title: Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus.
abstract: Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.
authors: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
authors: Magdalena M
authors: MM
authors: van der Kooi-Pol
authors: Ewoud
authors: E
authors: Reilman
authors: Mark J J B
authors: MJ
authors: Sibbald
authors: Yanka K
authors: YK
authors: Veenstra-Kyuchukova
authors: Thijs R H M
authors: TR
authors: Kouwen
authors: Girbe
authors: G
authors: Buist
authors: Jan Maarten
authors: JM
authors: van Dijl
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D015870:Gene Expression; D008565:Membrane Proteins / Q000378:metabolism*; D011490:Protein Disulfide Reductase (Glutathione) / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D011490:Protein Disulfide Reductase (Glutathione); D012697:Serine Endopeptidases; C026515:type I signal peptidase