title: Tumor oxygen measurements and personalized medicine.
abstract: Tumor hypoxia is probably the most important not yet measurable factor that predicts the outcome of cancer therapy. Hypoxic tumors are resistant to radiation, chemotherapy, and surgery. They signal tumor cells to grow, invade, survive cytotoxic-factor assault, and increase metastatic activity. Therapies aimed at reversing hypoxia-related treatment resistance or normalizing hypoxia are proven effective with level 1 evidence. The weak link remains the lack of satisfactory methods of measurement of tumor oxygenation.
authors.affiliation: Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA. pokunieff@ufl.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Okunieff
authors.affiliation: Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA.
authors.forename: Walter
authors.initials: W
authors.lastname: O'Dell
authors.affiliation: Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA.
authors.forename: Lurong
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, University of Florida, 103633, Gainesville, FL, 32610, USA.
authors.forename: David
authors.initials: D
authors.lastname: Maguire
mesh_terms: D006801:Humans; D000860:Hypoxia / Q000188:drug therapy*; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000628:therapy; D010100:Oxygen / Q000032:analysis*; D057285:Precision Medicine
chemical_list: D010100:Oxygen