title: [The influence of autologous umbilical cord blood and donor blood on cytokine profile of newborns with transposition of great vessels].
abstract: We investigated the serum levels ofproinflammatory and antiinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10) in newborns with transposition of the great arteries to whom during the defect correction the autologous umbilical cord blood and blood components were administered before the surgery and at the 1st, 3rd, 7th day after the surgery. We found that in the group of newborns to whom during the operation the blood components were used, the levels ofpro-inflammatory interleukins were high before surgery and at the Ist, 3rd and 7th day after it, but IL-10 was reduced. During the postoperative period, the newborns of this group had imbalance in the system cytokine, accompanied by clinical complications such as hyperthermia and pulmonary complications. Newborns with transposition of the great arteries who had the surgery using the autologous cord blood, had no significant abnormalities in serum levels cytokine before the surgery. The Ist day after surgery there was an increase in both proinflammatory and antiinflammatory cytokines. Up to 7 days the levels of interleukin gradually decreased. Newborns in this group had no postoperative complications, had an adequate immune response to the operation.
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Tkachenko
authors.forename: H M
authors.initials: HM
authors.lastname: Vorobĭova
authors.forename: V A
authors.initials: VA
authors.lastname: Zhovnir
authors.forename: I M
authors.initials: IM
authors.lastname: Iemets'
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D016913:Blood Component Transfusion; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D005312:Fetal Blood; D005334:Fever / Q000097:blood* / Q000150:complications / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000276:immunology; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D016209:Interleukin-8 / Q000097:blood / Q000276:immunology; D058408:Th1-Th2 Balance; D014188:Transposition of Great Vessels / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10