title: Genome sequence of herpes simplex virus 1 strain McKrae.
abstract: The herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent compared to other wild-type strains of HSV-1. To help us better understand the genetic determinants that lead to differences in the pathogenicity of McKrae and other HSV-1 strains, we sequenced its genome. Comparing the sequence of McKrae's genome to that of strain 17 revealed that the genomes differ by at least 752 single nucleotide polymorphisms (SNPs) and 86 insertion/deletion events (indels). Although the majority of these polymorphisms reside in noncoding regions, 241 SNPs and 10 indels alter the protein-coding sequences of 58 open reading frames. Some of these variations are expected to contribute to the pathogenic phenotype of McKrae.
authors.affiliation: Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Macdonald
authors.forename: Heba H
authors.initials: HH
authors.lastname: Mostafa
authors.forename: Lynda A
authors.initials: LA
authors.lastname: Morrison
authors.forename: David J
authors.initials: DJ
authors.lastname: Davido
mesh_terms: D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D016679:Genome, Viral; D018259:Herpesvirus 1, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D014709:Vero Cells / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins