title: Novel insights into the role of S100A8/A9 in skin biology.
abstract: S100A8 and S100A9 belong to the damage-associated molecular pattern molecules. They are upregulated in a number of inflammatory skin disorders. Owing to their abundance in myeloid cells, the main function of S100A8/A9 has been attributed to their role in inflammatory cells. However, it is becoming increasingly clear that they also exert important roles in epithelial cells. In this review, we discuss the context-dependent function of S100A8/A9 in epithelial cells and their impact on wound healing, psoriasis and other skin diseases.
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Department of Immunology, AG EXIM, Rostock, Germany. kerkhoc@uni-muenster.de
authors.forename: Claus
authors.initials: C
authors.lastname: Kerkhoff
authors.forename: Andreas
authors.initials: A
authors.lastname: Voss
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Scholzen
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Averill
authors.forename: Kurt S
authors.initials: KS
authors.lastname: Zänker
authors.forename: Karin E
authors.initials: KE
authors.lastname: Bornfeldt
mesh_terms: D040501:Calgranulin A / Q000502:physiology*; D040502:Calgranulin B / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D011565:Psoriasis / Q000503:physiopathology; D012871:Skin Diseases / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000502:physiology
chemical_list: D040501:Calgranulin A; D040502:Calgranulin B