title: Effects of oriental sweet gum storax on porcine wound healing.
abstract: OBJECTIVE
  The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model.
  
  
  METHODS
  Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 × 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured.
  
  
  RESULTS
  In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups.
  
  
  CONCLUSIONS
  The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects.
authors.affiliation: Department of Plastic and Reconstructive Surgery, School of Medicine, Pamukkale University,   Denizli,   Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ocsel
authors.forename: Zafer
authors.initials: Z
authors.lastname: Teke
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sacar
authors.forename: Burhan
authors.initials: B
authors.lastname: Kabay
authors.forename: S Ender
authors.initials: SE
authors.lastname: Duzcan
authors.forename: Inci Gokalan
authors.initials: IG
authors.lastname: Kara
mesh_terms: D000818:Animals; D003102:Colloids / Q000494:pharmacology; D004848:Epithelium / Q000503:physiopathology; D006097:Granulation Tissue / Q000503:physiopathology; D006909:Hydroxyproline / Q000032:analysis; D031317:Liquidambar; D008517:Phytotherapy; D012038:Regeneration; D012837:Silver Sulfadiazine / Q000494:pharmacology; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003102:Colloids; D006909:Hydroxyproline; D012837:Silver Sulfadiazine