title: Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus.
abstract: The study objective was clinical assessment of the efficacy of photodynamic therapy (PDT) in the treatment of oral lichen planus (OLP). There were 23 patients aged 31-82 included in the study with oral lichen planus diagnosed clinically and histopathologically. In all patients photodynamic therapy was performed with the use of chlorin e6 (Photolon(®)), containing 20 % chlorin e6 and 10 % dimethyl sulfoxide as a photosensitizer. PDT was performed using a semiconductor laser, with power up to 300 mW and a wavelength of 660 nm. A series of illumination sessions was conducted with the use of superficial light energy density of 90 J/cm(2). Changes of lesion size were monitored at one, two, five, and ten PDT appointments from the series of ten according to the authors' own method. The sizes of clinical OLP lesions exposed to PDT were reduced significantly (on average by 55 %). The best effects were observed for the lesions on the lining mucosa (57.6 %). The therapy was statistically significantly less effective when masticatory mucosa was affected (reduction, 30.0 %). Due to substantial efficacy and noninvasiveness, PDT can be useful in the treatment of OLP lesions.
authors: Department of Periodontal and Oral Mucosa Diseases, Medical University of Białystok, ul. Waszyngtona 13, 15-269, Białystok, Poland.
authors: Stefan
authors: S
authors: Sobaniec
authors: Piotr
authors: P
authors: Bernaczyk
authors: Jan
authors: J
authors: Pietruski
authors: Magdalena
authors: M
authors: Cholewa
authors: Anna
authors: A
authors: Skurska
authors: Ewa
authors: E
authors: Dolińska
authors: Ewa
authors: E
authors: Duraj
authors: Grażyna
authors: G
authors: Tokajuk
authors: Agnieszka
authors: A
authors: Paniczko
authors: Ewa
authors: E
authors: Olszewska
authors: Małgorzata
authors: M
authors: Pietruska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D004121:Dimethyl Sulfoxide