title: An unusual association between growth hormone deficiency and a middle cranial fossa arachnoid cyst.
abstract: Middle cranial fossa arachnoid cysts (MFACs) are frequently asymptomatic. Here, we report the case of a 10-year-old boy with growth hormone deficiency (GHD) and an MFAC. His linear growth had followed the -2.5 SD line. On physical examination, his height was 120.8 cm (-2.6 SD), and the level of insulin-like growth factor 1 was low (87 ng/mL). GH provocative tests revealed GHD and brain magnetic resonance imaging (MRI) revealed an MFAC. We started treatment with GH replacement therapy (0.175 mg/kg/week). At the age of 12 years and 9 months, there were no interval changes in the features of the MFAC on the brain MRI. As his height was 145.5 cm (-1.7 SD) at the age of 13 years and 4 months, the therapy seems to be successful without sequelae. GH replacement therapy is suggested to be safe and effective to treat patients with GHD associated with arachnoid cysts.
authors.affiliation: Department of Pediatrics, Disaster Medical Center, 3256 Midori-cho, Tachikawa, Tokyo 190-0014, Japan. koikey@tdmc.hosp.go.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koike
authors.forename: Nao
authors.initials: N
authors.lastname: Aoki
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D016080:Arachnoid Cysts / Q000150:complications* / Q000473:pathology*; D002648:Child; D035301:Cranial Fossa, Middle / Q000473:pathology*; D004393:Dwarfism, Pituitary / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D020249:Hormone Replacement Therapy / Q000379:methods; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008297:Male
chemical_list: D019382:Human Growth Hormone