title: Binary mechanism of action of cognition enhancer NT1505 on glutamate receptors.
abstract: Compound NT1505 potentiates AMPA receptors in rat brain neurons and simultaneously noncompetitively blocks NMDA receptors via two different mechanisms. Considering previously obtained data on strong cognition-enhancing properties of this compound we can conclude that NT1505 is a novel cognition stimulator exhibiting properties of a positive modulator of AMPA receptors and a blocker NMDA receptor.
authors.affiliation: Laboratory of Neurochemistry of Physiologically Active Compounds, Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia. grigor@ipac.ac.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Grigoriev
authors.forename: A N
authors.initials: AN
authors.lastname: Proshin
authors.forename: A S
authors.initials: AS
authors.lastname: Kinzirskii
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004594:Electrophysiology; D018697:Nootropic Agents / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D018091:Receptors, AMPA / Q000819:agonists / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000378:metabolism
chemical_list: D018697:Nootropic Agents; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate