title: Potential implication of activating killer cell immunoglobulin-like receptor and HLA in onset of pulmonary tuberculosis.
abstract: Killer cell immunoglobulin-like receptor (KIR) and human leucocyte antigen (HLA) play crucial role in maintaining immune homoeostasis and controlling immune responses. To investigate the influence of KIR and HLA-C ligands on the risk of pulmonary tuberculosis (PTB), we studied 200 patients who were confirmed to have PTB and 200 healthy controls on the different frequencies of KIR and HLA-C ligands. Genotyping of these genes was conducted by sequence-specific primer polymerase chain reaction (SSP-PCR) method. Gene frequencies were compared between PTB group and the control group by χ(2) test, and P < 0.05 was regarded as statistically significant. As a result, the frequency of KIR genotype A/B was increased in PTB than controls but A/A was decreased. Moreover, striking differences were observed in the frequencies of HLA-Cw*08 between the two groups. Besides, the frequencies of '2DL2/3 with C1' in PTB were increased compared with control group. In addition, individuals with no KIR2DS3 and no Cw*08 were higher in controls than in PTB. KIR2DS1 was increased in PTB when HLA-C group 2 alleles were missing. In conclusion, KIR and HLA-C gene polymorphisms were related to susceptibility to PTB.
authors.affiliation: Department of Laboratory Medicine, Provincial Hospital affiliated to Shandong University, Jinan, China.
authors.forename: C
authors.initials: C
authors.lastname: Lu
authors.forename: X L
authors.initials: XL
authors.lastname: Bai
authors.forename: Y J
authors.initials: YJ
authors.lastname: Shen
authors.forename: Y F
authors.initials: YF
authors.lastname: Deng
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Fan
authors.forename: J X
authors.initials: JX
authors.lastname: Chu
authors.forename: S M
authors.initials: SM
authors.lastname: Zhao
authors.forename: B C
authors.initials: BC
authors.lastname: Zhang
authors.forename: Y R
authors.initials: YR
authors.lastname: Zhao
authors.forename: C Z
authors.initials: CZ
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Ye
authors.forename: Z M
authors.initials: ZM
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics* / Q000502:physiology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D054340:Receptors, KIR / Q000235:genetics* / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000209:etiology / Q000235:genetics* / Q000276:immunology
chemical_list: D015236:HLA-C Antigens; D054340:Receptors, KIR