title: Organic cation transporters in the blood-air barrier: expression and implications for pulmonary drug delivery.
abstract: Studies concerning the impact that hepatic, renal and intestinal transporters have on drug disposition have been frequently reported in the literature. Surprisingly, however, little is known regarding the distribution and function of drug-transporter proteins of the lung epithelium. Many drugs (delivered to the lung) have a net positive charge and, thus, are potential substrates of organic cation transporters; currently marketed compounds (e.g., bronchodilators), as well as novel drug candidates in development, are such substrates. It is the aim of this review to summarize the current state of organic cation-transporter expression analysis in the lung and in in vitro models of bronchial and alveolar barriers. Moreover, activity of selected transporters in lung epithelium in situ and in vitro will be highlighted, and their potential role in pulmonary drug disposition will be addressed. One example included here is the transporter-dependent absorption of beta2-agonists in respiratory epithelial cells.
authors: School of Pharmacy & Pharmaceutical Sciences, Trinity College Dublin, Panoz Institute, Dublin, Ireland.
authors: Johanna Jessica
authors: JJ
authors: Salomon
authors: Carsten
authors: C
authors: Ehrhardt
mesh_terms: D000042:Absorption; D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D015824:Blood-Air Barrier / Q000187:drug effects / Q000378:metabolism*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000378:metabolism; D002199:Capillary Permeability; D002626:Chemistry, Pharmaceutical; D006801:Humans; D027701:Organic Cation Transport Proteins / Q000187:drug effects / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D020545:Respiratory Mucosa / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D027701:Organic Cation Transport Proteins; D004364:Pharmaceutical Preparations