title: Molecularly imprinted photonic polymer as an optical sensor to detect chloramphenicol.
abstract: An inverse opal photonic crystal sensor that could specifically detect chloramphenicol (CAP) in a label-free way was introduced in the current research. A colloidal crystal template was first prepared from monodisperse SiO(2) nanospheres. Precursors with different compositions were infused into the void spaces of the respective templates and aggregated. The template and the imprinted CAP were removed, and a molecularly imprinted photonic polymer (MIPP) with numerous nanocavities derived from the SiO(2) template was prepared. The MIPP could specifically recognize the target CAP. The results showed that the embedding and transporting of CAP could change the reflection peak intensity of the MIPP. The MIPP exhibited good responsiveness, with a detection range from 1 ng mL(-1) to 1 μg mL(-1) of CAP. The MIPP response time was 8 min upon its addition to CAP at a concentration of 10 ng mL(-1), which is shorter than that of other methods. After repeated use, the MIPP maintained a good performance and detection capacity. Thus, the results prove that the novel sensor could specifically detect CAP in a simple, time-saving, and low-cost manner.
authors.affiliation: Institute of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Zhou
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.forename: Jianqing
authors.initials: J
authors.lastname: Liu
authors.forename: Chun
authors.initials: C
authors.lastname: Guo
authors.forename: Yuan
authors.initials: Y
authors.lastname: Peng
authors.forename: Jialei
authors.initials: J
authors.lastname: Bai
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Jianwei
authors.initials: J
authors.lastname: Dong
authors.forename: Na
authors.initials: N
authors.lastname: Gao
authors.forename: BaoAn
authors.initials: B
authors.lastname: Ning
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Gao
mesh_terms: D002701:Chloramphenicol / Q000032:analysis*; D000432:Methanol / Q000737:chemistry; D054802:Molecular Imprinting; D049329:Nanostructures / Q000737:chemistry; D017785:Photons; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D011108:Polymers; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D002701:Chloramphenicol; D012822:Silicon Dioxide; D000432:Methanol