title: Single-layer skull approximations perform well in transcranial direct current stimulation modeling.
abstract: In modeling the effect of transcranial direct current stimulation, the representation of the skull is an important factor. In a spherical model, we compared a realistic skull modeling approach, in which the skull consisted of three isotropic layers, to anisotropic and isotropic single-layer approximations. We simulated direct current stimulation for a range of conductivity values and investigated differences in the resulting current densities. Our results demonstrate that both approximation methods perform well, provided that the optimal conductivity values are used. We found that for both the anisotropic and the isotropic approximations the optimal conductivity values are largely dictated by the equivalent radial conductivity of the three-layered skull.
authors.affiliation: Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands. s.rampersad@neuro.umcn.nl
authors.forename: Sumientra M
authors.initials: SM
authors.lastname: Rampersad
authors.forename: Dick F
authors.initials: DF
authors.lastname: Stegeman
authors.forename: Thom F
authors.initials: TF
authors.lastname: Oostendorp
mesh_terms: D000200:Action Potentials / Q000502:physiology* / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000502:physiology* / Q000528:radiation effects; D003198:Computer Simulation; D004553:Electric Conductivity; D004574:Electromagnetic Fields; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology* / Q000528:radiation effects; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects; D012886:Skull / Q000502:physiology* / Q000528:radiation effects; D050781:Transcranial Magnetic Stimulation / Q000379:methods*