title: Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue.
abstract: Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine.
authors.affiliation: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Krausova
authors.forename: V
authors.initials: V
authors.lastname: Korinek
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D066246:ErbB Receptors / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007414:Intestinal Neoplasms / Q000209:etiology*; D036081:Receptors, Eph Family / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology
chemical_list: D053823:Hedgehog Proteins; D051880:Receptors, Notch; D066246:ErbB Receptors; D036081:Receptors, Eph Family