title: [Cellular composition and regulatory function of fetal liver stroma].
abstract: Hematopoietic differentiation and formation of hepatic tissue both take place in mammalian liver during its prenatal development. Hematopoietic and hepatic stem cells self-renew, proliferate and differentiate within specific microenvironment that is organized by stromal elements. Stroma of developing liver consists of different cell populations such as mesenchymal stromal cells, Ito cells, portal fibroblasts and myofibroblasts, vascular endothelial and smooth muscle cells, cells undergoing epithelial-to-mesenchymal transition. In this review, their phenotypical and functional properties, possible derivation and role in the regulation of hematopoiesis and hepatogenesis are discussed.
authors: O V
authors: OV
authors: Paiushina
authors: E I
authors: EI
authors: Domaratskaia
authors: V I
authors: VI
authors: Starostin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D058750:Epithelial-Mesenchymal Transition; D005333:Fetus; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000254:growth & development; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000502:physiology; D058628:Myofibroblasts / Q000166:cytology / Q000502:physiology