title: Anti-GQ1b-negative Miller Fisher syndrome after Campylobacter jejuni enteritis.
abstract: Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipo-oligosaccharides of certain bacteria, e.g., Campylobacter jejuni. Anti-GQ1b antibody is a powerful diagnostic marker for Miller Fisher syndrome. However, only a small number of anti-GQ1b-negative Miller Fisher syndrome cases are documented. A 13-year-old boy demonstrated typical clinical features of Miller Fisher syndrome 1 week after C. jejuni enteritis, but was anti-GQ1b and anti-GM1b antibody-negative.
authors.affiliation: Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea. pdsnoopy@yahoo.co.kr.
authors.forename: Kyung Yeon
authors.initials: KY
authors.lastname: Lee
mesh_terms: D001259:Ataxia / Q000209:etiology; D001763:Blepharoptosis / Q000209:etiology; D002169:Campylobacter Infections / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D016123:Campylobacter jejuni; D002648:Child; D004172:Diplopia / Q000209:etiology; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000209:etiology* / Q000503:physiopathology; D009460:Neurologic Examination; D012018:Reflex
chemical_list: D005732:Gangliosides; D005677:G(M1) Ganglioside; C029624:ganglioside M1b; C039129:GQ1b ganglioside