title: Plasma levels of antibodies against oxidized LDL are inherited but not associated with HDL-cholesterol level in families with early coronary heart disease.
abstract: OBJECTIVE
  Oxidized low-density lipoproteins (oxLDL) and antibodies against them (anti-oxLDLs) are thought to play a central role in atherosclerosis. One proposed antiatherosclerotic mechanism for HDL is to prevent oxidation of LDL. This study examined whether plasma HDL-cholesterol (HDL-C) is related to plasma anti-oxLDL levels.
  
  
  METHODS
  We collected families based on probands with low HDL-C and premature coronary heart disease (CHD). Antibody levels were determined in samples from 405 subjects. Immunoglobulin G, M and A levels against two in vitro models of oxLDL, malondialdehyde-acetaldehyde-modified LDL (MAA-LDL) and copper oxidized LDL (CuOx-LDL), were measured by ELISA. We carried out heritability estimation of antibody traits and bivariate analyses between HDL-C, LDL-C and antibody traits.
  
  
  RESULTS
  All the antibody levels were significantly inherited (p < 0.001), heritability estimates ranging from 0.28 to 0.65. HDL-C exhibited no environmental or genetic cross-correlations with antibody levels. Significant environmental correlations were detected between LDL-C and both IgG levels (ρ(E) = 0.40, p = 0.046 and ρ(E) = 0.39, p < 0.001). There were no differences in antibody levels between subjects with normal and low HDL-C, or between CHD-affected and non-affected subjects.
  
  
  CONCLUSIONS
  In this study, low HDL-C level displayed no significant associations with the anti-oxLDL levels measured. The heritability of the anti-oxLDL levels was a novel and interesting finding.
authors: Department of Internal Medicine, Biocenter Oulu and Clinical Research Center, University of Oulu, Aapistie 5A, 90220 Oulu, Finland.
authors: Timo
authors: T
authors: Paavola
authors: Tiia
authors: T
authors: Kangas-Kontio
authors: Tuire
authors: T
authors: Salonurmi
authors: Sanna
authors: S
authors: Kuusisto
authors: Tuija
authors: T
authors: Huusko
authors: Markku J
authors: MJ
authors: Savolainen
authors: Sakari
authors: S
authors: Kakko
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000235:genetics*; D050197:Atherosclerosis / Q000276:immunology; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D005192:Family Health; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000906:Antibodies; D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein