title: Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS).
  
  
  METHODS
  Hippocampal specimens from 54 patients with MTLE (27 patients with right MTLE and 27 with left MTLE) and unilateral MTS, who were separated into GCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.
  
  
  RESULTS
  GCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. The presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.
  
  
  CONCLUSIONS
  GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined.
authors.affiliation: Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo SP, Brazil. rafaelscarpa@uol.com.br
authors.forename: Rafael Scarpa da Costa
authors.initials: RS
authors.lastname: Neves
authors.forename: Ivanda
authors.initials: I
authors.lastname: de Souza Silva Tudesco
authors.forename: Anaclara Prada
authors.initials: AP
authors.lastname: Jardim
authors.forename: Luís Otávio Sales Ferreira
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Carmen
authors.initials: C
authors.lastname: Lancellotti
authors.forename: Taíssa
authors.initials: T
authors.lastname: Ferrari-Marinho
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Hamad
authors.forename: Murilo
authors.initials: M
authors.lastname: Marinho
authors.forename: Ricardo Silva
authors.initials: RS
authors.lastname: Centeno
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Carla Alessandra
authors.initials: CA
authors.lastname: Scorza
authors.forename: Elza Márcia Targas
authors.initials: EM
authors.lastname: Yacubian
mesh_terms: D000328:Adult; D000368:Aged; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000473:pathology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology* / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies