title: Association of the CD36 gene  with impaired glucose tolerance, impaired fasting glucose, type-2 diabetes, and  lipid metabolism in  essential hypertensive patients.
abstract: Essential  hypertension is a common disorder that can increase the risk of type 2 diabetes  (T2D). CD36 has been studied in patients with diabetes and hypertension  extensively; however, few studies have focused on the relationship of the CD36 gene with impaired fasting glucose (IFG)/impaired glucose tolerance (IGT)  or T2D in essential hypertension patients. To identify rs1049673 and rs1527483 in the CD36 gene conferring susceptibility to IFG/IGT and T2D, we  conducted a case-control study in 1257 essential hypertension patients among  the Han Chinese population (control: 676; IGT/IFG: 468; T2D: 113). We also  evaluated the impact of two loci on insulin sensitivity, glucose tolerance and  serum lipid. The major findings of this study were that rs1049673 was  found associated with IFG/IGT and T2D in essential hypertension patients (Pco  = 0.028; Pdom = 0.015). The rs1049673 G carriers showed  significant higher Glu0 (βdom =  0.08 (0.01~0.16), Pdom = 0.045) and Lp(a) (βco = 0.04  (0.002~0.07), Pco = 0.041; βdom = 0.06 (0.01~0.12), Pdom = 0.032), and  lower HDL by the linear regression with the adjustment for gender, age, BMI,  and mean blood pressures. These findings provided evidence that the CD36 gene  may play some role in the pathogenesis of IFG/IGT and T2D in essential  hypertension patients.
authors.affiliation: State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: X O
authors.initials: XO
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: P J
authors.initials: PJ
authors.lastname: Gao
authors.forename: D L
authors.initials: DL
authors.lastname: Zhu
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D018955:CD36 Antigens / Q000235:genetics*; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D005215:Fasting / Q000097:blood; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000235:genetics*; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D001786:Blood Glucose; D018955:CD36 Antigens; D008055:Lipids