title: Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives.
abstract: On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1-12 and 18-50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 19 and 27 displayed higher activity than commercial Ribavirin, thus emerging as potential inhibitors of plant virus. The novel concise structure provides another new template for antiviral studies.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry,  Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.forename: Xu
authors.initials: X
authors.lastname: Xizhi
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Liu
authors.forename: Lizhong
authors.initials: L
authors.lastname: Wang
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D012367:RNA, Viral / Q000187:drug effects; D012254:Ribavirin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D010616:Phenanthrenes; D010618:Phenanthrolines; D012367:RNA, Viral; C473343:antofine; C031181:phenanthrene; D012254:Ribavirin