title: [Smooth muscle tumor of uncertain malignant potential (STUMP)--clinico-pathomorphological analysis of the cases and literature review].
abstract: OBJECTIVE
  This retrospective study was designed to evaluate the clinical and pathological features and outcomes of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP).
  
  
  METHODS
  Ten patients diagnosed with uterine STUMP and seen between 2008 and 2011 at the Memorial Cancer Center--Institute of Oncology in Warsaw were identified using the institution databases. Variables of interest included histopathological details, age at diagnosis, types of treatment and recurrence rate.
  
  
  RESULTS
  The mean age at diagnosis was 41 years (range 25-56 years). The mean follow-up time was 16 months (range 4-29 months). Diameter of the tumors ranged from 3 to 29 cm. Uterine bleeding was the second most frequent symptom observed in this cohort In three cases conservative procedure was performed, whereas in other patients hysterectomy was performed. No recurrence was observed during the follow-up period. In all tumors mitoses were less than 10 per 10/hpf, atypia of middle or severe type, and in 3 cases necrosis was observed. In half of the tumors expression of TP53 was found, and value of MIB 1 was estimated at 2-35%.
  
  
  CONCLUSIONS
  STUMP should be diagnosed by experienced pathologists due to the fact that they are often misdiagnosed as leiomyosarcomas. Clinical behavior of these tumors allows to consider a conservative management in patients wishing to preserve fertility
authors.affiliation: II Klinika Połoznictwa i Ginekologii WUM, Warszawa, Polska. bidzinski.m@gmail.com
authors.forename: Anna
authors.initials: A
authors.lastname: Dańska-Bidzińska
authors.forename: Elwira
authors.initials: E
authors.lastname: Bakuła-Zalewska
authors.forename: Anna
authors.initials: A
authors.lastname: Nasierowska-Guttmejer
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kowalewska
authors.forename: Edyta
authors.initials: E
authors.lastname: Barnaś
authors.forename: Piotr
authors.initials: P
authors.lastname: Sobiczewski
authors.forename: Mariusz
authors.initials: M
authors.lastname: Bidziński
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011044:Poland; D011379:Prognosis; D012189:Retrospective Studies; D018235:Smooth Muscle Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014594:Uterine Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53