title: Chemotherapy-related hypersensitivity reaction in Japanese patients with gynecologic malignancy.
abstract: OBJECTIVE
  Chemotherapy-related hypersensitivity reaction seems to be problematic in the safe management of chemotherapy. In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy.
  
  
  METHODS
  Between January 2009 and December 2010, we examined hypersensitivity reaction (> or = grade2) using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. We analyzed the incidence, clinical features, management, and outcome.
  
  
  RESULTS
  We administered over 1,057 infusions (24 regimens) to 205 patients. We found a total of four hypersensitivity reactions (> or = grade 2) cases (carboplatin: 2; nedaplatin: 1; docetaxel: 1). Signs and symptoms were varied. In two cases, the same regimen was rechallenged by using anti-allergic drugs. The docetaxel case was successful. The carboplatin case was not successful.
  
  
  CONCLUSIONS
  Chemotherapy-related hypersensitivity reaction (> or = grade2) does not occur frequently. In the case of platinum, especially, carboplatin, re-administering after hypersensitivity reaction should be done carefully though platinum is a key drug in patients with gynecologic malignancies.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kitada
authors.forename: Y
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Ichimura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Yasui
authors.forename: T
authors.initials: T
authors.lastname: Sumi
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001952:Bridged-Ring Compounds / Q000009:adverse effects; D016190:Carboplatin / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D006801:Humans; D007564:Japan; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects; D012189:Retrospective Studies; D043823:Taxoids / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D009944:Organoplatinum Compounds; D043823:Taxoids; C080625:taxane; C053989:nedaplatin; D016190:Carboplatin