title: [Lipodystrophy and echographic hepatic steatosis in HIV-positive patients under highly active antiretroviral therapy (HAART) in Yaounde (Cameroon)].
abstract: The association between sonographic liver steatosis and clinical lipodystrophy in AIDS patients treated by highly active antiretroviral therapy (HAART) has been studied. We conducted a cross-sectional study reviewing medical files of 117 AIDS patients followed up in Yaounde, Cameroon (6.3 F/1 M, mean age = 40 ± 9.4 years), and treated the patients with HAART protocol comprising stavudine or zidovudine for at least six months. All participants underwent abdominal ultrasonography and anthropometric assessment including body mass index (BMI). Data analysis included determining the association between sonographic liver steatosis, clinical lipodystrophy, and other clinical and biological data using the ¢(2) test, and the calculation of odd ratio. Fifty-one patients presented clinical lipodystrophy. The sonographic prevalence of hepatomegaly and splenomegaly was 70.1% and 25.6%, respectively. The overall prevalence of sonographic steatosis was 28.2%; specifically 37.3% among lipodystrophic patients and 21.1% among nonlipodystrophic patients (P = 0.03). According to the type of lipodystrophy, the prevalence was 40.6% among lipohypertrophic patients, 38.5% among lipodystrophic patients, and 16.7% among lipoatrophic patients. Clinical lipohypertrophy was statistically associated with a higher prevalence of sonographic steatosis (odd ratio = 2.5; 95% CI: [1.01-6.39], and P = 0.04). HAART protocol including stavudine was associated with lipodystrophy. The prevalence of sonographic liver steatosis is high among AIDS patients under HAART and is associated with lipohypertrophy.
authors.affiliation: Hôpital central de Yaoundé, Yaoundé, Cameroun, pc.ongolo@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Ongolo-Zogo
authors.forename: N
authors.initials: N
authors.lastname: Nkodo Mbia
authors.forename: T L
authors.initials: TL
authors.lastname: Mvogo Minkala
authors.forename: M
authors.initials: M
authors.lastname: Biwole Sida
authors.forename: C
authors.initials: C
authors.lastname: Kouanfack
authors.forename: S
authors.initials: S
authors.lastname: Nko Amvene
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects* / Q000379:methods; D002163:Cameroon / Q000453:epidemiology; D005234:Fatty Liver / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000453:epidemiology; D015497:HIV-1 / Q000502:physiology; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014463:Ultrasonography; D055815:Young Adult