title: Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men.
abstract: Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.
authors.affiliation: Lund University Diabetes Center, Inga-Marie Nilssons gata 53 floor 3, 205 02, Malmö, Sweden. erik.renstrom@med.lu.se.
authors.forename: E
authors.initials: E
authors.lastname: Renström
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000473:pathology* / Q000502:physiology*; D010179:Pancreas / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein / Q000172:deficiency* / Q000235:genetics*
chemical_list: D007328:Insulin; C544894:TCF7L2 protein, human; C544895:Tcf7l2 protein, mouse; D058118:Transcription Factor 7-Like 2 Protein; D005947:Glucose