title: Prospective observational study of donor-site morbidity following anterior iliac crest bone-grafting in orthopaedic trauma reconstruction patients.
abstract: BACKGROUND
  Complications associated with iliac crest bone-graft donor sites have been reported. This prospective study was conducted to determine the prevalence of pain and complications at the iliac crest donor site in patients undergoing treatment of fracture nonunion.
  
  
  METHODS
  Ninety-two patients undergoing anterior iliac crest bone-grafting for nonunion or delayed union of a long-bone fracture were prospectively enrolled. Twenty-seven patients undergoing an alternative surgical treatment were enrolled as a control group. Questionnaires including pain on a visual analog scale (0 to 10) at the donor site were completed by patients at two weeks, six weeks, three months, and one year postoperatively. Short Form-36 (SF-36) forms were completed at enrollment and at the time of final follow-up.
  
  
  RESULTS
  The mean pain on the visual analog scale at the donor site was 3.9 at two weeks but rapidly decreased to 1.4 at six weeks and reached 0.3 at one year or more postoperatively (p<0.001). Only two patients (2%) reported a pain value of >3 at one year or more postoperatively. There were three deep infections (3%) at the donor site, and no patients had a permanent sensory deficit in the lateral femoral cutaneous nerve distribution. At the time of final follow-up (mean, twenty-two months), scores for the SF-36 bodily pain subscale were significantly higher in the iliac crest group than in the control group, indicating a greater improvement in overall bodily pain in the iliac crest group.
  
  
  CONCLUSIONS
  Anterior iliac crest bone-grafting for nonunion was a well-tolerated procedure. Substantial, persistent pain at the iliac crest donor site occurred in 2% of patients. Iliac crest bone-grafting did not appear to impair function or well-being compared with alternative treatments.
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Clinical Research, Carolinas Medical Center, Charlotte, North Carolina 28204, USA. bloeffler20@gmail.com
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Loeffler
authors.forename: James F
authors.initials: JF
authors.lastname: Kellam
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Sims
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bosse
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal / Q000009:adverse effects / Q000379:methods; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000601:surgery; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007085:Ilium / Q000601:surgery / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000503:physiopathology*; D011446:Prospective Studies; D011859:Radiography; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000379:methods; D018570:Risk Assessment; D060053:Transplant Donor Site / Q000503:physiopathology*; D014182:Transplantation, Autologous; D016896:Treatment Outcome