title: Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain.
abstract: There are eleven families of phosphodiesterases that regulate cellular levels of cyclic nucleotides by degradation of cAMP or cGMP. Knowledge of the expression sites of different PDE genes in brain is of special importance for studies on development of specific inhibitors considering that, for example, PDE4 inhibitor treatments exhibit profound anti-inflammatory effects. To address possible species differences we examined the expression of mRNAs coding for the cAMP specific PDE4 and PDE7 families since inhibitors have been used in clinic for schizophrenia, mood disorders, cognition and inflammatory diseases treatment. We have compared the expression of these PDEs in mouse brain by in situ hybridization histochemistry in comparison with rat brain and found that their neuroanatomical distribution differs in a few areas.
authors.affiliation: Departament de Neuroquímica i Neurofarmacologia, Institut d'Investigacions Biomèdiques de Barcelona (CSIC), IDIBAPS, CIBERNED, Rosselló 161, 08036 Barcelona, Spain.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Johansson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Reyes-Irisarri
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Mengod
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000235:genetics / Q000378:metabolism*; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7 / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity
chemical_list: D007527:Isoenzymes; D012333:RNA, Messenger; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7