title: Cellular growth factors in relation to mortality from cardiovascular disease in middle-aged Japanese: the JACC study.
abstract: OBJECTIVE
  Limited evidence has been available on the relationships of cellular growth factors with cardiovascular disease in population-based samples.
  
  
  METHODS
  We conducted a nested case-control study under a large prospective cohort study (JACC study) where a total of 39,242 subjects aged 40-79 years provided serum sample. We measured cellular growth factors [insulin-like growth factors I, II and binding protein-3 (IGF-I, IGF-II and IGFBP-3) and transforming growth factor (TGF-β1)] among cases and controls, matched for sex, age, area of residence and year of serum storage.
  
  
  CONCLUSIONS
  During the follow-up for 9 years, there were 233 deaths from total stroke (49 subarachnoid hemorrhages, 55 intraparenchymal hemorrhages, 71 ischemic strokes), and 97 deaths from coronary heart disease. The multivariable odds ratio (95%CI) of intraparenchymal hemorrhage associated with a 1-SD increment of IGF-I (men:4 8 ng/ml, women: 61 ng/ml) was 0.31 (0.14-0.71). That of ischemic stroke associated with a 1-SD increment of TGF-β1 (men: 8.0 ng/ml, women: 10.9 ng/ml) was 0.58 (0.34-0.98). Serum IGF-II and IGFBP-3 were not associated with mortality from any outcomes. In conclusion, IGF-I was inversely associated with mortality from intraparenchymal hemorrhage while TGF-β1 was so with ischemic stroke, suggesting potential roles of cellular proliferation in the development or prognosis of stroke.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Japan. iso@pbhel.med.osaka-u.ac.jp
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Koutatsu
authors.initials: K
authors.lastname: Maruyama
authors.forename: Satoyo
authors.initials: S
authors.lastname: Ikehara
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002318:Cardiovascular Diseases / Q000401:mortality*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000401:mortality; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D053773:Transforming Growth Factor beta1; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II