title: Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis.
abstract: Even though deregulation of human MLF1, the founding member of the Myeloid Leukemia Factor family, has been associated with acute myeloid leukemia, the function and mode of action of this family of genes have remained rather mysterious. Yet, recent findings in Drosophila shed new light on their biological activity and suggest that they play an important role in hematopoiesis and leukemia, notably by regulating the stability of RUNX transcription factors, another family of conserved proteins with prominent roles in normal and malignant blood cell development.
authors.affiliation: Université de Toulouse, UPS, CBD-Centre de Biologie du Développement, Bat4R3, Toulouse, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gobert
authors.forename: Marc
authors.initials: M
authors.lastname: Haenlin
authors.forename: Lucas
authors.initials: L
authors.lastname: Waltzer
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D050657:Core Binding Factor alpha Subunits / Q000378:metabolism*; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins / Q000378:metabolism; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C100852:MLF1 protein, human; C468117:Mlf protein, Drosophila; C484412:Mlf1 protein, mouse; D011506:Proteins