title: Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats?
abstract: Based on the limited number of studies that have investigated the adverse effects of maternal treatment with antidepressants on the development of male descendents, this study was carried out in rat in order to evaluate if maternal exposure to fluoxetine (FLX) or St. John's Wort (SJW) could disrupt the development of male offspring. The dams were treated daily, by gavage, with 7.5 mg/kg of FLX or 100 mg/kg SJW during pregnancy and lactation. The reproductive and behavior parameters were analyzed in male pups. Results showed decreases in the weight of the full seminal vesicle and in the number of spermatozoa. Moreover, FLX-exposed pups presented reduced seminiferous epithelium height and diameter of seminiferous tubules. The present study shows that maternal exposure to FLX, but not SJW could interfere on reproductive parameters in adult male rats.
authors: Department of Physiological Sciences, State University of Londrina-UEL, Londrina, Paraná, Brazil.
authors: Milene Leivas
authors: ML
authors: Vieira
authors: Renata Yumi
authors: RY
authors: Hamada
authors: Natalia Ignácio
authors: NI
authors: Gonzaga
authors: Andre Demambre
authors: AD
authors: Bacchi
authors: Mainara
authors: M
authors: Barbieri
authors: Estefânia Gastaldello
authors: EG
authors: Moreira
authors: Suzana de Fátima Paccola
authors: Sde F
authors: Mesquita
authors: Daniela Cristina Ceccatto
authors: DC
authors: Gerardin
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000633:toxicity*; D005260:Female; D005473:Fluoxetine / Q000633:toxicity*; D020902:Hypericum / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012725:Sexual Behavior / Q000187:drug effects; D046468:Sexual Development / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D013739:Testosterone