title: Olfaction under metabolic influences.
abstract: Recently published work and emerging research efforts have suggested that the olfactory system is intimately linked with the endocrine systems that regulate or modify energy balance. Although much attention has been focused on the parallels between taste transduction and neuroendocrine controls of digestion due to the novel discovery of taste receptors and molecular components shared by the tongue and gut, the equivalent body of knowledge that has accumulated for the olfactory system, has largely been overlooked. During regular cycles of food intake or disorders of endocrine function, olfaction is modulated in response to changing levels of various molecules, such as ghrelin, orexins, neuropeptide Y, insulin, leptin, and cholecystokinin. In view of the worldwide health concern regarding the rising incidence of diabetes, obesity, and related metabolic disorders, we present a comprehensive review that addresses the current knowledge of hormonal modulation of olfactory perception and how disruption of hormonal signaling in the olfactory system can affect energy homeostasis.
authors: Centre de Recherche des Neurosciences de Lyon, Equipe Olfaction du Codage à la Mémoire, INSERM U 1028/CNRS 5292, Université de Lyon1, 50 Ave. Tony Garnier, 69366, Lyon, Cedex 07, France.
authors: Brigitte
authors: B
authors: Palouzier-Paulignan
authors: Marie-Christine
authors: MC
authors: Lacroix
authors: Pascaline
authors: P
authors: Aimé
authors: Christine
authors: C
authors: Baly
authors: Monique
authors: M
authors: Caillol
authors: Patrice
authors: P
authors: Congar
authors: A Karyn
authors: AK
authors: Julliard
authors: Kristal
authors: K
authors: Tucker
authors: Debra Ann
authors: DA
authors: Fadool
mesh_terms: D004734:Energy Metabolism; D041981:Gastrointestinal Tract / Q000502:physiology; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D012903:Smell
chemical_list: D006728:Hormones