title: [New processing procedure for Croton tiglium with study on comparison of Croton tiglium and processed product].
abstract: OBJECTIVE
  To build a new processing procedure for Croton tiglium, providing a more simple, efficient and safe way of processing.
  
  
  METHODS
  Used the contents of isoguanosine and toxic protein in Croton tiglium as the indexes to investigate the effect of different temperature, thickness and baked time on processing for Croton tiglium. After established all factors and levels, processed a batch of Croton tiglium under optimum processing conditions and compared it with raw Croton tiglium in the test of acute toxicity and gastrointestinal propulsive motility.
  
  
  RESULTS
  The parameters of optimum processing were as follows:the temperature was set at 180 degrees C, the thickness of placement was 3 cm and baked time was 90 min. The LD50 value of raw Croton tiglium and the processed Croton tiglium was 888 mg/kg and 2139 mg/kg respectively.
  
  
  CONCLUSIONS
  The processing procedure is simple, affordable, safe and efficient, deserved to promote for application.
authors.affiliation: Research Institute of Mathematical Engineering of Guangzhou University of Chinese Medicine, Dongguan 523808, China. zb-101@tom.com
authors.forename: Bao
authors.initials: B
authors.lastname: Zeng
authors.forename: Meng-Qiu
authors.initials: MQ
authors.lastname: Huang
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Tang
authors.forename: Zu-Ping
authors.initials: ZP
authors.lastname: Xiao
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Jiang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Lai
mesh_terms: D000241:Adenosine; D000818:Animals; D029802:Croton / Q000737:chemistry; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006151:Guanosine / Q000032:analysis; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010940:Plant Proteins / Q000032:analysis; D012639:Seeds / Q000737:chemistry* / Q000633:toxicity; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D010936:Plant Extracts; D010940:Plant Proteins; D006151:Guanosine; C008184:isoguanosine; D000241:Adenosine