title: Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging.
abstract: A porphyrin-phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin-lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SERS based imaging.
authors.affiliation: Ontario Cancer Institute, Campbell Family Cancer Research Institute, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Natalie C M
authors.initials: NC
authors.lastname: Tam
authors.forename: Patrick Z
authors.initials: PZ
authors.lastname: McVeigh
authors.forename: Thomas D
authors.initials: TD
authors.lastname: MacDonald
authors.forename: Arash
authors.initials: A
authors.lastname: Farhadi
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
mesh_terms: D001672:Biocompatible Materials; D006046:Gold / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D053768:Metal Nanoparticles; D018613:Microscopy, Confocal; D011166:Porphyrins / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D008055:Lipids; D011166:Porphyrins; D006046:Gold