title: High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients.
abstract: OBJECTIVE
  We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.
  
  
  METHODS
  SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.
  
  
  RESULTS
  sUA among survivors (112.1 ± 13.82 μmol/L) was significantly lower than in deceased (160.8 ± 16.81 μmol/L, p < 0.001), while SOD was higher in survivors (31.8 ± 6.61 kU/L) than among deceased (20.2 ± 3.03, p < 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (≥ 127.11 μmol/L, p < 0.001), and for SOD in the lowest tertile (≤ 23.83 kU/L, p < 0.05).
  
  
  CONCLUSIONS
  Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
authors: Center for Clinical Laboratory Diagnostics, Clinical Center of Montenegro, Podgorica, Montenegro.
authors: Tanja
authors: T
authors: Antunovic
authors: Aleksandra
authors: A
authors: Stefanovic
authors: Marina
authors: M
authors: Ratkovic
authors: Branka
authors: B
authors: Gledovic
authors: Najdana
authors: N
authors: Gligorovic-Barhanovic
authors: Dragica
authors: D
authors: Bozovic
authors: Jasmina
authors: J
authors: Ivanisevic
authors: Milica
authors: M
authors: Prostran
authors: Marina
authors: M
authors: Stojanov
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality* / Q000503:physiopathology; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000401:mortality*; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000097:blood*; D016019:Survival Analysis; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D008315:Malondialdehyde; D013482:Superoxide Dismutase