title: Targeting Jab1/CSN5 in nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated head and neck cancer that is most common in eastern Asia. Epstein-Barr virus infection, environmental factors, and genetic susceptibility play important roles in NPC pathogenesis. Jab1/CSN5 is a multifunctional protein that participates in affecting integrin signaling, controlling cell proliferation and apoptosis, and regulating genomic instability and DNA repair. Correlation of Jab1/CSN5 overexpression with poor prognosis for NPC provides evidence that it is involved in the tumorigenic process. In this review, we highlight recent advances in studies of the oncogenic role of Jab1/CSN5 in NPC and its potential as a therapeutic target for this cancer.
authors.affiliation: Department of Systems Biology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Yunbao
authors.initials: Y
authors.lastname: Pan
authors.forename: Francois X
authors.initials: FX
authors.lastname: Claret
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D000075686:COP9 Signalosome Complex; D002453:Cell Cycle; D049109:Cell Proliferation; D002945:Cisplatin / Q000494:pharmacology; D004249:DNA Damage; D004260:DNA Repair; D018450:Disease Progression; D015870:Gene Expression / Q000187:drug effects; D042822:Genomic Instability; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex; D002945:Cisplatin