title: Reliability of plasma D-dimers for predicting severe neurological decompression sickness in scuba divers.
abstract: BACKGROUND
  A low-grade process of coagulation activation in association with severe neurological decompression sickness (DCS) in divers has been anecdotally observed. We aimed to investigate whether measurement of plasma D-dimers and other hemostatic parameters in injured scuba divers were effective as prognostic biomarkers of neurological DCS, and we compared the diagnostic accuracy of a combination of D-dimers test and initial clinical assessment with either one alone.
  
  
  METHODS
  Eligible for the study were 84 recreational divers (69 men, 46 +/- 10 yr; 15 women, 44 +/- 8 yr) referred for neurological DCS in 2007-2011 and treated with hyperbaric oxygen. Blood tests were collected for D-dimers, fibrinogen, and platelet count with a time interval less than 8 h upon admission. Presentation severity was rated numerically for the acute event with a validated scoring system and clinical outcome was assessed by a follow-up examination at 3 mo. Indices of accuracy for D-dimers test, initial clinical score, and combination were estimated.
  
  
  RESULTS
  Incomplete recovery was reported in 26% of patients with a definite relationship between elevated D-dimers and presence of sequelae after multivariate analysis. We did not find differences for other blood coagulation variables between outcome groups. Combination of positive D-dimers (cut-off value of 0.40 microg x ml(-1)) with severe initial presentation attained a higher diagnostic accuracy than either method alone (post-test probabilities = 100%, 86%, and 57%, respectively).
  
  
  CONCLUSIONS
  This study suggests that determination of plasma D-dimers, a marker of activation coagulation, improve the prognostication of neurological DCS affecting scuba divers when combined with presenting severity score.
authors.affiliation: Department of Hyperbaric and Diving Medicine, Sainte Anne's Military Hospital, France. gempp@voila.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gempp
authors.forename: Jean
authors.initials: J
authors.lastname: Morin
authors.forename: Pierre
authors.initials: P
authors.lastname: Louge
authors.forename: Jean Eric
authors.initials: JE
authors.lastname: Blatteau
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D003665:Decompression Sickness / Q000175:diagnosis*; D004242:Diving / Q000502:physiology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D