title: Regioselective synthesis of 2-(2-hydroxyaryl)pyridines from the reactions of benzynes with pyridine N-oxides.
abstract: By modifying the conditions from those in Larock's reported synthesis of 3-(2-hydroxyaryl)pyridines from benzynes, and pyridine N-oxides, we altered the regioselectivity of the reaction toward an efficient synthesis of 2-substituted pyridines. The presence of ethyl propiolate altered the regioselectivity to afford 3-substituted pyridine products instead. We conducted appropriate control experiments that enable a full understanding of the mechanism.
authors: Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
authors: Balagopal S
authors: BS
authors: Shaibu
authors: Rahul Kisan
authors: RK
authors: Kawade
authors: Rai-Shung
authors: RS
authors: Liu