title: A systematic review of resting-state functional-MRI studies in major depression.
abstract: BACKGROUND
  To evaluate the literature pertaining to the use of resting-state functional magnetic resonance imaging (fMRI) in Major Depression (MD).
  
  
  METHODS
  A search for papers published in English was conducted using MedLine, Embase, PsycINFO, OvidSP, and ScienceDirect with the following words: resting state, depression, MRI, affective, and default-mode.
  
  
  RESULTS
  The findings from 16 resting-state fMRI studies on MD are tabulated. Some common findings are discussed in further detail.
  
  
  CONCLUSIONS
  The use of resting-state fMRI in MD research has yielded a number of significant findings that provide the basis for understanding the pathophysiology of depressive symptoms. Of particular note and deserving of further research are the roles of the cortico-limbic mood regulating circuit (MRC) and the interaction between task-positive and task-negative networks in MD. There is increasing interest in the use of resting-state fMRI in the study of psychiatric conditions, and continued improvement in technique and methodology will prove valuable in future research.
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, 94 Mallet Street, Camperdown, NSW 2050, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: D F
authors.initials: DF
authors.lastname: Hermens
authors.forename: I B
authors.initials: IB
authors.lastname: Hickie
authors.forename: J
authors.initials: J
authors.lastname: Lagopoulos
mesh_terms: D000339:Affect; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002421:Caudate Nucleus / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003863:Depression; D003865:Major Depressive Disorder / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019964:Mood Disorders / Q000473:pathology; D009415:Nerve Net / Q000503:physiopathology; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology