title: The deleterious effects of physical inactivity on elements of insulin resistance and metabolic syndrome in Central Africans at high cardiovascular risk.
abstract: OBJECTIVE
  We aimed to describe the physical activity and to investigate the association between classical hypertension, obesity, diabetes, and new inflammation, IDF-defined metabolic syndrome, insulin resistance CV risk factors.
  
  
  METHODS
  This was a cross-sectional study based on interviews and physical and biochemistry measurements among Central African patients.
  
  
  METHODS
  Waist circumference (WC), blood pressure, weight and height to calculate body mass index (BMI), fasting glucose, CRP, ERS, uric acid, cholesterol (C), LDL-C, HDL-C, triglycerides, elements of homeostatic model assessment (HOMA) including insulin, HOMA index, QUICKI, insulin sensitivity (%S), beta-cell function (%β) and insulin resistance (IR).
  
  
  RESULTS
  Of the 60 patients included, 30 (50%) were physically inactive versus 30 (50%) active. In pooled analyses, in men and in women, there was significant and positive correlation between WC and seating/laying down position (WC=92.41+1.49 seating time in hours, R(2)=0.11; P<0.0001). The mean value of CRP and ERS were higher and those of all indices of HOMA were lower in inactive patients. The discriminant function for physical activity was Z (score=barycentre)=-7.36+1.013 HOMA index where -1.4 was the barycentre for active and +1.4 for inactive. HOMA index >2.42 was the optimal cut-off value to detect physically inactive patients: sensitivity=93.3%, specificity=100%, area under ROC=0.991±0.01 95%=0.975-1.0; P<0.0001.
  
  
  CONCLUSIONS
  The association between low-grade inflammation markers, insulin resistance and physical inactivity favours the hypothesis that a low-grade inflammatory status and enhanced insulin, sensitivity may constitute a part of the CV benefits from physical activity.
authors: Walter Sisulu University, Faculty of Health Sciences PO BOX 1127, Mthatha, South Africa. longombenza@yahoo.fr
authors: Benjamin
authors: B
authors: Longo-Mbenza
authors: Huguette
authors: H
authors: Nkongo Mvindu
authors: Jean Bosco
authors: JB
authors: Kasiam On'kin
authors: Nkakudulu
authors: N
authors: Bikuku
authors: Bernard
authors: B
authors: Kianu Phanzu
authors: Augustin
authors: A
authors: Nge Okwe
authors: Nelly
authors: N
authors: Kabangu
mesh_terms: D000328:Adult; D000350:Africa, Central / Q000208:ethnology; D044383:Black People / Q000208:ethnology; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology* / Q000503:physiopathology*; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009765:Obesity / Q000208:ethnology / Q000503:physiopathology; D012307:Risk Factors; D055105:Waist Circumference / Q000502:physiology