title: Plasma resistin levels are associated with insulin resistance in older Japanese men from a rural village.
abstract: BACKGROUND
  The role of resistin in the pathophysiology of insulin resistance in human is controversial and different in men and women. Thus, the discrepancy among previous reports may be resolved by gender-specific analysis of a large number of participants.
  
  
  METHODS
  From a single community, we recruited 746 men (mean age, 60±14 years) and 1033 women (63±12 years) during their annual health examination. We investigated whether plasma resistin levels are associated with insulin resistance evaluated by homeostasis of model assessment of insulin resistance (HOMA-IR) according to gender.
  
  
  RESULTS
  Resistin levels were significantly correlated with HOMA-IR in men, but not in women. Analysis of covariance showed that two regression lines were significantly different (F=9.941, P=0.002). Multiple linear regression analyses for resistin showed that the resistin levels (β=0.124, P<0.001) were independently and significantly associated with HOMA-IR as well as body mass index (BMI), alcohol consumption, smoking status, uric acid, γ-glutamyltransferase (GGT), and high molecular weight (HMW) adiponectin only in men and not in women. The interaction between gender and resistin level (F=11.50, P<0.001) was also a significant and independent determinant for HOMA-IR as well as gender, BMI, alcohol consumption, smoking status, uric acid, GGT, HMW adiponectin, and resistin.
  
  
  CONCLUSIONS
  These results suggest that plasma resistin levels are associated with insulin resistance in older Japanese men.
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@yahoo.co.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D052243:Resistin / Q000097:blood*; D012424:Rural Population / Q000706:statistics & numerical data*; D012737:Sex Factors
chemical_list: D008055:Lipids; D052243:Resistin