title: [Uricemia and metabolic syndrome in patients with arterial hypertension].
abstract: OBJECTIVE
  Serum urate levels have been associated with metabolic syndrome (MS). However, the relationship between these two variables in patients with essential arterial hypertension has not been studied.
  
  
  METHODS
  A Cross-sectional study in 592 patients with essential hypertension. The MS was defined according to the ATP-III criteria. We excluded patients with hypouricemic treatment.
  
  
  RESULTS
  The prevalence of MS was 52% (95% CI, 48-56%) and there was a graded increase with increasing serum urate (uricemia ≤ 4.7 mg/dl, 36%; uricemia ≥ 6.8 mg/dl, 70%, P < 0.001). Hypertensive patients with MS showed a higher mean uricemia than those without this comorbidity (6.1 ± 1.5 mg/dl versus 5.4 ± 1.3 mg/dl, P < 0.0001). The prevalence of hyperuricemia (men, > 7.0 mg/dL; women, > 6.0 mg/dL) in hypertensive patients without diuretic treatment, was 24% (in those with MS 40% versus 11% without MS). In multivariate analysis, triglycerides (OR = 1.008, CI 95%: 1.004-1.012, P < 0.001) and body mass index (BMI) (OR = 1.118, CI 95%: 1.059-1.181, P < 0.001), were independent predictors of serum uric acid levels.
  
  
  CONCLUSIONS
  In patients with essential hypertension, about half have MS and one out of four has hyperuricemia. The most important determinant of hyperuricemia is BMI.
authors.affiliation: Unidad de Hipertensión Arterial, Servicio de Medicina Interna, Hospital Universitario de Móstoles, Móstoles, Madrid, España. mlopezjimenez91@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: López-Jiménez
authors.forename: L
authors.initials: L
authors.lastname: Vigil-Medina
authors.forename: E
authors.initials: E
authors.lastname: Condés-Moreno
authors.forename: R
authors.initials: R
authors.lastname: García-Carretero
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Mejías
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Galiana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D033461:Hyperuricemia / Q000453:epidemiology / Q000209:etiology*; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012307:Risk Factors