title: Magnetic resonance imaging to assess the effect of exercise training on pulmonary perfusion and blood flow in patients with pulmonary hypertension.
abstract: OBJECTIVE
  To evaluate whether careful exercise training improves pulmonary perfusion and blood flow in patients with pulmonary hypertension (PH), as assessed by magnetic resonance imaging (MR).
  
  
  METHODS
  Twenty patients with pulmonary arterial hypertension or inoperable chronic thromboembolic PH on stable medication were randomly assigned to control (n = 10) or training groups (n = 10). Training group patients received in-hospital exercise training; patients of the sedentary control group received conventional rehabilitation. Medication remained unchanged during the study period. Changes of 6-min walking distance (6MWD), MR pulmonary flow (peak velocity) and MR perfusion (pulmonary blood volume) were assessed from baseline to week 3.
  
  
  RESULTS
  After 3 weeks of training, increases in mean 6MWD (P = 0.004) and mean MR flow peak velocity (P = 0.012) were significantly greater in the training group. Training group patients had significantly improved 6MWD (P = 0.008), MR flow (peak velocity -9.7 ± 8.6 cm/s, P = 0.007) and MR perfusion (pulmonary blood volume +2.2 ± 2.7 mL/100 mL, P = 0.017), whereas the control group showed no significant changes.
  
  
  CONCLUSIONS
  The study indicates that respiratory and physical exercise may improve pulmonary perfusion in patients with PH. Measurement of MR parameters of pulmonary perfusion might be an interesting new method to assess therapy effects in PH. The results of this initial study should be confirmed in a larger study group.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. ley@gmx.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Frank
authors.initials: F
authors.lastname: Risse
authors.forename: Nicola
authors.initials: N
authors.lastname: Ehlken
authors.forename: Christine
authors.initials: C
authors.lastname: Fischer
authors.forename: Julia
authors.initials: J
authors.lastname: Ley-Zaporozhan
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.forename: Hans
authors.initials: H
authors.lastname: Klose
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Gruenig
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000534:rehabilitation*; D021621:Imaging, Three-Dimensional / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011446:Prospective Studies; D011652:Pulmonary Circulation / Q000502:physiology*; D011788:Quality of Life; D012016:Reference Values; D012138:Respiratory Therapy / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome