title: Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis.
abstract: BACKGROUND
  Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state.
  
  
  METHODS
  Adult patients with CF were studied immediately preceding and following 2 weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured.
  
  
  RESULTS
  Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01).
  
  
  CONCLUSIONS
  The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.
authors.affiliation: Centre for Clinical Pharmacology, Division of Biomedical Sciences, St George's, University of London, Cranmer Terrace, London. SW17 0RE, UK. Electronic address: jiminio@doctors.org.uk.
authors.forename: James H
authors.initials: JH
authors.lastname: Hull
authors.affiliation: Dept. of Physiotherapy, Kings College Hospital NHS Foundation Trust, Dulwich Hospital, London, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Garrod
authors.affiliation: Frimley Park Hospital NHS Foundation Trust, Frimley, Surrey, GU16 7UJ, UK.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Ho
authors.affiliation: Frimley Park Hospital NHS Foundation Trust, Frimley, Surrey, GU16 7UJ, UK.
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Knight
authors.affiliation: Dept. of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XW, UK.
authors.forename: John R
authors.initials: JR
authors.lastname: Cockcroft
authors.affiliation: Dept. of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XW, UK; Dept. of Respiratory Medicine, School of Medicine, Cardiff University, Academic Centre, University Hospital Llandough, Penarth, Vale of Glamorgan, CF64 2XX, UK.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Shale
authors.affiliation: NIHR Nottingham Respiratory Biomedical Research Unit, School of Clinical Sciences, University of Nottingham, City Hospital, Nottingham, UK. NG5 1PB, UK.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Bolton
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001158:Arteries / Q000187:drug effects* / Q000473:pathology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013147:Spirometry
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein