title: Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death.
abstract: In this review, we will discuss the current knowledge on IL-32 and provide new insights regarding the biological function of IL-32. IL-32 is seen as a cytokine that can induce a range of proinflammatory mediators and contribute to autoimmune diseases, such as rheumatoid arthritis, however present knowledge demonstrates that IL-32 is not a classical cytokine. We present the history of this cytokine, the role of IL-32 in several diseases and discuss a possible novel role of intracellular IL-32 in cell homeostasis. Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions.
authors.affiliation: Department of Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Heinhuis
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Wim B
authors.initials: WB
authors.lastname: van den Berg
authors.forename: Charles A
authors.initials: CA
authors.lastname: Dinarello
authors.forename: Leo A B
authors.initials: LA
authors.lastname: Joosten
mesh_terms: D000818:Animals; D016923:Cell Death; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology* / Q000473:pathology*; D018836:Inflammation Mediators / Q000737:chemistry / Q000378:metabolism*; D007378:Interleukins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism*
chemical_list: C496971:IL32 protein, human; D018836:Inflammation Mediators; D007378:Interleukins