title: A stochastic SIR model with contact-tracing: large population limits and statistical inference.
abstract: This paper is devoted to the presentation and study of a specific stochastic epidemic model accounting for the effect of contact-tracing on the spread of an infectious disease. Precisely, one considers here the situation in which individuals identified as infected by the public health detection system may contribute to detecting other infectious individuals by providing information related to persons with whom they have had possibly infectious contacts. The control strategy, which consists of examining each individual who has been able to be identified on the basis of the information collected within a certain time period, is expected to efficiently reinforce the standard random-screening-based detection and considerably ease the epidemic. In the novel modelling of the spread of a communicable infectious disease considered here, the population of interest evolves through demographic, infection and detection processes, in a way that its temporal evolution is described by a stochastic Markov process, of which the component accounting for the contact-tracing feature is assumed to be valued in a space of point measures. For adequate scalings of the demographic, infection and detection rates, it is shown to converge to the weak deterministic solution of a PDE system, as a parameter n, interpreted as the population size, roughly speaking, becomes larger. From the perspective of the analysis of infectious disease data, this approximation result may serve as a key tool for exploring the asymptotic properties of standard inference methods such as maximum likelihood estimation. We state preliminary statistical results in this context. Eventually, relations of the model with the available data of the HIV epidemic in Cuba, in which country a contact-tracing detection system has been set up since 1986, is investigated and numerical applications are carried out.
authors.affiliation: Laboratoire TCI UMR CNRS/Institut Telecom No. 5141, Paris Cedex 13, France. stephan.clemencon@telecom-paristech.fr
authors.forename: Stéphan
authors.initials: S
authors.lastname: Clémençon
authors.forename: Viet Chi
authors.initials: VC
authors.lastname: Tran
authors.forename: Hector
authors.initials: H
authors.lastname: de Arazoza
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology*; D003198:Computer Simulation; D016358:Contact Tracing / Q000706:statistics & numerical data*; D003462:Cuba / Q000453:epidemiology; D004198:Disease Susceptibility; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D016013:Likelihood Functions; D008954:Models, Biological; D015233:Models, Statistical; D011157:Population Dynamics; D013269:Stochastic Processes