title: Synergistic targeting of cancer and associated angiogenesis using triple-targeted dual-drug silica nanoformulations for theragnostics.
abstract: The targeting and therapeutic efficacy of dye- and dual-drug-loaded silica nanoparticles, functionalized with triple targeting ligands specific towards cancer and neoangiogenesis simultaneously, are discussed. This synergized, high-precision, multitarget concept culminates in an elevated uptake of nanoparticles by cancer and angiogenic cells with amplified proficiency, thereby imparting superior therapeutic efficacy against breast cancer cells and completely disabling the migration and angiogenic sprouting ability of activated endothelial cells. The exceptional multimodal efficiency achieved by this single therapeutic nanoformulation holds promise for the synergistic targeting and treatment of the yet elusive cancer and its related angiogenesis in a single, lethal shot.
authors.affiliation: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama 350-8585, Japan.
authors.forename: Srivani
authors.initials: S
authors.lastname: Veeranarayanan
authors.forename: Aby Cheruvathoor
authors.initials: AC
authors.lastname: Poulose
authors.forename: M Sheikh
authors.initials: MS
authors.lastname: Mohamed
authors.forename: Saino Hanna
authors.initials: SH
authors.lastname: Varghese
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Toru
authors.initials: T
authors.lastname: Maekawa
authors.forename: D Sakthi
authors.initials: DS
authors.lastname: Kumar
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry; D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D016503:Drug Delivery Systems; D004357:Drug Synergism; D042783:Endothelial Cells / Q000187:drug effects; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008024:Ligands; D008055:Lipids / Q000737:chemistry; D061986:MCF-7 Cells; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic; D011092:Polyethylene Glycols / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D002593:Cetrimonium Compounds; D005456:Fluorescent Dyes; D008024:Ligands; D008055:Lipids; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D000077286:Cetrimonium