title: Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds.
abstract: BACKGROUND
  The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally inflicted wounds in rats.
  
  
  METHODS
  This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University.
  
  
  RESULTS
  Morin showed significant wound contraction on day 7 as compared to control with mean closure of 47.44±6.07% in excision wound model. Granulation tissue breaking strength was significantly increased (p<0.05) in the morin treated group with 180.2±7.94 g when compared to control at 151.2±6.99 g. There was a significant increase in hydroxyproline content with the morin treated group when compared to control with 3.41±0.33 μg/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing.
  
  
  CONCLUSIONS
  Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.
authors.affiliation: Department of Pharmacology, Manipal University, Manipal, India.
authors.forename: Rekha Raghuveer
authors.initials: RR
authors.lastname: Shenoy
authors.forename: Arun Theerthahalli
authors.initials: AT
authors.lastname: Sudheendra
authors.forename: Pawan Ganesh
authors.initials: PG
authors.lastname: Nayak
authors.forename: Piya
authors.initials: P
authors.lastname: Paul
authors.forename: Nampurath Gopalan
authors.initials: NG
authors.lastname: Kutty
authors.forename: Chamallamudi Mallikarjuna
authors.initials: CM
authors.lastname: Rao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D062109:Dermatologic Surgical Procedures; D003907:Dexamethasone / Q000633:toxicity*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D005938:Glucocorticoids / Q000633:toxicity*; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013718:Tensile Strength; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D047309:Flavones
chemical_list: D000975:Antioxidants; D004247:DNA; D003907:Dexamethasone; D005419:Flavonoids; D005938:Glucocorticoids; D006909:Hydroxyproline; D008249:Protein-Lysine 6-Oxidase; D012313:RNA; C008548:morin; D047309:Flavones