title: [An experimental study of the cervical lymphatic imaging in interstitial magnetic resonance lymphography of tongue using Dextran-DTPA-Gd].
abstract: OBJECTIVE
  To explore the application value of the cervical lymphatic imaging in interstitial magnetic resonance lymphography using submucosal injection of Dextran-DTPA-Gd.
  
  
  METHODS
  0.2 mL Dextran-DTPA-Gd (3.96 mmol/L) was injected into the submucosa of the bilateral lingual margins in 12 New Zealand rabbits,and then massaged the injection site for 30 seconds. MR images were obtained before injection and 10, 15, 20, 25, 30, 35, 40, 50, 90 minutes after injection by 3D TOF CE-MRA sequence.The signal intensities of cervical lymph node were measured, the enhancing rates(E%) were calculated and the signal enhancing rates -time curve was drawn. The data was analysed using SPSS11.5 software package.
  
  
  RESULTS
  The cervical lymph nodes,the first and second lymphatics were strengthened significantly after injecting Dextran-DTPA-Gd, but the blood vessels were not enhanced at the same time. The enhancing rates of cervical lymph node reached the peak(344%) at 30-min,and the best strengthening effect was achieved between 20-min and 50-min.
  
  
  CONCLUSIONS
  As IMRLG contrast agent,the Dextran-DTPA-Gd could image lymphatic drainage lines of the neck and the cervical lymph nodes efficiently.
authors.affiliation: Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Medical College, Qingdao University, Shandong Province, China. zengfengw@163.com
authors.forename: Zeng-feng
authors.initials: ZF
authors.lastname: Wang
authors.forename: Yuan-yong
authors.initials: YY
authors.lastname: Feng
authors.forename: Shi-en
authors.initials: SE
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Sheng-biao
authors.initials: SB
authors.lastname: Wan
authors.forename: Wen-jian
authors.initials: WJ
authors.lastname: Xu
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Shang
mesh_terms: D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D019786:Gadolinium DTPA; D008198:Lymph Nodes; D008220:Lymphography; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009333:Neck; D011817:Rabbits
chemical_list: D003287:Contrast Media; D003911:Dextrans; D019786:Gadolinium DTPA