title: Hydrogels incorporating GdDOTA: towards highly efficient dual T1/T2 MRI contrast agents.
abstract: Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTA NPs) exhibited high relaxivity (r(1) =101.7 s(-1) mM(-1) per Gd(3+) ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T(1)/T(2) dual-mode contrast agent was studied in C6 cells.
authors.affiliation: Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne Ardenne, UFR de Pharmacie, Reims, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Courant
authors.forename: Valérie Gaëlle
authors.initials: VG
authors.lastname: Roullin
authors.forename: Cyril
authors.initials: C
authors.lastname: Cadiou
authors.forename: Maïté
authors.initials: M
authors.lastname: Callewaert
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Andry
authors.forename: Christophe
authors.initials: C
authors.lastname: Portefaix
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: de Goltstein
authors.forename: Marc
authors.initials: M
authors.lastname: Port
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Luce Vander
authors.initials: LV
authors.lastname: Elst
authors.forename: Robert
authors.initials: R
authors.lastname: Muller
authors.forename: Michaël
authors.initials: M
authors.lastname: Molinari
authors.forename: Françoise
authors.initials: F
authors.lastname: Chuburu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry; D051381:Rats
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D020100:Hydrogels; D009942:Organometallic Compounds; D011134:Polysaccharides; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate