title: The correlation between serum amyloid A and reactive oxygen metabolites in a young Mongolian population.
abstract: OBJECTIVE
  Chronic inflammation and oxidative stress are associated with lifestyle-related diseases. Research into the pathophysiology of lifestyle-related diseases is important for Mongolian people. Our study investigated the correlation among the d-ROMs test (a measure of the total oxidant capacity of blood), serum amyloid A (SAA) and high-sensitivity C-reactive protein (hs-CRP) levels in a young Mongolian population.
  
  
  METHODS
  The data, including anthropometric and biochemical markers, were collected from 78 Mongolian volunteers (male/female = 27/ 51, mean age 21 years). The correlation between the SAA and d-ROMs levels was examined, as well as the correlation between the hs-CRP and d-ROMs levels.
  
  
  RESULTS
  The SAA levels were 3.2 microg/mL (median), hs-CRP .04 mg/dL (median) and d-ROMs 309 CARR U, respectively. There was a significant and positive correlation between the SAA and d-ROMs levels (r=.40, P<.01), in addition to a significant and positive correlation between the hs-CRP and d-ROMs levels (r = .32, P < .01). These significant correlations remained independent in a multiple linear regression analysis. A subgroup analysis by sex revealed the positive correlation between the SAA and d-ROMs levels to be greater, relative to that between the hs-CRP and d-ROMs levels, particularly in the female group.
  
  
  CONCLUSIONS
  The coexistence of chronic inflammation and oxidative stress can be present even in young Mongolian people, suggesting that their coexistence may be a target of early prevention of lifestyle-related diseases. In addition, not only hs-CRP, but also SAA can be used to evaluate the relationship of oxidative stress in this population. Further studies are necessary to confirm the observed relationship.
authors.affiliation: Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan. kazukotani@jichi.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamada
authors.forename: Shuumarjav
authors.initials: S
authors.lastname: Uurtuya
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000208:ethnology; D008019:Life Style / Q000208:ethnology; D016014:Linear Models; D008297:Male; D008986:Mongolia; D017382:Reactive Oxygen Species / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D017382:Reactive Oxygen Species; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein