title: In vitro and in vivo activities of the novel Ketolide RBx 14255 against Clostridium difficile.
abstract: The MIC(90) of RBx 14255, a novel ketolide, against Clostridium difficile was 4 μg/ml (MIC range, 0.125 to 8 μg/ml), and this drug was found to be more potent than comparator drugs. An in vitro time-kill kinetics study of RBx 14255 showed time-dependent bacterial killing for C. difficile. Furthermore, in the hamster model of C. difficile infection, RBx 14255 demonstrated greater efficacy than metronidazole and vancomycin, making it a promising candidate for C. difficile treatment.
authors.affiliation: Department of Infectious Diseases, New Drug Discovery Research, Ranbaxy Research Laboratories, Gurgaon, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.forename: Tarun
authors.initials: T
authors.lastname: Mathur
authors.forename: Tarani K
authors.initials: TK
authors.lastname: Barman
authors.forename: G
authors.initials: G
authors.lastname: Ramkumar
authors.forename: Ashish
authors.initials: A
authors.lastname: Bhati
authors.forename: Gunjan
authors.initials: G
authors.lastname: Shukla
authors.forename: Vandana
authors.initials: V
authors.lastname: Kalia
authors.forename: Manisha
authors.initials: M
authors.lastname: Pandya
authors.forename: V Samuel
authors.initials: VS
authors.lastname: Raj
authors.forename: Dilip J
authors.initials: DJ
authors.lastname: Upadhyay
authors.forename: Chetana
authors.initials: C
authors.lastname: Vaishnavi
authors.forename: Anjan
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: Biswajit
authors.initials: B
authors.lastname: Das
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Bhatnagar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects* / Q000254:growth & development; D006224:Cricetinae; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D006801:Humans; D048628:Ketolides / Q000138:chemical synthesis / Q000494:pharmacology*; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015996:Survival Rate; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; C580587:Rbx 14255; D008795:Metronidazole; D014640:Vancomycin