title: Bioassay-guided isolation of prenylated xanthones and polycyclic acylphloroglucinols from the leaves of Garcinia nujiangensis.
abstract: Bioassay-guided fractionation of the acetone extract of the leaves of Garcinia nujiangensis resulted in the isolation of two new prenylated xanthones, nujiangexanthones A (1) and B (2), three new polycyclic polyprenylated acylphloroglucinols, nujiangefolins A-C (3-5), and 10 known related analogues. The structures of compounds 1-5 were elucidated by interpretation of their spectroscopic data. Compounds 3 and 4 are unusual polycyclic polyprenylated acylphloroglucinols in which the enol hydroxy group forms a six-membered ring with a benzene ring carbon. The compounds isolated were evaluated for their cytotoxic effects against 11 cancer cell lines and immortalized MIHA normal liver cells, and the test substances demonstrated selectivity toward the cancer cells. Isojacareubin (6) was found to be the most potent cytotoxic compound of those tested.
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People's Republic of China.
authors.forename: Zheng-Xiang
authors.initials: ZX
authors.lastname: Xia
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.forename: Yuan-Zhi
authors.initials: YZ
authors.lastname: Lao
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Tan
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D054876:Prenylation; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014966:Xanthenes; D044004:Xanthones; C458659:isojacareubin; D010696:Phloroglucinol