title: Outcome of venom bradykinin potentiating factor on rennin-angiotensin system in irradiated rats.
abstract: OBJECTIVE
  The objective of this work was to compare the effect of a bradykinin potentiating (BPF) isolated from venom of Egyptian scorpion Androctonus amoreuxi as a natural angiotensin converting enzyme inhibitor (ACEI) with losartan (LOS), a chemical angiotensin receptor blocker (ARB), in the modulation of radiation-induced damage.
  
  
  METHODS
  Rats were grouped into: (i)
  
  
  METHODS
  untreated; (ii) + C(BPF): Received intraperitoneally (i.p.) BPF 1 μg/g body weight (b.w.) (twice/week) during 3 weeks; (iii) + C(LOS:) Received i.p. LOS 5 μg/g b.w. (twice/week) during 3 weeks; (iv) R: Irradiated at 4 Gy; (v) R + BPF and (vi) R + LOS: Received BPF or LOS post-irradiation for 3 weeks.
  
  
  RESULTS
  BPF or LOS treatment induced a significant drop of sodium and uric acid. Irradiation induced a significant elevation of malondialdehyde (MDA) and advanced oxidation protein product (AOPP) associated with a significant decrease of glutathione (GSH) content in the kidney. Serum aldosterone, sodium, urea and creatinine levels showed a significant increase while a significant drop was recorded for haematological values, calcium and uric acid levels. Treatment of irradiated animals with BPF or LOS significantly improved radiation-induced changes.
  
  
  CONCLUSIONS
  It could be concluded that the use of BPF as a natural product is comparable to the chemical compound LOS.
authors.affiliation: Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Cairo, Egypt. Omaimashry@yahoo.com
authors.forename: Omaima
authors.initials: O
authors.lastname: Ashry
authors.forename: Mohamed
authors.initials: M
authors.lastname: Moustafa
authors.forename: Ahmed Abd El
authors.initials: AA
authors.lastname: Baset
authors.forename: Gamal E
authors.initials: GE
authors.lastname: Abu Sinna
authors.forename: Hesham
authors.initials: H
authors.lastname: Farouk
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D000818:Animals; D003435:Crotalid Venoms / Q000008:administration & dosage*; D019808:Losartan / Q000008:administration & dosage*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003435:Crotalid Venoms; D009842:Oligopeptides; D011837:Radiation-Protective Agents; C006791:bradykinin potentiating factors; D019808:Losartan