title: [Singular, systemic, self-reactive IgG patterns related to age: relationship with cerebral malaria susceptibility in exposed subjects residing in an endemic area in Abidjan, Côte-d'Ivoire].
abstract: The impact of autoimmunity on malaria-infection evolution reported by various works has led us to compare reactive patterns of self-dependent systemic IgG from 54 patients aged less than 15 years old to those from 46 subjects older than 15 years. These subjects were divided into 34 Plasmodium falciparum asymptomatic carriers (ACs), 30 cases of uncomplicated malaria (UM), and 36 patients suffering from cerebral malaria (CM) living in the same endemic area. The reactivity of the plasma antibodies against human brain tissue extract was assessed by western blotting. Comparative analysis of reactive bands (linear discriminant analysis, LDA) revealed the existence of patterns that distinguish, among the more susceptible subjects aged less than 15 years old, the different clinical forms. In contrast, in less susceptible subjects aged more than 15 years old, the patterns are homogenous and do not allow the separation of these clinical forms. This self-reactive repertoire might be witnessed as an imprint of the clinical tolerance acquired during the years of living in endemic areas. The singularity of this profile under the age of 15 years might have a prognostic value.
authors.affiliation: Laboratoire d'immunologie EA 2686, université Lille-II, Lille cedex, France. serydasse@yahoo.fr
authors.forename: R
authors.initials: R
authors.lastname: Dassé
authors.forename: D
authors.initials: D
authors.lastname: Lefranc
authors.forename: S
authors.initials: S
authors.lastname: Dubucquoi
authors.forename: P
authors.initials: P
authors.lastname: Dussart
authors.forename: V
authors.initials: V
authors.lastname: Dutoit-Lefèvre
authors.forename: B
authors.initials: B
authors.lastname: Sendid
authors.forename: F
authors.initials: F
authors.lastname: Sombo Mambo
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
authors.forename: L
authors.initials: L
authors.lastname: Prin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D001921:Brain / Q000276:immunology; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire / Q000453:epidemiology; D018450:Disease Progression; D004198:Disease Susceptibility; D019353:Endemic Diseases; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007223:Infant; D016779:Malaria, Cerebral / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D011379:Prognosis; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D009419:Nerve Tissue Proteins