title: Synthesis and characterization of new thiazolidinones containing coumarin moieties and their antibacterial and antioxidant activities.
abstract: New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds were screened for antibacterial activity. Most of them are more active against E. coli S. aureus and B. subtilis than standard references.
authors.affiliation: College of Science and Arts at Ar-Rass, Qassim University, P.O. Box 53, Saudi Arabia. naceur.hamdi@isste.rnu.tn
authors.forename: Naceur
authors.initials: N
authors.lastname: Hamdi
authors.forename: Abdullah Sulaiman
authors.initials: AS
authors.lastname: Al-Ayed
authors.forename: Ridha
authors.initials: R
authors.lastname: Ben Said
authors.forename: Alary
authors.initials: A
authors.lastname: Fabienne
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D003198:Computer Simulation; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010851:Picrates / Q000737:chemistry; D011514:Proteus vulgaris / Q000187:drug effects; D011789:Quantum Theory; D013055:Spectrophotometry, Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013451:Sulfonic Acids / Q000737:chemistry; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D003374:Coumarins; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; D013451:Sulfonic Acids; D045162:Thiazolidinediones; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl