title: Preparation of microcapsules with multi-layers structure stabilized by chitosan and sodium dodecyl sulfate.
abstract: The microcapsules with oil core and multi-layers shell were developed from poly-cationic chitosan (CS) and anionic SDS in multistep electrostatic layer by layer deposition technique combined with oil in water emulsification process. The net charge of microcapsules determined by zeta potential indicated that microcapsules are highly positive charged because of poly-cationic nature of CS, and charge neutralization of microcapsules occurred after alkali treatment. The granulometry measurement showed increase in average diameter of microcapsules by alkali treatment suggesting swelling or formation of small aggregates. The morphology analysis of microcapsules by optical microscopy corroborated the results of granulometry, and diameter of microcapsules was found to be decreased in multistep process due to tight packing of layers in outer shell of microcapsules. The alkali treatment of microcapsules to solidify outer shell was optimized with 0.02 N NaOH to reduce microcapsules aggregation and gel formation by CS chains as found in optical micrographs.
authors: Univ Lille Nord de France, F-59000 Lille, France.
authors: Sudipta
authors: S
authors: Chatterjee
authors: Fabien
authors: F
authors: Salaün
authors: Christine
authors: C
authors: Campagne
authors: Suzy
authors: S
authors: Vaupre
authors: Alexandre
authors: A
authors: Beirão
mesh_terms: D000465:Algorithms; D000468:Alkalies / Q000494:pharmacology; D002214:Capsules / Q000737:chemistry* / Q000493:pharmacokinetics; D048271:Chitosan / Q000494:pharmacology*; D004345:Drug Industry / Q000379:methods; D004355:Drug Stability; D004655:Emulsions / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D055616:Microtechnology / Q000379:methods; D008954:Models, Biological; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D014867:Water / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000468:Alkalies; D002214:Capsules; D004655:Emulsions; D014867:Water; D012967:Sodium Dodecyl Sulfate; D048271:Chitosan