title: Role of autophagy in acute myeloid leukemia therapy.
abstract: Despite its dual role in determining cell fate in a wide array of solid cancer cell lines, autophagy has been robustly shown to suppress or kill acute myeloid leukemia cells via degradation of the oncogenic fusion protein that drives leukemogenesis. However, autophagy also induces the demise of acute leukemia cells that do not express the known fusion protein, though the molecular mechanism remains elusive. Nevertheless, since it can induce cooperation with apoptosis and differentiation in response to autophagic signals, autophagy can be manipulated for a better therapy on acute myeloid leukemia.
authors.affiliation: Soochow University, Suzhou, Jiangsu, People's Republic of China.
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Zhang
authors.forename: Yu-Na
authors.initials: YN
authors.lastname: Niu
authors.forename: Na
authors.initials: N
authors.lastname: Yuan
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Chao
authors.forename: Qiu-Ping
authors.initials: QP
authors.lastname: Xu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.forename: Xue-Guang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Zhao
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001343:Autophagy / Q000187:drug effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D015514:Oncogene Proteins, Fusion / Q000378:metabolism*; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D015514:Oncogene Proteins, Fusion; D014212:Tretinoin