title: Association between ischemia-modified albumin, homocysteine, vitamin B(12) and folic acid in patients with severe sepsis.
abstract: BACKGROUND
  The aim of the present study was to investigate serum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B(12) and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects.
  
  
  METHODS
  This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18-65 years and 70 (34 male, 36 female) healthy control subjects aged 18-65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis.
  
  
  RESULTS
  Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.01 for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B(12) and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis.
  
  
  CONCLUSIONS
  Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.
authors.affiliation: Department of Biochemistry, University of Selcuk, Meram Faculty of Medicine, Konya, Turkey.
authors.forename: Said Sami
authors.initials: SS
authors.lastname: Erdem
authors.forename: Fatma Hümeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Hümeyra
authors.initials: H
authors.lastname: Çiçekler
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gül
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000097:blood*; D016905:Gram-Negative Bacterial Infections / Q000097:blood; D016908:Gram-Positive Bacterial Infections / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014805:Vitamin B 12 / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D006710:Homocysteine; D002097:C-Reactive Protein; D005492:Folic Acid; D014805:Vitamin B 12; D000075462:Serum Albumin, Human