title: Fifty percent patients avoid whole brain radiotherapy: stereotactic radiotherapy for multiple brain metastases: a retrospective analysis of a single center.
abstract: OBJECTIVE
  To summarize the outcomes of stereotactic radiotherapy (SRT), with or without whole-brain radiotherapy (WBRT), in the treatment of multiple brain metastasis and to explore the status of WBRT and SRT in the management of multiple brain metastasis.
  
  
  METHODS
  From May 1995 to April 2010, 98 patients with newly diagnosed, multiple brain metastasis were treated in our center. Forty-four patients were treated with SRT alone for the initial treatment, and 54 were treated with SRT + WBRT. Kaplan-Meier and Cox proportional hazards regression analyses were used for the survival analysis.
  
  
  RESULTS
  The median survival time (MST) was 13.5 months. No difference was observed in MST between the SRT and the SRT + WBRT groups (p = 0.578). The Karnofsky Performance Score at the time of treatment (p = 0.025), the interval time between diagnosis of primary tumor and brain metastasis (P = 0.012) and the situation of extracranial disease (p = 0.018) were significant predictors of survival. The crude distant intracranial recurrence (DIR) rates were 47.7 % in the SRT group and 24.1 % in the SRT + WBRT group (p = 0.018). In addition, 52.3 % patients in the SRT group were free from DIR and did not require WBRT in their whole lives.
  
  
  CONCLUSIONS
  Our data suggest that use of SRT as the initial treatment while reserving WBRT as the salvage therapy in case of distant intracranial recurrence made about 50 % of the patients avoid WBRT throughout the course of their lives and may be another optional treatment modality for multiple brain metastases.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Chen
authors.forename: Jianping
authors.initials: J
authors.lastname: Xiao
authors.forename: Xiangpan
authors.initials: X
authors.lastname: Li
authors.forename: Xuesong
authors.initials: X
authors.lastname: Jiang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Xu
authors.forename: Jianrong
authors.initials: J
authors.lastname: Dai
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012189:Retrospective Studies