title: Successful treatment by fibrin glue sealant for pneumothorax with chronic GVHD resistant to autologous blood patch pleurodesis.
abstract: Pneumothorax associated with chronic graft-versus-host disease (cGVHD) after stem cell transplantation is a rare complication. Autologous blood has been used successfully for pleurodesis, which was less toxic than chemical agents. However, when pneumothorax is resistant to pleurodesis, no other procedure is more effective and conservative. Here, we describe a case of myelodysplastic syndromes complicated with cGVHD-related pneumothorax. His pneumothorax has been resistant to pleurodesis using autologous blood and was treated successfully with fibrin glue sealant. In our limited experience, we believe the best success could be achieved when this method is used to treat persistent pneumothorax with cGVHD.
authors.affiliation: The Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Shohei
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kamihara
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ono
authors.forename: Kohichi
authors.initials: K
authors.lastname: Takada
authors.forename: Koji
authors.initials: K
authors.lastname: Miyanishi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Takuro
authors.initials: T
authors.lastname: Obama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miyajima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Watanabe
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higami
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000628:therapy; D001769:Blood; D016026:Bone Marrow Transplantation; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000150:complications; D006801:Humans; D008297:Male; D018700:Pleurodesis; D011030:Pneumothorax / Q000209:etiology / Q000628:therapy*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives