title: Association of STXBP4/COX11 rs6504950 (G>A) polymorphism with breast cancer risk: evidence from 17,960 cases and 22,713 controls.
abstract: OBJECTIVE
  Epidemiological studies have investigated the association between STXBP4/COX11 rs6504950 (G>A) polymorphism and breast cancer susceptibility. However, the results are still controversial. Hence, we conducted a meta-analysis of the STXBP4/COX11 polymorphism and risk of breast cancer to obtain the most reliable estimate of the association.
  
  
  METHODS
  PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between STXBP4/COX11 rs6504950 (G>A) polymorphism with breast cancer risk.
  
  
  RESULTS
  A total of four eligible studies including 17,960 cases and 22,713 controls based on the search criteria were involved in this meta-analysis. The distributions of genotypes in the controls were all in agreement with Hardy-Weinberg equilibrium. We observed that STXBP4/COX11 rs6504950 polymorphism was significantly correlated with breast cancer risk when all studies were pooled into the meta-analysis (the allele contrast model: OR = 0.93, 95% CI = 0.87-0.99; the heterozygote codominant model: OR = 0.87, 95% CI = 0.83-0.90; the dominant model OR = 0.92, 95% CI = 0.88-0.96).
  
  
  CONCLUSIONS
  This meta-analysis indicated that the rs6504950 AA/AG genotypes are associated with a significantly decreased risk of breast carcinogenesis.
authors.affiliation: Department of Oncology, Jinling Hospital, Medical School of Nanjing University, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Nie
authors.forename: Long-Bang
authors.initials: LB
authors.lastname: Chen
authors.forename: Xiao-Xiang
authors.initials: XX
authors.lastname: Guan
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D000079922:Copper Transport Proteins; D045222:Electron Transport Chain Complex Proteins; D003576:Electron Transport Complex IV / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D024101:Mitochondrial Proteins; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D033921:Vesicular Transport Proteins
chemical_list: C484188:COX11 protein, human; D000079922:Copper Transport Proteins; D045222:Electron Transport Chain Complex Proteins; D024101:Mitochondrial Proteins; C498469:STXBP4 protein, human; D033921:Vesicular Transport Proteins; D003576:Electron Transport Complex IV