title: Destabilizing giant vesicles with electric fields: an overview of current applications.
abstract: This review presents an overview of the effects of electric fields on giant unilamellar vesicles. The application of electrical fields leads to three basic phenomena: shape changes, membrane breakdown, and uptake of molecules. We describe how some of these observations can be used to measure a variety of physical properties of lipid membranes or to advance our understanding of the phenomena of electropermeabilization. We also present results on how electropermeabilization and other liposome responses to applied fields are affected by lipid composition and by the presence of molecules of therapeutic interest in the surrounding solution.
authors.affiliation: Laboratoire de Physique Théorique, CNRS UMR 5152, Université Paul Sabatier, Toulouse, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Portet
authors.forename: Chloé
authors.initials: C
authors.lastname: Mauroy
authors.forename: Vincent
authors.initials: V
authors.lastname: Démery
authors.forename: Thibault
authors.initials: T
authors.lastname: Houles
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Escoffre
authors.forename: David S
authors.initials: DS
authors.lastname: Dean
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Rols
mesh_terms: D018274:Electroporation; D008561:Membrane Fusion; D008968:Molecular Conformation; D010539:Permeability; D018583:Pliability; D013816:Thermodynamics; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D053835:Unilamellar Liposomes