title: Can activation of coagulation and impairment of fibrinolysis in patients with anxiety and depression be reversed after improvement of psychiatric symptoms? Results of a pilot study.
abstract: Anxiety and depression are associated with an activation of coagulation and impairment of fibrinolysis. This study addresses the question whether these findings are reversed after psychotherapy and improvement of psychiatric symptoms. Three factors of coagulation and fibrinolysis as well as level of anxiety and depression were reassessed in 12 patients 1 to 3 years after intensive inpatient psychotherapy. The patients showed a substantial improvement of their severe anxiety disorder and comorbid depressive disorder. Simultaneously, we found a significant decrease in factor VII and plasminogen activator inhibitor. We conclude that reduction of severe anxiety and depression may be associated with a reversal of the procoagulant effect (activation of coagulation and impairment of fibrinolysis) of these psychological states. Because of the small sample size of this pilot study, further research is needed.
authors: Clinic for Psychosomatic Medicine and Psychotherapy, University of Bonn, Germany. franziska.geiser@ukb.uni-bonn.de
authors: Franziska
authors: F
authors: Geiser
authors: Katharina
authors: K
authors: Gessler
authors: Rupert
authors: R
authors: Conrad
authors: Katrin
authors: K
authors: Imbierowicz
authors: Christian
authors: C
authors: Albus
authors: Ursula
authors: U
authors: Harbrecht
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood* / Q000150:complications / Q000523:psychology / Q000628:therapy; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000523:psychology* / Q000628:therapy; D003866:Depressive Disorder / Q000097:blood* / Q000150:complications / Q000523:psychology / Q000628:therapy; D005167:Factor VII / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015849:Plasminogen Inactivators / Q000097:blood; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D016896:Treatment Outcome
chemical_list: D015849:Plasminogen Inactivators; D005167:Factor VII