title: Medical management of Charcot arthropathy.
abstract: Charcot arthropathy is a major complication of diabetes and it poses management challenges to health care professionals. Early diagnosis and timely intervention are essential for improved outlook of these patients. Casting therapy has been accepted as the mainstay treatment of the acute Charcot foot, although there are still controversies regarding its duration, the choice of removable and non-removable device and weight-bearing casts vs. non-weight-bearing casts. Two groups of antiresorptive therapies have been evaluated in the treatment of the acute Charcot foot, bisphosphonates (intravenous and oral) and calcitonin. These therapies have clearly shown a reduction of bone turnover, although, they have not shown a significant effect on temperature reduction. Current evidence to support their use is weak. An anabolic agent to speed up clinical resolution and fracture healing may be helpful and a clinical trial to evaluate the possible benefit of 1-84 recombinant human parathyroid hormone on fracture healing in the acute Charcot foot is in progress. This paper summarises the current approach to medical management of acute Charcot arthropathy with specific emphasis on casting and pharmacological therapy. Emerging new studies of the pathogenesis of this condition are also discussed.
authors.affiliation: Diabetic Foot Clinic, King's College Hospital, London, UK. petrovanl@yahoo.com
authors.forename: N L
authors.initials: NL
authors.lastname: Petrova
authors.forename: M E
authors.initials: ME
authors.lastname: Edmonds
mesh_terms: D001177:Arthropathy, Neurogenic / Q000534:rehabilitation / Q000628:therapy*; D002116:Calcitonin / Q000494:pharmacology / Q000627:therapeutic use*; D002370:Casts, Surgical; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000534:rehabilitation / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000534:rehabilitation / Q000628:therapy*; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D012720:Severity of Illness Index; D012881:Skin Temperature; D013997:Time Factors; D016474:Weight-Bearing
chemical_list: D004164:Diphosphonates; D010281:Parathyroid Hormone; D002116:Calcitonin