title: Anticoagulant, fibrinolytic, and hypoglycemic effects of tetrapeptide Arg-Pro-Gly-Pro.
abstract: It was found that 3-fold intranasal administration of Arg-Pro-Gly-Pro peptide in a dose of 1 mg/kg body weight under conditions of experimental persistent hyperglycemia prevents the development of diabetes in experimental rats and produces normoglycemic, anticoagulant, fibrinolytic, and antiplatelet effects.
authors.affiliation: Laboratory of Blood Defense Systems, Biological Faculty, MV Lomonosov State Moscow University, Russia. shubina.74@mail.ru
authors.forename: T A
authors.initials: TA
authors.lastname: Shubina
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: L A
authors.initials: LA
authors.lastname: Lyapina
authors.forename: A M
authors.initials: AM
authors.lastname: Ulyanov
authors.forename: T J
authors.initials: TJ
authors.lastname: Obergan
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000187:drug effects; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000925:Anticoagulants; C572888:Arg-Pro-Gly-Pro; D007004:Hypoglycemic Agents; D009842:Oligopeptides