title: The outsiders: emerging roles of ectonucleotidases in inflammation.
abstract: Research on the biological roles of ectonucleoidases has revealed that CD73, an ecto-5 nucleotidase, plays a special role in the extracellular conversion of adenosine monophosphate to adenosine--specifically, as a checkpoint that determines whether the extracellular environment is proinflammatory (characterized by adenosine 5'-triphosphate-mediated responses) or anti-inflammatory (adenosine-mediated responses). Inactivating or inhibiting CD73 attenuates the extracellular formation of adenosine, exacerbating the severity of various inflammatory diseases. In this issue of Science Translational Medicine, Flögel and colleagues showed that CD73 can be pharmacologically exploited to convert an inactive adenosine precursor to an active, anti-inflammatory adenosine analog. In addition to attenuating inflammation associated with collagen-induced arthritis in a mouse model, this prodrug approach was site-selective, because the metabolic conversion relies on CD73, which is up-regulated in the inflammatory locus (the joint).
authors.affiliation: Department of Anesthesiology, Medical Branch, University of Texas, Galveston, TX 77555, USA. szabocsaba@aol.com
authors.forename: Csaba
authors.initials: C
authors.lastname: Szabo
authors.forename: Pal
authors.initials: P
authors.lastname: Pacher
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism*; D058908:Adenosine A2 Receptor Agonists / Q000627:therapeutic use*; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D007596:Joints / Q000187:drug effects*; D008297:Male; D011355:Prodrugs / Q000627:therapeutic use*; D043705:Receptor, Adenosine A2A / Q000378:metabolism*
chemical_list: D058908:Adenosine A2 Receptor Agonists; D011355:Prodrugs; D043705:Receptor, Adenosine A2A; D015720:5'-Nucleotidase