title: [Manganese in atherogenesis: detection, origin, and role].
abstract: The role of transition metal ions in atherogenesis is controversial; they can participate in the hydroxyl radical generation and catalyze the reactive oxygen species neutralization reaction as cofactors of antioxidant enzymes. Using EPR spectroscopy, we revealed that 70% of the samples of aorta with atherosclerotic lesions possessed superoxide dismutase activity, 100% of the samples initiated Fenton reaction and demonstrated the presence of manganese paramagnetic centers. The sodA gene encoding manganese-dependent bacterial superoxide dismutase was not found in the samples of atherosclerotic plaques by PCR using degenerate primers. The data obtained indicates the perspectives of manganese analysis as a marker element in the express diagnostics of atherosclerosis.
authors.forename: A P
authors.initials: AP
authors.lastname: Lozhkin
authors.forename: T B
authors.initials: TB
authors.lastname: Biktagirov
authors.forename: V A
authors.initials: VA
authors.lastname: Abdul'ianov
authors.forename: O V
authors.initials: OV
authors.lastname: Gorshkov
authors.forename: E V
authors.initials: EV
authors.lastname: Timonina
authors.forename: G V
authors.initials: GV
authors.lastname: Mamin
authors.forename: S B
authors.initials: SB
authors.lastname: Orlinskiĭ
authors.forename: N I
authors.initials: NI
authors.lastname: Silkin
authors.forename: V M
authors.initials: VM
authors.lastname: Chernov
authors.forename: R N
authors.initials: RN
authors.lastname: Khaĭrullin
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Salakhov
authors.forename: O N
authors.initials: ON
authors.lastname: Il'inskaia
mesh_terms: D001011:Aorta / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics; D015415:Biomarkers / Q000032:analysis; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008345:Manganese / Q000032:analysis* / Q000502:physiology*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D015415:Biomarkers; D008345:Manganese; C095500:SodA protein, Bacteria; D013482:Superoxide Dismutase