title: FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression.
abstract: FERM family proteins have been known to play an important role in tumor progression. FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an unknown function protein. Here, we reported that FRMD5 localized at the cell adherens junction and formed a molecular complex with p120-catenin through its C-terminal region. Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor suppressive effect. These findings indicated that FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression.
authors: Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing, China.
authors: Tao
authors: T
authors: Wang
authors: Xuelian
authors: X
authors: Pei
authors: Jun
authors: J
authors: Zhan
authors: Jinxia
authors: J
authors: Hu
authors: Yu
authors: Y
authors: Yu
authors: Hongquan
authors: H
authors: Zhang
mesh_terms: D000818:Animals; D001483:Base Sequence; D051177:Catenins / Q000502:physiology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D005260:Female; D055785:Gene Knockdown Techniques; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D010802:Phylogeny; D054730:Protein Interaction Domains and Motifs; D034741:RNA, Small Interfering / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000095002:Delta Catenin
chemical_list: D051177:Catenins; D003598:Cytoskeletal Proteins; D034741:RNA, Small Interfering; D025521:Tumor Suppressor Proteins; D000095002:Delta Catenin