title: High-performance liquid chromatographic determination of alpha-tocopherol in inclusion complexes with cyclodextrins.
abstract: A new high performance liquid chromatography (HPLC)-based method is proposed for the determination of vitamin E, free and in inclusion complexes with natural beta-cyclodextrin and its 2-hydroxy derivative. The method has been validated on the basis of the following parameters: specificity, selectivity, linearity, precision, range and recovery.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Karol Marcinkowski University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Gierlach-Hładoń
authors.forename: Kinga
authors.initials: K
authors.lastname: Lange
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry; D002138:Calibration; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D004337:Drug Carriers; D004339:Drug Compounding; D057927:Hydrophobic and Hydrophilic Interactions; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012995:Solubility; D024502:alpha-Tocopherol / Q000032:analysis* / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D024502:alpha-Tocopherol