title: Eph receptors and ephrins as targets for cancer therapy.
abstract: Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling pathways and mediate critical steps of a wide variety of physiological and pathological processes. Increasing experimental evidence demonstrates that both Eph receptor and ephrin ligands are overexpressed in a number of human tumours, and are associated with tumour growth, invasiveness and metastasis. In this regard, the Eph/ephrin system provides the foundation for potentially exciting new targets for anticancer therapies for Eph-expressing tumours. The purpose of this review is to outline current advances in the role of Eph receptors and ephrin ligands in cancer, and to discuss novel therapeutic approaches of anticancer therapies.
authors.affiliation: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Hong-Qing
authors.initials: HQ
authors.lastname: Xi
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
mesh_terms: D001665:Binding Sites; D036342:Ephrins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D036081:Receptors, Eph Family / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family