title: Prevalence of high-level mupirocin resistance among meticillin-resistant Staphylococcus aureus isolates in a tertiary care hospital in Singapore.
abstract: High-level resistance to mupirocin in meticillin-resistant Staphylococcus aureus (MRSA) jeopardizes its role in nasal decolonization protocols. We carried out a study in 2010 to determine the prevalence of high-level mupirocin resistance in our tertiary-care hospital. The prevalence of high-level resistance to mupirocin in MRSA in this hospital was 11%. There was also complete agreement between the genotypic and phenotypic methods of detection of high-level mupirocin resistance in 24 of the screening isolates.
authors.affiliation: Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore. drsaugata@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Choudhury
authors.forename: P U
authors.initials: PU
authors.lastname: Krishnan
authors.forename: B
authors.initials: B
authors.lastname: Ang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000379:methods; D016712:Mupirocin / Q000494:pharmacology*; D010641:Phenotype; D015995:Prevalence; D012846:Singapore / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D062606:Tertiary Care Centers
chemical_list: D000900:Anti-Bacterial Agents; D016712:Mupirocin