title: Reductive cleavage of 2,2,2-trichloroethyl esters by titanocene catalysis.
abstract: Esters are of widespread use for protecting carboxylic acids in organic synthesis. However, methods to cleave esters often employ harsh conditions. Herein, we report a new and mild method for the reductive cleavage of 2,2,2-trichloroethylesters (TCE esters). Our radical method employs  Cp(2)TiCl as an electron transfer catalyst and Zn dust as stoichiometric reducing agent. It avoids the use of strong Brønstedt-acids as well as aqueous conditions and can be carried out at room temperature.
authors.affiliation: University of Bonn, Department of Organic Chemistry, Gerhard Domagk Straße 1, DE-53121 Bonn, Switzerland. andreas.gansaeuer@uni-bonn.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Gansäuer
authors.forename: Tobias
authors.initials: T
authors.lastname: Dahmen
mesh_terms: D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D014241:Trichloroethylene / Q000031:analogs & derivatives* / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D001565:Benzoates; D005609:Free Radicals; D009942:Organometallic Compounds; C406884:titanocene; D014241:Trichloroethylene; D015032:Zinc