title: Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?
abstract: Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro-inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up-regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6-trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti-inflammatory treatment in patients with IBD.
authors.affiliation: Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Fichna
authors.forename: A
authors.initials: A
authors.lastname: Mokrowiecka
authors.forename: A I
authors.initials: AI
authors.lastname: Cygankiewicz
authors.forename: P K
authors.initials: PK
authors.lastname: Zakrzewski
authors.forename: E
authors.initials: E
authors.lastname: Małecka-Panas
authors.forename: A
authors.initials: A
authors.lastname: Janecka
authors.forename: W M
authors.initials: WM
authors.lastname: Krajewska
authors.forename: M A
authors.initials: MA
authors.lastname: Storr
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005765:Gastrointestinal Agents / Q000494:pharmacology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000378:metabolism*; D051379:Mice; D010146:Pain / Q000209:etiology / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013449:Sulfonamides / Q000494:pharmacology; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D005765:Gastrointestinal Agents; C544743:RN 1734; D013449:Sulfonamides; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human; C486576:Trpv4 protein, mouse