title: Biodistribution and metabolism of 11C-labeled Kendine 91 in mice and rats.
abstract: The biodistribution pattern of [(11)C]Kendine 91 (a novel HDAC inhibitor) after IV administration has been evaluated using Positron Emission Tomography (rats) and gamma counting of dissected tissues (rats and mice) at different doses (1 μg/kg and 10.0 mg/kg). Metabolism in mice plasma has been also investigated by radio-HPLC. Obtained results (fast accumulation in lungs, heart, kidneys and liver; lower uptake in pancreas and muscle) are in concordance with previously reported results using HPLC/MS-MS. Plasma analysis studies showed a fast metabolism of the radiotracer.
authors.affiliation: Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gómez-Vallejo
authors.forename: Abraham
authors.initials: A
authors.lastname: Martín
authors.forename: Maialen
authors.initials: M
authors.lastname: Aginagalde
authors.forename: Eneko
authors.initials: E
authors.lastname: San Sebastian
authors.forename: Daniel
authors.initials: D
authors.lastname: Padro
authors.forename: Fernando P
authors.initials: FP
authors.lastname: Cossío
authors.forename: Jordi
authors.initials: J
authors.lastname: Llop
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006877:Hydroxamic Acids / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D049268:Positron-Emission Tomography; D011758:Pyrroles / Q000097:blood / Q000493:pharmacokinetics*; D011874:Radiometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D002250:Carbon Radioisotopes; D006877:Hydroxamic Acids; D011758:Pyrroles; C540813:kendine 91