title: Do the paramedian tract neurons in pons take a role as a vertical neural integrator in humans?
abstract: Impairment of gaze holding mechanism and gaze-evoked nystagmus (GEN) in the vertical plane due to a focal brain lesion is usually caused by a failure of the vertical neural integrator, which is known to be localized in the interstitial nucleus of the Cajal in the upper midbrain. We report a patient with hemorrhagic stroke involving the paramedian pontine tegmentum who presented with vertical GEN due to a failure of vertical gaze holding mechanism and unilateral internuclear ophthalmoplegia. The possible structure taking a role as a vertical neural integrator in this patient might be the paramedian tract (PMT) neuron.
authors.affiliation: Department of Neurology, Keimyung University School of Medicine, South Korea.
authors.forename: Hyung
authors.initials: H
authors.lastname: Lee
authors.forename: Hyon-Ah
authors.initials: HA
authors.lastname: Yi
authors.forename: Hyun-Ah
authors.initials: HA
authors.lastname: Kim
mesh_terms: D007839:Functional Laterality / Q000502:physiology; D006470:Hemorrhage / Q000150:complications / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology*; D009759:Nystagmus, Pathologic / Q000473:pathology*; D015835:Ocular Motility Disorders / Q000209:etiology* / Q000473:pathology*; D020521:Stroke / Q000150:complications / Q000473:pathology; D013681:Tegmentum Mesencephali / Q000473:pathology*