title: [Association between lithium sensitivity and GSK3beta gene polymorphisms in bipolar disorder].
abstract: GSK-3beta codes for an enzyme which is a target for the action of mood stabilizers, lithium and possibly of valproic acid. The relationship between the polymorphisms (SNPs) of GSK-3beta-50T/C and -1727A/T and the effect of lithium was studied among 29 Japanese bipolar patients. It was shown that GSK-3beta-50T/C may be linked with the effect of lithium treatment. There is a significantly higher T-allele frequency in the lithium responders than non-responders (df = 1, chi2 = 6.971, 0.01 > P > 0.001; Yates' continuity correction). However, there is not a significant relationship between the polymorphisms of GSK-3beta-1727A/T and the effect of lithium treatment.
authors: Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara 252-5201, Japan.
authors: Maki
authors: M
authors: Numajiri
authors: Jun
authors: J
authors: Aoki
authors: Kazuhiko
authors: K
authors: Iwahashi
authors: Fumihiko
authors: F
authors: Fukamauchi
authors: Minoru
authors: M
authors: Enomoto
authors: Eiji
authors: E
authors: Yoshihara
authors: Ohshi
authors: O
authors: Murayama
authors: Daisuke
authors: D
authors: Nishizawa
authors: Kazutaka
authors: K
authors: Ikeda
authors: Jun
authors: J
authors: Ishigooka
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D008094:Lithium; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3