title: A smart (19) F and (1) H MRI probe with self-immolative linker as a versatile tool for detection of enzymes.
abstract: Here we report on a dual-modal (19) F and (1) H MRI paramagnetic probe with a self-immolative linker, Gd-DOMF-Gal. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd(3+) complex to modulate the (1) H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by (19) F and (1) H MRI using this molecular design is proposed.
authors: Department for High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany. aneta.keliris@tuebingen.mpg.de
authors: Aneta
authors: A
authors: Keliris
authors: Ilgar
authors: I
authors: Mamedov
authors: Gisela E
authors: GE
authors: Hagberg
authors: Nikos K
authors: NK
authors: Logothetis
authors: Klaus
authors: K
authors: Scheffler
authors: Jörn
authors: J
authors: Engelmann
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D005461:Fluorine; D005682:Gadolinium; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011522:Protons; D001616:beta-Galactosidase / Q000737:chemistry
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D011522:Protons; D005461:Fluorine; D005682:Gadolinium; D001616:beta-Galactosidase