title: Preparation of anionic polyurethane nanoparticles and blood compatible behaviors.
abstract: The anionic polyurethane nanoparticles (APU-NPs) were obtained by an emulsion polymerization method. It was found that the average size of the prepared APU-NPs is about 84 nm, and the APU-NPs have zeta-potential of -38.9 mV. The bulk characterization of synthesized APU-NPs was investigated by FTIR. The blood compatibility of APU-NPs was characterized by in vitro for coagulation tests, complement activation, platelet activation, cytotoxicity experiments, and hemolysis assay. The results showed that the APU-NPs synthesized in this paper are blood compatible with low level of cell cytotoxicity, and the results were significant for their potential use in vivo.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
authors.forename: Qinshu
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Huang
authors.forename: Jianchun
authors.initials: J
authors.lastname: Bao
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000838:Anions / Q000737:chemistry; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D003167:Complement Activation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D015539:Platelet Activation / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry*
chemical_list: D000838:Anions; D000925:Anticoagulants; D001672:Biocompatible Materials; D004337:Drug Carriers; D004655:Emulsions; D011140:Polyurethanes