title: A ratiometric fluorescence sensor for caffeine.
abstract: The dye disodium 3,4:3',4'-bibenzo[b]thiophene-2,2'-disulfonate can be used as a molecular probe for the fluorimetric detection of caffeine in aqueous solution. The fluorescence response is attributed to non-covalent interactions of caffeine with the dye in the ground state and in the excited state. The bimodal interaction allows performing ratiometric measurements with very good selectivity over structurally related analytes. The dye was also used to develop a simple test strip for the visual differentiation of normal and decaffeinated coffee with a standard UV lamp.
authors.affiliation: Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Luisier
authors.forename: Albert
authors.initials: A
authors.lastname: Ruggi
authors.forename: Stephan N
authors.initials: SN
authors.lastname: Steinmann
authors.forename: Laurane
authors.initials: L
authors.lastname: Favre
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gaeng
authors.forename: Clémence
authors.initials: C
authors.lastname: Corminboeuf
authors.forename: Kay
authors.initials: K
authors.lastname: Severin
mesh_terms: D002110:Caffeine / Q000032:analysis*; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D002110:Caffeine