title: Sarcomatoid carcinoma of the stomach  with osteoclast-like giant cells.
abstract: Carcinomas with osteoclast-like giant cells (OGCs) are a rare type of malignant tumor that is histologically characterized by the presence of multinucleated giant cells that resemble osteoclasts mixed with poorly differentiated adenocarcinoma cells. In this study, we report the clinicopathological and immunohistochemical features of a gastric sarcomatoid carcinoma with OGCs in a 37-year-old male. An abdominal CT scan demonstrated a large mass, measuring 15 cm × 10 cm, in the lesser curvature of the stomach. Microscopic examination revealed that the tumor was composed of sarcomatoid and carcinomatous elements with infiltrating OGCs. Immunohistochemical analysis showed that the sarcomatoid and carcinomatous elements were both variably positive for CK7 and EMA. The sarcomatoid components were also vimentin and SMA positive. This is the first report of a gastric sarcomatoid carcinoma with OGCs. The present tumor has progressed rapidly with extensive perigastric involvement and multiple intrahepatic metastases.
authors: Department of Pathology, the General Hospital, Jinan Military Command, Jinan, China. jnjhbiao@163.com
authors: Hongbiao
authors: H
authors: Jing
authors: Ming
authors: M
authors: Geng
authors: Qingda
authors: Q
authors: Meng
authors: Yanhong
authors: Y
authors: Tai
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D018286:Carcinoma, Giant Cell / Q000737:chemistry / Q000473:pathology*; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D010010:Osteoclasts / Q000473:pathology; D013274:Stomach Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D053552:Keratin-7; D018396:Mucin-1; D014746:Vimentin