title: Kidney injury molecule-1 as a promising biomarker for acute kidney injury in premature babies.
abstract: OBJECTIVE
  To evaluate the role of urinary kidney injury molecule-1 (uKIM-1) in early determination of renal injury in premature infants with respiratory distress syndrome (RDS).
  
  
  METHODS
  Forty-eight premature babies hospitalized in the neonatal intensive care unit were included in the study and divided into three groups: group I, healthy premature infants; group II, preterm infants with RDS without acute kidney injury (AKI); group III, preterm infants with RDS and AKI. uKIM-1 and creatinine along with serum creatinine levels were measured with enzyme-linked immunosorbent assay on days 1, 3, and 7 of life.
  
  
  RESULTS
  On day 1, uKIM-1 levels in babies with RDS and AKI were higher than the other two groups. In this group, a significant increase in uKIM-1 levels were detected on day 3 (p = 0.015). The sensitivity and specificity of uKIM-1 were calculated as 73.3% and 76.9%, respectively, along with the increase of 0.5 ng per milligram of creatinine of uKIM-1 in day 3, when compared with values on day 1. Elevated uKIM-1 on day 7 was found to increase the risk of death by 7.3 times.
  
  
  CONCLUSIONS
  Serial uKIM-1 measurements can be used as a noninvasive indicator of kidney injury and uKIM-1 can be an ideal biomarker in premature infants.
authors.affiliation: Department of Pediatric Nephrology, Ondokuz Mayis University Faculty of Medicine, Children's Hospital, Samsun, Turkey. gencdoc@yahoo.com
authors.forename: Gurkan
authors.initials: G
authors.lastname: Genc
authors.forename: Ozan
authors.initials: O
authors.lastname: Ozkaya
authors.forename: Bahattin
authors.initials: B
authors.lastname: Avci
authors.forename: Canan
authors.initials: C
authors.lastname: Aygun
authors.forename: Sukru
authors.initials: S
authors.lastname: Kucukoduk
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine*; D012372:ROC Curve; D011991:Receptors, Virus; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D003404:Creatinine