title: Synthesis and sensory evaluation of ent-kaurane diterpene glycosides.
abstract: Catalytic hydrogenation of the three ent-kaurane diterpene glycosides isolated from Stevia rebaudiana, namely rubusoside, stevioside, and rebaudioside-A has been carried out using Pd(OH)₂ and their corresponding dihydro derivatives have been isolated as the products. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on the basis of 1D and 2D NMR spectral data and chemical studies. Also, we report herewith the sensory evaluation of all the reduced compounds against their corresponding original steviol glycosides and sucrose for the sweetness property of these molecules.
authors: Organic Chemistry Department, Global Research and Development, The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, GA 30313, USA.
authors: Indra
authors: I
authors: Prakash
authors: Mary
authors: M
authors: Campbell
authors: Rafael Ignacio
authors: RI
authors: San Miguel
authors: Venkata Sai Prakash
authors: VS
authors: Chaturvedula
mesh_terms: D002384:Catalysis; D045786:Diterpenes, Kaurane / Q000138:chemical synthesis* / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006865:Hydrogenation; D006868:Hydrolysis; D006878:Hydroxides / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D011096:Polygalacturonase / Q000737:chemistry; D013549:Sweetening Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013649:Taste
chemical_list: D045786:Diterpenes, Kaurane; D005656:Fungal Proteins; D005960:Glucosides; D006027:Glycosides; D006878:Hydroxides; D013549:Sweetening Agents; C012043:stevioside; D010165:Palladium; C025474:rebaudioside A; D011096:Polygalacturonase; C056177:rubusoside