title: Structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the Brazilian endemic tunicate Eudistoma vannamei.
abstract: The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC₅₀ values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.
authors: Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil.|Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil.
authors: Paula Christine
authors: PC
authors: Jimenez
authors: Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil.
authors: Diego Veras
authors: DV
authors: Wilke
authors: Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil.
authors: Elthon Gois
authors: EG
authors: Ferreira
authors: Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-903, Brazil.
authors: Renata
authors: R
authors: Takeara
authors: Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil.
authors: Manoel Odorico
authors: MO
authors: De Moraes
authors: Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE 60021-970, Brazil.
authors: Edilberto Rocha
authors: ER
authors: Silveira
authors: Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil.
authors: Tito Monteiro
authors: TM
authors: Da Cruz Lotufo
authors: Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-903, Brazil.
authors: Norberto Peporine
authors: 0000-0002-8159-3658
authors: NP
authors: Lopes
authors: Institute of Marine Sciences, LABOMAR, Federal University of Ceará, Fortaleza, CE 60165-081, Brazil.|Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil.
authors: Leticia Veras
authors: 0000-0003-1861-5153
authors: LV
authors: Costa-Lotufo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000737:chemistry; D001938:Brazil; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019311:Staurosporine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; C073929:7-oxostaurosporine; D019311:Staurosporine