title: Simplexins P-S, eunicellin-based diterpenes from the soft coral Klyxum simplex.
abstract: Four new eunicellin-based diterpenes, simplexins P-S (1-4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3-5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan.
authors: Shwu-Li
authors: SL
authors: Wu
authors: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Jui-Hsin
authors: JH
authors: Su
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chiung-Yao
authors: CY
authors: Huang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chi-Jen
authors: CJ
authors: Tai
authors: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors: Ping-Jyun
authors: 0000-0002-6644-9236
authors: PJ
authors: Sung
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chih-Chung
authors: 0000-0002-3552-3958
authors: CC
authors: Liaw
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Jyh-Horng
authors: JH
authors: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D013729:Terpenes; C476503:eunicellin; C011110:simplexin