title: A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke.
abstract: Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 signaling using a unique tissue delivery system induces the formation of a new pattern of axonal projections in motor, premotor, and prefrontal circuits and mediates recovery after stroke in the mouse through these new projections. Combined blockade of ephrin-A5 and forced use of the affected limb promote new and surprisingly widespread axonal projections within the entire cortical hemisphere ipsilateral to the stroke. These data indicate that stroke activates a newly described membrane-bound astrocyte growth inhibitor to limit neuroplasticity, activity-dependent axonal sprouting, and recovery in the adult.
authors: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
authors: Justine J
authors: JJ
authors: Overman
authors: Andrew N
authors: AN
authors: Clarkson
authors: Ina B
authors: IB
authors: Wanner
authors: William T
authors: WT
authors: Overman
authors: Ilya
authors: I
authors: Eckstein
authors: Jaime L
authors: JL
authors: Maguire
authors: Ivo D
authors: ID
authors: Dinov
authors: Arthur W
authors: AW
authors: Toga
authors: S Thomas
authors: ST
authors: Carmichael
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D001522:Behavior, Animal; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D036386:Ephrin-A5 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D020127:Recovery of Function / Q000502:physiology*; D015398:Signal Transduction; D013194:Staining and Labeling; D020521:Stroke / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D036386:Ephrin-A5