title: A preliminary study about the effects of warm priming solution on oxidative stress and postoperative atrial fibrillation in open heart surgery.
abstract: BACKGROUND
  An important reason for production of ischemia and reperfusion injury and oxidative stress is the sudden and rapid changes in body temperature during the institution of cardiopulmonary bypass. The aim of this study was to investigate the effects of warm priming solution on oxidative stress and atrial fibrillation.
  
  
  METHODS
  This is a preliminary prospective study on a group of 40 patients who underwent elective coronary artery bypass grafting operation using cardiopulmonary bypass. Patients were randomized into two groups, each consisting of 20 patients; one group was primed with a solution at 20 °C and the other at 36 °C initially for cardiopulmonary bypass. Blood samples from both of the groups were drawn preoperatively and at the 15th and 60th min of aortic cross clamping and 24th h following the surgery. Serum malondialdehyde levels, protein carbonyl content and total antioxidant status were detected. Patients were followed for postoperative atrial fibrillation.
  
  
  RESULTS
  Malondialdehyde and protein carbonyl content were found to be significantly higher and total antioxidant status was concordantly lower in the cold priming group at the 15th and 60th min, recovering to the normal range postoperatively at the 24th h. Patients in the cold priming group had developed a significantly higher rate of atrial fibrillation when compared with the patients in the warm priming group during the postoperative period.
  
  
  CONCLUSIONS
  In conclusion, although this study has its limitation about the sample size it may provide an insight about the probable preventive effects of 36 °C warm priming solution in oxidative stress and postoperative atrial fibrillation.
authors.affiliation: Department of Cardiovascular Surgery, School of Medicine, Zonguldak Karaelmas University, 67600, Kozlu-Zonguldak, Turkey. mustafabuyukates@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Buyukates
authors.forename: Serefden
authors.initials: S
authors.lastname: Acikgoz
authors.forename: Erol
authors.initials: E
authors.lastname: Aktunc
authors.forename: Ozer
authors.initials: O
authors.lastname: Kandemir
authors.forename: Sait Mesut
authors.initials: SM
authors.lastname: Dogan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology* / Q000503:physiopathology* / Q000517:prevention & control; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010865:Pilot Projects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012996:Solutions; D016896:Treatment Outcome
chemical_list: D017382:Reactive Oxygen Species; D012996:Solutions