title: Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones.
abstract: Flavanones, chromanones, and related structures are privileged natural products that display a wide variety of biological activities. Although flavanoids are abundant in nature, there are a limited number of available general and efficient synthetic methods for accessing molecules of this class in a stereoselective manner. Their structurally simple architectures belie the difficulties involved in installation and maintenance of the stereogenic configuration at the C2 position, which can be sensitive and can undergo epimerization under mildly acidic, basic, and thermal reaction conditions. This review presents the methods currently used to access these related structures. The synthetic methods include manipulation of the flavone/flavanone core, carbon-carbon bond formation, and carbon-heteroatom bond formation.
authors.affiliation: Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, Evanston, IL 60208, USA, ,  http://chemgroups.northwestern.edu/scheidt.
authors.forename: Antoinette E
authors.initials: AE
authors.lastname: Nibbs
authors.forename: Karl A
authors.initials: KA
authors.lastname: Scheidt