title: Correlation among the toxicity profiling (28-days repeated oral dose toxicity), toxicokinetics and tissue distribution data of ulifloxacin, the active metabolite of prulifloxacin in Wistar albino rats.
abstract: This experiment was designed to investigate correlation among 28-days repeated oral dose toxicity, toxicokinetics and tissue distribution data of ulifloxacin (active metabolite of prulifloxacin) in Wistar albino rats. Prulifloxacin was administered for 28-days in rats at 0, 100, 200, 400mg/kg/day followed by 14-days recovery period. Simultaneously different toxicokinetic parameters and tissue distributions of ulifloxacin was examined by LC-MS/MS method. Plasma levels and tissue concentrations of ulifloxacin were increased with dose-related manner. Ulifloxacin was also distributed to many tissues, and concentration in lungs nearly equivalent to the plasma concentration. Based on these results it was concluded that long-term repeated dose of prulifloxacin may produce different blood parameters abnormality, liver damage, stomach ulcer, joint damage and dysfunction of lungs in rats which relates to high tissue distribution and accumulation of ulifloxacin in these tissues. These findings help in management of prulifloxacin induced adverse effects by appropriate dose selection in clinical practice.
authors.affiliation: Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Utpal
authors.initials: U
authors.lastname: Nandi
authors.affiliation: Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
authors.forename: Bikash
authors.initials: B
authors.lastname: Roy
authors.affiliation: Calcutta National Medical College, Department of Pathology, Kolkata 700014, India.
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Das
authors.affiliation: Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: proftkpal@gmail.com.
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Pal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D001168:Arthritis / Q000139:chemically induced / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000209:etiology; D004148:Dioxolanes / Q000493:pharmacokinetics* / Q000633:toxicity*; D005260:Female; D024841:Fluoroquinolones / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000633:toxicity*; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D010879:Piperazines / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013582:Synovial Fluid / Q000737:chemistry; D014018:Tissue Distribution; D059551:Toxicity Tests, Subacute
chemical_list: D000900:Anti-Bacterial Agents; D004148:Dioxolanes; D024841:Fluoroquinolones; D010879:Piperazines; C074190:ulifloxacin; C074191:prulifloxacin