title: Supramolecular hydrogel of kanamycin selectively sequesters 16S rRNA.
abstract: As the first example of hydrogelator derived from aminoglycoside antibiotics, the hydrogel of kanamycin indicates that the hydrogel of aminoglycosides preserve the specific interaction with their macromolecular targets (e.g., 16S rRNA), thus illustrating a simple approach to explore and identify possible biological targets of supramolecular nanofibers/hydrogels.
authors.affiliation: Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, PR China.
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Kuang
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Zhou
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007612:Kanamycin / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012336:RNA, Ribosomal, 16S / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D000900:Anti-Bacterial Agents; D020100:Hydrogels; D012336:RNA, Ribosomal, 16S; D007612:Kanamycin