title: mRNA localization and translational control in Drosophila oogenesis.
abstract: Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing on Drosophila where the relevant knowledge is most advanced. Links between mRNA localization and translational control mechanisms also are examined.
authors.affiliation: Department of Biology, Bellini Life Sciences Building, McGill University, Montréal, Québec H3G 0B1, Canada. paul.lasko@mcgill.ca
authors.forename: Paul
authors.initials: P
authors.lastname: Lasko
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D008957:Models, Genetic; D009866:Oogenesis / Q000235:genetics*; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D012333:RNA, Messenger