title: Polymeric particulate technologies for oral drug delivery and targeting: a pathophysiological perspective.
abstract: The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.
authors: University of Manchester, Department of Pharmacy and Pharmaceutical Sciences, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom. christy.hunter@manchester.ac.uk
authors: A Christy
authors: AC
authors: Hunter
authors: Jacqueline
authors: J
authors: Elsom
authors: Peter P
authors: PP
authors: Wibroe
authors: S Moein
authors: SM
authors: Moghimi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D041981:Gastrointestinal Tract / Q000033:anatomy & histology / Q000378:metabolism* / Q000503:physiopathology / Q000648:ultrastructure; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers