title: Photophysical probes to assess the potential of cholic acid aggregates as drug carriers.
abstract: The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid aggregates as drug carriers by means of photophysical techniques. The different distribution of the probes between bulk solution and aggregates has been assessed by quenching of their singlet and triplet excited states by iodide and nitrite anions, respectively. This straightforward photophysical methodology can, in principle, be extended to a variety of drugs containing a photoactive chromophore.
authors.affiliation: Instituto Universitario Mixto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València, Avenida de los Naranjos s/n, 46022 Valencia, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gomez-Mendoza
authors.forename: Edurne
authors.initials: E
authors.lastname: Nuin
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Andreu
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Marin
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Miranda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry; D055668:Photochemical Processes; D020358:Sodium Cholate / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D009288:Naproxen; D020358:Sodium Cholate