title: The ε4 allele of the APOE gene is associated with more severe peripheral neuropathy in type 2 diabetic patients.
abstract: We examined the association between the ε4 allele of the apolipoprotein E gene and severity of peripheral neuropathy in 234 patients with type 2 diabetes mellitus (T2DM). Based on the Neuropathy Disability Score (NDS), patients were divided into group A (NDS ≤ 6: mild or no neuropathy) and group B (NDS > 6: severe neuropathy). In each group, patients were further divided into ε4 carriers and non-ε4 carriers. In multivariate analysis, a more than 5-fold increased risk of severe neuropathy was associated with ε4 carrier status (adjusted odds ratio [aOR]: 5.26, 95% confidence interval [CI]: 2.24-12.31, P = .0001). The other significant risk factors for severe neuropathy included male gender (aOR: 2.08, 95% CI: 1.05-4.14, P = .036), diabetes duration (aOR: 1.05, 95% CI: 1.00-1.09, P = .039), and hemoglobin A1c (aOR: 1.32, 95% CI: 1.05-1.66, P = .020). In conclusion, the ε4 carrier status appears to be associated with severe peripheral neuropathy in T2DM.
authors: Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Greece. c_monastiriotis@yahoo.com
authors: C
authors: C
authors: Monastiriotis
authors: N
authors: N
authors: Papanas
authors: G
authors: G
authors: Trypsianis
authors: K
authors: K
authors: Karanikola
authors: S
authors: S
authors: Veletza
authors: E
authors: E
authors: Maltezos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000235:genetics*; D004185:Disability Evaluation; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human