title: [Taste-masking possibilities in solid dosage forms].
abstract: Increasing number of new, innovative pharmaceutical products are in the generic market. One of the important dosage forms is the group of orally disintegrating products. The feature of these products is that they disintegrate rapidly in the mouth upon contact with the saliva; therefore the dissolution of the water-soluble components begins in the mouth. Since a large part of the drug molecules is characterised by a more or less bitter taste, even a small amount of the dissolved drug can cause an unpleasant taste in the mouth. Manufacturers apply different techniques to mask the bitter taste of these products, depending on the characteristics of the dosage form and the bioavailability requirements. In this study, we reviewed the most widespread taste-masking methods based on the scientific literature and different patents and the characteristics of some important excipients, and outline an instrumental technique used for bitterness measurements.
authors.affiliation: Semmelweis Egyetem, Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet 1092 Budapest, Hőgyes E. u. 7-9.
authors.forename: Gergely
authors.initials: G
authors.lastname: Szakonyi
authors.forename: Romána
authors.initials: R
authors.lastname: Zelkó
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D005079:Excipients / Q000008:administration & dosage; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000494:pharmacology; D011145:Polyvinyls / Q000008:administration & dosage / Q000494:pharmacology; D013649:Taste; D013650:Taste Buds / Q000187:drug effects*; D055697:Taste Perception; D013678:Technology, Pharmaceutical / Q000379:methods*; D014280:Triglycerides / Q000008:administration & dosage
chemical_list: D005079:Excipients; D005227:Fatty Acids; C519734:Kollicoat IR; D004364:Pharmaceutical Preparations; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D014280:Triglycerides; C117135:kollicoat MAE 30 D; C086409:glyceryl behenate; C038300:methylmethacrylate-methacrylic acid copolymer; C013215:polyvinyl acetate; C005859:tripalmitin