title: Long-term follow-up and pattern of failure for T1-T2 glottic cancer after definitive radiation therapy.
abstract: OBJECTIVE
  To evaluate the impact of radiation therapy (RT) on the long-term outcomes and pattern of failure for T1-2 glottic cancer.
  
  
  METHODS
  This is a single-institution, retrospective study. From January (1997 to 2010), 253 patients with early glottic cancer underwent RT by 2-dimensional or 3-dimensional RT with Co or linear accelerator. Appropriate daily bolus was applied with linear accelerator-based RT to avoid under dosage of the anterior commissure.
  
  
  RESULTS
  A total of 253 patients with T1-T2 glottic cancer were treated with definitive RT. The median age was 65 and males made up 87% of the population. T1 was 77% of the population. The median dose and fraction size were 63 and 2.25 Gy, respectively. After a median follow-up of 83 months, the locoregional control (LRC) for the whole cohort was 98%. Specifically, LRCs for T1 (195 patients) and T2 (58 patients) were 99.5% and 91%, respectively. Kaplan-Meier curve shows the 5-year cause-specific survival to be 100%.
  
  
  CONCLUSIONS
  Single-modality RT provides an excellent and effective treatment for T1-T2 glottic cancer with remarkable functional preservation and 5-year LRC of 98% with negligible long-term toxicity.
authors.affiliation: *Department of Radiation Oncology, Beth Israel Medical Center †Department of Radiation Oncology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY.
authors.forename: Waleed Fouad
authors.initials: WF
authors.lastname: Mourad
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Hu
authors.forename: Rania A
authors.initials: RA
authors.lastname: Shourbaji
authors.forename: Rudolph
authors.initials: R
authors.lastname: Woode
authors.forename: Louis B
authors.initials: LB
authors.lastname: Harrison
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D015331:Cohort Studies; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003037:Cobalt Radioisotopes