title: A new strategy for diurnal intraocular pressure curve.
abstract: OBJECTIVE
  To investigate whether there is agreement between intraocular pressure (IOP) readings in the supine position at 6 am upon awaking (before getting out of bed) and the IOP at 8 am, also measured in supine position after remaining 30 minutes in this position.
  
  
  METHODS
  In a sample of 50 eyes of 50 patients (normal, glaucoma suspect, and glaucoma patients), 6 am IOP was measured in the supine position upon awaking and before getting up, while 8 am IOP was measured on the same day, also in the supine position after 30 minutes in this position.
  
  
  RESULTS
  The IOP values at 6 am were mean 16.06±3 mmHg; median 15.5 mmHg (range 10-25.5 mmHg). For the 8 am readings, the average was 15.94±4 mmHg and the median 15 mmHg (range 10-25.5 mmHg). The difference between mean 6 and 8 am IOPs was 0.13±0.9 mmHg (confidence interval -0.14 to 0.40). Pearson correlation coefficient between the 6 and 8 am IOPs for the total sample was r=0.97 (p<0.05). There were no significant differences in behavior regarding eyes with high IOP as compared to normal IOP eyes (repeated-measure analysis of variance, p=0.72).
  
  
  CONCLUSIONS
  The 8 am IOP readings obtained in the supine position and under the conditions described were equivalent to 6 am IOP readings (as the first measure of the diurnal pressure curve [DPC]). This new strategy for DPC will make it a widely used tool in daily practice since it spares the need for hospitalization or home measurements.
authors.affiliation: Department of Ophthalmology, University of Buenos Aires, School of Medicine, Hospital de Clínicas José de San Martín, Buenos Aires - Argentina.
authors.forename: Roberto
authors.initials: R
authors.lastname: Borrone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D016683:Supine Position / Q000502:physiology*; D014065:Tonometry, Ocular; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents