title: Flabelliferins A and B, sesterterpenoids from the South Pacific sponge Carteriospongia flabellifera.
abstract: Two new sesterterpenoids named flabelliferins A (1) and B (2) were isolated from the lipophilic extract of the sponge Cateriospongia flabellifera, collected in the South Pacific near Vanuatu. The structure and absolute configuration of these two compounds were assigned by a combination of one- and two-dimensional NMR spectroscopy and by Mosher's ester analysis. Flabelliferin A (1) has a rare 25-homocheilanthane carbon skeleton, while flabelliferin B (2) is a 24-nor-25-homoscalarane sesterterpenoid.
authors: Molecular Targets Laboratory, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
authors: Thushara
authors: T
authors: Diyabalanage
authors: Ranjala
authors: R
authors: Ratnayake
authors: Heidi R
authors: HR
authors: Bokesch
authors: Tanya T
authors: TT
authors: Ransom
authors: Curtis J
authors: CJ
authors: Henrich
authors: John A
authors: JA
authors: Beutler
authors: James B
authors: JB
authors: McMahon
authors: Kirk R
authors: KR
authors: Gustafson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009514:Vanuatu
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes; C576026:flabelliferin A; C576027:flabelliferin B