title: Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD.
abstract: BACKGROUND
  One of the major pathophysiologies in advanced chronic obstructive pulmonary disease (COPD) has been attributed to systemic inflammation. Meta-analysis of the 2005 Cochrane Database concluded the effect of nutritional supplementation alone on stable COPD was insufficient to promote body weight gain or exercise capacity. The aim of this study was to investigate the effectiveness of nutritional supplementation therapy using a nutritional supplement containing whey peptide with low-intensity exercise therapy in stable elderly patients with COPD.
  
  
  METHODS
  In stable elderly COPD patients with %IBW and %FEV(1) of less than 110 and 80%, respectively, anti-inflammatory nutritional supplementation therapy was added to low-intensity exercise therapy. Thirty-six COPD patients were divided into those with and those without the ingestion of an anti-inflammatory nutritional supplement containing whey peptide, which exhibited an anti-inflammatory effect. These two groups were designated as the nutritional support and the control groups, respectively. The body composition, skeletal muscle strength, exercise tolerance, health-related QOL (HRQOL), and inflammatory cytokines were evaluated before and three months after nutritional support combined with exercise therapy in both the nutritional support group and the control group.
  
  
  RESULTS
  In the nutritional support group, the body weight, %IBW, FM, energy intake, %AC, Alb, PImax, PEmax, 6MWD, WBI, emotional function, and CRQ total were significantly increased, and the levels of hsCRP, IL-6, IL-8, and TNF-α were reduced significantly, while no significant change was noted in any item of physiological evaluation or any biomarker in the control group.
  
  
  CONCLUSIONS
  Concomitant use of a anti-inflammatory nutritional supplement containing whey peptide, which exhibits an anti-inflammatory effect, with exercise therapy in stable elderly COPD patients with %IBW<110% and %FEV(1)<80% may not only increase body weight but may also inhibit systemic inflammation and thus improve exercise tolerance and HRQOL.
authors.affiliation: Department of Rehabilitation, Akita City General Hospital, Akita, Japan.
authors.forename: Keiyu
authors.initials: K
authors.lastname: Sugawara
authors.forename: Hitomi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kashiwagura
authors.forename: Kohko
authors.initials: K
authors.lastname: Yamada
authors.forename: Satoko
authors.initials: S
authors.lastname: Yanagida
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Homma
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dairiki
authors.forename: Hajime
authors.initials: H
authors.lastname: Sasaki
authors.forename: Atsuyoshi
authors.initials: A
authors.lastname: Kawagoshi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Satake
authors.forename: Takanobu
authors.initials: T
authors.lastname: Shioya
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D019587:Dietary Supplements; D002149:Energy Intake / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008894:Milk Proteins / Q000008:administration & dosage*; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*; D011788:Quality of Life; D016896:Treatment Outcome; D015430:Weight Gain / Q000502:physiology; D000067816:Whey Proteins
chemical_list: D000893:Anti-Inflammatory Agents; D008894:Milk Proteins; D000067816:Whey Proteins