title: Serum total protein, albumin and advanced oxidation protein products (AOPP)--implications in oral squamous cell carcinoma.
abstract: BACKGROUND
  The role of oxygen free radicals in the initiation, promotion and progression of carcinogenesis and the protective role of anti-oxidant defenses have been the subject of much speculation in the recent past with conflicting reports in the literature.
  
  
  OBJECTIVE
  The aim of this study was to measure the concentration/levels of serum total proteins, albumin and advanced oxidation protein products as markers of oxidative stress in sera of patients with an oral pre-cancerous lesion and frank oral cancer.
  
  
  METHODS
  The study consisted of sera analysis of 30 new patients of histologically proven well-differentiated, oral squamous cell carcinoma and 10 patients, clinically diagnosed with a potentially malignant epithelial lesion, speckled leukoplakia, aged between 40 to 60 years, in addition to 25 healthy controls. One way analyses of variance were used to test the difference between groups. The normality of data was checked before the statistical analysis was performed.
  
  
  RESULTS
  The study revealed variations in sera levels of albumin and advanced oxidation protein products to be statistically significant (p<0.001).
  
  
  CONCLUSIONS
  The results obtained emphasize the need for more studies with larger sample sizes to be conducted before a conclusive role could be drawn in favour of sera levels of total protein, albumin and advanced oxidation protein products as markers of diagnostic significance and of the transition from the various oral pre-cancerous lesions and conditions into frank oral cancers.
authors.affiliation: Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India. id-singhabhishek.rims@gmail.com
authors.forename: Abhishek Singh
authors.initials: AS
authors.lastname: Nayyar
authors.forename: Mubeen
authors.initials: M
authors.lastname: Khan
authors.forename: K R
authors.initials: KR
authors.lastname: Vijayalakshmi
authors.forename: B
authors.initials: B
authors.lastname: Suman
authors.forename: H C
authors.initials: HC
authors.lastname: Gayitri
authors.forename: M
authors.initials: M
authors.lastname: Anitha
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007972:Leukoplakia, Oral / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000175:diagnosis*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D017382:Reactive Oxygen Species; D012709:Serum Albumin