title: A new highly versatile handle for chemistry on a solid support: the pipecolic linker.
abstract: The versatility of the pipecolic linker (Pip-linker) is illustrated by the synthesis of modified amino acids, C-terminal-modified pseudopeptides, and cyclic peptides, through side-chain anchoring of a lysine residue (see figure). Introduction of the first residue was easily accomplished and the Pip-linker revealed to be robust enough to support various chemical modifications.
authors.affiliation: Institut des Biomolécules Max Mousseron IBMM, UMR CNRS 5247, 15 avenue Charles Flahault, 34000 Montpellier, France. nicolas.masurier@univ-montp1.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Masurier
authors.forename: Paweł
authors.initials: P
authors.lastname: Zajdel
authors.forename: Pascal
authors.initials: P
authors.lastname: Verdié
authors.forename: Maciej
authors.initials: M
authors.lastname: Pawłowski
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Gilles
authors.initials: G
authors.lastname: Subra
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010455:Peptides