title: Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma.
abstract: BACKGROUND
  Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls.
  
  
  METHODS
  HLA types of all German Caucasian patients with advanced ESFT and available HLA-A, -B and -DR data registered in the European Group for Blood and Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA types of healthy German stem cell donors (control group, n=8 862 for single HLA frequencies and n=8 839 for allele combinations). Study group patients had been immuno-typed due to eligibility for allogeneic stem cell transplantation for high risk of treatment failure, and thus constituted a selected subgroup of ESFT patients.
  
  
  RESULTS
  After Bonferroni correction for multiple testing (PC), phenotype frequencies of HLA-A24 remained significantly higher in the study group compared to controls (PC<0.05). Furthermore, several HLA combinations were significantly more frequent in the study group compared to controls (all PC<0.05).
  
  
  CONCLUSIONS
  We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.
authors: Department of Pediatrics and Pediatric Oncology Center, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. uwe.thiel@lrz.tum.de
authors: U
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authors: Thiel
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authors: Wolf
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authors: Wawer
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authors: Blaeschke
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authors: TG
authors: Grunewald
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authors: von Lüttichau
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authors: Klingebiel
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authors: Bader
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authors: Borkhardt
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authors: Schlegel
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authors: Eyrich
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authors: Gruhn
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authors: Ehninger
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authors: Koscielniak
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authors: Klein
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authors: Sykora
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authors: Holler
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authors: Mauz-Körholz
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authors: Woessmann
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authors: Richter
authors: A H
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authors: Schmidt
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authors: Peters
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authors: Dirksen
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authors: Jürgens
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authors: Bregni
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authors: Burdach
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D002648:Child; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005858:Germany; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens