title: Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery.
abstract: Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.
authors.affiliation: Traumatic Brain Injury Research Laboratory, Kessler Foundation Research Center, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA, sweaver@kesslerfoundation.org.
authors.forename: Starla M
authors.initials: SM
authors.lastname: Weaver
authors.forename: Jaclyn N
authors.initials: JN
authors.lastname: Portelli
authors.forename: Aileen
authors.initials: A
authors.lastname: Chau
authors.forename: Irene
authors.initials: I
authors.lastname: Cristofori
authors.forename: Laura
authors.initials: L
authors.lastname: Moretti
authors.forename: Jordan
authors.initials: J
authors.lastname: Grafman
mesh_terms: D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D020127:Recovery of Function / Q000235:genetics*