title: [Role of dopamine D1- and D2-receptors in the delta1-opioidergic immunostimulation].
abstract: The study has shown that activation of delta1-opioid receptors by a highly selective peptide agonist DPDPE (100 microg/kg) results in a significant increase of the immune response to antigen (SRBC, 5 x 10(8)) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D1-receptors, and selective D2-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. Comparison of effects of the antagonists suggests that delta1-opioidergic immunostimulation has more significant impact due to involvement of dopamine D1-receptors.
authors.forename: M A
authors.initials: MA
authors.lastname: Cheĭdo
authors.forename: M M
authors.initials: MM
authors.lastname: Gevorgian
mesh_terms: D000818:Animals; D018492:Dopamine Antagonists / Q000378:metabolism / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D020881:Enkephalin, D-Penicillamine (2,5)- / Q000378:metabolism / Q000494:pharmacology; D006220:Haloperidol / Q000378:metabolism / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D007110:Immunity, Active / Q000187:drug effects; D007114:Immunization; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000276:immunology; D017448:Receptors, Dopamine D2 / Q000276:immunology; D017465:Receptors, Opioid, delta / Q000276:immunology*
chemical_list: D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D000949:Histocompatibility Antigens Class II; D047908:Intracellular Signaling Peptides and Proteins; D018377:Neurotransmitter Agents; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017465:Receptors, Opioid, delta; D020881:Enkephalin, D-Penicillamine (2,5)-; D006220:Haloperidol