title: Synthetic studies toward (+)-cortistatin A.
abstract: We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis.
authors.affiliation: Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Wang
authors.forename: Mingji
authors.initials: M
authors.lastname: Dai
authors.forename: Peter K
authors.initials: PK
authors.lastname: Park
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky