title: Favorable response of heavily treated Wilms' tumor to paclitaxel and carboplatin.
abstract: BACKGROUND
  Heavily treated Wilms' tumor responding to the combination of paclitaxel and carboplatin has not yet been reported.
  
  
  METHODS
  A 17-year-old man presented with hematuria. He received a diagnosis of Wilms' tumor with multiple lung metastases and was treated with preoperative chemotherapy including vincristine, dactinomycin, and doxorubicin, a right nephrectomy, and adjuvant chemotherapy, followed by pulmonary metastasectomy. During the next 8 years, he suffered from 4 relapses and has been treated with multiple anticancer agents including high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Finally, the disease progressed due to peritoneal and pleural metastases. With opioid administration for left shoulder pain due to pleural metastasis, he received combination chemotherapy with carboplatin (area under the curve = 4) and paclitaxel (175 mg/m(2)) on day 1. After 2 cycles, he achieved a partial response with mild toxicity. He received 7 cycles of the chemotherapy and the time to progression was 200 days.
  
  
  CONCLUSIONS
  In a refractory case after intensive treatments, we succeeded to control the disease for a while.
authors.affiliation: Department of Hematology, Oncology and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Ozaki
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.forename: Eiki
authors.initials: E
authors.lastname: Ichihara
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Hotta
authors.forename: Isao
authors.initials: I
authors.lastname: Oze
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kurimoto
authors.forename: Soichiro
authors.initials: S
authors.lastname: Fushimi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ogino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tabata
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kiura
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel