title: Cytotoxic and antioxidant constituents from Garcinia subelliptica.
abstract: Two new triterpenoids, garcinielliptones Q (1) and S (3), and a new phloroglucinol, garcinielliptone R (2), were isolated from the seed of Garcinia subelliptica. Their structures were established by analysis of their spectroscopic data. Phloroglucinol, garcinielliptone FC (4) from this plant exhibited a significant increase of antiproliferative effect, while 4 combined with cisplatin significantly caused decrease of cell inhibition induced by cisplatin in NTUB1. Exposure of NTUB1 cells to 4 cotreated with cisplatin for significantly decreased the amount of reactive oxygen species (ROS) than that of the total amount generated by 4 and cisplatin. These results suggested that 4 could protect the cisplatin toxicity through reduction of ROS in NTUB1. Phloroglucinols, garcinielliptones, A (5) and F (7), and garsubelline A (6), from this plant, revealed ABTS radical cation scavenging activity and 5 displayed an inhibitory effect on xanthine oxidase. These finding showed that 5-7 may be used as antioxidants.
authors.affiliation: Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Kai-Wei
authors.initials: KW
authors.lastname: Lin
authors.forename: A-Mei
authors.initials: AM
authors.lastname: Huang
authors.forename: Shyh-Chyun
authors.initials: SC
authors.lastname: Yang
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Weng
authors.forename: Tzyh-Chyuan
authors.initials: TC
authors.lastname: Hour
authors.forename: Yeong-Shiau
authors.initials: YS
authors.lastname: Pu
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Lin
mesh_terms: D000975:Antioxidants / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D003603:Cytotoxins; D010936:Plant Extracts