title: Size at birth and insulin-like growth factor-I and its binding protein-1 among infants of diabetic mothers.
abstract: OBJECTIVE
  to estimate the association between intrauterine fetal growth, evaluated by anthropometric measurements, and biochemical growth factors; IGF-I and IGBP-1 among IDMs.
  
  
  METHODS
  Cross-sectional study carried out on 69 full term IDMs who was admitted to neonatal intensive care units, Ain Shams University Hospitals. Clinical examination including anthropometric measurements; birth weight, length, head circumference, mid-arm circumference, skinfold thickness at triceps and subscapular areas and placental weight. Laboratory investigations included maternal HbA(1c) and cord blood IGF-I and IGBP-1. They were classified into three groups: 20 small for gestational age (SGA), 25 appropriate for gestational age (AGA) and 24 large for gestational age (LGA).
  
  
  RESULTS
  Most of SGA neonates were born to mothers with type I diabetes, while most of AGA and LGA were born to mothers with gestational diabetes. According to maternal HbA(1c), SGA and LGA neonates were born to metabolically uncontrolled mothers while AGA neonates were born to well-controlled diabetic mothers. Anthropometric measurements had significant positive correlations with IGF-I and negative correlations with IGFBP-1.
  
  
  CONCLUSIONS
  Good control of diabetes during pregnancy is essential to improve fetal growth. There is an opposing effect of cord blood IGF-I and IGFBP-1 on anthropometric measurements.
authors.affiliation: Biological Anthropology Department, National Research Centre, Giza, Egypt. masrysa@yahoo.com
authors.forename: Sahar A
authors.initials: SA
authors.lastname: El-Masry
authors.forename: Mona M
authors.initials: MM
authors.lastname: El-Ganzoury
authors.forename: Rania A
authors.initials: RA
authors.lastname: El-Farrash
authors.forename: Mona
authors.initials: M
authors.lastname: Anwar
authors.forename: Rasha Z
authors.initials: RZ
authors.lastname: Abd Ellatife
mesh_terms: D000328:Adult; D001724:Birth Weight; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I