title: [A case of mantle cell lymphoma with meningioma].
abstract: Mantle cell lymphoma (MCL) is an uncommon type of gastrointestinal lymphoma. MCL is a distinct subtype of B-cell non-Hodgkin lymphomas. The major subtype of MCL is characterized by the presence of multiple lymphomatous polyposis (MLP), in which multiple polyps are observed along the gastrointestinal tract. The malignant cells express pan B-cell marker and the T-cell marker cluster of differentiation 5. The chromosomal translocation t(11;14)(q13;q32) that causes cyclin D1 overexpression is commonly observed on the cytogenetic analysis of MCL. Survival improvement has recently been achieved for patient with MCL by the successful introduction of monoclonal antibodies and dose-intensified approaches for treatment, including autologous stem cell transplantation strategies. Some reports suggest that there is an increased incidence of second malignancies in patients with MCL or lymphoma. We report a case of MCL involving the colon; the patient was a 60-year-old man who complained of low abdominal discomfort during defecation. During the workup, a meningioma was unexpectedly discovered. On analysis, the tumor was found to be a t(11;14)-negative and non-MLP-type MCL.
authors: Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors: Eui Sik
authors: ES
authors: Kim
authors: Pyung Gohn
authors: PG
authors: Goh
authors: Yun Jeung
authors: YJ
authors: Kim
authors: Su Youn
authors: SY
authors: Lee
authors: Hee Seok
authors: HS
authors: Moon
authors: Jae Kyu
authors: JK
authors: Sung
authors: Byung Seok
authors: BS
authors: Lee
authors: Hyun Yong
authors: HY
authors: Jeong
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D019938:Cyclin D1 / Q000378:metabolism; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008579:Meningioma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014178:Translocation, Genetic
chemical_list: D019938:Cyclin D1