title: Development and characterization of self emulsifying drug delivery system of a poorly water soluble drug using natural oil.
abstract: Objective of present study involves preparation and evaluation of self emulsifying drug delivery system (SEDDS) of ibuprofen using peanut oil. SEDDS were composed of varying concentrations of peanut oil (solvent), tween 80 (surfactant) and span 20 (co-surfactant). Influence of concentration of surfactant/co-surfactant and globule size on dissolution rate was investigated. Dissolution rate was studied in phosphate buffer pH 6.8 using dissolution apparatus II. The dissolution rate of self emulsifying capsule was found to be significantly faster than that from conventional tablet. The optimized SEDDS released approximately above 85% of ibuprofen within 30 min, while conventional ibuprofen tablet could released only 36% in 30 min. Therefore, these SEDDS could be a better alternative to conventional drug delivery system of ibuprofen.
authors.affiliation: Adarsh Vijendra Institute of Pharmaceutical Sciences, Gangoh Saharanpur (U.P), India. shivani86vats@gmail.com
authors.forename: Shivani
authors.initials: S
authors.lastname: Sharma
authors.forename: Himani
authors.initials: H
authors.lastname: Bajaj
authors.forename: Piyush
authors.initials: P
authors.lastname: Bhardwaj
authors.forename: Anshul Dutt
authors.initials: AD
authors.lastname: Sharma
authors.forename: Ranjeet
authors.initials: R
authors.lastname: Singh
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D006601:Hexoses / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D010316:Particle Size; D000074241:Peanut Oil; D010938:Plant Oils / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004655:Emulsions; D006601:Hexoses; D000074241:Peanut Oil; D010938:Plant Oils; D011136:Polysorbates; D013501:Surface-Active Agents; C014822:sorbitan monolaurate; D007052:Ibuprofen