title: Sensitization and allergic histories differ between black and white pregnant women.
abstract: BACKGROUND
  Racial differences in allergic diseases have been reported, with black subjects suffering disproportionately compared with white subjects, although such studies have been more commonly done in pediatric populations.
  
  
  OBJECTIVE
  We sought to determine whether there are differences in rates of allergic sensitization or prior diagnoses of asthma, hay fever, or eczema in black and white pregnant women.
  
  
  METHODS
  Women were recruited during pregnancy (regardless of allergic history) as part of a birth cohort study in the Detroit metropolitan area and were interviewed about prior doctors' diagnoses of asthma, hay fever/nasal allergies/allergic rhinitis, and eczema. Blood samples were collected, total IgE levels were determined, and specific IgE levels were measured for Alternaria alternata, cat, cockroach, dog, Dermatophagoides farinae, short ragweed, timothy grass, and egg.
  
  
  RESULTS
  Black women (n = 563) were more likely than white women (n = 219) to have had at least 1 specific IgE level of 0.35 IU/mL or greater (62.5% vs 40.2%, P < .001). Black women had higher total IgE levels (geometric mean, 47.8 IU/mL [95% CI, 42.5-53.8 IU/mL] vs 20.0 IU/mL [95% CI, 16.2-24.6 IU/mL]; P < .001, Wilcoxon rank sum test). Black women were more likely to have had a prior doctor's diagnosis of asthma (22.7% vs 16.0%, P = .04) and eczema (21.9% vs 14.8%) but not hay fever (white women: 17.5% vs black women: 15.7%, P = .55). Associations persisted for total IgE levels, having 1 or more positive allergen-specific IgE levels, and eczema after adjusting for common socioeconomic or environmental variables.
  
  
  CONCLUSIONS
  Racial differences in allergic sensitization and diagnoses were present, even after controlling for various factors. Future research should focus on prevention to ameliorate these disparities.
authors.affiliation: Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI 48202, USA. gwegien1@hfhs.org
authors.forename: Ganesa
authors.initials: G
authors.lastname: Wegienka
authors.forename: Christine L M
authors.initials: CL
authors.lastname: Joseph
authors.forename: Suzanne
authors.initials: S
authors.lastname: Havstad
authors.forename: Edward
authors.initials: E
authors.lastname: Zoratti
authors.forename: Dennis
authors.initials: D
authors.lastname: Ownby
authors.forename: Christine Cole
authors.initials: CC
authors.lastname: Johnson
mesh_terms: D000328:Adult; D044383:Black People; D015331:Cohort Studies; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D006967:Hypersensitivity / Q000208:ethnology*; D007073:Immunoglobulin E / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000208:ethnology*; D044465:White People
chemical_list: D007073:Immunoglobulin E