title: Tyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cells.
abstract: Chemokines regulate T cell trafficking into secondary lymphoid organs and migration across endothelial cells in response to inflammatory signals. The small guanosine triphosphatase Rap1 is a critical regulator of chemokine signaling in T cells, but how chemokines activate Rap1 has been unclear. A study showed that Abl family tyrosine kinases were essential for chemokine-induced Rap1 activation, T cell polarization, and migration. Abl family kinases promoted Rap1 activation by phosphorylating the adaptor protein human enhancer of filamentation 1 (HEF1), thus establishing a critical Abl-HEF1-Rap1 signaling axis for chemokine-induced T cell migration.
authors.affiliation: Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA. laurent.malherbe@bcw.edu
authors.forename: Laurent P
authors.initials: LP
authors.lastname: Malherbe
authors.forename: Demin
authors.initials: D
authors.lastname: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D002465:Cell Movement / Q000276:immunology*; D018925:Chemokines / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D018448:Models, Immunological; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D020827:rap1 GTP-Binding Proteins / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018925:Chemokines; C099942:NEDD9 protein, human; D010750:Phosphoproteins; C426236:ARG tyrosine kinase; D011505:Protein-Tyrosine Kinases; D020827:rap1 GTP-Binding Proteins