title: 4-Methylenesterols from a sponge Theonella swinhoei.
abstract: Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Jheng-Kun
authors.initials: JK
authors.lastname: Guo
authors.affiliation: Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan.
authors.forename: Ching-Ying
authors.initials: CY
authors.lastname: Chiang
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Wen-Been
authors.initials: WB
authors.lastname: Chang
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013261:Sterols