title: Retrospective analysis of outcome data with regards to the use of Phisio®-, Bioline®- or Softline®-coated cardiopulmonary bypass circuits in cardiac surgery.
abstract: BACKGROUND
  Numerous cardiopulmonary bypass circuits with various coatings designed to reduce the inflammatory response and to provide better hemocompatibility are available. The aim of this study was to compare the effect of phosphorylcholine-coated, albumin-heparin-coated and synthetic polymer-coated perfusion tubing systems on patient outcome.
  
  
  METHODS
  We performed a retrospective database review of elective patients between January 1st 2010 and December 31st 2010. Demographics, preoperative, operative, postoperative data and follow-up were collected and statistically analysed.
  
  
  RESULTS
  We identified 201 patients and formed three groups: Group 1 with phosphorylcholine coating (n=133), Group 2 with albumin-heparin coating (n=32) and Group 3 synthetic polymer coating (n=36). Mean age was 68 ± 11 years, additive Euroscore 5.8 ± 2.7. In-hospital outcomes were comparable between the groups without statistically significant differences. The overall 30-day and 1-year late survival were 98.5% and 96.7 ± 1.9%, respectively.
  
  
  CONCLUSIONS
  Our findings suggest that in-hospital and follow-up outcomes are comparable in cardiac surgery patients after using either phosphorylcholine-coated, albumin-heparin-coated or synthetic polymer-coated circuits during cardiopulmonary bypass.
authors.affiliation: Clinic of Cardiac and Vascular Surgery, University Hospital Zurich, Zurich, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Reser
authors.forename: B
authors.initials: B
authors.lastname: Seifert
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: T
authors.initials: T
authors.lastname: Dreizler
authors.forename: P
authors.initials: P
authors.lastname: Hasenclever
authors.forename: V
authors.initials: V
authors.lastname: Falk
authors.forename: C
authors.initials: C
authors.lastname: Starck
mesh_terms: D000368:Aged; D000418:Albumins / Q000737:chemistry; D000925:Anticoagulants / Q000737:chemistry; D006348:Cardiac Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005260:Female; D006493:Heparin / Q000737:chemistry; D006801:Humans; D008297:Male; D010767:Phosphorylcholine / Q000737:chemistry; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000418:Albumins; D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D010767:Phosphorylcholine; D006493:Heparin