title: Feasibility of oncoplastic techniques in the surgical management of locally advanced breast cancer.
abstract: BACKGROUND
  Locally advanced breast cancer (LABC) is still common in developing countries. The association between neoadjuvant chemotherapy (NC) and oncoplastic surgery (OS) might provide an oncological treatment with satisfactory aesthetic results.
  
  
  OBJECTIVE
  The goal was to demonstrate if oncoplastic surgical techniques can be utilized to treat LABC which was submitted to neoadjuvant chemotherapy.
  
  
  METHODS
  This prospective clinical trial included breast cancer patients, clinical stage III, who underwent established NC regimen. All patients underwent preoperative planning to control the tumor size and to define the surgical technique. A detailed analysis of the pathological specimen was performed.
  
  
  RESULTS
  50 patients were assessed and surgically treated. Tumor size ranged from 3.0 to 14.0 cm (median 6.5 cm). Pathologic response was rated as stable, progressive, partial response, and complete response in 10%, 8%, 80% and 2% of the cases, respectively. Seventeen (34%) patients were submitted to OS. No patient had positive margins. Skin involvement was presented in 36% of pathologic specimen.
  
  
  CONCLUSIONS
  Oncoplastic surgical techniques for selected patients decrease the rates of radical surgery despite large tumors. (www.clinicaltrials.gov, NCT00820690).
authors.affiliation: Department of Gynaecology, Obstetrics and Mastology, School of Medicine of Botucatu, UNESP-Distrito de Rubião Júnior, Botucatu-SP, Brazil. anguz75@gmail.com
authors.forename: Angelo Gustavo
authors.initials: AG
authors.lastname: Zucca Matthes
authors.forename: Gilberto
authors.initials: G
authors.lastname: Uemura
authors.forename: Ligia
authors.initials: L
authors.lastname: Kerr
authors.forename: Ângelo Carmo Silva
authors.initials: ÂC
authors.lastname: Matthes
authors.forename: Rodrigo Augusto D
authors.initials: RA
authors.lastname: Michelli
authors.forename: Maria Aparecida Azevedo Koike
authors.initials: MA
authors.lastname: Folgueira
authors.forename: Rene Aloísio
authors.initials: RA
authors.lastname: da Costa Viera
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D017239:Paclitaxel