title: Immunoinflammation and functional gastrointestinal disorders.
abstract: Functional gastrointestinal disorders (FGIDs) are a group of conditions characterized by the dysfunction of the gastrointestinal (GI) tract. Although the specific pathogenesis of FGIDs is unclear, several theories have been proposed to explain the symptoms. Abnormal GI motility and visceral hypersensitivity have always been considered to be the main physiopathologic basis of FGIDs, and FGIDs related to psychomental disorders have also caused a major social concern. In recent years, a growing number of researches have proved that cytokines have a significant influence on GI motility, and the role of cytokines in FGIDs has aroused more and more attention. In this article, we discuss the interaction between immunoinflammation and FGIDs, and make an overview of current studies.
authors: Department of Gastroenterology, RenMin Hospital of WuHan University, HuBei Province, China. kaimingchen@163.com
authors: Ming-Kai
authors: MK
authors: Chen
authors: Shu-Zhong
authors: SZ
authors: Liu
authors: Li
authors: L
authors: Zhang
mesh_terms: D016207:Cytokines / Q000502:physiology; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D056885:Interstitial Cells of Cajal / Q000502:physiology; D001523:Mental Disorders / Q000209:etiology / Q000378:metabolism / Q000473:pathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators