title: The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns.
abstract: Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.
authors.affiliation: University of Rijeka, Rijeka University Hospital Center, Department of Perinatology, Clinic for Gynecology, Croatia. alenka7@net.hr
authors.forename: Alenka Vukelić
authors.initials: AV
authors.lastname: Sarunić
authors.forename: Olga
authors.initials: O
authors.lastname: Cvijanović
authors.forename: Luka
authors.initials: L
authors.lastname: Dudarić
authors.forename: Branko
authors.initials: B
authors.lastname: Denona
authors.forename: Lucian
authors.initials: L
authors.lastname: Vukelić
authors.forename: Dragica
authors.initials: D
authors.lastname: Bobinac
authors.forename: Aleks
authors.initials: A
authors.lastname: Finderle
mesh_terms: D000328:Adult; D000886:Anthropometry; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000453:epidemiology*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000453:epidemiology*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D019332:Endothelin-1