title: Reductive detriflylation of N-triflylamides with Red-Al.
abstract: Reduction of cis-N-triflylaziridines with 10 equiv of Red-Al in toluene at -40 to 0 °C selectively afforded corresponding deprotected parent aziridines in good to high yields. N,N-Dialkyltriflylamides were also successfully cleaved under similar reaction conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. kmiya@ph.tokushima-u.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Md Mahbubul
authors.initials: MM
authors.lastname: Hoque
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ogasa
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D014050:Toluene / Q000737:chemistry*
chemical_list: D001388:Aziridines; D006845:Hydrocarbons, Fluorinated; C579738:N-(1-phenyl-2-phenethyl)trifluoromethanesulfonamide; D013449:Sulfonamides; D014050:Toluene