title: Chiral drug analysis using mass spectrometric detection relevant to research and practice in clinical and forensic toxicology.
abstract: This paper reviews analytical approaches published in 2002-2012 for chiral drug analysis and their relevance in research and practice in the field of clinical and forensic toxicology. Separation systems such as gas chromatography, high performance liquid chromatography, capillary electromigration, and supercritical fluid chromatography, all coupled to mass spectrometry, are discussed. Typical applications are reviewed for relevant chiral analytes such as amphetamines and amphetamine-derived designer drugs, methadone, tramadol, psychotropic and other CNS acting drugs, anticoagulants, cardiovascular drugs, and some other drugs. Usefulness of chiral drug analysis in the interpretation of analytical results in clinical and forensic toxicology is discussed as well.
authors.affiliation: Department of Forensic Pharmacology and Toxicology, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Schwaninger
authors.forename: Markus R
authors.initials: MR
authors.lastname: Meyer
authors.forename: Hans H
authors.initials: HH
authors.lastname: Maurer
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D019075:Electrophoresis, Capillary / Q000379:methods; D053593:Forensic Toxicology; D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations