title: Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.
abstract: License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.
authors.affiliation: University of California, Berkeley, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-0912, USA.
authors.forename: J P Michael
authors.initials: JP
authors.lastname: Motion
authors.forename: Juliane
authors.initials: J
authors.lastname: Nguyen
authors.forename: Francis C
authors.initials: FC
authors.lastname: Szoka
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003593:Cytoplasm / Q000378:metabolism*; D015700:HIV Envelope Protein gp41 / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D010455:Peptides / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry / Q000378:metabolism*; D014162:Transfection
chemical_list: D015700:HIV Envelope Protein gp41; D008081:Liposomes; D010455:Peptides; D010744:Phosphoric Monoester Hydrolases