title: Does phage P22 contribute to resistance of Salmonella to oxidative stress?
abstract: Resistance to oxidative stress belongs to key virulence factors of bacterial pathogens including Salmonella. Typing of prophages in the genome is used to identify individual Salmonella strains. Some of the prophages and prophage remnants contain genes coding for important and metabolically active enzymes. We hypothesize that antioxidative status of the host Salmonella is affected by the bactoprenol glucosyltransferase (gtrB) from the P22 phage and that this effect is mediated by enhanced production of antioxidative selenoproteins. Our hypothesis is testable using targeted bacterial mutants exposed to oxidative stress in vivo and in vitro.
authors: Department of Molecular Biology, Comenius University, Bratislava, Slovakia.
authors: Tomáš
authors: T
authors: Szemes
authors: Barbora
authors: B
authors: Vlková
authors: Gabriel
authors: G
authors: Minárik
authors: Hana
authors: H
authors: Drahovská
authors: Ján
authors: J
authors: Turňa
authors: Peter
authors: P
authors: Celec
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D017100:Bacteriophage P22 / Q000235:genetics / Q000378:metabolism*; D005814:Genes, Viral; D005964:Glucosyltransferases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018384:Oxidative Stress; D012475:Salmonella / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity / Q000821:virology*; D051140:Selenoproteins / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D000975:Antioxidants; D051140:Selenoproteins; D013729:Terpenes; D014764:Viral Proteins; C000146:bactoprenol; D005964:Glucosyltransferases