title: Presence of high-risk human papillomavirus genotype and human immunodeficiency virus DNA in anal high-grade and low-grade squamous intraepithelial lesions.
abstract: Human immunodeficiency virus type 1 (HIV)-infected individuals are at risk for anal cancer, which is caused by human papillomavirus (HPV). The relationship between HIV and HPV that leads to anal cancer remains unclear. Recent data, however, suggest that the continued persistence of HIV DNA in patients treated with combined antiretroviral therapy leads to progression of HIV disease and other HIV-associated complications. Therefore, we investigated the relationship among anal low- and high-grade squamous intraepithelial lesions (LGSIL/HGSIL), high-risk HPV genotypes, and high HIV DNA copy numbers. Anal cytology specimens were assayed for HPV genotype and HIV DNA copy number. High-risk HPV genotypes (odds ratio OR: 3.73; 95% confidence interval CI: 1.08-12.91; p=0.04) and high HIV DNA copy numbers (OR(per 100 HIV DNA copies): 1.13; 95% CI: 1.01-1.27, p=0.04) were both associated with LGSIL/HGSIL. When considering both high-risk HPV genotypes and HIV DNA copy numbers in predicting LGSIL/HGSIL, HIV DNA copy number was significant (OR(per 100 HIV DNA copies): 1.09; 95% CI: 0.96-1.23, p=0.04) but not high-risk HPV genotypes (OR: 2.30, p=0.28), which did not change when adjusted for nadir CD4 cell count and HIV RNA levels. The findings warrant further investigation of HIV DNA and its relationship with HPV in LGSIL/HGSIL pathogenesis.
authors: University of Hawaii, Hawaii Center of AIDS, Honolulu, HI 96813, USA. bshirami@hawaii.edu
authors: Bruce
authors: B
authors: Shiramizu
authors: Chin-Yuan
authors: CY
authors: Liang
authors: Melissa
authors: M
authors: Agsalda-Garcia
authors: Ian
authors: I
authors: Nagata
authors: Cris
authors: C
authors: Milne
authors: Xuemei
authors: X
authors: Zhu
authors: Jeffrey
authors: J
authors: Killeen
authors: J Michael
authors: JM
authors: Berry
authors: Marc T
authors: MT
authors: Goodman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000473:pathology / Q000821:virology; D001005:Anus Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D060085:Coinfection / Q000235:genetics / Q000821:virology; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications* / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology / Q000821:virology*; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004279:DNA, Viral