title: Gender differences in pulmonary and immune response in acute experimental endotoxicosis.
abstract: Differences in the immune and inflammatory response were revealed in the lungs of male and female Wistar rats on day 1 after administration of LPS in a dose inducing the development of acute bacterial endotoxemia. Females showed more pronounced morphofunctional signs of immune system activation than males: this was characterized by more severe accidental involution of the thymus, devastation of the splenic white pulp, and enhanced production of IL-4, IL-12, and TNF-α by splenocytes. In males, production of the above cytokines decreased and inflammation in the lungs was more pronounced at these terms.
authors.affiliation: Laboratory for Immunomorphology of Inflammation, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. morfolhum@mail.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Kosyreva
authors.forename: E Yu
authors.initials: EY
authors.lastname: Simonova
authors.forename: O V
authors.initials: OV
authors.lastname: Makarova
mesh_terms: D000818:Animals; D019446:Endotoxemia / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D018664:Interleukin-12 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D015847:Interleukin-4