title: Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
abstract: Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants.
authors.affiliation: Department of Global Health, University of Washington, Seattle, Washington, USA. jslyker@u.washington.edu
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Slyker
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Rowland-Jones
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.forename: Marie
authors.initials: M
authors.lastname: Reilly
authors.forename: Barbra
authors.initials: B
authors.lastname: Richardson
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Emery
authors.forename: Ann
authors.initials: A
authors.lastname: Atzberger
authors.forename: Dorothy
authors.initials: D
authors.lastname: Mbori-Ngacha
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Lohman-Payne
authors.forename: Grace C
authors.initials: GC
authors.lastname: John-Stewart
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000032:analysis; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D060085:Coinfection; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D007630:Kenya; D008213:Lymphocyte Activation; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D019562:Viral Load; D019014:fas Receptor / Q000096:biosynthesis
chemical_list: D006684:HLA-DR Antigens; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; D051997:ADP-ribosyl Cyclase 1