title: Practical way to imidazo[4,5-b] and [4,5-c]pyridine-2-ones via cascade ureidation/palladium-catalyzed cyclization.
abstract: We developed an efficient one-pot tandem carbamoyl chloride amination and palladium-catalyzed intramolecular urea cyclization, which furnished high-throughput access to imidazo[4,5-b]pyridine-2-one and related imidazo[4,5-c]pyridine-2-one ring systems. Moderate to excellent yields were reported.
authors.affiliation: AstraZeneca , Centre de Recherches, Z.I. la Pompelle, BP1050, 51689 Reims Cedex.
authors.forename: Franck
authors.initials: F
authors.lastname: Lach
authors.forename: Patrice
authors.initials: P
authors.lastname: Koza
mesh_terms: D000586:Amination; D002384:Catalysis; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D014508:Urea / Q000737:chemistry
chemical_list: D007093:Imidazoles; D011725:Pyridines; D010165:Palladium; D014508:Urea; C023666:pyridine