title: Do ADHD children with and without child behavior checklist-dysregulation profile have different clinical characteristics, cognitive features, and treatment outcomes?
abstract: OBJECTIVE
  The Child Behavior Checklist-Dysregulation Profile (CBCL-DP), characterized by elevated scores on the "Attention Problems," "Aggressive Behavior," and "Anxious/Depressed" scales in the CBCL, has been associated with later severe psychopathology. In a sample of children with ADHD, this study sought to further explore the clinical characteristics, the response to methylphenidate medication, and the cognitive features of ADHD children with CBCL-DP.
  
  
  METHODS
  The sample consisted of 173 ADHD outpatients (age = 10.9 ± 2.81) assessed using symptom severity scales, personality questionnaires (Emotionality Activity Sociability [EAS] and Junior Temperament and Character Inventory [JTCI]), and neuropsychological tests. A subsample of 136 participants was reassessed after optimal adjustment of methylphenidate dosage.
  
  
  CONCLUSIONS
  Variables that were independently associated with CBCL-DP were clinical severity (ADHD Rating Scale [ADHD-RS]), internalized disorders, high emotionality (EAS), and low self-directedness (JTCI). CBCL-DP was associated neither with poorer response to methylphenidate nor with more side effects. There were no differences in cognitive performances between participants with and without CBCL-DP.
authors: INSERM U669, University Paris-Sud and University Paris Descartes, Paris, France Robert Debré Hospital, Paris, France peyrehugo@yahoo.fr.
authors: Hugo
authors: H
authors: Peyre
authors: INSERM U669, University Paris-Sud and University Paris Descartes, Paris, France Versailles General Hospital. Le Chesnay, France University of Versailles Saint-Quentin-en-Yvelines, Versailles, France.
authors: Mario
authors: M
authors: Speranza
authors: University Hospital, Tours, France New York University Child Study Center, New York, USA INSERM U894, University Paris Descartes, Paris, France.
authors: Samuele
authors: S
authors: Cortese
authors: INSERM U894, University Paris Descartes, Paris, France Louis Mourier Hospital, Colombes, France.
authors: Mathias
authors: M
authors: Wohl
authors: Robert Debré Hospital, Paris, France INSERM U894, University Paris Descartes, Paris, France.
authors: Diane
authors: D
authors: Purper-Ouakil
mesh_terms: D000374:Aggression / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D057189:Checklist; D002648:Child; D002652:Child Behavior; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D012917:Social Adjustment; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D013694:Temperament; D016896:Treatment Outcome
chemical_list: D008774:Methylphenidate