title: Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D).
  
  
  METHODS
  A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA).
  
  
  RESULTS
  Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10(-6)), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10(-7)) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10(-8); OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10(-8), respectively).
  
  
  CONCLUSIONS
  This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Republic of Korea.
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
authors.forename: Sung Jae
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Ji
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
mesh_terms: D044466:Asian People / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins