title: A mouse model to identify cooperating signaling pathways in cancer.
abstract: We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
authors.affiliation: Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
authors.forename: Monica
authors.initials: M
authors.lastname: Musteanu
authors.forename: Leander
authors.initials: L
authors.lastname: Blaas
authors.forename: Rainer
authors.initials: R
authors.lastname: Zenz
authors.forename: Jasmin
authors.initials: J
authors.lastname: Svinka
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoffmann
authors.forename: Beatrice
authors.initials: B
authors.lastname: Grabner
authors.forename: Daniel
authors.initials: D
authors.lastname: Schramek
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Kantner
authors.forename: Mathias
authors.initials: M
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Kolbe
authors.forename: Thomas
authors.initials: T
authors.lastname: Rülicke
authors.forename: Richard
authors.initials: R
authors.lastname: Moriggl
authors.forename: Lukas
authors.initials: L
authors.lastname: Kenner
authors.forename: Dagmar
authors.initials: D
authors.lastname: Stoiber
authors.forename: Josef Martin
authors.initials: JM
authors.lastname: Penninger
authors.forename: Helmut
authors.initials: H
authors.lastname: Popper
authors.forename: Emilio
authors.initials: E
authors.lastname: Casanova
authors.forename: Robert
authors.initials: R
authors.lastname: Eferl
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015689:Oncogene Protein p21(ras) / Q000235:genetics / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D015689:Oncogene Protein p21(ras)