title: Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome.
abstract: BACKGROUND
  This study aimed to assess whether heart fatty acid-binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) could be used for the accurate diagnosis of acute myocardial infarction (AMI) in acute coronary syndrome (ACS) patients.
  
  
  METHODS
  The study included 108 ACS patients admitted to a coronary unit within 3 h after chest pain onset. AMI was distinguished from unstable angina (UA) using a classical cardiac troponin I (cTnI) assay. H-FABP and GPBB were measured by ELISA on admission (0 h) and at 3, 6, 12, and 24 h after admission; their accuracy to diagnose AMI was assessed using statistical methods.
  
  
  RESULTS
  From 92 patients with ACS; 71 had AMI. H-FABP and GPBB had higher peak value after 3 h from admission than cTnI (P = 0.001). Both markers normalized at 24 h. The area under the receiver operating characteristic curves was significantly greater for both markers in AMI patients than in UA patients at all time points tested, including admission (P < 0.001). At admission, the H-FABP (37%) and GPBB (40%) sensitivities were relatively low. They increased at 3 and 6 h after admission for both markers and decreased again after 24 h. It was 40% for H-FABP and approximately 2-times lower for GPBB (P < 0.01). In AMI patients, both biomarkers had similar specificities, positive- and negative-predictive values, positive and negative likelihood ratios, and risk ratios for AIM.
  
  
  CONCLUSIONS
  H-FABP and GPBB can contribute to early AMI diagnosis and can distinguish AMI from UA.
authors: Department of Cardiovascular Medicine, University Hospital Rijeka, Rijeka, Croatia.
authors: Zlatko
authors: Z
authors: Cubranic
authors: Zeljko
authors: Z
authors: Madzar
authors: Sanja
authors: S
authors: Matijevic
authors: Stefica
authors: S
authors: Dvornik
authors: Elizabeta
authors: E
authors: Fisic
authors: Vjekoslav
authors: V
authors: Tomulic
authors: Juraj
authors: J
authors: Kunisek
authors: Gordana
authors: G
authors: Laskarin
authors: Igor
authors: I
authors: Kardum
authors: Luka
authors: L
authors: Zaputovic
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003951:Diagnostic Errors / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D025002:Glycogen Phosphorylase, Brain Form / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012307:Risk Factors; D013997:Time Factors
chemical_list: C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D025002:Glycogen Phosphorylase, Brain Form