title: [Pulmonary hemorrhage associated with celiac disease].
abstract: Idiopathic pulmonary hemosiderosis is a severe and potentially fatal disease characterized by recurrent episodes of alveolar hemorrhage, hemoptysis, and anemia. His association with celiac disease, described as Lane- Hamilton syndrome, could be due to the fact that both entities share a common pathogenic immune pathway. We report two patients of 13 years who consulted for hemoptysis and severe anemia that had not responded to immunosuppressive treatment with pulses of methyl prednisolone, oral meprednisone and hydroxychloroquine. Although both children highlight the absence of gastrointestinal symptoms at the time of consultation, the dosage of anti-endomysial and anti-transglutaminase antibodies was positive and biopsy confirmed the presence of intestinal enteropathy. It is emphasized that in patients with diffuse alveolar hemorrhage, even in the absence of gastrointestinal symptoms, the concomitant presence of celiac disease should be evaluated. If celiac disease is present, the incorporation of a gluten-free diet helps to control the symptoms, allows reducing the immunosuppressive treatment and improves the clinical course of both entities.
authors.affiliation: Centro Respiratorio, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad autónoma de Buenos Aires, Argentina.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Testa
authors.forename: Alberto
authors.initials: A
authors.lastname: Maffey
authors.forename: Alejandro
authors.initials: A
authors.lastname: Colom
authors.forename: Luis
authors.initials: L
authors.lastname: Agüero
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rogé
authors.forename: María Sol
authors.initials: MS
authors.lastname: Andrewartha
authors.forename: Alejandro
authors.initials: A
authors.lastname: Teper
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D002446:Celiac Disease / Q000175:diagnosis*; D006469:Hemoptysis / Q000209:etiology; D006470:Hemorrhage / Q000175:diagnosis*; D006486:Hemosiderosis / Q000175:diagnosis*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis*; D008297:Male; D013577:Syndrome; D000097545:Hemosiderosis, Pulmonary