title: Recurrent bilateral metatarsal "stress-and-insufficiency" fractures in a levodopa-treated young woman with Parkinson's disease.
abstract: Levodopa treatment of Parkinson's disease is very effective, but many types of adverse events can complicate the disease course, especially dyskinesias. As reported by Lee et al. (Calcif Tissue Int 86:132-41, 2010), levodopa intake is associated with increased homocysteinemia that is known to be linked to poorer bone quality and, consequently, osteoporotic fractures. Herein, we report the case of a young woman who suffered recurrent metatarsal fractures in the context of levodopa-treated early-onset Parkinson's disease.
authors.affiliation: Service de Rhumatologie, CHU Hôpitaux de Rouen, Hôpital de Bois-Guillaume, 147 av du Mal Juin, 76230 Bois-Guillaume Cedex, France. mathieu.verdet@chu-rouen.fr
authors.forename: M
authors.initials: M
authors.lastname: Verdet
authors.forename: J
authors.initials: J
authors.lastname: Nicolau
authors.forename: R
authors.initials: R
authors.lastname: Lefaucheur
authors.forename: D
authors.initials: D
authors.lastname: Maltête
authors.forename: S
authors.initials: S
authors.lastname: Derrey
authors.forename: A
authors.initials: A
authors.lastname: Daragon
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D005260:Female; D015775:Fractures, Stress / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008682:Metatarsal Bones / Q000000981:diagnostic imaging / Q000293:injuries*; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000139:chemically induced / Q000000981:diagnostic imaging; D010300:Parkinson Disease / Q000188:drug therapy*; D011859:Radiography; D012008:Recurrence
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa