title: Ultrahigh-viscosity hydroxypropylmethylcellulose blunts postprandial glucose after a breakfast meal in women.
abstract: OBJECTIVE
  To determine the effects of two water-soluble dietary fibers, ultrahigh-viscosity hydroxypropylmethylcellulose (UHV-HPMC, nonfermentable) and psyllium fiber (fermentable), on postprandial glucose and second meal effects.
  
  
  METHODS
  In a single-blind crossover design, 12 healthy adult subjects were given standardized, premeasured breakfast and lunch meals with either 4 g of the fiber supplements or a placebo. Blood glucose was measured with a continuous blood glucose monitoring system (DexCom Seven Plus, San Diego, CA).
  
  
  RESULTS
  Subjects consuming UHV-HPMC had significantly (p < 0.05) lower blood glucose area under the curve (AUC) 2 hours after breakfast than those receiving a placebo. Subjects consuming psyllium also tended to have lower glucose levels than the placebo group. Peak glucose concentration following breakfast was significantly (p < 0.01) less with UHV-HPMC when compared with the placebo. No significant differences in AUC or peak glucose concentration between treatments following the second meal (lunch) were detected, suggesting no residual effect from the fiber supplements.
  
  
  CONCLUSIONS
  Supplementation with viscous water-soluble fibers may be an effective means of reducing the glycemic response of a meal in healthy adults.
authors.affiliation: Department of Nutrition, Exercise, and Health Sciences, Central Washington University, 400 University Way, Ellensburg, WA 98926-7572, USA.
authors.forename: Shireen
authors.initials: S
authors.lastname: Dow
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Pritchett
authors.forename: Susan
authors.initials: S
authors.lastname: Hawk
authors.forename: Stefanie J
authors.initials: SJ
authors.lastname: Herrington
authors.forename: David L
authors.initials: DL
authors.lastname: Gee
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D062408:Breakfast; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000008:administration & dosage; D019587:Dietary Supplements; D005260:Female; D005285:Fermentation; D006801:Humans; D065347:Hypromellose Derivatives; D007328:Insulin / Q000097:blood; D062409:Lunch; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019518:Postprandial Period / Q000187:drug effects*; D011620:Psyllium / Q000008:administration & dosage*; D016037:Single-Blind Method; D014783:Viscosity; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D065347:Hypromellose Derivatives; D011620:Psyllium; D008747:Methylcellulose