title: Coagulation assessment in normal pregnancy: thrombelastography with citrated non activated samples.
abstract: BACKGROUND
  Thrombelastography (TEG) provides an effective and convenient means of whole blood coagulation monitoring. TEG evaluates the elastic properties of whole blood and provides a global assessment of hemostatic function. Previous studies performed TEG on native blood sample, but no data are available with citrated samples in healthy pregnant women at term. The aim of this study was to investigate the effect of pregnancy on coagulation assessed by TEG and establish normal ranges of TEG values in pregnant women at term comparing them with healthy non pregnant young women.
  
  
  METHODS
  We enrolled pregnant women at term undergoing elective cesarean section or labour induction (PREG group) and healthy non-pregnant women (CTRL group). Women with fever or inflammatory syndrome, defined as C-reactive protein (CRP) >5 mg/L and with a platelet count <150.000/mm(3) have been excluded. For each women hemochrome and standard coagulation test were assessed. At the same time we performed a thrombelastographic test with Hemoscope TEG(®) after sample recalcification without using any activator.
  
  
  RESULTS
  One hundred thirty patients were studied, 65 for each group. There were no differences between groups regarding demographic data. Hemoglobin, platelet count, International Normalized Ratio and Activated Partial Thromboplastin Time Ratio were lower and fibrinogen was higher in PREG group. All TEG parameters resulted as being significantly different between the groups with a hypercoagulable pattern in PREG group compared to CTRL group.
  
  
  CONCLUSIONS
  The main findings of this study confirm the hypercoagulability status of pregnant women at term. This coagulation pattern is well represented by thrombelastographic trace obtained by recalcified citrate blood sample.
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, University of Udine, Udine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Della Rocca
authors.forename: T
authors.initials: T
authors.lastname: Dogareschi
authors.forename: T
authors.initials: T
authors.lastname: Cecconet
authors.forename: S
authors.initials: S
authors.lastname: Buttera
authors.forename: A
authors.initials: A
authors.lastname: Spasiano
authors.forename: P
authors.initials: P
authors.lastname: Nadbath
authors.forename: M
authors.initials: M
authors.lastname: Angelini
authors.forename: C
authors.initials: C
authors.lastname: Galluzzo
authors.forename: D
authors.initials: D
authors.lastname: Marchesoni
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests / Q000379:methods*; D002951:Citrates / Q000737:chemistry*; D005260:Female; D063285:Fibrin Clot Lysis Time; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D019934:International Normalized Ratio; D010314:Partial Thromboplastin Time; D011247:Pregnancy / Q000097:blood*; D013916:Thrombelastography / Q000379:methods*
chemical_list: D002951:Citrates; D005340:Fibrinogen