title: A case of chronic hepatitis C with nephrotic diabetic nephropathy who achieved sustained viral remission by double-filtration plasmapheresis and interferon combination therapy.
abstract: We report a 66-year-old man with chronic hepatitis caused by hepatitis type C virus of genotype-1b and high-viral-load combined with cryoglobulinemia and advanced diabetic nephropathy in whom we successfully achieved viral removal and eradication by DFPP (VRAD). The dose of PEG-interferon was reduced to 70 mg/week due to thrombocytopenia. Rivavirin was discontinued at day 21 due to anemia. Even with treatment of PEG-interferon alone, the condition was judged to be sustained viral remission at the end of the observation. This is a successful report of VRAD in a combined case of diabetic and HCV-related cryoglobulin-nephropathy with nephrotic syndrome. The therapeutic effect of IFN seemed to be efficiently enhanced by concomitant DFPP (VRAD therapy).
authors.affiliation: Division of Nephrology, Kanazawa Medical University School of Medicine, Japan. hiroshi@kanazawa-med.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okuyama
authors.forename: Syogo
authors.initials: S
authors.lastname: Kimura
authors.forename: Keiji
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Junko
authors.initials: J
authors.lastname: Imura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Chikazawa
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamaya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003928:Diabetic Nephropathies / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000628:therapy* / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D010956:Plasmapheresis / Q000379:methods; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000008:administration & dosage; D012074:Remission Induction; D012254:Ribavirin / Q000008:administration & dosage; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a