title: [Diffusion tensor imaging analyses of white matter at an early stage of first-episode schizophrenia].
abstract: OBJECTIVE
  To explore the roles of diffusion tensor imaging (DTI) of white matter at an early stage of schizophrenia.
  
  
  METHODS
  The participants were 20 first-episode, medication-naïve schizophrenics at an early stage (1 - 6 months) and 20 healthy controls adjusted in gender and age during December 2009 and October 2010. They underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample paired t-test with SPM5 software.
  
  
  RESULTS
  The schizophrenics at an early stage demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI: x = 12, y = 24, z = -10; cluster = 145) and right middle occipital lobe (MNI: x = 36, y = -76, z = -2; cluster = 135).
  
  
  CONCLUSIONS
  The altered white matter DTI in right anterior cingulated and middle occipital lobe may contribute to an early detection of schizophrenia.
authors.affiliation: Department of Psychiatry, Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China.
authors.forename: Qin-ling
authors.initials: QL
authors.lastname: Wei
authors.forename: Yan-xin
authors.initials: YX
authors.lastname: Wang
authors.forename: Zhao-yu
authors.initials: ZY
authors.lastname: Gan
authors.forename: Lei-jun
authors.initials: LJ
authors.lastname: Li
authors.forename: Liang-rong
authors.initials: LR
authors.lastname: Zheng
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Guo
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
authors.forename: Jin-bei
authors.initials: JB
authors.lastname: Zhang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology*; D055815:Young Adult