title: Hematological alterations during experimental canine infection by Trypanosoma cruzi.
abstract: To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.
authors: Department of Microbiology and Parasitology, Health Science Center, Federal University of Rio Grande do Norte, Av. Salgado Filho s/n, Rio Grande do Norte, RN, Brazil. pauloguedes@cb.ufrn.br
authors: Paulo Marcos Matta
authors: PM
authors: Guedes
authors: Vanja Maria
authors: VM
authors: Veloso
authors: Tiago Wilson Patriarca
authors: TW
authors: Mineo
authors: Juliana
authors: J
authors: Santiago-Silva
authors: Geovan
authors: G
authors: Crepalde
authors: Ivo Santana
authors: IS
authors: Caldas
authors: Manuela Sales Lima
authors: MS
authors: Nascimento
authors: Marta
authors: M
authors: Lana
authors: Egler
authors: E
authors: Chiari
authors: Lúcia Maria da Cunha
authors: LM
authors: Galvão
authors: Maria Terezinha
authors: MT
authors: Bahia
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000150:complications*; D004195:Disease Models, Animal; D004285:Dogs; D006402:Hematologic Diseases / Q000209:etiology*