title: Progression of vascular calcification is increased with statin use in the Veterans Affairs Diabetes Trial (VADT).
abstract: OBJECTIVE
  To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).
  
  
  METHODS
  Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM.
  
  
  RESULTS
  After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean ± SE, 8.2 ± 0.5 mm(3) vs. 4.2 ± 1.1 mm(3); P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users.
  
  
  CONCLUSIONS
  More frequent statin use is associated with accelerated CAC in T2DM patients with advanced atherosclerosis.
authors.affiliation: Phoenix VA Health Care System, Phoenix, AZ, USA. aramesh.saremi@va.gov
authors.forename: Aramesh
authors.initials: A
authors.lastname: Saremi
authors.forename: Gideon
authors.initials: G
authors.lastname: Bahn
authors.forename: Peter D
authors.initials: PD
authors.lastname: Reaven
mesh_terms: D000368:Aged; D001018:Aortic Diseases / Q000139:chemically induced*; D003324:Coronary Artery Disease / Q000139:chemically induced*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D061205:Vascular Calcification / Q000139:chemically induced*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors