title: Assessment of effective absorbed dose of (111)In-DTPA-Buserelin in human on the basis of biodistribution rat data.
abstract: In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of (111)In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of (111)In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.
authors.affiliation: Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, 16 Azar Street, Tehran, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Lahooti
authors.forename: Saeed
authors.initials: S
authors.lastname: Shanehsazzadeh
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jalilian
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Tavakoli
mesh_terms: D000818:Animals; D002064:Buserelin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002614:Chelating Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007205:Indium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007269:Injections, Intra-Arterial; D008954:Models, Biological; D009928:Organ Specificity; D004369:Pentetic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D005300:Fertility Agents, Female; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D004369:Pentetic Acid; D002064:Buserelin