title: Evaluation of the osteoconductive potential of bone substitutes embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells.
abstract: OBJECTIVE
  Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical use.
  
  
  METHODS
  Materials tested were Bio-Oss, Bi-Ostetic, OraGraft, and ProOsteon. These Simple and composite bone substitutes were embedded with osteoprogenitor cells derived from either the human maxillary sinus schneiderian membrane (hMSSM) or from maxillary tuberosity bone marrow and then monitored both in vitro and in vivo.
  
  
  RESULTS
  Cell adherence and proliferation was most pronounced in OraGraft, followed by ProOsteon. In vivo bone formation, within the bone graft, was also observed, with most marked results in OraGraft and ProOsteon grafts.
  
  
  CONCLUSIONS
  The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Technion-I.I.T, Haifa, Israel; Department of Oral & Maxillofacial Surgery, Carmel Medical Center, Haifa, Israel.
authors.forename: Samer
authors.initials: S
authors.lastname: Srouji
authors.forename: Dror
authors.initials: D
authors.lastname: Ben-David
authors.forename: Alessia
authors.initials: A
authors.lastname: Funari
authors.forename: Mara
authors.initials: M
authors.lastname: Riminucci
authors.forename: Paolo
authors.initials: P
authors.lastname: Bianco
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D018786:Bone Substitutes / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D006882:Hydroxyapatites / Q000494:pharmacology*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000494:pharmacology; D009297:Nasal Mucosa / Q000601:surgery*; D010012:Osteogenesis / Q000187:drug effects*; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: C000591211:Bi-Ostetic; C077540:Bio-Oss; D018786:Bone Substitutes; D006882:Hydroxyapatites; D008903:Minerals; C000591212:OraGraft; C000591213:ProOsteon