title: [Contribution of platelet concentrates to oral and maxillo-facial surgery].
abstract: BACKGROUND
  We evaluated the clinical contribution of platelet concentrates to oral and maxillo-facial surgery.
  
  
  METHODS
  This bibliographic research was made using the PubMed MeSH database with the following keywords: "platelet rich fibrin" (PRF), "platelet rich plasma" (PRP), "bone", "facial bone", "dental implant", and "blood platelet". The research was made without any date or language limitation since English summaries were available. All summaries were read to evaluate the relevance of the article. Only original articles and case reports were considered. The articles were classified as "in vitro studies", "animal experiments", or "clinical studies". The research was stopped on March 22, 2012.
  
  
  RESULTS
  One hundred and sixty-nine articles were validated after excluding irrelevant articles, reviews, technical notes, and articles without English or French summaries. Seventeen were in vitro studies, 61 animal experiments, and 91 clinical studies. One hundred and ten complete articles were read to complete summary data. The data of in vitro studies univocally supports of using platelet concentrates. The data from animal experiment studies was less consensual and the validity of animal models was contested. The disparity of clinical study designs and the lack of rigorous methodology did not allow clearly determining platelet concentrate benefits for oral and maxillo-facial surgery.
  
  
  CONCLUSIONS
  PRF or PRP clinical benefit has not been clearly demonstrated yet. French regulations relative to their use should be clarified.
authors: Service de chirurgie plastique et maxillo-faciale, hôpital A.-Michallon, BP 217, 38043 Grenoble cedex, France. gbettega@chu-grenoble.fr
authors: G
authors: G
authors: Bettega
authors: E
authors: E
authors: Schir
mesh_terms: D032761:Animal Experimentation / Q000706:statistics & numerical data; D000818:Animals; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D006801:Humans; D019647:Oral Surgical Procedures / Q000379:methods* / Q000706:statistics & numerical data; D017713:Platelet Transfusion / Q000706:statistics & numerical data*; D053657:Platelet-Rich Plasma / Q000502:physiology*; D010983:Plateletpheresis / Q000706:statistics & numerical data; D039781:PubMed; D013515:Surgery, Oral / Q000379:methods* / Q000706:statistics & numerical data