title: [Study on optimization method of dynamic extraction process].
abstract: OBJECTIVE
  To establish a new optimized extraction process based on dynamic changes in extract concentration during the extraction process.
  
  
  METHODS
  Sanqi was taken as an example to compare the concentration of marker components, total solids yield and similarity evaluation of the fingerprint images of extracts by orthogonal design optimization process and dynamic optimization process to assess the feasibility of dynamic process optimization method.
  
  
  RESULTS
  The concentration of marker components and total solids yield vary less than 5%, with a 100% of similarity in fingerprints, indicating basic coincidence between extracts by the two optimized processes. The dynamic process optimization process could save 79% of the extraction time.
  
  
  CONCLUSIONS
  In the extraction time, the dynamic optimization process is superior to the orthogonal design optimization process in that it can significantly reduce the extraction time and lower production costs.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. wdz1985@163.com
authors.forename: Dongzhe
authors.initials: D
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhang
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Wang
authors.forename: An
authors.initials: A
authors.lastname: Liu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification*; D053723:Panax notoginseng / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal