title: Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction.
  
  
  METHODS
  In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured.
  
  
  RESULTS
  Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer.
  
  
  CONCLUSIONS
  Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.
authors.affiliation: FMC, Dinefro - Diálises e Nefrologia - SA ,  Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: do Sameiro Faria
authors.forename: Sandra
authors.initials: S
authors.lastname: Ribeiro
authors.forename: Henrique
authors.initials: H
authors.lastname: Nascimento
authors.forename: Petronila
authors.initials: P
authors.lastname: Rocha-Pereira
authors.forename: Vasco
authors.initials: V
authors.lastname: Miranda
authors.forename: Denisa
authors.initials: D
authors.lastname: Mendonça
authors.forename: Alexandre
authors.initials: A
authors.lastname: Quintanilha
authors.forename: Elísio
authors.initials: E
authors.lastname: Costa
authors.forename: Luís
authors.initials: L
authors.lastname: Belo
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D004727:Endothelium / Q000503:physiopathology; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D006435:Renal Dialysis; D018709:Statistics, Nonparametric; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6; D008077:Lipoproteins, LDL; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D010959:Tissue Plasminogen Activator