title: Malondialdehyde and sulfhydryl groups as biomarkers of oxidative stress in patients with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin associated with oxidative stress. The present study aimed to investigate the presence of oxidative stress in patients with newly diagnosed SLE. SLE patients (n = 36) and control subjects (n = 28) were enrolled in this study. Blood samples were used for malondialdehyde (MDA), sulfhydryl groups (SH) and uric acid determination. MDA levels (µmol/L) were higher in patients (3.9 ± 2.6) than in control subjects (1.6 ± 2.6). SH were significantly lower in SLE patients. The findings suggest that MDA can be a good marker of oxidative stress in SLE.
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Manaus, AM, Brazil.
authors.forename: Yenly G
authors.initials: YG
authors.lastname: Pérez
authors.forename: Lissett Caridad González
authors.initials: LC
authors.lastname: Pérez
authors.forename: Rita de Cássia M
authors.initials: Rde C
authors.lastname: Netto
authors.forename: Domingos S N de
authors.initials: DS
authors.lastname: Lima
authors.forename: Emerson S
authors.initials: ES
authors.lastname: Lima
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D015415:Biomarkers; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde