title: Dehydroepiandrosterone treatment effects on weight, bone density, bone metabolism and mood in women suffering from anorexia nervosa-a pilot study.
abstract: We investigated the effects of the administration of dehydroepiandrosterone (DHEA) on weight, bone metabolism, bone density and clinical mood symptoms in outpatient Anorexia Nervosa (AN) patients. AN patients (n=26) were double-blindly randomized to receive DHEA (100mg) or placebo for 6 months. Outcome measures were bone mineral density (BMD) and bone mineral content (BMC) measured by dual energy X-ray absorptiometry (DXA) and metabolism indexes, steroid hormones, and mood and eating disorder symptoms measured at baseline and at the 3 and 6 months follow-up visits. Mood and eating disorder symptoms were assessed monthly by the Beck Depression Inventory, Eating Disorder Inventory and Clinical Global Improvement Scales. No treatment or treatment by time interaction was observed for any bone density measures. Deoxypiridinolyne (DPD) was positively correlated with weight (P=0.02). An increase in body mass index (BMI) in the DHEA group was significantly higher at 4 months compared to the control group (P=0.05). Improvement of mood was significantly correlated with weight only in the DHEA group. Despite a significant decrease in DPD, no improvement in bone mineral density was detected. However, patients treated with DHEA benefited from a significant increase in BMI, which was positively correlated with improvement in mood.
authors.affiliation: Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. mikib@tasmc.health.gov.il
authors.forename: Miki
authors.initials: M
authors.lastname: Bloch
authors.forename: Sophia
authors.initials: S
authors.lastname: Ish-Shalom
authors.forename: Yona
authors.initials: Y
authors.lastname: Greenman
authors.forename: Ehud
authors.initials: E
authors.lastname: Klein
authors.forename: Yael
authors.initials: Y
authors.lastname: Latzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D000856:Anorexia Nervosa / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D003687:Dehydroepiandrosterone