title: Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot.
abstract: The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibitingin vitrothe formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin-rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated.
authors.affiliation: Petrovsky Russian Research Center of Surgery, Russian Academy of Medical Sciences.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Morozov
authors.forename: L M
authors.initials: LM
authors.lastname: Khromykh
authors.forename: I I
authors.initials: II
authors.lastname: Dementieva
authors.forename: M A
authors.initials: MA
authors.lastname: Charnaia
authors.forename: N L
authors.initials: NL
authors.lastname: Kulikova
authors.forename: D B
authors.initials: DB
authors.lastname: Kazansky