title: Postprandial hyperlipidemia in overt and subclinical hypothyroidism.
abstract: OBJECTIVE
  Lipid alterations in overt hypothyroidism (OH) were well known, but its changes in subclinical hypothyroidism (SCH) and postprandial period were not clear. The aim of this study is to evaluate postprandial lipemia by oral lipid tolerance test (OLTT) in patients with OH and SCH.
  
  
  METHODS
  Twenty-five OH and 27 SCH, totally 52 hypothyroid patients [mean age 38.3 ± 12.8 year, body mass index (BMI): 29.0 ± 5.8 kg/m(2)] and 23 BMI- and age-matched healthy controls (mean age 36.7 ± 11.9 years; BMI: 27.1 ± 6.9 kg/m(2)) were included to the study. Anthropometric measurements and HOMA-IR levels were measured. Basal and postprandial lipid profile at 2nd, 4th, 6th and 8th hours were determined by oral lipid tolerance test.
  
  
  RESULTS
  There were not any statistical differences among three groups (control, OH and SCH) in terms of mean fasting levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol, and triglyceride. On the contrary, mean triglyceride levels at postprandial 8th hour in both OH and SCH patients were higher than control subjects (p=0.017 and p=0.049, respectively). Again mean postprandial 8th hour VLDL-cholesterol levels in OH group were also higher than control subjects (p=0.05). In addition mean HOMA-IR value of SCH and OH patients was similar with control subjects (1.5 ± 1.4 in OH; 1.3 ± 0.8 in SCH; 2.2 ± 2.2 in control group).
  
  
  CONCLUSIONS
  Although total, LDL and VLDL-cholesterol, and triglyceride levels were not different from healthy controls, triglyceride and/or VLDL-cholesterol levels apparently increased with OLTT in both OH and SCH patients. Decreased lipid clearance may be responsible for this result.
authors.affiliation: Department of Endocrinology and Metabolism, Dicle University, Faculty of Medicine, Diyarbakir, Turkey. sarikan822@gmail.com
authors.forename: Senay
authors.initials: S
authors.lastname: Arikan
authors.forename: Mithat
authors.initials: M
authors.lastname: Bahceci
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Tuzcu
authors.forename: Fatma
authors.initials: F
authors.lastname: Celik
authors.forename: Deniz
authors.initials: D
authors.lastname: Gokalp
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D015243:Cholesterol, VLDL / Q000097:blood / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D014280:Triglycerides