title: Expedient synthesis of norbenzomorphan library via multicomponent assembly process coupled with ring-closing reactions.
abstract: A 124-member norbenzomorphan library has been prepared utilizing a novel multicomponent assembly process (MCAP) followed by a variety of ring-closing reactions to generate norbenzomorphan scaffolds that were readily derivatized via a series of aryl halide cross-coupling and nitrogen functionalization reactions. Biological screening has revealed some novel activities that have not been previously associated with this class of compounds.
authors.affiliation: Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas , Austin, Texas 78712, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Sahn
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D001575:Benzomorphans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D055808:Drug Discovery; D006801:Humans; D009584:Nitrogen / Q000737:chemistry
chemical_list: D001575:Benzomorphans; D009584:Nitrogen