title: Effect of sow and piglet porcine circovirus type 2 (PCV2) vaccination on piglet mortality, viraemia, antibody titre and production parameters.
abstract: The present study describes the effects of sow and/or piglet porcine circovirus type 2 (PCV2) vaccination on viraemia, antibody response and production parameters (average daily weight gain [ADWG] and mortality) of piglets from a PCV2 subclinically infected farm. Four hundred seventy-six piglets born from vaccinated (V) or non-vaccinated (NV) sows were further subdivided in a total of four groups: NV sows-NV pigs (NV-NV, n=134), NV sows-V pigs (NV-V, n=135);V sows-NV pigs (V-NV, n=104) and V sows-V pigs (V-V, n=103). A single vaccination of sows before mating was able to confer significantly higher antibody titres to their piglets at 4 weeks of age and a different PCV2 dynamics infection compared to piglets coming from NV sows. Piglet vaccination (independently of sow treatment) caused an earlier seroconversion and lower percentages of PCV2 infected pigs compared to the NV ones throughout their life. The double PCV2 vaccination strategy was able to reduce PCV2 infection but apparently caused some interference in piglet humoral response development. PCV2 vaccination was able to overcome this interference since the ADWG was improved in both groups of vaccinated piglets, independently of the sow treatment, being the highest ones obtained in the double vaccination group.
authors.affiliation: Centre de Recerca en Sanitat Animal, UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fraile
authors.forename: Marina
authors.initials: M
authors.lastname: Sibila
authors.forename: Miquel
authors.initials: M
authors.lastname: Nofrarías
authors.forename: Rosa
authors.initials: R
authors.lastname: López-Jimenez
authors.forename: Eva
authors.initials: E
authors.lastname: Huerta
authors.forename: Anna
authors.initials: A
authors.lastname: Llorens
authors.forename: Sergio
authors.initials: S
authors.lastname: López-Soria
authors.forename: Diego
authors.initials: D
authors.lastname: Pérez
authors.forename: Joaquim
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D018173:Circoviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000401:mortality / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000276:immunology*; D005260:Female; D016014:Linear Models; D016133:Polymerase Chain Reaction; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality* / Q000821:virology; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology; D014766:Viremia / Q000175:diagnosis / Q000276:immunology / Q000401:mortality / Q000662:veterinary* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines