title: Prions in yeast.
abstract: The concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the "protein only" model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-β aggregates (amyloids). Recently, there has been an explosion in the number of recognized prions in yeast. Yeast continues to lead the way in understanding cellular control of prion propagation, prion structure, mechanisms of de novo prion formation, specificity of prion transmission, and the biological roles of prions. This review summarizes what has been learned from yeast prions.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA. suel@uic.edu
authors.forename: Susan W
authors.initials: SW
authors.lastname: Liebman
authors.forename: Yury O
authors.initials: YO
authors.lastname: Chernoff
mesh_terms: D011328:Prions / Q000502:physiology*; D015003:Yeasts / Q000378:metabolism*
chemical_list: D011328:Prions