title: [Aortic valve stenosis is associated with reduced myocardial perfusion as assessed by videodensitometry in coronary angiograms].
abstract: Aortic valve stenosis may be accompanied by angina despite coronary arteries free of significant stenosis due to microvascular abnormalities.
  
  
  OBJECTIVE
  The aim of the current study was to test whether densitometry-derived myocardial perfusion on coronary angiogram is reduced in patients with aortic valve stenosis.
  
  
  METHODS
  The study comprised 20 patients with aortic valve stenosis (mean transvalvular gradient: 47.4±15.2 mm Hg) and 30 control subjects without significant epicardial coronary artery stenosis. A quantitative parameter of myocardial perfusion was calculated by the ratio of maximal density (Gmax) and time to reach maximum density (Tmax) on time-density curves in regions of interest of each coronary artery on coronary angiograms.
  
  
  RESULTS
  Mean three-vessel Gmax/Tmax proved to be significantly lower in patients with aortic valve stenosis compared to control subjects (2.55±1.02 1/sec vs. 3.39±1.09 1/sec, p<0.01).
  
  
  CONCLUSIONS
  Reduced Gmax/Tmax values indicative of myocardial perfusion abnormalities as measured by densitometry on coronary angiograms could be demonstrated in patients with aortic valve stenosis compared to controls.
authors.affiliation: Szegedi Tudományegyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika és Kardiológiai Központ, Invazív Kardiológiai Részleg és Hemodinamikai Laboratórium Szeged Korányi fasor 6. 6720.
authors.forename: Ferenc Tamás
authors.initials: FT
authors.lastname: Nagy
authors.forename: Tamás
authors.initials: T
authors.lastname: Horváth
authors.forename: Tamás
authors.initials: T
authors.lastname: Ungi
authors.forename: Viktor
authors.initials: V
authors.lastname: Sasi
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Zimmermann
authors.forename: Anita
authors.initials: A
authors.lastname: Kalapos
authors.forename: Tamás
authors.initials: T
authors.lastname: Forster
authors.forename: Imre
authors.initials: I
authors.lastname: Ungi
authors.forename: Attila
authors.initials: A
authors.lastname: Nemes
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015986:Confounding Factors, Epidemiologic; D017023:Coronary Angiography / Q000379:methods; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000150:complications* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012107:Research Design; D014057:Tomography, X-Ray Computed