title: Setting an agenda for comparative effectiveness systematic reviews in CKD care.
abstract: Systematic reviews comparing the effectiveness of strategies to prevent, detect, and treat chronic kidney disease are needed to inform patient care. We engaged stakeholders in the chronic kidney disease community to prioritize topics for future comparative effectiveness research systematic reviews. We developed a preliminary list of suggested topics and stakeholders refined and ranked topics based on their importance. Among 46 topics identified, stakeholders nominated 18 as 'high' priority. Most pertained to strategies to slow disease progression, including: (a) treat proteinuria, (b) improve access to care, (c) treat hypertension, (d) use health information technology, and (e) implement dietary strategies. Most (15 of 18) topics had been previously studied with two or more randomized controlled trials, indicating feasibility of rigorous systematic reviews. Chronic kidney disease topics rated by stakeholders as 'high priority' are varied in scope and may lead to quality systematic reviews impacting practice and policy.
authors.forename: Deidra C
authors.initials: DC
authors.lastname: Crews
authors.forename: Raquel C
authors.initials: RC
authors.lastname: Greer
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Fadrowski
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Choi
authors.forename: David
authors.initials: D
authors.lastname: Doggett
authors.forename: Jodi B
authors.initials: JB
authors.lastname: Segal
authors.forename: Kemi A
authors.initials: KA
authors.lastname: Fawole
authors.forename: Pammie R
authors.initials: PR
authors.lastname: Crawford
authors.forename: L Ebony
authors.initials: LE
authors.lastname: Boulware
mesh_terms: D057186:Comparative Effectiveness Research; D019317:Evidence-Based Medicine; D006301:Health Services Needs and Demand / Q000458:organization & administration*; D006302:Health Services Research / Q000379:methods*; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000379:methods*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome; D014481:United States