title: Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia.
abstract: Studies focused on elderly acute promyelocytic leukemia (APL) are relatively limited. To evaluate prognostic impact in elderly APL, we compared the long-term outcome of elderly APL patients (60-70 years) with younger patients (15-59 years) treated with all-trans retinoic acid combined with anthracycline and cytarabine in the Japan Adult Leukemia Study Group (JALSG) APL97 study. Of 283 evaluable patients, 46 (16.3%) were elderly who had more frequent lower platelet (P = 0.04), lower albumin (P = 0.006) and performance status 3 (P = 0.02), higher induction death rate due to differentiation syndrome (P = 0.03), and non-relapse mortality (NRM) during consolidation therapy (P = 0.001). Overall survival was significantly inferior in elderly patients (P = 0.005), but disease-free survival and cumulative incidence of relapse were not. Better therapeutic approaches should be considered to reduce NRM during induction and consolidation therapy in elderly APL. This study was registered at http://www.umin.ac.jp/ctrj/ under C000000206.
authors: Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors: Takaaki
authors: T
authors: Ono
authors: Akihiro
authors: A
authors: Takeshita
authors: Yuji
authors: Y
authors: Kishimoto
authors: Hitoshi
authors: H
authors: Kiyoi
authors: Masaya
authors: M
authors: Okada
authors: Takahiro
authors: T
authors: Yamauchi
authors: Motohiro
authors: M
authors: Tsuzuki
authors: Kentaro
authors: K
authors: Horikawa
authors: Mitsuhiro
authors: M
authors: Matsuda
authors: Katsuji
authors: K
authors: Shinagawa
authors: Fumihiko
authors: F
authors: Monma
authors: Shigeki
authors: S
authors: Ohtake
authors: Chiaki
authors: C
authors: Nakaseko
authors: Masatomo
authors: M
authors: Takahashi
authors: Yukihiko
authors: Y
authors: Kimura
authors: Masako
authors: M
authors: Iwanaga
authors: Norio
authors: N
authors: Asou
authors: Tomoki
authors: T
authors: Naoe
mesh_terms: D000328:Adult; D000368:Aged; D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage
chemical_list: D018943:Anthracyclines; D003561:Cytarabine; D014212:Tretinoin