title: The role of number of meals, coffee intake, salt and type of cookware on colorectal cancer development in the context of the Mediterranean diet.
abstract: OBJECTIVE
  To investigate the association between dietary behaviours and colorectal cancer (CRC) in the context of the Mediterranean diet.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  All patients (cases) were recruited from Saint Savvas Cancer Hospital and Alexandra General Hospital in Athens, Greece. Controls were voluntarily selected from the general population and matched to cases by age group (±10 years) and sex.
  
  
  METHODS
  Two hundred and fifty cases with newly diagnosed CRC (mean age 63 (sd 12) years, 59·6 % males) and 250 controls matched on age and sex were studied. A standardized questionnaire assessing sociodemographic, clinical, lifestyle, dietary characteristics and nutritional behaviours was applied. Multiple logistic regression analysis was used to evaluate the aforementioned factors in addition to the MedDietScore (an index that evaluates adherence to the Mediterranean diet) on CRC development.
  
  
  RESULTS
  The higher the daily number of meals, the lower the likelihood of having CRC (OR = 0·74, 95 % CI 0·61, 0·89); coffee drinking was associated with higher likelihood of having CRC (OR = 3·27, 95 % CI 1·09, 9·8); the use of non-stick cookware was positively associated with CRC (OR = 1·57, 95 % CI 1·02, 2·4). However, these associations slightly lost their significance when adherence to the Mediterranean diet was taken into account. Moreover, a 1/75 increase in the modified-MedDietScore plus the aforementioned nutritional behaviours was associated with 13 % lower odds (95 % CI 0·83, 0·91, P < 0·001) of having CRC.
  
  
  CONCLUSIONS
  Nutritional behaviours in addition to dietary habits should be taken into account in detecting individuals prone to the development of CRC.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Niki
authors.initials: N
authors.lastname: Kontou
authors.forename: Theodora
authors.initials: T
authors.lastname: Psaltopoulou
authors.forename: Nick
authors.initials: N
authors.lastname: Soupos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Polychronopoulos
authors.forename: Athena
authors.initials: A
authors.lastname: Linos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Xinopoulos
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
mesh_terms: D000368:Aged; D000428:Alcohol Drinking; D016022:Case-Control Studies; D003069:Coffee; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D038441:Diet, Mediterranean; D005247:Feeding Behavior; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D062407:Meals; D008875:Middle Aged; D010349:Patient Compliance; D012307:Risk Factors; D012959:Socioeconomic Factors; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D011795:Surveys and Questionnaires
chemical_list: D003069:Coffee; D017673:Sodium Chloride, Dietary