title: Unleashing potential: transcranial direct current stimulation over the right posterior parietal cortex improves change detection in low-performing individuals.
abstract: The limits of human visual short-term memory (VSTM) have been well documented, and recent neuroscientific studies suggest that VSTM performance is associated with activity in the posterior parietal cortex. Here we show that artificially elevating parietal activity via positively charged electric current through the skull can rapidly and effortlessly improve people's VSTM performance. This artificial improvement, however, comes with an interesting twist: it interacts with people's natural VSTM capability such that low performers who tend to remember less information benefitted from the stimulation, whereas high performers did not. This behavioral dichotomy is explained by event-related potentials around the parietal regions: low performers showed increased waveforms in N2pc and contralateral delay activity (CDA), which implies improvement in attention deployment and memory access in the current paradigm, respectively. Interestingly, these components are found during the presentation of the test array instead of the retention interval, from the parietal sites ipsilateral to the target location, thus suggesting that transcranial direct current stimulation (tDCS) was mainly improving one's ability to suppress no-change distractors located on the irrelevant side of the display during the comparison stage. The high performers, however, did not benefit from tDCS as they showed equally large waveforms in N2pc and CDA, or SPCN (sustained parietal contralateral negativity), before and after the stimulation such that electrical stimulation could not help any further, which also accurately accounts for our behavioral observations. Together, these results suggest that there is indeed a fixed upper limit in VSTM, but the low performers can benefit from neurostimulation to reach that maximum via enhanced comparison processes, and such behavioral improvement can be directly quantified and visualized by the magnitude of its associated electrophysiological waveforms.
authors.affiliation: Institute of Cognitive Neuroscience, National Central University, Jhongli 320, Taiwan.
authors.forename: Philip
authors.initials: P
authors.lastname: Tseng
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Hsu
authors.forename: Chi-Fu
authors.initials: CF
authors.lastname: Chang
authors.forename: Ovid J L
authors.initials: OJ
authors.lastname: Tzeng
authors.forename: Daisy L
authors.initials: DL
authors.lastname: Hung
authors.forename: Neil G
authors.initials: NG
authors.lastname: Muggleton
authors.forename: Vincent
authors.initials: V
authors.lastname: Walsh
authors.forename: Wei-Kuang
authors.initials: WK
authors.lastname: Liang
authors.forename: Shih-kuen
authors.initials: SK
authors.lastname: Cheng
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Juan
mesh_terms: D000704:Analysis of Variance; D001703:Biophysics; D004558:Electric Stimulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D011930:Reaction Time; D017603:Signal Detection, Psychological / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult