title: Efficient sparse reconstruction algorithm for bioluminescence tomography based on duality and variable splitting.
abstract: Bioluminescence tomography (BLT) can three-dimensionally and quantitatively resolve the molecular processes in small animals in vivo. In this paper, we propose a BLT reconstruction algorithm based on duality and variable splitting. By using duality and variable splitting to obtain a new equivalent constrained optimization problem and updating the primal variable as the Lagrangian multiplier in the dual augmented Lagrangian problem, the proposed method can obtain fast and stable source reconstruction even without the permissible source region and multispectral measurements. Numerical simulations on a mouse atlas and in vivo mouse experiments were conducted to validate the effectiveness and potential of the method.
authors.affiliation: College of Electronic Information & Control Engineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Kebin
authors.initials: K
authors.lastname: Jia
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xueyan
authors.initials: X
authors.lastname: Liu
authors.forename: Jinchao
authors.initials: J
authors.lastname: Feng
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D008962:Models, Theoretical; D009928:Organ Specificity; D041622:Tomography, Optical / Q000379:methods*