title: Comparison of vitamin D deficiency and secondary hyperparathyroidism in obese and non-obese children and adolescents.
abstract: Obesity subjects individuals into metabolic and endocrine disorders. Thus obesity may increase the risk of vitamin D deficiency. This text aims at studying the prevalence of vitamin D deficiency and secondary hyperparathyroidism in obese children. In a non-randomized case control study on 52 obese children (body mass index (BMI) >95th percentile) aged 4 to 16 years undertaken at the outpatient endocrine clinic of the Children Hospital at Tabriz University between 2009-2011. This study was conducted to compare the prevalence of vitamin D deficiency and secondary hyperparathyroidism in obese children compared with 57 non obese (BMI < 85th percentile). 109 children including 52 (50.5%) boys and 57 (49.5%) girls were studied. Most of case (76.9%) and control (42.1%) groups suffered from degrees of vitamin D deficiency. There was meaningful statistical difference between two groups considering to vitamin D deficiency and parathyroid hormone (p = 0.001). A negative relations was found between iPTH and vit D level (p < 0.001, r = -0.2), BMI and 25-OH vit D (p < 0.001, r = -0.2). A positive relation was observed between parathyroid hormone and BMI (p = 0.009, r = 0.1). Obese children are at high risk at vitamin D deficiency and secondary hyperparathyroidism. BMI appears to be an important risk factor for vitamin D deficiency.
authors.affiliation: Department of Pediatrics Endocrinology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Robabeh
authors.initials: R
authors.lastname: Ghergherechi
authors.forename: Nazanin
authors.initials: N
authors.lastname: Hazhir
authors.forename: Ali
authors.initials: A
authors.lastname: Tabrizi
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000175:diagnosis; D007492:Iran; D008297:Male; D009765:Obesity / Q000150:complications*; D015995:Prevalence; D012306:Risk; D012307:Risk Factors; D014808:Vitamin D Deficiency / Q000097:blood*