title: The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.
abstract: Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.
authors: Institut für Zoologie III-Neurobiologie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany.
authors: Sara
authors: S
authors: Kuntz
authors: Burkhard
authors: B
authors: Poeck
authors: Marla B
authors: MB
authors: Sokolowski
authors: Roland
authors: R
authors: Strauss
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000166:cytology*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D010775:Photic Stimulation; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D018709:Statistics, Nonparametric
chemical_list: D029721:Drosophila Proteins; D049452:Green Fluorescent Proteins; D038744:Ribosomal Protein S6 Kinases, 90-kDa; C069330:ribosomal protein S6 kinase, 90kDa, polypeptide 3; D017869:Cyclic GMP-Dependent Protein Kinases; C528566:for protein, Drosophila