title: The role of platelets in the treatment of Achilles tendon injuries.
abstract: To systematically review the current in-vivo evidence for the use of platelet-concentrates (PRP) in the treatment of Achilles tendinopathy and Achilles tendon ruptures in animal models and human applications. A systematic search of PubMed, CINAHL, EMBASE, CCTR, and CDSR was performed for animal and human studies on the effect of platelet-concentrates in the treatment of Achilles tendinopathy and ruptures using the terms "Achilles tendon and platelet." The systematic search revealed a total of 149 papers. After excluding duplicates and cases of overlapping data, studies not focusing on in vivo evidence in terms of treatment or outcome, studies without any intervention, studies with unacceptable high attrition, one Chinese and one Swedish study, the remaining 14 manuscripts were included. The key finding of our study is evidence in support of a statistically significant effect of platelet concentrates in the treatment of Achilles tendon ruptures in vivo in animal models and human application, consistent with a medium to large sized effect. This effect is most likely attributable to fastened and enhanced scar tissue maturation. There was no evidence for a beneficial effect of platelets in Achilles tendinopathy.
authors.affiliation: Department of Orthopaedic Surgery, Medical University Graz, Graz, Austria.
authors.forename: Patrick
authors.initials: P
authors.lastname: Sadoghi
authors.forename: Claudio
authors.initials: C
authors.lastname: Rosso
authors.forename: Victor
authors.initials: V
authors.lastname: Valderrabano
authors.forename: Andreas
authors.initials: A
authors.lastname: Leithner
authors.forename: Patrick
authors.initials: P
authors.lastname: Vavken
mesh_terms: D000125:Achilles Tendon / Q000293:injuries*; D000818:Animals; D019317:Evidence-Based Medicine; D006801:Humans; D017713:Platelet Transfusion; D053657:Platelet-Rich Plasma; D013708:Tendon Injuries / Q000628:therapy*