title: Previous abortion is a positive predictor for ongoing pregnancy in the next cycle in women with repeated IVF failures.
abstract: Early pregnancy loss is common among women treated with assisted reproduction treatment, but whether it is a prognostic factor for success in subsequent IVF cycles is not well established. The aim of this study was to determine whether a biochemical pregnancy (BP) or spontaneous abortion (SA) affects the pregnancy rates in the following cycle. A retrospective study of 2687 women undergoing 6678 cycles between January 1998 and March 2010 was performed. Ongoing pregnancy rate (PR) per cycle was compared between patients with a pregnancy loss versus a negative β-HCG in their previous cycles. Multivariate analysis of factors affecting ongoing pregnancy rate was performed. BP and/or SA in the first three cycles did not significantly alter the chances to conceive (16.9% patients with BP and/or SA in the previous cycle versus 16.5% patients with no previous pregnancy). From cycle 4 onwards, the presence of a previous abortion (either BP or SA) was associated with better ongoing PR (23.0% versus 11.2%, P<0.001). In conclusion, BP and/or SA in a previous cycle appears to be a positive marker for success in subsequent cycles in patients with repeated IVF failures. These results should be further investigated in this challenging group of patients.
authors.affiliation: IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Tel-Aviv University, Tel-Aviv, Israel. jigalh@hotmail.com
authors.forename: Jigal
authors.initials: J
authors.lastname: Haas
authors.forename: Liat
authors.initials: L
authors.lastname: Lerner-Geva
authors.forename: Gil M
authors.initials: GM
authors.lastname: Yerushalmi
authors.forename: Ettie
authors.initials: E
authors.lastname: Maman
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yinon
authors.forename: Micha
authors.initials: M
authors.lastname: Baum
authors.forename: Ariel
authors.initials: A
authors.lastname: Hourvitz
mesh_terms: D000022:Abortion, Spontaneous / Q000503:physiopathology*; D000046:Academic Medical Centers; D000328:Adult; D015415:Biomarkers; D015331:Cohort Studies; D020964:Embryo Loss / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D007246:Infertility / Q000628:therapy; D007247:Infertility, Female / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D007557:Israel / Q000453:epidemiology; D015999:Multivariate Analysis; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers