title: Profile of ocular and systemic characteristics in Möbius sequence patients from Brazil and Italy.
abstract: OBJECTIVE
  To compare the profiles and clinical findings of a series of patients with Möbius sequence from Brazil with a series from Italy.
  
  
  METHODS
  This is a multicenter study, which includes 46 Möbius sequence patients from Brazil and 20 from Italy. Socio-demographic, gestational, and neonatal profile characteristics were collected from interviews with the guardians of the Möbius sequence patients and compared. The Möbius sequence patients were submitted to an ophthalmologic examination and systemic malformations were also evaluated.
  
  
  RESULTS
  Misoprostol was used in the first trimester of pregnancy by 26 (56.5%) of the mothers of the Möbius sequence patients in the Brazilian series and was not used by any of the Italian mothers. The mean age of the Brazilian Möbius sequence patients was 89.95 ± 7.79 months and the mean age of the Italian patients was 102.6 ± 22.94 months (P=0.6105; Mann-Whitney test). Brazilian mothers had a significantly lower education level (P=0.0002; Fisher's exact test) and Italian mothers had significantly more stable relationships (p=0.0002; Fisher's exact test). The frequency of ocular and systemic abnormalities was similar in both series.
  
  
  CONCLUSIONS
  Adverse events during pregnancy varied between both groups. A history of misoprostol use during early pregnancy was present only in Brazilian mothers, who had lower levels of education and less frequent stable marital statuses. Clinical findings were similar between both groups of patients.
authors.affiliation: Department of Pediatric Ophthalmology and Strabismus, Fundação Altino Ventura, Recife, PE, Brazil. brunaventuramd@gmail.com
authors.forename: Bruna Vieira
authors.initials: BV
authors.lastname: Ventura
authors.forename: Marilyn Tiller
authors.initials: MT
authors.lastname: Miller
authors.forename: Diana
authors.initials: D
authors.lastname: Danda
authors.forename: Arturo
authors.initials: A
authors.lastname: Carta
authors.forename: Carlos Teixeira
authors.initials: CT
authors.lastname: Brandt
authors.forename: Liana Oliveira
authors.initials: LO
authors.lastname: Ventura
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D016595:Misoprostol / Q000009:adverse effects; D020331:Mobius Syndrome / Q000150:complications / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies; D012959:Socioeconomic Factors; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol