title: Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders.
abstract: The ongoing development of animal models of neurological and psychiatric disorders in combination with the development of advanced nuclear magnetic resonance (NMR) techniques and instrumentation has led to increased use of in vivo proton NMR spectroscopy ((1)H-MRS) for neurochemical analyses. (1)H-MRS is one of only a few analytical methods that can assay in vivo and longitudinal neurochemical changes associated with neurological and psychiatric diseases, with the added advantage of being a technique that can be utilized in both preclinical and clinical studies. In this review, recent progress in the use of (1)H-MRS to investigate animal models of neurological and psychiatric disorders is summarized with examples from the literature and our own work.
authors.affiliation: Department of Biochemistry, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Moonnoh R
authors.initials: MR
authors.lastname: Lee
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Denic
authors.forename: David J
authors.initials: DJ
authors.lastname: Hinton
authors.forename: Prasanna K
authors.initials: PK
authors.lastname: Mishra
authors.forename: Doo-Sup
authors.initials: DS
authors.lastname: Choi
authors.forename: Istvan
authors.initials: I
authors.lastname: Pirko
authors.forename: Moses
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Slobodan I
authors.initials: SI
authors.lastname: Macura
mesh_terms: D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D001523:Mental Disorders / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D019964:Mood Disorders / Q000378:metabolism; D009103:Multiple Sclerosis / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D051381:Rats
chemical_list: D015415:Biomarkers