title: A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors.
abstract: OBJECTIVE
  To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy.
  
  
  METHODS
  A total of 40 cases of SLCTs were retrospectively reviewed.
  
  
  RESULTS
  The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary. Four tumors were well differentiated, 14 were intermediately differentiated, 20 were poorly differentiated, and 2 were undefined; 2 cases had heterologous elements, and 3 had a retiform pattern. The patients were classified into 3 groups: androgen excess (25/40), estrogen excess (6/40), and no endocrine changes (9/40). The percentages of tumors >10 cm in diameter were 8.0%, 16.7% and 40.0%, respectively; the percentages of poor differentiation were 40.0%, 50.0% and 77.8%, respectively; and the percentages of tumor rupture were 20.0%, 16.7% and 66.7%, respectively. One patient underwent cystectomy, 27 underwent unilateral salpingo-oophorectomy, and 12 underwent total hysterectomy and bilateral salpingo-oophorectomy. A total of 23 patients received postoperative chemotherapy. One patient died of diabetic nephropathy, and 3 were lost to follow up. The remaining 36 were followed up from 12 to 377 (average 70.4) months. Two patients with stage Ic tumors of poor differentiation had a recurrence within 13 and 21 months, and both obtained complete remission after the second surgery and chemotherapy.
  
  
  CONCLUSIONS
  The prognosis of SLCTs is good, although poorly differentiated tumors may recur. Conservative surgery is acceptable for young patients wishing to preserve fertility, and postoperative adjuvant chemotherapy and long-term follow up are recommended to those with high-risk factors.
authors: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors: Ting
authors: T
authors: Gui
authors: Dongyan
authors: D
authors: Cao
authors: Keng
authors: K
authors: Shen
authors: Jiaxin
authors: J
authors: Yang
authors: Yiwen
authors: Y
authors: Zhang
authors: Qi
authors: Q
authors: Yu
authors: Xirun
authors: X
authors: Wan
authors: Yang
authors: Y
authors: Xiang
authors: Yu
authors: Y
authors: Xiao
authors: Lina
authors: L
authors: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D010052:Ovariectomy; D011379:Prognosis; D012189:Retrospective Studies; D058994:Salpingectomy; D018310:Sertoli-Leydig Cell Tumor / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D055815:Young Adult