title: Influence of arterial hypertension on colonic healing in rats.
abstract: OBJECTIVE
  Evaluation of colonic healing in spontaneously hypertensive rats.
  
  
  METHODS
  Fifty male, young and inbred rats were used. Twenty-five Wistar Kyoto rats (WKY) as control and twenty-five spontaneously hypertensive rats (SHR) as an experimental group. Colotomy and bowel suture at 2.5 cm from the peritoneal reflection were performed. All animals were allocated randomly into sub-groups for review at the third, seventh and fourteenth days after surgery. We evaluated the concentration of angiotensin II, the burst pressure, epithelialization, the organization of the tunics of the bowel wall, inflammatory response and collagen deposition.
  
  
  RESULTS
  The burst pressure, epithelialization, organization of the tunics and collagen deposition was not significant between groups. The inflammatory reaction was more intense in the control group on the third postoperative day (p=0.023) as the experimental group on the remaining time.
  
  
  CONCLUSIONS
  Systemic arterial hypertension in rats did not influence significantly the healing process of colonic anastomoses.
authors: Department of Surgery, PUCPR, Parana, Brazil. gilbertoortolan@gmail.com
authors: Gilberto Luiz
authors: GL
authors: Ortolan
authors: Maria de Lourdes Pessole
authors: Mde L
authors: Biondo-Simões
authors: Giovani Marino
authors: GM
authors: Fávero
authors: Daniel
authors: D
authors: Fernandes
authors: Mário Rodrigues
authors: MR
authors: Montemór Netto
authors: Luiz Renato
authors: LR
authors: Olchanheski
mesh_terms: D000714:Anastomosis, Surgical; D000804:Angiotensin II / Q000032:analysis; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013529:Surgical Wound Dehiscence / Q000503:physiopathology; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*
chemical_list: D000804:Angiotensin II; D003094:Collagen