title: Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
abstract: OBJECTIVE
  To evaluate the association of risk and age at onset (AAO) of Alzheimer disease (AD) with single-nucleotide polymorphisms (SNPs) in the chromosome 19 region including apolipoprotein E (APOE) and a repeat-length polymorphism in TOMM40 (poly-T, rs10524523).
  
  
  METHODS
  Conditional logistic regression models and survival analysis.
  
  
  METHODS
  Fifteen genome-wide association study data sets assembled by the Alzheimer's Disease Genetics Consortium.
  
  
  METHODS
  Eleven thousand eight hundred forty AD cases and 10 931 cognitively normal elderly controls.
  
  
  METHODS
  Association of AD risk and AAO with genotyped and imputed SNPs located in an 800-Mb region including APOE in the entire Alzheimer's Disease Genetics Consortium data set and with the TOMM40 poly-T marker genotyped in a subset of 1256 cases and 1605 controls.
  
  
  RESULTS
  In models adjusting for APOE ε4, no SNPs in the entire region were significantly associated with AAO at P.001. Rs10524523 was not significantly associated with AD or AAO in models adjusting for APOE genotype or within the subset of ε3/ε3 subjects.
  
  
  CONCLUSIONS
  APOE alleles ε2, ε3, and ε4 account for essentially all the inherited risk of AD associated with this region. Other variants including a poly-T track in TOMM40 are not independent risk or AAO loci.
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA.
authors.forename: Gyungah
authors.initials: G
authors.lastname: Jun
authors.forename: Badri N
authors.initials: BN
authors.lastname: Vardarajan
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Buros
authors.forename: Chang-En
authors.initials: CE
authors.lastname: Yu
authors.forename: Michele V
authors.initials: MV
authors.lastname: Hawk
authors.forename: Beth A
authors.initials: BA
authors.lastname: Dombroski
authors.forename: Paul K
authors.initials: PK
authors.lastname: Crane
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Lunetta
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000401:mortality; D001057:Apolipoproteins E / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D015331:Cohort Studies; D042622:DNA Repeat Expansion / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D001057:Apolipoproteins E; D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; C400783:TOMM40 protein, human