title: Selective reduction of ketones using water as a hydrogen source under high hydrostatic pressure.
abstract: A selective reduction of a broad variety of ketones is described. The method is based on the combination of a Ni-Al alloy and high hydrostatic pressure (HHP, 2.8 kbar) in an aqueous medium. The reaction of the Ni-Al alloy with water provides in situ hydrogen generation and the high pressure ensures that the H(2) formed remains in the solution, thus the C=O reduction readily occurs. The application of the HHP resulted in selective formation of the desired products and the common problem of non-selective overhydrogenation could be avoided. In most cases the reductions resulted in high yields and excellent selectivities without the use of any base.
authors.affiliation: University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Tomin
authors.forename: Alexander
authors.initials: A
authors.lastname: Lazarev
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Bere
authors.forename: Hana
authors.initials: H
authors.lastname: Redjeb
authors.forename: Béla
authors.initials: B
authors.lastname: Török
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D000535:Aluminum / Q000737:chemistry; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D006874:Hydrostatic Pressure; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D010084:Oxidation-Reduction; D014867:Water / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001555:Benzene Derivatives; D007659:Ketones; D014867:Water; D009532:Nickel; D006859:Hydrogen; D000535:Aluminum