title: Usefulness of desensitization protocol for a carboplatin hypersensitivity reaction during docetaxel-carboplatin therapy for recurrent ovarian cancer: Case report.
abstract: We report a case of recurrent ovarian cancer in which desensitization for a carboplatin hypersensitivity reaction proved useful. The patient was a 65-year-old woman who presented with a recurrence of stage IIIc ovarian cancer. The initial chemotherapy consisted of 6 courses of paclitaxel and carboplatin. Recurrence in the pelvis, splenic hilum and para-aortic lymph nodes was detected 19 months after the final day of treatment. The patient was treated with docetaxel-carboplatin therapy for the recurrence, but a Grade 3 hypersensitivity reaction to carboplatin was observed during the second course. Carboplatin desensitization was commenced with the third course and 6 courses were completed with no evidence of hypersensitivity reaction. The antitumor effect showed a complete response and the patient has had a disease-free survival thus far. Desensitization for patients diagnosed with a carboplatin hypersensitivity reaction appeared to be a key method of treatment for prolonging the survival time of patients with recurrent ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 020-8505, Japan.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Shoji
authors.forename: Eriko
authors.initials: E
authors.lastname: Takatori
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kaido
authors.forename: Seisuke
authors.initials: S
authors.lastname: Kumagai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshizaki
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama