title: Optimal strategy for controlling the spread of HIV/AIDS disease: a case study of South Africa.
abstract: HIV/AIDS disease continues to spread alarmingly despite the huge amounts of resources invested in fighting it. There is a need to integrate the series of control measures available to ensure a consistent reduction in the incidence of the disease pending the discovery of its cure. We present a deterministic model for controlling the spread of the disease using change in sexual habits and antiretroviral (ARV) therapy as control measures. We formulate a fixed time optimal control problem subject to the model dynamics with the goal of finding the optimal combination of the two control measures that will minimize the cost of the control efforts as well as the incidence of the disease. We estimate the model state initial conditions and parameter values from the demographic and HIV/AIDS data of South Africa. We use Pontryagin's maximum principle to derive the optimality system and solve the system numerically. Compared with the practice in most resource-limited settings where ARV treatment is given only to patients with full-blown AIDS, our simulation results suggest that starting the treatment as soon as the patients progress to the pre-AIDS stage of the disease coupled with appreciable change in the susceptible individuals' sexual habits reduces both the incidence and prevalence of the disease faster. In fact, the results predict that the implementation of the proposed strategy would drive new cases of the disease towards eradication in 10 years.
authors.affiliation: Department of Mathematics and Applied Mathematics, University of the Western Cape, Bellville, 7535, South Africa. ttyusuf@yahoo.com
authors.forename: Tunde T
authors.initials: TT
authors.lastname: Yusuf
authors.forename: Francis
authors.initials: F
authors.lastname: Benyah
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000517:prevention & control*; D004812:Epidemiologic Methods; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D011157:Population Dynamics; D015995:Prevalence; D013019:South Africa / Q000453:epidemiology