title: A single spinal lesion arising from an intradural meningioma contiguous with an extradural lymphoma.
abstract: The authors describe here a unique case of contiguous, synchronous meningioma and lymphoma in the spinal column. Both tumors were present at the same vertebral level, one intradural and the other extradural. A patient presented with bilateral leg pain, acute weakness, and sensory loss in the lower extremities. Magnetic resonance imaging revealed an intradural mass at T6-7 with ambiguous boundaries relative to the thecal sac and compressing the spinal cord. The patient underwent resection of the epidural and intradural mass at T6-7. Histopathology revealed the epidural specimen to be a double-hit B-cell lymphoma and the intradural mass to be a transitional meningioma. Postoperatively, the patient did well, with an immediate return of strength and sensation. A postoperative MR image showed complete resection of the intradural mass. The authors suggest that biopsy may be prudent in patients with known systemic lymphoma presenting with a spinal lesion that has unclear boundaries relative to the thecal sac prior to commencing radiation and chemotherapy.
authors: Department of Neurosurgery, University of California, San Diego, California 92093-0987, USA. pjankowski@ucsd.edu
authors: Pawel P
authors: PP
authors: Jankowski
authors: Lissa C
authors: LC
authors: Baird
authors: Sassan
authors: S
authors: Keshavarzi
authors: Mary E
authors: ME
authors: Goolsby
authors: William R
authors: WR
authors: Taylor
authors: Andrew D
authors: AD
authors: Nguyen
mesh_terms: D059186:Chemoradiotherapy, Adjuvant; D003131:Combined Modality Therapy; D015174:Epidural Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005629:Frozen Sections; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007796:Laminectomy; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008578:Meninges / Q000473:pathology; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013117:Spinal Cord Compression / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013904:Thoracic Vertebrae / Q000473:pathology