title: Effect of spinal anesthesia for elective cesarean section on cerebral blood oxygenation changes: comparison of hyperbaric and isobaric bupivacaine.
abstract: We used near-infrared spectroscopy (NIRS) to evaluate cerebral blood oxygenation changes in subjects undergoing cesarean section under spinal anesthesia (SP) with hyperbaric bupivacaine (group H, 27 subjects) or isobaric bupivacaine (group I, 15 subjects). In group H, total-Hb, oxy-Hb, and mean blood pressure (MBP) within 20 min after SP were significantly lower than the baseline values. In contrast, there was no significant change from baseline in total-Hb, oxy-Hb, or MBP in group I after SP. Total-Hb and MBP in group H were significantly lower than those in group I within 10 min after SP. There was no significant change of deoxy-Hb, tissue oxygen index, or heart rate from baseline in either of the groups. These results suggest that isobaric bupivacaine may be superior to hyperbaric bupivacaine for preventing a decrease of maternal cerebral blood flow after SP for cesarean section.
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1, Oyaguchi-Kamicho, Itabashi-Ku, Tokyo, 173-8610, Japan. yk-mikan@d8.dion.ne.jp.|Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan. yk-mikan@d8.dion.ne.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kondo
authors.affiliation: Division of Optical Brain Engineering, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakatani
authors.affiliation: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Noriya
authors.initials: N
authors.lastname: Hirose
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1, Oyaguchi-Kamicho, Itabashi-Ku, Tokyo, 173-8610, Japan.|Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Jitsu
authors.initials: J
authors.lastname: Kato
authors.affiliation: Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Setsuro
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, 30-1, Oyaguchi-Kamicho, Itabashi-Ku, Tokyo, 173-8610, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000008:administration & dosage; D062186:Arterial Pressure; D002045:Bupivacaine / Q000008:administration & dosage*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007278:Injections, Spinal; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000779:Anesthetics, Local; D006454:Hemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen; D002045:Bupivacaine