title: Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats.
abstract: Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia is late. SDT fatty rat, established by introducing the fa allele of the Zucker fatty rat to SDT rat, develops diabetes much faster than SDT rat. In the present study, diabetic peripheral neuropathy (DPN) was evaluated to show the further usefulness of this animal model. Motor nerve conduction velocity (MNCV) was delayed, and the number of sural nerve fibers was decreased in SDT fatty rat. Treatment of pioglitazone lowered blood glucose level and prevented delay of MNCV in SDT fatty rats. SDT fatty rat is a useful animal model for studies of DPN in type 2 diabetes.
authors: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors: Takayuki
authors: T
authors: Yamaguchi
authors: Tomohiko
authors: T
authors: Sasase
authors: Yasuko
authors: Y
authors: Mera
authors: Daisuke
authors: D
authors: Tomimoto
authors: Hironobu
authors: H
authors: Tadaki
authors: Yusuke
authors: Y
authors: Kemmochi
authors: Takeshi
authors: T
authors: Ohta
authors: Eimei
authors: E
authors: Sato
authors: Mutsuyoshi
authors: M
authors: Matsushita
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004195:Disease Models, Animal; D007328:Insulin / Q000097:blood; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D000077205:Pioglitazone; D051381:Rats; D017207:Rats, Sprague-Dawley; D011924:Rats, Zucker; D013497:Sural Nerve / Q000166:cytology; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D045162:Thiazolidinediones; D000077205:Pioglitazone