title: A case of paravertebral mediastinal chordoma without bone destruction.
abstract: We report a unique case of mediastinal paravertebral chordoma without bone destruction in a 47-year-old Japanese woman. She was admitted to hospital after a tumor was incidentally detected on a chest radiograph. The tumor was located in the paravertebral region of the mediastinum and did not show any destruction of the thoracic vertebra radiologically. The tumor was clinically diagnosed as a benign neurogenic tumor and the tumor was easily removed surgically. Microscopically, the tumor mainly consisted of tumor cells with extensively vacuolated cytoplasm, arranged in cord- and nest-like fashion against a myxoid matrix background. Immunohistochemically, the tumor cells showed diffuse positivity for pancytokeratin (AE1/AE3) and vimentin. The tumor cell nuclei were positive for brachyury, which is a key transcription factor of notochordal development. These results confirmed the tumor to be an extraosseous chordoma in the paravertebral mediastinal region, which is an extremely rare location for a chordoma.
authors.affiliation: Department of Anatomic Pathology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. jun-ma@tokyo-med.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Matsubayashi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sato
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nomura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kakihana
authors.forename: Osamu
authors.initials: O
authors.lastname: Uchida
authors.forename: Hisashi
authors.initials: H
authors.lastname: Saji
authors.forename: Jinho
authors.initials: J
authors.lastname: Park
authors.forename: Souichi
authors.initials: S
authors.lastname: Akata
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ikeda
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nagao
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ishida
mesh_terms: D002817:Chordoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008479:Mediastinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D010014:Osteolysis / Q000175:diagnosis / Q000209:etiology; D013125:Spinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome