title: Polyclonal serum-free light chains elevation in HIV-infected patients.
abstract: We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.
authors.affiliation: National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Rome, Italy. michele.bibas@inmi.it
authors.forename: Michele
authors.initials: M
authors.lastname: Bibas
authors.forename: Patrizia
authors.initials: P
authors.lastname: Lorenzini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cozzi-Lepri
authors.forename: Andrea
authors.initials: A
authors.lastname: Calcagno
authors.forename: Simona
authors.initials: S
authors.lastname: di Giambenedetto
authors.forename: Andrea
authors.initials: A
authors.lastname: Costantini
authors.forename: Antonella
authors.initials: A
authors.lastname: Castagna
authors.forename: Vinicio
authors.initials: V
authors.lastname: Manfrin
authors.forename: Antonella D
authors.initials: AD
authors.lastname: Monforte
authors.forename: Andrea
authors.initials: A
authors.lastname: Antinori
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000276:immunology*; D007146:Immunoglobulin lambda-Chains / Q000276:immunology*; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral; D019562:Viral Load / Q000276:immunology*
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007155:Immunologic Factors; D012367:RNA, Viral