title: Cancer chemopreventive and therapeutic potential of guggulsterone.
abstract: Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms. It has anti-inflammatory and antioxidative properties and has recently attracted substantial attention due to its cancer chemopreventive and therapeutic potential exemplified by its antiproliferative, antimetastatic, and proapoptotic properties in many cancer cell lines and animal models. This review highlights some of the cancer chemopreventive/therapeutic targets of GS and the underlying molecular mechanisms.
authors.affiliation: Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea.
authors.forename: Inas
authors.initials: I
authors.lastname: Almazari
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D011282:Pregnenediones / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D011282:Pregnenediones; C023617:pregna-4,17-diene-3,16-dione