title: The Clinical Meaning of Benign Colon Uptake in (18)F-FDG PET: Comparison with Colonoscopic Findings.
abstract: OBJECTIVE
  Benign colon (18)F-fluorodeoxyglucose (FDG) uptake is frequently observed in asymptomatic individuals. Aims of this study were to investigate the benign colon uptake by whole body FDG-positron emission tomography (PET) in asymptomatic adults and to correlate those results with colonoscopic and histologic findings.
  
  
  METHODS
  Among 3,540 subjects who had undergone FDG-PET, 43 subjects who were diagnosed to have benign colon uptake in FDG-PET and underwent colonoscopy were retrospectively reviewed. Subjects were classified as diffuse or focal groups based on their FDG uptake patterns. PET results were analyzed together with colonoscopic and histologic findings.
  
  
  RESULTS
  Forty-three subjects showed benign colon uptake in FDG-PET; 28 of them were shown as the diffuse group, while other 15 subjects were classified as the focal group. Five subjects among those showed diffuse uptake were diagnosed as adenoma. Seven among 15 subjects who showed focal uptake were diagnosed as adenocarcinoma (n=2), adenoma (n=3), or non-neoplastic polyp (n=2). Positive predictive values were 25% in the diffuse group and 47% in the focal group.
  
  
  CONCLUSIONS
  We recommend that patients showing benign FDG uptake in the colon should be further evaluated by colonoscopy, especially for patients with focal FDG uptake.
authors.affiliation: Department of Internal Medicine, Ewha Medical Reseach Institute and Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Roh
authors.forename: Sung-Ae
authors.initials: SA
authors.lastname: Jung
authors.forename: Seong-Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Hye-In
authors.initials: HI
authors.lastname: Kim
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Lee
authors.forename: Chung Hyun
authors.initials: CH
authors.lastname: Tae
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Ki-Nam
authors.initials: KN
authors.lastname: Shim
authors.forename: Hye-Kyung
authors.initials: HK
authors.lastname: Jung
authors.forename: Tae Hun
authors.initials: TH
authors.lastname: Kim
authors.forename: Kwon
authors.initials: K
authors.lastname: Yoo
authors.forename: Il Hwan
authors.initials: IH
authors.lastname: Moon
authors.forename: Bom Sahn
authors.initials: BS
authors.lastname: Kim