title: Anticancer activity of new (tetrazol-5-yl)methylindole derivatives and their acyclic c-nucleoside analogs.
abstract: New (tetrazol-5-yl)methylindole derivatives were synthesized from 2-phenylindole. Furthermore, the sugar acetyl hydrazones of the tetrazole derivatives as well as their derived acyclic C-nucleoside analogs were prepared. The synthesized compounds were studied for their anticancer activity against human liver carcinoma cell line (HepG2) and the results showed that arylidine substituted tetrazole derivatives 7c and 7d were the most active.
authors.affiliation: Department of Photochemistry, National Research Centre, Cairo, Egypt. adelnassar63@hotmail.com
authors.forename: Wael A
authors.initials: WA
authors.lastname: El-Sayed
authors.forename: Salah M
authors.initials: SM
authors.lastname: El-Kosy
authors.forename: Omar M
authors.initials: OM
authors.lastname: Ali
authors.forename: Hadohm M
authors.initials: HM
authors.lastname: Emselm
authors.forename: Adel A H
authors.initials: AA
authors.lastname: Abdel-Rahman
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D009705:Nucleosides; D013777:Tetrazoles