title: The role of androgen and androgen receptor in skin-related disorders.
abstract: Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris. Current treatments for these androgen/AR-involved diseases, which target the synthesis of androgens or prevent its binding to AR, can cause significant adverse side effects. Based on the recent studies using AR knockout mice, it has been suggested that AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases. Here, we review recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing.
authors: George Whipple Lab for Cancer Research, Departments of Pathology and Urology and The Wilmot Cancer Center, University of Rochester Medical Center, Box 626, URMC, 601 Elmwood Ave, Rochester, NY 14642, USA.
authors: Jiann-Jyh
authors: JJ
authors: Lai
authors: Philip
authors: P
authors: Chang
authors: Kuo-Pao
authors: KP
authors: Lai
authors: Lumin
authors: L
authors: Chen
authors: Chawnshang
authors: C
authors: Chang
mesh_terms: D000152:Acne Vulgaris / Q000378:metabolism* / Q000628:therapy; D000505:Alopecia / Q000378:metabolism* / Q000628:therapy; D000726:Androgen Antagonists / Q000627:therapeutic use; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D006628:Hirsutism / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000726:Androgen Antagonists; D000728:Androgens; D011944:Receptors, Androgen