title: Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1].
abstract: Antiproliferative bioassay-guided fractionation of the ethanol extract of the endemic Malagasy Rubiaceous plant Tarenna grevei led to the isolation of two new antiproliferative oxygenated oleanane triterpene saponins. The structures of the two active compounds were elucidated as 23-hydroxylongispinogenin 3-O-beta-D-glucopyranoside (1) and longispinogenin 3-O-beta-D-glucopyranosyl (1 --> 2)-beta-D-glucopyranoside (3) by analyses of their spectral data including 1D- and 2D-NMR spectroscopy and chemical evidence. Compounds 1 and 3 displayed moderate antiproliferative activity against the A2780 ovarian cancer cell line with IC50 values of 7.6 and 4 microM, respectively.
authors: Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061-0212, USA.
authors: Liva
authors: L
authors: Harinantenaina
authors: Peggy J
authors: PJ
authors: Brodie
authors: Martin W
authors: MW
authors: Callmander
authors: L Jérémie
authors: LJ
authors: Razafitsalama
authors: Vincent E
authors: VE
authors: Rasamison
authors: Etienne
authors: E
authors: Rakotobe
authors: David G I
authors: DG
authors: Kingston
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D014197:Trees
chemical_list: D012503:Saponins