title: Rotavirus genotypes in children in the Basque Country (North of Spain): rapid and intense emergence of the G12[P8] genotype.
abstract: Between July 2009 and June 2011, rotavirus was detected in 507 of 4597 episodes of acute gastroenteritis in children aged <3 years in Gipuzkoa (Basque Country, Spain), of which the G-type was determined in 458 (90·3%). During the annual seasonal epidemic of 2010-2011, the unusual G-type 12 was predominant, causing 65% (145/223) of cases of rotavirus gastroenteritis. All the G12 strains were clustered in lineage III and were preferentially associated with P-type 8. This epidemic was characterized by broad geographical distribution (rural and urban) and, over 7 months, affected both infants and children, the most frequently affected being children between 4 and 24 months. Of children with rotavirus G12, 16% required hospital admission, the admission rate in children aged <2 years being 20·7 cases/10 000 children. The sudden emergence and predominance of G12 rotaviruses documented in this winter outbreak suggest that they may soon become a major human rotavirus genotype.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Donostia-Instituto BioDonostia, San Sebastián, Spain. gustavo.cillaeguiluz@osakidetza.net
authors.forename: G
authors.initials: G
authors.lastname: Cilla
authors.forename: M
authors.initials: M
authors.lastname: Montes
authors.forename: M
authors.initials: M
authors.lastname: Gomariz
authors.forename: M
authors.initials: M
authors.lastname: Alkorta
authors.forename: A
authors.initials: A
authors.lastname: Iturzaeta
authors.forename: E G
authors.initials: EG
authors.lastname: Perez-Yarza
authors.forename: E
authors.initials: E
authors.lastname: Perez-Trallero
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D005838:Genotype; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis*; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology; D022243:Rotavirus Vaccines / Q000235:genetics; D013030:Spain
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral; D022243:Rotavirus Vaccines