title: Unmasking of periodic limb movements with the resolution of obstructive sleep apnea during continuous positive airway pressure application.
abstract: OBJECTIVE
  Periodic limb movements (PLMs) and obstructive sleep apnea (OSA) may present as overlapping conditions. This study investigated the occurrence of PLM during continuous positive airway pressure (CPAP) titration, with the hypothesis that the presence of PLM during CPAP represented "unmasking" of a coexisting sleep disorder.
  
  
  METHODS
  A total of 78 polysomnographic recordings in 39 OSA subjects with an hourly PLM index ≥5 during CPAP application were evaluated.
  
  
  RESULTS
  Application of CPAP significantly improved sleep architecture without change in the PLM index when compared with baseline. The PLM indices and PLM arousal indices were linearly correlated during both nights (r = 0.553, P < 0.01; r = 0.548, P < 0.01, respectively). Eleven subjects with low PLM indices at baseline had greater changes in the PLM index as compared with the sample remainder (P = 0.004). Sixteen subjects with significantly lower PLM indices at baseline required optimal CPAP levels higher than the sample average of 8.2 cm H2O (P = 0.032). These subjects also showed significantly higher median apnea-hypopnea index (AHI) at baseline than the sample remainder (74.4 events per hour [range: 24.2-124.4 events per hour] vs. 22.7 events per hour [range: 8.6-77.4 events per hour], respectively, P < 0.001).
  
  
  CONCLUSIONS
  These findings suggest that PLM seen during CPAP titration may be related to a concurrent sleep disorder because of "unmasking" in patients with treated OSA.
authors.affiliation: Barnard College of Columbia University, New York, New York, USA.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Hedli
authors.forename: Paul
authors.initials: P
authors.lastname: Christos
authors.forename: Ana C
authors.initials: AC
authors.lastname: Krieger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020189:Nocturnal Myoclonus Syndrome / Q000175:diagnosis*; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult