title: A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy.
abstract: We report on a 12-year-old female patient with lipoprotein glomerulopathy (LPG) who was proven to be heterozygous for ApoE2 Kyoto (Arg25Cys). Her family members have the same variant but do not have obvious signs of renal function impairment. Six months of treatment with a statin caused significant clinical improvement in the lipid profile, proteinuria, and renal function. Our case suggests that administration of a statin is a potential therapeutic strategy for improving nephrotic syndrome in patients with LPG.
authors.affiliation: Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taiwan.
authors.forename: Min-Tser
authors.initials: MT
authors.lastname: Liao
authors.forename: I-Jung
authors.initials: IJ
authors.lastname: Tsai
authors.forename: Hui-Teng
authors.initials: HT
authors.lastname: Cheng
authors.forename: Wei-Chou
authors.initials: WC
authors.lastname: Lin
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Chang
authors.forename: Yi-Heng
authors.initials: YH
authors.lastname: Lin
authors.forename: Yong-Kwei
authors.initials: YK
authors.lastname: Tsau
mesh_terms: D017668:Age of Onset; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D053329:Apolipoprotein E2 / Q000235:genetics*; D002648:Child; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D009154:Mutation; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000235:genetics*; D017035:Pravastatin / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D053329:Apolipoprotein E2; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C504713:apolipoprotein E2 (Kyoto); D004656:Enalapril; D017035:Pravastatin; D008775:Methylprednisolone