title: Hollow copper sulfide nanoparticle-mediated transdermal drug delivery.
abstract: A photothermal ablation-enhanced transdermal drug delivery methodology is developed based on hollow copper sulfide nanoparticles (HCuSNPs) with intense photothermal coupling effects. Application of nanosecond-pulsed near-infrared laser allows rapid heating of the nanoparticles and instantaneous heat conduction. This provides very short periods of time but extremely high temperatures in local regions, with focused thermal ablation of the stratum corneum. The depth of skin perforations can be controlled by adjusting the laser power. Skin disruption by HCuSNP-mediated photothermal ablation significantly increases the permeability of human growth hormone. This technique offers compelling opportunities for macromolecular drug and vaccine delivery.
authors: Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA.
authors: Samy
authors: S
authors: Ramadan
authors: Liangran
authors: L
authors: Guo
authors: Yajuan
authors: Y
authors: Li
authors: Bingfang
authors: B
authors: Yan
authors: Wei
authors: W
authors: Lu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003300:Copper / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D053685:Laser Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D003300:Copper