title: Spatio-temporal organization of replication in bacteria and eukaryotes (nucleoids and nuclei).
abstract: Here we discuss the spatio-temporal organization of replication in eubacteria and eukaryotes. Although there are significant differences in how replication is organized in cells that contain nuclei from those that do not, you will see that organization of replication in all organisms is principally dictated by the structured arrangement of the chromosome. We will begin with how replication is organized in eubacteria with particular emphasis on three well studied model organisms. We will then discuss spatial and temporal organization of replication in eukaryotes highlighting the similarities and differences between these two domains of life.
authors.affiliation: University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom. dean.jackson@manchester.ac.uk
authors.forename: Dean
authors.initials: D
authors.lastname: Jackson
authors.forename: Xindan
authors.initials: X
authors.lastname: Wang
authors.forename: David Z
authors.initials: DZ
authors.lastname: Rudner
mesh_terms: D018407:Bacterial Physiological Phenomena; D002467:Cell Nucleus / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology* / Q000648:ultrastructure; D004261:DNA Replication / Q000502:physiology*; D056890:Eukaryota / Q000502:physiology*; D008954:Models, Biological; D015530:Nuclear Matrix / Q000502:physiology; D013997:Time Factors