title: Blend uniformity analysis of pharmaceutical products by Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS).
abstract: Blend uniformity analysis (BUA) is a routine and highly regulated aspect of pharmaceutical production. In most instances, it involves quantitative determination of individual components of a blend in order to ascertain the mixture ratio. This approach often entails the use of costly and sophisticated instrumentation and complex statistical methods. In this study, a new and simple qualitative blend confirmatory test is introduced based on a well known acoustic phenomenon. Several over the counter (OTC) product powder blends are analysed and it is shown that each product has a unique and highly reproducible acoustic signature. The acoustic frequency responses generated during the dissolution of the product are measured and recorded in real time. It is shown that intra-batch and inter-batch variation for each product is either insignificant or non-existent when measured in triplicate. This study demonstrates that Broadband Acoustic Resonance Dissolution Spectroscopy or BARDS can be used successfully to determine inter-batch variability, stability and uniformity of powder blends. This is just one application of a wide range of BARDS applications which are more cost effective and time efficient than current methods.
authors.affiliation: Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Ireland. d.fitzpatrick@ucc.ie
authors.forename: Dara
authors.initials: D
authors.lastname: Fitzpatrick
authors.forename: Eoin
authors.initials: E
authors.lastname: Scanlon
authors.forename: Jacob
authors.initials: J
authors.lastname: Krüse
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Vos
authors.forename: Rachel
authors.initials: R
authors.lastname: Evans-Hurson
authors.forename: Eileen
authors.initials: E
authors.lastname: Fitzpatrick
authors.forename: Seán
authors.initials: S
authors.lastname: McSweeney
mesh_terms: D000162:Acoustics; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000592:standards; D011208:Powders / Q000737:chemistry* / Q000592:standards; D011786:Quality Control; D013057:Spectrum Analysis / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders