title: Rectal lymphoma in 11 dogs: a retrospective study.
abstract: OBJECTIVE
  To retrospectively evaluate the clinical behaviour and immunophenotype of lymphoma of the rectum in dogs.
  
  
  METHODS
  Eleven dogs diagnosed with lymphoma of the rectum on histopathology were retrospectively reviewed. Immunohistochemistry with CD3 and CD79a antibodies was performed at diagnosis or retrospectively.
  
  
  RESULTS
  Treatment protocol varied with six dogs undergoing surgery and adjuvant chemotherapy, two received chemotherapy after only incisional biopsy, one had surgical resection only, one was treated symptomatically and one dog was not treated. Chemotherapy treatment consisted of either a -low-dose COP (cyclophosphamide - prednisolone - vincristine) protocol (four dogs) or a six-week CHOP-based (cyclophosphamide - vincristine - -prednisolone - anthracycline) protocol (four dogs). Dogs that received chemotherapy lived significantly longer than dogs that did not receive chemotherapy (2352 versus 70 days). Median survival time was not reached, and there was an overall mean survival time of 1697 days. Immunohistochemistry was performed in 10 of 11 samples, and was consistent with B-cell -lymphoma in all cases.
  
  
  CONCLUSIONS
  Canine lymphoma of the rectum is associated with a favourable prognosis. Immunohistochemical evaluation of these lesions was consistent with B-cell lymphoma in all cases in which it was examined.
authors.affiliation: Centre for Small Animal Studies, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk.
authors.forename: N
authors.initials: N
authors.lastname: Van den Steen
authors.forename: D
authors.initials: D
authors.lastname: Berlato
authors.forename: G
authors.initials: G
authors.lastname: Polton
authors.forename: J
authors.initials: J
authors.lastname: Dobson
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: G
authors.initials: G
authors.lastname: Maglennon
authors.forename: A M
authors.initials: AM
authors.lastname: Hayes
authors.forename: S
authors.initials: S
authors.lastname: Murphy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents