title: The structures of type I polyketide synthases.
abstract: With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas, USA. adriankc@mail.utexas.edu
authors.forename: Adrian T
authors.initials: AT
authors.lastname: Keatinge-Clay
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D048630:Polyketide Synthases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D001688:Biological Products; D048630:Polyketide Synthases