title: Interest of exhaled biomarkers in occupational asthma to latex: a case report.
abstract: New methods for exploring pulmonary inflammation might be useful: measurements of exhaled nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) in exhaled breath condensate (EBC). The authors describe the application and utility of these methods in a case report of pediatric nurse presenting an occupational asthma to latex. Despite compliance with avoidance measures, respiratory discomfort had worsened during work. Classical tests (spirometry, monitoring of peak expiratory flow) were not contributing to objectify the discomfort. Exhaled NO and H(2)O(2) in EBC increased immediately after work periods, compared with rest periods. Application of these new methods, at the same time, in workplace appears useful in the objective demonstration of a temporal relation between work and respiratory problems. The results allowed the occupational physician to transfer the patient to a new work station more appropriate for her respiratory health status.
authors: Université Lille Nord de France, France. virginie.debroucker@chru-lille.fr
authors: V
authors: V
authors: de Broucker
authors: S
authors: S
authors: Hulo
authors: N
authors: N
authors: Cherot-Kornobis
authors: I
authors: I
authors: Lartigau-Sezary
authors: R
authors: R
authors: Matran
authors: A
authors: A
authors: Sobaszek
authors: J L
authors: JL
authors: Edme
mesh_terms: D000328:Adult; D059366:Asthma, Occupational / Q000139:chemically induced*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001944:Breath Tests; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D007840:Latex / Q000009:adverse effects*; D009569:Nitric Oxide / Q000032:analysis; D016273:Occupational Exposure
chemical_list: D015415:Biomarkers; D007840:Latex; D009569:Nitric Oxide; D006861:Hydrogen Peroxide