title: How important is glycemic control during coronary artery bypass?
abstract: In summary, poor perioperative glycemic control in patients undergoing CABG is associated with increased morbidity and mortality. Maintaining serum glucose less than or equal to 180 mg/dL in patients with diabetes during CABG reduces morbidity and mortality, lowers the incidence of wound infections, reduces hospital length of stay, and enhances long-term survival. In nondiabetic patients undergoing CABG surgery, maintaining serum glucose less than 180 mg/dL has also resulted in improved perioperative outcomes. More aggressive glycemic control (80-120 mg/dL) provides no added improvement in CABG patients with less than or equal to 3 days of ICU care in the absence of ventilatory support or multiorgan failure. Although the precise value for achieving glycemic control in the perioperative period is the subject of much debate, the benefits of perioperative glycemic control with continuous insulin infusions in patients undergoing CABG is no longer debatable.
authors.affiliation: Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston Medical Center, Boston, MA, USA. harold.lazar@bmc.org
authors.forename: Harold L
authors.initials: HL
authors.lastname: Lazar
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D001026:Coronary Artery Bypass / Q000401:mortality; D003324:Coronary Artery Disease / Q000401:mortality / Q000601:surgery*; D003925:Diabetic Angiopathies / Q000601:surgery*; D004730:Endothelium, Vascular / Q000601:surgery; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D007328:Insulin / Q000627:therapeutic use; D017202:Myocardial Ischemia / Q000601:surgery; D011184:Postoperative Period; D011188:Potassium / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D005947:Glucose; D011188:Potassium