title: Effect of chronic emotional and pain stress on histone H3 phosphorylation in the hippocampus of rat strains with different excitability of the nervous system.
abstract: Long-term effects of chronic emotional and pain stress on histone H3 phosphorylation by serine 10 in hippocampal CA3 neurons were examined 24 h, 2 weeks, and 2 months after termination of the stress procedure in 2 rat strains differing by excitability of the nervous system. The low excitable rats with high threshold (HT) of excitability were characterized by a high baseline level of histone H3 phosphorylation in comparison with the high excitable rats with low threshold (LT) of excitability. The long-term emotional and pain stress significantly changed the number of positive immune cells in highly excitable rats: this parameter increased in 24 h and 2 weeks after the stress, but returned to the control level in 2 months. In contrast, stress did not affect histone H3 phosphorylation in low excitable rats. Thus, long-term (up to 2 weeks) changes in histone H3 phosphorylation were reveled in rat hippocampal CA3 neurons, which depended on genetically determined functional status of the nervous system.
authors.affiliation: Laboratory of Genetics of Higher Nervous Activity, IP Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. marina.absp@mail.ru
authors.forename: M B
authors.initials: MB
authors.lastname: Pavlova
authors.forename: Yu N
authors.initials: YN
authors.lastname: Savenko
authors.forename: N A
authors.initials: NA
authors.lastname: Dyuzhikova
authors.forename: N V
authors.initials: NV
authors.lastname: Shiryaeva
authors.forename: A I
authors.initials: AI
authors.lastname: Vaido
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D008297:Male; D009420:Nervous System / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology*; D010766:Phosphorylation; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D006657:Histones