title: Chimerism in women with end stage renal diseases: Who's who?
abstract: Many sources of foreign or semi foreign cells, known as microchimerism (Mc), can be found in healthy individuals. We have recently shown in women with end stage renal disease (ESRD) that Mc frequencies and levels are exacerbated prior to kidney transplantation. Is Mc arising from pregnancy a protective factor for renal diseases explaining lower incidence in women? Is Mc helpful in slowing down disease progression? However, natural Mc is not the only actor as post blood transfusion Mc is also found at high levels in women with ESRD. The difficulty is therefore to distinguish the different types of Mc and this is made even more complicated when the recipient receives a potentially chimeric organ. What part does each source of chimerism play in disease and transplant fate, and can one decipher each role knowing that one chimerism may hide another?
authors.affiliation: UMC Transplantation Rénale, Hôpital Pasteur, Centre Hospitalo-Universitaire de Nice, Nice, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Albano
authors.forename: Justyna M
authors.initials: JM
authors.lastname: Rak
authors.forename: Doua F
authors.initials: DF
authors.lastname: Azzouz
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Cassuto-Viguier
authors.forename: Jean
authors.initials: J
authors.lastname: Gugenheim
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Lambert
mesh_terms: D001803:Blood Transfusion; D046528:Chimerism; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D016030:Kidney Transplantation / Q000276:immunology; D011247:Pregnancy; D014019:Tissue Donors
chemical_list: D006680:HLA Antigens