title: Membrane affinity and antibacterial properties of cationic polyelectrolytes with different hydrophobicity.
abstract: The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane-destroying efficacy of the antimicrobial polymers.
authors: Laboratory of Interfaces and Nanostructures, Institute of Chemistry, Eötvös Loránd University, Budapest, Hungary. kisseva@chem.elte.hu
authors: Eva
authors: E
authors: Kiss
authors: Elisabeth T
authors: ET
authors: Heine
authors: Katalin
authors: K
authors: Hill
authors: Ying Chun
authors: YC
authors: He
authors: Nina
authors: N
authors: Keusgen
authors: Csanád B
authors: CB
authors: Pénzes
authors: Donát
authors: D
authors: Schnöller
authors: Gergő
authors: G
authors: Gyulai
authors: Aleksandra
authors: A
authors: Mendrek
authors: Helmut
authors: H
authors: Keul
authors: Martin
authors: M
authors: Moeller
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002412:Cations; D004573:Electrolytes / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D008563:Membrane Lipids / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D013050:Spectrometry, Fluorescence; D013211:Staphylococcus aureus / Q000187:drug effects; D013500:Surface Tension; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D002412:Cations; D004573:Electrolytes; D008563:Membrane Lipids