title: Acyl coenzyme A synthetase long-chain 1 (ACSL1) gene polymorphism (rs6552828) and elite endurance athletic status: a replication study.
abstract: The aim of this study was to determine the association between the rs6552828 polymorphism in acyl coenzyme A synthetase (ACSL1) and elite endurance athletic status. We studied 82 Caucasian (Spanish) World/Olympic-class endurance male athletes, and a group of sex and ethnically matched healthy young adults (controls, n=197). The analyses were replicated in a cohort of a different ethnic origin (Chinese of the Han ethnic group), composed of elite endurance athletes (runners) [cases, n=241 (128 male)] and healthy sedentary adults [controls, n=504 (267 male)]. In the Spanish cohort, genotype (P=0.591) and minor allele (A) frequencies were similar in cases and controls (P=0.978). In the Chinese cohort, genotype (P=0.973) and minor allele (G) frequencies were comparable in female endurance athletes and sedentary controls (P=0.881), whereas in males the frequency of the G allele was higher in endurance athletes (0.40) compared with their controls (0.32, P=0.040). The odds ratio (95%CI) for an elite endurance Chinese athlete to carry the G allele compared with ethnically matched controls was 1.381 (1.015-1.880) (P-value=0.04). Our findings suggest that the ACSL1 gene polymorphism rs6552828 is not associated with elite endurance athletic status in Caucasians, yet a marginal association seems to exist for the Chinese (Han) male population.
authors: Department of Biomedicine, European University of Madrid, Madrid, Spain.
authors: Thomas
authors: T
authors: Yvert
authors: Zi-Hong
authors: ZH
authors: He
authors: Catalina
authors: C
authors: Santiago
authors: Yang
authors: Y
authors: Hu
authors: Yan-Chun
authors: YC
authors: Li
authors: Félix
authors: F
authors: Gómez-Gallego
authors: Carmen
authors: C
authors: Fiuza-Luces
authors: Zoraida
authors: Z
authors: Verde
authors: Carlos A
authors: CA
authors: Muniesa
authors: Jesús
authors: J
authors: Oliván
authors: Alfredo
authors: A
authors: Santalla
authors: Jonatan R
authors: JR
authors: Ruiz
authors: Alejandro
authors: A
authors: Lucia
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D054874:Athletic Performance / Q000502:physiology; D003066:Coenzyme A Ligases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People; D055815:Young Adult
chemical_list: D003066:Coenzyme A Ligases