title: zCall: a rare variant caller for array-based genotyping: genetics and population analysis.
abstract: CONCLUSIONS
  zCall is a variant caller specifically designed for calling rare single-nucleotide polymorphisms from array-based technology. This caller is implemented as a post-processing step after a default calling algorithm has been applied. The algorithm uses the intensity profile of the common allele homozygote cluster to define the location of the other two genotype clusters. We demonstrate improved detection of rare alleles when applying zCall to samples that have both Illumina Infinium HumanExome BeadChip and exome sequencing data available.
  
  
  BACKGROUND
  http://atguweb.mgh.harvard.edu/apps/zcall.
  
  
  BACKGROUND
  bneale@broadinstitute.org
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors: Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors: Jacqueline I
authors: JI
authors: Goldstein
authors: Andrew
authors: A
authors: Crenshaw
authors: Jason
authors: J
authors: Carey
authors: George B
authors: GB
authors: Grant
authors: Jared
authors: J
authors: Maguire
authors: Menachem
authors: M
authors: Fromer
authors: Colm
authors: C
authors: O'Dushlaine
authors: Jennifer L
authors: JL
authors: Moran
authors: Kimberly
authors: K
authors: Chambert
authors: Christine
authors: C
authors: Stevens
authors: Pamela
authors: P
authors: Sklar
authors: Christina M
authors: CM
authors: Hultman
authors: Shaun
authors: S
authors: Purcell
authors: Steven A
authors: SA
authors: McCarroll
authors: Patrick F
authors: PF
authors: Sullivan
authors: Mark J
authors: MJ
authors: Daly
authors: Benjamin M
authors: BM
authors: Neale
mesh_terms: D000465:Algorithms; D000483:Alleles; D016000:Cluster Analysis; D059472:Exome; D060005:Genotyping Techniques; D006720:Homozygote; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012984:Software