title: Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex.
abstract: The Ccr4-Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease-exonuclease-phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins.
authors: School of Pharmacy, University of Nottingham, University Park, Nottingham, UK.
authors: Rachel
authors: R
authors: Doidge
authors: Saloni
authors: S
authors: Mittal
authors: Akhmed
authors: A
authors: Aslam
authors: G Sebastiaan
authors: GS
authors: Winkler
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000235:genetics*; D006801:Humans; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics*; D054398:Receptors, CCR4; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D054398:Receptors, CCR4; D012260:Ribonucleases