title: The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study.
abstract: OBJECTIVE
  We aimed to evaluate the association between serum lipocalin-2 level and clinical and metabolic parameters in obese children.
  
  
  METHODS
  The study included obese children with a body mass index (BMI) >95th percentile who presented to Kecioren Teaching and Research Hospital with the complaint of weight gain and healthy children with a BMI <85th percentile. The height and weight of the patients were measured for compartment of anthropometric data. Fasting blood glucose, insulin, lipid profile, and serum lipocalin-2 level were measured to evaluate the laboratory parameters.
  
  
  RESULTS
  The study included 33 obese and 34 healthy nonobese children. Comparison of data on the obese subjects with those of the healthy subjects shows differences in BMI, BMI-SDS, triglyceride, insulin, and homeostasis model assessment index-insulin resistance levels between the two groups were statistically significant (p < 0.05), whereas serum lipocalin-2 was not statistically significant (p >0.05). There was no statistically significant difference in serum lipocalin-2 levels when obese and control groups were reclassified as prepubertal and pubertal ( p >0.05).
  
  
  CONCLUSIONS
  In this study, we did not find any relationships among serum lipocalin-2 level, anthropometric parameters, or metabolic parameters. According to the results of this study, we do not suggest routine investigation of serum lipocalin-2 level in obese subjects for risk stratification of the obesity-related complications.
authors.affiliation: Department of Pediatrics, Kecioren Teaching and Research Hospital, Ankara, Turkey. akelma@gmail.com
authors.forename: Ahmet Zulfikar
authors.initials: AZ
authors.lastname: Akelma
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abaci
authors.forename: Osman
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Aydin
authors.initials: A
authors.lastname: Celik
authors.forename: Zekai
authors.initials: Z
authors.lastname: Avci
authors.forename: Cem Hasan
authors.initials: CH
authors.lastname: Razi
authors.forename: Samil
authors.initials: S
authors.lastname: Hizli
authors.forename: Okhan
authors.initials: O
authors.lastname: Akin
mesh_terms: D000209:Acute-Phase Proteins; D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008050:Lipid A / Q000097:blood; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology*; D010865:Pilot Projects; D011518:Proto-Oncogene Proteins / Q000097:blood*; D012307:Risk Factors
chemical_list: D000209:Acute-Phase Proteins; D001786:Blood Glucose; C489506:LCN2 protein, human; D008050:Lipid A; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins