title: Chiral Brønsted acid catalyzed enantioselective allenylation of aldehydes.
abstract: A versatile and highly enantioselective chiral Brønsted acid-catalyzed allenylation of aldehydes with propargyl borolane is reported. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.
authors.affiliation: Chemical and Analytical Development, Novartis Pharmaceutical Corporation, East Hanover, New Jersey 07936, USA. reddylrajender@yahoo.com
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
mesh_terms: D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D010293:Pargyline / Q000031:analogs & derivatives*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D000447:Aldehydes; D000466:Alkadienes; D001896:Boron Compounds; D010293:Pargyline