title: One-pot, two-step conversion of aldehydes to phosphonyl- and sulfonylpyrazoles using Bestmann-Ohira reagent.
abstract: A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Deepti
authors.initials: D
authors.lastname: Verma
authors.forename: Shaikh M
authors.initials: SM
authors.lastname: Mobin
authors.forename: Irishi N N
authors.initials: IN
authors.lastname: Namboothiri
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D003500:Cyclization; D007202:Indicators and Reagents; D063065:Organophosphonates / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007202:Indicators and Reagents; D063065:Organophosphonates; D011720:Pyrazoles; D013450:Sulfones