title: Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.
abstract: OBJECTIVE
  The aim of this study was to determine whether the ADAM33 (a disintegrin and metalloproteinase domain 33) T1 (rs2280091), T2 (rs2280090), and ST+7 (rs574174) polymorphisms confer susceptibility to asthma.
  
  
  METHODS
  A meta-analysis stratified by ethnicity and age was conducted on associations between the ADAM33 T1, T2, and ST+7 polymorphisms and asthma.
  
  
  RESULTS
  Eleven studies, which included 4,124 patients and 7,094 controls, were available for the meta-analysis. Meta-analysis revealed an association between asthma and the ADAM33 T1 GG genotype [odds ratio (OR) = 2.257, 95 % confidence interval (CI) = 1.577-3.228, p = 8.42 × 10(-7)]. Stratification by ethnicity indicated an association between this genotype and asthma in Asians (OR = 2.683, 95 % CI = 1.799-4.001, p = 1.31 × 10(-7)), and stratification by age indicated an association between it and asthma in adults (OR = 1.895, 95 % CI = 1.005-3.573, p = 0.048). However, no association was found between asthma and the ADAM33 T2 and ST+7 polymorphisms.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no association was found between the ADAM33 T2 and ST+7 polymorphisms and asthma susceptibility.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.kr
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Gwan Gyu
authors.initials: GG
authors.lastname: Song
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human