title: Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy.
abstract: BACKGROUND
  The current study aimed to assess the role of salvage surgery for failure cases of oropharyngeal cancer (OPC) undergoing initial chemoradiotherapy (CRT).
  
  
  METHODS
  The data for 523 patients with previously untreated OPC were gathered from 12 institutions belonging to the Head and Neck Cancer Study Group in Japan Clinical Oncology Group (JCOG).
  
  
  RESULTS
  Of the 170 patients who received CRT, 35 patients (21%) had local recurrence or residual disease. Only 11 patients underwent further salvage surgery, and 24 patients received nonsurgical treatment. There were statistically significant differences between the two groups in terms of patient age and the presence of a simultaneous regional recurrence. The 5-year overall survival rates for the patients who underwent salvage surgery were 49.1%, whereas those for the patients who received nonsurgical treatment were 16.3%.
  
  
  CONCLUSIONS
  The initial treatment method for OPC should be decided carefully and the limitations of salvage surgery should be fully considered.
authors: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
authors: Satoshi
authors: S
authors: Kano
authors: Akihiro
authors: A
authors: Homma
authors: Ryuichi
authors: R
authors: Hayashi
authors: Kazuyoshi
authors: K
authors: Kawabata
authors: Kunitoshi
authors: K
authors: Yoshino
authors: Shigemichi
authors: S
authors: Iwae
authors: Yasuhisa
authors: Y
authors: Hasegawa
authors: Kenichi
authors: K
authors: Nibu
authors: Takakuni
authors: T
authors: Kato
authors: Kiyoto
authors: K
authors: Shiga
authors: Kazuto
authors: K
authors: Matsuura
authors: Nobuya
authors: N
authors: Monden
authors: Masato
authors: M
authors: Fujii
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D018365:Neoplasm, Residual / Q000473:pathology / Q000628:therapy; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D016879:Salvage Therapy; D015996:Survival Rate; D016896:Treatment Outcome