title: Nuclear factor-κB signalling and transcriptional regulation in skeletal muscle atrophy.
abstract: The nuclear factor-κB (NF-κB) signalling pathway is a necessary component of adult skeletal muscle atrophy resulting from systemic illnesses or disuse. Studies showing a role for the NF-κB pathway in muscle disuse include unloading, denervation and immobilization, and studies showing a role for NF-κB in systemic illnesses include cancer, chronic heart failure and acute septic lung injury. Muscle atrophy due to most of these triggers is associated with activation of NF-κB transcriptional activity. With the exception of muscle unloading, however, there is a paucity of data on the NF-κB transcription factors that regulate muscle atrophy, and little is known about which genes are targeted by NF-κB transcription factors during atrophy. Interestingly, in some cases it appears that the amelioration of muscle atrophy by genetic inhibition of NF-κB signalling proteins is due to effects that are independent of the downstream NF-κB transcription factors. These questions are prime areas for investigation if we are to understand a key component of muscle wasting in adult skeletal muscle.
authors: Boston University, Department of Health Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA.
authors: Robert W
authors: RW
authors: Jackman
authors: Evangeline W
authors: EW
authors: Cornwell
authors: Chia-Ling
authors: CL
authors: Wu
authors: Susan C
authors: SC
authors: Kandarian
mesh_terms: D000328:Adult; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D018482:Muscle, Skeletal / Q000473:pathology; D009133:Muscular Atrophy / Q000378:metabolism* / Q000473:pathology; D016328:NF-kappa B / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D015533:Transcriptional Activation / Q000502:physiology
chemical_list: D016328:NF-kappa B; D014157:Transcription Factors