title: Clinical and histopathological features of a suspected case of fish-eye disease.
abstract: OBJECTIVE
  To report the clinical and histopathological features of a suspected case of fish-eye disease.
  
  
  METHODS
  A 57-year-old man presented with blurred vision. The best corrected visual acuity was 0.8 OD and 1.0 OS. The patient had no family history of cloudy cornea. Slit-lamp examination revealed massive bilateral diffuse corneal clouding. Because of progressive corneal clouding during the previous 3 years, we performed penetrating keratoplasty and cataract surgery. He had a low-plasma, high-density lipoprotein (HDL) concentration. Histopathologically, numerous small vacuoles were dispersed, especially in the anterior corneal stroma. An electron microscope revealed distinct 0.2-3.0-μm lipid vacuoles with a conserved stromal structure.
  
  
  CONCLUSIONS
  We suspected a case of sporadic fish-eye disease in a Japanese patient. Lipid deposition needs to be considered as a cause of diffuse corneal opacity.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan. tatenoh@hirakata.kmu.ac.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tateno
authors.forename: Makoto
authors.initials: M
authors.lastname: Taomoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Jo
authors.forename: Kanji
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Uemura
mesh_terms: D002387:Cataract Extraction; D003318:Corneal Opacity / Q000175:diagnosis* / Q000201:enzymology / Q000601:surgery; D003319:Corneal Stroma / Q000648:ultrastructure*; D006801:Humans; D015948:Keratoplasty, Penetrating; D007863:Lecithin Cholesterol Acyltransferase Deficiency / Q000175:diagnosis* / Q000601:surgery; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D014617:Vacuoles / Q000648:ultrastructure*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D008075:Lipoproteins, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase