title: Bartonella henselae-mediated disease in solid organ transplant recipients: two pediatric cases and a literature review.
abstract: Bartonella henselae, the etiologic agent of cat-scratch disease, causes a well-defined, self-limited syndrome of fever and regional lymphadenopathy in immunocompetent hosts. In immunocompromised hosts, however, B. henselae can cause severe disseminated disease and pathologic vasoproliferation known as bacillary angiomatosis (BA) or bacillary peliosis. BA was first recognized in patients infected with human immunodeficiency virus. It has become more frequently recognized in solid organ transplant (SOT) recipients, but reports of pediatric cases remain rare. Our review of the literature revealed only one previously reported case of BA in a pediatric SOT recipient. We herein present 2 pediatric cases, one of which is the first reported case of BA in a pediatric cardiac transplant recipient, to our knowledge. In addition, we review and summarize the literature pertaining to all cases of B. henselae-mediated disease in SOT recipients.
authors.affiliation: Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Rostad
authors.forename: A K
authors.initials: AK
authors.lastname: McElroy
authors.forename: J A
authors.initials: JA
authors.lastname: Hilinski
authors.forename: M P
authors.initials: MP
authors.lastname: Thompson
authors.forename: C P
authors.initials: CP
authors.lastname: Drew
authors.forename: A M
authors.initials: AM
authors.lastname: Denison
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: W T
authors.initials: WT
authors.lastname: Mahle
authors.forename: J
authors.initials: J
authors.lastname: Rogers
authors.forename: C R
authors.initials: CR
authors.lastname: Abramowsky
authors.forename: B
authors.initials: B
authors.lastname: Shehata
mesh_terms: D016917:Angiomatosis, Bacillary / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018416:Bartonella henselae / Q000302:isolation & purification*; D002372:Cat-Scratch Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D002415:Cats; D002648:Child; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents