title: Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells.
abstract: Chronic ingestion of arsenic is associated with an increased risk of vascular disease such as atherosclerosis. Previously, we showed that arsenite inhibits the synthesis of general proteoglycans (PGs), which are key molecules in the progression of atherosclerosis, in vascular endothelial cells. In the present study, we investigated the effect of several metals on arsenite-induced inhibitory effect in endothelial cells. The results indicate that, after 24-hr incubation, the inhibition of PG synthesis caused by sodium arsenite was protected by bismuth nitrate but not zinc sulfate, manganese chloride, nickel chloride or cobalt chloride. The accumulation of arsenic in the cell layer was significantly decreased by bismuth after 12-hr incubation and that of bismuth was also decreased by arsenite. It was therefore suggested that the protective effect of bismuth against the inhibitory effect of arsenite on PG synthesis in vascular endothelial cells may be due, at least in part, to the decrease in cellular arsenic accumulation.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Chika
authors.initials: C
authors.lastname: Yamamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Inagaki
authors.forename: Masahiko
authors.initials: M
authors.lastname: Satoh
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kaji
mesh_terms: D000818:Animals; D018053:Arsenites / Q000493:pharmacokinetics / Q000633:toxicity*; D001729:Bismuth / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology; D011509:Proteoglycans / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*
chemical_list: D018053:Arsenites; D011509:Proteoglycans; C015001:arsenite; D001729:Bismuth