title: [Study on solid dispersion of binary vector of tanshinone II A].
abstract: OBJECTIVE
  To prepare the solid dispersion of tanshinone II A (TS II A) by the combined application of nano-silica and poloxamer 188 (F68), in order to observe its dissolution and stability.
  
  
  METHODS
  Tanshinone II A solid dispersion was prepared by the solvent method with nano-silica and poloxamer 188 as binary vectors. Its physical characteristics, in vitro dissolution and stability were further assessed.
  
  
  RESULTS
  The tanshinone II solid dispersion was prepared with the weight ratio of nano-silica and poloxamer 188 of 1: 3. The differential scanning calorimetry (DSC) demonstrated that Tanshinone II A existed in vectors as amorphous state. The in vitro dissolution of tanshinone II A solid dispersion is up to 90% at 60 min. Accelerating experiment showed that content and in vitro dissolution of tanshinone II A solid dispersion did not change after storage over 3 months.
  
  
  CONCLUSIONS
  Solid dispersion of binary vector of tanshinone II A can obviously improve the dissolution and stability of tanshinone II in practice.
authors.affiliation: Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. jyanrong03@163.com
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Zhenhai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Tang
authors.forename: Tiantian
authors.initials: T
authors.lastname: Ma
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Jia
mesh_terms: D045784:Abietanes / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D012995:Solubility
chemical_list: D045784:Abietanes; D004365:Drugs, Chinese Herbal; C021751:tanshinone