title: Chiral phosphine-catalyzed asymmetric allylic alkylation of 3-substituted benzofuran-2(3H)-ones or oxindoles with Morita-Baylis-Hillman carbonates.
abstract: An efficient chiral phosphine-catalyzed asymmetric substitution reaction of MBH carbonates with 3-substituted benzofuran-2(3H)-ones or 3-substituted oxindoles has been described in this context, giving the corresponding allylic alkylation products bearing adjacent quaternary and tertiary stereogenic centers in high yields, moderate diastereoselectivities and high enantioselectivities under mild conditions.
authors: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, China.
authors: De
authors: D
authors: Wang
authors: Yuan-Liang
authors: YL
authors: Yang
authors: Jia-Jun
authors: JJ
authors: Jiang
authors: Min
authors: M
authors: Shi
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D001572:Benzofurans; D002254:Carbonates; D007211:Indoles; D000078183:Oxindoles; D010720:Phosphines; C022960:2-oxindole; C044646:phosphine