title: Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women.
abstract: OBJECTIVE
  We assessed the association of family history of type 2 diabetes (T2D) with parameters used for health checkups in young Japanese women.
  
  
  METHODS
  The subjects were 497 nondiabetic women aged 19-39 years. Among them, the mothers of 34 subjects and fathers of 50 had T2D (MD group and PD group, respectively). The subjects were assessed for levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG).
  
  
  RESULTS
  TC and LDL-C level showed a tendency to increase in the MD group compared with subjects without family history of T2D. LDL-C/HDL-C ratio ≥2.14 was found in 32.4 and 18.0 % of subjects in the MD and PD groups, respectively. When adjusted for differences in age, body mass index, smoking status, and drinking habits, the MD group was found to have a higher risk of abnormal TC and LDL-C levels than the PD group. LDL-C/HDL-C ratio was independently associated with maternal family history but not with paternal family history (odds ratio 3.44 [99 % confidence interval 1.11-10.6] and 1.21 [0.38-3.89], respectively). There was no association between TG/HDL-C ratio and family history type of T2D.
  
  
  CONCLUSIONS
  Maternal family history of T2D had a more pronounced effect on the lipid parameters generally evaluated during health checkups than did paternal family history of T2D. Therefore, we recommend systematic screening for early detection and appropriate healthcare guidance for Japanese women, particularly those with maternal family history of T2D.
authors: Sagamihara Public Health Center, 6-1-1 Fujimi, Chuo-ku, Sagamihara, Kanagawa 252-5277, Japan. kemal-s@umin.ac.jp
authors: Kemal
authors: K
authors: Sasaki
authors: Aya
authors: A
authors: Yoshida
authors: Hiroshi
authors: H
authors: Ohta
authors: Yoshiharu
authors: Y
authors: Aizawa
authors: Akiko
authors: A
authors: Kojima
authors: Hitomi
authors: H
authors: Chiba
authors: Shin
authors: S
authors: Mizuguchi
authors: Tatsunori
authors: T
authors: Ishidzuka
authors: Hiroshi
authors: H
authors: Goto
authors: Chiho
authors: C
authors: Uegaki
authors: Kyuhei
authors: K
authors: Kotake
mesh_terms: D000328:Adult; D000367:Age Factors; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics*; D005220:Fathers; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009035:Mothers; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides