title: Asymmetric formal carbonyl-ene reactions of formaldehyde tert-butyl hydrazone with α-keto esters: dual activation by bis-urea catalysts.
abstract: The dual activation of α-keto esters and formaldehyde tert-butyl hydrazone by BINAM-derived bis-ureas is the key to achieve high reactivity and excellent enantioselectivities in nucleophilic addition (formal carbonyl-ene reaction) to functionalized tertiary carbinols. Ensuing high-yielding diazene-to-aldehyde tranformations and subsequent derivatizations provides a direct entry to a variety of densely functionalized products.
authors: Instituto Investigaciones Químicas (CSIC-US), C/Américo Vespucio, 49, 41092 Sevilla, Spain.
authors: Ana
authors: A
authors: Crespo-Peña
authors: David
authors: D
authors: Monge
authors: Eloísa
authors: E
authors: Martín-Zamora
authors: Eleuterio
authors: E
authors: Alvarez
authors: Rosario
authors: R
authors: Fernández
authors: José M
authors: JM
authors: Lassaletta