title: TXNIP switches tracks toward a terminal UPR.
abstract: During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.
authors.affiliation: Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
authors.forename: Tracy G
authors.initials: TG
authors.lastname: Anthony
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Wek