title: Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients.
abstract: Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory condition, involving airways and lung parenchyma. The disease leads to airflow limitation, and pulmonary hyperinflation, resulting in dyspnea, decreased exercise tolerance, and impaired quality of life. COPD pharmacotherapy guidelines are based on a combination of long-acting beta2-agonists (LABA), long-acting antimuscarinic agents (LAMA) and methyloxantins. Recently, indacaterol, ultralong acting beta2-agonist, has been introduced. The aim of our study was to assess the impact of indacaterol add-on therapy on lung function, exercise tolerance and quality of life of COPD patients. Thirty four COPD patients, receiving stable bronchodilator therapy were randomly allocated into two arms of add-on treatment (1:1 - indacaterol:placebo) for 3 months. Indacaterol replaced LABA in all patients receiving LABA. Spirometry, lung volumes, DLCO, St George's Respiratory Questionnaire (SGRQ) and 6 min Walk Distance (6MWD) were performed before and after therapy. We found that in the indacaterol group FEV1 did not changed significantly. However, there were significant improvements in ERV, 6MWD, and 6MWD-related dyspnea score. We also found that the degree of desaturation before and after 6MWD, and fatigue levels significantly improved in the indacaterol group. The patients' quality of life also changed favorably in the indacaterol treatment arm. We conclude that the add-on therapy with indacaterol exerts positive effects in COPD patients.
authors: Department of Lung Diseases, Medical University of Bialystok, Zurawia 14, Bialystok, Poland. robmroz@wp.pl
authors: R M
authors: RM
authors: Mroz
authors: L
authors: L
authors: Minarowski
authors: E
authors: E
authors: Chyczewska
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists; D000368:Aged; D001993:Bronchodilator Agents / Q000627:therapeutic use; D004417:Dyspnea / Q000188:drug therapy; D015444:Exercise; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D012123:Pulmonary Ventilation / Q000187:drug effects*; D011788:Quality of Life; D015363:Quinolones / Q000627:therapeutic use*; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D007189:Indans; D018727:Muscarinic Antagonists; D015363:Quinolones; D018343:Receptors, Adrenergic, beta-2; C510790:indacaterol