title: [Influence of corticotropin-releasing factor fragment CRF4-6 on metabolism in rats].
abstract: Influence of corticotropin-releasing factor fragment CRF4-6 on metabolism in the rat was investigated in this study. Tripeptide (10 mkg/rat) after intracerebroventricular infusion to anesthetized animals increased metabolic rate, not affecting the respiratory ratio, induced hyperglycemia and hyperthermia. Synchronously with that heart rate and arterial pressure did also increase. Changes in energy metabolism induced by CRF4-6 closely resemble the effect of untruncated corticotropin-releasing factor molecule. Results of this study and the range of tripeptide effects described previously evidence that CRF4-6 is a physiologically active regulatory molecule, a derivative of corticotropin-releasing factor, that expands and prolongs effects of the parent molecule.
authors: A A
authors: AA
authors: Andreev-Andrievskiĭ
authors: L A
authors: LA
authors: Andreeva
authors: A A
authors: AA
authors: Mart'ianov
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage*; D005334:Fever / Q000139:chemically induced / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism; D012119:Respiration / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D009842:Oligopeptides; D018019:Receptors, Corticotropin-Releasing Hormone; D002245:Carbon Dioxide; D003346:Corticotropin-Releasing Hormone