title: Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung.
abstract: BACKGROUND
  Pulmonary squamous cell carcinoma has a poor prognosis, and new therapeutic targets are needed. The aberrant expression of the immunomodulatory proteins B7-H1 and B7-H3 by malignant cells may contribute to tumoral immune evasion. Data about the expression of these proteins by squamous cell carcinoma of the lung are limited.
  
  
  METHODS
  Immunohistochemistry for B7-H1 and B7-H3 was performed on 214 resected pulmonary squamous cell carcinoma specimens.
  
  
  RESULTS
  At the last follow-up, 171 of 214 (80%) of patients were deceased (median survival time, 3.76 years). Forty-two (19.6%) of 214 cases showed positivity with B7-H1, with a range of 5% to 60% of cells that stained positively. A total of 189 (88.3%) of 214 cases showed positivity with B7-H3, with a range of 5% to 80% of cells staining positively. By using multivariate analysis, no degree of B7-H1 or B7-H3 positivity was significantly associated with patient outcome.
  
  
  CONCLUSIONS
  Although B7-H1 and B7-H3 are not of independent prognostic value, they are commonly expressed on a subset of tumor cells in pulmonary squamous cell carcinomas. Known interaction of the B7-H proteins with cytotoxic T-lymphocyte antigen-4 may make them attractive candidate biomarkers for response to immunomodulatory therapeutics, eg, ipilimumab, and warrants further study.
authors.affiliation: Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Boland
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Kwon
authors.forename: Susan M
authors.initials: SM
authors.lastname: Harrington
authors.forename: Jason A
authors.initials: JA
authors.lastname: Wampfler
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Aubry
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060887:B7 Antigens / Q000032:analysis*; D060890:B7-H1 Antigen / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D060887:B7 Antigens; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C423237:CD276 protein, human