title: Rh-catalyzed intermolecular carbenoid functionalization of aromatic C-H bonds by α-diazomalonates.
abstract: A Rh-catalyzed intermolecular coupling of diazomalonates with arene C-H bonds is reported. The reaction is initiated by electrophilic C-H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to α-aryl carbonyl compounds for specific applications.
authors.affiliation: State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Wai-Wing
authors.initials: WW
authors.lastname: Chan
authors.forename: Siu-Fung
authors.initials: SF
authors.lastname: Lo
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu