title: Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions.
abstract: The present study discusses the influence of sunlight on the photostability of levomepromazine (LV) and olanzapine (OLA) hydrochlorides in river water. Four samples of water from different rivers were used in the research. In their course, it turned out that levomepromazine easily underwent photooxidation under simulated environmental conditions, resulting in the generation of its sulphoxide. Olanzapine, on the other hand, appeared to be more resistant to sunlight, as its photodecomposition proceeded slowly, and only one product of its decomposition was detected spectrophotometrically during the process. The photodegradation was analyzed in detail using principal component analysis (PCA) and multivariate curve resolution alternating least squares (MCR-ALS) chemometric methods, and the outcomes verified by HPLC and GC-MS analysis. It can be stated that the rates of the observed processes heavily depended on the chemical composition of the fresh water used in the experiments.
authors.affiliation: Institute of Chemistry, University of Białystok, ul. Hurtowa 1, 15-399 Białystok, Poland. joasia@uwb.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Karpińska
authors.forename: Aneta
authors.initials: A
authors.lastname: Sokół
authors.forename: Anna
authors.initials: A
authors.lastname: Bernatowicz
authors.forename: Aneta
authors.initials: A
authors.lastname: Szulęcka
authors.forename: Urszula
authors.initials: U
authors.lastname: Kotowska
mesh_terms: D001569:Benzodiazepines / Q000737:chemistry / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D007700:Kinetics; D016018:Least-Squares Analysis; D008728:Methotrimeprazine / Q000737:chemistry / Q000528:radiation effects*; D000077152:Olanzapine; D010782:Photolysis; D025341:Principal Component Analysis; D045483:Rivers / Q000737:chemistry; D013454:Sulfoxides / Q000737:chemistry / Q000528:radiation effects*; D013472:Sunlight; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000528:radiation effects*
chemical_list: D013454:Sulfoxides; D014874:Water Pollutants, Chemical; D001569:Benzodiazepines; D008728:Methotrimeprazine; D000077152:Olanzapine