title: In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid.
abstract: The conventional chemotherapy agent, doxorubicin, is of limited clinical use because of its systemic toxicity toward normal healthy tissue. A new doxorubicin conjugate with α-linolenic acid showed good anti-tumor activity with lower toxicity than free doxorubicin and exhibited an active tumor-targeting profile due to the introduction of α-linolenic acid which might be an effective tumor-targeting moiety for the modification of chemotherapeutics.
authors.affiliation: Department of Pharmaceutics, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Menglei
authors.initials: M
authors.lastname: Huan
authors.forename: Han
authors.initials: H
authors.lastname: Cui
authors.forename: Zenghui
authors.initials: Z
authors.lastname: Teng
authors.forename: Bangle
authors.initials: B
authors.lastname: Zhang
authors.forename: Jieping
authors.initials: J
authors.lastname: Wang
authors.forename: Xinyou
authors.initials: X
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Xia
authors.forename: Siyuan
authors.initials: S
authors.lastname: Zhou
authors.forename: Qibing
authors.initials: Q
authors.lastname: Mei
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D004705:Endocytosis / Q000187:drug effects; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D016513:Mice, SCID; D058990:Molecular Targeted Therapy; D009368:Neoplasm Transplantation; D015996:Survival Rate; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays; D017962:alpha-Linolenic Acid / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D017962:alpha-Linolenic Acid; D004317:Doxorubicin