title: Phylogeny and evolution of Hytrosaviridae.
abstract: The Hytrosaviridae comprises a family of dsDNA viruses with a circular genome of 120-190 kb p. They are exclusively associated with Diptera, such as the tsetse fly, the house fly and the Narcissus bulb fly. Hytrosaviruses cause a very unique pathology including hypertrophy of salivary glands as well as testicular and ovarian malformation. On the other hand these viruses share a significant number of gene homologues with other dsDNA viruses, esp. baculoviruses and nudiviruses. These gene homologues include twelve so-called baculovirus core genes involved in transcription, DNA replication and the infection process. Most strikingly, the Musca domestica salivary gland hypertrophy virus (MdSGHV) encodes a homologue of a polyhedrin/granulin gene of Alpha-, Beta-, Gammabaculoviruses. Hence, it is proposed that hytrosaviruses are phylogenetically related to baculoviruses but evolved in a very close association with their dipteran hosts.
authors: Institute for Biological Control, Julius Kühn-Institut, Federal Research Centre for Cultivated Plants, Heinrichstr. 243, 64287 Darmstadt, Germany. Johannes.Jehle@jki.bund.de
authors: Johannes A
authors: JA
authors: Jehle
authors: Adly M M
authors: AM
authors: Abd-Alla
authors: Yongjie
authors: Y
authors: Wang
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004267:DNA Viruses / Q000235:genetics*; D019143:Evolution, Molecular; D016679:Genome, Viral / Q000235:genetics*; D007304:Insect Viruses / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny