title: Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance.
abstract: Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are hematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved in inflammatory responses, mainly being performed on granulocytes or CD34+ cells. Using gene expression profiling of whole blood from patients with ET (n=16), PV (n=36), and PMF (n=9), several genes involved in inflammation and immune regulation were found to be significantly deregulated. Our findings may reflect chronic inflammation to be of pathogenetic importance for the progression of these neoplasms toward the myelofibrotic end-stage and may also account for the increased frequency of second cancer in these diseases.
authors.affiliation: Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
authors.forename: Vibe
authors.initials: V
authors.lastname: Skov
authors.forename: Thomas Stauffer
authors.initials: TS
authors.lastname: Larsen
authors.forename: Mads
authors.initials: M
authors.lastname: Thomassen
authors.forename: Caroline Hasselbalch
authors.initials: CH
authors.lastname: Riley
authors.forename: Morten K
authors.initials: MK
authors.lastname: Jensen
authors.forename: Ole Weis
authors.initials: OW
authors.lastname: Bjerrum
authors.forename: Torben A
authors.initials: TA
authors.lastname: Kruse
authors.forename: Hans Carl
authors.initials: HC
authors.lastname: Hasselbalch
mesh_terms: D001773:Blood Cells / Q000166:cytology / Q000276:immunology; D020869:Gene Expression Profiling; D006801:Humans; D007157:Immunologic Surveillance / Q000235:genetics* / Q000276:immunology; D007249:Inflammation / Q000097:blood / Q000235:genetics* / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D011087:Polycythemia Vera / Q000097:blood / Q000235:genetics* / Q000276:immunology; D055728:Primary Myelofibrosis / Q000097:blood / Q000235:genetics* / Q000276:immunology; D013920:Thrombocythemia, Essential / Q000097:blood / Q000235:genetics* / Q000276:immunology; D059467:Transcriptome