title: Pd-catalyzed C-3 functionalization of indolizines via C-H bond cleavage.
abstract: New transition metal-catalyzed methods for the arylation of indolizines by the direct cleavage of C-H bonds have been developed. A wide range of aryltrifluoroborate salts react with indolizines in the presence of Pd(OAc)(2) catalyst and AgOAc oxidant to give the arylated indolizines in high yields. Both electron-donating and electron-withdrawing groups perform smoothly while bromide and chlorine substituents are tolerated. In addition, the indolizines display similar reactivities in the Pd-catalyzed reaction with 3-phenylpropiolic acid to afford the corresponding C-3 alkynylated indolizines. These methods allow the direct functionalization of indolizines in one step.
authors.affiliation: Institute of Applied Chemistry and Department of Chemistry, University of Shaoxing, Shaoxing, Zhejiang Province 312000, People's Republic of China. babygarfield@126.com
authors.forename: Baoli
authors.initials: B
authors.lastname: Zhao