title: Norbornene-derived poly-D-lysine copolymers as quantum dot carriers for neuron growth.
abstract: Synthesis of norbornene derived phosphonate (1), poly-D-lysine (2), and phopholipid (3) monomers and their complete characterizations are studied. Ring-opening metathesis polymerizations (ROMP) of monomers (1-3) produce well-defined copolymers, CP(1) and CP(2). (1)H NMR along with FT-IR spectroscopy characterization confirms the copolymer formation, while gel permeation chromatography (GPC) analysis suggests the formation of polymers with fairly narrow molecular weight distributions. Upon following the well-known ligand exchange methods these copolymers produce CdSe-bound copolymers, CP(3) and CP(4). Dynamic light scattering and transmission electron microscopy measures the size of these CdSe bound copolymers, while (31)P NMR suggests the formation of CP(3) and CP(4). The results from the experiments of these copolymers on Neuro2A cells suggest that the novel PDL-anchored nanomaterial show their ability to polarize neuronal growth and differentiation.
authors.affiliation: Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata (IISER K), India.
authors.forename: Vijayakameswara N
authors.initials: VN
authors.lastname: Rao
authors.forename: Abhinoy
authors.initials: A
authors.lastname: Kishore
authors.forename: Santu
authors.initials: S
authors.lastname: Sarkar
authors.forename: Jayasri
authors.initials: J
authors.lastname: Das Sarma
authors.forename: Raja
authors.initials: R
authors.lastname: Shunmugam
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D016764:Cell Polarity / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D049329:Nanostructures / Q000737:chemistry*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D009636:Norbornanes / Q000138:chemical synthesis* / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D045663:Quantum Dots; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D009636:Norbornanes; D063065:Organophosphonates; D011108:Polymers; D011107:Polylysine