title: Vaginal delivery and continuous epidural analgesia: should we change our clinical approach?
abstract: The aim of the study was to investigate the effects of continuous epidural analgesia (EA) on the course of vaginal delivery with an emphasis on duration of labor and instrumental interventions. In a prospective 2-year trial, the study group included singleton vaginal births between 35 and 41 gestational weeks with a vertex fetus, in which continuous EA with bupivacaine or chirocaine in concentration of 0.125% combined with 2-4 microg of fentanyl or 0.5 microg of sufenta was used. The control group was created randomly from laboring patients with singleton pregnancies but without EA. The groups were adjusted for epidemiological characteristics and compared regarding the obstetric data and perinatal outcome. Student t-test and Mann-Whitney U-test were performed for normally and non-normally distributed results, respectively. Out of 1284 patients, 551 pregnant women were included in the study group and 733 in the control group. The statistically significant differences between the groups related to duration of the first and second stage of labor, frequency of premature rupture of membranes, intrapartal complications, and incidence of operative deliveries were found. Both stages of labor were significantly protracted and the incidence of operative deliveries was higher in the study group of patients compared with controls. There is a need for an active obstetric approach and management of vaginal deliveries of women who receive continuous EA, particularly if it is medically indicated.
authors.affiliation: University of Rijeka, Rijeka University Hospital Center, Department of Gynecology and Obstetrics, Perinatology Unit, Rijeka, Croatia.
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Sindik
authors.forename: Oleg
authors.initials: O
authors.lastname: Petrović
authors.forename: Marinka
authors.initials: M
authors.lastname: Manestar
authors.forename: Vedran
authors.initials: V
authors.lastname: Francisković
authors.forename: Marko
authors.initials: M
authors.lastname: Klarić
authors.forename: Marinko
authors.initials: M
authors.lastname: Marić
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods* / Q000706:statistics & numerical data; D016362:Analgesia, Obstetrical / Q000379:methods* / Q000706:statistics & numerical data; D036861:Delivery, Obstetric / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D007744:Obstetric Labor Complications / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D011446:Prospective Studies; D014621:Vagina; D055815:Young Adult