title: Aberrant expression levels of MTA1 and RECK in nasopharyngeal carcinoma: association with metastasis, recurrence, and prognosis.
abstract: OBJECTIVE
  We investigated the expression and clinical value of MTA1 and RECK genes in patients with nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  We examined MTA1 and RECK expression in nasopharyngeal tissue from patients with chronic nasopharyngitis, lymph nodes with metastasis of NPC, and primary NPC tumor tissue by means of in situ hybridization and analyzed their correlation with the clinicopathologic features of NPC.
  
  
  RESULTS
  The positive expression of MTA1 in the NPC tissues and metastatic lymph nodes was significantly higher than that in the chronic nasopharyngitis tissues (p < 0.05). The positive expression of RECK in the NPC tissues and metastatic lymph nodes was significantly lower than that in the chronic nasopharyngitis tissues (p < 0.05). The RECK expression level was inversely correlated with the MTA1 expression level in the NPC tissues (p < 0.05). The increased MTA1 and decreased RECK expressions in the NPC tissues had no association with gender, age, T-stage, or clinical stage (p > 0.05). However, they had a positive correlation with cervical lymph node metastasis, tumor recurrence, and 5-year overall survival rate of the patients with NPC (p < 0.05). Moreover, multivariate analysis showed that MTA1 and RECK expressions were independent prognostic factors for survival (p < 0.05).
  
  
  CONCLUSIONS
  The conversely abnormal expression levels of MTA1 and RECK may be collectively involved in progression of malignancies and may serve as molecular predictors for metastasis, recurrence, and prognosis of NPC.
authors: Dept of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Xiamen University, No. 209 Hubin South Road, Xiamen, Fujian 361004, China.
authors: Yan Fei
authors: YF
authors: Deng
authors: Dong Ni
authors: DN
authors: Zhou
authors: Chun Sheng
authors: CS
authors: Ye
authors: Liang
authors: L
authors: Zeng
authors: Ping
authors: P
authors: Yin
mesh_terms: D002277:Carcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics*; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D009304:Nasopharyngitis / Q000235:genetics / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics*; D015996:Survival Rate; D015534:Trans-Activators
chemical_list: D058851:GPI-Linked Proteins; C089320:MTA1 protein, human; C115460:RECK protein, human; D012333:RNA, Messenger; D012097:Repressor Proteins; D015534:Trans-Activators; D006655:Histone Deacetylases