title: Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism.
abstract: BACKGROUND
  The heart was very sensitive to fluctuating thyroid hormone levels. To assess intra-left ventricular (LV) systolic asynchrony in patients with subclinical thyroid dysfunction.
  
  
  METHODS
  Fifty patients with subclinical hypothyroidism and 40 controls were included. A diagnosis of subclinical hypothyroidism was reached with increased TSH and normal free T4. All subjects were evaluated by echocardiography. Evaluation of intra-LV systolic asynchrony was performed by tissue synchronization imaging (TSI), and four TSI parameters of systolic asynchrony were calculated. LV asynchrony was defined by these parameters.
  
  
  RESULTS
  All of the groups were similar in terms of demographic findings and conventional and Doppler echocardiograpic parameters except peak systolic velocity and early diastolic velocity. LV systolic asynchrony parameters of TSI including; standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any 2 of the 12 LV segments (Ts-12), standard deviation of TS of the 6 basal LV segments (Ts-SD-6), maximal difference in Ts between any of the 6 basal LV segments (Ts-6) were significantly lengthened in patients with subclinical hypothyroidism than controls (p <0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). The prevalence of LV asynchrony was significantly higher in patients with subclinical hypothyroidism than control.
  
  
  CONCLUSIONS
  Patients with subclinical hypothyroidism present evidence of LV asynchrony by TSI. LV systolic asynchrony could be a warning sign of the early stage in cardiac systolic dysfunction in subclinical hypothyroid patients.
authors: Department of Cardiology, Faculty of Medicine, Abant Izzet Baysal University, Turkey. drserkan69@hotmail.com
authors: Serkan
authors: S
authors: Ozturk
authors: Aytekin
authors: A
authors: Alcelik
authors: Mehmet
authors: M
authors: Ozyasar
authors: Oguz
authors: O
authors: Dikbas
authors: Selim
authors: S
authors: Ayhan
authors: Fatih
authors: F
authors: Ozlu
authors: Alim
authors: A
authors: Erdem
authors: Mehmet
authors: M
authors: Tosun
authors: Davut
authors: D
authors: Baltaci
authors: Mehmet
authors: M
authors: Yazici
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D013599:Systole; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D013972:Thyrotropin; D013974:Thyroxine