title: Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele.
abstract: OBJECTIVE
  Epidemiologic evidence demonstrates that heavy drinking increases the risk of stroke. However, whether recent heavy drinking affects the incidence of acute stroke in nonalcoholic individuals with the variant allele ALDH2*2 has not been reported.
  
  
  METHODS
  Two previously nonalcoholic healthy men suffered from acute ischemic stroke after a single episode of binge drinking. Both patients had one risk factor for stroke (a history of hypertension) and were heterozygous for ALDH2*2. CONCULUSION: The confluence of these factors with stroke has raised the possibility that heavy binge drinking increases the risk of acute stroke in hypertensives with the variant ALDH2*2 gene allele.
authors.affiliation: Department of Nursing, Chang Gung University of Science and Technology, Taoyuan.
authors.forename: Ching-Long
authors.initials: CL
authors.lastname: Lai
authors.forename: Meng-Ta
authors.initials: MT
authors.lastname: Liu
authors.forename: Shih-Jiun
authors.initials: SJ
authors.lastname: Yin
authors.forename: Jiunn-Tay
authors.initials: JT
authors.lastname: Lee
authors.forename: Chun-Chung
authors.initials: CC
authors.lastname: Lu
authors.forename: Giia-Sheun
authors.initials: GS
authors.lastname: Peng
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D063425:Binge Drinking / Q000150:complications* / Q000453:epidemiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000235:genetics*
chemical_list: C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial