title: Fabrication of nanofiber scaffolds with gradations in fiber organization and their potential applications.
abstract: A new and simple method for fabrication of nanofiber scaffolds with gradations in fiber organization is reported. The nanofiber organization, achieved by deposition of random fibers on the uniaxially aligned nanofiber mat in a gradient manner, directed morphological changes of applied adipose-derived stem cells. These morphological changes and resultant biochemical changes can help mimic the structural orientation of complex biomechanical structures like the collagen fiber structure at the tendon-to-bone insertion site. In addition, chemical gradients can be established through nanoencapsulation in this novel scaffold allowing for enhanced biomedical applications.
authors: Marshall Institute for Interdisciplinary Research and Center for Diagnostic Nanosystems, Marshall University, Huntington, WV 25755, USA. xiej@marshall.edu
authors: Jingwei
authors: J
authors: Xie
authors: Bing
authors: B
authors: Ma
authors: Praveesuda Lorwattanapongsa
authors: PL
authors: Michael
authors: Franklin D
authors: FD
authors: Shuler
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D001842:Bone and Bones / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000138:chemical synthesis*; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone