title: Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica.
abstract: A methanol extract of the wood of Diospyros burmanica, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major. Subsequent chromatographically resolved fractionation led to the isolation of three novel bisnaphthoquinone analogues, burmanin A, B, and C (1-3), together with nine known compounds (4-12). The structure of 1 was confirmed by X-ray crystallography, and those of 2 and 3 by spectroscopic techniques, including 1D and 2D NMR. The inhibitory activities of the isolates were evaluated against the promastigote forms of Leishmania major and the murine macrophage-like cell line, RAW264.7.
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa 769-2193, Japan. morik@kph.bunri-u.ac.jp
authors.forename: Kanami
authors.initials: K
authors.lastname: Mori-Yasumoto
authors.forename: Ryoko
authors.initials: R
authors.lastname: Izumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Takashi
authors.initials: T
authors.lastname: Ooi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Agatsuma
authors.forename: Takenori
authors.initials: T
authors.lastname: Kusumi
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D029788:Diospyros / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D018320:Leishmania major / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D002052:Myanmar; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014934:Wood / Q000737:chemistry
chemical_list: D000981:Antiprotozoal Agents; D009284:Naphthols; D009285:Naphthoquinones; D010936:Plant Extracts