title: Argentum-quarz solution in the treatment of anorectal fistulas: is it possible a conservative approach?
abstract: Patients suffering from chronic intestinal diseases (Crohn's disease, Ulcerative Colitis, Indeterminate Colitis) are prone to the development of pyogenic complications. These complications are most commonly in the form of perianal or intraabdominal abscesses and/or fistulas. The treatment of these complications are managed differently but, after an initial treatment based on medical or minimally invasive management, the solution of the pathological condition is always achieved by a surgical procedure. In the last few years prospective studies have proposed an alternative conservative therapeutic approach based on application of fibrin glue in the healing of patients with fistulas-in-ano. In this paper we suggest and discuss the therapeutic potential of silver and quarz in the conservative treatment of anorectal fistulas pointing out their role in modulating particular steps of the pathogenetic process which characterizes this pathological condition.
authors.affiliation: Department of Surgical and Oncologica! Disciplines (DiChirOn), University of Palermo, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tomasello
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bellavia
authors.forename: Francesco
authors.initials: F
authors.lastname: Damiani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damiano
authors.forename: Vincenzo Davide
authors.initials: VD
authors.lastname: Palumbo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Fiorentini
authors.forename: Robero
authors.initials: R
authors.lastname: Puleio
authors.forename: Gabriele
authors.initials: G
authors.lastname: Spinelli
authors.forename: Provvidenza
authors.initials: P
authors.lastname: Damiani
authors.forename: Silvia
authors.initials: S
authors.lastname: Ficarella
authors.forename: Antonio
authors.initials: A
authors.lastname: Bruno
authors.forename: Attilio Ignazio
authors.initials: AI
authors.lastname: Lo Monte
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D011791:Quartz / Q000008:administration & dosage*; D012003:Rectal Fistula / Q000473:pathology / Q000628:therapy*; D012834:Silver / Q000008:administration & dosage*; D012996:Solutions; D014945:Wound Healing / Q000187:drug effects
chemical_list: D015718:Fibrin Tissue Adhesive; D012996:Solutions; D011791:Quartz; D012834:Silver