title: Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging.
abstract: To address the intractable issues such as the low performance or biocompatibility frequently encountered in previous CT, magnetic resonance (MR) and fluorescence trimodal imaging nanoprobes, a nanocomposite has been constructed by decorating gadolinium ions doped upconversion nanoparticle (Gd-doped UCNP) with radiopaque but fluorescence-transparent tantalum oxide (TaO(x), x ≈ 1). The as-synthesized water-soluble nanoparticle showed a litchi-like shape with an average size of ~30 nm and demonstrated extraordinarily high longitudinal and transverse relaxivity values (r(1) = 11.45 mM(-1)s(-1) and r(2) = 147.3 mM(-1)s(-1)) compared with the reported Gd-doped UCNPs to date. Obvious CT contrast enhancement was obtained by the combined effect between the radiopaque TaO(x) shell and the Gd-doped UCNP inner core. Strong upconversion luminescence (UCL) signal could unobstructedly penetrate out in virtue of high transparency of the TaO(x) shell. No mutual interference among different modalities of the upconversion nanolitchi (UCNL) was found, which ensured that the individual merits of every imaging modality could be brought into full play, demonstrated by in vitro and in vivo imagings. Furthermore, UCNLs showed only a slight effect on macrophages and RBCs in vitro and tissue in vivo.
authors: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, PR China.
authors: Qingfeng
authors: Q
authors: Xiao
authors: Wenbo
authors: W
authors: Bu
authors: Qingguo
authors: Q
authors: Ren
authors: Shengjian
authors: S
authors: Zhang
authors: Huaiyong
authors: H
authors: Xing
authors: Feng
authors: F
authors: Chen
authors: Ming
authors: M
authors: Li
authors: Xiangpeng
authors: X
authors: Zheng
authors: Yanqing
authors: Y
authors: Hua
authors: Liangping
authors: L
authors: Zhou
authors: Weijun
authors: W
authors: Peng
authors: Haiyun
authors: H
authors: Qu
authors: Zheng
authors: Z
authors: Wang
authors: Kuaile
authors: K
authors: Zhao
authors: Jianlin
authors: J
authors: Shi
mesh_terms: D000818:Animals; D016923:Cell Death; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry*; D005453:Fluorescence; D006461:Hemolysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D012996:Solutions; D013635:Tantalum / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D010087:Oxides; D012996:Solutions; D013635:Tantalum; C078151:tantalum oxide