title: Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm.
abstract: Despite improvements in the clinical management of aneurysmal subarachnoid haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single most important cause of morbidity and mortality in those patients who survive the initial bleed. The pathological mechanisms underlying DCI are still unclear and the calcium channel blocker nimodipine remains the only therapeutic intervention proven to improve functional outcomes after SAH. The recent failure of the drug clazosentan to improve functional outcomes despite reducing vasoconstriction has moved the focus of research into DCI away from cerebral artery constriction towards a more multifactorial aetiology. Novel pathological mechanisms have been suggested, including damage to cerebral tissue in the first 72 h after aneurysm rupture ('early brain injury'), cortical spreading depression, and microthrombosis. A greater understanding of the significance of these pathophysiological mechanisms and potential genetic risk factors is required, if new approaches to the prophylaxis, diagnosis, and treatment of DCI are to be developed. Furthermore, objective and reliable biomarkers are needed for the diagnosis of DCI in poor grade SAH patients requiring sedation and to assess the efficacy of new therapeutic interventions. The purpose of this article is to appraise these recent advances in research into DCI, relate them to current clinical practice, and suggest potential novel avenues for future research.
authors.affiliation: Nuffield Division of Anaesthetics and FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK. mrowland@fmrib.ox.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Rowland
authors.forename: G
authors.initials: G
authors.lastname: Hadjipavlou
authors.forename: M
authors.initials: M
authors.lastname: Kelly
authors.forename: J
authors.initials: J
authors.lastname: Westbrook
authors.forename: K T S
authors.initials: KT
authors.lastname: Pattinson
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology; D002545:Brain Ischemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D003097:Collateral Circulation; D006706:Homeostasis; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D018384:Oxidative Stress; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D014661:Vasoconstriction; D020301:Vasospasm, Intracranial / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D001057:Apolipoproteins E; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors