title: Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
abstract: 30 novel compounds have been synthesized from 25-hydroxyprotopanaxadiol (25-OH-PPD) and their in vitro anti-tumor activities were tested on three cancer cell lines and one normal cell line (IOSE144) by standard MTT assay. The results showed that compound 27 exhibited the best anti-tumor activity in the in vitro assays. Compounds 1, 2, 16, 17, 18, 27, 28 and 29 have better anti-tumor activities against MCF-7 and A549 cancer cell lines than 25-OH-PPD, together with low toxicity in the normal cell. The results may provide useful data for researching and developing new antitumor agents.
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang 110016, PR China.
authors: Peng
authors: P
authors: Wang
authors: Xiu-Li
authors: XL
authors: Bi
authors: Yu-Mei
authors: YM
authors: Guo
authors: Jia-Qing
authors: JQ
authors: Cao
authors: Shi-Jun
authors: SJ
authors: Zhang
authors: Hao-Nan
authors: HN
authors: Yuan
authors: Hu-Ri
authors: HR
authors: Piao
authors: Yu-Qing
authors: YQ
authors: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D036145:Ginsenosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: C529607:25-hydroxyprotopanaxadiol; D000970:Antineoplastic Agents; D036145:Ginsenosides