title: Recognition of bacterial infection by innate immune sensors.
abstract: Microbial challenges to the host initiate an array of defense processes through the activation of innate and adaptive immunity. Innate immunity consists of sensors or pattern-recognition receptors (PRRs) that are expressed on immune and non-immune cells and sense conserved pathogen-derived molecules or pathogen-associated molecular patterns (PAMPs) in various compartments of the host cells. Recognition of the PAMPs by PRRs triggers antimicrobial effector responses via the induction of proinflammatory cytokines and type I IFNs. Several families of PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs), and DNA sensors and their respective PAMPs have been well studied in innate immunity and host defense. Here, we review the recent findings on bacterial recognition by TLRs and NLRs and the signaling pathways activated by these sensors.
authors.affiliation: Laboratory of Immunology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India.
authors.forename: Sushil
authors.initials: S
authors.lastname: Kumar
authors.forename: Harshad
authors.initials: H
authors.lastname: Ingle
authors.forename: Durbaka Vijaya Raghava
authors.initials: DV
authors.lastname: Prasad
authors.forename: Himanshu
authors.initials: H
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D051192:Receptors, Pattern Recognition