title: A clinicopathologic study of Ki-67 proliferation index in colorectal carcinoma.
abstract: OBJECTIVE
  To investigate Ki-67 immunoexpressions in colorectal cancer and analyze possible correlations with variable clinicopathological prognostic factors.
  
  
  METHODS
  A cross-sectional study of tissue sections from 50 formalin-fixed and paraffin-embedded tumor specimens were examined at the Histopathology Laboratory of Rezgary Teaching Hospital in Erbil, Iraq between January 2010 and July 2011. Ki-67 labeling index is calculated immunohistochemically using the monoclonal antibody MIB-1, and the standard streptavidin-biotin immunoperoxidase method. The clinicopathologic and prognostic features were statistically analyzed.
  
  
  RESULTS
  Over-expression of Ki-67 proliferation protein was found in 31 (62%) cases. Statistical analyses revealed a significant relation between Ki-67 proliferation index and histologic type (p=0.005) and tumor grade (p=0.018); but no significant relation was calculated with the other clinicopathological parameters such as age, gender, tumor's size, site, depth, stage, nodal status, and vascular invasion (p>0.05).
  
  
  CONCLUSIONS
  Ki-67 immune overexpression is a frequent finding in our colorectal cancer cases; but it is not enough to monitor Ki-67 proliferation index alone for prognosis in colorectal cancer.
authors.affiliation: Department of Pathology, College of Medicine, Hawler Medical University, Erbil, Iraq. Tel +964 (66) 2273382. Fax. +964 (66) 2273382. E-mail: nadyaya@yahoo.com.
authors.forename: Nadya Y
authors.initials: NY
authors.lastname: Ahmed
authors.forename: Ava T
authors.initials: AT
authors.lastname: Ismail
authors.forename: Tayeb S
authors.initials: TS
authors.lastname: Kareem
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen