title: Long-term disease-free survival in three ovarian cancer patients with a single relapse.
abstract: Recurrent ovarian cancer with long-term survival is uncommon and often associated with poor prognosis. We report three cases of patients with advanced ovarian cancer who have achieved long-term disease-free survival following a single prior relapse. Case 1 relapsed with a localized bulky tumor and received a complete surgical resection and chemotherapy. Case 2 had a persistent central pelvic tumor after debulking surgery and second-line chemotherapy, and yet achieved excellent control with concurrent chemoradiation to the true pelvis. Case 3 relapsed with paraaortic lymph node metastasis and probable lung metastasis (subsequently negated by positron emission tomography) and received chemotherapy alone. These three patients have since remained disease-free for 13, 12, and seven years, respectively, since their first relapse. We conclude that select patients can obtain long-term disease-free survival after the first relapse by accurate restaging and aggressive multimodality treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: H P
authors.initials: HP
authors.lastname: Chang
authors.forename: K K
authors.initials: KK
authors.lastname: Ng
authors.forename: C C
authors.initials: CC
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Lai
authors.forename: A
authors.initials: A
authors.lastname: Chao
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000556:secondary / Q000628:therapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy*; D010052:Ovariectomy; D011878:Radiotherapy; D058994:Salpingectomy; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents