title: Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors.
abstract: An α-cyclodextrin-[60]fullerene conjugate with a flexible linker at the secondary face of α-cyclodextrin has been prepared, which displays significant water solubility and, more importantly, acts as a new class of HCV entry inhibitor with IC(50) at 0.17 μM level.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
authors.forename: Su-long
authors.initials: SL
authors.lastname: Xiao
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Yi-yun
authors.initials: YY
authors.lastname: Peng
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Matthieu
authors.initials: M
authors.lastname: Sollogoub
authors.forename: Pierre
authors.initials: P
authors.lastname: Sinaÿ
authors.forename: Yong-min
authors.initials: YM
authors.lastname: Zhang
authors.forename: Li-he
authors.initials: LH
authors.lastname: Zhang
authors.forename: De-min
authors.initials: DM
authors.lastname: Zhou
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D037741:Fullerenes / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D003505:Cyclodextrins; D037741:Fullerenes; C069837:fullerene C60