title: Metabolic syndrome and vascular risk estimation in a Mediterranean non-diabetic population without cardiovascular disease.
abstract: OBJECTIVE
  Vascular risk equations are tools used to help prevent cardiovascular events. Our aim was to compare the REGICOR and SCORE equations in a general population and in persons with the metabolic syndrome (MS) according to the criteria of the International Diabetes Federation.
  
  
  RESULTS
  We calculated the cardiovascular risk with both equations in a random sample of 838 non-diabetic persons aged 40-65years without a history of cardiovascular disease, of whom 251 had the MS. Of the 838 persons, 3.6% had a high risk according to SCORE and 1.5% according to REGICOR, and of these, 53.3% and 61.5%, respectively, had the MS. The mean risk was greater in the persons with the MS than those without (REGICOR 4.6% vs. 2.6% and SCORE 1.7% vs. 1%; p<0.01 for each). In comparison with the group without the MS, the percentage of persons with the MS who had a high risk was greater with both scales: REGICOR (3.2% vs. 0.8%, p=0.027) and SCORE (6.4% vs. 2.4%, p=0.004). The agreement (kappa index) classifying the subjects with a high risk, was 0.453 in the overall sample and 0.391 in the subgroup with the MS.
  
  
  CONCLUSIONS
  The percentage of persons classified as having a high cardiovascular risk differed between REGICOR and SCORE. Using these scales only a small percentage of non-diabetic persons with the MS have a high risk. The presence of the MS multiplies the percentage of non-diabetic persons with a high vascular risk two-fold with SCORE and four-fold with REGICOR.
authors.affiliation: Internal Medicine Department, Hospital Regional Universitario Carlos Haya, Malaga, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Jansen-Chaparro
authors.forename: Jose
authors.initials: J
authors.lastname: Mancera
authors.forename: Jose I
authors.initials: JI
authors.lastname: Cuende
authors.forename: Aurora
authors.initials: A
authors.lastname: Villalobos
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Baca
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Lopez-Carmona
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Bernal-Lopez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gomez-Huelgas
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology