title: A concise synthesis of (+)-artemisinin.
abstract: Malaria represents one of the most medically and economically debilitating diseases present in the world today. Fortunately, there exists a highly effective treatment based on the natural product artemisinin. Despite the development of several synthetic approaches to the natural product, a streamlined synthesis that utilizes low-cost chemical inputs has yet to materialize. Here we report an efficient, cost-effective approach to artemisinin. Key to the success of the strategy was the development of mild, complexity-building reaction cascades that allowed the use of readily available, affordable cyclohexenone as the key starting material.
authors.affiliation: Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
authors.forename: Chunyin
authors.initials: C
authors.lastname: Zhu
authors.forename: Silas P
authors.initials: SP
authors.lastname: Cook
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D031172:Artemisia annua / Q000737:chemistry*; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin