title: Relapse of systemic juvenile idiopathic arthritis after influenza vaccination in a patient receiving tocilizumab.
abstract: We report the case of a patient with systemic juvenile idiopathic arthritis (s-JIA) receiving tocilizumab (TCZ) who experienced relapses of s-JIA after receiving influenza vaccination. Systemic symptoms of s-JIA might be masked during TCZ therapy. Careful observation with the monitoring of serum interleukin (IL)-18 and IL-6 levels may be useful.
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Japan. shimizum@staff.kanazawa-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimizu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ueno
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000188:drug therapy; D002675:Child, Preschool; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D012008:Recurrence; D014611:Vaccination
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D007252:Influenza Vaccines; D020382:Interleukin-18; D015850:Interleukin-6; C502936:tocilizumab