title: Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin.
abstract: A series of polymers were synthesized by cross-linking carboxyl poly(glycerol methacrylate) (PGOHMA) using hexamethylene diisocyanate (HDI). The structures and molecular weight were characterized by ¹H NMR and gel permeation chromatography (GPC). Nanoparticles were then fabricated for encapsulation of doxorubicin hydrochloride (DOX). The encapsulation and release were affected by the chemical structure and degree of cross-linking of the polymers. The polymers were quite effective in the encapsulation of DOX, and exhibited pH-dependent drug release. Specifically, the stability of nanoparticles in neutral pH was significant enhanced and the release rate was enhanced at acidic pH after cross-linking, which could be potential useful as a controlled drug release carrier, especially for anti-cancer drug.
authors.affiliation: School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.
authors.forename: Wenxing
authors.initials: W
authors.lastname: Gu
authors.forename: Yanan
authors.initials: Y
authors.lastname: Ma
authors.forename: Chuyu
authors.initials: C
authors.lastname: Zhu
authors.forename: Baoquan
authors.initials: B
authors.lastname: Chen
authors.forename: Jianbiao
authors.initials: J
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000737:chemistry; D003485:Cyanates / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D017953:Isocyanates; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D003432:Cross-Linking Reagents; D003485:Cyanates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017953:Isocyanates; D008689:Methacrylates; D011108:Polymers; C015262:1,6-hexamethylene diisocyanate; D004317:Doxorubicin