title: Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis.
abstract: In the current study, a novel niosome based formulation of diallyl disulfide (DADS) was evaluated for its potential to treat disseminated candidiasis in mouse model. Among various non-ionic surfactants tested, niosome formulation prepared using Span 80 was found to be most efficient in the entrapment of DADS. The DADS loaded niosomes had size dimensions in the range of 140 ± 30 nm with zeta potential of -30.67 ± 4.5. Liver/kidney function tests as well as histopathologic studies suggested that noisome-based DADS formulations are safe at the dose investigated. When administered to Candida albicans infected animals, the DADS bearing niosomal formulation cleared the fungal burden and increased their survival much efficiently than its free form.
  
  
  BACKGROUND
  In this study, a novel niosomal formulation of the antifungal DADS was utilized in a murine candidiasis model, resulting in more efficient fungal clearance compared to the free formulation.
authors.affiliation: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
authors.forename: Maroof
authors.initials: M
authors.lastname: Alam
authors.forename: Swaleha
authors.initials: S
authors.lastname: Zubair
authors.forename: Mohammad
authors.initials: M
authors.lastname: Farazuddin
authors.forename: Ejaj
authors.initials: E
authors.lastname: Ahmad
authors.forename: Arbab
authors.initials: A
authors.lastname: Khan
authors.forename: Qamar
authors.initials: Q
authors.lastname: Zia
authors.forename: Abida
authors.initials: A
authors.lastname: Malik
authors.forename: Owais
authors.initials: O
authors.lastname: Mohammad
mesh_terms: D000498:Allyl Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy*; D004220:Disulfides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D006601:Hexoses / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D013501:Surface-Active Agents / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000498:Allyl Compounds; D000935:Antifungal Agents; D004220:Disulfides; D004337:Drug Carriers; D006601:Hexoses; D013501:Surface-Active Agents; C018665:sorbitan monooleate; C028009:diallyl disulfide