title: A novel and green biomaterial based silver nanocomposite hydrogel: synthesis, characterization and antibacterial effect.
abstract: In the present study, we report a facile and eco-friendly method for the preparation of a novel silver nanocomposite hydrogel (SNH) based on poly(acrylic acid) (PAA) grafted onto salep as a water soluble polysaccharide backbone. The presence of inorganic silver nanoparticles (nano-Ag) in the hydrogel was confirmed by thermo-gravimetric (TG) analysis. The TEM images illustrated the presence of embedded nano-Ag throughout the hydrogel matrix. In addition, the transmission electron microscopy (TEM) images showed that the formed nano-Ag had an average particle size of 5-10 nm. The potential of obtained SNH was examined for Tetracycline hydrochloride (TH) release in simulated colon conditions. Lastly, the in vitro antibacterial properties of the obtained optimum sample were successfully evaluated against gram-negative and gram-positive bacteria.
authors: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran. rezanejad@pnu.ac.ir
authors: Ghasem R
authors: GR
authors: Bardajee
authors: Zari
authors: Z
authors: Hooshyar
authors: Habib
authors: H
authors: Rezanezhad
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001672:Biocompatible Materials; D004926:Escherichia coli / Q000187:drug effects; D055772:Green Chemistry Technology; D020100:Hydrogels; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology; D013818:Thermogravimetry
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D020100:Hydrogels; D012834:Silver; C006903:carbopol 940; D013752:Tetracycline