title: Sperm quality in adult male rats exposed to cadmium in utero and lactation.
abstract: Recent studies indicate that several anomalies of the male reproductive system may be produced by acute or chronic exposure to chemical substances released into the environment, attributed to increased industrial development. Among these substances are trace metals such as cadmium (Cd). The aim of this study was to assess reproductive parameters in adult male rats whose mothers were exposed to Cd during pregnancy and lactation. For this, pregnant rats were divided into two experimental groups: treated rats, which received ad libitum cadmium acetate (CdAc) solution in distilled water (10 mg Cd/L), and control rats, which received sodium acetate (NaAc) solution in distilled water (equimolar to the CdAc). The results showed that the exposure to Cd in utero and through lactation adversely affected sperm quality of adult rats, as evidenced by compromised sperm morphology and motility and increased rate of cell death in testis.
authors.affiliation: Graduate Program in General and Applied Biology , Institute of Biosciences, UNESP-Univ Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Thais
authors.initials: T
authors.lastname: Petrochelli Banzato
authors.forename: Antonio Francisco
authors.initials: AF
authors.lastname: Godinho
authors.forename: Elaine Cristina Mathias
authors.initials: EC
authors.lastname: da Silva Zacarin
authors.forename: Juliana Elaine
authors.initials: JE
authors.lastname: Perobelli
authors.forename: Carla
authors.initials: C
authors.lastname: Dal Bianco Fernandez
authors.forename: Ana Paula Alves
authors.initials: AP
authors.lastname: Favareto
authors.forename: Wilma
authors.initials: W
authors.lastname: De Grava Kempinas
mesh_terms: D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007774:Lactation; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D055101:Semen Analysis; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology
chemical_list: D002104:Cadmium