title: Beta-blocker use is not associated with slow flow during rotational atherectomy.
abstract: OBJECTIVE
  The purpose of this study was to investigate the association between beta-blocker use and slow flow during rotational atherectomy (RA).
  
  
  BACKGROUND
  RA is often performed as part of percutaneous coronary interventions for the treatment of calcified lesions; however, the procedure can be complicated by slow flow. Previous reports suggested that the use of beta-blockers was associated with slow flow during RA.
  
  
  METHODS
  A total of 186 patients who received RA were included, and 87 patients were on beta-blockers. The occurrence of slow flow was compared between the beta-blocker group (n = 87) and the non-beta-blocker group (n = 99). Multivariate logistic regression analysis was performed to investigate whether the use of beta-blockers was associated with slow flow.
  
  
  RESULTS
  The occurrence of slow flow was not different between the beta-blocker group (29.9%) and the non-beta-blocker group (24.2%; P=.39). The use of beta-blockers was not significantly associated with slow flow (odds ratio, 0.75; 95% confidence interval, 0.34-1.68; P=.49) after controlling for all potential confounding factors.
  
  
  CONCLUSIONS
  There was no definitive association between slow flow and the use of beta-blockers during RA. There is no need to discontinue beta-blockers in patients receiving RA.
authors.affiliation: Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, Amanuma 1-847, Omiya, Saitama, 330-8503 Japan. ZXH03005@nifty.ne.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Ryo
authors.initials: R
authors.lastname: Naito
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Arao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funayama
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kubo
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D017225:Atherectomy, Coronary / Q000009:adverse effects* / Q000379:methods; D002114:Calcinosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D015986:Confounding Factors, Epidemiologic; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000175:diagnosis / Q000453:epidemiology; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists