title: Health related quality of life in Mexican women with systemic lupus erythematosus: a descriptive study using SF-36 and LupusQoL(C).
abstract: The LupusQoL© questionnaire is a disease-specific health related quality of life (HRQOL) instrument for adults with systemic lupus erythematosus (SLE). The Short Form-36 (SF-36) is a generic instrument that captures the physical, psychological, and social impact. We conducted a descriptive study of women aged ≥ 18 years attending our Lupus Clinic. HRQOL was assessed by applying the LupusQoL© and SF-36. Lupus activity was measured using the Mexican Systemic Lupus Erythematosus Disease Activity Index (Mex-SLEDAI) and chronic damage using the Systemic Lupus Collaborative Clinics Damage Index (SDI). Data were analyzed using descriptive statistics, the chi-square test and Pearson's product moment correlation coefficient. A total of 127 patients were included with a mean age of 40.5 ± 12.6 years. The mean disease duration was 8.2 ± 5.6 years, the mean disease activity score was 2.4 ± 3.0, and the mean SDI score 0.77 ± 1.06. The mean SF-36 score was 58.1 ± 21.1 and the mean LupusQoL© score was 69 ± 22.7. The correlation between global scores of the SF-36 and LupusQoL© was rho = 0.73 (p < 0.001). The correlation between lupus disease activity and the SF-36 and the LupusQoL© was -0.26 (p = 0.003) and -0.25 (p = 0.004), respectively. The correlation between the SDI and the SF-36 and the LupusQoL© was -0.28 (p = 0.001) and -0.38 (p < 0.0001), respectively. In conclusions: both LupusQoL© and SF-36 were useful instruments in assessing HRQOL in Mexican lupus female patients. The usefulness of the LupusQoL© should be evaluated in lupus patients with moderate to severe disease activity.
authors.affiliation: Systemic Autoimmune Diseases Research Unit, HGR 36 (Hospital General Regional 36) IMSS (Instituto Mexicano del Seguro Social), Mexico. mgc30591@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: García-Carrasco
authors.forename: C
authors.initials: C
authors.lastname: Mendoza-Pinto
authors.forename: M H
authors.initials: MH
authors.lastname: Cardiel
authors.forename: S
authors.initials: S
authors.lastname: Méndez-Martínez
authors.forename: A
authors.initials: A
authors.lastname: García-Villaseñor
authors.forename: C
authors.initials: C
authors.lastname: Jiménez-Hernández
authors.forename: N E
authors.initials: NE
authors.lastname: Alonso-García
authors.forename: R
authors.initials: R
authors.lastname: Briones-Rojas
authors.forename: G
authors.initials: G
authors.lastname: Ramos-Álvarez
authors.forename: A
authors.initials: A
authors.lastname: López-Colombo
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires