title: Prevalence and associated factors of diabetes and impaired fasting glucose in Chinese hypertensive adults aged 45 to 75 years.
abstract: OBJECTIVE
  This study examined the prevalence of impaired fasting glucose (IFG) and diabetes and their associated factors in 17,184 Chinese hypertensive adults aged 45-75 years.
  
  
  METHODS
  A cross-sectional investigation was carried out in a rural area of Lianyungang, China. Previously undiagnosed diabetes [fasting plasma glucose (FPG) ≥ 7.0 mmol/l] and IFG (6.1-6.9 mmol/l) were defined based on FPG concentration. Previously diagnosed diabetes was determined on the basis of self-report. Total diabetes included both previously diagnosed diabetes and previously undiagnosed diabetes.
  
  
  RESULTS
  The prevalence of previously diagnosed diabetes, undiagnosed diabetes, and IFG were 3.4%, 9.8%, and 14.1%, respectively. About 74.2% of the participants with diabetes had not previously been diagnosed. In the multivariable logistic-regression model, older age, men, antihypertensive treatment, obesity (BMI ≥ 25 kg/m(2)), abdominal obesity (waist circumference ≥ 90 cm for men and ≥ 80 cm for women), non-current smoking, a family history of diabetes, higher heart rate, lower physical activity levels, and inland residence (versus coastal) were significantly associated with both total diabetes and previously undiagnosed diabetes. Furthermore, methylene- tetrahydrofolate reductase (MTHFR) 677 TT genotype was an independent associated factor for total diabetes, and current alcohol drinking was an independent associated factor for previously undiagnosed diabetes. At the same time, older age, men, abdominal obesity, non-current smoking, current alcohol drinking, a family history of diabetes, higher heart rate, and inland residence (versus coastal) were important independent associated factors for IFG.
  
  
  CONCLUSIONS
  In conclusion, we found a high prevalence of diabetes in Chinese hypertensive adults. Furthermore, about three out of every four diabetic adults were undiagnosed. Our results suggest that population-level measures aimed at the prevention, identification (even if only based on the FPG evaluation), and treatment of diabetes should be urgently taken to overcome the diabetes epidemic in Chinese hypertensive adults.
authors.affiliation: Institute for Biomedicine, Anhui Medical University, Hefei, China.
authors.forename: Xianhui
authors.initials: X
authors.lastname: Qin
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Fangfang
authors.initials: F
authors.lastname: Fan
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.forename: Houxun
authors.initials: H
authors.lastname: Xing
authors.forename: Genfu
authors.initials: G
authors.lastname: Tang
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
mesh_terms: D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology*; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose