title: Biodistribution of ultra small gadolinium-based nanoparticles as theranostic agent: application to brain tumors.
abstract: Gadolinium-based nanoparticles are novel objects with interesting physical properties, allowing their use for diagnostic and therapeutic applications. Gadolinium-based nanoparticles were imaged following intravenous injection in healthy rats and rats grafted with 9L gliosarcoma tumors using magnetic resonance imaging and scintigraphic imaging. Quantitative biodistribution using gamma-counting of each sampled organ confirmed that these nanoparticles were rapidly cleared essentially by renal excretion. Accumulation of these nanoparticles in 9L gliosarcoma tumors implanted in the rat brain was quantitated. This passive and long-duration accumulation of gadolinium-based nanoparticles in tumor, which is related to disruption of the blood-brain barrier, is in good agreement with the use of these nanoparticles as radiosensitizers for brain tumors.
authors: Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS, Université Claude Bernard Lyon 1, Villeurbanne Cedex, France. melle_miladi@yahoo.fr
authors: Imen
authors: I
authors: Miladi
authors: Géraldine Le
authors: GL
authors: Duc
authors: David
authors: D
authors: Kryza
authors: Aurélie
authors: A
authors: Berniard
authors: Pierre
authors: P
authors: Mowat
authors: Stéphane
authors: S
authors: Roux
authors: Jacqueline
authors: J
authors: Taleb
authors: Pauline
authors: P
authors: Bonazza
authors: Pascal
authors: P
authors: Perriat
authors: François
authors: F
authors: Lux
authors: Olivier
authors: O
authors: Tillement
authors: Claire
authors: C
authors: Billotey
authors: Marc
authors: M
authors: Janier
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy*; D005682:Gadolinium / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000627:therapeutic use*; D051381:Rats; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D005682:Gadolinium