title: A comparison of the application of fibrin glue and adhesive film for repair of anastomotic leaks in the rat.
abstract: BACKGROUND
  Anastomotic leaks constitute one of the most serious intraoperative complications and although many studies have been devoted to finding a solution for this problem, none of them has yet been able offer a decisive, successful method. In this study, the ability of fibrin glue and adhesive film to repair anastomotic leaks in an experimental model was compared.
  
  
  METHODS
  The sample comprised four groups of seven rats: Group 1 (Control): the distal colon was transected and anastomosis was performed. Group 2 (Primary repair): incomplete anastomosis produced a leak that was closed by primary repair on day 3. Group 3 (Fibrin glue): incomplete anastomosis produced a leak that was closed by primary repair and fibrin glue applied on day 3. Group 4 (Adhesive film): incomplete anastomosis produced a leak that was closed by primary repair and adhesive film was applied on day 3. The rats were sacrificed on day 6 following anastomosis. Anastomotic blast compressions were measured and fibroblast activation, inflammation, neovascularization and levels of collagen were evaluated.
  
  
  RESULTS
  The results from Group 4 showed that blast compression values were high and statistically significantly increased over control values (p < 0.05). Inflammation in Group 2 was significantly higher than the other groups (p < 0.05). No significant differences were detected in the comparison of the groups regarding the other scoring criteria (p > 0.05).
  
  
  CONCLUSIONS
  Adhesive film is more effective in reducing anastomotic leakage than fibrin glue.
authors.affiliation: Meram Education and Research Hospital, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Ayhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erikoglu
authors.forename: Süleyman S
authors.initials: SS
authors.lastname: Tavli
authors.forename: Hatice
authors.initials: H
authors.lastname: Toy
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects*; D000818:Animals; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007431:Intraoperative Complications / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D014014:Tissue Adhesives / Q000494:pharmacology*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives