title: Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.
abstract: XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 selected control subjects were negative. CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences. These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested.
authors: Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors: Stefania
authors: S
authors: Paolucci
authors: Antonio
authors: A
authors: Piralla
authors: Cinzia
authors: C
authors: Zanello
authors: Lorenzo
authors: L
authors: Minoli
authors: Fausto
authors: F
authors: Baldanti
mesh_terms: D000818:Animals; D001483:Base Sequence; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D015673:Fatigue Syndrome, Chronic / Q000235:genetics / Q000821:virology*; D005814:Genes, Viral; D015750:Genes, gag; D006678:HIV / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D009052:Leukemia Virus, Murine / Q000145:classification / Q000235:genetics; D051379:Mice; D012192:Retroviridae Infections / Q000175:diagnosis* / Q000821:virology; D016415:Sequence Alignment; D058008:Xenotropic murine leukemia virus-related virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004272:DNA, Mitochondrial; D004279:DNA, Viral