title: Structural and functional analysis of cerebral basin arteries in different periods of hypertension.
abstract: Structure of arteries of different diameter in early and late periods of hypertension caused by experimental coarctation of the aorta was studied by histological and morphometric methods. Blood pressure was measured directly via catheterization of the common carotid artery and used for evaluation of hemodynamic in the cerebral basin. It was shown that the late period of hypertension is characterized by dilatation of medium arteries and constriction and increase tone of small arteries and arterioles. Comparison of blood pressure parameters with the parameters of inner diameter and thickness of the tunica media attests to progressive decrease of permissible tensile strength and initiation of rapture of the wall of small arteries and arterioles during chronic hypertension.
authors.affiliation: Department of Histology, Cytology and Embryology, Department of Pathological Anatomy with sectional course, Yaroslavl' State Medical Academy, Federal Agency for Health Care and Social Development, Russia. profang@mail.ru
authors.forename: A N
authors.initials: AN
authors.lastname: Gansburgsky
authors.forename: A V
authors.initials: AV
authors.lastname: Jaltsev
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002536:Cerebral Arteries / Q000502:physiology*; D004285:Dogs; D006973:Hypertension / Q000503:physiopathology*; D013718:Tensile Strength / Q000502:physiology