title: [On the stability of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR)].
abstract: The objective of the present study was to determine the duration and conditions of persistence of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR) on the environmental objects. The quantitative analysis of the substance on cotton fabric specimens was carried out using the approved method of high performance liquid chromatography (HPLC) with UV detection at different time periods and envirobmental conditions. It was shown that the main factor determining the lifetime of dibenz-[b,f]-[1,4]-oxazepine on the cotton fabric is the ambient conditions. By way of example, the "open" and "closed", storage of such specimens during 300 days resulted in the decrease of the amount of substance CR to 22.5 and 79% of the initial level respectively. By the end experiment (day 600) these values lowered to 3 and 52.5% respectively. Taken together, the results of the study indicate that dibenz-[b,f]-[1,4]-oxazepine can be described as a substance resistant to environmental impacts. It is comparable in terms of stability with such known irritants as capsicum oleoresin and pelargonic acid morpholide.
authors.forename: A V
authors.initials: AV
authors.lastname: Kovalev
authors.forename: S I
authors.initials: SI
authors.lastname: Tolmachev
authors.forename: L A
authors.initials: LA
authors.lastname: Mukovskiĭ
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Khrustaleva
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003989:Dibenzoxazepines / Q000032:analysis* / Q000633:toxicity; D004355:Drug Stability; D053593:Forensic Toxicology / Q000379:methods*; D013329:Structure-Activity Relationship; D013665:Tear Gases / Q000032:analysis* / Q000633:toxicity; D013784:Textiles / Q000032:analysis; D013997:Time Factors
chemical_list: D003989:Dibenzoxazepines; D013665:Tear Gases; C036433:dibenz(b,f)(1,4)oxazepine