title: The impact of simple orchiectomy on semen quality and endocrine parameters in postpubertal cryptorchid men.
abstract: OBJECTIVE
  The main objectives of this retrospective cohort study were to evaluate reproductive endocrine and semen profiles before and after simple orchiectomy in patients with unilateral postpubertal cryptorchidism and to investigate the relationship between hormone levels and histopathology of the removed testis.
  
  
  METHODS
  We evaluated 40 adult males who were admitted to our clinic, between 2001 and 2007, with unilateral undescended testis. Right orchiectomy was performed in 27 patients and left orchiectomy in 13. Semen analysis, serum inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were examined in before and 3 months after orchiectomy. Orchiectomy materials were evaluated histopathologically.
  
  
  RESULTS
  Semen parameters, as well as testosterone and LH levels, did not change in any histopathological subgroups in the postoperative follow-up. In patients with maturation arrest, mean serum inhibin B level statistically significantly decreased from 160.9 to 83.5 pg/ml, and mean FSH level significantly increased from 4.8 to 7.6 mIU/ml after orchiectomy (p value, 0.008 and 0.008, respectively). Though, the levels were still within the normal range of the two hormones.
  
  
  CONCLUSIONS
  Simple orchiectomy does not have any effect on semen parameters and testosterone level in patients with postpubertal cryptorchidism. The change in inhibin B and FSH levels after orchiectomy in patients with maturation arrest is not clinically significant.
authors.affiliation: Department of Urology, Gulhane Military Medical Academy, 06018, Ankara, Turkey. hcirkilata@hotmail.com
authors.forename: Hasan Cem
authors.initials: HC
authors.lastname: Irkilata
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Kibar
authors.forename: Seref
authors.initials: S
authors.lastname: Basal
authors.forename: Bulent
authors.initials: B
authors.lastname: Kurt
authors.forename: Armagan
authors.initials: A
authors.lastname: Gunal
authors.forename: Bilal Fırat
authors.initials: BF
authors.lastname: Alp
authors.forename: Ender
authors.initials: E
authors.lastname: Oral
authors.forename: Ugur
authors.initials: U
authors.lastname: Musabak
authors.forename: Lutfu
authors.initials: L
authors.lastname: Tahmaz
authors.forename: Murat
authors.initials: M
authors.lastname: Dayanc
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003456:Cryptorchidism / Q000097:blood* / Q000601:surgery*; D006801:Humans; D008297:Male; D009919:Orchiectomy; D012189:Retrospective Studies; D055101:Semen Analysis; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone