title: Complex karyotype predicts for inferior outcomes following reduced-intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia.
abstract: Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty-one CLL patients were analysed following transplant; 18-month overall survival (OS), event-free survival (EFS) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with CK (n = 19) versus 83%, 68% and 29% in patients without (n = 32) (P ≤ 0·0001, P ≤ 0·0001, and P = 0·02). In patients with high-risk interphase cytogenetics, CK remained predictive of worse OS (P = 0·02) and EFS (P = 0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.
authors: Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH, USA. samantha.jaglowski@osumc.edu
authors: Samantha M
authors: SM
authors: Jaglowski
authors: Amy S
authors: AS
authors: Ruppert
authors: Nyla A
authors: NA
authors: Heerema
authors: Anissa
authors: A
authors: Bingman
authors: Joseph M
authors: JM
authors: Flynn
authors: Michael R
authors: MR
authors: Grever
authors: Jeffrey A
authors: JA
authors: Jones
authors: Patrick
authors: P
authors: Elder
authors: Steven M
authors: SM
authors: Devine
authors: John C
authors: JC
authors: Byrd
authors: Leslie A
authors: LA
authors: Andritsos
mesh_terms: D000328:Adult; D000368:Aged; D003582:Cytogenetics; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D059785:Karyotype; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D033581:Stem Cell Transplantation / Q000379:methods*; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome