title: Finite mixture regression model analysis on antipsychotics induced weight gain: investigation of the role of the serotonergic genes.
abstract: Antipsychotics-induced weight gain is a complex phenomenon with a relevant underlying genetic basis. Polymorphisms of serotonin receptors and related proteins were genotyped in 139 schizophrenia patients and incorporated as covariates in a mixture regression model of weight gain in combination with clinical covariates. The HTR1D rs6300 polymorphism was showing a slight significance conferring risk for obesity (heavy weight gain group) under additive model. After correcting for multiple testing all the genetic predictors were non-significant, however the clinical predictors were associated with the risk of heavy weight gain. These findings suggest a role of ethnicity and olanzapine in increasing the risk for obesity in the heavy weight gain group and haloperidol protecting against heavy weight gain. The mixture regression model appears to be a useful strategy to highlight different weight gain subgroups that are affected differently by clinical and genetic predictors.
authors: Laurentian University, Sudbury, Ontario, Canada.
authors: Behdin
authors: B
authors: Nowrouzi
authors: Renan P
authors: RP
authors: Souza
authors: Clement
authors: C
authors: Zai
authors: Takahiro
authors: T
authors: Shinkai
authors: Marcellino
authors: M
authors: Monda
authors: Jeffrey
authors: J
authors: Lieberman
authors: Jan
authors: J
authors: Volvaka
authors: Herbert Y
authors: HY
authors: Meltzer
authors: James L
authors: JL
authors: Kennedy
authors: Vincenzo
authors: V
authors: De Luca
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000139:chemically induced* / Q000208:ethnology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011985:Receptors, Serotonin / Q000235:genetics*; D012044:Regression Analysis; D012306:Risk; D012559:Schizophrenia / Q000188:drug therapy*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics; D015430:Weight Gain / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase