title: [The effects of pH0 on electrophysiological properties of VSMCs in brain artery of spontaneously hypertensive rats].
abstract: OBJECTIVE
  To investigate the effects of pH0 on the electrophysiological properties of vascular smooth muscle cells (VSMCs) in brain artery of spontaneously hypertension rats (SHR).
  
  
  METHODS
  We studied the effects and the ion mechanism of pH0 on whole-cell membrane current of VSMCs in brain artery of 200 - 250 g SHR by whole-cell patch clamp recordings.
  
  
  RESULTS
  1. Acidic pH0 could inhibit the outward current of VSMCs of brain artery in SHR in a voltage-dependent manner. It induced a more pronounced inhibition of the outward current from 0 to + 60mV; 2. In the presence of 1 mmol/L TEA, the inhibition of acidic pH0 on the outward current of VSMCs of brain artery was inhibited.
  
  
  CONCLUSIONS
  The changes of outward current of VSMCs of brain artery in SHR induced by pH0 may be connected with BKCa channel.
authors.affiliation: Medical College of Shihezi University, Key Laboratory of Xinjiang Endemic and Ethnic Diseases-Department of Electrophysiology, Shihezi, China.
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Shang
authors.forename: Jun-qiang
authors.initials: JQ
authors.lastname: Si
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Lian
authors.forename: Ke-tao
authors.initials: KT
authors.lastname: Ma
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000166:cytology; D055724:Electrophysiological Phenomena; D045604:Extracellular Fluid / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR