title: Comparison of single and split-dose flubendazole treatment for the nematode parasite Trichostrongylus tenuis in experimentally infected grey partridges Perdix perdix.
abstract: Different therapeutic regimes using flubendazole for the treatment of Trichostrongylus tenuis infection in experimentally infected grey partridges Perdix perdix were examined. Flubendazole dosages of 4, 8 and 20 mg/kg were administered orally as a single dose or split into 3 or 9 parts given over 9 days. The efficacy against adult worms in the caeca improved with dose rate. Split doses were at least as effective as single doses, which removed up to 83% of adult T. tenuis. A dose of 20 mg/kg administered on a daily basis over 3 or 9 days gave the best clearance of T. tenuis, resulting in a reduction of at least 95% in worm burden.
authors: Game & Wildlife Conservation Trust, Burgate Manor, Fordingbridge, Hants, UK.
authors: D
authors: D
authors: Purdy
authors: N J
authors: NJ
authors: Aebischer
authors: C
authors: C
authors: Davis
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001715:Bird Diseases / Q000188:drug therapy*; D046094:Galliformes; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary*; D014254:Trichostrongylus
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole; C018945:flubendazole