title: Prooxidant-antioxidant balance and antioxidized LDL antibody level values and cardiac function in patients with coronary artery disease.
abstract: OBJECTIVE
  We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD).
  
  
  METHODS
  Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients.
  
  
  RESULTS
  PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05).
  
  
  CONCLUSIONS
  Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB.
authors.affiliation: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Rahsepar
authors.forename: Asadollah
authors.initials: A
authors.lastname: Mirzaee
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moodi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Shima
authors.initials: S
authors.lastname: Tavallaie
authors.forename: Ali
authors.initials: A
authors.lastname: Eshraghi
authors.forename: Maryam-Sadat
authors.initials: MS
authors.lastname: Alavi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Khorashadizadeh
authors.forename: Hossein
authors.initials: H
authors.lastname: Pourghadamyari
authors.forename: Roghayeh
authors.initials: R
authors.lastname: Paydar
authors.forename: Maral
authors.initials: M
authors.lastname: Amini
authors.forename: Roshanak
authors.initials: R
authors.lastname: Khojasteh
authors.forename: Somayeh
authors.initials: S
authors.lastname: Mousavi
authors.forename: Maryam
authors.initials: M
authors.lastname: Sahebi
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D003324:Coronary Artery Disease / Q000276:immunology / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000906:Antibodies; D000975:Antioxidants; D015415:Biomarkers; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D017382:Reactive Oxygen Species; C099252:oxidized low density lipoprotein