title: Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates.
abstract: We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-π-benzyl complex generated from (coumarinyl)methyl acetates.
authors: Haldia Institute of Technology, West Bengal, India. chatterjee_k80@yahoo.co.in
authors: Kalicharan
authors: K
authors: Cattopadhyay
authors: Antonio
authors: A
authors: Recio
authors: Jon A
authors: JA
authors: Tunge
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008745:Methylation; D010165:Palladium / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D003374:Coumarins; D007659:Ketones; D011759:Pyrrolidines; D010165:Palladium; C032519:pyrrolidine