title: Good penetration of moxifloxacin into human abscesses.
abstract: Abscesses are often treated with antibiotics in addition to incision or when incision is unfeasible, but accurate information about antibiotic abscess penetration in humans is missing. This study aimed at evaluating the penetration of moxifloxacin into human abscesses. After administration of a single dose of 400 mg moxifloxacin, drug concentrations were measured in 10 differently located abscesses at incision, and in plasma over 8 h. At incision performed 0.9-4.8 h after administration, moxifloxacin concentrations in abscesses ranged from ≤0.01 to 9.2 mg/l (1.9 ± 3.4 mg/l), indicating pronounced drug accumulation in some abscesses. The degree of abscess penetration could not be explained by covariates like the ratio of surface area to volume or pH of abscesses, or by moxifloxacin plasma concentrations. Concluding, moxifloxacin was detectable in most abscesses and may be a useful antibiotic for this indication. However, antibiotic abscess penetration was highly variable and unpredictable, suggesting surgical abscess incision whenever possible.
authors.affiliation: Departments of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. robert.sauermann@meduniwien.ac.at
authors.forename: Robert
authors.initials: R
authors.lastname: Sauermann
authors.forename: Rudolf
authors.initials: R
authors.lastname: Karch
authors.forename: Maria C
authors.initials: MC
authors.lastname: Kjellsson
authors.forename: Thomas
authors.initials: T
authors.lastname: Feurstein
authors.forename: Andreas
authors.initials: A
authors.lastname: Püspök
authors.forename: Herbert
authors.initials: H
authors.lastname: Langenberger
authors.forename: Michaela
authors.initials: M
authors.lastname: Böhmdorfer
authors.forename: Walter
authors.initials: W
authors.lastname: Jäger
authors.forename: Markus
authors.initials: M
authors.lastname: Zeitlinger
mesh_terms: D000038:Abscess / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001372:Aza Compounds / Q000493:pharmacokinetics* / Q000494:pharmacology; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000077266:Moxifloxacin; D011804:Quinolines / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin