title: Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy.
abstract: Recent evidence has demonstrated that the existence of a cancer stem cell (CSC) subset in a solid tumor is responsible for the progression and relapse of cancer as well as its resistance to current therapies. Over the past decade, CSC research on pancreatic cancer has progressed. A fundamental understanding of pancreatic CSCs may improve therapies and deepen insight into the role of cell-cell interactions within a tumor microenvironment in pancreatic cancer progression. This review focuses on the impact of pancreatic CSCs on the regulatory networks in the tumor microenvironment, and the implications of targeting CSCs to treat pancreatic cancer.
authors.affiliation: Frontier Science Research Center, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima, 890-8520, Japan. sonshin@m2.kufm.kagoshima-u.ac.jp
authors.forename: Sonshin
authors.initials: S
authors.lastname: Takao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.forename: Shyuichiro
authors.initials: S
authors.lastname: Matsubara
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004273:DNA, Neoplasm / Q000235:genetics*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm