title: Complications of Bioglue postsurgery for aortic dissections and aortic valve replacement.
abstract: OBJECTIVE
  Bioglue is an adhesive used during cardiovascular surgery to improve hemostasis perioperatively and to strengthen and reinforce vascular anastomoses. It has also been used to 'seal' the false lumen in patients presenting with acute aortic dissections. Herein, we examine the complications of Bioglue, which may lead to redo sternotomy in selected patients.
  
  
  METHODS
  A review of pathology records at our institution from 2002 to 2010 found 4 cases of excised aortic tissue and/or aortic valves with previous Bioglue use at initial operation. Excised tissues and valves were examined, looking for the presence of Bioglue, inflammatory cells (acute, chronic, macrophage and giant cells) and micro-organisms. Patient demographics were also reviewed and recorded.
  
  
  RESULTS
  We identified four cases of Bioglue use found at redo surgery, after the formation of pseudoaneurysm (n=3) and aortic stenosis (n=1). Mean interval to redo surgery was 2.28 + 0.32 years (range 2-2.6 years). Pseudoaneurysm formation was thought to be caused by an inflammatory reaction to the Bioglue itself in two cases, while one case found no such reaction. One patient with previous aortic valve replacement had large annular abscesses filled with necrotic debris surrounding the prosthesis and pannus found on the sewing cuff, comprised of Bioglue itself.
  
  
  CONCLUSIONS
  The mechanisms leading to these complications include mechanical strain, inflammation and tissue necrosis. The judicious use of Bioglue when clinically indicated, and close follow-up of these patients with serial imaging, remain an integral part of avoiding future complications.
authors.affiliation: Department of Cardiology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Adriana
authors.initials: A
authors.lastname: Luk
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
authors.forename: Jagdish
authors.initials: J
authors.lastname: Butany
mesh_terms: D000784:Aortic Dissection / Q000473:pathology / Q000601:surgery*; D017541:Aneurysm, False / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D001019:Aortic Rupture / Q000473:pathology / Q000601:surgery*; D001021:Aortic Valve / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000187:drug effects / Q000473:pathology; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D011183:Postoperative Complications; D011506:Proteins / Q000009:adverse effects*; D014945:Wound Healing / Q000187:drug effects
chemical_list: C472676:Bio-glue; D011506:Proteins