title: Activity of the inflammatory process in different types of unstable atherosclerotic plaques.
abstract: Inflammatory biomarkers and chemoattractants characteristic and important for different types (lipid; inflammatory erosive; degenerative necrotic) of unstable plaques in coronary arteries were identified and studied in male patients with coronary atherosclerosis without acute coronary syndrome we studied. Among the three types of unstable plaques, elevated concentrations of IL-1β, IL-6, IL-8, IL-18 and monocyte chemotactic protein-1 were characteristic of not only inflammatory erosive type, but also lipid type compared with degenerative necrotic type. Thus, intensification of the inflammatory process plays an important role in the development of not only inflammatory and destructive, but also of lipid type of unstable atherosclerotic plaques.
authors: Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. ragino@mail.ru
authors: Yu I
authors: YI
authors: Ragino
authors: A M
authors: AM
authors: Chernyavski
authors: Ya V
authors: YV
authors: Polonskaya
authors: A M
authors: AM
authors: Volkov
authors: E V
authors: EV
authors: Kashtanova
mesh_terms: D018932:Chemokine CCL2 / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000276:immunology* / Q000378:metabolism; D003331:Coronary Vessels / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism*; D008055:Lipids / Q000032:analysis; D008297:Male; D058226:Plaque, Atherosclerotic / Q000276:immunology* / Q000378:metabolism
chemical_list: D018932:Chemokine CCL2; D020382:Interleukin-18; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D007378:Interleukins; D008055:Lipids