title: F2-Isoprostanes in soft oral tissues and degree of oral disability after mandibular third molar surgery.
abstract: OBJECTIVE
  The aim of this study was to test the value of F(2)-isoprostane (F(2)-IsoP) levels in the pericoronal gingiva as a potential predictor of oral disability after mandibular third molar (M3M) surgery.
  
  
  METHODS
  Thirteen patients (5 male, 8 female) with partially impacted M3M were enrolled. Pericoronal soft tissues histology was obtained, gingival F(2)-IsoPs were measured by gas chromatography/negative-ion chemical ionization tandem mass spectrometry, and health-related quality of life (HRQOL) scores were assessed.
  
  
  RESULTS
  A variable degree of pericoronitis was evident before the M3M surgery, with a mean level of pericoronal F(2)-IsoPs of 634.8 ± 193.5 pg/mg of tissue. A significant positive correlation between pericoronal F(2)-IsoPs and HRQOL was observed in male (r(s) = 0.440; P = .0011), but not female (r(s) = -0.062; P = .5124) patients.
  
  
  CONCLUSIONS
  Levels of F(2)-IsoPs in the pericoronal soft tissues are correlated with the degree of oral disability after M3Ms surgery in male, but not female, patients.
authors.affiliation: Tuscan School of Dental Medicine, University of Siena, Policlinico Le Scotte Viale M, Bracci, 16, I-53100 Siena, Italy. parriniste@unisi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Parrini
authors.forename: Glauco
authors.initials: G
authors.lastname: Chisci
authors.forename: Silvia
authors.initials: S
authors.lastname: Leoncini
authors.forename: Cinzia
authors.initials: C
authors.lastname: Signorini
authors.forename: Nila
authors.initials: N
authors.lastname: Volpi
authors.forename: Aniello
authors.initials: A
authors.lastname: Capuano
authors.forename: Lucia
authors.initials: L
authors.lastname: Ciccoli
authors.forename: Claudio
authors.initials: C
authors.lastname: De Felice
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D002849:Chromatography, Gas; D004487:Edema / Q000209:etiology; D028441:F2-Isoprostanes / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000378:metabolism* / Q000473:pathology; D006209:Halitosis / Q000209:etiology; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008409:Mastication / Q000502:physiology; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000209:etiology; D011183:Postoperative Complications; D019106:Postoperative Hemorrhage / Q000209:etiology; D020250:Postoperative Nausea and Vomiting / Q000209:etiology; D011788:Quality of Life; D016059:Range of Motion, Articular / Q000502:physiology; D012737:Sex Factors; D013060:Speech / Q000502:physiology; D013529:Surgical Wound Dehiscence / Q000209:etiology; D053719:Tandem Mass Spectrometry; D013651:Taste Disorders / Q000209:etiology; D014095:Tooth, Impacted / Q000601:surgery*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis; D055815:Young Adult
chemical_list: D028441:F2-Isoprostanes; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A