title: Development of Graves' disease after long-standing hypothyroidism on treatment, with acute toxicity to thionamides and lithium.
abstract: Thyroid hyperfunction in a patient with long-standing hypothyroidism is uncommon. Here, we describe and discuss the unusual scenario of development of severe skin rash to carbimazole, with subsequent acute toxicity to lithium in clinically indicated doses, in a patient who manifested hyperthyroidism after being on treatment for hypothyroidism for 7 years.
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Yashdeep
authors.initials: Y
authors.lastname: Gupta
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.forename: Ariachery C
authors.initials: AC
authors.lastname: Ammini
mesh_terms: D000368:Aged; D002231:Carbimazole / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000188:drug therapy*; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D013575:Syncope / Q000139:chemically induced; D013961:Thyroid Gland / Q000187:drug effects; D015431:Weight Loss
chemical_list: D007457:Iodine Radioisotopes; D002231:Carbimazole; D008094:Lithium