title: Synthesis and antimicrobial screening of N-[2-(2/4-substituted phenyl)-1-(5/6 substituted 1H- benzimidazol-2-yl)vinyl]benzamides.
abstract: A series of (benzamidostyryl)benzimidazole derivatives were synthesized by hydrolyzing 2-phenyl-4-(substituted)benzylidene-5-oxazolones, the azlactone precursors in an acidic medium and treating the product with substituted o-phenylenediamine (OPDA) in situ. The structures of the synthesized compounds were confirmed by spectral and elemental analyses. All synthesized compounds were screened for their in vito antimicrobial activities against some identifiable strains. Thereby, it was found that only nitro substituted benzimidazoles exhibited good to moderate antibacterial activity, while other derivatives were devoid of any antimicrobial effect.
authors.affiliation: Medicinal Chemistry Division, F/O Pharmacy, Jamia Hamdard, New Delhi-1 1062, India. darpkaush@yahoo.com
authors.forename: Darpan
authors.initials: D
authors.lastname: Kaushik
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: Gita
authors.initials: G
authors.lastname: Chawla
authors.forename: Bibhu P
authors.initials: BP
authors.lastname: Panda
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D052978:Disk Diffusion Antimicrobial Tests; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001549:Benzamides; D001562:Benzimidazoles