title: Noncovalent organocatalytic synthesis of enantioenriched terminal aziridines with a quaternary stereogenic center.
abstract: A high-yielding and enantioselective access to novel N-Boc terminal aziridines, bearing a quaternary stereogenic center, has been developed via an aza-Michael initiated ring-closure (aza-MIRC) reaction of α-acyl acrylates with an N-tosyloxy tert-butyl carbamate catalyzed by a chiral amino thiourea. The feasibility of the aziridine regioselective ring-opening to valuable α,α-disubstituted α-amino acid esters has been demonstrated.
authors.affiliation: Dipartimento di Chimica e Biologia, Università di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: De Fusco
authors.forename: Tiziana
authors.initials: T
authors.lastname: Fuoco
authors.forename: Gianluca
authors.initials: G
authors.lastname: Croce
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lattanzi