title: Newly developed mouse newborn behavioral testing method for evaluating the risk of neurotoxicity of environmental toxicants.
abstract: Although there have been a vast number of behavioral toxicology studies carried out on adult mice and rats, there have been few neurobehavioral studies utilizing their newborn animals. Thus, we developed a mouse newborn behavioral testing method for evaluating the risk of neurotoxicity of chemicals, by means of determining the newborn's activity using the tare function of an analytical balance. The unstable weighing values resulting from movement of the newborn on the balance recorded by a personal computer every 0.1 s, and the total activities of a newborn from the start time of weighing to individual times of evaluation were calculated. In addition, we confirmed the usefulness of our method by determining the activity of mouse newborns with microcephaly induced by prenatal exposure to a neurotoxicant, methylnitrosourea.
authors.affiliation: Laboratory of Developmental Biology, Department of Life Science, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Nagao
authors.forename: Nao
authors.initials: N
authors.lastname: Kagawa
authors.forename: Munekazu
authors.initials: M
authors.lastname: Komada
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D054750:Ecotoxicology / Q000379:methods*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D008297:Male; D018811:Maternal Exposure; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000523:psychology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000523:psychology*; D012306:Risk
chemical_list: D004785:Environmental Pollutants; D008770:Methylnitrosourea