title: Anchoring proteins as regulators of signaling pathways.
abstract: Spatial and temporal organization of signal transduction is coordinated through the segregation of signaling enzymes in selected cellular compartments. This highly evolved regulatory mechanism ensures the activation of selected enzymes only in the vicinity of their target proteins. In this context, cAMP-responsive triggering of protein kinase A is modulated by a family of scaffold proteins referred to as A-kinase anchoring proteins. A-kinase anchoring proteins form the core of multiprotein complexes and enable simultaneous but segregated cAMP signaling events to occur in defined cellular compartments. In this review we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac physiopathology.
authors.affiliation: Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Perino
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ghigo
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D054758:A Kinase Anchor Proteins / Q000378:metabolism*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000201:enzymology / Q000503:physiopathology; D006332:Cardiomegaly / Q000201:enzymology / Q000503:physiopathology; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004789:Enzyme Activation; D006333:Heart Failure / Q000201:enzymology / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D046912:Multiprotein Complexes; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology*; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D054758:A Kinase Anchor Proteins; D046912:Multiprotein Complexes; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases