title: Changes in the levels of N-cadherin and PCNA in skin melanoma cells are mediated through matrix metalloproteinase 9.
abstract: Immunohistochemical studies revealed increased level of matrix metalloproteinase 9 in skin melanoma cells. Inhibition of matrix metalloproteinase 9 with interfering RNA changed the level of PCNA and reduced N-cadherin content in melanoma cells. This attests to the involvement of matrix metalloproteinase 9 in the realization of invasion and metastatic growth and in the regulation of tumor growth and progress.
authors.affiliation: VV Ivanov Department of Pathophysiology with a Clinical Pathophysiology Course, VF VoinoYasenetsky State Medical University, Krasnoyarsk, Russia. aksenenko_mariya@mail.ru
authors.forename: M B
authors.initials: MB
authors.lastname: Aksenenko
authors.forename: S N
authors.initials: SN
authors.lastname: Gyrylova
authors.forename: T G
authors.initials: TG
authors.lastname: Ruksha
mesh_terms: D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism*; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D015820:Cadherins; D018809:Proliferating Cell Nuclear Antigen; D020780:Matrix Metalloproteinase 9