title: Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy.
abstract: It is now well established that hyperglycemia, present in both type 1 and type 2 diabetes, causes a variety of biochemical derangements leading to a diffused vascular damage responsible for several pathologic manifestations. Although preclinical and clinical studies have been performed by an unreliable administration route, the correct approach of oxygen-ozonetherapy may break a vicious circle. Messengers, released by a precise interaction ex vivo of the patient's blood with an equivalent calculated dose of ozone (0.42-0.84 mM), react with a variety of cells after blood infusion and restore a number of functions went astray. This paper aims to open a debate on this new therapy for improving the prognosis of diabetes.
authors: Department of Physiology, University of Siena, Via A. Moro 2, 53100 Siena, Italy. bocci@unisi.it
authors: Velio
authors: V
authors: Bocci
authors: Iacopo
authors: I
authors: Zanardi
authors: Maya S P
authors: MS
authors: Huijberts
authors: Valter
authors: V
authors: Travagli
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D010102:Oxygen Inhalation Therapy / Q000379:methods / Q000639:trends; D010126:Ozone / Q000627:therapeutic use*
chemical_list: D010126:Ozone