title: Plasmacytoid variant of urothelial carcinoma: a report of a rare case.
abstract: Plasmacytoid variant of urothelial bladder carcinoma is rare. We report a case with a detailed discussion of features that help characterize this variant. A 50-year-old man originally presented with gross hematuria. Resections at that time revealed a grade I-II superficial urothelial carcinoma. He did not return for follow-up until recently, three years later, when he presented with recurrent gross hematuria. An extensive tumor was identified on cystoscopy. Resection revealed a high-grade non-invasive papillary urothelial carcinoma. CT scan revealed a large urinary bladder solid mass with bilateral hydronephrosis. Metastatic workup was negative. The patient underwent a radical cystectomy with creation of ileal conduit. Final pathology revealed plasmacytoid variant of urothelial carcinoma with extensive vascular invasion and extension to the perivesical adipose tissue. We present a rare variant of urothelial carcinoma with comprehensive analysis of the morphological and immunophenotypic clues that characterize this variant.
authors.affiliation: Northern Ontario School of Medicine, Department of Pathology and Laboratory, Medicine, Health Sciences North, Sudbury, Ontario, Canada. Eldemeld@gmail.com
authors.forename: Dina El
authors.initials: DE
authors.lastname: Demellawy
authors.forename: Abdalla D
authors.initials: AD
authors.lastname: Ahmed
authors.forename: Bishwajit
authors.initials: B
authors.lastname: Bora
authors.forename: Michel
authors.initials: M
authors.lastname: Bonin
mesh_terms: D002291:Carcinoma, Papillary / Q000473:pathology* / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000628:therapy; D015653:Cystectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary; D010954:Plasmacytoma / Q000473:pathology* / Q000601:surgery; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy; D019459:Urothelium / Q000473:pathology*