title: Chiral-Sc catalyzed asymmetric Michael addition/protonation of thiols with enones in water.
abstract: Asymmetric Michael reactions and enantioselective protonations between enones and thiols were catalyzed by a Sc(OTf)(3)-chiral 2,2'-bipyridine complex in water. The remarkable governing of the enantioselectivity for simple introduction of protons despite their abnormally high mobility in water may provide us with new synthetic opportunities as well as significant chemical advances.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Kitanosono
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Ueno
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi