title: Update on the management of disorders of sex development.
abstract: A number of factors have contributed to a sharp increase in the number of publications related to disorders of sex development (DSD) in the past 5 years, namely: the establishment of a consensus in 2006 about nomenclature, investigations and the need to treat these patients in a multidisciplinary setting; increase of the knowledge base about genetic mechanisms of normal and abnormal sex development; critical appraisal about the timing and nature of genital surgery in patients with DSD. Herein, the authors present a comprehensive review with up-to-date data about the approach to the newborn with ambiguous genitalia as well as the diagnosis and management of the most common DSD.
authors.affiliation: Division of Urology, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Rodrigo L P
authors.initials: RL
authors.lastname: Romao
authors.forename: Joao L Pippi
authors.initials: JL
authors.lastname: Salle
authors.forename: Diane K
authors.initials: DK
authors.lastname: Wherrett
mesh_terms: D012734:Disorders of Sex Development / Q000145:classification / Q000175:diagnosis / Q000523:psychology / Q000601:surgery*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010808:Physical Examination; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012732:Sex Determination Analysis; D013520:Urologic Surgical Procedures