title: Multifunctional magnetic calcium phosphate nanoparticles for targeted platin delivery.
abstract: Magnetic mesoporous amorphous calcium phosphate nanoparticles with a size of 62 nm and abundant -COOH groups on the surface have been prepared by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. By virtue of the carboxylate groups on the surface, the platinum pharmacophore cis-diaquadiamine platinum(II), folic acid and rhodamine isothiocyanate were conjugated on these magnetic calcium phosphate nanoparticles. The cytotoxicity and internalization efficiency of these nanocarriers have been evaluated on folate receptor overexpressed HeLa cells. These drug loaded nanoagents exhibit elevated cytotoxicity and induce apoptosis in HeLa cells.
authors.affiliation: Department of Chemistry, National Institute of Technology, Rourkela-769008, India.
authors.forename: Smruti R
authors.initials: SR
authors.lastname: Rout
authors.forename: Birendra
authors.initials: B
authors.lastname: Behera
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Maiti
authors.forename: Sasmita
authors.initials: S
authors.lastname: Mohapatra
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D002945:Cisplatin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007536:Isomerism; D008280:Magnetics; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry
chemical_list: D002130:Calcium Phosphates; D004337:Drug Carriers; D012235:Rhodamines; C020243:calcium phosphate; C027755:rhodamine isothiocyanate; D002945:Cisplatin