title: Inhaled nitric oxide therapy for acute respiratory distress syndrome in children.
abstract: The aim of this study was to evaluate the effects of inhaled nitric oxide (iNO) therapy on oxygenation  and mortality in children with acute respiratory distress syndrome (ARDS). Thirty-three children with ARDS and an arterial SatO2 <88% despite mechanical ventilation were analyzed. Patients in the iNO group were prospectively enrolled and treated with conventional therapy plus iNO. The control group consisted of retrospectively analyzed patients treated only with conventional therapy. A significant increase in PaO2/FiO2  ratio (25.6%) and decrease in oxygenation index (19.5%) was observed after 4 h of iNO treatment, when compared to baseline values. A positive response to iNO was detected in 69% of patients, and there was no difference between pulmonary and extrapulmonary ARDS. There was no difference in mortality and duration of mechanical ventilation between iNO and control group.
authors.affiliation: University Childrens Hospital, Belgrade, Serbia. medjo.biljana@gmail.com
authors.forename: Biljana
authors.initials: B
authors.lastname: Medjo
authors.forename: Marina
authors.initials: M
authors.lastname: Atanaskovic-Markovic
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Nikolic
authors.forename: Goran
authors.initials: G
authors.lastname: Cuturilo
authors.forename: Slobodanka
authors.initials: S
authors.lastname: Djukic
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D009569:Nitric Oxide; D010100:Oxygen