title: Pd-catalyzed benzylic C-H amidation with benzyl alcohols in water: a strategy to construct quinazolinones.
abstract: A novel method for the synthesis of 4-phenylquinazolinones via a palladium-catalyzed domino reaction of o-aminobenzamides with benzyl alcohols is developed. This protocol involves N-benzylation, benzylic C-H amidation, and dehydrogenation in water, which may play an important role in the smooth generation of the (η(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. hidemasa.hikawa@phar.toho-u.ac.jp
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Hikawa
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ino
authors.forename: Hideharu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Yokoyama
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014867:Water
chemical_list: D001549:Benzamides; D001592:Benzyl Alcohols; D052999:Quinazolinones; D014867:Water; D010165:Palladium; D002244:Carbon; D006859:Hydrogen