title: Transplacental transfer of vancomycin and telavancin.
abstract: OBJECTIVE
  We sought to determine the bidirectional transfer and distribution of vancomycin and telavancin across the dually perfused term human placental lobule.
  
  
  METHODS
  The technique of dually perfused placental lobule was used in its recirculating mode to determine the maternal to fetal (M→F) (n = 20) and fetal to maternal (n = 18) transfer of each antibiotic, which were coperfused with their radioactive isotopes. The concentrations of drugs were determined by liquid scintillation spectrometry.
  
  
  RESULTS
  In the M→F direction, the transfer of vancomycin (9.6 ± 4%) and telavancin (6.5 ± 2%) were low; however, telavancin retention by the perfused lobule was greater than that of vancomycin (P < .01). The normalized transplacental transfer of telavancin across the placental lobule in the fetal to maternal direction was higher than in the M→F direction (P < .01), suggesting the involvement of placental efflux transporters.
  
  
  CONCLUSIONS
  The ex vivo perfusion experiments revealed low transfer of vancomycin and telavancin to the fetal circuit.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Nanovskaya
authors.forename: Svetlana
authors.initials: S
authors.lastname: Patrikeeva
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhan
authors.forename: Valentina
authors.initials: V
authors.lastname: Fokina
authors.forename: Gary D V
authors.initials: GD
authors.lastname: Hankins
authors.forename: Mahmoud S
authors.initials: MS
authors.lastname: Ahmed
mesh_terms: D000617:Aminoglycosides / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D000077427:Lipoglycopeptides; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D014640:Vancomycin / Q000493:pharmacokinetics*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; D014640:Vancomycin; C487637:telavancin