title: Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan.
abstract: BACKGROUND
  The goal of this study was to assess the prevalence and clinical correlates of restless legs syndrome (RLS) among pregnant Taiwanese women.
  
  
  METHODS
  We enrolled 461 pregnant women (18-45 years) admitted at Mackay Memorial Hospital for delivery from September 2010 to May 2011. The face-to-face questionnaire used to gather data included assessment of RLS diagnostic criteria, and questions related to RLS.
  
  
  RESULTS
  The overall prevalence rate of RLS among the study participants was 10.4%; 2.8% were categorized as having chronic RLS. Participants without RLS reported higher folate and iron supplement consumption than those with RLS. Multivariate analysis revealed significant associations of RLS with anemia and peptic ulcer disease. Participants with transient RLS during pregnancy reported more regular coffee consumption before pregnancy, and better sleep latency, duration, and efficiency, than those with chronic RLS. Overall, 81.2% of RLS sufferers reported sleep disturbances.
  
  
  CONCLUSIONS
  Our study revealed highly prevalent but poorly recognized RLS among Taiwanese pregnant women. The identification of predictors such as medical comorbidities, and protectors such as folate and iron supplements, is warranted for obstetric RLS. In most cases, symptoms began during the second or third trimester and resolved within a week after delivery. Restricted coffee consumption before pregnancy is encouraged, but further evidence is needed to support this recommendation.
authors.affiliation: Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Pei-Hao
authors.initials: PH
authors.lastname: Chen
authors.forename: Kuang-Chung
authors.initials: KC
authors.lastname: Liou
authors.forename: Chie-Pein
authors.initials: CP
authors.lastname: Chen
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010437:Peptic Ulcer / Q000150:complications / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D012148:Restless Legs Syndrome / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000209:etiology; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult