title: Treatment of third-stage larvae of Toxocara cati with milbemycin oxime plus praziquantel tablets and emodepside plus praziquantel spot-on formulation in experimentally infected cats.
abstract: Toxocara cati is the most prevalent gastrointestinal helminth in cats worldwide, with cats of all ages at risk of infection. An anthelminthic treatment that not only affects the gut-dwelling stages of this parasite but is also effective against developmental stages in the tissue has the advantage that the pathology caused by migrating larvae is minimized and the need for repeated treatments is reduced. This study was conducted to evaluate the efficacy of milbemycin oxime/praziquantel tablets (Milbemax®, Novartis) against third-stage larvae of T. cati in comparison to a spot-on formulation of emodepside and praziquantel (Profender®, Bayer). Twenty-four kittens were experimentally infected with T. cati and randomly allocated to three study groups. Treatments were performed at the minimum therapeutic dosage 5 days after the experimental infection. The development of patent infections was monitored and all cats were dewormed 50 days post-infection. Efficacies were calculated based on counts of excreted worms in the treated groups compared to a negative control group. Seven of the eight cats in the negative control group developed a patent T. cati infection and all cats were excreting worms at the end of the study (geometric mean worm count 18.1). No efficacy could be observed for the milbemycin oxime-treated animals. All cats developed a patent infection and excreted worms (geometric mean worm count 27.7). The treatment with Profender® was 98.5 % effective against L3 of T. cati. One cat developed a patent infection and was excreting worms at the end of the study (geometric mean worm count 0.3). No adverse reactions were noted in either treatment group.
authors.affiliation: Institute for Parasitology, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559 Hannover, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Wolken
authors.forename: Claudia
authors.initials: C
authors.lastname: Böhm
authors.forename: Roland
authors.initials: R
authors.lastname: Schaper
authors.forename: Thomas
authors.initials: T
authors.lastname: Schnieder
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D047630:Depsipeptides / Q000008:administration & dosage* / Q000009:adverse effects; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D018942:Macrolides / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage* / Q000009:adverse effects; D014119:Toxocara / Q000187:drug effects*; D014120:Toxocariasis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D018942:Macrolides; C078973:milbemycin oxime; D011223:Praziquantel; C468987:emodepside