title: Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs.
abstract: Here, we aim to evaluate Gelucire 44/14 as non-ionic surface-active excipient to produce immediate-release solid dosage forms for poorly water-soluble drugs. Gelucires are polyethylene glycol (PEG) glycerides composed of mono-, di- and triglycerides and mono- and diesters of PEG. They are inert semi-solid waxy amphiphilic excipients with surface-active properties that spontaneously form a fine dispersion or emulsion upon contact with water. Monolithic Gelucire 44/14 structures are prone to prolonged erosion times, thereby slowing down drug dissolution. To overcome this issue, we combine either granulation or spray-drying, followed by compression into tablets, with an optimized composition of disintegration promoting agents. This formulation strategy allows obtaining nearly 100% drug release within 10 min dissolution time.
authors.affiliation: Department of Pharmaceutics, Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
authors.forename: André B
authors.initials: AB
authors.lastname: da Fonseca Antunes
authors.forename: Bruno G
authors.initials: BG
authors.lastname: De Geest
authors.forename: Chris
authors.initials: C
authors.lastname: Vervaet
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Remon
mesh_terms: D000927:Anticonvulsants / Q000737:chemistry*; D002220:Carbamazepine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility
chemical_list: D000927:Anticonvulsants; D004337:Drug Carriers; D005079:Excipients; C104509:gelucire 44-14; D002220:Carbamazepine; D011092:Polyethylene Glycols