title: ADAMTS5: A New Player in the Vascular Field.
abstract: This Commentary highlights the article by Kumar et al, showing that ADAMTS5 suppresses tumor growth by down-regulating other angiogenesis-inducing factors in addition to VEGF and that the central TSR1 domain of ADAMTS5 is required in this function.
authors: Department of Dermatology, University of Turku, Finland.
authors: Liisa
authors: L
authors: Nissinen
authors: Veli-Matti
authors: VM
authors: Kähäri
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000071116:ADAMTS5 Protein; D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; C022474:proteoglycan-degrading metalloendopeptidases; D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human; D008666:Metalloendopeptidases