title: Association of mean platelet volume and pre- and postinterventional flow with infarct-related artery in ST-segment elevation myocardial infarction.
abstract: Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 840 patients with STEMI who underwent primary percutaneous coronary intervention (PCI). The patients were divided into 3 groups according to MPV tertiles. Pre- and post-PCI Thrombolysis In Myocardial Infarction (TIMI) flow grade was determined. Initial TIMI flow grade 3 was accepted as patent IRA. After the primary PCI, normal flow was defined as post-PCI TIMI flow 3. When the MPV was increased, the incidence of pre-PCI patent IRA (P = .004) and post-PCI normal TIMI flow (P < .001) was significantly decreased. Multivariate analysis showed that MPV was independently associated with post-PCI TIMI flow grade.
authors.affiliation: Department of Cardiology, Adana Numune Education and Research Hospital, Adana, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Durmuş Yildiray
authors.initials: DY
authors.lastname: Sahin
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloglu
authors.forename: Yahya Kemal
authors.initials: YK
authors.lastname: Icen
authors.forename: Caner
authors.initials: C
authors.lastname: Turkoglu
authors.forename: Bugra
authors.initials: B
authors.lastname: Ozkan
authors.forename: Onur Kadir
authors.initials: OK
authors.lastname: Uysal
authors.forename: Gulhan Yuksel
authors.initials: GY
authors.lastname: Kalkan
authors.forename: Murat
authors.initials: M
authors.lastname: Cayli
mesh_terms: D000368:Aged; D001792:Blood Platelets; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation; D004452:Echocardiography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D010976:Platelet Count; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012039:Regional Blood Flow; D016896:Treatment Outcome; D014654:Vascular Patency