title: Hippo inactivation feeds tumor-initiating cells.
abstract: The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In a study published in Cell, Cordenonsi and colleagues link TAZ, a downstream effector of the Hippo pathway, to attributes of putative breast cancer stem cells, epithelial-to-mesenchymal transition and cell polarity.
authors.forename: Stephan
authors.initials: S
authors.lastname: Duss
authors.forename: Adrian
authors.initials: A
authors.lastname: Britschgi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bentires-Alj
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D004789:Enzyme Activation; D005260:Female; D000090683:Hippo Signaling Pathway; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D017346:Protein Serine-Threonine Kinases