title: Exploiting nutrient transporters at the blood-brain barrier to improve brain distribution of small molecules.
abstract: The blood-brain barrier (BBB) is a major physiological barrier for drugs that target CNS receptors or enzymes. Several methods exist by which permeability to the CNS can be increased, one of which is using native nutrient transporters to carry these drugs through the endothelial cells of the BBB. In this review, we focus on work that characterizes the use of nutrient transporters of the BBB in delivering drugs to the CNS.
authors: Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106-1712, USA.
authors: Rajendar K
authors: RK
authors: Mittapalli
authors: Vamshi K
authors: VK
authors: Manda
authors: Chris E
authors: CE
authors: Adkins
authors: Werner J
authors: WJ
authors: Geldenhuys
authors: Paul R
authors: PR
authors: Lockman
mesh_terms: D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000502:physiology; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D027702:Organic Cation Transporter 1 / Q000502:physiology
chemical_list: D051272:Glucose Transporter Type 1; D026901:Membrane Transport Proteins; D027702:Organic Cation Transporter 1; C065637:choline transporter; D002794:Choline