title: Fatal human metapneumovirus and influenza B virus coinfection in an allogeneic hematopoietic stem cell transplant recipient.
abstract: Human metapneumovirus (hMPV) infection can occur in all age groups with significant morbidity and mortality. Coinfection with influenza virus occurs mainly with influenza type A and all reported cases recovered completely. We report the case of a 61-year-old man who had hematopoietic stem cell transplant for myelodysplastic syndrome. He was admitted to hospital for septic shock and neutropenia, and blood culture was positive for Pseudomonas aeruginosa. He rapidly developed respiratory failure and required ventilator support. His respiratory culture grew P. aeruginosa and hMPV. His course was complicated by persistent shock requiring vasopressor support, and repeat nasopharyngeal swab was positive for influenza type B and hMPV. His condition rapidly deteriorated, his family elected comfort care, and the patient died shortly thereafter. Coinfection with hMPV and influenza virus type B may have a poor outcome and can be fatal, especially in immunocompromised patients.
authors: Department of Internal Medicine, Saint Elizabeth Health Center, Youngstown, Ohio, USA.
authors: C
authors: C
authors: Ghattas
authors: S B
authors: SB
authors: Mossad
mesh_terms: D060085:Coinfection; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D009981:Influenza B virus / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications* / Q000821:virology; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification*; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000150:complications* / Q000382:microbiology; D014184:Transplantation, Homologous