title: Application of breast ultrasound in a mammography-based Chinese breast screening study.
abstract: We evaluated the clinical significance of the combined use of mammography + ultrasound as a new breast screening strategy. The inclusion criteria were: (1) females aged >40yrs; (2) breast cancer diagnosis by the breast image screening personnel at FUSCC; (3) screening by both ultrasound and mammography; (4) mammographic/sonographic images analyzed independently by different radiologists; and (5) follow-up for at least 1 year. Fifty-four women were enrolled. The analysis included diagnostic sensitivity of mammography, ultrasound, and mammography + ultrasound. The sensitivities of mammography and mammography + ultrasound were compared overall as well as among different age groups/breast densities. The screening sensitivity of mammography, ultrasound, and mammography + ultrasound was 79.6, 57.4, and 92.6 %, respectively. The difference between mammography and mammography + ultrasound was significant (P < 0.05). The benefit of including ultrasound with mammography as a new breast image screening strategy was found statistically significant in patients with dense breast on mammogram while it was non-significant in younger (<50 years) women. We, therefore, concluded that mammography + ultrasound increased the diagnostic sensitivity of breast screening; hence it was more desirable for women with dense breast on mammography.
authors.affiliation: Department of Oncology/Breast Surgery, Cancer Hospital & Breast Cancer Institute, Shanghai Medical College Institutes of Biomedical Sciences, Fudan University, 399 Ling-Ling Road, Shanghai 200032, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Ya-jie
authors.forename: Peng
authors.initials: P
authors.lastname: Wei-jun
authors.forename: Chang
authors.initials: C
authors.lastname: Cai
authors.forename: Ding
authors.initials: D
authors.lastname: Jian-hui
authors.forename: Zeng
authors.initials: Z
authors.lastname: Wei
authors.forename: Chen
authors.initials: C
authors.lastname: Min
authors.forename: Liu
authors.initials: L
authors.lastname: Guang-yu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001940:Breast; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008327:Mammography; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary