title: Cutaneous wart-associated HPV types: prevalence and relation with patient characteristics.
abstract: BACKGROUND
  Epidemiological data on cutaneous wart-associated HPV types are rare.
  
  
  OBJECTIVE
  To examine the prevalence of cutaneous wart-associated HPV types and their relation with patient characteristics.
  
  
  METHODS
  Swabs were taken from all 744 warts of 246 consecutive immunocompetent participants and analysed by a broad spectrum HSL-PCR/MPG assay. Patient details including location, duration, and number of warts were recorded.
  
  
  RESULTS
  No HPV DNA was detected in 49 (7%) swabs, a single HPV type in 577 (78%) swabs, and multiple HPV types in 118 (16%) swabs. HPV 2, 27 and 57 (alpha genus), HPV 4 (gamma genus) and HPV 1 (mu genus) were the most frequently detected HPV types, and HPV 63 (mu genus) was only frequently detected together with other HPV types. Less frequently detected HPV types were HPV 3, 7, 10 and 28 (alpha genus), 65, 88 and 95 (gamma genus) and 41 (nu genus). Warts containing HPV 1 showed the most distinct clinical profile, being related to children aged <12 years, plantar location, duration <6 months, and to patients with <4 warts.
  
  
  CONCLUSIONS
  HPV 27, 57, 2 and 1 are the most prevalent HPV types in cutaneous warts in general population. Warts infected with HPV 1 have a distinct clinical profile.
authors.affiliation: Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. s.c.bruggink@lumc.nl
authors.forename: Sjoerd C
authors.initials: SC
authors.lastname: Bruggink
authors.forename: Maurits N C
authors.initials: MN
authors.lastname: de Koning
authors.forename: Jacobijn
authors.initials: J
authors.lastname: Gussekloo
authors.forename: Paulette F
authors.initials: PF
authors.lastname: Egberts
authors.forename: Jan
authors.initials: J
authors.lastname: Ter Schegget
authors.forename: Mariet C W
authors.initials: MC
authors.lastname: Feltkamp
authors.forename: Jan Nico Bouwes
authors.initials: JN
authors.lastname: Bavinck
authors.forename: Wim G V
authors.initials: WG
authors.lastname: Quint
authors.forename: Willem J J
authors.initials: WJ
authors.lastname: Assendelft
authors.forename: Just A H
authors.initials: JA
authors.lastname: Eekhof
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D017193:Skin Diseases, Viral / Q000453:epidemiology / Q000821:virology*; D014860:Warts / Q000453:epidemiology / Q000821:virology*; D055815:Young Adult