title: Immunotherapy for fungal infections.
abstract: Invasive fungal infections have become a major cause of mortality in immunocompromised individuals. Despite the current availability of number of highly active antifungal agents, overall mortality remains around 40%. Importantly, it is clear that a failure to restore host immunity leads to worse outcomes. These observations provide clear rationale for the development of novel immunotherapies to improve outcomes in immunocompromised individuals with invasive fungal infections. In this article we summarise the key advances that have been made in the field of immunotherapy for fungal infections in recent years, with a particular focus on clinical studies of interferon-γ therapy, adoptive T cell therapy, and gene therapy for chronic granulomatous disorder. In addition a number of pre-clinical approaches are reviewed.
authors.affiliation: Section of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
authors.forename: Darius
authors.initials: D
authors.lastname: Armstrong-James
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Harrison
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D015316:Genetic Therapy; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000235:genetics / Q000628:therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D007371:Interferon-gamma / Q000627:therapeutic use; D009181:Mycoses / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000935:Antifungal Agents; D007371:Interferon-gamma