title: Synthesis and comparison of 4-[18F]F-ADAM, 2-[18F]F-ADAM, N-Desmethyl-4-[18F]F-ADAM and [18F]F-AFM as serotonin transporter imaging agents.
abstract: 4-[(18)F]F-ADAM (1a), 2-[(18)F]F-ADAM (2a), N-Desmethyl-4-[(18)F]F-ADAM (3a) and [(18)F]F-AFM (4a ) were synthesized in 1.7, 3.9, 2.9 and 0.6% yield (EOS), respectively, in a synthesis time of ~120 min from EOB. PET studies in rats showed that the maximum specific uptake ratios of 1a, 2a, 3a and 4a in midbrain were 3.86, 0.73, 0.35 and 2.23, respectively. Thus, in terms of radiochemical yield, specific binding and in vivo stability, 4-[(18)F]F-ADAM may be the most appropriate SERT imaging agent for human studies.
authors.affiliation: PET Center, Department of Nuclear Medicine, Tri-Service General Hospital, Neihu 114, Taipei, Taiwan.
authors.forename: Ya-Yao
authors.initials: YY
authors.lastname: Huang
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Huang
authors.forename: Kuo-Hsing
authors.initials: KH
authors.lastname: Ma
authors.forename: Ta-Kai
authors.initials: TK
authors.lastname: Chou
authors.forename: Yu-Yeh
authors.initials: YY
authors.lastname: Kuo
authors.forename: Cheng-Yi
authors.initials: CY
authors.lastname: Cheng
authors.forename: Chyng-Yann
authors.initials: CY
authors.lastname: Shiue
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D005462:Fluorine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins