title: A porcine model of familial adenomatous polyposis.
abstract: We created gene-targeted pigs with mutations in the adenomatous polyposis coli (APC) gene (APC) that are orthologous to those responsible for human familial adenomatous polyposis (FAP). One-year-old pigs with the APC(1311) mutation (orthologous to human APC(1309)) have aberrant crypt foci and low- and high-grade dysplastic adenomas in the large intestine, similar to the precancerous lesions that develop in patients with FAP. Dysplastic adenomas accumulate β-catenin and lose heterozygosity of APC. This large-animal, genetic model of FAP will be useful in the development of diagnostics and therapeutics for colorectal cancer. DNA sequence data: NCBI accession number GU951771.
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Flisikowska
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Merkl
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Landmann
authors.affiliation: Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Eser
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Nousin
authors.initials: N
authors.lastname: Rezaei
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Cui
authors.affiliation: Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Kurome
authors.affiliation: Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
authors.forename: Valeri
authors.initials: V
authors.lastname: Zakhartchenko
authors.affiliation: Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kessler
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Hagen
authors.initials: H
authors.lastname: Wieland
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Oswald
authors.initials: O
authors.lastname: Rottmann
authors.affiliation: Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
authors.forename: Roland M
authors.initials: RM
authors.lastname: Schmid
authors.affiliation: Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
authors.forename: Günter
authors.initials: G
authors.lastname: Schneider
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kind
authors.affiliation: Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Wolf
authors.affiliation: Klinikum Rechts der Isar II, Technische Universität München, Munich, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Saur
authors.affiliation: Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany. Electronic address: schnieke@wzw.tum.de.
authors.forename: Angelika
authors.initials: A
authors.lastname: Schnieke
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D017491:Genes, APC; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D013552:Swine; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051176:beta Catenin