title: Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway.
abstract: Cancer is one of the leading causes of death worldwide. Since dietary factors have been connected to a reduced risk of a diversity of human cancers, in this study we investigated the effects of tomato powder (TP) on the development of azoxymethane (AOM)-induced colorectal cancer in Wistar rats, and possible mechanism(s) by which TP shows its chemopreventive activity. Here we show that TP added to feed at 5% rate decreases the rate of aberrant crypt foci (ACF) and reduces the development of adenocarcinoma and growth of AOM-induced colorectal cancer in rats. In addition, we demonstrate that TP supplementation shows its chemopreventive activities through inhibition of cyclooxygenase-2 (COX-2) expression via NF-κB pathway and promotion of apoptosis, as well as regulating Nrf2/HO-1 signaling pathway in colorectal tissue of AOM-treated rats. Our findings identify an intimate connection between dietary supplementation of TP and the decreased risk of colorectal cancer in rats, and suggest that consumption of TP would be a natural candidate for the prevention of colorectal cancer in men.
authors.affiliation: Department of Biology, Faculty of Science, Firat University, Elazig, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aslan
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Tuzcu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yabas
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Bahcecioglu
authors.forename: Ibrahim Hanifi
authors.initials: IH
authors.lastname: Ozercan
authors.forename: Omer
authors.initials: O
authors.lastname: Kucuk
authors.forename: Kazim
authors.initials: K
authors.lastname: Sahin
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001397:Azoxymethane / Q000009:adverse effects; D049109:Cell Proliferation / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D018551:Solanum lycopersicum / Q000737:chemistry*; D051267:NF-E2-Related Factor 2 / Q000235:genetics / Q000378:metabolism*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D016588:Anticarcinogenic Agents; D051267:NF-E2-Related Factor 2; D016328:NF-kappa B; C495637:Nfe2l2 protein, rat; D010936:Plant Extracts; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; D001397:Azoxymethane