title: In-vivo human brain molecular imaging with a brain-dedicated PET/MRI system.
abstract: Advances in the new-generation of ultra-high-resolution, brain-dedicated positron emission tomography-magnetic resonance imaging (PET/MRI) systems have begun to provide many interesting insights into the molecular dynamics of the brain. First, the finely delineated structural information from ultra-high-field MRI can help us to identify accurate landmark structures, thereby making it easier to locate PET activation sites that are anatomically well-correlated with metabolic or ligand-specific organs in the neural structures in the brain. This synergistic potential of PET/MRI imaging is discussed in terms of neuroscience and neurological research from both translational and basic research perspectives. Experimental results from the hippocampus, thalamus, and brainstem obtained with (18)F-fluorodeoxyglucose and (11)C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile are used to demonstrate the potential of this new brain PET/MRI system.
authors.affiliation: Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea. zcho@gachon.ac.kr
authors.forename: Zang Hee
authors.initials: ZH
authors.lastname: Cho
authors.forename: Young Don
authors.initials: YD
authors.lastname: Son
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Choi
authors.forename: Hang Keun
authors.initials: HK
authors.lastname: Kim
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: Seiji
authors.initials: S
authors.lastname: Ogawa
authors.forename: Young Bo
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000814:Aniline Compounds; D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D004867:Equipment Design; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals; D013440:Sulfides
chemical_list: C412822:3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013440:Sulfides; D019788:Fluorodeoxyglucose F18