title: Impact of pre-implant lower urinary tract symptoms on postoperative urinary morbidity after permanent prostate brachytherapy.
abstract: OBJECTIVE
  To assess the impact of baseline lower urinary tract symptoms on postoperative urinary morbidity in patients being treated for prostate cancer with 125-I permanent prostate brachytherapy.
  
  
  METHODS
  A total of 104 prostate cancer patients were enrolled in this study. Their urinary morbidity was followed up using the International Prostate Symptom Score and Expanded Prostate Cancer Index Composite for 12 months or more after permanent prostate brachytherapy. Patients were classified into two groups based on their baseline International Prostate Symptom Score: the low International Prostate Symptom Score group (score ≤ 7) and the high International Prostate Symptom Score group (score ≥ 8). Urinary morbidity was estimated in each group based on the results of the International Prostate Symptom Score and Expanded Prostate Cancer Index Composite measured before permanent prostate brachytherapy, and at 1, 3, 6, 9 and 12 months after the end of all radiation therapy.
  
  
  RESULTS
  The overall mean total International Prostate Symptom Score, International Prostate Symptom Score quality of life score, and urinary-related scores for Expanded Prostate Cancer Index Composite were significantly worse at 1 month after the end of treatment, but they improved gradually after the treatment and recovered to the baseline level within 12 months. Even in the high-International Prostate Symptom Score group, the International Prostate Symptom Score and International Prostate Symptom Score Quality of Life score were significantly worse at 1-3 months after permanent prostate brachytherapy, and then recovered to the baseline level without prolongation. Although the urination-related Expanded Prostate Cancer Index Composite score in the high-International Prostate Symptom Score group was significantly worse at 1 month after permanent prostate brachytherapy in comparison with that in the low-International Prostate Symptom Score group, it recovered to the baseline level without prolongation.
  
  
  CONCLUSIONS
  The present findings suggest that the presence of lower urinary tract symptoms before implantation does not prolong urinary morbidity after permanent prostate brachytherapy.
authors.affiliation: Department of Urology, Integrated Health Sciences, Institute of Biochemical & Health Sciences, Hiroshima University, Hiroshima, Japan. teishimaj@yahoo.co.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Teishima
authors.forename: Hideo
authors.initials: H
authors.lastname: Iwamoto
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Shoji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masumoto
authors.forename: Shogo
authors.initials: S
authors.lastname: Inoue
authors.forename: Kanao
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kajiwara
authors.forename: Akio
authors.initials: A
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D016009:Chi-Square Distribution; D006801:Humans; D007457:Iodine Radioisotopes; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D053448:Prostatism / Q000209:etiology*; D011788:Quality of Life; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes