title: Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B.
abstract: OBJECTIVE
  The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  Between October 2005 and June 2009, 384 subjects with CHB were enrolled.
  
  
  RESULTS
  Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score=1.773×ALT score+1.599×PIIINP score+0.677×HA score-1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.
  
  
  CONCLUSIONS
  A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB.
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: Hyo Jung
authors.initials: HJ
authors.lastname: Cho
authors.forename: Soon Sun
authors.initials: SS
authors.lastname: Kim
authors.forename: Seun Joo
authors.initials: SJ
authors.lastname: Ahn
authors.forename: Chang Bum
authors.initials: CB
authors.lastname: Bae
authors.forename: Han Gyeol
authors.initials: HG
authors.lastname: Kim
authors.forename: Young Jip
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seung Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Ga Won
authors.initials: GW
authors.lastname: Song
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Yang
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Kim
authors.forename: Young Nyun
authors.initials: YN
authors.lastname: Park
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009336:Necrosis; D012372:ROC Curve; D055815:Young Adult
chemical_list: D015415:Biomarkers