title: Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells.
authors.forename: Kumudha
authors.initials: K
authors.lastname: Balakrishnan
authors.forename: Sumesh
authors.initials: S
authors.lastname: Aggarwal
authors.forename: William
authors.initials: W
authors.lastname: Wierda
authors.forename: Varsha
authors.initials: V
authors.lastname: Gandhi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics*; D015870:Gene Expression; D055786:Gene Knockout Techniques; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D051379:Mice; D050998:bcl-2 Homologous Antagonist-Killer Protein / Q000235:genetics*; D051028:bcl-2-Associated X Protein / Q000235:genetics*
chemical_list: C534401:apogossypolone; D050998:bcl-2 Homologous Antagonist-Killer Protein; D051028:bcl-2-Associated X Protein; D006072:Gossypol