title: Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles.
abstract: The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.
authors: Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
authors: Sheng-Ying
authors: SY
authors: Hsieh
authors: Michael
authors: M
authors: Binanzer
authors: Imants
authors: I
authors: Kreituss
authors: Jeffrey W
authors: JW
authors: Bode
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007700:Kinetics; D013237:Stereoisomerism
chemical_list: D000588:Amines; D006571:Heterocyclic Compounds