title: Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa.
abstract: Two new dimeric sterols, manadosterols A (1) and B (2), were isolated from the marine sponge Lissodendryx fibrosa collected in Indonesia. The two compounds are comprised of two sulfonated sterol cores connected through the respective side chains. Manadosterols A (1) and B (2) inhibited the Ubc13-Uev1A interaction with IC(50) values of 0.09 and 0.13 μM, respectively. They are the second and third natural compounds showing inhibitory activities against the Ubc13-Uev1A interaction and are more potent than leucettamol A (IC(50), 106 μM), the first such inhibitor, isolated from another marine sponge.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Ushiyama
authors.forename: Hideharu
authors.initials: H
authors.lastname: Umaoka
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kato
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Suwa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morioka
authors.forename: Henki
authors.initials: H
authors.lastname: Rotinsulu
authors.forename: Fitje
authors.initials: F
authors.lastname: Losung
authors.forename: Remy E P
authors.initials: RE
authors.lastname: Mangindaan
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Yokosawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013107:Sphingolipids / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D013107:Sphingolipids; D013261:Sterols; C540199:leucettamol A; C576087:manadosterol A; C576088:manadosterol B