title: [Hepcidin and diabetic anemia: is there an association?].
abstract: BACKGROUND
  Anemia is common in diabetes. The role of hepcidin in diabetic anemia is unknown.
  
  
  OBJECTIVE
  To assess the relationship between serum hepcidin and anemia in diabetic patients without renal failure.
  
  
  METHODS
  We prospectively studied 86 consecutive type II diabetic patients--39 with anemia (cases) and 47 without anemia (controls). Patients with renal failure, iron and vitamin B12 deficiency and chronic inflammatory diseases were excluded.
  
  
  RESULTS
  Univariate analyses showed that patients with anemia were older and had longer duration of diabetes compared to patients without anemia (P < 0.051). The median hepcidin level was 15 ng/mL (2-140 ng/ml) in patients with anemia compared to 14 ng/mL (2-128 ng/ml) in patients without anemia (P = 0.386]) Serum erythropoietin and creatinine levels were higher in patients with anemia compared to patients without anemia (P < 0.05). Patients with anemia had tower HbA1c levels (P = 0.035), and greater usage of anti-diabetic drugs; metformin 73% versus 46.8% (P = 0.016), and sulfonylurea 47.2% versus 19.1% (P = 0.006). After adjusting for age, the two groups still differed in duration of diabetes (P = 0.043), erythropoietin (P = 0.007) creatinine (P < 0.001), and usage of metformin, sulfonylurea and insulin (P < 0.05).
  
  
  CONCLUSIONS
  Subjects with diabetic anemia have Longer diabetes duration than subjects with diabetes without anemia. Based on the results of this small study, hepcidin was not associated with diabetic anemia.
authors: Medicine C, Ha'Emek Medical Center, Afuta, Israel. salibuss@yahoo.com
authors: Walid
authors: W
authors: Saliba
authors: Goldstein
authors: G
authors: Lee
authors: Naief
authors: N
authors: Habashi
authors: Mazen
authors: M
authors: Elias
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000740:Anemia / Q000209:etiology*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D004921:Erythropoietin / Q000097:blood; D005260:Female; D064451:Hepcidins; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007004:Hypoglycemic Agents; D004921:Erythropoietin; D003404:Creatinine