title: Intake of liquid and solid sucrose in relation to changes in body fatness over 6 years among 8- to 10-year-old children: the European Youth Heart Study.
abstract: OBJECTIVE
  To examine if intake of soft drinks is more closely associated with weight gain than other energy sources and if these associations are mediated through differences in energy intake or insulin level.
  
  
  METHODS
  Data derived from the Danish part of the European Youth Heart Study (n = 359). Height, weight, and waist circumference (WC) were measured in 1997-1998 and again in 2003-2004.
  
  
  RESULTS
  Intake of liquid sucrose was associated with changes in waist circumference (ΔWC) (β = 0.226, p = 0.07, R(2) = 0.17) as well as BMI z-scores (ΔBMI(z)) (β = 0.031, p = 0.05, R(2) = 0.30). Associations attenuated slightly after adjusting for energy intake, but were substantially reduced when adjusting for insulin. Adjustment for both insulin and energy intake attenuated the effect of soft drinks intake on ΔBMI(z), but not on ΔWC.
  
  
  CONCLUSIONS
  Liquid sucrose seemed more clearly associated with ΔWC and ΔBMI(z) than other energy sources. For ΔWC, the association seemed to be based on decreases in insulin sensitivity rather than increases in energy intake, whereas for ΔBMI(z) the association seemed to be based on both increases in energy intake and decreases in insulin sensitivity.
authors.affiliation: Research Unit for Dietary Studies, Institute of Preventive Medicine, Copenhagen Capital Region, Copenhagen University Hospitals, Frederiksberg, Denmark. njo@ipm.regionh.dk
authors.forename: Nanna Julie
authors.initials: NJ
authors.lastname: Olsen
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Andersen
authors.forename: Niels
authors.initials: N
authors.lastname: Wedderkopp
authors.forename: Peter Lund
authors.initials: PL
authors.lastname: Kristensen
authors.forename: Berit Lilienthal
authors.initials: BL
authors.lastname: Heitmann
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D050154:Adiposity / Q000187:drug effects; D001628:Beverages / Q000009:adverse effects; D015992:Body Mass Index; D002648:Child; D003718:Denmark; D004032:Diet; D019422:Dietary Sucrose / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood / Q000209:etiology*; D055105:Waist Circumference; D015430:Weight Gain
chemical_list: D019422:Dietary Sucrose; D007328:Insulin