title: Study of wound-healing activity of bioregulators isolated from eye tissues and bovine serum in the model of experimental corneal injury in rabbits in vivo.
abstract: We compared wound-healing activity of bioregulators isolated from cattle cornea, serum, and retinal pigment epithelium on in vivo model of experimental corneal injury in rabbits. Bioregulators were instilled into the eye as solutions at a concentration corresponding to 10(-12) mg protein/ml. The animals were sacrificed on day 21 after injury and the corneas were examined histologically. The best wound-healing effect was produced by bioregulators isolated from the cornea and serum and instilled successively into rabbit eyes with an interval of 15-20 min twice a day: multicellular epithelium was observed in the wound, and slight inflammation, in the stroma.
authors: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors: A A
authors: AA
authors: Konstantinovsky
authors: M S
authors: MS
authors: Krasnov
authors: V P
authors: VP
authors: Yamskova
authors: E Yu
authors: EY
authors: Rybakova
authors: I A
authors: IA
authors: Yamskov
mesh_terms: D000818:Animals; D002417:Cattle / Q000097:blood; D003315:Cornea / Q000737:chemistry*; D065306:Corneal Injuries; D019573:Epithelium, Corneal / Q000293:injuries*; D005131:Eye Injuries / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D055213:Retinal Pigment Epithelium / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*