title: Hydroxyurea induced dermatomyositis-like eruption.
abstract: Medication-induced dermatomyositis (DM) is rare, but a recent review highlighted hydroxyurea (HU) as the most common inciting agent. To aid diagnosis, HU-induced DM-like eruption (HU DM-LE) forms a distinct dermopathy where the typical cutaneous features of DM are without systemic involvement and co-exist with other HU-induced cutaneous findings such as severe xerosis, atrophy, stomatitis, cutaneous and mucosal ulceration and melanonychia. On cessation of HU the DM-LE clears avoiding unnecessary immunosuppression and demonstrating the importance of consideration of medication aetiology in DM presentations. We present a case report and review of the literature.
authors.affiliation: Mater Misericordiae Hospital, Department of Dermatology, Brisbane, QLD 4101, Australia. taniazappala@gmail.com
authors.forename: Tania M
authors.initials: TM
authors.lastname: Zappala
authors.forename: Karl
authors.initials: K
authors.lastname: Rodins
authors.forename: James
authors.initials: J
authors.lastname: Muir
mesh_terms: D000368:Aged; D000749:Anemia, Megaloblastic / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003882:Dermatomyositis / Q000139:chemically induced* / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D055728:Primary Myelofibrosis / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea