title: Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach.
abstract: A new ratiometric fluorescent sensor for Cu(2+), WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu(2+) over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu(2+) has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.
authors.affiliation: School of Chemistry and Chemical Engineering and School of Material Science and Engineering, Liaocheng University, Liaocheng, PR China. chliuzp@163.com
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Liu
authors.forename: Changli
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Wang
authors.forename: Weijiang
authors.initials: W
authors.lastname: He
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry; D003300:Copper / Q000032:analysis*; D005260:Female; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000634:Aminoquinolines; D005456:Fluorescent Dyes; D053644:Naphthalimides; D003300:Copper; C080436:8-aminoquinoline