title: A pH-responsive fluorescent probe and photosensitiser based on a self-quenched phthalocyanine dimer.
abstract: A self-quenched zinc(II) phthalocyanine dimer linked with an acid-sensitive ketal unit has been prepared, which can be activated in an acidic environment (pH = 5.0-6.5) as a result of the cleavage of the ketal linker and separation of the phthalocyanine units, resulting in enhanced fluorescence emission and singlet oxygen production.
authors.affiliation: Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
authors.forename: Mei-Rong
authors.initials: MR
authors.lastname: Ke
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
mesh_terms: D019281:Dimerization; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D042541:Intracellular Space / Q000187:drug effects; D054833:Isoindoles; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D005456:Fluorescent Dyes; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C013647:phthalocyanine