title: Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.
abstract: The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 ((18)F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with (18)F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = -0.33; p = 0.003) and delayed recall scores (r = -0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline.
authors.affiliation: Center for Alzheimer Research and Treatment, Departments of Neurology, Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. reisa@rics.bwh.harvard.edu
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.forename: P Murali
authors.initials: PM
authors.lastname: Doraiswamy
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
authors.forename: Adam S
authors.initials: AS
authors.lastname: Fleisher
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.forename: Carl H
authors.initials: CH
authors.lastname: Sadowsky
authors.forename: Alan
authors.initials: A
authors.lastname: Carpenter
authors.forename: Mat D
authors.initials: MD
authors.lastname: Davis
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Matthew
authors.initials: M
authors.lastname: Flitter
authors.forename: Abhinay D
authors.initials: AD
authors.lastname: Joshi
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Clark
authors.forename: Michael
authors.initials: M
authors.lastname: Grundman
authors.forename: Mark A
authors.initials: MA
authors.lastname: Mintun
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Skovronsky
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pontecorvo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D005026:Ethylene Glycols; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000000981:diagnostic imaging*; D061212:Memory, Episodic; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D005026:Ethylene Glycols; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C545186:florbetapir