title: Interleukin-1 beta gene polymorphisms and preterm birth.
abstract: OBJECTIVE
  To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth.
  
  
  METHODS
  In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth.
  
  
  RESULTS
  A significant association was found between the presence of the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6 [0.3-1.0]). No significant association was found between the IL1B -511C>T polymorphism and preterm birth (p=0.471, OR 1.3 [0.7-2.3]).
  
  
  CONCLUSIONS
  Our findings suggest that the IL1B +3953C>T polymorphism is associated with a risk reduction for preterm birth in Caucasian women, possibly by altering the inflammatory response during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Vienna General Hospital, Vienna, Austria. maximilian.schmid@meduniwien.ac.at
authors.forename: Maximilian
authors.initials: M
authors.lastname: Schmid
authors.forename: Peter
authors.initials: P
authors.lastname: Haslinger
authors.forename: Susanne
authors.initials: S
authors.lastname: Stary
authors.forename: Heinz
authors.initials: H
authors.lastname: Leipold
authors.forename: Christian
authors.initials: C
authors.lastname: Egarter
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
mesh_terms: D000328:Adult; D000483:Alleles; D001317:Austria; D016022:Case-Control Studies; D060467:Disease Resistance; D005091:Exons; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D005787:Gene Frequency; D056726:Genetic Association Studies; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D007752:Obstetric Labor, Premature / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D044465:White People; D055815:Young Adult
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta