title: Poly(2-oxazoline)s as polymer therapeutics.
abstract: Poly(2-oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next-generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx-based systems were presented, the field lay dormant for almost two decades. Only very recently, POx-based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx-protein conjugates, POx-drug conjugates, POx-based polyplexes and POx micelles for drug delivery.
authors.affiliation: Professur für Makromolekulare Chemie, Department Chemie, Technische Universität Dresden, Dresden, Germany. Robert.Luxenhofer@chemie.tu-dresden.de
authors.forename: Robert
authors.initials: R
authors.lastname: Luxenhofer
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Han
authors.forename: Anita
authors.initials: A
authors.lastname: Schulz
authors.forename: Jing
authors.initials: J
authors.lastname: Tong
authors.forename: Zhijian
authors.initials: Z
authors.lastname: He
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kabanov
authors.forename: Rainer
authors.initials: R
authors.lastname: Jordan
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D008823:Micelles; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D010080:Oxazoles; D004364:Pharmaceutical Preparations; D011108:Polymers; D011506:Proteins; C577913:poly(2-oxazoline)