title: Novel one-pot three-component coupling reaction with trimethylsilylmethyl-phosphonate, acyl fluoride, and aldehyde through the Horner-Wadsworth-Emmons reaction.
abstract: A novel three-component coupling between trimethylsilylmethylphosphonate, acyl fluoride, and aldehyde has been developed. A sequential nucleophilic addition of lithio-trimethylsilylmethylphosphonate to the acyl fluoride and Horner-Wadsworth-Emmons reaction of an aldehyde with the lithio-β-ketophosphonate generated in situ by desilylation at the α-position of the α-silyl-β-ketophosphonate by fluoride took place cleanly in a one-pot operation. Various E- and Z-enones were obtained in high yields with high stereoselectivities by this one-pot procedure.
authors: Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan. umezawa@ees.hokudai.ac.jp
authors: Taiki
authors: T
authors: Umezawa
authors: Tomoya
authors: T
authors: Seino
authors: Fuyuhiko
authors: F
authors: Matsuda