title: Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs.
abstract: We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.
authors.affiliation: Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy, Guangzhou 510632, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Yu
authors.forename: Longfei
authors.initials: L
authors.lastname: Xia
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Gaoxiao
authors.initials: G
authors.lastname: Zhang
authors.forename: Zaijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Lang
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D029769:Camptotheca / Q000737:chemistry*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D007939:Leukemia L1210 / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C028098:10-hydroxycamptothecin; D002166:Camptothecin