title: Central diabetes insipidus:  an unusual complication in a child with juvenile myelomonocytic leukemia and monosomy 7.
abstract: Central diabetes insipidus (DI) is well-documented as a presenting feature of myelodysplastic syndrome and acute myeloid leukemia in adults. However, DI is unusual in pediatric patients with myeloid malignancies. We report here this rare complication in a child with neurofibromatosis type 1 who developed juvenile myelomonocytic leukemia and monosomy 7. Our case and previously reported cases of DI arising as a complication in myeloid malignancies demonstrate a close association with deletion of chromosome 7. The clinical characteristics and outcomes of these uncommon cases in children are reviewed and discussed.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: Pacharapan
authors.initials: P
authors.lastname: Surapolchai
authors.forename: Shau-Yin
authors.initials: SY
authors.lastname: Ha
authors.forename: Godfrey Chi-Fung
authors.initials: GC
authors.lastname: Chan
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Lukito
authors.forename: Thomas S K
authors.initials: TS
authors.lastname: Wan
authors.forename: Chi-Chiu
authors.initials: CC
authors.lastname: So
authors.forename: Alan Kwok-Shing
authors.initials: AK
authors.lastname: Chiang
mesh_terms: D002648:Child; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D020790:Diabetes Insipidus, Neurogenic / Q000209:etiology*; D005260:Female; D006801:Humans; D054429:Leukemia, Myelomonocytic, Juvenile / Q000150:complications* / Q000235:genetics