title: Piperidin-4-one: the potential pharmacophore.
abstract: The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.
authors.affiliation: Babu Banarasi Das Northern India Institute of Technology, BBD City, Faizabad Road, Lucknow, U.P., India.
authors.forename: Shashi Kant
authors.initials: SK
authors.lastname: Sahu
authors.forename: Bidhyut Kumar
authors.initials: BK
authors.lastname: Dubey
authors.forename: Avinash C
authors.initials: AC
authors.lastname: Tripathi
authors.forename: Mary
authors.initials: M
authors.lastname: Koshy
authors.forename: Shailendra K
authors.initials: SK
authors.lastname: Saraf
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019427:HIV Integrase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D012640:Seizures / Q000188:drug therapy; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000927:Anticonvulsants; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D010880:Piperidines; D019427:HIV Integrase