title: How the ubiquitin proteasome system regulates the regulators of transcription.
abstract: The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradation of activators aids or restricts their function.
authors.affiliation: Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Gary
authors.initials: G
authors.lastname: Ee
authors.forename: Norbert
authors.initials: N
authors.lastname: Lehming
mesh_terms: D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D014157:Transcription Factors; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex