title: [The effect of agmatine on L-arginine metabolism in erythrocytes under streptozotocin-induced diabetes in rats].
abstract: The effects of agmatine on oxidative and nonoxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.
authors.forename: I V
authors.initials: IV
authors.lastname: Ferents
authors.forename: I V
authors.initials: IV
authors.lastname: Brodiak
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Liuta
authors.forename: V A
authors.initials: VA
authors.lastname: Burda
authors.forename: A M
authors.initials: AM
authors.lastname: Fedorovych
authors.forename: N O
authors.initials: NO
authors.lastname: Sybirna
mesh_terms: D000376:Agmatine / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001119:Arginase / Q000097:blood*; D001120:Arginine / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000097:blood*; D009573:Nitrites / Q000097:blood; D009952:Ornithine / Q000097:blood; D051381:Rats; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D013311:Streptozocin; D000376:Agmatine; D001120:Arginine; D009952:Ornithine; D019001:Nitric Oxide Synthase; D001119:Arginase