title: Biomimetic semisynthesis of arglabin from parthenolide.
abstract: The semisynthesis of arglabin, an anticancer drug in clinical application, is developed from abundant natural product parthenolide via three steps. Each step in this sequence is highly stereoselective, and the substrate-dependent stereoselectivity in the epoxidation step can be explained by computational calculations. The success of chemical semisynthesis of arglabin suggests that the biosynthesis of arglabin might proceed in a similar pathway.
authors: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, PR China.
authors: Jia-Dai
authors: JD
authors: Zhai
authors: Dongmei
authors: D
authors: Li
authors: Jing
authors: J
authors: Long
authors: Hao-Liang
authors: HL
authors: Zhang
authors: Jian-Ping
authors: JP
authors: Lin
authors: Chuan-Jiang
authors: CJ
authors: Qiu
authors: Quan
authors: Q
authors: Zhang
authors: Yue
authors: Y
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D032701:Biomimetics; D006801:Humans; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C002669:parthenolide; C083346:arglabin