title: Targeting tyrosine kinases in cancer: the converging roles of cytopathology and molecular pathology in the era of genomic medicine.
abstract: Because of knowledge gained in the field of cancer biology, clinicians are currently witnessing an explosion of molecular tests as companion diagnostics to targeted therapies against growth factor receptors and their signaling pathways. Such tests are being applied increasingly to cytology specimens as essential components of genomic medicine, because less invasive diagnostic procedures are becoming the norm. The objective of this review was to present an overview of the current and future role of cytopathology in molecular diagnostics, including the adequacy of cytology specimens for such studies. The authors also discuss the critical methodologic aspects of the molecular assays used for the selection of tyrosine kinase treatment for oncology patients.
authors.affiliation: Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298, USA. cdumur@mcvh-vcu.edu
authors.forename: Catherine I
authors.initials: CI
authors.lastname: Dumur
authors.forename: Michael O
authors.initials: MO
authors.lastname: Idowu
authors.forename: Celeste N
authors.initials: CN
authors.lastname: Powers
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005544:Forecasting; D023281:Genomics / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends*; D009363:Neoplasm Proteins / Q000187:drug effects / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D057089:Pathology, Molecular / Q000379:methods / Q000639:trends; D010597:Pharmacogenetics / Q000639:trends; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000627:therapeutic use; D014481:United States
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases