title: Structure elucidation and inhibitory effects on NO production of clerodane diterpenes from Ajuga decumbens.
abstract: Three new clerodane diterpenes (1-3), together with five known analogues (4-8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1-4 and 6-8 showed inhibitory effects.
authors.affiliation: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.
authors.forename: Zhanping
authors.initials: Z
authors.lastname: Sun
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011134:Polysaccharides / Q000009:adverse effects
chemical_list: D045785:Diterpenes, Clerodane; D010936:Plant Extracts; D011134:Polysaccharides; D009569:Nitric Oxide