title: Osteopenia/osteoporosis in patients with calcium nephrolithiasis.
abstract: The objective of this study is to analyze the alterations in bone mineral density and bone and calcium-phosphorus metabolism in patients with calcium nephrolithiasis. We designed a study with 182 patients who were distributed among three groups: group O, 56 patients without nephrolithiasis; group A, 67 patients with calcium nephrolithiasis and mild lithogenic activity; and group B, 59 patients with calcium nephrolithiasis and severe lithogenic activity. Metabolic parameters of blood and urine that were related to calcium-phosphorous and bone metabolism and bone densitometry were assessed in all patients. A comparative study was performed on the variables of bone and calcium-phosphorus metabolism and bone densitometry as well as the presence or absence of osteopenia/osteoporosis. The patients in group B had a greater loss of bone mineral density, measured by the T-score, than the patients in groups O and A. Moreover, the proportion of patients in group B with osteopenia/osteoporosis was statistically significantly higher than the proportion of patients in groups O and A. We observed higher values of calciuria, fasting calcium/creatinine ratio, and 24-h calcium/creatinine among the patients in group B compared to the other two groups. Calciuria, citraturia, and fasting calcium/creatinine were independent factors that showed a relationship with severe lithogenic activity compared to the control group, and β-crosslaps is an independent factor that has a relationship with severe lithogenic activity as compared to mild lithogenic activity. Patients with calcium lithiasis and severe lithogenic activity have a greater loss in bone mineral density and therefore a greater risk of osteopenia/osteoporosis.
authors.affiliation: Urology Department, San Cecilio University Hospital, Camino de Ronda Street, 143. 4F, Granada, Spain. arrabalp@ono.com
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Arrabal-Polo
authors.forename: Miguel
authors.initials: M
authors.lastname: Arrabal-Martin
authors.forename: Maria Sierra
authors.initials: MS
authors.lastname: Girón-Prieto
authors.forename: Antonio
authors.initials: A
authors.lastname: Poyatos-Andujar
authors.forename: Juan
authors.initials: J
authors.lastname: Garrido-Gomez
authors.forename: Armando
authors.initials: A
authors.lastname: Zuluaga-Gomez
authors.forename: Salvador
authors.initials: S
authors.lastname: Arias-Santiago
mesh_terms: D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000150:complications* / Q000378:metabolism; D010024:Osteoporosis / Q000209:etiology*; D010758:Phosphorus / Q000378:metabolism
chemical_list: D010758:Phosphorus; D002118:Calcium