title: The -2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis.
abstract: BACKGROUND
  The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene has been implicated in the susceptibility to tuberculosis (TB), but the results are not conclusive. The aim of this study is to investigate the association between the -2518A/G polymorphism in the MCP-1 gene and the risk of tuberculosis by meta-analysis.
  
  
  METHODS
  We searched Pubmed, Embase, CNKI and Wanfang databases, covering all studies until April 29(th), 2011. Statistical analyses were performed using the Revman4.2 and STATA10.0 software.
  
  
  RESULTS
  A total of 5341 cases and 6075 controls in 13 case-control studies were included in the meta-analysis. The results indicated that the GG homozygote carriers had a 67% increased risk of TB compared with the A allele carriers (GG vs. GA+AA: OR = 1.67, 95%CI = 1.25-2.23, P = 0.0006). In the subgroup analysis by ethnicity, significant elevated risks were found in Asians and Latinos, but not in Africans (GG vs. GA+AA: OR = 1.79, 95%CI = 1.19-2.70 and P = 0.005 for Asians; OR = 2.15, 95%CI = 1.32-3.51 and P = 0.002 for Latinos; OR = 1.28, 95%CI = 0.45-3.64 and P = 0.65 for Africans).
  
  
  CONCLUSIONS
  This meta-analysis suggested that the -2518A/G polymorphism of MCP-1 gene would be a risk factor for TB in Asians and Latinos, while not in Africans.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Lingjun
authors.initials: L
authors.lastname: Zeng
authors.forename: Honglang
authors.initials: H
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Fu
authors.forename: Can
authors.initials: C
authors.lastname: Tian
authors.forename: Zhangpeng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Fan
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D017422:Sequence Analysis, DNA; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics*
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2