title: [An analysis on biomedical effects of bipolar electric pulses at different central frequency].
abstract: Adopting the cell model of multilayer spherical symmetry and the circuit analysis, the present paper gives the calculated results of the voltages on each of several parts of malignant Tonsillar B-cells and Jurkat T lymphocytes when the first-order Gaussian pulses at different central frequency apposed on them. The relationship between the central frequency and the transmembrane voltages of plasma membrane is also given. The optimum frequency causing electroporation in nuclear envelope is given as well. The paper discusses the reasons of electroporation in membrane and DNA degradation in nuclear. The work provides a reference for usage of transient bipolar electric pulses in cancer treatment.
authors: Physical Electronics College, University of Electronic Science and Technology of China, Chengdu 610054, China. yafang-tan@163.com
authors: Yafang
authors: Y
authors: Tan
authors: Hongchun
authors: H
authors: Yang
authors: Jun
authors: J
authors: Xu
authors: Yi
authors: Y
authors: Zhang
authors: Minghe
authors: M
authors: Wu
authors: Heng
authors: H
authors: Zou
mesh_terms: D017209:Apoptosis / Q000528:radiation effects*; D001402:B-Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000502:physiology; D004574:Electromagnetic Fields; D018274:Electroporation / Q000379:methods*; D006801:Humans; D019169:Jurkat Cells; D009685:Nuclear Envelope / Q000473:pathology / Q000528:radiation effects*