title: The role of interleukin-1 in allergy-related disorders.
abstract: OBJECTIVE
  Interleukin-1β (IL-1β) is a potent proinflammatory cytokine, which is involved in many inflammatory conditions including autoinflammatory and allergic disorders. This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders.
  
  
  RESULTS
  In autoinflammatory as well as allergic diseases such as contact hypersensitivity, atopic dermatitis and bronchial asthma, dysfunctional inflammasome processing has been demonstrated to account for IL-1β-induced inflammation. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models of urticarial autoinflammatory diseases as well as common allergic disorders.
  
  
  CONCLUSIONS
  The recent findings support a crucial role for IL-1β and inflammasome components in a variety of allergy-related disorders.
authors.affiliation: Autoinflammation Reference Center Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Karoline
authors.initials: K
authors.lastname: Krause
authors.forename: Martin
authors.initials: M
authors.lastname: Metz
authors.forename: Michael
authors.initials: M
authors.lastname: Makris
authors.forename: Torsten
authors.initials: T
authors.lastname: Zuberbier
authors.forename: Marcus
authors.initials: M
authors.lastname: Maurer
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology* / Q000503:physiopathology*; D058847:Inflammasomes; D007249:Inflammation / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D014581:Urticaria / Q000276:immunology / Q000503:physiopathology
chemical_list: D058847:Inflammasomes; D053583:Interleukin-1beta