title: Serum dehydroepiandrosterone-sulfate reflects age better than health status, and may increase with cigarette smoking and alcohol drinking in middle-aged men.
abstract: OBJECTIVE
  Serum dehydroepiandrosterone- sulfate (DHEAS), the most abundant adrenal steroid hormone, may predict aging status and longevity in humans. The aims of this study are to clarify the fundamental properties of serum DHEAS as a biomarker for health in middle-aged men.
  
  
  METHODS
  We investigated correlations of serum DHEAS with age or conventional health indices (body mass index, blood pressure, and 12 serum/blood tests) and associations of serum DHEAS with lifestyle factors (smoking, drinking, exercise, sleep) in 384 healthy men aged 30-49 years, randomly selected from voluntary attendees at a checkup.
  
  
  RESULTS
  Serum DHEAS had an inverse and stronger correlation with age (Spearman's r=-0.320, p<0.001) than with any conventional health indices used here. Regardless of age and BMI adjustments, serum DHEAS had a weak correlation with serum uric acid (crude Spearman's r=0.198, p<0.001), and its correlations with other conventional health indices were weaker or non-significant. Serum DHEAS rose in parallel with increased smoking and alcohol intake (p for trend <0.001 in both), but had no significant relationships with exercise or sleep.
  
  
  CONCLUSIONS
  Serum DHEAS reflects age better than health status evaluated by conventional health indices, and may increase with cigarette smoking and alcohol drinking in middle-aged healthy men.
authors: Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. nterubo@med.nagoya-cu.ac.jp
authors: Teruo
authors: T
authors: Nagaya
authors: Yasuaki
authors: Y
authors: Kondo
authors: Toshio
authors: T
authors: Okinaka
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D000428:Alcohol Drinking / Q000009:adverse effects / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D015444:Exercise; D006304:Health Status; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012890:Sleep; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D019314:Dehydroepiandrosterone Sulfate