title: Cytotoxic terpenes from the stems of Dipterocarpus obtusifolius collected in Cambodia.
abstract: From the stems of Dipterocarpus obtusifolius, five new triterpenes, 3-oxo-20-hydroxy-30α-methyl,17(29)α-epoxy-28-norlupane (1), 3-oxo-20-hydroxy-30β-methyl-17(29)α-epoxy-28-norlupane (2), 3,20-dioxo-28,29-norlupan-17α-ol (3), 27-demethyl-20(S)-dammar-23-ene-20-ol-3,25-dione (4), and 3-epi-cecropic acid (5) together with 13 known compounds including diterpene, sesquiterpenes and triterpenes were isolated and characterized. All isolates were tested for their cytotoxicities against a small panel of human cancer cell lines. Of the tested compounds, compounds 4-11 were found to be cytotoxic against one or more human cancer cell lines.
authors.affiliation: University of Science & Technology, Daejeon 305-806, Korea.
authors.forename: Piseth
authors.initials: P
authors.lastname: Khiev
authors.forename: Ok-Kyoung
authors.initials: OK
authors.lastname: Kwon
authors.forename: Hyuk-Hwan
authors.initials: HH
authors.lastname: Song
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Kyung-Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002160:Cambodia; D045744:Cell Line, Tumor; D002853:Chromatography, Liquid; D002942:Circular Dichroism; D053958:Dipterocarpaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes