title: Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice.
abstract: OBJECTIVE
  To study the antidiabetic activity of Pleurotus ostreatus in normal and alloxan-induced diabetic mice.
  
  
  METHODS
  Ethanolic extract of fruiting bodies of P. ostreatus was tested for their antidiabetic activity. BALB/C mice (25-30 g) were divided into four groups of six animals each normal control mice, diabetic control mice, diabetic mice posttreated with standard drug glibenclamide and diabetic mice treated with P. ostreatus ethanolic extract. Blood glucose level, biochemical parameters such as serum total cholesterol, LDL, HDL, VLDL, triglyceride creatinine, urea, and Serum glutamate oxaloacetate transaminase and Serum glutamate pyruvate transaminase were studied in alloxan-induced diabetic mice after 15 days of treatment.
  
  
  RESULTS
  Animals treated with the ethanolic extract of P. ostreatus showed a significant decrease in serum glucose level (p < 0.01). The posttreatment with P. ostreatus extract reduced serum cholesterol, triglyceride and LDL-cholesterol. The serum HDL cholesterol was significantly increased in posttreated groups. The serum creatinine, urea levels were significantly reduced in posttreated group, whereas the decrease in the body weight was arrested by administration of P. ostreatus extract to the animals.
  
  
  CONCLUSIONS
  The consumption of P. ostreatus produced a significant hypoglycemic effect in diabetic mice and it is capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induced diabetic mice. Thus, indicating that the ethanolic extract of P. ostreatus could be added in the list of medicinal preparations beneficial in diabetes mellitus.
authors.affiliation: Department of Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India.
authors.forename: Bindhu
authors.initials: B
authors.lastname: Ravi
authors.forename: R Emilin
authors.initials: RE
authors.lastname: Renitta
authors.forename: M Lakshmi
authors.initials: ML
authors.lastname: Prabha
authors.forename: Reya
authors.initials: R
authors.lastname: Issac
authors.forename: Shanti
authors.initials: S
authors.lastname: Naidu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D020076:Pleurotus / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D014508:Urea; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase