title: Evaluation of the antioxidant capacity of synthesized coumarins.
abstract: Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH(•)) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Damiana R
authors: DR
authors: Vianna
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Guilherme
authors: G
authors: Bubols
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Gabriela
authors: G
authors: Meirelles
authors: Institute of Chemistry, Federal University of Rio de Janeiro, UFRJ, Bloco A, Cidade Universitária, 21941-909, Rio de Janeiro, RJ, Brazil.
authors: Bárbara V
authors: BV
authors: Silva
authors: Post-Graduate Program in Physiological Sciences, Comparative Animal Physiology, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Av Itália km 8 s/n, 96201-900, Rio Grande, RS, Brazil.
authors: Alessandra
authors: A
authors: Da Rocha
authors: Institute of Chemistry, Universidade Federal Fluminense, UFF, Outeiro de São João Batista, s/n, Campus do Valonguinho Centro, 24020-150, Niterói, RJ, Brazil.
authors: Maurício
authors: M
authors: Lanznaster
authors: Post-Graduate Program in Physiological Sciences, Comparative Animal Physiology, Institute of Biological Sciences, Federal University of Rio Grande, FURG, Av Itália km 8 s/n, 96201-900, Rio Grande, RS, Brazil.
authors: José Maria
authors: 0000-0002-9463-3049
authors: JM
authors: Monserrat
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Solange Cristina
authors: SC
authors: Garcia
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Gilsane
authors: G
authors: Von Poser
authors: Post-Graduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
authors: Vera Lucia
authors: VL
authors: Eifler-Lima
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry*; D014468:Umbelliferones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010545:Peroxides; D014468:Umbelliferones; C049375:perhydroxyl radical; C007628:esculetin