title: Monitoring the on-line titration of enantiomeric omeprazole employing continuous-flow capillary microcoil 1H NMR spectroscopy.
abstract: The titration of the (S)-enantiomer of omeprazole with the (R)-enantiomer in chloroform-d(1) is monitored by continuous-flow capillary microcoil (1)H NMR spectroscopy employing a microcoil with a detection volume of 1.5 µl. The observed changes of the (1)H NMR chemical shifts indicate the formation of a heterochiral (R,S) dimer of omeprazole via its sulfinyl group and the NH group of the benzimidazole ring.
authors.affiliation: Institute of Organic Chemistry, University of Tübingen, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Hentschel
authors.forename: Karsten
authors.initials: K
authors.lastname: Holtin
authors.forename: Lisa
authors.initials: L
authors.lastname: Steinhauser
authors.forename: Klaus
authors.initials: K
authors.lastname: Albert
mesh_terms: D000897:Anti-Ulcer Agents / Q000737:chemistry*; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D009853:Omeprazole / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole