title: [The role of serotonin in the immune system development and functioning during ontogenesis].
abstract: In this study, we investigated the influence of serotonin on the development and functioning of T- and B-cell-mediated immunity during ontogenesis using the pharmacological model of serotonin depletion in rat fetuses. It has been demonstrated that prenatal serotonin deficiency resulted in a decrease in thymus and spleen weights, changes in their cellular composition, and long-lasting disturbances in cell-mediated and humoral immunity in postnatal ontogenesis. The data obtained suggest that serotonin may be considered a morphogenic factor in development of the immune system.
authors: V I
authors: VI
authors: Mel'nikova
authors: M S
authors: MS
authors: Izvol'skaia
authors: S N
authors: SN
authors: Voronova
authors: L A
authors: LA
authors: Zakharova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D007107:Immune System / Q000187:drug effects / Q000196:embryology* / Q000254:growth & development*; D007111:Immunity, Cellular / Q000502:physiology; D056724:Immunity, Humoral / Q000502:physiology; D008297:Male; D009929:Organ Size; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000254:growth & development; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000254:growth & development
chemical_list: D012702:Serotonin Antagonists; D012701:Serotonin; D010134:Fenclonine