title: Disruption of atherosclerotic neointima seven years after bare metal stent deployment.
abstract: A 58-year-old male with a history of prior myocardial infarction, hypertension, and dyslipidemia was admitted due to deteriorating exertional angina. A bare metal stent (Multilink plus™, GUIDANT Corporation, Santa Clara, CA, USA) had been implanted into the proximal left anterior descending artery because of ST-elevation myocardial infarction 7 years earlier. Optical coherence tomography (OCT) showed a disruption of the atherosclerotic neointima overlying the stent. Intravascular imaging studies and pathological studies have shown that neointima within a bare-metal stent often transform into atherosclerotic tissue during an extended period of time. In the current report, OCT demonstrated that a disruption of the atherosclerotic neointima has the potential to cause the development of unstable clinical features. OCT examinations therefore help to understand the pathogenesis of acute coronary syndrome after stent implantation.
authors.affiliation: Department of Medicine, Division of Cardiology, Hepatology, Geriatrics and Integrated Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Inami
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takano
authors.forename: Kohji
authors.initials: K
authors.lastname: Kato
authors.forename: Asuka
authors.initials: A
authors.lastname: Yoshida
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Nakamura
authors.forename: Koji
authors.initials: K
authors.lastname: Murai
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Tokita
authors.forename: Gen
authors.initials: G
authors.lastname: Takagi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takano
authors.forename: Kuniya
authors.initials: K
authors.lastname: Asai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasutake
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D000787:Angina Pectoris / Q000209:etiology; D050197:Atherosclerosis / Q000209:etiology*; D023903:Coronary Restenosis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000150:complications*; D012422:Rupture, Spontaneous; D015607:Stents / Q000009:adverse effects*; D041623:Tomography, Optical Coherence