title: Phosphodiesterases and cyclic GMP regulation in heart muscle.
abstract: The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, regulate this signaling in the heart. This review details new insights regarding how these PDEs modulate cGMP and cGK-1 to influence heart function and chronic stress responses, and how their inhibition may provide potential therapeutic benefits.
authors.affiliation: Division of Cardiology, Department of Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA.
authors.forename: Dong I
authors.initials: DI
authors.lastname: Lee
authors.forename: David A
authors.initials: DA
authors.lastname: Kass
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism*; D062965:Cyclic GMP-Dependent Protein Kinase Type I / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
chemical_list: D062965:Cyclic GMP-Dependent Protein Kinase Type I; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP