title: Ozone gas effectively kills laboratory strains of Trichophyton rubrum and Trichophyton mentagrophytes using an in vitro test system.
abstract: BACKGROUND
  Ozone gas possesses antimicrobial potential against many microorganisms, however limited data exist on its effect on the keratinophilic dermatophyte fungi Trichophyton rubrum and Trichophyton mentagrophytes; two organisms commonly isolated as the etiological agent in onychomycosis and tinea pedis patients.
  
  
  OBJECTIVE
  We utilized a commercial ozone gas generation device for testing the fungicidal effects of ozone on ATCC strains of Trichophyton rubrum and Trichophyton mentagrophytes.
  
  
  RESULTS
  We demonstrated that ozone gas is effective in killing > 99% of viable fungi present in various experimental systems.
  
  
  CONCLUSIONS
  This work represents a proof of principle regarding ozone gas and its fungicidal effect on dermatophyte fungi. From these findings, further ozone gas studies will be conducted to develop a novel adjunct therapy for use in parallel with current antifungal medications and/or devices to better treat onychomycosis and tinea pedis patients in the short and long term.
authors: University of Toronto, Division of Dermatology, Department of Medicine.
authors: A K
authors: AK
authors: Gupta
authors: W
authors: W
authors: Brintnell
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D010126:Ozone / Q000494:pharmacology*; D012499:Sanitation; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D010126:Ozone