title: [Ingavirin treatment of experimental parainfluenza pneumonia in Syrian hamsters].
abstract: Parainfluenza viruses affect the upper respiratory tract in all age group patients, in children aged 6 months to 3 years in particular. The most urgent task is to design drugs to treat parainfluenza. This investigation studied the antiviral activity of Ingavirin (2-(imidazole-4-yl) ethanamide of pentandioic-1,5 acid) on a model of parainfluenza infection in Syrian hamsters. The drug was shown to restrict the infectious process in animal lung tissue. This restriction manifested itself as reductions in the infectious titer of parainfluenza virus in the lung tissue, in the degree of pulmonary edema and tissue cell infiltration, and in virus-specific lesion of bronchial epithelial cells. The in vitro experiments demonstrated the ability of Ingavirin to diminish the infective activity of viral descendants. The finding allows one to consider Ingavirin to be a promising antiviral agent that is active against parainfluenza infection in vivo.
authors: V V
authors: VV
authors: Zarubaev
authors: A V
authors: AV
authors: Garshinina
authors: N A
authors: NA
authors: Kalinina
authors: S V
authors: SV
authors: Beliaevskaia
authors: V E
authors: VE
authors: Nebol'sin
authors: O I
authors: OI
authors: Kiselev
authors: D V
authors: DV
authors: Reĭkhart
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D000818:Animals; D000831:Animals, Newborn; D002208:Caproates; D002675:Child, Preschool; D006224:Cricetinae; D003998:Dicarboxylic Acids / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007223:Infant; D008168:Lung / Q000473:pathology / Q000821:virology; D008647:Mesocricetus; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects / Q000302:isolation & purification; D018184:Paramyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D011024:Pneumonia, Viral / Q000188:drug therapy* / Q000473:pathology; D012254:Ribavirin / Q000494:pharmacology; D019562:Viral Load
chemical_list: D000577:Amides; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide; D012254:Ribavirin