title: G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma.
abstract: Formylpeptide receptor1 (FPR1) is a G protein-coupled receptor (GPCR) originally identified in phagocytic leucocytes and mediates cell chemotaxis and activation in response to bacterial formylated chemotactic peptides. However, FPR1 also participates in a signal relay which regulates the infiltration of phagocytes, in particular neutrophils, to inflammatory sites in response to tissue-derived chemoattractant ligands. In addition to participating in innate immune responses, recently, FPR1 has been shown to be expressed by highly malignant glioblastoma (GBM) cells. Upon activation by an endogenous agonist Annexin 1 (Anx A1) released by necrotic glioma cells, FPR1 transactivates the receptor for epithelial growth factor (EGFR) and consequently to promote glioma cell chemotaxis, invasion, growth and production of angiogenic factors. The observations demonstrate that FPR1, as a multifunctional GPCR with pattern recognition properties, is not only involved in innate immune responses but also in the progression of GBM. Thus, FPR1 is an immunopharmacologic target for development of novel therapies.
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Keqiang
authors.initials: K
authors.lastname: Chen
authors.forename: Xiuwu
authors.initials: X
authors.lastname: Bian
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: Ji Ming
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000378:metabolism*
chemical_list: C469986:FPR1 protein, human; D044042:Receptors, Formyl Peptide