title: Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: associated with interstitial lung diseases.
abstract: OBJECTIVE
  To determine whether interleukin (IL)-27 is involved in dermatomyositis (DM) and polymyositis (PM).
  
  
  METHODS
  Serum IL-27, IL-18 and interferon-γ (IFN-γ) levels in 37 DM and 15 PM were detected by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum IL-27, IL-18 and IFN-γ levels were significantly higher in DM and PM patients than in healthy controls. Significant higher levels of IL-27 were found in high creatine kinase (CK) level group and in patients with interstitial lung disease (ILD). Level of IL-27 was correlated with global 100-mm visual analog scales (VASs) score in patients with PM.
  
  
  CONCLUSIONS
  These data supports the hypothesis that IL-27 maybe involved in DM and PM pathogenesis.
authors.affiliation: Department of Rheumatology, 1st Affiliated Hospital of China Medical University, Shen Yang 110001, China. shenhuicam@sohu.com
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Liping
authors.initials: L
authors.lastname: Xia
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000097:blood* / Q000150:complications* / Q000201:enzymology; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000150:complications* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010865:Pilot Projects; D017285:Polymyositis / Q000097:blood* / Q000150:complications* / Q000201:enzymology
chemical_list: D020382:Interleukin-18; D007378:Interleukins; C464565:MYDGF protein, human; D007371:Interferon-gamma; D003402:Creatine Kinase