title: Intravoxel incoherent motion MR imaging of the kidney: pilot study.
abstract: MR examinations (Achieva 3 T, Philips, Best, The Netherlands) were performed at five different occasions in a healthy volunteer (male 60 years) and in one renal cancer patient (male 78 years) with normal renal function (creatinine 88 μmol/L). Intravoxel incoherent motion (IVIM) coefficients D + D* were measured using respiratory-triggered diffusion-weighted spin-echo echo-planar imaging. Perfusion data of the patient were acquired using a saturation-recovery gradient-echo sequence and with the bolus of Gd-BOPTA (Multihance). D + D* were computed by monoexponential fitting of MR signal intensity attenuation versus b for b = 0, 50, 100, 150 s/mm(2). Perfusion parameters were evaluated with "NordicICE" software. The map of D + D* was compared qualitatively with the perfusion map computed from the Gd scan. D + D* values of the cortex and medulla were in the range 2.3-2.7 and 1.1-1.6 × 10(-3) mm(2)/s, respectively. In conclusion, in this pilot study a good qualitative relation between IVIM variables D + D* and renal perfusion has been found.
authors.affiliation: Department of Radiology, Center for Medical Imaging, Uppsala University Hospital, Uppsala University, Uppsala, 75263, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Eckerbom
authors.affiliation: Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Hansell
authors.affiliation: Department of Radiology, Center for Medical Imaging, Uppsala University Hospital, Uppsala University, Uppsala, 75263, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Bjerner
authors.affiliation: Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Palm
authors.affiliation: Department of Radiology, Center for Medical Imaging, Uppsala University Hospital, Uppsala University, Uppsala, 75263, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Weis
authors.affiliation: Department of Radiology, Center for Medical Imaging, Uppsala University Hospital, Uppsala University, Uppsala, 75263, Sweden. per.liss@radiol.uu.se.
authors.forename: Per
authors.initials: P
authors.lastname: Liss
mesh_terms: D000368:Aged; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005682:Gadolinium; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007668:Kidney / Q000166:cytology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D003287:Contrast Media; D005682:Gadolinium