title: Association of GATA4 sequence variation with alcohol dependence.
abstract: To further explore reports of association of alcohol dependence and response to acamprosate treatment with the GATA4 rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other GATA4 SNPs in 816 alcohol-dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between GATA4 and alcohol dependence at the gene level (P = 0.009) but no association with rs13273672. Further studies are needed to identify potential causal GATA4 variation(s) and the functional mechanism(s) contributing to this association.
authors.affiliation: Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Karpyak
authors.forename: Stacey J
authors.initials: SJ
authors.lastname: Winham
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Biernacka
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: Kriste A
authors.initials: KA
authors.lastname: Lewis
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Geske
authors.forename: Colin L
authors.initials: CL
authors.lastname: Colby
authors.forename: Osama A
authors.initials: OA
authors.lastname: Abulseoud
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Hall-Flavin
authors.forename: Larissa L
authors.initials: LL
authors.lastname: Loukianova
authors.forename: Terry D
authors.initials: TD
authors.lastname: Schneekloth
authors.forename: Mark A
authors.initials: MA
authors.lastname: Frye
authors.forename: John A
authors.initials: JA
authors.lastname: Heit
authors.forename: David A
authors.initials: DA
authors.lastname: Mrazek
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D050991:GATA4 Transcription Factor / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D025341:Principal Component Analysis
chemical_list: D050991:GATA4 Transcription Factor; C484170:GATA4 protein, human