title: The BioIntelligence Framework: a new computational platform for biomedical knowledge computing.
abstract: Breakthroughs in molecular profiling technologies are enabling a new data-intensive approach to biomedical research, with the potential to revolutionize how we study, manage, and treat complex diseases. The next great challenge for clinical applications of these innovations will be to create scalable computational solutions for intelligently linking complex biomedical patient data to clinically actionable knowledge. Traditional database management systems (DBMS) are not well suited to representing complex syntactic and semantic relationships in unstructured biomedical information, introducing barriers to realizing such solutions. We propose a scalable computational framework for addressing this need, which leverages a hypergraph-based data model and query language that may be better suited for representing complex multi-lateral, multi-scalar, and multi-dimensional relationships. We also discuss how this framework can be used to create rapid learning knowledge base systems to intelligently capture and relate complex patient data to biomedical knowledge in order to automate the recovery of clinically actionable information.
authors.affiliation: The Translational Genomics Research Institute (TGen), Center for BioIntelligence, Phoenix, AZ 85004, USA.
authors.forename: Toni
authors.initials: T
authors.lastname: Farley
authors.forename: Jeff
authors.initials: J
authors.lastname: Kiefer
authors.forename: Preston
authors.initials: P
authors.lastname: Lee
authors.forename: Daniel
authors.initials: D
authors.lastname: Von Hoff
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: Charles
authors.initials: C
authors.lastname: Colbourn
authors.forename: Spyro
authors.initials: S
authors.lastname: Mousses
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D057225:Data Mining; D003628:Database Management Systems; D023281:Genomics; D006801:Humans; D008498:Medical Record Linkage; D008962:Models, Theoretical; D057285:Precision Medicine; D012660:Semantics; D012984:Software; D049490:Systems Biology; D057170:Translational Research, Biomedical