title: Stereocontrolled total synthesis of (-)-englerin A.
abstract: The total synthesis of (-)-englerin A, a potent and selective inhibitor of renal cancer cell lines, is described. The key feature includes the stereocontrolled construction of the cyclopentane structure by taking advantage of a base-promoted epoxynitrile cyclization.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takahashi
authors.forename: Keita
authors.initials: K
authors.lastname: Komine
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yokoi
authors.forename: Jun
authors.initials: J
authors.lastname: Ishihara
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D008968:Molecular Conformation; D045789:Sesquiterpenes, Guaiane / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D045789:Sesquiterpenes, Guaiane; C534971:englerin A