title: Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells.
abstract: Preparation and characterization of CS/Fe(3)O(4)/CMC composite scaffolds including the morphology, crystallinity, and the in vitro efficacy as antibiotic delivery vehicles as well as their influence on the eukaryotic cells are reported. The results demonstrated that the magnetic polymeric composite scaffolds are exhibiting structural and functional properties that recommend them for further applications in the biomedical field. They improve the activity of currently used antibiotics belonging to penicillins, macrolides, aminoglycosides, rifampicines and quinolones classes, representing potential macromolecular carriers for these antimicrobial substances, to achieve extracellular and intracellular targets. The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner.
authors.affiliation: University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1-7, 011061 Bucharest, Romania. grumezescu@yahoo.com
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Grumezescu
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Andronescu
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Dan Eduard
authors.initials: DE
authors.lastname: Mihaiescu
authors.forename: Mariana Carmen
authors.initials: MC
authors.lastname: Chifiriuc
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000737:chemistry*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D005057:Eukaryotic Cells; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D060328:Magnetic Phenomena; D011387:Prokaryotic Cells; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D048271:Chitosan; D002266:Carboxymethylcellulose Sodium; D052203:Ferrosoferric Oxide