title: Perioperative levels of glutathione reductase in liver transplant recipients with hepatitis C virus cirrhosis.
abstract: Surgical intervention causes oxidative stress leading to an adaptive responses by the body. To evaluate changes in the defense capacity of antioxidant enzymes, we determined the activity of glutathione reductase (GR) levels among liver transplant recipients with due to hepatitis C virus cirrhosis. The study was performed in 22 patients (16 males and 6 females) of average ages 52.63 ± 5.49 years for males and 59.67 ± 5.65 years for females. Blood samples for glutathione reductase activity were drawn on admission before as well as at 1, 6, and 12 h and 1, 2, 3, 5 and 7 days after the liver transplantation. Perioperative glutathione reductase levels were significant (P = .014) over the period using Bonferroni tests. GR activity reached a maximum (15.6112 ± 6.56035 nmol/mg protein) at 3 days after liver transplantation (T3d) (P = .001). The increased GR activity values detected perioperatively indicated scavenging of reactive oxygen species generated after liver transplantation of hepatitis C virus cirrhosis patients.
authors: General and Digestive Surgery Service, Virgen de las Nieves University Hospital, Granada, Spain.
authors: T
authors: T
authors: Villegas
authors: C
authors: C
authors: Olmedo
authors: K
authors: K
authors: Muffak-Granero
authors: A
authors: A
authors: Comino
authors: D
authors: D
authors: Garrote
authors: P
authors: P
authors: Bueno
authors: J-A
authors: JA
authors: Ferrón
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005980:Glutathione Reductase / Q000097:blood*; D006526:Hepatitis C / Q000097:blood / Q000150:complications / Q000201:enzymology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000201:enzymology* / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D057234:Preoperative Period; D017382:Reactive Oxygen Species / Q000378:metabolism; D013030:Spain; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D005980:Glutathione Reductase