title: Antibacterial activities of iron chelators against common nosocomial pathogens.
abstract: The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
authors: Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
authors: Mitchell G
authors: MG
authors: Thompson
authors: Brendan W
authors: BW
authors: Corey
authors: Yuanzheng
authors: Y
authors: Si
authors: David W
authors: DW
authors: Craft
authors: Daniel V
authors: DV
authors: Zurawski
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077543:Deferiprone; D003676:Deferoxamine / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011728:Pyridones / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D003676:Deferoxamine