title: Successful kidney transplantation from a cadaveric donor unsuitable for other centers due to acute renal failure: a case report.
abstract: The demand for kidney transplantation due to improved recipient outcomes has stimulated surgeons to expand the criteria for usable donors, but still the use of organs from deceased donors with terminal acute renal failure is uncommon. We report 2 kidney transplant recipients from a cadaveric donor who was not accepted by other centers because of acute renal failure. The donor, a 24-year-old man with an intracerebral hemorrhage, displayed a serum creatinine (SCr) value of 0.6 mg/dL on hospital admission, which increased to 7.3 mg/dL on the fourth hospital day. After the diagnosis of brain death and refusal of the kidneys by other regional centers, we decided to transplant the 2 kidneys. Recipient 1, a 31-year-old man on an 11-year dialysis program, discontinued hemodialysis after 7 days of delayed graft function. The SCr level decreased gradually and was stable at 1.08 mg/dL on postoperative day (POD) 45. The contralateral graft was transplanted into a 30-year-old man (recipient 2) undergoing dialysis treatment for 7 years. After 10 days of delayed graft function, the SCr decreased gradually with continued hemodialysis until POD 24. The SCr level has been stable at 1.34 mg/dL on POD 52. At the end of the third month the SCr levels in recipients 1 and 2 were 1.1 mg/dL and 1.4 mg/dL, respectively. In conclusion, one may safely expand the donor pool with kidneys from deceased donors with acute renal failure (ARF) with good short-term outcomes.
authors: Department of Nephrology, Etlik Ihtisas Training and Education Hospital, Ankara, Turkey. aysebati@gmail.com
authors: A
authors: A
authors: Bilgic
authors: B
authors: B
authors: Erdogan
authors: A
authors: A
authors: Kali
authors: M
authors: M
authors: Buyukbakkal
authors: B
authors: B
authors: Eser
authors: B
authors: B
authors: Bozkurt
authors: M
authors: M
authors: Kilic
authors: M D
authors: MD
authors: Ayli
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001926:Brain Death; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D046148:Donor Selection; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology*; D008297:Male; D006435:Renal Dialysis; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003404:Creatinine