title: The chronic gastrointestinal consequences associated with campylobacter.
abstract: Campylobacteriosis is a leading cause of acute infectious diarrhea in the developing world, where it causes considerable mortality, and in developed countries, where it accounts for significant healthcare and other costs. Evidence has emerged from basic science, clinical, and epidemiological domains that suggests that Campylobacter infection is not limited to acute illness but is also involved in the development of well-described extraintestinal sequelae, such as the Guillain-Barré syndrome and reactive arthritis, and may also contribute to the pathogenesis of chronic gastrointestinal conditions. This review will focus on the role of Campylobacter infection as a risk factor for the development of chronic gastrointestinal sequelae, such as functional gastrointestinal disorders, with which irritable bowel syndrome has been most frequently associated, inflammatory bowel disease, and celiac disease.
authors.affiliation: Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910, USA. mark.riddle@med.navy.mil
authors.forename: Mark S
authors.initials: MS
authors.lastname: Riddle
authors.forename: Ramiro L
authors.initials: RL
authors.lastname: Gutierrez
authors.forename: Elena F
authors.initials: EF
authors.lastname: Verdu
authors.forename: Chad K
authors.initials: CK
authors.lastname: Porter
mesh_terms: D002167:Campylobacter / Q000472:pathogenicity*; D002169:Campylobacter Infections / Q000150:complications* / Q000453:epidemiology; D002446:Celiac Disease / Q000209:etiology*; D017281:Cost of Illness; D005767:Gastrointestinal Diseases / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000209:etiology*