title: Splenic rupture and intracranial haemorrhage in a haemophilic neonate: case report and literature review.
abstract: Splenic rupture and intracranial haemorrhage are life-threatening conditions infrequently encountered in neonates without history of birth trauma. External manifestations of birth trauma; namely, capput succadeneum and cephalhematoma, when present raise suspicions for more serious intracranial or visceral damage. Rupture of normal spleen without an obvious source of trauma in haemophilic neonate is a rare event. The concurrence of both conditions and the unusual presentation make this case a rare one that is seldom encountered in the literature. Additionally, when splenic rupture occurs, the consensus is to employ all non-operative techniques aimed at salvaging the spleen, thus avoiding the immune-compromised state associated with splenectomy. However, in this case, we present a 3-day-old male with family history of haemophilia A, who was diagnosed with splenic rupture and bilateral subdural haematomas and underwent splenectomy, albeit with post-operative complications, in light of haemodynamic instability and high ongoing transfusion requirements.
authors.affiliation: Department of Surgery, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Adamu
authors.forename: Armand
authors.initials: A
authors.lastname: Asarian
authors.forename: Philip
authors.initials: P
authors.lastname: Xiao
mesh_terms: D003029:Coagulants / Q000008:administration & dosage; D005169:Factor VIII / Q000008:administration & dosage; D006400:Hematocrit; D046648:Hematoma, Subdural, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000150:complications*; D008297:Male; D012422:Rupture, Spontaneous; D013156:Splenectomy; D013161:Splenic Rupture / Q000209:etiology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D003029:Coagulants; D005169:Factor VIII