title: Are cancer trials valid and useful for the general surgeon and surgical oncologist?
abstract: Cancer trials represent a rigorous and clear approach to testing whether an intervention or treatment will alter the outcomes of individuals with cancer in an experimental manner that is beyond the level of observational studies. As such, they remain useful and valid to the day-to-day practice of general surgeons and surgical oncologists. However, the shortcomings of current cancer clinical trials need to be recognized, especially when less than 1% of adults persons with cancer participate in cancer clinical trials, thus leaving the ability to generalize these trials to patients and their surgeons in the real-world setting an open question. Moving forward, physicians, payers, professional societies, advocates, the NCI, and other stakeholders need to develop broader cancer trials to benefit the millions of patients with cancer in the United States.
authors.affiliation: Department of Surgery, Surgical Outcomes Research Center, University of Minnesota and Minneapolis VAMC, MMC# 195, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. alref003@umn.edu
authors.forename: Waddah B
authors.initials: WB
authors.lastname: Al-Refaie
authors.forename: Selwyn M
authors.initials: SM
authors.lastname: Vickers
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards / Q000706:statistics & numerical data; D057186:Comparative Effectiveness Research; D006801:Humans; D008495:Medical Oncology; D009369:Neoplasms / Q000601:surgery*; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D014481:United States