title: Frequency of recurrence after surgical treatment of cervical intraepithelial neoplasia grade 1-3.
abstract: OBJECTIVE
  The objective was to demonstrate the frequency of invasive cervical cancer or recurrent CIN in patients treated by a previous diagnosis of CIN 1-3.
  
  
  METHODS
  We analyzed 1,397 records colpocytologic and medical records. Recurrence of CIN or invasive neoplasia of the cervix after treatment of CIN was assessed. The chi-square test was used for statistical analysis (significance level set at less than 0.05).
  
  
  RESULTS
  We obtained 696 CIN 1, 244 CIN 2, 451 CIN 3, and six squamous carcinoma. Regarding patients who relapsed, there were 6/690 (0.9%) patients had an initial diagnosis of CIN 1, 8/236 (3.4%) CIN 2 and 21/430 (4.9%) CIN 3 (p < 0.0001). Comparing the frequency of relapse among each group, we found: CIN 1 vs CIN 2: p = 0.0073; CIN 1 vs CIN 3: p < 0.0001; CIN 2 vs CIN 3: p = 0.38.
  
  
  CONCLUSIONS
  Although the number of relapses when comparing CIN 2 and CIN 3 were not significant, the data suggest that CIN 2 has lower recurrence rates, so these patients require more conservative treatment if a desire of future pregnancy is expressed.
authors.affiliation: Oncological Research Institute (IPON)/Discipline of Gynecology and Obstetrics, Federal University of the Tridngulo Mineiro, Uberaba, MG, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Nomelini
authors.forename: T S F
authors.initials: TS
authors.lastname: Kamikabeya
authors.forename: S J
authors.initials: SJ
authors.lastname: Adad
authors.forename: E F C
authors.initials: EF
authors.lastname: Murta
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery*