title: Serial high-sensitivity troponin measurements for the rapid exclusion of acute myocardial infarction in low-risk patients.
abstract: High-sensitivity troponin assays facilitate the rapid exclusion of acute myocardial infarction (AMI). However, elevated results are also seen in other conditions causing myocardial injury. Serial measurements increase the specificity for AMI, helping to rapidly identify patients for whom revascularisation may be appropriate. In this study, we explore a strategy for rapidly excluding AMI in symptomatic patients using serial high-sensitivity troponin measurements.
  
  
  RESULTS
  (1) all patients presenting more than 3 h after symptom onset with a negative result had a second negative result; (2) AMI was excluded in all patients with two results falling below the lower limit of detection of a standard troponin assay by 8 h post-symptom onset.
authors.affiliation: Department of Clinical Biochemistry, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dawson
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Benger
authors.forename: Graham
authors.initials: G
authors.lastname: Bayly
mesh_terms: D000208:Acute Disease; D001681:Biological Assay / Q000379:methods*; D015415:Biomarkers / Q000097:blood*; D002984:Clinical Laboratory Information Systems; D042241:Early Diagnosis; D004636:Emergency Service, Hospital; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013997:Time Factors; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D019210:Troponin I; D020107:Troponin T