title: Tracking cell lineage and fate into cerebellar circuits.
abstract: Understanding how cells from different neuronal and glial lineages contribute to functional circuits has been complicated by the difficulty in tracking cells as they integrate into brain circuits. Sudarov et al. (J Neurosci 31(30):11055-11069, 2011) used a powerful genetics-based lineage marking approach to birth date ventricular zone-derived cells in the mouse cerebellum. The authors use their novel tools to elucidate the spatial and temporal dynamics of how distinct ventricular zone lineages are generated and assemble into the cerebellar microcircuitry. In this journal club, we discuss and evaluate the author's major findings.
authors.affiliation: Department of Pathology & Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, Houston, TX, 77030, USA. reeber@bcm.edu
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Reeber
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: O'Donovan
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D019521:Body Patterning; D002531:Cerebellum / Q000166:cytology*; D005260:Female; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins