title: Follicular mucinosis and mycosis-fungoides-like drug eruption due to leuprolide acetate: a case report and review.
abstract: Leuprolide acetate represents a gonadotropin-releasing hormone agonist, used as part of the treatment of prostate cancer. We report an unusual case of disseminated urticarial rash following leuprolide injection in a 67-year-old man that histopathologically and immunohistochemically resembled mycosis-fungoides, including the presence of follicular mucinosis and eosinophils in the follicles. This histopathologic pattern has not been previously described as a drug reaction pattern due to leuprolide, and it underscores the importance of correlation with the clinical impression to arrive at a correct diagnosis.
authors.affiliation: Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Sara C
authors.initials: SC
authors.lastname: Shalin
authors.forename: Julie
authors.initials: J
authors.lastname: Brantley
authors.forename: A Hafeez
authors.initials: AH
authors.lastname: Diwan
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000473:pathology*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D000507:Mucinosis, Follicular / Q000139:chemically induced / Q000473:pathology; D009182:Mycosis Fungoides / Q000139:chemically induced / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide