title: Pharmacokinetics and bioequivalence in the pig of two ivermectin feed formulations.
abstract: Two premix products containing the endectocide ivermectin were compared for pharmacokinetic profiles and bioequivalence in young pigs. Test and reference articles were administered to individual pigs in-feed at 12-h intervals for a total of 14 doses. Plasma concentration-time profiles were compared after provision of the final doses of medicated feed, by which time steady-state concentrations of ivermectin had been achieved. The pharmacokinetic variables monitored were peak concentration (Cmax ), area under the curve (AUC)0-last , elimination half-life of the terminal phase (T1/2 λz) and average steady-state concentration (Css ), determined by noncompartmental analysis. Logarithmic transformation of the variables was carried out when appropriate. Analysis of data by the Classic Method yielded confidence intervals of 80.59-114.47 (for AUC0-last ), 90.38-119.68 (for Cmax ) and 84.70-111.96 (for Css ). It was concluded that the two articles were bioequivalent for ivermectin.
authors.affiliation: Royal Veterinary College, Hatfield, Herts, UK. plees@rvc.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Lees
authors.forename: Z
authors.initials: Z
authors.lastname: Cheng
authors.forename: M
authors.initials: M
authors.lastname: Chambers
authors.forename: G
authors.initials: G
authors.lastname: Speirs
authors.forename: D
authors.initials: D
authors.lastname: Hennessy
authors.forename: E M
authors.initials: EM
authors.lastname: Abbott
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D006207:Half-Life; D007559:Ivermectin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D015203:Reproducibility of Results; D013552:Swine / Q000378:metabolism*; D013810:Therapeutic Equivalency
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin