title: Associations between gastric sensorimotor function, depression, somatization, and symptom-based subgroups in functional gastroduodenal disorders: are all symptoms equal?
abstract: BACKGROUND
  Previous work indicated that psychosocial factors (depression and somatization) are more strongly associated with symptom severity and weight loss in functional dyspepsia (FD) than gastric sensorimotor function. However, there is conflicting evidence regarding the association of these etiopathogenetic factors with Rome III symptom-based subgroups in FD [epigastric pain syndrome (EPS), postprandial distress syndrome (PDS)]. We aimed to test whether gastric sensitivity and emptying, depression, and somatization are differentially associated with empirically derived functional gastroduodenal disorders (FGD) symptom factors in one comprehensive model.
  
  
  METHODS
  In 259 tertiary care FD patients, we studied gastric sensorimotor function with barostat and gastric emptying breath test. Depression, somatization, and FGD symptoms were measured using self-report questionnaires. Confirmatory factor analysis (CFA) on 7 FGD symptoms was used to determine the fit of a latent variable structure based on Rome III symptom-based subgroups. Structural equation modeling (SEM) was used to test the putative relationships of the symptom factors with gastric sensorimotor function, depression, and somatization.
  
  
  RESULTS
  The results of the CFA show a good fit [C(min) /DF = 1.54, CFI(comparative fit index) = 0.97] for the three-factor solution based on Rome III subgroups. The SEM also fitted the data well (C(min) /DF = 1.24, CFI = 0.98) and demonstrated that gastric sensitivity and depression are associated with PDS and nausea and vomiting. Gastric emptying is uniquely associated with EPS and somatization is strongly associated with all three symptom factors.
  
  
  CONCLUSIONS
  Confirmatory factor analysis confirms the existence of three FGD symptom factors, corresponding to Rome III symptom-based subgroups. The SEM results suggest that different psychobiological mechanisms may play a role in these subgroups.
authors: Child and Adolescent Psychiatry, University Psychiatric Centre, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.
authors: N
authors: N
authors: Clauwaert
authors: M P
authors: MP
authors: Jones
authors: L
authors: L
authors: Holvoet
authors: J
authors: J
authors: Vandenberghe
authors: R
authors: R
authors: Vos
authors: J
authors: J
authors: Tack
authors: L
authors: L
authors: Van Oudenhove
mesh_terms: D000328:Adult; D001944:Breath Tests; D003863:Depression / Q000150:complications* / Q000523:psychology; D004415:Dyspepsia; D005163:Factor Analysis, Statistical; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005767:Gastrointestinal Diseases / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D008297:Male; D008365:Manometry; D017288:Pain Threshold; D013001:Somatoform Disorders / Q000150:complications* / Q000523:psychology