title: 13-Week oral toxicity study of oil derived from squid (Todarodes pacificus) in Sprague-Dawley rats.
abstract: Recommendations to increase the consumption of the long-chain omega-3 fatty acids are challenged by the global problem of declining fish stocks. Non-traditional and more sustainable sources of the long-chain omega-3 fatty acids are needed. Squid (Todarodes pacificus) represents a uniquely sustainable source of these fatty acids. A 13-week oral toxicity study was conducted in male and female Sprague-Dawley rats administered either 0, 250, 500, or 1000μl/kg body weight (bw)/day of a refined squid oil. All of the rats survived through to the end of the study. All of the rats grew normally and had normal clinical and ophthalmic observations. No signs of toxicity were evident from clinical chemistry, hematology, and urinalysis data measured. No abnormal findings attributable to exposure to purified squid oil were observed following the necropsy of male and female rats and the histopathological examination of the organs. The no-observed-adverse-effect level for refined squid oil was determined to be 1000μl/kg bw/day, the highest dose tested.
authors.affiliation: Institute for Research & Industry Cooperation, Pukyong National University, Busan 608-739, South Korea.
authors.forename: Joung-Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Kathy
authors.initials: K
authors.lastname: Musa-Veloso
authors.forename: Barry
authors.initials: B
authors.lastname: Lynch
authors.forename: Heather
authors.initials: H
authors.lastname: Leslie
authors.forename: Kyo-Hwan
authors.initials: KH
authors.lastname: Koo
authors.forename: Seon-Bong
authors.initials: SB
authors.lastname: Kim
authors.forename: Suk-Nam
authors.initials: SN
authors.lastname: Kang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D049832:Decapodiformes; D015525:Fatty Acids, Omega-3 / Q000633:toxicity*; D005260:Female; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009821:Oils / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D059550:Toxicity Tests, Subchronic
chemical_list: D015525:Fatty Acids, Omega-3; D009821:Oils