title: Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.
abstract: The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zang
authors.forename: Salim
authors.initials: S
authors.lastname: Javed
authors.forename: David
authors.initials: D
authors.lastname: Hill
authors.forename: Farman
authors.initials: F
authors.lastname: Ullah
authors.forename: Danse
authors.initials: D
authors.lastname: Bi
authors.forename: Patrick
authors.initials: P
authors.lastname: Porubsky
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Conrad
authors.initials: C
authors.lastname: Santini
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D001331:Automation; D001372:Aza Compounds / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry*
chemical_list: C545228:1,4-diazepane; D001372:Aza Compounds; D001381:Azepines; D054852:Small Molecule Libraries; D013455:Sulfur