title: In vitro and in vivo biological activities of iron chelators and gallium nitrate against Acinetobacter baumannii.
abstract: We investigated the ability of compounds interfering with iron metabolism to inhibit the growth of Acinetobacter baumannii. Iron restriction with transferrin or 2,2-bipyridyl significantly inhibited A. baumannii growth in vitro. Gallium nitrate alone was moderately effective at reducing A. baumannii growth but became bacteriostatic in the presence of serum or transferrin. More importantly, gallium nitrate treatment reduced lung bacterial burdens in mice. The use of gallium-based therapies shows promise for the control of multidrug-resistant A. baumannii.
authors: Human Health Therapeutics Portfolio, National Research Council Canada, Ottawa, Ontario, Canada.
authors: Louis
authors: L
authors: de Léséleuc
authors: Greg
authors: G
authors: Harris
authors: Rhonda
authors: R
authors: KuoLee
authors: Wangxue
authors: W
authors: Chen
mesh_terms: D015082:2,2'-Dipyridyl / Q000494:pharmacology* / Q000627:therapeutic use; D000151:Acinetobacter Infections / Q000188:drug therapy; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000472:pathogenicity*; D000818:Animals; D005708:Gallium / Q000494:pharmacology* / Q000627:therapeutic use; D007502:Iron Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D014168:Transferrin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007502:Iron Chelating Agents; D014168:Transferrin; D015082:2,2'-Dipyridyl; D005708:Gallium; C027235:gallium nitrate