title: Hepatoprotective and anti-hepatitis C viral activity of Platycodon grandiflorum extract on carbon tetrachloride-induced acute hepatic injury in mice.
abstract: The present study aims to evaluate the anti-HCV activity of hotwater extract from Platycodon grandiflorum (BC703) with HCV genotype 1b subgenomic replicon system and investigate its hepatoprotective activity on carbon tetrachloride (CCl(4))-induced acute liver damage in mice. BC703 produced significant hepatoprotective effects against CCl(4)-induced acute hepatic injury by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation. Histopathological studies further substantiated the protective effect of BC703. Furthermore, BC703 inhibited the HCV RNA replication with an EC(50) value and selective index (CC(50)/EC(50)) of 2.82 µg/mL and above 35.46, respectively. However, digested BC703 using a simulated gastric juice showed poor protective effect against CCl(4)-induced hepatotoxicity in mice and decreased anti-HCV activity as compared to the intact BC703. Although further studies are necessary, BC703 may be a beneficial agent for the management of acute hepatic injury and chronic HCV infection.
authors.affiliation: College of Veterinary Medicine, Chungnam National University, Daejeon, South of Korea.
authors.forename: Tae-Won
authors.initials: TW
authors.lastname: Kim
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: In-Bae
authors.initials: IB
authors.lastname: Song
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Yang
authors.forename: Jung Cheul
authors.initials: JC
authors.lastname: Shin
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Suh
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Son
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Cho
authors.forename: Myoung-Seok
authors.initials: MS
authors.lastname: Kim
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Jong-Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000517:prevention & control; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D031238:Platycodon / Q000737:chemistry*
chemical_list: D010936:Plant Extracts