title: Synthesis and biological activity of 23-hydroxybetulinic acid C-28 ester derivatives as antitumor agent candidates.
abstract: 23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC(50 values of 8.35 µM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.
authors: School of Pharmacy, Yantai University, Yantai 264005, Shandong, China.
authors: Yi
authors: Y
authors: Bi
authors: Jinyi
authors: J
authors: Xu
authors: Fei
authors: F
authors: Sun
authors: Xiaoming
authors: X
authors: Wu
authors: Wencai
authors: W
authors: Ye
authors: Yijun
authors: Y
authors: Sun
authors: Wenwen
authors: W
authors: Huang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004952:Esters; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008813:Mice, Inbred ICR; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: C468651:23-hydroxybetulinic acid; D000970:Antineoplastic Agents; D004952:Esters; D014315:Triterpenes; D003520:Cyclophosphamide; D005472:Fluorouracil