title: [Morphological changes of the intestine in experimental acute intestinal infection in the treatment of colloidal silver].
abstract: At the present stage of infectionist practice in the treatment of acute intestinal infections caused by opportunistic microorganisms, colloidal silver is used with a particle size of 25 nm as an alternative to conventional causal therapy. In 32 rats, distributed in 4 groups of 8 animals each (intact; healthy, got colloidal silver; with a modeled acute intestinal infection in the basic treatment and with the addition of colloidal silver), histological examination was performed of small and large intestine of rats. Oral administration of colloidal silver at a dose of 0.02 mg/day to intact rats did not lead to changes in morphometric parameters compared to the norm, and during early convalescence in rats with acute intestinal infections were observed destructive and compensatory changes in the intestine, which depended on the treatment regimen. With the introduction of colloidal silver decreased activity of the inflammatory process and the severity of morphological changes in tissues of small and large intestine, indicating that the positive effect of study drug compared with baseline therapy.
authors.forename: E S
authors.initials: ES
authors.lastname: Polov'ian
authors.forename: N D
authors.initials: ND
authors.lastname: Chemich
authors.forename: R A
authors.initials: RA
authors.lastname: Moskalenko
authors.forename: A N
authors.initials: AN
authors.lastname: Romaniuk
mesh_terms: D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D003102:Colloids / Q000008:administration & dosage* / Q000009:adverse effects; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000382:microbiology; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology; D010316:Particle Size; D051381:Rats; D012834:Silver / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D003102:Colloids; D012834:Silver