title: Red Liriope platyphylla contains a large amount of polyphenolic compounds             which stimulate insulin secretion and suppress fatty liver formation through the             regulation of fatty acid oxidation in OLETF rats.
abstract: Red Liriope platyphylla (RLP) manufactured by two repeated steps (steaming and drying) stimulates the insulin secretion ability and glucose receptor signaling pathway in an animal model for type I diabetes. This study examined the levels of glucose and lipid metabolism-related factors in a useful animal model for type II diabetes with obesity following RLP treatment for 3 weeks to determine if RLP treatment affects the glucose concentration, insulin secretion and fatty acid oxidation. The following results were obtained: i) RLP contained a large amount of polyphenolic compounds; ii) insulin secretion was induced in RLP-treated OLETF rats, although there were no significant differences in body weight, glucose tolerance test and glucose concentration; iii) the RLP-treated OLETF rats showed a significant increase in adiponectin concentration but the concentration of triglyceride and LDL decreased compared to the vehicle-treated rats; iv) although the abdominal fat mass and adipocyte size did not change with RLP treatment, expression of the adipocyte marker genes and β-oxidation genes in fat tissue was recovered to the level of the LETO rats; v) fatty liver formation was reduced dramatically in the liver of the RLP-treated group compared to the vehicle-treated group; vi) the expression of adipocyte marker genes and the β-oxidation gene in the liver tissue were generally similar to those of the abdominal fat but PPAR-γ showed a reverse pattern in the RLP- and vehicle-treated OLETF rats. These results suggest that RLP may stimulate insulin secretion and a decrease in lipid in serum, and may also suppress fatty liver formation through the regulation of fatty acid oxidation. The data presented here highlight the possibility that RLP can be considered a candidate for the prevention or alleviation of obesity-related diseases.
authors: College of Natural Resources and Life Science, Pusan National                     University, Gyeongsangnam-do 627-706, Republic of Korea.
authors: Hye Ryun
authors: HR
authors: Lee
authors: Ji Eun
authors: JE
authors: Kim
authors: Jun Seo
authors: JS
authors: Goo
authors: Sun Il
authors: SI
authors: Choi
authors: In Sik
authors: IS
authors: Hwang
authors: Young Ju
authors: YJ
authors: Lee
authors: Hong Joo
authors: HJ
authors: Son
authors: Hee Seob
authors: HS
authors: Lee
authors: Jong Sup
authors: JS
authors: Lee
authors: Dae Youn
authors: DY
authors: Hwang
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects; D052242:Adiponectin / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism*; D005234:Fatty Liver / Q000378:metabolism / Q000517:prevention & control*; D005786:Gene Expression Regulation / Q000187:drug effects; D007328:Insulin / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D031424:Liriope Plant / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D059808:Polyphenols / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D020334:Rats, Inbred OLETF
chemical_list: D052242:Adiponectin; D005227:Fatty Acids; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols