title: Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.
abstract: A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: D'Errico
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Jussara
authors.initials: J
authors.lastname: Amato
authors.forename: Nicola
authors.initials: N
authors.lastname: Borbone
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cerullo
authors.forename: Akseli
authors.initials: A
authors.lastname: Hemminki
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Piccialli
authors.forename: Sabrina
authors.initials: S
authors.lastname: Zaccaria
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D061986:MCF-7 Cells; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D011741:Pyrimidine Nucleosides