title: [Preparation and physiochemical properties of curcumin-loaded lipid cubic liquid crystalline nanoparticles].
abstract: OBJECTIVE
  To prepare curcumin-loaded lipid cubic liquid crystalline nanoparticles and evaluate its physiochemical properties.
  
  
  METHODS
  The nanoparticles were prepared using hot and high-pressure homogenization. The prescription and preparation process were optimized by uniform design with drug loading and entrapment efficiency as indexes.
  
  
  RESULTS
  The nanoparticles were spherical under transmission electron microscope (TEM) with average particle size of 176.1 nm, zeta potential of -25.19 mV, average drug loading of (1.5 +/- 0.2)% and entrapment efficiency of (95 +/- 1.8)%. The release equation: In (1-Q) = -0.0251t-0.0075. The cumulative release percentage was 60% at 36 h in vitro.
  
  
  CONCLUSIONS
  The obtained curcumin-loaded lipid cubic liquid crystalline nanoparticles shows high entrapment efficiency and good sustain release property.
authors: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. suxunz@yahoo.com.cn
authors: Xun
authors: X
authors: Su
authors: Xiu-li
authors: XL
authors: He
authors: Xiu-ju
authors: XJ
authors: Liu
authors: Jing-yan
authors: JY
authors: Guo
authors: Guang-xi
authors: GX
authors: Zhai
mesh_terms: D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D005989:Glycerides / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D009829:Oleic Acids / Q000737:chemistry; D010316:Particle Size; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005989:Glycerides; D008081:Liposomes; D009829:Oleic Acids; C005953:monoolein; D003474:Curcumin