title: Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN.
abstract: Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m(2)). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.
authors: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
authors: Wei
authors: W
authors: Zhao
authors: Nathan E
authors: NE
authors: Wineinger
authors: Hemant K
authors: HK
authors: Tiwari
authors: Thomas H
authors: TH
authors: Mosley
authors: Ulrich
authors: U
authors: Broeckel
authors: Donna K
authors: DK
authors: Arnett
authors: Sharon L R
authors: SL
authors: Kardia
authors: Edmond K
authors: EK
authors: Kabagambe
authors: Yan V
authors: YV
authors: Sun
mesh_terms: D001741:Black or African American / Q000235:genetics*; D015992:Body Mass Index; D056915:DNA Copy Number Variations; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006021:Glycophorins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D049031:Sarcoglycans / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C409972:GYPA protein, human; D006021:Glycophorins; D049031:Sarcoglycans; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein