title: Vitamin D status in children with Hashimoto thyroiditis.
abstract: OBJECTIVE
  To investigate vitamin D status in children with Hashimoto thyroiditis.
  
  
  METHODS
  The study group consisted of 78 children recently diagnosed as Hashimoto thyroiditis and 74 subjects as the control group. Parameters of calcium metabolism, thyroid function tests, and 25-hydroxyvitamin D [25(OH)D] levels were measured.
  
  
  RESULTS
  Vitamin D deficiency rate was significantly higher in the Hashimoto group compared with the control subjects (73.1% vs. 17.6%, p < 0.0001). In the Hashimoto group, mean 25(OH)D levels were significantly lower compared with the control group (31.2 +/- 11.5 versus 57.9 +/- 19.7 nmol/L, p < 0.001) and was inversely correlated with the anti-thyroid peroxidase (anti-TPO) levels (r = -0.30, p = 0.007).
  
  
  CONCLUSIONS
  The higher vitamin D deficiency rates besides lower vitamin D levels in the Hashimoto group together with the inverse correlation between vitamin D and anti-TPO suggest that vitamin D deficiency may have a role in the autoimmune process in Hashimoto thyroiditis in children.
authors.affiliation: Department of Pediatric Endocrinology, School of Medicine, Gazi University, Ankara, Turkey. turkalpo@yahoo.com
authors.forename: Orhun M
authors.initials: OM
authors.lastname: Camurdan
authors.forename: Esra
authors.initials: E
authors.lastname: Döğer
authors.forename: Aysun
authors.initials: A
authors.lastname: Bideci
authors.forename: Nurullah
authors.initials: N
authors.lastname: Celik
authors.forename: Peyami
authors.initials: P
authors.lastname: Cinaz
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; D013972:Thyrotropin; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D013974:Thyroxine; D002118:Calcium