title: Highly enantioselective Friedel-Crafts alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters catalyzed by heteroarylidene-tethered bis(oxazoline) copper complexes.
abstract: The simple and cheap chiral catalyst, heteroarylidene-tethered Ph-bis(oxazoline)-Cu(OTf)(2), can efficiently catalyze the asymmetric F-C alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters. The 3-indolyl adducts were obtained in up to >99% ee. Moreover, the 2-pyrrolyl adducts were achieved in up to 92% ee for the first time.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, Beijing, 100193, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Hongli
authors.initials: H
authors.lastname: Ma
authors.forename: Yumei
authors.initials: Y
authors.lastname: Xiao
authors.forename: Fengpei
authors.initials: F
authors.lastname: Du
authors.forename: Zhaohai
authors.initials: Z
authors.lastname: Qin
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Fu