title: The RSV fusion receptor: not what everyone expected it to be.
abstract: This article reviews current knowledge about respiratory syncytial virus (RSV) binding and entry into cells. The recent discovery of Nucleolin as a fusion receptor for RSV opens new avenues for developing interventions, while raising questions concerning RSV pathobiology and tropism. We also discuss characteristics of a good RSV drug target.
authors.affiliation: Dept. of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Mastrangelo
authors.forename: Richard G
authors.initials: RG
authors.lastname: Hegele
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D018357:Respiratory Syncytial Virus Infections / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000378:metabolism / Q000502:physiology*; D014760:Viral Fusion Proteins / Q000378:metabolism; D056189:Viral Tropism; D053585:Virus Attachment; D053586:Virus Internalization; D000097796:Nucleolin
chemical_list: D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D011991:Receptors, Virus; D014760:Viral Fusion Proteins; D000097796:Nucleolin