title: Cervical cord FMRI abnormalities differ between the progressive forms of multiple sclerosis.
abstract: OBJECTIVE
  Aim of this study was to compare tactile-associated cervical cord fMRI activity between primary progressive (PP) and secondary progressive (SP) MS patients and to investigate whether cord recruitment was associated with structural brain and cord damage.
  
  
  METHODS
  Cervical cord fMRI during a tactile stimulation of the right hand was acquired from 17 healthy controls, 18 SPMS patients, and 16 PPMS patients. Average fMRI activity and its topographical distribution in cord sectors (left vs. right, posterior vs. anterior) were assessed. Correlations between cord recruitment and structural cord and brain MRI were estimated.
  
  
  RESULTS
  Progressive MS patients showed an increased cord recruitment compared with controls (P = 0.003). Despite a similar structural cord damage, cord activity was increased in SPMS compared to PPMS patients (P = 0.05). Regional analysis showed a non-lateralized pattern of cord recruitment in MS patients. Compared to PPMS, SPMS patients had grey matter (GM) atrophy in several cortical and subcortical regions. In SPMS patients, atrophy of the left postcentral gyrus was correlated with cord activity (r = -0.48, P = 0.04).
  
  
  CONCLUSIONS
  Patients with progressive MS had an over-recruitment of the cervical cord, which was more pronounced in SPMS than PPMS, despite similar cord structural damage. The alteration of the complex modulation of spinal cord interneurons possibly due to a loss of supratentorial inhibition secondary to brain injury might contribute to explain the observed functional cord abnormalities.
authors.affiliation: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Valsasina
authors.forename: Maria A
authors.initials: MA
authors.lastname: Rocca
authors.forename: Martina
authors.initials: M
authors.lastname: Absinta
authors.forename: Federica
authors.initials: F
authors.lastname: Agosta
authors.forename: Domenico
authors.initials: D
authors.lastname: Caputo
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Comi
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001284:Atrophy; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D002574:Cervical Vertebrae / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000145:classification / Q000473:pathology*; D011999:Recruitment, Neurophysiological / Q000502:physiology; D013116:Spinal Cord / Q000473:pathology*