title: NF-κB signaling pathway and free radical impact.
abstract: The activation of NF-κB transcription factor is critical for a wide range of processes such as immunity, inflammation, cell development, growth and survival. It is activated by a variety of stimuli including cytokines, ionizing radiation and oxidative stress. Redox modulations of NF-κB pathway have been widely demonstrated. Studies carried out during last years have advanced our knowledge about possible connections between NF-κB pathway and the impact of free radicals. This review is an endeavor to gather recent results focused on this issue, although an important question, whether oxidative stress plays a physiological role in NF-κB activation, seems to be still unanswered.
authors.affiliation: Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Department of Clinical Biochemistry, Poland. asiomek@cm.umk.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Siomek
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism; D002470:Cell Survival; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress; D010766:Phosphorylation; D025941:Protein Interaction Mapping; D059748:Proteolysis; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016328:NF-kappa B; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D051550:I-kappa B Kinase