title: Adiponectin plasma levels decrease after surgery in pediatric patients with congenital heart disease.
abstract: OBJECTIVE
  Adiponectin is a protein secreted by adipose tissue and involved in inflammatory process as well as in metabolic regulation. The aim of this study was to examine the response of plasma adiponectin to cardiac surgery in children with congenital defects to determine whether its measurement is associated to the response to injury.
  
  
  METHODS
  Twenty-five pediatric patients undergoing heart surgery for correction of congenital defects were studied. Adiponectin plasma levels, obtained pre- and three times postoperatively, were determined by dedicated ELISA. Brain natriuretic peptide (BNP) plasma levels were also determined.
  
  
  RESULTS
  Adiponectin levels are highest in the first month of life (p=0.004 newborns vs. children) with a progressive fall in the next few years. After surgery, adiponectin increased slowly over a 1-month period, following an initial decrease in the first 3 days.
  
  
  CONCLUSIONS
  Adiponectin could be involved in the acute response to injury although further investigation into the relationship between adiponectin, glucose regulation and inflammatory process is necessary to examine the issue of the adiponectin decrease after surgery from a more integrated prospective.
authors: Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy.
authors: Chiara
authors: C
authors: Caselli
authors: Massimiliano
authors: M
authors: Cantinotti
authors: Silvia
authors: S
authors: Del Ry
authors: Manuela
authors: M
authors: Cabiati
authors: Tommaso
authors: T
authors: Prescimone
authors: Simona
authors: S
authors: Storti
authors: Bruno
authors: B
authors: Murzi
authors: Aldo
authors: A
authors: Clerico
authors: Daniela
authors: D
authors: Giannessi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood
chemical_list: D052242:Adiponectin; D020097:Natriuretic Peptide, Brain