title: Induced pluripotent stem cells in research and therapy.
abstract: Induced pluripotent stem cells (iPSC) are derived from human somatic cells through ectopic expression of transcription factors. This landmark discovery has been considered as a major development towards patient-specific iPSC for various biomedical applications. Unlimited self renewal capacity, pluripotency and ease of accessibility to donor tissues contribute to the versatility of iPSC. The therapeutic potential of iPSC in regenerative medicine, cell-based therapy, disease modelling and drug discovery is indeed very promising. Continuous progress in iPSC technology provides clearer understanding of disease pathogenesis and ultimately new optimism in developing treatment or cure for human diseases.
authors.affiliation: Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: Hoon-Koon
authors.initials: HK
authors.lastname: Teoh
authors.forename: Soon-Keng
authors.initials: SK
authors.lastname: Cheong
mesh_terms: D000755:Anemia, Sickle Cell / Q000235:genetics / Q000628:therapy; D000818:Animals; D002454:Cell Differentiation; D017690:Cell Transplantation; D055808:Drug Discovery / Q000379:methods; D005199:Fanconi Anemia / Q000235:genetics / Q000628:therapy; D015316:Genetic Therapy; D006467:Hemophilia A / Q000235:genetics / Q000628:therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation; D051379:Mice; D057285:Precision Medicine / Q000379:methods*; D044968:Regenerative Medicine / Q000379:methods*; D019896:alpha 1-Antitrypsin Deficiency / Q000235:genetics / Q000628:therapy