title: Motor and non-motor inhibition in the Go/NoGo task: an ERP and fMRI study.
abstract: The contribution of movement-related activity to Go/NoGo ERP differences has been debated for 25 years. In this study, we examined ERP and fMRI measures of activity in twenty adults performing non-motor (count) and motor (right-handed button press) trials of the Go/NoGo task. Task performance was highly accurate and similar in the ERP and fMRI environments. No significant task-related effects were observed for the N2 component; however, we observed a substantial increase in positivity for Press NoGo compared to Count NoGo trials. The fMRI results also revealed significant deactivations for Press NoGo relative to Count NoGo trials in several left-lateralised motor-related areas, including the inferior frontal gyrus, precentral gyrus and supplementary motor area. Together, the results indicate that the P3 NoGo>Go effect in motor tasks is caused not by movement-related negativity on Go trials but by inhibition-related positivity on NoGo trials, and that this is associated with deactivation of motor areas involved in the Go response.
authors.affiliation: School of Psychology, Centre for Brain and Mental Health Research, University of Newcastle, Australia. janette.smith@unsw.edu.au
authors.forename: Janette L
authors.initials: JL
authors.lastname: Smith
authors.forename: Sharna
authors.initials: S
authors.lastname: Jamadar
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Provost
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Michie
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D001931:Brain Mapping; D003463:Cues; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology
chemical_list: D010100:Oxygen