title: [Expression of transmitter receptor genes in early development of sea urchin Paracentrotus lividus].
abstract: Neurotransmitters (including serotonin and acetylcholine) perform a number of prenervous functions in early sea urchin development. To detect the particular receptor components involved in these processes, we carried out a database search and nucleotide sequences homologous to serotonin receptor type 4, and the alpha6- and alpha10-subunits of nicotinic acetylcholine receptor were found among EST-clones from early Paracentrotus lividus embryos. Expression of these transcripts during early development was demonstrated using RT-PCR. These results are the first molecular biology evidence ofserotonin and acetylcholine receptor expression in sea urchin early embryogenesis.
authors: D A
authors: DA
authors: Nikishin
authors: M N
authors: MN
authors: Semenova
authors: Iu B
authors: IuB
authors: Shmukler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004625:Embryo, Nonmammalian; D020224:Expressed Sequence Tags; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D047328:Paracentrotus / Q000196:embryology* / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*; D044422:Receptors, Serotonin, 5-HT4 / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D011978:Receptors, Nicotinic; C104518:nicotinic receptor alpha6; D044422:Receptors, Serotonin, 5-HT4