title: Transformation and biodegradation of 1,2,3-trichloropropane (TCP).
abstract: OBJECTIVE
  1,2,3-Trichloropropane (TCP) is a persistent groundwater pollutant and a suspected human carcinogen. It is also is an industrial chemical waste that has been formed in large amounts during epichlorohydrin manufacture. In view of the spread of TCP via groundwater and its toxicity, there is a need for cheap and efficient technologies for the cleanup of TCP-contaminated sites. In situ or on-site bioremediation of TCP is an option if biodegradation can be achieved and stimulated. This paper presents an overview of methods for the remediation of TCP-contaminated water with an emphasis on the possibilities of biodegradation.
  
  
  CONCLUSIONS
  Although TCP is a xenobiotic chlorinated compound of high chemical stability, a number of abiotic and biotic conversions have been demonstrated, including abiotic oxidative conversion in the presence of a strong oxidant and reductive conversion by zero-valent zinc. Biotransformations that have been observed include reductive dechlorination, monooxygenase-mediated cometabolism, and enzymatic hydrolysis. No natural organisms are known that can use TCP as a carbon source for growth under aerobic conditions, but anaerobically TCP may serve as electron acceptor. The application of biodegradation is hindered by low degradation rates and incomplete mineralization. Protein engineering and genetic modification can be used to obtain microorganisms with enhanced TCP degradation potential.
authors.affiliation: Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Ghufrana
authors.initials: G
authors.lastname: Samin
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001673:Biodegradation, Environmental; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D060847:Metabolic Engineering / Q000379:methods; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D015202:Protein Engineering; D014873:Water Pollutants / Q000378:metabolism* / Q000633:toxicity; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
chemical_list: D002273:Carcinogens; D014873:Water Pollutants; C009536:1,2,3-trichloropropane; D015032:Zinc; D011407:Propane