title: The Efficacy and Safety of 17α-Estradiol (Ell-Cranell® alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study.
abstract: BACKGROUND
  There are several commercially available agents to treat female pattern hair loss (FPHL), including minoxidil solution, anti-androgen agents and mineral supplements. However, these treatments are not always satisfactory. We report the results of a clinical trial of 17α-estradiol (Ell-Cranell® alpha 0.025%) solution to Korean female patients with FPHL.
  
  
  OBJECTIVE
  This study was designed to examine the efficacy and safety of Ell-Cranell® alpha 0.025% solution in Korean female patients with FPHL.
  
  
  METHODS
  A total of 53 women, 18 to 55 years old, applied topical Ell-Cranell® alpha 0.025% solution once daily for 8 months. Efficacy was evaluated by the change of hair counts and diameter, subjective assessment, and photographic assessment by investigators.
  
  
  RESULTS
  Hair counts and diameter from baseline to 4 and 8 months after treatment increased in treated patients and these changes were statistically significant (p<0.0001). 17α-estradiol (Ell-Cranell® alpha 0.025%) solution showed significant improvement by subjective self-assessment and by investigator photographic assessment. Ell-Cranell® alpha 0.025% solution was well tolerated over 8-months period.
  
  
  CONCLUSIONS
  This study showed that Ell-Cranell® alpha 0.025% solution is a safe and effective agent for Korean women with FPHL.
authors.affiliation: Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Sung Yul
authors.initials: SY
authors.lastname: Lee
authors.forename: Hae-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Yoon
authors.forename: Won-Soo
authors.initials: WS
authors.lastname: Lee