title: Evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of Plateau and Nasarawa States, Nigeria.
abstract: An average of six annual rounds of ivermectin and albendazole were distributed in Plateau and Nasarawa States, Nigeria, to eliminate lymphatic filariasis. From 2007 to 2008, population-based surveys were implemented in all 30 local government areas (LGAs) of the two states to determine the prevalence of Wuchereria bancrofti antigenemia to assess which LGA mass drug administration (MDA) could be halted. In total, 36,681 persons from 7,819 households were examined for filarial antigen as determined by immunochromatographic card tests. Overall antigen prevalence was 3.05% (exact upper 95% confidence interval [CI] = 3.41%) with an upper 95% CI range by LGA of 0.50-19.3%. Among 3,233 children 6-7 years of age, overall antigen prevalence was 1.71% (exact upper 95% CI = 2.19%), too high to recommend generally halting MDA in the two-state area. However, based on criteria of < 2% antigenemia among persons > 2 years of age, stopping MDA was recommended for 10 LGAs.
authors.affiliation: The Carter Center, Atlanta, Georgia; The Carter Center, Jos, Plateau State, Nigeria. jonathan.king@emory.edu
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: King
authors.forename: Abel
authors.initials: A
authors.lastname: Eigege
authors.forename: John
authors.initials: J
authors.lastname: Umaru
authors.forename: Nimzing
authors.initials: N
authors.lastname: Jip
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Miri
authors.forename: Jonathan
authors.initials: J
authors.lastname: Jiya
authors.forename: Kal M
authors.initials: KM
authors.lastname: Alphonsus
authors.forename: Yohanna
authors.initials: Y
authors.lastname: Sambo
authors.forename: Patricia
authors.initials: P
authors.lastname: Graves
authors.forename: Frank
authors.initials: F
authors.lastname: Richards
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000008:administration & dosage*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D000947:Antigens, Helminth / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D004605:Elephantiasis, Filarial / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012424:Rural Population; D014958:Wuchereria bancrofti / Q000254:growth & development*; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D007559:Ivermectin; D015766:Albendazole