title: A randomised controlled trial of abdominal versus laparoscopic sacrocolpopexy for the treatment of post-hysterectomy vaginal vault prolapse: LAS study.
abstract: OBJECTIVE
  This prospective multi-centre true two-sided equivalence trial was designed to test the clinical equivalence of open (ASCP) and laparoscopic (LSCP) sacrocolpopexy using objective and subjective outcomes
  
  
  METHODS
  The study was carried out in three urogynaecology units in England, UK and the patient population consisted of women referred with symptomatic and bothersome post-hysterectomy vaginal vault prolapse at least 1 cm above or beyond the hymeneal remnants. The interventions were either abdominal or laparoscopic sacrocolpopexy following randomisation to one of the types of surgery.
  
  
  RESULTS
  For the primary outcome (point C on the POP-Q) the results at 1 year were -6.63 cm for the open ASCP and -6.67 cm for the LSCP respectively. Subjective outcomes at 1 year showed that 90% of the ASCP group and 80% of the LSCP group were "much better". There were improvements with regard to blood loss, haemoglobin and shorter length of stay in the LSCP group compared with the ASCP group.
  
  
  CONCLUSIONS
  This fully powered randomised controlled trial comparing open and laparoscopic sacrocolpopexy has shown clinical equivalence.
authors.affiliation: Urogynaecology Unit, Directorate of Women's Health, Derriford Hospital, Plymouth PL6 8DH, UK. robert.freeman@nhs.net
authors.forename: R M
authors.initials: RM
authors.lastname: Freeman
authors.forename: K
authors.initials: K
authors.lastname: Pantazis
authors.forename: A
authors.initials: A
authors.lastname: Thomson
authors.forename: J
authors.initials: J
authors.lastname: Frappell
authors.forename: L
authors.initials: L
authors.lastname: Bombieri
authors.forename: P
authors.initials: P
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Slack
authors.forename: P
authors.initials: P
authors.lastname: Scott
authors.forename: M
authors.initials: M
authors.lastname: Waterfield
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000368:Aged; D016063:Blood Loss, Surgical; D003127:Colposcopy / Q000379:methods*; D004739:England; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007902:Length of Stay; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome