title: Signet-ring cell/histiocytoid carcinoma of the eyelid:  a case report and review of the literature.
abstract: Signet-ring cell/histiocytoid carcinomas of the eyelid are rare, slow-growing, and locally aggressive tumors. They predominantly affect elderly men and clinically resemble chronic inflammatory process such as blepharitis and chalazion. To date, the histogenesis of the tumors is still controversial. Only 27 cases of primary signet-ring cell/histiocytoid carcinomas of the eyelid are published in the literature. Local recurrence and distant metastasis occur in 8 and 7 cases, respectively. We report clinical, radiographic, and pathological features of a case of signet-ring cell/histiocytoid carcinoma of the eyelid with review of relevant literature.
authors.affiliation: Department of Pathology, Siriraj Hospital, Mahidol University, Bangkok, Thailand. jtanboon@gmail.com
authors.forename: Jantima
authors.initials: J
authors.lastname: Tanboon
authors.forename: Monkol
authors.initials: M
authors.lastname: Uiprasertkul
authors.forename: Panitee
authors.initials: P
authors.lastname: Luemsamran
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D005260:Female; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor