title: Long-term effects of injection laryngoplasty with a temporary agent on voice quality and vocal fold position.
abstract: OBJECTIVE
  Patients with unilateral vocal fold paralysis (UVFP) treated with temporary injection laryngoplasty (IL) have a decreased rate of permanent medialization laryngoplasty (ML) compared to UVFP patients initially treated by observation. The aim of this study was to determine whether the lower rate of ML corresponded with improved quantifiable measures.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Examinations at presentation and follow-up of 14 IL patients and 24 observation patients were analyzed for laryngoscopic features and Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) scores.
  
  
  RESULTS
  The groups were similar at presentation. At follow-up, the IL group showed significant improvement in 11/18 laryngoscopic criteria and 7/12 CAPE-V parameters compared to the observation group (P < .05). The observation group underwent ML more frequently than the IL group (75% vs. 29%, P = .008).
  
  
  CONCLUSIONS
  The lower rate of permanent ML in patients undergoing temporary IL corresponds with improvements in CAPE-V scores and laryngoscopic features. Improvements persisted beyond the accepted time frame for temporary graft resorption.
authors.affiliation: Voice and Swallowing Center, Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California 94115, USA.
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Prendes
authors.forename: Katherine C
authors.initials: KC
authors.lastname: Yung
authors.forename: Ilya
authors.initials: I
authors.lastname: Likhterov
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Schneider
authors.forename: Soha A
authors.initials: SA
authors.lastname: Al-Jurf
authors.forename: Mark S
authors.initials: MS
authors.lastname: Courey
mesh_terms: D000368:Aged; D003094:Collagen / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D007267:Injections; D058753:Laryngoplasty / Q000706:statistics & numerical data*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D061226:Recurrent Laryngeal Nerve Injuries / Q000150:complications; D012189:Retrospective Studies; D013995:Time; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000209:etiology / Q000601:surgery*; D014827:Vocal Cords / Q000293:injuries / Q000473:pathology* / Q000601:surgery*; D014833:Voice Quality
chemical_list: C471832:Cymetra; D006820:Hyaluronic Acid; D003094:Collagen; C445361:Restylane