title: [Changes of the state of rat kidneys under guerin carcinoma development and use of cytostatics].
abstract: It was shown that development of the Guerin carcinoma and introduction of cisplatin led to the damage of the kidneys of rats that was confirmed by a relative increase of weight, proteinuria, change of gamma-glutamyl transpeptidase and lactate dehydrogenase activity in the urea and tissue homogenates of the kidneys, by a decrease of relative reabsorption and glomerular filtration. Introduction of nanoliposomal forms of the rhenium cluster compounds led to normalization of above mentioned diagnostic indexes and to reduction of the toxic cisplatin influence that was confirmed by biochemical and morphological investigations.
authors.forename: S O
authors.initials: SO
authors.lastname: Babiĭ
authors.forename: T O
authors.initials: TO
authors.lastname: Loskutova
authors.forename: N I
authors.initials: NI
authors.lastname: Shtemenko
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000652:urine*; D002945:Cisplatin / Q000009:adverse effects; D054697:Cytostatic Agents / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney; D007680:Kidney Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000652:urine*; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008081:Liposomes / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds / Q000627:therapeutic use*; D011507:Proteinuria / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D054697:Cytostatic Agents; D008081:Liposomes; D009942:Organometallic Compounds; D012211:Rhenium; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D002945:Cisplatin