title: Homeostatic mechanisms by alternative forms of tRNA synthetases.
abstract: Although aminoacyl tRNA synthetases (aaRSs) act in translation, numerous examples demonstrate ex-translational functions in fundamental networks of higher organisms. These functions involve modified versions of aaRSs and natural fragments. The interplay of aaRS-derived entities appears to be at the heart of homeostatic mechanisms controlling angiogenesis, inflammation, metabolism, and tumorigenesis.
authors.affiliation: Department of Cancer Biology, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.forename: Paul
authors.initials: P
authors.lastname: Schimmel
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D006321:Heart; D006706:Homeostasis; D006801:Humans
chemical_list: D000604:Amino Acyl-tRNA Synthetases