title: [IgA nephropathy: histological analysis and clinicomorfological correlation in patients from Minas Gerais State].
abstract: BACKGROUND
  IgA nephropathy (IgAN) is the most common primary glomerulopathy.
  
  
  OBJECTIVE
  Classify IgAN according to the new Oxford's classification.
  
  
  METHODS
  We analyzed the renal biopsies from the Nephropathology Service of UFTM, among 1996 to 2010, with a diagnosis of IgAN. We assessed gender, age, presence of hematuria, patterns/intensity of the lesions, deposition of IgA, IgG, IgM, Kappa, Lambda, C3, C1q and fibrinogen. Based on the histological alterations, the biopsies were characterized according to the Oxford Classification, and the clinicomorfological correlation was made. Significative results for p < 0,05.
  
  
  RESULTS
  A total of 164 cases biopsies, predominantly male (53.7%) and adults (93.3%). We characterized the patients according Oxford Classification, there was a predominance of the pattern M0 (85,3%), S1 (53,1%), E0 (65,2%) e T0 (70,1%). About the clinicomorfological correlation, we observed more severe proteinuria comparing M1 to M0 (p < 0,008), low estimated GFR (p < 0,001) and more frequent hypertension (p < 0,001) comparing T0, T1 e T2. On immunofluorescence, there is a predominance of IgA (100% of cases), with co-deposition of C3 (99.37% of cases), Kappa (96.25%), Lambda (91.25%) and IgM (76.92%). Correlation was found between IgA intensity and C3, Kappa and Lambda.
  
  
  CONCLUSIONS
  In this study, IgA nephropathy was predominant in males, the more frequent patterns were the M0, S1, E0 and T0, with more severe proteinuria and the enhance of mesangial hypercellularity, besides larger prevalence of hypertension/worse kidney function according the tubulo-interstitial injuries.
authors.affiliation: Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
authors.forename: Precil Diego Miranda de Menezes
authors.initials: PD
authors.lastname: Neves
authors.forename: Juliana Reis
authors.initials: JR
authors.lastname: Machado
authors.forename: Marcos Vinícius da
authors.initials: MV
authors.lastname: Silva
authors.forename: Débora Tavares de Resende e Silva
authors.initials: DT
authors.lastname: Abate
authors.forename: Denise Bertulucci Rocha
authors.initials: DB
authors.lastname: Rodrigues
authors.forename: Ana Carolina Guimarães
authors.initials: AC
authors.lastname: Faleiros
authors.forename: Marlene Antônia dos
authors.initials: MA
authors.lastname: Reis
mesh_terms: D000328:Adult; D001938:Brazil; D005260:Female; D005922:Glomerulonephritis, IGA / Q000145:classification* / Q000473:pathology*; D006801:Humans; D008297:Male