title: Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment.
abstract: We evaluated immune and endocrine status following antituberculosis treatment in HIV-negative patients with newly diagnosed tuberculosis (TB). Treatment led to a decrease in IL-6, IL-1β, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after 4 months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after 4 months and started to decline after 6 months of treatment, reaching levels below those detected at inclusion. In contrast, in most patients, dehydroepiandrosterone sulfate (DHEAS) levels remained unchanged, although a trend toward increased concentrations was observed in a few cases 3 months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.
authors: Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Santa Fe, Argentina.
authors: Bettina
authors: B
authors: Bongiovanni
authors: Ariana
authors: A
authors: Díaz
authors: Luciano
authors: L
authors: D'Attilio
authors: Natalia
authors: N
authors: Santucci
authors: Griselda
authors: G
authors: Dídoli
authors: Susana
authors: S
authors: Lioi
authors: Luis J
authors: LJ
authors: Nannini
authors: Walter
authors: W
authors: Gardeñez
authors: Cristina
authors: C
authors: Bogue
authors: Hugo
authors: H
authors: Besedovsky
authors: Adriana
authors: A
authors: del Rey
authors: Oscar
authors: O
authors: Bottasso
authors: María Luisa
authors: ML
authors: Bay
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood*; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003687:Dehydroepiandrosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents; C508600:IL6 protein, human; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D002097:C-Reactive Protein; D006854:Hydrocortisone