title: Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua.
abstract: A novel sterically congested Lycopodium alkaloid named lycopalhine A (1) that possesses a fused hexacyclic (5/5/5/6/6/6) ring system comprising a 5,9-diaza-tricyclo[6.2.1.0(4,9)]undecane moiety and a tricyclo[5.2.1.0(4,8)]decane moiety was isolated from Palhinhaea cernua L. The structure and absolute configuration were determined by spectroscopic and computational methods.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors.forename: Liao-Bin
authors.initials: LB
authors.lastname: Dong
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Xu
authors.initials: X
authors.lastname: Deng
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D032502:Lycopodium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000470:Alkaloids; D001952:Bridged-Ring Compounds; D002800:Cholinesterase Inhibitors; D002091:Butyrylcholinesterase