title: Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
abstract: To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, UK. amorris@well.ox.ac.uk
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mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005796:Genes / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D012737:Sex Factors