title: N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study.
abstract: A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.
authors.affiliation: State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China. jianwu2691@yahoo.com.cn
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Shenghong
authors.initials: S
authors.lastname: Kang
authors.forename: Qinkun
authors.initials: Q
authors.lastname: Yuan
authors.forename: Lijun
authors.initials: L
authors.lastname: Luo
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.forename: Qingcai
authors.initials: Q
authors.lastname: Shi
authors.forename: Song
authors.initials: S
authors.lastname: Yang
mesh_terms: D000478:Alkylation; D000818:Animals; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009036:Moths / Q000187:drug effects*; D010571:Pest Control; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D011724:Pyridazines