title: Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity.
abstract: To investigate the role of viral load in the pathogenesis of hemorrhagic fever with renal syndrome, the Hantaan virus RNA load in plasma from 101 patients was quantiﬁed, and the relationships between viral load and disease course, severity, and level of specific humoral immunity were analyzed. The viral load, detectable in 79 patients, ranged from 3.43 to 7.33 log10 copies/mL of plasma. In the early stage of disease, patients in severe/critical group were found to have higher viral loads than those in the mild/moderate group (5.90 vs 5.03 log10 copies/mL; P = .001), suggesting an association between Hantaan virus load and disease severity.
authors.affiliation: Department of Immunology, Xijing Hospital, Xi’an, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yi
authors.forename: Zhuwei
authors.initials: Z
authors.lastname: Xu
authors.forename: Ran
authors.initials: R
authors.lastname: Zhuang
authors.forename: Jiuping
authors.initials: J
authors.lastname: Wang
authors.forename: Yusi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Guolin
authors.initials: G
authors.lastname: Yan
authors.forename: Fanglin
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhikai
authors.initials: Z
authors.lastname: Xu
authors.forename: Angang
authors.initials: A
authors.lastname: Yang
authors.forename: Boquan
authors.initials: B
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D005260:Female; D018063:Hantaan virus / Q000302:isolation & purification*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000473:pathology* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000302:isolation & purification*; D012720:Severity of Illness Index; D019562:Viral Load; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral