title: [Could we improve notification of adverse drugs reactions in hospital? Assessment of 5 years of network PharmacoMIP's activities].
abstract: BACKGROUND
  Spontaneous reporting of adverse drug reactions (ADR) is fundamental to drug safety surveillance (pharmacovigilance) and assessment of benefit/risk ratio. However, under-reporting remains the limit of the system.
  
  
  OBJECTIVE
  The aim of this study was to assess the effect of regular visits of an Assistant in Clinical Research (CRA) on the improvement of ADR reporting in non-university hospitals.
  
  
  METHODS
  We set up an ADR report collecting system that involved regular visits in non-university hospitals, We began the visits in 2006 in 2 areas (Haute Garonne and Gers), extended to 4 other areas in 2009. We compared the reporting rate (number of reports/number of beds) of total ADRs reported by non-university hospitals in these areas before (one year) and after the start of CRA visits.
  
  
  RESULTS
  A total 2831 of reports were collected by the CRA: 40% were "serious" including two deaths. The results suggest an increase of 100% of the rate of reporting of ADRs.
  
  
  CONCLUSIONS
  This study shows that regular visits increases the number of ADRs reported by non-university hospitals. Further assessment of this procedure is necessary for long term evaluation of its effectiveness.
authors.affiliation: Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Équipe de Recherche de Pharmacoépidémiologie INSERM U1027, Centre Hospitalier Universitaire, Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Jacquot
authors.forename: Mireille
authors.initials: M
authors.lastname: Gony
authors.forename: Dominique
authors.initials: D
authors.lastname: Baudrin
authors.forename: Xavier
authors.initials: X
authors.lastname: Chastel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
authors.forename: Haleh
authors.initials: H
authors.lastname: Bagheri
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000458:organization & administration*; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000401:mortality; D005260:Female; D005602:France; D006276:Health Facility Size; D006761:Hospitals; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D060735:Pharmacovigilance; D058996:Quality Improvement; D000078329:Workforce; D055815:Young Adult