title: Statin use and risk of prostate cancer in the prospective Osteoporotic Fractures in Men (MrOS) Study.
abstract: BACKGROUND
  Statins are a common medication for cholesterol control that may also have effects on cancer-related pathways. The evidence of an association between statins and prostate cancer risk remains ambiguous.
  
  
  METHODS
  We examined statin use in a prospective cohort of 5,069 elderly U.S. men and the risk of incident total, low/high stage, and low/high grade prostate cancer diagnosed between 2000 and 2008. We used multivariate logistic regression models to estimate relative risks and 95% confidence intervals, adjusting for demographic and lifestyle characteristics.
  
  
  RESULTS
  There was no evidence of an association between statin use and any of the prostate cancer endpoints (total, low/high stage, low/high grade prostate cancer), adjusting for age, study site, race, body mass index, marital status, family history of prostate cancer, number of comorbidities, physical activity, and smoking history.
  
  
  CONCLUSIONS
  In this study of elderly U.S. men, we observed a null association between statin use and risk of prostate cancer.
authors.affiliation: Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California 94158-9001, USA. june.chan@ucsf.edu
authors.forename: June M
authors.initials: JM
authors.lastname: Chan
authors.forename: Stephanie
authors.initials: S
authors.lastname: Litwack-Harrison
authors.forename: Scott R
authors.initials: SR
authors.lastname: Bauer
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Daniels
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Wilt
authors.forename: Jackilen
authors.initials: J
authors.lastname: Shannon
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Bauer
mesh_terms: D000368:Aged; D015331:Cohort Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000139:chemically induced*; D012306:Risk
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors