title: Effect of combined topical heparin and steroid on corneal neovascularization in children.
abstract: OBJECTIVE
  To demonstrate the effect of topical heparin combined with topical steroid on corneal neovascularization (CN) in children.
  
  
  METHODS
  Four children (5 eyes) with new-onset progressive CN in at least one eye received topical rimexolone or dexamethasone in combination with heparin until complete regression of CN was obtained. The regression of CN was documented by slit-lamp or anterior segment photography.
  
  
  RESULTS
  All 5 eyes showed complete regression of CN within 5 months. An anti-angiogenic effect was found as early as 1 week after starting topical combination treatment. No ocular and systemic side effects were detected and treatment was well tolerated by all children. In the 3 eyes with involvement of the optical axis, symmetrical visual acuity was obtained by amblyopia treatment. Recurrence of the CN was detectable in 2 eyes at 1 and 6 months, respectively, after ending combination therapy. Both eyes responded favorably to re-treatment.
  
  
  CONCLUSIONS
  Combination of topical heparin and steroid leads to rapid regression and complete inactivity of CN. This therapeutic approach is promising, especially in children with limited therapeutic alternatives and a high risk for amblyopia.
authors.affiliation: Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Rike
authors.initials: R
authors.lastname: Michels
authors.forename: Stephan
authors.initials: S
authors.lastname: Michels
authors.forename: Stephan
authors.initials: S
authors.lastname: Kaminski
mesh_terms: D000287:Administration, Topical; D000925:Anticoagulants / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D016510:Corneal Neovascularization / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D011245:Pregnadienes; D003907:Dexamethasone; D006493:Heparin; C013769:rimexolone