title: Genetic testing by cancer site: uterus.
abstract: This review article discusses hereditary cancer predisposition syndromes with uterine manifestations. Lynch syndrome accounts for 2% to 3% of endometrial cancers. The identification of endometrial cancer patients at risk for Lynch syndrome is discussed, as are the characteristics of Lynch syndrome-associated endometrial cancer and the screening and prevention options for women at risk for Lynch syndrome-associated endometrial cancer. Endometrial cancer associated with PTEN hamartoma tumor syndrome (also known as Cowden syndrome) is also discussed. HLRCC (hereditary leiomyomatosis and renal cell carcinoma), which has an associated high risk of symptomatic uterine leiomyomas, is reviewed.
authors: Clinical Cancer Genetics Program, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors: Molly S
authors: MS
authors: Daniels
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics; D005260:Female; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D018231:Leiomyomatosis / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D012878:Skin Neoplasms; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000235:genetics*