title: Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury.
abstract: Horizontal information transfer between cells via microparticles is a newly identified communication system. MicroRNAs regulate gene expression and are detected in microparticles. Cantaluppi et al. suggest that microparticles derived from circulating angiogenic cells--'endothelial progenitor cells' (EPCs)--harbor endothelial-protective miRNAs such as miR-126 and that delivery of EPC-derived microparticles during acute kidney ischemia-reperfusion in rats ameliorates kidney dysfunction and damage. We highlight the importance, potential future impact, and limitations of this study.
authors: Markus
authors: M
authors: Bitzer
authors: Iddo Z
authors: IZ
authors: Ben-Dov
authors: Thomas
authors: T
authors: Thum
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D055252:Cell-Derived Microparticles / Q000637:transplantation*; D042783:Endothelial Cells / Q000637:transplantation*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D015427:Reperfusion Injury / Q000517:prevention & control*; D033581:Stem Cell Transplantation; D013234:Stem Cells
chemical_list: D035683:MicroRNAs