title: Total synthesis of 7-deoxy-6-O-methylfusarentin featuring a chelation-controlled 1,3-Reetz-Keck-type allylation.
abstract: The total synthesis of 7-deoxy-6-O-methylfusarentin (1) and a formal synthesis of 7-deoxy-6,8-O-dimethylfusarentin (2) has been successfully achieved in 10 steps. The described tactic underscores a diastereoselective strategy which incorporates a single acyclic reaction based on the initial stereocenter by means of a 1,3-chelation-controlled Reetz-Keck-type allylation.
authors.affiliation: Department of Chemistry, 250 Hackberry Lane, The University of Alabama, Tuscaloosa, Alabama 35487-0336, USA.
authors.forename: Timothy N
authors.initials: TN
authors.lastname: Trotter
authors.forename: Aymara M M
authors.initials: AM
authors.lastname: Albury
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jennings
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D002867:Chromones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: C577183:7-deoxy-6-O-methylfusarentin; D000438:Alcohols; D000475:Alkenes; D002867:Chromones