title: Gamma knife radiosurgery for the treatment of cystic cerebral metastases.
abstract: OBJECTIVE
  To assess the role of Gamma Knife radiosurgery (GKRS) in the treatment of nonsurgical cystic brain metastasis, and to determine predictors of response to GKRS.
  
  
  METHODS
  We reviewed a prospectively maintained database of brain metastases patients treated at our institution between 2006 and 2010. All lesions with a cystic component were identified, and volumetric analysis was done to measure percentage of cystic volume on day of treatment and consecutive follow-up MRI scans. Clinical, radiologic, and dosimetry parameters were reviewed to establish the overall response of cystic metastases to GKRS as well as identify potential predictive factors of response.
  
  
  RESULTS
  A total of 111 lesions in 73 patients were analyzed; 57% of lesions received prior whole-brain radiation therapy (WBRT). Lung carcinoma was the primary cancer in 51% of patients, 10% breast, 10% colorectal, 4% melanoma, and 26% other. Fifty-seven percent of the patients were recursive partitioning analysis class 1, the remainder class 2. Mean target volume was 3.3 mL (range, 0.1-23 mL). Median prescription dose was 21 Gy (range, 15-24 Gy). Local control rates were 91%, 63%, and 37% at 6, 12, and 18 months, respectively. Local control was improved in lung primary and worse in patients with prior WBRT (univariate). Only lung primary predicted local control in multivariate analysis, whereas age and tumor volume did not. Lesions with a large cystic component did not show a poorer response compared with those with a small cystic component.
  
  
  CONCLUSIONS
  This study supports the use of GKRS in the management of nonsurgical cystic metastases, despite a traditionally perceived poorer response. Our local control rates are comparable to a matched cohort of noncystic brain metastases, and therefore the presence of a large cystic component should not deter the use of GKRS. Predictors of response included tumor subtype. Prior WBRT decreased effectiveness of SRS for local control rates.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Julius O
authors.initials: JO
authors.lastname: Ebinu
authors.forename: Shelly
authors.initials: S
authors.lastname: Lwu
authors.forename: Eric
authors.initials: E
authors.lastname: Monsalves
authors.forename: Mandana
authors.initials: M
authors.lastname: Arayee
authors.forename: Caroline
authors.initials: C
authors.lastname: Chung
authors.forename: Normand J
authors.initials: NJ
authors.lastname: Laperriere
authors.forename: Abhaya V
authors.initials: AV
authors.lastname: Kulkarni
authors.forename: Pablo
authors.initials: P
authors.lastname: Goetz
authors.forename: Gelareh
authors.initials: G
authors.lastname: Zadeh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D001943:Breast Neoplasms; D015179:Colorectal Neoplasms; D003560:Cysts / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D015999:Multivariate Analysis; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D047368:Tumor Burden