title: [Preconditioning impact on coronary perfusion during ischemia and reperfusion of heart].
abstract: Recent studies have confirmed that ischemic preconditioning prevents appearance of reperfusion endothelial dysfunction. However, the issue of preconditioning impact on no-reflow phenomenon remains unresolved. The receptor mechanisms involved in the cardioprotective and vasoprotective effects of preconditioning are different. The ability of preconditioning in preventing reperfusion endothelial dysfunction is dependent upon bradykinin B2-receptor activation and not dependent upon adenosine receptor stimulation. The vasoprotective effect of preconditioning is mediated via mechanisms relying in part on activation of protein kinase C, NO-synthase, cyclooxygenase, mitochondrial K(ATP)-channel opening and an enhancement of antioxidative protection of the heart. The delayed preconditioning also exerts endothelium-protective effect. Peroxynitrite, NO* and O2* are the triggers of this effect but a possible end-effector involves endothelial NO-synthase.
authors: L N
authors: LN
authors: Maslov
authors: Iu B
authors: IuB
authors: Lishmanov
authors: P
authors: P
authors: Oeltgen
authors: J-M
authors: JM
authors: Peĭ
authors: A V
authors: AV
authors: Krylatov
authors: E I
authors: EI
authors: Barzakh
authors: A G
authors: AG
authors: Portnichenko
authors: R
authors: R
authors: Meshoulam
mesh_terms: D001920:Bradykinin / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D004789:Enzyme Activation; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D043782:Receptor, Bradykinin B2 / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism
chemical_list: D005609:Free Radicals; D015221:Potassium Channels; D043782:Receptor, Bradykinin B2; D018047:Receptors, Purinergic P1; D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D011451:Prostaglandin-Endoperoxide Synthases; D011493:Protein Kinase C; D001920:Bradykinin