title: Preventative valve-sparing aortic root replacement and pregnancy outcome in Marfan syndrome.
abstract: In Marfan syndrome, with dilatation of the aortic root secondary to an underlying connective tissue defect, pregnancy can cause hemodynamic stress leading to the development of an aortic aneurysm and even a fatal aortic dissection. In the presence of existing aortic root enlargement and a family history of aortic dissection, preventative elective surgery is suggested. Aortic root replacement with or without a valve-sparing procedure is superior to total aortic root replacement with prosthetic valve/tube graft. It provides excellent survival with low rates of aortic - valve related complications.
authors.affiliation: University of Zagreb, Zagreb University Hospital Center, Department of Obstetrics and Gynaecology, Zagreb, Croatia. vesnasokol83@yahoo.com
authors.forename: Vesna
authors.initials: V
authors.lastname: Sokol
authors.forename: Gordan
authors.initials: G
authors.lastname: Zlopasa
authors.forename: Mislav
authors.initials: M
authors.lastname: Herman
authors.forename: Pavao
authors.initials: P
authors.lastname: Planinić
authors.forename: Ana
authors.initials: A
authors.lastname: Micevska
mesh_terms: D000328:Adult; D001011:Aorta / Q000601:surgery*; D001018:Aortic Diseases / Q000209:etiology / Q000601:surgery*; D001021:Aortic Valve / Q000601:surgery*; D005260:Female; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome