title: Detection of antiphospholipid antibody in children with Henoch-Schönlein purpura and central nervous system involvement.
abstract: To explore the mechanisms of central nervous system involvement in children with Henoch-Schönlein purpura, levels of lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein I antibodies in serum and cerebrospinal fluid were determined in 46 cases of Henoch-Schönlein purpura with central nervous system involvement. Results indicated that Henoch-Schönlein purpura with central nervous system involvement produced a higher total percentage of antiphospholipid antibodies in serum and cerebrospinal fluid, compared with viral encephalitis control subjects (76.1% vs 10.0% and 71.7% vs 0.0%, respectively; P < 0.05). Henoch-Schönlein purpura may be associated with antiphospholipid syndrome or antiphospholipid antibodies, which may account for the neurologic damage in Henoch-Schönlein purpura.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China; Department of Pediatrics, First People's Hospital of Yunnan Province, Kunming, China.
authors.forename: Ailin
authors.initials: A
authors.lastname: Liu
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhang
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000134:cerebrospinal fluid; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000134:cerebrospinal fluid; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000276:immunology*; D016682:Lupus Coagulation Inhibitor / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I