title: Chagasic cardiomyopathy, from acute to chronic: is this mediated by host susceptibility factors?
abstract: Chronic chagasic cardiomyopathy (CCC) is the main contributor to morbidity and mortality among individuals chronically infected with the protozoan parasite Trypanosoma cruzi. However, cardiomyopathy develops in fewer than one-third of these patients. Among the different mechanisms to explain this variability are environmental factors, T. cruzi genetic diversity, and host susceptibility. CCC is the culmination of a pathologic process with an onset during the acute infection phase. Previous studies of host genetic factors have been limited to a few candidate genes. This review describes the pathologic features of acute and chronic myocarditis and the host susceptibility factors that may contribute to the development of chagasic cardiomyopathy.
authors: University of Colorado Denver, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA. andres.henaomartinez@ucdenver.edu
authors: Andrés F
authors: AF
authors: Henao-Martínez
authors: David A
authors: DA
authors: Schwartz
authors: Ivana V
authors: IV
authors: Yang
mesh_terms: D000208:Acute Disease; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002598:Chagas Cardiomyopathy / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D002908:Chronic Disease; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006183:H-2 Antigens / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007843:Latin America / Q000453:epidemiology; D008297:Male; D051379:Mice; D009205:Myocarditis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D000953:Antigens, Protozoan; D006183:H-2 Antigens