title: Ultrasound-promoted one-pot, three-component synthesis of spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] derivatives.
abstract: A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions.
authors: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China.
authors: Juxian
authors: J
authors: Wang
authors: Xiaoguang
authors: X
authors: Bai
authors: Changliang
authors: C
authors: Xu
authors: Yucheng
authors: Y
authors: Wang
authors: Wei
authors: W
authors: Lin
authors: Yi
authors: Y
authors: Zou
authors: Daqing
authors: D
authors: Shi
mesh_terms: D020650:Combinatorial Chemistry Techniques; D019220:High-Energy Shock Waves; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry; D013016:Sound; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D007211:Indoles; D010793:Phthalazines; D011720:Pyrazoles; D013141:Spiro Compounds; C057812:indoline; D007510:Isatin; C043388:phthalazine