title: Primary cutaneous diffuse large B-cell lymphoma, leg type: diagnostic considerations.
abstract: BACKGROUND
  Primary cutaneous diffuse large B-cell lymphoma, leg type, may show features that overlap with other lymphomas. However, timely recognition of this entity can have important clinical and therapeutic implications.
  
  
  OBJECTIVE
  To review the clinical, morphologic, and immunophenotypic characteristics of primary cutaneous diffuse large B-cell lymphoma, leg type, and juxtapose these features with other diagnostic considerations. In particular, other variants of primary cutaneous diffuse large B-cell lymphoma, as well as primary cutaneous follicle center lymphoma, will be reviewed. Additionally, systemic/extracutaneous lymphomas will be discussed, including diffuse large B-cell lymphoma, not otherwise specified, Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly, and lymphomatoid granulomatosis.
  
  
  METHODS
  Relevant literature will be reviewed and key differentiating findings will be highlighted.
  
  
  CONCLUSIONS
  Although primary cutaneous diffuse large B-cell lymphoma, leg type, may show aspects that overlap with other lymphomas, it can be distinguished from other entities in the differential diagnosis.
authors: Department of Pathology, Dermatopathology, University of Michigan, Ann Arbor, MI 48109-5602, USA. ahristov@med.umich.edu
authors: Alexandra C
authors: AC
authors: Hristov
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007866:Leg; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000821:virology; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000821:virology