title: Effect of imidafenacin on nocturia and sleep disorder in patients with overactive bladder.
abstract: OBJECTIVE
  To evaluate the efficacy of imidafenacin on nocturia and sleep disorder in patients with overactive bladder (OAB).
  
  
  METHODS
  A prospective multicenter study of imidafenacin 0.1 mg twice daily for patients with OAB and nocturia was conducted. At baseline and at week 4 and 8, patients were assessed using the overactive bladder symptom score (OABSS), frequency volume charts (FVC) and the Pittsburgh Sleep Quality Index (PSQI).
  
  
  RESULTS
  Treatment with imidafenacin significantly improved OAB symptoms. Imidafenacin also improved PSQI, especially subjective sleep quality, sleep latency and daytime dysfunction. In FVC, the number of daytime voids and nighttime voids significantly decreased and average voided volume significantly increased after imidafenacin. Subanalysis of FVC based on the patients' age revealed that nocturnal polyuria was more often found in patients aged 75 years or over than in those aged under 75 years (79 vs. 55%, p < 0.05). Treatment with imidafenacin significantly reduced the nocturnal polyuria index only in patients aged 75 years or over.
  
  
  CONCLUSIONS
  Imidafenacin can improve nocturia and sleep disorder in patients with OAB. The efficacy of imidafenacin on nocturia is attributable to an increase in bladder capacity and a decrease in nocturnal urine volume. We conclude that imidafenacin is an effective and safe drug for nocturia in patients with OAB.
authors: Department of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Japan. nwada @ asahikawa-med.ac.jp
authors: Naoki
authors: N
authors: Wada
authors: Masaki
authors: M
authors: Watanabe
authors: Masafumi
authors: M
authors: Kita
authors: Seiji
authors: S
authors: Matsumoto
authors: Hiroaki
authors: H
authors: Osanai
authors: Satoshi
authors: S
authors: Yamaguchi
authors: Atsushi
authors: A
authors: Numata
authors: Makoto
authors: M
authors: Fujisawa
authors: Yuji
authors: Y
authors: Saga
authors: Kyokushin
authors: K
authors: Hou
authors: Hiromitsu
authors: H
authors: Iuchi
authors: Daisuke
authors: D
authors: Niibori
authors: Tatsuhiko
authors: T
authors: Kura
authors: Akihisa
authors: A
authors: Taniguchi
authors: Manabu
authors: M
authors: Kunieda
authors: Yasunobu
authors: Y
authors: Nakata
authors: Hidehiro
authors: H
authors: Kakizaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology; D053158:Nocturia / Q000188:drug therapy*; D011141:Polyuria / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D013997:Time Factors; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D007093:Imidazoles; D018727:Muscarinic Antagonists; C120953:imidafenacin