title: [Influenza virus reproduction in the endothelial cells of human blood vessels].
abstract: The current epidemic strains of the influenza subtypes Y5N1, H3N2, and H1N1 can be reproduced in the cultured human endothelial EAhy926 cells with an infective activity of 3.0-4.5 Ig TCD50. These findings were confirmed by the analysis of the autopsy material from patients who had died from influenza during the 2009-2010 epidemic, which showed influenza virus HA and NP proteins in the pulmonary blood vascular endothelium. The results obtained reflect a new aspect of the pathogenesis of influenza, which is important for the design of antiviral agents and for the development of combination therapy.
authors: I N
authors: IN
authors: Zhilinskaia
authors: A A
authors: AA
authors: Azarenok
authors: E V
authors: EV
authors: Il'inskaia
authors: A R
authors: AR
authors: Prochukhanova
authors: S L
authors: SL
authors: Vorob'ev
authors: E V
authors: EV
authors: Sorokin
authors: T R
authors: TR
authors: Tsareva
mesh_terms: D004730:Endothelium, Vascular / Q000648:ultrastructure / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification / Q000502:physiology*; D053122:Influenza A Virus, H3N2 Subtype / Q000302:isolation & purification / Q000502:physiology*; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification / Q000502:physiology*; D007251:Influenza, Human / Q000821:virology*; D008168:Lung / Q000473:pathology / Q000821:virology; D008854:Microscopy, Electron; D019562:Viral Load; D014764:Viral Proteins / Q000276:immunology; D014779:Virus Replication
chemical_list: D014764:Viral Proteins