title: Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([18F]-FMISO).
abstract: We report an automated synthesis of [(18)F]-FMISO utilizing a prototype microfluidic radiochemistry module. The instrument allows for production of the tracer with 58%±2% (11 runs) decay corrected yield. Total time of production, including synthesis and purification averages 60 min. Use of the microfluidic platform results in a specific activity of 138.6 GBq/μ mol, which is higher than previously reported for conventional reactors.
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. dyokell@partners.org
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Yokell
authors.forename: Alicia K
authors.initials: AK
authors.lastname: Leece
authors.forename: Artem
authors.initials: A
authors.lastname: Lebedev
authors.forename: Reza
authors.initials: R
authors.lastname: Miraghaie
authors.forename: Carroll E
authors.initials: CE
authors.lastname: Ball
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhang
authors.forename: Hartmuth
authors.initials: H
authors.lastname: Kolb
authors.forename: Arkadij
authors.initials: A
authors.lastname: Elizarov
authors.forename: Umar
authors.initials: U
authors.lastname: Mahmood
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry*; D044085:Microfluidics; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; C031843:fluoromisonidazole; D008920:Misonidazole; D010100:Oxygen