title: Prognostic impact of diabetes mellitus and hypertension for mid-term outcome of patients with acute myocardial infarction who underwent percutaneous coronary intervention.
abstract: BACKGROUND
  The synergistic effect of diabetes mellitus (DM) and hypertension on mid-term outcome among acute myocardial infarction (MI) patients undergoing percutaneous coronary intervention (PCI) is still controversial.
  
  
  METHODS
  A total of 2438 patients with acute MI who underwent PCI from January 2007 to November 2010 were studied. Patients were stratified to four groups according to the presence of DM or hypertension and followed up during 12 months. We analyzed the influence of hypertension and DM on major adverse cardiac events (MACE: death, recurrent MI, repeated coronary artery revascularization).
  
  
  RESULTS
  No history of hypertension or DM was found in 35.0%, a history of hypertension in 27.2%, a history of DM in 15.0%, and a history of both disease entities in 22.8%. The rate of MACE was significantly higher in hypertensive DM group (15.9% vs. 22.9% vs. 28.8% vs. 37.0%, log-rank p<0.001). In multivariate analysis, hypertension and DM were meaningful predictors of mid-term mortality, and the combination of the two was a stronger predictor (hazard ratio=1.790; 95% confidence interval=1.313-2.442; p<0.001).
  
  
  CONCLUSIONS
  After PCI, acute MI patients with a history of DM or hypertension had a higher mid-term mortality than acute MI patients without such a history. The combination of DM and hypertension appeared to be more strongly associated with mortality than DM or hypertension alone.
authors: Heart Research Center of Chonnam National University Hospital, Gwangju, Republic of Korea.
authors: Min Goo
authors: MG
authors: Lee
authors: Myung Ho
authors: MH
authors: Jeong
authors: Ki Hong
authors: KH
authors: Lee
authors: Keun Ho
authors: KH
authors: Park
authors: Doo Sun
authors: DS
authors: Sim
authors: Hyun Ju
authors: HJ
authors: Yoon
authors: Nam Sik
authors: NS
authors: Yoon
authors: Kye Hun
authors: KH
authors: Kim
authors: Hyung Wook
authors: HW
authors: Park
authors: Young Joon
authors: YJ
authors: Hong
authors: Ju Han
authors: JH
authors: Kim
authors: Youngkeun
authors: Y
authors: Ahn
authors: Jeong Gwan
authors: JG
authors: Cho
authors: Jong Chun
authors: JC
authors: Park
authors: Jung Chaee
authors: JC
authors: Kang
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D016896:Treatment Outcome