title: Isolation, characterization, and NO inhibitory activities of sesquiterpenes from Blumea balsamifera.
abstract: Blumea balsamifera  belongs to the family Compositae, and its leaves have been used as a flavoring ingredient and a tea. A phytochemical investigation of the aerial parts of  B. balsamifera  led to the isolation of 10 new (1-10) and 1 known (11) sesquiterpenes. Their structures were elucidated on the basis of extensive one- and two-dimensional nuclear magnetic resonance (heteronuclear multiple-quantum coherence, heteronuclear multiple-bond correlation, (1)H-(1)H correlation spectroscopy, and nuclear Overhauser effect spectrometry) spectroscopic data analyses, and the structure of compound 1 was confirmed by X-ray crystallography. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these sesquiterpenes were evaluated, and all of the compounds showed inhibitory effects.
authors: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China.
authors: Jing
authors: J
authors: Xu
authors: Da-qing
authors: DQ
authors: Jin
authors: Cuizhou
authors: C
authors: Liu
authors: Chunfeng
authors: C
authors: Xie
authors: Yuanqiang
authors: Y
authors: Guo
authors: Lingzhi
authors: L
authors: Fang
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002460:Cell Line; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D017628:Microglia; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D012717:Sesquiterpenes; D009569:Nitric Oxide