title: Amygdala-gustatory insular cortex connections and taste neophobia.
abstract: To examine whether communication between the amygdala and gustatory insular cortex (GC) is required for normal performance of taste neophobia, three experiments were conducted. In Experiment 1, rats with asymmetric unilateral lesions of the basolateral amygdala (BLA) and the GC displayed elevated intake of a novel saccharin solution relative to control subjects. However, an attenuation of neophobia was not found following asymmetric unilateral lesions of the GC and medial amygdala (MeA; Experiment 2) or of the MeA and BLA (Experiment 3). This pattern of results indicates that the BLA and GC functionally interact during expression of taste neophobia and that the MeA functionally interacts with neither the BLA nor the GC. Research is needed to further characterize the nature of the involvement of the MeA in taste neophobia and to determine the function of the BLA-GC interaction during exposure to a new taste.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA. jlin2@uic.edu
authors.forename: Jian-You
authors.initials: JY
authors.lastname: Lin
authors.forename: Steve
authors.initials: S
authors.lastname: Reilly
mesh_terms: D000679:Amygdala / Q000293:injuries / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000293:injuries / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005239:Fear / Q000523:psychology*; D005508:Food Deprivation; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin; D013649:Taste / Q000502:physiology*
chemical_list: D012439:Saccharin