title: Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA).
abstract: The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times.
authors: Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany.
authors: Daniel P
authors: DP
authors: Fiege
authors: Sandro
authors: S
authors: Romanzetti
authors: Christian C
authors: CC
authors: Mirkes
authors: Daniel
authors: D
authors: Brenner
authors: N Jon
authors: NJ
authors: Shah
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D003287:Contrast Media / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012964:Sodium / Q000378:metabolism*; D012975:Sodium Isotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D012975:Sodium Isotopes; D012964:Sodium