title: Novel mechanisms of EBV-induced oncogenesis.
abstract: Epstein-Barr virus is an etiologic factor in multiple types of cancer that primarily develop in lymphocytes and epithelial cells. The tumors are latently infected yet express distinct subsets of viral proteins that are essential for transformation. The viral oncogenes may be expressed in a subset of cells and are transferred through exosomes to many cells to induce growth and alter the tumor environment. In some of the viral cancers, viral proteins are not expressed, however, the viral miRNAs can alter growth by decreasing expression of negative regulators of cell growth such as tumor suppressors and cellular proteins that induce apoptosis.
authors.affiliation: Sarah Graham Kenan Distinguished Professor, Department of Microbiology & Immunology, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7295, USA. nrt@med.unc.edu
authors.forename: Nancy
authors.initials: N
authors.lastname: Raab-Traub
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002472:Cell Transformation, Viral; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins