title: Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.
abstract: BACKGROUND
  Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP).
  
  
  METHODS
  Outpatient blood pressure data over an approximate 8-year period was collected from the Veterans Affairs Hypertensive Cohort (N = 1,302). Association between genotype and longitudinal MAP was further explored using a random effects model controlling for age, ancestry, renal function, and other determinants of blood pressure. To control for population stratification, principal component groupings based on ancestry informative markers in this dataset were included as covariates (in addition to self-identified ancestry). Data from the African American Study of Kidney Disease and Hypertension (AASK, N = 857) was used to confirm significant findings in an independent cohort.
  
  
  RESULTS
  There was a significant interaction between PON1-108 C/T genotype and follow-up age group. At a younger age (<50 years), there was an estimated 2.53 mm Hg (95% confidence interval: 1.06, 4.00) increase in MAP with each additional C-allele. At the older age groups, there were no significant associations between PON1-108 C/T genotype and MAP. Using data from the AASK trial, the C-allele at PON1-108 C/T was significantly associated with a higher MAP (P = 0.005) but only among younger participants (<54 years).
  
  
  CONCLUSIONS
  The PON1-108 polymorphism may be associated with MAP in an age-dependent manner.
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. vbhatnag@ucsd.edu
authors.forename: Vibha
authors.initials: V
authors.lastname: Bhatnagar
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Nievergelt
authors.forename: Erin
authors.initials: E
authors.lastname: Richard
authors.forename: Victoria H
authors.initials: VH
authors.lastname: Brophy
authors.forename: Braj
authors.initials: B
authors.lastname: Pandey
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lipkowitz
authors.forename: Daniel T
authors.initials: DT
authors.lastname: O'Connor
mesh_terms: D000368:Aged; D062186:Arterial Pressure; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D043303:Aryldialkylphosphatase