title: Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer.
abstract: Cigarette smoking is the main cause of chronic obstructive pulmonary disease and lung cancer. The present study was aimed to explore the chemopreventive effect of ursolic acid (UA) on these diseases. In the CSE treated normal human bronchial epithelial cell model, UA alleviated cytotoxicity caused by CSE, recovered the intracellular redox balance, and relieved the stimulation of external deleterious factors as well. UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway. Moreover, UA inhibited lung cancer development in the model established by A549 cells in nude mice in vivo. For the first time, our results indicate that UA could be developed as a potential lung cancer chemopreventive agent.
authors.affiliation: Key Laboratory of Delivery Systems of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu 210028, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Liu
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Tan
authors.forename: Luan
authors.initials: L
authors.lastname: Shu
authors.forename: Hanyan
authors.initials: H
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.forename: Ping
authors.initials: P
authors.lastname: Jin
authors.forename: Siming
authors.initials: S
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Jia
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D055745:Bronchioles / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D018890:Chemoprevention; D003520:Cyclophosphamide / Q000494:pharmacology; D019610:Cytoprotection; D004249:DNA Damage; D004847:Epithelial Cells / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D050217:Metabolic Detoxication, Phase II; D051379:Mice; D008819:Mice, Nude; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana / Q000009:adverse effects*; D014315:Triterpenes / Q000494:pharmacology*; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays; D000097245:Ursolic Acid
chemical_list: D016588:Anticarcinogenic Agents; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D005978:Glutathione; D005982:Glutathione Transferase; D007770:L-Lactate Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D051267:NF-E2-Related Factor 2; D012906:Smoke; D014315:Triterpenes; D000097245:Ursolic Acid; C495635:NFE2L2 protein, human; C447479:NQO1 protein, human