title: Ring expansion of spiro-thiolactam in rhodamine scaffold: switching the recognition preference by adding one atom.
abstract: A new rhodamine spiro scaffold with a six-membered reactive ring was developed by inserting a nitrogen atom in the known probe rhodamine B spiro thiohydrazide, which switched the recognition preference of the probe from Hg(2+) to Cu(2+). This probe is shown to be an efficient "turn-on" fluorescent chemodosimeter for Cu(2+) in a neutral aqueous medium. Mechanism studies suggested that the probe opened its spiro-ring by a Cu(2+)-induced transformation of the cyclic thiosemicarbazide moiety to an isothiocyanate group.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, and the MOE Key Laboratory of Analytical Sciences, Xiamen University, Xiamen 361005, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wu
authors.forename: Qing-Na
authors.initials: QN
authors.lastname: Bian
authors.forename: Bian-Guo
authors.initials: BG
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Cai
authors.forename: Shu-Dong
authors.initials: SD
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Shi-Yao
authors.initials: SY
authors.lastname: Yang
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Jiang
mesh_terms: D003300:Copper / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D008628:Mercury / Q000032:analysis*; D015394:Molecular Structure; D012235:Rhodamines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*; D014867:Water
chemical_list: D005456:Fluorescent Dyes; D006834:Hydrazines; D012235:Rhodamines; D013141:Spiro Compounds; C514777:rhodamine B thiohydrazide; D014867:Water; D003300:Copper; D008628:Mercury