title: Peripheral (limb) myokymic discharges in motor neuron disease.
abstract: We present the case of a 28-year-old gentleman who presented with weakness and wasting in the right arm. He complained about painful cramps in his left leg but there were no sensory, visual or swallowing problems. Neurological examination was significant for asymmetric weakness of both upper and lower limbs and deep tendon reflexes were asymmetrically brisk. Initial laboratory investigations, MRI brain and MRI spine were normal. Electromyography revealed active denervation and chronic neurogenic motor unit action potential. Myokymic discharges were noted in the left deltoid muscle.
authors: Department of Medicine, Aga Khan University Hospital, Karachi, Sindh, Pakistan. drjunaid.akhtar@hotmail.com
authors: Javeria
authors: J
authors: Rauf
authors: Junaid
authors: J
authors: Akhtar
authors: Bhojo Assumal
authors: BA
authors: Khealani
authors: Liaquat
authors: L
authors: Ali
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use*; D001418:Baclofen / Q000627:therapeutic use; D057645:Deltoid Muscle / Q000503:physiopathology*; D037001:Directive Counseling; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D009120:Muscle Cramp / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D009128:Muscle Spasticity / Q000188:drug therapy / Q000503:physiopathology*; D020385:Myokymia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D011803:Quinine / Q000627:therapeutic use; D019782:Riluzole / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D009125:Muscle Relaxants, Central; D019782:Riluzole; D011803:Quinine; D001418:Baclofen