title: How p53 wields the scales of fate: arrest or death?
abstract: Understanding how the tumor suppressor p53 induces cell cycle arrest or apoptosis is critical for developing chemotherapeutic strategies. We have generated targeted transgenic reporter mice with which we can study p53 activity at specific promoters, and propose a model in which p53 protein conformation is key to target gene selection.
authors.affiliation: p53 Laboratory, Agency for Science, Technology and Research, Singapore.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Goh
authors.forename: David P
authors.initials: DP
authors.lastname: Lane
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D016923:Cell Death; D005786:Gene Expression Regulation; D049452:Green Fluorescent Proteins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D011487:Protein Conformation; D020218:Response Elements; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins