title: Three new myrsinol diterpenes from Euphorbia prolifera and their neuroprotective activities.
abstract: Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+ -induced neuronal cell death in SH-SY5Y cells.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Daqing
authors.initials: D
authors.lastname: Jin
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Fang
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry
chemical_list: C576877:2alpha,14alpha-di-O-benzoyl-3beta,5alpha,7beta,10,15beta-penta-O-acetyl-10,18-dihydromyrsinol; C576874:2alpha-O-isobutyryl-3beta,5alpha,7beta,10,15beta-penta-O-acetyl-14alpha-O-benzoyl-10,18-dihydromyrsinol; C576876:2alpha-O-isobutyryl-3beta-O-propion-yl-5alpha,7beta,10,15beta-tetra-O-acetyl-10,18-dihydromyrsinol; D004224:Diterpenes; D018696:Neuroprotective Agents