title: Treatment of granulomatous amoebic encephalitis with voriconazole and miltefosine in an immunocompetent soldier.
abstract: A 38-year-old male immunocompetent soldier developed generalized seizures. He underwent surgical debulking and a progressive demyelinating pseudotumor was identified. Serology and molecular testing confirmed a diagnosis of granulomatous amoebic encephalitis caused by Acanthamoeba sp. in this immunocompetent male. The patient was treated with oral voriconazole and miltefosine with Acanthamoeba titers returning to control levels and serial imaging demonstrating resolution of the residual lesion.
authors.affiliation: Department of Internal Medicine, Saint John Regional Hospital, Saint John, New Brunswick, Canada. Duncan.Webster@HorizonNB.ca
authors.forename: Duncan
authors.initials: D
authors.lastname: Webster
authors.forename: Imran
authors.initials: I
authors.lastname: Umar
authors.forename: Imram
authors.initials: I
authors.lastname: Umar
authors.forename: George
authors.initials: G
authors.lastname: Kolyvas
authors.forename: Juan
authors.initials: J
authors.lastname: Bilbao
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Guiot
authors.forename: Kevin
authors.initials: K
authors.lastname: Duplisea
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Qvarnstrom
authors.forename: Govinda S
authors.initials: GS
authors.lastname: Visvesvara
mesh_terms: D000048:Acanthamoeba / Q000187:drug effects* / Q000302:isolation & purification; D000328:Adult; D000562:Amebiasis / Q000188:drug therapy* / Q000469:parasitology; D000818:Animals; D004660:Encephalitis / Q000188:drug therapy* / Q000469:parasitology; D006099:Granuloma / Q000188:drug therapy* / Q000469:parasitology; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008889:Military Personnel; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D010767:Phosphorylcholine; C039128:miltefosine; D065819:Voriconazole