title: Cell "vision": complementary factor of protein corona in nanotoxicology.
abstract: Engineered nanoparticles are increasingly being considered for use as biosensors, imaging agents and drug delivery vehicles. Their versatility in design and applications make them an attractive proposition for new biological and biomedical approaches. Despite the remarkable speed of development in nanoscience, relatively little is known about the interaction of nanoscale objects with living systems. In a biological fluid, proteins associate with nanoparticles, and the amount and the presentation of the proteins on their surface could lead to a different in vivo response than an uncoated particle. Here, in addition to protein adsorption, we are going to introduce concept of cell "vision", which would be recognized as another crucial factor that should be considered for the safe design of any type of nanoparticles that will be used in specific biomedical applications. The impact of exactly the same nanoparticles on various cells is significantly different and could not be assumed for other cells; the possible mechanisms that justify this cellular response relate to the numerous detoxification strategies that any particular cell can utilize in response to nanoparticles. The uptake and defence mechanism could be considerably different according to the cell type. Thus, what the cell "sees", when it is faced with nanoparticles, is most likely dependent on the cell type.
authors: Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mahmoudi@biospion.com
authors: Morteza
authors: M
authors: Mahmoudi
authors: Seyyed N
authors: SN
authors: Saeedi-Eslami
authors: Mohammad A
authors: MA
authors: Shokrgozar
authors: Kayhan
authors: K
authors: Azadmanesh
authors: Maryam
authors: M
authors: Hassanlou
authors: Hamid R
authors: HR
authors: Kalhor
authors: Carmen
authors: C
authors: Burtea
authors: Barbara
authors: B
authors: Rothen-Rutishauser
authors: Sophie
authors: S
authors: Laurent
authors: Sara
authors: S
authors: Sheibani
authors: Hojatollah
authors: H
authors: Vali
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D057809:HEK293 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D019169:Jurkat Cells; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
chemical_list: D011506:Proteins; D017382:Reactive Oxygen Species