title: The role of induced pluripotent stem cells in research and therapy of primary immunodeficiencies.
abstract: The advent of reprogramming technology has greatly advanced the field of stem cell biology and nurtured our hope to create patient specific renewable stem cell sources. While the number of reports of disease specific induced pluripotent stem cells is continuously rising, the field becomes increasingly more aware that induced pluripotent stem cells are not as similar to embryonic stem cells as initially assumed. Our state of the art understanding of human induced pluripotent stem cells, their capacity, their limitations and their promise as it pertains to the study and treatment of primary immunodeficiencies, is the content of this review.
authors: Division of Hematology/Oncology, Children's Hospital Boston, Boston, USA.
authors: Katja G
authors: KG
authors: Weinacht
authors: Patrick M
authors: PM
authors: Brauer
authors: Kerstin
authors: K
authors: Felgentreff
authors: Alex
authors: A
authors: Devine
authors: Andrew R
authors: AR
authors: Gennery
authors: Silvia
authors: S
authors: Giliani
authors: Waleed
authors: W
authors: Al-Herz
authors: Axel
authors: A
authors: Schambach
authors: Juan Carlos
authors: JC
authors: Zúñiga-Pflücker
authors: Luigi D
authors: LD
authors: Notarangelo
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D017690:Cell Transplantation / Q000379:methods / Q000639:trends; D004195:Disease Models, Animal; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000473:pathology / Q000502:physiology* / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends