title: Blooming of Irganox 3114® antioxidant onto a medical grade elastomer. Impact of the recrystallization conditions on the antioxidant polymorphism, on the film wettability and on the antioxidant leachability.
abstract: Studying the blooming and recrystallization of additives onto the surface of polymer medical devices is of a great interest because it can affect the biocompatibility of the material. The polymorphism of a phenolic antioxidant (Irganox 3114(®)) used as an additive in medical devices and pharmaceutical packaging was studied: two different polymorphs were characterized by differential scanning measurements, FTIR and X-ray diffraction analyses. Then, the behavior of the additive in medical grade polyurethane films was described: a recrystallization into the stable polymorphic form was observed onto the polymer surface after annealing at different temperatures. The morphology observed depends not only on the additive/polymer ratio but also on the whole amount of additive in the polymer film. Depending on the recrystallization morphology, the wettability with water could be lowered and the leachability of the additives into aqueous media could be favored.
authors.affiliation: Laboratoire Matériaux et santé, EA 401, UFR de pharmacie, Université Paris-Sud 11, 5, rue JB Clément, 92296 Châtenay Malabry, France. Johanna.saunier@u-psud.fr
authors.forename: J
authors.initials: J
authors.lastname: Saunier
authors.forename: V
authors.initials: V
authors.lastname: Mazel
authors.forename: C
authors.initials: C
authors.lastname: Aymes-Chodur
authors.forename: N
authors.initials: N
authors.lastname: Yagoubi
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002084:Butylated Hydroxytoluene / Q000031:analogs & derivatives* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D011140:Polyurethanes / Q000737:chemistry*; D033362:Powder Diffraction; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D000975:Antioxidants; C547465:Irganox 3114; D011140:Polyurethanes; C059617:pellethane 2363-55D; D002084:Butylated Hydroxytoluene