title: The effects of dietary fatty acid composition in the post-sucking period on metabolic alterations in adulthood: can ω3 polyunsaturated fatty acids prevent adverse programming outcomes?
abstract: Early life nutrition is important in the regulation of metabolism in adulthood. We studied the effects of different fatty acid composition diets on adiposity measures, glucose tolerance, and peripheral glucocorticoid (GC) metabolism in overfed neonatal rats. Rat litters were adjusted to a litter size of three (small litters (SLs)) or ten (normal litters (NLs)) on postnatal day 3 to induce overfeeding or normal feeding respectively. After weaning, SL and NL rats were fed a ω6 polyunsaturated fatty acid (PUFA) diet (14% calories as fat, soybean oil) or high-saturated fatty acid (high-fat; 31% calories as fat, lard) diet until postnatal week 16 respectively. SL rats were also divided into the third group fed a ω3 PUFA diet (14% calories as fat, fish oil). A high-fat diet induced earlier and/or more pronounced weight gain, hyperphagia, glucose intolerance, and hyperlipidemia in SL rats compared with NL rats. In addition, a high-fat diet increased 11β-hsd1 (Hsd11b1) mRNA expression and activity in the retroperitoneal adipose tissue of both litter groups compared with standard chow counterparts, whereas high-fat feeding increased hepatic 11β-hsd1 mRNA expression and activity only in SL rats. SL and a high-fat diet exhibited significant interactions in both retroperitoneal adipose tissue and hepatic 11β-HSD1 activity. Dietary ω3 PUFA offered protection against glucose intolerance and elevated GC exposure in the retroperitoneal adipose tissue and liver of SL rats. Taken together, the results suggest that dietary fatty acid composition in the post-sucking period may interact with neonatal feeding and codetermine metabolic alterations in adulthood.
authors: Department of Child Health Care, Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, People's Republic of China.
authors: Miao
authors: M
authors: Hou
authors: Chenlin
authors: C
authors: Ji
authors: Jing
authors: J
authors: Wang
authors: Yanhua
authors: Y
authors: Liu
authors: Bin
authors: B
authors: Sun
authors: Mei
authors: M
authors: Guo
authors: Jonas
authors: J
authors: Burén
authors: Xiaonan
authors: X
authors: Li
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D004041:Dietary Fats / Q000032:analysis / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D048788:Growth and Development / Q000187:drug effects / Q000502:physiology; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis / Q000517:prevention & control*; D008660:Metabolism / Q000187:drug effects*; D011247:Pregnancy; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014886:Weaning
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3