title: Miniaturization of mechanical circulatory support systems.
abstract: Heart failure (HF) is increasing worldwide and represents a major burden in terms of health care resources and costs. Despite advances in medical care, prognosis with HF remains poor, especially in advanced stages. The large patient population with advanced HF and the limited number of donor organs stimulated the development of mechanical circulatory support (MCS) devices as a bridge to transplant and for destination therapy. However, MCS devices require a major operative intervention, cardiopulmonary bypass, and blood component exposure, which have been associated with significant adverse event rates, and long recovery periods. Miniaturization of MCS devices and the development of an efficient and reliable transcutaneous energy transfer system may provide the vehicle to overcome these limitations and usher in a new clinical paradigm in heart failure therapy by enabling less invasive beating heart surgical procedures for implantation, reduce cost, and improve patient outcomes and quality of life. Further, it is anticipated that future ventricular assist device technology will allow for a much wider application of the therapy in the treatment of heart failure including its use for myocardial recovery and as a platform for support for cell therapy in addition to permanent long-term support.
authors.affiliation: Departments of Bioengineering & Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA.
authors.forename: Guruprasad A
authors.initials: GA
authors.lastname: Giridharan
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lee
authors.forename: Mickey
authors.initials: M
authors.lastname: Ising
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sobieski
authors.forename: Steven C
authors.initials: SC
authors.lastname: Koenig
authors.forename: Laman A
authors.initials: LA
authors.lastname: Gray
authors.forename: Mark S
authors.initials: MS
authors.lastname: Slaughter
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D057785:Catheters; D004867:Equipment Design; D006333:Heart Failure / Q000601:surgery / Q000628:therapy; D006801:Humans; D008904:Miniaturization