title: Telomere lengthening in CD8(+)cells in polyclonal in vitro stimulation is associated with an increase in protein content of catalytic subunit of telomerase (hTERT).
abstract: Culturing of polyclonally activated T lymphocytes for 7 days in vitro leads to telomere lengthening in CD8(+), but not CD4(+)lymphocytes. Under these conditions, CD8(+)lymphocytes more intensively express telomerase catalytic subunit protein (hTERT) and divide more often than CD4(+)lymphocytes. It changes the ratio of CD4(+)and CD8(+)subpopulations in favor of the latter by the end of culturing.
authors: Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. kvsiki@mail.ru
authors: V S
authors: VS
authors: Kozhevnikov
authors: V I
authors: VI
authors: Borisov
authors: O Yu
authors: OY
authors: Korolkova
authors: V A
authors: VA
authors: Kozlov
mesh_terms: D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D002478:Cells, Cultured; D006801:Humans; D008213:Lymphocyte Activation; D019098:Telomerase / Q000378:metabolism*; D059505:Telomere Homeostasis
chemical_list: C509186:TERT protein, human; D019098:Telomerase