title: Community acquired Klebsiella pneumoniae, K1 serotype.  Invasive liver abscess with bacteremia and endophthalmitis.
abstract: A community-acquired syndrome of cryptogenic invasive Klebsiella pneumoniae (K. pneumoniae) liver abscess (CIKPLA) has been emerging worldwide over the past 3 decades, particularly in Taiwan and Korea. It is caused by highly virulent hypermucoviscous, rmpA positive K. pneumoniae serotype K1. This condition occurs in predominantly diabetic persons with no underlying hepatobiliary disease. Metastatic infections of the brain, meninges, lungs, pleura, bones, soft tissues, and eyes are unique features of this syndrome. We report a laboratory-confirmed regulator of mucoid phenotype (rmp)A-positive, K1 serotype K. pneumoniae from Saudi Arabia in 2 diabetic native Saudis presenting with community acquired, invasive liver abscess complicated in one by endogenous endophthalmitis. Following medical and surgical treatment, both patients were cured from liver abscesses, however there was unilateral permanent visual loss in one patient.
authors: Infectious Diseases Division, Department of Medicine, King Fahad Medical City, PO Box 59046, Riyadh 11525, Kingdom of Saudi Arabia. mushirae@yahoo.com
authors: Mushira A
authors: MA
authors: Enani
authors: Noura A
authors: NA
authors: El-Khizzi
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D017714:Community-Acquired Infections; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications* / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D008100:Liver Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents