title: A possible predictive marker of progression for hepatocellular carcinoma.
abstract: The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC.
authors: Institute of Food Sciences, CNR, Avellino.
authors: Michele
authors: M
authors: DI Stasio
authors: Maria Grazia
authors: MG
authors: Volpe
authors: Giovanni
authors: G
authors: Colonna
authors: Melissa
authors: M
authors: Nazzaro
authors: Miriam
authors: M
authors: Polimeno
authors: Stefania
authors: S
authors: Scala
authors: Giuseppe
authors: G
authors: Castello
authors: Susan
authors: S
authors: Costantini