title: Chukrasones A and B: potential Kv1.2 potassium channel blockers with new skeletons from Chukrasia tabularis.
abstract: Two new limonoids, chukrasone A (1) incorporating a highly rearranged A/B ring system and chukrasone B (2) possessing the first 16,19-dinor limonoid backbone with an extended C3 unit at C-15, were isolated from Chukrasia tabularis. Their structures were characterized on the basis of detailed spectroscopic analysis. Compounds 1 and 2 exhibited potential inhibition of the delayed rectifier (I(K)) K(+) current.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Zhao-Bing
authors.initials: ZB
authors.lastname: Gao
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D051663:Kv1.2 Potassium Channel / Q000037:antagonists & inhibitors*; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D026902:Potassium Channel Blockers / Q000494:pharmacology*
chemical_list: D051663:Kv1.2 Potassium Channel; D036701:Limonins; D026902:Potassium Channel Blockers; C579052:chukrasone A; C579053:chukrasone B