title: In silico design, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia".
abstract: With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.
authors: School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
authors: Genzoh
authors: G
authors: Tanabe
authors: Shinya
authors: S
authors: Nakamura
authors: Nozomi
authors: N
authors: Tsutsui
authors: Gorre
authors: G
authors: Balakishan
authors: Weijia
authors: W
authors: Xie
authors: Satoshi
authors: S
authors: Tsuchiya
authors: Junji
authors: J
authors: Akaki
authors: Toshio
authors: T
authors: Morikawa
authors: Kiyofumi
authors: K
authors: Ninomiya
authors: Isao
authors: I
authors: Nakanishi
authors: Masayuki
authors: M
authors: Yoshikawa
authors: Osamu
authors: O
authors: Muraoka
mesh_terms: D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D049918:Salacia / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013431:Sulfates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000737:chemistry / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013402:Sugar Alcohols; D013431:Sulfates; C427963:salacinol; D000520:alpha-Glucosidases