title: A feasibility analysis of implementing interventions for discordant couples in 14 African countries:  implications for epidemic control.
abstract: We find interventions targeting serodiscordant couples (SDC) may not be feasible in countries where HIV prevalence is less than 5%, because only 3-19/1000 individuals are HIV-positive/negative and in SDC. Interventions may be feasible in countries where prevalence is greater than 10%, because 34-48/1000 individuals are HIV-positive/negative and in SDC. We calculated that 20-27% of all HIV-positive individuals, but less than 6% of all HIV-negative individuals, are in SDC. Consequently, targeting HIV-positive partners could significantly reduce transmission, whereas targeting HIV-negative partners may have little impact.
authors: Center for Biomedical Modeling, Semel Institute of Neuroscience & Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.
authors: Brian J
authors: BJ
authors: Coburn
authors: Sally
authors: S
authors: Blower
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D058872:Epidemics / Q000517:prevention & control; D005191:Family Characteristics; D005240:Feasibility Studies; D005260:Female; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D008297:Male; D015995:Prevalence; D012747:Sexual Partners; D055815:Young Adult