title: Solvent-free palladium-catalyzed direct arylation of heteroaromatics with aryl bromides.
abstract: Solvent is one of the major sources of waste in the course of catalyzed direct arylations. Some palladium-catalyzed direct arylations of heteroaromatics can be advantageously performed without any solvent. In the presence of palladium catalysts (1 mol %) and potassium acetate as the base, the direct 5-arylation of some thiazoles, thiophenes, furans, or pyrroles with aryl bromides as coupling partners proceeds highly regioselectively and in moderate to high yields. However, the use of these solvent-free conditions is limited to electron-deficient aryl bromides.
authors: Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes 1, Catalyse et Organometalliques, Campus de Beaulieu, 35042 Rennes, France.
authors: Souhila
authors: S
authors: Bensaid
authors: Henri
authors: H
authors: Doucet
mesh_terms: D001966:Bromine / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006841:Hydrocarbons, Aromatic; D010165:Palladium; D001966:Bromine