title: Exploring the endocrine manifestations of DICER1 mutations.
abstract: The discovery of each new cancer susceptibility gene answers one set of questions but poses many more. In this article, we outline a recent example: a new cancer syndrome caused by germline mutations in DICER1, responsible for microRNA processing. In particular, we discuss the endocrine manifestations of mutations in this crucial gene.
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital for Children, Subiaco, Western Australia 6008, Australia.
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Choong
authors.forename: John R
authors.initials: JR
authors.lastname: Priest
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D018095:Germ-Line Mutation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism; D023421:Models, Animal; D010641:Phenotype; D043244:Ribonuclease III / Q000235:genetics*
chemical_list: D035683:MicroRNAs; C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases