title: [Estimation of the hypoglycemic effect of phytoecdysteroids].
abstract: A series of phytoecodysteroids, including alpha-ecdysone, 2-deoxy-alpha-ecdysone, and 2-deoxyecdysterone isolated from Silene praemixta, integristerone A and ecdysterone isolated from Rhaponticum carthamoides and 22-acetylcyasterone and turkesterone isolated from Ajuga turkestanica, exhibit a pronounced hypoglycemic effect in experiments on intact male rats. The most active compounds--ecdysteron and turkesterone--also produce an expressed hypoglycemic effect in animals with model hyperglycemia induced by the administration of glucose, adrenalin and alloxan. Phytoecdysteroids are substances possessing protein-anabolic activity and are somewhat similar to steranobols in this aspect. Phytoecdysteroids exhibit unidirectional effect and are well comparable with steranabol actionon the carbohydrate metabolism.
authors: V N
authors: VN
authors: Syrov
authors: N Kh
authors: NKh
authors: Iuldasheva
authors: F R
authors: FR
authors: Égamova
authors: G I
authors: GI
authors: Ismailova
authors: N D
authors: ND
authors: Abdullaev
authors: Z A
authors: ZA
authors: Khushbaktova
mesh_terms: D031328:Ajuga / Q000737:chemistry; D000818:Animals; D019659:Asteraceae / Q000737:chemistry; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D029748:Caryophyllaceae / Q000737:chemistry; D026461:Ecdysteroids / Q000737:chemistry / Q000494:pharmacology*; D004441:Ecdysterone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008696:Methandrostenolone / Q000737:chemistry / Q000494:pharmacology; D010840:Phytosterols / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D001786:Blood Glucose; D026461:Ecdysteroids; D007004:Hypoglycemic Agents; D010840:Phytosterols; D004441:Ecdysterone; C017787:turkesterone; D008696:Methandrostenolone