title: Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile.
abstract: Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six HD patients and 28 healthy volunteers were enrolled into the study. Ten HD patients suffered from coronary heart disease (CHD). Perilipin-1, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), body mass index, albumin, geriatric nutritional risk index, normalized protein catabolic rate, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured. Perilipin-1 did not differ between HD patients and healthy volunteers. IL-6 and TNF-α were higher in HD patients. The evaluated nutritional markers and the markers of inflammation did not differ between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels. Regarding the lipid profile, only HDL-C differed between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels, and it was higher in the first subgroup. Perilipin-1 was significantly higher in HD patients without CHD. Perilipin-1 is detectable in the serum of HD patients and it is associated with increased HDL-C and decreased incidence of CHD.
authors: Nephrology Department, Medical School, University of Thessaly, Larissa, Greece. teleftheriadis@yahoo.com
authors: Theodoros
authors: T
authors: Eleftheriadis
authors: Georgia
authors: G
authors: Antoniadi
authors: Vassilios
authors: V
authors: Liakopoulos
authors: Georgios
authors: G
authors: Pissas
authors: Spyridon
authors: S
authors: Arampatzis
authors: Theodora
authors: T
authors: Sparopoulou
authors: Grammati
authors: G
authors: Galaktidou
authors: Ioannis
authors: I
authors: Stefanidis
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000097:blood*; D008875:Middle Aged; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000097:blood*; D006435:Renal Dialysis / Q000379:methods; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D008055:Lipids; C000602978:PLIN1 protein, human; D000070778:Perilipin-1; D010750:Phosphoproteins