title: Cutting edge: lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue.
abstract: Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, we show that although primary CD4 T cell expansion is normal in RORγ-deficient mice, the persistence of memory CD4 T cells is RORγ-dependent. Furthermore, using bone marrow chimeric mice we demonstrate that LTi cells are the key RORγ-expressing cell type sufficient for memory CD4 T cell survival in the absence of persistent Ag. This effect was specific for CD4 T cells, as memory CD8 T cells survived equally well in the presence or absence of LTi cells. These data demonstrate a novel role for LTi cells, archetypal members of the innate lymphoid cell family, in supporting memory CD4 T cell survival in vivo.
authors.affiliation: Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom. d.withers@bham.ac.uk
authors.forename: David R
authors.initials: DR
authors.lastname: Withers
authors.forename: Fabrina M
authors.initials: FM
authors.lastname: Gaspal
authors.forename: Emma C
authors.initials: EC
authors.lastname: Mackley
authors.forename: Clare L
authors.initials: CL
authors.lastname: Marriott
authors.forename: Ewan A
authors.initials: EA
authors.lastname: Ross
authors.forename: Guillaume E
authors.initials: GE
authors.lastname: Desanti
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Roberts
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: White
authors.forename: Adriana
authors.initials: A
authors.lastname: Flores-Langarica
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McConnell
authors.forename: Graham
authors.initials: G
authors.lastname: Anderson
authors.forename: Peter J L
authors.initials: PJ
authors.lastname: Lane
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics; D000818:Animals; D016923:Cell Death / Q000235:genetics / Q000276:immunology; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate / Q000235:genetics; D007156:Immunologic Memory / Q000235:genetics; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000637:transplantation; D008231:Lymphopenia / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000172:deficiency / Q000235:genetics; D011828:Radiation Chimera / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology* / Q000473:pathology
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539901:Rorc protein, mouse