title: Nrf2: a potential target for new therapeutics in liver disease.
abstract: Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.
authors.affiliation: Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Bataille
authors.forename: J E
authors.initials: JE
authors.lastname: Manautou
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000503:physiopathology; D005234:Fatty Liver / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000503:physiopathology; D051267:NF-E2-Related Factor 2 / Q000819:agonists / Q000187:drug effects* / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease
chemical_list: D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human