title: Mass spectrometric approaches to study enveloped viruses: new possibilities for structural biology and prophylactic medicine.
abstract: This review considers principles of the use of mass spectrometry for the study of biological macromolecules. Some examples of protein identification, virion proteomics, testing vaccine preparations, and strain surveillance are represented. Possibilities of structural characterization of viral proteins and their posttranslational modifications are shown. The authors' studies by MALDI-MS on S-acylation of glycoproteins from various families of enveloped viruses and on oligomerization of the influenza virus hemagglutinin transmembrane domains are summarized.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. kord@belozersky.msu.ru
authors.forename: L V
authors.initials: LV
authors.lastname: Kordyukova
authors.forename: M V
authors.initials: MV
authors.lastname: Serebryakova
mesh_terms: D006023:Glycoproteins / Q000737:chemistry*; D011315:Preventive Medicine; D011487:Protein Conformation; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014759:Viral Envelope Proteins / Q000737:chemistry*; D014780:Viruses / Q000737:chemistry*
chemical_list: D006023:Glycoproteins; D014759:Viral Envelope Proteins