title: Response to antiretroviral therapy in occult hepatitis B and HIV co-infection in West Africa.
abstract: This study evaluated the outcome of first-line antiretroviral therapy among 35 Ghanaians with occult HBV/HIV co-infection, comparing them over 2 years to 120 patients with HBsAg+ HBV/HIV co-infection and 230 patients without HBV co-infection. Increases in CD4 cell count and BMI were similar, whereas elevations of hepatic transaminases were more frequent in both the occult HBV and HBsAg+ patients. Occult HBV/HIV co-infection appears not to impact adversely on response to antiretroviral therapy in Ghana.
authors.affiliation: Centre for Clinical Infection, The James Cook University Hospital, Middlesbrough, UK. davidr.chadwick@stees.nhs.uk
authors.forename: David
authors.initials: D
authors.lastname: Chadwick
authors.forename: Alastair
authors.initials: A
authors.lastname: Stanley
authors.forename: Stephen
authors.initials: S
authors.lastname: Sarfo
authors.forename: Lambert
authors.initials: L
authors.lastname: Appiah
authors.forename: Michael
authors.initials: M
authors.lastname: Ankcorn
authors.forename: Geraldine
authors.initials: G
authors.lastname: Foster
authors.forename: Uli
authors.initials: U
authors.lastname: Schwab
authors.forename: Richard
authors.initials: R
authors.lastname: Phillips
authors.forename: Anna M
authors.initials: AM
authors.lastname: Geretti
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D060085:Coinfection; D018450:Disease Progression; D005260:Female; D005869:Ghana / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D006509:Hepatitis B / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D006514:Hepatitis B Surface Antigens; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine