title: Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.
abstract: Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficient aphakia mouse suggest that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing novel insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon in normal as well as diseased brains.
authors.affiliation: Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. avasudevan@mclean.harvard.edu
authors.forename: Anju
authors.initials: A
authors.lastname: Vasudevan
authors.forename: Chungkil
authors.initials: C
authors.lastname: Won
authors.forename: Suyan
authors.initials: S
authors.lastname: Li
authors.forename: Ferenc
authors.initials: F
authors.lastname: Erdélyi
authors.forename: Gábor
authors.initials: G
authors.lastname: Szabó
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001035:Aphakia / Q000235:genetics; D001973:Bromodeoxyuridine; D002465:Cell Movement / Q000502:physiology*; D059290:Dopaminergic Neurons / Q000378:metabolism*; D059330:GABAergic Neurons / Q000502:physiology*; D018398:Homeodomain Proteins; D007150:Immunohistochemistry; D008636:Mesencephalon / Q000196:embryology*; D051379:Mice; D008817:Mice, Mutant Strains; D014157:Transcription Factors / Q000172:deficiency
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; C433629:homeobox protein PITX3; D001973:Bromodeoxyuridine