title: Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
abstract: OBJECTIVE
  We aimed to assess the effects of psyllium supplementation on insulin sensitivity and other parameters of the metabolic syndrome in an at risk adolescent population.
  
  
  METHODS
  This study encompassed a participant-blinded, randomized, placebo-controlled, crossover trial. Subjects were 47 healthy adolescent males aged 15-16 years, recruited from secondary schools in lower socio-economic areas with high rates of obesity. Participants received 6 g/day of psyllium or placebo for 6 weeks, with a two-week washout before crossing over. Fasting lipid profiles, ambulatory blood pressure, auxological data, body composition, activity levels, and three-day food records were collected at baseline and after each 6-week intervention. Insulin sensitivity was measured by the Matsuda method using glucose and insulin values from an oral glucose tolerance test.
  
  
  RESULTS
  45 subjects completed the study, and compliance was very high: 87% of participants took >80% of prescribed capsules. At baseline, 44% of subjects were overweight or obese. 28% had decreased insulin sensitivity, but none had impaired glucose tolerance. Fibre supplementation led to a 4% reduction in android fat to gynoid fat ratio (p = 0.019), as well as a 0.12 mmol/l (6%) reduction in LDL cholesterol (p = 0.042). No associated adverse events were recorded.
  
  
  CONCLUSIONS
  Dietary supplementation with 6 g/day of psyllium over 6 weeks improves fat distribution and lipid profile (parameters of the metabolic syndrome) in an at risk population of adolescent males.
  
  
  BACKGROUND
  Australian New Zealand Clinical Trials Registry ACTRN12609000888268.
authors: Liggins Institute, University of Auckland, Auckland, New Zealand.
authors: Martin
authors: M
authors: de Bock
authors: José G B
authors: JG
authors: Derraik
authors: Christine M
authors: CM
authors: Brennan
authors: Janene B
authors: JB
authors: Biggs
authors: Greg C
authors: GC
authors: Smith
authors: David
authors: D
authors: Cameron-Smith
authors: Clare R
authors: CR
authors: Wall
authors: Wayne S
authors: WS
authors: Cutfield
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000293:Adolescent; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000494:pharmacology; D019587:Dietary Supplements; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism; D010919:Placebos; D011620:Psyllium / Q000008:administration & dosage / Q000494:pharmacology*; D012306:Risk; D016037:Single-Blind Method
chemical_list: D004043:Dietary Fiber; D010919:Placebos; D011620:Psyllium