title: [Comparative study of crystallization processes in case of glycine crystallization].
abstract: In our work, the effect of crystallization methods and their parameters on the particle size, particle size-distribution and roundness were investigated in case of glycine crystallization. Three types of crystallization methods were applied according to the solubility results of the substance. In case of cooling crystallization, the effect of cooling and stirring rates were investigated. The feeding and stirring rates were changed in the feeding crystallization. In the antisolvent technique, the effect of cycle and amplitude of the sonification were studied on the particle size. A 3(2) full factorial design was applied for investigation of the effect of crystallization parameters. The results were analyzed by statistical software. The particle size distribution and roundness were measured by laser diffraction and light microscopic image analysis systems. The polymorph type of products was investigated by XRPD. The crystallized product morphology was examined using scanning electron microscopy. We found that the crystallization methods and certain parameters have significant effect on the particle size, particle size distribution. In spite of the modified particle size, morphology, roundness, the polymorph type of the product was the same with the original material.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6.-6720. aigner@pharm.u-szeged.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Aigner
authors.forename: Adám
authors.initials: A
authors.lastname: Szegedi
authors.forename: Viktor
authors.initials: V
authors.lastname: Szabadi
authors.forename: Rita
authors.initials: R
authors.lastname: Ambrus
authors.forename: Tamás
authors.initials: T
authors.lastname: Sovány
authors.forename: Piroska
authors.initials: P
authors.lastname: Szabóné Révész
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003080:Cold Temperature; D003460:Crystallization / Q000379:methods*; D005998:Glycine / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012995:Solubility / Q000187:drug effects; D012997:Solvents / Q000494:pharmacology; D013010:Sonication / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D012997:Solvents; D005998:Glycine