title: Involvement of AMPA receptors in CSD-induced impairment of LTP in the hippocampus.
abstract: OBJECTIVE
  To investigate the alteration of hippocampal long-term plasticity and basal synaptic transmission induced by repetitive cortical spreading depressions (CSDs).
  
  
  BACKGROUND
  There is a relationship between migraine aura and amnesia attack. CSD, a state underlying migraine attacks, may be responsible for hippocampus-related symptoms. However, the precise role of CSD on hippocampal activity has not been investigated.
  
  
  METHODS
  Male Wistar rats were divided into CSD and control groups. Repetitive CSDs were induced in vivo by topical application of solid KCl. Forty-five minutes later, the ipsilateral hippocampus was removed, and hippocampal slices were prepared for a series of electrophysiological studies.
  
  
  RESULTS
  Repetitive CSDs led to a decrease in the magnitude of long-term potentiation in the hippocampus. CSD also reduced hippocampal synaptic efficacy, as shown by a reduction in post-synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor responses. In contrast, the post-synaptic N-methyl-d-aspartate receptor responses remained unchanged. In addition, there were no changes in paired-pulse profiles between the groups, indicating that CSD did not induce any presynaptic alterations.
  
  
  CONCLUSIONS
  These findings suggest that a reduction of post-synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor responses is the mechanism responsible for impaired hippocampal long-term potentiation induced by CSD.
authors.affiliation: Department of Physiology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok, Thailand.
authors.forename: Montree
authors.initials: M
authors.lastname: Maneepark
authors.forename: Anan
authors.initials: A
authors.lastname: Srikiatkhachorn
authors.forename: Saknan
authors.initials: S
authors.lastname: Bongsebandhu-phubhakdi
mesh_terms: D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D009924:Organ Culture Techniques; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA