title: The association of the metabolic profile in diabetes mellitus type 2 patients with obsessive-compulsive symptomatology and depressive symptomatology: new insights.
abstract: OBJECTIVE
  The aim of the present study was to explore the relationship between diabetes mellitus type 2, Obsessive- compulsive disorder (OCD) symptomatology and depressive symptomatology with the metabolic profile of diabetic patients.
  
  
  METHODS
  One hundred and thirty-one diabetic patients were randomly selected. In the first assessment all participants completed the Zung Self Rating Scale (ZUNG) and the Maudsley O-C Inventory Questionnaire (MOCI). After 1 year, diabetic patients that were initially uncontrolled (n = 31) (HbA1c > 7) were re-evaluated by the same psychometric tools. From those 31 patients, 10 had managed to control their metabolic profile.
  
  
  RESULTS
  In the first evaluation MOCI and the sub-scale of slowness were statistically related with the diabetic profile (controlled, HbA1c ≤ 7; uncontrolled, HbA1c > 7), with uncontrolled patients scoring significantly higher on the overall MOCI score and the factor of slowness of MOCI scale (P = 0.028). The analysis revealed a positive association between depressive symptomatology (P = 0.004) and obsessive-compulsive disorder symptomatology (P < 0.001) and the metabolic profile of the patients. In the second evaluation the patients that managed to control their metabolic profile scored lower in both ZDRS and MOCI, although these differences in scores failed to reach significance levels were indicative of a tendency.
  
  
  CONCLUSIONS
  The present results provide initial evidence that diabetes mellitus type 2 is associated with obsessive-compulsive disorder symptomatology and depressive symptomatology.
authors.affiliation: 1st Department of Psychiatry, Athens University Medical School, Eginition Hospital, Athens, Greece. kontange@hol.gr
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kontoangelos
authors.forename: Athanasios E
authors.initials: AE
authors.lastname: Raptis
authors.forename: Charalabos C
authors.initials: CC
authors.lastname: Papageorgiou
authors.forename: George N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: Andreas D
authors.initials: AD
authors.lastname: Rabavilas
authors.forename: George
authors.initials: G
authors.lastname: Dimitriadis
authors.forename: Sotirios A
authors.initials: SA
authors.lastname: Raptis
mesh_terms: D003866:Depressive Disorder / Q000150:complications / Q000523:psychology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome / Q000502:physiology*; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors