title: The epidemiology of meningococcal disease in Latin America 1945-2010: an unpredictable and changing landscape.
abstract: Meningococcal disease is mostly endemic in Latin America, with periodic occurrences of outbreaks and epidemics over the last few decades. This literature review summarizes the available epidemiological data for this region between 1945 and 2010. Incidence rates and serogroup distribution differ from country to country and over time. Serogroups A, B, and C have all been major causes of meningococcal disease since the 1970s. In the last decade serogroups W135 and Y may now be emerging in certain countries, with serogroup A virtually disappearing. Although progress has been made in improving and coordinating the surveillance of invasive disease, the uniformity and quality of reported data reflect the fact that the current surveillance systems focus on passive rather than active reporting, hence the reliability of data may vary between countries. Consideration of vaccination policies to control meningococcal disease can only be made with a sufficient understanding of the changing epidemiology in the region.
authors.affiliation: Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.
authors.forename: M A P
authors.initials: MA
authors.lastname: Sáfadi
authors.affiliation: Hospital de Niños Superiora Sor Maria Ludovica, La Plata, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: González-Ayala
authors.affiliation: Heron Evidence Development Ltd, Luton, UK.
authors.forename: A
authors.initials: A
authors.lastname: Jäkel
authors.affiliation: Heron Evidence Development Ltd, Luton, UK.
authors.forename: H
authors.initials: H
authors.lastname: Wieffer
authors.affiliation: GlaxoSmithKline Vaccines, Rio de Janeiro, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Moreno
authors.affiliation: GlaxoSmithKline Vaccines, Wavre, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Vyse
mesh_terms: D002353:Carrier State / Q000453:epidemiology; D018563:Disease Notification; D006291:Health Policy; D006801:Humans; D015994:Incidence; D007843:Latin America / Q000453:epidemiology; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000517:prevention & control; D009345:Neisseria meningitidis; D014611:Vaccination