title: Symptomatic venous thromboembolism is a disease related to infection and immune dysfunction.
abstract: The characteristics of human genomics and cellular immune function between clinically symptomatic venous thromboembolism (VTE) and controls were systematically compared to explore the immunologic pathogenesis of VTE. Microarray assay showed the mRNA expressions of genes related to non-specific cellarer immune and cytokines were significantly down-regulated. Abnormal expressions of CD3+, CD4+, CD8+, NK marker CD16+56+, CD19 and aberrant CD4+/CD8+ ratio were detected in 54 among 56 patients. In PE patients, microarray assay revealed the imbalance in the expressions of genes related to the immune system. The expressions of genes related to non-specific immune cells and cytokines were markedly up-regulated and those associated with cellular immune were dramatically down-regulated. In VTE patients, cytological examination indicated the functions of NK cells were significantly compromised, and the antigen recognition and killing function of T cells markedly decreased. The consistence between genomic and cytological examination suggests the symptomatic VTE is closely associated with the infection and immune dysfunction.
authors.affiliation: Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
authors.forename: Qianglin
authors.initials: Q
authors.lastname: Duan
authors.forename: Zhu
authors.initials: Z
authors.lastname: Gong
authors.forename: Haoming
authors.initials: H
authors.lastname: Song
authors.forename: Lemin
authors.initials: L
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
authors.forename: Yanli
authors.initials: Y
authors.lastname: Song
mesh_terms: D018941:Antigens, CD19 / Q000235:genetics; D017252:CD3 Complex / Q000235:genetics; D016516:CD4-CD8 Ratio; D019002:CD56 Antigen / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D017452:Receptors, IgG / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D054556:Venous Thromboembolism / Q000235:genetics* / Q000276:immunology*
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex; D019002:CD56 Antigen; D017452:Receptors, IgG