title: Aluminium-maltolate-induced impairment of learning, memory and hippocampal long-term potentiation in rats.
abstract: Recently, aluminium (Al) has been proposed to be one of the environmental factors responsible for cause Alzheimer's disease (AD). However, the relationship between Al and AD is controversial. To investigate the effects of subchronic Aluminium-maltolate (Al (mal)(3)) exposure on the behavioral, electrophysiological functions. Forty Sprague-Dawley (SD) rats were randomly distributed into five groups. Over two months, rats in the saline group received daily intraperitoneal (i.p.) injections 0.9% saline, rats in the maltolate group received 7.56 mg/kg maltolate, and rats in the 0.27, 0.54, 1.08 mg/kg Al (mal)(3) groups received i.p. administrations of these three doses, respectively. Neural behavior was assessed in Morris water maze. Long-term potentiation (LTP) in hippocampus was recorded. Al content in the neocortex was determined using a graphite furnace atomic absorption spectrophotometer. Our studies indicate that subchronic Al (mal)(3) exposure significantly impaired spatial learning and memory abilities, suppressed the LTP in the CA1 hippocampal area, and elevated Al levels in cerebral cortex in a dose-dependent fashion. In conclusion, low doses of Al (mal)(3) can still lead to dramatic Al accumulation in the brain, severely impair learning and memory capacities, and hippocampal LTP.
authors.affiliation: Department of Occupational Health, Shanxi Medical University, P.R. China.
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Liang
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Li
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Wang
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Jun-Xia
authors.initials: JX
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ming-Tao
authors.initials: MT
authors.lastname: Wan
authors.forename: Bao-Long
authors.initials: BL
authors.lastname: Pan
authors.forename: Qiao
authors.initials: Q
authors.lastname: Niu
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects*; D007859:Learning Disabilities / Q000139:chemically induced*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced*; D019579:Neocortex / Q000187:drug effects; D009942:Organometallic Compounds / Q000009:adverse effects*; D011753:Pyrones / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D011753:Pyrones; C067527:aluminum maltolate