title: [Indoor air guide values for cresols].
abstract: AbstractThe Ad-hoc Working Group on Indoor Guidelines of the Indoor Air Hygiene Committee and of the Supreme State Health Authorities in Germany is issuing indoor air guide values to protect public health. For health evaluation of cresols in indoor air upper airway irritation was seen as critical effect. Unfortunately, valid inhalation studies were not available. Therefore, results of a recent oral long term study with a mixture of cresols in male rats were used. The Working Group selected a BMDL10 of 13.9 mg cresols per kg body weight and day assessed by US-ATSDR as a point of departure. A path-to-path-extrapolation involved a breathing rate of 20 m3 per day, a body weight of 70 kg and an oral resorption rate of 50%. A factor of 10 each for interspecies and intraspecies variability, respectively, and a modifying factor of 2 regarding physiological differences in children were applied. Since data from inhalation studies indicated more pronounced airway irritation than data from oral studies an additional factor of 2 was introduced. A health hazard value (RW II) of 0.05 mg cresols/m3 and a precautionary value (RW I) of 0.005 mg cresols/m3 are recommended.
mesh_terms: D000336:Aerosols; D016902:Air Pollution, Indoor / Q000032:analysis*; D000818:Animals; D003408:Cresols / Q000032:analysis* / Q000493:pharmacokinetics / Q000633:toxicity; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D008657:Metabolic Clearance Rate / Q000502:physiology; D051379:Mice; D011634:Public Health; D051381:Rats; D012137:Respiratory System / Q000187:drug effects
chemical_list: D000336:Aerosols; D003408:Cresols