title: [Clinical pharmacy and pharmacovigilance over a period of nine years in hospital].
abstract: BACKGROUND
  Underreporting is the main limit in any pharmacovigilance system relying on spontaneous notification. Available data emphasize that pharmacists report few adverse drug reactions (ADRs) in France.
  
  
  OBJECTIVE
  To report how the integration of pharmacists in health care units contributes to reporting of ADRs and to study the validity of the reports.
  
  
  METHODS
  Over a period of nine years we have prospectively collected and analyzed all ADRs collected by pharmacists in a university hospital setting and notified to the regional center of pharmacovigilance.
  
  
  RESULTS
  Over the study period 2017 notifications were sent. Over the past four years the annual number of reports varied between 250 and 350. This amount is approximately ten times the number referred by physicians during the year preceding the beginning of this work. Only 8.6% of the submitted notifications were rejected by the pharmacovigilance center for various reasons: no causal link between the adverse event and taking medication, problem of timing, lack of data...
  
  
  CONCLUSIONS
  The integration of the adverse reaction reporting in the daily activities of the pharmacist is a mean to increase very significantly the number of reports (factor of increase of 9.6 to 13.4).
authors.affiliation: Service Pharmaceutique, Hôpital de la Croix Rousse, Lyon, France.
authors.forename: Marie-Gabrielle
authors.initials: MG
authors.lastname: Guédat
authors.forename: Aurore
authors.initials: A
authors.lastname: Gouraud
authors.forename: Takeswarsing
authors.initials: T
authors.lastname: Ramiah
authors.forename: Jacques
authors.initials: J
authors.lastname: Demazière
authors.forename: Bertrand
authors.initials: B
authors.lastname: Delanoy
authors.forename: Thierry
authors.initials: T
authors.lastname: Vial
authors.forename: Gilles
authors.initials: G
authors.lastname: Leboucher
authors.forename: Bruno
authors.initials: B
authors.lastname: Charpiat
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D004347:Drug Interactions; D005260:Female; D005602:France; D006785:Hospitals, University; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010595:Pharmacists; D010601:Pharmacology, Clinical / Q000639:trends*; D060735:Pharmacovigilance; D010607:Pharmacy Service, Hospital; D015203:Reproducibility of Results; D055815:Young Adult