title: Low abundance plasma proteins in labour.
abstract: Every year, millions of births worldwide are complicated by prematurity or difficult post-term deliveries, resulting in a high incidence of perinatal mortality and morbidity. Our poor understanding of human parturition is a key reason for our inability to improve the management of preterm and post-term birth. In this study, we used proteomic techniques to look into protein changes in placental blood plasma obtained from women before or after spontaneous or induced labour, with vaginal or caesarean section deliveries. Our aim was to understand the basic mechanisms of human parturition regardless of whether the signals that trigger labour are of maternal and/or fetal origin. We found proteins from 33 genes with significantly altered expression profiles in relation to mode of labour and delivery. Most changes in labour occurred in proteins associated with 'immune and defence responses'. Although the signal transduction and regulation of these pathways varied among modes of delivery, hepatocyte nuclear factor 1 homeobox A emerged as a shared protein in the mechanism of labour. Moreover, several apolipoproteins such as apolipoprotein A-IV and APOE were found to change with labour, and these changes were also confirmed in maternal plasma. This study has identified significant protein changes in placental intervillous plasma with labour and has revealed several pathways related to human parturition.
authors.affiliation: School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Kate
authors.initials: K
authors.lastname: Heesom
authors.forename: Robert
authors.initials: R
authors.lastname: Phillips
authors.forename: Lina
authors.initials: L
authors.lastname: Chen
authors.forename: Jo
authors.initials: J
authors.lastname: Trinder
authors.forename: Andrés
authors.initials: A
authors.lastname: López Bernal
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics; D001185:Artificial Intelligence; D015415:Biomarkers / Q000097:blood; D002585:Cesarean Section; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000097:blood / Q000235:genetics; D006801:Humans; D007751:Labor, Induced; D007743:Labor, Obstetric / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D010920:Placenta / Q000098:blood supply / Q000378:metabolism; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood* / Q000235:genetics; D040901:Proteomics / Q000379:methods; D055815:Young Adult
chemical_list: D001054:Apolipoproteins A; D001057:Apolipoproteins E; D015415:Biomarkers; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D011257:Pregnancy Proteins; C022205:apolipoprotein A-IV