title: Enhancing tsetse fly refractoriness to trypanosome infection--a new IAEA coordinated research project.
abstract: To date, IAEA-supported Sterile Insect Technique (SIT) projects for tsetse and trypanosomiasis control have been in areas without human sleeping sickness, but future projects could include areas of actual or potential human disease transmission. In this context it would be imperative that released sterile tsetse flies are incompetent to transmit the disease-causing trypanosome parasite. Therefore, development of tsetse fly strains refractory to trypanosome infection is highly desirable as a simple and effective method of ensuring vector incompetence of the released flies. This new IAEA Coordinated Research Project (CRP) focuses on gaining a deeper knowledge of the tripartite interactions between the tsetse fly vectors, their symbionts and trypanosome parasites. The objective of this CRP is to acquire a better understanding of mechanisms that limit the development of trypanosome infections in tsetse and how these may be enhanced.
authors: Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium. jvdabbeele@itg.be
authors: Jan
authors: J
authors: Van Den Abbeele
authors: Kostas
authors: K
authors: Bourtzis
authors: Brian
authors: B
authors: Weiss
authors: Celia
authors: C
authors: Cordón-Rosales
authors: Wolfgang
authors: W
authors: Miller
authors: Adly M M
authors: AM
authors: Abd-Alla
authors: Andrew
authors: A
authors: Parker
mesh_terms: D000818:Animals; D006090:Gram-Negative Bacteria; D006801:Humans; D007303:Insect Vectors; D010572:Pest Control, Biological / Q000379:methods*; D013559:Symbiosis; D014353:Trypanosomiasis, African / Q000517:prevention & control* / Q000635:transmission; D014370:Tsetse Flies / Q000382:microbiology*