title: Hemodynamic effects of intraocular epinephrine during cataract surgery: a double blinded placebo controlled randomized clinical trial.
abstract: OBJECTIVE
  To evaluate hemodynamic effects of intraocular epinephrine irrigation in patients undergoing cataract surgery.
  
  
  METHODS
  This study was conducted as a prospective double blinded clinical trial at the Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Eighty-eight patients of age 38-90 years undergoing were randomly allocated into two groups: Group E received intraocular irrigation fluid (balanced salt solution) with epinephrine 1:1000, 000, and group C received intraocular irrigation fluid (balanced salt solution) without epinephrine. Heart rate (HR), systolic and diastolic blood pressure (SBP, DBP) were measured before and at 5, 10, 15 minutes after starting intraocular infusion of epinephrine1:1000, 000 in both groups.
  
  
  RESULTS
  HR and SBP were similar in the two groups at different time intervals. DBP was decreased at 5 minutes after epinephrine administration in the epinephrine group and increased at 10 and 15 minutes but there was no significant differences between the two groups.
  
  
  CONCLUSIONS
  Intraocular infusion of epinephrine 1:1,000,000 can be used during cataract surgery without hemodynamic side effects and so is a safe and effective method for this purpose.
authors.affiliation: Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Seyed Ali Mohammad
authors.initials: SA
authors.lastname: Miratashi
authors.forename: Shekoufeh
authors.initials: S
authors.lastname: Behdad
authors.forename: Vida
authors.initials: V
authors.lastname: Ayatollahi
authors.forename: Afsar
authors.initials: A
authors.lastname: Ahmadi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D056965:Injections, Intraocular; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects; D012189:Retrospective Studies; D007507:Therapeutic Irrigation
chemical_list: D009184:Mydriatics; D009883:Ophthalmic Solutions; D004837:Epinephrine