title: Age effects on serotonin receptor 1B as assessed by PET.
abstract: Previous imaging studies have suggested that there is an age-related decline in brain serotonin (5-hydroxytryptamine) measures in healthy subjects. This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT(1B)) is seen to decrease with aging via PET imaging.
  
  
  METHODS
  Forty-eight healthy control subjects (mean age ± SD, 30 ± 10 y; age range, 18-61 y; 33 men, 15 women) underwent (11)C-P943 scanning on a high-resolution PET tomograph. Regions were examined with and without gray matter masking, the latter in an attempt to control for age-related gray matter atrophy on nondisplaceable binding potential (BP(ND)) as determined by a validated multilinear reference tissue model.
  
  
  RESULTS
  5-HT(1B) BP(ND) decreased in the cortex at an average rate of 8% per decade without and 9% with gray matter masking. A negative association with age was also observed in all individual cortical regions. Differences in the putamen and pallidum (positive association) were significant after adjustment for multiple comparisons. No sex- or race-related effects on 5-HT(1B) BP(ND) were found in any regions.
  
  
  CONCLUSIONS
  These findings indicate that age is a relevant factor for 5-HT(1B) in the cortex of healthy adults.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA. david.matuskey@yale.edu
authors.forename: David
authors.initials: D
authors.lastname: Matuskey
authors.forename: Brian
authors.initials: B
authors.lastname: Pittman
authors.forename: Beata
authors.initials: B
authors.lastname: Planeta-Wilson
authors.forename: Espen
authors.initials: E
authors.lastname: Walderhaug
authors.forename: Shannan
authors.initials: S
authors.lastname: Henry
authors.forename: Jean-Dominique
authors.initials: JD
authors.lastname: Gallezot
authors.forename: Nabeel
authors.initials: N
authors.lastname: Nabulsi
authors.forename: Yu-Shin
authors.initials: YS
authors.lastname: Ding
authors.forename: Zubin
authors.initials: Z
authors.lastname: Bhagwagar
authors.forename: Robert
authors.initials: R
authors.lastname: Malison
authors.forename: Richard E
authors.initials: RE
authors.lastname: Carson
authors.forename: Alexander
authors.initials: A
authors.lastname: Neumeister
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000378:metabolism; D049268:Positron-Emission Tomography; D011760:Pyrrolidinones / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D013379:Substrate Specificity; D055815:Young Adult
chemical_list: C546827:1-(4-(2-methoxyisopropyl)phenyl)-3-(2-(4-methylpiperazin-1-yl)benzyl)pyrrolidin-2-one; D002250:Carbon Radioisotopes; D008024:Ligands; D010879:Piperazines; D011760:Pyrrolidinones; D044302:Receptor, Serotonin, 5-HT1B