title: Efficacy of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naïve HIV-1-infected patients: week-192 overall and subgroup analyses from STARTMRK.
abstract: We compared 4 years of antiretroviral therapy with tenofovir/emtricitabine and either raltegravir or efavirenz from the ongoing STARTMRK study of treatment-naïve HIV-infected patients. Through 192 weeks, raltegravir produced durable and consistent viral suppression and immune restoration compared with efavirenz irrespective of baseline demographic and prognostic factors, including in patients with high viral loads.
authors: Orlando Immunology Center, Orlando, Florida, USA.
authors: Edwin
authors: E
authors: DeJesus
authors: Jürgen K
authors: JK
authors: Rockstroh
authors: Jeffrey L
authors: JL
authors: Lennox
authors: Michael S
authors: MS
authors: Saag
authors: Adriano
authors: A
authors: Lazzarin
authors: Jing
authors: J
authors: Zhao
authors: Hong
authors: H
authors: Wan
authors: Anthony J
authors: AJ
authors: Rodgers
authors: Monica L
authors: ML
authors: Walker
authors: Michael
authors: M
authors: Miller
authors: Mark J
authors: MJ
authors: DiNubile
authors: Bach-Yen
authors: BY
authors: Nguyen
authors: Hedy
authors: H
authors: Teppler
authors: Randi
authors: R
authors: Leavitt
authors: Peter
authors: P
authors: Sklar
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000293:Adolescent; D000328:Adult; D000368:Aged; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D048588:Benzoxazines / Q000008:administration & dosage; D018791:CD4 Lymphocyte Count; D003521:Cyclopropanes; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D000068679:Emtricitabine; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000008:administration & dosage; D011760:Pyrrolidinones / Q000008:administration & dosage; D000068898:Raltegravir Potassium; D000068698:Tenofovir
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D063065:Organophosphonates; D011760:Pyrrolidinones; D003841:Deoxycytidine; D000068898:Raltegravir Potassium; D000068698:Tenofovir; D000068679:Emtricitabine; D000225:Adenine; C098320:efavirenz