title: Lack of association between p53 SNP and FISS in a cat population from Germany.
abstract: One recent study indicates a significant association between certain single nucleotide polymorphisms (SNPs) in the genomic sequence of feline p53 and feline injection-site sarcoma (FISS). The aim of this study was to investigate the correlation between a specific nucleotide insertion in p53 gene and FISS in a German cat population. Blood samples from 150 German cats were allocated to a control group consisting of 100 healthy cats and a FISS-group consisting of 50 cats with FISS. All blood samples were examined for the presence of the SNP in the p53 gene. Results found the T-insertion at SNP 3 in 20.0% of the cats in the FISS-group and 19.2% of cats in the control-group. No statistically significant difference was observed in allelic distribution between the two groups. Further investigations are necessary to determine the association of SNPs in the feline p53 gene and the occurrence of FISS.
authors.affiliation: Clinic of Small Animal Medicine, Center for Clinical Veterinary Medicine, Ludwig Maximilian University, Munich, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Mucha
authors.forename: S
authors.initials: S
authors.lastname: Laberke
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Hirschberger
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002371:Cat Diseases / Q000209:etiology* / Q000235:genetics; D002415:Cats; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D007267:Injections / Q000009:adverse effects / Q000662:veterinary*; D020641:Polymorphism, Single Nucleotide; D012509:Sarcoma / Q000209:etiology / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000209:etiology / Q000662:veterinary*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*; D014612:Vaccines / Q000009:adverse effects
chemical_list: D016159:Tumor Suppressor Protein p53; D014612:Vaccines