title: Systematic, evidence-based discovery of biomarkers at the NCI.
abstract: In the past decade, biomarker discovery has become ubiquitous in cancer research. However, despite this interest in biomarker research, few newly-characterized biomarkers have emerged as clinically-used entities. Here, we review the current state of biomarker research in cancer and identify challenges that stall many biomarker discovery efforts. We outline a model for systematic biomarker discovery, exemplified by recent efforts in prostate cancer, in which bioinformatics plays a central role in identifying promising new candidate biomarkers. Finally, we review the role of the National Cancer Institute's Early Detection Research Network (EDRN) in biomarker studies and the importance of EDRN-led efforts to establish a research standard for more effective biomarker discovery efforts.
authors.affiliation: Michigan Center for Translational Pathology, University of Michigan Medical School, 1400 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Prensner
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
authors.forename: Sudhir
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D014408:Biomarkers, Tumor; D035843:Biomedical Research; D019295:Computational Biology; D055088:Early Detection of Cancer; D006801:Humans; D008297:Male; D054547:National Cancer Institute (U.S.); D011471:Prostatic Neoplasms; D014481:United States
chemical_list: D014408:Biomarkers, Tumor