title: Assessing the impact of breeding strategies on inherited disorders and genetic diversity in dogs.
abstract: In the context of management of genetic diversity and control of genetic disorders within dog breeds, a method is proposed for assessing the impact of different breeding strategies that takes into account the genealogical information specific to a given breed. Two types of strategies were investigated: (1) eradication of an identified monogenic recessive disorder, taking into account three different mating limitations and various initial allele frequencies; and (2) control of the population sire effect by limiting the number of offspring per reproducer. The method was tested on four dog breeds: Braque Saint Germain, Berger des Pyrénées, Coton de Tulear and Epagneul Breton. Breeding policies, such as the removal of all carriers from the reproduction pool, may have a range of effects on genetic diversity, depending on the breed and the frequency of deleterious alleles. Limiting the number of offspring per reproducer may also have a positive impact on genetic diversity.
authors: AgroParisTech, UMR 1313, Génétique Animale et Biologie Intégrative, F-75231 Paris, France. gregoire.leroy@agroparistech.fr
authors: Grégoire
authors: G
authors: Leroy
authors: Xavier
authors: X
authors: Rognon
mesh_terms: D000818:Animals; D001947:Breeding / Q000379:methods*; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D005787:Gene Frequency; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D014644:Genetic Variation; D010375:Pedigree; D013045:Species Specificity