title: Coupling of methyl ketones and primary or secondary amines leading to α-ketoamides.
abstract: A metal-free oxidative coupling of methyl ketones and primary or secondary amines to α-ketoamides has been developed. Four intermediates, α-iodoketone, α-aminoketone, iminium intermediate, and α-hydroxy amine have been identified through a series of control experiments. The atom-economic methodology can be scaled-up, tolerates a variety of functional groups, and is operationally simple.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.forename: Huayou
authors.initials: H
authors.lastname: Hu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines; D007659:Ketones