title: SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.
abstract: SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.
authors: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
authors: Elaine A
authors: EA
authors: Hong
authors: Hannah L
authors: HL
authors: Gautrey
authors: David J
authors: DJ
authors: Elliott
authors: Alison J
authors: AJ
authors: Tyson-Capper
mesh_terms: D000818:Animals; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D034521:Nuclear Matrix-Associated Proteins / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D036961:Matrix Attachment Region Binding Proteins; D034521:Nuclear Matrix-Associated Proteins; D011960:Receptors, Estrogen; C109132:SAFB protein, human; C486369:SAFB2 protein, human