title: Cerebral vasculitis and Cardiobacterium valvarum endocarditis.
abstract: We present a case of aortic and tricuspid native valve endocarditis in which Cardiobacterium valvarum was isolated from the blood culture of a 65-year-old man. Cardiobacterium valvarum is a fastidious, Gram-negative bacillus. The genus Cardiobacterium encompasses two species - Cardiobacterium valvarum and Cardiobacterium hominis. Although both species rarely feature as the aetiological agent of endocarditis, Cardiobacterium hominis has a higher incidence than Cardiobacterium valvarum. For this causative organism, we believe this is the first report of fatality prior to surgical intervention and the first clinical course to be complicated by cerebral vasculitis. Native valve endocarditis caused by Gram-negative bacilli is extremely rare and identification of isolates may require the use of reference laboratories with molecular identification techniques.
authors.affiliation: Department of Endocrinology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: R
authors.initials: R
authors.lastname: Abraham
authors.affiliation: Department of Cardiology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: R B
authors.initials: RB
authors.lastname: Irwin
authors.affiliation: Department of Endocrinology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: D
authors.initials: D
authors.lastname: Kannappan
authors.affiliation: Department of Microbiology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: B
authors.initials: B
authors.lastname: Isalska
authors.affiliation: Department of Endocrinology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: M
authors.initials: M
authors.lastname: Koroma
authors.affiliation: Department of Endocrinology, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
authors.forename: N
authors.initials: N
authors.lastname: Younis
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D044066:Cardiobacterium / Q000302:isolation & purification*; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D012336:RNA, Ribosomal, 16S / Q000235:genetics / Q000378:metabolism; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000382:microbiology* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S