title: Molecular genetic characterization of the 11q13 breakpoint in a desmoplastic fibroma of bone.
abstract: Desmoplastic fibroma (DFB) is a benign primary bone tumor that usually occurs in adolescents and young adults. The genetic information on DFB is very limited. We here present cytogenetic, fluorescence in situ hybridization and single nucleotide polymorphism array findings in a case that had a rearrangement involving chromosomes 11 and 19 at G-banding analysis. The results showed that the breakpoint in 11q was different from that in desmoplastic fibroblastomas, and a segment containing five genes was hemizygously deleted from 11q13.
authors.affiliation: Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy. d.trombetta@operapadrepio.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Trombetta
authors.forename: Gemma
authors.initials: G
authors.lastname: Macchia
authors.forename: Nils
authors.initials: N
authors.lastname: Mandahl
authors.forename: Karolin H
authors.initials: KH
authors.lastname: Nord
authors.forename: Fredrik
authors.initials: F
authors.lastname: Mertens
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics*; D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002880:Chromosomes, Human, Pair 11; D005260:Female; D018220:Fibroma, Desmoplastic / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020641:Polymorphism, Single Nucleotide