title: Factors affecting impairment of blood rheology in obese subjects.
abstract: OBJECTIVE
  Impairment of blood rheology has been reported to be associated with cardiovascular diseases. Recently, visible micro channel methods [micro channel array flow analyzer (MC-FAN)] have been developed to clinically evaluate blood rheology. The aim of this cross-sectional study is to clarify the factors important for impairment of blood rheology in obese subjects using MC-FAN.
  
  
  METHODS
  One hundred and fifty-nine obese subjects and 100 non-obese subjects with no history of cardiovascular diseases were enrolled. Blood passage time (BPT) was measured using MC-FAN and relationships between BPT and various clinical parameters were examined.
  
  
  RESULTS
  BPT was significantly higher in obese subjects than in non-obese subjects (obesity vs. non-obesity: 62.8 ± 17.9s vs. 54.1 ± 14.6s, p<0.001); however, there were no significant relationships between BPT and body mass index or waist circumference in obese subjects. BPT was significantly related to systolic blood pressure levels (r=0.21; p<0.001), high-sensitivity C-reactive protein concentrations (r=0.37; p<0.001), a marker of inflammation, and derivatives of reactive oxygen metabolites test (r=0.38; p<0.001), a marker of oxidative stress, smoking, and exercise habits in obese subjects. Furthermore, multivariate analysis revealed that derivatives of reactive oxygen metabolites test (t=5.2; p<0.001), high sensitivity C-reactive protein concentration (t=3.6; p<0.01), smoking (t=3.2; p<0.001), and exercise habits (t=-2.4; p<0.05) were independent variables for BPT.
  
  
  CONCLUSIONS
  Data indicate that inflammation, oxidative stress, and lifestyle choices are more important factors for impairment of blood rheology, which is evaluated by MC-FAN, than the degree of adiposity in obese subjects.
authors.affiliation: Hitsumoto Medical Clinic, Shimonoseki, Japan. thitsu@jcom.home.ne.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hitsumoto
mesh_terms: D050154:Adiposity / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D012212:Rheology / Q000295:instrumentation*; D013599:Systole
chemical_list: D002097:C-Reactive Protein