title: Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients.
abstract: OBJECTIVE
  This study aimed to evaluate the prevalence of low bone mineral density (BMD) in recently diagnosed adult celiac patients and to identify the factors associated with this.
  
  
  METHODS
  We investigated 54 newly diagnosed adult celiac patients between February 2008 and April 2009. BMD was measured in all patients and its correlation with clinical and biochemical parameters was analyzed.
  
  
  RESULTS
  Fifty-four (24 male) newly diagnosed celiac patients with a mean±SD age of 30.6 ± 9.3 years (range 18-50) were included. Thirty-nine (72.2 %) presented with intestinal symptoms, and the rest with extraintestinal symptoms. Low vitamin D levels were seen in 11 (20.3 %) patients and elevated iPTH (secondary hyperparathyroidism) in 12 (22.2 %) patients. Twenty-one (39 %) patients had normal BMD, 23 (43 %) had osteopenia (T-score -1 to -2.5), and 10 (18 %) patients had osteoporosis (T-score <-2.5). A statistically significant association was seen between BMD and age of onset, duration of illness, serum tTGA levels, serum vitamin D levels, and histopathological changes.
  
  
  CONCLUSIONS
  Low BMD is common in newly diagnosed adult celiac patients with approximately one fifth of them having osteoporosis. BMD should be measured in all newly diagnosed celiac patients and calcium and vitamin D supplementation included in the treatment regimen.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
authors.forename: Sudheer D
authors.initials: SD
authors.lastname: Chakravarthi
authors.forename: Kapil
authors.initials: K
authors.lastname: Jain
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kochhar
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Bhadada
authors.forename: Niranjan
authors.initials: N
authors.lastname: Khandelwal
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.forename: Usha
authors.initials: U
authors.lastname: Dutta
authors.forename: Chander K
authors.initials: CK
authors.lastname: Nain
authors.forename: Kartar
authors.initials: K
authors.lastname: Singh
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002446:Celiac Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000097:blood; D015995:Prevalence; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D