title: Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien.
abstract: Novel simplified side chains of the potent RNA polymerase inhibitor etnangien were designed, synthesized and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.
authors: Organische Chemie, Ruprecht-Karls-Universität Heidelberg, INF 270, D-69120 Heidelberg, Germany.
authors: Mario
authors: M
authors: Altendorfer
authors: Herbert
authors: H
authors: Irschik
authors: Dirk
authors: D
authors: Menche
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000201:enzymology; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011090:Polyenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D011090:Polyenes; C521655:etnangien; D012321:DNA-Directed RNA Polymerases