title: [Hypoprothrombinemia--lupus anticoagulant syndrome].
abstract: Diagnosis criteria, pathogenic mechanisms, incidence and prevalence of the Antiphospholipid Syndrome are focused in a brief review. Hypoprothrombinemia (HPT) may be hereditary or acquired; the first is rare and with recessive autossomic transmission. We report the case of a 66-year-old white woman with Systemic Lupus Erythematosus (SLE), autoimmune haemolytic anaemia, periostitis, haematomas, bleeding leg ulcer and rectal haemorrhages; she had decreased levels of the prothrombin. Haemorrhagic episodes were related with the anti-prothrombin specificity of Lupus Anticoagulant (LA) detected. The SLE/LA/HPT association is less frequent than the correlated to SLE/LA/anti- ß2Glycoprotein I antibodies and was first reported in 1960 by Rapaport et al, in an 11-year- -old girl with severe haemorrhagic manifestations.
authors.affiliation: Serviço de Imuno-Hemoterapia, Hospital de Curry Cabral, Lisbon, Portugal.
authors.forename: Maria Manuel
authors.initials: MM
authors.lastname: Campos
authors.forename: Isabel
authors.initials: I
authors.lastname: Reis Santos
mesh_terms: D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006406:Hematoma / Q000209:etiology; D006801:Humans; D007020:Hypoprothrombinemias / Q000209:etiology*; D007871:Leg Ulcer / Q000150:complications; D016682:Lupus Coagulation Inhibitor / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D010522:Periostitis / Q000209:etiology; D013577:Syndrome
chemical_list: D016682:Lupus Coagulation Inhibitor