title: 5-HT(1A) receptor binding changes in patients with major depressive disorder before and after antidepressant treatment: a pilot [¹⁸F]MPPF positron emission tomography study.
abstract: This is the first [¹⁸F]MPPF PET study in positron emission tomography study in depressed patients, both before and after treatment with a selective serotonin reuptake inhibitor (SSRI). Dynamic changes in [¹⁸F]MPPF binding potential were observed primarily in the medial orbital regions from baseline to 30 days of treatment, suggesting SSRI-mediated serotoninergic adaptative mechanisms.
authors.affiliation: Université de Lyon, Lyon, France. amelie.lothe@cermep.fr
authors.forename: Amélie
authors.initials: A
authors.lastname: Lothe
authors.forename: Mohamed
authors.initials: M
authors.lastname: Saoud
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bouvard
authors.forename: Jérôme
authors.initials: J
authors.lastname: Redouté
authors.forename: Jérôme
authors.initials: J
authors.lastname: Lerond
authors.forename: Philippe
authors.initials: P
authors.lastname: Ryvlin
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005462:Fluorine Radioisotopes; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000378:metabolism*; D058829:Serotonin 5-HT1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D044282:Receptor, Serotonin, 5-HT1A; D058829:Serotonin 5-HT1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors