title: Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.
abstract: The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
authors.affiliation: Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, NO-0027 Oslo, Norway. jorrit.enserink@rr-research.no
authors.forename: Jorrit M
authors.initials: JM
authors.lastname: Enserink
mesh_terms: D055808:Drug Discovery; D053263:Gene Regulatory Networks; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects / Q000235:genetics; D058977:Molecular Sequence Annotation; D009154:Mutation; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics*