title: [Effect of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular functions].
abstract: OBJECTIVE
  To compare the effects of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular function.
  
  
  METHODS
  A single-masked, randomized, parallel, 4-week-long study. One hundred elderly volunteers without respiratory or cardiovascular diseases underwent a pulmonary function test, blood pressure and pulse measurements, and 12-lead electrocardiography. The patients were divided into 2 groups, the Brimonidine group and the Timolol group.
  
  
  RESULTS
  The one-second forced expiratory volume (FEV1.0), generally used for respiratory function, showed a significantly greater reduction in the Timolol group. The decrease in systolic blood pressure in the Timolol group was significantly smaller than in the Brimonidine group. The decrease in pulse rate in the Brimonidine group was significantly smaller than in the Timolol group. There were no appreciable findings or abnormal changes in the 12-lead electrocardiograms in either group.
  
  
  CONCLUSIONS
  Brimonidine is an antiglaucoma agent with lower pulmonary risk than timolol.
authors: Kanto Central Hospital, the Mutual Aid Association of Public School Teachers, Tokyo, Japan. araie-tky@umin.net
authors: Makoto
authors: M
authors: Araie
authors: Mitsuru
authors: M
authors: Adachi
mesh_terms: D060433:Administration, Ophthalmic; D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D000068438:Brimonidine Tartrate; D002319:Cardiovascular System / Q000187:drug effects*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008297:Male; D011674:Pulse; D011810:Quinoxalines / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage*
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000319:Adrenergic beta-Antagonists; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D013999:Timolol