title: Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
abstract: We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
authors: Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors: Cynthia
authors: C
authors: Sandor
authors: Wanbo
authors: W
authors: Li
authors: Wouter
authors: W
authors: Coppieters
authors: Tom
authors: T
authors: Druet
authors: Carole
authors: C
authors: Charlier
authors: Michel
authors: M
authors: Georges
mesh_terms: D000818:Animals; D002417:Cattle; D018797:Cell Cycle Proteins / Q000235:genetics; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D008040:Genetic Linkage; D016678:Genome; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D059765:Homologous Recombination / Q000235:genetics*; D006801:Humans; D008025:Ligases; D008297:Male; D015877:Miosis / Q000235:genetics; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013076:Sperm Count; D013094:Spermatozoa / Q000166:cytology*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; C507675:REC8 protein, human; D011495:Histone-Lysine N-Methyltransferase; C544431:PRDM9 protein, human; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; C527435:RNF212 protein, human