title: Streptozotocin-induced sporadic Alzheimer's disease: selection of appropriate dose.
abstract: The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Jogender
authors.initials: J
authors.lastname: Mehla
authors.forename: Monika
authors.initials: M
authors.lastname: Pahuja
authors.forename: Yogendra Kumar
authors.initials: YK
authors.lastname: Gupta
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced* / Q000473:pathology* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000008:administration & dosage* / Q000633:toxicity*
chemical_list: D013311:Streptozocin