title: Clinical Inquiry. Do inhaled steroids reduce bone mineral density and increase fracture risk?
abstract: No, except perhaps at high doses. Inhaled corticosteroids at low to medium doses (<1500 mcg beclomethasone hydrofluoroalkane per day) for asthma and chronic obstructive pulmonary disease don't increase the risk of significant bone loss or fracture at 2 to 3 years follow-up. Higher doses, however, may raise the risk of nontraumatic fracture over 1 to 4 years of follow-up.
authors.affiliation: Family Medicine of Southwest Washington, Vancouver, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Wheelock
authors.forename: Justin
authors.initials: J
authors.lastname: Glass
authors.forename: Leilani
authors.initials: L
authors.lastname: St Anna
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D015519:Bone Density / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D005260:Female; D005598:Fractures, Spontaneous / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
chemical_list: D000305:Adrenal Cortex Hormones