title: [Comparative study of antiviral activity of luteolin and 7,3'-disulfate luteolin].
abstract: Antiviral activity of 7,3'-disulfate luteolin, extracted from Zostera marina was studied on an experimental model of tick-borne encephalitis (TBE) in vivo and in vitro. The drug increased the survival of the experimental mice infected with TBE virus and prolonged their lifespan. It was shown that 7,3'-disulfate luteolin reduced the virus accumulation in the SPEV cells by 2.0-4.0 lg TCID50/ml.
authors.forename: N V
authors.initials: NV
authors.lastname: Krylova
authors.forename: A M
authors.initials: AM
authors.lastname: Popov
authors.forename: G N
authors.initials: GN
authors.lastname: Leonova
authors.forename: A A
authors.initials: AA
authors.lastname: Artiukov
authors.forename: O S
authors.initials: OS
authors.lastname: Maĭstrovskaia
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects / Q000821:virology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004669:Encephalitis Viruses, Tick-Borne / Q000187:drug effects; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000401:mortality / Q000821:virology; D047311:Luteolin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D035962:Zosteraceae / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; C576654:luteolin 7,3'-disulfate; D047311:Luteolin