title: Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
abstract: BACKGROUND
  Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.
  
  
  METHODS
  A total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.
  
  
  RESULTS
  For subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.
  
  
  CONCLUSIONS
  The present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
authors.affiliation: Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. akokaze@med.showa-u.ac.jp
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Kokaze
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Kanae
authors.initials: K
authors.lastname: Karita
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshida
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimada
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Ohtsu
authors.forename: Takako
authors.initials: T
authors.lastname: Shirasawa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ochiai
authors.forename: Masao
authors.initials: M
authors.lastname: Satoh
authors.forename: Masayasu
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hoshino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takashima
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D050171:Dyslipidemias / Q000097:blood / Q000209:etiology / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D012907:Smoking / Q000009:adverse effects*
chemical_list: D004272:DNA, Mitochondrial; D008055:Lipids