title: Exploring the biological activities of Echeveria leucotricha.
abstract: Echeveria leucotricha J. A. Purpus (Crassulaceae) was evaluated for its potential antibacterial, antifungal, antiparasitic, cytotoxic and anti-inflammatory bioactivities. Aerial parts were extracted with hexane, methanol and chloroform, and fractionated accordingly. Biological activity was assessed in vitro against five Gram-positive and four Gram-negative bacteria, four human pathogenic fungi and the protozoan Leishmania donovani. Extracts and fractions showing bioactivities were further investigated for their cytotoxic activities on macrophages. Results show that several extracts and fractions exhibited significant antibacterial, antifungal, and antiparasitic activities, but no anti-inflammatory activity was recorded. Here, we report for the first time, and to the best of our knowledge, these bioactivities, which suggest that this plant can be used in the traditional Mexican medicine.
authors: Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.
authors: María G
authors: MG
authors: Martínez Ruiz
authors: Anaximandro
authors: A
authors: Gómez-Velasco
authors: Zaida N
authors: ZN
authors: Juárez
authors: Luis R
authors: LR
authors: Hernández
authors: Horacio
authors: H
authors: Bach
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D029627:Crassulaceae / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008519:Medicine, Traditional; D008800:Mexico; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000977:Antiparasitic Agents; D010936:Plant Extracts