title: Molecular imaging using Nanobodies: a case study.
abstract: Molecular imaging is a noninvasive method to measure specific biological processes in animal models and patients using imaging. In recent years there has been a tremendous evolution in hardware and software for imaging purposes. This progress has created an urgent need for new labeled targeted molecular probes. The unique physicochemical and pharmacokinetic properties of Nanobodies match the requirements of the ideal molecular imaging tracer. Preclinical studies show strong and specific targeting in vivo with rapid clearance of unbound probe resulting in high contrasted images at early time points after intravenous administration. These data suggest that the Nanobody platform might become a generic method for the development of next generation molecular imaging probes.
authors.affiliation: In Vivo Cellular and Molecular Imaging (ICMI) Laboratory, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
authors.forename: Nick
authors.initials: N
authors.lastname: Devoogdt
authors.forename: Catarina
authors.initials: C
authors.lastname: Xavier
authors.forename: Sophie
authors.initials: S
authors.lastname: Hernot
authors.forename: Ilse
authors.initials: I
authors.lastname: Vaneycken
authors.forename: Matthias
authors.initials: M
authors.lastname: D'Huyvetter
authors.forename: Jens
authors.initials: J
authors.lastname: De Vos
authors.forename: Sam
authors.initials: S
authors.lastname: Massa
authors.forename: Patrick
authors.initials: P
authors.lastname: De Baetselier
authors.forename: Vicky
authors.initials: V
authors.lastname: Caveliers
authors.forename: Tony
authors.initials: T
authors.lastname: Lahoutte
mesh_terms: D000818:Animals; D003947:Diagnostic Techniques, Radioisotope; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D061905:Single-Domain Antibodies
chemical_list: D061905:Single-Domain Antibodies