title: Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.
abstract: OBJECTIVE
  To investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.
  
  
  METHODS
  The study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including 38 patients with intermediate uveitis (IU), 38 patients with Vogt-Koyanagi-Harada disease (VKH), and 19 patients with Behçet's disease and 308 healthy controls. The genotypes of CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were determined using TaqMan single nucleotide polymorphism genotyping assays.
  
  
  RESULTS
  The frequency of carriers of G allele for CFH-rs800292 was significantly higher in patients with non-infectious intermediate and posterior uveitis than in controls (GG/AG versus AA; p=0.02). No significant association was found between uveitis and both KIAA1109-rs4505848 and IL27-rs4788084. In stratified analysis by gender, the frequency of carriers with G allele for KIAA1109-rs4505848 was significantly higher in male uveitis patients than in male controls (GG/AG versus AA; p=0.034). There was no significant difference in allelic and genotypic frequencies for CFH-rs800292 and IL27-rs4788084 in either male or female groups. In addition, higher frequency of KIAA1109-rs4505848 G allele was found in Behçet's disease patients compared with controls and IU patients (p=0.01 and p=0.003, respectively).
  
  
  CONCLUSIONS
  Our results demonstrated that CFH-rs800292 and KIAA1109-rs4505848 are associated with non-infectious intermediate and posterior uveitis. Moreover, gender susceptibility for uveitis might be involved in the KIAA1109 gene and the KIAA1109-rs4505848 polymorphism might be associated with the development of Behçet's disease.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Yang
authors.forename: Timothy Y Y
authors.initials: TY
authors.lastname: Lai
authors.forename: Pancy O S
authors.initials: PO
authors.lastname: Tam
authors.forename: Sylvia W Y
authors.initials: SW
authors.lastname: Chiang
authors.forename: Carmen K M
authors.initials: CK
authors.lastname: Chan
authors.forename: Fiona O J
authors.initials: FO
authors.lastname: Luk
authors.forename: Tsz-Kin
authors.initials: TK
authors.lastname: Ng
authors.forename: Chi-Pui
authors.initials: CP
authors.lastname: Pang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D017242:Complement Factor H / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014606:Uveitis, Anterior / Q000235:genetics*; D015866:Uveitis, Posterior / Q000235:genetics*; D014607:Uveomeningoencephalitic Syndrome / Q000235:genetics*
chemical_list: D007378:Interleukins; C464565:MYDGF protein, human; D017242:Complement Factor H