title: Hyperlipidaemia in trypanosomiasis of naturally infected horses: possible cachexia-anorexia syndrome?
abstract: Trypanosomiasis caused by Trypanosoma evansi commonly produces wasting disease with signs of emaciation and cachexia mainly at the end stage. The present study was conducted to explore the possible hyperlipaemia or hyperlipidaemia and its association with cachexia-anorexia in equine trypanosomiasis. Out of the fifteen confirmed animals, none of the plasma sample was opaque. There was a significant increase in plasma triglyceride, total cholesterol and blood urea nitrogen and a highly significant increase in low-density lipoprotein (LDL) levels. A mild increase in high-density lipoprotein (HDL) and very low-density lipoprotein levels were observed, while the relative percentage of HDL and LDL was altered with high significance. A moderate increase in triglyceride and highly significant increase in LDL might be the reasons for retention of appetite and lipolysis. Possible protein breakdown and presence of lipolysis might be the reasons for cachexia in equine trypanosomiasis.
authors: Division of Medicine, Indian Veterinary Research Institute, Izatnagar, 243122, India.
authors: Muthusamy
authors: M
authors: Ranjithkumar
authors: Tauseef Ahmed
authors: TA
authors: Malik
authors: Anju
authors: A
authors: Saxena
authors: Ananya
authors: A
authors: Dan
authors: Pillanatham Civalingam
authors: PC
authors: Sakthivel
authors: Sahadeb
authors: S
authors: Dey
mesh_terms: D000818:Animals; D000855:Anorexia / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D001066:Appetite; D001806:Blood Urea Nitrogen; D002100:Cachexia / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D006734:Horse Diseases / Q000469:parasitology / Q000503:physiopathology*; D006736:Horses; D006949:Hyperlipidemias / Q000469:parasitology / Q000503:physiopathology / Q000662:veterinary*; D008055:Lipids / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet / Q000662:veterinary; D014345:Trypanosoma / Q000502:physiology; D014352:Trypanosomiasis / Q000150:complications / Q000469:parasitology / Q000662:veterinary*
chemical_list: D008055:Lipids