title: The analysis of allodynia in patients with idiopathic intracranial hypertension.
abstract: OBJECTIVE
  Allodynia is frequently associated with migraine and other primary headaches. Our aim was to investigate the presence of allodynia and related features in idiopathic intracranial hypertension (IIH), which is a disabling secondary headache disorder.
  
  
  METHODS
  We included 46 IIH patients and analyzed their clinical and laboratory findings retrospectively. Allodynia was assessed using the validated 12-item allodynia symptom checklist (ASC-12), in addition to examining pressure (with von Frey filaments) and brush allodynia.
  
  
  RESULTS
  Allodynia was detected in 23 (50%) of IIH patients with ASC-12 and/or instrumental testing. The most commonly reported location was unilateral V1 distribution. The allodynic symptom profile was similar but milder when compared to 143 migraineurs with ASC-12. Only the aggravation of headache with physical activity emerged as a significant variable associated with allodynia in IIH. Among allodynic patients, only eight had previous migraine diagnosis. After onset of IIH, 20 patients reported migraine-like headache, while only three reported non-migrainous headache. In contrast, 13 of 23 non-allodynic IIH patients had non-migrainous headache features (p = 0.0045).
  
  
  CONCLUSIONS
  Half of the IIH patients reported allodynia, and these allodynic patients had mostly migraine-like headache profiles. Our study suggested that IIH may trigger some common mechanisms with migraine in pain pathways causing allodynia.
authors.affiliation: Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Turkey. esmeekizoglu@yahoo.com
authors.forename: Esme
authors.initials: E
authors.lastname: Ekizoglu
authors.forename: Betul
authors.initials: B
authors.lastname: Baykan
authors.forename: Elif K
authors.initials: EK
authors.lastname: Orhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ertas
mesh_terms: D000328:Adult; D017668:Age of Onset; D015897:Comorbidity; D057210:Delayed Diagnosis; D004388:Dura Mater / Q000503:physiopathology; D042241:Early Diagnosis; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D006930:Hyperalgesia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology; D009475:Neurons, Afferent / Q000502:physiology; D009765:Obesity / Q000453:epidemiology; D010147:Pain Measurement; D010211:Papilledema / Q000209:etiology; D011312:Pressure; D011559:Pseudotumor Cerebri / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D063189:Symptom Assessment; D014110:Touch; D014786:Vision Disorders / Q000209:etiology