title: Survivin--prognostic tumor biomarker in human neoplasms--review.
abstract: Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic marker seems to be survivin. Many studies have shown that survivin is strongly expressed in a vast majority of cancers. Its overexpression was demonstrated in breast and lung cancer prostate, gastric, colon, bladder and esophageal carcinomas, osteosarcomas, and lymphomas. In many of those tumors, high activity of the surviving gene was associated with a poor prognosis and worse survival rates. Moreover survivin expression was correlated with resistance to chemotherapy and radiotherapy-induced apoptosis. Since survivin may be identified as an independent prognostic factor and inhibitor of apoptosis, it may prove to be a useful therapeutic target in cancer therapy
authors.affiliation: Deparment of Endocrinology, Metabolism and Intemnal Diseases, University of Medical Sciences in Poznan, Poland. joanna.stachura@gmail.com
authors.forename: Joanna
authors.initials: J
authors.lastname: Waligórska-Stachura
authors.forename: Anna
authors.initials: A
authors.lastname: Jankowska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Waśko
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Liebert
authors.forename: Maciej
authors.initials: M
authors.lastname: Biczysko
authors.forename: Agata
authors.initials: A
authors.lastname: Czarnywojtek
authors.forename: Daria
authors.initials: D
authors.lastname: Baszko-Błaszyk
authors.forename: Violet
authors.initials: V
authors.lastname: Shimek
authors.forename: Marek
authors.initials: M
authors.lastname: Ruchała
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin