title: Raman spectroscopy provides a powerful, rapid diagnostic tool for the detection of tuberculous meningitis in ex vivo cerebrospinal fluid samples.
abstract: In this letter, we propose a novel method for diagnosis of tuberculous meningitis using Raman spectroscopy. The silicate Raman signature obtained from Mycobacterium tuberculosis positive cases enables specific and sensitive detection of tuberculous meningitis from acquired cerebrospinal fluid samples. The association of silicates with the tuberculosis mycobacterium is discussed. We envision that this new method will facilitate rapid diagnosis of tuberculous meningitis without application of exogenous reagents or dyes and can be aptly used as a complementary screening tool to the existing gold standard methods.
authors.forename: R
authors.initials: R
authors.lastname: Sathyavathi
authors.forename: Narahara Chari
authors.initials: NC
authors.lastname: Dingari
authors.forename: Ishan
authors.initials: I
authors.lastname: Barman
authors.forename: P S R
authors.initials: PS
authors.lastname: Prasad
authors.forename: Subhashini
authors.initials: S
authors.lastname: Prabhakar
authors.forename: D
authors.initials: D
authors.lastname: Narayana Rao
authors.forename: Ramachandra R
authors.initials: RR
authors.lastname: Dasari
authors.forename: Jayanthi
authors.initials: J
authors.lastname: Undamatla
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013059:Spectrum Analysis, Raman; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid* / Q000175:diagnosis*