title: A new concept in the sewing rings for mechanical heart valves.
abstract: BACKGROUND
  Valve-associated complications challenge the quality of life and longevity after heart valve replacement. Inappropriate healing may be a contributing factor.
  
  
  OBJECTIVE
  To evaluate a new design mechanical heart valve in an animal model.
  
  
  RESULTS
  The new valve was fabricated by substituting the sewing ring with an inbuilt suture ridge and an overlying fabric flap. It improved the effective orifice area. Animal experiments were performed on pigs to compare this valve with standard valve models. The animals were kept on dual antiplatelet drugs. Six of the 8 test animals survived the observation period of 140 days compared to 2 of the 6 controls. Among the test valves, one had thrombosis and 3 had significant tissue hyperplasia, whereas 5 control valves had thrombosis associated with significant tissue hyperplasia. Three test valves had paravalvular defects compared to none in the control group. Histology showed good tissue incorporation of the fabric flap of the test valves, whereas the control valves had tissue infiltration limited to the peripheral fabric layer of the sewing ring.
  
  
  CONCLUSIONS
  The new valve has improved effective orifice area, and the animal study showed better survival, good healing, and a lower incidence of thrombosis and tissue hyperplasia.
authors.affiliation: Institute of Cardiovascular Diseases, Madras Medical Mission, 4A-Dr. JJ Nagar, Mogappair, Chennai 600 037, India. kurian1974@gmail.com
authors.forename: Mathew V
authors.initials: MV
authors.lastname: Kurian
authors.forename: Payanam R
authors.initials: PR
authors.lastname: Umasankar
authors.forename: Arumugam
authors.initials: A
authors.lastname: Sabareeswaran
authors.forename: Sachin J
authors.initials: SJ
authors.lastname: Shenoy
authors.forename: Vijayakumar
authors.initials: V
authors.lastname: Subban
authors.forename: Mathew K
authors.initials: MK
authors.lastname: Joseph
mesh_terms: D000818:Animals; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D008297:Male; D011474:Prosthesis Design; D013537:Sutures; D013552:Swine