title: Rotavirus infection in children of Nizhny Novgorod, Russia: the gradual change of the virus allele from P[8]-1 to P[8]-3 in the period 1984-2010.
abstract: A collection of rotavirus samples collected over a 26-year period was examined to study the dynamics of change in RV strains of genotype P[8] in a geographically defined population (Nizhny Novgorod, Russia; children under 6 years) with no vaccine pressure. Phylogenetic analysis of gene VP4 (subunit VP8*) showed the presence of two lines of genotype P[8]: P[8]-1 and P[8]-3. Since 1997, the dominant population of rotavirus has been occupied by strains carrying the allele P[8]-3, which is associated with G1, G3 and G4. The complete replacement of the allele P[8]-1 to P[8]-3 took 19 epidemic years.
authors.affiliation: Laboratory of Molecular Epidemiology of Viral Infections, IN Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Novikova
authors.forename: O V
authors.initials: OV
authors.lastname: Morozova
authors.forename: O F
authors.initials: OF
authors.lastname: Fedorova
authors.forename: N V
authors.initials: NV
authors.lastname: Epifanova
authors.forename: T A
authors.initials: TA
authors.lastname: Sashina
authors.forename: E I
authors.initials: EI
authors.lastname: Efimov
mesh_terms: D000483:Alleles; D002648:Child; D058872:Epidemics; D015967:Gene Expression Regulation, Viral; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology*; D012426:Russia / Q000453:epidemiology; D016415:Sequence Alignment; D013997:Time Factors