title: What's new in regenerative medicine: split up of the mesenchymal stem cell family promises new hope for cardiovascular repair.
abstract: Coronary artery disease (CAD) is exceedingly prevalent and requires care optimization. Regenerative medicine holds promise to improve the clinical outcome of CAD patients. Current approach consists in subsidizing the infarcted heart with boluses of autologous stem cells from the bone marrow. Moreover, mesenchymal stem cells (MSCs) are in the focus of intense research owing to an apparent superiority in plasticity and regenerative capacity compared with hematopoietic stem cells. In this review, we report recent findings indicating the presence, within the heterogeneous MSC population, of perivascular stem cells expressing typical pericyte markers. Moreover, we focus on recent research showing the presence of similar cells in the adventitia of large vessels. These discoveries were fundamental to shape a roadmap toward clinical application in patients with myocardial ischemia. Adventitial stem cells are ideal candidates for promotion of cardiac repair owing to their ease of accessibility and expandability and potent vasculogenic activity.
authors.affiliation: Multimedica IRCCS, Milan, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Vono
authors.forename: Gaia
authors.initials: G
authors.lastname: Spinetti
authors.forename: Miriam
authors.initials: M
authors.lastname: Gubernator
authors.forename: Paolo
authors.initials: P
authors.lastname: Madeddu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003324:Coronary Artery Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000639:trends*; D059630:Mesenchymal Stem Cells / Q000145:classification* / Q000378:metabolism; D009203:Myocardial Infarction / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D020286:Pericytes / Q000145:classification* / Q000378:metabolism; D010641:Phenotype; D012038:Regeneration / Q000235:genetics; D044968:Regenerative Medicine / Q000639:trends*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers