title: Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents.
abstract: The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4'-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
authors.affiliation: Institute of Biochemistry, University of Baluchistan, Quetta, Pakistan.
authors.forename: Yasser M S A
authors.initials: YM
authors.lastname: Al-Kahraman
authors.forename: Masoom
authors.initials: M
authors.lastname: Yasinzai
authors.forename: Girija S
authors.initials: GS
authors.lastname: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005670:Fusarium / Q000187:drug effects / Q000254:growth & development; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000254:growth & development; D018320:Leishmania major / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D006835:Hydrazones; D007659:Ketones