title: Stability and stabilization for models of chemostats with multiple limiting substrates.
abstract: We study chemostat models in which multiple species compete for two or more limiting nutrients. First, we consider the case where the nutrient flow and species removal rates and input nutrient concentrations are all given as positive constants. In that case, we use Brouwer degree theory to give conditions guaranteeing that the models admit globally asymptotically stable componentwise positive equilibrium points, from all componentwise positive initial states. Then we use the results to develop stabilization theory for a class of controlled chemostats with two or more limiting nutrients. For cases where the dilution rate and input nutrient concentrations can be selected as controls, we prove that many different componentwise positive equilibria can be made globally asymptotically stable. This extends the existing control results for chemostats with one limiting nutrient. We demonstrate our methods in simulations.
authors.affiliation: EPI INRIA DISCO, L2S-CNRS-Supélec, 3 rue Joliot Curie, 91192, Gif-sur-Yvette, France. frederic.mazenc@lss.supelec.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mazenc
authors.forename: Michael
authors.initials: M
authors.lastname: Malisoff
mesh_terms: D019149:Bioreactors; D003198:Computer Simulation; D008954:Models, Biological; D013045:Species Specificity