title: New Zealand Malayan war veterans' exposure to dibutylphthalate is associated with an increased incidence of cryptorchidism, hypospadias and breast cancer in their children.
abstract: It is well known that the endocrine-disrupting chemical (EDC) dibutylphthalate (DBP) inhibits testosterone synthesis and can lead to feminisation in male laboratory animals. Moreover, it has long been speculated that human exposure would result in the similar effects, but this is difficult to study because specific human exposure cohorts are rare. We report increases in the incidences of hypospadias (p<0.05), cryptorchidism (p<0.05) and breast cancer (p<0.05) in the children of New Zealand soldiers who served in Malaya (1948-1960) and were exposed to DBP applied daily to their clothing as an acaricide to prevent tick-transmitted bush typhus. In addition, we modelled absorption of DBP from the soldiers' clothing and using published data for skin absorption, and calculated a large theoretical absorbed dose of 64 mg/kg body weight/day which is similar to DBP's lowest observed adverse effect level (LOAEL) of 50 mg/kg body weight/day and thus indicates a biological effect is possible. This is the first report of a multigenerational developmental effect following DBP exposure in human males.
authors.affiliation: Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Matthew
authors.initials: M
authors.lastname: Carran
authors.forename: Ian C
authors.initials: IC
authors.lastname: Shaw
mesh_terms: D056810:Acaricides / Q000009:adverse effects* / Q000737:chemistry; D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D003020:Clothing; D003456:Cryptorchidism / Q000453:epidemiology / Q000209:etiology*; D003993:Dibutyl Phthalate / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D005831:Genital Diseases, Female / Q000453:epidemiology / Q000209:etiology; D005832:Genital Diseases, Male / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007021:Hypospadias / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D008296:Malaysia; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D018812:Paternal Exposure / Q000009:adverse effects*; D010968:Plasticizers / Q000009:adverse effects* / Q000737:chemistry; D011629:Puberty, Precocious / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012869:Skin Absorption; D014728:Veterans
chemical_list: D056810:Acaricides; D010968:Plasticizers; D003993:Dibutyl Phthalate