title: Isolation of some luteolin derivatives from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potencies.
abstract: This study was designed to evaluate the mutagenic and antimutagenic activities of luteolin derivatives (luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds. subsp. longifolia by using Ames Salmonella test (TA 1535 and TA1537 strains). In the antimutagenicity assays, luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and TA1535 strains. The highest inhibition rates for luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.77%, respectively. Similarly, in the antimutagenicity assays performed with the TA1535 strain, the inhibition rates for luteolin 7-O-glucoside and luteolin 7-O-rutinoside were 23.86% and 23.76% respectively. Our findings showed that the antimutagenic properties of luteolin derivatives on TA1537 and TA1535 strains have been found to be structure dependent. The clarification of differences in antimutagenic potency of these luteolin derivatives based on their structures has been demonstrated in this study.
authors.affiliation: Ataturk University, Faculty of Science, Biology Department, TR-25240 Erzurum, Turkey.
authors.forename: Furkan
authors.initials: F
authors.lastname: Orhan
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Barış
authors.forename: Derya
authors.initials: D
authors.lastname: Yanmış
authors.forename: Tuğba
authors.initials: T
authors.lastname: Bal
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Güvenalp
authors.forename: Medine
authors.initials: M
authors.lastname: Güllüce
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027541:Mentha / Q000737:chemistry*; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012475:Salmonella / Q000187:drug effects / Q000235:genetics
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D047311:Luteolin