title: Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures.
abstract: A rapid and efficient protocol to afford the title compound 2-[(18)F]-fluoro-2,2-difluoroethyl tosylate ([(18)F]7b) is described. Starting from [(18)F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([(18)F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
authors: The Wolfson Brain Imaging Centre, Box 65 Addenbrooke's Hospital, CB2 0QQ, Cambridge, United Kingdom. pr340@wbic.cam.ac.uk
authors: Patrick J
authors: PJ
authors: Riss
authors: Valentina
authors: V
authors: Ferrari
authors: Laurent
authors: L
authors: Brichard
authors: Paul
authors: P
authors: Burke
authors: Robert
authors: R
authors: Smith
authors: Franklin I
authors: FI
authors: Aigbirhio
mesh_terms: D005462:Fluorine Radioisotopes; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D011854:Radiochemistry; D014105:Tosyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D014105:Tosyl Compounds