title: Passenger lymphocyte syndrome with hemophagocytic syndrome after peripheral blood stem-cell transplantation from an HLA-matched full biological sibling: case report.
abstract: Massive hemolysis due to passenger lymphocyte syndrome (PLS) is rare after peripheral blood stem-cell (PBSC) transplantation with a minor ABO mismatch. We present, in a 16-year-old boy (group A Rh+), PLS with hemophagocytic syndrome (HPS) after PBSC transplantation from his HLA (human leukocyte antigens)-matched biological sister (group O Rh+). Mild-to-moderate hemolysis was evident from day +11 to day +15 after transplantation. HPS was diagnosed by bone marrow examination on day +16, while antibodies against the recipient's red blood cell antigens were detected on days +15 and +27. This hemolysis may have been due to PLS with HPS. Therefore, measurement of antibodies may provide a useful hallmark of immune hemolysis.
authors: Department of Blood Transfusion and Purification, National Defense Medical College Hospital, Tokorozawa 359-8513, Japan. sachi86@ndmc.ac.jp
authors: Sachiko
authors: S
authors: Iwanaga
authors: Takeshi
authors: T
authors: Sakaguchi
authors: Kuniaki
authors: K
authors: Nakanishi
authors: Mika
authors: M
authors: Furukuwa
authors: Kaori
authors: K
authors: Ishizeki
authors: Kazuhiro
authors: K
authors: Kogawa
authors: Akira
authors: A
authors: Tsuji
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D001787:Blood Group Incompatibility / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D035781:Siblings; D013577:Syndrome; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens