title: Pregnancy and delivery outcomes following a pathological second trimester triple test screening result and a normal karyotype.
abstract: OBJECTIVE
  To investigate whether obstetrical complications are increased in pregnancies with a normal karyotype and an abnormal triple test (TT) (≥1:380 or more) where all analytes were within the normal range.
  
  
  METHODS
  A retrospective cohort study of women who underwent a TT and delivered in a tertiary medical center, was conducted. Patients were divided into a study group (pregnancies with abnormal TT) and a control group (normal TT). In both groups, the analyte concentrations were within the normal range and the karyotype was normal. Demographic and clinical characteristics, antenatal factors, gestational complications and perinatal outcomes were compared between the groups.
  
  
  RESULTS
  An abnormal TT result in the presence of normal analytes and a normal karyotype, had no impact on obstetrical complications. A direct association between elevated values of hCG within the normal range (0-2.0 MoM) and pathological TT was noticed (OR = 2.6, p < 0.01). On the other hand, an inverse correlation between elevation in AFP (0-2.0 MoM) and uE3 was found (OR < 0.01, p < 0.01; OR < 0.01, p < 0.01, respectively).
  
  
  CONCLUSIONS
  An abnormal TT result in the presence of normal analytes and a normal karyotype, had no influence on rate of obstetrical complications.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva Israel.
authors.forename: Adi Y
authors.initials: AY
authors.lastname: Weintraub
authors.forename: Inbal
authors.initials: I
authors.lastname: Weiss
authors.forename: Michael
authors.initials: M
authors.lastname: Friger
authors.forename: Reli
authors.initials: R
authors.lastname: Hershkovitz
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000097:blood; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D004964:Estriol / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D059785:Karyotype; D008403:Mass Screening / Q000706:statistics & numerical data; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000502:physiology; D011296:Prenatal Diagnosis / Q000706:statistics & numerical data; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol