title: Bone metabolism biomarkers, body weight, and bone age in healthy Brazilian male adolescents.
abstract: Eighty-seven male volunteers were grouped according to bone age (BA): 10-12 years (n=25), 13-15 years (n=36), and 16-18 years (n=26), and the following were recorded for each: weight (kg), height (m), BMI (kg/m(2)), calcium intake from three 24-h food recalls (mg/day), puberty evaluation by Tanner stages, bone biomarker (BB) evaluation, serum osteocalcin (OC), bone alkaline phosphatase (BAP), carboxyterminal telopeptide (S-CTx), and bone mineral density (BMD) evaluations by dual-energy X-ray absorptiometry (g x cm(2)) in the lumbar spine, proximal femur, and the whole body. BBs showed similar behaviors, and very high median values were observed for individuals aged 13-15 years (BAP = 155.50 IU/L, OC = 41.63 ng/mL, S-CT x =2.09 ng/mL). Lower median BB values were observed with advancing BA between 16 and 18 years (BA P =79.80 IU/L, O C =27.80 ng/mL, S-CT x =1.65 ng/mL). Stepwise multiple regression analysis showed body weight associated with BA as independent variables with greater determination power for S-CTx (r(2) = 0.40) and OC (r(2)=0.21). For BAP, stepwise analysis showed body weight and whole-body BMD (r(2) = 0.34). All predictive models showed significance ( p < 0.01). A high turnover for both bone formation and resorption biomarkers, particularly from 13 to 15 years of BA, were observed along with very low values in the 16-18 age range. Weight and BA were significant in determining predictive equations of OC and of S-CTx, whereas for BAP, weight and BMD of full body were selected.
authors.affiliation: Department of Physical Education, University of North Parani, Parani, Brazil.
authors.forename: Carla Cristiane
authors.initials: CC
authors.lastname: da Silva
authors.forename: Cilmery Suemi
authors.initials: CS
authors.lastname: Kurokawa
authors.forename: Hong Si
authors.initials: HS
authors.lastname: Nga
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Moretto
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Dalmas
authors.forename: Tamara Beres Lederer
authors.initials: TB
authors.lastname: Goldberg
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D001846:Bone Development / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D001938:Brazil; D006801:Humans; D008297:Male; D011627:Puberty / Q000378:metabolism*; D012016:Reference Values; D055815:Young Adult
chemical_list: D015415:Biomarkers