title: Prototheca wickerhamii as a cause of neuroinfection in a child with congenital hydrocephalus. First case of human protothecosis in Poland.
abstract: This report describes a rare case of neuroinfection due to Prototheca wickerhamii in a child with severe, congenital hydrocephalus. The infection resolved completely after the patient was treated with oral ketoconazole, followed by intravenous fluconazole and amphotericin B. A probable source of infection was contamination during ventriculoperitoneal drain care procedures.
authors.affiliation: Department of Clinical Microbiology, Children's University Hospital of Kraków, Kraków, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Zak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jagielski
authors.forename: Stanisław
authors.initials: S
authors.lastname: Kwiatkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Bielecki
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D018744:DNA, Plant / Q000737:chemistry / Q000235:genetics; D015725:Fluconazole / Q000008:administration & dosage; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D006849:Hydrocephalus / Q000150:complications*; D007223:Infant; D007654:Ketoconazole / Q000008:administration & dosage; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D011044:Poland; D011525:Prototheca / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D018744:DNA, Plant; D000666:Amphotericin B; D015725:Fluconazole; D007654:Ketoconazole