title: Innate barriers to viral infection.
abstract: Innate immunity represents the foremost barrier to viral infection. In order to infect a cell efficiently, viruses need to evade innate immune effectors such as interferons and inflammatory cytokines. Pattern recognition receptors can detect viral components or pathogen-associated molecular patterns. These receptors then elicit innate immune responses that result in the generation of type I interferons and proinflammatory cytokines. Organized by the Society for General Microbiology, one session of this conference focused on the current state-of-the-art knowledge on innate barriers to infection of different RNA and DNA viruses. Experts working on innate immunity in the context of viral infection provided insight into different aspects of innate immune recognition and also discussed areas for future research. Here, we provide an overview of the session on innate barriers to infection.
authors: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA. damania@med.unc.edu
authors: Blossom
authors: B
authors: Damania
authors: David J
authors: DJ
authors: Blackbourn
mesh_terms: D016207:Cytokines / Q000276:immunology; D004267:DNA Viruses / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology; D012328:RNA Viruses / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology
chemical_list: D016207:Cytokines; D007370:Interferon Type I; D051192:Receptors, Pattern Recognition