title: Different aspects of virus persistence (review).
abstract: The article reviews different aspects of virus persistence in human organism. Persistence is a capability acquired and strengthened in the process of evolution of many viruses that is the means of maintenance of species. Viruses of measles, poliomyelitis, mite-like encephalitis, B and C hepatitis, herpes, retro and HIV viruses persist in human organism.  Persistence is used by various viruses at various levels; they have different adaptive power and no different pathologic output. But in any case, the necessary condition is that virus should escape from elimination reactions of immune control system. At the same time, the important thing is not to save free virus but to save infected cell. While discussing long-term viral persistence, it is impossible to mark off distinctly the importance of biological participation of macroorganism and provoker in this process. The output of the relationship with infect cell is conditioned on the one hand by permissiveness of cell system, on the other hand by strain pathogen city. The details of attenuation mechanisms of microorganism's different reactions in cases of illness with the same strain are not known well yet. Although, it is clear that in chronic persistence the leading role still has immune system disbalance. In disbalance genesis of immunological equilibration virus-induced changes of immunocompetent cells are high.
authors.affiliation: Tbilisi State Medical University, Institute Medical Biotechnology, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Barnabishvili
authors.forename: T
authors.initials: T
authors.lastname: Topuria
authors.forename: P
authors.initials: P
authors.lastname: Gamtsemlidze
authors.forename: M
authors.initials: M
authors.lastname: Topuria
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D007121:Immunocompetence; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology; D014780:Viruses / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*