title: Ototoxicity of cisplatin administered to guinea pigs via the round window membrane.
abstract: Animal models of ototoxicity represent an elementary tool in otolaryngologic research. Such models are usually created via the consecutive injection of ototoxic drugs or the co-administration of ethacrynic acid and low-dose ototoxic drugs. Injection via the round window membrane (RWM) is one approach that allows for local drug delivery into the inner ear. In this study, 47 guinea pigs received an injection of varying doses of cisplatin via the RWM, and data concerning the animals' auditory brainstem responses, hair cells, and spiral ganglion neurons were analyzed. Our results indicate the high efficiency and generally small reaction of the subjects, suggesting that the application of cisplatin via the RWM is an effective animal model for ototoxicity research.
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.forename: Zhengnong
authors.initials: Z
authors.lastname: Chen
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000473:pathology* / Q000601:surgery; D007758:Ear, Inner / Q000187:drug effects / Q000473:pathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000473:pathology; D012405:Round Window, Ear / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology
chemical_list: D002945:Cisplatin