title: Familial colon cancer syndromes: an update of a rapidly evolving field.
abstract: Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 % of CRCs have evidence of a familial component, and about 5 % are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development.
authors.affiliation: University of Colorado School of Medicine, Aurora, CO 80045, USA. Swati.Patel@ucdenver.edu
authors.forename: Swati G
authors.initials: SG
authors.lastname: Patel
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Ahnen
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000628:therapy; D045647:DNA Glycosylases / Q000235:genetics*; D055088:Early Detection of Cancer; D020022:Genetic Predisposition to Disease; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics / Q000628:therapy; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000628:therapy
chemical_list: D015815:Cell Adhesion Molecules; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase