title: Primary vulvar Ewing sarcoma/primitive neuroectodermal tumor: a report of one case and review of the literature.
abstract: BACKGROUND
  Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) are aggressive malignancies characterized by translocation involving the EWS gene. Primary extraskeletal ES/PNET rarely affects the female genital tract.
  
  
  METHODS
  We report the case of a 20-year-old female, who presented with a rapidly growing painful mass arising from the left labium majus for six months. Multiple lesions in bones and nodules in lungs were considered metastasis. The diagnosis was established by immunohistochemical stain and reverse transcriptase polymerase chain reaction analysis. The patient ceased treatment and died of respiratory failure one month after discharge.
  
  
  CONCLUSIONS
  Vulvar ES/PNET mainly affects adolescent females. ES/PNET should be considered in the differential diagnosis of tumors involving the lower gynecologic tract in adolescent female.
authors: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
authors: Jie
authors: J
authors: Yang
authors: Qi
authors: Q
authors: Guo
authors: Yunpeng
authors: Y
authors: Yang
authors: Junji
authors: J
authors: Zhang
authors: Jinghe
authors: J
authors: Lang
authors: Honghui
authors: H
authors: Shi
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000556:secondary*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000556:secondary*; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology*; D055815:Young Adult