title: [Study on the pharmacokinetics of ginkgolide B for injection in rats].
abstract: OBJECTIVE
  To study the pharmacokinetics of ginkgolide B for injection in rats.
  
  
  METHODS
  The serum concentration of ginkgolide B was determined by LC-MS and calculate its parameter of pharmacokinetics via DAS2.0 software.
  
  
  RESULTS
  After intravenous of 0.75, 3.75 and 14.0 mg/kg ginkgolide B, parameters of pharmacokinetics of ginkgolide B were: Tmax were all (0.083 +/- 0) h, Cmax were (422.312 +/- 14.203), (1608.467 +/- 226.677), (1987.036 +/- 237.202) microg/L, AUC0-1 were (533.833 +/- 114.943), (1786.029 +/- 137.066), (1943.44 +/- 415.892) microg x h/L.
  
  
  CONCLUSIONS
  Ginkgolide B has three compartment model in rats.
authors.affiliation: Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China. zxtcpu@yahoo.com.cn
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zhang
authors.forename: Hao-Yan
authors.initials: HY
authors.lastname: Jiao
authors.forename: Qi-Liang
authors.initials: QL
authors.lastname: Suo
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D020441:Ginkgo biloba / Q000737:chemistry*; D046934:Ginkgolides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D007783:Lactones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D013058:Mass Spectrometry; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B