title: Clinicopathological features of Churg-Strauss syndrome with severe nerve degeneration: a case report.
abstract: Churg-Strauss syndrome (CSS) is a rare autoimmune vasculitis of unknown etiology that involves small- and medium-sized blood vessels. Its onset is thought to be associated with adult-onset asthma, and vasculitis typically involves vessels in the lungs. However, due to increased blood and tissue eosinophilia, vasculitis may result in the involvement multiple systems of (neurological, skin, etc.). We report a case of CSS with manifestations that included skin purpura and severe peripheral nerve degeneration in a 56-year-old woman with a recent history of asthma. After the treatment with methylprednisolone and standard immunosuppressive therapy, her rashes resolved, there were no acute asthma attacks, and the numbness in her lower limbs improved.
authors.affiliation: Department of Neurology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jing Yan
authors.initials: JY
authors.lastname: Xiang
authors.forename: Yu Wu
authors.initials: YW
authors.lastname: Zhao
authors.forename: Jian Liang
authors.initials: JL
authors.lastname: Fu
authors.forename: Xiao Juan
authors.initials: XJ
authors.lastname: Cheng
authors.forename: Qin
authors.initials: Q
authors.lastname: Xue
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009410:Nerve Degeneration / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D011693:Purpura / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone