title: A preliminary study of the relationship between the long arm of the Y chromosome (Yqh+) and reproductive outcomes in IVF/ICSI-ET.
abstract: OBJECTIVE
  To compare the reproductive outcomes of Yqh+-carrying and control couples undergoing IVF/ICSI treatments.
  
  
  METHODS
  Retrospective analysis of 72 Yqh+ carriers and 986 Yqh+ non-carriers undergoing their first cycle of ART in a single centre between August 2005 and May 2011.
  
  
  RESULTS
  Yqh+ carrying couples had significantly worse reproductive outcomes compared with control couples undergoing IVF treatment. There were a significantly higher cancellation rate (20.69% vs 7.9%; P<0.05; OR, 3.03; CI, 1.18-7.79) and a significant lower fertilisation rate (50.05% vs 66.01%; P<0.05; OR, 0.61; CI, 0.49-0.57), implantation rate (8.33% vs 20.87%; P<0.05; OR, 0.35; CI, 0.14-0.87), good quality embryo ratio (44.70% vs 57.89%; P<0.05; OR, 0.59; CI, 0.43-0.80) and clinical pregnancy rate (17.39% vs 39.59%; P<0.05; OR, 0.32; CI, 0.11-0.96) in Yqh+ group compared with control group undergoing IVF treatment. Yqh+ carrying couples had similar reproductive outcomes compared with control couples undergoing ICSI treatment.
  
  
  CONCLUSIONS
  The Y chromosome polymorphic variant Yqh+ most likely plays a role in infertility. Yqh+ couples with poor reproductive outcomes in IVF treatment can be advised to undergo ICSI to improve their reproductive results in the next cycle.
authors: Centre for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan 430060, China.
authors: Zhuoni
authors: Z
authors: Xiao
authors: Xin
authors: X
authors: Zhou
authors: Wangming
authors: W
authors: Xu
authors: Jing
authors: J
authors: Yang
mesh_terms: D002681:China / Q000453:epidemiology; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004477:Ectogenesis; D010064:Embryo Implantation; D004624:Embryo Transfer; D005191:Family Characteristics; D005260:Female; D006579:Heterozygote; D006785:Hospitals, University; D006801:Humans; D007246:Infertility / Q000628:therapy; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D025064:Sex Chromosome Disorders / Q000235:genetics / Q000503:physiopathology*; D020554:Sperm Injections, Intracytoplasmic