title: Association of adiponectin gene polymorphism (+T45G) with acute coronary syndrome and circulating adiponectin levels.
abstract: We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case-control study was performed in 142 Arab patients with ACS and 122 controls. Genotypes were determined using TaqMan real-time polymerase chain reaction assay. The TT, TG, and GG genotype frequencies of the T45G variant were significantly different among cases and controls (P = .023) but not significant for G276T genotypic frequencies. It was found that only the +45G allele was significantly associated with 3-fold increased risk of ACS (odds ratio = 2.77; 1.03-6.96; P = .043) among patients, using the genetic recessive model. Carriers of GG alleles had significantly lower adiponectin levels compared to TT/TG carriers of T45G in patients with ACS. The present study suggests that only T45G single-nucleotide polymorphism in the adiponectin gene is associated with higher odds for ACS events and has an effect on serum adiponectin levels among Arab populations.
authors.affiliation: Health Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar. nassrizk@qu.edu.qa
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Rizk
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Menyar
authors.forename: Isra
authors.initials: I
authors.lastname: Marei
authors.forename: Maha
authors.initials: M
authors.lastname: Sameer
authors.forename: Tasneem
authors.initials: T
authors.lastname: Musad
authors.forename: Dima
authors.initials: D
authors.lastname: Younis
authors.forename: Fathi
authors.initials: F
authors.lastname: Farag
authors.forename: Nora
authors.initials: N
authors.lastname: Basem
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Ali
authors.forename: Jassim
authors.initials: J
authors.lastname: Al Suwaidi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D052242:Adiponectin / Q000097:blood* / Q000235:genetics*; D000328:Adult; D018912:Arabs / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011780:Qatar / Q000453:epidemiology; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers