title: Oxidation and endothelial dysfunction biomarkers of atherosclerotic plaque instability. Studies of the vascular wall and blood.
abstract: The concentrations of LPO products (including those present in LDL), oxidative modification of proteins, paraoxonase activity, concentrations of antioxidants, lipid values and biomarkers of endothelial dysfunction were studied in the blood and coronary artery intima/media of male patients with coronary atherosclerosis without acute coronary syndrome. Blood levels of LDL oxidized apolipoproteins and lipoprotein (a) were higher, while the content of NO metabolites, sVCAM endothelial adhesion molecules, and LDL oxidation resistance were lower in men with mainly unstable atherosclerotic plaques in the coronary arteries in comparison with men with mainly stable plaques in the coronary arteries. Of these blood biomarkers, only NO metabolites, oxidized proteins, and sVCAM correlated with the presence of unstable atherosclerotic plaques. A significant correlation between the levels of biomarkers in the vascular wall and blood was detected only for LPO parameters.
authors.affiliation: Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. ragino@mail.ru
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.forename: A M
authors.initials: AM
authors.lastname: Chernjavski
authors.forename: Ya V
authors.initials: YV
authors.lastname: Polonskaya
authors.forename: A M
authors.initials: AM
authors.lastname: Volkov
authors.forename: E V
authors.initials: EV
authors.lastname: Kashtanova
authors.forename: A V
authors.initials: AV
authors.lastname: Tikhonov
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tcimbal
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism; D017540:Tunica Media / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL