title: Pathological crystallization of human immunoglobulins.
abstract: Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.
authors: Materials Processing Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. g09@mit.edu
authors: Ying
authors: Y
authors: Wang
authors: Aleksey
authors: A
authors: Lomakin
authors: Teru
authors: T
authors: Hideshima
authors: Jacob P
authors: JP
authors: Laubach
authors: Olutayo
authors: O
authors: Ogun
authors: Paul G
authors: PG
authors: Richardson
authors: Nikhil C
authors: NC
authors: Munshi
authors: Kenneth C
authors: KC
authors: Anderson
authors: George B
authors: GB
authors: Benedek
mesh_terms: D002021:Buffers; D003449:Cryoglobulinemia / Q000276:immunology* / Q000473:pathology*; D003450:Cryoglobulins / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012995:Solubility
chemical_list: D002021:Buffers; D003450:Cryoglobulins