title: Metabolomics in food analysis: application to the control of forbidden substances.
abstract: Metabolomics is a science of interest in food analysis to describe and predict properties of food products and processes. It includes the development of analytical methods with the ultimate goal being the identification of so-called 'quality markers', (i.e. sets of metabolites that correlate with, for example, quality, safety, taste, or fragrance of foodstuffs). In turn, these metabolites are influenced by factors as genetic differences of the raw food ingredients (such as animal breed or crop species differences), growth conditions (such as climate, irrigation strategy, or feeding) or production conditions (such as temperature, acidity, or pressure). In cases where the routine-based measurement of a food property faces some limitations such as the lack of knowledge regarding the target compounds to monitor, monitoring based on a limited set of crucial biomarkers is a good alternative, which is of great interest for food safety purposes regarding growth promoting practices. Such an approach may be more efficient than using a classic approach based on a limited set of known metabolites of anabolic compounds. In this context, screening strategies allowing detection of the physiological response resulting from anabolic compound administration are promising approaches to detect their misuse. The global metabolomics workflow implemented for such studies is presented and illustrated through various examples of biological matrices profiling (tissue, blood, urine) and for different classes of anabolic compounds (steroids, β-agonists and somatotropin).
authors.affiliation: LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, France.
authors.forename: Gaud
authors.initials: G
authors.lastname: Dervilly-Pinel
authors.forename: Frédérique
authors.initials: F
authors.lastname: Courant
authors.forename: Sylvain
authors.initials: S
authors.lastname: Chéreau
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Royer
authors.forename: Fanny
authors.initials: F
authors.lastname: Boyard-Kieken
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D045930:Anabolic Agents / Q000032:analysis* / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000818:Animals; D005504:Food Analysis / Q000379:methods*; D013006:Growth Hormone / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000652:urine; D055432:Metabolomics / Q000379:methods*; D013256:Steroids / Q000032:analysis* / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015813:Substance Abuse Detection / Q000379:methods / Q000662:veterinary*
chemical_list: D045930:Anabolic Agents; D013256:Steroids; D013006:Growth Hormone