title: [Successful use of danaparoid in the treatment of portal vein thrombosis that developed in a warfarin-administered hepatitis C virus-related cirrhosis patient].
abstract: An 84-year-old woman with hepatitis C virus-related cirrhosis, hepatocellular carcinoma and atrial fibrillation, who presented with hematemesis, was initially treated with endoscopic variceal ligation (EVL) for an esophageal varix hemorrhage. However, computed tomography (CT) upon admission had revealed portal vein thrombosis, despite having received warfarin for existing atrial fibrillation. We subsequently initiated a 2-week treatment with danaparoid;warfarin being discontinued in order to reduce the risk of re-hemorrhage. A follow-up CT after treatment revealed complete reduction of the portal vein thrombosis. This is the first successful report of danaparoid use in the treatment of portal vein thrombosis that developed in a patient who had received warfarin.
authors.affiliation: Department of Gastroenterology, Southern-Tohoku Hospital, Japan. hakata.x@gmail.com
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nawata
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hamada
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tajima
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nishino
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Tobayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Saitoh
mesh_terms: D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003871:Dermatan Sulfate / Q000627:therapeutic use*; D005260:Female; D006497:Heparan Sulfate / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D011169:Portal Vein; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006497:Heparan Sulfate; D014859:Warfarin; C035838:danaparoid