title: Human UDP-glucuronosyltransferases: feedback loops between substrates and ligands of their transcription factors.
abstract: Expression profiles of human adult and fetal hepatic and intestinal UDP-glucuronosyltransferases (UGTs), information about their endo- and xenobiotic substrates, and their transcriptional regulation suggests regulatory circuits between some UGT substrates and ligands of their transcription factors. For examples: (i) bilirubin is solely conjugated by UGT1A1 and activates its transcription factors Ah receptor, PXR and CAR. (ii) Hepatotoxic lithocholic acid (LCA) is oxidized to hyodeoxycholic acid, the latter conjugated by UGT2B4 and UGT2B7. LCA is also an agonist of FXR and PPARα, which are controlling these UGTs. (iii) Similar feedback loops possibly exist between some eicosanoids, PPARα and UGTs. (iv) Regulatory circuits may also have evolved between dietary polyphenols, which are efficient substrates of UGTs and activators of the Ah receptor. Although many newly developed drugs are conjugated by promiscuous UGTs, the discussed regulatory circuits may provide hints to evolutionary important UGT substrates.
authors: Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Wilhelmstrasse 56, D-72074 Tübingen, Germany. bock@uni-tuebingen.de
authors: Karl Walter
authors: KW
authors: Bock
mesh_terms: D004789:Enzyme Activation; D014453:Glucuronosyltransferase / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D008024:Ligands; D014157:Transcription Factors; D014453:Glucuronosyltransferase