title: Closed-loop control of epilepsy by transcranial electrical stimulation.
abstract: Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.
authors.forename: Antal
authors.initials: A
authors.lastname: Berényi
authors.forename: Mariano
authors.initials: M
authors.lastname: Belluscio
authors.forename: Dun
authors.initials: D
authors.lastname: Mao
authors.forename: György
authors.initials: G
authors.lastname: Buzsáki
mesh_terms: D000818:Animals; D058256:Brain Waves; D002540:Cerebral Cortex / Q000503:physiopathology; D046690:Deep Brain Stimulation; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004832:Epilepsy, Absence / Q000503:physiopathology / Q000628:therapy*; D025461:Feedback, Physiological; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D013788:Thalamus / Q000503:physiopathology