title: Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies.
abstract: We report the first prospective study describing the prevalence and clinical consequences of norovirus infection in hospitalized children with primary immunodeficiencies. Fecal samples from 62 children were systematically screened for virus. Norovirus was the most frequent pathogen (11 of 24 positive samples) found in both combined and humoral immunocompromised children. Norovirus shedding was associated with gastrointestinal symptoms and concomitant viremia in 54.5% and 25% of cases, respectively. Norovirus excretion was prolonged: 57.1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies.
authors.affiliation: Unité d'Immunologie, Hématologie et Rhumatologie Pédiatriques, AP-HP, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France. pierre.frange@nck.aphp.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Frange
authors.forename: Fabien
authors.initials: F
authors.lastname: Touzot
authors.forename: Marianne
authors.initials: M
authors.lastname: Debré
authors.forename: Sébastien
authors.initials: S
authors.lastname: Héritier
authors.forename: Marianne
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: Guilhem
authors.initials: G
authors.lastname: Cros
authors.forename: Christine
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Véronique
authors.initials: V
authors.lastname: Avettand-Fenoël
mesh_terms: D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000821:virology*; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology; D006761:Hospitals; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000151:congenital*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D029322:Norovirus / Q000302:isolation & purification*; D015995:Prevalence; D011446:Prospective Studies; D014766:Viremia / Q000453:epidemiology / Q000821:virology; D017201:Virus Shedding