title: Molecular subgroups of medulloblastoma.
abstract: Recent efforts at stratifying medulloblastomas based on their molecular features have revolutionized our understanding of this morbidity. Collective efforts by multiple independent groups have subdivided medulloblastoma from a single disease into four distinct molecular subgroups characterized by disparate transcriptional signatures, mutational spectra, copy number profiles and, most importantly, clinical features. We present a summary of recent studies that have contributed to our understanding of the core medulloblastoma subgroups, focusing largely on clinically relevant discoveries that have already, and will continue to, shape research.
authors.affiliation: The Arthur & Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Northcott
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Dubuc
authors.forename: Stefan
authors.initials: S
authors.lastname: Pfister
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
mesh_terms: D002528:Cerebellar Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000145:classification / Q000235:genetics / Q000473:pathology