title: The association between some endocrine disruptors and hypospadias in biological samples.
abstract: Hypospadias is a birth defect found in boys in which the urinary tract opening is not at the tip of the penis. The etiology of hypospadias is still unidentified, but endocrine disruptors are considered as one possible cause of hypospadias. In this study, target endocrine disruptor compounds were established for an assay. The target compounds included 5 phthalates (di-(2-ethylhexyl)phthalate (DEHP), di-n-butyl-phthalate (DBP), mono-(2- ethylhexyl) phthalate (MEHP), mono-n-butyl-phthalate (MBP) and phthalic acid (PA)), 2 alkylphenols (n-nonylphenol (n-NP) and t-octylphenol (t-OP)) and bisphenol A. The association between these 8 endocrine disruptors and hypospadias was studied. The levels of endocrine disruptors in the urine and plasma of a control group were compared with those of a patient group. DEHP (P = 0.006) and n-NP (P = 7.26e-6) in the urine samples and PA (P = 0.009) and BPA (P = 7.22e-10) in the plasma samples showed a significant association with hypospadias. The levels of endocrine disruptors in the urine and plasma of the mothers were also compared to those of the patients to investigate the metastasis of the endocrine disruptors from the mother. These levels did not, however, show a relationship with hypospadias (R(2) = 0.001-0.563).
authors.affiliation: Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Haemin
authors.initials: H
authors.lastname: Choi
authors.forename: Joohoon
authors.initials: J
authors.lastname: Kim
authors.forename: Yeongjae
authors.initials: Y
authors.lastname: Im
authors.forename: Sanghouck
authors.initials: S
authors.lastname: Lee
authors.forename: Yunje
authors.initials: Y
authors.lastname: Kim
mesh_terms: D001559:Benzhydryl Compounds; D004051:Diethylhexyl Phthalate / Q000097:blood / Q000652:urine; D052244:Endocrine Disruptors / Q000097:blood* / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007021:Hypospadias / Q000097:blood* / Q000652:urine*; D008297:Male; D010636:Phenols / Q000097:blood / Q000652:urine; D010795:Phthalic Acids / Q000097:blood / Q000652:urine; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004051:Diethylhexyl Phthalate; D052244:Endocrine Disruptors; D010636:Phenols; D010795:Phthalic Acids; C474055:octylphenol; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds