title: Enantioselective synthesis of chiral sulfones by Ir-catalyzed asymmetric hydrogenation: a facile approach to the preparation of chiral allylic and homoallylic compounds.
abstract: A highly efficient and enantioselective Ir-catalyzed hydrogenation of unsaturated sulfones was developed. Chiral cyclic and acyclic sulfones were produced in excellent enantioselectivities (up to 98% ee). Coupled with the Ramberg-Bäcklund rearrangement, this reaction offers a novel route to chiral allylic and homoallylic compounds in excellent enantioselectivities (up to 97% ee) and high yields (up to 94%).
authors: Department of Chemistry-BMC, Uppsala University, Box 576, S-75123 Uppsala, Sweden.
authors: Taigang
authors: T
authors: Zhou
authors: Byron
authors: B
authors: Peters
authors: Matías F
authors: MF
authors: Maldonado
authors: Thavendran
authors: T
authors: Govender
authors: Pher G
authors: PG
authors: Andersson
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000498:Allyl Compounds; D013450:Sulfones; D007495:Iridium