title: Continuous multiple liquid-liquid separation: diazotization of amino acids in flow.
abstract: A second-generation laboratory-scale, modular liquid-liquid separation device based on computer-controlled high-pressure pumps and a high-resolution digital camera has been invented. The diazotization of amino acids to produce valuable chiral hydroxyacids is demonstrated in flow for the first time. The use of a triple-separator system in conjuction with the developed diazotization process allows the safe and efficient production and automated isolation of multigram quantities of valuable chiral hydroxyacids.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB21EW, United Kingdon.
authors.forename: Dennis X
authors.initials: DX
authors.lastname: Hu
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Brien
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D006880:Hydroxy Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D006880:Hydroxy Acids