title: Improving the carboxyamidomethyl ester for subtilisin A-catalysed peptide synthesis.
abstract: A series of novel glycine esters was evaluated for efficiency in subtilisin A-CLEA-catalysed peptide synthesis. The reactivity of the easily accessible carboxyamidomethyl (Cam) ester was further enhanced by elongating it with an amino acid residue, thereby creating more recognition space for subtilisin A.
authors: Institute for Molecules and Materials, Radboud University Nijmegen, The Netherlands.
authors: Roseri J A C
authors: RJ
authors: de Beer
authors: Timo
authors: T
authors: Nuijens
authors: Lotte
authors: L
authors: Wiermans
authors: Peter J L M
authors: PJ
authors: Quaedflieg
authors: Floris P J T
authors: FP
authors: Rutjes
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology*; D002384:Catalysis; D004952:Esters / Q000737:chemistry; D005998:Glycine / Q000031:analogs & derivatives*; D010452:Peptide Biosynthesis; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013381:Subtilisins / Q000378:metabolism*
chemical_list: D004952:Esters; D010455:Peptides; D013381:Subtilisins; D005998:Glycine