title: The association between coronary artery calcification progression and loss of bone density in non-dialyzed CKD patients.
abstract: BACKGROUND
  Coronary artery calcification (CAC) and low bone density are coexisting deleterious conditions commonly shared by chronic kidney disease (CKD) patients. In the present study, we aimed to investigate whether the progression of CAC was associated with overtime reduction in bone density in non-dialyzed CKD patients.
  
  
  METHODS
  This is a prospective study of 24 months including 72 non-dialyzed CKD patients Stages 2 - 4 (age 57.6 ± 10.3 years, 62% male, 22% diabetics). CAC and vertebral bone density (VBD) were measured by computed tomography.
  
  
  RESULTS
  At baseline, 46% of the patients had CAC (calcified group) and calcification was not identified in 54% of the patients (non-calcified group). The calcified group was older, predominantly male, and had lower VBD in comparison to non-calcified group. CAC progression was observed only in the calcified group (91% of the patients increased calcium score). The multiple regression analysis revealed loss of VBD as the independent determinant of CAC progression in these patients.
  
  
  CONCLUSIONS
  CAC progression was associated with loss of VBD in non-dialyzed CKD patients.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Federal University of São Paulo, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Watanabe
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Lemos
authors.forename: Aluizio B
authors.initials: AB
authors.lastname: Carvalho
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rochitte
authors.forename: Raul D
authors.initials: RD
authors.lastname: Santos
authors.forename: Sérgio A
authors.initials: SA
authors.lastname: Draibe
authors.forename: Maria Eugênia
authors.initials: ME
authors.lastname: Canziani
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D003324:Coronary Artery Disease / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D013131:Spine / Q000378:metabolism; D061205:Vascular Calcification / Q000209:etiology*