title: Perivascular stem cell niche in head and neck cancer.
abstract: Cancers may contain a small sub-population of uniquely tumorigenic cells that exhibit self-renewal and multipotency, i.e. cancer stem cells (CSCs). These cells reside in invasive fronts in close proximity to blood vessels in many tumors, including head and neck squamous cell carcinomas (HNSCCs). Recent evidence suggests that CSC resist chemotherapy and "drive" local recurrence and metastatic spread. Notably, endothelial cell-initiated signaling is critical for the survival and self-renewal of CSC and may play a role in resistance to therapy. Therefore, patients with head and neck cancer might benefit from therapies that target the CSC directly or their supportive perivascular niche.
authors: Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, School of Dentistry, United States.
authors: Kathryn E
authors: KE
authors: Ritchie
authors: Jacques E
authors: JE
authors: Nör
mesh_terms: D000071916:AC133 Antigen; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D010455:Peptides / Q000378:metabolism; D055153:Stem Cell Niche
chemical_list: D000071916:AC133 Antigen; D020533:Angiogenesis Inhibitors; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D010455:Peptides