title: Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP.
abstract: TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.
authors.affiliation: Institut de Biologie Structurale Jean-Pierre Ebel, CEA, 41, rue Jules Horowitz, 38027 Grenoble, France.
authors.forename: Matthieu P M H
authors.initials: MP
authors.lastname: Benoit
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Plevin
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011485:Protein Binding; D017433:Protein Structure, Secondary; D012322:RNA Precursors / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D000099253:Trans-Activation Responsive RNA-Binding Protein
chemical_list: D035683:MicroRNAs; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D000099253:Trans-Activation Responsive RNA-Binding Protein