title: Immunogenicity of a 23-valent pneumococcal polysaccharide vaccine among Mexican children.
abstract: OBJECTIVE
  Streptococcus pneumoniae infection continues to be a major source of morbidity and mortality in children in Mexico. The aim of this study was to evaluate the immune response to six serotypes in children <5 years of age after immunization with a 23-valent pneumococcal polysaccharide vaccine.
  
  
  METHODS
  A prospective study was conducted among children aged from 18 months to 4 years. Pre- and postvaccination titers for the serotypes selected in this project demonstrate a substantial response among all age groups.
  
  
  RESULTS
  We identified mild adverse events in 62% of the participants in this study. No serious adverse events were reported during the study.
  
  
  CONCLUSIONS
  Pneumococcal polysaccharide vaccine produced adequate immunogenicity in all age groups evaluated.
authors.affiliation: Immunodeficiency Research Unit, National Institute of Pediatrics, Mexico City, Mexico.
authors.forename: Sara Elva
authors.initials: SE
authors.lastname: Espinosa-Padilla
authors.forename: Chiharu
authors.initials: C
authors.lastname: Murata
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada-Parra
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Santos-Argumedo
authors.forename: Cesar
authors.initials: C
authors.lastname: Mascareñas
authors.forename: Carlos
authors.initials: C
authors.lastname: Franco-Paredes
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Espinosa-Rosales
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial