title: Assessment of phosphate binding by sevelamer carbonate powder for oral suspension mixed in foods.
abstract: This study investigated mixing sevelamer carbonate powder with foods and beverages other than water. Food samples, including applesauce, oatmeal, chicken, protein powder, scrambled eggs, ginger ale, and diet ginger ale, were subjected to an in vitro assay, and the difference in the amount of phosphate bound between samples pre-exposed to foods and samples where the drug was exposed to foods concurrently was determined Under these assay conditions, pre-exposure to sevelamer carbonate powder had no effect on the ability to bind phosphate. Clinical testing is needed to further evaluate this finding.
authors.affiliation: Analytical Research and Development, Genzyme Corporation, Waltham, MA, USA. martin.hanus@genzyme.com
authors.forename: Martin
authors.initials: M
authors.lastname: Hanus
authors.forename: Eugene
authors.initials: E
authors.lastname: Zhorov
authors.forename: Deborah
authors.initials: D
authors.lastname: Brommage
authors.forename: Melissa
authors.initials: M
authors.lastname: Plone
authors.forename: Stephen Randall
authors.initials: SR
authors.lastname: Holmes-Farley
mesh_terms: D001628:Beverages; D002614:Chelating Agents / Q000008:administration & dosage* / Q000494:pharmacology; D005502:Food; D005504:Food Analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054559:Hyperphosphatemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000150:complications*; D011073:Polyamines / Q000008:administration & dosage* / Q000494:pharmacology; D011208:Powders; D006435:Renal Dialysis / Q000009:adverse effects*; D000069603:Sevelamer; D013535:Suspensions
chemical_list: D002614:Chelating Agents; D011073:Polyamines; D011208:Powders; D013535:Suspensions; D000069603:Sevelamer