title: Imaging of the β-cells of the islets of Langerhans.
abstract: The major aim of this paper is to review the present status of the techniques for the non-invasive imaging and quantification of insulin-producing pancreatic islet β-cells. Emphasis is placed on both the expansion of prior work already considered in a prior review and novel achievements. Thus, the use of d-mannoheptulose analogs, hypoglycemic sulfonylureas and glinides, neural imaging agents, neuro-hormonal receptor ligands and nanoparticles is first dealt with. Thereafter, consideration is given on optical imaging technologies, the identification of new β-cells specific binding and target proteins, the functional imaging of islets transplanted into the eye anterior chamber and in vivo manganese-enhanced magnetic resonance imaging.
authors.affiliation: Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium. malaisse@ulb.ac.be
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: Kathrin
authors.initials: K
authors.lastname: Maedler
mesh_terms: D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000378:metabolism* / Q000473:pathology*; D016381:Islets of Langerhans Transplantation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008356:Mannoheptulose / Q000494:pharmacology; D053758:Nanoparticles; D061848:Optical Imaging / Q000379:methods*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D008356:Mannoheptulose