title: Might cigarettes be a "smoking gun" to reduce taxane myelotoxicity?
abstract: de Graan and colleagues report a retrospective study of the effects of cigarette smoking on taxane pharmacokinetics and myelosuppression. There was no difference in taxane pharmacokinetic clearance between smokers and nonsmokers. Further prospective studies of the effects of cigarette smoking on myelosuppression would be of interest.
authors.affiliation: Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. lionel.lewis@dartmouth.edu
authors.forename: Lionel D
authors.initials: LD
authors.lastname: Lewis
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Ratain
mesh_terms: D014408:Biomarkers, Tumor; D017322:Clinical Trials, Phase II as Topic / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor