title: Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii.
abstract: Two polyketides, cryptosporiopsin A (1) and hydroxypropan-2',3'-diol orsellinate (3), and a natural cyclic pentapeptide (4), together with two known compounds were isolated from the culture of Cryptosporiopsis sp., an endophytic fungus from leaves and branches of Zanthoxylum leprieurii (Rutaceae). The structures of these metabolites were elucidated on the basis of their spectroscopic and spectrometric data. Cryptosporiopsin A and the other metabolites exhibited motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola at 10-25μg/mL. In addition, the isolated compounds displayed potent inhibitory activity against mycelial growth of two other peronosporomycete phytopathogens, Pythium ultimum, Aphanomyces cochlioides and a basidiomycetous fungus Rhizoctonia solani. Weak cytotoxic activity on brine shrimp larvae was observed.
authors.affiliation: Institute for Organic and Biomolecular Chemistry, Georg-August University, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Ferdinand Mouafo
authors.initials: FM
authors.lastname: Talontsi
authors.forename: Petrea
authors.initials: P
authors.lastname: Facey
authors.forename: Michel D Kongue
authors.initials: MD
authors.lastname: Tatong
authors.forename: M
authors.initials: M
authors.lastname: Tofazzal Islam
authors.forename: Holm
authors.initials: H
authors.lastname: Frauendorf
authors.forename: Siegfried
authors.initials: S
authors.lastname: Draeger
authors.forename: Andreas von
authors.initials: Av
authors.lastname: Tiedemann
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000818:Animals; D044744:Aphanomyces / Q000187:drug effects* / Q000254:growth & development; D001156:Artemia / Q000187:drug effects*; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship; D032106:Zanthoxylum / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010456:Peptides, Cyclic; D061065:Polyketides