title: Impact of oxidative stress in fetal programming.
abstract: Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.
authors: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 11-029 Bressler Research Building, 655 W. Baltimore Street, Baltimore, MD 21201, USA. lthompson@umm.edu
authors: Loren P
authors: LP
authors: Thompson
authors: Yazan
authors: Y
authors: Al-Hasan
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D047109:Fetal Development / Q000235:genetics / Q000502:physiology*; D005311:Fetal Hypoxia / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D039401:Prenatal Nutritional Physiological Phenomena; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species