title: The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery.
abstract: The aim of this study was to prepare fatty acid salts of chitosan (CS) and to evaluate the salts as matrices for sustained drug release and prolonged gastric retention. CS-laurate and CS-palmitate were formed by mixing saturated CS solution and aqueous solutions of sodium laurate and sodium palmitate, respectively, and collected by centrifugation. They were characterized using Fourier-transform infrared spectroscopy and differential scanning calorimetry. Different matrices as effervescent tablets were prepared using each of these CS-salts, CS and the corresponding physical mixtures of CS and the fatty acids. Sodium bicarbonate as an effervescent agent and ranitidine HCl as a model drug were incorporated into these matrices. In vitro buoyancy and drug dissolution were studied for the matrices in 0.1 M HCl. Tablets with fatty acid salts of CS showed both rapid and prolonged buoyancy (> 8 h). Comparatively, CS tablets exhibited a short floatation period (< 2 h) and tablets were completely disintegrated within 1 h of soaking. In addition, slow and prolonged drug release was achieved from tablets of fatty acid salts of CS with average drug release of 80.1 and 71.8% for CS-laurate and CS-palmitate, respectively. Rapid drug release (> 80% at 1 h) was exhibited by tablets with CS or the physical mixtures.
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman, Jordan. abjaber@ju.edu.jo
authors.forename: Ahmad
authors.initials: A
authors.lastname: Bani-Jaber
authors.forename: Imad
authors.initials: I
authors.lastname: Hamdan
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Alkawareek
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007700:Kinetics; D007848:Laurates / Q000138:chemical synthesis*; D008956:Models, Chemical; D010168:Palmitates / Q000138:chemical synthesis*; D011899:Ranitidine / Q000737:chemistry*; D017693:Sodium Bicarbonate / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods; D014783:Viscosity; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007848:Laurates; D010168:Palmitates; D013607:Tablets; D014867:Water; D011899:Ranitidine; D017693:Sodium Bicarbonate; D048271:Chitosan