title: A second hit for TMA.
abstract: In this issue of Blood, Fuchs and colleagues provide evidence that circulating DNA and histones, presumably released from neutrophils, would be the second hit for development of thrombotic microangiopathies (TMAs), a group of life-threatening disorders characterized by thrombi in the microvasculature resulting in thrombocytopenia, microangiopathic hemolysis, and organ dysfunction.
authors.affiliation: National Cerebral and Cardiovascular Center.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miyata
authors.forename: Xinping
authors.initials: X
authors.lastname: Fan
mesh_terms: D004247:DNA / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009195:Peroxidase / Q000097:blood*; D057049:Thrombotic Microangiopathies / Q000097:blood* / Q000175:diagnosis*
chemical_list: D004247:DNA; D009195:Peroxidase