title: LSD and 9,10-dihydro-LSD analyses in street drug blotter samples via easy ambient sonic-spray ionization mass spectrometry (EASI-MS).
abstract: Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, seven for 9,10-dihydro-LSD, and another six samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs.
authors.affiliation: ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, State University of Campinas-UNICAMP, Campinas, SP, Brazil. wandersonromao@gmail.com
authors.forename: Wanderson
authors.initials: W
authors.lastname: Romão
authors.forename: Bruno D
authors.initials: BD
authors.lastname: Sabino
authors.forename: Maria Izabel M S
authors.initials: MI
authors.lastname: Bueno
authors.forename: Boniek G
authors.initials: BG
authors.lastname: Vaz
authors.forename: Amadeu C
authors.initials: AC
authors.lastname: Júnior
authors.forename: Adriano O
authors.initials: AO
authors.lastname: Maldaner
authors.forename: Eustáquio V R
authors.initials: EV
authors.lastname: de Castro
authors.forename: Rogério A
authors.initials: RA
authors.lastname: Lordeiro
authors.forename: Clésia C
authors.initials: CC
authors.lastname: Nascentes
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Rodinei
authors.initials: R
authors.lastname: Augusti