title: Clostridium histolyticum collagenase in the treatment of Dupuytren's contracture.
abstract: Dupuytren's disease is a common, costly and recurrent health issue. This review compares Clostridium histolyticum collagenase with current operative treatments. Collagenase management is an effective non-surgical alternative associated with lower risks of serious adverse events, but higher incidence of non-serious adverse events.
authors.affiliation: Hand Surgery Unit, Welsh Centre for Burns and Plastic Surgery, Morrison Hospital, Swansea SA6 6NL, UK.
authors.forename: Ernest
authors.initials: E
authors.lastname: Azzopardi
authors.forename: Dean E
authors.initials: DE
authors.lastname: Boyce
mesh_terms: D047009:Hathewaya histolytica / Q000201:enzymology*; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D015552:Injections, Intralesional; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010447:Peptide Hydrolases / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010447:Peptide Hydrolases; D003012:Microbial Collagenase