title: Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor.
abstract: Spherical carbonate apatite (CO3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO3Ap microspheres with high uniformity could not be achieved without using a core. Solid CO3Ap microspheres were obtained using a calcite core whereas hollow CO3Ap microspheres were obtained using a NaCl core. The obtained microsphere was identified as B-type CO3Ap by Fourier transform infrared analysis and the carbonate content was approximately 7-8 wt% regardless of the type of core used for sample preparation. The mechanical strength of both the solid and hollow CO3Ap microspheres was sufficient for practical use as a bone substitute.
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sunouchi
authors.forename: Kanji
authors.initials: K
authors.lastname: Tsuru
authors.forename: Michito
authors.initials: M
authors.lastname: Maruta
authors.forename: Giichiro
authors.initials: G
authors.lastname: Kawachi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Terada
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D001031:Apatites / Q000138:chemical synthesis* / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002119:Calcium Carbonate / Q000737:chemistry; D008863:Microspheres; D016062:Porosity; D012965:Sodium Chloride / Q000737:chemistry
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D012965:Sodium Chloride; C030782:carboapatite; D002119:Calcium Carbonate