title: Angiogenic biomarkers for prediction of maternal and neonatal complications in suspected preeclampsia.
abstract: OBJECTIVE
  To determine if maternal serum angiogenic factors predict maternal and neonatal complications in women presenting to an acute care setting with suspected preeclampsia.
  
  
  METHODS
  Maternal serum samples were prospectively collected from women with suspected preeclampsia at the time of initial presentation to hospital triage with signs or symptoms of preeclampsia. Soluble fms-like tyrosine kinase-1 (sFlt1), placental growth factor (PlGF), and soluble endoglin (sEng) were measured by ELISA. The primary outcome was a composite of maternal and neonatal complications.
  
  
  RESULTS
  Of 276 women with suspected preeclampsia, 78 developed maternal or neonatal complications. Among women presenting prior to 37 weeks gestation, sFlt1, PlGF, and sEng were significantly different in women who developed maternal and neonatal complications as compared to women without complications. Higher levels of sFlt1, sEng, and the sFlt1:PlGF ratio were associated with an increased odds of complications among women presenting prior to 37 weeks. A multivariable model combining the sFlt1:PlGF ratio with clinical variables was more predictive of complications (AUC 0.91, 95% CI 0.85-0.97) than a model using clinical variables alone (AUC 0.82, 95% CI 0.79-0.90).
  
  
  CONCLUSIONS
  Angiogenic biomarkers associate with maternal and neonatal complications in women with suspected preeclampsia, and may be useful for risk stratification.
authors.affiliation: Department of Obstetrics and Gynecology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: Andreea G
authors.initials: AG
authors.lastname: Moore
authors.forename: Heather
authors.initials: H
authors.lastname: Young
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Keller
authors.forename: Linda R
authors.initials: LR
authors.lastname: Ojo
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.forename: Tiffany A Moore
authors.initials: TA
authors.lastname: Simas
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Maynard
mesh_terms: D000328:Adult; D042501:Angiogenic Proteins / Q000032:analysis / Q000097:blood*; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D011644:Puerperal Disorders / Q000097:blood / Q000175:diagnosis; D014218:Triage / Q000379:methods
chemical_list: D042501:Angiogenic Proteins; D015415:Biomarkers