title: CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions.
abstract: The PH domain-containing casein kinase 2 interacting protein-1 (CKIP-1, also known as PLEKHO1) acts as a scaffold protein mediating interactions with multiple proteins, including CK2α, CPα, AP-1/c-Jun, Akt, ATM, IFP35/Nmi and Smurf1. CKIP-1 functions through different ways, such as plasma membrane recruitment, transcriptional activity modulation and posttranscriptional modification regulation. Moreover, the subcellular localization of CKIP-1 is determined by several key amino acids in a cell type dependent style, and the nucleus/plasma membrane shuttle of CKIP-1 is regulated by different cell stresses. As an adaptor protein, CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation. Strikingly, CKIP-1 has been recently demonstrated to be a promising target for treatment of osteoporosis in rat models. In addition, more evidences suggest that CKIP-1 might also function as a potential tumor suppressor.
authors.affiliation: Department of Molecular Biology, Institute of Basic Medical Science, PLA General Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
authors.forename: Weidong
authors.initials: W
authors.lastname: Han
authors.forename: Lingqiang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000188:drug therapy / Q000503:physiopathology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology*; D047390:Casein Kinase II / Q000502:physiology; D002462:Cell Membrane / Q000201:enzymology / Q000502:physiology; D002467:Cell Nucleus / Q000201:enzymology / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009369:Neoplasms / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C408877:PLEKHO1 protein, human; D047390:Casein Kinase II