title: Effect of enteral feeding with ginger extract in acute respiratory distress syndrome.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the effects of an enteral diet enriched with ginger extract on inflammatory factors, respiratory profile, and outcome of patients with acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  Thirty-two patients with ARDS were randomized to receive a high-protein enteral diet enriched with ginger or placebo. Serum levels of interleukin (IL) 1, IL-6, tumor necrosis factor α, and leukotriene B4; red blood cell glutathione; oxygenation; and static compliance were measured on days 0, 5, and 10.
  
  
  RESULTS
  Patients fed enteral diet enriched with ginger had significantly lower serum levels of IL-1, IL-6, and tumor necrosis factor α and higher level of RBC glutathione on days 5 and 10 compared with control group (P < .05). Significant improvement in oxygenation was observed on day 5 (P = .02) and 10 (P = .003) in ginger group compared with control group. Static compliance was increased on day 5 (P = .01) in ginger group compared with control group. A significant difference was found in duration of mechanical ventilation (P = .02) and length of intensive care unit stay (P = .04) in favor of ginger group. We did not find any difference in barotraumas, organ failure, and mortality between the study groups.
  
  
  CONCLUSIONS
  An enteral diet supplemented with ginger in patients with ARDS may be beneficial for gas exchange and could decrease duration of mechanical ventilation and length of stay in intensive care unit.
authors.affiliation: National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Science, Tehran, Iran. nutritiondata@yahoo.com
authors.forename: Zahra
authors.initials: Z
authors.lastname: Vahdat Shariatpanahi
authors.forename: Majid
authors.initials: M
authors.lastname: Mokhtari
authors.forename: Fourogh Azam
authors.initials: FA
authors.lastname: Taleban
authors.forename: Farhad
authors.initials: F
authors.lastname: Alavi
authors.forename: Mohamad Hossin
authors.initials: MH
authors.lastname: Salehi Surmaghi
authors.forename: Yadolah
authors.initials: Y
authors.lastname: Mehrabi
authors.forename: Shaahin
authors.initials: S
authors.lastname: Shahbazi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D020939:Zingiber officinale; D005978:Glutathione / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy*; D012129:Respiratory Function Tests; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D010936:Plant Extracts; D005978:Glutathione