title: Metastasectomy of Krukenberg tumors may be associated with survival benefits in patients with metastatic gastric cancer.
abstract: BACKGROUND
  The current standard treatment for patients with metastatic gastric cancer (MGC) is systemic chemotherapy. For gastric cancer patients with ovarian metastases, i.e. Krukenberg tumors, it is not known whether metastasectomy is associated with additional benefits.
  
  
  METHODS
  All patients who were diagnosed with gastric cancer and ovarian metastases between March 2000 and July 2010 in a medical center were included in the current study. The clinicopathological features and the treatment records were reviewed in detail and their association with overall survival (OS) was analyzed.
  
  
  RESULTS
  A total of 85 patients were identified. Thirty five (41.2%) and 50 (58.8%) patients did and did not undergo metastasectomy of Krukenberg tumors, respectively. The performance status and the proportion of patients receiving subsequent systemic therapy were well-matched between the two groups. Regarding disease status, patients who underwent metastasectomy had significantly larger Krukenberg tumors, pronounced bilateral disease and less extensive metastases outside the ovaries than patients who did not undergo metastasectomy. Patients who underwent metastasectomy had a better OS [median=14.1 months; 95% confidence interval (CI)=8.6-19.6 months] than patients who did not undergo metastasectomy (median OS=8 months; 95% CI=5.6-10.4 months, p=0.001). There was no aberrant postoperative morbiditie rate observed, and the median length of hospital stay after metastasectomy alone was 6 days. Based on multivariate analysis, metastasectomy remained an independent predictor of better OS (hazard ratio=0.36, p=0.002). The administration of subsequent systemic therapy, the use of platinum-based chemotherapy, and a better performance status also predict a better OS.
  
  
  CONCLUSIONS
  Metastasectomy of Krukenberg tumors may be associated with survival benefits in patients with MGC. Further prospective studies are warranted.
authors: Department of Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 10002, Taiwan, R.O.C.
authors: Li-Chun
authors: LC
authors: Lu
authors: Yu-Yun
authors: YY
authors: Shao
authors: Chih-Hung
authors: CH
authors: Hsu
authors: Chiun
authors: C
authors: Hsu
authors: Wen-Fang
authors: WF
authors: Cheng
authors: Yu-Lin
authors: YL
authors: Lin
authors: Ann-Lii
authors: AL
authors: Cheng
authors: Kun-Huei
authors: KH
authors: Yeh
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007725:Krukenberg Tumor / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000556:secondary* / Q000601:surgery*; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology*