title: Role of NF-κB in hepatocarcinogenesis and its potential inhibition by dietary antioxidants.
abstract: In this review, the role of nuclear factor-κB (NF-κB) in hepatocarcinogenesis is examined. The administration of several hepatic tumor promoters leads to the activation of NF-κB in the liver of rats and mice. Many studies support the hypothesis that the activation of NF-κB in the liver is inhibited by antioxidants. The role of NF-κB in hepatocarcinogenesis has been examined using NF-κB overexpression and knockout models. The role of NF-κB in liver carcinogenesis is complex; some models show that NF-κB contributes to carcinogenesis whereas others see no effect or an inhibition. Overall, although hepatic tumor promoting agents can activate NF-κB and this activation can be inhibited by antioxidants, the significance of this activation is unclear.
authors.affiliation: Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506-0054, USA. hglauert@uky.edu
authors.forename: Howard Perry
authors.initials: HP
authors.lastname: Glauert
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004032:Diet; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: D000975:Antioxidants; D016328:NF-kappa B