title: Genetic variation in GSTM1 is associated with susceptibility to noise-induced hearing loss in a Chinese population.
abstract: OBJECTIVE
  To investigate whether glutathione S-transferases (GST) genetic polymorphisms (GSTT1 rs1049055, GSTM1 rs10712361, and GSTP1 rs1695) are associated with susceptibility to noise-induced hearing loss (NIHL).
  
  
  METHODS
  These polymorphisms were analyzed in 444 NIHL and 445 normal hearing workers. In addition, total plasma GST activity was measured in all subjects.
  
  
  RESULTS
  Individuals with the GSTM1 null genotype had a statistically significantly increased risk of NIHL (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.26 to 2.13) compared with those carrying a wild-type GSTM1 genotype. This effect was more pronounced among the workers exposed to 86 to 91 dB(A) (OR = 3.35, 95% CI = 1.54 to 7.31). Glutathione S-transferase activity of the NIHL workers was also lower than that of normal hearing workers (14.5 ± 5.1 U/ml vs 15.9 ± 6.3 U/ml, P = 0.010).
  
  
  CONCLUSIONS
  Our results suggest that GSTM1 polymorphism is associated with susceptibility to NIHL.
authors.affiliation: Department of Occupational Medicine and Environmental Health, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
authors.forename: Huanxi
authors.initials: H
authors.lastname: Shen
authors.forename: Xinying
authors.initials: X
authors.lastname: Huo
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Xiuting
authors.initials: X
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Hengdong
authors.initials: H
authors.lastname: Zhang
authors.forename: Yanqiong
authors.initials: Y
authors.lastname: Xu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhu
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D051549:Glutathione S-Transferase pi / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects; D011110:Polymorphism, Genetic
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human