title: Magnetic nanoparticles and thermally responsive polymer for targeted hyperthermia and sustained anti-cancer drug delivery.
abstract: A novel cancer treatment method is being designed using a combination of iron oxide (Fe(3)O(4)) nanoparticles (IONPs) and Pluronic F-127 (PF127). IONPs have been used for heating tumors via an alternating electromagnetic (AEM) field. PF127 is a polymer possessing thermo-reversible and concentration-dependent gelation properties in aqueous solutions. PF127, as a gel, is an attractive drug delivery vehicle due to its zero-order drug release property. The combination of IONPs and PF127 would allow both short-term, tumor-specific, hyperthermic treatment, and long-term sustained drug delivery. As a preliminary study, the gelling and heating properties of IONPs/PF127 mixtures were investigated: 18% (w/w) PF127 was found to be ideal for our purpose because it gels at 28.0°C, i.e., it would be injectable at room temperature (20-25°C) and forms gel upon injection into the body (37°C). IONPs in PF127 showed little effect on gelation temperatures. The heating performance of IONPs in PF127 slightly, but linearly decreased with PF127. In the IONP concentration range of 0.01-0.05% (w/v) mixed with PF127 at 18% (w/w), the heating performance increased linearly with the increase in IONP concentration.
authors.affiliation: DuPont Manual High School, Louisville, KY, USA.|Chemical Engineering Department, University of Louisville, Louisville, KY, 40292, USA.
authors.forename: Sarah Y
authors.initials: SY
authors.lastname: Wang
authors.affiliation: DuPont Manual High School, Louisville, KY, USA.|Chemical Engineering Department, University of Louisville, Louisville, KY, 40292, USA.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Liu
authors.affiliation: Chemical Engineering Department, University of Louisville, Louisville, KY, 40292, USA. kyung.kang@louisville.edu.
authors.forename: Kyung A
authors.initials: KA
authors.lastname: Kang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005079:Excipients / Q000008:administration & dosage; D005290:Ferric Compounds / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced; D008280:Magnetics; D053758:Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000628:therapy*; D020442:Poloxamer / Q000008:administration & dosage*; D011108:Polymers / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D005079:Excipients; D005290:Ferric Compounds; D011108:Polymers; D020442:Poloxamer; C000499:ferric oxide