title: [The therapeutic effect of propranolol with 1064 nm Nd: YAG laser on proliferating hemangioma in body surface].
abstract: OBJECTIVE
  To observe the therapeutic effect of propranolol with 1 064 nm Nd:YAG laser on proliferating hemangioma in body surface.
  
  
  METHODS
  97 patients with proliferating hemangiomas in body surface were randomly assigned to three groups: A group (32 patients were treated by propranolol with 1064 nm Nd:YAG laser), B group (35 patients were treated by 1064 nm Nd:YAG laser), C group (30 patients were treated by propranolol). Their visual analog scores, clinical outcomes and adverse events were compared respectively.
  
  
  RESULTS
  18 weeks later, A group had a mean visual analog score of 65.50 +/- 16.55, compared with 54.03 +/- 20.13 in B group, 28.08 +/- 30.34 in C group (P < 0.05); 24 weeks later, the mean visual analog scores of three groups were 76.88 +/- 19.05, 63.89 +/- 19.43 and 45.48 +/- 31.86 (P < 0.05). After 24 weeks' treatment, 9 cases (28.1%) in A group, 3 cases (8.6%) in B group, 1 cases (4.0%) in C group obtained complete healing (P < 0.05). To effect of adverse events in body surface, the mean score of B group was higher than the scores of A group and C group (P < 0.05).
  
  
  CONCLUSIONS
  Propranolol with 1064 nm Nd:YAG laser is effective and safe in the treatment of proliferating hemangioma.
authors.affiliation: Hubei Maternal and Child Health Hospital, Department of Cosmetology, Wuhan 430070, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
authors.forename: Bo
authors.initials: B
authors.lastname: Duan
authors.forename: Chun-mei
authors.initials: CM
authors.lastname: Zhou
authors.forename: Hao
authors.initials: H
authors.lastname: Gong
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D006391:Hemangioma / Q000628:therapy*; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000628:therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D011433:Propranolol