title: Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.
abstract: Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the left parietal lobe. No changes in Radial Diffusivity (RD; measure of myelin integrity) were observed. Of note, studies in chronic schizophrenia patients report reduced FA, no changes in AD, and increases in RD in WM. Our findings suggest different WM microstructural pathology in 22q11.2DS than in patients with schizophrenia.
authors.affiliation: Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. zora@bwh.harvard.edu
authors.forename: Z
authors.initials: Z
authors.lastname: Kikinis
authors.forename: T
authors.initials: T
authors.lastname: Asami
authors.forename: S
authors.initials: S
authors.lastname: Bouix
authors.forename: C T
authors.initials: CT
authors.lastname: Finn
authors.forename: T
authors.initials: T
authors.lastname: Ballinger
authors.forename: E
authors.initials: E
authors.lastname: Tworog-Dube
authors.forename: R
authors.initials: R
authors.lastname: Kucherlapati
authors.forename: R
authors.initials: R
authors.lastname: Kikinis
authors.forename: M E
authors.initials: ME
authors.lastname: Shenton
authors.forename: M
authors.initials: M
authors.lastname: Kubicki
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D004062:DiGeorge Syndrome / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D055815:Young Adult