title: Accuracy of HistoScanning™ for the prediction of a negative surgical margin in patients undergoing radical prostatectomy.
abstract: OBJECTIVE
  To assess the accuracy of HistoScanning™ (HS) as a visualization tool for preoperative treatment planning for nerve-sparing (NS) radical prostatectomy (RP).
  
  
  METHODS
  A retrospective study was carried out on 80 patients with prostate cancer undergoing RP from October 2009 to December 2009. All patients underwent a HS procedure 1 day before surgery. Frozen sections (FSs) were performed on each latero-posterior side of the prostate to assess for the presence of cancer. On the HS analysis, the region corresponding to that removed at FS was assessed for suspicious lesions. The size of suspicious lesions within this volume was compared with the FS histopathological analysis.
  
  
  RESULTS
  HS results corresponded to a 93% probability of having a negative surgical margin in the FSs. The presence of a HS volume ≥0.2 mL in a specific side was associated with a 3.7 times increased risk of a positive surgical margin at FS.
  
  
  CONCLUSIONS
  HS has the potential to assist in the planning of NSRP. Larger, multicentre studies need to be performed for validation of these encouraging results.
authors.affiliation: Martini-Clinic, Prostate Cancer Center, University Medical Center Eppendorf, Hamburg, Germany. gsalomon@uke.de
authors.forename: Georg
authors.initials: G
authors.lastname: Salomon
authors.forename: Jan
authors.initials: J
authors.lastname: Spethmann
authors.forename: Ann
authors.initials: A
authors.lastname: Beckmann
authors.forename: Philippe
authors.initials: P
authors.lastname: Autier
authors.forename: Caroline
authors.initials: C
authors.lastname: Moore
authors.forename: Leopold
authors.initials: L
authors.lastname: Durner
authors.forename: Mareike
authors.initials: M
authors.lastname: Sandmann
authors.forename: Alexander
authors.initials: A
authors.lastname: Haese
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Uwe
authors.initials: U
authors.lastname: Michl
authors.forename: Hans
authors.initials: H
authors.lastname: Heinzer
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Thomas
authors.initials: T
authors.lastname: Steuber
mesh_terms: D000368:Aged; D005629:Frozen Sections / Q000379:methods / Q000592:standards; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D059351:Organ Sparing Treatments / Q000379:methods; D010347:Patient Care Planning; D011300:Preoperative Care / Q000379:methods; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D020196:Trauma, Nervous System / Q000517:prevention & control; D047368:Tumor Burden; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen