title: The influence of overweight and obesity on maternal soluble fms-like tyrosine kinase 1 and its relationship with leptin during pregnancy.
abstract: We studied obesity-related differences in the relation of maternal levels of leptin to levels of soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein that influences placentation and risk of adverse pregnancy outcomes. In a prospective cohort of 286 gravidas, we measured maternal serum levels of sFlt1 and leptin at 5 time points across pregnancy. Analyses stratified on prepregnancy body mass index (<25 vs ≥25) were done using mixed linear models. The mean leptin concentrations were significantly higher in overweight/obese compared to normal-weight women, while mean sFlt1 levels in second and third trimester were significantly higher in normal weight compared to overweight/obese women. The relationship between sFlt1 and leptin differed between the 2 strata. After controlling for maternal weight, a 1 ng/mL increase in leptin was associated with an 19.4 pg/mL increase in sFlt1 (P = .01) in normal-weight women, while leptin was not associated with sFlt1 (β = 1.1, P = .75) in overweight/obese women. Such differences suggest that metabolic differences in overweight/obese women compared to their normal weight peers may differentially impact the physiologic changes during pregnancy.
authors.affiliation: Department of Family Medicine and Public Health Sciences, Division of Population Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Straughen
authors.forename: Dawn P
authors.initials: DP
authors.lastname: Misra
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Misra
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000175:diagnosis; D050177:Overweight / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy / Q000097:blood*; D011446:Prospective Studies; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020738:Leptin; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1