title: Toward cardiovascular interventions guided by magnetic particle imaging: first instrument characterization.
abstract: Magnetic particle imaging has emerged as a new technique for the visualization and quantification of superparamagnetic iron oxide nanoparticles. It seems to be a very promising application for cardiovascular interventional radiology. A prerequisite for interventions is the artifact-free visualization of the required instruments and implants. Various commercially available catheters, guide wires, and a catheter experimentally coated with superparamagnetic iron oxide nanoparticles were tested regarding their signal characteristics using magnetic particle spectroscopy to evaluate their performance in magnetic particle imaging. The results indicate that signal-generating and non-signal-generating instruments can be distinguished. Furthermore, coating or loading non-signal-generating instruments with superparamagnetic iron oxide nanoparticles seems to be a promising approach, but optimized nanoparticles need yet to be developed.
authors: Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. haegele@radiologie.uni-luebeck.de
authors: Julian
authors: J
authors: Haegele
authors: Sven
authors: S
authors: Biederer
authors: Hanne
authors: H
authors: Wojtczyk
authors: Matthias
authors: M
authors: Gräser
authors: Tobias
authors: T
authors: Knopp
authors: Thorsten M
authors: TM
authors: Buzug
authors: Jörg
authors: J
authors: Barkhausen
authors: Florian M
authors: FM
authors: Vogt
mesh_terms: D016477:Artifacts; D062906:Cardiac Catheters; D003287:Contrast Media; D003911:Dextrans; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation*; D058185:Magnetite Nanoparticles; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10