title: Psoriasis and metabolic syndrome: is peroxisome proliferator-activated receptor-γ part of the missing link?
abstract: BACKGROUND
  Growing evidence points to a causative relationship between altered activity of peroxisome proliferator-activated receptor γ (PPARγ) and psoriasis on the one hand, and its relationship with metabolic syndrome (MS) on the other.
  
  
  OBJECTIVE
  Could altered PPARγ levels be one of the culprits responsible for translating the metabolic state among psoriatic patients?
  
  
  METHODS
  This investigational cross-sectional study included 60 psoriatics and 60 controls. Subjects were subgrouped according to the presence or absence of MS. Biopsies were taken from all subjects for immunohistochemical staining for PPARγ and western blot technique was carried out.
  
  
  RESULTS
  PPARγ immunostaining in psoriatics was significantly lower than in controls with the lowest levels documented in patients with MS (P<0.001). PPARγ immunostaining level was significantly lower in diabetics, hypertensive and insulin resistance patients (P<0.05). It also showed a significant positive correlation with high density lipoprotein (HDL) levels and significant negative correlation with age, psoriasis area and severity index (PASI), body mass index, and blood glucose levels. Similar results were obtained by western blot technique.
  
  
  CONCLUSIONS
  Reduced PPARγ could be added to the factors responsible for translating the metabolic state among psoriatic patients. PPARγ agonists can present an adjuvant therapeutic tool in treatment of psoriatics with MS.
authors.affiliation: Dermatology Department.
authors.forename: Rehab A
authors.initials: RA
authors.lastname: Hegazy
authors.forename: Rania M
authors.initials: RM
authors.lastname: Abdel Hay
authors.forename: Olfat
authors.initials: O
authors.lastname: Shaker
authors.forename: Safinaz S
authors.initials: SS
authors.lastname: Sayed
authors.forename: Dalia A
authors.initials: DA
authors.lastname: Abdel Halim
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D047495:PPAR gamma / Q000378:metabolism*; D011565:Psoriasis / Q000150:complications / Q000378:metabolism*; D012372:ROC Curve; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D047495:PPAR gamma