title: How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows.
abstract: It has been demonstrated for the first time that the heme protein cytochrome c (Cyt c) can enter the interior of a MOF despite the larger molecular dimension of the protein relative to the access pore sizes. Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Lykourinou
authors.forename: Carissa
authors.initials: C
authors.lastname: Vetromile
authors.forename: Tran
authors.initials: T
authors.lastname: Hoang
authors.forename: Li-June
authors.initials: LJ
authors.lastname: Ming
authors.forename: Randy W
authors.initials: RW
authors.lastname: Larsen
authors.forename: Shengqian
authors.initials: S
authors.lastname: Ma
mesh_terms: D045304:Cytochromes c / Q000378:metabolism*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D016062:Porosity; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D009942:Organometallic Compounds; D011506:Proteins; D045304:Cytochromes c