title: Evaluation of etiologic and prognostic factors in neonatal convulsions.
abstract: This study evaluated etiologic and risk factors affecting long-term prognoses of neurologic outcomes in newborns with neonatal seizures. We enrolled patients at chronologic ages of 23-44 months, referred to the Department of Pediatric Neurology, Istanbul Medical Faculty, from January 1, 2007-December 31, 2009, after manifesting seizures in their first postnatal 28 days. Of 112 newborns, 41 were female, 71 were male, 33 were preterm, and 79 were full-term. Perinatal asphyxia (28.6%) and intracranial hemorrhage (17%) were the most common causes of neonatal seizures. Cerebral palsy developed in 27.6% of patients during follow-up. The incidence of epilepsy was 35.7%. Almost 50% of patients manifested developmental delay in one or more areas. Global developmental delay was the most common (50.8%) neurologic disorder. The correlation between gestational age or birth weight and adverse outcomes was nonsignificant. Etiology, Apgar score, need for resuscitation at birth, background electroencephalogram, neonatal status epilepticus, cranial imaging findings, type/duration of antiepileptic treatment, and response to acute treatment were all strong prognostic factors in neurologic outcomes. Neonatal seizures pose a threat of neurologic sequelae for preterm and full-term infants. Although the number of recognized etiologic factors in neonatal seizures has increased because of improvements in neonatology and diagnostic methods, perinatal asphyxia remains the most common factor.
authors.affiliation: Department of Pediatrics, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Edibe Pembegul
authors.initials: EP
authors.lastname: Yıldız
authors.forename: Burak
authors.initials: B
authors.lastname: Tatlı
authors.forename: Barış
authors.initials: B
authors.lastname: Ekici
authors.forename: Emine
authors.initials: E
authors.lastname: Eraslan
authors.forename: Nur
authors.initials: N
authors.lastname: Aydınlı
authors.forename: Mine
authors.initials: M
authors.lastname: Calışkan
authors.forename: Meral
authors.initials: M
authors.lastname: Ozmen
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000150:complications; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000150:complications; D002547:Cerebral Palsy / Q000209:etiology; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008659:Metabolic Diseases / Q000150:complications; D009422:Nervous System Diseases / Q000209:etiology; D059906:Neuroimaging; D009460:Neurologic Examination; D011379:Prognosis; D012640:Seizures / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants