title: [Analysis of prescriptions associated to hormone replacement therapy in Midi-Pyrénées region].
abstract: The aim of the present study was 1- to describe hormone replacement therapy (HRT)           prescription in Midi-Pyrénées region (South West France) and 2- to compare the           prescriptions of associated drugs to those of women who took HRT with prescriptions to           women who did not take HRT. From 2004 to 2008, HRT prescription decreased for women aged           50 to 59 years in Midi-Pyrénées: 13.95% to 10.33% estradiol/progestin association           consumers. During the first 6 months of 2008, 20,161 women took the association           estradiol/progestin. Transdermal/percutaneous forms of estradiol (71.21%) and natural           progesterone were mainly prescribed. The number of different dispensed drugs was           significantly higher in the HRT group: 5.18 versus 2.82 in the control group (p <           0.0001). All classes were concerned except antineoplastic drugs and immunomodulators,           drugs for diabetes and raloxifene which were more prescribed to controls. In the period of           the study, 7,035 patients took estrogen alone (25.87% of HRT consumers). The same           phenomena were observed in this group. Women exposed to HRT in Midi-Pyrénées, great           consumers of drugs, represent a population who require particular medical supervision,           because of the risks of HRT and pathologies and/or numerous associated drugs.
authors: Service de Pharmacologie Clinique, Faculté de Médecine, Université de Toulouse, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Centre Hospitalo-universitaire, Toulouse, France. f.jegu@hotmail.fr
authors: Florence
authors: F
authors: Gass-Jégu
authors: Christine
authors: C
authors: Damase-Michel
authors: Caroline
authors: C
authors: Hurault-Delarue
authors: Robert
authors: R
authors: Bourrel
authors: Jean-Louis
authors: JL
authors: Montastruc
mesh_terms: D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004363:Drug Utilization; D004958:Estradiol / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data* / Q000639:trends*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007349:Insurance, Health, Reimbursement / Q000706:statistics & numerical data; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D017698:Postmenopause; D011372:Progestins / Q000627:therapeutic use
chemical_list: D011372:Progestins; D004958:Estradiol