title: Expression profile of extracellular matrix and adhesion molecules in the development of endometriosis in a mouse model.
abstract: Ectopic endometrial tissue induces various reactions in surrounding tissues, such as the surface of the ovary and peritoneal cavity, leading to endometriosis. The aim of this study is to investigate the expression profile of extracellular matrix (ECM) and adhesion molecules in the early steps of development of experimental mouse endometriosis, specifically in peritoneum adjacent to endometrium transplants attached via autotransplantation. The endometriosis model was induced by autotransplantation of endometrium to peritoneal tissue. Peritoneal tissues adjacent to the transplant were obtained at 1, 4, and 7 days posttransplantation. The results showed that messenger RNA expression levels of most of the integrins, collagens, and other ECM reached a peak at 7 days posttransplantation. Uniquely, Lamc2 was significantly increased to its maximum level within 24 hours posttransplantation and may be strongly associated with initiation of the development of endometriosis. These data will be helpful in further investigations of the treatment of endometriosis.
authors.affiliation: Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi, Japan. masa-ume@rs.noda.tus.ac.jp
authors.forename: Masakazu
authors.initials: M
authors.lastname: Umezawa
authors.forename: Yumi
authors.initials: Y
authors.lastname: Saito
authors.forename: Naomi
authors.initials: N
authors.lastname: Tanaka-Hattori
authors.forename: Ken
authors.initials: K
authors.lastname: Takeda
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ihara
authors.forename: Masao
authors.initials: M
authors.lastname: Sugamata
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics*; D004195:Disease Models, Animal; D004715:Endometriosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D016023:Integrins / Q000235:genetics; D051379:Mice; D008813:Mice, Inbred ICR; D010537:Peritoneum; D012333:RNA, Messenger / Q000032:analysis; D014599:Uterus / Q000637:transplantation
chemical_list: D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins; D012333:RNA, Messenger