title: [Study on the diagnostic value of whole-organ magnetic resonance imaging score (WORMS) in knee osteoarthritis].
abstract: OBJECTIVE
  To explore the diagnostic value of whole-organ magnetic resonance imaging score (WORMS) in knee osteoarthritis (KOA).
  
  
  METHODS
  From November 2009 to January 2011,70 patients with KOA combined with knee effusion among outpatient and inpatient were analyzed retrospectively. Among the patients, 12 patients were male, 58 patients were female,ranging in age from 46 to 75 years,with a mean age of (59.66 +/- 9.93) years. The clinical symptoms were evaluated by WOMAC, the imaging of KOA was assessed by K-L score and WORMS, and COMP and CTX- II were measured respectively by ELISA. The correlation analyses and multiple linear regression analysis were studied to determine associations among biomarkers, clinical variables and radiographic findings of knee joints.
  
  
  RESULTS
  The average scores of WOMAC and WORMS were (57.50 +/- 8.20) and (64.54 +/- 16.45) respectively. The median of CTX- II nd COMP were 2.42 ng/ml and 4.56 ng/ml respectively. Grouped by less than the lowest quartile and more than the highest quartile of WORMS, COMP was significantly different (Z=2.04, P=0.039), but there was no significant difference in CTX-II (Z=0.79, P=0.427). WORMS were positively correlated with WOMAC and K-L score (r=0.777, P<0.01; r=0.716, P<0.01; respectively); WOMAC was also positively correlated with K-L score (r=0.692, P<0.01). WORMS's cartilage, osteophytes and synovitis were positively correlated with WOMAC, K-L score and COMP respectively (r=0.771, P<0.01; r=0.509, P<0.01; r=0.917, P<0.01). It was determined by stepwise regression that the KOA was mainly affected by WORMS, K-L score (P=0.015, P=0.025 respectively) when WOMAC as a dependent variable, age, gender, K-L score, WORMS, COMP and CTX- II as independent variables (F=20.327, P<0.01).
  
  
  CONCLUSIONS
  WORMS has a better reference value for diagnosis of KOA. The expression of COMP is high in the synovial fluid when WORMS at the high point. The clinical symptoms of knee osteoarthritis are mainly affected by WORMS and K-L score.
authors.affiliation: Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Xue-Zong
authors.initials: XZ
authors.lastname: Wang
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Zheng
authors.forename: Yue-long
authors.initials: YL
authors.lastname: Cao
authors.forename: Xin-Feng
authors.initials: XF
authors.lastname: Gu
authors.forename: Song-Pu
authors.initials: SP
authors.lastname: Wei
authors.forename: Ning-yang
authors.initials: NY
authors.lastname: Gao
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Pang
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Zhan
mesh_terms: D000368:Aged; D064236:Cartilage Oligomeric Matrix Protein; D024042:Collagen Type I / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D010455:Peptides / Q000032:analysis
chemical_list: D064236:Cartilage Oligomeric Matrix Protein; D024042:Collagen Type I; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010455:Peptides; C577553:TSP5 protein, human; C052929:collagen type I trimeric cross-linked peptide