title: The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population.
abstract: Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw*06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw alleles and functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw*06 allele and PsV (P corrected = 0.0013) that was most prominent in early onset disease subtype (P corrected = 0.0013). The association between HLA-Cw*06 and PsA was low (P corrected = 0.0585) and restricted to PsA patients with early PsV onset (P corrected = 0.0195). We found no association of -1149 G/T PRL gene polymorphism with either PsV or PsA.
authors: Department of General Biology and Genetics, Third Faculty of Medicine, Charles University in Prague, Ruska 87, 10000 Prague 10, Czech Republic. anna.cibulova@seznam.cz
authors: Anna
authors: A
authors: Cibulova
authors: Marta
authors: M
authors: Zajacova
authors: Marketa
authors: M
authors: Fojtikova
authors: Jiri
authors: J
authors: Stolfa
authors: Liliana
authors: L
authors: Sedova
authors: Pavlina
authors: P
authors: Cejkova
authors: Jan
authors: J
authors: Lippert
authors: Petr
authors: P
authors: Arenberger
authors: Marie
authors: M
authors: Cerna
mesh_terms: D000328:Adult; D000483:Alleles; D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology; D018153:Czech Republic; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011388:Prolactin / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D044465:White People / Q000235:genetics
chemical_list: D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; D011388:Prolactin