title: Plasma resistin,  associated with single nucleotide polymorphism -420, is correlated with  C-reactive protein in Chinese Han patients with spontaneous basal ganglia  hemorrhage.
abstract: We  examined a possible relationship -420C>G SNP of the resistin gene with plasma  resistin and C-reactive protein concentrations in intracerebral hemorrhage.  Three hundred and forty-four Chinese Han patients with intracerebral hemorrhage  and 344 age- and gender-matched healthy controls were included in our study.  Plasma resistin and C-reactive concentrations were measured and SNP -420C>G  was genotyped. The genotype frequencies in controls and patients were not  significantly different (P = 0.672). Plasma resistin and C-reactive protein  levels were significantly different between the SNP -420C>G genotypes, even  after adjustment for age, gender and body mass index. The common homozygote  (C-C) had the lowest resistin and C-reactive protein plasma concentrations; the  plasma resistin and C-reactive protein concentrations in the heterozygote (C-G)  and the rare allele homozygote (G-G) did not differ significantly. Plasma  resistin levels were significantly associated with plasma C-reactive protein  level. We conclude that SNP -420C>G of the resistin gene could be involved  in the inflammatory component of intracerebral hemorrhage through enhanced  production of resistin.
authors.affiliation: Department of Neurosurgery, First Hangzhou Municipal People's Hospital, Nanjing Medical University, Hangzhou, China.
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Dong
authors.forename: Q
authors.initials: Q
authors.lastname: Du
authors.forename: W-H
authors.initials: WH
authors.lastname: Yu
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhu
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Che
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: S-B
authors.initials: SB
authors.lastname: Yang
authors.forename: J-F
authors.initials: JF
authors.lastname: Wen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D020145:Basal Ganglia Hemorrhage / Q000097:blood / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D052243:Resistin / Q000097:blood* / Q000235:genetics*
chemical_list: D052243:Resistin; D002097:C-Reactive Protein