title: Cognitive assessment protocol design in the ISSYS (Investigating Silent Strokes in hYpertensives: a magnetic resonance imaging Study).
abstract: Hypertension and silent cerebrovascular lesions (SCL) detected by brain magnetic resonance imaging (MRI) are associated with an increased risk of cognitive decline. In a prospective observational study in 1000 hypertensive patients, aged 50-70 years, with no prior history of stroke or dementia, we will study the presence of mild cognitive impairment (MCI) and the relationship between SCL and cognition. All participants will be assessed by means of the Dementia Rating Scale-2 (DRS-2) and will undergo a brain MRI. In order to better characterize MCI and future dementia risk in our cohort, those patients that are suspected to be cognitively impaired according to the DRS-2 results will have a further neurological evaluation and complete neuropsychological testing. Follow-up for the entire cohort is planned to last for at least 3 years.
authors: Neurovascular Research Laboratory, Vall Hebron's Research Institute, Neurovascular Section, Vall Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain.
authors: I
authors: I
authors: Riba
authors: C I
authors: CI
authors: Jarca
authors: X
authors: X
authors: Mundet
authors: J L
authors: JL
authors: Tovar
authors: F
authors: F
authors: Orfila
authors: C
authors: C
authors: Nafría
authors: A
authors: A
authors: Raga
authors: A
authors: A
authors: Girona
authors: P
authors: P
authors: Fernández-Lara
authors: X
authors: X
authors: Castañé
authors: J
authors: J
authors: Alvarez Sabin
authors: I
authors: I
authors: Fernández Cortiñas
authors: O
authors: O
authors: Maisterra
authors: J
authors: J
authors: Montaner
authors: P
authors: P
authors: Delgado
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales