title: Ferriman-Gallwey scores, serum androgen and mullerian inhibiting substance levels in hirstute adolescent girls.
abstract: OBJECTIVE
  To study Ferriman-Gallwey (FG) scoring in adolescents with an aim to correlate these scores with serum androgens and mullerian inhibiting substance (MIS).
  
  
  METHODS
  Cross sectional study.
  
  
  METHODS
  Pediatric and Adolescent Gynecology Clinic of a university hospital.
  
  
  METHODS
  Twenty-four hirsute adolescent girls age 12-19 with a FG score of 6 or greater.
  
  
  METHODS
  FG examination and collection of serum levels of MIS, total testosterone, free testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, cortisol, and androstenedione.
  
  
  METHODS
  Correlation between FG scores in adolescents and serum androgens and MIS.
  
  
  RESULTS
  Weak correlations were seen between FG score and FSH, free-testosterone, total testosterone, and cortisol. Increasing FG scores correlated with an increase in cortisol. As FG score increased, FSH, free-testosterone, and total testosterone decreased. There was no statistical relationship between FG score and LH, androstenedione, prolactin, and MIS. There were weak positive correlations between MIS levels and FSH, total testosterone, and androstenedione. There was no evidence for a linear relationship between MIS levels and LH, free testosterone, cortisol, prolactin, and FG score.
  
  
  CONCLUSIONS
  The utility of FG scoring in adolescents is unknown. There were no direct correlations found with MIS levels and FG score. MIS was not found to be a predictor of hirsutism. A larger study is needed to assess the clinical relevance of FG scoring and presence of underlying causes of hirsutism in adolescents.
authors: University of Louisville, Department of Pediatric and Adolescent Gynecology, Louisville, KY, USA.
authors: S P
authors: SP
authors: Hertweck
authors: J L
authors: JL
authors: Yoost
authors: M E
authors: ME
authors: McClure
authors: Y
authors: Y
authors: Siow
authors: G N
authors: GN
authors: Brock
authors: K A
authors: KA
authors: Wintergerst
authors: M E
authors: ME
authors: Fallat
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000728:Androgens; D054304:Anti-Mullerian Hormone