title: A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata.
abstract: From the methanol extract of the stem bark of Ficus exasperata, a new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2',3'-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, (S)-(-) oxypeucedanin hydrate (2), (R)-(+) oxypeucedanin hydrate (3), bergapten (5-methoxypsoralen) and six other known compounds, were isolated. Their structures were characterized basing on spectroscopic methods and chemical evidence. Compounds (1-3) were analyzed for their antimicrobial activity. Ficusamide (1) showed wick activity (minimal inhibitory concentration (MIC)=312.5 µg/mL) against Escherichia coli, while the furanocoumarins (2) and (3) showed significant activity (MIC=9.76 µg/mL) against Bacillus cereus, Candida albicans and Microsporum audouinii.
authors.affiliation: Laboratoire de Produits Naturels et de Synthèse des Hétérocycles, Département de Chimie Organique de l'Université de Yaoundé-1, Faculté des Sciences, P.O. Box 812 Yaoundé, Cameroun.
authors.forename: Marlise Diane Jiofack
authors.initials: MD
authors.lastname: Dongfack
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lallemand
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Céline Djama
authors.initials: CD
authors.lastname: Mbazoa
authors.forename: Jean-Duplex
authors.initials: JD
authors.lastname: Wansi
authors.forename: Hanh
authors.initials: H
authors.lastname: Trinh-van-Dufat
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.forename: Jean
authors.initials: J
authors.lastname: Wandji
mesh_terms: D001409:Bacillus cereus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D030681:Ficus / Q000737:chemistry*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013107:Sphingolipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D011564:Furocoumarins; D010936:Plant Extracts; D013107:Sphingolipids