title: Relationship between dyslipidemia and gene polymorphism in Tibetan population.
abstract: OBJECTIVE
  To investigate the relationship between SNPs reported in previous studies and the blood lipid level in the Tibetan population.
  
  
  METHODS
  Random cluster sampling was employed in 5 areas (Lhasa, Shigatse, Shannan, Nagqu, and Nyingchi). The levels of cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from blood samples were determined and DNA was extracted for genotyping and statistical analyses.
  
  
  RESULTS
  Among 1 318 subjects aged >18 years enrolled in this study, 367 had dyslipidemia with a prevalence of 27.8%, of whom dyslipidemia males accounted for 33.1% and dyslipidemia females -24.5%. Results of the correlation analysis between all SNPs and TG showed that the SNPs of rs714052 and rs964184 were related to the serum TG level. Subjects with rs714052 CC genotype had the lowest TG level, and the highest TG level was found in those with rs714052 TT genotype. The serum TG level in individuals with TC genotype lied in between the above two population groups. Subjects with rs964184 CC genotype had the lowest TG level, and the highest serum TG level was noted in those with rs964184 GG genotype.
  
  
  CONCLUSIONS
  Several SNPs were found to be related to the serum TG level in the Tibetan population. The APOA5 gene and MLXIPL gene may be closely associated with the serum TG level in this ethnic population group.
authors: Institute of Tuberculosis, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China.
authors: Ling Xia
authors: LX
authors: Zhang
authors: Ying
authors: Y
authors: Sun
authors: Yu
authors: Y
authors: Liang
authors: Kui
authors: K
authors: Li
authors: Yong
authors: Y
authors: Chen
authors: Gusanglamu
authors: Jian
authors: J
authors: Wang
mesh_terms: D050171:Dyslipidemias / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018609:Tibet / Q000453:epidemiology
chemical_list: D008055:Lipids