title: RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancer.
abstract: Cancer cell invasion and metastasis are the most important adverse prognostic factors for pancreatic cancer. Identification of biomarkers associated with outcome of pancreatic cancer may provide new approaches and targets for anticancer therapy. The aim of this study is to examine the relationship between the expression of RhoT1, Smad4 and p16 and metastasis and survival in patients with pancreatic cancer. The analysis showed that the high cytoplasmic expression levels of RhoT1, Smad4 and p16 in pancreatic cancer tissues had significantly negative correlation with lymph node metastasis (LNM) (P = 0.017, P = 0.032, P = 0.042, respectively). However, no significant association was observed between perineural invasion (PNI) and the expression of above three proteins (all P>0.05). Additionally, the survival analysis showed that the low expression levels of RhoT1 and Smad4 were significantly associated with worse survival (P = 0.034, P = 0.047, respectively). In conclusion, these results indicated that the low-expression levels of RhoT1 and Smad4 were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer.
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. huajiang666@yahoo.com.cn
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Chengzhi
authors.initials: C
authors.lastname: He
authors.forename: Shasha
authors.initials: S
authors.lastname: Geng
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Shizhang
authors.initials: S
authors.lastname: Zhu
authors.forename: Ximei
authors.initials: X
authors.lastname: Chen
authors.forename: Changqing
authors.initials: C
authors.lastname: Yang
authors.forename: HengJun
authors.initials: H
authors.lastname: Gao
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D051901:Smad4 Protein / Q000378:metabolism / Q000502:physiology*; D015996:Survival Rate; D020741:rho GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D024101:Mitochondrial Proteins; C497796:SMAD4 protein, human; D051901:Smad4 Protein; C473124:RHOT1 protein, human; D020741:rho GTP-Binding Proteins