title: [Treatment of HIV-infection by means of gene therapy].
abstract: Current methods of HIV treatment can contain a progression of the disease; however they do not lead to a cure. Lifelong antiretroviral therapy is therefore necessary, leading to problems of cost and toxicity of chemical drugs. The recent advances in science have allowed a new approach to the HIV-treatment - gene therapy. In the present publication we focus on one strategy of the gene therapy called "intracellular immunization". The strategy is based on the introducing of antiviral genes into the HIV-sensitive cells. We highlight the mechanisms of action of various antiviral genetic agents and discuss some issues concerning target cells and genes delivery. Finally we summarize the results of certain gene therapy clinical trials.
authors.forename: D V
authors.initials: DV
authors.lastname: Glazkova
authors.forename: E V
authors.initials: EV
authors.lastname: Bogoslovskaia
authors.forename: M L
authors.initials: ML
authors.lastname: Markelov
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulin
authors.forename: V V
authors.initials: VV
authors.lastname: Pokrovskiĭ
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002986:Clinical Trials as Topic; D005544:Forecasting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D006801:Humans
chemical_list: D019380:Anti-HIV Agents