title: A short overview on the medicinal chemistry of (-)-shikimic acid.
abstract: Shikimic acid, a natural compound is a key intermediate in the biosynthesis of amino acids. Consequently, this derivative is widely present in many plants and has interesting biological properties. But besides the pharmacological relevance of shikimic acid itself, it is also an intermediate in the synthesis of many drugs, being the most relevant the antiviral agent oseltamivir (Tamiflu™). Here we present a short overview on recent natural, biotechnological and synthetical sources of shikimic acid, togheter with pharmacological applications of this compound and a selection of derivatives, including oseltamivir (Tamiflu™).
authors: Departamento de Química Orgánica (Facultade de Química) and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Campus Vida, Universidade de Santiago de Compostela, Jenaro de la Fuente s/n, 15782, Santiago de Compostela, Spain.
authors: Amalia M
authors: AM
authors: Estévez
authors: Ramón J
authors: RJ
authors: Estévez
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D001709:Biotechnology / Q000379:methods; D055808:Drug Discovery; D006801:Humans; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D053139:Oseltamivir / Q000737:chemistry / Q000494:pharmacology; D012765:Shikimic Acid / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D053139:Oseltamivir; D012765:Shikimic Acid; D009439:Neuraminidase