title: Cytomegalovirus-induced cutaneous microangiopathy manifesting as lower limb ischemia in a human immunodeficiency virus-infected patient.
abstract: Cutaneous infections by cytomegalovirus (CMV) are rare and often difficult to diagnose both clinically and histopathologically. A wide range of different clinical manifestations have been described in the literature, especially in immunosuppressed patients. CMV-induced thrombosis has also been reported in these patients, and various mechanisms have been proposed to explain the role of CMV in the thrombotic process, including direct damage of the endothelial cells, activation of coagulation factors and inducing the production of antiphospholipid antibodies. We present the case of a human immunodeficiency virus (HIV)-infected woman who developed distal ischemic lesions of the lower extremities during a generalized CMV infection. We discuss the role of CMV and antiphospholipid antibodies in the pathogenesis of thrombosis in immunosuppressed patients.
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain. anamaria.molinaruiz@gmail.com
authors.forename: Ana M
authors.initials: AM
authors.lastname: Molina-Ruiz
authors.forename: Rafael
authors.initials: R
authors.lastname: Luque
authors.forename: Terasa
authors.initials: T
authors.lastname: Zulueta
authors.forename: Jose
authors.initials: J
authors.lastname: Bernabeu
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007511:Ischemia / Q000473:pathology / Q000821:virology*; D007866:Leg / Q000098:blood supply; D012874:Skin Diseases, Infectious / Q000473:pathology / Q000821:virology; D014652:Vascular Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology