title: Design and evaluation of chitosan nanoparticles as novel drug carrier for the delivery of rivastigmine to treat Alzheimer's disease.
abstract: OBJECTIVE
  The objective of the study was to develop chitosan nanoparticles of the drug rivastigmine and to study the effect of polysorbate 80 coating on its biodistribution.
  
  
  RESULTS
  Chitosan nanoparticles containing rivastigmine were prepared by spontaneous emulsification. The mean size of the particles was 47 +/- 4 nm. Zeta potential analysis demonstrated a positive charge for the particles and coating with polysorbate 80 slightly reduced the surface charge of the particles. A biphasic release pattern was observed for the release of drug from the nanoparticles. Release of the drug from nanoparticles was diffusion controlled and the mechanism of drug release was Fickian.
  
  
  CONCLUSIONS
  The biodistribution studies demonstrated that coating of nanoparticles with 1% polysorbate 80 altered the uptake of nanoparticles by different organs.
authors: Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka-560078, India. b_wilson@rediffmail.com
authors: Barnabas
authors: B
authors: Wilson
authors: Malay K
authors: MK
authors: Samanta
authors: Madaswamy S
authors: MS
authors: Muthu
authors: Ganesan
authors: G
authors: Vinothapooshan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D048271:Chitosan / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D004337:Drug Carriers; D004355:Drug Stability; D053758:Nanoparticles / Q000008:administration & dosage*; D010316:Particle Size; D048448:Phenylcarbamates / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D000068836:Rivastigmine; D012995:Solubility; D014018:Tissue Distribution
chemical_list: D002800:Cholinesterase Inhibitors; D004337:Drug Carriers; D048448:Phenylcarbamates; D048271:Chitosan; D000068836:Rivastigmine