title: Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010.
abstract: To study epidemiological features and genetic characteristics of noroviruses in children and adults with acute gastroenteritis, fecal specimens were collected in three hospitals from Jan. 2007 to May 2010 in Wuhan, China. Noroviruses were detected in 25.9 % (286/1103) and 24.6 % (202/822) of the specimens from children and adults, respectively, with genogroup II (GII) being predominant (99.2 %). The most frequent genotype among GII strains was GII.4 (2006b variant) (77.3 %) (72.0 % in children and 87.9 % in adults), followed by GII.3 (15.0 %) and GII.6 (3.4 %). Potential recombinant genotypes (polymerase/capsid) were detected in 51 GII strains (15.9 %), including the most frequent type, GII.12/GII.3 (28 strains), and GII.16/GII.2, detected for the first time in China, which were found in only children. The results indicated that genetically similar noroviruses were circulating among children and adults as a cause of gastroenteritis, except for some recombinant genotypes.
authors.affiliation: Virology Section, Wuhan Centers for Disease Prevention and Control, Wuhan 430015, Hubei, People's Republic of China. wyhhyc@yahoo.com.cn
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Dun-Jin
authors.initials: DJ
authors.lastname: Zhou
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.forename: Souvik
authors.initials: S
authors.lastname: Ghosh
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Pang
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Peng
authors.forename: Man-Qing
authors.initials: MQ
authors.lastname: Liu
authors.forename: Quan
authors.initials: Q
authors.lastname: Hu
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Kobayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D014644:Genetic Variation; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny; D015995:Prevalence; D016865:Reassortant Viruses; D055815:Young Adult