title: Serial 3-dimensional computed tomography and a novel method of volumetric analysis for the evaluation of the osteo-odonto-keratoprosthesis.
abstract: OBJECTIVE
  To assess the use of serial computed tomography (CT) in the detection of osteo-odonto-lamina resorption in osteo-odonto-keratoprosthesis (OOKP) and to investigate the use of new volumetric software, Advanced Lung Analysis software (3D-ALA; GE Healthcare), for detecting changes in OOKP laminar volume.
  
  
  METHODS
  A retrospective assessment of the radiological databases and hospital records was performed for 22 OOKP patients treated at the National OOKP referral center in Brighton, United Kingdom. Three-dimensional surface reconstructions of the OOKP laminae were performed using stored CT data. For the 2-dimensional linear analysis, the linear dimensions of the reconstructed laminae were measured, compared with original measurements taken at the time of surgery, and then assigned a CT grade based on a predetermined resorption grading scale. The volumetric analysis involved calculating the laminar volumes using 3D-ALA. The effectiveness of 2-dimensional linear analysis, volumetric analysis, and clinical examination in detecting laminar resorption was compared.
  
  
  RESULTS
  The mean change in laminar volume between the first and second scans was -6.67% (range, +10.13% to -24.86%). CT grades assigned to patients based on laminar dimension measurements remained the same, despite significant changes in laminar volumes. Clinical examination failed to identify 60% of patients who were found to have resorption on volumetric analysis.
  
  
  CONCLUSIONS
  Currently, the detection of laminar resorption relies on clinical examination and the measurement of laminar dimensions on the 2- and 3-dimensional radiological images. Laminar volume measurement is a useful new addition to the armamentarium. It provides an objective tool that allows for a precise and reproducible assessment of laminar resorption.
authors.affiliation: Sussex Eye Hospital, Brighton, United Kingdom.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Sipkova
authors.forename: Fook Chang
authors.initials: FC
authors.lastname: Lam
authors.forename: Ian
authors.initials: I
authors.lastname: Francis
authors.forename: Jim
authors.initials: J
authors.lastname: Herold
authors.forename: Christopher
authors.initials: C
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000175:diagnosis / Q000209:etiology; D001862:Bone Resorption / Q000175:diagnosis*; D003316:Corneal Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014092:Tooth Root / Q000637:transplantation*; D055815:Young Adult