title: Cervarix®: a bivalent vaccine against HPV types 16 and 18, with cross-protection against other high-risk HPV types.
abstract: Cervical cancer is the third most common cancer in women worldwide and often affects women under 40 years of age with young families. Vaccination against HPV is a major advancement, as it offers primary prevention against the infectious agent that is the main cause of the disease. The bivalent AS04-adjuvanted prophylactic HPV vaccine provides high efficacy against disease associated with HPV 16 and 18, as well as significant cross-protection against some HPV types not included in the vaccine. Protection against HPV 45 may be particularly important, as it is relatively more common in adenocarcinoma. The vaccine's antibody response profile suggests a long duration of immunity. Safety data have been reassuring, which is not unexpected, given that the vaccine is composed of virus-like particles, rather than being a live-virus vaccine.
authors.affiliation: Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK. a.szarewski@qmul.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Szarewski
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D056738:Cross Protection; D005260:Female; D052162:Human papillomavirus 16 / Q000276:immunology* / Q000472:pathogenicity; D052161:Human papillomavirus 18 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008050:Lipid A / Q000008:administration & dosage / Q000031:analogs & derivatives; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control* / Q000821:virology; D055815:Young Adult
chemical_list: C532963:ASO4 mixture; D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D008050:Lipid A; D053918:Papillomavirus Vaccines; C510352:human papillomavirus vaccine, L1 type 16, 18; D000536:Aluminum Hydroxide