title: Doxorubicin-loaded Zein in situ gel for interstitial chemotherapy.
abstract: A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang 050018, PR China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Cao
authors.forename: Jianning
authors.initials: J
authors.lastname: Geng
authors.forename: Suwen
authors.initials: S
authors.lastname: Su
authors.forename: Linan
authors.initials: L
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Xie
authors.forename: Shaomei
authors.initials: S
authors.lastname: Wu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Sun
authors.forename: Zibin
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D005782:Gels / Q000737:chemistry*; D051379:Mice; D008954:Models, Biological; D015028:Zein / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D005782:Gels; D004317:Doxorubicin; D015028:Zein