title: [Impact of cytomegalovirus infections on T lymphocyte subsets in children with β-thalassemia major early after allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To investigate the effect of human cytomegalovirus (HCMV) infection on T lymphocyte subsets in children with β-thalassemia major (TM) during the initial 6 months after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).
  
  
  METHODS
  From January, 2010 to January, 2011, 35 children with TM underwent Allo-HSCT. Peripheral blood samples were obtained from the children 6 month after the transplantation to examine the changes of T lymphocytes subsets in relation to HCMV seropositivity.
  
  
  RESULTS
  Thirteen children were found seropositive and 22 were seronegative for HCMV. The HCMV-seropositive children had a higher CD8⁺ cell percentage but a lower CD4⁺ cell percentage than those without HCMV infection. Compared with those seronegative for HCMV, the children with HCMV seropositivity showed increased percentages of CD8⁺ cells and CD8⁺CD28⁻ cells with a decreased percentage of CD8⁺CD28⁺ cells. A positive linear correlation was found between the percentages of CD8⁺CD28⁻ cells and CD8⁺ cells.
  
  
  CONCLUSIONS
  HCMV infection can lead to the accumulation of CD8⁺CD28 cells to cause increased CD8⁺ T cells in the peripheral blood in TM children after Allo-HSCT. The percentages of CD8⁺CD28⁻ cells has a positive linear correlation to that of CD8⁺ cells.
authors: Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wangyanhua4310@163.com
authors: Yanhua
authors: Y
authors: Wang
authors: Xuedong
authors: X
authors: Wu
authors: Xiaoqin
authors: X
authors: Feng
authors: Yuelin
authors: Y
authors: He
authors: Fuyu
authors: F
authors: Pei
authors: Chunfu
authors: C
authors: Li
mesh_terms: D000293:Adolescent; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D011184:Postoperative Period; D016176:T-Lymphocyte Subsets; D017086:beta-Thalassemia / Q000276:immunology* / Q000601:surgery / Q000821:virology*