title: Infusion of noradrenaline through the proximal line of a migrated central venous catheter.
abstract: A 41-year-old, obese, patient was admitted to Accident and Emergency with a history of leg cellulitis. A central line was inserted. Documented aspiration of blood from all lines, central venous pressure trace obtained and correct position noted on the chest X-ray (CXR). The patient became increasingly septic despite antibiotic therapy. He was subsequently commenced on a noradrenaline infusion; however, the blood pressure was unresponsive. On admission to the intensive care unit (ICU), it was noted he had an area of white skin over the right clavicle. The infusions were stopped and a CXR confirmed proximal migration of the line. The central line was re-sited and his noradrenaline recommenced with an improvement in his blood pressure. Acute renal failure developed which required haemofiltration for 24 hours. The condition improved and the patient was discharged from ICU. It took several weeks for his renal function to return to normal, but he was discharged home with no permanent damage.
authors.affiliation: Department of Anaesthesia and Critical Care Medicine, Victoria Infirmary Hospital, Glasgow, Scotland, UK. matthewfreer@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Freer
authors.forename: S
authors.initials: S
authors.lastname: Noble
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D000328:Adult; D062186:Arterial Pressure / Q000187:drug effects; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002481:Cellulitis / Q000628:therapy*; D003422:Critical Care / Q000379:methods; D004636:Emergency Service, Hospital; D005548:Foreign-Body Migration / Q000175:diagnosis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage*; D009765:Obesity / Q000150:complications; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology
chemical_list: D009638:Norepinephrine