title: Enantioselective allylic thioetherification: the effect of phosphoric acid diester on iridium-catalyzed enantioconvergent transformations.
abstract: You'll take the high road and I'll take the low road: Enantioenriched allylic thioethers have been synthesized from chiral racemic allylic alcohols. The combination of an Ir-(P,alkene) complex and dibutyl phosphoric acid are required to attain high selectivities. Mechanistic studies uncover an enantioconvergent transformation in which substrate enantiomers react along different pathways to give the same product (see scheme; cod=1,5-cyclooctadiene).
authors: ETH Zürich, HCI H335, 8093 Zürich, Switzerland.
authors: Markus
authors: M
authors: Roggen
authors: Erick M
authors: EM
authors: Carreira
mesh_terms: D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D010755:Organophosphates; D020005:Propanols; D013440:Sulfides; C006463:allyl alcohol; D007495:Iridium