title: Endocannabinoid signaling in female reproduction.
abstract: Marijuana is a preparation of the flower, as well as the leaves and seeds, of the plant Cannabis sativa. Marijuana has been used for medicinal and recreational purposes for thousands of years due to its psychoactive effects including euphoria, sedation, and analgesia. Although it has been suspected for decades that marijuana has adverse effects on female fertility, the underlying molecular mechanism was not clear. The discovery of cannabinoid receptors and endocannabinoids has advanced studies if cannabinoid signaling. Since then, numerous studies have been published on cannabinoid signaling in female reproductive events, including preimplantation embryo development, oviductal embryo transport, embryo implantation, placentation, and parturition. This review focuses on various aspects of endocannabinoid signaling in female fertility.
authors.affiliation: Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center,  University of Cincinnati College of Medicine , Cincinnati, Ohio 45229, United States.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Sun
authors.forename: Sudhansu K
authors.initials: SK
authors.lastname: Dey
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D063388:Endocannabinoids / Q000502:physiology*; D005260:Female; D005306:Fertilization / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D063388:Endocannabinoids