title: A panoramic view to relationships between reproductive failure and immunological factors.
abstract: OBJECTIVE
  To examine the possible roles of various immunological factors in recurrent miscarriage and unexplained infertility.
  
  
  METHODS
  The synthesis and review of the relevant current literature in English language.
  
  
  RESULTS
  Substantial evidence suggests that antiphospholipid antibodies, lupus anticoagulant, antisperm antibodies, antithyroid antibodies, anti-endometrial antibodies, antiovarian antibodies, anti-C trachomatis antibodies, cytokines, and immunological events in endometriosis and premature ovarian failure due to immunologic factors may contribute to reproductive failure including unexplained infertility and/or non-chromosomal recurrent miscarriage.
  
  
  CONCLUSIONS
  Elimination or suppression of the immunological factors related with reproductive failure might occupy an important place in the treatment of unexplained infertility and non-chromosomal recurrent miscarriage.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis, Kurupelit, 55139 Samsun, Turkey. arifkokcu@yahoo.com
authors: Arif
authors: A
authors: Kokcu
authors: Erhan
authors: E
authors: Yavuz
authors: Handan
authors: H
authors: Celik
authors: Devran
authors: D
authors: Bildircin
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D010064:Embryo Implantation / Q000276:immunology; D004715:Endometriosis / Q000276:immunology; D005187:Fallopian Tubes / Q000276:immunology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D007248:Infertility, Male / Q000276:immunology*; D008297:Male; D016649:Primary Ovarian Insufficiency / Q000276:immunology; D013084:Sperm-Ovum Interactions / Q000276:immunology