title: The addictive brain: all roads lead to dopamine.
abstract: This article will touch on theories, scientific research and conjecture about the evolutionary genetics of the brain function and the impact of genetic variants called polymorphisms on drug-seeking behavior. It will cover the neurological basis of pleasure-seeking and addiction, which affects multitudes in a global atmosphere where people are seeking "pleasure states".
authors.affiliation: Department of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL 32610-3424, USA. drd2gene@aol.com
authors.forename: Kenneth
authors.initials: K
authors.lastname: Blum
authors.forename: Amanda L C
authors.initials: AL
authors.lastname: Chen
authors.forename: John
authors.initials: J
authors.lastname: Giordano
authors.forename: Joan
authors.initials: J
authors.lastname: Borsten
authors.forename: Thomas J H
authors.initials: TJ
authors.lastname: Chen
authors.forename: Mary
authors.initials: M
authors.lastname: Hauser
authors.forename: Thomas
authors.initials: T
authors.lastname: Simpatico
authors.forename: John
authors.initials: J
authors.lastname: Femino
authors.forename: Eric R
authors.initials: ER
authors.lastname: Braverman
authors.forename: Debmalya
authors.initials: D
authors.lastname: Barh
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics / Q000378:metabolism* / Q000523:psychology / Q000534:rehabilitation; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D006801:Humans; D057181:Pleasure; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics; D019966:Substance-Related Disorders / Q000235:genetics / Q000378:metabolism* / Q000523:psychology / Q000534:rehabilitation
chemical_list: D017448:Receptors, Dopamine D2; D004298:Dopamine