title: A high body mass index is not a worse prognostic factor for endometrial carcinoma in a predominantly obese population.
abstract: OBJECTIVE
  We investigate if body mass index (BMI, kg × m(2)) is related to clinical-pathological characteristics in primary tumor and disease outcome in endometrial cancer.
  
  
  BACKGROUND
  Endometrial cancer incidence is increasing in industrialized countries. High BMI is associated with worse prognosis for many diseases.
  
  
  BACKGROUND
  Endometrial carcinoma is the most common gynecological malignancy in industrialized countries and the incidence has been increasing over the last few decades associated with obesity, however, it is not clear if a high BMI is associated with poor prognosis.
  
  
  METHODS
  In total, 147 women primarily treated for endometrial carcinoma at the Instituto Nacional de Cancerología during 2000-2005 were studied. Body mass index was available for all patients and related to comprehensive clinical and histopathological data.
  
  
  RESULTS
  High BMI was related to endometrioid histology and low/intermediate grade, and overweight/obese women had the same survival as the normal/underweight women. In survival analysis adjusting for age, histological subtype and grade, BMI showed no independent prognostic impact.
  
  
  CONCLUSIONS
  High BMI was significantly associated with markers of non-aggressive disease and women with high BMI had the same survival time in univariate analysis.
authors.affiliation: Anatomic Pathology, Instituto Nacional de Cancerología de México, Av. San Fernando 22 Col. Sección XVI, Mexico City, Mexico. saul.lino.sil@gmail.com
authors.forename: Leonardo Saúl
authors.initials: LS
authors.lastname: Lino-Silva
authors.forename: David Cantú
authors.initials: DC
authors.lastname: de León
authors.forename: Rosa Angélica
authors.initials: RA
authors.lastname: Salcedo-Hernández
authors.forename: Claudia
authors.initials: C
authors.lastname: Cavazos-Saman
authors.forename: María Delia
authors.initials: MD
authors.lastname: Pérez-Montiel
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D062606:Tertiary Care Centers