title: Rates of coronary intervention due to de novo significant atherosclerosis and cardiac death are very low in Korean patients with vasospastic angina: 36-month follow-up results of the Vasospastic Angina in the Catholic Medical Center (VA-CMC) registry.
abstract: BACKGROUND
  The rate of percutaneous coronary intervention (PCI) due to the development of significant atherosclerosis and the cardiac mortality rate in Korean patients with vasospastic angina (VSA) was estimated.
  
  
  RESULTS
  A total of 831 patients with VSA from 8 centers were registered in the Vasospastic Angina in the Catholic Medical Center (VA-CMC) registry. Their provocation tests for VSA showed positive results. The patients with significant atherosclerosis (>50% luminal narrowing) on the baseline angiography were excluded. Subjects were VSA patients without significant atherosclerosis. A total of 745 patients were included in the final analysis. The mean follow-up duration was 36.1±9.8 months. The PCI rate was 2.01% (15/745). Current smoking (odds ratio: 2.31, P<0.05) and high levels of baseline high-sensitivity C-reactive protein (hsCRP) (odds ratio: 1.57, P<0.05) were independent risk factors for PCI. The mortality rate was 2.55% (19/745). Eleven patients died of cardiac causes (1.48%). Cessation of medication was an independent risk factor for cardiac mortality (odds ratio: 1.47, P<0.05). The mean duration from the diagnosis to the cardiac deaths was 10.6±4.3 months.
  
  
  CONCLUSIONS
  Korean patients with VSA demonstrated low rates of development of significant atherosclerosis leading to PCI and cardiac mortality. However, cessation of medication, smoking, and high baseline hsCRP were the independent risk factors for unfavorable outcomes.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, South Korea.
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Shin
authors.forename: Sang Hong
authors.initials: SH
authors.lastname: Baek
authors.forename: Suk Min
authors.initials: SM
authors.lastname: Seo
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Dong Bin
authors.initials: DB
authors.lastname: Kim
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Her
authors.forename: Pum-Joon
authors.initials: PJ
authors.lastname: Kim
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Hee Yeol
authors.initials: HY
authors.lastname: Kim
authors.forename: Ki Dong
authors.initials: KD
authors.lastname: Yoo
authors.forename: Ki-Bae
authors.initials: KB
authors.lastname: Seung
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D003643:Death; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D012042:Registries; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors