title: Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study.
abstract: OBJECTIVE
  To evaluate the association of Insulin-like Growth Factor (IGF) I-related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP).
  
  
  METHODS
  From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 20-59 years were analysed. Serum IGF-I and IGF-binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines.
  
  
  RESULTS
  In fully adjusted models, for serum IGFBP-3 values ≤1200 ng/ml, mean CAL increased significantly for decreasing serum IGFBP-3 levels [B = -0.027 (95% CI, -0.049; -0.005), p = 0.02]. The odds for high tooth loss decreased significantly for high serum IGFBP-3 values [OR = 0.97 (0.95; 0.99), p = 0.02]. Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment.
  
  
  CONCLUSIONS
  Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.
authors.affiliation: Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, Dental school, University Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors.forename: Ali N
authors.initials: AN
authors.lastname: Harb
authors.forename: Birte
authors.initials: B
authors.lastname: Holtfreter
authors.forename: Nele
authors.initials: N
authors.lastname: Friedrich
authors.forename: Henri
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: Matthias
authors.initials: M
authors.lastname: Nauck
authors.forename: Martin
authors.initials: M
authors.lastname: Albers
authors.forename: Peter
authors.initials: P
authors.lastname: Meisel
authors.forename: Reiner
authors.initials: R
authors.lastname: Biffar
authors.forename: Thomas
authors.initials: T
authors.lastname: Kocher
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004245:DMF Index; D005858:Germany / Q000453:epidemiology; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood* / Q000453:epidemiology; D010518:Periodontitis / Q000097:blood* / Q000453:epidemiology; D016388:Tooth Loss / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I