title: The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.
abstract: Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.
authors: Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA. janey_wiggs@meei.harvard.edu
authors: Janey L
authors: JL
authors: Wiggs
authors: Michael A
authors: MA
authors: Hauser
authors: Wael
authors: W
authors: Abdrabou
authors: Robert Rand
authors: RR
authors: Allingham
authors: Donald L
authors: DL
authors: Budenz
authors: Elizabeth
authors: E
authors: Delbono
authors: David S
authors: DS
authors: Friedman
authors: Jae H
authors: JH
authors: Kang
authors: Douglas
authors: D
authors: Gaasterland
authors: Terry
authors: T
authors: Gaasterland
authors: Richard K
authors: RK
authors: Lee
authors: Paul R
authors: PR
authors: Lichter
authors: Stephanie
authors: S
authors: Loomis
authors: Yutao
authors: Y
authors: Liu
authors: Cathy
authors: C
authors: McCarty
authors: Felipe A
authors: FA
authors: Medeiros
authors: Sayoko E
authors: SE
authors: Moroi
authors: Lana M
authors: LM
authors: Olson
authors: Anthony
authors: A
authors: Realini
authors: Julia E
authors: JE
authors: Richards
authors: Frank W
authors: FW
authors: Rozsa
authors: Joel S
authors: JS
authors: Schuman
authors: Kuldev
authors: K
authors: Singh
authors: Joshua D
authors: JD
authors: Stein
authors: Douglas
authors: D
authors: Vollrath
authors: Robert N
authors: RN
authors: Weinreb
authors: Gadi
authors: G
authors: Wollstein
authors: Brian L
authors: BL
authors: Yaspan
authors: Sachiko
authors: S
authors: Yoneyama
authors: Don
authors: D
authors: Zack
authors: Kang
authors: K
authors: Zhang
authors: Margaret
authors: M
authors: Pericak-Vance
authors: Louis R
authors: LR
authors: Pasquale
authors: Jonathan L
authors: JL
authors: Haines
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003299:Cooperative Behavior; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D012107:Research Design; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents