title: Cullin RING ligases: glommed by glomulin.
abstract: Cullin ring ligases (CRLs) constitute the largest group of RING finger ubiquitin ligases. Two recent studies in Molecular Cell describe glomulin as a CRL1 inhibitor that blocks interactions with its ubiquitin-conjugating enzyme (E2) (Duda et al., 2012; Tron et al., 2012). These findings and their significance are discussed.
authors.affiliation: Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
authors.forename: Ventzislava A
authors.initials: VA
authors.lastname: Hristova
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Stringer
authors.forename: Allan M
authors.initials: AM
authors.lastname: Weissman