title: [Inflammatory-destructive biomarkers of atherosclerotic  plaques instability. Study of arterial wall and  blood].
abstract: Concentrations of tumor necrosis factor, interleukin 1- and its receptor antagonist, IL-6, IL-8, IL-18, IL-2, ligand of CD40 receptor (CD40L), high sensitive C-reactive protein (hsCRP), monocyte chemotactic protein -1, endothelial monocyte activating protein II, adhesive molecules (sICAM-1 and sVCAM-1), matrix metalloproteinase (MMP-3, MMP-7, MMP-9), tissue inhibitor of metalloproteinase (TIMP-1) and endothelin-1 were studied in blood and in coronary artery intima/media of men with coronary atherosclerosis without acute coronary syndrome. Blood levels of hsCRP, IL-8, IL-6 and CD40L were higher, while blood levels of sVCAM and TIMP-1 were lower in men with prevalence of unstable atherosclerotic plaques compared to men with prevalence of stable atherosclerotic plaques in coronary arteries. Blood levels of hsCRP, IL-6 and IL-8 correlated with characteristics of coronary artery atherosclerotic plaques instability. Correlation between hsCRP blood level and hsCRP concentration in coronary artery intima/media material was also revealed.
authors: Iu I
authors: IuI
authors: Ragino
authors: A M
authors: AM
authors: Cherniavskiĭ
authors: Ia V
authors: IaV
authors: Polonskaia
authors: A M
authors: AM
authors: Volkov
authors: E V
authors: EV
authors: Kashtanova
authors: S Iu
authors: SIu
authors: Tsymbal
authors: E M
authors: EM
authors: Polovnikova
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003331:Coronary Vessels / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000097:blood / Q000453:epidemiology; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000453:epidemiology; D015995:Prevalence
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators