title: Chediak-Higashi syndrome presenting in accelerated phase.
abstract: Chediak-Higashi Syndrome (CHS) is a rare autosomal recessive disorder, characterized by silver hair, recurrent infections, partial oculo-cutaneous albinism, mild coagulation defect and progressive neuropathy. The characteristic feature of CHS is the presence of huge lysosomes and cytoplasmic inclusions within different body cells like the white blood cells. The disease has an early onset but usually presents in an accelerated phase. We present a case of a 2 years old boy with high grade fever, bilateral cervical lymphadenopathy, hepatosplenomegaly, abdominal distention of 28 days duration. He was diagnosed with Chediak-Higashi syndrome in accelerated phase on the basis of clinical presentation, morphological findings on peripheral blood film and bone marrow aspirate.
authors.affiliation: Department of Haematology, Fauji Foundation Hospital, Jehlum Road, Rawalpindi. dr_tanzeel@yahoo.co.uk
authors.forename: Tanzeel
authors.initials: T
authors.lastname: Imran
authors.forename: Lubna
authors.initials: L
authors.lastname: Zafar
authors.forename: Madeeha
authors.initials: M
authors.lastname: Rehan
authors.forename: Aqsa
authors.initials: A
authors.lastname: Nasir
authors.forename: Parveen Akhtar
authors.initials: PA
authors.lastname: Tariq
authors.forename: Iffat
authors.initials: I
authors.lastname: Batool
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001773:Blood Cells / Q000166:cytology; D016913:Blood Component Transfusion; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D002609:Chediak-Higashi Syndrome / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002675:Child, Preschool; D017809:Fatal Outcome; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D011379:Prognosis
chemical_list: D000900:Anti-Bacterial Agents