title: Existence of Gαi2-expressing axon terminals in the goat main olfactory bulb.
abstract: In rodents, Gα(i2)-expressing sensory neurons (SNs) that co-express vomeronasal receptor type 1 (V1R) are specifically found in the vomeronasal organ (VNO) and project their axons to the accessory olfactory bulb (AOB). In goats, however, Gα(i2)/V1R-expressing SNs exist in both the VNO and the olfactory epithelium. Thus, we examined whether the Gα(i2)-expressing axons functionally project to the main olfactory bulb (MOB). We analyzed the expression of Gα(i2) in the olfactory bulb and found small Gα(i2)-immunoreactive clusters in the MOB. The Gα(i2)-immunoreactive axons in these clusters made synaptic contacts with second-order neurons in the MOB. These results suggest that some Gα(i2)-expressing SNs functionally project their axons to the MOB in goats.
authors.affiliation: Department of Dementia and Higher Brain Function, Integrated Neuroscience Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ohara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okamura
authors.forename: Masumi
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hagino-Yamagishi
mesh_terms: D000344:Afferent Pathways; D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D051960:GTP-Binding Protein alpha Subunit, Gi2 / Q000378:metabolism*; D006041:Goats / Q000378:metabolism*; D008854:Microscopy, Electron / Q000662:veterinary; D008856:Microscopy, Fluorescence / Q000662:veterinary; D009830:Olfactory Bulb / Q000166:cytology / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D011984:Sensory Receptor Cells / Q000378:metabolism*; D019147:Vomeronasal Organ / Q000166:cytology*
chemical_list: D051960:GTP-Binding Protein alpha Subunit, Gi2