title: Immunogenicity of a monovalent pandemic influenza A H1N1 virus vaccine with or without prior seasonal influenza vaccine administration.
abstract: The immunogenicity of pandemic influenza A H1N1 virus (A/H1pdm) vaccine might be modified by prior seasonal trivalent influenza vaccine (sTIV) administration. We conducted a retrospective analysis of immunogenicity of 243 health care workers (number of sTIV-positive [sTIV(+)] subjects, 216; number of sTIV(-) subjects, 27) by hemagglutination inhibition. There was no significant difference in the ratios of antibody titers of ≥40 (41.2% versus 48.1%; P = 0.49) and fold increases in geometric mean titer (3.8 versus 4.5; P = 0.37). sTIV injected 7 to 10 days prior to A/H1pdm vaccine administration did not interfere with the immunogenicity of the latter.
authors.affiliation: Divisions of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan. hide306@gmail.com
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Igari
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Segawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Mariko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Watanabe
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Mikio
authors.initials: M
authors.lastname: Nakayama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Sato
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D006282:Health Personnel; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D058873:Pandemics / Q000517:prevention & control; D012189:Retrospective Studies; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated