title: Glasgow Prognostic Score as a useful prognostic factor after hepatectomy for hepatocellular carcinoma.
abstract: BACKGROUND
  Several previous studies have revealed that the Glasgow Prognostic Score (GPS) is a clinically useful scoring system to predict the prognosis of patients with various kinds of advanced cancers. However, there have been few reports on the relationship between the GPS and prognosis after hepatectomy for hepatocellular carcinoma (HCC). Therefore, we performed an analysis of the relationship between the GPS and prognosis after hepatectomy for HCC.
  
  
  METHODS
  Between January 2005 and December 2009, 352 HCC patients underwent hepatectomy at Kumamoto University Hospital. Nineteen clinicopathologic factors were analyzed, using univariate and multivariate analyses.
  
  
  RESULTS
  Univariate analysis showed that significant risk factors for poor survival included serum albumin level (<3.5 g/dL), tumor size (>35 mm), presence of ascites, portal vein invasion, operation time (>400 min), blood loss (>360 mL), requirement for blood transfusion, and GPS. Multivariate analysis revealed that tumor size [hazard ratio (HR) 3.355; p = 0.003], operation time (HR 2.634; p = 0.006), portal vein invasion (HR 2.419; p = 0.009), and GPS (HR 3.796; p < 0.001) were independent factors for poor prognosis.
  
  
  CONCLUSIONS
  The GPS was demonstrated to be a statistically significant prognostic factor after hepatectomy for HCC.
authors: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan, horino@tamana-chp.jp.
authors: Kei
authors: K
authors: Horino
authors: Toru
authors: T
authors: Beppu
authors: Hideyuki
authors: H
authors: Kuroki
authors: Kosuke
authors: K
authors: Mima
authors: Hirohisa
authors: H
authors: Okabe
authors: Osamu
authors: O
authors: Nakahara
authors: Yoshiaki
authors: Y
authors: Ikuta
authors: Akira
authors: A
authors: Chikamoto
authors: Takatoshi
authors: T
authors: Ishiko
authors: Hiroshi
authors: H
authors: Takamori
authors: Hideo
authors: H
authors: Baba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011169:Portal Vein / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome