title: Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1).
abstract: The melanin concentrating hormone (MCH) system is a new target to treat human disorders. Our aim was the preparation of the first PET-tracer for the MCHR1. [(11)C]SNAP-7941 is a carbon-11 labeled analog of the published MCHR1 antagonist SNAP-7941. The optimum reaction conditions were 2 min reaction time, ≤25°C reaction temperature, and 2 mg/mL precursor (SNAP-acid) in acetonitrile, using [(11)C]CH(3)OTf as methylation agent. [(11)C]SNAP-7941 was prepared in a reliable and feasible manner with high radiochemical yields (2.9±1.6 GBq; 11.5±6.4% EOB, n=15).
authors.affiliation: Radiochemistry and Biomarker Development Unit, Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Philippe
authors.forename: E
authors.initials: E
authors.lastname: Schirmer
authors.forename: M
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: K
authors.initials: K
authors.lastname: Shanab
authors.forename: R
authors.initials: R
authors.lastname: Lanzenberger
authors.forename: G
authors.initials: G
authors.lastname: Karanikas
authors.forename: H
authors.initials: H
authors.lastname: Spreitzer
authors.forename: H
authors.initials: H
authors.lastname: Viernstein
authors.forename: W
authors.initials: W
authors.lastname: Wadsak
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010880:Piperidines / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography; D011743:Pyrimidines / Q000138:chemical synthesis*; D011786:Quality Control; D017481:Receptors, Somatostatin / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; C491209:Mchr1 protein, mouse; D010880:Piperidines; D011743:Pyrimidines; D017481:Receptors, Somatostatin; C464854:SNAP7941