title: Electrostatic-spray ionization mass spectrometry.
abstract: An electrostatic-spray ionization (ESTASI) method has been used for mass spectrometry (MS) analysis of samples deposited in or on an insulating substrate. The ionization is induced by a capacitive coupling between an electrode and the sample. In practice, a metallic electrode is placed close to but not in direct contact with the sample. Upon application of a high voltage pulse to the electrode, an electrostatic charging of the sample occurs leading to a bipolar spray pulse. When the voltage is positive, the bipolar spray pulse consists first of cations and then of anions. This method has been applied to a wide range of geometries to emit ions from samples in a silica capillary, in a disposable pipet tip, in a polymer microchannel, or from samples deposited as droplets on a polymer plate. Fractions from capillary electrophoresis were collected on a polymer plate for ESTASI MS analysis.
authors.affiliation: Laboratoire d'Electrochimie Physique et Analytique, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Liang
authors.initials: L
authors.lastname: Qiao
authors.forename: Romain
authors.initials: R
authors.lastname: Sartor
authors.forename: Natalia
authors.initials: N
authors.lastname: Gasilova
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.forename: Elena
authors.initials: E
authors.lastname: Tobolkina
authors.forename: Baohong
authors.initials: B
authors.lastname: Liu
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Girault
mesh_terms: D000803:Angiotensin I / Q000032:analysis; D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D004566:Electrodes; D011108:Polymers / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D055672:Static Electricity
chemical_list: D000838:Anions; D002412:Cations; D011108:Polymers; D000803:Angiotensin I