title: Receptor protein complexes are in control of autophagy.
abstract: In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University Clayton Campus, Victoria, Australia.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Mijaljica
authors.forename: Taras Y
authors.initials: TY
authors.lastname: Nazarko
authors.forename: John H
authors.initials: JH
authors.lastname: Brumell
authors.forename: Wei-Pang
authors.initials: WP
authors.lastname: Huang
authors.forename: Masaaki
authors.initials: M
authors.lastname: Komatsu
authors.forename: Mark
authors.initials: M
authors.lastname: Prescott
authors.forename: Anne
authors.initials: A
authors.lastname: Simonsen
authors.forename: Ai
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klionsky
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Devenish
mesh_terms: D000818:Animals; D001343:Autophagy; D001419:Bacteria / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D046912:Multiprotein Complexes; D011956:Receptors, Cell Surface