title: Fasting and postprandial activity of brown adipose tissue in healthy men.
abstract: The role of brown adipose tissue (BAT) in adult metabolism is poorly understood. This study aimed to examine the differential effects of an overnight fast and the postprandial state on BAT activity.
  
  
  METHODS
  We included 10 healthy, lean male volunteers. BAT uptake of glucose was visualized using (18)F-FDG PET/CT during mild cold exposure. Each subject underwent PET/CT twice. The first scan was obtained after an overnight fast; the second after a standardized meal.
  
  
  RESULTS
  (18)F-FDG uptake in BAT was observed in 6 of 10 volunteers. These subjects were found to have a higher maximal standardized uptake value when fasting (median, 13.1 g/mL; range, 6.1-27.6 g/mL) than when in the postprandial state (median, 6.8 g/mL; range, 2.1-13.4 g/mL) (P = 0.03).
  
  
  CONCLUSIONS
  Cold-stimulated (18)F-FDG uptake by BAT in humans is more pronounced during fasting. The lower maximal standardized uptake value in the postprandial state may be explained by increased insulin-stimulated glucose uptake in muscle.
authors.affiliation: Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands. a.vrieze@amc.uva.nl
authors.forename: Anne
authors.initials: A
authors.lastname: Vrieze
authors.forename: Josefine E
authors.initials: JE
authors.lastname: Schopman
authors.forename: Wanda M
authors.initials: WM
authors.lastname: Admiraal
authors.forename: Maarten R
authors.initials: MR
authors.lastname: Soeters
authors.forename: Max
authors.initials: M
authors.lastname: Nieuwdorp
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Verberne
authors.forename: Frits
authors.initials: F
authors.lastname: Holleman
mesh_terms: D052437:Adipocytes, Brown / Q000000981:diagnostic imaging / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D003080:Cold Temperature; D005215:Fasting / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006262:Health; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019518:Postprandial Period; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose