title: A life-threatening flecainide overdose treated with intravenous fat emulsion.
abstract: Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.
authors.affiliation: Department of Emergency Medicine, Regions Hospital, St. Paul, MN 55101, USA. heatherellsworth9@gmail.com
authors.forename: Heather
authors.initials: H
authors.lastname: Ellsworth
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Stellpflug
authors.forename: Jon B
authors.initials: JB
authors.lastname: Cole
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Dolan
authors.forename: Carson R
authors.initials: CR
authors.lastname: Harris
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy*; D004638:Emergency Treatment; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D005424:Flecainide / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000889:Anti-Arrhythmia Agents; D005217:Fat Emulsions, Intravenous; D005424:Flecainide