title: New insights in pharmaceutical analysis.
abstract: The research unit of pharmaceutical analytical chemistry (PAC) has been active in the field of separation sciences for many years. Liquid chromatography (LC) and its latest improvements such as ultra-high performance chromatography (UHPLC) and supercritical fluid chromatography (SFC)  are deeply and thoroughly studied, from a fundamental viewpoint to its various application capabilities. Electro-driven separations such as capillary electrophoresis (CE) are also a major field of interest, especially for macromolecules, and low cost. All these techniques are investigated  with various detection modes including mass spectrometry (MS) for various applications where high sensitivity and selectivity is needed. Extracting the relevant information from the overwhelming amount of data generated by modern analytical platforms has become an important issue for knowledge  discovery in various research fields. The appropriate treatment of such data is therefore of crucial importance to provide valuable information. Numerous works in our research group have demonstrated the usefulness of statistical and mathematical methodologies to improve quality of the results.  Therefore, well-established chemometric approaches (e.g. design of experiments, multivariate data analysis, etc.) are implemented to optimize the analytical process from method development to data analysis.
authors.affiliation: Research Unit of Pharmaceutical Analytical Chemistry, School of Pharmaceutical Sciences, Geneva-Lausanne, University of Geneva, 20 bd d'Yvoy CH-1211 Geneva 4, Switzerland.
authors.forename: Davy
authors.initials: D
authors.lastname: Guillarme
authors.forename: Julie
authors.initials: J
authors.lastname: Schappler
authors.forename: Julien
authors.initials: J
authors.lastname: Boccard
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Veuthey
authors.forename: Serge
authors.initials: S
authors.lastname: Rudaz
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D025924:Chromatography, Supercritical Fluid; D057225:Data Mining; D019075:Electrophoresis, Capillary; D013058:Mass Spectrometry; D055432:Metabolomics; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012015:Reference Standards
chemical_list: D004364:Pharmaceutical Preparations