title: Improving bioavailability of silybin by inclusion into SBA-15 mesoporous silica materials.
abstract: Mesoporous silica SBA-15 (SC) and template occluded SBA-15 (SP) were used to increase the bioavailability of silybin, an extremely poorly water soluble drug. Silybin was introduced into SC and SP by assembling or self-assembling methods. The results of X-ray powder diffraction, differential scanning calorimetry (DSC) and N2 adsorption-desorption experiment indicated that amorphous silybin was successfully introduced into the mesopores in both SC and SP samples. The transmission electron micrograph (TEM) images revealed that the structure of the mesoporous materials was not destroyed after the drug loading. Results of dissolution rate tests and animal experiments showed that both SC and SP can significantly improve the bioavailability of silybin, SP was thus preferred because the template needs not to be removed by calcination or extraction.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.
authors.forename: Tingming
authors.initials: T
authors.lastname: Fu
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.forename: Liwei
authors.initials: L
authors.lastname: Guo
authors.forename: Lianjun
authors.initials: L
authors.lastname: Zhang
authors.forename: Xueping
authors.initials: X
authors.lastname: Cai
authors.forename: Huaxu
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D011208:Powders / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000737:chemistry*; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000494:pharmacology; D012995:Solubility; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D011208:Powders; C509969:SBA-15; D012838:Silymarin; D000077385:Silybin; D012822:Silicon Dioxide; D009584:Nitrogen