title: The protective effect of ebselen on radiocontrast-induced nephrotoxicity.
abstract: OBJECTIVE
  Radiocontrast-induced nephropathy has become one of the most important causes of renal acute failure. The most effective management of reducing the incidence of contrast nephropathy is to understand and prevent its causes. We aimed to investigate the protective role of ebselen against radiocontrast-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats.
  
  
  METHODS
  Albino Wistar rats were randomly separated into four groups. The Group 1 rats were treated with sodium chloride as the control group, Group 2 with radiocontrast, Group 3 with radiocontrast plus ebselen, and Group 4 with ebselen alone. After 24 h, the animals over the experimental period were euthanized and blood samples were analyzed for blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Kidney sections were analyzed for malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as histopathological changes.
  
  
  RESULTS
  In the radiocontrast group, BUN, MDA, and GSH-Px levels increased while SOD activity decreased compared with the control group. These decays were improved by ebselen administration in the radiocontrast group. Significant histological deteriorations were observed in the radiocontrast group. We noted improvement in the histologic findings with ebselen administration.
  
  
  CONCLUSIONS
  These results indicate that ebselen might produce a protective mechanism against radiocontrast-induced nephrotoxicity.
authors.affiliation: Department of Pathology, School of Medicine, Mustafa Kemal University, Hatay, Turkey. ozgurtumay@yahoo.com
authors.forename: Tumay
authors.initials: T
authors.lastname: Ozgur
authors.forename: Murat
authors.initials: M
authors.lastname: Tutanc
authors.forename: Ismail
authors.initials: I
authors.lastname: Zararsiz
authors.forename: Sedat
authors.initials: S
authors.lastname: Motor
authors.forename: Oktay Hasan
authors.initials: OH
authors.lastname: Ozturk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaldiz
authors.forename: Ozgur Yildirim
authors.initials: OY
authors.lastname: Kurtgoz
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001393:Azoles / Q000494:pharmacology* / Q000627:therapeutic use; D003287:Contrast Media / Q000009:adverse effects*; D054833:Isoindoles; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D016566:Organoselenium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001393:Azoles; D003287:Contrast Media; D054833:Isoindoles; D016566:Organoselenium Compounds; D017392:Thiobarbituric Acid Reactive Substances; C042986:ebselen; D013482:Superoxide Dismutase