title: Antinociceptive effects induced by injection of the galanin receptor 1 agonist M617 into central nucleus of amygdala in rats.
abstract: The present study was performed to explore the antinociceptive effects of M617, a selective galanin receptor 1 agonist, in the central nucleus of amygdala (CeA) of rats. Intra-CeA injection of 0.1 nmol, 0.5 nmol and 1 nmol of M617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, rats received intra-CeA administration of M617 and galanin. The HWL to noxious thermal and mechanical stimulations increased markedly, and there were no significant differences in HWLs of rats received intra-CeA administration of M617 and galanin. The results demonstrated that intra-CeA injection of M617 induced significant antinociceptive effects in CeA of rats, indicating that galanin receptor 1 may be involved in M617-induced antinociception in the CeA of rats.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane, Biotechnology and Neurobiology Laboratory, College of Life Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Shi-Lian
authors.initials: SL
authors.lastname: Xu
authors.forename: Long-Chuan
authors.initials: LC
authors.lastname: Yu
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D019004:Galanin / Q000494:pharmacology* / Q000627:therapeutic use / Q000031:analogs & derivatives; D006358:Hot Temperature; D007267:Injections; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D044091:Receptor, Galanin, Type 1 / Q000819:agonists*; D014110:Touch
chemical_list: D000700:Analgesics; C000614145:M617 peptide; D010446:Peptide Fragments; D044091:Receptor, Galanin, Type 1; D019004:Galanin; D001920:Bradykinin