title: Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders.
abstract: BACKGROUND
  Anxiety is common in stroke survivors and may adversely affect recovery. Polymorphisms of tryptophan hydroxylase2 (THP2) gene have been shown to be associated with anxiety disorders and other affective disorders. This study was aimed to investigate the association of two polymorphisms of THP2 gene, rs4570625 and rs4565946, with poststroke anxiety disorders in a Han Chinese population.
  
  
  METHODS
  This case control study included 112poststroke anxiety patients and 246 non-anxious controls. All participants completed Hamilton Anxiety Rating Scale and DNA was extracted from blood and genotyped for the two polymorphisms of THP2 gene.
  
  
  RESULTS
  Results revealed that the G allele of rs4570625 was associated with the increased risk of poststroke anxiety. In the female subgroup, both the GG genotype and G allele were observed to be significantly higher in case than in control. No significant difference in genotype and allele frequencies of the rs4565946 was found between case and control. Haplotype analysis identified that patients with the G-C haplotype had significantly increased the risk of poststroke anxiety.
  
  
  CONCLUSIONS
  More than 20 TPH2 polymorphisms have been detected, some of which are tightly-linked and may function together, only two SNPs of TPH2 were investigated in this study.
  
  
  CONCLUSIONS
  The findings suggest that these polymorphisms in TPH2 gene are involved in development of poststroke anxiety in the Han Chinese population.
authors: Department of Neurology, The Affiliated Hospital of Medical College, Qingdao University, No 16, Jiangsu Road, Qingdao, Shandong Province 266003, China.
authors: Song
authors: S
authors: Chi
authors: Lei
authors: L
authors: Teng
authors: Jing-Hui
authors: JH
authors: Song
authors: Chang
authors: C
authors: Zhou
authors: Wei-Hua
authors: WH
authors: Pan
authors: Ren-Liang
authors: RL
authors: Zhao
authors: Chen
authors: C
authors: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D001008:Anxiety Disorders / Q000208:ethnology* / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D020521:Stroke / Q000208:ethnology* / Q000235:genetics; D017741:Survivors / Q000523:psychology* / Q000706:statistics & numerical data; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D004247:DNA; D014365:Tryptophan Hydroxylase