title: Primary ovarian rhabdomyosarcoma in a dog.
abstract: A 10-year-old female English pointer was diagnosed with an ovarian tumour with abdominal metastases. Ultrasonography revealed several nodules of 1-5 cm diameter within the abdominal cavity. Fine needle aspiration cytology of the nodules suggested a malignant mesenchymal tumour. On necropsy examination the right ovary and its capsule were enlarged and there were white-red, friable nodular masses distributed over the surface of the pancreas, liver, omentum, mesentery and serosae of the small and large intestines. Microscopical evaluation revealed neoplastic cells with a high degree of pleomorphism and vascular invasion. Immunohistochemically, the neoplastic cells expressed myosin, desmin, vimentin and CD10, but were negative for cytokeratin, placental alkaline phosphatase, inhibin-alpha and smooth muscle actin. Based on these findings a diagnosis of primary ovarian alveolar rhabdomyosarcoma was made.
authors.affiliation: Laboratório de Patologia do, Departamento de Clínica e Cirurgia da Escola de Veterinária, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
authors.forename: J N
authors.initials: JN
authors.lastname: Boeloni
authors.forename: A M S
authors.initials: AM
authors.lastname: Reis
authors.forename: E F
authors.initials: EF
authors.lastname: Nascimento
authors.forename: J F
authors.initials: JF
authors.lastname: Silva
authors.forename: R
authors.initials: R
authors.lastname: Serakides
authors.forename: N M
authors.initials: NM
authors.lastname: Ocarino
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism; D004285:Dogs; D005260:Female; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012208:Rhabdomyosarcoma / Q000378:metabolism / Q000556:secondary / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor