title: Useable diffraction data from a multiple microdomain-containing crystal of Ascaris suum As-p18 fatty-acid-binding protein using a microfocus beamline.
abstract: As-p18 is a fatty-acid-binding protein from the parasitic nematode Ascaris suum. Although it exhibits sequence similarity to mammalian intracellular fatty-acid-binding proteins, it contains features that are unique to nematodes. Crystals were obtained, but initial diffraction data analysis revealed that they were composed of a number of `microdomains'. Interpretable data could only be collected using a microfocus beamline with a beam size of 12 × 8 µm.
authors.affiliation: Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland. mgabr@chem.gla.ac.uk
authors.forename: Mads
authors.initials: M
authors.lastname: Gabrielsen
authors.forename: Alan
authors.initials: A
authors.lastname: Riboldi-Tunnicliffe
authors.forename: Marina
authors.initials: M
authors.lastname: Ibáñez-Shimabukuro
authors.forename: Kate
authors.initials: K
authors.lastname: Griffiths
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Roe
authors.forename: Alan
authors.initials: A
authors.lastname: Cooper
authors.forename: Brian O
authors.initials: BO
authors.lastname: Smith
authors.forename: Betina
authors.initials: B
authors.lastname: Córsico
authors.forename: Malcolm W
authors.initials: MW
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D017165:Ascaris suum / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000295:instrumentation / Q000379:methods; D050556:Fatty Acid-Binding Proteins / Q000737:chemistry*
chemical_list: D050556:Fatty Acid-Binding Proteins