title: [Effect of different water-soluble forms of the fullerene C60 on the metabolic activity and ultra-structure of cells in culture].
abstract: In view of contradictory data on the toxicity of fullerenes for live organisms we studied the effect of water-soluble complexes of C60 with N-polyvivyl-pirrolidone (C60/PVP) and gamma-cyclodextrine (C60/gamma-CD) on MA-104 cells in culture. Both complexes proved to be non-toxic for cultured cells in the dark in wide range of concentrations. Both complexes provoke changes of cellular ultra-structure which reflect the enhancement of metabolic activity. At the same time only the exposition with the complex C60/PVP leads to the essential growth of number and size of mitochondria. However, the effect of two studied water-soluble forms of C60 under intensive UV-irradiation of cells proved to be opposite: C60/PVP had a cyto-protective action while C60/gamma-CD caused a significant growth of photo-toxicity. Possible reasons of the differences in the action of different forms of C60 on living organisms are discussed.
authors.forename: E M
authors.initials: EM
authors.lastname: Eropkina
authors.forename: E V
authors.initials: EV
authors.lastname: Il'inskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Litasova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Eropkin
authors.forename: L B
authors.initials: LB
authors.lastname: Piotrovskiĭ
authors.forename: M A
authors.initials: MA
authors.lastname: Dumpis
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
mesh_terms: D000818:Animals; D002460:Cell Line; D037741:Fullerenes / Q000737:chemistry / Q000633:toxicity*; D008253:Macaca mulatta; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D011205:Povidone / Q000378:metabolism / Q000633:toxicity; D012995:Solubility; D014466:Ultraviolet Rays; D047408:gamma-Cyclodextrins / Q000378:metabolism / Q000633:toxicity
chemical_list: D037741:Fullerenes; D047408:gamma-Cyclodextrins; D011205:Povidone; C023792:gamma-cyclodextrin; C069837:fullerene C60