title: Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.
abstract: The development of inflammation (experimental model of peritonitis induced by administration of sodium thioglycolate) was accompanied by a decrease in osmotic resistance of erythrocytes. Changes in osmotic resistance of erythrocytes associated with preliminary (15 min before induction of inflammation) administration of peptide Pro-Gly-Pro were significantly weaker, and the percentage of hemolyzed cells was reduced. The peptide injected against the background of developed inflammation (1 h 45 min after induction) had no corrective effect on osmotic resistance. During in vitro experiments, Pro-Gly-Pro did not affect hemolysis of intact erythrocytes. These results support the assumption that prophylactic administration of the peptide protects erythrocyte membranes and increases their osmotic resistance.
authors.affiliation: Department of Human and Animal Physiology, MV Lomonosov Moscow State University, Russia. mgolubeva46@mail.ru
authors.forename: M G
authors.initials: MG
authors.lastname: Golubeva
authors.forename: B A
authors.initials: BA
authors.lastname: Umarova
authors.forename: G N
authors.initials: GN
authors.lastname: Kopylova
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: N S
authors.initials: NS
authors.lastname: Bondarenko
authors.forename: O V
authors.initials: OV
authors.lastname: Cheremnova
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000187:drug effects*; D007249:Inflammation / Q000188:drug therapy*; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D009997:Osmotic Pressure / Q000187:drug effects*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
chemical_list: D009842:Oligopeptides; C113164:prolyl-glycyl-proline; D011392:Proline