title: Permanent polymer coating for in vivo MRI visualization of tissue reinforcement prostheses.
abstract: The clinical advantage of MRI visualization of prostheses in soft tissue prolapses is very appealing as over 1,000000 MRI-transparent synthetic meshes are implanted annually, and postoperative complications such as mesh shrinkage and migration are frequent. Here, the synthesis of a new material composed of a DTPA-Gd complex grafted onto a backbone of PMA via a covalent bond is described (DTPA-Gd-PMA). This new polymer is sprayed onto meshes and gives an MR signal for a long period without any significant release of Gd. In vitro cytocompatibility tests on fibroblasts show limited cytotoxicity. Microscopic investigations indicate that vital cells rapidly colonize the material. Finally, coated meshes implanted in rats are easily recognizable using an MR imaging system.
authors.affiliation: Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier 34093, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Guillaume
authors.forename: Sébastien
authors.initials: S
authors.lastname: Blanquer
authors.forename: Vincent
authors.initials: V
authors.lastname: Letouzey
authors.forename: Arnaud
authors.initials: A
authors.lastname: Cornille
authors.forename: Stephanie
authors.initials: S
authors.lastname: Huberlant
authors.forename: Laurent
authors.initials: L
authors.lastname: Lemaire
authors.forename: Florence
authors.initials: F
authors.lastname: Franconi
authors.forename: Renaud
authors.initials: R
authors.lastname: de Tayrac
authors.forename: Jean
authors.initials: J
authors.lastname: Coudane
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D019786:Gadolinium DTPA / Q000737:chemistry* / Q000494:pharmacology; D015850:Interleukin-6 / Q000096:biosynthesis; D008279:Magnetic Resonance Imaging; D051379:Mice; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D015850:Interleukin-6; D019904:Polymethyl Methacrylate; D019786:Gadolinium DTPA