title: Oxaliplatin-induced lung toxicity. Case report and review of the literature.
abstract: Rapidly developing pulmonary fibrosis associated with the use of the anti-cancer drug oxaliplatin has been reported mainly by Asiatic literature as isolate case reports. This rare but potentially fatal side effect has neither identified risk factors nor established treatment guideline. We report here a new clinical case concerning a patient with advanced gastric cancer treated with the oxaliplatin-based FOLFOX regimen along with a review of the literature as well as a discussion of emerging experimental treatment mainly based on imatinib.
authors.affiliation: UO di Oncologia, Fondazione Poliambulanza, Brescia, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Prochilo
authors.forename: Chiara
authors.initials: C
authors.lastname: Abeni
authors.forename: Paola
authors.initials: P
authors.lastname: Bertocchi
authors.forename: Alberto
authors.initials: A
authors.lastname: Zaniboni
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001549:Benzamides; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000068877:Imatinib Mesylate; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D011743:Pyrimidines / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D001549:Benzamides; D009944:Organoplatinum Compounds; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000077150:Oxaliplatin; D000068877:Imatinib Mesylate; D002955:Leucovorin; D005472:Fluorouracil