title: Symptomatic infection and detection of vaccine and vaccine-reassortant rotavirus strains in 5 children: a case series.
abstract: Vaccine or vaccine-reassortant rotavirus strains were detected in fecal specimens from 5 of 106 (4.7%) immunocompetent children who required treatment for rotavirus gastroenteritis at a large pediatric hospital in Texas in 2009-2010. Four strains were related to pentavalent rotavirus vaccine, whereas one was related to monovalent rotavirus vaccine. The contribution of these strains to each patient's illness was unclear given that 2 patients had prominent respiratory symptoms and 2 were concurrently infected with another pathogen (group F adenovirus and norovirus). Continued monitoring is necessary to assess the role of vaccine strains and vaccine-reassortant strains in pediatric rotavirus infections.
authors.affiliation: Center for Vaccine Awareness and Research, Texas Children’s Hospital, TX, USA. jboom@bcm.edu
authors.forename: Julie A
authors.initials: JA
authors.lastname: Boom
authors.forename: Leila C
authors.initials: LC
authors.lastname: Sahni
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Payne
authors.forename: Rashi
authors.initials: R
authors.lastname: Gautam
authors.forename: Freda
authors.initials: F
authors.lastname: Lyde
authors.forename: Slavica
authors.initials: S
authors.lastname: Mijatovic-Rustempasic
authors.forename: Michael D
authors.initials: MD
authors.lastname: Bowen
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Rench
authors.forename: Jon R
authors.initials: JR
authors.lastname: Gentsch
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Baker
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification*; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000175:diagnosis* / Q000821:virology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D013781:Texas
chemical_list: D022243:Rotavirus Vaccines