title: Molecular and cellular mechanisms of pulmonary fibrosis.
abstract: Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most common and severe form of the disease, with a median survival of approximately three years and no proven effective therapy. Despite the fact that effective treatments are absent and the precise mechanisms that drive fibrosis in most patients remain incompletely understood, an extensive body of scientific literature regarding pulmonary fibrosis has accumulated over the past 35 years. In this review, we discuss three broad areas which have been explored that may be responsible for the combination of altered lung fibroblasts, loss of alveolar epithelial cells, and excessive accumulation of ECM: inflammation and immune mechanisms, oxidative stress and oxidative signaling, and procoagulant mechanisms. We discuss each of these processes separately to facilitate clarity, but certainly significant interplay will occur amongst these pathways in patients with this disease.
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. ntodd@medicine.umaryland.edu.
authors: Nevins W
authors: NW
authors: Todd
authors: Irina G
authors: IG
authors: Luzina
authors: Sergei P
authors: SP
authors: Atamas