title: Tumor-infiltrating lymphocytes in melanoma.
abstract: Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is arguably the most effective treatment for patients with metastatic melanoma. With higher response rates than ipilimumab or IL-2, and longer durations of response than vemurafenib, TIL therapy carries the potential to transform current outcomes in melanoma, while also defining the way cell-based immunotherapy gets incorporated into mainstream cancer treatment. This paper will review the current state of TIL therapy in melanoma, the strategies to improve its efficacy, the current obstacles, and future directions to expand the availability of TIL to the general patient population.
authors.affiliation: Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, 98195, USA. smlee@fhcrc.org
authors.forename: Sylvia
authors.initials: S
authors.lastname: Lee
authors.forename: Kim
authors.initials: K
authors.lastname: Margolin
mesh_terms: D019264:Adoptive Transfer / Q000379:methods; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D018929:Cell Culture Techniques / Q000379:methods; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007376:Interleukin-2 / Q000627:therapeutic use; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000637:transplantation*; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D007376:Interleukin-2