title: Neurocognitive alterations in first degree relatives of suicide completers.
abstract: BACKGROUND
  Suicide aggregates within families and the relatives of suicide completers are at an increased risk for suicide. Though neurocognitive changes are gaining increasing attention as part of the vulnerability for suicide, the literature on neurocognitive alterations among suicide relatives as possible endophenotypes of suicide is sparse.
  
  
  METHODS
  Normothymic first-degree relatives (n=14) of suicide completers without personal histories of suicide attempts were compared to individuals without family histories of suicide (n=14) matched for age-, sex- and education. Participants completed the Wisconsin card sorting test, a well validated test of cognitive control in a changing environment.
  
  
  RESULTS
  First-degree relatives of suicide completers made significantly more perseverative errors and have a lower level of conceptual responses than comparison subjects.
  
  
  CONCLUSIONS
  Alterations found in first-degree relatives of suicide completers suggest a decreased responsiveness to changing, yet unambiguous, conditions. These neurocognitive impairments are similar to deficits observed among individuals engaging in suicide attempts. Neurocognitive impairments revealed by the Wisconsin card sorting test may represent a neurocognitive endophenotype of suicide.
authors: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Blvd., Montreal, QC, Canada H4H 1R3. alexander.mcgirr@alum.utoronto.ca
authors: Alexander
authors: A
authors: McGirr
authors: Fabrice
authors: F
authors: Jollant
authors: Gustavo
authors: G
authors: Turecki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis*; D009483:Neuropsychological Tests; D009679:Nuclear Family / Q000523:psychology*; D018570:Risk Assessment / Q000379:methods; D013405:Suicide