title: Alternatively folded proteins with unexpected beneficial functions.
abstract: HAMLET (human α-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the alternatively folded states. Beginning with the history of its discovery and development, the cellular targets that appear to be strongly correlated with tumour cell death are introduced in the present article.
authors: Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.
authors: Soyoung
authors: S
authors: Min
authors: James
authors: J
authors: Meehan
authors: Louise M
authors: LM
authors: Sullivan
authors: Níal P
authors: NP
authors: Harte
authors: Yongjing
authors: Y
authors: Xie
authors: Gavin P
authors: GP
authors: Davey
authors: Catharina
authors: C
authors: Svanborg
authors: André
authors: A
authors: Brodkorb
authors: K Hun
authors: KH
authors: Mok
mesh_terms: D000818:Animals; D017209:Apoptosis; D002417:Cattle; D006801:Humans; D007768:Lactalbumin / Q000737:chemistry* / Q000378:metabolism*; D019301:Oleic Acid / Q000737:chemistry* / Q000378:metabolism*; D009829:Oleic Acids / Q000737:chemistry* / Q000378:metabolism*; D017510:Protein Folding
chemical_list: C560443:BAMLET complex, Bos taurus; C506422:HAMLET complex, human; D009829:Oleic Acids; D019301:Oleic Acid; D007768:Lactalbumin