title: Serum microRNA biomarkers for drug-induced liver injury.
abstract: New biomarkers of drug-induced liver injury (DILI) are required in the clinic and in preclinical pharmaceutical evaluation. Liver-enriched microRNAs are promising serum biomarkers of acetaminophen-induced acute liver injury in mice. The utility of circulating microRNAs as biomarkers of human acute DILI is discussed in the context of correlation with existing biomarkers of liver injury and patient outcomes in acetaminophen toxicity, mechanisms of cellular microRNA release, and their potential advantages over current clinical biomarkers of DILI.
authors: MRC Center for Drug Safety Science, Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
authors: P J
authors: PJ
authors: Starkey Lewis
authors: M
authors: M
authors: Merz
authors: P
authors: P
authors: Couttet
authors: O
authors: O
authors: Grenet
authors: J
authors: J
authors: Dear
authors: D J
authors: DJ
authors: Antoine
authors: C
authors: C
authors: Goldring
authors: B K
authors: BK
authors: Park
authors: J G
authors: JG
authors: Moggs
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008099:Liver / Q000187:drug effects; D051379:Mice; D035683:MicroRNAs / Q000097:blood*
chemical_list: D015415:Biomarkers; C531907:MIRN122 microRNA, human; D035683:MicroRNAs