title: The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms.
abstract: The serotonin (5-HT) hypothesis of depression dates from the 1960s. It originally postulated that a deficit in brain serotonin, corrected by antidepressant drugs, was the origin of the illness. Nowadays, it is generally accepted that recurring mood disorders are brain diseases resulting from the combination, to various degrees, of genetic and other biological as well as environmental factors, evolving through the lifespan. All areas of neuroscience, from genes to behaviour, molecules to mind, and experimental to clinical, are actively engaged in attempts at elucidating the pathophysiology of depression and the mechanisms underlying the efficacy of antidepressant treatments. This first of two special issues of Philosophical Transactions B seeks to provide an overview of current developments in the field, with an emphasis on cellular and molecular mechanisms, and how their unravelling opens new perspectives for future research.
authors: Ottawa Hospital Research Institute (Neuroscience),  University of Ottawa, , Ottawa, Ontario,  Canada , K1H 8M5.
authors: Paul R
authors: PR
authors: Albert
authors: Chawki
authors: C
authors: Benkelfat
authors: Laurent
authors: L
authors: Descarries
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D003863:Depression / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000235:genetics / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D012919:Social Behavior; D009435:Synaptic Transmission
chemical_list: D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors