title: Primary cutaneous CD8(+) small- to medium-sized lymphoproliferative disorder in extrafacial sites: clinicopathologic features and concept on their classification.
abstract: Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small- to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no association with Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small- to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small- to medium-sized lymphoid proliferations, which are characterized by an indolent course in most patients.
authors.affiliation: Kempf und Pfaltz Histologische Diagnostik, Zürich, Switzerland. werner.kempf@access.uzh.ch
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.forename: Antonio
authors.initials: A
authors.lastname: Cozzio
authors.forename: Jivko
authors.initials: J
authors.lastname: Kamarashev
authors.forename: Katrin
authors.initials: K
authors.lastname: Kerl
authors.forename: Tobias
authors.initials: T
authors.lastname: Plaza
authors.forename: Dieter
authors.initials: D
authors.lastname: Metze
mesh_terms: D000369:Aged, 80 and over; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008232:Lymphoproliferative Disorders / Q000145:classification* / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000145:classification* / Q000276:immunology / Q000473:pathology*