title: Application of the Knowledge-to-Action and Medical Research Council frameworks in the development of an osteoporosis clinical decision support tool.
abstract: OBJECTIVE
  Informatics-based knowledge translation interventions have the potential to address clinical practice and patient care, but evidence shows that they can fail, have the potential to be ineffective, function poorly, and result in medical or technology-induced errors if rushed to become an integral part of health care systems and practices. In an attempt to meet these challenges and advance the science of developing knowledge translation interventions, the objective of this study was to apply two theoretical frameworks (the Knowledge-to-Action and the Medical Research Council frameworks for complex interventions) in the development of an osteoporosis clinical decision support tool.
  
  
  METHODS
  Descriptive analysis of how the Knowledge-to-Action and Medical Research Council frameworks can be applied in the development of an osteoporosis tool.
  
  
  RESULTS
  An osteoporosis tool was developed using a seven-phase process by collapsing the "action" steps of the Knowledge-to-Action cycle and phases of the Medical Research Council framework. Analysis of this procedure informed a proposed seven-step process that may be applied by others in the development of knowledge translation tools and complex interventions.
  
  
  CONCLUSIONS
  The combined frameworks can be used to map the process for translating evidence into practice by addressing potential barriers, and anticipating how knowledge will be sustained and disseminated.
authors.affiliation: Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario M5B 1X2, Canada. monika.kastner@utoronto.ca
authors.forename: Monika
authors.initials: M
authors.lastname: Kastner
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Straus
mesh_terms: D003661:Decision Support Techniques; D019468:Disease Management; D019317:Evidence-Based Medicine / Q000379:methods*; D005194:Family Practice / Q000379:methods; D006801:Humans; D033181:Information Dissemination / Q000379:methods; D008490:Medical Informatics; D008962:Models, Theoretical; D010024:Osteoporosis; D057170:Translational Research, Biomedical / Q000379:methods*