title: Current concepts and significance of estrogen receptor β in prostate cancer.
abstract: An increasing amount of evidence points at important roles for estrogen receptors in prostate carcinogenesis and progression. Of the two estrogen receptors, estrogen receptor β is the most prominent within the prostate gland. Although there is much yet to be known, the findings from the discovery of the receptor in 1996 until now point at a role of the receptor in maintaining differentiation and reducing cellular proliferation in the prostate. Moreover, estrogen receptor β is the main target for phytoestrogens, perhaps at least partially explaining the difference in incidence of prostate cancer in the Western world compared to Asia where the intake of soy-based, phytoestrogen-rich food is higher. The tumor suppressive capability of estrogen receptor β makes it a promising drug target for the treatment and prevention of prostate cancer. This review will focus on different aspects of estrogen receptor signaling and prostate cancer.
authors: Department of Oncology and Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
authors: Johan
authors: J
authors: Hartman
authors: Anders
authors: A
authors: Ström
authors: Jan-Åke
authors: JÅ
authors: Gustafsson
mesh_terms: D000818:Animals; D018450:Disease Progression; D047629:Estrogen Receptor beta / Q000378:metabolism*; D006801:Humans; D008297:Male; D048789:Phytoestrogens / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy
chemical_list: D047629:Estrogen Receptor beta; D048789:Phytoestrogens