title: Specific 5-hydroxylation of piperlongumine by Beauveria bassiana ATCC 7159.
abstract: A new hydroxylated derivative was efficiently prepared by transforming the natural anti-cancer product, piperlongumine, with Beauveria bassiana ATCC 7159. Its structure was determined to be 5-hydroxylpiperlongumine on the basis of the spectroscopic data. The absolute configuration at C-5 was established as R by Mosher's method.
authors.affiliation: Department of Biological Engineering, Utah State University, 4105 Old Main Hill, Logan, UT 84322-4105, USA.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zi
authors.forename: S Gabrielle
authors.initials: SG
authors.lastname: Gladstone
authors.forename: Jixun
authors.initials: J
authors.lastname: Zhan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000378:metabolism*; D052982:Beauveria / Q000378:metabolism*; D001711:Biotransformation; D004148:Dioxolanes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010881:Piperidones
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004148:Dioxolanes; C577908:5-hydroxylpiperlongumine; C498077:piperlongumine; D010881:Piperidones