title: Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production.
abstract: We herein report comparative analysis of two versions of the biosynthetic gene clusters of antimycins, a natural product family possessing up to 44 distinct entities. The biosynthetic pathway of antimycins is amenable to the high structural variation of the substrates, supported by successes in heterologous expression of the ant cluster and in fluorine incorporation. The latter facilitated the investigation of the structure-activity relationship into the usually invariable 3-formamidosalicylic acid moiety of the molecules.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Lihan
authors.initials: L
authors.lastname: Zhang
authors.forename: Takuya
authors.initials: T
authors.lastname: Ito
authors.forename: Xudong
authors.initials: X
authors.lastname: Qu
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Awakawa
authors.forename: Ikuro
authors.initials: I
authors.lastname: Abe
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry; D053898:Biosynthetic Pathways / Q000235:genetics; D005798:Genes, Bacterial; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; C032456:antimycin; D000968:Antimycin A