title: Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression.
abstract: The immunotolerant human leukocyte antigen (HLA)-G has direct inhibitory effects on natural killer cells, dendritic cells, T cells and can indirectly induce tolerant regulatory cells. The significance of the aberrant HLA-G expression in malignant contexts has been intensively investigated. In the current study, HLA-G expression in 22 normal cervical tissues, 14 cervical intraepithelial neoplasia (CIN) patients and 129 patients with squamous cell cervical cancer were examined using immunohistochemistry. The association of HLA-G expression with disease progression was calculated with the Pearson Chi-square test. It was found that HLA-G expression was absent in normal cervical tissues, and that HLA-G expression was increased from patients with CIN III (35.7%, 4/14) to patients with cervical cancer (62.8%, 81/129). Among the cervical cancer patients, HLA-G expression in FIGO stage I, II, and stage III+IV was 53.6% (45/84), 76.3% (29/38), and 100.0% (7/7), respectively. Taken together, our findings indicated that HLA-G expression was associated with the disease progression in patients with cervical cancer.
authors: Department of Obstetrics and Gynecology, Huangyan Hospital, Wenzhou Medical College, Huangyan, Zhejiang, China.
authors: Xiang-Juan
authors: XJ
authors: Li
authors: Xia
authors: X
authors: Zhang
authors: Aifen
authors: A
authors: Lin
authors: Yan-Yun
authors: YY
authors: Ruan
authors: Wei-Hua
authors: WH
authors: Yan
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D059951:HLA-G Antigens / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D059951:HLA-G Antigens