title: Nuanced junctional RhoA activity.
abstract: RhoA signalling controls many diverse cellular processes, and thus discovering the mechanisms that determine its specific outcomes is a tantalizing challenge. A previously uncharacterized regulatory module operates selectively at the zonula adherens of epithelial cell junctions, in which positive and negative RhoA regulators are coordinated to fine-tune RhoA activity.
authors.forename: Swapnil S
authors.initials: SS
authors.lastname: Kher
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Worthylake
mesh_terms: D022005:Adherens Junctions / Q000502:physiology*; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004848:Epithelium / Q000502:physiology*; D005260:Female; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D015398:Signal Transduction; D051178:alpha Catenin / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D020690:GTPase-Activating Proteins; D008869:Microtubule-Associated Proteins; D010750:Phosphoproteins; D051178:alpha Catenin; C085379:rho GTPase-activating protein; C104434:spindlin