title: Osseointegration assessment of chairside argon-based nonthermal plasma-treated Ca-P coated dental implants.
abstract: This study investigated the effect of an Argon-based nonthermal plasma (NTP) surface treatment-operated chairside at atmospheric pressure conditions applied immediately prior to dental implant placement in a canine model. Surfaces investigated comprised: Calcium-Phosphate (CaP) and CaP + NTP (CaP-Plasma). Surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and chemistry by X-ray photoelectron spectroscopy (XPS). Six adult beagles dogs received 2 plateau-root form implants (n = 1 each surface) in each radii, providing implants that remained 1 and 3 weeks in vivo. Histometric parameters assessed were bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed by Kruskall-Wallis (95% level of significance) and Dunn's post-hoc test. The XPS analysis showed peaks of Ca, C, O, and P for the CaP and CaP-Plasma surfaces. Both surfaces presented carbon primarily as hydrocarbon (C-C, C-H) with lower levels of oxidized carbon forms. The CaP surface presented atomic percent values of 38, 42, 11, and 7 for C, O, Ca, and P, respectively, and the CaP-Plasma presented increases in O, Ca, and P atomic percent levels at 53, 12, and 13, respectively, in addition to a decrease in C content at 18 atomic percent. At 1 week no difference was found in histometric parameters between groups. At 3 weeks significantly higher BIC and BAFO were observed for CaP-Plasma treated surfaces. Surface elemental chemistry was modified by the Ar-based NTP. Ar-based NTP improved bone formation around plateau-root form implants at 3 weeks compared with CaP treatment alone.
authors: Department of Oral Diagnosis and Surgery, Araraquara Dental School, UNESP-Universidade Estadual Paulista, Araraquara, SP, Brazil.
authors: Gabriela
authors: G
authors: Giro
authors: Nick
authors: N
authors: Tovar
authors: Lukasz
authors: L
authors: Witek
authors: Charles
authors: C
authors: Marin
authors: Nelson R F
authors: NR
authors: Silva
authors: Estevam A
authors: EA
authors: Bonfante
authors: Paulo G
authors: PG
authors: Coelho
mesh_terms: D000818:Animals; D001128:Argon / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D015921:Dental Implants; D004285:Dogs; D020007:Implants, Experimental; D008297:Male; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D058626:Plasma Gases / Q000494:pharmacology*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D058626:Plasma Gases; D001128:Argon; C020243:calcium phosphate