title: A case report of placental mesenchymal dysplasia with an increased VEGF-D expression.
abstract: The pathogenesis of placental mesenchymal dysplasia (PMD) remains unclear. This report presents a case of PMD with a female fetus complicated with intrauterine growth restriction (IUGR). The ultrasound findings were similar to molar pregnancies, but PMD was suspected based on the presence of low β-hCG levels and a normal karyotype. After delivery, pathological examination of the placenta showed dilated villi and thick-walled vessels lacking trophoblast proliferation, which thus led to a diagnosis of PMD. The VEGF-D (Xp22.31) mRNA expression was found to have increased in the abnormal villi. Whether this is an incidental or X-linked gene specific event in, IUGR complicated, PMD pathogenesis warrants further investigation of VEGF-D expression in PMD.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan. itoto@med.nagoya-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: S
authors.initials: S
authors.lastname: Sumigama
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Mano
authors.forename: E
authors.initials: E
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Iwase
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: T
authors.initials: T
authors.lastname: Nagasaka
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Ino
authors.forename: F
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D014463:Ultrasonography; D042643:Vascular Endothelial Growth Factor D / Q000096:biosynthesis*
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D042643:Vascular Endothelial Growth Factor D