title: Is the IL-10 promoter polymorphism at position -592 associated with immune system-related diseases?
abstract: Immune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL-10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.
authors.affiliation: Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Mojgan Noroozi
authors.initials: MN
authors.lastname: Karimabad
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Elham
authors.initials: E
authors.lastname: Hakimizadeh
authors.forename: Hassan Yousefi
authors.initials: HY
authors.lastname: Daredori
authors.forename: Mahmood
authors.initials: M
authors.lastname: Nazari
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Derek
authors.initials: D
authors.lastname: Kennedy
mesh_terms: D001249:Asthma / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D007492:Iran; D009103:Multiple Sclerosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D016753:Interleukin-10