title: Lipoprotein-associated phospholipase A2 and serum lipid levels in subjects with chronic periodontitis and hyperlipidemia.
abstract: OBJECTIVE
  To evaluate the relationships between clinical periodontal parameters and levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipid profile markers in subjects with or without hyperlipidaemia.
  
  
  METHODS
  Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. The clinical periodontal parameters, the serum concentrations of Lp-PLA2, lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and white blood cell (WBC) counts were determined and compared between different groups. Linear regression analysis was performed to identify the contributing factors of Lp-PLA2.
  
  
  RESULTS
  Serum Lp-PLA2 level in the CP/HPL group and the CP group was significantly higher than in the healthy group. TC and TG levels in the CP/HPL group were higher than in the CP and control groups. No difference was observed for levels HDL-c and LDL-c and WBC counts among the groups. Linear regression analysis showed that the serum level of Lp-PLA2 was positively associated with bleeding on probing and WBC counts.
  
  
  CONCLUSIONS
  Elevated level of Lp-PLA2 is associated with periodontal inflammation, indicating that periodontal treatment could reduce the risk of cardiovascular disease in CP subjects with hyperlipidaemia.
authors.affiliation: Department of Periodontlogy, Peking University School, Beijing, People's Republic of China.
authors.forename: Shuang Ying
authors.initials: SY
authors.lastname: Zhou
authors.forename: Wen Mei
authors.initials: WM
authors.lastname: Xiao
authors.forename: Xiang Ying
authors.initials: XY
authors.lastname: Ouyang
mesh_terms: D016022:Case-Control Studies; D002908:Chronic Disease; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000201:enzymology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000378:metabolism*; D010518:Periodontitis / Q000097:blood* / Q000201:enzymology; D054467:Phospholipases A2 / Q000378:metabolism*
chemical_list: D008055:Lipids; D008074:Lipoproteins; D054467:Phospholipases A2