title: Effect of graded doses of Caesalpinia bonducella seed extract on ovary and uterus in albino rats.
abstract: Histological changes observed under light microscope illustrate follicular degeneration in ovary, vacuolation and mild disorganization of uterus on treatment with graded doses of alcohol seed extract of Caesalpinia bonducella. There was a significant decrease (p≤0.05) in duration of estrous cycle and mean ovarian weight. However, there were no uniform variations in mean uterine weight, serum estradiol and progesterone level. The results suggest that alcohol seed extract of C. bonducella has antiestrogenic property, possibly acting via inhibition of estrogen secretion.
authors.affiliation: Karnatak University, Karnataka, India.
authors.forename: Kanchan R
authors.initials: KR
authors.lastname: Salunke
authors.forename: R Nazeer
authors.initials: RN
authors.lastname: Ahmed
authors.forename: Shambanagouda R
authors.initials: SR
authors.lastname: Marigoudar
mesh_terms: D000818:Animals; D029911:Caesalpinia / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D020847:Estrogen Receptor Modulators / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D030762:Estrous Cycle / Q000097:blood / Q000187:drug effects; D005260:Female; D009929:Organ Size; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D020847:Estrogen Receptor Modulators; D010936:Plant Extracts; D011374:Progesterone; D004958:Estradiol