title: Semisynthetic peptide-lipase conjugates for improved biotransformations.
abstract: An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.
authors.affiliation: Departamento de Biocatálisis, Instituto de Catálisis (CSIC), Marie Curie 2, Cantoblanco, CampusUAM, 28049 Madrid, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Romero
authors.forename: Marco
authors.initials: M
authors.lastname: Filice
authors.forename: Blanca
authors.initials: B
authors.lastname: de las Rivas
authors.forename: Cesar
authors.initials: C
authors.lastname: Carrasco-Lopez
authors.forename: Javier
authors.initials: J
authors.lastname: Klett
authors.forename: Antonio
authors.initials: A
authors.lastname: Morreale
authors.forename: Juan A
authors.initials: JA
authors.lastname: Hermoso
authors.forename: Jose M
authors.initials: JM
authors.lastname: Guisan
authors.forename: Olga
authors.initials: O
authors.lastname: Abian
authors.forename: Jose M
authors.initials: JM
authors.lastname: Palomo
mesh_terms: D000595:Amino Acid Sequence; D001711:Biotransformation; D015195:Drug Design; D056506:Geobacillus / Q000201:enzymology; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D009842:Oligopeptides; D008049:Lipase