title: Primary cutaneous gamma delta T-cell lymphoma with brain involvement and hemophagocytic syndrome.
abstract: Primary cutaneous gamma delta T-cell lymphoma is a rare diagnosis with only 40 reported cases. We describe a case of cutaneous gamma delta T-cell lymphoma with hemophagocytic syndrome and brain involvement that was not apparent morphologically on skin biopsy and was diagnosed as perifolliculitis and lobular panniculitis. The biopsy was sent later for molecular studies to the University of Washington, which demonstrated a T-cell clone. This case demonstrates that a T-cell clone may be present in a skin biopsy without morphologic or immunophenotypic evidence of lymphoma.
authors.affiliation: Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA. laueran@ohsu.edu
authors.forename: Andrea
authors.initials: A
authors.lastname: Chakrapani
authors.forename: Anne
authors.initials: A
authors.lastname: Avery
authors.forename: Roger
authors.initials: R
authors.lastname: Warnke
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta