title: Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS.
abstract: Disseminated histoplasmosis is an emerging infection in patients with cellular immune deficiency in non-endemic countries, caused by the migration from endemic regions and the development of travels. Diagnosis can be challenging in this context because rapid diagnostic tools such as Histoplasma antigen detection or appropriate molecular tools are generally unavailable, serology is often negative in immunosuppressed patients, and isolation of the fungus from cultures often takes several weeks. Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker - Pasteur, Paris, France. sebastien.riviere@sat.aphp.fr
authors.forename: Sébastien
authors.initials: S
authors.lastname: Rivière
authors.forename: Blandine
authors.initials: B
authors.lastname: Denis
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: Fanny
authors.initials: F
authors.lastname: Lanternier
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000097:blood; D001230:Aspergillus / Q000276:immunology*; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006678:HIV / Q000276:immunology*; D006658:Histoplasma / Q000276:immunology*; D006660:Histoplasmosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006801:Humans; D008351:Mannans / Q000097:blood*
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose