title: Childhood physical abuse as a common risk factor for depression and thyroid dysfunction in the earlier postpartum.
abstract: Childhood abuse is a powerful risk factor for developing postpartum depression in adulthood, and recently it has been associated to thyroid dysfunction in postpartum depressive women. The purpose of this study was to investigated the effects of childhood abuse on thyroid status and depressive symptomatology in two hundred and thirty-six (n=236) postpartum women 24-48h after delivery. The Early-Trauma-Inventory Self-Report was used to assess the presence of childhood abuse and the Edinburgh Postpartum Depression Scale (EPDS) to evaluate depressive symptomatology (EPDS≥11). Free thyroxin (fT4) and thyroid-stimulating hormone (TSH) were measured. Thyroid dysfunction (TD) was defined as altered TSH or TSH and fT4. Socio-demographic, reproductive, and psychopathological variables were also collected. Multivariate analysis shows that childhood physical abuse increases by four times the risk for TD (OR: 3.95, 95% CI: 1.23-12.71) and five times the risk for depressive symptomatology (OR: 5.45, 95% CI: 2.17-13.66) in the earlier postpartum. Our findings suggest that women with history of childhood physical abuse are particularly at-risk for thyroid dysfunction and depressive symptomatology 24-48h after delivery. The assessment of childhood abuse in the perinatal period is important to identify women at-risk for physical and mental health problems in this period.
authors.affiliation: Unit of Perinatal Psychiatry and Gender Research, Hospital Clinic Universitari of Barcelona, IDIBAPS, Barcelona 08028, Spain. plaza.estrade@gmail.com
authors.forename: Anna
authors.initials: A
authors.lastname: Plaza
authors.forename: Lluïsa
authors.initials: L
authors.lastname: Garcia-Esteve
authors.forename: Anna
authors.initials: A
authors.lastname: Torres
authors.forename: Carlos
authors.initials: C
authors.lastname: Ascaso
authors.forename: Estel
authors.initials: E
authors.lastname: Gelabert
authors.forename: María
authors.initials: M
authors.lastname: Luisa Imaz
authors.forename: Purificación
authors.initials: P
authors.lastname: Navarro
authors.forename: Manuel
authors.initials: M
authors.lastname: Valdés
authors.forename: Rocío
authors.initials: R
authors.lastname: Martín-Santos
mesh_terms: D000328:Adult; D054523:Adult Survivors of Child Abuse; D019052:Depression, Postpartum / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013959:Thyroid Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013972:Thyrotropin; D013974:Thyroxine