title: Human immunodeficiency virus infection and chronic myeloid leukemia.
abstract: CML (chronic myeloid leukaemia) in association with HIV (human immunodeficiency virus) infection (HIV-CML) is rarely described and is likely to be coincidental. The natural history and behaviour of HIV-CML is different, being more atypical and aggressive. Both conditions, and their respective treatments may cause myelosuppression. Concurrent treatment with cART (combination antiretroviral therapy) and the tyrosine kinase inhibitors (TKI's) can result in appropriate control of CML and HIV infection, as well as long term survival. However, drug interactions between ARV's and TKI's may require adjustment of treatment.
authors.affiliation: Division of Clinical Haematology, Department of Medicine, Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa. moosa.patel@wits.ac.za
authors.forename: Moosa
authors.initials: M
authors.lastname: Patel
authors.forename: Vinitha
authors.initials: V
authors.lastname: Philip
authors.forename: Fatima
authors.initials: F
authors.lastname: Fazel
authors.forename: Atul
authors.initials: A
authors.lastname: Lakha
authors.forename: Alexander
authors.initials: A
authors.lastname: Vorog
authors.forename: Nazeer
authors.initials: N
authors.lastname: Ali
authors.forename: Alan
authors.initials: A
authors.lastname: Karstaedt
authors.forename: Sugeshni
authors.initials: S
authors.lastname: Pather
mesh_terms: D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use
chemical_list: D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors