title: Facile approach for the dispersion of regenerated cellulose in aqueous system in the form of nanoparticles.
abstract: This study reports a facile method to disperse cellulose in deionized water, wherein a critical condition of regenerated cellulose is discovered, where it completely disperses up to a maximum of 5 g L(-1) concentration in deionized water with the help of ultrasonication. The dispersed cellulose is characterized by TEM and DLS, the latter among which shows 200 nm hydrodynamic radii of cellulose nanoparticles dispersed in deionized water. FTIR analysis of dispersed cellulose reveals that dispersed cellulose losses its crystallinity during regeneration and dispersion step employed in this study. The dispersed cellulose reported in this study is able to form free-standing, transparent films, which were characterized by SEM, XRD, TGA, EDX, and FTIR spectroscopy and show resistance against dissolution in water. Additionally, the dispersed cellulose is able to undergo at least three times faster enzymatic hydrolysis in comparison to pristine microcrystalline cellulose under similar reaction conditions. The dispersed cellulose reported here could be a better material for reinforcement, preparation of hydrogels, and drug delivery applications under physiological environment.
authors.affiliation: School of Applied Science, RMIT University, GPO Box 2476 V, Melbourne, Victoria 3001, Australia.
authors.forename: Mukund
authors.initials: M
authors.lastname: Adsul
authors.forename: Sarvesh K
authors.initials: SK
authors.lastname: Soni
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Bhargava
authors.forename: Vipul
authors.initials: V
authors.lastname: Bansal
mesh_terms: D002482:Cellulose / Q000737:chemistry* / Q000648:ultrastructure; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053838:Scattering, Small Angle; D012972:Sodium Hydroxide / Q000737:chemistry; D013010:Sonication; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D014508:Urea / Q000737:chemistry; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D013535:Suspensions; D014867:Water; D012972:Sodium Hydroxide; D014508:Urea; D002482:Cellulose; C109691:microcrystalline cellulose