title: Current trends in the chemotherapy of colorectal cancer.
abstract: The increase in the therapeutic arsenal in the last 20 years, has given rise to changes in treating colorectal cancer (CRC) with only pyrimidines to combine several cytotoxic drugs. However, the present question is to determine the optimal sequence of this combination. This review presents an update of data on chemical and clinical features of chemotherapy used for colorectal cancer and the mechanisms of cellular resistance and potential predictive and prognostic biomarkers, which may contribute to a better selection of a therapeutic strategy.
authors: Department of Clinical Oncology, General University Hospital of Ciudad Real (HGUCR), Ciudad Real, Spain. migueberci@gmail.com
authors: M A
authors: MA
authors: Berciano-Guerrero
authors: J C
authors: JC
authors: Villa-Guzmán
authors: R
authors: R
authors: Acosta-Guerrero
authors: G
authors: G
authors: Castañeda-Peñalvo
authors: J
authors: J
authors: Rodríguez-Flores
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004358:Drug Therapy / Q000639:trends; D006801:Humans; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents