title: Age at last birth in relation to risk of endometrial cancer: pooled analysis in the epidemiology of endometrial cancer consortium.
abstract: Childbearing at an older age has been associated with a lower risk of endometrial cancer, but whether the association is independent of the number of births or other factors remains unclear. Individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium were pooled. A total of 8,671 cases of endometrial cancer and 16,562 controls were included in the analysis. After adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (P(trend) < 0.0001). The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95% confidence interval: 0.85, 0.90). Women who last gave birth at 40 years of age or older had a 44% decreased risk compared with women who had their last birth under the age of 25 years (95% confidence interval: 47, 66). The protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II). No effect modification was observed by body mass index, parity, or exogenous hormone use. In this large pooled analysis, late age at last birth was independently associated with a reduced risk of endometrial cancer, and the reduced risk persisted for many years.
authors: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. vsetiawa@usc.edu
authors: Veronica Wendy
authors: VW
authors: Setiawan
authors: Malcolm C
authors: MC
authors: Pike
authors: Stalo
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authors: Karageorgi
authors: Sandra L
authors: SL
authors: Deming
authors: Kristin
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authors: Anderson
authors: Leslie
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authors: Bernstein
authors: Louise A
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authors: Brinton
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authors: James R
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authors: Cerhan
authors: Wendy
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authors: Cozen
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authors: Chen
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authors: Doherty
authors: Jo L
authors: JL
authors: Freudenheim
authors: Marc T
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authors: Goodman
authors: Susan E
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authors: Hankinson
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authors: Lacey
authors: Xiaolin
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authors: Liang
authors: Jolanta
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authors: Lissowska
authors: Lingeng
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authors: Lu
authors: Galina
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authors: Lurie
authors: Thomas
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authors: Mack
authors: Rayna K
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authors: Matsuno
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authors: McCann
authors: Kirsten B
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authors: Moysich
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authors: Radhai
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authors: Rastogi
authors: Timothy R
authors: TR
authors: Rebbeck
authors: Harvey
authors: H
authors: Risch
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authors: K
authors: Robien
authors: Catherine
authors: C
authors: Schairer
authors: Xiao-Ou
authors: XO
authors: Shu
authors: Amanda B
authors: AB
authors: Spurdle
authors: Brian L
authors: BL
authors: Strom
authors: Pamela J
authors: PJ
authors: Thompson
authors: Giske
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authors: Ursin
authors: Penelope M
authors: PM
authors: Webb
authors: Noel S
authors: NS
authors: Weiss
authors: Nicolas
authors: N
authors: Wentzensen
authors: Yong-Bing
authors: YB
authors: Xiang
authors: Hannah P
authors: HP
authors: Yang
authors: Herbert
authors: H
authors: Yu
authors: Pamela L
authors: PL
authors: Horn-Ross
authors: Immaculata
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authors: De Vivo
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008423:Maternal Age; D016017:Odds Ratio; D010298:Parity; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D012307:Risk Factors; D014481:United States / Q000453:epidemiology