title: Selective photothermal therapy for breast cancer with targeting peptide modified gold nanorods.
abstract: In this work, we prepared polyacrylic acid (PAA) coated gold nanorods (GNRs) and then the targeting peptide modified GNRs. The biocompatibility and stability of functionalized GNRs were investigated by monitoring the surface plasmon resonance (SPR) absorption intensity. The efficacy of targeted thermal therapy can be significantly enhanced via decoration with surface-bound peptide which was obtained through phage display technology. In addition, the photothermal therapy was monitored in real time with the multi-channel function of a confocal laser scanning microscope (CLSM) coupled with an 808 nm laser. This selective photothermal therapy of GNRs is a promising candidate for phototherapeutic applications.
authors.affiliation: State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, P R China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.forename: Boting
authors.initials: B
authors.lastname: Chen
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Jiang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D001943:Breast Neoplasms / Q000628:therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010789:Phototherapy; D020349:Surface Plasmon Resonance
chemical_list: D000180:Acrylic Resins; D019151:Peptide Library; D010455:Peptides; C006903:carbopol 940; D006046:Gold