title: Gender-specific reference intervals for cord blood leptin in Crete, Greece.
abstract: Cord leptin is a biomarker of fetal growth and adiposity with a role in predicting weight gain during the first months of life and childhood obesity. Our objective was to calculate gender-specific reference intervals for cord blood leptin in healthy neonates in Crete, Greece. We used data from the prospective mother-child cohort ("Rhea" study) in Crete, Greece. The analysis included 398 neonates chosen with strict inclusion criteria based on maternal and fetal characteristics. Cord leptin reference intervals for male neonates were 1.4-18.2 ng/mL and for females 2.0-25.8 ng/mL. Females had higher leptin levels (median 7.4; IQR 4.7-10.9) compared to males (median 4.9; IQR 3.2-7.6) (p < 0.001). Conclusion Gender-specific reference ranges are essential in clinical practice for correct interpretation of leptin values in cord blood and early detection of childhood obesity.
authors.affiliation: Department of Social Medicine, School of Medicine, University of Crete, PO Box 2208, 71003 Heraklion, Greece. p_karakosta@hotmail.com
authors.forename: Polyxeni
authors.initials: P
authors.lastname: Karakosta
authors.forename: Vaggelis
authors.initials: V
authors.lastname: Georgiou
authors.forename: Eleni
authors.initials: E
authors.lastname: Fthenou
authors.forename: Andrew
authors.initials: A
authors.lastname: Margioris
authors.forename: Elias
authors.initials: E
authors.lastname: Castanas
authors.forename: Manolis
authors.initials: M
authors.lastname: Kogevinas
authors.forename: Marilena
authors.initials: M
authors.lastname: Kampa
authors.forename: Leda
authors.initials: L
authors.lastname: Chatzi
mesh_terms: D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006115:Greece; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D020738:Leptin