title: New strategy in hepatic metastatic colorectal cancer: tomotherapy and capecitabine followed by hepatic surgical resection.
abstract: The majority of patients who develop liver metastases in metastatic colorectal cancer (mCRC) has often unresectable disease. Several new methods of nonsurgical ablation have been tested with variable success. Helical tomotherapy (HT), such as intensity-modulated radiation therapy (IMRT) or stereotactic body radiotherapy therapy, is a recent radiation therapy technique which can provide simultaneous and precise targeting of multiple lesions, while sparing normal tissues. We retrospectively assess the feasibility and the tolerance of IMRT with capecitabine followed by hepatic surgery in mCRC patients. This original observation suggests that HT could be safely integrated in the multidisciplinary management of patients with metastatic colorectal cancer as an alternative to surgery or other local ablation therapies.
authors.affiliation: Department of Medical Oncology, Institut Curie, Université Paris Descartes, 26 rue d'Ulm, 75248, Paris Cedex 05, France. wulfran.cacheux@curie.net
authors.forename: W
authors.initials: W
authors.lastname: Cacheux
authors.forename: M A
authors.initials: MA
authors.lastname: Bollet
authors.forename: V
authors.initials: V
authors.lastname: Servois
authors.forename: S
authors.initials: S
authors.lastname: Zefkili
authors.forename: F
authors.initials: F
authors.lastname: Farkhondeh
authors.forename: B
authors.initials: B
authors.lastname: Baranger
authors.forename: P
authors.initials: P
authors.lastname: Mariani
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000069287:Capecitabine; D002277:Carcinoma / Q000556:secondary / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil