title: Total synthesis of the proposed structure of cyclic hexadepsipeptide veraguamide A.
abstract: We have developed a practical method to assemble the proposed structure of natural product veraguamide A (1) by first preparing the three key fragments followed by optimization of the macrocyclization site. Although the synthetic product gave similar optical rotation to that reported for natural product, significant differences in the (1)H and (13)C NMR spectra were observed, especially the proton and carbon signals in the two N-MeVal moieties.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Dongyu
authors.initials: D
authors.lastname: Wang
authors.forename: Xian
authors.initials: X
authors.lastname: Jia
authors.forename: Ao
authors.initials: A
authors.lastname: Zhang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D047630:Depsipeptides; C559813:veraguamide A