title: The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa.
abstract: PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation.
authors: BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: M
authors: M
authors: Mac Aogáin
authors: BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: M J
authors: MJ
authors: Mooij
authors: BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: R R
authors: RR
authors: McCarthy
authors: BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: E
authors: E
authors: Plower
authors: National Laboratory of Plant Engineering and Protein Genetic Engineering, College of Life Science, Peking University, Beijing, PR China.
authors: Y P
authors: YP
authors: Wang
authors: National Laboratory of Plant Engineering and Protein Genetic Engineering, College of Life Science, Peking University, Beijing, PR China.|BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: Z X
authors: ZX
authors: Tian
authors: Department of Microbiology, University College Cork, Cork, Ireland.|Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland.
authors: A
authors: A
authors: Dobson
authors: Department of Microbiology, University College Cork, Cork, Ireland.|Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland.
authors: J
authors: J
authors: Morrissey
authors: BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: C
authors: C
authors: Adams
authors: Department of Microbiology, University College Cork, Cork, Ireland.|Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland.|BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.
authors: F
authors: F
authors: O'Gara
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008670:Metals / Q000378:metabolism / Q000494:pharmacology; D008969:Molecular Sequence Data; D009876:Operon; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017384:Sequence Deletion; D015534:Trans-Activators; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D008670:Metals; D012097:Repressor Proteins; D015534:Trans-Activators