title: Serum biomarkers of neurologic injury in cardiac operations.
abstract: Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.
authors.affiliation: Faculty of Medicine, The University of Sydney, The Baird Institute, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Seco
authors.forename: J James B
authors.initials: JJ
authors.lastname: Edelman
authors.forename: Michael K
authors.initials: MK
authors.lastname: Wilson
authors.forename: Paul G
authors.initials: PG
authors.lastname: Bannon
authors.forename: Michael P
authors.initials: MP
authors.lastname: Vallely
mesh_terms: D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D003072:Cognition Disorders / Q000097:blood* / Q000209:etiology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood; D009422:Nervous System Diseases / Q000097:blood* / Q000209:etiology; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D009414:Nerve Growth Factors; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase