title: Living donor vs. deceased donor liver transplantation for patients with hepatitis C virus-related diseases.
abstract: OBJECTIVE
  Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LDLT remain controversial. Here we sought to compare the post-transplant outcomes after LDLT and DDLT.
  
  
  METHODS
  A systematic review and meta-analysis were performed. PubMed/MEDLINE, EMBASE, and the Cochrane database were searched for eligible literatures. The major end points were patient survival, graft survival, recurrence rate, and acute rejection. The pooled odds ratio (OR) was calculated using random-effects model to synthesize the results. Heterogeneity and publication bias were quantitatively evaluated.
  
  
  RESULTS
  Fourteen studies with a total of 2024 participants were included in this analysis. We found comparable patient survival between groups (1-year: OR, 0.78, 95% CI, 0.48-1.26, p=0.31; 2-year: OR, 0.71, 95% CI, 0.41-1.23, p=0.23; 3-year: OR, 0.79, 95% CI, 0.5-1.12, p=0.18; 4-year: OR, 0.92, 95% CI, 0.43-1.95, p=0.83; 5-year: OR, 1.06, 95% CI, 0.53-2.14, p=0.86, respectively). Although 1- and 3-year graft survivals were inferior in LDLT, 2-, 4- and 5-year graft survivals were similar. HCV recurrence rates and acute rejection rates were equivalent.
  
  
  CONCLUSIONS
  LDLT was equivalent to DDLT in terms of patient survival, long-term graft survival, HCV recurrence, and acute rejection rates, with potentially lower short-term patient and graft survival.
authors: Department of General Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors: Anbin
authors: A
authors: Hu
authors: Wenhua
authors: W
authors: Liang
authors: Zheng
authors: Z
authors: Zheng
authors: Zhiyong
authors: Z
authors: Guo
authors: Xiaoshun
authors: X
authors: He
mesh_terms: D002102:Cadaver; D006084:Graft Rejection; D006085:Graft Survival; D006526:Hepatitis C / Q000150:complications / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality; D019520:Living Donors; D017594:Publication Bias; D012008:Recurrence