title: Skin and soft tissue infections among HIV-infected persons in the late combination antiretroviral therapy era.
abstract: Skin and soft tissue infections (SSTIs) occur at higher rates among HIV-infected persons, but current trends and risk factors are largely undefined. We evaluated SSTIs among a prospective cohort of HIV-infected persons during the late combination antiretroviral therapy (cART) era (2006-2010). Of the 1918 HIV-infected persons evaluated, 379 (20%) developed an SSTI during a median of 3.7 years of follow-up; of these, 118 (31%) developed at least one recurrent SSTI. The incidence rate of SSTIs was 101 (95% confidence interval [CI] 93-109) cases per 1000 person-years, and rates did not significantly change during the study period. Compared with not receiving cART and having an HIV RNA level >1000 copies/mL, patients receiving cART with an HIV RNA level <1000 copies/mL had a reduced risk of an SSTI (hazard ratio 0.64, 95% CI 0.48-0.86, P < 0.01). In summary, initial and recurrent SSTIs are common among HIV-infected persons, and HIV control is associated with a lower risk of SSTIs.
authors: Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. nancy.crum@med.navy.mil
authors: N F
authors: NF
authors: Crum-Cianflone
authors: G
authors: G
authors: Grandits
authors: A
authors: A
authors: Weintrob
authors: A
authors: A
authors: Ganesan
authors: B
authors: B
authors: Agan
authors: M
authors: M
authors: Landrum
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008889:Military Personnel / Q000706:statistics & numerical data; D011446:Prospective Studies; D012307:Risk Factors; D012874:Skin Diseases, Infectious / Q000453:epidemiology / Q000821:virology*; D018461:Soft Tissue Infections / Q000453:epidemiology / Q000821:virology*; D014481:United States / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents