title: Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
authors: USTHB, Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric oxide synthases, Immunity and pathogeny, Bab-Ezzouar, Algiers, Algeria. mbourouba@usthb.dz
authors: Mehdi
authors: M
authors: Bourouba
authors: Aziza
authors: A
authors: Boukercha
authors: Ahmed-Amine
authors: AA
authors: Zergoun
authors: Abderezak
authors: A
authors: Zebboudj
authors: Mohamed
authors: M
authors: Elhadjan
authors: Djamel
authors: D
authors: Djenaoui
authors: Fatima
authors: F
authors: Asselah
authors: Chafia
authors: C
authors: Touil-Boukoffa
mesh_terms: D000293:Adolescent; D000328:Adult; D000462:Algeria; D002277:Carcinoma / Q000097:blood* / Q000473:pathology / Q000628:therapy; D016022:Case-Control Studies; D006801:Humans; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology / Q000517:prevention & control; D009569:Nitric Oxide / Q000097:blood*; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D009569:Nitric Oxide