title: [Galectin 3--a new biomarker for diagnostics and outcome of chronic heart failure].
abstract: Galectins--lectins binding β-galactosides their properties and biological role have been described. Galectines family in mammalians consists of 15 members. Galectin-3 is atypical specimen of galectins family. Its participation in fibrosis, cardiac remodeling, immune and inflammation responses have been shown. Employment galectin-3 as new independent biomarker for diagnosis of acute heart failure and outcome predictor in patients with chronic heart failure (HF) are discussed. Diagnostic and prognostic values of galectin-3 are compared with famous and wide using HF marker NT-proBNP. Combined employing biomarkers for diagnostic and prognostic purpose of HF have been discussed. Using galectin-3 as therapeutic target in treatment of chronic HF in future is suggested.
authors: S V
authors: SV
authors: Lakomkin
authors: A A
authors: AA
authors: Skvortsov
authors: T V
authors: TV
authors: Goriunova
authors: V P
authors: VP
authors: Masenko
authors: S N
authors: SN
authors: Tereshchenko
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005355:Fibrosis / Q000378:metabolism; D005544:Forecasting; D037502:Galectin 3 / Q000378:metabolism*; D006333:Heart Failure / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007109:Immunity / Q000502:physiology; D007249:Inflammation / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000639:trends; D011237:Predictive Value of Tests; D011379:Prognosis; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D015415:Biomarkers; D037502:Galectin 3