title: One-pot synthesis of 2,4-disubstituted thiazoline from β-azido disulfide and carboxylic acid.
abstract: A concise and efficient one-pot four-step synthesis of 2,4-disubstituted thiazoline via a cascade disulfide bond cleavage/thiocarbonylation/Staudinger reduction/aza-Wittig reaction is established. Treatment of various carboxylic acids with β-azido disulfides under this one-pot procedure obtained the desired thiazolines in good to excellent isolated yields.
authors: School of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
authors: Yi
authors: Y
authors: Liu
authors: Jun
authors: J
authors: Liu
authors: Xiangbing
authors: X
authors: Qi
authors: Yuguo
authors: Y
authors: Du
mesh_terms: D001386:Azides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D053778:Thiazolidines / Q000138:chemical synthesis*
chemical_list: D001386:Azides; D002264:Carboxylic Acids; D004220:Disulfides; D053778:Thiazolidines