title: Dopamine enhances model-based over model-free choice behavior.
abstract: Decision making is often considered to arise out of contributions from a model-free habitual system and a model-based goal-directed system. Here, we investigated the effect of a dopamine manipulation on the degree to which either system contributes to instrumental behavior in a two-stage Markov decision task, which has been shown to discriminate model-free from model-based control. We found increased dopamine levels promote model-based over model-free choice.
authors.affiliation: Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK. kwunder@gmail.com
authors.forename: Klaus
authors.initials: K
authors.lastname: Wunderlich
authors.forename: Peter
authors.initials: P
authors.lastname: Smittenaar
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dolan
mesh_terms: D001545:Benserazide / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002755:Choice Behavior / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008390:Markov Chains; D008959:Models, Neurological; D008962:Models, Theoretical; D055815:Young Adult
chemical_list: D015259:Dopamine Agents; D001545:Benserazide; D004298:Dopamine