title: Investigation of an autologous blood treatment strategy for temporomandibular joint hypermobility in a pig model.
abstract: Many different surgical and non-surgical techniques are used for the treatment of temporomandibular joint (TMJ) hypermobility. One of these methods is autologous blood injection into the TMJ. The fate of the autologous blood used for treatment of recurring condylar dislocation is still not completely understood. The authors used 12 pigs (Sus scrota f. domestica) as a model species for autologous blood delivery into the TMJ. Blood injection was followed by histopathological analysis at different times after treatment (1h, 1, 2 and 4 weeks). Samples were examined by magnetic resonance imaging, macroscopic and histological methods. The deposition of the remaining blood was observed in the form of clots in the distal parts of the upper joint cavity 1h and 1 week after treatment. 2 weeks after treatment, small blood clots were still apparent in the distal part of the upper joint cavity. 4 weeks after surgery, no remnants of blood, changes or adhesions were apparent inside the TMJ. No morphological or histological changes were observed in the TMJ after the injection of autologous blood suggesting another mechanism is involved in the hypermobility treatment.
authors.affiliation: Institute of Animal Physiology and Genetics CAS, v.v.i., Brno, Czech Republic. stembirek@iach.cz
authors.forename: J
authors.initials: J
authors.lastname: Stembirek
authors.forename: E
authors.initials: E
authors.lastname: Matalova
authors.forename: M
authors.initials: M
authors.lastname: Buchtova
authors.forename: V
authors.initials: V
authors.lastname: Machon
authors.forename: I
authors.initials: I
authors.lastname: Misek
mesh_terms: D000818:Animals; D001769:Blood / Q000378:metabolism; D001777:Blood Coagulation; D001804:Blood Transfusion, Autologous / Q000379:methods*; D004195:Disease Models, Animal; D007270:Injections, Intra-Articular; D004204:Joint Dislocations / Q000378:metabolism / Q000628:therapy*; D008137:Longitudinal Studies; D019152:Paracentesis; D034421:Sus scrofa; D013582:Synovial Fluid / Q000378:metabolism*; D013704:Temporomandibular Joint / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000628:therapy*