title: Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology.
abstract: OBJECTIVE
  To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis.
  
  
  METHODS
  Fifty-six consecutive PCa patients underwent real-time elastography examination with a bi-plane transducer before RP. Transverse elastographic images were obtained from the apex to the base by slightly compressing and releasing the prostate tissue using the probe. The diagnostic performance of elastography was evaluated in correlation with step section RP histopathology.
  
  
  RESULTS
  In 56 PCa patients, gray-scale ultrasonography detected at least one lesion in 36 patients, whereas elastography detected at least one lesion in 53 patients (P = 0.001). The overall sensitivity, specificity and accuracy of elastography in depicting tumor lesions were 67.6, 89.5 and 82.7 %, respectively. The detection rate of a PCa lesion with elastography was best in the left posterior region, followed by the right posterior region. Elastography was more sensitive in detecting PCa lesions with higher Gleason scores, diameter >5 mm and extracapsular extension.
  
  
  CONCLUSIONS
  The additional use of elastography with the bi-plane transducer can improve PCa detection rate by providing more information about tissue stiffness within the prostate gland.
authors.affiliation: Department of Ultrasound in Medicine, Xinhua Hospital Affiliated to Shanghai, Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People's Republic of China.
authors.forename: Yunkai
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Chen
authors.forename: Tingyue
authors.initials: T
authors.lastname: Qi
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Yongjiang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yao
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D015331:Cohort Studies; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014159:Transducers