title: Dietary supplements for benign prostatic hyperplasia: an overview of systematic reviews.
abstract: Benign prostatic hyperplasia (BPH) is a common chronic condition in older men. The aim of this overview of systematic reviews (SRs) is to summarise the current evidence on the efficacy and adverse effects of dietary supplements for treating BPH with lower urinary tract symptoms. We searched 5 electronic databases and relevant overviews without limitations on language or publication status. Six SRs of 195 articles were included in this overview. Serenoa repens was reviewed in 3 studies and no specific effect on BPH symptoms and urinary flow measures was observed. However, β-sitosterol, Pygeum africannum and Cernilton were reviewed in one study each, and significant improvement was observed for all three. All the included compounds have mild and infrequent adverse effects. SRs on β-sitosterol, Pygeum africannum and Cernilton have not been updated since 2000, thus an update of reviews on these compounds will be necessary in the future.
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.
authors.forename: Tae-Hun
authors.initials: TH
authors.lastname: Kim
authors.forename: Hyun-Ja
authors.initials: HJ
authors.lastname: Lim
authors.forename: Myung-Sunny
authors.initials: MS
authors.lastname: Kim
authors.forename: Myeong Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D019587:Dietary Supplements / Q000009:adverse effects; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D000068218:Prunus africana / Q000009:adverse effects; D012434:Secale / Q000009:adverse effects; D028024:Serenoa / Q000009:adverse effects; D012855:Sitosterols / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014570:Urologic Diseases / Q000188:drug therapy / Q000209:etiology
chemical_list: D010936:Plant Extracts; D012855:Sitosterols; C025473:gamma-sitosterol; C010070:cernilton