title: Late evaluation of the relationship between morphological and functional renal changes and hypertension after non-operative treatment of high-grade renal injuries.
abstract: OBJECTIVE
  To evaluate the anatomical and functional renal alterations and the association with post-traumatic arterial hypertension.
  
  
  METHODS
  The studied population included patients who sustained high grades renal injury (grades III to V) successfully non-operative management after staging by computed tomography over a 16-year period. Beyond the review of medical records, these patients were invited to the following protocol: clinical and laboratory evaluation, abdominal computed tomography, magnetic resonance angiography, DMSA renal scintigraphy, and ambulatory blood pressure monitoring. The hypertensive patients also were submitted to dynamic renal scintigraphy (99mTc EC), using captopril stimulation to verify renal vascular etiology.
  
  
  RESULTS
  Of the 31 patients, there were thirteen grade III, sixteen grade IV (nine lacerations, and seven vascular lesions), and two grade V injuries. All the patients were asymptomatic and an average follow up post-injury of 6.4 years. None had abnormal BUN or seric creatinine. The percentage of renal volume reduction correlates with the severity as defined by OIS. There was no evidence of renal artery stenosis in Magnetic Resonance angiography (MRA). DMSA scanning demonstrated a decline in percentage of total renal function corresponding to injury severity (42.2 ± 5.5% for grade III, 35.3 ± 12.8% for grade IV, 13.5 ± 19.1 for grade V). Six patients (19.4%) had severe compromised function (< 30%). There was statistically significant difference in the decrease in renal function between parenchymal and vascular causes for grade IV injuries (p < 0.001). The 24-hour ambulatory blood pressure monitoring detected nine patients (29%) with post-traumatic hypertension. All the patients were male, mean 35.6 years, 77.8 % had a familial history of arterial hypertension, 66.7% had grade III renal injury, and average post-injury time was 7.8 years. Seven patients had negative captopril renography.
  
  
  CONCLUSIONS
  Late results of renal function after conservative treatment of high grades renal injuries are favorable, except for patients with grades IV with vascular injuries and grade V renal injuries. Moreover, arterial hypertension does not correlate with the grade of renal injury or reduction of renal function.
authors.affiliation: Department of Surgery and Anatomy, Division of Trauma and Emergency Surgery, University of São Paulo, Sao Paulo, Brazil. gersonapj@gmail.com.
authors.forename: Gerson Alves
authors.initials: GA
authors.lastname: Pereira Júnior
authors.forename: Valdair Francisco
authors.initials: VF
authors.lastname: Muglia
authors.forename: Antônio Carlos
authors.initials: AC
authors.lastname: Dos Santos
authors.forename: Cecilia Hissae
authors.initials: CH
authors.lastname: Miyake
authors.forename: Fernando
authors.initials: F
authors.lastname: Nobre
authors.forename: Mery
authors.initials: M
authors.lastname: Kato
authors.forename: Marcus Vinicius
authors.initials: MV
authors.lastname: Simões
authors.forename: José Ivan
authors.initials: JI
authors.lastname: de Andrade