title: Hydronephrosis: a view from the inside.
abstract: Unilateral ureteropelvic junction obstruction (UPJO) is the most common prenatally detected disease leading to hydronephrosis. The obstructive anatomic lesion leads to varying degrees of hydronephrosis, ranging from no apparent effect on renal function to atrophy. Furthermore, the natural course of hydronephrosis varies from spontaneous resolution to progressive deterioration and may take upwards of 3 years for a kidney to declare itself. The objectives of this article are to update our knowledge regarding the evaluation and management of UPJO in depth and to discuss the emerging value of urinary proteome analysis to the clinical arena.
authors.affiliation: Division of Pediatric Urology, Department of Urology, Medical College and Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. hmesrobi@mcw.edu
authors.forename: Hrair-George O
authors.initials: HG
authors.lastname: Mesrobian
authors.forename: Shama P
authors.initials: SP
authors.lastname: Mirza
mesh_terms: D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis
chemical_list: D015415:Biomarkers