title: An agar diffusion study comparing the antimicrobial activity of Nanoseal with some other endodontic sealers.
abstract: The aim of this study was to evaluate the antimicrobial activity of a new experimental nano-hydroxyapatite epoxy resin-based sealer (Nanoseal) with several other commercially available sealers; AH26, Tubliseal, Sealapex and Roekoseal against Enterococcus faecalis, Pseudomonas aeruginosa, Streptococcus mutans, Streptococcus sobrinus and Escherichia coli for up to 7 days. Agar diffusion was used in this study. Fifty Muller-Hinton agar plates were prepared and divided into five experimental groups (n = 10), for each micro-organism. Another 10 agar plates were used as positive and negative controls. Endodontic sealers were tested against each micro-organism. Inhibition zones produced were recorded. The results of this study showed that all test materials exhibited inhibition zones towards the tested micro-organisms for 7 days except for Roekoseal, which showed no inhibition zones. Nanoseal and AH26 exhibited similar zones of inhibition. Significant difference was found between Nanoseal and the other tested sealers (P < 0.001).
authors: Restorative Unit School of Dental Science, Science University of Malaysia, Kelantan, Malaysia.
authors: Ali Burak
authors: AB
authors: Aal-Saraj
authors: Zaihan
authors: Z
authors: Ariffin
authors: Sam'an Malik
authors: SM
authors: Masudi
mesh_terms: D000362:Agar; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D052978:Disk Diffusion Antimicrobial Tests / Q000379:methods; D004853:Epoxy Resins / Q000494:pharmacology*; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D018709:Statistics, Nonparametric
chemical_list: D000890:Anti-Infective Agents; D004853:Epoxy Resins; D012387:Root Canal Filling Materials; D000362:Agar