title: Periodontal repair following implantation of beta-tricalcium phosphate with different pore structures in Class III furcation defects in dogs.
abstract: The aim of this study was to investigate the effect of the pore characteristics of β-tricalcium phosphate (β-TCP) on periodontal healing in class III furcation defects in dogs. Two types of β-TCP were prepared for grafting; 1) a tunnel pipe structure with an inner diameter of 300 μm, and 2) continuous pore structure with interconnected macropores. The furcations of thirty mandibular premolar teeth were implanted with each type of β-TCP or were left untreated as control. The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. Downgrowth of junctional epithelium in the tunnel structure group was significantly less than that in the other two groups (p<0.01). There was significantly more new bone formation and new cementum formation in the tunnel structure group than that in the other two groups (p<0.01). These findings suggested that β-TCP with a tunnel pipe structure promotes periodontal healing in class III furcation defects.
authors.affiliation: Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Kita-ku, Sapporo, Japan. water@den.hokudai.ac.jp
authors.forename: Emiko
authors.initials: E
authors.lastname: Saito
authors.forename: Akira
authors.initials: A
authors.lastname: Saito
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kuboki
authors.forename: Mariko
authors.initials: M
authors.lastname: Kimura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Honma
authors.forename: Tomomi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Kawanami
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D003739:Dental Cementum / Q000502:physiology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004285:Dogs; D004846:Epithelial Attachment / Q000254:growth & development; D005260:Female; D017823:Furcation Defects / Q000601:surgery*; D018919:Neovascularization, Physiologic; D016062:Porosity
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants; C485817:beta-tricalcium phosphate