title: Risk stratification in hypertrophic cardiomyopathy: time for renewal?
abstract: Systematic clinical assessment and careful monitoring of patients with hypertrophic cardiomyopathy (HCM) can be used to identify a cohort of patients that benefit from medical intervention and almost certainly improve long-term outcomes. One of the major limitations of the current approach is a lack of predictive power of individual risk factors, which means that many patients receive therapy. The aim of this review is to highlight other aspects of the disease, assessed using old and new medical technologies, that appear to provide new prognostic information. The hope for the future is that their incorporation in new risk algorithms will improve treatment for all HCM patients with the disease, irrespective of their vulnerability to adverse complications.
authors.affiliation: Department of Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy. gpacile@tin.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pacileo
authors.forename: Gemma
authors.initials: G
authors.lastname: Salerno
authors.forename: Rita
authors.initials: R
authors.lastname: Gravino
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
authors.forename: Perry Mark
authors.initials: PM
authors.lastname: Elliott
mesh_terms: D001281:Atrial Fibrillation / Q000209:etiology / Q000628:therapy; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D003326:Coronary Circulation; D003661:Decision Support Techniques; D018450:Disease Progression; D005355:Fibrosis; D020022:Genetic Predisposition to Disease; D006801:Humans; D008833:Microcirculation; D009154:Mutation; D009206:Myocardium / Q000473:pathology; D010641:Phenotype; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016277:Ventricular Function, Left; D014694:Ventricular Outflow Obstruction / Q000209:etiology / Q000628:therapy