title: Nonsebaceous lymphadenoma of salivary gland: report of a case with immunohistochemistry and review of the literature.
abstract: OBJECTIVE
  Nonsebaceous lymphadenomas are rare benign neoplasms. We emphasize the role of immunohistochemistry and attempt to elucidate the pathogenesis by investigating the distribution of 2 transcription factors, MYC and BLIMP1.
  
  
  METHODS
  A 70-year-old man was evaluated for a 3-cm left parotid mass. Ultrasound-guided fine-needle aspiration biopsy findings were suggestive of a diagnosis of pleomorphic adenoma. A left superficial parotidectomy was performed, and based on histopathology a diagnosis of lymphadenoma, nonsebaceous type, was rendered.
  
  
  RESULTS
  The tumor was positive for AE1/3, CKA, BclII, P63, CD79a, CD3, and MYC; focally positive for CK7 and epithelial membrane antigen; and negative for CD10, calponin, CD117, and BLIMP1.
  
  
  CONCLUSIONS
  The rarity of nonsebaceous lymphadenoma and its superficial resemblance to commoner salivary gland tumors may present a diagnostic challenge for pathologists. The expression of MYC in the ductal component and the differentiation-related expression of PRDM1 in the superficial keratinizing layers point to a potential role for these 2 transcription factors in the pathogenesis of this neoplasm.
authors.affiliation: Department of Medical Science, Dentistry, and Biophysics, University of Genoa, Genoa, Italy. f.angiero@teos.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Angiero
authors.forename: Angelita
authors.initials: A
authors.lastname: Ferri
authors.forename: Gabriella Maria
authors.initials: GM
authors.lastname: Valente
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cattoretti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis; D000235:Adenolymphoma / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000473:pathology; D000368:Aged; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053556:Keratin-1 / Q000032:analysis; D053558:Keratin-3 / Q000032:analysis; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D010307:Parotid Neoplasms / Q000473:pathology*; D000074462:Positive Regulatory Domain I-Binding Factor 1; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis; D012097:Repressor Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D016335:Zinc Fingers
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C081876:CKAP4 protein, human; D053556:Keratin-1; D053558:Keratin-3; D008565:Membrane Proteins; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; D009418:S100 Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1