title: In vivo antioxidant activity of total flavonoids from indocalamus leaves in aging mice caused by D-galactose.
abstract: OBJECTIVE
  The aim of this thesis is to explore antioxidant activity of total flavonoids extracted from indocalamus leaves.
  
  
  METHODS
  Aging mice model was established by D-galactose induction. Three groups of mice were treated with total flavonoids extracted from indocalamus leaves at doses of 20, 40 and 80 mg/kg d bw respectively. The antioxidant status in the aging mice was measured by determining the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and total anti-oxidant capability (T-AOC) in the serum and liver and malondialdehyde (MDA) content in the serum, liver and brain.
  
  
  RESULTS
  Compared with control group, extracts of indocalamus leaves significantly enhanced activities of SOD, GSH-Px, CAT in the serum and liver, and decreased MDA content in the serum, liver and brain at the tested doses.
  
  
  CONCLUSIONS
  Total flavonoids extracted from indocalamus leaves demonstrated the potent antioxidant activity.
authors.affiliation: School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin Province, PR China. jinshenglang@163.com
authors.forename: Sheng-lang
authors.initials: SL
authors.lastname: Jin
authors.forename: Yong-guang
authors.initials: YG
authors.lastname: Yin
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005690:Galactose / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D006109:Poaceae / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005690:Galactose