title: Role of thrombomodulin gene in Indian population with coronary artery disease.
abstract: BACKGROUND
  Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker.
  
  
  OBJECTIVE
  To investigate the role of the TM genetic variants and soluble TM (sTM) plasma levels in Indian population with CAD.
  
  
  METHODS
  This case-control study involved genotyping of the entire TM gene and sTM levels estimation in 266 subjects.
  
  
  RESULTS
  None of the four TM genetic variants identified significantly increased CAD risk in the study population. However, further subgroup analysis revealed that in subjects ≤49 years, C1418T variant (Ala455Val substitution) was significantly associated with CAD.
  
  
  CONCLUSIONS
  The increased CAD risk in subjects ≤49 years due to TM Ala455Val substitution is a promising finding. Further validation on large Indian cohorts is required in order to screen asymptomatic young subjects for CAD risk and to establish the clinical utility of Ala455Val substitution.
authors.affiliation: Research Laboratories, P. D. Hinduja National Hospital & Medical Research Centre, Mumbai, India.
authors.forename: Swarup A
authors.initials: SA
authors.lastname: Shah
authors.forename: Tester F
authors.initials: TF
authors.lastname: Ashavaid
authors.forename: Ranjit
authors.initials: R
authors.lastname: Mankeshwar
authors.forename: Chandrashekhar K
authors.initials: CK
authors.lastname: Ponde
authors.forename: Rajesh
authors.initials: R
authors.lastname: Rajani
mesh_terms: D000328:Adult; D000367:Age Factors; D019943:Amino Acid Substitution; D001483:Base Sequence; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA; D018180:Thrombomodulin / Q000097:blood* / Q000235:genetics*
chemical_list: D015415:Biomarkers; D018180:Thrombomodulin