title: Analytical and numerical approaches to coexistence of strains in a two-strain SIS model with diffusion.
abstract: This article introduces a two-strain spatially explicit SIS epidemic model with space-dependent transmission parameters. We define reproduction numbers of the two strains, and show that the disease-free equilibrium will be globally stable if both reproduction numbers are below one. We also introduce the invasion numbers of the two strains which determine the ability of each strain to invade the single-strain equilibrium of the other strain. The main question that we address is whether the presence of spatial structure would allow the two strains to coexist, as the corresponding spatially homogeneous model leads to competitive exclusion. We show analytically that if both invasion numbers are larger than one, then there is a coexistence equilibrium. We devise a finite element numerical method to numerically confirm the stability of the coexistence equilibrium and investigate various competition scenarios between the strains. Finally, we show that the numerical scheme preserves the positive cone and converges of first order in the time variable and second order in the space variables.
authors.affiliation: Department of Mathematics, University of Florida, 358 Little Hall, PO Box 118105, Gainesville, FL 32611-8105, USA.
authors.forename: Necibe
authors.initials: N
authors.lastname: Tuncer
authors.forename: Maia
authors.initials: M
authors.lastname: Martcheva
mesh_terms: D050936:Basic Reproduction Number; D004058:Diffusion; D004198:Disease Susceptibility; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D013997:Time Factors