title: Platinum-based combination chemotherapy for the treatment of advanced-stage squamous cell carcinoma of the vulva.
abstract: BACKGROUND
  Chemoradiation is an alternative to radical vulvectomy with en bloc node dissection for advanced vulvar cancer. We report a case of complete clinical and pathologic response with chemotherapy alone in a patient with advanced vulvar cancer.
  
  
  METHODS
  A middle-aged woman known to have had human immunodeficiency virus (HIV) for 10 years was newly diagnosed with advanced-stage squamous carcinoma of the vulva. She was treated with a total of nine cycles of platinum-based combination chemotherapy, with complete clinical and pathologic response. She remains in complete clinical remission without evidence of recurrent disease by noninvasive testing in the absence of any further therapy 24 months after her last chemotherapy treatment.
  
  
  CONCLUSIONS
  Platinum-based combination chemotherapy may be used successfully for patients with advanced-stage squamous carcinoma of the vulva.
authors: From the Departments of Obstetrics and Gynecology and Pathology, Wayne State University, the Detroit Medical Center, the Karmanos Cancer Institute, and the Wayne State University School of Medicine, Detroit, Michigan.
authors: Jimmy
authors: J
authors: Belotte
authors: Awoniyi O
authors: AO
authors: Awonuga
authors: Rashmi
authors: R
authors: Bolinjkar
authors: Mitchell
authors: M
authors: Alexis
authors: Farah
authors: F
authors: Tabassum
authors: Gunter
authors: G
authors: Deppe
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin