title: [Preparation and performance of controlled-release tablets of sasanquasaponin-casein].
abstract: The controlled-release tablets of sasanquasaponin (SQS)-casein were prepared by using SQS, casein and guar gum as the main drug and accessory materials respectively. The method of determination of SQS in the controlled-release tablets of SQS-casein, and the effects of release media on the release rate and IR spectra of the controlled-release tablets of SQS-casein were studied, respectively. The release rate curve of the controlled-release tablets of SQS-casein was fitted as zero order, one order and Higuchi equation. The recovery was 98.59% when the content of SQS in the controlled-release tablets of SQS-casein in phosphate buffer solution (pH 6.8) as release media was determined with chromogenic reaction of vanillin- sulfuric acid. The release rates are 23.80%, 51.26% and 94.77% at release times 3, 6 and 12 h, respectively in phosphate buffer solution (pH 6.8) as release media. The controlled-release tablets of SQS-casein release SQS by slowness and constant in 12 h. The chemical bonds are formed among SQS, casein and guar gum.
authors.affiliation: School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 200235, China. liuxiaozhen1958@yahoo.com
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Liu
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Yang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Song
authors.forename: Yue-Xing
authors.initials: YX
authors.lastname: Song
authors.forename: Zhong-Fan
authors.initials: ZF
authors.lastname: Lai
authors.forename: Li
authors.initials: L
authors.lastname: Zhai
mesh_terms: D002364:Caseins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D012503:Saponins / Q000737:chemistry*; D013607:Tablets
chemical_list: C497504:22-O-angeloylcamelliagenin C-3-O-(glucopyranosyl-1-2)(glucopyranosyl-1-2-O-arabinopyranosyl-1-3-)glucopyranosiduronic acid; D002364:Caseins; D003692:Delayed-Action Preparations; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D012503:Saponins; D013607:Tablets; C007894:guar gum