title: Effect of botulinum toxin a injection into the salivary glands for sialorrhea in children with neurologic disorders.
abstract: OBJECTIVE
  To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires.
  
  
  METHODS
  A total of 17 patients (age 7.6±4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance.
  
  
  RESULTS
  DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.
  
  
  CONCLUSIONS
  Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.
authors: Department of Rehabilitation Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 700-712, Korea.
authors: In Seuk
authors: IS
authors: Jeung
authors: Soyoung
authors: S
authors: Lee
authors: Heung Sik
authors: HS
authors: Kim
authors: Chang Ki
authors: CK
authors: Yeo