title: Invasive lobular carcinoma of the breast: cytometric and immunohistochemical characteristics of 96 cases.
abstract: The aim of the study was to present microscopic, cytometric and immunohistochemical characteristics of a group of 96 invasive lobular carcinomas (ILC) of the breast. Ninety six patients treated surgically at the Department of Surgical Oncology, Centre of Oncology - Maria Skłodowska-Curie Memorial Institute, Cracow Branch, between 1983 and 1996, were included into the study. In 56 (58.3%) cases, a classical pattern of ILC was diagnosed, whereas atypical variants (solid, pleomorphic, pleomorphic with signet ring cells, signet ring cell, and tubulolobular) were recognized in 40 (41.7%) cases. ILC was characterized by lack of E-cadherin expression, high rate of steroid receptor expression, low rate of P53 and c-erb-B2 expressing tumours, low MIB-1 labelling index, and low S phase fraction, as well as high rate of diploid lesions.
authors.affiliation: Department of Tumour Pathology, Maria Skłodowska-Curie Memorial Institute, Krakow, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Skotnicki
authors.forename: Janusz
authors.initials: J
authors.lastname: Ryś
authors.forename: Paweł
authors.initials: P
authors.lastname: Blecharz
authors.forename: Marian
authors.initials: M
authors.lastname: Reinfuss
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jakubowicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Ambicka
authors.forename: Anna
authors.initials: A
authors.lastname: Kruczak
authors.forename: Bożena
authors.initials: B
authors.lastname: Lackowska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor