title: [Nerve growth factor as a biomarker in the diagnosis and treatment of overactive bladder (OAB)].
abstract: Nerve growth factor is a complex regulator of neural plasticity along the micturition pathways. The aim of this review is to summarize the current evidence for a role of NGF in urinary bladder function both in experimental and clinical settings. There is bulk of strong evidence that experimental administration of NGF elicits the symptoms of increased sensation, urgency and bladder hyperreflexia which strongly resemble overactive bladder syndrome (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS). Therefore in human studies there are attempts to employ urinary NGF levels as a diagnostic marker in various forms of OAB and IC/PBS. It has been shown that urinary NGF levels are correlated with severity of OAB symptoms and in patients successfully treated with antimuscarinics agents or detrusor botulinum toxin injection, urinary NGF levels decrease significantly in association with reduction of urgency severity
authors.affiliation: II Katedra i Klinika Ginekologii Uniwersytetu Medycznego w Lublinie, Polska. kaskarze@go2.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jankiewicz
authors.forename: Beata
authors.initials: B
authors.lastname: Kulik-Rechberger
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Nowakowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Rechberger
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D006801:Humans; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D020932:Nerve Growth Factor / Q000378:metabolism*; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism*; D009465:Neuromuscular Agents / Q000627:therapeutic use; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism*; D001745:Urinary Bladder Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D014563:Urodynamics
chemical_list: D015415:Biomarkers; D018727:Muscarinic Antagonists; D009465:Neuromuscular Agents; D020932:Nerve Growth Factor; D019274:Botulinum Toxins, Type A