title: Effect of overweight and obesity on the left ventricular systolic and diastolic functions in patients with acute myocardial infarction.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether a association exits among overweight and obesity and left ventricular systolic and diastolic functions in patients admitted with first ST-elevation myocardial infarction (STEMI).
  
  
  METHODS
  The present study was performed on 451 consecutive patients diagnosed with first STEMI (376 men, 75 women; mean age 56.1 ± 10.8 years). The patients were classified into three groups based on their body mass index (BMI) as normal weight (BMI < 25 kg/m2), overweight (BMI: 25-29.9 kg/m2) and obese (BMI > 30 kg/m2). Echocardiographic features were evaluated and compared among the three groups.
  
  
  RESULTS
  Mitral annulus E velocities were higher in obese individuals than normal weight group (p < 0.01). In contrast, mitral A velocities were lower (p =0.03); consequently, E\A and E'\A' ratios were lower (both p = 0.01) in the obese group with respect to normal weight group. When the correction of entire variations existing among the groups were performed using multivariate linear regressions analyses, it turned out that BMI was independently associated with E/A (β = -0.19, p = 0.044) and with E'/A' (β = -0.016, p = 0.021). Ejection fraction, wall motion score index and myocardial S velocities were comparable among the study groups (p > 0.05).
  
  
  CONCLUSIONS
  These results suggest that while obesity has no adverse effect on the left ventricular systolic function, it has unfavorable consequences on the left ventricular diastolic function in the patients with first STEMI. In contrast, no unfavorable effects of overweight on the left ventricular systolic and diastolic function were detected.
authors.affiliation: Department of Cardiology, Gazi University School of Medicine, Ankara, Turkey. fpoyraz78@gmail.com
authors.forename: Fatih
authors.initials: F
authors.lastname: Poyraz
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Sinan A
authors.initials: SA
authors.lastname: Kocaman
authors.forename: Huseyin U
authors.initials: HU
authors.lastname: Yazici
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
authors.forename: Murat
authors.initials: M
authors.lastname: Tulmac
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Nazif
authors.initials: N
authors.lastname: Aygül
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Aydar
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tavil
authors.forename: Adnan
authors.initials: A
authors.lastname: Abaci
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology*; D013318:Stroke Volume; D016277:Ventricular Function, Left