title: Chemometric and statistical evaluation of calibration curves in pharmaceutical analysis -- a short review on trends and Recommendations.
abstract: The calibration of an analytical method is a very important part of its development, and only the proper statistical and chemometric evaluation of the results, together with understanding this process, allows good results. The purpose of this minireview is to call the reader's attention to the major problems in calibration: curvilinearity, heteroscedasticity, presence of outliers, transformation of results, and distribution and autocorrelation of residuals. The common misunderstandings and mistakes are emphasized to inform the reader. Additionally, the computational package "quantchem" for GNU R environment, allowing full and automatic calibration evaluation, is presented.
authors: Medical University of Lublin, Department of Medicinal Chemistry, Lublin, Poland. lukasz.komsta@umlub.pl
authors: Łukasz
authors: Ł
authors: Komsta
mesh_terms: D002138:Calibration; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003627:Data Interpretation, Statistical; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations