title: PLA nanoparticles coated with a β-cyclodextrin polymer shell: preparation, characterization and release kinetics of a hydrophobic compound.
abstract: The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core-shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) and serves as a nanocontainer to accommodate BP. The shell is constituted of a β-cyclodextrin polymer (Poly-β-CD) which ensures the control of BP release through non-covalent host-guest interactions. Studies were focused on the preparation, physico-chemical analysis of the BP-loaded NPs and on the elucidation of the release mechanisms. The main features which are the slow kinetics, the dilution-induced release and the total release of encapsulated BP are in good agreement with a mechanism mainly controlled by diffusion of BP and by its binding with the β-CDs cavities present at the surface of NPs.
authors.affiliation: Institut de Chimie et des Matériaux Paris Est, UMR 7182 CNRS, Université Paris Est, Equipe Systèmes Polymères Complexes, 2-8 rue Henri Dunant, 94320 Thiais, France.
authors.forename: Amani
authors.initials: A
authors.lastname: El Fagui
authors.forename: Catherine
authors.initials: C
authors.lastname: Amiel
mesh_terms: D001577:Benzophenones / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D011091:Polyesters; D011108:Polymers; D047392:beta-Cyclodextrins; D019344:Lactic Acid; C033616:poly(lactide); C047723:benzophenone; C031215:betadex