title: Taste alteration and impact on quality of life after head and neck radiotherapy.
abstract: BACKGROUND
  Dysgeusia is a relatively common complication of head and neck radiotherapy. The aim of this study was to evaluate taste condition after head and neck radiotherapy and its impact on quality of life.
  
  
  METHODS
  In this cohort study 22 patients with head and neck cancer in Tehran University of Medical Sciences Hospital, were interviewed and examined before and 3 weeks after radiotherapy. Patients were given three consecutive concentrations of sugar, salt, citric acid and quinine sulfate solutions to evaluate their taste sensation by Whole Mouth Technique. EORTC-QLQ-H&N35 questionnaire was used before and after radiotherapy to assess the quality of life. Statistical analysis was done using Wilcoxon Signed Rank Test, Spearman's Coefficient of Correlation, Paired t-test, Multiple Ordinary and Multiple Linear Regressions.
  
  
  RESULTS
  Significant changes were observed in concentrations and intensities of different perceived tastes before and after radiotherapy. All patients had dysgeusia after radiotherapy and 72.2% had total taste loss. Impairment was observed mainly in salt and bitter tastes followed by sour and sweet. Subjective dysgeusia reported by 3/4 of the patients, which was correlated with objective taste disorder in terms of different tastes intensity. Age, sex, radiotherapy fractions, dosage and patients level of education had no significant effects on taste alteration. Quality of life was significantly deteriorated after the occurrence of dysgeusia in both total and partial taste losers. None of the aforementioned factors had significant effects on quality of life.
  
  
  CONCLUSIONS
  Head and neck radiotherapy causes impairment in taste perception, and life quality is influenced by dysgeusia.
authors.affiliation: Oral & Maxillofacial Medicine Department, School of Dentistry, Shahid Beheshti Medical University, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Baharvand
authors.forename: N
authors.initials: N
authors.lastname: ShoalehSaadi
authors.forename: R
authors.initials: R
authors.lastname: Barakian
authors.forename: E Jalali
authors.initials: EJ
authors.lastname: Moghaddam
mesh_terms: D000328:Adult; D000368:Aged; D016371:Cranial Irradiation / Q000009:adverse effects*; D004408:Dysgeusia / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D055815:Young Adult