title: Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.
abstract: The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.
authors.affiliation: Agricultural Research Institute, Council of Agriculture Executive, Taichung, Taiwan 40512.
authors.forename: Chia-Hsin
authors.initials: CH
authors.lastname: Huang
authors.forename: Mei-Fen
authors.initials: MF
authors.lastname: Chen
authors.forename: Hsien-Hui
authors.initials: HH
authors.lastname: Chung
authors.forename: Juei-Tang
authors.initials: JT
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D031584:Hibiscus / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007333:Insulin Resistance / Q000276:immunology; D008297:Male; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D001547:Benzaldehydes; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; C069665:syringaldehyde