title: Synthesis, reactivity, and resolution of a C2-symmetric, P-stereogenic benzodiphosphetane, a building block for chiral bis(phosphines).
abstract: Although the pyramidal inversion barriers in diphosphines (R(2)P-PR(2)) are similar to those in phosphines (PR(3)), P-stereogenic chiral diphosphines have rarely been exploited as building blocks in asymmetric synthesis. The synthesis, reactivity, and resolution of the benzodiphosphetane trans-1,2-(P(t-Bu))(2)C(6)H(4) are reported. Alkylation with MeOTf followed by addition of a nucleophile gave the useful C(2)-symmetric P-stereogenic ligand BenzP* and novel analogues.
authors.affiliation: 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States.
authors.forename: Samantha C
authors.initials: SC
authors.lastname: Reynolds
authors.forename: Russell P
authors.initials: RP
authors.lastname: Hughes
authors.forename: David S
authors.initials: DS
authors.lastname: Glueck
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold