title: Association of Hepatitis A exposure and TIM-1 with childhood allergic asthma.
abstract: BACKGROUND
  Hepatitis A virus (HAV) receptor (TIM-1) polymorphism plays an important role in asthma and autoimmune diseases. Objective. To analyze the association of TIM-1 polymorphism and HAV infection with childhood allergic asthma in Southwest China.
  
  
  METHODS
  TIM-1 exon 4 (157insMTTTVP) and two polymorphism loci, -416G>C and -1454G>A, in the HAV receptor promoter region were studied. Polymerase chain reaction (PCR) was used to test the genotypes of three polymorphism loci among 579 cases of asthma and 524 controls. The HAV infection status was determined in a case-control study with stratified analysis.
  
  
  RESULTS
  HAV exposure associated with childhood allergic asthma in the study population was compared with controls (odds ratio (OR) = 0.181, 95% confidence interval (CI) 0.126-0.260, p < .001). The -416G>C polymorphism was associated with asthma (OR = 1.384, 95% CI 1.148-1.669, p < .001), but the insertion variant 157delMTTTVP of exon 4 and the -1454G>A polymorphism were not.
  
  
  CONCLUSIONS
  Our results indicated that the -416G>C polymorphism of the TIM-1 gene is associated with childhood allergic asthma, providing a better understanding of the pathogenesis of the allergic asthma among children aged below 15 years in Southwest China.
authors.affiliation: Department of Pediatrics, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Chen
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Zhao
authors.forename: Nian-Hai
authors.initials: NH
authors.lastname: He
authors.forename: Qin
authors.initials: Q
authors.lastname: Gui
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Xiong
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Zhou
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006506:Hepatitis A / Q000150:complications*; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011991:Receptors, Virus / Q000235:genetics*
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus