title: The use of cyclosporine in dermatology.
abstract: Cyclosporine is an immunosuppressive drug that acts selectively on T-cells by inhibiting calcineurin phosphorylase. It has been used in dermatology since its approval for US Food and Drug Administration in 1997 for the use in psoriasis. While indicated only for the treatment of moderate to severe psoriasis, cyclosporine has also been used as an off-label drug for the treatment of various inflammatory skin conditions, including atopic dermatitis, blistering disorders, and connective tissue diseases. In this article, we review the use of cyclosporine in dermatology.
authors.affiliation: Florida Academic Dermatology Center, University of Miami Hospital, Miami, FL 33136, USA.
authors.forename: Luis
authors.initials: L
authors.lastname: Dehesa
authors.forename: Adriana
authors.initials: A
authors.lastname: Abuchar
authors.forename: Almudena
authors.initials: A
authors.lastname: Nuno-Gonzalez
authors.forename: Magalys
authors.initials: M
authors.lastname: Vitiello
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Kerdel
mesh_terms: D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy; D003882:Dermatomyositis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008178:Lupus Erythematosus, Cutaneous / Q000188:drug therapy; D011536:Prurigo / Q000188:drug therapy; D011565:Psoriasis / Q000188:drug therapy; D017511:Pyoderma Gangrenosum / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D016463:Sweet Syndrome / Q000188:drug therapy; D014581:Urticaria / Q000188:drug therapy
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine