title: [Shortage and metabolic disturbance of magnesium in diabetic patients and significance of magnesium replacement therapy].
abstract: It is reported that shortage of oral magnesium intake increase the incidence of diabetes. In addition, magnesium replacement therapy improves insulin resistance and glycemic control. Low levels of magnesium in the venous blood induce the disturbances of auto-phosphylation on the insulin receptor and deteriorate insulin resistance. Since magnesium is closely related to evolution and development of metabolic syndrome including diabetes mellitus and so on, magnesium is expected as potentially effective ingredient of drug therapy in the future perspectives.
authors: First Department of Surgery, Kochi Medical School, Kochi University, Japan.
authors: Eri
authors: E
authors: Munekage
authors: Yuka
authors: Y
authors: Takezaki
authors: Kazuhiro
authors: K
authors: Hanazaki
mesh_terms: D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism* / Q000502:physiology; D008275:Magnesium Deficiency / Q000150:complications*; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism; D010766:Phosphorylation; D011972:Receptor, Insulin / Q000378:metabolism
chemical_list: D011972:Receptor, Insulin; D008274:Magnesium