title: Biomineralization: a proposed evolutionary origin for inorganic cofactors of enzymes.
abstract: In this paper, three different reactions of nanoparticles and proteins are explained. As a model system, the interactions of birnessite, which is a common manganese oxide in the environment, and bovine serum albumin, as a protein that has a strong affinity for a variety of inorganic molecules, are studied. The author proposes that the cofactor-formation in particular enzymes may be considered as a biomineralization in the presence of the protein. One of the numerous and very small nanoparticles produced in the presence of protein could be formed in an appropriate location in proteins and be used as a primitive inorganic core (cofactor) of enzyme.
authors.affiliation: Department of Chemistry, Center of Climate Change and Global Warming, Institute for Advanced Studies in Basic Sciences, 45195-1159 Gava Zang, Zanjan, Iran. mmnajafpour@iasbs.ac.ir
authors.forename: Mohammad Mahdi
authors.initials: MM
authors.lastname: Najafpour
mesh_terms: D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D002412:Cations / Q000737:chemistry / Q000378:metabolism; D003067:Coenzymes / Q000737:chemistry* / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D019418:Evolution, Chemical; D008345:Manganese / Q000737:chemistry / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008903:Minerals / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry*; D045332:Photosystem II Protein Complex / Q000737:chemistry / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D002412:Cations; D003067:Coenzymes; D004798:Enzymes; D008903:Minerals; D010087:Oxides; D045332:Photosystem II Protein Complex; C505018:birnessite; D012710:Serum Albumin, Bovine; D008345:Manganese; D002118:Calcium