title: Left ventricular dysfunction is associated with cerebral grey matter injury: an in-vivo brain MRI segmentation study.
abstract: OBJECTIVE
  Patients with heart failure often experience cognitive deficits. The relationship between systolic function and cerebral gray matter injury is unclear.
  
  
  METHODS
  An automated program SIENAX (v2.2) was used to extract brain volume and for segmentation of grey and white matter in subjects with low left ventricular ejection fraction (< 50%) and normal ejection fraction (≥ 50%). T1-weighted spin-echo axial sequences were used for analysis.
  
  
  RESULTS
  14 cases with low left ventricular ejection fraction and 14 age-matched controls were evaluated. A modest correlation between grey matter volume and low left ventricular ejection fraction was demonstrated (r=0.51, p=0.06), not seen with white matter volumes. The mean grey matter volume was 507.4±166.3 ml in the low left ventricular ejection fraction group and 541.3±167.2 ml in the control group (p=0.57).
  
  
  CONCLUSIONS
  Low left ventricular ejection fraction may lead to cerebral grey matter injury. Larger studies including multi-modal MRI and neuropsychological assessments are warranted to explore potential mechanisms.
authors.affiliation: Comprehensive Stroke Program, Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA. pdbhatta@med.wayne.edu
authors.forename: Pratik
authors.initials: P
authors.lastname: Bhattacharya
authors.forename: Fen
authors.initials: F
authors.lastname: Bao
authors.forename: Megha
authors.initials: M
authors.lastname: Shah
authors.forename: Gautam
authors.initials: G
authors.lastname: Ramesh
authors.forename: Ramesh
authors.initials: R
authors.lastname: Madhavan
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
mesh_terms: D000368:Aged; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000150:complications*