title: BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients.
abstract: OBJECTIVE
  The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.
  
  
  METHODS
  We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.
  
  
  RESULTS
  We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ERα+ and ERα- breast cancer tissues, Mann-Whitney U test was performed, obtaining significant differences.
  
  
  CONCLUSIONS
  BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.
authors.affiliation: Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN S-XXI), Instituto Mexicano del Seguro Social (IMSS), Mexico D.F., Mexico. astridkaryme2001@yahoo.com.mx
authors.forename: Eunice
authors.initials: E
authors.lastname: López-Muñoz
authors.forename: Adelina
authors.initials: A
authors.lastname: Hernández-Zarco
authors.forename: Normand
authors.initials: N
authors.lastname: García-Hernández
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.forename: Gelasio
authors.initials: G
authors.lastname: Zarco-Espinosa
authors.forename: Fabio
authors.initials: F
authors.lastname: Salamanca-Gómez
authors.forename: Diego
authors.initials: D
authors.lastname: Arenas-Aranda
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D024101:Mitochondrial Proteins; D011237:Predictive Value of Tests
chemical_list: D051017:Apoptosis Regulatory Proteins; C096820:BIK protein, human; D014408:Biomarkers, Tumor; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D008565:Membrane Proteins; D024101:Mitochondrial Proteins