title: Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones.
abstract: An efficient and organo-catalyzed method has been developed for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2,4-thiazolidinedione 2a/2-thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a-b via addition-elimination reaction. This protocol has the features of use of inexpensive, ecofriendly readily available, effective catalyst system viz. urea/thiourea, avoidance of volatile solvents, excellent yield and simple work-up procedure.
authors.affiliation: Department of Chemistry, Punjabi University, Patiala 147002, Punjab, India. sakshishah29@gmail.com
authors.forename: Sakshi
authors.initials: S
authors.lastname: Shah
authors.forename: Baldev
authors.initials: B
authors.lastname: Singh
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry; D014508:Urea / Q000737:chemistry*
chemical_list: D045162:Thiazolidinediones; D014508:Urea; D013890:Thiourea