title: Pathological and aetiological studies in sheep exhibiting extrathoracic metastasis of ovine pulmonary adenocarcinoma (Jaagsiekte).
abstract: Seven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extrathoracic metastases were found in the liver, kidneys, skeletal muscle, digestive tract, spleen, skin and adrenal glands. Intrathoracic metastases involved the chest wall, regional lymph nodes, diaphragm and heart. Immunohistochemistry and polymerase chain reaction allowed detection of JSRV-related protein and nucleic acid, respectively, in the extrathoracic tumours of all cases. It is concluded that extrathoracic metastases constitute a pathological event of ovine pulmonary adenocarcinoma and confirm the malignant character of this virus-induced neoplasia.
authors.affiliation: Departamento de Sanidad Animal, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio, Vizcaya, Spain. eminguijon@neiker.net
authors.forename: E
authors.initials: E
authors.lastname: Minguijón
authors.forename: L
authors.initials: L
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: De las Heras
authors.forename: N
authors.initials: N
authors.lastname: Gómez
authors.forename: M
authors.initials: M
authors.lastname: García-Goti
authors.forename: R A
authors.initials: RA
authors.lastname: Juste
authors.forename: B
authors.initials: B
authors.lastname: Moreno
mesh_terms: D000818:Animals; D005260:Female; D022141:Jaagsiekte sheep retrovirus / Q000302:isolation & purification / Q000472:pathogenicity*; D007668:Kidney / Q000473:pathology / Q000821:virology; D007680:Kidney Neoplasms / Q000556:secondary / Q000662:veterinary* / Q000821:virology; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary* / Q000821:virology; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D019042:Muscle Neoplasms / Q000556:secondary / Q000662:veterinary / Q000821:virology; D018482:Muscle, Skeletal / Q000473:pathology / Q000821:virology; D011648:Pulmonary Adenomatosis, Ovine / Q000473:pathology* / Q000821:virology*; D012189:Retrospective Studies; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology* / Q000821:virology*; D013154:Spleen / Q000473:pathology / Q000821:virology; D013160:Splenic Neoplasms / Q000556:secondary / Q000662:veterinary / Q000821:virology