title: Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety.
abstract: A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug.
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574 199, Karnataka, India.
authors.forename: Adithya
authors.initials: A
authors.lastname: Adhikari
authors.forename: Balakrishna
authors.initials: B
authors.lastname: Kalluraya
authors.forename: Kizhakke Veedu
authors.initials: KV
authors.lastname: Sujith
authors.forename: Kuluvar
authors.initials: K
authors.lastname: Gouthamchandra
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Jairam
authors.forename: Riaz
authors.initials: R
authors.lastname: Mahmood
authors.forename: Ravish
authors.initials: R
authors.lastname: Sankolli
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D011720:Pyrazoles; D011743:Pyrimidines; C030986:pyrimidine