title: Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS.
abstract: Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.
authors.affiliation: Infectious Diseases Department, Montpellier University Hospital, Montpellier, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Brunel
authors.forename: Jacques
authors.initials: J
authors.lastname: Reynes
authors.forename: Edouard
authors.initials: E
authors.lastname: Tuaillon
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Rubbo
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Brigitte
authors.initials: B
authors.lastname: Montes
authors.forename: Vincent
authors.initials: V
authors.lastname: Le Moing
authors.forename: Alain
authors.initials: A
authors.lastname: Makinson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000188:drug therapy* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000276:immunology; D008875:Middle Aged; D012008:Recurrence; D013256:Steroids / Q000627:therapeutic use; D013792:Thalidomide / Q000494:pharmacology*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D013792:Thalidomide