title: Synthesis of homo- and heterofunctionalized glycoclusters and binding to Pseudomonas aeruginosa lectins PA-IL and PA-IIL.
abstract: Homo- and heterofunctionalized glycoclusters with galactose and/or fucose residues targeting both PA-IL and PA-IIL lectins of Pseudomonas aeruginosa were synthesized using "Click" chemistry and DNA chemistry. Their binding to lectins (separately or in a mixture) was studied using a DNA Directed Immobilization carbohydrate microarray. Homoglycoclusters bind selectively to their lectin while the heteroglycocluster binds simultaneously both lectins with a slight lower affinity.
authors.affiliation: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier 1, Université Montpellier 2, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Gerland
authors.forename: Alice
authors.initials: A
authors.lastname: Goudot
authors.forename: Gwladys
authors.initials: G
authors.lastname: Pourceau
authors.forename: Albert
authors.initials: A
authors.lastname: Meyer
authors.forename: Sébastien
authors.initials: S
authors.lastname: Vidal
authors.forename: Eliane
authors.initials: E
authors.lastname: Souteyrand
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: Yann
authors.initials: Y
authors.lastname: Chevolot
authors.forename: François
authors.initials: F
authors.lastname: Morvan
mesh_terms: D057930:Click Chemistry; D005643:Fucose / Q000138:chemical synthesis / Q000737:chemistry*; D005690:Galactose / Q000138:chemical synthesis / Q000737:chemistry*; D037102:Lectins / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000737:chemistry*
chemical_list: D037102:Lectins; D005643:Fucose; D005690:Galactose