title: Influence of dentures in the initial occurrence site on the prognosis of bisphosphonate-related osteonecrosis of the jaws: a retrospective study.
abstract: OBJECTIVE
  This retrospective cohort study was conducted to investigate the influence of wearing dentures in the initial occurrence site of bisphosphonate-related osteonecrosis of the jaws (BRONJ).
  
  
  METHODS
  A questionnaire regarding the prevalence, therapy, and outcome of jawbone lesions during 2006-08 was mailed to 248 medical institutions with an oral and maxillofacial surgery department in Japan.
  
  
  RESULTS
  Ninety-nine patients wearing dentures had significantly shorter duration until occurrence than 151 patients not wearing dentures. In addition, remission of BRONJ affecting the mandibular canine and premolar region in denture-wearing patients was significantly more difficult. Poor oral hygiene status was found to affect significantly the prognosis of BRONJ in denture-wearing patients. Alcohol habit also delayed remission, but high body mass index promoted remission.
  
  
  CONCLUSIONS
  Wearing a denture in the initial occurrence site of BRONJ was shown to influence the prognosis of BRONJ, especially in mandibular denture-wearing patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Mutuki
authors.initials: M
authors.lastname: Kawabe
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kimura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kurita
authors.forename: Jinichi
authors.initials: J
authors.lastname: Fukuta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Urade
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D001641:Bicuspid / Q000473:pathology; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000473:pathology* / Q000601:surgery; D015992:Body Mass Index; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D002908:Chronic Disease; D015331:Cohort Studies; D003481:Cuspid / Q000473:pathology; D003824:Denture, Complete; D003829:Denture, Partial; D003778:Dentures; D004164:Diphosphonates / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000473:pathology / Q000601:surgery; D009910:Oral Hygiene; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates