title: Cutaneous side-effects of epidermal growth factor receptor-tyrosine kinase inhibitor (TKI) in the treatment of lung cancer: description and its management.
abstract: Epidermal growth factor receptor (EGFR)--tyrosine kinase inhibitors (TKI) like erlotinib and gefitinib have been approved as monotherapy for the treatment of patients with locally advanced or metastatic non small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen. The use of EGFR-TKI is associated with unique and dramatic dermatologic side effects. We report 2 patients with NSCLC developing a typical acneiform (papulo-pustular) eruption shortly after initiation of EGFR-TKI.
authors: Department of Respiratory Medicine, Hospital Pulau Pinang, Penang, Malaysia. ongchookhoon@yahoo.com
authors: C K
authors: CK
authors: Ong
authors: W C
authors: WC
authors: Tan
authors: L C
authors: LC
authors: Chan
authors: M
authors: M
authors: Abdul Razak
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D018450:Disease Progression; D003875:Drug Eruptions / Q000188:drug therapy*; D000069347:Erlotinib Hydrochloride; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000009:adverse effects*; D011799:Quinazolines / Q000009:adverse effects*
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; D000077156:Gefitinib