title: Vitamin D in children with cystic fibrosis.
abstract: OBJECTIVE
  The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.
  
  
  METHODS
  PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.
  
  
  RESULTS
  The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.
  
  
  CONCLUSIONS
  A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.
authors.affiliation: Paediatric Respiratory Secretaries, Old Children's Outpatients Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK. m.j.brodlie@ncl.ac.uk
authors.forename: Malcolm
authors.initials: M
authors.lastname: Brodlie
authors.forename: William A
authors.initials: WA
authors.lastname: Orchard
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Reeks
authors.forename: Stewart
authors.initials: S
authors.lastname: Pattman
authors.forename: Helen
authors.initials: H
authors.lastname: McCabe
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Brien
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Thomas
authors.forename: David Anthony
authors.initials: DA
authors.lastname: Spencer
mesh_terms: D000293:Adolescent; D002112:Calcifediol / Q000097:blood* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D019587:Dietary Supplements; D010188:Exocrine Pancreatic Insufficiency / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D008485:Medical Audit; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002112:Calcifediol