title: Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment.
abstract: Adequate drug delivery to tumors is hindered by barriers such as degradation and non-specific distribution. Nested incorporation of drug-containing nanoparticles within mesoporous silicon particles (MSVs), carriers rationally designed to enhance tumor transport, was hypothesized to result in pronounced and sustained antitumor efficacy. Paclitaxel (PTX)-containing poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-PCL) polymer micelles were favorably loaded within MSVs, after which drug release was significantly delayed. Antitumor efficacy analyses in mice bearing MDA-MB-468 breast tumors demonstrated significant tumor growth suppression following a single administration. Results highlight effective chemotherapeutic shuttling and site-specific controlled release afforded by MSVs, potentially translating towards improvements in patient outcomes and morbidity.
authors.affiliation: Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX 77030, United States.
authors.forename: Elvin
authors.initials: E
authors.lastname: Blanco
authors.forename: Takafumi
authors.initials: T
authors.lastname: Sangai
authors.forename: Angela
authors.initials: A
authors.lastname: Hsiao
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferrati
authors.forename: Litao
authors.initials: L
authors.lastname: Bai
authors.forename: Xuewu
authors.initials: X
authors.lastname: Liu
authors.forename: Funda
authors.initials: F
authors.lastname: Meric-Bernstam
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D011897:Random Allocation; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles