title: Evaluation of collagen-based membranes for guided bone regeneration, by three-dimensional computerized microtomography.
abstract: OBJECTIVE
  The aim of this study was to evaluate the use of a collagen-based membrane compared with no treatment on guided bone regeneration by 3-dimensional computerized microtomography (μCT).
  
  
  METHODS
  Defects were created between the mesial and distal premolar roots of the second and third premolars (beagle dogs; n = 8). A collagen-based membrane (Vitala; Osteogenics Biomedical Inc., TX, USA) was placed in one of the defects (membrane group; n = 16), and the other was left untreated (no-membrane group; n = 16). Left and right sides provided healing samples for 2 and 16 weeks. Three-dimensional bone architecture was acquired by μCT and categorized as fully regenerated (F, bone height and width) or nonregenerated (N).
  
  
  RESULTS
  Chi-square tests (95% level of significance) showed that tooth did not have an effect on outcome (P = .5). Significantly higher F outcomes were observed at 16 weeks than 2 weeks (P = .008) and in membrane group than in no-membrane group (P = .008).
  
  
  CONCLUSIONS
  The collagen-based membrane influenced bone regeneration at the furcation.
authors: Department of Biomaterials and Biomimetics, New York University, New York, NY, USA.
authors: Paulo Guilherme
authors: PG
authors: Coelho
authors: Gabriela
authors: G
authors: Giro
authors: Wanki
authors: W
authors: Kim
authors: Rodrigo
authors: R
authors: Granato
authors: Charles
authors: C
authors: Marin
authors: Estevam Augusto
authors: EA
authors: Bonfante
authors: Samara
authors: S
authors: Bonfante
authors: Thomas
authors: T
authors: Lilin
authors: Marcelo
authors: M
authors: Suzuki
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D003094:Collagen / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D017823:Furcation Defects / Q000000981:diagnostic imaging / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008567:Membranes, Artificial; D055114:X-Ray Microtomography
chemical_list: D008567:Membranes, Artificial; D003094:Collagen