title: The contribution of patient interviews to the identification of drug-related problems in home medication review.
abstract: OBJECTIVE
  To determine to what extent patient interviews contribute to the identification of drug-related problems (DRPs) in home medication reviews, in terms of number, type and clinical relevance.
  
  
  METHODS
  We performed a cross-sectional study within the intervention arm of a randomized controlled trial. Patients were recruited from 10 Dutch community pharmacies. Patients were eligible if they were home-dwelling, aged 65 years and over and used five or more different drugs, including at least one cardiovascular or antidiabetic drug. The community pharmacist interviewed the patient at home about the medicines and identified potential DRPs in combination with medication and clinical records. This medication review was assessed and modified by an independent pharmacist reviewers' panel. Outcomes were the number and type of DRPs and recommendations and percentage of clinical relevant DRPs. Clinical relevance of DRPs was assessed by DRPs assigned a high priority, DRPs followed by recommendations for drug change and DRPs followed by implemented recommendations for drug change.
  
  
  RESULTS
  A total of 1565 potential DRPs and recommendations (10 per patient).were identified for 155 patients (median age, 76 years; 54% women). Fifty-eight per cent of all recommendations involved a drug change; 27% of all DRPs were identified during patient interviews and 74% from medication and clinical records. Compared to DRPs identified from patient medication and clinical records, DRPs identified during patient interviews were more frequently assigned a high priority (OR = 1.8 [1.4-2.2]), were more frequently associated with recommendations for drug change (OR = 2.4 [1.9-3.1]) and were implemented recommendations for drug change (OR = 2.8 [2.1-3.7]).
  
  
  CONCLUSIONS
  This study shows that more than a quarter of all DRPs were identified during patient interviews. DRPs identified during patient interviews were more frequently assigned a higher clinical relevance.
authors.affiliation: Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands. h.f.kwint@uu.nl
authors.forename: H F
authors.initials: HF
authors.lastname: Kwint
authors.forename: A
authors.initials: A
authors.lastname: Faber
authors.forename: J
authors.initials: J
authors.lastname: Gussekloo
authors.forename: M L
authors.initials: ML
authors.lastname: Bouvy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003157:Community Pharmacy Services / Q000458:organization & administration; D003430:Cross-Sectional Studies; D017723:Drug Utilization Review / Q000379:methods*; D005260:Female; D006699:Home Care Services / Q000458:organization & administration*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D009426:Netherlands; D010595:Pharmacists / Q000458:organization & administration; D019338:Polypharmacy; D055553:Prescription Drugs / Q000009:adverse effects* / Q000627:therapeutic use; D024382:Professional Role
chemical_list: D055553:Prescription Drugs