title: Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
abstract: Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NFκB ligand-induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss.
authors: Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, Japan.
authors: Tsukasa
authors: T
authors: Tominari
authors: Michiko
authors: M
authors: Hirata
authors: Chiho
authors: C
authors: Matsumoto
authors: Masaki
authors: M
authors: Inada
authors: Chisato
authors: C
authors: Miyaura
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004195:Disease Models, Animal; D047309:Flavones / Q000494:pharmacology / Q000627:therapeutic use*; D008070:Lipopolysaccharides; D008336:Mandibular Diseases / Q000517:prevention & control; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D047309:Flavones; D008070:Lipopolysaccharides; C008661:nobiletin; C059006:tangeretin