title: [Combined injection of pingyangmycin & dexamethasone for the treatment of maxillofacial and cervical venous malformations].
abstract: OBJECTIVE
  To investigate the therapeutic effect of combined injection of pingyangmycin (PYM) & dexame thasone (DXM) for the treatment of maxillofacial and cervical venous malformations.
  
  
  METHODS
  From August 1995 to October 2008, 116 cases with maxillofacial and cervical venous malformations were retrospectively analyzed. The injection dilute was made with PYM 8 mg, DXM 10 mg and 2% lidocaine 2.0 ml (PYM 2 mg/ml). The PYM diluent 1.0-4.0 ml (including the PYM 2-8 mg) was injected into the tumor according to the patients age, tumor size and location. For children, PYM 2-4 mg was injected for one treatment. The needle should be inserted into tumor perpendicularly or from the edge of tumor. After withdrawing blood, the drug was injected into the tumor slowly. The injection could be repeated every 7-10 days. The clinical signs were recorded; ultrasonography and chest X-ray were performed to evaluate the therapeutic effect.
  
  
  RESULTS
  1-5 treatments of injection were performed in the 116 patients. The tumor shrinked and disappeared after treatment with PYM 2-40 mg and DXM 5-50 mg. The patients were followed up for 3-5 years with no occurrence and complication.
  
  
  CONCLUSIONS
  It's safe, effective and practical to treat maxillofacial and cervical venous malformations by combined injection of PYM and DXM. The cosmetic appearance and function can be preserved at the most.
authors.affiliation: Oral and Maxillofacial Surgery, Changyi People's Hospital, Shandong Province, Changyi 261300, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhai
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Zhai
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002648:Child; D003907:Dexamethasone / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008437:Maxilla; D009333:Neck; D012189:Retrospective Studies; D054079:Vascular Malformations / Q000188:drug therapy*; D014680:Veins / Q000002:abnormalities
chemical_list: D001761:Bleomycin; C025703:bleomycetin; D003907:Dexamethasone