title: Risk factors for unsuccessful peripheral blood stem cell harvesting using granulocyte-colony stimulating factor mobilization in patients with multiple myeloma.
abstract: The aim of this study was to determine factors that influence unsuccessful peripheral blood stem cell (PBSC) harvesting in patients with multiple myeloma (MM). Retrospective data of 186 MM patients who received G-CSF as mobilization were analyzed. Patients with successful harvest were compared with those who failed (using 2 definitions of failure <2 and <4 CD34 cells×10(6)/mm(3)). The groups were compared regarding age, gender, body weight, baseline platelet count, receipt of radiotherapy, number of prior chemotherapy regimens, PBSC count before collection, processed and collected volume, collect replace, number of sessions and final number of PBSC collected. By multivariate analysis, a baseline platelet count <161,000 cells/mm(3) was associated with PBSC harvest lower than 2×10(6)/kg, and age >58 years was related to PBSC harvest lower than 4×10(6)/kg CD34 cells/kg. Patients with these parameters should not receive mobilization protocols with G-CSF alone. Alternative protocols should be tested in this high risk harvest failure population.
authors.affiliation: Internal Medicine, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Caroline Pinto Rebello
authors.initials: CP
authors.lastname: Lacativa
authors.forename: Paulo Gustavo Sampaio
authors.initials: PG
authors.lastname: Lacativa
authors.forename: Marcia
authors.initials: M
authors.lastname: Garnica
authors.forename: Rodrigo Doyle
authors.initials: RD
authors.lastname: Portugal
authors.forename: Rony
authors.initials: R
authors.lastname: Schaffel
authors.forename: Helio dos Santos
authors.initials: Hdos S
authors.lastname: Dutra
authors.forename: Carmen Martins
authors.initials: CM
authors.lastname: Nogueira
authors.forename: Marcio
authors.initials: M
authors.lastname: Nucci
authors.forename: Angelo
authors.initials: A
authors.lastname: Maiolino
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor