title: Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery.
abstract: BACKGROUND
  The safety and durability of endoscopic vein graft harvest in coronary artery bypass graft (CABG) surgery has recently been called into question.
  
  
  OBJECTIVE
  To compare the long-term outcomes of endoscopic vs open vein-graft harvesting for Medicare patients undergoing CABG surgery in the United States.
  
  
  METHODS
  An observational study of 235,394 Medicare patients undergoing isolated CABG surgery between 2003 and 2008 at 934 surgical centers participating in the Society of Thoracic Surgeons (STS) national database. The STS records were linked to Medicare files to allow longitudinal assessment (median 3-year follow-up) through December 31, 2008.
  
  
  METHODS
  All-cause mortality. Secondary outcome measures included wound complications and the composite of death, myocardial infarction, and revascularization.
  
  
  RESULTS
  Based on Medicare Part B coding, 52% of patients received endoscopic vein-graft harvesting during CABG surgery. After propensity score adjustment for clinical characteristics, there were no significant differences between long-term mortality rates (13.2% [12,429 events] vs 13.4% [13,096 events]) and the composite of death, myocardial infarction, and revascularization (19.5% [18,419 events] vs 19.7% [19,232 events]). Time-to-event analysis for those patients receiving endoscopic vs open vein-graft harvesting revealed adjusted hazard ratios [HRs] of 1.00 (95% CI, 0.97-1.04) for mortality and 1.00 (95% CI, 0.98-1.05) for the composite outcome. Endoscopic vein-graft harvesting was associated with lower harvest site wound complications relative to open vein-graft harvesting (3.0% [3654/122,899 events] vs 3.6% [4047/112,495 events]; adjusted HR, 0.83; 95% CI, 0.77-0.89; P < .001).
  
  
  CONCLUSIONS
  Among patients undergoing CABG surgery, the use of endoscopic vein-graft harvesting compared with open vein-graft harvesting was not associated with increased mortality.
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Judson B
authors.initials: JB
authors.lastname: Williams
authors.forename: Eric D
authors.initials: ED
authors.lastname: Peterson
authors.forename: J Matthew
authors.initials: JM
authors.lastname: Brennan
authors.forename: Art
authors.initials: A
authors.lastname: Sedrakyan
authors.forename: Dale
authors.initials: D
authors.lastname: Tavris
authors.forename: John H
authors.initials: JH
authors.lastname: Alexander
authors.forename: Renato D
authors.initials: RD
authors.lastname: Lopes
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Dokholyan
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Sean M
authors.initials: SM
authors.lastname: O'Brien
authors.forename: Robert E
authors.initials: RE
authors.lastname: Michler
authors.forename: Vinod H
authors.initials: VH
authors.lastname: Thourani
authors.forename: Fred H
authors.initials: FH
authors.lastname: Edwards
authors.forename: Hesha
authors.initials: H
authors.lastname: Duggirala
authors.forename: Thomas
authors.initials: T
authors.lastname: Gross
authors.forename: Danica
authors.initials: D
authors.lastname: Marinac-Dabic
authors.forename: Peter K
authors.initials: PK
authors.lastname: Smith
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000401:mortality* / Q000601:surgery*; D016208:Databases, Factual; D004724:Endoscopy / Q000401:mortality; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D006278:Medicare / Q000706:statistics & numerical data; D009203:Myocardial Infarction / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000453:epidemiology; D020858:Tissue and Organ Harvesting / Q000379:methods*; D016896:Treatment Outcome; D014481:United States; D014680:Veins / Q000637:transplantation