title: Impact of postoperative hemodynamics in patients with functional single ventricle undergoing Fontan completion before weighing 10 kg.
abstract: BACKGROUND
  Although the Fontan procedure is now being performed in younger patients, the influence of the early timing of Fontan on midterm to long-term results remains unclear. We investigated whether the timing of Fontan completion affects subsequent hemodynamics in patients with functional single ventricle followed for more than 3 years.
  
  
  METHODS
  Between January 1997 and December 2008, 163 patients with functional single ventricle underwent extracardiac total cavopulmonary connection (TCPC) at a single institution. The survivors routinely underwent postoperative catheterization at 1 year and then every 5 years after TCPC and were divided into group A (weight < 10 kg; n = 65) and group B (weight > 10 kg; n = 97), and retrospectively reviewed.
  
  
  RESULTS
  Mean follow-up was 6.6 ± 3.7 years. Mean weight and conduit size were 8.5 ± 0.8 kg and 17.1 ± 1.2 mm for group A versus 20.2 ± 13.1 kg and 18.8 ± 1.9 mm for group B, respectively (p < 0.001). There were 3 hospital deaths (group A, n = 1; group B, n = 2) and 5 late deaths (group A, n = 3; group B, n = 2). No TCPC was taken down. There were no thromboembolic events in either group. The end-diastolic volume of ventricle (eDV) (% of normal) was (232.7 ± 91.4 before TCPC versus 139.3 ± 57.2 5 years after TCPC; p < 0.001) in group A and (209.6 ± 77.7 before TCPC versus 136.7 ± 61.4 5 years after TCPC; p < 0.001) in group B. Ventricular ejection fraction and cardiac index at 5 years were similar in both groups. The end-diastolic pressure of ventricle (eDP) (mm Hg) at 1 year (p = 0.0037) and at 5 years (p = 0.047) was significantly lower in group A compared with group B.
  
  
  CONCLUSIONS
  TCPC can be performed earlier with good intermediate results. Earlier unloading of a univentricular heart by means of TCPC might be advantageous for preservation of future ventricular function.
authors.affiliation: Department of Cardiovascular Surgery, Mt. Fuji Shizuoka Children's Hospital, Shizuoka, Japan.
authors.forename: Noritaka
authors.initials: N
authors.lastname: Ota
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Masaya
authors.initials: M
authors.lastname: Murata
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tosaka
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Ide
authors.forename: Maiko
authors.initials: M
authors.lastname: Tachi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ito
authors.forename: Ai
authors.initials: A
authors.lastname: Sugimoto
authors.forename: Kisaburo
authors.initials: K
authors.lastname: Sakamoto
mesh_terms: D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D018729:Fontan Procedure; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D016276:Ventricular Function