title: Atropine sulphate: rescue therapy for pyloric stenosis.
abstract: Infantile hypertrophic pyloric stenosis (IHPS) is a common condition which presents with non-bilious vomiting and failure to thrive secondary to gastric outlet obstruction. In the UK, management is by fluid resuscitation followed by pyloromyotomy. Incomplete myotomy complicates 0.3% of cases necessitating further surgery and exposing the patient to further risk. Medical management of IHPS with antimuscarinics to promote pyloric relaxation is a well-described treatment modality that is used as first-line therapy in some countries. The use of this technique is limited by the need for extended hospital admission with parenteral nutrition administration. We describe a case of IHPS complicated by incomplete pyloromyotomy and subsequently managed successfully by atropine sulphate therapy.
authors.affiliation: Department of General Surgery, Arrowe Park Hospital, Liverpool, UK. richowen83@hotmail.com
authors.forename: Richard Peter
authors.initials: RP
authors.lastname: Owen
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Almond
authors.forename: Gill M E
authors.initials: GM
authors.lastname: Humphrey
mesh_terms: D001285:Atropine / Q000627:therapeutic use*; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D010288:Parenteral Nutrition / Q000379:methods; D011707:Pyloric Stenosis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology; D015431:Weight Loss
chemical_list: D018727:Muscarinic Antagonists; D001285:Atropine