title: Pathological findings of infraorbital nerve enlargement in IgG4-related ophthalmic disease.
abstract: OBJECTIVE
  We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings.
  
  
  METHODS
  An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed IgG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well.
  
  
  CONCLUSIONS
  IONE in IgG4-related ophthalmic disease is due to IgG4-related disease involving the epineurium.
authors.affiliation: Department of Ophthalmology, Mitoyo General Hospital, 708 Himehama, Toyohama-cho, Kanonji, Kagawa 769-1695, Japan. rivon-sogabe@k9.dion.ne.jp
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sogabe
authors.forename: Katsuya
authors.initials: K
authors.lastname: Miyatani
authors.forename: Rieko
authors.initials: R
authors.lastname: Goto
authors.forename: Gengo
authors.initials: G
authors.lastname: Ishii
authors.forename: Koh-Ichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Sato
mesh_terms: D005094:Exophthalmos / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006984:Hypertrophy; D007074:Immunoglobulin G / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014276:Trigeminal Nerve / Q000473:pathology*
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone