title: The effects of vitamin D deficiency on atrial fibrillation.
abstract: BACKGROUND
  Vitamin D deficiency is associated with cardiovascular disease such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For this reason, it could be suggested that there is a relationship between vitamin D deficiency and atrial fibrillation (AF). In our study, we compared 25-hydroxyvitamin D (25-OHD) levels between nonvalvular AF, valvular AF, and control groups in sinus rhythm.
  
  
  METHODS
  A total of 102 patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88; group I) and 96 patients with AF, which is associated with mitral valve disease (mean age 61.51 ± 5; group II) were included in our study. Of all, 100 age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters, 25-OHD and parathormone levels were performed.
  
  
  RESULTS
  Baseline characteristics of the study groups were comparable. Group I patients had a lower vitamin D level than group II and the control group (6.51 ± 4.89, 9.24 ± 7.39, and 11.18 ± 6.98 ng/mL, P < .001, respectively). In groups I and II, the patients' left atrium diameter and systolic pulmonary artery pressure are higher than the control group.
  
  
  CONCLUSIONS
  As a result, our study revealed a relationship between vitamin D deficiency and nonvalvular AF.
authors: 1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.
authors: Mehmet
authors: M
authors: Demir
authors: Umut
authors: U
authors: Uyan
authors: Mehmet
authors: M
authors: Melek
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000000981:diagnostic imaging
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D