title: [Correlation analysis of aspirin resistance and cycloxygenase-1 haplotype in old Chinese patients with cardio-cerebrovascular diseases].
abstract: OBJECTIVE
  To investigate whether cyclooxygenase-1 (COX-1) haplotype is associated, with aspirin resistance.
  
  
  METHODS
  The participants were 431 old Chinese Han patients with cardiovascular and cerebrovascular diseases who took aspirin. The 59 patients with aspirin resistance (AR) by light transmittance aggregation acted as the cases; the 372 aspirin-sensitive patients were the controls. The relationships between AR and 6 single nucleotide polymorphisms (SNPs) in COX-1 gene. rs1888943 (8759C/T), rs1330344 (1676A/G), rs3842787 (exon2, 50C/T, p.Pro17Leu), rs5787 (exon 4, 323G/A, p. ARg108Gln), rs5789 (exon7, 709C/A, p. Leu237Met) and rs5794 (exonl0, 1330G/A, p.Va1481Ile) were investigated by the USA Sequenom high-throughput single nucleotide polymorphisms (SNP) genotyping systems.
  
  
  RESULTS
  In this case-control trial, the frequency of mutant CGCGCC-haplotype in case was 0.48 (57/118) and in control was 0.39 (286/742), which was significantly higher than that of the control group (P < or = 0.05).
  
  
  CONCLUSIONS
  COX-1 haplotype is associated with aspirin resistance in old Chinese Han patients with cardio-cerebrovascular diseases, mutant CGCGCC-haplotype carriers of COX-1 has a significant significantly increased risk of AR.
authors.affiliation: The First Department of Geriatric Cardiology of PLA General Hospital, Beijing, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Chun-ping
authors.initials: CP
authors.lastname: Cui
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Feng-chun
authors.initials: FC
authors.lastname: Zhou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D001241:Aspirin / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000235:genetics*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000235:genetics*; D051545:Cyclooxygenase 1 / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin