title: Is abnormal 50-g glucose-challenge testing an independent predictor of adverse pregnancy outcome?
abstract: OBJECTIVE
  To determine whether an abnormal 50-g glucose-challenge test (GCT) is independently associated with adverse pregnancy outcome.
  
  
  METHODS
  A retrospective study of women with abnormal GCT (>140 mg/dL) but normal subsequent 100-g oral glucose-tolerance test (OGTT). Pregnancy outcome was compared with that of women with normal GCT (<140 mg/dL).
  
  
  RESULTS
  Of the 79,153 women delivered during the study period, the results of the GCT were available for 14,268. Of these, 809 (5.7%) had an abnormal GCT and normal OGTT and were eligible for the study group. An abnormal GCT was independently associated with an increased risk for macrosomia (odds ratio [OR] = 2.0, 95% CI: 1.5-2.7), large for gestational age (OR = 1.6, 95% CI: 1.3-2.0), cesarean section (OR = 1.3, 95% CI: 1.1-1.6), respiratory morbidity (OR = 1.6, 95% CI: 1.1-2.7) and neonatal hypoglycemia (OR = 1.8, 95% CI: 1.1-3.2). In contrast, an abnormal GCT was associated with decreased risk for preterm delivery at less than 37 weeks (OR = 0.7, 95% CI: 0.5-0.9) and 34 weeks (OR = 0.3, 95% CI: 0.1-0.6). The association between abnormal GCT and adverse pregnancy outcome was unrelated to the degree of GCT abnormality except for cases in which the GCT was extremely high (≥180 mg/dL).
  
  
  CONCLUSIONS
  Women with abnormal-GCT result are at increased risk for adverse pregnancy outcome even in the presence of a normal subsequent OGTT.
authors.affiliation: Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Melamed
authors.forename: Liran
authors.initials: L
authors.lastname: Hiersch
authors.forename: Moshe
authors.initials: M
authors.lastname: Hod
authors.forename: Rony
authors.initials: R
authors.lastname: Chen
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Yariv
authors.initials: Y
authors.lastname: Yogev
mesh_terms: D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000494:pharmacology; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D005947:Glucose