title: An iodocyclization approach to substituted 3-iodothiophenes.
abstract: A novel approach to 3-iodothiophenes by direct iodocyclization of alkynylthiol derivatives is presented. A variety of 1-mercapto-3-yn-2-ols 5 (readily available from alkynylation of the corresponding alpha-mercapto ketones or alpha-mercapto esters) were smoothly converted into the corresponding 3-iodothiophene derivatives 6 in good yields by reaction with molecular iodine in the presence of NaHCO(3) at room temperature in MeCN as the solvent.
authors: Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Arcavacata di Rende (CS), Italy. b.gabriele@unical.it
authors: Bartolo
authors: B
authors: Gabriele
authors: Raffaella
authors: R
authors: Mancuso
authors: Giuseppe
authors: G
authors: Salerno
authors: Richard C
authors: RC
authors: Larock
mesh_terms: D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013438:Sulfhydryl Compounds; D013876:Thiophenes