title: Antibody levels to hantavirus in inhabitants of western Santa Catarina State, Brazil.
abstract: Hantavirus cardiopulmonary syndrome (HCPS) is an infectious disease caused by hantaviruses of the family Bunyaviridae, and is transmitted by aerosols of excreta of infected rodents. The aim of the present study was to determine antibody levels to hantavirus in the population that lives at frontier of Brazil and Argentina. Participated of the study 405 individuals living in the municipalities of Bandeirante, Santa Helena, Princesa and Tunapolis, state of Santa Catarina, Brazil. IgG antibodies to hantavirus were analyzed in sera by an ELISA that uses a recombinant N protein of Araraquara hantavirus as antigen. The results were also confirmed by immunofluorescent test. Eight individuals showed antibodies to hantavirus (1.97% positivity), with serum titers ranging from 100 to 800. Six seropositives were males, older than 30 years and farmers. Our results reinforce previous data on hantavirus circulation and human infections in the southern border of Brazil with Argentina.
authors.affiliation: Virology Research Center, School of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. wmarciel@hotmail.com
authors.forename: William Marciel de
authors.initials: WM
authors.lastname: Souza
authors.forename: Alex Martins
authors.initials: AM
authors.lastname: Machado
authors.forename: Geonildo Rodrigo
authors.initials: GR
authors.lastname: Disner
authors.forename: Everton
authors.initials: E
authors.lastname: Boff
authors.forename: Aline Rafaela da Silva Rodrigues
authors.initials: AR
authors.lastname: Machado
authors.forename: Michelly de
authors.initials: Md
authors.lastname: Padua
authors.forename: Luiz Tadeu Moraes
authors.initials: LT
authors.lastname: Figueiredo
authors.forename: Gustavo Borba de
authors.initials: GB
authors.lastname: Miranda
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D006476:Orthohantavirus / Q000276:immunology*; D018778:Hantavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G