title: Autoinflammatory diseases: how to put the fire inside the body out?
abstract: Autoinflammatory diseases (AIDs) are a group of distinct hereditable disorders characterized by unexplained, recurrent episodes of fever and severe inflammation, most commonly involving skin, joints, gut, and eyes. Mutations in inflammasome-related proteins, particularly in NOD-like receptor (NLR) genes, have been strongly associated with the occurrence of AIDs. However, new genes and dysfunctional proteins have recently been identified and the spectrum of AIDs is ever-expanding. In fact, it has been suggested to encompass other disorders which share some clinical features with AIDs, but are not clearly familial, or are not characterized by fever as a prominent symptom, or are polygenic. In this issue of Autoimmunity Reviews some novel and burning aspects of AIDs were covered and the relationship between AIDs and autoimmune diseases was discussed.
authors.affiliation: Division of Rheumatology, Department of Medicine, University of Padova, Padova, Italy. adoria@unipd.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dayer
authors.forename: Leonardo
authors.initials: L
authors.lastname: Punzi
mesh_terms: D056660:Hereditary Autoinflammatory Diseases / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology; D009154:Mutation; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000276:immunology
chemical_list: D058847:Inflammasomes; D018160:Receptors, Cytoplasmic and Nuclear