title: "Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations.
abstract: The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Aβ and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.
authors.affiliation: Department of Chemistry, The City University of New York at College of Staten Island, 2800 Victory Boulevard, Staten Island, New York, 10314, USA.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Dolai
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Christopher
authors.initials: C
authors.lastname: Corbo
authors.forename: Chong
authors.initials: C
authors.lastname: Sun
authors.forename: Saadyah
authors.initials: S
authors.lastname: Averick
authors.forename: Dinali
authors.initials: D
authors.lastname: Obeysekera
authors.forename: Mina
authors.initials: M
authors.lastname: Farid
authors.forename: Alejandra
authors.initials: A
authors.lastname: Alonso
authors.forename: Probal
authors.initials: P
authors.lastname: Banerjee
authors.forename: Krishnaswami
authors.initials: K
authors.lastname: Raja
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000138:chemical synthesis / Q000378:metabolism; D002478:Cells, Cultured; D003474:Curcumin / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism*; D005690:Galactose / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D051379:Mice; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D016875:tau Proteins; D003474:Curcumin; D005690:Galactose