title: [Association between gene polymorphisms and myocardial infarction in Han Chinese of Yunnan province].
abstract: OBJECTIVE
  To determine frequencies of genetic polymorphisms of coagulation factor VII (FVII), coagulation factor FXII (FXII), fibrinogen (FBG) and 9p21 in ethnic Han Chinese from Yunnan province, and to assess the association between such polymorphisms and onset of myocardial infarction (MI).
  
  
  METHODS
  One hundred and forty-two patients with MI and 192 healthy controls were analyzed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and pyrosequencing were used to determine the genotypes of FVII, FXII, FBG and 9p21.
  
  
  RESULTS
  No significant difference was found in the frequencies of R353Q, 5'F7, C46T, -148C/T, rs1333049 and rs4977574 loci between the two groups (P> 0.05). However, the frequencies of AA of -455G/A, T and TT of rs1333040, T and TT of rs10116277 and G and GG of rs2383207 were significantly higher in MI group compared with the controls (P< 0.05), whilst the frequencies of CT of rs1333040 and GT of rs10116277 were significantly lower in MI group compared with the controls (P<0.05).
  
  
  CONCLUSIONS
  Polymorphisms of FVII, FXII, -148C/T of FBG and rs1333049 of 9p21 were not associated with myocardial infarction. Polymorphisms of -455G/A of FBG and rs1333040, rs10116277 and rs2383207 of 9p21 may be associated with MI in ethnic Han Chinese from Yunnan province.
authors.affiliation: Department of Medical Genetics, Chinese Academy of Medical Sciences, Kunming, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Qi
authors.forename: Jian-mei
authors.initials: JM
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Huang
authors.forename: Ke-qin
authors.initials: KQ
authors.lastname: Lin
authors.forename: Jia-you
authors.initials: JY
authors.lastname: Chu
authors.forename: Zhao-qing
authors.initials: ZQ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005167:Factor VII / Q000235:genetics; D005174:Factor XII / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005167:Factor VII; D005174:Factor XII; D005340:Fibrinogen