title: Flecainide and antiarrhythmic effects in a mouse model of catecholaminergic polymorphic ventricular tachycardia.
abstract: Recent studies have shown that flecainide may be an effective therapy to prevent life-threatening arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Several hypotheses have been advanced to explain the antiarrhythmic mechanism of flecainide, including Na(+) channel blockade and a direct inhibitory action on the ryanodine receptor. In this article, we review the current literature on the topic and summarize the elements of the existing debate.
authors.affiliation: Cardiovascular Genetic Program, The Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Nian
authors.initials: N
authors.lastname: Liu
authors.forename: Carlo
authors.initials: C
authors.lastname: Napolitano
authors.forename: Luigi A
authors.initials: LA
authors.lastname: Venetucci
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Priori
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002395:Catecholamines; D004195:Disease Models, Animal; D005424:Flecainide / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D032383:Myocytes, Cardiac / Q000187:drug effects*; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000517:prevention & control; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
chemical_list: D000889:Anti-Arrhythmia Agents; D002395:Catecholamines; D005424:Flecainide