / Q000473:pathology / Q000628:therapy*; D000818:Animals; D001784:Blood Gas Analysis; D003198:Computer Simulation; D023381:Endpoint Determination; D006439:Hemodynamics / Q000502:physiology; D008168:Lung / Q000473:pathology; D016343:Monitoring, Intraoperative; D053717:Pneumonia, Ventilator-Associated / Q000628:therapy*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000473:pathology / Q000628:therapy*; D015656:Respiratory Mechanics / Q000502:physiology; D013552:Swine