title: Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen: Case report and review of the literature.
abstract: BACKGROUND
  Sclerosing Angiomatoid Nodular Transformation of the spleen (SANT) is a rare benign vascular lesion of the spleen with extensive sclerosis and unknown etiology.
  
  
  METHODS
  We report a new case of SANT of the spleen found in a 53-year-old female following detection of a splenic mass on a routine computed tomography (CT). The patient underwent an uncomplicated laparoscopic splenectomy and the specimen was sent for histopathologic examination.
  
  
  CONCLUSIONS
  A review of the 97 reported cases of SANT found in the literature was undertaken. There were 43 males and 54 females with a median age of 46 years (range: 11-82 years). SANT is classically considered to be a female predominant disease, however 44.3% of reported case were male and the gender predilection may soon be neutralized as more cases are reported. 65 of the 97 (67%) patients were in 30-60 year age group. The majority of lesions (n=50) were incidentally found on imaging, and for those patients presenting with symptoms, abdominal pain (n=18) was the predominant symptom.
  
  
  CONCLUSIONS
  The diagnosis of SANT should be considered in any patient presenting with a splenic lesion that contains an angiomatoid or inflammatory component. As the differential diagnosis for SANT includes malignant pathologies, and currently no reliable diagnostic radiological feature has been identified to differentiate between these conditions, SANT will continue to be diagnosed on the basis of surgical histopathology.
authors.affiliation: Department of General Surgery, Cleveland Clinic Foundation, Digestive Disease Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
authors.forename: Gavin A
authors.initials: GA
authors.lastname: Falk
authors.forename: Nishank P
authors.initials: NP
authors.lastname: Nooli
authors.forename: Gareth
authors.initials: G
authors.lastname: Morris-Stiff
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Plesec
authors.forename: Steven
authors.initials: S
authors.lastname: Rosenblatt