title: Hantavirus infection prevalence in wild rodents and human anti-hantavirus serological profiles from different geographic areas of South Brazil.
abstract: Paraná state presents the fourth highest number of accumulated cases of hantavirus pulmonary syndrome in Brazil. To map the risk areas for hantavirus transmission we carried out a study based on rodent trapping and determined the anti-hantavirus seroprevalence in these animals and in the inhabitants of these localities. Overall seroprevalence in rodents and humans were 2.5% and 2.4%, respectively. Eighty-two percent of the seropositive rodents were genetically analyzed. Phylogenetic analyses revealed that hantaviruses from rodent samples cluster with Araucária (Juquitiba-like) or Jaborá hantavirus genotypes. The Jaborá strain was identified in Akodon serrensis and Akodon montensis, whereas the Araucária strain was detected in Oligoryzomys nigripes, Oxymycterus judex, A. montensis, and Akodon paranaensis, with the latter species being identified for the first time as a natural host. These findings expose the complex relationships between virus and reservoirs in Brazil, which could have an impact on hantavirus transmission dynamics in nature and human epidemiology.
authors.affiliation: Instituto Carlos Chagas, Fiocruz, Paraná, Brazil. sraboni@ufpr.br
authors.forename: Sonia M
authors.initials: SM
authors.lastname: Raboni
authors.forename: Adriana
authors.initials: A
authors.lastname: Delfraro
authors.forename: Luana
authors.initials: L
authors.lastname: de Borba
authors.forename: Bernardo R
authors.initials: BR
authors.lastname: Teixeira
authors.forename: Vanessa
authors.initials: V
authors.lastname: Stella
authors.forename: Marina R
authors.initials: MR
authors.lastname: de Araujo
authors.forename: Suzana
authors.initials: S
authors.lastname: Carstensen
authors.forename: Giselia
authors.initials: G
authors.lastname: Rubio
authors.forename: Angela
authors.initials: A
authors.lastname: Maron
authors.forename: Elba R S
authors.initials: ER
authors.lastname: Lemos
authors.forename: Paulo S
authors.initials: PS
authors.lastname: D'Andrea
authors.forename: Claudia N
authors.initials: CN
authors.lastname: Duarte dos Santos
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D017753:Ecosystem; D005838:Genotype; D006476:Orthohantavirus / Q000235:genetics / Q000302:isolation & purification*; D018804:Hantavirus Pulmonary Syndrome / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary* / Q000821:virology*; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D012376:Rodent Diseases / Q000453:epidemiology / Q000821:virology*; D012377:Rodentia; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral