title: Endocytosis and control of Notch signaling.
abstract: The Notch signaling pathway controls patterning and cell fate decisions during development in metazoans, and is associated with human diseases such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and certain cancers. Studies over the last several years have revealed sophisticated regulation of both the membrane-bound Notch receptor and its ligands by vesicle trafficking. This is perhaps most evident in neural progenitor cells in Drosophila, which divide asymmetrically to segregate Numb, an endocytic adaptor protein that acts as a Notch pathway inhibitor, to one daughter cell. Here, we discuss recent findings addressing how receptor and ligand trafficking to specific membrane compartments control activation of the Notch pathway in asymmetrically dividing cells and other tissues.
authors: Program in Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA 19111, United States.
authors: Vasundhara
authors: V
authors: Kandachar
authors: Fabrice
authors: F
authors: Roegiers
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D007605:Juvenile Hormones / Q000378:metabolism; D008024:Ligands; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D021381:Protein Transport; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008024:Ligands; D051880:Receptors, Notch; C060606:numb protein, Drosophila