title: [The role of aldosterone and IL-6 in the pathogenesis of inflammation in familial Mediterranean fever].
abstract: The aim of the article was to study the role of aldosterone and IL-6 - in the pathogenesis of familial Mediterranean fever (FMF). The hypersecretion  of  IL-6 and "the syndrome of aldosterone excess" in patients with  FMF was revealed. The hyperactivity of the inflammatory process in FMF is one of the phenotypic factors of defective gene expression in FMF.   In the course of the development of familial Mediterranean fever in presence of amyloidosis, the inhibition of mineralocorticoid function, and constantly elevated IL-6 levels, which gradually progresses bringing to an exhaustion of that function and to the dissociation of the adaptative-regulatory homeostasis.  The given introduction enlarges view points of pathogenesis of FMF and confirms the multifactorial nature of FMF, in the development of which besides the genetic factors, has a great role of phenotypic factors, as well. From the phenotypic factors is hyperaldosteronemia, hyperinterleukinemia-6, which reacts with defective gene and promotes its expression, and brings to the development of FMF attacks.
authors.forename: Z T
authors.initials: ZT
authors.lastname: Dzhndoian
authors.forename: N G
authors.initials: NG
authors.lastname: Martirosian
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000686:Amyloidosis / Q000097:blood / Q000150:complications / Q000473:pathology; D003078:Colchicine / Q000008:administration & dosage; D010505:Familial Mediterranean Fever / Q000097:blood / Q000150:complications / Q000188:drug therapy; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged
chemical_list: D015850:Interleukin-6; D000450:Aldosterone; D003078:Colchicine