title: Head and neck tumors: assessment of perfusion-related parameters and diffusion coefficients based on the intravoxel incoherent motion model.
abstract: OBJECTIVE
  IVIM MR imaging provides perfusion and diffusion information with a single diffusion-weighted MR image. We determined whether PP and D differ among various types of head and neck tumors.
  
  
  METHODS
  The study cohort included 123 head and neck tumors: 30 SCCs, 28 benign and 20 malignant SG tumors, 36 lymphomas, and 9 schwannomas. The D and PP values were determined by using b-values of 0, 500, and 1000 s/mm(2) based on the IVIM model.
  
  
  RESULTS
  The PP values (lymphomas, 0.09 ± 0.04; SCCs, 0.15 ± 0.04; and malignant SG tumors, 0.22 ± 0.07) and D values (0.47 ± 0.07 × 10(-3) mm(2)/s, 0.82 ± 0.17 × 10(-3) mm(2)/s, and 1.03 ± 0.16 × 10(-3) mm(2)/s, respectively) were significantly different among the malignant tumors (P < .01). These values were also significantly different between pleomorphic adenomas (0.13 ± 0.02 and 1.44 ± 0.39 × 10(-3) mm(2)/s) and Warthin tumors (0.19 ± 0.04 and 0.73 ± 0.22 × 10(-3) mm(2)/s) (P < .001). The PP values of malignant SG tumors were significantly different from those of pleomorphic adenomas (P = .001) and the D values of the malignant SG tumors were significantly different from those of pleomorphic adenomas (P = .002) and Warthin tumors (P = .007). Schwannomas had large PP (0.23 ± 0.08) and D values (1.26 ± 0.20 × 10(-3) mm(2)/s), greatly overlapping those of some SG tumor types.
  
  
  CONCLUSIONS
  Head and neck tumors had distinctive PP and D values by using IVIM MR imaging.
authors.affiliation: Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sumi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000235:Adenolymphoma / Q000473:pathology; D000236:Adenoma / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping / Q000379:methods; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019786:Gadolinium DTPA; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008224:Lymphoma, Follicular / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009442:Neurilemmoma / Q000473:pathology; D055420:Perfusion Imaging / Q000379:methods*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA