title: Effects of sub-acute exposure to rhodium (as Rh (III) chloride hydrate) on cytokines in female Wistar rats.
abstract: Quantitative changes in different cytokines were determined in serum of female Wistar rats exposed to Rhodium (III) chloride hydrate to evaluate its early effects on the immune system. Findings revealed an inhibitory effect of Rh salt since each cytokine, with the exceptions of IL-1α and IL-2 levels observed at the highest doses of exposure, was reduced compared to the controls and interestingly, the lowest doses induced the greatest inhibition. This generalized decrease of cytokine levels was not related to a specific cytokine pathway, and may suggest an anti-inflammatory role of Rh salt.
authors.affiliation: Institute of Occupational Medicine, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy.
authors.forename: Ivo
authors.initials: I
authors.lastname: Iavicoli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sgambato
authors.forename: Luca
authors.initials: L
authors.lastname: Fontana
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marinaccio
authors.forename: Veruscka
authors.initials: V
authors.lastname: Leso
authors.forename: Maddalena
authors.initials: M
authors.lastname: Corbi
authors.forename: Antonio
authors.initials: A
authors.lastname: Bergamaschi
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Calabrese
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012238:Rhodium / Q000633:toxicity*; D059551:Toxicity Tests, Subacute
chemical_list: D016207:Cytokines; D012238:Rhodium