title: Lab-chip HPLC with integrated droplet-based microfluidics for separation and high frequency compartmentalisation.
abstract: We demonstrate the integration of a droplet-based microfluidic device with high performance liquid chromatography (HPLC) in a monolithic format. Sequential operations of separation, compartmentalisation and concentration counter were conducted on a monolithic chip. This describes the use of droplet-based microfluidics for the preservation of chromatographic separations, and its potential application as a high frequency fraction collector.
authors.affiliation: Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Soong-Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Dong-Ku
authors.initials: DK
authors.lastname: Kang
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Edel
authors.forename: Soo-Ik
authors.initials: SI
authors.lastname: Chang
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: deMello
authors.forename: Danny
authors.initials: D
authors.lastname: O'Hare
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D004867:Equipment Design; D016650:Fluorescein-5-isothiocyanate / Q000302:isolation & purification; D005456:Fluorescent Dyes / Q000302:isolation & purification; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*
chemical_list: D005456:Fluorescent Dyes; D016650:Fluorescein-5-isothiocyanate