title: Birth month and longevity - monthly birth distribution in acute coronary events provoked by atherothrombosis in patients treated with percutaneous coronary intervention (PCI).
abstract: BACKGROUND
  Human homeostasis is time related. Environmental physical factors also play a role. Recent studies published by the National Academy of Sciences (USA) describe human longevity links with the month of birth. The aim of this study was to check monthly birth distribution in patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) related to atherothrombosis - one of the main causes of morbidity and mortality in the industrial world.
  
  
  METHODS
  A total of 4732 (3594 men) subjects were included in the study. Patients treated with PCI for AMI in the years 2000 to March 2010 were studied. The population registry specific to 1950 excluded 1024 patients, i.e., those registered as born on January 1 and they were replaced with patients with an average of births from January 2 to 31. A total of 3675 patients were finally studied (2839 men, 836 women).
  
  
  RESULTS
  The average monthly birth number was 306±60.38. Significant monthly differences in birth number (q2=21.077, p<0.03) were observed. A higher birth rate in the first four months of the year was revealed, with the exception of February. The number of births in these months exceeded the following two four-month data (q2=20.57, p<0.024). March births exceeded the monthly average by more than two standard deviations (SD) - 462, with an analogical increase for both genders. In May-December births were below average.
  
  
  CONCLUSIONS
  Patients with AMI treated with PCI show differences in the month of birth with the majority being born in the first four months of the year and of those most were born in March. Possible implications on pathogenetic clues of atherothrombosis can be assumed.
authors.affiliation: Rabin Medical Center, Petah Tiqwa, Israel. stoupel@inter.net.il
authors.forename: Elyiahu
authors.initials: E
authors.lastname: Stoupel
authors.forename: Evgeny
authors.initials: E
authors.lastname: Abramson
authors.forename: Peter
authors.initials: P
authors.lastname: Israelevich
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Sulkes
mesh_terms: D000367:Age Factors; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000401:mortality; D002340:Carotid Artery Diseases / Q000150:complications / Q000401:mortality / Q000628:therapy*; D003328:Coronary Thrombosis / Q000150:complications / Q000401:mortality / Q000628:therapy*; D005260:Female; D006801:Humans; D007557:Israel; D008136:Longevity; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000401:mortality / Q000628:therapy*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome