title: Triple-orifice valve repair in severe Barlow disease with multiple-jet mitral regurgitation: report of mid-term experience.
abstract: OBJECTIVE
  Barlow disease represents a surgical challenge for mitral valve repair (MR) in the presence of mitral insufficiency (MI) with multiple regurgitant jets. We hereby present our mid-term experience using a modified edge-to-edge technique to address this peculiar MI.
  
  
  METHODS
  From March 2003 till December 2010, 25 consecutive patients (mean age 54 ± 7 years, 14 males) affected by severe Barlow disease with multiple regurgitant jets were submitted to MR. Preoperative transesophageal echo (TEE) in all the cases showed at least 2 regurgitant jets, involving one or both leaflets in more than one segment. In all the patients, a triple orifice valve (TOV) repair with annuloplasty was performed. Intra-operative TEE and postoperative transthoracic echocardiography (TTE) were carried out to evaluate results of the TOV repair.
  
  
  RESULTS
  There was no in-hospital death and one late death (non-cardiac related). At intra-operative TEE, the three orifices showed a mean total valve area of 2.9 ± 0.1cm(2) (range 2.5-3.3 cm(2)) with no residual regurgitation (2 cases of trivial MI) and no sign of valve stenosis (mean transvalvular gradient 4.6 ± 1.5 mmHg). At follow up (mean 38 ± 22 months), TTE showed favourable MR and no recurrence of significant MI (6 cases of trivial and 1 of mild MI). Stress TTE was performed in 5 cases showing persistent effective valve function (2 cases of trivial MI at peak exercise). All the patients showed significant NYHA functional class improvement.
  
  
  CONCLUSIONS
  This report indicates that the TOV technique is effective in correcting complex Barlow mitral valves with multiple jets. Further studies are required to confirm long-term applicability and durability in more numerous clinical cases.
authors: Cardiac Surgery Unit, Cardiology Unit, Civic Hospital, Brescia, Italy. carlofucci@libero.it
authors: Carlo
authors: C
authors: Fucci
authors: Pompilio
authors: P
authors: Faggiano
authors: Matilde
authors: M
authors: Nardi
authors: Antonio
authors: A
authors: D'Aloia
authors: Giuseppe
authors: G
authors: Coletti
authors: Giuseppe
authors: G
authors: De Cicco
authors: Leonardo
authors: L
authors: Latini
authors: Enrico
authors: E
authors: Vizzardi
authors: Roberto
authors: R
authors: Lorusso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D040181:Genetic Diseases, X-Linked / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000601:surgery*; D008945:Mitral Valve Prolapse / Q000000981:diagnostic imaging* / Q000601:surgery*; D058028:Research Report; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult