title: Detection of new methicillin-resistant Staphylococcus aureus strains that carry a novel genetic homologue and important virulence determinants.
abstract: In this study, 18 methicillin-resistant Staphylococcus aureus (MRSA) isolates harboring staphylococcal cassette chromosome mec (SCCmec) type XI, recovered in the Dutch-German Euregio, were characterized by DNA microarrays. In contrast to previous data, we found two MRSA strains of different clonal lineages possessing SCCmec XI that carried important virulence determinants. The worrisome emergence of such toxigenic MRSA strains raises concerns that MRSA strains with enhanced virulence potential and impaired detectability by standard molecular assays may spread in Europe.
authors: Department of Medical Microbiology, University of Groningen, Groningen, The Netherlands.
authors: Artur J
authors: AJ
authors: Sabat
authors: Mahir
authors: M
authors: Koksal
authors: Viktoria
authors: V
authors: Akkerboom
authors: Stefan
authors: S
authors: Monecke
authors: André
authors: A
authors: Kriegeskorte
authors: Ron
authors: R
authors: Hendrix
authors: Ralf
authors: R
authors: Ehricht
authors: Robin
authors: R
authors: Köck
authors: Karsten
authors: K
authors: Becker
authors: Alexander W
authors: AW
authors: Friedrich
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016000:Cluster Analysis; D005858:Germany / Q000453:epidemiology; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D046228:Microarray Analysis; D008826:Microbial Sensitivity Tests; D058889:Molecular Typing; D009426:Netherlands / Q000453:epidemiology; D020411:Oligonucleotide Array Sequence Analysis; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors