title: Fertility preservation using controlled ovarian hyperstimulation and oocyte cryopreservation in a premenarcheal female with myelodysplastic syndrome.
abstract: OBJECTIVE
  To report the first case of fertility preservation in a premenarcheal female by use of controlled ovarian hyperstimulation and oocyte cryopreservation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Reproductive endocrinology and infertility unit of a tertiary care university-based medical center.
  
  
  METHODS
  A 13-year-old premenarcheal female with Tanner stage 3 breast development and Tanner stage 1 pubic hair diagnosed with myelodysplastic syndrome, referred by her medical oncologist for fertility preservation before undergoing a potentially sterilizing antineoplastic therapy.
  
  
  METHODS
  Evaluation of ovarian reserve, ovarian stimulation, transvaginal oocyte aspiration, in vitro maturation of immature oocytes, and oocyte cryopreservation.
  
  
  METHODS
  Cryopreservation of mature oocytes.
  
  
  RESULTS
  Successful controlled ovarian hyperstimulation allowed for the cryopreservation of 18 mature oocytes before the patient's gonadotoxic treatment. The oocyte retrieval and cryopreservation did not delay the patient's planned chemotherapy.
  
  
  CONCLUSIONS
  Ovarian stimulation and oocyte cryopreservation can be successfully performed in premenarcheal/peripubertal patients, thus providing a viable alternative to ovarian tissue freezing for fertility preservation in the pediatric population.
authors.affiliation: Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Reichman
authors.forename: Owen K
authors.initials: OK
authors.lastname: Davis
authors.forename: Nikica
authors.initials: N
authors.lastname: Zaninovic
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
authors.forename: Dan E
authors.initials: DE
authors.lastname: Goldschlag
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002478:Cells, Cultured; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D054315:Oocyte Retrieval; D009865:Oocytes; D010062:Ovulation Induction; D046468:Sexual Development
chemical_list: D000970:Antineoplastic Agents