title: Does rapid eye movement sleep behavior disorder exist in psychiatric populations? A clinical and polysomnographic case-control study.
abstract: OBJECTIVE
  Rapid eye movement (REM) sleep behavior disorder (RBD) has been increasingly reported in patients with psychiatric disorders (pRBD). Although a close association with the usage of psychotropics has been postulated, it remains elusive whether psychotropics are the only causative factor of RBD symptoms in psychiatric populations. Moreover, there is limited literature documenting and quantifying the clinical and polysomnographic features in this population.
  
  
  METHODS
  A case-control study comparing the clinical and polysomnographic features of 31 pRBD patients with: (1) Age-, sex-, and psychiatric diagnoses-matched controls; and (2) Typical idiopathic RBD (tRBD) patients.
  
  
  RESULTS
  Despite being prescribed with similar psychotropics, pRBD patients had more dream-enacting behaviors (p<0.01), sleep-related injuries (p<0.01), and nightmares (p<0.01) than the psychiatric controls. pRBD patients were younger with more females, but they had comparable sleep-related injuries to tRBD. Both tRBD and pRBD had more REM-related muscle activity than controls (p<0.01) and the effect remained significant after adjusting for age, gender, and use of antidepressants.
  
  
  CONCLUSIONS
  Our study suggests that pRBD had comparable clinical features and consequences to those of tRBD. The occurrence of RBD symptoms in these patients may be related to a constellation of factors, including individual predisposition, depressive illness, antidepressants, and other clinical factors. Given the association of RBD and neurodegeneration in tRBD, further prospective follow-up of these patients is warranted.
authors: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region.
authors: Siu-Ping
authors: SP
authors: Lam
authors: Shirley Xin
authors: SX
authors: Li
authors: Joey Wy
authors: JW
authors: Chan
authors: Vincent
authors: V
authors: Mok
authors: Joshua
authors: J
authors: Tsoh
authors: Anne
authors: A
authors: Chan
authors: Mandy Wai-Man
authors: MW
authors: Yu
authors: Christine Yk
authors: CY
authors: Lau
authors: Jihui
authors: J
authors: Zhang
authors: Venny
authors: V
authors: Lam
authors: Crover Kw
authors: CK
authors: Ho
authors: Yun-Kwok
authors: YK
authors: Wing
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000150:complications*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D020187:REM Sleep Behavior Disorder / Q000150:complications* / Q000175:diagnosis*; D012895:Sleep, REM / Q000502:physiology
chemical_list: D000928:Antidepressive Agents