title: Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2008-2010.
abstract: We present our surveillance results on imported dengue cases in Taiwan during 2008-2010. A total of 734 imported dengue patients were identified. The travelers were arriving from 18 countries, including Southeast Asia, the Indian subcontinent, South Pacific islands, and Latin America. Gene sequences from 358 dengue virus (DENV) isolates were used to perform phylogenetic analyses, thus, providing an updated view of the geographic distribution and dynamic transmission of DENV strains circulating in these countries. Our results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant DENV strains circulating in Southeast Asian countries. The DENV-3 Genotype III strain was found to be newly emerging in several Southeast Asian countries, however, the Asian genotype 2 and the Asian/American genotype of DENV-2 strains appeared to be less prevalent in Southeast Asia. Furthermore, imported dengue viruses are representative of the overall patterns of serotype/genotype frequencies of dengue outbreaks that occurred in Taiwan.
authors.affiliation: Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, Republic of China.
authors.forename: Jyh-Hsiung
authors.initials: JH
authors.lastname: Huang
authors.forename: Chien-Ling
authors.initials: CL
authors.lastname: Su
authors.forename: Cheng-Fen
authors.initials: CF
authors.lastname: Yang
authors.forename: Tsai-Ling
authors.initials: TL
authors.lastname: Liao
authors.forename: Tung-Chien
authors.initials: TC
authors.lastname: Hsu
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chang
authors.forename: Chien-Chou
authors.initials: CC
authors.lastname: Lin
authors.forename: Pei-Yun
authors.initials: PY
authors.lastname: Shu
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D003715:Dengue / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral