title: Zygomycosis over-infection during voriconazole therapy for aspergillosis in a heart transplant patient, successfully treated with liposomal amphotericin and posaconazole.
abstract: Aspergillosis and zygomycosis are life-threatening fungal infections in immunocompromised patients. We report a heart transplant recipient with an early pulmonary invasive aspergillosis successfully treated with association of voriconazole and caspofungin. Zygomycosis sinusitis, which was diagnosed while he still was on voriconazole therapy, was successfully treated with the use of combination antifungal therapy including liposomal amphotericin plus posaconazole and conservative surgical debridement.
authors.affiliation: Division de Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Bourke
authors.forename: P
authors.initials: P
authors.lastname: Castro
authors.forename: R
authors.initials: R
authors.lastname: Rabagliati
authors.forename: C
authors.initials: C
authors.lastname: Beltran
authors.forename: H
authors.initials: H
authors.lastname: Verdejo
authors.forename: J L
authors.initials: JL
authors.lastname: Winter
authors.forename: R C
authors.initials: RC
authors.lastname: Bourge
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003646:Debridement; D004359:Drug Therapy, Combination; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines; D012852:Sinusitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole; D020096:Zygomycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B; D065819:Voriconazole