title: Detection of M-sequences from spike sequence in neuronal networks.
abstract: In circuit theory, it is well known that a linear feedback shift register (LFSR) circuit generates pseudorandom bit sequences (PRBS), including an M-sequence with the maximum period of length. In this study, we tried to detect M-sequences known as a pseudorandom sequence generated by the LFSR circuit from time series patterns of stimulated action potentials. Stimulated action potentials were recorded from dissociated cultures of hippocampal neurons grown on a multielectrode array. We could find several M-sequences from a 3-stage LFSR circuit (M3). These results show the possibility of assembling LFSR circuits or its equivalent ones in a neuronal network. However, since the M3 pattern was composed of only four spike intervals, the possibility of an accidental detection was not zero. Then, we detected M-sequences from random spike sequences which were not generated from an LFSR circuit and compare the result with the number of M-sequences from the originally observed raster data. As a result, a significant difference was confirmed: a greater number of "0-1" reversed the 3-stage M-sequences occurred than would have accidentally be detected. This result suggests that some LFSR equivalent circuits are assembled in neuronal networks.
authors.affiliation: Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. ynishitani1027@gmail.com
authors.forename: Yoshi
authors.initials: Y
authors.lastname: Nishitani
authors.forename: Chie
authors.initials: C
authors.lastname: Hosokawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mizuno-Matsumoto
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Hajime
authors.initials: H
authors.lastname: Sawai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D006624:Hippocampus / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors