title: Design and properties of functional nanotubes from the self-assembly of cyclic peptide templates.
abstract: β-Sheet forming self assembling cyclic peptides offer a versatile scaffold for the construction and control of hydrogen-bonded nanotube assemblies. These structures have major advantages over other nanoscale tubular structures, including sub-nanometer control over the internal diameter, and the ability to control internal and external chemical functionality. This Tutorial Review presents an overview of nanotubes derived from this class of cyclic peptides. The design rationale for functional nanotubes based on cyclic peptide ring size and chemical functionality is discussed. Additionally, we highlight the recent expansion of the nanotube toolbox through conjugation of (macro)molecules to the cyclic peptides. These provide additional functionality and control nanotube dimensions that could potentially prove beneficial in future applications.
authors.affiliation: Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney, Building F11, Sydney 2006, NSW, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Chapman
authors.forename: Maarten
authors.initials: M
authors.lastname: Danial
authors.forename: Ming Liang
authors.initials: ML
authors.lastname: Koh
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Jolliffe
authors.forename: Sébastien
authors.initials: S
authors.lastname: Perrier
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry; D018014:Gene Transfer Techniques; D006801:Humans; D007473:Ion Channels / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D007473:Ion Channels; D010456:Peptides, Cyclic; D011108:Polymers