title: Directed self-assembly of lipid nanotubes from inverted hexagonal structures.
abstract: Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.
authors.affiliation: Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Gloriastrasse 35, CH-8092 Zurich, Switzerland. sugihara@is.mpg.de
authors.forename: Kaori
authors.initials: K
authors.lastname: Sugihara
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chami
authors.forename: Imre
authors.initials: I
authors.lastname: Derényi
authors.forename: János
authors.initials: J
authors.lastname: Vörös
authors.forename: Tomaso
authors.initials: T
authors.lastname: Zambelli
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D008422:Materials Testing; D044085:Microfluidics / Q000379:methods*; D008968:Molecular Conformation; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D010714:Phosphatidylethanolamines / Q000138:chemical synthesis*; D013499:Surface Properties
chemical_list: C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D010714:Phosphatidylethanolamines