title: Classifying collective cancer cell invasion.
abstract: Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.
authors.affiliation: Department of Cell Biology, NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Friedl
authors.forename: Joseph
authors.initials: J
authors.lastname: Locker
authors.forename: Erik
authors.initials: E
authors.lastname: Sahai
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Segall
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*