title: Design and synthesis of a novel ganglioside ligand for influenza A viruses.
abstract: A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses.
authors.affiliation: Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan. noharah18@yahoo.co.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Imamura
authors.forename: Maho
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Kazuya I P J
authors.initials: KI
authors.lastname: Hidari
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Komori
authors.forename: Hiromune
authors.initials: H
authors.lastname: Ando
authors.forename: Hideharu
authors.initials: H
authors.lastname: Ishida
authors.forename: Makoto
authors.initials: M
authors.lastname: Kiso
mesh_terms: D000818:Animals; D005732:Gangliosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000378:metabolism; D006801:Humans; D009980:Influenza A virus / Q000378:metabolism*; D008024:Ligands; D011485:Protein Binding; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism; D053585:Virus Attachment
chemical_list: D005732:Gangliosides; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D008024:Ligands; D011991:Receptors, Virus