title: Carbohydrate mimics and lectins: a source of new drugs and therapeutic opportunities.
abstract: Mimics of oligosaccharides capable of interfering with lectin activity are currently being pursued by a number of groups in an effort to produce tools for glycobiology and to design antagonists of medically relevant lectins. The field is reviewed in this chapter. After a brief overview of the state of the art, examples from our and others' studies on the dendritic cell receptor DC-SIGN are illustrated.
authors: Universita' degli Studi di Milano, Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133, Milano, Italy. jose.reina@unimi.it
authors: Jose J
authors: JJ
authors: Reina
authors: Anna
authors: A
authors: Bernardi
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology*; D032701:Biomimetics / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology*; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D037102:Lectins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D037181:Lectins, C-Type / Q000037:antagonists & inhibitors / Q000378:metabolism; D008958:Models, Molecular; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000378:metabolism; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D002241:Carbohydrates; D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin