title: [Myocardial signs of cardiotoxicity].
abstract: The myocardium have been get from 70 died patients suffered from schizophrenia and treated by neuroleptic drugs. The cardiotoxic effect of neuroleptic drugs was characterized as adaptive, degenerative, and fibrous changes in the miocardium. In the extracellular matrix of the myocardium the processes of microcirculation and the collagenogenesis were damaged. As a result of the using neuroleptic drugs a compensatory hypertrophy of cardiomyocytes was transformed into their degeneration and atrophy that could be reason of a heart failure.
authors.forename: V P
authors.initials: VP
authors.lastname: Volkov
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D054715:Cardiotoxins / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005109:Extracellular Matrix / Q000648:ultrastructure; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000648:ultrastructure*; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology
chemical_list: D014150:Antipsychotic Agents; D054715:Cardiotoxins