title: Cardiac P2X(4) receptors: targets in ischemia and heart failure?
abstract: Purinergic receptors have attracted growing interest as therapeutic targets. This perspective focuses on P2X(4) receptors as a new cardioprotective target in heart failure.
authors.affiliation: Calhoun Cardiovascular Center, University of Connecticut Health Center School of Medicine, Farmington, CT 06030, USA.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Yang
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Liang
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D058911:Purinergic P2X Receptor Agonists / Q000627:therapeutic use*; D058848:Receptors, Purinergic P2X4 / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D002317:Cardiovascular Agents; D058911:Purinergic P2X Receptor Agonists; D058848:Receptors, Purinergic P2X4; D000255:Adenosine Triphosphate