title: Biomaterials immobilized with chitosan for rechargeable antimicrobial drug delivery.
abstract: Microbial contamination on medical device material surfaces causes serious problems including device-related infections. Here we report a new strategy to produce rechargeable antimicrobial biomaterial surfaces to address the issue. Methacrylic acid (MAA) was grafted onto the surfaces of polyurethane (PU), a widely used biomaterial with excellent biological and mechanical properties. Chitosan was covalently bonded onto the MAA-grafted surfaces. The new chitosan-containing PU strongly bound and then slowed release anionic antibiotics (e.g., rifampin) for weeks to months to kill microbes. The released drug could be recharged with the same or a different class of drugs to further extend antimicrobial duration. Also, the new surfaces demonstrated good biocompatibility against mammal cells, pointing to great potentials for a wide range of biomedical applications.
authors.affiliation: Department of Biomedical Engineering, University of South Dakota, Sioux Falls, South Dakota 57107, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D016503:Drug Delivery Systems; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D008567:Membranes, Artificial; D008826:Microbial Sensitivity Tests; D010126:Ozone / Q000494:pharmacology; D011140:Polyurethanes / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000494:pharmacology; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011140:Polyurethanes; D002939:Ciprofloxacin; D010126:Ozone; D048271:Chitosan; D012293:Rifampin