title: [Study on specificity of noninvasive glucose measurements based on two-dimensional correlation mid-infrared spectroscopy].
abstract: Glucose specificity is the premise of spectroscopic measurements of blood glucose concentration, and it is also paramount for feasibility study of a spectral measurement method. Two-dimensional correlation spectroscopy technology is widely used in many fields such as inter-/intra-molecular reaction, material phase transition and information extraction because of its high resolution and effective Noda's rule. In the present paper, the glucose specificity for noninvasive glucose measurements by mid-infrared spectra based on the 2D correlation spectroscopy was investigated. First, the feasibility of this method was validated by a series of in vitro experiments of glucose. Then the in vivo experiments of four volunteers were conducted and the characteristic information of glucose by mid-infrared spectra collected from human fingers was confirmed by 2D correlation spectroscopy analysis.
authors.affiliation: College of Precision Instrument & Opto-electronics Engineering, Tianjin University, Tianjin 300072, China. zw8807@tju.edu.cn
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Yu-Zhen
authors.initials: YZ
authors.lastname: Cao
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Ke-Xin
authors.initials: KX
authors.lastname: Xu
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D006801:Humans; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared
chemical_list: D001786:Blood Glucose