title: Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: synthesis, SAR and biological evaluation.
abstract: Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. Several series of β-amino amide containing piperazine derivatives have been prepared and evaluated as a inhibitor of DPP4. Finally compound 5m was selected for further evaluation.
authors: Dong-A Pharm. Co., Ltd, 47-5, Sanggal-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-905, Republic of Korea.
authors: Heung Jae
authors: HJ
authors: Kim
authors: Woo Young
authors: WY
authors: Kwak
authors: Jong Pil
authors: JP
authors: Min
authors: Si Young
authors: SY
authors: Sung
authors: Ha Dong
authors: HD
authors: Kim
authors: Mi Kyung
authors: MK
authors: Kim
authors: Hae Sun
authors: HS
authors: Kim
authors: Kyung Jin
authors: KJ
authors: Park
authors: Moon Ho
authors: MH
authors: Son
authors: Soon Hoe
authors: SH
authors: Kim
authors: Bong Jin
authors: BJ
authors: Lee
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004285:Dogs; D005951:Glucose Tolerance Test; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008958:Models, Molecular; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000577:Amides; D001786:Blood Glucose; D054873:Dipeptidyl-Peptidase IV Inhibitors; D010879:Piperazines; D018819:Dipeptidyl Peptidase 4