title: Breast milk metal ion levels in a young and active patient with a metal-on-metal hip prosthesis.
abstract: Metal-on-metal resurfacing arthroplasty of the hip has been used increasingly over the last 10 years in younger active patients. The dissolution of the metal wear particles results in measurable increases in cobalt and chromium ions in the serum and urine of patients with a metal-on-metal bearing. We measured the cobalt, chromium, and molybdenum ion levels in urine; serum; and breast milk in a young and active patient with a metal-on-metal hip prosthesis after a pathologic fracture of the femoral neck. Metal-on-metal hip prosthesis leads to increasing levels of molybdenum in breast milk in the short-term follow-up. There are no increasing levels of chromium and cobalt ions in breast milk. Besides the already known elevated concentrations in serum of chromium and cobalt after implantation of a metal-on-metal hip prosthesis, we found no increasing levels of chromium and cobalt in urine.
authors.affiliation: Department of Orthopaedic Surgery, St. Elisabeth Hospital, Tilburg, the Netherlands.
authors.forename: Raymond
authors.initials: R
authors.lastname: Nelis
authors.forename: Jan
authors.initials: J
authors.lastname: de Waal Malefijt
authors.forename: Taco
authors.initials: T
authors.lastname: Gosens
mesh_terms: D000328:Adult; D002804:Chondroblastoma / Q000175:diagnosis / Q000601:surgery; D002857:Chromium / Q000032:analysis* / Q000097:blood / Q000652:urine; D003035:Cobalt / Q000032:analysis* / Q000097:blood / Q000652:urine; D005260:Female; D005265:Femoral Neck Fractures / Q000601:surgery; D005266:Femoral Neoplasms / Q000175:diagnosis / Q000601:surgery; D062785:Hemiarthroplasty; D006621:Hip Joint; D006622:Hip Prosthesis; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D008982:Molybdenum / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D002857:Chromium; D003035:Cobalt; D008982:Molybdenum