title: Multiple metastatic renal cell carcinoma isolated to pancreas.
abstract: Renal cell carcinoma (RCC) metastases to the pancreas are reported to be rare. Isolated multiple pancreatic metastases are even rarer. We report a 68-year-old asymptomatic male patient who presented with multiple metastatic nodular lesions in the pancreas demonstrated by computerized tomography 3.5 years after radical nephrectomy performed for clear cell RCC. Spleen-preserving total pancreatectomy was performed. Gross examination revealed five well-demarcated tumoral nodules in the head, body and tail of the pancreas. Histopathological examination revealed clusters of epithelial clear cells, immunohistochemically positive for CD10 and vimentin, and negative for CK19 and chromogranin, supporting a diagnosis of metastatic RCC. The patient has remained well at 29 months post-resection, in agreement with recent experience that radical resection for multiple isolated metastatic nodular lesions can achieve improved survival and better quality of life.
authors.affiliation: Department of Pathology, Başkent University Faculty of Medicine, Istanbul, Turkey. cemcomunoglu@gmail.com
authors.forename: Cem
authors.initials: C
authors.lastname: Comunoğlu
authors.forename: Gülüm
authors.initials: G
authors.lastname: Altaca
authors.forename: Ebru
authors.initials: E
authors.lastname: Demiralay
authors.forename: Gökhan
authors.initials: G
authors.lastname: Moray
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009392:Nephrectomy; D015260:Neprilysin / Q000378:metabolism; D010179:Pancreas / Q000473:pathology / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D011788:Quality of Life; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D014746:Vimentin; D015260:Neprilysin