title: Biomimetic aerobic oxidation of amino alcohols to lactams.
abstract: The right path: N-protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91, Stockholm, Sweden.
authors.forename: Beneesh P
authors.initials: BP
authors.lastname: Babu
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Endo
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D000332:Aerobiosis; D000605:Amino Alcohols / Q000737:chemistry* / Q000378:metabolism; D032701:Biomimetics; D002384:Catalysis; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000605:Amino Alcohols; D007769:Lactams; D009942:Organometallic Compounds