title: Wintering in Antarctica: impact on immune response of Indian expeditioners.
abstract: The immune system is one of the major thrust areas in understanding the effects of adverse climatic conditions on human health. Exposure to the Antarctic environment, such as isolation, cold, UV radiations, magnetic field, blizzards, circadian biorhythms, and fear of the unknown, modify various components of the immune system. Members of Antarctic expeditions suffer significant emotional strain as a result of physical isolation and social deprivation. The present study was performed on winter team members of the 28th Indian Scientific Expedition. In this study, different immunological parameters, which mainly include cytokines (TNF-α, IFN-γ, TGF-β, and IL-4), chemokine MIP-1α, immunoglobulins (IgA, IgM and IgG), cortisol and netrin-1, were assayed in sera by ELISA. Results showed that TNF-α and MIP-1α levels were significantly increased in March, May and August while IFN-γ levels were increased in March and May while TGF-β levels showed a significant decrease in March and May. Serum IgA levels were significantly increased during the entire period of the stressful expedition. Therefore, the present study suggests that serum IgA could be a potential biomarker for extreme environmental conditions.
authors.affiliation: Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, Delhi, India.
authors.forename: Anand Prakash
authors.initials: AP
authors.lastname: Yadav
authors.forename: Kamla Prasad
authors.initials: KP
authors.lastname: Mishra
authors.forename: Lilly
authors.initials: L
authors.lastname: Ganju
authors.forename: Shashi Bala
authors.initials: SB
authors.lastname: Singh
mesh_terms: D000328:Adult; D000864:Antarctic Regions / Q000208:ethnology; D015415:Biomarkers / Q000378:metabolism; D002940:Circadian Rhythm / Q000276:immunology; D003081:Cold Climate; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D005101:Expeditions; D005819:Genetic Markers / Q000276:immunology; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D044465:White People / Q000208:ethnology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D005819:Genetic Markers