title: RIFL aims to be a new player in lipid metabolism.
abstract: RIFL (refeeding induced in fat and liver) is highly expressed in brown and white fat as well as in liver. In white adipose tissue and liver, RIFL expression is induced by refeeding and is also elevated in ob/ob mice. The function of RIFL is unknown, and there is some evidence to suggest it may be secreted. RIFL expression is induced during adipogenesis in rodent and human model systems, and cellular knockdown and mouse knockout studies demonstrate that RIFL expression correlates with lipid levels. Overall, these studies indicate that RIFL is a new important player in lipid metabolism.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Stephens
mesh_terms: D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics*; D000091306:Angiopoietin-Like Protein 8
chemical_list: D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C000595899:ANGPTL8 protein, mouse; D000091306:Angiopoietin-Like Protein 8