title: Canonical correlation analysis in the study of cerebral and peripheral haemodynamics interrelations with systemic variables in neonates supported on ECMO.
abstract: Neonates supported on extracorporeal membrane oxygenation (ECMO) are at high risk of brain injury due to haemodynamic instability. In order to monitor cerebral and peripheral (muscle) haemodynamic and oxygenation changes in this population we used a dual-channel near-infrared spectroscopy (NIRS) system. In addition, to assess interrelations between NIRS and systemic variables, collected simultaneously, canonical correlation analysis (CCA) was employed. CCA can quantify the relationship between a set of variables and assess levels of dependency. In four out of five patients, systemic variables were found to be less inter-related with cerebral rather than peripheral NIRS measurements. Moreover, during ECMO flow manipulations, we found that the interrelation between the systemic and the NIRS cerebral/peripheral variables changed. The CCA method presented here can be used to assess differences between NIRS cerebral and NIRS peripheral responses due to systemic variations which may be indicative of physiological differences in the mechanisms that regulate oxygenation and/or haemodynamics of the brain and the muscle.
authors.affiliation: ESAT/SCD, Department of Electrical Engineering & IBBT Future Health Department, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Alexander
authors.initials: A
authors.lastname: Caicedo
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, 18 Dickensons Lane, London, WC1E 6BT, UK.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Papademetriou
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, 18 Dickensons Lane, London, WC1E 6BT, UK.
authors.forename: Clare E
authors.initials: CE
authors.lastname: Elwell
authors.affiliation: Great Ormond Street Hospital for Children, London, UK.
authors.forename: Aparna
authors.initials: A
authors.lastname: Hoskote
authors.affiliation: Great Ormond Street Hospital for Children, London, UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Elliott
authors.affiliation: ESAT/SCD, Department of Electrical Engineering & IBBT Future Health Department, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, 18 Dickensons Lane, London, WC1E 6BT, UK. iliastac@medphys.ucl.ac.uk.
authors.forename: Ilias
authors.initials: I
authors.lastname: Tachtsidis
mesh_terms: D001921:Brain / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002675:Child, Preschool; D005112:Extracorporeal Circulation; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015233:Models, Statistical; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000378:metabolism*; D012131:Respiratory Insufficiency / Q000517:prevention & control*; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen