title: Drug nano-domains in spray-dried ibuprofen-silica microspheres.
abstract: Silica microspheres encapsulating ibuprofen in separated domains at the nanometre scale are formed by spray-drying and sol-gel processes. A detailed (1)H and (13)C NMR study of these microspheres shows that ibuprofen molecules are mobile and are interacting through hydrogen bonds with other ibuprofen molecules. (1)H magnetisation exchange NMR experiments were employed to characterize the size of the ibuprofen domains at the nanometre scale. These domains are solely formed by ibuprofen, and their diameters are estimated to be ∼40 nm in agreement with TEM observations. The nature and formation of these particular texture and drug dispersion are discussed.
authors.affiliation: Institut Charles Gerhardt de Montpellier, ICGM-MACS, UMR 5253 CNRS-ENSCM-UM2-UM1, 8 rue de l'Ecole Normale, 34296 Montpellier cedex 5, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Fatnassi
authors.forename: Corine
authors.initials: C
authors.lastname: Tourné-Péteilh
authors.forename: Tzonka
authors.initials: T
authors.lastname: Mineva
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Devoisselle
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaveau
authors.forename: Franck
authors.initials: F
authors.lastname: Fayon
authors.forename: Bruno
authors.initials: B
authors.lastname: Alonso
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008863:Microspheres; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D018712:Analgesics, Non-Narcotic; D004337:Drug Carriers; D012822:Silicon Dioxide; D007052:Ibuprofen