title: A retrospective analysis of the effects of meloxicam on the longevity of aged cats with and without overt chronic kidney disease.
abstract: The study sought to examine the effect of long-term meloxicam treatment on the survival of cats with and without naturally-occurring chronic kidney disease at the initiation of therapy. The databases of two feline-only clinics were searched for cats older than 7 years that had been treated continuously with meloxicam for a period of longer than 6 months. Only cats with complete medical records available for review were recruited into the study.The median longevity in the renal group was 18.6 years [95% confidence interval (CI) 17.5-19.2] and the non-renal group was 22 years [95% CI 18.5-23.8]. The median longevity after diagnosis of CKD was 1608 days [95% confidence interval 1344-1919] which compares favourably to previously published survival times of cats with CKD. In both groups the most common cause of death was neoplasia. Long-term treatment with oral meloxicam did not appear to reduce the lifespan of cats with pre-existent stable CKD, even for cats in IRIS stages II and III. Therefore, to address the need for both quality of life and longevity in cats with chronic painful conditions, meloxicam should be considered as a part of the therapeutic regimen.
authors: 1The Cat Clinic, 1 Miller Street, Prahran, Melbourne, Australia. info@catdoctor.com.au
authors: Richard A
authors: RA
authors: Gowan
authors: Randolph M
authors: RM
authors: Baral
authors: Amy E
authors: AE
authors: Lingard
authors: Melissa J
authors: MJ
authors: Catt
authors: Wibke
authors: W
authors: Stansen
authors: Laura
authors: L
authors: Johnston
authors: Richard
authors: R
authors: Malik
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D001315:Australia / Q000453:epidemiology; D002371:Cat Diseases / Q000188:drug therapy* / Q000453:epidemiology*; D002415:Cats; D007677:Kidney Function Tests; D008136:Longevity; D000077239:Meloxicam; D010003:Osteoarthritis / Q000188:drug therapy / Q000662:veterinary*; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary; D012189:Retrospective Studies; D012307:Risk Factors; D013843:Thiazines / Q000008:administration & dosage* / Q000009:adverse effects; D013844:Thiazoles / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam