title: Comparative evaluation of three calcium phosphate synthetic block bone graft materials for bone regeneration in rabbit calvaria.
abstract: Various synthetic materials were developed to be used for implant dentistry and periodontal treatments. Among the various synthetic bone substitutes, calcium phosphate ceramics have been extensively investigated because their mineral chemistry resembles that of human bone. We evaluated the regeneration of three calcium phosphate synthetic block bone grafts in rabbit calvarial noncritical size defects. Four 8-mm-diameter defects were created in each rabbit (N = 10). Three defects, hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP), were randomly filled with one of three fabricated synthetic block bone graft materials. The fourth defect was filled with blood clots. Specimens were harvested at 4 and 8 weeks postsurgery. Histological and histometrical findings indicated that all three calcium phosphate block bone graft materials were able to maintain space significantly better than the control group at both 4 and 8 weeks. In the BCP group, the amount of newly formed bone was increased more than for the other groups. Additionally, β-TCP showed a large resorption of graft materials after 4 weeks postsurgery, while there were only small resorption for HA and BCP.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul120-752, Korea.
authors.forename: Ji-Wan
authors.initials: JW
authors.lastname: Hwang
authors.forename: Jae-Sub
authors.initials: JS
authors.lastname: Park
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
authors.forename: Chang-Sung
authors.initials: CS
authors.lastname: Kim
authors.forename: Kyoo-Sung
authors.initials: KS
authors.lastname: Cho
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Lee
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008422:Materials Testing / Q000379:methods; D011817:Rabbits; D012886:Skull; D012887:Skull Fractures / Q000628:therapy*; D013997:Time Factors
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate; C074950:hydroxyapatite-beta tricalcium phosphate; D017886:Durapatite