title: Plasmodium vivax malaria admissions and risk of mortality in a tertiary-care children's hospital in North India.
abstract: BACKGROUND
  In 2010, there was an increase in the severity of malaria admissions to Kalawati Saran Children's Hospital, New Delhi and this report describes the morbidity and mortality profile.
  
  
  METHODS
  A retrospective chart review of patients admitted with parasitologically confirmed malaria between January and December 2010.
  
  
  RESULTS
  There were 156 cases: P. vivax 105 (67.3%), P. falciparum 39 (25%) and mixed infections 12 (7.7%). Thrombocytopenia (platelet count <150×10(9)/L) was present in 90 (85.7%) patients with P. vivax mono-infection. There were 91 (58.3%) patients with severe malaria: P. vivax mono-infection 46 (50.5%), P. falciparum mono-infection 35 (38.5%) and mixed 10 (11%). Severe anaemia and severe thrombocytopenia (platelet count <20×10(9)/L) were detected significantly more often in P. falciparum and P. vivax mono-infection, respectively. Complications including cerebral malaria, acute renal failure, shock, acute respiratory distress syndrome (ARDS) and multiple-organ dysfunction syndrome (MODS) were similar in both groups. The mortality rate of around 20% was similar in severe P. vivax and P. falciparum mono-infection. Risk of mortality in vivax malaria was highest in patients with ARDS followed by MODS and shock.
  
  
  CONCLUSIONS
  Increased morbidity owing to P. vivax malaria was observed and risk of mortality was highest in patients with ARDS and MODS.
authors: Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India. drrajnisharma@yahoo.com
authors: Rajni
authors: R
authors: Sharma
authors: Suraj
authors: S
authors: Gohain
authors: Jagdish
authors: J
authors: Chandra
authors: Virendra
authors: V
authors: Kumar
authors: Abhishek
authors: A
authors: Chopra
authors: Sayan
authors: S
authors: Chatterjee
authors: Satinder
authors: S
authors: Aneja
authors: Ashok Kumar
authors: AK
authors: Dutta
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000453:epidemiology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D016778:Malaria, Falciparum / Q000150:complications / Q000453:epidemiology* / Q000401:mortality* / Q000473:pathology; D016780:Malaria, Vivax / Q000150:complications / Q000453:epidemiology* / Q000401:mortality* / Q000473:pathology; D008297:Male; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D012307:Risk Factors; D016019:Survival Analysis; D062606:Tertiary Care Centers; D013921:Thrombocytopenia / Q000453:epidemiology / Q000473:pathology