title: Kit formulation for 99mTc-labeling of HYNIC-βAla-Bombesin((7-14)).
abstract: Bombesin (BBN) is a tetradecapeptide that binds specifically to gastrin-releasing peptide receptors. Several forms of cancer, including lung, prostate, breast, and colon express receptors for bombesin-like peptides. Radiolabeled BBN analogs with a high affinity for these receptors might be used for scintigraphic imaging. Kit formulations for labeling these molecules are important for routine preparation. A freeze-dried kit for labeling HYNIC-βAla-Bombesin((7-14)) with technetium-99m was prepared, and its storage stability was evaluated by in vitro and in vivo assays.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: André Luís Branco
authors.initials: AL
authors.lastname: de Barros
authors.forename: Luciene das Graças
authors.initials: Ld
authors.lastname: Mota
authors.forename: Carolina de Aguiar
authors.initials: Cde A
authors.lastname: Ferreira
authors.forename: Valbert Nascimento
authors.initials: VN
authors.lastname: Cardoso
mesh_terms: D001839:Bombesin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D005612:Freeze Drying; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000737:chemistry*; D018004:Receptors, Bombesin / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D018004:Receptors, Bombesin; D001839:Bombesin