title: [Effect of Lycium ruthenicum anthocyanins on atherosclerosis in mice].
abstract: OBJECTIVE
  To study the effect of Lycium ruthenicum anthocyanins on atherosclerosis (AS) in mice.
  
  
  METHODS
  Normal mice were taken as the control group, and hyperlipemia mice were divided into the model group, Lycium ruthenicum anthocyanins low, medium and high dose groups, and the simvastatin drug control group. After the oral administration, blood lipid indicators were detected by enzymatic analysis. The histomorphological changes in aortas, hearts and livers were observed, and liver-related indicators were determined by using hematoxylin-eosin (HE) staining.
  
  
  RESULTS
  Compared with the high-fat group, L. ruthenicum anthocyanins low, medium and high dose groups showed significant decrease in total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and atherosclerotic index (AI) (P < 0.05). However, high-density lipoprotein cholesterol (HDL-C) level showed a trend of higher than the model group. Liver's total antioxidant capacity (T-AOC), Glutathione peroxidase (GSH-PX), lipoprotein lipase (LPL) were significantly increased (P < 0.05), malondialdehyde (MDA) was markedly decreased (P < 0.01); the percentage of aortic plaque area of each anthocyanins dose group in the total area was significantly lower than the model group (P < 0.05); severity of aorta, heart and liver were significantly lighter than the high-fat group. But the media dose group was similar with the simvastatin group.
  
  
  CONCLUSIONS
  L. ruthenicum anthocyanins can interfere the formation of AS, while lowering blood lipid levels in mice.
authors.affiliation: Life Sciences Institute, Xinjiang Normal University, Urumqi 830054, China. linli0426@126.com
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Haiying
authors.initials: H
authors.lastname: Lv
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ma
authors.forename: Yiping
authors.initials: Y
authors.lastname: Qian
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000517:prevention & control*; D001835:Body Weight / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000473:pathology; D032305:Lycium / Q000737:chemistry*; D008297:Male; D051379:Mice; D008517:Phytotherapy
chemical_list: D000872:Anthocyanins; D008055:Lipids; D005979:Glutathione Peroxidase