title: Chemical proteomics reveals heat shock protein 60 to be the main cellular target of the marine bioactive sesterterpene suvanine.
abstract: Marine bioactive compounds are potential drug leads because of their diverse pharmacological effects against human diseases. The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammatory activity, by application of a chemical proteomic approach. Heat Shock Protein 60, a chaperone involved in the inflammatory response, is the main cellular target of suvanine, which is also able to interfere with protein chaperone activity, giving evidence for its anti-inflammatory properties.
authors: Dipartimento di Scienze Farmaceutiche e BioMediche, Università degli Studi di Salerno, Via Ponte don Melillo, Fisciano, Salerno, Italy.
authors: Chiara
authors: C
authors: Cassiano
authors: Maria Chiara
authors: MC
authors: Monti
authors: Carmen
authors: C
authors: Festa
authors: Angela
authors: A
authors: Zampella
authors: Raffaele
authors: R
authors: Riccio
authors: Agostino
authors: A
authors: Casapullo
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018834:Chaperonin 60 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D011161:Porifera / Q000737:chemistry / Q000378:metabolism*; D040901:Proteomics; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D054830:Sesterterpenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D018834:Chaperonin 60; D011994:Recombinant Proteins; D054830:Sesterterpenes