title: Early life hypoxic or hypoxic/hypercapnic stress alters acute ventilatory sensitivity in adult mice.
abstract: In this study we investigated the effect of early life conditioning (hypoxia ± hypercapnia) on adult acute ventilatory sensitivity to hypoxia and hypercapnia. Mice were exposed to either hypoxia (5% O(2)) or hypoxia/hypercapnia (5% O(2)/8% CO(2)) in a normobaric chamber for 2 h at postnatal day 2 (P2), and then returned to normoxia. At 3 months of age, hypoxic ventilatory response (HVR) and hypercapnic ventilatory response (HCVR) were measured using a plethysmograph system. Results showed that HVR was significantly decreased in the P2-hypoxia mice but not in the P2 hypoxia/hypercapnia mice as compared to the P2-normoxic mice, respectively. However, HCVR was significantly decreased in the P2 hypoxia-hypercapnia group but not in the P2-hypoxia group. These data suggest early postnatal hypoxic stress vs. hypoxic/hypercapnic stress plays different roles in fetal programming of the respiratory control system as shown by altered adult acute ventilatory sensitivity.
authors.affiliation: Departments of Neurology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Robbins E732, Cleveland, OH, USA. kxx@case.edu.
authors.forename: Kui
authors.initials: K
authors.lastname: Xu
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Solomon Raju
authors.initials: SR
authors.lastname: Bhupanapadu Sunkesula
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Pengjing
authors.initials: P
authors.lastname: Huang
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Constantinos P
authors.initials: CP
authors.lastname: Tsipis
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Radford
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Gerald
authors.initials: G
authors.lastname: Babcock
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Walter F
authors.initials: WF
authors.lastname: Boron
authors.affiliation: Departments of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: LaManna
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D051379:Mice; D010991:Plethysmography; D012123:Pulmonary Ventilation / Q000502:physiology*