title: Reconstitution of the central and peripheral nervous system during salamander tail regeneration.
abstract: We show that after tail amputation in Ambystoma mexicanum (Axolotl) the correct number and spacing of dorsal root ganglia are regenerated. By transplantation of spinal cord tissue and nonclonal neurospheres, we show that the central spinal cord represents a source of peripheral nervous system cells. Interestingly, melanophores migrate from preexisting precursors in the skin. Finally, we demonstrate that implantation of a clonally derived spinal cord neurosphere can result in reconstitution of all examined cell types in the regenerating central spinal cord, suggesting derivation of a cell with spinal cord stem cell properties.
authors: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden,  Germany.
authors: Levan
authors: L
authors: McHedlishvili
authors: Vladimir
authors: V
authors: Mazurov
authors: Kathrin S
authors: KS
authors: Grassme
authors: Kerstin
authors: K
authors: Goehler
authors: Bernhard
authors: B
authors: Robl
authors: Akira
authors: A
authors: Tazaki
authors: Kathleen
authors: K
authors: Roensch
authors: Annett
authors: A
authors: Duemmler
authors: Elly M
authors: EM
authors: Tanaka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D005727:Ganglia, Spinal / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D017933:Peripheral Nervous System / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology; D013234:Stem Cells / Q000166:cytology; D013623:Tail / Q000502:physiology*; D014562:Caudata
chemical_list: D018398:Homeodomain Proteins; C097899:homeobox protein HOXA9; D049452:Green Fluorescent Proteins