title: A traditional Chinese herbal medicine compound preparation versus interventional therapy after resection of small hepatocellular carcinoma: 22-year follow-up.
abstract: OBJECTIVE
  To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy (IT) in patients after resection of small hepatocellular carcinoma (HCC). in 399 patients after resection of small HCC who were admitted between January 1987 and December 2008 in the Department of Hepatobiliary Surgery and Center of Minimally Invasive Surgery, First Affiliated Hospital of Guangxi Medical University. Four groups were based on different therapy modes: a TCM-only (TCMO) group, a TCM combined with interventional therapy (TCM-IT) group, an interventional therapy-only (ITO) group, and a simple operation (SO) group. Prognostic factors were correlated with overall survival (OS) and OS rates were calculated with the Kaplan-Meier method, and multivariate analyses for factors affecting survival were evaluated by the Cox proportional hazard model.
  
  
  RESULTS
  The median OS was 151.20 months in the TCM-IT group, 43.87 months in the ITO group, and 20.77 months in the SO group. All survival rates of the TCMO group were higher than those of the other three groups (>50%). The 5-, 10-, and 15-year OS in the TCMO and ITO patients were 83.94%, 45.50%, and 71.22% and 33.34%, 55.58%, and 9.26%, respectively (risk ratio, 0.209; 95% confidence interval, 0.126-0.347; P = 0.000). Multivariate analysis revealed that the independent risk factors were therapy mode (P = 0.000), sex (P = 0.005), family history (P = 0.011), TNM classification of malignant tumor staging (P = 0.000), medical care-seeking behavior (P = 0.021), and maximum diameter (P = 0.030).
  
  
  CONCLUSIONS
  Long-term oral use of compound RJH tablets may improve OS for small HCC after resection compared with IT.
authors.affiliation: Department of Sanitarium Area, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 211131, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Sun
authors.forename: Shui-ting
authors.initials: ST
authors.lastname: Liang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zhai
authors.forename: Qing-bo
authors.initials: QB
authors.lastname: Lang
authors.forename: Qing-hui
authors.initials: QH
authors.lastname: Zhou
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Yue
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Chang-quan
authors.initials: CQ
authors.lastname: Ling
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D004365:Drugs, Chinese Herbal