title: MicroRNAs tune cerebral cortical neurogenesis.
abstract: MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding genes harbor miRNA recognition sequences in their 3' untranslated region and are thus putative targets. While functions of miRNAs have been extensively characterized in various tissues, their multiple contributions to cerebral cortical development are just beginning to be unveiled. This review aims to outline the evidence collected to date demonstrating a role for miRNAs in cerebral corticogenesis with a particular emphasis on pathways that control the birth and maturation of functional excitatory projection neurons.
authors.affiliation: GIGA-Neurosciences, University of Liège, CHU Sart Tilman, Belgium.
authors.forename: M-L
authors.initials: ML
authors.lastname: Volvert
authors.forename: F
authors.initials: F
authors.lastname: Rogister
authors.forename: G
authors.initials: G
authors.lastname: Moonen
authors.forename: B
authors.initials: B
authors.lastname: Malgrange
authors.forename: L
authors.initials: L
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D023421:Models, Animal; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D043244:Ribonuclease III / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D043244:Ribonuclease III