title: [Genotypes distribution of hepatitis C virus through multi-center, large sample studies among chronic hepatitis C patients in Chinese Han population].
abstract: OBJECTIVE
  To understand the distribution of hepatitis C virus (HCV) genotypes in China.
  
  
  METHODS
  A national multi-center, large sample epidemiological survey was carried out and certified by an international third-party testing organization. Internationally accepted method for sequencing analysis of viral genotype was used.
  
  
  RESULTS
  Patients were those suffered from the 4 major genotypes of chronic hepatitis C, including nine subtypes, which were dominated by genotype 1 (69.6%), with type 1b in particular (accounting for 68.38%). Among the rare gene-6, we saw more subtypes of 6a. In the south, central, and north areas, there was no significant difference seen between the south and the north areas in the distribution of the genotype 1. However, the rate of gene type 2a increased gradually from south to north. In terms of less common type of gene 3b and gene-6, they were seen mainly in the southern provinces.
  
  
  CONCLUSIONS
  In China, Patients with chronic hepatitis C had 4 HCV genotypes, with 9 subtypes. The rarely seen genotypes 3b and 6 were mainly distributed in the southern provinces.
authors.affiliation: Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
authors.forename: Hong-ming
authors.initials: HM
authors.lastname: Nie
authors.forename: Jian-jie
authors.initials: JJ
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Cheng-bao
authors.initials: CB
authors.lastname: Wang
authors.forename: Hui-lin
authors.initials: HL
authors.lastname: Dong
authors.forename: Yi-yun
authors.initials: YY
authors.lastname: Chen
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018571:Sentinel Surveillance