title: Uptake of invasive prenatal tests in pregnancies conceived via assisted reproductive technologies: the experience in Queensland, Australia.
abstract: OBJECTIVE
  Prenatal diagnosis of a chromosomal abnormality currently involves the use of an invasive procedure, which has a risk of fetal loss. The aim of this study was to identify whether pregnancies conceived via assisted reproductive technologies were more or less likely to be subjected to an invasive procedure compared with pregnancies that were conceived spontaneously.
  
  
  METHODS
  Population data were collated from three private ultrasound clinics across southeast Queensland, Australia.
  
  
  RESULTS
  Of the 15,032 spontaneously conceived pregnancies, 775 (5.2%) had invasive testing, while 95 (6.0%) of the 1581 pregnancies conceived through assisted reproductive technologies had invasive testing. When the uptake of testing is adjusted by the maternal age the assisted reproductive population was significantly less likely to pursue invasive testing (p = 0.003). Similarly when adjusted for the combined first trimester screen risk estimate, the assisted reproduction population is significantly less likely to undergo invasive testing than the spontaneous population (p = 0.005).
  
  
  CONCLUSIONS
  Pregnancies conceived using assisted reproductive technologies are significantly less likely to be subjected to invasive testing than pregnancies conceived spontaneously in women of the same age and combined first trimester screen risk.
authors.affiliation: Genetic Health Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia. lauren.hunt@health.qld.gov.au
authors.forename: Lauren
authors.initials: L
authors.lastname: Hunt
authors.forename: Madelyn
authors.initials: M
authors.lastname: Peterson
authors.forename: Stephen
authors.initials: S
authors.lastname: Sinnott
authors.forename: Bridget
authors.initials: B
authors.lastname: Sutton
authors.forename: Robert
authors.initials: R
authors.lastname: Cincotta
authors.forename: Gregory
authors.initials: G
authors.lastname: Duncombe
authors.forename: Jackie
authors.initials: J
authors.lastname: Chua
authors.forename: Aideen
authors.initials: A
authors.lastname: McInerney-Leo
mesh_terms: D000293:Adolescent; D000328:Adult; D000649:Amniocentesis / Q000706:statistics & numerical data*; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data*; D002869:Chromosome Aberrations; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D020554:Sperm Injections, Intracytoplasmic; D055815:Young Adult