title: Gilvocarcin HE: a new polyketide glycoside from Streptomyces sp.
abstract: A new antimicrobial polyketide glycoside (1) and three known compounds, gilvocarcins H (2), V (3) and M (4) were isolated from the ethyl acetate extract of Streptomyces sp. QD01-2. The structure of (1) was established by spectroscopic analysis, X-ray single crystal diffraction and CD spectra. The new compound (1) showed potent antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Candida albicans, with MIC values of 0.5-5.0 μM. Compound (1) also showed weak cytotoxicity against the MCF-7, K562 and P388 cell lines, with IC(50) values of 36, 39 and 45 μM, respectively. The results showed that the vinyl side chain helps to increase the cytotoxicity and antimicrobial activities of gilvocarcin-type glycosides. In addition, the NMR data of gilvocarcin H (2) were also reported for the first time.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education of China, Ocean University of China, Qingdao, PR China.
authors.forename: Jiabo
authors.initials: J
authors.lastname: Hou
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Haijun
authors.initials: H
authors.lastname: Qu
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.forename: Xiancun
authors.initials: X
authors.lastname: Teng
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003374:Coumarins; D006027:Glycosides; D061065:Polyketides