title: Facile Synthesis of Clickable, Water-soluble and Degradable Polyphosphoesters.
abstract: "Click" chemistry is a library of efficient and reliable reactions, which have been used to functionalize various classes of bio- and synthetic macromolecular systems for the incorporation of designed properties and functions. In this report, azide-alkyne Huisgen cycloaddition and thiol-yne reactions, two classical "click" chemistries, were employed to functionalize biodegradable, clickable polyphosphoester homopolymers and their water-soluble copolymers. A stable alkyne-functionalized phospholane monomer was synthesized, its organocatalyzed polymerization kinetics were evaluated, and the resulting (co)polymers were utilized to develop this facile method that provides the synthesis of clickable, water-soluble and degradable polyphosphoesters, which can be adapted for various applications.
authors.affiliation: Departments of Chemistry and Chemical Engineering, Texas A&M University, College Station, TX 77842.
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhang
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Jiong
authors.initials: J
authors.lastname: Zou
authors.forename: Lily Yun
authors.initials: LY
authors.lastname: Lin
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wooley