title: [Impact of metabolic syndrome on cardio-cerebral vascular events in pre-hypertensive population].
abstract: OBJECTIVE
  This study investigated the impact of metabolic syndrome on the development of cardio-cerebral vascular (CVD) events in a pre-hypertensive population.
  
  
  METHODS
  The data used in this prospective study was derived from the Kailuan study cohort (n = 101 510). Prehypertension was diagnosed in 29 968 (mean age: 50 ± 9 years and 23 744 males) individuals by the JNC VII criteria and these subjects were further classified into metabolic syndrome positive (MS+, n = 3447) and MS negative (MS-, n = 26 521) groups according to the modified 2004 Chinese Diabetes Society criteria. Subjects were followed up for 38 - 53 (mean 47 ± 5) months and first-ever CVD events were recorded. Baseline anthropometric and laboratory features were obtained by physical examination from June 2006 to October 2007 and the last follow-up day was December 31, 2010. Multivariable Cox proportional hazards regression models were used to analyze the risk factors of first-ever CVD events.
  
  
  RESULTS
  There were 354 CVD events during follow up. The incidences of CVD events (1.80% vs. 1.28%) and cerebral infarction (1.10% vs. 0.57%) were significantly higher in the MS+ group than in the MS- group (all P < 0.05). After adjustment for other established CVD risk factors, the hazards ratio was 1.45 (95%CI: 1.10 - 1.92) for total CVD events and 1.84 (95%CI: 1.27 - 2.67) for cerebral infarction events in MS+ group.
  
  
  CONCLUSIONS
  In this cohort, metabolic syndrome is linked with increased risk for CVD events.
authors.affiliation: Department of Cardiology, Hebei United University, Tangshan, China. drwusl@163.com
authors.forename: Shou-ling
authors.initials: SL
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chun-yu
authors.initials: CY
authors.lastname: Ruan
authors.forename: Qi
authors.initials: Q
authors.lastname: Tian
authors.forename: Cheng
authors.initials: C
authors.lastname: Jin
authors.forename: Jin-feng
authors.initials: JF
authors.lastname: Li
authors.forename: Yu-yan
authors.initials: YY
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Ji-wen
authors.initials: JW
authors.lastname: Zhong
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D002561:Cerebrovascular Disorders / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D058246:Prehypertension / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors