title: Retrieving oocytes from small non-stimulated follicles in polycystic ovary syndrome (PCOS): in vitro maturation (IVM) is not indicated in the new GnRH antagonist era.
abstract: It has been two decades since pregnancies have been obtained through in vitro maturation (IVM) of germinal vesicle-stage oocytes retrieved from non-stimulated ovaries. This technique first offered in PCOS cannot be recommended today in this indication because the results do not match those of regular ART, and new GnRH antagonist and agonist-trigger protocols reliably prevent OHSS.
authors: Department of Obstetrics, Gynecology and Reproductive Medicine, Université Paris Descartes, Paris Sorbonne Cité-Assistance Publique Hôpitaux de Paris, CHU Cochin, Paris, France. ddeziegler@orange.fr
authors: Dominique
authors: D
authors: de Ziegler
authors: Isabelle
authors: I
authors: Streuli
authors: Vanessa
authors: V
authors: Gayet
authors: Nelly
authors: N
authors: Frydman
authors: Osama
authors: O
authors: Bajouh
authors: Charles
authors: C
authors: Chapron
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000097:blood; D006727:Hormone Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods* / Q000639:trends; D007247:Infertility, Female / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology / Q000628:therapy*
chemical_list: D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone