title: Circulatory and adipose tissue leptin and adiponectin in relationship to resting energy expenditure in patients with chronic obstructive pulmonary disease.
abstract: Increases in resting energy expenditure (REE) likely contribute to weight loss in various chronic diseases. In chronic obstructive pulmonary disease (COPD), relationships between the ventilatory impairment and increased REE, and between disturbances in adipokines and weight loss were previously described. Therefore, we investigated serum levels and adipose tissue expression of leptin and adiponectin, and their relationships to REE in patients with COPD. In 44 patients with stable COPD (38 male; age 62.3+/-7.2 years), REE was assessed using indirect calorimetry. Subcutaneous adipose tissue samples were analyzed using real-time PCR. From underweight [n=9; body mass index (BMI) <20.0 kg.m(-2)], to normal weight-overweight (n=24, BMI=20.0-29.9 kg.m(-2)) and obese patients (n=11; BMI>/=30 kg.m(-2)), REE adjusted for body weight decreased (32.9+/-6.1 vs. 26.2+/-5.8 vs. 23.9+/-6.6 kcal.kg(-1).24 h(-1), p=0.006), serum levels and adipose tissue expression of leptin increased (p<0.001 for both), and serum and adipose tissue adiponectin decreased (p<0.001; p=0.004, respectively). REE was inversely related to serum and adipose tissue leptin (R=-0.547, p<0.001; R=-0.458, p=0.002), and directly to serum adiponectin (R=0.316, p=0.039). Underweight patients had increased REE compared to normal weight-overweight patients, in association with reductions in serum and adipose tissue leptin, and increased serum adiponectin, suggesting a role of adipokines in energy imbalance in COPD-related cachexia.
authors.affiliation: Department of Respiratory Medicine, Faculty of Medicine, P. J. Šafárik University and L. Pasteur University Hospital, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Brúsik
authors.forename: J
authors.initials: J
authors.lastname: Ukropec
authors.forename: P
authors.initials: P
authors.lastname: Joppa
authors.forename: B
authors.initials: B
authors.lastname: Ukropcová
authors.forename: P
authors.initials: P
authors.lastname: Skyba
authors.forename: M
authors.initials: M
authors.lastname: Baláž
authors.forename: P
authors.initials: P
authors.lastname: Pobeha
authors.forename: T
authors.initials: T
authors.lastname: Kurdiová
authors.forename: I
authors.initials: I
authors.lastname: Klimeš
authors.forename: I
authors.initials: I
authors.lastname: Tkáč
authors.forename: D
authors.initials: D
authors.lastname: Gašperíková
authors.forename: R
authors.initials: R
authors.lastname: Tkáčová
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D012146:Rest
chemical_list: D052242:Adiponectin; D020738:Leptin