title: Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities.
abstract: OBJECTIVE
  The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM).
  
  
  METHODS
  LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 ± 12 years) and volunteers (n = 20, age = 51 ± 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics.
  
  
  RESULTS
  Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P ≤ 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion.
  
  
  CONCLUSIONS
  Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome.
authors.affiliation: Heart Center Freiburg University, Cardiology and Angiology I, Albert-Ludwigs-University Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany. daniela.foell@uniklinik-freiburg.de
authors.forename: D
authors.initials: D
authors.lastname: Foell
authors.forename: B
authors.initials: B
authors.lastname: Jung
authors.forename: E
authors.initials: E
authors.lastname: Germann
authors.forename: F
authors.initials: F
authors.lastname: Staehle
authors.forename: C
authors.initials: C
authors.lastname: Bode
authors.forename: M
authors.initials: M
authors.lastname: Markl
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000175:diagnosis*; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D010363:Pattern Recognition, Automated; D012016:Reference Values; D018570:Risk Assessment; D012399:Rotation; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index