title: Vascular effects of aqueous extract of Chamaemelum nobile: in vitro pharmacological studies in rats.
abstract: This study aims to evaluate the in vitro vasorelaxant effect of C. nobile aqueous extract. We use aortic ring isolated from Wistar rats and aqueous C. nobile extract at doses of 5, 10 and 20 mg/ml. Incubation of aqueous C. nobile extract for 30 minutes produced a significant shift of the dose-response curve to norepinephrine (NE) (10(-8) to 10(-5) M) (p < 0.001). This study demonstrates that aqueous C. nobile extract possesses in vitro vasorelaxant effect.
authors.affiliation: Moulay Ismail University, Errachidia, Morocco.
authors.forename: Naoufel Ali
authors.initials: NA
authors.lastname: Zeggwagh
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Michel
authors.forename: Mohamed
authors.initials: M
authors.lastname: Eddouks
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D031167:Chamaemelum; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D014665:Vasodilator Agents