title: Horses for courses: a DNA-based test for race distance aptitude in thoroughbred racehorses.
abstract: Variation at the myostatin (MSTN) gene locus has been shown to influence racing phenotypes in Thoroughbred horses, and in particular, early skeletal muscle development and the aptitude for racing at short distances. Specifically, a single nucleotide polymorphism (SNP) in the first intron of MSTN (g.66493737C/T) is highly predictive of best race distance among Flat racing Thoroughbreds: homozygous C/C horses are best suited to short distance races, heterozygous C/T horses are best suited to middle distance races, and homozygous T/T horses are best suited to longer distance races. Patent applications for this gene marker association, and other linked markers, have been filed. The information contained within the patent applications is exclusively licensed to the commercial biotechnology company Equinome Ltd, which provides a DNA-based test to the international Thoroughbred horse racing and breeding industry. The application of this information in the industry enables informed decision making in breeding and racing and can be used to assist selection to accelerate the rate of change of genetic types among distinct populations (Case Study 1) and within individual breeding operations (Case Study 2).
authors: UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin, Ireland. Emmeline.Hill@ucd.ie
authors: Emmeline W
authors: EW
authors: Hill
authors: Donal P
authors: DP
authors: Ryan
authors: David E
authors: DE
authors: MacHugh
mesh_terms: D000818:Animals; D001076:Aptitude; D001947:Breeding / Q000379:methods; D004247:DNA / Q000032:analysis* / Q000235:genetics; D003657:Decision Making; D005819:Genetic Markers; D006579:Heterozygote; D006720:Homozygote; D006736:Horses / Q000235:genetics* / Q000502:physiology; D055435:Myostatin / Q000235:genetics*; D010330:Patents as Topic; D010641:Phenotype; D010805:Physical Conditioning, Animal; D020641:Polymorphism, Single Nucleotide; D012420:Running; D013045:Species Specificity
chemical_list: D005819:Genetic Markers; D055435:Myostatin; D004247:DNA