title: What is known on angiogenesis-related rare diseases? A systematic review of literature.
abstract: Angiogenesis, the formation of new vessels from pre-existing ones, is essential during ontogenetic development and is related to many important physio-pathological processes in the adult. In fact, a persistent and deregulated angiogenesis is a required event for many diseases and pathological situations, including cancer progression and metastasis. Some rare diseases are also angiogenesis-related pathologies. However, there is a lack of an exhaustive review on the topic. The main purpose of this work is to carry out a systematic review of literature to determine what (and how much) scientific information concerning angiogenesis-related rare diseases can be extracted from available sources. After exhaustive searches in bibliographic databases, preselected data were filtered by selecting only those articles on rare diseases with an Orpha number hosted in the Orphanet web. The selected bibliographic references were further curated manually. With the 187 selected references, a critical reading and analysis was carried out allowing for an identification and classification of angiogenesis-related rare diseases, the involved genes and the drugs available for their treatment, all on the basis of the information available in Orphanet database.
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Rodríguez-Caso
authors.forename: Armando
authors.initials: A
authors.lastname: Reyes-Palomares
authors.forename: Francisca
authors.initials: F
authors.lastname: Sánchez-Jiménez
authors.forename: Ana R
authors.initials: AR
authors.lastname: Quesada
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Medina
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D035583:Rare Diseases / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D020533:Angiogenesis Inhibitors