title: Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancy.
abstract: BACKGROUND
  This study was designed to evaluate maternal levels of leptin and interferon-gamma (IFN-gamma) in pregnancy complicated with hypertension and to assess the role of cytokines in predicting the risk of cesarean section.
  
  
  METHODS
  This was a cohort study with a prospective follow-up. After proportional sampling procedure, the study included the follow-up of 40 women with hypertensive disorders of pregnancy (pregnancy-induced hypertension [PIH] or preeclampsia [PE]) and 40 uncomplicated pregnancies. Women were followed from the time of admission to the delivery. Levels of leptin and interferon-gamma were measured in serum samples from all women. A p-value <0.05 was considered as significant.
  
  
  RESULTS
  Significant increase in IFN-gamma and leptin concentration in women with pre-eclampsia was observed. We found a significant 1.4-fold increase in the risk of birth by cesarean section associated with the increase of the IFN-gamma concentration by 0.1 pg/ml and almost 3-fold increase in the risk associated with the increase of the leptin concentration.
  
  
  CONCLUSIONS
  IFN-γ and leptin might be risk markers of cesarean section in hypertension disorders of pregnancy, but further studies supporting this evidence are needed.
authors: Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Cracow, Poland. morytlew@cyf-kr.edu.pl
authors: Krzysztof
authors: K
authors: Rytlewski
authors: Hubert
authors: H
authors: Huras
authors: Katarzyna
authors: K
authors: Kuśmierska-Urban
authors: Aleksander
authors: A
authors: Gałaś
authors: Alfred
authors: A
authors: Reroń
mesh_terms: D000328:Adult; D001034:Apgar Score; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood*; D007743:Labor, Obstetric / Q000097:blood; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D011247:Pregnancy
chemical_list: D020738:Leptin; D007371:Interferon-gamma