title: Effect of feeding regulation measures for establishing esophageal channel function in neoesophagus created with a nitinol artificial esophagus.
abstract: OBJECTIVE
  This study attempted to observe the effect of feeding regulation measures (FRM) for the construction of an esophageal channel function in a neoesophagus using an artificial nitinol esophagus.
  
  
  METHODS
  Experiments were divided among groups: group 1, receiving FRM; and group 2, the non-feeding regulation measures (NFRM) group.
  
  
  RESULTS
  Ten pigs survived for 6 months without any complications such as anastomotic leakage. The shedding time of the artificial esophagus in group 1 was significantly delayed in comparison with group 2 (>180 ± 0.0 days vs. 75.6 ± 27.1 days, respectively, p<0.05). In group 1, the weight changes at 3 and 6 months postoperation were significantly different in comparison with preoperative values (t = 14.86, 9.17 > 2.78, respectively; p<0.05). In group 2, the weight changes at 3 and 6 months postoperation were significantly different in comparison with preoperative values (t = 7.95, 11.37 > 2.78, respectively; p<0.05).
  
  
  CONCLUSIONS
  FRM not only effectively delayed the shedding time of the artificial esophagus but also played a role in protecting the neoesophagus from stenosis, by functioned as a bougienage after artificial esophagus sloughing. Therefore, FRM is an effective way for establishing a stable eating channel in the neoesophagus when using a nitinol composite artificial esophagus to replace the resected segment of an intrathoracic esophagus.
authors.affiliation: Department of Chest Surgery, The Second Affiliated Hospital of Guangzhou Medical College, Institute of Guangzhou Cardiovascular Diseases, Guangzhou, PR China. liangjh2006@163.com
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Liang
authors.forename: Pin
authors.initials: P
authors.lastname: Cai
authors.forename: Zhon-ran
authors.initials: ZR
authors.lastname: Luo
authors.forename: Xian-liang
authors.initials: XL
authors.lastname: Liang
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000497:Alloys; D000818:Animals; D001187:Artificial Organs; D004435:Eating / Q000502:physiology*; D004947:Esophagus; D011474:Prosthesis Design; D013552:Swine
chemical_list: D000497:Alloys; C013616:nitinol