title: Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta.
abstract: OBJECTIVE
  The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD).
  
  
  METHODS
  Fifteen fresh porcine aortas were harvested and preserved with 4 °C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy.
  
  
  RESULTS
  The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling.
  
  
  CONCLUSIONS
  Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD.
authors: Division of Vascular Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
authors: K-X
authors: KX
authors: Qing
authors: Y C
authors: YC
authors: Chan
authors: S F
authors: SF
authors: Lau
authors: W-K
authors: WK
authors: Yiu
authors: A C W
authors: AC
authors: Ting
authors: S W K
authors: SW
authors: Cheng
mesh_terms: D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology*; D013552:Swine; D018608:Ultrasonography, Doppler / Q000379:methods*