title: Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring.
abstract: A collection of fungal isolates was obtained from a complex microbial mat, which occupied an iron-rich freshwater spring that feeds into Clear Creek, Golden, Colorado, USA. Two of the fungal isolates, a Glomeromycete (possible Entrophospora sp.) and a Dothideomycete (possible Phaeosphaeria sp.), were investigated for bioactive secondary metabolites. In total, six new compounds consisting of clearanols A-E (5, 6, 10-12) and disulochrin (7) were purified and their structures were determined. Disulochrin exhibited modest antibacterial activity against methicillin-resistant Staphylococcus aureus, whereas clearanol C showed weak inhibitory activity against Candida albicans biofilm formation.
authors: Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center 101 Stephenson Parkway, Room 1000, University of Oklahoma, Norman, Oklahoma, 73019-5251, USA.
authors: Alexandra L
authors: AL
authors: Gerea
authors: Katie M
authors: KM
authors: Branscum
authors: Jarrod B
authors: JB
authors: King
authors: Jianlan
authors: J
authors: You
authors: Douglas R
authors: DR
authors: Powell
authors: Andrew N
authors: AN
authors: Miller
authors: John R
authors: JR
authors: Spear
authors: Robert H
authors: RH
authors: Cichewicz