title: Hydroxyapatites and europium(III) doped hydroxyapatites as a carrier of silver nanoparticles and their antimicrobial activity.
abstract: Hydroxyapatites (Ca10(PO4)6(OH)2 and Eu3+:Ca10(PO4)6(OH)2) were synthesized by aqueous synthesis route. Hydroxyapatites were impregnated with silver ions that were subsequently reduced. XRD, TEM, and SAED measurements were used in order to determine the crystal structure and morphology of the final products. The results showed the well crystallized hydroxyapatite grains with diameter of about 35 nm and with silver nanoparticles on their surface. The antimicrobial activity of the nanoparticles against: Staphylococcus aureus ATCC 6538 as model of the Gram-positive bacteria, Escherichia coli ATCC 11229, and Klebsiella pneumoniae ATCC 4352 as model of Gram-negative bacteria, were shown with the best activity against K. pneumoniae. These nanocomposite powders can be a promising antimicrobial agent and a fluorescent material for biodetection due to their optical and bioactive properties.
authors.affiliation: Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland.
authors.forename: Rafal J
authors.initials: RJ
authors.lastname: Wiglusz
authors.forename: Anna
authors.initials: A
authors.lastname: Kedziora
authors.forename: Anna
authors.initials: A
authors.lastname: Lukowiak
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Doroszkiewicz
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Strek
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005063:Europium / Q000008:administration & dosage / Q000737:chemistry*; D006882:Hydroxyapatites / Q000008:administration & dosage / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D007711:Klebsiella pneumoniae / Q000187:drug effects; D049449:Luminescence; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006882:Hydroxyapatites; D007477:Ions; D012834:Silver; D005063:Europium