title: Metal-free, NHPI catalyzed oxidative cleavage of C-C double bond using molecular oxygen as oxidant.
abstract: A metal-free N-hydroxyphthalimide (NHPI) catalyzed aerobic oxidative cleavage of olefins has been developed. Molecular oxygen is used as the oxidant and reagent for this oxygenation reaction. This methodology has prevented the use of toxic metals or overstoichiometric amounts of traditional oxidants, showing good economical and environmental advantages. Based on the experimental observations, a plausible mechanism is proposed.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Riyuan
authors.initials: R
authors.lastname: Lin
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010797:Phthalimides / Q000737:chemistry*
chemical_list: D000475:Alkenes; D016877:Oxidants; D010797:Phthalimides; C037437:N-hydroxyphthalimide; D010100:Oxygen