title: Research from the bedside to the lab bench & back.
abstract: Transgenic mice represent a unique opportunity in biomedical research to discover the genes underlying disease and understand how manipulating the function of single genes and proteins alters physiology in a whole animal system. These advances in biomedical research may accelerate the time between when basic discoveries are made and when the research can be 'translated', that is, when the research will positively impact the lives of patients. The purpose of this article is to present some examples of promising mouse models of human diseases.
authors.affiliation: Department of Biochemistry, Kansas City University of Medicine and Biosciences, USA. jtolley@kcumb.edu
authors.forename: Robert A
authors.initials: RA
authors.lastname: White
authors.forename: Michael
authors.initials: M
authors.lastname: Silvey
authors.forename: Derek P
authors.initials: DP
authors.lastname: Logsdon
mesh_terms: D000740:Anemia / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D004195:Disease Models, Animal; D050982:GATA1 Transcription Factor; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics / Q000503:physiopathology; D013103:Spherocytosis, Hereditary / Q000235:genetics / Q000503:physiopathology; D057170:Translational Research, Biomedical
chemical_list: D050982:GATA1 Transcription Factor; C494689:Gata1 protein, mouse