title: Neuroprotection of apelin and its signaling pathway.
abstract: Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a native ligand of the apelin receptor (APJ). Some research has found that apelin peptides alter blood pressure, feeding behavior, and pituitary hormone release. However, a new neuroprotective effect of apelin peptides was only recently discovered. This review summarizes the evidence of apelin-neuroprotection, which has the potential to cure acute and chronic neurological diseases.
authors: Department of Neurology, Jining Medical University, Jining City, Shandong Province, PR China. apple9red@yahoo.com.cn
authors: Baohua
authors: B
authors: Cheng
authors: Jing
authors: J
authors: Chen
authors: Bo
authors: B
authors: Bai
authors: Qing
authors: Q
authors: Xin
mesh_terms: D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D036341:Intercellular Signaling Peptides and Proteins; D018696:Neuroprotective Agents; D043562:Receptors, G-Protein-Coupled