title: High expression of miR-210 predicts poor survival in patients with breast cancer: a meta-analysis.
abstract: BACKGROUND
  Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.
  
  
  METHODS
  A meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  A total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04-5.63, P<0.05), which could significantly predict poorer survival.
  
  
  CONCLUSIONS
  High expression of miR-210 might predict poor survival in patients with breast cancer.
authors: Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. hongliu180@126.com
authors: Liu
authors: L
authors: Hong
authors: Jianjun
authors: J
authors: Yang
authors: Yu
authors: Y
authors: Han
authors: Qun
authors: Q
authors: Lu
authors: Jun
authors: J
authors: Cao
authors: Labiq
authors: L
authors: Syed
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D016016:Proportional Hazards Models; D012334:RNA, Neoplasm / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs; D012334:RNA, Neoplasm