title: Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria.
abstract: OBJECTIVE
  We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria.
  
  
  METHODS
  The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined.
  
  
  RESULTS
  Among the baseline factors, eGFR and BNP had significant associations with the annual rate of decline in eGFR in Pearson correlation analysis (r=0.295, p=0.003; r=0.223, p=0.028, respectively). Multiple linear regression analysis also showed the significance of baseline eGFR and BNP as independent predictors of renal function (β=0.340, p=0.001; β=0.278, p=0.005, respectively). In multivariate logistic regression analysis, eGFR and BNP were independently associated with the risk of a decline in GFR (p=0.003, p=0.011, respectively). ROC curve analysis showed a cutoff value of BNP is 17.0 pg/mL for predicting a decline in GFR.
  
  
  CONCLUSIONS
  The BNP level at baseline is an independent predictor of the annual rate of decline in eGFR. Therefore, monitoring of BNP can play an important role in management of diabetic nephropathy.
authors.affiliation: Clinical Research Center, National Hospital Organization, Chiba-East National Hospital, 673 Nitona, Chuo-ku, Chiba City, Chiba, 260-8712, Japan. sekinao@cehpnet.com
authors.forename: Naoto
authors.initials: N
authors.lastname: Seki
authors.forename: Motonobu
authors.initials: M
authors.lastname: Nishimura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Motoharu
authors.initials: M
authors.lastname: Fukazawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Kenmochi
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain