title: Interaction network of antimicrobial peptides of Arabidopsis thaliana, based on high-throughput yeast two-hybrid screening.
abstract: One mechanism used by plants to respond to infection is the production of antimicrobial peptides (AMPs). In addition to a role in defence, AMPs seem to have other biological functions. Furthermore, the number of cysteine-rich AMP-like peptides appears to have been underpredicted in plant genomes. Such peptides could be involved in plant defence and/or in other biological processes. Here we generated an interaction network between 15 AMPs/AMP-like peptides and ca. 8000 other Arabidopsis thaliana proteins (AtORFeome2.0) and found 53 putative novel interactions. These interactions involve five transcription factors, a subunit of the COP9 signalosome, a heat shock protein, a MAP kinase kinase, a thioredoxin and 4 uncharacterized proteins.
authors.affiliation: Unité de Biologie Animale et Microbienne, Gembloux Agro-Bio Tech, Université de Liège, 6 avenue du Maréchal Juin, 5030 Gembloux, Belgium. Coralie.Damon@ulg.ac.be
authors.forename: Coralie
authors.initials: C
authors.lastname: Damon
authors.forename: Julia
authors.initials: J
authors.lastname: Dmitrieva
authors.forename: Yordan
authors.initials: Y
authors.lastname: Muhovski
authors.forename: Frédéric
authors.initials: F
authors.lastname: Francis
authors.forename: Laurence
authors.initials: L
authors.lastname: Lins
authors.forename: Quentin
authors.initials: Q
authors.lastname: Ledoux
authors.forename: William
authors.initials: W
authors.lastname: Luwaert
authors.forename: István E
authors.initials: IE
authors.lastname: Markó
authors.forename: Sergio
authors.initials: S
authors.lastname: Mauro
authors.forename: Marc
authors.initials: M
authors.lastname: Ongena
authors.forename: Philippe
authors.initials: P
authors.lastname: Thonart
authors.forename: Pascal
authors.initials: P
authors.lastname: Veys
authors.forename: Daniel
authors.initials: D
authors.lastname: Portetelle
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Twizere
authors.forename: Micheline
authors.initials: M
authors.lastname: Vandenbol
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D000075686:COP9 Signalosome Complex; D003545:Cysteine / Q000378:metabolism; D060467:Disease Resistance; D018745:Genome, Plant; D006360:Heat-Shock Proteins / Q000378:metabolism; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D010935:Plant Diseases / Q000382:microbiology*; D057865:Plant Immunity; D021122:Protein Subunits; D013879:Thioredoxins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D020798:Two-Hybrid System Techniques
chemical_list: D000890:Anti-Infective Agents; D029681:Arabidopsis Proteins; D006360:Heat-Shock Proteins; D046912:Multiprotein Complexes; D010455:Peptides; D021122:Protein Subunits; D014157:Transcription Factors; D013879:Thioredoxins; D020929:Mitogen-Activated Protein Kinase Kinases; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D003545:Cysteine