title: Novel piperazinyl derivatives with anti-hyperalgesic, anti-allodynic and anti-inflammatory activities useful for the treatment of Neuropathic Pain.
abstract: A series of structurally novel compounds possessing 2-phenylpiperazin-1-yl nicotinamide template was synthesized and evaluated for neuropathic pain activity. After the assessment of neurotoxicity and peripheral analgesic activity, the compounds were evaluated in a peripheral neuropathic pain model, the chronic constriction injury (CCI) to assess their antiallodynic and antihyperalgesic potential. Studies carried out to assess the underlying mechanism revealed that the compounds (5 and 6) suppressed the inflammatory component of the neuropathic pain and inhibited oxidative and nitrosative stress.
authors.affiliation: Neuropathic Pain Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Andhra Pradesh, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Sharma
authors.forename: Shraddha Suman
authors.initials: SS
authors.lastname: Dash
authors.forename: Gangadhar
authors.initials: G
authors.lastname: Matharasala
authors.forename: Vanamala
authors.initials: V
authors.lastname: Deekshith
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009437:Neuralgia / Q000188:drug therapy*; D009536:Niacinamide / Q000031:analogs & derivatives*; D010879:Piperazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010879:Piperazines; D009536:Niacinamide