title: Incidence and prognosis of intra-abdominal hypertension in critically ill medical patients: a prospective epidemiological study.
abstract: BACKGROUND
  The aim of this study was to determine the incidence of intra-abdominal hypertension (IAH) in patients with two or more categorized risk factors (CRF) for IAH, and their morbidity and mortality during their intensive care unit (ICU) stay.
  
  
  METHODS
  Prospective cohort study carried out at a medical ICU. A total of 151 medical patients were enrolled during a period of 3 months. After ICU whole staff training, we conducted daily screening of the four CRF for IAH based on the World Society of Abdominal Compartment Syndrome (WSACS) guidelines (namely, diminished abdominal wall compliance, increased intraluminal content, increased abdominal content, and capillary leak syndrome or fluid resuscitation). In those patients with risk factors of at least two different categories (≥2 CRF), intra-abdominal pressure (IAP) was measured every 8 h during ICU stay. Data included demographics, main diagnosis on admission, severity scores, cumulative fluid balance, daily mean IAP, resolution of IAH, days of ICU and hospital stay, and mortality.
  
  
  RESULTS
  Eighty-seven patients (57.6%) had ≥2 CRF for IAH, 59 (67.8%) out of whom developed IAH. Patients with ≥2 CRF had a significantly higher mortality rate (41.4 vs. 14.3%, p < 0.001). Patients with IAH had higher body mass index, severity scores, organ dysfunctions/failures, number of CRF for IAH, days of ICU/hospital stay and hospital mortality rate (45.8 vs. 32.1%, p = 0.22). Non-resolution of IAH was associated with a higher mortality rate (64.7 vs. 35.3%, p = 0.001). None of the cohort patients developed abdominal compartment syndrome. The multivariate analysis showed that IAH development (odds ratio (OR) 4.09; 95% confidence interval (CI) 0.83-20.12) was a non-independent risk factor for mortality, and its non-resolution (OR 13.15; 95% CI 22.13-81.92) was an independent risk factor for mortality.
  
  
  CONCLUSIONS
  Critically ill medical patients admitted to ICU with ≥2 CRF have high morbidity, mortality rate, and incidence of IAH, so IAP should be measured and monitored as recommended by the WSACS. Our study highlights the importance of implementing screening and assessment protocols for an early diagnosis of IAH.
authors.affiliation: Intensive Care Unit, Hospital General Universitario Gregorio Marañón, Calle Doctor Esquerdo 46, Madrid, 28007, Spain. patriciasantateresa@hotmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Santa-Teresa
authors.forename: Javier
authors.initials: J
authors.lastname: Muñoz
authors.forename: Ignacio
authors.initials: I
authors.lastname: Montero
authors.forename: María
authors.initials: M
authors.lastname: Zurita
authors.forename: María
authors.initials: M
authors.lastname: Tomey
authors.forename: Luis
authors.initials: L
authors.lastname: Alvarez-Sala
authors.forename: Pablo
authors.initials: P
authors.lastname: García