title: Treatment-independent miRNA signature in blood of Wilms tumor patients.
abstract: BACKGROUND
  Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001.
  
  
  RESULTS
  We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls.
  
  
  CONCLUSIONS
  Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of four weeks preoperative chemotherapy treatment.
authors.affiliation: Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany. jana.schmitt@uks.eu
authors.forename: Jana
authors.initials: J
authors.lastname: Schmitt
authors.forename: Christina
authors.initials: C
authors.lastname: Backes
authors.forename: Nasenien
authors.initials: N
authors.lastname: Nourkami-Tutdibi
authors.forename: Petra
authors.initials: P
authors.lastname: Leidinger
authors.forename: Stephanie
authors.initials: S
authors.lastname: Deutscher
authors.forename: Markus
authors.initials: M
authors.lastname: Beier
authors.forename: Manfred
authors.initials: M
authors.lastname: Gessler
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Lenhof
authors.forename: Andreas
authors.initials: A
authors.lastname: Keller
authors.forename: Eckart
authors.initials: E
authors.lastname: Meese
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D016000:Cluster Analysis; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D059467:Transcriptome / Q000187:drug effects*; D009396:Wilms Tumor / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*
chemical_list: D035683:MicroRNAs