title: Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women.
abstract: BACKGROUND
  Inflammation has been implicated in the pathogenesis of cardiovascular disease, type 2 diabetes mellitus and cancer. Serum concentration of high-sensitivity C-reactive protein is a good biomarker of chronic low-grade inflammation. Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population.
  
  
  METHODS
  The study subjects were men and women aged 49-76 years from the cohort study of lifestyle-related diseases between February 2004 and July 2006. Analysis of covariance and multiple linear regression analysis were used to estimate geometric means of high-sensitivity C-reactive protein and trends of association.
  
  
  RESULTS
  Smoking, body mass index, hypertension, type 2 diabetes mellitus, elevated non-high density lipoprotein cholesterol, prudent dietary pattern were independently associated with serum high-sensitivity C-reactive protein in both men and women. High-sensitivity C-reactive protein concentrations were lowest in men with a moderate intake of alcohol (<30 mL/day). In men, smoking and body mass index accounted for 28% and 26% of the variation in high-sensitivity C-reactive protein, respectively, while body mass index accounted for 60% of the variation of high-sensitivity C-reactive protein in women.
  
  
  CONCLUSIONS
  Smoking and body mass index in men, and body mass index in women, were major correlates of serum high-sensitivity C-reactive protein in Japanese people.
authors.affiliation: Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hirata-a@phealth.med.kyushu-u.ac.jp
authors.forename: Akie
authors.initials: A
authors.lastname: Hirata
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.forename: Makiko
authors.initials: M
authors.lastname: Morita
authors.forename: Kengo
authors.initials: K
authors.lastname: Toyomura
authors.forename: Suminori
authors.initials: S
authors.lastname: Kono
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Adachi
authors.forename: Hisaya
authors.initials: H
authors.lastname: Kawate
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000453:epidemiology
chemical_list: D002097:C-Reactive Protein