title: Inflammatory marker sTREM-1 reflects the clinical stage and respiratory tract obstruction in allergic asthma bronchiale patients and correlates with number of neutrophils.
abstract: The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes. The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of 76 patients with allergic asthma bronchiale and 39 healthy controls. Our results revealed more than 3.5 times higher levels of sTREM-1 in AB patients (92.3 pg/mL ± 125.6) compared with healthy subjects (25.7 pg/mL ± 9.2; P = 0.0001). Higher levels of sTREM-1 were found also in patients with exacerbated AB (170.5 pg/mL ± 78.2) compared with nonexacerbated AB patients (59.1 ± 78.2; P < 0.0001), patients with respiratory tract obstruction (176.4 pg/mL ± 177.8), than those without obstruction (51.99 pg/mL ± 64.0; P < 0.0001) and patients with anti-IgE therapy (P < 0.0001). Levels of sTREM-1 correlated with number of leucocytes (P = 0.002), and absolute number of neutrophils (P = 0.001). Elevated plasma levels of sTREM-1 reflect the severity, state of exacerbation, presence of respiratory tract obstruction in AB patients and together with increased number of neutrophils point to the role of neutrophils in inflammation accompanying AB.
authors: Institute of Immunology, Comenius University, Bratislava, Slovakia. maria.bucova@gmail.com
authors: Maria
authors: M
authors: Bucova
authors: Magda
authors: M
authors: Suchankova
authors: Martin
authors: M
authors: Dzurilla
authors: Mojmir
authors: M
authors: Vrlik
authors: Helena
authors: H
authors: Novosadova
authors: Eva
authors: E
authors: Tedlova
authors: Stefan
authors: S
authors: Urban
authors: Edita
authors: E
authors: Hornakova
authors: Marianna
authors: M
authors: Seligova
authors: Vladimira
authors: V
authors: Durmanova
authors: Peter
authors: P
authors: Penz
authors: Juraj
authors: J
authors: Javor
authors: Ema
authors: E
authors: Paulovicova
mesh_terms: D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000097:blood*; D001249:Asthma; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1