title: The emerging application of remote ischemic conditioning in the clinical arena.
abstract: Remote ischemic conditioning (RIC) is an intervention, in which intermittent episodes of ischemia and reperfusion in an organ or tissue distant from the target organ requiring protection, provide armour against lethal ischemia-reperfusion injury. Although the exact mechanisms underlying the protection mediated through RIC have not been clearly established, the release of humoral factors and the activation of neural pathways have been implicated. There is now clinical evidence suggesting that this form of protection can be induced by a simple, noninvasive, and cost-effective procedure such as inflation and deflation of a blood pressure cuff and that this intervention provides increased organ protection in a variety of clinical scenarios, for example, in myocardial infarction. Here we provide an overview of the history and evolution of RIC, the potential mechanisms underlying its protective effects, and published randomized clinical trials in cardiovascular procedures.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Yetgin
authors.forename: Olivier C
authors.initials: OC
authors.lastname: Manintveld
authors.forename: Fahriye
authors.initials: F
authors.lastname: Groen
authors.forename: Buket
authors.initials: B
authors.lastname: Tas
authors.forename: Arie P
authors.initials: AP
authors.lastname: Kappetein
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Duncker
mesh_terms: D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000009:adverse effects* / Q000379:methods; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000150:complications* / Q000517:prevention & control; D013997:Time Factors