title: The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer.
abstract: OBJECTIVE
  The purpose of this study is to investigate the diagnostic accuracy of 3.0Tesla (3T) diffusion-weighted magnetic resonance imaging (MRI) in addition to conventional MRI for the detection of lymphadenopathy in patients with early stage cervical cancer compared to histopathological evaluation of the systematically removed pelvic lymph nodes as reference standard.
  
  
  METHODS
  68 fédération internationale de gynécologie obstétrique (FIGO) stage Ia2 to IIb cervical cancer patients were included. Sensitivity and specificity rates for two experienced observers were computed for the detection of lymphatic metastasis. Reproducibility of conventional MRI was tested by kappa statistics. The variables included in the analysis were: size of the long axis, short axis, ratio short to long axis and apparent diffusion coefficient (ADC).
  
  
  RESULTS
  Nine patients had 15 positive pelvic nodes at histopathological examination. The sensitivity and specificity of lymphatic metastasis detection by predefined conventional MRI characteristics was 33% (95% Confidence Interval (CI) 3-64) and 83% (95% CI 74-93) on patient level, and 33% (95% CI 7-60) and 97% (95% CI 95-99) on regional level respectively for observer 1. For observer 2 the sensitivity was 33% (95% CI 3-64) and the specificity 93% (95% CI 87-100) on patient level, and 25% (95% CI 1-50) and 98% (95% CI 97-100) on regional level, respectively. The kappa-value for reproducibility of metastasis detection on regional level was 0.50. The short axis diameter showed the highest diagnostic accuracy (area under the curve (AUC)=0.81 95% CI 0.70-0.91); ADC did not improve diagnostic accuracy (AUC=0.83 95% CI 0.73-0.93).
  
  
  CONCLUSIONS
  Diffusion-weighted MRI did not result in additional diagnostic value compared to conventional MRI.
authors: Department of Gynecology and Obstetrics, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands. w.klerkx@umcutrecht.nl
authors: W M
authors: WM
authors: Klerkx
authors: W B
authors: WB
authors: Veldhuis
authors: A M
authors: AM
authors: Spijkerboer
authors: M A
authors: MA
authors: van den Bosch
authors: W P
authors: WP
authors: Mali
authors: A P
authors: AP
authors: Heintz
authors: S
authors: S
authors: Bipat
authors: D M
authors: DM
authors: Sie-Go
authors: J
authors: J
authors: van der Velden
authors: H W
authors: HW
authors: Schreuder
authors: J
authors: J
authors: Stoker
authors: P H
authors: PH
authors: Peeters
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D018262:Adenocarcinoma, Clear Cell / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000556:secondary / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery; D016001:Confidence Intervals; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D015588:Observer Variation; D010388:Pelvis; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D055815:Young Adult