title: The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.
abstract: TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαq protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of Gαi/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling.
authors.affiliation: Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hana
authors.initials: H
authors.lastname: Kim
authors.forename: Jinsung
authors.initials: J
authors.lastname: Kim
authors.forename: Jae-Pyo
authors.initials: JP
authors.lastname: Jeon
authors.forename: Jongyun
authors.initials: J
authors.lastname: Myeong
authors.forename: Jinhong
authors.initials: J
authors.lastname: Wie
authors.forename: Chansik
authors.initials: C
authors.lastname: Hong
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ju-Hong
authors.initials: JH
authors.lastname: Jeon
authors.forename: Insuk
authors.initials: I
authors.lastname: So
mesh_terms: D042783:Endothelial Cells / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D054731:PDZ Domains; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism; D050052:TRPC Cation Channels / Q000737:chemistry / Q000378:metabolism*
chemical_list: D043562:Receptors, G-Protein-Coupled; D011976:Receptors, Muscarinic; D050052:TRPC Cation Channels; C489571:TRPC4 ion channel; C491780:TRPC5 protein, human