title: Serum HCG measured in the peri-implantation period predicts IVF cycle outcomes.
abstract: The current study assessed the relationship between serum concentrations of human chorionic gonadotrophin (HCG) measured in the peri-implantation period and various outcome measures following blastocyst transfer in IVF cycles. The study group included 767 autologous IVF cycles, each with the transfer of two fresh blastocysts in a 6-year study period, ending 31 December 2009. Outcome measures were ectopic pregnancy, biochemical pregnancy loss, ongoing pregnancy, spontaneous abortion and multiple pregnancy. Peri-implantation serum HCG concentration measured 5 days after blastocyst transfer was highly predictive of these outcome measures. These findings suggest embryonic implantation and developmental fate are largely determined by 5 days after blastocyst transfer and that very early serum HCG measurements may be useful markers of IVF outcome.
authors: Fertility Center of Las Vegas, 8851 W. Sahara Avenue, Las Vegas, NV 89117, USA. bsshapiro@aol.com
authors: Bruce S
authors: BS
authors: Shapiro
authors: Said T
authors: ST
authors: Daneshmand
authors: Humberto
authors: H
authors: Restrepo
authors: Forest C
authors: FC
authors: Garner
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001755:Blastocyst / Q000166:cytology; D006063:Chorionic Gonadotropin / Q000097:blood*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007246:Infertility / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D011271:Pregnancy, Ectopic / Q000209:etiology; D011272:Pregnancy, Multiple; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D006063:Chorionic Gonadotropin