title: Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types.
abstract: The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
authors.affiliation: Histocompatibility and Immunogenetics Laboratory, Cambridge University Teaching Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. craig.taylor@addenbrookes.nhs.uk
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Taylor
authors.forename: Sarah
authors.initials: S
authors.lastname: Peacock
authors.forename: Afzal N
authors.initials: AN
authors.lastname: Chaudhry
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Bradley
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Bolton
mesh_terms: D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000276:immunology*; D033581:Stem Cell Transplantation / Q000379:methods*; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens