title: Anticomplementary activity of oleanane-type triterpenes from the roots of Aceriphyllum rossii.
abstract: To gain a better understanding of the anticomplement activity of triterpenoids, the complement activity of five unusual oleanane-type triterpenoids, bearing a carboxyl group at the C-29 position, were estimated against the classical pathway of a complementary system. The five triterpenoids were obtained from the roots of Aceriphyllum rossii (Saxifragaceae), and were determined to be aceriphyllic acids B-E (1-4) and K (5). Of the isolated compounds, compounds 1, 2 and 5 showed anticomplement activities, with IC(50) values of 328.4, 77.5 and 348.6 μM, respectively, whereas, compounds 3 and 4 were inactive. This showed that a carboxyl group at the C-23 position and an α-configuration of a hydroxyl group at the C-3 position in the olean-29-carboxylic acid triterpenoids seemed to play an important role in the anticomplement activity of human serum against erythrocytes.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea. bsmin@cu.ac.kr
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D003171:Complement Pathway, Classical / Q000187:drug effects*; D003165:Complement System Proteins / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal; D031995:Saxifragaceae / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D007155:Immunologic Factors; D010936:Plant Extracts; D009828:Oleanolic Acid; D003165:Complement System Proteins