title: Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review.
abstract: BACKGROUND
  A recent increase in reports of acute hepatitis C virus infection (HCV) in HIV-infected and HIV-uninfected men who have sex with men (MSM), with the sole risk factor being sexual exposure, has led to routine screening and targeted prevention requests for this population; current evidence for this necessity is unclear.
  
  
  OBJECTIVE
  A systematic review was conducted to assess the incidence of HCV infection among studies conducted in HIV-positive and/or HIV-negative MSM to explore the implications for routine HCV screening.
  
  
  METHODS
  The MEDLINE, EMBASE and BIOSYS databases were searched for the period January 2000 to May 2012, yielding 21 studies. Six conferences were hand-searched for the same period yielding four abstracts.
  
  
  METHODS
  Only studies in English presenting incidence rates of HCV and specifying HIV status were included.
  
  
  METHODS
  Data were abstracted by two authors using predefined data fields. The STROBE checklist was used to assess study quality.
  
  
  RESULTS
  Data were divided into HIV-negative MSM and HIV-positive MSM subgroups, and HCV incidence density measurements were pooled. Using a DerSimonian-Laird random effects model, pooled incidence was 1.48/1000 person-years (95% CI 0.75 to 2.21) for the HIV-negative MSM subgroup. The HIV-positive MSM subgroup was at 4.1 times higher risk of acquiring HCV at 6.08/1000 person-years (95% CI 5.18 to 6.99). Studies directly comparing subgroups estimated a pooled risk difference of 3.45/1000 person-years (95% CI 1.63 to 5.27).
  
  
  CONCLUSIONS
  HIV-positive MSM were at higher risk for acute HCV infection than HIV-negative MSM, substantiating the need for routine screening initiatives. Insufficient evidence exists to warrant routine screening of HIV-negative MSM, except on a case-by-case basis, such as high-risk sexual behaviour.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Chronic Viral Illness Service, Montreal Chest Institute, 3650 Saint Urbain, Montreal, Quebec H2X 2P4, Canada.
authors.forename: Sean
authors.initials: S
authors.lastname: Yaphe
authors.forename: Nikki
authors.initials: N
authors.lastname: Bozinoff
authors.forename: Rachel
authors.initials: R
authors.lastname: Kyle
authors.forename: Sushmita
authors.initials: S
authors.lastname: Shivkumar
authors.forename: Nitika Pant
authors.initials: NP
authors.lastname: Pai
authors.forename: Marina
authors.initials: M
authors.lastname: Klein
mesh_terms: D060085:Coinfection / Q000453:epidemiology*; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000453:epidemiology*; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D018570:Risk Assessment