title: Treatment of psoriasis and long-term maintenance using 308 nm excimer laser, clobetasol spray, and calcitriol ointment: a case series.
abstract: Psoriasis is a chronic inflammatory skin disease that is characterized by thickened red plaques covered with silvery scales. Excimer laser therapy is a cutting-edge advancement in UVB phototherapy. In contrast to traditional phototherapy, the 308 nm excimer laser only targets psoriasis plaques, while it spares uninvolved skin. It allows for treatment with a supra-erythmogenic dose of UVB irradiation. Targeted UVB therapy is a possible treatment especially for many who have failed topical treatments, systemic therapy, and traditional phototherapy. For safe and effective psoriasis treatment, a combination of therapies may be used, including a combination of laser treatment with topical medications. We present two cases demonstrating effective treatment with excimer laser in conjunction with clobetasol spray and calcitriol ointment for 12 weeks. Long-term near-clearance of psoriasis was sustained after 6 months and one-year follow up periods without further therapy.
authors.affiliation: University of Utah School of Medicine, Salt Lake City, UT, USA. jillianwwong@gmail.com
authors.forename: Jillian W
authors.initials: JW
authors.lastname: Wong
authors.forename: Tien V
authors.initials: TV
authors.lastname: Nguyen
authors.forename: Tina
authors.initials: T
authors.lastname: Bhutani
authors.forename: John Y M
authors.initials: JY
authors.lastname: Koo
mesh_terms: D000328:Adult; D002117:Calcitriol / Q000008:administration & dosage / Q000627:therapeutic use*; D002990:Clobetasol / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D053685:Laser Therapy; D060046:Maintenance Chemotherapy; D008297:Male; D011565:Psoriasis / Q000628:therapy*; D012720:Severity of Illness Index; D014467:Ultraviolet Therapy; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D014815:Vitamins; D002990:Clobetasol; D002117:Calcitriol