title: The efficacy of erythrocytes isolated from blood stored under blood bank conditions.
abstract: BACKGROUND
  The RBCs storage lesion is most carefully viewed as the sum of all the changes in RBCs occurring during the course of storage and that limit their survival.
  
  
  METHODS
  Erythrocytes were isolated from stored blood at regular intervals. Oxidative stress markers were analyzed to determine the changes during the storage.
  
  
  RESULTS
  Antioxidant enzymes--(SOD and CAT), and SH showed insignificant variation whereas hemolysis, MDA and AOPP showed significant variations.
  
  
  CONCLUSIONS
  The oxidative stress has not successfully overridden the protection offered by the endogenous antioxidant system. Prolonged storage may result in the onset of erythrocyte deterioration. This clearly indicates that the erythrocytes are capable of attenuating ROS with 2 weeks of storage.
authors.affiliation: Department of Biotechnology, Center for Post Graduate Studies, Jain University, Jayanagar, Bangalore 560 011, India. inav_r@rediffmail.com
authors.forename: Vani
authors.initials: V
authors.lastname: Rajashekharaiah
authors.forename: Abel Abraham
authors.initials: AA
authors.lastname: Koshy
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Koushik
authors.forename: Harsimran
authors.initials: H
authors.lastname: Kaur
authors.forename: Kavita
authors.initials: K
authors.lastname: Kumari
authors.forename: Madhusudan
authors.initials: M
authors.lastname: Agrawal
authors.lastname: Priyanka
authors.lastname: Ramya
authors.forename: Smrutishree
authors.initials: S
authors.lastname: Khatai
authors.forename: Vaishnavi
authors.initials: V
authors.lastname: Gowda
authors.forename: Vinay
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001771:Blood Banks / Q000592:standards*; D001793:Blood Preservation / Q000379:methods*; D004912:Erythrocytes / Q000166:cytology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar