title: Trisomy 8 in myeloid leukemia cutis confirmed by fluorescence in situ hybridization analysis.
abstract: We present a case of a 64-year-old man with refractory acute myeloid leukemia and trisomy 8 who developed leukemia cutis. Interphase fluorescence in situ hybridization (FISH) was performed on a paraffin-embedded skin section. FISH confirmed a population of cells with trisomy 8 in the blastic infiltrates involving the skin. This case illustrates a novel application of interphase FISH to confirm the diagnosis of leukemia cutis.
authors.affiliation: Department of Pathology, New York University School of Medicine, New York, NY 10016, USA. Marianna.Shvartsbeyn@nyumc.org
authors.forename: Marianna
authors.initials: M
authors.lastname: Shvartsbeyn
authors.forename: Shane M
authors.initials: SM
authors.lastname: Meehan
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Mary Lynn
authors.initials: ML
authors.lastname: Nierodzik
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Perle
mesh_terms: D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology; D014314:Trisomy / Q000235:genetics / Q000473:pathology