title: Incidence of pleural recurrence after computed tomography-guided needle biopsy in stage I lung cancer.
abstract: OBJECTIVE
  A risk of tumor seeding after percutaneous needle biopsy has been reported in various organs, including the lung. This study retrospectively evaluated the proportion of ipsilateral pleural recurrence after computed tomography-guided needle biopsy (CTNB) in p-stage I lung cancer patients.
  
  
  METHODS
  Of the 321 patients diagnosed with p-stage I lung cancer, 124 underwent CTNB before surgery, while 197 underwent non-CTNB procedures, including bronchoscopic biopsy in 188 patients and thoracoscopic wedge resection in 9. These patients were retrospectively analyzed.
  
  
  RESULTS
  While the tumor size was significantly larger in the non-CTNB group (25 ± 9 mm) in comparison to the CTNB group (19 ± 9 mm) (p<0.001), percentage of pleural, vascular, or lymphatic invasions were comparable between the two groups. Eight patients developed ipsilateral pleural recurrences, one (1%) in the CTNB group, and 7 (4%) in the non-CTNB group. Of these, 3 patients developed pleural recurrence only at first, 1 (1%) in the CTNB group, and 2 (1%) in the non-CTNB group. The differences in the proportions of these pleural recurrences between the 2 groups were not significant. Subgroup analyses by baseline characteristics such as tumor size, pT stage, or microscopic pleural invasion, showed that proportions of pleural recurrences in CTNB group were not high compared with non-CTNB group in each subgroup. Analysis of progression-free survival showed that recurrences in CTNB were not high compared with non-CTNB.
  
  
  CONCLUSIONS
  The pleural recurrence was not significantly increased after CTNB in p-stage I lung cancer patients in this particular study.
authors.affiliation: Division of General Thoracic Surgery, Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Asakura
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Yoshikane
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Seishi
authors.initials: S
authors.lastname: Nakatsuka
authors.forename: Masanori
authors.initials: M
authors.lastname: Inoue
authors.forename: Hideki
authors.initials: H
authors.lastname: Yashiro
authors.forename: Takayuki
authors.initials: T
authors.lastname: Abe
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sato
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nomori
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D014057:Tomography, X-Ray Computed