title: [The distribution of iodine-125 labeled alpha-fetoprotein in the animal organism and its accumulation in the tumor].
abstract: The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of alpha-fetoprotein in different tissues and organs of animals was observed mainly 5 hours after injection. Then the protein was gradually eliminated from the body. In the liver, intestine and blood of intact animals 125I-alpha-fetoprotein persists for at least three days. Accumulation of alpha-fetoprotein in various tissues and organs may determine the different biological effects of this protein. In the mice with transplanted lymphatic leukemia cells P388 the high level of alpha-fetoprotein accumulation was detected in the tumor tissue, reaching 6% of the injected amount per 1 g of tissue. This allows considering the radionuclide-labeled alpha-fetoprotein as a promising medical radionuclide marker for the radiological detection of malignant tumors.
authors: S E
authors: SE
authors: Severin
authors: V N
authors: VN
authors: Kulakov
authors: E Iu
authors: EIu
authors: Moskaleva
authors: E S
authors: ES
authors: Severin
authors: I I
authors: II
authors: Slobodianik
authors: T P
authors: TP
authors: Klimova
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays; D000509:alpha-Fetoproteins / Q000493:pharmacokinetics*
chemical_list: C097353:AFP protein, human; D007457:Iodine Radioisotopes; D000509:alpha-Fetoproteins