title: Assessment of modified gold surfaced titanium implants on skeletal fixation.
abstract: Noncemented implants are the primary choice for younger patients undergoing total hip replacements. However, the major concern in this group of patients regarding revision is the concern from wear particles, periimplant inflammation, and subsequently aseptic implant loosening. Macrophages have been shown to liberate gold ions through the process termed dissolucytosis. Furthermore, gold ions are known to act in an anti-inflammatory manner by inhibiting cellular NF-κB-DNA binding. The present study investigated whether partial coating of titanium implants could augment early osseointegration and increase mechanical fixation. Cylindrical porous coated Ti-6Al-4V implants partially coated with metallic gold were inserted in the proximal region of the humerus in ten canines and control implants without gold were inserted in contralateral humerus. Observation time was 4 weeks. Biomechanical push out tests and stereological histomorphometrical analyses showed no statistically significant differences in the two groups. The unchanged parameters are considered an improvement of the coating properties, as a previous complete gold-coated implant showed inferior mechanical fixation and reduced osseointegration compared to control titanium implants in a similar model. Since sufficient early mechanical fixation is achieved with this new coating, it is reasonable to investigate the implant further in long-term studies.
authors: Department of Orthopaedics, Orthopaedic Research Center, Aarhus University Hospital, Aarhus C, Denmark. kasrazainali@gmail.com
authors: Kasra
authors: K
authors: Zainali
authors: Gorm
authors: G
authors: Danscher
authors: Thomas
authors: T
authors: Jakobsen
authors: Jorgen
authors: J
authors: Baas
authors: Per
authors: P
authors: Møller
authors: Joan E
authors: JE
authors: Bechtold
authors: Kjeld
authors: K
authors: Soballe
mesh_terms: D000497:Alloys; D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects; D004285:Dogs; D005260:Female; D005592:Fracture Fixation; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D006811:Humerus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D014025:Titanium / Q000494:pharmacology*
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D006046:Gold; D014025:Titanium