title: Delivery in female kidney transplant recipients with hepatitis C virus infection: is it safe for mother and newborn?
abstract: The aim of this report is to evaluate whether pregnancy is a risk factor for poor outcome of infection with hepatitis C virus or for allograft deterioration among kidney transplant recipients. The first case was in a 41-year-old pregnant kidney transplant recipient with hypercreatinemia and a history of toxic hepatitis. The second case was treated with interferon before transplant. Tacrolimus-based immunosuppressive regimens were used during the pregnancies. Hypertension complicated both pregnancies, and the pregnancies ended with cesarean delivery at preterm and term with healthy but low-weight newborns. The first patient became positive for hepatitis C virus RNA after pregnancy without a flare in transaminase level. Antibodies to hepatitis C virus were negative in the newborns. In conclusion, pregnancy should be promoted for kidney recipients infected with hepatitis C virus who have stable graft and liver function.
authors.affiliation: Mugla University School of Medicine, Mugla, Turkey. nevinyilmaz@mu.edu.tr
authors.forename: Nevin
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Ugur Eser
authors.initials: UE
authors.lastname: Yilmaz
authors.forename: Aysun
authors.initials: A
authors.lastname: Unal
authors.forename: Ethem
authors.initials: E
authors.lastname: Unal
authors.forename: Izzet
authors.initials: I
authors.lastname: Titiz
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D016030:Kidney Transplantation; D008111:Liver Function Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012042:Registries
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents