title: [The influence of long-term monosodium glutamate feeding on the structure of rats pancreas].
abstract: The influence of prolonged administration of monosodium glutamate (MSG) on pancreas in rats was studied. It was established that 30-days feeding by MSG in the doses 15 to 30 mg/kg (equivalent to 1 and 2 g/person) leads to necrotic, necrobiotic and degenerative changes in exocrine and endocrine cells, leukocytic and lymphoid infiltration, perivascular and interstitial fibrosis, edema and discirculatory disorders. Introduction of sodium glutamate increases the cross-sectional area of nuclei ofexocrine and endocrine cells, indicating intensification of synthetic processes in the cells of the pancreas and reduces the cross-sectional area of exocrine pancreatic cells, which is a sign of stimulation of secretory processes in exocrine cells. The changes described are characteristic of the acute pancreatitis. It is concluded that the maximum daily dose of food supplements containing glutamic acid and its salts should be reviewed because of their adverse effects on the pancreas. It is concluded that the maximum dose of MSG should be reconsidered taking into account its influence on the pancreas.
authors.forename: I V
authors.initials: IV
authors.lastname: Leshchenko
authors.forename: V H
authors.initials: VH
authors.lastname: Shevchuk
authors.forename: T M
authors.initials: TM
authors.lastname: Falalieieva
authors.forename: T V
authors.initials: TV
authors.lastname: Beregova
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D055098:Endocrine Cells / Q000187:drug effects / Q000473:pathology; D005355:Fibrosis / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D005421:Flavoring Agents / Q000009:adverse effects*; D008297:Male; D008853:Microscopy; D008867:Microtomy; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D016612:Paraffin Embedding; D051381:Rats; D012970:Sodium Glutamate / Q000009:adverse effects*
chemical_list: D005421:Flavoring Agents; D012970:Sodium Glutamate