title: A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats.
abstract: Achieving an appropriate DHA status in the neonatal brain is an important goal of neonatal nutrition. We evaluated how alpha-linolenic acid (ALA), provided for six weeks after weaning by different dietary fat matrix, improved brain DHA content of young male rats born from deficient-dams. The level of ALA achieved was based on the fat composition of usual infant vegetable formula. A palm oil-blend diet thus providing 1.5%ALA was compared to dairy fat-blend-based diets that provided either 1.5%ALA or 2.3%ALA, or a rapeseed oil diet providing 8.3%ALA (n-6/n-3 ratio were, respectively 10,10,5,2.5). The 1.5%ALA-dairy-fat-blend was superior to 1.5%ALA-palm-oil-blend to restore values of brain DHA, while the 2.3%ALA-dairy-fat-blend exhibited a further increase and reached the values obtained with pure rapeseed diet (8.3%ALA). Dairy-fat-blends enriched with ALA appear to be an interesting strategy for achieving optimal DHA levels in the brain of post-weaning rats. Providing dairy fat as well as a reduction of the LA/ALA ratio should be reconsidered to design infant formula.
authors.affiliation: UMR 8195 CNPS-Centre de Neurosciences Paris-Sud, NMPA-Neuroendocrinologie Moléculaire de la Prise Alimentaire, Université Paris-Sud XI, Orsay F-91405, France. bernadette.delplanque@u-psud.fr
authors.forename: B
authors.initials: B
authors.lastname: Delplanque
authors.forename: Q
authors.initials: Q
authors.lastname: Du
authors.forename: G
authors.initials: G
authors.lastname: Agnani
authors.forename: P
authors.initials: P
authors.lastname: Le Ruyet
authors.forename: J C
authors.initials: JC
authors.lastname: Martin
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003611:Dairy Products; D004041:Dietary Fats / Q000378:metabolism*; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D005527:Food, Fortified / Q000032:analysis; D006017:Glycolipids / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry / Q000378:metabolism; D066292:Lipid Droplets; D008297:Male; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism; D009752:Nutritional Status; D010938:Plant Oils / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation; D014886:Weaning; D017962:alpha-Linolenic Acid / Q000008:administration & dosage* / Q000172:deficiency / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D004041:Dietary Fats; D006017:Glycolipids; D006023:Glycoproteins; D010938:Plant Oils; C110367:milk fat globule; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids