title: Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: results of a pilot biomonitoring study.
abstract: The developing foetus is thought to be at increased risk from exposure to environmental contaminants; however, developmental exposure data is notably lacking for many contaminants. Moreover, potential regional differences or effect of place of birth on residue levels measured in pregnant women is also unknown. Therefore, as part of a multinational biomonitoring study, 125 primiparous pregnant Canadian women were recruited from five Canadian centres (Vancouver, Calgary, Hamilton, Ottawa, and Halifax). Metals in whole blood and persistent organic pollutants (POPs) in plasma were measured by inductively coupled plasma mass spectrometry (ICPMS) and gas chromatography-mass spectrometry (GCMS), respectively. Of the 125 women recruited to this study, complete data sets were available for 123 of which 103 were Canadian born. Data were analysed by analysis of covariance and linear mixed models using age and body mass index as covariates. The metals cadmium (Cd), cobalt (Co), lead (Pb), nickel (Ni), selenium (Se), and total mercury (Hg) were detected in more than 93% of the samples tested. β-Hexachlorohexane (β-HCH), oxychlordane, trans-nonachlor, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), polybrominated diphenyl ether (PBDE) congeners (PBDE-153, PBDE-47), polychlorinated biphenyl (PCB) congeners (PCB-138, -153, and -180), and the dioxin-like PCB congener PCB-118 were quantified in greater than 70% of the samples tested. Significant differences in the concentrations of Cd, Ni, PCB-153, and p,p'-DDE were found between the centres studied. Furthermore, foreign-born pregnant women had significantly higher concentrations of Cd, β-HCH, PBDE-47, PCB-138, -153, -180, and p,p'-DDE compared to Canadian born pregnant women. Taken together, the data suggest that there are potential regional differences in contaminant body burden and place of birth may also contribute to differences in maternal residue concentrations.
authors.affiliation: Department of Obstetrics & Gynecology, McMaster University, Hamilton, Ontario, Canada. fosterw@mcmaster.ca
authors.forename: Warren G
authors.initials: WG
authors.lastname: Foster
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Cheung
authors.forename: Karelyn
authors.initials: K
authors.lastname: Davis
authors.forename: Gillian
authors.initials: G
authors.lastname: Graves
authors.forename: John
authors.initials: J
authors.lastname: Jarrell
authors.forename: Alain
authors.initials: A
authors.lastname: Leblanc
authors.forename: Chun Lei
authors.initials: CL
authors.lastname: Liang
authors.forename: Tara
authors.initials: T
authors.lastname: Leech
authors.forename: Mark
authors.initials: M
authors.lastname: Walker
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Weber
authors.forename: Jay
authors.initials: J
authors.lastname: Van Oostdam
mesh_terms: D000293:Adolescent; D000328:Adult; D002170:Canada; D002706:Chlordan / Q000031:analogs & derivatives / Q000097:blood; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D019216:Metals, Heavy / Q000097:blood*; D010865:Pilot Projects; D011247:Pregnancy; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D019216:Metals, Heavy; D002706:Chlordan; C008743:oxychlordane; C086401:pentabromodiphenyl ether