title: Glycan-targeted virus-like nanoparticles for photodynamic therapy.
abstract: Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.
authors: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
authors: Jin-Kyu
authors: JK
authors: Rhee
authors: Michael
authors: M
authors: Baksh
authors: Corwin
authors: C
authors: Nycholat
authors: James C
authors: JC
authors: Paulson
authors: Hiroaki
authors: H
authors: Kitagishi
authors: M G
authors: MG
authors: Finn
mesh_terms: D017908:Allolevivirus / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D057930:Click Chemistry; D006224:Cricetinae; D049452:Green Fluorescent Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000378:metabolism; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism; D026082:Singlet Oxygen
chemical_list: C497867:CD22 protein, human; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011134:Polysaccharides; D011166:Porphyrins; D051918:Sialic Acid Binding Ig-like Lectin 2; D012794:Sialic Acids; D049452:Green Fluorescent Proteins; D026082:Singlet Oxygen