title: [Alpha-dephenzine concentration in peripheral blood of patients diagnosed with schizophrenia].
abstract: Over the past few decades the search for predisposed biological markers has become the course of most priority in scientific psychiatry. Research goal was to reveal the association of alpha-dephenzine concentration in peripheral blood with the disease existence and its progressing (acute and chronic forms) in patients with schizophrenia. In-patients diagnosed with schizophrenia have been investigated (av. age - 45.33±1.86), among them 26 males (av. age - 39.41±1.86) and 13 females (av. age - 45.04±2.44). 27 patients with acute form of schizophrenia (av.age - 44.88±2.42), 12 patients with a chronic form (av. age - 46.33±2.75). 15 healthy volunteers have been investigated as well (av.age - 40.03±2.94), 5 males and 10 females among them. The study of alpha-dephenzine concentration by the immunoenzyme method has been implied in the investigation. Research studies revealed statistically valid increased concentration of alpha-dephenzine in patients diagnosed with schizophrenia comparing with healthy volunteers. The difference was so evident that qualitative difference (marker existence-nonexistence) would rather be considered than quantitative one. Relying on the results of studies we can estimate alpha-dephenzines as possible biomarkers of schizophrenia.
authors.forename: B L
authors.initials: BL
authors.lastname: Bzhalava
authors.forename: Sh G
authors.initials: ShG
authors.lastname: Petriashvili
authors.forename: Z T
authors.initials: ZT
authors.lastname: Gurtskaia
authors.forename: D Z
authors.initials: DZ
authors.lastname: Zurabashvili
authors.forename: N R
authors.initials: NR
authors.lastname: Chikadze
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood* / Q000503:physiopathology; D023084:alpha-Defensins / Q000097:blood*
chemical_list: D015415:Biomarkers; D023084:alpha-Defensins