title: [Association study of NOS1 gene polymorphisms and schizophrenia].
abstract: OBJECTIVE
  To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.
  
  
  METHODS
  Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.
  
  
  RESULTS
  One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.
  
  
  CONCLUSIONS
  Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.
authors.affiliation: Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Ma
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Jun-yao
authors.initials: JY
authors.lastname: Wu
authors.forename: Ying-cheng
authors.initials: YC
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Ming-li
authors.initials: ML
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Zong-ling
authors.initials: ZL
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D052248:Nitric Oxide Synthase Type I / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D055815:Young Adult
chemical_list: C496320:NOS1 protein, human; D052248:Nitric Oxide Synthase Type I