title: MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.
abstract: Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.
authors: Henry Wellcome Laboratories for Integrative Neuroscience & Endocrinology & MRC Centre for Synaptic Plasticity, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, UK. helen.scott@bristol.ac.uk
authors: Helen L
authors: HL
authors: Scott
authors: Francesco
authors: F
authors: Tamagnini
authors: Katherine E
authors: KE
authors: Narduzzo
authors: Joanna L
authors: JL
authors: Howarth
authors: Youn-Bok
authors: YB
authors: Lee
authors: Liang-Fong
authors: LF
authors: Wong
authors: Malcolm W
authors: MW
authors: Brown
authors: Elizabeth C
authors: EC
authors: Warburton
authors: Zafar I
authors: ZI
authors: Bashir
authors: James B
authors: JB
authors: Uney
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D017774:Long-Term Potentiation / Q000235:genetics* / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000502:physiology*
chemical_list: C548821:MIRN132 microRNA, rat; D035683:MicroRNAs