title: Reorientation deficits are associated with amnestic mild cognitive impairment.
abstract: OBJECTIVE
  Spatial memory can be impaired in amnestic mild cognitive impairment (aMCI). The present study investigates categorical spatial memory deficits using a virtual navigation-based reorientation task.
  
  
  METHODS
  Twenty-eight amnestic single domain and 23 amnestic multiple domain patients were compared with 53 healthy elderly controls on the performance of the virtual reorientation test (VReoT).
  
  
  RESULTS
  The reorientation performance of participants in both aMCI groups was significantly worse than that of controls suggesting that VReoT detects spatial memory deficits. No significant difference emerged between the 2 groups of patients. A subsequent receiver-operating characteristic analysis showed that a score of 8 had a sensitivity of 80.4% and a specificity of 94.3% (area under the curve = 0.90).
  
  
  CONCLUSIONS
  The VReoT seemed to be accurate in differentiating patients with aMCI from controls and may represent an evaluation supplement for spatial memory deficits in prodromal stages of Alzheimer's dementia.
authors: Department of Psychology and Pedagogical and Educational Sciences, University of Bari, Bari, Italy.
authors: Alessandro O
authors: AO
authors: Caffò
authors: Maria F
authors: MF
authors: De Caro
authors: Luciana
authors: L
authors: Picucci
authors: Alessandra
authors: A
authors: Notarnicola
authors: Annalisa
authors: A
authors: Settanni
authors: Paolo
authors: P
authors: Livrea
authors: Giulio E
authors: GE
authors: Lancioni
authors: Andrea
authors: A
authors: Bosco
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity