title: Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations.
abstract: Mutual clinical and molecular interactions between iron and glucose metabolism have been reported. We aimed to investigate a potential effect of glucose on iron homeostasis. We found that serum iron concentrations gradually decreased over 180 min after the administration of 75 g of glucose from 109.8 ± 45.4 mg/L to 94.4 ± 40.4 mg/L (P<.001; N=40) but remained unchanged in control subjects receiving tap water (N=21). Serum hepcidin, the key iron regulatory hormone which is mainly derived from hepatocytes but also expressed in pancreatic β-cells, increased within 120 min after glucose ingestion from 19.7 ± 9.9 nmol/L to 31.4 ± 21.0 nmol/L (P<.001). In cell culture, glucose induced the secretion of hepcidin and insulin into the supernatant of INS-1E cultures, but did not change the amount of hepcidin detectable in the hepatocyte cell culture HepG2. We additionally confirmed the expression of hepcidin in a human islet cell preparation. These results suggest that glucose acts as a regulator of serum iron concentrations, most likely by triggering the release of hepcidin from β-cells.
authors: Department of Laboratory Medicine, Paracelsus Medical University Salzburg, Austria. e.aigner@salk.at
authors: Elmar
authors: E
authors: Aigner
authors: Thomas K
authors: TK
authors: Felder
authors: Hannes
authors: H
authors: Oberkofler
authors: Penelope
authors: P
authors: Hahne
authors: Simon
authors: S
authors: Auer
authors: Selma
authors: S
authors: Soyal
authors: Andreas
authors: A
authors: Stadlmayr
authors: Karin
authors: K
authors: Schwenoha
authors: Christian
authors: C
authors: Pirich
authors: Paul
authors: P
authors: Hengster
authors: Christian
authors: C
authors: Datz
authors: Wolfgang
authors: W
authors: Patsch
mesh_terms: D000328:Adult; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005951:Glucose Tolerance Test; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D064451:Hepcidins; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D007340:Insulinoma / Q000188:drug therapy / Q000378:metabolism; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051381:Rats
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; C578703:Hamp protein, rat; D064451:Hepcidins; D007501:Iron; D005947:Glucose