title: High-grade cervical neoplasia during pregnancy: diagnosis, management and postpartum findings.
abstract: OBJECTIVE
  To study the prevalence of high-grade cervical intraepithelial neoplasia (CIN 2-3) during pregnancy and compare the rates of persistence, progression and regression of CIN 2-3 by colposcopically guided biopsy during pregnancy with respect to the postpartum period. Also to assess biopsy results during pregnancy and postpartum in relation to histopathology after treatment of lesions.
  
  
  METHODS
  Pregnant women with a histological diagnosis of CIN 2-3 confirmed by colposcopically guided biopsy during pregnancy.
  
  
  METHODS
  Between 1989 and 2008, 11 700 pregnant women had cytologic and simultaneous colposcopic examinations during pregnancy. A colposcopically guided biopsy was performed when colposcopically suspicious high-grade lesions were detected, regardless of cytological results. Women with a histopathological diagnosis of CIN 2-3 during pregnancy were re-evaluated by colposcopically guided biopsy and treated during the postpartum period.
  
  
  RESULTS
  CIN 2-3 was diagnosed in 56 of 11 700 (0.48%) pregnant women by biopsy. Thirty women complying with the protocol were assessed postpartum by histopathological studies, of whom 70% exhibited persistence, 13.3% progression and 16.7% regression of CIN 2-3. Twenty-nine were diagnosed by conization and one by colposcopically guided biopsy during the postpartum period, which revealed invasive cervical carcinoma.
  
  
  CONCLUSIONS
  Due to the high rates of CIN 2-3 persistence during the postpartum period, we suggest that all patients in whom CIN 2-3 was diagnosed during pregnancy are biopsied and treated if necessary during the postpartum period, with at least a two-year follow-up control to prevent lesion recurrence.
authors.affiliation: Lower Genital Tract Clinic, Obstetrics Division, Department of Gynecology, Hospital de Clínicas José de San Martín, University Hospital of Buenos Aires, Buenos Aires, Argentina. ecopolillo@intramed.net
authors.forename: Enrique F
authors.initials: EF
authors.lastname: Coppolillo
authors.forename: Hilda Malamud
authors.initials: HM
authors.lastname: DE Ruda Vega
authors.forename: Julieta
authors.initials: J
authors.lastname: Brizuela
authors.forename: Martha Cora
authors.initials: MC
authors.lastname: Eliseth
authors.forename: Avelino
authors.initials: A
authors.lastname: Barata
authors.forename: Beatriz E
authors.initials: BE
authors.lastname: Perazzi
mesh_terms: D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology*; D016009:Chi-Square Distribution; D003127:Colposcopy; D019092:Conization; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009365:Neoplasm Regression, Spontaneous; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D015995:Prevalence; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery