title: Correlation between salivary interleukin-6 levels and early locoregional recurrence in patients with oral squamous cell carcinoma: preliminary study.
abstract: BACKGROUND
  We have demonstrated that salivary interleukin-6 (IL-6) concentrations change during the treatment in patients with oral squamous cell carcinoma (OSCC). We sought to elucidate the correlations between salivary IL-6 concentration and early locoregional recurrence in OSCC.
  
  
  METHODS
  Stimulated saliva was collected before and after surgery from 27 consecutive patients with OSCC. Recurrence-free survival (RFS) curves were plotted using the Kaplan-Meier method.
  
  
  RESULTS
  Of the 27 patients, 11 (41%) were diagnosed with locoregional recurrence within 24 months postsurgery. The median concentrations of IL-6 presurgery and postsurgery were 2.8 pg/mL and 2.1 pg/mL, respectively. The median postsurgery concentration of IL-6 was significantly higher in patients with than without locoregional recurrence (p = .02). Multivariate analysis revealed that postsurgery salivary IL-6 concentration was an independent risk factor for locoregional recurrence (p = .03; risk ratio, 0.14).
  
  
  CONCLUSIONS
  Posttreatment concentration of salivary IL-6 may predict early locoregional recurrence in OSCC.
authors.affiliation: Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, North 13, West 7, Kita-ku, Sapporo 060-8586, Japan. jun-s@den.hokudai.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohuchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Abe
authors.forename: Takehiko
authors.initials: T
authors.lastname: Satoh
authors.forename: Takahiro
authors.initials: T
authors.lastname: Abe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Satoh
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Notani
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000628:therapy; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000628:therapy; D015999:Multivariate Analysis; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism*
chemical_list: D015850:Interleukin-6