title: Photocrosslinkable gellan gum film as an anti-adhesion barrier.
abstract: The purpose of this study was to develop a gellan gum-based film which could be photocrosslinked for medical applications. Gellan gum was grafted with cinnamate to yield the photo crosslinkable polymer (gellan gum-cin). This material had 14.7% of its D-galacturonic residues reacted with cinnamate groups and displayed maximum absorption at 254 nm. Investigation of the photochemical properties showed that the crosslinking efficiency was 82% after 16 min of UV irradiation. The anti-adhesion films prepared from gellan gum-cin polymers exhibited high gel contents (88 ± 2%) and suitable mechanical properties. When implanted into rats, the gellan gum-cin film exhibited the most promising anti-adhesion potential in 2 out of 10 rats without forming any tissue adhesion. Furthermore, the gellan gum-cin film could effectively inhibit inflammation in rats based on the results of fluid leukocyte analyses. The gellan gum-cin film thus has potential in clinical applications.
authors: Department of Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan. d880430@csmu.edu.tw
authors: Ming-Wei
authors: MW
authors: Lee
authors: Hui-Fang
authors: HF
authors: Tsai
authors: Shu-Min
authors: SM
authors: Wen
authors: Chia-Hui
authors: CH
authors: Huang
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000494:pharmacology; D005782:Gels; D015552:Injections, Intralesional; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D055668:Photochemical Processes; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D003432:Cross-Linking Reagents; D005782:Gels; D011108:Polymers; D011135:Polysaccharides, Bacterial; C048288:gellan gum