title: Association between gingival crevicular fluid prostaglandin E ₂ level and preterm low birth weight.
abstract: BACKGROUND
  Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E ₂ (PGE ₂), may pose a threat to the fetal-placental unit and cause preterm delivery.
  
  
  OBJECTIVE
  This study was conducted to estimate the PGE 2 levels in gingival crevicular fluid (GCF) and to explore the association between GCF-PGE ₂ levels and preterm low birth weight (PLBW).
  
  
  METHODS
  Twenty-two pregnant patients were selected for the study. GCF samples were collected from these patients before delivery and again at 1 month after delivery. PGE ₂ level was estimated using a commercially available ELISA kit (Neogen).
  
  
  RESULTS
  The mean GCF-PGE ₂ level was 5.8 ng/ml before parturition and 5.5 ng/ml after parturition, but the difference was not statistically significant. There was negative correlation between PGE ₂ levels and gestational age at birth.
  
  
  CONCLUSIONS
  The study provides weak evidence that there is correlation between GCF-PGE ₂ levels and birth outcome. Further clinical trials with large samples are required to confirm the association between GCF-PGE ₂ levels and PLBW.
authors: Department of Periodontics, MR Ambedkar Dental College and Hospital, Bangalore, Karnataka, India.
authors: Fouzia
authors: F
authors: Tarannum
authors: Mohamed
authors: M
authors: Faizuddin
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D015232:Dinoprostone / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009911:Oral Hygiene Index; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D011247:Pregnancy / Q000378:metabolism*; D011256:Pregnancy Outcome; D047928:Premature Birth; D055815:Young Adult
chemical_list: D015232:Dinoprostone