title: Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in comatose survivors of cardiac arrest: characteristics and prognostic value.
abstract: OBJECTIVE
  To analyze the prevalence of stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in patients with coma after cardiac arrest (CA) and therapeutic hypothermia (TH) and to examine their potential association with outcome.
  
  
  METHODS
  We studied our prospective cohort of adult survivors of CA treated with TH, assessing SIRPIDs occurrence and their association with 3-month outcome. Only univariated analyses were performed.
  
  
  RESULTS
  105 patients with coma after CA who underwent electroencephalogram (EEG) during TH and normothermia (NT) were studied. Fifty-nine patients (56%) survived, and 48 (46%) had good neurological recovery. The prevalence of SIRPIDs was 13.3% (14/105 patients), of whom 6 occurred during TH (all died), and 8 in NT (3 survived, 1 with good neurological outcome); none had SIRPIDs at both time-points. SIRPIDs were associated with discontinuous or non-reactive EEG background and were a robustly related to poor neurological outcome (p < 0.001).
  
  
  CONCLUSIONS
  This small series provides preliminary univariate evidence that in patients with coma after CA, SIRPIDs are associated with poor outcome, particularly when occurring during in therapeutic hypothermia. However, survival with good neurological recovery may be observed when SIRPIDs arise in the post-rewarming normothermic phase.
  
  
  CONCLUSIONS
  This study provides clinicians with new information regarding the SIRPIDs prognostic role in patients with coma after cardiac arrest.
authors.affiliation: Department of Clinical Neurosciences, Switzerland.
authors.forename: Vincent
authors.initials: V
authors.lastname: Alvarez
authors.forename: Mauro
authors.initials: M
authors.lastname: Oddo
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003128:Coma / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D012640:Seizures / Q000503:physiopathology*; D016019:Survival Analysis; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D010751:Phosphopyruvate Hydratase