title: Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy.
abstract: OBJECTIVE
  To evaluate the prognostic risk factors for failure of trabeculectomy with mitomycin C (MMC) in vitrectomized eyes.
  
  
  METHODS
  Retrospective cohort study. We reviewed the medical records of 116 patients (116 eyes) treated at Kumamoto University Hospital. The primary endpoints were persistent intraocular pressure of >21 mmHg, deterioration of visual acuity to no light perception, or additional glaucoma procedures. Multivariable analysis was performed with the Cox proportional hazards model.
  
  
  RESULTS
  The mean follow-up period was 36.5 months (range, 0.5-134.1 months). The probability of success 1 year after trabeculectomy was 55.1 %, 2 years after was 45.3 %, and 3 years after was 43.1 %. The multivariable model showed that higher preoperative intraocular pressure (IOP) [relative risk (RR), 1.05/mmHg; P = 0.0077] and neovascular glaucoma (NVG) (RR, 1.88; P = 0.049) were prognostic factors for surgical failure.
  
  
  CONCLUSIONS
  The prognostic factors for surgical failure of trabeculectomy with MMC in vitrectomized eyes are a higher preoperative IOP and NVG.
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan. noel@da2.so-net.ne.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Inoue
authors.forename: Masaru
authors.initials: M
authors.lastname: Inatani
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takihara
authors.forename: Nanako
authors.initials: N
authors.lastname: Awai-Kasaoka
authors.forename: Minako
authors.initials: M
authors.lastname: Ogata-Iwao
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000477:Alkylating Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011379:Prognosis; D012164:Retinal Diseases / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D014065:Tonometry, Ocular; D014130:Trabeculectomy; D017211:Treatment Failure; D014821:Vitrectomy; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin