title: DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands.
abstract: Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.
authors.affiliation: Institut de Science et Ingénierie Supramoléculaires, Université de Strasbourg, CNRS, Strasbourg, France. winssinger@unistra.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
mesh_terms: D002448:Cell Adhesion; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D015723:Gene Library; D006801:Humans; D008024:Ligands; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics
chemical_list: D008024:Ligands; D020135:Peptide Nucleic Acids; D011956:Receptors, Cell Surface; D004247:DNA