title: Pathogenesis and pathophysiology of endometriosis.
abstract: Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition.
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Madigan Healthcare System, Tacoma, Washington, USA.
authors: Richard O
authors: RO
authors: Burney
authors: Linda C
authors: LC
authors: Giudice
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002470:Cell Survival; D004715:Endometriosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications; D018919:Neovascularization, Physiologic