title: Thinking outside the synapse: glycine at extrasynaptic NMDA receptors.
abstract: In this issue, Papouin et al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine. By enzymatically degrading endogenous glycine, they begin to address the enigmatic physiological and pathological roles for extrasynaptic NMDARs.
authors.affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA. john.gray@ucsf.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Gray
authors.forename: Roger A
authors.initials: RA
authors.lastname: Nicoll