title: Accelerating effect of soy peptides containing collagen peptides on type I and III collagen levels in rat skin.
abstract: Two weeks of feeding soy peptides containing 2% collagen peptides increased the levels of type I and III tropocollagen and their mRNAs. In contrast, the diet did not increase the mRNA levels of rat hyaluronan synthases, serine palmitoyltransferase (the rate-limiting enzyme of ceramide synthesis), and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (the key enzyme of cholesterol synthesis). These results suggest that feeding of soy peptides with collagen peptides specifically enhanced the tropocollagen level in the skin.
authors.affiliation: Department of Nutritional Sciences, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Hitomi
authors.initials: H
authors.lastname: Itoh
authors.forename: Marie
authors.initials: M
authors.lastname: Aoki
authors.forename: Sachie
authors.initials: S
authors.lastname: Ogawa
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamane
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Baba
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tachibana
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Kohno
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oishi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kobayashi-Hattori
mesh_terms: D000284:Administration, Oral; D000818:Animals; D024042:Collagen Type I / Q000096:biosynthesis*; D024061:Collagen Type III / Q000096:biosynthesis*; D004032:Diet; D015870:Gene Expression / Q000187:drug effects; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D000076002:Hyaluronan Synthases; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D051102:Serine C-Palmitoyltransferase / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D030262:Soybean Proteins / Q000008:administration & dosage*; D014332:Tropocollagen / Q000096:biosynthesis*
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D010455:Peptides; D012333:RNA, Messenger; D030262:Soybean Proteins; D014332:Tropocollagen; D006903:Hydroxymethylglutaryl CoA Reductases; D051102:Serine C-Palmitoyltransferase; D014453:Glucuronosyltransferase; D000076002:Hyaluronan Synthases