title: A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years.
abstract: OBJECTIVE
  To evaluate the hypothesis that a mechanical stimulus (30-min walk) will produce a change in serum concentrations of cartilage oligomeric matrix protein (COMP) that is associated with cartilage thickness changes on magnetic resonance imaging (MRI).
  
  
  METHODS
  Serum COMP concentrations were measured by enzyme-linked immunosorbent assay in 17 patients (11 females, age: 59.0±9.2 years) with medial compartment knee osteoarthritis (OA) at study entry immediately before, immediately after, 3.5 h, and 5.5 h after a 30-min walking activity. Cartilage thickness changes in the medial femur and medial tibia were determined from MR images taken at study entry and at 5-year follow-up. Relationships between changes in cartilage thickness and COMP levels, with post-activity concentrations expressed as a percentage of pre-activity levels, were assessed by the calculation of Pearson correlation coefficients and by multiple linear regression analysis, with adjustments for age, sex, and body mass index (BMI).
  
  
  RESULTS
  Changes in COMP levels 3.5 h and 5.5 h post-activity were correlated with changes in cartilage thickness in the medial femur and tibia at the 5-year follow-up. The results were strengthened after analyses were adjusted for age, sex, and BMI. Neither baseline pre-activity COMP levels nor changes in COMP levels immediately post-activity were correlated with cartilage thickness changes.
  
  
  CONCLUSIONS
  The results of this study support the hypothesis that a change in COMP concentration induced by a mechanical stimulus is associated with cartilage thinning at 5 years. Mechanically-induced changes in mechano-sensitive biomarkers should be further explored in the context of stimulus-response models to improve the ability to assess OA progression.
authors.affiliation: Center for Tissue Regeneration, Repair, and Restoration, Palo Alto VA, Palo Alto, CA, United States. jerhart@stanford.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Erhart-Hledik
authors.forename: J
authors.initials: J
authors.lastname: Favre
authors.forename: J L
authors.initials: JL
authors.lastname: Asay
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
authors.forename: N J
authors.initials: NJ
authors.lastname: Giori
authors.forename: A
authors.initials: A
authors.lastname: Mündermann
authors.forename: T P
authors.initials: TP
authors.lastname: Andriacchi
mesh_terms: D001696:Biomechanical Phenomena; D015992:Body Mass Index; D064236:Cartilage Oligomeric Matrix Protein; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D015444:Exercise / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D005269:Femur / Q000473:pathology; D006023:Glycoproteins / Q000097:blood*; D049670:History, 17th Century; D006801:Humans; D008297:Male; D064235:Matrilin Proteins; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000473:pathology*; D013314:Stress, Mechanical; D013977:Tibia / Q000473:pathology; D016138:Walking / Q000502:physiology*
chemical_list: D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human