title: Preventive effect of Imperatorin on acute lung injury induced by lipopolysaccharide in mice.
abstract: Imperatorin, a linear furanocoumarin, has many pharmacological effects such as antibacterial, anti-inflammatory and antiviral effects. The purpose of this study was to investigate the effect of Imperatorin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with Imperatorin 1h before LPS challenge. We found that the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF) were decreased significantly, and the level of interleukin-10 (IL-10) was up-regulated 8h after Imperatorin treatment. Pretreatment with Imperatorin (15 or 30 mg/kg) decreased lung wet-to-dry weight (W/D) ratio, the number of inflammatory cells and myeloperoxidase (MPO) activities. Additionally, Imperatorin attenuated lung histopathological changes and significantly inhibited the phosphorylation of IκB, JNK, ERK and p38/MAPK. These findings demonstrate that Imperatorin protects against LPS-induced ALI in mice.
authors.affiliation: College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Changchun 130062, People's Republic of China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Sun
authors.forename: Gefu
authors.initials: G
authors.lastname: Chi
authors.forename: Lanan Wassy
authors.initials: LW
authors.lastname: Soromou
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Mingfeng
authors.initials: M
authors.lastname: Guan
authors.forename: Qianchao
authors.initials: Q
authors.lastname: Wu
authors.forename: Dacheng
authors.initials: D
authors.lastname: Wang
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D011564:Furocoumarins / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008171:Lung Diseases / Q000139:chemically induced* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011564:Furocoumarins; D008070:Lipopolysaccharides; C031534:imperatorin