title: Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment.
abstract: MicroRNAs (miRNAs) act to fine-tune cellular responses in a variety of biological circumstances such as development, organogenesis, and homeostasis. The dysregulation of miRNA expression accelerates disease progression, including metabolic disease, immunological disease and cancer, through the gene network disorder. Therefore, understanding the miRNA maturation process may unravel the mechanisms of cancer malignancy; however, the life of miRNA has not been clarified. In this article, we summarize the recent findings regarding the novel forms of miRNA, especially secretory miRNAs, focusing on exosomal miRNAs. Recent research has revealed that exosomal miRNAs affect many aspects of physiological and pathological conditions, and may be useful as novel therapy. Here, we propose a method for the delivery of tumor-suppressive miRNAs to desired sites using exosomes, and we named this method "exocure".
authors: Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Tokyo 104-0045, Japan. nkosaka@ncc.go.jp
authors: Nobuyoshi
authors: N
authors: Kosaka
authors: Fumitaka
authors: F
authors: Takeshita
authors: Yusuke
authors: Y
authors: Yoshioka
authors: Keitaro
authors: K
authors: Hagiwara
authors: Takeshi
authors: T
authors: Katsuda
authors: Makiko
authors: M
authors: Ono
authors: Takahiro
authors: T
authors: Ochiya
mesh_terms: D000818:Animals; D018450:Disease Progression; D055354:Exosomes / Q000378:metabolism*; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000008:administration & dosage / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage
chemical_list: D035683:MicroRNAs; D034741:RNA, Small Interfering