title: Comparison of lidocaine metabolism for different anesthesia techniques in rabbits with liver disease.
abstract: OBJECTIVE
  This study was designed to investigate the serum lidocaine concentrations (SLC) after local infiltration anesthesia (IA) and mandibular anesthesias (MA) in rabbits with carbon tetrachloride (CCl₄)-induced chronic liver damage (CLD).
  
  
  METHODS
  Fourteen rabbits were administered CCl₄ in group 1, MA (CLD-MA; n = 7); in group 2, IA (CLD-IA; n = 7); in group 3, MA (H-MA; n = 7); and in group 4, IA (H-IA; n = 6) was performed. SLC were measured.
  
  
  RESULTS
  SLC showed difference over time. At the 10th minute, mean SLC in IA groups were higher than in MA groups. At the 120th minute, the highest mean concentration was found in the CLD-IA group.
  
  
  CONCLUSIONS
  SLC increases in CLD, and serum lidocaine concentration after IA in the mandibular anterior region is higher than it is after MA.
authors: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri, Turkey. ncelebi@erciyes.edu.tr
authors: Nükhet
authors: N
authors: Çelebi
authors: Mehtap
authors: M
authors: Muğlalı
authors: Abdurrahman
authors: A
authors: Aksoy
authors: Gül
authors: G
authors: Yarım
authors: Murat
authors: M
authors: Yarım
authors: Dilek
authors: D
authors: Güvenç
mesh_terms: D000704:Analysis of Variance; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000009:adverse effects / Q000097:blood*; D000818:Animals; D058625:End Stage Liver Disease / Q000139:chemically induced* / Q000150:complications; D008012:Lidocaine / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008334:Mandible; D011817:Rabbits
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine