title: Cytokine-secreting activity of blood eosinophils in pulmonary tuberculosis.
abstract: Modern immunological studies showed that eosinophilic granulocytes producing the key mediators of cellular and humoral immune response contribute to the common cytokine imbalance developing in tuberculous infection. A significant increase in BCG-induced secretion of IL-2, IL-5, and TNF-α by eosinophils in patients with pulmonary tuberculosis indicated high reserve reactivity of eosinophilic cells realizing their functional potential in regulation of the specific resistance reactions of the microorganism under conditions of M. tuberculosis infection.
authors.affiliation: Department of Pathophysiology, Siberian State Medical University, Federal Agency for Health and Social Development, Tomsk, Russia. kolobovnikova.julia@mail.ru
authors.forename: U V
authors.initials: UV
authors.lastname: Kolobovnikova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitsky
authors.forename: O V
authors.initials: OV
authors.lastname: Voronkova
authors.forename: I O
authors.initials: IO
authors.lastname: Naslednikova
authors.forename: K O
authors.initials: KO
authors.lastname: Mikheeva
authors.forename: M V
authors.initials: MV
authors.lastname: Ignatov
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D015848:Interleukin-5 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha