title: Glyoxalase I (GLO1) is up-regulated in pancreatic cancerous tissues compared with related non-cancerous tissues.
abstract: BACKGROUND
  Glyoxalase I (GLO1), an enzyme involved in the detoxification of methylglyoxal in the glycolysis pathway, has been found to be frequently overexpressed in various types of cancer. Recent studies showed that GLO1 is related to proliferation and apoptosis in human cancer cells. However, expression of GLO1 in pancreatic cancer (PC) has not been precisely defined. Since PC is one of the most malignant types of cancer, we investigated the levels of GLO1 in tissues from patients with PC.
  
  
  METHODS
  We examined the expression of GLO1 in tumors from patients with PC and adjacent normal tissues by western blotting.
  
  
  RESULTS
  Western blotting demonstrated that GLO1 was significantly overexpressed in pancreatic cancerous tissues compared with adjacent non-cancerous tissues (n=20, p<0.05).
  
  
  CONCLUSIONS
  GLO1 could be a clinically useful target in the therapy of PC.
authors: Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
authors: Yufeng
authors: Y
authors: Wang
authors: Yasuhiro
authors: Y
authors: Kuramitsu
authors: Tomio
authors: T
authors: Ueno
authors: Nobuaki
authors: N
authors: Suzuki
authors: Shigefumi
authors: S
authors: Yoshino
authors: Norio
authors: N
authors: Iizuka
authors: Junko
authors: J
authors: Akada
authors: Takao
authors: T
authors: Kitagawa
authors: Masaaki
authors: M
authors: Oka
authors: Kazuyuki
authors: K
authors: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D015153:Blotting, Western; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000201:enzymology*; D015854:Up-Regulation
chemical_list: D007791:Lactoylglutathione Lyase