title: Vitreous surgery impact in glaucoma development in liver transplanted familial amyloidosis ATTR V30M Portuguese patients.
abstract: OBJECTIVE
  Familial amyloidosis with polyneuropathy (FAP) sometimes courses with vitreous amyloid. The aim of this study was to evaluate the incidence of glaucoma after vitrectomy in FAP patients.
  
  
  METHODS
  A total of 79 eyes of 42 liver transplanted FAP patients and 16 eyes of 16 non-FAP patients with rhegmatogenous retina detachment were collected. The patients were divided in to three groups: Group I - FAP patients with vitreous opacities submitted to vitrectomy, Group II - FAP patients without vitreous opacities and not submitted to vitrectomy and, Group III - non-FAP patients with rhegmatogenous retinal detachment submitted to vitrectomy. The Group I was subdivided into: Ia - "complete" vitrectomy; Ib - "incomplete" vitrectomy. The onset of glaucoma was considered when the intraocular pressure level was higher than 21 mmHg, with concomitant visual field abnormalities and optic nerve cupping.
  
  
  RESULTS
  Post vitrectomy glaucoma was more frequent in Group I (56.1%) than in Group III (12.5%) and in Group II (10.5%). We observed a higher incidence of glaucoma in the Ia than in the Ib subgroup (86.4 vs. 21.1%) and earlier appearance in subgroup Ia (7.9 ± 3.6 vs. 39.5 ± 6.6 months).
  
  
  CONCLUSIONS
  Vitrectomy induced the development of glaucoma in FAP patients.
authors.affiliation: Opthalmology Department, Hospital de Santo António-Centro Hospitalar do Porto, Porto, Portugal. bbeirao@iol.pt
authors.forename: Nuno M
authors.initials: NM
authors.lastname: Beirão
authors.forename: Maria E
authors.initials: ME
authors.lastname: Matos
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Meneres
authors.forename: Idalina M
authors.initials: IM
authors.lastname: Beirão
authors.forename: Paulo P
authors.initials: PP
authors.lastname: Costa
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Torres
mesh_terms: D000328:Adult; D000682:Amyloid / Q000235:genetics; D028227:Amyloid Neuropathies, Familial / Q000453:epidemiology / Q000235:genetics / Q000601:surgery*; D005260:Female; D005901:Glaucoma / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure; D008107:Liver Diseases / Q000453:epidemiology / Q000235:genetics / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D011228:Prealbumin / Q000235:genetics; D014821:Vitrectomy / Q000009:adverse effects*; D014822:Vitreous Body / Q000473:pathology / Q000601:surgery
chemical_list: D000682:Amyloid; D011228:Prealbumin; C076571:transthyretin-related amyloid fibril protein, human