title: [Effect of sub-anaesthetic doses of ketamine in the postoperative period in a patient with uncontrolled depression].
abstract: Recent studies indicate that the intravenous infusion of ketamine hydrochloride (an N-methyl-D-aspartate receptor antagonist) leads to a rapid reduction in depressive symptoms. A 42 year-old woman with breast cancer and major depression resistant to medical treatment received a 90 minute intravenous infusion of 0.3 mg/kg ketamine for 5 consecutive days. A significant reduction from 22 to 13 (-41%) was observed in the symptoms assessed using the Hamilton scale, with the effect maintained for 14 days. The possible therapeutic mechanism is discussed.
authors: Servicio de Anestesiología y Reanimación, Hospital Torrecárdenas, Almería, España. stl967523977@wanadoo.es
authors: M
authors: M
authors: Cortiñas-Saenz
authors: M B
authors: MB
authors: Alonso-Menoyo
authors: C L
authors: CL
authors: Errando-Oyonarte
authors: I
authors: I
authors: Alférez-García
authors: M A
authors: MA
authors: Carricondo-Martínez
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary / Q000628:therapy; D000700:Analgesics / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D004347:Drug Interactions; D004351:Drug Resistance; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008408:Mastectomy; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D010149:Postoperative Pain / Q000188:drug therapy*; D010864:Pilonidal Sinus / Q000601:surgery*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D000700:Analgesics; D000928:Antidepressive Agents; D018931:Antineoplastic Agents, Hormonal; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine