title: Nrf2 orchestrates fuel partitioning for cell proliferation.
abstract: Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.
authors.affiliation: Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK. j.d.hayes@dundee.ac.uk
authors.forename: John D
authors.initials: JD
authors.lastname: Hayes
authors.forename: Michael L J
authors.initials: ML
authors.lastname: Ashford