title: [ROS induction and structural modification in human lymphocyte membrane under the influence of carbon nanotubes].
abstract: To assess the potential risks of using the artificial nanostructures the structural state of the human lymphocyte membrane and lipid peroxidation under the influence of multi-walled carbon nanotubes with metal impurities was studied. The ability of carbon nanotubes to induce the formation of reactive oxygen species in cells was examined. A dose-dependent increase in reactive oxygen species formation in lymphocytes, which was not registered in cells pre-incubated with N-acetylcystein, after exposure to carbon nanotubes was shown. The addition of iron chelator deferoxamine to carbon nanotubes has also resulted in a decrease of reactive oxygen species. The mechanism of the activation of lipid peroxidation under the influence of carbon nanotubes and a structural modification of human lymphocyte membranes were discussed.
authors.forename: E V
authors.initials: EV
authors.lastname: Zhornik
authors.forename: L A
authors.initials: LA
authors.lastname: Baranova
authors.forename: A M
authors.initials: AM
authors.lastname: Strukova
authors.forename: E N
authors.initials: EN
authors.lastname: Loĭko
authors.forename: I D
authors.initials: ID
authors.lastname: Volotovskiĭ
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003676:Deferoxamine / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000009:adverse effects / Q000737:chemistry; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D037742:Nanotubes, Carbon / Q000009:adverse effects* / Q000737:chemistry; D011721:Pyrenes; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D016166:Free Radical Scavengers; D037742:Nanotubes, Carbon; D011721:Pyrenes; D017382:Reactive Oxygen Species; C030984:pyrene; D007501:Iron; D003676:Deferoxamine; D000111:Acetylcysteine