title: Solubilisation capacity of Brij surfactants.
abstract: The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities of other poly(ethylene oxide)-based copolymers. UV/Vis and (1)H NMR spectroscopies were used to quantify the enhancement of solubility of griseofulvin in 1 wt% aqueous micellar solutions of Brij 78 (C(18)H(37)E(20)), Brij 98 (C(18)H(35)E(20)) and Brij 700 (C(18)H(37)E(100)) (where E represents the OCH(2)CH(2) unit of the poly(ethylene oxide) chain) at 25, 37 and 40 °C. Solubilisation capacities (S(cp) expressed as mg griseofulvin per g Brij) were similar for Brij 78 and 98 (range 6-11 mg g(-1)) but lower for Brij 700 (3-4 mg g(-1)) as would be expected for the surfactant with the higher ethylene oxide content. The drug loading capacity of micelles of Brij 78 was higher than many di- and triblock copolymers with hydrophilic E-blocks specifically designed for enhancement of drug solubility.
authors: Departamento de Química Orgânica e Inorgânica da UFC, CX 12200 Fortaleza, Ceará, Brazil.
authors: Maria E N P
authors: ME
authors: Ribeiro
authors: Carolina L
authors: CL
authors: de Moura
authors: Mariano G S
authors: MG
authors: Vieira
authors: Nilce V
authors: NV
authors: Gramosa
authors: Chiraphon
authors: C
authors: Chaibundit
authors: Marcos C
authors: MC
authors: de Mattos
authors: David
authors: D
authors: Attwood
authors: Stephen G
authors: SG
authors: Yeates
authors: S Keith
authors: SK
authors: Nixon
authors: Nágila M P S
authors: NM
authors: Ricardo
mesh_terms: D006118:Griseofulvin / Q000737:chemistry*; D008823:Micelles; D010938:Plant Oils / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: C577209:Brij 700; D008823:Micelles; D010938:Plant Oils; D013501:Surface-Active Agents; D006118:Griseofulvin; D011092:Polyethylene Glycols; C033084:polyethylene glycol oleyl ether; C043444:octadecyl polyoxyethylene ether