title: An 1,3,4-oxadiazole-based OFF-ON fluorescent chemosensor for Zn2+ in aqueous solution and imaging application in living cells.
abstract: A new 1,3,4-oxadiazole-based fluorescence chemosensor 1, N-(2-ethoxy-2-oxoethyl)-N-(5-(2-hydroxy-3,5-di-tert-butylphenyl)-[1,3,4]oxadiazol-2-yl)glycine ethyl ester, has been designed and synthesized. Its fluorescence properties and selectivity for various metal ions were investigated in detail. A prominent fluorescence enhancement only for Zn(2+) was found in aqueous acetonitrile solution and the response mechanism of 1 was analyzed by time-resolved fluorescence decay and DFT calculations. Furthermore, the fluorescence imaging of Zn(2+) in living cells was successfully applied.
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, PR China.
authors: Ji-An
authors: JA
authors: Zhou
authors: Xiao-Liang
authors: XL
authors: Tang
authors: Ju
authors: J
authors: Cheng
authors: Zheng-Hua
authors: ZH
authors: Ju
authors: Li-Zi
authors: LZ
authors: Yang
authors: Wei-Sheng
authors: WS
authors: Liu
authors: Chun-Yang
authors: CY
authors: Chen
authors: De-Cheng
authors: DC
authors: Bai
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D010069:Oxadiazoles / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000032:analysis*
chemical_list: D000097:Acetonitriles; D005456:Fluorescent Dyes; D010069:Oxadiazoles; D014867:Water; D015032:Zinc; C032159:acetonitrile