title: Nonionic block copolymers assemble on the surface of protein bionanoparticle.
abstract: Efficient delivery of therapeutic proteins to a target site remains a challenge due to rapid clearance from the body. Here, we selected tobacco mosaic virus (TMV) as a model protein system to investigate the interactions between the protein and a nonionic block copolymer as a possible protecting agent for the protein. By varying the temperature, we were able to obtain core-shell structures based on hydrophobic interactions among PO blocks and noncovalent interactions between TMV and EO blocks. The protein-polymer interactions were characterized by dynamic light scattering and isothermal titration calorimetry. This study establishes principles for the possible design of clinically useful protein delivery systems.
authors.affiliation: National Research Centre of Engineering Plastics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.forename: Jingxia
authors.initials: J
authors.lastname: Gu
authors.forename: Man
authors.initials: M
authors.lastname: Wu
authors.forename: Shidong
authors.initials: S
authors.lastname: Jiang
authors.forename: Dayong
authors.initials: D
authors.lastname: Wu
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Niu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000327:Adsorption; D008823:Micelles; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011487:Protein Conformation; D013499:Surface Properties; D014027:Tobacco Mosaic Virus / Q000737:chemistry*; D014764:Viral Proteins / Q000737:chemistry*
chemical_list: D008823:Micelles; D014764:Viral Proteins; D020442:Poloxamer