title: Presentation of opsoclonus myoclonus ataxia syndrome with glutamic acid decarboxylase antibodies.
abstract: In this rare case, the patient presented with opsoclonus, myoclonus and ataxia. Serological and imaging studies revealed high glutamic acid decarboxylase antibody (GAD-Ab) levels. High-dose corticosteroids were of no benefit and subsequent intravenous immunoglobulin (IVIg) administration proved resolution of the condition. Levetiracetam proved useful in symptomatically controlling the myoclonus. Follow-up GAD-Ab levels were within normal limits.
authors.affiliation: Department of Neurology, UT Southwestern Med Ctr, Austin, Texas, USA. hbhand@mednet.swmed.edu
authors.forename: Hanul Srinivas
authors.initials: HS
authors.lastname: Bhandari
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy; D001259:Ataxia / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D003937:Diagnosis, Differential; D004433:Earache / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006261:Headache / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D053609:Lethargy / Q000276:immunology; D000077287:Levetiracetam; D008590:Meningoencephalitis / Q000175:diagnosis; D053578:Opsoclonus-Myoclonus Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D000077287:Levetiracetam; D005968:Glutamate Decarboxylase; D010889:Piracetam