title: Facile, selective, and regiocontrolled synthesis of oxazolines and oxazoles mediated by ZnI2 and FeCl3.
abstract: An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI(2) and FeCl(3) is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Gopal Chandru
authors.initials: GC
authors.lastname: Senadi
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Jia-Shing
authors.initials: JS
authors.lastname: Hsiao
authors.forename: Jaya Kishore
authors.initials: JK
authors.lastname: Vandavasi
authors.forename: Chung-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Jeh-Jeng
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; D007454:Iodides; D058116:Lewis Acids; D010080:Oxazoles; D017967:Zinc Compounds; C029770:zinc iodide; C024555:ferric chloride