title: Maternal diets with low healthy eating index or Mediterranean diet adherence scores are associated with high cord-blood insulin levels and insulin resistance markers at birth.
abstract: OBJECTIVE
  Few studies have used healthy eating index (HEI) and mediterranean diet adherence (MDA) scores to evaluate the diet quality during pregnancy. To determine the relationship between first trimester diet quality and insulin sensitivity/resistance biomarkers at birth.
  
  
  METHODS
  Cord-blood insulin sensitivity/resistance biomarkers of the offspring of 35 women whose diets were 'adequate' or 'inadequate' according to their HEI score (>70 or ≤ 70, respectively) and their 13-point MDA score (≥ 7 or <7, respectively).
  
  
  RESULTS
  Low HEI-score diets contained less (g/1000 kcal) carbohydrates (CHO; P=0.027) and fibre (P=0.011), and more fats (P<0.001) and cholesterol (P<0.001), and contributed (percentage contribution to total energy (%En)) fewer CHO (P=0.005), more fats (P=<0.001) and saturated fatty acid (SFA; P=0.002) than their high HEI-score counterparts. Low MDA-score diets contained less (g/1000 kcal) fibre (P<0.001) and more cholesterol (P=0.05), had lower polyunsaturated fatty acids+monounsaturated fatty acid/SFA (PUFA+MUFA/SFA; P=0.05) and higher SFA/CHO (P=0.021) and ω-6/ω-3 PUFA ratios (P=0.044) than their respective counterparts. Women consuming the low HEI- or low MDA-score diets had low-fasting glycaemia (P=0.016 or P=0.025, respectively) but delivered infants with high insulinaemia (P=0.048 or P=0.017, respectively), homeostatic model assessment for insulin resistance (HOMA-IR; P=0.031 or P=0.049, respectively) and glycaemia (P=0.018 or P=0.048, respectively). The relative risk (RR) of high-neonatal glycaemia and insulinaemia were 7.6 (P=0.008) and 6.7 (P=0.017) for low vs high HEI-score groups. High HOMA-IR and high glucose RR were, respectively, 3.4 (P=0.043) and 3.9 (P=0.016) in neonates from the <7 MDA- vs ≥ 7 MDA-score group. These RRs were not affected by potential confounders.
  
  
  CONCLUSIONS
  Maternal diets with low HEI- or MDA-scores during the first trimester of pregnancy negatively affect insulin resistance markers at birth.
authors: Servicio de Análisis Clínicos, Hospital de Mérida, Badajoz, Spain.
authors: E
authors: E
authors: Gesteiro
authors: B
authors: B
authors: Rodríguez Bernal
authors: S
authors: S
authors: Bastida
authors: F J
authors: FJ
authors: Sánchez-Muniz
mesh_terms: D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism*; D015331:Cohort Studies; D004032:Diet; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D013030:Spain; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D007328:Insulin