title: c-Rel: shaping CD4 regulatory T cell development in unexpected ways.
abstract: In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings about how the c-Rel transcription factor orchestrates this developmental process.
authors.affiliation: The Australian Centre for Blood Diseases and Department of Clinical Hematology; Monash University Central Clinical School, Melbourne, VIC, Australia. steven.gerondakis@monash.edu
authors.forename: Steve
authors.initials: S
authors.lastname: Gerondakis
authors.forename: Tom
authors.initials: T
authors.lastname: Fulford
authors.forename: Raelene J
authors.initials: RJ
authors.lastname: Grumont
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D051858:Forkhead Transcription Factors / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D020569:Proto-Oncogene Proteins c-rel / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D020569:Proto-Oncogene Proteins c-rel