title: Pyrosequencing of the rabies virus glycoprotein gene to demonstrate absence of vaccine-associated rabies cases following oral vaccination.
abstract: Replication competent vaccines have been used successfully for the control of terrestrial rabies, mainly in wildlife; however, these vaccine strains occasionally may induce rabies. In this study, a pyrosequencing protocol for the rapid identification of vaccine-associated rabies viruses was applied to the 2008-2011 Italian epidemic. There was no evidence of vaccine-associated rabies cases following oral vaccination of foxes with the SAG2 and SADB19 vaccine strains.
authors: National Reference Centre for Rabies and OIE Collaborating Centre for Diseases at the Animal-Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, Legnaro, Padova, Italy. pdebenedictis@izsvenezie.it
authors: Paola
authors: P
authors: De Benedictis
authors: Cristian
authors: C
authors: De Battisti
authors: Sabrina
authors: S
authors: Marciano
authors: Franco
authors: F
authors: Mutinelli
authors: Ilaria
authors: I
authors: Capua
authors: Giovanni
authors: G
authors: Cattoli
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005589:Foxes; D014943:Global Health; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism*; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014611:Vaccination; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D010446:Peptide Fragments; D011819:Rabies Vaccines; D014764:Viral Proteins; C583075:rabies virus glycoprotein peptide