title: Unraveling the KNOTTED1 regulatory network in maize meristems.
abstract: KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors function in plant meristems, self-renewing structures consisting of stem cells and their immediate daughters. We defined the KN1 cistrome in maize inflorescences and found that KN1 binds to several thousand loci, including 643 genes that are modulated in one or multiple tissues. These KN1 direct targets are strongly enriched for transcription factors (including other homeobox genes) and genes participating in hormonal pathways, most significantly auxin, demonstrating that KN1 plays a key role in orchestrating the upper levels of a hierarchical gene regulatory network that impacts plant meristem identity and function.
authors.affiliation: Plant Gene Expression Center, U.S. Department of Agriculture-Agricultural Research Service, Plant and Microbial Biology Department, University of California at Berkeley, 94720, USA.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bolduc
authors.forename: Alper
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Maria Katherine
authors.initials: MK
authors.lastname: Mejia-Guerra
authors.forename: Kengo
authors.initials: K
authors.lastname: Morohashi
authors.forename: Devin
authors.initials: D
authors.lastname: O'Connor
authors.forename: Erich
authors.initials: E
authors.lastname: Grotewold
authors.forename: Sarah
authors.initials: S
authors.lastname: Hake
mesh_terms: D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D005796:Genes / Q000235:genetics*; D056426:Genetic Loci; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000378:metabolism; D018519:Meristem / Q000235:genetics* / Q000378:metabolism; D010937:Plant Growth Regulators / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D003313:Zea mays / Q000235:genetics* / Q000378:metabolism
chemical_list: D018398:Homeodomain Proteins; D007210:Indoleacetic Acids; C095848:Kn1 protein, plant; D010937:Plant Growth Regulators; D010940:Plant Proteins