title: Multiple tests of cost-effectiveness angles.
abstract: Cost-effectiveness angles are an attractive measure of performance when comparing effects and costs of health-care therapies because they have a clear interpretation and are well suited for statistical inference. In clinical trials, a common setup is the comparison of multiple new therapies with a single control. If cost-effectiveness angles are calculated for each comparison, multiplicity issues should be taken into account when quantifying uncertainty of the point estimates. Therefore, this paper proposes a parametric test for multiple cost-effectiveness angles that guarantees strong family-wise error rate control. The idea is to replace the test of m cost-effectiveness angles as a union-intersection test of 3m linear hypotheses. Considering the correlation structure of the individual test statistics for the linear hypotheses leads to a maximum-type test for the intersection hypothesis. Inverting these test decisions then gives simultaneous CIs of cost-effectiveness angles with the appropriate coverage probabilities.
authors: Department of Mathematics, University of Bremen, Germany. georg.gutjahr@math.uni-bremen.de
authors: G
authors: G
authors: Gutjahr
authors: W
authors: W
authors: Brannath
mesh_terms: D056808:Biostatistics; D002986:Clinical Trials as Topic / Q000191:economics* / Q000706:statistics & numerical data; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data*; D017048:Health Care Costs / Q000706:statistics & numerical data; D006801:Humans; D016014:Linear Models; D015233:Models, Statistical; D016032:Randomized Controlled Trials as Topic / Q000191:economics / Q000706:statistics & numerical data