title: [Pathophysiological characteristics of rat pulmonary hypertension and cor pulmonale induced by monocrotaline].
abstract: OBJECTIVE
  To explore the mechanism of pulmonary hypertension and Cor Pulmonale rat models induced by monocrotaline (MCT).
  
  
  METHODS
  Twenty Wistar male rats were randomly divided into normal control group and model group (n= 10), which received a single intraperitoneal injection of MCT solution (50 mg/kg , the first day) or dissolvant, respectively. On day 28 after MCT administration, the hemodynamic parameters were assessed; levels of tumour necrosis factor-alpha (TNF-alpha), nitric oxide (NO), endothelin-1 (ET-1), B-type natriuretic peptide(BNP) in pulmonary tissue or blood were measured using radio immunoassay or nitrate reductase method.
  
  
  RESULTS
  28 days after MCT injection, compared with control group, right ventricle systolic pressure (RVSP) increased and heart rate(HR), mean arterial pressure (MAP) decreased; Levels of TNF-alpha, NO, ET-1 in pulmonary tissue or blood increased significantly in MCT group.
  
  
  CONCLUSIONS
  The potential mechanism of MCI- induced pulmonary hypertension and Cor Pulmonale rat models associates with increasing TNF-alpha, NO, ET-1 levels in vivo, which results from inflammatory injury of lung tissue and blood vessels induced by MCT.
authors.affiliation: Cardiovascular Drug Research Center, Institute of Health and Envimnental Medicine, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Jun-shan
authors.initials: JS
authors.lastname: Li
authors.forename: Chao-liang
authors.initials: CL
authors.lastname: Lng
authors.forename: Wen-yu
authors.initials: WY
authors.lastname: Cui
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000378:metabolism; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D008168:Lung / Q000378:metabolism; D008297:Male; D016686:Monocrotaline / Q000009:adverse effects*; D009569:Nitric Oxide / Q000378:metabolism; D011660:Pulmonary Heart Disease / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D016686:Monocrotaline