title: Softer zwitterionic nanogels for longer circulation and lower splenic accumulation.
abstract: Zwitterionic nanogels of varying stiffness were prepared by tuning their cross-linking densities and reactant contents. In vivo studies of these nanogels show that softer nanogels pass through physiological barriers, especially the splenic filtration, more easily than their stiffer counterparts, consequently leading to longer circulation half-life and lower splenic accumulation. Results from this work emphasize the role of stiffness in designing long-circulating nanoparticles.
authors: Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.
authors: Lei
authors: L
authors: Zhang
authors: Zhiqiang
authors: Z
authors: Cao
authors: Yuting
authors: Y
authors: Li
authors: Jean-Rene
authors: JR
authors: Ella-Menye
authors: Tao
authors: T
authors: Bai
authors: Shaoyi
authors: S
authors: Jiang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001774:Blood Chemical Analysis; D006244:Hardness; D020100:Hydrogels / Q000138:chemical synthesis*; D008422:Materials Testing; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D051381:Rats; D013154:Spleen / Q000737:chemistry*; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels