title: Growth curves of Egyptian patients with Turner syndrome.
abstract: This study analyzes the body anthropometric measurements in females with Turner syndrome (TS) not treated with recombinant human growth hormone. Height, weight, head circumference, and body mass index (BMI) data were collected from 93 patients. Their ages ranged from 6 months to 24 years (mean 10 ± 4.3 years). Chromosomal analysis revealed: 55 patients with 45,X and 38 patients with mosaic karyotypes. Patients were divided into yearly age groups. Standard growth curves were constructed for these Egyptian Turner syndrome (TS) patients. Mean and standard deviations were estimated across the age groups. When comparing the mean heights of patients to the Egyptian standards, short stature (≤2 SD) was found in 96.8% of patients older than 6 years. Patients' mean weight and BMI were higher than controls. The mean height of the studied Egyptian patients was slightly lower than that of females with TS in UK and European patients. Therefore, local reference values are more appropriate than International standards. The charts presented here can be used to optimize routine healthcare for Egyptian TS patients. The use of growth charts specific for Egyptian TS patients can help to discover early physical developmental delay and suggests the necessity of looking for concomitant diseases affecting growth.
authors: Clinical Genetics Department, National Research Centre, Cairo, Egypt. halabassyouni@yahoo.com
authors: Hala T
authors: HT
authors: El-Bassyouni
authors: Hanan H
authors: HH
authors: Afifi
authors: Mona S
authors: MS
authors: Aglan
authors: Wael M
authors: WM
authors: Mahmoud
authors: Moushira E
authors: ME
authors: Zaki
mesh_terms: D000293:Adolescent; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D004534:Egypt; D005260:Female; D057238:Growth Charts; D006801:Humans; D007223:Infant; D059785:Karyotype; D014424:Turner Syndrome / Q000175:diagnosis* / Q000235:genetics; D055815:Young Adult