title: Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors.
abstract: Right out of the (logic) gate: Logic gates made from 3D DNA nanotetrahedra were constructed that are responsive to various ions, small molecules, and short strands of DNA. By including dynamic sequences in one or more edges of the tetrahedra, a FRET signal can be generated in the manner of AND, OR, XOR, and INH logic gates, as well as a half-adder circuit. These DNA logic gates were also applied to intracellular detection of ATP.
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pei
authors.forename: Le
authors.initials: L
authors.lastname: Liang
authors.forename: Guangbao
authors.initials: G
authors.lastname: Yao
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D000465:Algorithms; D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D007477:Ions / Q000737:chemistry; D008628:Mercury / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D007477:Ions; D000255:Adenosine Triphosphate; D004247:DNA; D008628:Mercury