title: Markers of pathological excitability derived from principal dynamic modes of hippocampal neurons.
abstract: Transformation of principal dynamic modes (PDMs) under epileptogenic conditions was investigated by computing the Volterra kernels in a rodent epilepsy model derived from a mouse whole hippocampal preparation, where epileptogenesis was induced by altering the concentrations of Mg(2 +) and K(+) of the perfusate for different levels of excitability. Both integrating and differentiating PDMs were present in the neuronal dynamics, and both of them increased in absolute magnitude for increased excitability levels. However, the integrating PDMs dominated at all levels of excitability in terms of their relative contributions to the overall response, whereas the dominant frequency responses of the differentiating PDMs were shifted to higher ranges under epileptogenic conditions, from ripple activities (75-200 Hz) to fast ripple activities (200-500 Hz).
authors.affiliation: Department of Electrical and Computer Engineering, University of Toronto, M5S 3G4 ON, Canada. ellen.kang@mail.utoronto.ca
authors.forename: Eunji E
authors.initials: EE
authors.lastname: Kang
authors.forename: Osbert C
authors.initials: OC
authors.lastname: Zalay
authors.forename: Demitre
authors.initials: D
authors.lastname: Serletis
authors.forename: Peter L
authors.initials: PL
authors.lastname: Carlen
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakjian
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D056004:Molecular Dynamics Simulation; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D009924:Organ Culture Techniques