title: Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor.
abstract: Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pH(e) ), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment.
authors.affiliation: Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China.
authors.forename: You-Yong
authors.initials: YY
authors.lastname: Yuan
authors.forename: Cheng-Qiong
authors.initials: CQ
authors.lastname: Mao
authors.forename: Xiao-Jiao
authors.initials: XJ
authors.lastname: Du
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: Du
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D011091:Polyesters / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014183:Transplantation, Heterologous
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D004317:Doxorubicin