title: C-reactive protein 1059G/C gene polymorphism, C-reactive protein levels and acute myocardial infarction.
abstract: OBJECTIVE
  High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker, predicting the occurrence of acute myocardial infarction (AMI). Genetic predisposition to high baseline CRP might account for a high risk of heart diseases. Our study aimed at investigating an association of CRP 1059G/C gene polymorphism with plasma CRP levels and AMI in Egyptian patients.
  
  
  METHODS
  Genotypes of 150 patients with AMI and 150 healthy sex and age-matched controls were analyzed using PCR-restriction fragment length polymorphism methods. hs-CRP concentrations were assessed.
  
  
  RESULTS
  There was no significant association between CRP 1095G/C polymorphism and AMI. However, individuals with GG genotype had significantly higher plasma CRP concentration than those with GC and CC genotypes, in both controls (3.82 ± 1.03 vs. 2.34 ± 0.7; P = 0.001) and patients with AMI (8.39 ± 2.6 vs. 6.67 ± 2.4; P = 0.005).
  
  
  CONCLUSIONS
  Our results revealed that CRP 1059G/C gene variation influences plasma CRP levels. Conversely, this polymorphism was not associated with the risk for AMI.
authors: Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors: Maivel H
authors: MH
authors: Ghattas
authors: Dina M
authors: DM
authors: Abo-Elmatty
authors: Azza Z
authors: AZ
authors: El-Eraki
mesh_terms: D000328:Adult; D054458:Amplified Fragment Length Polymorphism Analysis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004534:Egypt; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein