title: 25(OH)D3 in patients with ovarian cancer and its correlation with survival.
abstract: OBJECTIVE
  The aim of this study was to examine vitamin 25(OH)D3 concentration in ovarian cancer patients in relation to a pathological subtype of the tumor, FIGO stage, grading, menopause status and overall 5-year survival.
  
  
  METHODS
  72 epithelial ovarian cancer patients aged 37-79, who undergone optimal cytoreductive surgery were enrolled to the study group. Serum 25(OH)D3 concentration was measured using an electrochemiluminescence immunoassay before surgery. Serum concentration of 25(OH)D3 was also measured in a group of 65 healthy non-obese women aged 35-65 years.
  
  
  RESULTS
  In patients with ovarian cancer serum concentration of 25(OH)D3 was lower than in the reference group (12.5±7.75 ng/mL vs 22.4±6.5 ng/mL). No significant correlation was found between serum 25(OH)D3 concentration and histological subtype, grading, FIGO stage and menopausal status. The study group was divided into two subgroups and the survival curves were analyzed. Overall 5-year survival rate was significantly higher in the subgroup of patients with 25(OH)D3 concentration over 10 ng/mL compared to women with concentration below 10 ng/mL.
  
  
  CONCLUSIONS
  Low 25(OH) D3 concentration associated with lower overall survival rate might suggest for the important role of severe deficiency in more aggressive course of ovarian cancer. Testing for 25(OH)D in the standard procedure could help to find ovarian cancer patients with worse prognosis, who would benefit of special attention and supplementation.
authors.affiliation: Department of Obstetrics and Gynecology, L.Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University. walentowiczm@cm.umk.pl
authors.forename: M
authors.initials: M
authors.lastname: Walentowicz-Sadlecka
authors.forename: M
authors.initials: M
authors.lastname: Grabiec
authors.forename: P
authors.initials: P
authors.lastname: Sadlecki
authors.forename: M
authors.initials: M
authors.lastname: Gotowska
authors.forename: P
authors.initials: P
authors.lastname: Walentowicz
authors.forename: M
authors.initials: M
authors.lastname: Krintus
authors.forename: A
authors.initials: A
authors.lastname: Mankowska-Cyl
authors.forename: G
authors.initials: G
authors.lastname: Sypniewska
mesh_terms: D000328:Adult; D000368:Aged; D002112:Calcifediol / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality*
chemical_list: D002112:Calcifediol