title: Effects of a chitosan intake on the fecal excretion of dioxins and fat in rats.
abstract: We evaluated the effects of the intake of various dietary fibers on the fecal excretion of dioxins in rats. The rats were fed five types of dietary fiber diets, including a chitosan diet and control diet, for 20 d and then dioxins (120 ng/rat) were orally administered on day 15. The excretion of fecal dioxins was significantly higher in the chitosan group than in the control group, and dioxin excretion was positively correlated with fecal fat excretion. A comparison of the different types of chitosan showed that the efficacy of chitosan for fecal fat excretion was partly related to its viscosity. The chitosan intake promoted fecal dioxin excretion when the rats were exposed to highly toxic dioxins, and this excretion of fecal dioxins was related to the fecal fat excretion, suggesting that chitosan might be useful for reducing the adverse effects caused by lipophilic xenobiotics.
authors.affiliation: Otsu Nutraceuticals Research Institute, Nutraceuticals Division, Otsuka Pharmaceutical Co., Ltd., Shiga 520-0002, Japan. Kohda.Noriyuki@otsuka.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kohda
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Inoue
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Noda
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
mesh_terms: D000818:Animals; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D004147:Dioxins / Q000633:toxicity*; D005223:Fats / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D005526:Food, Formulated; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014783:Viscosity
chemical_list: D004043:Dietary Fiber; D004147:Dioxins; D005223:Fats; D048271:Chitosan