title: Different peripheral neuroendocrine responses to Trypanosoma cruzi infection in mice lacking adaptive immunity.
abstract: Trypanosoma cruzi infection in mice triggers neuroendocrine responses that affect the course of the disease. To analyze the contribution of adaptive immunity to these responses, comparative studies between normal C57Bl/6J and recombinase activator gene 1 (RAG-1)-deficient mice, which lack mature B and T lymphocytes, were performed. There was no difference between both types of mice in basal body weight. Following infection, higher parasitemia, increased IL-1β and IL-6 blood levels, less marked changes in lymphoid organs weight, no cardiomegaly, and earlier mortality were observed in RAG-1-deficient, compared with normal mice. The response of the hypothalamus-pituitary-adrenal axis after infection occurred earlier and was more intense in RAG-1-deficient mice than in normal mice. Noradrenaline concentration and serotonergic metabolism in the spleen, lymph nodes, and heart differed between RAG-1-deficient and normal mice. Our studies indicate that the absence of adaptive immunity to T. cruzi influences the neuroendocrine response to the infection with this parasite.
authors: CAECHIS, Universidad Abierta Interamericana, Rosario, Argentina.
authors: Eduardo
authors: E
authors: Roggero
authors: Johannes
authors: J
authors: Wildmann
authors: Marcelo O
authors: MO
authors: Passerini
authors: Adriana
authors: A
authors: del Rey
authors: Hugo O
authors: HO
authors: Besedovsky
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology*; D003345:Corticosterone / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D018398:Homeodomain Proteins / Q000235:genetics / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D015213:Neuroimmunomodulation; D009490:Neurosecretory Systems / Q000276:immunology* / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000276:immunology
chemical_list: D016207:Cytokines; D018398:Homeodomain Proteins; C064658:RAG-1 protein; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003345:Corticosterone; D009638:Norepinephrine