title: [Expression and potential role of metastasis-associated protein 1 in the induced carcinogenesis of mouse liver].
abstract: OBJECTIVE
  To establish a hepatocellular carcinoma model of BALB/c mouse and to study the expression and potential role of metastasis-associated protein 1 (MTA1) in the carcinogenesis process.
  
  
  METHODS
  Normal adult male BALB/c mice were induced by the combined dimethylnitrosamine (DEN)/carbon tetrachloride (CCl(4);)/alcohol for 150 d. The  morphological changes in liver cells and the expression of MTA1 in the liver lesions were observed by HE and immunohistochemical stainings, respectively.
  
  
  RESULTS
  The pathological changes of the survivals'  livers in experimental group were liver inflammation, fibrosis and cancer in sequence. The level of MTA1 increased in the carcinogenesis process, and MTA1 was mainly expressed in the cytoplasm of the cells suffering cirrhosis.
  
  
  CONCLUSIONS
  The changes of the expression sites and quantity of MTA1 in the DEN-induced carcinogenesis of mouse liver indicate that MTA1 may play an important role in the whole process of liver carcinogenesis.
authors.affiliation: No. 88 Hospital of PLA, Tai'an, China. simplebobo@foxmail.com
authors.forename: Bo
authors.initials: B
authors.lastname: Xin
authors.forename: Xue-ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Qin
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Ma
authors.forename: Ji-peng
authors.initials: JP
authors.lastname: Yin
authors.forename: Rui-an
authors.initials: RA
authors.lastname: Wang
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: C503336:Mta1 protein, mouse; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors