title: Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes.
abstract: OBJECTIVE
  The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied.
  
  
  METHODS
  Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated.
  
  
  RESULTS
  Lower BIC was observed in DR (35.35 ± 18.04) compared with the HR (69.07 ± 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p ≥ 0.21).
  
  
  CONCLUSIONS
  HBOT, either before or after implantation, increased the BIC in DR to the level of HR.
authors: Department of Periodontology, School of Dentistry, Pontific Catholic University of Minas Gerais, Belo Horizonte, Brazil.
authors: Peterson Antônio Dutra
authors: PA
authors: Oliveira
authors: Alcione Maria Soares Dutra
authors: AM
authors: Oliveira
authors: Aletheia Buosi
authors: AB
authors: Pablos
authors: Fernando Oliveira
authors: FO
authors: Costa
authors: Gerluza Aparecida Borges
authors: GA
authors: Silva
authors: Jean Nunes Dos
authors: JN
authors: Santos
authors: Patricia Ramos
authors: PR
authors: Cury
mesh_terms: D000496:Alloxan; D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D005269:Femur / Q000502:physiology / Q000601:surgery; D006931:Hyperbaric Oxygenation; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000502:physiology
chemical_list: D000496:Alloxan