title: A human telomeric DNA-based chiral biosensor.
abstract: Here we report an electrochemical DNA (E-DNA) chiral sensor that can distinguish zinc-finger like metallo-supramolecular enantiomers based on human telomeric G-quadruplex formation specifically induced by one of the enantiomers. The assay is easy to operate and reusable with an enantioselective recognition ratio higher than 5.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Feng
authors.forename: Bailu
authors.initials: B
authors.lastname: Xu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D016615:Telomere / Q000235:genetics*
chemical_list: D008024:Ligands; D004247:DNA