title: Therapeutic use of omega-3 fatty acids in severe head trauma.
abstract: Traumatic brain injury (TBI) has long been recognized as the leading cause of traumatic death and disability. Tremendous advances in surgical and intensive care unit management of the primary injury, including maintaining adequate oxygenation, controlling intracranial pressure, and ensuring proper cerebral perfusion pressure, have resulted in reduced mortality. However, the secondary injury phase of TBI is a prolonged pathogenic process characterized by neuroinflammation, excitatory amino acids, free radicals, and ion imbalance. There are no approved therapies to directly address these underlying processes. Here, we present a case that was intentionally treated with substantial amounts of omega-3 fatty acids (n-3FA) to provide the nutritional foundation for the brain to begin the healing process following severe TBI. Recent animal research supports the use of n-3FA, and clinical experience suggests that benefits may be possible from substantially and aggressively adding n-3FA to optimize the nutritional foundation of severe TBI patients and must be in place if the brain is to be given the opportunity to repair itself to the best possible extent. Administration early in the course of treatment, in the emergency department or sooner, has the potential to improve outcomes from this potentially devastating public health problem.
authors.affiliation: Brain Health Education and Research Foundation, Arlington, VA, USA. dr.michael.lewis@gmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Lewis
authors.forename: Parviz
authors.initials: P
authors.lastname: Ghassemi
authors.forename: Joseph
authors.initials: J
authors.lastname: Hibbeln
mesh_terms: D000063:Accidents, Traffic; D000293:Adolescent; D001930:Brain Injuries / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D003399:Craniotomy; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005774:Gastrostomy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014140:Tracheotomy
chemical_list: D015525:Fatty Acids, Omega-3