title: A meta-analysis of interleukin-10 -592 promoter polymorphism associated with gastric cancer risk.
abstract: We aimed to explore the role of IL-10 -592 A/C SNP in the susceptibility to gastric cancer through a systematic review and meta-analysis. Each initially included article was scored for quality appraisal. 17 studies were eligible for the meta-analysis. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated. IL-10-592 AA genotype is associated with the reduced risk of developing gastric cancer among Asians and even apparently observed among Asians high quality subgroup, suggesting IL-10-592 AA genotype may seem to be more protective from overall gastric cancer in Asian populations. IL-10-592 AA genotype is also associated with the overall reduced gastric cancer susceptibility in persons with H. pylori infection compared with controls without H. pylori infection, suggesting IL-10-592 AA genotype may seem to be more protective from overall gastric cancer susceptibility in persons infected with H. pylori. IL-10-592 AA genotype is not associated with either pathologic subtypes (intestinal or diffuse) or anatomic subtypes (non-cardia or cardia) of gastric cancer susceptibility. Genotyping methods like direct sequencing should be highly advocated to be conducted in future well-designed high quality studies among different ethnicities or populations.
authors.affiliation: Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease and Key Laboratory of Gastroenterology & Hepatology, Ministry of Health Shanghai Jiao-Tong University, Shanghai, People's Republic of China.
authors.forename: Huiping
authors.initials: H
authors.lastname: Xue
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Lin
authors.forename: Jianfu
authors.initials: J
authors.lastname: An
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Jinxian
authors.initials: J
authors.lastname: Chen
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Fang
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017594:Publication Bias; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10