title: Clinical factors associated with hepatitis A virus seropositivity in HIV-infected adults living in a country with an epidemiologic shift for hepatitis A virus infection.
abstract: The number of HIV-infected individuals susceptible to Hepatitis A virus (HAV) infection is increasing in Korea; however, it has proven difficult to devise a vaccination policy therefore because limited seroepidemiologic data exists for them. Accordingly, anti-HAV IgG was measured in 188 HIV-infected adults between July 2008 and July 2010. The nadir CD4+ T lymphocyte counts were not different between the HAV-positive and -negative groups (197 ± 138 vs 202 ± 129, P = 0.821). The only factor independently associated with seropositive status was age under 40 yr old (OR 0.017, P < 0.001). Our findings suggest that HAV vaccination in HIV-infected adults should be targeted at persons under the age of 40 yr.
authors.affiliation: Department of Infectious Disease, Inha University Hospital, Incheon, Korea.
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Baek
authors.forename: Chang Oh
authors.initials: CO
authors.lastname: Kim
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Nam Soo
authors.initials: NS
authors.lastname: Koo
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006506:Hepatitis A / Q000150:complications / Q000453:epidemiology*; D035922:Hepatitis A Antibodies / Q000097:blood; D030041:Hepatitis A virus / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D035922:Hepatitis A Antibodies