title: Pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects.
abstract: The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h in 12 healthy subjects. The plasma concentrations of (+)-(R)-terazosin at all time points were higher than those of (-)-(S)-terazosin. The area under the plasma concentration-time curve (AUC(0-∞) ) and maximum plasma concentration of (+)-(R)-terazosin were significantly greater than those of the (-)-(S)-terazosin (P < 0.01, respectively). The R/S ratio of AUC(0-∞) of terazosin was 1.68. For the first time, it was proven that the pharmacokinetics of terazosin was stereoselective in healthy Chinese male subjects.
authors.affiliation: Department of Clinical Pharmacology, Aerospace Center Hospital, Beijing, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Man
authors.initials: M
authors.lastname: Yang
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Wang
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Huichen
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D044466:Asian People; D001774:Blood Chemical Analysis / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006262:Health; D006801:Humans; D008297:Male; D011224:Prazosin / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism; D055815:Young Adult
chemical_list: C041226:Terazosin; D011224:Prazosin