title: Brain event-related potentials associated with psychiatric symptoms in amphetamine-type stimulant dependent patients.
abstract: OBJECTIVE
  To explore the correlation between brain event-related potentials (ERPs) and psychiatric symptoms in patients with amphetamine-type stimulants (ATS) dependence.
  
  
  METHODS
  Using Galileo Sirius 32-channels digital-evoked potential system, we measured the auditory P300 ERP in 40 ATS dependence subjects and 30 normal controls, respectively. Symptom Checklist 90 (SCL-90) was used to rate the psychiatric symptoms in the subjects.
  
  
  RESULTS
  In ATS dependence subjects, the latency of N2, latency of P3, and inter-peak latency of P2-N2 were significantly longer than those in controls, respectively (P < 0.05). The amplitude of P300 in ATS dependence subjects was significantly lower than that in controls (P < 0.01). Besides, significantly lower amplitude of P3 and longer latency of P3 were found in ATS dependence subjects suffering from psychiatric symptoms than those without psychotic symptoms (P < 0.05). Furthermore, in ATS dependence subjects, the latency of N2 was negatively correlated with the scores of anxiety factor (r = -0.366) and paranoid ideation factor of SCL-90; the latency of P3 negatively correlated with the scores of psychoticism (r = -0.430) and somatization (r = -0.397) factor; also, the amplitude of P3 was negatively correlated with the score ofpsychoticism factor (r = -0.486).
  
  
  CONCLUSIONS
  These findings suggest cognitive dysfunction may be one of results of ATS dependence.
authors: Affiliated Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, China
authors: Yao
authors: Y
authors: Zhang
authors: Bao-Liang
authors: BL
authors: Zhong
authors: Yi
authors: Y
authors: Li
authors: Zi-Long
authors: ZL
authors: Ma
authors: Yan
authors: Y
authors: Tian
authors: Jun
authors: J
authors: Tang
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000503:physiopathology*; D000662:Amphetamines; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D000662:Amphetamines