title: Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging.
abstract: Accumulation of oxidized proteins (evaluated by the levels of carbonyl and SH groups) in tissues of 2-24-month-old rats (spleen>myocardium>testicles>liver>skeletal muscles) has been demonstrated. Exogenous delta sleep-inducing peptide injected subcutaneously to rats of different age in a dose of 100 μg/kg by monthly 5-day courses protected proteins of the studied tissues from oxidation; its effect was tissue-specific. Delta sleep-inducing peptide exhibited a hypoglycemic effect: it prevented nonenzymatic glycosylation of hemoglobin and reduced the level of defective protein molecules during aging.
authors.affiliation: Southern Federal University, Rostov-on-Don, Russia. tomabon@yandex.ru
authors.forename: T I
authors.initials: TI
authors.lastname: Bondarenko
authors.forename: I A
authors.initials: IA
authors.lastname: Sorokina
authors.forename: E A
authors.initials: EA
authors.lastname: Mayboroda
authors.forename: O A
authors.initials: OA
authors.lastname: Durkanaeva
authors.forename: D S
authors.initials: DS
authors.lastname: Kutilin
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism
chemical_list: D003701:Delta Sleep-Inducing Peptide