title: Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
abstract: OBJECTIVE
  Genetic variation may influence chemotherapy response and overall survival in cancer patients.
  
  
  METHODS
  We conducted a genome-wide scan in 535 advanced-stage non-small cell lung cancer (NSCLC) patients from two independent cohorts (307 from Nanjing and 228 from Beijing). A replication was carried out on an independent cohort of 340 patients from Southeastern China followed by a second validation on 409 patients from the Massachusetts General Hospital (Boston, MA).
  
  
  RESULTS
  Consistent associations with NSCLC survival were identified for five single-nucleotide polymorphisms (SNP) in Chinese populations with P values ranging from 3.63 × 10(-5) to 4.19 × 10(-7) in the additive genetic model. The minor allele of three SNPs (rs7629386 at 3p22.1, rs969088 at 5p14.1, and rs3850370 at 14q24.3) were associated with worse NSCLC survival while 2 (rs41997 at 7q31.31 and rs12000445 at 9p21.3) were associated with better NSCLC survival. In addition, rs7629386 at 3p22.1 (CTNNB1) and rs3850370 at 14q24.3 (SNW1-ALKBH1-NRXN3) were further replicated in the Caucasian population.
  
  
  CONCLUSIONS
  In this three-stage genome-wide association studies, we identified five SNPs as markers for survival of advanced-stage NSCLC patients treated with first-line platinum-based chemotherapy in Chinese Han populations. Two of these SNPs, rs7629386 and rs3850370, could also be markers for survival among Caucasian patients.
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
authors.forename: Lingmin
authors.initials: L
authors.lastname: Hu
authors.forename: Chen
authors.initials: C
authors.lastname: Wu
authors.forename: Xueying
authors.initials: X
authors.lastname: Zhao
authors.forename: Rebecca
authors.initials: R
authors.lastname: Heist
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Baohui
authors.initials: B
authors.lastname: Han
authors.forename: Songyu
authors.initials: S
authors.lastname: Cao
authors.forename: Minjie
authors.initials: M
authors.lastname: Chu
authors.forename: Juncheng
authors.initials: J
authors.lastname: Dai
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Shu
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Yijiang
authors.initials: Y
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.forename: Dianke
authors.initials: D
authors.lastname: Yu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ma
authors.forename: Jiaping
authors.initials: J
authors.lastname: Chen
authors.forename: Guangfu
authors.initials: G
authors.lastname: Jin
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Hu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016019:Survival Analysis; D044465:White People / Q000235:genetics; D051176:beta Catenin / Q000235:genetics*
chemical_list: C495270:CTNNB1 protein, human; D051176:beta Catenin; D016190:Carboplatin; D002945:Cisplatin