title: New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine.
abstract: New adamantane derivatives with amino acid residues and other bifunctional compounds were synthesized and their antiviral activity towards influenza A(H1N1)pdm and A(H3N2) viruses was studied. Some of these adamantane derivatives completely suppressed replication of remantadine-resistant influenza A virus strains.
authors: D. I. Ivanovsky Institute of Virology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
authors: V A
authors: VA
authors: Shibnev
authors: T M
authors: TM
authors: Garaev
authors: M P
authors: MP
authors: Finogenova
authors: E S
authors: ES
authors: Shevchenko
authors: E I
authors: EI
authors: Burtseva
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects*; D012299:Rimantadine / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D012299:Rimantadine; D000218:Adamantane