title: Skin signs of severe systemic medication reactions.
abstract: Cutaneous medication reactions are often isolated to the skin and result in no serious systemic sequelae. There are a few rarer, but dangerous, medication reactions that can either be harbingers of life-threatening systemic reactions or lead to multisystem disease through their effects on the skin and mucous membranes. This article will further discuss these severe systemic medication reactions.
authors.affiliation: Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Treat
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever; D017408:Guidelines as Topic; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D010372:Pediatrics; D012867:Skin / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors