title: Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization.
abstract: OBJECTIVE
  To evaluate the association between men's body mass index (BMI), early embryo quality, and clinical outcomes in couples undergoing in vitro fertilization (IVF).
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Fertility clinic in an academic medical center.
  
  
  METHODS
  114 couples who underwent 172 assisted reproduction cycles.
  
  
  METHODS
  None.
  
  
  METHODS
  Fertilization rate, embryo quality, implantation rate, clinical pregnancy rate, and live birth rate.
  
  
  RESULTS
  The fertilization rate was higher among obese men than among normal weight men in conventional IVF cycles. No statistically significant associations were found between men's BMI and the proportion of poor-quality embryos on day 3, slow embryo cleavage rate, or accelerated embryo cleavage rate. Men's BMI was unrelated to positive β-human chorionic gonadotropin rate, clinical pregnancy rate, or live-birth rate per embryo transfer. Among couples undergoing intracytoplasmic sperm injection, the odds of live birth in couples with obese male partners was 84% lower than the odds in couples with men with normal BMI.
  
  
  CONCLUSIONS
  Our data suggest a possible deleterious effect of male obesity on the odds of having a live birth among couples undergoing intracytoplasmic sperm injection.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, Massachusetts 02115, USA. dcolaci@hsph.harvard.edu
authors.forename: Daniela S
authors.initials: DS
authors.lastname: Colaci
authors.forename: Myriam
authors.initials: M
authors.lastname: Afeiche
authors.forename: Audrey J
authors.initials: AJ
authors.lastname: Gaskins
authors.forename: Diane L
authors.initials: DL
authors.lastname: Wright
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Toth
authors.forename: Cigdem
authors.initials: C
authors.lastname: Tanrikut
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Chavarro
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D015992:Body Mass Index; D001900:Boston; D010064:Embryo Implantation; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007246:Infertility / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D016014:Linear Models; D050498:Live Birth; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D016017:Odds Ratio; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects; D016896:Treatment Outcome