title: Alterations in extracellular tryptophan and dopamine concentrations in rat striatum following peripheral administration of D- and L-tryptophan: an in vivo microdialysis study.
abstract: Incorporation profiles of d-Trp and l-Trp into the striatum following intraperitoneal (i.p.) administration of d-Trp or l-Trp in male Sprague-Dawley rats (100mg/kg) were investigated by using a brain microdialysis technique. Alterations in the extracellular dopamine (DA) concentration in the rat striatum were also examined. Incorporation profiles of d-Trp and l-Trp were almost identical; however, transient DA release was only observed 0-30 min following d-Trp administration. Pretreatment with 3-methylpyrazole-5-carboxylic acid, an inhibitor of d-amino acid oxidase (DAAO), significantly suppressed the DA release induced by d-Trp. These findings suggest that d-Trp-induced DA release may be mediated by certain d-Trp metabolites produced by DAAO.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi-shi, Chiba 274-8510, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yoshihara
authors.forename: Hayato
authors.initials: H
authors.lastname: Otani
authors.forename: Makoto
authors.initials: M
authors.lastname: Tsunoda
authors.forename: Kana
authors.initials: K
authors.lastname: Ishii
authors.forename: Hideaki
authors.initials: H
authors.lastname: Iizuka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ichiba
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukushima
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003605:D-Amino-Acid Oxidase / Q000037:antagonists & inhibitors; D004298:Dopamine / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D017551:Microdialysis; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D011720:Pyrazoles; D014364:Tryptophan; D003605:D-Amino-Acid Oxidase; C005210:5-methylpyrazole-3-carboxylic acid; D004298:Dopamine