title: Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice.
abstract: BACKGROUND
  Hilar cholangiocarcinoma is a malignant tumor that is difficult to cure. The aim of this study was to observe the effects of flow-controlled partial portal vein arterializations (PPVA) on liver regeneration after hepatectomy in minipigs with chronic obstructive jaundice.
  
  
  METHODS
  Eight minipigs were made into chronic obstructive jaundice models. United semi-hepatectomy, which imitates extended radical surgery for treatment of hilar cholangiocarcinoma, was then performed. The eight minipigs were randomly divided into groups A and B (n = 4 minipigs each). PPVA was performed in Group A but not in Group B. The effects of flow-controlled PPVA on live regeneration after hepatectomy were observed for 30 days after hepatectomy.
  
  
  RESULTS
  The portal vein PO(2) at the immediate time point and on postoperative day 30 was higher in Group A ((47.33 ± 2.43) and (48.50 ± 4.44) mmHg) than in Group B ((35.38 ± 4.06) and (35.55 ± 2.55) mmHg respectively, all P < 0.01). The mitotic index of liver cells on postoperative days 14 and 21 was higher in Group A (12.55% ± 2.85% and 15.25% ± 1.99% respectively) than in Group B (6.85% ± 2.10% and 11.88% ± 1.15% respectively, all P < 0.05). The regeneration rate of residual liver on postoperative days 14 and 21 was higher in Group A (24.56% ± 6.15% and 70.63% ± 9.83% respectively) than in Group B (11.96% ± 5.43% and 44.92% ± 7.42% respectively, P < 0.05 and P < 0.01 respectively).
  
  
  CONCLUSIONS
  Flow-controlled PPVA can promote liver regeneration after hepatectomy and prevent liver failure in minipigs with chronic obstructive jaundice.
authors.affiliation: Institute of Hepatobiliary Surgery, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Chen
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Chen
authors.forename: Yun-Yan
authors.initials: YY
authors.lastname: Wan
authors.forename: Wen-Gang
authors.initials: WG
authors.lastname: Li
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Huang
authors.forename: Xiao-Tong
authors.initials: XT
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000075:Acepromazine / Q000627:therapeutic use; D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D001285:Atropine / Q000627:therapeutic use; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D041781:Jaundice, Obstructive / Q000601:surgery*; D007649:Ketamine / Q000627:therapeutic use; D008115:Liver Regeneration / Q000502:physiology*; D011169:Portal Vein / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D000075:Acepromazine; D007649:Ketamine; D001285:Atropine