title: Dorsal genital nerve stimulation in patients with detrusor overactivity: a systematic review.
abstract: This study evaluates the outcome of trials to stimulate the dorsal genital nerve (DGN) in patients with lower urinary tract dysfunction. The aim of most studies was to suppress detrusor overactivity in patients with overactive bladder (OAB) syndrome by DGN stimulation. A literature search was performed using Pub Med, Web of Science, and Scopus databases (1980 to April 2012) for clinical trials of DGN stimulation in patients with detrusor overactivity. Seventeen studies were found in the literature. In the studies, different patterns of DGN stimulation were applied. The patterns were either continuous, conditional, or semi-conditional; on an acute or on a chronic basis. DGN stimulation lead to improvement of bladder capacity and reduction in urgency and/or incontinence episodes in many patients. The outcomes of conditional stimulation were comparable to continuous stimulation with respect to improvement of bladder capacity. The publications give evidence that DGN stimulation increases bladder capacity and suppresses involuntary detrusor contractions. Implantable DGN stimulation electrodes can open the way for more prolonged studies in larger patient groups to assess the effectiveness of chronic DGN stimulation in patients with OAB syndrome. Chronic DGN stimulation seems to be of value in the management of OAB syndrome.
authors.affiliation: Department of Urology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, route 659, 6500 HB, Nijmegen, the Netherlands. f.farag@uro.umcn.nl
authors.forename: Fawzy F
authors.initials: FF
authors.lastname: Farag
authors.forename: Frank M J
authors.initials: FM
authors.lastname: Martens
authors.forename: Nico J M
authors.initials: NJ
authors.lastname: Rijkhoff
authors.forename: John P F A
authors.initials: JP
authors.lastname: Heesakkers
mesh_terms: D000328:Adult; D002987:Clitoris / Q000294:innervation; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D010413:Penis / Q000294:innervation; D053201:Urinary Bladder, Overactive / Q000503:physiopathology* / Q000628:therapy*