title: The semen quality of 1158 men with testicular cancer at the time of cryopreservation: results of the French National CECOS Network.
abstract: Testicular cancer is the most common cancer in young men. Several studies  have reported an alteration in semen quality in nonseminoma tumors, but this  result has not been confirmed in all of the published data. We performed a  retrospective study in a population of 1158 men with testicular cancer who  banked sperm between 1999 and 2003 in 11 French Centre d'Etude et de  Conservation des Oeufs et du Sperme humain laboratories. Our study evaluated  prefreeze and postthaw sperm parameters according to patient medical history,  tumor histological type, and disease stage. Pure seminomas were found in 48%  of our population. Testicular cancer was generally diagnosed at stage I. In  cases of a history of unilateral cryptorchidism, testicular cancer occurred  preferentially in the maldescended testis. Semen samples were preferentially  collected after orchiectomy. The sperm concentration and total sperm number  were significantly lower before orchiectomy in seminomas compared with  nonseminoma tumors (P < .001). After orchiectomy, these parameters  decreased for nonseminoma tumors and did not vary for seminomas. Semen  parameters were more severely impaired for stage III tumors, and when patients  had a history of cryptorchidism or when they were less than 20 years of age.  Azoospermia was more frequently observed before than after orchiectomy. In  this study, we determined that sperm cryobanking should preferentially be  performed before orchiectomy and that testicular sperm extraction concurrent  with orchiectomy should be used in severe spermatogenesis impairment. Our  study highlights that seminomas alter sperm production more significantly than  nonseminoma tumors and seem to preferentially impair spermatogenesis in  tumor-bearing testes.
authors: Laboratoire de Biologie de la Reproduction–CECOS, Rouen, France. nathalie.rives@chu-rouen.fr
authors: Nathalie
authors: N
authors: Rives
authors: Anne
authors: A
authors: Perdrix
authors: Sylviane
authors: S
authors: Hennebicq
authors: Jacqueline
authors: J
authors: Saïas-Magnan
authors: Marie-Claude
authors: MC
authors: Melin
authors: Isabelle
authors: I
authors: Berthaut
authors: Claire
authors: C
authors: Barthélémy
authors: Myriam
authors: M
authors: Daudin
authors: Ethel
authors: E
authors: Szerman
authors: Jean-Luc
authors: JL
authors: Bresson
authors: Florence
authors: F
authors: Brugnon
authors: Louis
authors: L
authors: Bujan
mesh_terms: D000293:Adolescent; D000328:Adult; D015925:Cryopreservation / Q000379:methods*; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D009919:Orchiectomy; D012189:Retrospective Studies; D055101:Semen Analysis; D018239:Seminoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*