title: The A to G polymorphism at -1082 of the interleukin-10 gene is rare             in the Han Chinese population.
abstract: Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.
authors: Department of Cardiology, Fourth People's Hospital of Wuxi and Affiliated Hospital of Jiangnan University, Wuxi 216042, PR China.
authors: Jing
authors: J
authors: Guo
authors: Yong-Hui
authors: YH
authors: He
authors: Feng
authors: F
authors: Chen
authors: Min-Hui
authors: MH
authors: Jiang
authors: Shu-Ping
authors: SP
authors: Gao
authors: Ya-Ming
authors: YM
authors: Su
authors: Gui-Liang
authors: GL
authors: Shi
authors: Xin-Tao
authors: XT
authors: Deng
authors: Jian-Hua
authors: JH
authors: Zhu
authors: Min
authors: M
authors: Pan
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004198:Disease Susceptibility; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D016753:Interleukin-10