title: Estimated prevalence of canine Type 2 Von Willebrand disease in the Deutsch-Drahthaar (German Wirehaired Pointer) in Europe.
abstract: Type 2 Von Willebrand disease (VWD) is a severe coagulopathy occurring in the Deutsch-Drahthaar dog (or German Wirehaired Pointer, DD/GWP). Recently, a causative recessive mutation has been identified, and a DNA test is now available for individual screening. The genotype distribution (clear, carrier, and affected dogs) was investigated in 1855 DD/GWP dogs using data collected by the DD DNA-VWD-Databank in several European countries. 1704 (91.8%) DD/GWP dogs were genotypically clear of the VWD mutation, 144 (7.8%) were carriers, and seven (0.4%) were affected. The estimated disease allele frequency was highest in Germany and Sweden (almost 5%), and about 1% in Denmark, Finland and Norway. The Hardy-Weinberg equilibrium was tested in the German sample, and showed no evidence of deviation.
authors: Department of Veterinary Clinic, University of Pisa, Pisa, Italy. agavazza@vet.unipi.it
authors: Alessandra
authors: A
authors: Gavazza
authors: Silvano
authors: S
authors: Presciuttini
authors: Hans
authors: H
authors: Keuper
authors: George
authors: G
authors: Lubas
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D005060:Europe / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D015995:Prevalence; D056728:von Willebrand Disease, Type 2 / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*