title: The safety of ustekinumab in psoriasis.
abstract: Ustekinumab is effective in the treatment of a variety of autoimmune conditions including psoriasis. As a relatively new therapeutic agent, its long-term effects are still under investigation. Short-term studies, however, have revealed ustekinumab to be generally well tolerated and safe. This article provides a comprehensive review of the pharmacokinetics of ustekinumab, its safety profile, adverse effects, and use in pregnancy. The effect of diabetes and prior immunosuppressant therapy is also addressed.
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Famenini
authors.forename: Jashin J
authors.initials: JJ
authors.lastname: Wu
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000493:pharmacokinetics*; D061067:Antibodies, Monoclonal, Humanized; D001835:Body Weight; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000493:pharmacokinetics*; D011247:Pregnancy; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism; D000069549:Ustekinumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007155:Immunologic Factors; D000069549:Ustekinumab