title: Multidose pharmacokinetics of orally administered florfenicol in the channel catfish (Ictalurus punctatus).
abstract: Plasma disposition of florfenicol in channel catfish was investigated after an oral multidose (10 mg/kg for 10 days) administration in freshwater at water temperatures ranging from 24.7 to 25.9 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After the administration of florfenicol, the mean terminal half-life (t(1/2)), maximum concentration at steady-state (Css (max)), time of Css (max) (T(max)), minimal concentration at steady-state (Css (min)), and Vc /F were 9.0 h, 9.72 μg/mL, 8 h, 2.53 μg/mL, and 0.653 L/kg, respectively. These results suggest that florfenicol administered orally at 10 mg/kg body weight for 10 days could be expected to control catfish bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of <2.5 μg/mL.
authors.affiliation: Mississippi State University College of Veterinary Medicine, Stoneville, MS, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Gaunt
authors.forename: C
authors.initials: C
authors.lastname: Langston
authors.forename: C
authors.initials: C
authors.lastname: Wrzesinski
authors.forename: D
authors.initials: D
authors.lastname: Gao
authors.forename: P
authors.initials: P
authors.lastname: Adams
authors.forename: L
authors.initials: L
authors.lastname: Crouch
authors.forename: D
authors.initials: D
authors.lastname: Sweeney
authors.forename: R
authors.initials: R
authors.lastname: Endris
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary; D007059:Ictaluridae / Q000097:blood / Q000378:metabolism*; D053719:Tandem Mass Spectrometry / Q000379:methods / Q000662:veterinary; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol