title: [Analysis on content of serum monoamine neurotransmitters in macaques with anger-in-induced premenstrual syndrome and liver-qi depression syndrome].
abstract: OBJECTIVE
  To observe the changes in content of monoamine neurotransmitters in the serum of rhesus macaques, and explore the role of serum monoamine neurotransmitters in premenstrual syndrome (PMS) and liver-qi depression induced by anger-in emotion.
  
  
  METHODS
  Social level pressure was applied on 24 female macaques to induce the angry emotional reaction, and then nine of the low-status macaques with anger-in emotional reaction were screened out and were divided into anger-in emotion group, PMS and liver-qi depression group (model group) and Jingqianshu Granule group. Macaques in the last two groups were suffered extruding in a pack cage for inducing PMS liver-qi depression. After 5 d of extruding, experimental animals were evaluated according to the emotional evaluation scale, meanwhile, macaque serum of follicular phase and middle-late luteal phase was collected to analyze the content of serum norepinephrine, dopamine, and 5-hydroxytryptamine.
  
  
  RESULTS
  Compared with the normal control group, the scores of depression of the model group and the anger-in emotion group evaluated with emotional evaluation scale were significantly increased (P<0.01, P<0.05); while the score of the model group was significantly higher than that of the anger-in emotion group (P<0.05), and it returned to normal after Jingqianshu Granule treatment. As compared to the normal control group, serum monoamine neurotransmitter levels of the model group and the anger-in emotion group were increased (P<0.05, P<0.01), and the serum monoamine neurotransmitter levels of the model group were significantly higher than those of the anger-in emotion group (P<0.05), while there was no significant difference when compared with the normal control group after the treatment.
  
  
  CONCLUSIONS
  Anger-in emotion can induce liver-qi depression syndrome which is related to the changes in monoamine neurotransmitters.
authors.affiliation: Key Laboratory of Classics Theory of Traditional Chinese Medicine of the Ministry of Education of China, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China. waysaint@163.com
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Hou
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Chao
authors.forename: Xi-Yang
authors.initials: XY
authors.lastname: Du
authors.forename: Shao-Bo
authors.initials: SB
authors.lastname: Zong
mesh_terms: D000786:Anger; D000818:Animals; D004298:Dopamine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D008253:Macaca mulatta; D018377:Neurotransmitter Agents / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D011293:Premenstrual Syndrome / Q000097:blood* / Q000188:drug therapy / Q000209:etiology*; D012701:Serotonin / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine