title: Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma.
abstract: Chemokine/chemokine receptor interactions play a critical role in lymphocyte infiltration of tumors. Recent studies suggest that Th17 cells accumulate within many types of tumors, although the mechanisms that control this are unclear. We studied the distribution and phenotypic features of Th17 cells chemokine receptors, as well as the mRNA levels of CCL2, CCL17, CCL20, and CCL22 in tumors of patients with esophageal squamous cell carcinoma. We found that Th17 cells accumulated in tumors, and high expressions of CCR4, CCR6 were detected in Th17 cells. Levels of the chemokines CCL17, CCL20, and CCL22 in tumors were significantly higher than in tumor-free tissues, and were positively correlated with the distribution of Th17 cells in tumors. Furthermore, an in vitro migration assay showed that CCL17, CCL20 and CCL22 had chemotactic effects on tumor-derived Th17 cells. In conclusion, the CCR4-CCL17/22 and CCR6-CCL20 axis might play an important role in Th17 cell infiltration of tumors.
authors.affiliation: Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. cdeyu@hotmail.com
authors.forename: Deyu
authors.initials: D
authors.lastname: Chen
authors.forename: Riyue
authors.initials: R
authors.lastname: Jiang
authors.forename: Chaoming
authors.initials: C
authors.lastname: Mao
authors.forename: Liang
authors.initials: L
authors.lastname: Shi
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wang
authors.forename: Lichao
authors.initials: L
authors.lastname: Yu
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.forename: Dongfang
authors.initials: D
authors.lastname: Dai
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism / Q000401:mortality; D018925:Chemokines / Q000276:immunology / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000401:mortality; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011485:Protein Binding; D054390:Receptors, CCR2 / Q000378:metabolism; D054398:Receptors, CCR4 / Q000378:metabolism; D054399:Receptors, CCR6 / Q000378:metabolism; D019707:Receptors, Chemokine / Q000276:immunology / Q000378:metabolism*; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D018925:Chemokines; D054390:Receptors, CCR2; D054398:Receptors, CCR4; D054399:Receptors, CCR6; D019707:Receptors, Chemokine