title: Immunoprofile of mucinous non-neoplastic cyst of the pancreas.
abstract: BACKGROUND
  A recently described mucinous non-neoplastic cyst (MNNC) of the pancreas is a benign cyst and should be distinguished from mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm (IPMN) due to different management and prognosis. The immunoprofile of MNNC has not been well studied.
  
  
  METHODS
  Twenty-three MNNCs diagnosed on surgical resection were retrieved. Immunohistochemical (IHC) staining was performed on surgically resected specimen. Sixteen IPMN and 15 MCN cases were also retrieved for comparison. Cyst fluid carcinoembryonic antigen and amylase concentrations were retrieved.
  
  
  RESULTS
  MNNCs were randomly located in the pancreas and were either unilocular or multilocular cysts that were lined by a single layer of bland columnar or cuboidal mucinous cells and supported by paucicellular stroma. The glandular epithelial cells were diffusely positive for CK7 (100%) and PDX-1 (65%); focally positive for CD10 (superficial, 65%), CD99 (basally, 100%), CDX-2 (17%), and CK20 (4%); and negative for MUC2. Only rare stromal cells in the cyst wall were weakly positive for estrogen receptor or progesterone receptor in only 6% of cases and negative for inhibin. These results were also compared with the immunoprofile of IPMN and MCN.
  
  
  CONCLUSIONS
  Although MNNC shares some IHC markers with IPMN or MCN, an IHC panel can help distinguish MNNC from IPMN or MCN. The results suggest that MNNC is different from IPMN and MCN.
authors: Department of Pathology, Northwestern Memorial Hospital, Northwestern University, Chicago, IL 60611, USA.
authors: Bing
authors: B
authors: Zhu
authors: Xiaoqi
authors: X
authors: Lin
mesh_terms: D000071443:12E7 Antigen; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D000368:Aged; D000681:Amylases / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D002272:Carcinoembryonic Antigen / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000235:genetics; D020420:Cyst Fluid / Q000737:chemistry; D018291:Cystadenoma, Mucinous / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000235:genetics; D010181:Pancreatic Cyst / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D015534:Trans-Activators / Q000235:genetics
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D018398:Homeodomain Proteins; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein; D000681:Amylases; D015260:Neprilysin