title: Pyrazine derivatives: a patent review (2008 - present).
abstract: BACKGROUND
  Pyrazines derivatives are well-known and important two-nitrogen-containing six-membered ring aromatic heterocyclic compounds and can carry substituents at one or more of the four ring carbon atoms. Pyrazines are a class of compounds that occur in nature and various methods have been worked out for their synthesis. A large number of pyrazine derivatives have been found to possess diverse pharmacological properties, which has caused an increasing interest by researchers in this core.
  
  
  METHODS
  This review provides a comprehensive review of the pyrazines derivatives patented between the years 2008 to 2012 as potential active compounds. The patent databases SciFinder and esp@cenet were used to locate patent applications that were published between 2008 to present. Information from articles published was also included.
  
  
  CONCLUSIONS
  The diversity of pyrazines derivatives found in organisms in nature with different applications began to arouse the interest of research in this nucleus. The pyrazines derivatives have numerous prominent pharmacological effects, such as antibacterial, antifungal, antimycobacterial, anti-inflammatory, analgesic, anticancer for different types, antidiabetic, treatment for arteriosclerosis, antiviral. It's the time to conduct further studies aimed at rationalizing the biological activities found in order to develop more effective and clinically interesting compounds.
authors.affiliation: Universidade Federal do Rio de Janeiro, Chemistry Institute, Department of Organic Chemistry, 27930-560, Mácae-RJ, Brazil.
authors.forename: Sabrina Baptista
authors.initials: SB
authors.lastname: Ferreira
authors.forename: Carlos Roland
authors.initials: CR
authors.lastname: Kaiser
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D010330:Patents as Topic; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011719:Pyrazines