title: Photodynamic activity of viral nanoparticles conjugated with C60.
abstract: The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C(60)) and their photodynamic activity is described. VNP-C(60) conjugates were assembled using click chemistry. Cell uptake and cell killing using white light therapy and a prostate cancer cell line is demonstrated.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Wen
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Ryan
authors.forename: Alice C
authors.initials: AC
authors.lastname: Yang
authors.forename: Kurt
authors.initials: K
authors.lastname: Breitenkamp
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pokorski
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Steinmetz
mesh_terms: D045744:Cell Line, Tumor; D057930:Click Chemistry; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D014780:Viruses / Q000737:chemistry*
chemical_list: D037741:Fullerenes; D017319:Photosensitizing Agents; C069837:fullerene C60