title: Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats.
abstract: The aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO(2)), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO(2) in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.
authors.affiliation: Functional Food Research Department, Food Science & Technology Institute, Morinaga Milk Industry Co. Ltd., Zama, Kanagawa, Japan. e_misawa@morinagamilk.co.jp
authors.forename: Eriko
authors.initials: E
authors.lastname: Misawa
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Kouji
authors.initials: K
authors.lastname: Nomaguchi
authors.forename: Muneo
authors.initials: M
authors.lastname: Yamada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Toida
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwatsuki
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D059305:Diet, High-Fat; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D008055:Lipids