title: Asymmetric Michael addition of ketones to alkylidene malonates and allylidene malonates via enamine-metal Lewis acid bifunctional catalysis.
abstract: Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.
authors.affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Ryan
authors.initials: R
authors.lastname: Sarkisian
authors.forename: Zhenghu
authors.initials: Z
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D007659:Ketones; D058116:Lewis Acids; D008314:Malonates; D019216:Metals, Heavy; D009942:Organometallic Compounds