title: Aneurysmal subarachnoid hemorrhage in patients under 35-years-old: a single-center experience.
abstract: OBJECTIVE
  Aneurysmal subarachnoid hemorrhage (SAH) is relatively uncommon in young adults. There is a paucity of data pertaining to the management of aneurysmal SAH in young patients, especially with endovascular therapy.
  
  
  METHODS
  We reviewed all SAH patients under the age of 35 years treated at Jefferson Hospital for Neuroscience, Philadelphia, USA, from 2004 to 2009.
  
  
  RESULTS
  A total of 40 patients (15 males and 25 females) under the age of 35 were treated for aneurysmal SAH. The average patient age was 30 years (17-35 yo); 25 (62.5%) were smokers. Seventeen patients presented with a Hunt and Hess Grade I or II (42.5%), 20 with a Grade III (50%), and 3 with a Grade IV (7.5%). Thirty-two aneurysms (80%) were located in the anterior circulation and 8 (20%) in the posterior circulation. Thirty-five patients (87.5%) were treated with coil embolization versus 5 with craniotomy and clipping. The endovascular and microsurgical occlusion rates were 90.6% and 100%, respectively. There were no procedural complications with endovascular therapy. Of 35 patients undergoing endovascular treatment, 24 (68.6%) had excellent outcomes at time of discharge with a Glasgow outcome scale of 5. There were no deaths in the series. No patient experienced a rehemorrhage after endovascular treatment.
  
  
  CONCLUSIONS
  Smoking, female sex, and anterior circulation aneurysms are highly prevalent in young adults with SAH. Endovascular treatment resulted in an overall favorable outcome with no rehemorrhages in patients under the age of 35 years. Our results suggest that endovascular therapy is a reasonable treatment for young patients with SAH.
authors.affiliation: Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, United States.
authors.forename: Nohra
authors.initials: N
authors.lastname: Chalouhi
authors.forename: Sonia
authors.initials: S
authors.lastname: Teufack
authors.forename: Sid
authors.initials: S
authors.lastname: Chandela
authors.forename: Richard
authors.initials: R
authors.lastname: Dalyai
authors.forename: Stavropoula
authors.initials: S
authors.lastname: Tjoumakaris
authors.forename: David M
authors.initials: DM
authors.lastname: Hasan
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Dumont
authors.forename: L Fernando
authors.initials: LF
authors.lastname: Gonzalez
authors.forename: Robert H
authors.initials: RH
authors.lastname: Rosenwasser
authors.forename: Pascal M
authors.initials: PM
authors.lastname: Jabbour
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002533:Cerebral Angiography; D016208:Databases, Factual; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D008297:Male; D009460:Neurologic Examination; D011446:Prospective Studies; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D015607:Stents; D013345:Subarachnoid Hemorrhage / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult