title: Catalytic asymmetric carbon-carbon bond formation using alkenes as alkylmetal equivalents.
abstract: Catalytic asymmetric conjugate addition reactions with organometallic reagents are powerful reactions in synthetic chemistry. Procedures that use non-stabilized carbanions have been developed extensively, but these suffer from a number of limitations that prevent their use in many situations. Here, we report that alkylmetal species generated in situ from alkenes can be used in highly enantioselective 1,4-addition initiated by a copper catalyst. Using alkenes as starting materials is desirable because they are readily available and have favourable properties when compared to pre-made organometallics. High levels of enantioselectivity are observed at room temperature in a range of solvents, and the reaction tolerates functional groups that are not compatible with comparable methods-a necessary prerequisite for efficient and protecting-group-free strategies for synthesis.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford                 OX1 3TA, UK.
authors: Rebecca M
authors: RM
authors: Maksymowicz
authors: Philippe M C
authors: PM
authors: Roth
authors: Stephen P
authors: SP
authors: Fletcher