title: Arachidonic acid metabolites in pathogenic yeasts.
abstract: Although most of what is known about the biology and function of arachidonic acid metabolites comes from the study of mammalian biology, these compounds can also be produced by lower eukaryotes, including yeasts and other fungi. It is also in this group of organisms that the least is known about the metabolic pathways leading to the production of these compounds as well as the functions of these compounds in the biology of fungi and yeasts. This review will deal with the discovery of oxylipins from polyunsaturated fatty acids, and more specifically the arachidonic acid derived eicosanoids, such as 3-hydroxy eicosatetraenoic acid, prostaglandin F2α and prostaglandin E2, in yeasts starting in the early 1990s. This review will also focus on what is known about the metabolic pathways and/or proteins involved in the production of these compounds in pathogenic yeasts. The possible roles of these compounds in the biology, including the pathology, of these organisms will be discussed.
authors.affiliation: Department of Microbial, biochemical and food Biotechnology, University of the Free State, South Africa.
authors.forename: Ruan
authors.initials: R
authors.lastname: Ells
authors.forename: Johan Lf
authors.initials: JL
authors.lastname: Kock
authors.forename: Jacobus
authors.initials: J
authors.lastname: Albertyn
authors.forename: Carolina H
authors.initials: CH
authors.lastname: Pohl
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D053898:Biosynthetic Pathways; D015777:Eicosanoids / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D009181:Mycoses / Q000276:immunology / Q000382:microbiology; D015003:Yeasts / Q000276:immunology / Q000378:metabolism* / Q000502:physiology
chemical_list: D001095:Arachidonic Acids; D015777:Eicosanoids; D005656:Fungal Proteins