title: The role of massive transfusion protocols in obstetrics.
abstract: Obstetric hemorrhage is a leading cause of maternal mortality worldwide. New concepts involving the pathophysiology of hemorrhage have been described and include early activation of both the protein C and fibrinolytic pathways. New tendencies in hemorrhage treatment include the use of hemostatic resuscitation. Massive transfusion protocols involve the early utilization of blood products and limit the traditional approach of early massive crystalloid based resuscitation. The evidence behind hemostatic resuscitation is still limited.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555-0587, USA. ldpachec@utmb.edu
authors: Luis D
authors: LD
authors: Pacheco
authors: George R
authors: GR
authors: Saade
authors: Maged M
authors: MM
authors: Costantine
authors: Steven L
authors: SL
authors: Clark
authors: Gary D V
authors: GD
authors: Hankins
mesh_terms: D001792:Blood Platelets; D001803:Blood Transfusion / Q000379:methods*; D004912:Erythrocytes; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use; D006470:Hemorrhage / Q000628:therapy*; D006801:Humans; D007744:Obstetric Labor Complications / Q000628:therapy*; D010949:Plasma; D011247:Pregnancy; D065227:Transfusion Reaction
chemical_list: C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen