title: Role of thoracotomy and metastatectomy in gestational trophoblastic neoplasia: a single center experience.
abstract: Gestational trophoblastic neoplasia (GTN) is a rare collection of malignancies which are usually curable with modern chemotherapy. Lung metastasis is a relatively common feature of these malignancies and is not considered an adverse prognostic feature. Occasionally, however, the management of these patients necessitates adjuvant thoracic surgery, either to establish the diagnosis or to potentially provide a curative resection of drug-resistant foci of disease. This case series highlights 5 such cases in which thoracic surgery has significantly contributed to the management and outcome of complicated GTN patients, and suggests when thoracic surgery should be considered in this rare group of patients.
authors: Gestational Trophoblastic Disease Centre and the Departments of Thoracic Surgery and of Medical Oncology, Imperial College NHS Healthcare Trust, London, U.K.
authors: Constantine
authors: C
authors: Alifrangis
authors: Michelle J
authors: MJ
authors: Wilkinson
authors: Demetrios C
authors: DC
authors: Stefanou
authors: Jagdeep S
authors: JS
authors: Virk
authors: Jon
authors: J
authors: Anderson
authors: Michael J
authors: MJ
authors: Seckl
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000235:genetics / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D007044:Hysterectomy; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000556:secondary / Q000628:therapy*; D008197:Lymph Node Excision; D018895:Microsatellite Repeats; D011247:Pregnancy; D016634:Radiosurgery; D012074:Remission Induction; D033581:Stem Cell Transplantation; D013908:Thoracotomy; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin